PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2561421-8	1989	A type II beta-turn involving residues Thr6, Leu7, and Pro8 is well represented in the computed conformers as is a hydrogen bonding interaction between the NH of Leu3 and the carbonyl oxygen of Thr6.	Hydrogen	115-123	beta-1,3-glucuronyltransferase 1	Homo sapiens	45-49
2692717-1	1989	The aromatic 1H NMR resonances of the insulin monomer are assigned at 500 MHz by comparative studies of chemically modified and genetically altered variants, including a mutant insulin (PheB25----Leu) associated with diabetes mellitus.	Hydrogen	13-15	insulin	Homo sapiens	38-45
2692717-1	1989	The aromatic 1H NMR resonances of the insulin monomer are assigned at 500 MHz by comparative studies of chemically modified and genetically altered variants, including a mutant insulin (PheB25----Leu) associated with diabetes mellitus.	Hydrogen	13-15	insulin	Homo sapiens	177-184
2597191-2	1989	A large, 5.8-fold deuterium isotope effect for the formation clearance of the monomethylester (M-1) was observed, which is strongly indicative for an oxidative reaction mechanism involving the abstraction of a hydrogen atom, presumably by cytochrome P-450.	Hydrogen	210-218	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	239-255
2489100-4	1989	Temperature dependence of NH proton chemical shift and NOE experiments showed that Boc-Asn-Aib-Thr-Aib-OMe has a tendency to form a beta-turn structure with a hydrogen bond involving Thr and Aib4 NH groups.	Hydrogen	159-167	amyloid beta precursor protein	Homo sapiens	130-136
2481315-1	1989	The potential binding of angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) (AII) to a peptide encoded by its complementary RNA (Lys-Gly-Val-Asp-Val-Tyr-Ala-Val) (IIA) has been studied by monitoring the 1H NMR spectrum of IIA in aqueous phosphate or Tris.HCl buffer (2H2O) as it is titrated with AII.	Hydrogen	201-203	angiotensinogen	Homo sapiens	25-39
2481315-1	1989	The potential binding of angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) (AII) to a peptide encoded by its complementary RNA (Lys-Gly-Val-Asp-Val-Tyr-Ala-Val) (IIA) has been studied by monitoring the 1H NMR spectrum of IIA in aqueous phosphate or Tris.HCl buffer (2H2O) as it is titrated with AII.	Hydrogen	201-203	NLR family pyrin domain containing 3	Homo sapiens	75-78
2605208-0	1989	Hydrogen exchange of the tryptophan residues in bovine, goat, guinea pig, and human alpha-lactalbumin.	Hydrogen	0-8	lactalbumin alpha	Homo sapiens	84-101
2613442-5	1989	The crystal conformation differs from all the other conformations proposed for FMLP-OMe and the anionic form of N-formyl-L-Met-L-Leu-L-Phe-OH (FMLP) in solution accounts for the amphiphilic character of the peptide, giving rise, through intermolecular hydrogen bonds, to a stacking of molecules which could be maintained in the aggregation states experimentally observed in solvents of low polarity.	Hydrogen	252-260	formyl peptide receptor 1	Homo sapiens	79-83
2613442-5	1989	The crystal conformation differs from all the other conformations proposed for FMLP-OMe and the anionic form of N-formyl-L-Met-L-Leu-L-Phe-OH (FMLP) in solution accounts for the amphiphilic character of the peptide, giving rise, through intermolecular hydrogen bonds, to a stacking of molecules which could be maintained in the aggregation states experimentally observed in solvents of low polarity.	Hydrogen	252-260	formyl peptide receptor 1	Homo sapiens	143-147
2587934-4	1989	When PBL were stimulated with PHA, IL-2, or Con A a reduced reactivity of H2 could be seen.	Hydrogen	74-76	interleukin 2	Homo sapiens	35-39
2558718-0	1989	1H NMR structural characterization of a recombinant kringle 2 domain from human tissue-type plasminogen activator.	Hydrogen	0-2	plasminogen activator, tissue type	Homo sapiens	80-113
2558718-1	1989	The kringle 2 domain of human tissue-type plasminogen activator (t-PA) has been characterized via 1H NMR spectroscopy at 300 and 620 MHz.	Hydrogen	98-100	plasminogen activator, tissue type	Homo sapiens	30-63
2558718-1	1989	The kringle 2 domain of human tissue-type plasminogen activator (t-PA) has been characterized via 1H NMR spectroscopy at 300 and 620 MHz.	Hydrogen	98-100	plasminogen activator, tissue type	Homo sapiens	65-69
2681204-2	1989	The 1H-NMR spectrum of IL-8 is assigned in a sequential manner and regular elements of secondary structure are identified on the basis of a qualitative interpretation of the nuclear Overhauser, coupling constant and amide exchange data.	Hydrogen	4-6	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
2681204-4	1989	It is shown that IL-8 is a dimer in solution in which the interface is principally formed by six backbone hydrogen bonds between residues 25, 27, and 29 of one monomer and residues 29, 27, and 25, respectively, of the other.	Hydrogen	106-114	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
2605208-1	1989	Hydrogen exchange of the individual tryptophan residues of bovine, goat, guinea pig, and human alpha-lactalbumin has been studied by both ultraviolet and NMR spectra.	Hydrogen	0-8	lactalbumin alpha	Homo sapiens	95-112
2605208-3	1989	Taking account of the thermal unfolding of each alpha-lactalbumin, the hydrogen exchange rates of the individual tryptophan residues are analyzed.	Hydrogen	71-79	lactalbumin alpha	Homo sapiens	48-65
2792084-6	1989	A network of seven hydrogen bonds connects oxygen atoms O-3, O-4, O-5 and O-6 of the mannoside to residues Asn14, Leu99, Tyr100, Asp208 and Arg228.	Hydrogen	19-27	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	56-59
2557291-1	1989	investigation of the hydrogen exchange in H2O of the peptide fragment B23-B29 of insulin.	Hydrogen	21-29	insulin	Homo sapiens	81-88
2557291-2	1989	Detailed and precise information on the exchanges in water of the peptide hydrogens of the insulin fragment B23-B29 (Gly23-Phe24-Phe25-Tyr26-Thr27-Pro28 -Lys29) has been obtained from magnetization-transfer measurements, and nonlinear least-squares fits of the experimental spectra using the expression for the discrete Fourier transform of a sum of exponentially damped sinusoids.	Hydrogen	74-83	insulin	Homo sapiens	91-98
2549267-12	1989	In contrast, aldosterone secretion following H2 correlated with both the AII-PR (r = 0.54; p less than 0.01) and ACTH-PR (r = 0.71; p less than 0.001) and multiple regression analysis showed a highly significant relation with both AII and ACTH (r = 0.81; p less than 0.001).	Hydrogen	45-47	proopiomelanocortin	Homo sapiens	113-120
2549267-12	1989	In contrast, aldosterone secretion following H2 correlated with both the AII-PR (r = 0.54; p less than 0.01) and ACTH-PR (r = 0.71; p less than 0.001) and multiple regression analysis showed a highly significant relation with both AII and ACTH (r = 0.81; p less than 0.001).	Hydrogen	45-47	proopiomelanocortin	Homo sapiens	113-117
2549267-13	1989	The data suggest that aldosterone secretion after initial small hemorrhage occurs as a result of increased AII, whereas both AII and ACTH may contribute to the larger aldosterone secretory response to H2.	Hydrogen	201-203	proopiomelanocortin	Homo sapiens	133-137
2776756-1	1989	Assignments for 1H-NMR resonances of most of the residues of bovine pancreatic ribonuclease (RNase A) have been obtained by sequence-specific methods.	Hydrogen	16-18	ribonuclease pancreatic	Bos taurus	93-100
2590249-0	1989	[A study of the interaction of substrates with cytochrome P-450 by a method of UV- and 1H-NMR spectroscopy].	Hydrogen	87-89	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	47-63
2489081-4	1989	The residues Arg 151 and Asn 232 of ABP from bidentate hydrogen bonds with both L-arabinose and D-galactose, but not with D-fucose or D-glucose.	Hydrogen	55-63	sex hormone binding globulin	Homo sapiens	36-39
2620666-6	1989	Both hydrogen- and hydrophobic bonds are involved in the interaction between PRL and the receptor.	Hydrogen	5-13	prolactin	Oryctolagus cuniculus	77-80
2554966-1	1989	1H nuclear magnetic resonance (1H NMR) experiments on Co(II)-substituted stellacyanin have been performed.	Hydrogen	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
2554966-1	1989	1H nuclear magnetic resonance (1H NMR) experiments on Co(II)-substituted stellacyanin have been performed.	Hydrogen	31-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
2592252-5	1989	PGDH activity in periportal areas showed a Vmax of 10.84 +/- 0.33 mumol H2 cm3 min-1.	Hydrogen	72-74	phosphogluconate dehydrogenase	Rattus norvegicus	0-4
2692597-1	1989	Resonance assignments of the 1H spectrum of insulin are the basis on which to investigate its solution conformation by using NMR method.	Hydrogen	29-31	insulin	Homo sapiens	44-51
2692597-3	1989	S-sulfonated A and B chains of insulin gave 1H spectra with good resolutions.	Hydrogen	44-46	insulin	Homo sapiens	31-38
2546604-1	1989	The interaction of aromatic donor molecules with lactoperoxidase (LPO) was studied using 1H-NMR and optical difference spectroscopy techniques.	Hydrogen	89-91	lactoperoxidase	Homo sapiens	49-64
2775751-9	1989	The active site histidine, His-186, is hydrogen bonded from nitrogen ND1 to the carboxylate of Asp-158 and from its nitrogen NE2 to the sulfate ion bound in the putative substrate binding site.	Hydrogen	39-47	NADH dehydrogenase subunit 1	Sus scrofa	69-72
2546604-1	1989	The interaction of aromatic donor molecules with lactoperoxidase (LPO) was studied using 1H-NMR and optical difference spectroscopy techniques.	Hydrogen	89-91	lactoperoxidase	Homo sapiens	66-69
2737312-3	1989	There was a direct linear relationship between pH and the concentration of CEA measured by the assay, such that as hydrogen ion concentration increased, the apparent concentration fell.	Hydrogen	115-123	CEA cell adhesion molecule 3	Homo sapiens	75-78
2546452-4	1989	ACTH did not change after H1 but increased after H2, and the H2 response was larger (P less than 0.01).	Hydrogen	49-51	proopiomelanocortin	Canis lupus familiaris	0-4
2546452-11	1989	On the other hand, the markedly potentiated vasopressin response to H2, which parallels that of ACTH, suggests that vasopressin may mediate the increased ACTH responses to H2.	Hydrogen	68-70	proopiomelanocortin	Canis lupus familiaris	154-158
2546452-11	1989	On the other hand, the markedly potentiated vasopressin response to H2, which parallels that of ACTH, suggests that vasopressin may mediate the increased ACTH responses to H2.	Hydrogen	172-174	proopiomelanocortin	Canis lupus familiaris	96-100
2546452-11	1989	On the other hand, the markedly potentiated vasopressin response to H2, which parallels that of ACTH, suggests that vasopressin may mediate the increased ACTH responses to H2.	Hydrogen	172-174	proopiomelanocortin	Canis lupus familiaris	154-158
2730944-0	1989	Two-dimensional 1H-NMR study of the 1-34 fragment of human parathyroid hormone.	Hydrogen	16-18	parathyroid hormone	Homo sapiens	59-78
2529383-6	1989	In the blood flow measurement after the intravenous infusion of each pentagastrin, isoproterenol, and vasopressin, flow signal of the LDV method could detect the each effect of these drugs on gastric mucosal blood flow as well as well as the hydrogen gas clearance technique.	Hydrogen	242-250	arginine vasopressin	Rattus norvegicus	102-113
2548589-0	1989	Binding of thiocyanate to lactoperoxidase: 1H and 15N nuclear magnetic resonance studies.	Hydrogen	43-45	lactoperoxidase	Homo sapiens	26-41
2548589-1	1989	The binding of thiocyanate to lactoperoxidase (LPO) has been investigated by 1H and 15N NMR spectroscopy.	Hydrogen	77-79	lactoperoxidase	Homo sapiens	30-45
2548589-1	1989	The binding of thiocyanate to lactoperoxidase (LPO) has been investigated by 1H and 15N NMR spectroscopy.	Hydrogen	77-79	lactoperoxidase	Homo sapiens	47-50
2548589-2	1989	1H NMR of LPO shows that the major broad heme methyl proton resonance at about 61 ppm is shifted upfield by addition of the thiocyanate, indicating binding of the thiocyanate to the enzyme.	Hydrogen	0-2	lactoperoxidase	Homo sapiens	10-13
2753867-3	1989	Structure determination of the two components, named GL-I3 and GL-II3, which were finally purified from GL-I and GL-II, respectively, by HPLC on a reversed phase column, was performed by means of 1H-NMR spectroscopy, fast atom bombardment mass spectrometry, and component analysis involving GLC-mass spectrometry.	Hydrogen	196-198	GLI family zinc finger 3	Homo sapiens	53-58
16666878-2	1989	The sequence of events leading to the photoevolution of H(2) from acetate includes the conversion of acetate into succinate via the extraplastidic glyoxylate cycle, the oxidation of succinate to fumarate by chloroplastic succinate dehydrogenase, and the oxidation of malate to oxaloacetate in the chloroplast by NAD dependent malate dehydrogenase.	Hydrogen	56-60	uncharacterized protein	Chlamydomonas reinhardtii	326-346
2673508-0	1989	Computer-assisted structural analysis of polysaccharides with an extended version of CASPER using 1H- and 13C-n.m.r.	Hydrogen	98-100	CASP8 and FADD like apoptosis regulator	Homo sapiens	85-91
2499045-1	1989	The hydrogen-bonding status of His57 in the catalytic triad (Asp-His-Ser) of serine protease has important mechanistic implications for this class of enzymes.	Hydrogen	4-12	coagulation factor II, thrombin	Homo sapiens	77-92
2752005-1	1989	Calcium-containing calmodulin (CaM) and its complex with a peptide corresponding to the calmodulin-binding domain of skeletal muscle myosin light chain kinase [skMLCK(576-594)G] have been studied by one- and two-dimensional 1H NMR techniques.	Hydrogen	224-226	calmodulin 1	Homo sapiens	31-34
2928325-0	1989	Proline isomerism leads to multiple folded conformations of calbindin D9k: direct evidence from two-dimensional 1H NMR spectroscopy.	Hydrogen	112-114	S100 calcium binding protein G	Homo sapiens	60-73
2568738-1	1989	It has been questioned whether the interaction of H2-antagonists with cytochrome P-450 that is observed in vitro is also relevant for the in vivo situation.	Hydrogen	50-52	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	70-86
2736040-2	1989	In order to study the Ca2+-dependent binding properties of S100b, its interaction with a calmodulin antagonist, trifluoperazine (TFP), was investigated using [19F]- and [1H]-NMR and UV-difference spectroscopy.	Hydrogen	170-172	S100 calcium binding protein B	Homo sapiens	59-64
2928325-1	1989	A complete analysis of calbindin D9k by two-dimensional 1H nuclear magnetic resonance spectroscopy has established the existence of two conformations for the folded protein in solution.	Hydrogen	56-58	S100 calcium binding protein G	Homo sapiens	23-36
2646637-0	1989	Sequence-specific 1H-NMR assignments and identification of two small antiparallel beta-sheets in the solution structure of recombinant human transforming growth factor alpha.	Hydrogen	18-20	tumor necrosis factor	Homo sapiens	141-173
2646119-0	1989	A high-resolution 1H-NMR study of human transforming growth factor alpha.	Hydrogen	18-20	tumor necrosis factor	Homo sapiens	40-72
2646119-2	1989	The 500-MHz and 600-MHz 1H-NMR spectra of recombinant human transforming growth factor alpha have been recorded at pH values of 3.8, 6.5 and 9.4.	Hydrogen	24-26	tumor necrosis factor	Homo sapiens	60-92
2785403-0	1989	Polypeptide chain fold of human transforming growth factor alpha analogous to those of mouse and human epidermal growth factors as studied by two-dimensional 1H NMR.	Hydrogen	158-160	tumor necrosis factor	Homo sapiens	32-64
2785403-1	1989	The 1H NMR spectrum of human transforming growth factor alpha (TGF-alpha) was analyzed almost completely by the sequential assignment method using two-dimensional NMR techniques.	Hydrogen	4-6	tumor necrosis factor	Homo sapiens	29-61
2730871-1	1989	The utility of three-dimensional heteronuclear NMR spectroscopy for the assignment of 1H and 15N resonances of the inflammatory protein C5a (MW 8500), uniformly labeled with 15N, is demonstrated at a protein concentration of 0.7 mM.	Hydrogen	86-88	complement C5a receptor 1	Homo sapiens	136-139
2730873-4	1989	Complete 1H NMR assignments were made for VIP" in 25% methanol at pH 4 and 6 and in 50% methanol at pH 6, using two-dimensional COSY, NOESY, and relay-COSY experiments.	Hydrogen	9-11	vasoactive intestinal peptide	Homo sapiens	42-45
2710783-8	1989	Our data suggest that in porcine pancreatic phospholipase A2 the hydroxyl group of Tyr-69 serves to fix and orient the phosphate group of phospholipid monomers by hydrogen bonding.	Hydrogen	163-171	phospholipase A2 group IB	Homo sapiens	44-60
2642711-0	1989	High resolution 1H-NMR studies of Des-(B26-B30)-insulin; assignment of resonances and properties of aromatic residues.	Hydrogen	16-18	insulin	Homo sapiens	48-55
2642711-1	1989	The assignments of 1H resonances of the eight aromatic residues of Des-(B26-B30)-insulin are reported, based on pH titration, selective spin decoupling and its 500 MHz 1H two-dimensional (2D)-COSY spectrum.	Hydrogen	19-21	insulin	Homo sapiens	81-88
2642711-1	1989	The assignments of 1H resonances of the eight aromatic residues of Des-(B26-B30)-insulin are reported, based on pH titration, selective spin decoupling and its 500 MHz 1H two-dimensional (2D)-COSY spectrum.	Hydrogen	168-170	insulin	Homo sapiens	81-88
2642711-5	1989	From this study of the low-field region of 1H-NMR spectrum of Des-(B26-B30)-insulin, we conclude that this molecule probably maintains the major structural features of insulin in aqueous solution, but there are some readjustments of the peptide conformation.	Hydrogen	43-45	insulin	Homo sapiens	76-83
2624704-2	1989	The rate of hydrolysis was subject to specific acid catalysis, the specific hydrogen ion catalytic rate constant being 3.6 X 10(-3) M-1 min-1 at 37 degrees C and mu = 0.5.	Hydrogen	76-84	CD59 molecule (CD59 blood group)	Homo sapiens	136-141
2523589-0	1989	Interleukin-2 and immunoglobulin increases with H2-antagonists in humans.	Hydrogen	48-50	interleukin 2	Homo sapiens	0-13
2535849-9	1989	We attribute the acid/alkaline transition in the ferrous forms of cytochrome c peroxidase to a rearrangement mainly of the proximal side of the heme, culminating in a change of steric interactions between the proximal histidine and the heme or of the hydrogen bonding network involving the proximal histidine.	Hydrogen	251-259	cytochrome c, somatic	Homo sapiens	66-78
2713333-0	1989	1H NMR assignment and secondary structural elements of human transforming growth factor alpha.	Hydrogen	0-2	tumor necrosis factor	Homo sapiens	61-93
2713333-1	1989	The 1H NMR spectrum of human transforming growth factor alpha (hTGF-alpha) has been completely assigned, and secondary structural elements have been identified as a preliminary step in determining the structure of this protein by distance geometry methods.	Hydrogen	4-6	tumor necrosis factor	Homo sapiens	29-61
3149201-0	1988	Secondary structure of the human growth hormone releasing factor (GRF 1-29) by two-dimensional 1H-nmr spectroscopy.	Hydrogen	95-97	growth hormone releasing hormone	Homo sapiens	33-64
2470438-0	1989	1H-NMR studies of receptor-selective substance P analogues reveal distinct predominant conformations in DMSO-d6.	Hydrogen	0-2	tachykinin precursor 1	Homo sapiens	37-48
3198602-10	1988	Camphane bound to cytochrome P-450cam exhibits a larger decrease in high spin fraction (45%) and a correspondingly larger KD (46 microM), suggesting that the carbonyl moiety of camphor plays an important steric role in addition to its interaction as a hydrogen bond acceptor.	Hydrogen	252-260	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	18-34
2720122-0	1989	Conformational behavior of cyclic CCK-related peptides determined by 400-MHz 1H-NMR: relationships with affinity and selectivity for brain receptors.	Hydrogen	77-79	cholecystokinin	Homo sapiens	34-37
3203684-6	1988	1H-NMR spectra of the peptide in aqueous solution show that the two amide hydrogens of Asp4 and Ser5 exchange very slowly.	Hydrogen	0-2	napsin A aspartic peptidase	Homo sapiens	87-91
3203684-6	1988	1H-NMR spectra of the peptide in aqueous solution show that the two amide hydrogens of Asp4 and Ser5 exchange very slowly.	Hydrogen	74-83	napsin A aspartic peptidase	Homo sapiens	87-91
3149997-5	1988	The direct involvement of water in the retinal binding site was demonstrated by measuring the rhodopsin-bathorhodopsin FTIR difference spectra of rhodopsin hydrated with H2O and H2(18)O.	Hydrogen	170-172	rhodopsin	Homo sapiens	94-103
3149997-5	1988	The direct involvement of water in the retinal binding site was demonstrated by measuring the rhodopsin-bathorhodopsin FTIR difference spectra of rhodopsin hydrated with H2O and H2(18)O.	Hydrogen	170-172	rhodopsin	Homo sapiens	109-118
3205158-4	1988	Experimental studies of a two-compartment phantom show that this method (SLIM) can be used to derive regional hydrogen spectra of a single slice from signals with as few as 2 phase-encoding steps, although Fourier transform chemical-shift imaging requires 64 steps to achieve a result of comparable accuracy.	Hydrogen	110-118	kelch domain containing 10	Homo sapiens	73-77
3210442-0	1988	1H-NMR studies of calmodulin: the modifying effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) on the calcium-induced conformational changes of calmodulin.	Hydrogen	0-2	calmodulin 1	Homo sapiens	18-28
3210442-1	1988	The effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide), a calmodulin antagonist, on the calcium-bound conformation of calmodulin was studied by 1H-NMR at 400 MHz.	Hydrogen	160-162	calmodulin 1	Homo sapiens	134-144
2846041-1	1988	The catalysis of the hydrolysis of angiotensin I, an important natural substrate, by human angiotensin-converting enzyme (ACE) was examined in detail as a function of chloride and hydrogen ion concentration.	Hydrogen	180-188	angiotensinogen	Homo sapiens	35-48
2459709-1	1988	Simulation of the molecular dynamics of a small protein, bovine pancreatic trypsin inhibitor, was found to be more realistic when water molecules were included than when in vacuo: the time-averaged structure was much more like that observed in high-resolution x-ray studies, the amplitudes of atomic vibration in solution were smaller, and fewer incorrect hydrogen bonds were formed.	Hydrogen	356-364	trophoblast Kunitz domain protein 1	Bos taurus	75-92
3138238-6	1988	The mechanism of the desaturation reaction was studied by inter- and intramolecular deuterium isotope effect experiments, which demonstrated that removal of a hydrogen atom from the subterminal C-4 position of VPA is rate limiting in the formation of both 4-ene- and 4-hydroxy-VPA.	Hydrogen	159-167	complement C4A	Rattus norvegicus	194-197
2841357-0	1988	Angiotensin II stimulation of hydrogen ion secretion in the rat early proximal tubule.	Hydrogen	30-38	angiotensinogen	Rattus norvegicus	0-14
2841357-3	1988	We recently found that hydrogen ion secretion, which effects sodium bicarbonate absorption, was a transport function preferentially and potently increased by angiotensin II in S1 cells.	Hydrogen	23-31	angiotensinogen	Rattus norvegicus	158-172
2841357-6	1988	Direct control of hydrogen ion secretion by angiotensin II via receptors on epithelial cells has not been previously demonstrated.	Hydrogen	18-26	angiotensinogen	Rattus norvegicus	44-58
2841357-7	1988	We now report that stimulation of in vivo hydrogen ion secretion in the rat early proximal tubule by angiotensin II was not mediated via change in nerve activity.	Hydrogen	42-50	angiotensinogen	Rattus norvegicus	101-115
2841357-8	1988	Rather, enhanced hydrogen ion secretion by angiotensin II correlated with increased angiotensin II receptor density on epithelial cells in the early compared to late microdissected proximal tubule.	Hydrogen	17-25	angiotensinogen	Rattus norvegicus	43-57
2841357-8	1988	Rather, enhanced hydrogen ion secretion by angiotensin II correlated with increased angiotensin II receptor density on epithelial cells in the early compared to late microdissected proximal tubule.	Hydrogen	17-25	angiotensinogen	Rattus norvegicus	84-98
2841357-10	1988	Angiotensin II reduced bicarbonate permeability and caused alteration in the apparent substrate affinity, but not maximal capacity, of the proximal hydrogen ion secretory system involving the Na+/H+ antiporter.	Hydrogen	148-156	angiotensinogen	Rattus norvegicus	0-14
2846041-1	1988	The catalysis of the hydrolysis of angiotensin I, an important natural substrate, by human angiotensin-converting enzyme (ACE) was examined in detail as a function of chloride and hydrogen ion concentration.	Hydrogen	180-188	angiotensin I converting enzyme	Homo sapiens	91-120
2846041-1	1988	The catalysis of the hydrolysis of angiotensin I, an important natural substrate, by human angiotensin-converting enzyme (ACE) was examined in detail as a function of chloride and hydrogen ion concentration.	Hydrogen	180-188	angiotensin I converting enzyme	Homo sapiens	122-125
3387219-6	1988	The 1H chemical shifts for the trans-syn thymine dimer unit of the decamer were found to be quite similar to those found for the trans-syn thymine dimer of TpT.	Hydrogen	4-6	limb development membrane protein 1	Homo sapiens	156-159
3372517-1	1988	A variety of different 4-substituted 1,4-dihydropyridine Hantzsch esters are substrates for ring dehydrogenation by a cytochrome P-450 (P-450) enzyme (P-450 UT-A); the substitutent could be varied from a hydrogen to a naphthalenyl, but a pyrenyl derivative was not dehydrogenated.	Hydrogen	99-107	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	118-134
2843652-1	1988	Solution structures of the rabbit neutrophil defensin NP-5 have been determined by 1H nuclear magnetic resonance (n.m.r.)	Hydrogen	83-85	neutrophil antibiotic peptide NP-5	Oryctolagus cuniculus	45-58
3408713-0	1988	Sequence-specific assignments in the 1H NMR spectrum of the human inflammatory protein C5a.	Hydrogen	37-39	complement C5a receptor 1	Homo sapiens	87-90
3408713-1	1988	Full sequence-specific assignments for the 1H NMR lines of the backbone protons of the human complement factor C5a are described and documented.	Hydrogen	43-45	complement C5a receptor 1	Homo sapiens	111-114
3382718-0	1988	1H-nmr studies of the 20-31 fragment of calmodulin and of its cyclic analogue.	Hydrogen	0-2	calmodulin 1	Homo sapiens	40-50
3360006-2	1988	New neutral oligosaccharides from cow colostrum kappa-casein were identified and characterized by 500-MHz 1H-NMR spectroscopy.	Hydrogen	106-108	casein kappa	Bos taurus	48-60
2840956-4	1988	The analogue, mPD derivative, has the requisite charged end groups and a number of potential hydrogen-bonding loci equal to those of distamycin.	Hydrogen	93-101	mevalonate (diphospho) decarboxylase	Mus musculus	14-17
16347526-4	1988	Floc preparations accumulated fourfold-higher levels of formate (40 muM) than digestor contents, and the free flora was the primary site for formate cleavage to CO(2) and H(2) (90 muM formate per h).	Hydrogen	171-175	latexin	Homo sapiens	180-183
3338452-8	1988	From 1H-NMR investigations, conformational changes within the protein, due to a sort of disaggregation of hFABP upon fatty acid binding, were derived.	Hydrogen	5-7	fatty acid binding protein 3	Homo sapiens	106-111
3221192-5	1988	The effect of NO3- on methanogenesis was twofold: firstly, H2 accumulation decreased due to diversion of electrons towards NO3-/NO2- reduction, and as a result of H2 being used as an electron donor for NO3- reduction, resulting in the removal of the methanogenic substrate; secondly, there was direct inhibition of methane-producing bacteria by NO3- and NO2-.	Hydrogen	59-61	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
3221192-5	1988	The effect of NO3- on methanogenesis was twofold: firstly, H2 accumulation decreased due to diversion of electrons towards NO3-/NO2- reduction, and as a result of H2 being used as an electron donor for NO3- reduction, resulting in the removal of the methanogenic substrate; secondly, there was direct inhibition of methane-producing bacteria by NO3- and NO2-.	Hydrogen	59-61	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
3221192-5	1988	The effect of NO3- on methanogenesis was twofold: firstly, H2 accumulation decreased due to diversion of electrons towards NO3-/NO2- reduction, and as a result of H2 being used as an electron donor for NO3- reduction, resulting in the removal of the methanogenic substrate; secondly, there was direct inhibition of methane-producing bacteria by NO3- and NO2-.	Hydrogen	59-61	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
3221192-5	1988	The effect of NO3- on methanogenesis was twofold: firstly, H2 accumulation decreased due to diversion of electrons towards NO3-/NO2- reduction, and as a result of H2 being used as an electron donor for NO3- reduction, resulting in the removal of the methanogenic substrate; secondly, there was direct inhibition of methane-producing bacteria by NO3- and NO2-.	Hydrogen	59-61	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
3221192-5	1988	The effect of NO3- on methanogenesis was twofold: firstly, H2 accumulation decreased due to diversion of electrons towards NO3-/NO2- reduction, and as a result of H2 being used as an electron donor for NO3- reduction, resulting in the removal of the methanogenic substrate; secondly, there was direct inhibition of methane-producing bacteria by NO3- and NO2-.	Hydrogen	163-165	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
2831960-4	1988	In the 1H NMR spectrum of the 1:1 complex, the selective chemical shifts and removal of degeneracy of AH2(4), AH2(5), T-CH3(6), and T-CH3(7) due to the anisotropy effects of the heterocyclic moieties of the ligand, and with lesser effects at the flanking base sites C(3) and G(8), locate the drug centrally in the decadeoxyribonucleotide.	Hydrogen	7-9	zinc finger RANBP2-type containing 3	Homo sapiens	102-105
2831960-4	1988	In the 1H NMR spectrum of the 1:1 complex, the selective chemical shifts and removal of degeneracy of AH2(4), AH2(5), T-CH3(6), and T-CH3(7) due to the anisotropy effects of the heterocyclic moieties of the ligand, and with lesser effects at the flanking base sites C(3) and G(8), locate the drug centrally in the decadeoxyribonucleotide.	Hydrogen	7-9	zinc finger RANBP2-type containing 3	Homo sapiens	110-113
3268034-0	1988	[1H, 3H-quinazolinediones-2,4: synthesis, physicochemical characteristics and study of the denaturation inhibition of bovine serum albumin].	Hydrogen	1-3	albumin	Homo sapiens	125-139
3043709-0	1988	[Insulin as a regulator of hydrogen ion homeostasis].	Hydrogen	27-35	insulin	Homo sapiens	1-8
3346193-1	1988	Detailed studies on the 13C and 1H NMR spectra of chromomycins A2 and A3, olivomycins A and B, and their derivatives clarified the assignment of many signals which had been unassigned or erroneously reported in the literatures.	Hydrogen	32-34	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	70-93
3427016-2	1987	The most significant effects of binding were large downfield shifts in the amino nitrogen resonance of Phe-3 of vasopressin and in its associated proton, providing evidence that the peptide bond between residues 2 and 3 of the hormones is hydrogen-bonded to the protein within hormone-neurophysin complexes.	Hydrogen	239-247	arginine vasopressin	Homo sapiens	112-123
3677088-7	1987	1H-NMR analyses of Friend leukemia cell tumor extracts also indicated, 6 h after tumor injection with TNF: (a) elevated choline levels (9X); (b) a 19-fold increase in the ratio [choline]/[phosporylcholine]; (c) elevated (1.4X) levels of lactic acid; and (d) a 1.6-fold decrease in the [taurine]/[glycine] ratio.	Hydrogen	0-2	tumor necrosis factor	Mus musculus	102-105
2960378-0	1987	Secondary structure determination of human beta-endorphin by 1H NMR spectroscopy.	Hydrogen	61-63	proopiomelanocortin	Homo sapiens	43-57
17800460-3	1987	22H(2)O, the maltohexaose units form an antiparallel, left-handed double helix with O-2 ... O-3 and O-6 ... O-6 hydrogen bonding and a central cavity that encloses two triiodide units.	Hydrogen	112-120	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	92-103
2960378-1	1987	The 1H NMR spectra of human beta-endorphin indicate that the peptide exists in random-coil form in aqueous solution but becomes helical in mixed solvent.	Hydrogen	4-6	proopiomelanocortin	Homo sapiens	28-42
3611098-5	1987	The result of Ca2+ binding was compared with 1H NMR spectra of calmodulin in the presence of equimolar concentration of mastoparan.	Hydrogen	45-47	calmodulin 1	Homo sapiens	63-73
3622513-9	1987	Both His and Arg can make a hydrogen bond to a phosphate oxygen atom of NAD; hence the lower turnover rate of beta 1 apparently derives from a charge effect.	Hydrogen	28-36	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	110-116
3622513-12	1987	The important difference between gamma 1 and gamma 2 is an exchange at position 271 from Arg to Gln which can give a hydrogen bond from Gln in gamma 2 to the adenine of NAD.	Hydrogen	117-125	tryptophanyl-tRNA synthetase 1	Homo sapiens	45-52
3622513-12	1987	The important difference between gamma 1 and gamma 2 is an exchange at position 271 from Arg to Gln which can give a hydrogen bond from Gln in gamma 2 to the adenine of NAD.	Hydrogen	117-125	tryptophanyl-tRNA synthetase 1	Homo sapiens	143-150
2444253-0	1987	Solvent exchange of buried water and hydrogen exchange of peptide NH groups hydrogen bonded to buried waters in bovine pancreatic trypsin inhibitor.	Hydrogen	37-45	trophoblast Kunitz domain protein 1	Bos taurus	130-147
3271463-2	1987	Both are in the free base form and have an intramolecular-hydrogen bond between N10 of the acridine and the nitrogen atom of the carboxamide substituent.	Hydrogen	58-66	nuclear receptor subfamily 4 group A member 1	Homo sapiens	80-83
2444253-0	1987	Solvent exchange of buried water and hydrogen exchange of peptide NH groups hydrogen bonded to buried waters in bovine pancreatic trypsin inhibitor.	Hydrogen	76-84	trophoblast Kunitz domain protein 1	Bos taurus	130-147
2956998-0	1987	Two-dimensional 1H-NMR investigation of the water conformation of the atrial natriuretic factor (ANF 101-126).	Hydrogen	16-18	natriuretic peptide A	Homo sapiens	97-100
3663604-7	1987	These findings suggest the existence of the following physiologically important natures of the cytochrome P-450scc active site: (1) there is a strong steric interaction between heme-bound carbon monoxide and the 22(R)-hydroxyl group or the 22(R)-hydrogen of the steroid side chain and (2) the hydroxylation at the 20S position may cause a conformational change of the side-chain group relative to the heme.	Hydrogen	246-254	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	95-114
2440473-0	1987	Hydrogen exchange kinetics of bovine pancreatic trypsin inhibitor beta-sheet protons in trypsin-bovine pancreatic trypsin inhibitor, trypsinogen-bovine pancreatic trypsin inhibitor, and trypsinogen-isoleucylvaline-bovine pancreatic trypsin inhibitor.	Hydrogen	0-8	trophoblast Kunitz domain protein 1	Bos taurus	48-65
3312053-0	1987	Conformational analysis of pepstatin and related renin inhibitors by 400 MHz 1H n.m.r.	Hydrogen	77-79	renin	Homo sapiens	49-54
3038176-0	1987	Proton nuclear magnetic resonance spectroscopy of human transferrin N-terminal half-molecule: titration and hydrogen-deuterium exchange.	Hydrogen	108-116	transferrin	Homo sapiens	56-67
2440473-0	1987	Hydrogen exchange kinetics of bovine pancreatic trypsin inhibitor beta-sheet protons in trypsin-bovine pancreatic trypsin inhibitor, trypsinogen-bovine pancreatic trypsin inhibitor, and trypsinogen-isoleucylvaline-bovine pancreatic trypsin inhibitor.	Hydrogen	0-8	trophoblast Kunitz domain protein 1	Bos taurus	114-131
2440473-0	1987	Hydrogen exchange kinetics of bovine pancreatic trypsin inhibitor beta-sheet protons in trypsin-bovine pancreatic trypsin inhibitor, trypsinogen-bovine pancreatic trypsin inhibitor, and trypsinogen-isoleucylvaline-bovine pancreatic trypsin inhibitor.	Hydrogen	0-8	trophoblast Kunitz domain protein 1	Bos taurus	114-131
3300283-3	1987	We have used 1H NMR to monitor directly the release of arginine from bradykinin.	Hydrogen	13-15	kininogen 1	Homo sapiens	69-79
2440473-0	1987	Hydrogen exchange kinetics of bovine pancreatic trypsin inhibitor beta-sheet protons in trypsin-bovine pancreatic trypsin inhibitor, trypsinogen-bovine pancreatic trypsin inhibitor, and trypsinogen-isoleucylvaline-bovine pancreatic trypsin inhibitor.	Hydrogen	0-8	trophoblast Kunitz domain protein 1	Bos taurus	114-131
2440473-1	1987	Hydrogen exchange rates of six beta-sheet peptide amide protons in bovine pancreatic trypsin inhibitor (BPTI) have been measured in free BPTI and in the complexes trypsinogen-BPTI, trypsinogen-Ile-Val-BPTI, bovine trypsin-BPTI, and porcine trypsin-BPTI.	Hydrogen	0-8	trophoblast Kunitz domain protein 1	Bos taurus	85-102
3593697-0	1987	pH dependence of individual tryptophan N-1 hydrogen exchange rates in lysozyme and its chemically modified derivatives.	Hydrogen	43-51	lysozyme	Homo sapiens	70-78
3593697-1	1987	Nuclear magnetic resonance analyses have been made of the individual hydrogen-deuterium exchange rates of tryptophan indole N-1 hydrogens in native lysozyme and its chemically modified derivatives including lysozyme with an ester cross-linkage between Glu-35 and Trp-108, lysozyme with an internal amide cross-linking between the epsilon-amino group of Lys-13 and the alpha-carboxyl group of Leu-129, and lysozyme with the beta-aspartyl sequence at Asp-101.	Hydrogen	69-77	lysozyme	Homo sapiens	148-156
3593697-1	1987	Nuclear magnetic resonance analyses have been made of the individual hydrogen-deuterium exchange rates of tryptophan indole N-1 hydrogens in native lysozyme and its chemically modified derivatives including lysozyme with an ester cross-linkage between Glu-35 and Trp-108, lysozyme with an internal amide cross-linking between the epsilon-amino group of Lys-13 and the alpha-carboxyl group of Leu-129, and lysozyme with the beta-aspartyl sequence at Asp-101.	Hydrogen	128-137	lysozyme	Homo sapiens	148-156
3801586-0	1986	Evidence for a folded structure of Met-enkephalin in membrane mimetic systems: 1H-nmr studies in sodiumdodecylsulfate, lyso-phosphatidylcholine, and mixed lyso-phosphatidylcholine/sulfatide micelles.	Hydrogen	79-81	proopiomelanocortin	Homo sapiens	35-49
3030818-2	1987	The interaction between horse cytochrome c and the tryptic fragment of bovine liver microsomal cytochrome b5 in the absence and presence of [Cr(ethylenediamine)3]Cl3 was studied by 1H NMR spectroscopy.	Hydrogen	181-183	cytochrome b5 type A	Bos taurus	95-108
3032288-0	1987	[The use of 1H-NMR-spectroscopy for the study of peptide degradation by angiotensin-converting enzyme].	Hydrogen	12-14	angiotensin I converting enzyme	Homo sapiens	72-101
3105851-10	1987	Thus carbonic anhydrase III inhibition with sodium cyanate increased the effect of hypercapnia implying that carbonic anhydrase III assists in the regulation of free hydrogen ion concentration in slow-twitch skeletal muscle.	Hydrogen	166-174	carbonic anhydrase 3	Mus musculus	5-27
3105851-10	1987	Thus carbonic anhydrase III inhibition with sodium cyanate increased the effect of hypercapnia implying that carbonic anhydrase III assists in the regulation of free hydrogen ion concentration in slow-twitch skeletal muscle.	Hydrogen	166-174	carbonic anhydrase 3	Mus musculus	109-131
3305117-1	1987	De-Nol (colloidal bismuth subcitrate, CBS) precipitates in an acid environment and adheres to the exudate layer covering an ulcer crater; moreover, CBS blocks pepsin activity, retards hydrogen-ion back-diffusion and stimulates prostaglandin synthesis.	Hydrogen	184-192	cystathionine beta-synthase	Homo sapiens	148-151
3539595-5	1986	EF-1 beta, the factor enhancing the EF-1 alpha GDP/GTP exchange, is part of EF-1H and of smaller aggregates.	Hydrogen	79-81	eukaryotic translation elongation factor 1 beta 2	Bos taurus	0-9
3539595-10	1986	The property of EF-1 beta to aggregate with other proteins suggests that this factor plays an important role in the organization of EF-1H.	Hydrogen	135-137	eukaryotic translation elongation factor 1 beta 2	Bos taurus	16-25
3596900-2	1987	The conformation in aqueous solution of several alpha-aminoisobutyric acid (AIB)-containing analogs of bradykinin (BK) has been probed by complementary CD and 1H n.m.r.	Hydrogen	159-161	kininogen 1	Homo sapiens	103-113
3596900-2	1987	The conformation in aqueous solution of several alpha-aminoisobutyric acid (AIB)-containing analogs of bradykinin (BK) has been probed by complementary CD and 1H n.m.r.	Hydrogen	159-161	kininogen 1	Homo sapiens	115-117
3596900-6	1987	Bradykinin and [AIB7]-BK adopt similar hydrogen bonded conformations in TFE, apparently with a contribution from a beta-turn involving their common Arg1-Pro2-Pro3-Gly4 moiety.	Hydrogen	39-47	kininogen 1	Homo sapiens	0-10
3596900-6	1987	Bradykinin and [AIB7]-BK adopt similar hydrogen bonded conformations in TFE, apparently with a contribution from a beta-turn involving their common Arg1-Pro2-Pro3-Gly4 moiety.	Hydrogen	39-47	kininogen 1	Homo sapiens	22-24
3576729-3	1987	Highly molecular aggregates of fibrinogen are found to be produced mainly due to hydrogen bonds.	Hydrogen	81-89	fibrinogen beta chain	Homo sapiens	31-41
2441070-0	1987	Hydrogen exchange kinetics of surface peptide amides in bovine pancreatic trypsin inhibitor.	Hydrogen	0-8	trophoblast Kunitz domain protein 1	Bos taurus	74-91
3803596-1	1987	Using sugar and methylation analyses, and one- and two-dimensional 1H-NMR spectroscopy at 500 MHz it was established that poly-beta-1,2-4-deoxy-D-arabinohexopyranose occurs as O-specific chains of lipopolysaccharides in Citrobacter serotypes O4, O27 and O36.	Hydrogen	67-69	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	127-135
2831430-1	1987	The activity (mean +/- SD) of galactose-1-phosphate uridyl transferase in two long-term lymphoid cell lines from Caucasian patients with transferase deficiency galactosaemia, a heterozygote, and eight normal subjects was 0, 78 and 168 +/- 55 nmol UDPG consumed (mg protein)-1h-1, respectively.	Hydrogen	274-276	galactose-1-phosphate uridylyltransferase	Homo sapiens	30-70
3746811-4	1986	The 4-alkyl compounds, in contrast, formed a pyridine derivative in which a hydrogen atom was present at the 4-position and the alkyl group was lost; these compounds also inactivated cytochrome P-450 and caused the loss of nifedipine oxidase activity after enzymatic oxidation.	Hydrogen	76-84	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	223-241
3023086-0	1986	A 1H-NMR study of human interleukin-1 beta.	Hydrogen	2-4	interleukin 1 beta	Homo sapiens	24-42
3096150-0	1986	Effects of parathyroid hormone and urinary phosphate on collecting duct hydrogen secretion.	Hydrogen	72-80	parathyroid hormone	Rattus norvegicus	11-30
3023247-0	1986	Assignment and conformation of neurotensin in aqueous solution by 1H NMR.	Hydrogen	66-68	neurotensin	Homo sapiens	31-42
3023247-2	1986	To detect formation of a secondary structure, the effects of peptide fragmentation, temperature decrease, pH changes and addition of denaturing agents on the neurotensin 1H NMR spectrum were investigated.	Hydrogen	170-172	neurotensin	Homo sapiens	158-169
3098173-0	1986	Mechanism of the glycine cleavage reaction: retention of C-2 hydrogens of glycine on the intermediate attached to H-protein and evidence for the inability of serine hydroxymethyltransferase to catalyze the glycine decarboxylation.	Hydrogen	61-70	myosin binding protein H like	Gallus gallus	114-123
3463530-2	1986	infusion of angiotensin II-induced arterial hypertension using hydrogen clearance method.	Hydrogen	63-71	angiotensinogen	Rattus norvegicus	12-26
3748680-4	1986	The change in hydrogen ion concentration in milk was associated with corresponding changes throughout lactation in the concentration of citrate but not with the concentration of lactose.	Hydrogen	14-22	Weaning weight-maternal milk	Bos taurus	44-48
3748680-7	1986	Milk samples from ruminants were found to have concentrations of hydrogen ions and citrate that are greater than and pH that is less than the respective measurements in human milk.	Hydrogen	65-73	Weaning weight-maternal milk	Bos taurus	0-4
2874096-3	1986	The potency of inhibitory activity of H2-antagonists on acetylcholinesterase estimated from median inhibitory dose were in the following order of decreasing activity: ranitidine greater than TZU-0460 greater than cimetidine greater than YM-11170, whereas that on pseudocholinesterase were TZU-0460 greater than ranitidine greater than cimetidine greater than YM-11170.	Hydrogen	38-40	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-76
3020619-0	1986	Stereoselective hydrogen abstraction in leukotriene A4 synthesis by purified 5-lipoxygenase of porcine leukocytes.	Hydrogen	16-24	arachidonate 5-lipoxygenase	Homo sapiens	77-91
2424497-0	1986	Two-dimensional 1H NMR of three spin-labeled derivatives of bovine pancreatic trypsin inhibitor.	Hydrogen	16-18	trophoblast Kunitz domain protein 1	Bos taurus	78-95
2482748-0	1986	One- and two-dimensional 1H NMR study of the substance P fragment ARG-PRO-Lys-Pro.	Hydrogen	25-27	tachykinin precursor 1	Homo sapiens	45-56
3012557-4	1986	Leukotriene A4 synthase stereospecifically eliminated the D-hydrogen at C-10 (pro-R) in the synthesis of leukotriene A4 when incubated with [10D-3H;3-(14)C]5-HPETE.	Hydrogen	60-68	chemokine (C-C motif) ligand 6	Mus musculus	72-76
3701787-19	1986	Furthermore, substitution of an inhibitor with a 2-hydroxymethyl group (or other hydrogen-bonding substituent) and a 2,3-double bond may lend auspicious binding properties to the molecule for GABA-T.	Hydrogen	81-89	4-aminobutyrate aminotransferase	Homo sapiens	192-198
3515467-0	1986	Interaction between laminin, fibronectin and the light chain of the H2 complex.	Hydrogen	68-70	fibronectin 1	Homo sapiens	29-40
2869789-2	1986	1H nuclear magnetic resonance has been used to show that oxmetidine binds to a single site on the regulatory calcium-binding protein, calmodulin.	Hydrogen	0-2	calmodulin 1	Homo sapiens	134-144
3718546-0	1986	[Study of bradykinin conformation in a dimethylsulfoxide solution by two-dimensional 1H-NMR spectroscopy].	Hydrogen	85-87	kininogen 1	Homo sapiens	10-20
3956734-1	1986	Met5-enkephalin-a pentapeptide (Tyr-Gly-Gly-Phe-Met)-can exist in two possible folded arrangements with a rigid two-hydrogen-bonded network.	Hydrogen	116-124	proenkephalin	Homo sapiens	5-17
2417837-1	1986	The three-dimensional structure of substance P has been studied by 1H-NMR, (500 MHz), and by circular dichroism (CD) in different solvents.	Hydrogen	67-69	tachykinin precursor 1	Homo sapiens	35-46
3030032-0	1986	Interaction of haemoglobin and cytochrome c with aliphatic alcohols as studied by 1H NMR spectroscopy.	Hydrogen	82-84	cytochrome c, somatic	Homo sapiens	31-43
2423027-5	1986	The profound effects of H2 antagonists on gastrin action may also reflect an effect mediated by histamine release, but this possibility awaits direct confirmation.	Hydrogen	24-26	gastrin	Canis lupus familiaris	42-49
3959350-0	1986	Divalent cation dependent conformations of brain calmodulin detected by 1H NMR.	Hydrogen	72-74	calmodulin 1	Homo sapiens	49-59
3959350-1	1986	The effects of the Ca2+, Mg2+, Zn2+, Cd2+, Hg2+ and Mn2+ on the conformation of calmodulin (CaM) have been tested by using 400 MHz 1H NMR.	Hydrogen	131-133	calmodulin 1	Homo sapiens	80-90
3959350-1	1986	The effects of the Ca2+, Mg2+, Zn2+, Cd2+, Hg2+ and Mn2+ on the conformation of calmodulin (CaM) have been tested by using 400 MHz 1H NMR.	Hydrogen	131-133	calmodulin 1	Homo sapiens	92-95
3810700-7	1986	In particular, 2-D nmr COSY 45 experiments, affording full 1H line assignments, have rigorously established the "natural" beta (axial) configuration of the C-10 hydrogen in the 19-nor lactones 5a and 8, and therefore also in the related 4a, 6a and 19-noraldosterone 7.	Hydrogen	59-61	homeobox C10	Homo sapiens	156-160
3810700-7	1986	In particular, 2-D nmr COSY 45 experiments, affording full 1H line assignments, have rigorously established the "natural" beta (axial) configuration of the C-10 hydrogen in the 19-nor lactones 5a and 8, and therefore also in the related 4a, 6a and 19-noraldosterone 7.	Hydrogen	161-169	homeobox C10	Homo sapiens	156-160
2420035-5	1986	The results are believed to support hydrogen bonding at C-10 as a contributing factor in the binding of tetrodotoxin to the membrane receptor.	Hydrogen	36-44	homeobox C10	Homo sapiens	56-60
3916340-3	1985	We propose that the solute determines the behaviour of the adjacent first interfacial water layer (I1); that the bulk solution determines the behaviour of the third interfacial water layer (I3), and that both I1 and I3 compete for hydrogen-bonding interactions with the intervening water layer (I2), which can be thought of as a transition layer.	Hydrogen	231-239	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	209-218
4084591-1	1985	The dark binding of 8-methoxypsoralen (MOP) to d(pApT)4 was investigated by 270-MHz 1H nuclear magnetic resonance (NMR) spectra.	Hydrogen	84-86	poly(A) polymerase beta	Homo sapiens	49-53
3907704-14	1985	This has been attributed to preferential stabilization of the SN1 transition state by an interplay of hydrogen-bonding and nonbonding interactions between the phosphoryl group and the protein.	Hydrogen	102-110	solute carrier family 38 member 3	Homo sapiens	62-65
4076183-0	1985	Assignment of resonances in the 1H NMR spectrum of human lysozyme.	Hydrogen	32-34	lysozyme	Homo sapiens	57-65
4076183-1	1985	Assignments in the 1H NMR spectrum for more than 120 resonances arising from 38 of the 130 amino acid residues of human lysozyme are presented.	Hydrogen	19-21	lysozyme	Homo sapiens	120-128
4043385-3	1985	1H-NMR spectroscopy also showed differences in the molecular properties of fibronectin and its 180 kDa fragment.	Hydrogen	0-2	fibronectin 1	Homo sapiens	75-86
2414451-0	1985	Hydrogen kinetics of peptide amide protons at the bovine pancreatic trypsin inhibitor protein-solvent interface.	Hydrogen	0-8	trophoblast Kunitz domain protein 1	Bos taurus	68-85
2414451-1	1985	Hydrogen exchange rate constants of the 25 most rapidly exchanging peptide amide protons in bovine pancreatic trypsin inhibitor have been determined over a range of pH that spans pH min, the pH of minimum rate.	Hydrogen	0-8	trophoblast Kunitz domain protein 1	Bos taurus	110-127
2996648-6	1985	While CSL and 5-PC both reflect the high ordering of the bilayer close to the lipid-water interface, CSL appears to be located close enough to the water for the nitroxide to be involved in hydrogen bonding with water molecules.	Hydrogen	189-197	chorionic somatomammotropin hormone like 1	Homo sapiens	101-104
4074702-8	1985	The 1H NMR spectrum of isocitrate dehydrogenase at pH 7.5 has three narrow peaks between delta 7.85 and 7.69 that shift with changes in pH and hence arise from C-4 protons of histidines.	Hydrogen	4-6	complement C4-A	Sus scrofa	160-163
4079926-0	1985	[Determination and comparative analysis of the conformation of bovine pancreatic trypsin inhibitor and trypsin inhibitors E and K from the data of two-dimensional 1H-NMR spectroscopy].	Hydrogen	163-165	trophoblast Kunitz domain protein 1	Bos taurus	81-98
4062995-1	1985	2D 1H-NMR spectra of des-Gly9-[Arg8]vasopressin in dimethylsulfoxide have been taken and the 1H resonances have been assigned.	Hydrogen	3-5	arginine vasopressin	Homo sapiens	36-47
4074501-3	1985	The hemiketal complex of thrombin and p-APPA may be further stabilized by a hydrogen bond between a carboxylate oxygen of p-APPA and the N tau-atom (= N epsilon 2) of His57, as was previously shown for the trypsin-p-APPA complex by X-ray crystal structure analysis by J. Walter and W. Bode.	Hydrogen	76-84	coagulation factor II, thrombin	Homo sapiens	25-33
4079926-2	1985	The diagram was used for the determination of backbone conformations of bovine pancreatic trypsin inhibitor and trypsin inhibitors E and K from Dendroaspis polylepis using the data from two-dimensional 1H-NMR spectroscopy.	Hydrogen	202-204	trophoblast Kunitz domain protein 1	Bos taurus	90-107
2989285-4	1985	Interestingly, the pH dependence of the Em indicated that the overall redox reactions of the enzyme was: ferric myeloperoxidase + 2e- + 1H+ = ferrous myeloperoxidase.	Hydrogen	136-138	myeloperoxidase	Homo sapiens	112-127
4066150-4	1985	The HS-CH2CH2CO group was introduced onto the synthetic neurokinin A by reaction of 3-(S-acetyl-thiopropionyl)-thiazolidine-2-thione, followed by deacetylation with hydroxylamine.	Hydrogen	4-6	tachykinin precursor 1	Homo sapiens	56-68
2989285-4	1985	Interestingly, the pH dependence of the Em indicated that the overall redox reactions of the enzyme was: ferric myeloperoxidase + 2e- + 1H+ = ferrous myeloperoxidase.	Hydrogen	136-138	myeloperoxidase	Homo sapiens	150-165
2984947-7	1985	These results are consistent with the view that changes in intracellular hydrogen ion and/or anion concentration can selectively inhibit the increase in water permeability elicited by vasopressin at a step(s) distal to the generation of cAMP.	Hydrogen	73-81	arginine vasopressin	Homo sapiens	184-195
3924910-3	1985	It is found that substitution of one SH hydrogen at the G alpha-subunit by N-ethylmaleimide or thionitrobenzoate still allows dark binding of the G-unit to the membrane but blocks its light binding to rhodopsin.	Hydrogen	40-48	rhodopsin	Homo sapiens	201-210
3936597-1	1985	The primary structural analysis of O- and N-linked carbohydrate chains of the C-1-esterase inhibitor purified from normal serum was carried out by 400-MHz 1H-NMR spectroscopy.	Hydrogen	155-157	complement C1s	Homo sapiens	78-90
3923562-6	1985	The results are interpreted on the basis that hydrogen removal by the lipoxygenase is from C10 and by the cyclooxygenase from C13 but only in 20:35,11,14 are these hydrogens (C13) located at the center of a 1,4 cis cis pentadiene system (ethylenic) or a 1,4 pentadiyne system (acetylenic).	Hydrogen	46-54	homeobox C10	Homo sapiens	91-94
3839023-0	1985	Solution conformation of proteinase inhibitor IIA from bull seminal plasma by 1H nuclear magnetic resonance and distance geometry.	Hydrogen	78-80	endogenous retrovirus group K member 25	Homo sapiens	25-35
3978078-0	1985	Hydrogen exchange of lysozyme powders.	Hydrogen	0-8	lysozyme	Homo sapiens	21-29
3978078-2	1985	The rate of exchange of the labile hydrogens of lysozyme was measured by out-exchange of tritium from the protein in solution and from powder samples of varied hydration level, for pH 2, 3, 5, 7, and 10 at 25 degrees C. The dependence of exchange of powder samples on the level of hydration was the same for all pHs.	Hydrogen	35-44	lysozyme	Homo sapiens	48-56
3978078-14	1985	The order was pH independent and was constant from 114 to 8 mol of hydrogen remaining unexchanged/mol of lysozyme.	Hydrogen	67-75	lysozyme	Homo sapiens	105-113
2981643-4	1985	Binding to cytochrome P-450 was studied by spectroscopic measurements (optical difference spectra with microsomal fractions); base-catalyzed deuterium exchange of alpha-hydrogen atoms was followed by 1H n.m.r.	Hydrogen	200-202	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	11-27
6150639-7	1984	Marketed and investigational H2-antagonist drugs differ in their ability to inhibit drug metabolism due to the combined characteristics of cytochrome P-450 binding affinity and therapeutic dosage.	Hydrogen	29-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	139-155
6093872-0	1984	Spectral and kinetic abnormality during the reduction of cytochrome c3 catalyzed by hydrogenase with hydrogen.	Hydrogen	84-92	cytochrome c, somatic	Homo sapiens	57-69
6093872-1	1984	Reduction process of cytochrome c3 by hydrogenase (EC 1.12.2.1) under H2 was analyzed by means of spectrophotometry.	Hydrogen	70-72	cytochrome c, somatic	Homo sapiens	21-33
6084164-6	1984	This weak hydrogen bonding situation allows the methylation by protein methylases of a precursor chromatin protein that after methylation by the S-adenosyl-L-methionine which is base-paired to the specific DNA site, conformationally is set or locked into place and acts as a specific repressor for the alpha-fetoprotein gene.	Hydrogen	10-18	alpha fetoprotein	Homo sapiens	302-319
6442108-4	1984	The rate constant was independent of hydrogen ion concentration between pH 5.8 and 7.3; above pH 7.3 it increased in magnitude with increasing pH, and was 2.0 X 10(8) M-1 s-1 at pH 8.4.	Hydrogen	37-45	tumor associated calcium signal transducer 2	Homo sapiens	167-174
6725284-0	1984	The structure of the carbohydrate units of human plasma galactoglycoprotein determined by 500-megahertz 1H NMR spectroscopy.	Hydrogen	104-106	sialophorin	Homo sapiens	56-75
6477969-8	1984	The 1H and 13C resonance assignments of the majority of metabolites present in RIF-1 extracts have also been made.	Hydrogen	4-6	replication timing regulatory factor 1	Mus musculus	79-84
6465896-1	1984	Second-order absorption spectra strongly suggest the presence of a hydrogen bond between the single Trp of human pituitary growth hormone (hGH) and a carboxylate ion.	Hydrogen	67-75	growth hormone 1	Homo sapiens	113-137
6208354-3	1984	However, cells cultured with 10(-5) M dimaprit showed more than an 80% decrease in their cAMP response to subsequent addition of H2 agonists, whereas the cAMP response to prostaglandin E2 was unaltered.	Hydrogen	129-131	cathelicidin antimicrobial peptide	Homo sapiens	89-93
6428447-2	1984	Two intermediates have been detected on the major slow-refolding pathway of RNase A: a late intermediate (IN) which already resembles the native protein in a number of properties and a rapidly formed early intermediate (I1) which shows extensive hydrogen-bonded secondary structure.	Hydrogen	246-254	ribonuclease pancreatic	Bos taurus	76-83
6326400-6	1984	The inhibition of the acetylcholinesterase activity by H2-antagonists is of no practical relevance.	Hydrogen	55-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-42
6372787-12	1984	(6) The results support the view that (+/-)-BCH stimulates insulin secretion via a primary enhancement of hydrogen supply to the respiratory chain of B-cell mitochondria.	Hydrogen	106-114	chimerin 2	Mus musculus	44-47
6400816-7	1984	The two UpA molecules are hydrogen-bonded together by Watson-Crick type base pairing.	Hydrogen	26-34	proline rich acidic protein 1	Homo sapiens	8-11
6722127-4	1984	Proton nuclear magnetic resonance (1H NMR) studies of peptides comprising the amino- or carboxy-terminal half of CaM reveal the great structural similarity between these two proteolytic fragments and the intact protein.	Hydrogen	35-37	calmodulin 1	Homo sapiens	113-116
6708051-0	1984	In situ preparation and fate of cis-4-hydroxycyclophosphamide and aldophosphamide: 1H and 31P NMR evidence for equilibration of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and its hydrate in aqueous solution.	Hydrogen	83-85	suppressor of cytokine signaling 6	Homo sapiens	32-37
6708051-1	1984	cis-4-Hydroxycyclophosphamide (2) and aldophosphamide (4) were generated in aqueous phosphate or cacodylate buffer by dimethyl sulfide reduction of cis-4-hydroperoxycyclophosphamide (8) and by sodium periodate cleavage of 3,4-dihydroxybutyl N,N-bis(2-chloroethyl)phosphorodiamidate (9), respectively; the reactions of 2 and 4 were examined by 1H and 31P NMR.	Hydrogen	343-345	suppressor of cytokine signaling 6	Homo sapiens	0-5
6708051-1	1984	cis-4-Hydroxycyclophosphamide (2) and aldophosphamide (4) were generated in aqueous phosphate or cacodylate buffer by dimethyl sulfide reduction of cis-4-hydroperoxycyclophosphamide (8) and by sodium periodate cleavage of 3,4-dihydroxybutyl N,N-bis(2-chloroethyl)phosphorodiamidate (9), respectively; the reactions of 2 and 4 were examined by 1H and 31P NMR.	Hydrogen	343-345	suppressor of cytokine signaling 6	Homo sapiens	148-153
6421314-1	1984	Complexes formed between apolipoprotein A-I (apo A-I) and dimyristoylphosphatidylcholine (DMPC) or egg phosphatidylcholine have been studied by high-field 1H NMR, nondenaturing gradient gel electrophoresis, electron microscopy, and gel filtration chromatography.	Hydrogen	155-157	apolipoprotein A1	Homo sapiens	25-43
6321458-1	1984	The dissimilatory nitrite reductase (cytochrome c,d1) from Pseudomonas aeruginosa was observed at pH 7.5 to catalyze nitrosyl transfer (nitrosation) between [15N]nitrite and several N-nucleophiles or H2 18O, with rate enhancement of the order of 10(8) relative to analogous chemical reactions.	Hydrogen	200-202	cytochrome c, somatic	Homo sapiens	37-49
6421314-1	1984	Complexes formed between apolipoprotein A-I (apo A-I) and dimyristoylphosphatidylcholine (DMPC) or egg phosphatidylcholine have been studied by high-field 1H NMR, nondenaturing gradient gel electrophoresis, electron microscopy, and gel filtration chromatography.	Hydrogen	155-157	apolipoprotein A1	Homo sapiens	45-52
6697987-0	1984	1H NMR studies of calmodulin.	Hydrogen	0-2	calmodulin 1	Homo sapiens	18-28
6372687-6	1984	In cells with high hydrogenase activity the----H+/O,----H+/NO2- and----H+/NO3- values with hydrogen as the electron donor were 3.74, 2.61 and 4.36 respectively.	Hydrogen	19-27	NBL1, DAN family BMP antagonist	Homo sapiens	74-77
6697987-2	1984	Two tryptic fragments of the Ca2+ -binding protein calmodulin have been studied by high-resolution 1H NMR.	Hydrogen	99-101	calmodulin 1	Homo sapiens	51-61
6089236-5	1984	In a study employing 1H-nuclear magnetic resonance, the spectrum changes of the aromatic region of CaM induced by prenylamine were significantly more marked than the changes induced by W-7.	Hydrogen	21-23	calmodulin 1	Homo sapiens	99-102
6315524-6	1984	Instillation of acetylsalicylic acid (36 mM, 1300 mg) in 200 ml of 100 mM hydrochloric acid for just 15 min resulted in a mean net hydrogen ion loss of 3.4 mmol/15 min, a net sodium ion gain of 1.9 mmol/15 min, a decrease in the potential difference of 23 mV, and marked gastric mucosal changes.	Hydrogen	131-139	ETS transcription factor ELK3	Homo sapiens	127-130
6440265-9	1984	The NADPH-cytochrome c (P450) reductase of G6PD-deficient HL and HSF homogenates becomes lower than that of controls when endogenous G6PD and exogenous glucose 6-phosphate (G6P) and NADP+ are used as a hydrogen donor system in place of NADPH.	Hydrogen	202-210	interleukin 6	Homo sapiens	65-68
6193789-2	1983	By 1H-NMR spectroscopy it has been shown that Substance P is largely aggregated at basic and acid pH and in saline solutions.	Hydrogen	3-5	tachykinin precursor 1	Homo sapiens	46-57
6653776-2	1983	The structural stability of calmodulin was studied by 1H-nuclear magnetic resonance spectroscopy under different denaturing conditions.	Hydrogen	54-56	calmodulin 1	Homo sapiens	28-38
6654875-1	1983	The 270 MHz 1H NMR spectra of 3"-UMP and 3"-CMP were observed in the presence of a two-fold molar excess of bovine pancreatic RNase A [EC 3.1.27.5] at various pHs.	Hydrogen	12-14	ribonuclease pancreatic	Bos taurus	126-133
6579545-1	1983	A normal mode analysis making use of an empirical potential function including local and nonlocal (nonbonded) interactions is performed for the bovine pancreatic trypsin inhibitor in the full conformational space of the molecule (1,740 degrees of freedom); that is, all bond lengths and angles, as well as dihedral angles, are included for the 580-atom system consisting of all heavy atoms and polar hydrogens.	Hydrogen	400-409	trophoblast Kunitz domain protein 1	Bos taurus	162-179
6626573-0	1983	The use of two-dimensional correlated spectroscopy to obtain new assignments in the high-resolution 1H nuclear magnetic resonance spectrum of the biantennary complex oligosaccharide isolated from human serum transferrin by hydrazinolysis.	Hydrogen	100-102	transferrin	Homo sapiens	208-219
6312971-2	1983	The interaction between eukaryotic cytochrome c and the tryptic fragment of bovine liver microsomal cytochrome b5 was studied by 1H-n.m.r.	Hydrogen	129-131	cytochrome b5 type A	Bos taurus	100-113
6884343-0	1983	A 113Cd and 1H NMR study of the interaction of calmodulin with D600, trifluoperazine and some other hydrophobic drugs.	Hydrogen	12-14	calmodulin 1	Homo sapiens	47-57
6884343-1	1983	The interaction of calmodulin with D600 (a methoxy derivative of verapamil), trifluoperazine and some other drugs was studied by 113Cd and 1H NMR.	Hydrogen	139-141	calmodulin 1	Homo sapiens	19-29
24221647-4	1983	Utilization of(3)H2 by N2 fixers was mainly dark-mediated, whereas(3)H2 utilization associated with periods of NO3 (})- abundance revealed an increasing dependence on light.	Hydrogen	69-71	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
6307694-0	1983	Investigation by photochemically-induced dynamic nuclear polarization and nuclear Overhauser enhancement 1H-NMR of the interaction between beta-endorphin and phospholipid micelles.	Hydrogen	105-107	proopiomelanocortin	Homo sapiens	139-153
24221647-6	1983	Conversely, NO3 (})- stimulated(3)H2 utilization among N2 and non-N2 fixing genera, particularly under illuminated conditions.	Hydrogen	34-36	NBL1, DAN family BMP antagonist	Homo sapiens	12-15
6863249-7	1983	An additional hydrogen bond can be formed by bridging of the epsilon-amino group of beta-66 (Lys) between a heme propionate from cytochrome b5 and a beta-chain heme propionate.	Hydrogen	14-22	amyloid beta precursor protein	Homo sapiens	147-153
6863249-5	1983	A fourth hydrogen bond involves alpha-61 (Lys) bridging between a heme propionate from cytochrome b5 and a heme propionate from the alpha-chain.	Hydrogen	9-17	Fc gamma receptor and transporter	Homo sapiens	132-143
6296095-2	1983	Experiments with mastocytoma cells showed that a hydrogen is stereospecifically eliminated from C-10 during the conversion of eicosapentaenoic acid to leukotriene C5.	Hydrogen	49-57	homeobox C10	Homo sapiens	96-100
6296095-0	1983	Stereospecific elimination of hydrogen at C-10 in eicosapentaenoic acid during the conversion to leukotriene C5.	Hydrogen	30-38	homeobox C10	Homo sapiens	42-46
6854645-1	1983	The 1H nuclear magnetic resonance spectrum of alpha-tropomyosin contains a number of sharp peaks indicative of the presence of small regions of high flexibility in the molecule.	Hydrogen	4-6	tropomyosin 1	Homo sapiens	46-63
6407471-2	1983	Since Drosophila alcohol dehydrogenase (ADH) uses NAD+ to remove a hydrogen from ethanol in the first step of alcohol catabolism, it is possible that under alcohol stress conditions the in vivo NAD+ levels in Drosophila may decrease.	Hydrogen	27-35	Alcohol dehydrogenase	Drosophila melanogaster	40-43
6301552-0	1983	A 1H-NMR longitudinal relaxation study of the interaction between cytochrome c and cytochrome c oxidase.	Hydrogen	2-4	cytochrome c, somatic	Homo sapiens	66-78
6301552-0	1983	A 1H-NMR longitudinal relaxation study of the interaction between cytochrome c and cytochrome c oxidase.	Hydrogen	2-4	cytochrome c, somatic	Homo sapiens	83-95
6301552-1	1983	The interaction between the oxidized forms of cytochrome c and cytochrome c oxidase (EC 1.9.3.1) has been investigated by 1H-NMR longitudinal relaxation measurements.	Hydrogen	122-124	cytochrome c, somatic	Homo sapiens	46-58
6301552-1	1983	The interaction between the oxidized forms of cytochrome c and cytochrome c oxidase (EC 1.9.3.1) has been investigated by 1H-NMR longitudinal relaxation measurements.	Hydrogen	122-124	cytochrome c, somatic	Homo sapiens	63-75
6296095-5	1983	This indicates that oxygenation of the acid at C-5 occurred before the elimination of hydrogen and suggests that removal of the pro-S hydrogen at C-10 in 5-hydroperoxy-6,8,11,14,17-eicosapentaenoic acid initiates its transformation to trans-5(S),6(S)-oxido-7,9-trans-11,14,17-cis-eicosapentaenoic acid (leukotriene A5).	Hydrogen	134-142	homeobox C10	Homo sapiens	146-150
6312977-3	1983	These differences were provoked by an additional effect of the precursors of syntheses studied, i.e. lactate or ornithine, on the hydrogen supply of the respiratory chain, as was reflected in terms of the reduction degree of cytochrome c in isolated mitochondria.	Hydrogen	130-138	cytochrome c, somatic	Homo sapiens	225-237
6186300-1	1982	High-resolution 270 MHZ 1H-nuclear magnetic resonance spectroscopy has been used to follow the interaction of myristoyllysophosphatidylcholine with bovine myelin basic protein.	Hydrogen	24-26	myelin basic protein	Bos taurus	155-175
6139293-2	1983	Prolactin release was markedly increased by the H2-histamine agonists, 4-methyl histamine and Dimaprit.	Hydrogen	48-50	prolactin	Rattus norvegicus	0-9
7160490-0	1982	Solution conformation of the biantennary N-linked oligosaccharide of human serotransferrin using 1H NMR nuclear Overhauser effect measurements.	Hydrogen	97-99	transferrin	Homo sapiens	75-90
7160490-1	1982	The conformation in solution of the biantennary complex type oligosaccharide unit derived from human serotransferrin has been investigated using 1H-1H Nuclear Overhauser Effect (NOE) measurements at 300 MHz.	Hydrogen	145-147	transferrin	Homo sapiens	101-116
6291601-0	1982	Effect of hydrogen ion concentration on rhodopsin-lipid interactions.	Hydrogen	10-18	rhodopsin	Homo sapiens	40-49
7150538-1	1982	The conformation of troponin C (TN-C) isolated from the white muscle of pike (Esox lucius), in the Ca2+ and metal-free states, was studied by circular dichroism, absorption difference spectroscopy, solvent perturbation difference spectroscopy, intrinsic fluorescence, thiol titration, and 1H nuclear magnetic resonance spectroscopy.	Hydrogen	289-291	tenascin	Esox lucius	20-30
6297982-4	1982	Incubation of the doubly labeled arachidonic acids with human platelets confirmed and extended previous data on the stereochemistry of the hydrogen removal from C-10 during the conversion into 12(S)-hydroperoxy-5cis,8cis,10trans,14cis-eicosatetraenoic acid, i.e., the 10L (pro-S)-hydrogen is eliminated and the 10D (pro-R)-hydrogen retained.	Hydrogen	139-147	homeobox C10	Homo sapiens	161-165
6297982-4	1982	Incubation of the doubly labeled arachidonic acids with human platelets confirmed and extended previous data on the stereochemistry of the hydrogen removal from C-10 during the conversion into 12(S)-hydroperoxy-5cis,8cis,10trans,14cis-eicosatetraenoic acid, i.e., the 10L (pro-S)-hydrogen is eliminated and the 10D (pro-R)-hydrogen retained.	Hydrogen	280-288	homeobox C10	Homo sapiens	161-165
6292423-2	1982	Analysis of the binding affinity of these compounds to the uterine estrogen receptor, measured by competitive binding assay, reveals trends that can be related to the steric size, the hydrophobicity, and the hydrogen bond accepting character of the side-chain substituents.	Hydrogen	208-216	estrogen receptor 1	Homo sapiens	67-84
6288661-8	1982	The membrane cytochromes were reduced by hydrogen in the presence of 2-heptyl-4-hydroxyquinoline-N-oxide at concentrations which prevented the reduction of cytochrome c with succinate as the electron donor.	Hydrogen	41-49	cytochrome c, somatic	Homo sapiens	156-168
7084616-6	1982	Mean hydrogen production from substrates containing less than 3% sugar (human serum albumin, bovine serum albumin, and alpha-casein) averaged 2.2 +/- 0.9% of hydrogen production from equivalent amounts of glucose, while carbohydrate-rich mucin yielded 46.0 +/- 6.7% of hydrogen production from glucose.	Hydrogen	5-13	albumin	Homo sapiens	78-91
7138878-3	1982	Biochemical and 1H-NMR techniques were used to characterize the new inhibitor, which is referred to as PSTI III.	Hydrogen	16-18	serine peptidase inhibitor Kazal type 1	Homo sapiens	103-107
7084616-6	1982	Mean hydrogen production from substrates containing less than 3% sugar (human serum albumin, bovine serum albumin, and alpha-casein) averaged 2.2 +/- 0.9% of hydrogen production from equivalent amounts of glucose, while carbohydrate-rich mucin yielded 46.0 +/- 6.7% of hydrogen production from glucose.	Hydrogen	5-13	albumin	Homo sapiens	100-113
7084616-6	1982	Mean hydrogen production from substrates containing less than 3% sugar (human serum albumin, bovine serum albumin, and alpha-casein) averaged 2.2 +/- 0.9% of hydrogen production from equivalent amounts of glucose, while carbohydrate-rich mucin yielded 46.0 +/- 6.7% of hydrogen production from glucose.	Hydrogen	158-166	albumin	Homo sapiens	78-91
7084616-6	1982	Mean hydrogen production from substrates containing less than 3% sugar (human serum albumin, bovine serum albumin, and alpha-casein) averaged 2.2 +/- 0.9% of hydrogen production from equivalent amounts of glucose, while carbohydrate-rich mucin yielded 46.0 +/- 6.7% of hydrogen production from glucose.	Hydrogen	158-166	albumin	Homo sapiens	78-91
6979541-0	1982	Re-examination of rhodopsin structure by hydrogen exchange.	Hydrogen	41-49	rhodopsin	Homo sapiens	18-27
6979541-1	1982	The hydrogen exchange behavior of rhodopsin was re-examined by studies of the protein in the disc membrane and after solubilization in octyl glucoside.	Hydrogen	4-12	rhodopsin	Homo sapiens	34-43
7106112-2	1982	Ca2+-induced conformational changes of calmodulin under a variety of different experimental conditions have been studied by 1H-nuclear magnetic resonance techniques.	Hydrogen	124-126	calmodulin 1	Homo sapiens	39-49
6807102-0	1982	Importance of molecular size and hydrogen bonding in vasopressin-stimulated urea transport.	Hydrogen	33-41	arginine vasopressin	Homo sapiens	53-64
6279843-2	1982	It was concluded that the interaction involves a hydrogen bond from a donor site on ACE to the oxygen of the amide carbonyl.	Hydrogen	49-57	angiotensin I converting enzyme	Homo sapiens	84-87
7078422-7	1982	Our results have shown that the GIP response to betazole is maintained in achlorhydric subjects as well as during H2 blockade.	Hydrogen	114-116	gastric inhibitory polypeptide	Homo sapiens	32-35
7060566-0	1982	270-MHz 1H nuclear-magnetic-resonance study of met-enkephalin in solvent mixtures.	Hydrogen	8-10	proopiomelanocortin	Homo sapiens	47-61
7060566-2	1982	1H spectra at 270 MHz of zwitterionic Met-enkephalin pentapeptide (Tyr-Gly-Gly-Phe-Met) in (C2H3)2SO/water mixtures are reported and discussed in terms of solvent-induced conformational transitions.	Hydrogen	0-2	proopiomelanocortin	Homo sapiens	38-52
7074022-0	1982	Assignment and interpretation of hydrogen out-of-plane vibrations in the resonance Raman spectra of rhodopsin and bathorhodopsin.	Hydrogen	33-41	rhodopsin	Homo sapiens	100-109
6172148-5	1981	The DLeu2 substitution is considered to interfere with the head to head hydrogen bonding which forms the conducting dimer, thus destabilizing the dimeric structure of the channel and reducing the lifetime.	Hydrogen	72-80	deleted in lymphocytic leukemia 2	Homo sapiens	4-9
6803827-0	1982	pH and temperature effects on the molecular conformation of the porcine pancreatic secretory trypsin inhibitor as detected by hydrogen-1 nuclear magnetic resonance.	Hydrogen	126-134	serine peptidase inhibitor Kazal type 1	Homo sapiens	72-110
6803827-1	1982	1H NMR spectra of the porcine pancreatic secretory trypsin inhibitor (PSTI) have been recorded vs. pH and temperature.	Hydrogen	0-2	serine peptidase inhibitor Kazal type 1	Homo sapiens	30-68
6803827-1	1982	1H NMR spectra of the porcine pancreatic secretory trypsin inhibitor (PSTI) have been recorded vs. pH and temperature.	Hydrogen	0-2	serine peptidase inhibitor Kazal type 1	Homo sapiens	70-74
7248274-2	1981	The peptide amide hydrogen exchange rate of human angiotensin II in H2O have been measured at room temperature by the transfer of solvent saturation method.	Hydrogen	18-26	angiotensinogen	Homo sapiens	50-64
7035679-0	1981	1H nuclear magnetic resonance study of the histidine residues of insulin.	Hydrogen	0-2	insulin	Homo sapiens	65-72
6268745-0	1981	A study of the electron transfer properties of the heme undecapeptide from cytochrome c by 1H nmr spectroscopy.	Hydrogen	91-93	cytochrome c, somatic	Homo sapiens	75-87
7262046-4	1981	Insulin responsiveness in vivo was estimated by means of a 1h-insulin infusion test (two 30-min.	Hydrogen	59-61	insulin	Homo sapiens	0-7
7262046-4	1981	Insulin responsiveness in vivo was estimated by means of a 1h-insulin infusion test (two 30-min.	Hydrogen	59-61	insulin	Homo sapiens	62-69
7202730-0	1981	A study of calmodulin and its interaction with trifluoperazine by high resolution 1H NMR spectroscopy.	Hydrogen	82-84	calmodulin 1	Homo sapiens	11-21
7192710-10	1981	In particular, this may induce a stronger hydrogen bonding within the lysozyme which would in turn increase both the pKa of certain amino acid residues and the helical content of the macromolecule.	Hydrogen	42-50	lysozyme	Homo sapiens	70-78
7008840-0	1981	Hydrogen-1 and carbon-13 nuclear magnetic resonance of the aromatic residues of fd coat protein.	Hydrogen	0-8	golgi phosphoprotein 3	Homo sapiens	83-95
7008840-1	1981	The aromatic residues of fd coat protein in sodium dodecyl sulfate micelles are characterized by 1H and 13C NMR.	Hydrogen	97-99	golgi phosphoprotein 3	Homo sapiens	28-40
6460690-0	1981	H-2 effects on cell-cell interactions in the response to single non-H2 alloantigens.	Hydrogen	68-70	histocompatibility-2, MHC	Mus musculus	0-3
7308590-3	1981	Gastrin and PP release were stimulated by a meal or bombesin nonapeptide infusion (1.2 microgram kg-1h-1).	Hydrogen	100-102	gastrin	Canis lupus familiaris	0-7
6254977-4	1980	The 1H NMR spectra of the octopus calmodulin and bovine brain calmodulin are compared in their apo- and calcium-saturated conformations.	Hydrogen	4-6	calmodulin	Bos taurus	34-44
7029165-5	1981	However, the larger, non-proliferating, late-passage cells were producing fibronectin, 1h determined by radioimmunoassay of the medium.	Hydrogen	87-89	fibronectin 1	Homo sapiens	74-85
6283492-5	1981	We have, together with A. Holmgren and A. Ehrnberg, made observations suggesting the presence in rate liver cytosol of an enzyme which catalyzes the reductive reactivation of oxidized CCK with reduced thioredoxin as the immediate hydrogen donor.	Hydrogen	230-238	cholecystokinin	Homo sapiens	184-187
7036106-4	1981	On the basis of this observation, the tritium labeling of GnRH and angiotensin I by direct catalytic hydrogen-tritium exchange was found to be useful for the labeling of these peptides at remarkably high specific radioactivity.	Hydrogen	101-109	angiotensinogen	Homo sapiens	67-80
7255870-3	1981	Unlike mouse however, where only H2 receptors are observed, the histamine inhibition of rat vas deferens was attenuated by both H1, (diphenhydramine) and H2 (cimetidine) antagonists.	Hydrogen	33-35	arginine vasopressin	Rattus norvegicus	92-95
6254977-4	1980	The 1H NMR spectra of the octopus calmodulin and bovine brain calmodulin are compared in their apo- and calcium-saturated conformations.	Hydrogen	4-6	calmodulin	Bos taurus	62-72
6254977-6	1980	1H NMR and UV difference spectroscopy also demonstrate that the solution conformations of the apo- and calcium-saturated forms of octopus calmodulin are very similar to those of bovine brain calmodulin.	Hydrogen	0-2	calmodulin	Bos taurus	138-148
6250619-5	1980	The length of the DNA polymerase beta product was comparable to the anticipated length of the DNA region within which the hydrogen bonds were disrupted owing to dimer formation.	Hydrogen	122-130	DNA polymerase beta	Bos taurus	18-37
7459349-3	1980	On the basis of selective enzymatic and partial acid hydrolysis and 1H and 31P NMR studies, Man5P was shown to have the structure P leads to 6 alpha Man1 leads to 3 alpha Man1 leads to 2 alpha Man1 leads to 2 alpha Man1 leads to 2Man (where Man = D-mannopyranose).	Hydrogen	68-70	LEM domain containing 3	Homo sapiens	171-175
7459349-3	1980	On the basis of selective enzymatic and partial acid hydrolysis and 1H and 31P NMR studies, Man5P was shown to have the structure P leads to 6 alpha Man1 leads to 3 alpha Man1 leads to 2 alpha Man1 leads to 2 alpha Man1 leads to 2Man (where Man = D-mannopyranose).	Hydrogen	68-70	LEM domain containing 3	Homo sapiens	171-175
7459349-3	1980	On the basis of selective enzymatic and partial acid hydrolysis and 1H and 31P NMR studies, Man5P was shown to have the structure P leads to 6 alpha Man1 leads to 3 alpha Man1 leads to 2 alpha Man1 leads to 2 alpha Man1 leads to 2Man (where Man = D-mannopyranose).	Hydrogen	68-70	LEM domain containing 3	Homo sapiens	171-175
6257303-0	1980	1H-NMR studies of the coordination geometry at the heme iron and the electronic structure of the heme group in cytochrome c-552 from Euglena gracilis.	Hydrogen	0-2	cytochrome c, somatic	Homo sapiens	111-123
6257303-1	1980	The 1H-NMR lines of heme c in reduced and oxidized cytochrome c-552 from Euglena gracilis were individually assigned and the coordination geometry of the axial ligands was investigated.	Hydrogen	4-6	cytochrome c, somatic	Homo sapiens	51-63
7248461-0	1980	Hydrogen isotope exchange kinetics of single protons in bovine pancreatic trypsin inhibitor.	Hydrogen	0-8	trophoblast Kunitz domain protein 1	Bos taurus	74-91
6787293-4	1980	The addition of the haptoglobin inhibited two heme-dependent reactions catalyzed by a purified enzyme of seminal vesicle microsome, i.e., the prostaglandin G2 synthesis from arachidonic acid and the conversion of prostaglandin G2 to H2.	Hydrogen	233-235	haptoglobin	Rattus norvegicus	20-31
7359538-2	1980	[5-(N4,N4-Dimethylasparagine),8-lysine]vasopressin, the analogue in which the hydrogen atoms of the -NH2 portion of the primary carboxamide have been replaced by methyl groups, has been synthesized and found to retain about 3% of the antidiuretic potency of lysine-vasopressin (i.e., 5.5 +/- 0.3 units/mg).	Hydrogen	78-86	arginine vasopressin	Rattus norvegicus	39-50
6248792-6	1980	Light and hydrogen are the two other convenient energy sources that could be used for such reductions, and we now report the reduction of cytochrome c by these means.	Hydrogen	10-18	cytochrome c, somatic	Homo sapiens	138-150
6157233-4	1980	The structure of cholesta-5,8-dien-3 beta-ol was attributed to this compound by mass spectrometric, 1H, and 13C NMR analysis.	Hydrogen	100-102	integrin subunit beta 1	Rattus norvegicus	37-44
7352997-1	1980	High-field (270 MHz) 1H-NMR has been employed to study the solution conformation of glycophorin A, a sialoglycoprotein which spans the human erythrocyte membrane.	Hydrogen	21-23	glycophorin A (MNS blood group)	Homo sapiens	84-97
7255197-2	1980	The method involves the use of kinetic secondary alpha-hydrogen isotope effects which are expected to accompany sp2 to sp3 rehybridization of C-6 of the pyrimidine ring if they occur prior to or at the rate determining step.	Hydrogen	55-63	Sp3 transcription factor	Homo sapiens	119-122
7417590-1	1980	Hydrogen isotope exchange of crystalline lysozyme.	Hydrogen	0-8	lysozyme	Homo sapiens	41-49
6254725-7	1980	The oxy-analogs to the C7, C10, and C13 conformations and structures containing bifurcated hydrogen bonds are also discussed.	Hydrogen	91-99	homeobox C10	Homo sapiens	27-30
6153638-2	1980	CD spectra of substance P (SP) and its C-terminal partial sequences have been measured in diluted aqueous solution including variation of hydrogen ion concentration.	Hydrogen	138-146	tachykinin precursor 1	Homo sapiens	14-25
7352983-2	1980	These are based on 15 sets of crystal coordinates of lysozyme and over 60 assigned resonances in the 1H nuclear magnetic resonance (NMR) spectrum of lysozyme.	Hydrogen	101-103	lysozyme	Homo sapiens	149-157
7352983-8	1980	Applications of these calculations are described to compare the tetragonal and triclinic forms of native lysozyme, to propose several assignments of 1H NMR signals in the spectrum of lysozyme, and to analyze some of the conformational changes which occur on the binding of Gd(III) and GlcNAc sugars to lysozyme.	Hydrogen	149-151	lysozyme	Homo sapiens	183-191
7352983-8	1980	Applications of these calculations are described to compare the tetragonal and triclinic forms of native lysozyme, to propose several assignments of 1H NMR signals in the spectrum of lysozyme, and to analyze some of the conformational changes which occur on the binding of Gd(III) and GlcNAc sugars to lysozyme.	Hydrogen	149-151	lysozyme	Homo sapiens	183-191
7255197-2	1980	The method involves the use of kinetic secondary alpha-hydrogen isotope effects which are expected to accompany sp2 to sp3 rehybridization of C-6 of the pyrimidine ring if they occur prior to or at the rate determining step.	Hydrogen	55-63	Sp2 transcription factor	Homo sapiens	112-115
518847-1	1979	Proton and carbon-13 nuclear magnetic resonance (1H and 13C NMR) spectra of rhodopsin-phospholipid membrane vesicles and sonicated disk membranes are presented and discussed.	Hydrogen	49-51	rhodopsin	Homo sapiens	76-85
6928653-0	1980	Amino acid side chain conformation in angiotensin II and analogs: correlated results of circular dichroism and 1H nuclear magnetic resonance.	Hydrogen	111-113	angiotensinogen	Homo sapiens	38-52
42316-5	1979	The hydrosmotic responses elicited by serosal hypertonicity or cyclic AMP plus theophylline were also affected by mucosal or serosal changes of the hydrogen in concentration, suggesting an effect at a post-cyclic AMP level.	Hydrogen	148-156	adenine phosphoribosyltransferase	Homo sapiens	70-73
42316-5	1979	The hydrosmotic responses elicited by serosal hypertonicity or cyclic AMP plus theophylline were also affected by mucosal or serosal changes of the hydrogen in concentration, suggesting an effect at a post-cyclic AMP level.	Hydrogen	148-156	adenine phosphoribosyltransferase	Homo sapiens	213-216
520321-0	1979	1H nuclear-magnetic-resonance studies of the porcine-pancreatic secretory trypsin inhibitor at 270 MHz.	Hydrogen	0-2	serine peptidase inhibitor Kazal type 1	Homo sapiens	53-91
520321-1	1979	The pancreatic secretory trypsin inhibitor from porcine pancreas has been investigated by high-resolution 1H nuclear magnetic resonance (NMR) at 270 MHz.	Hydrogen	106-108	serine peptidase inhibitor Kazal type 1	Homo sapiens	4-42
41741-0	1979	Resolution of specific histidine resonances in the 360 MHz 1H NMR spectrum of glyceraldehyde-3-phosphate dehydrogenase, a 145 000 molecular weight protein, by photo-CIDNP.	Hydrogen	59-61	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	78-118
528014-0	1979	Mobility and symmetry in the Fc and pFc" fragments as probed by 1H NMR.	Hydrogen	64-66	complement factor properdin	Homo sapiens	36-40
222328-6	1979	91, 2801) but also the reversible oxidoreduction of the electron carrier, cytochrome c3 with H2.	Hydrogen	93-95	cytochrome c, somatic	Homo sapiens	74-86
224872-0	1979	Hydrogen transfer from 4-R and 4-S (4-3H) NADH in the reduction of d,l-cis-6,7-dimethyl-6,7 (8H) dihydropterin with dihydropteridine reductase from human liver and sheep liver.	Hydrogen	0-8	quinoid dihydropteridine reductase	Homo sapiens	116-142
435461-4	1979	The configurational purity of tritium at C-2 of dopamine and C-1 of the dopamine precursor 3-methoxy-4-hydroxyphenethylamine has been confirmed employing dopamine-beta-hydroxylase (specific for the pro-R hydrogen at C-2) and pea seedling amine oxidase (specific for the pro-S hydrogen at C-1).	Hydrogen	204-212	dopamine beta-hydroxylase	Bos taurus	154-179
37078-0	1979	270-MHz 1H nuclear-magnetic-resonance study of Met-enkephalin in water.	Hydrogen	8-10	proopiomelanocortin	Homo sapiens	47-61
229911-0	1979	Individual assignments of the heme resonances in the 360 MHz 1H NMR spectra of cytochrome c-557 from Crithidia oncopelti.	Hydrogen	61-63	cytochrome c, somatic	Homo sapiens	79-91
229911-1	1979	With the use of nuclear Overhauser effects, spin decoupling and saturation transfer experiments individual assignments for numerous resonances of the heme group in the 360 MHz 1H NMR spectra of reduced and oxidized cytochrome c-557 from Crithidia oncopelti were obtained.	Hydrogen	176-178	cytochrome c, somatic	Homo sapiens	215-227
222328-8	1979	The rate of oxidoreduction of cytochrome c3 in the dry state was 0.015 mol H2 taken up in the forward reaction and 0.003 mol H2 released in the reverse reaction per mol hydrogenase per s. The process of these reactions could be explained by the observations that the hydrogenase molecule in the dry state has protons which are directly exchangeable with H2 during catalytic process.	Hydrogen	75-77	cytochrome c, somatic	Homo sapiens	30-42
222328-8	1979	The rate of oxidoreduction of cytochrome c3 in the dry state was 0.015 mol H2 taken up in the forward reaction and 0.003 mol H2 released in the reverse reaction per mol hydrogenase per s. The process of these reactions could be explained by the observations that the hydrogenase molecule in the dry state has protons which are directly exchangeable with H2 during catalytic process.	Hydrogen	125-127	cytochrome c, somatic	Homo sapiens	30-42
470930-1	1979	A new family of insulin secretogogues that resemble glucose in hydrogen bonding possibilities.	Hydrogen	63-71	insulin	Homo sapiens	16-23
429110-3	1979	Three types of such hydrogen bonded conformations, designated A1, A2 and B, are possible, involving some amount of strain on the bond angles.	Hydrogen	20-28	BCL2 related protein A1	Homo sapiens	62-74
510217-4	1979	The hydrogen bond directionality observed in T4 and other thyroid structures offers an insight into the molecular details of the hormone-receptor site.	Hydrogen	4-12	nuclear receptor subfamily 4 group A member 1	Homo sapiens	129-145
220604-5	1979	The effect of a change in hydrogen bond geometry is studied by employing x-ray coordinates for reduced and oxidized cytochrome c, deoxy- and metmyoglobin, and deoxy- and methemoglobin.	Hydrogen	26-34	cytochrome c, somatic	Homo sapiens	116-128
569493-0	1978	Hydrogen bonds in serine proteinases and their complexes with protein proteinase inhibitors.	Hydrogen	0-8	endogenous retrovirus group K member 25	Homo sapiens	25-35
26982-0	1978	Cation and hydrogen ion effect on canine acid and gastrin output.	Hydrogen	11-19	gastrin	Canis lupus familiaris	50-57
279920-2	1978	The catalase (hydrogen-peroxide:hydrogen-peroxide oxidoreductase, EC 1.11.1.6) that was synthesized was isolated by immunoprecipitation and characterized by electrophoresis in sodium dodecyl sulfate/polyacrylamide gels followed by fluorography.	Hydrogen	14-22	catalase	Rattus norvegicus	4-12
28153-5	1978	Under conditions ruling out complex-formation of lysozyme with the inhibitors (N-acetylglucosamine and its dimer) the electrons are localized on disulphide bonds of the protein molecules at alkaline pH and at pH less than or equal to 3 the radicals are observed which are due to the remove of hydrogen atom from the Calpha-atom of the protein polypeptide chain.	Hydrogen	293-301	lysozyme	Homo sapiens	49-57
743909-0	1978	[Role of lipids in the thermostability of rhodopsin in photoreceptor membranes by the technic of 1H NMR spectroscopy].	Hydrogen	97-99	rhodopsin	Homo sapiens	42-51
209821-6	1978	The self-exchange reaction of cobalt cytochrome c was investigated with pulsed Fourier transform 1H NMR.	Hydrogen	97-99	cytochrome c, somatic	Homo sapiens	37-49
626780-1	1978	Shifts in the system of GABA transformation in ischemia and specific inhibition of GABA-transaminase under conditions of quantitative measurement of the blood circulation by means of hydrogen clearance permitted to establish a definite association between the increased GABA level in the brain and the tissues of the wall of its arteries, and the development of compensation of disturbed cerebral circulation.	Hydrogen	183-191	4-aminobutyrate aminotransferase	Homo sapiens	83-100
28141-0	1978	13C and 1H nuclear magnetic resonance studies of bradykinin and selected peptide fragments.	Hydrogen	8-10	kininogen 1	Homo sapiens	49-59
275827-1	1978	A beta bulge is a region between two consecutive beta-type hydrogen bonds which includes two residues (positions 1 and 2) on one strand opposite a single residue (position x) on the other strand.	Hydrogen	59-67	amyloid beta precursor protein	Homo sapiens	0-6
21190-0	1977	Hydrogen exchange study of membrane-bound rhodopsin.	Hydrogen	0-8	rhodopsin	Homo sapiens	42-51
598499-0	1977	The hydrophobic heart of rhodopsin revealed by an infrared 1H-2H exchange study.	Hydrogen	59-61	rhodopsin	Homo sapiens	25-34
21190-3	1977	Hydrogen exchange studies of rhodopsin in disc membranes demonstrated that photolysis induces changes in the protein itself.	Hydrogen	0-8	rhodopsin	Homo sapiens	29-38
21190-8	1977	The unusually large fraction of exposed peptide hydrogens observed previously for rhodopsin is unaltered in the photolyzed forms.	Hydrogen	48-57	rhodopsin	Homo sapiens	82-91
838535-0	1977	A note on the two-dimensional representation of hydrogen bonding scheme in triose phosphate isomerase.	Hydrogen	48-56	triosephosphate isomerase 1	Homo sapiens	75-101
19247-1	1977	The amino groups of insulin have been studied by 1H and 13C nuclear magnetic resonance spectroscopy in insulin, zinc-free insulin and methylated insulin.	Hydrogen	49-51	insulin	Homo sapiens	20-27
911876-2	1977	Hydrogen-deuterium exchange kinetics of (Asn1-Val5) angiotensin II has been investigated by proton magnetic resonance at 250 MHz in deuterated trifluoroethanol, as an approach to the "in situ" hormone conformation.	Hydrogen	0-8	angiotensinogen	Homo sapiens	52-66
18271-0	1977	Effect of parathyroid hormone on renal excretion of sodium and hydrogen ions.	Hydrogen	63-71	parathyroid hormone	Homo sapiens	10-29
880336-1	1977	Deuteron spin-lattice relaxation times of specifically labelled methyl N-acetyl-D-glucosaminides associated to lysozyme were measured from 1H and 2H NMR spectra through bandshape analysis and FT inversion-recovery technique, respectively.	Hydrogen	139-141	lysozyme	Homo sapiens	111-119
12822-0	1977	Stereospecificity of the hydrogen transfer catalyzed by human placental aldose reductase.	Hydrogen	25-33	aldo-keto reductase family 1 member B	Homo sapiens	72-88
557997-1	1977	Analogs of L-tryptophane with modified alpha-amino groups (substituted for hydrogen or keto-group, or acylated) are competitive reversible inhibitors of the aminoacylation of tRNNATrp catalyzed by tryptophanyl-tRNA synthetase from beef pancreas.	Hydrogen	75-83	tryptophanyl-tRNA synthetase 1	Homo sapiens	197-225
838535-1	1977	When the backbone hydrogen bonding scheme of the protein triose phosphate isomerase is represented in the two-dimensional map where the donor residue number (i) is taken along the x-axis and the acceptor residue number (j) is taken along the y-axis, the (i, j)-map shows a characteristic pattern of (beta alpha)8-super-secondary structure.	Hydrogen	18-26	triosephosphate isomerase 1	Homo sapiens	57-83
844942-8	1977	The data from the two sets of experiments suggest that hydrogen bonds and salt linkages rather than hydrophobic interactions are the main factor in the binding of bilirubin to its primary site on HSA.	Hydrogen	55-63	albumin	Homo sapiens	196-199
12111-4	1976	A peptide chloromethyl ketone elastase inhibitor abolished both elastolytic activity and the pctentiating effects on MPO-H2-O2-mediated bacterial killing.	Hydrogen	121-123	myeloperoxidase	Homo sapiens	117-120
853743-0	1977	Exchange of hydrogen at C21 during dehydroxylation of deoxycorticosterone by mixed cultures of human fecal flora.	Hydrogen	12-20	TBL1X/Y related 1	Homo sapiens	24-27
999836-1	1976	The effect of isotopic substitution of the specifically labilized hydrogen in the substrates of triosephosphate isomerase on the steady-state rates of the enzyme-catalyzed reaction has been examined.	Hydrogen	66-74	triosephosphate isomerase 1	Homo sapiens	96-121
1002819-6	1976	The observed effects of the hydrogen and calcium ions on suppressing renin release may be secondary to their known actions on renal sodium excretion.	Hydrogen	28-36	renin	Homo sapiens	69-74
1002819-7	1976	Since the infusions of calcium and hydrogen ions both result in an increased delivery of sodium to the distal segment of the nephron, the results may reflect the regulation of renin by the macula densa, a sensitive intrarenal sensor of renal tubular sodium.	Hydrogen	35-43	renin	Homo sapiens	176-181
11212-0	1976	Hydrogen ion interactions of horse spleen ferritin and apoferritin.	Hydrogen	0-8	ferritin heavy chain	Equus caballus	55-66
2474-0	1976	A study of the lysyl residues in the basic pancreatic trypsin inhibitor using 1H nuclear magnetic resonance at 360 Mhz.	Hydrogen	78-80	trophoblast Kunitz domain protein 1	Bos taurus	54-71
186319-0	1976	Structural studies of cytochrome c-551 by 1H NMR spectroscopy at 360 MHz.	Hydrogen	42-44	cytochrome c, somatic	Homo sapiens	22-34
955101-0	1976	Hydrogen-tritium exchange of rhodopsin: effect of solvent on the incorporation of slowly exchanging tritium atoms.	Hydrogen	0-8	rhodopsin	Homo sapiens	29-38
14504-4	1976	In the other group (group 2) the patients had a mean plasma renin activity of 2.1 ng ml-1h-1 (range 1.1 to 5.1) and were considered to have normal to high renin hypertension.	Hydrogen	88-90	renin	Homo sapiens	60-65
932041-4	1976	The labeled glycine was incubated with D-amino acid oxidase, an enzyme which, in the catalysis of the conversion of glycine to glyoxylic acid, specifically removes the hydrogen in the S configuration at carbon atom 2 of glycine.	Hydrogen	168-176	D-amino-acid oxidase	Rattus norvegicus	39-59
16592314-1	1976	The abundance parameter, log gfA, where g is the statistical weight of the lower level, f is the oscillator strength, and A is the abundance (by numbers of atoms with respect to hydrogen), has been derived for three lines of osmium by a method of spectrum synthesis.	Hydrogen	178-186	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	29-32
10620-1	1976	Cimetidine infusion (100 mg h-1) reduced the acid secretory response to insulin infusion (0.03 units Kg-1h-1) when compared to paired control tests in 6 healthy volunteers.	Hydrogen	104-106	insulin	Homo sapiens	72-79
1225592-0	1975	Hydrogen-deuterium exchange of angiotensin II in trifluoroethanol.	Hydrogen	0-8	angiotensinogen	Homo sapiens	31-45
2905-2	1975	It was found that formation of a 2 : 2 Sn : PyP complex, which is bone seeking, is depending as well on the pyrophosphate as on the hydrogen ion concentration in the equilibrium.	Hydrogen	132-140	inorganic pyrophosphatase 1	Rattus norvegicus	44-47
2905-3	1975	On the contrary, formation of a 2 : 1 Sn : PyP complex, which shows no bone affinity but concentrate in the kidneys, is hydrogen ion independent and occurs even at very low pyrophosphate concentrations.	Hydrogen	120-128	inorganic pyrophosphatase 1	Rattus norvegicus	43-46
240438-0	1975	Hydrogen ion titration of lysozyme in alcohol-water solutions.	Hydrogen	0-8	lysozyme	Homo sapiens	26-34
238589-0	1975	Hydrogen-tritium exchange kinetics of soybean trypsin inhibitor (Kunitz).	Hydrogen	0-8	kunitz trypsin protease inhibitor	Glycine max	46-63
1175685-5	1975	The catalase-induced inhibition was not affected by scavenging of thiol groups; this rules out, as a mechanism of action of catalase, the increased destruction of popoperoxides by glutathione peroxidase, which requires reduced glutathione as hydrogen donor.	Hydrogen	242-250	catalase	Homo sapiens	4-12
238589-2	1975	The hydrogen exchange kinetics of Kunitz soybean trypsin inhibitor (STI) has been studied at pH 2, 3, and 6.5.	Hydrogen	4-12	kunitz trypsin protease inhibitor	Glycine max	49-66
164901-10	1975	The role of the catalytic Co(II) thus appears to be the activation of a hydroxyl or water ligand which polarizes the aldehyde carbonyl group by hydrogen bonding.	Hydrogen	144-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
237755-6	1975	To examine stereospecific transfer of the hydrogen from NADPH to androstenedione by the purified 17 beta-hydroxysteroid dehydrogenase, the following tritiated cofactors were synthesized: [4-3-H]NADP+ was prepared by catalytic replacement from non-radioactive NADP+ and 3H2O in the presence of potassium cyanide.	Hydrogen	42-50	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	97-133
1902-2	1975	In oxidation of NADP.H2 there were at least three point of molecular O2 reduction: NADP.H2-specific flavoprotein, Fe2+ participating in reactions of peroxidation of unsaturated fatty acids and cytochrome P-450.	Hydrogen	21-23	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	193-209
1199634-6	1975	However, the l-rRNA of all the protostomian animals and the protozoa is an aggregate molecule consisting of two subunits held together by limited regions of hydrogen bounding; in these organisms the size of the s-rRNA is generally identical to that of the larger fragment of the l-rRNA.	Hydrogen	157-165	mitochondrially encoded 16S RNA	Homo sapiens	13-19
166765-0	1975	[Influence of the oxidoreductive state on the kinetics of deuterium-hydrogen exchange in cytochrome c].	Hydrogen	68-76	cytochrome c, somatic	Homo sapiens	89-101
1122315-13	1975	Total lipoprotein lipase activity of cells plus medium increased steadily during incubation of fat cells for 1h at 30 degrees C. The major increment occurred in the cells and activity in the medium was always less than 15% of the total.	Hydrogen	109-111	lipoprotein lipase	Rattus norvegicus	6-24
237241-4	1975	This result is compatible with a proposed hypothesis that the calcium mobilizing function of the parathyroid hormone may be enhanced by the hormone"s own influence on systemic hydrogen ion concentration.	Hydrogen	176-184	parathyroid hormone	Rattus norvegicus	97-116
5063533-0	1972	Hydrogen-deuterium exchange of lysozyme.	Hydrogen	0-8	lysozyme	Homo sapiens	31-39
235176-6	1975	The two 17beta-HSD, after solubilization from the microsomal fraction of human placenta, enrichment and separation from each other, show only a little activity for the transfer of hydrogen between C17 of estradiol-17beta and C17 of androstenedione.	Hydrogen	180-188	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	8-18
4473959-0	1974	Hydrogen ion changes of rhodopsin.	Hydrogen	0-8	rhodopsin	Homo sapiens	24-33
4461263-0	1974	Evidence for the metabolic lability of the C-21 hydrogens of corticosteroids.	Hydrogen	48-57	TBL1X/Y related 1	Homo sapiens	43-47
4646780-2	1972	The supernatant obtained by centrifugation of a rat liver homogenate at 100000g for 1h contained a heat-labile macromolecular inhibitor of the thrombin-fibrinogen reaction.	Hydrogen	84-86	coagulation factor II	Rattus norvegicus	143-151
4475634-0	1974	A comparative study on the basic pancreatic trypsin inhibitor and insulin by the hydrogen-exchange method.	Hydrogen	81-89	insulin	Homo sapiens	66-73
4366962-0	1974	A proposed hydrogen transfer function for cytochrome c.	Hydrogen	11-19	cytochrome c, somatic	Homo sapiens	42-54
4366962-2	1974	The mechanisms, while accommodating the fact that cytochrome c is a net electron acceptor and donor in its catalytic cycle, dictate that the enzyme catalyses hydrogen transfer.	Hydrogen	158-166	cytochrome c, somatic	Homo sapiens	50-62
4506776-1	1972	The peptide amide, primary carboxamide, and aromatic proton resonances were assigned to specific hydrogens of oxytocin and lysine vasopressin (Lys-VP) in water at 23 degrees at pH 2.5 and 4.2, respectively.	Hydrogen	97-106	arginine vasopressin	Homo sapiens	130-141
4625641-0	1972	[Study of the kinetics of hydrogen-deuterium exchange of cytochrome c at 20 and 38 degrees C].	Hydrogen	26-34	cytochrome c, somatic	Homo sapiens	57-69
4675202-0	1972	Hydrogen ion titration study of the histidine residues of horse myoglobin.	Hydrogen	0-8	myoglobin	Equus caballus	64-73
4333981-0	1972	Evidence for the presence of hydrogen-bonded secondary structure in angiotensin II in aqueous solution.	Hydrogen	29-37	angiotensinogen	Homo sapiens	68-82
4333981-1	1972	Automated tritium-hydrogen exchange measurements have been made on the linear octapeptide Val(5)-angiotensin II amide.	Hydrogen	18-26	angiotensinogen	Homo sapiens	97-111
4333981-4	1972	It is concluded that these slow hydrogens in angiotensin II are involved in secondary structure with either one or both forming stable, intramolecular hydrogen bonds.	Hydrogen	32-41	angiotensinogen	Homo sapiens	45-59
4333981-4	1972	It is concluded that these slow hydrogens in angiotensin II are involved in secondary structure with either one or both forming stable, intramolecular hydrogen bonds.	Hydrogen	32-40	angiotensinogen	Homo sapiens	45-59
5419748-0	1970	The stereochemistry of hydrogen elimination from C-7 in cholesterol and ergosterol biosynthesis.	Hydrogen	23-31	complement C7	Rattus norvegicus	49-52
5167780-0	1971	An analysis of a structural difference between beef and pork insulin detected by differences in the exchange rates of amide hydrogens as measured by infrared spectroscopy.	Hydrogen	124-133	insulin	Homo sapiens	61-68
5117568-9	1971	Partial saturation of the catalase intermediate with hydrogen peroxide (p(m)/e) in the mitochondrial fraction suggests its significant peroxidatic activity towards its endogenous hydrogen donor.	Hydrogen	53-61	catalase	Homo sapiens	26-34
5117568-16	1971	A co-ordinated production of both oxidizing and reducing substrates for catalase in the mitochondrial fraction is suggested by a 2.2-fold increase of hydrogen peroxide generation and a threefold increase in hydrogen-donor generation in the State 1 to State 4 transition.	Hydrogen	150-158	catalase	Homo sapiens	72-80
5275374-1	1970	Treatment of deoxycorticosterone with reagents that abstract a hydrogen atom from the C-21-hydroxyl group leads to the formation of androsta-4,16-dien-3-one.	Hydrogen	63-71	TBL1X/Y related 1	Homo sapiens	86-90
5275374-3	1970	This reaction can be formulated as an abstraction of hydrogen from the C-21-hydroxyl group to form a C-21-alkoxy radical, followed by a 1,5-H.shift from the C-16 atom and beta-scission of the C-16-alkoxy radical leading to the loss of a C(2) fragment (C-20 and C-21) with the formation of the double bond between C-16 and C-17.	Hydrogen	53-61	TBL1X/Y related 1	Homo sapiens	71-75
5275374-3	1970	This reaction can be formulated as an abstraction of hydrogen from the C-21-hydroxyl group to form a C-21-alkoxy radical, followed by a 1,5-H.shift from the C-16 atom and beta-scission of the C-16-alkoxy radical leading to the loss of a C(2) fragment (C-20 and C-21) with the formation of the double bond between C-16 and C-17.	Hydrogen	53-61	TBL1X/Y related 1	Homo sapiens	101-105
5275374-3	1970	This reaction can be formulated as an abstraction of hydrogen from the C-21-hydroxyl group to form a C-21-alkoxy radical, followed by a 1,5-H.shift from the C-16 atom and beta-scission of the C-16-alkoxy radical leading to the loss of a C(2) fragment (C-20 and C-21) with the formation of the double bond between C-16 and C-17.	Hydrogen	53-61	TBL1X/Y related 1	Homo sapiens	101-105
5500301-11	1970	However, this shift to 453nm can be explained on the basis of internal hydrogen bonds occurring between the carboxylic protons and the pyrrole rings of bilirubin, as proposed by Fog & Jellum (1963), and new evidence for such a bonding has been accumulated.	Hydrogen	71-79	zinc finger protein, FOG family member 1	Homo sapiens	178-181
4392156-0	1970	Stereochemistry of hydrogen transfer by rat ovary 20 alpha-hydroxysteroid dehydrogenase.	Hydrogen	19-27	aldo-keto reductase family 1, member C3	Rattus norvegicus	50-87
5165783-0	1971	Hydrogen ion titration curve of lysozyme in 6 M guanidine hydrochloride.	Hydrogen	0-8	lysozyme	Homo sapiens	32-40
4252126-0	1971	Difference in conformation of fibrinogen degradation products as revealed by hydrogen exchange and spectropolarimetry.	Hydrogen	77-85	fibrinogen beta chain	Homo sapiens	30-40
5578061-0	1971	[Dependence of prothrombin time on the concentration of calcium and hydrogen ions].	Hydrogen	68-76	coagulation factor II, thrombin	Homo sapiens	15-26
5415685-2	1970	Net hydrogen ion secretion was little affected by amphotericin when passive electrochemical forces across the epithelium were held at a minimum in the short-circuited state under isohydric conditions.	Hydrogen	4-12	ETS transcription factor ELK3	Homo sapiens	0-3
5419748-4	1970	These results therefore suggest that the C-7 hydrogen atoms with opposite stereochemistry are labilized by the rat liver and the yeast Delta(8)-Delta(7) steroid isomerases.	Hydrogen	45-53	complement C7	Rattus norvegicus	41-44
5502292-0	1970	Hydrogen isotope exchange of insulin.	Hydrogen	0-8	insulin	Homo sapiens	29-36
5355345-5	1969	The asparagine residue G10(108)beta lies in the internal cavity of the tetrameric molecule and its main chain carbonyl is thought to be hydrogen bonded to histidine G10(103)alpha at the region of contact between alpha- and beta-chains.	Hydrogen	136-144	Fc gamma receptor and transporter	Homo sapiens	212-234
5729959-0	1968	Coenzyme B12 as hydrogen carrier in the ethanolamine deaminase reaction.	Hydrogen	16-24	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	9-12
5307435-0	1969	Hydrogen ion uptake by oxygen atoms released from rhodopsin molecules on illumination.	Hydrogen	0-8	rhodopsin	Homo sapiens	50-59
5372272-0	1969	Hydrogen-deuterium exchange in insulin.	Hydrogen	0-8	insulin	Homo sapiens	31-38
4304840-0	1969	Evidence for direct hydrogen transfer during glyceraldehyde-3-phosphate dehydrogenase catalysis.	Hydrogen	20-28	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	45-85
4387276-0	1968	Action of insulin and triiodothyronine on energy-controlled pathways of hydrogen.	Hydrogen	72-80	insulin	Homo sapiens	10-17
5666746-0	1968	Hydrogen-deuterium exchange of cytochrome c.	Hydrogen	0-8	cytochrome c, somatic	Homo sapiens	31-43
5691140-0	1968	Hydrogen-deuterium exchange of cytochrome c.	Hydrogen	0-8	cytochrome c, somatic	Homo sapiens	31-43
5639923-5	1968	The location of five of the six labelled hydrogen atoms at C-3, C-9, C-18 and C-19 (two) confirms that the mechanism of cyclization of squalene expected from the biogenetic isoprene rule is functioning in vivo.	Hydrogen	41-49	Bardet-Biedl syndrome 9	Homo sapiens	69-73
6029605-0	1967	The stereochemistry of the hydrogen elimination in the biological conversion of cholest-7-en-3-beta-ol into cholesterol.	Hydrogen	27-35	integrin subunit beta 1	Rattus norvegicus	95-102
6047659-2	1967	The hydrogen ion titration curve of alpha-lactalbumin.	Hydrogen	4-12	lactalbumin alpha	Homo sapiens	36-53
5714494-0	1968	[Action of fasting and insulin on the synthesis of fatty acids beginning with glucose specifically marked with carbon and hydrogen].	Hydrogen	122-130	insulin	Homo sapiens	23-30
18960127-1	1967	A discussion is given of the problem of ascribing dissociation constants in the hypothetical situation in which the protons of the hydroxy groups of TAR and PAR dissociate in the reverse of the normal order, and it is suggested that the o-hydroxy group should be regarded as intrinsically as acidic as the p-hydroxy group, and that the change in pK due to the internal hydrogen "bonding is probably less than one unit.	Hydrogen	369-377	RNA binding motif protein 8A	Homo sapiens	149-152
5833400-0	1965	Hydrogen-ion dependence of the antidiuretic action of vasopressin, oxytocin and deaminooxytocin.	Hydrogen	0-8	arginine vasopressin	Homo sapiens	54-65
5893923-2	1965	Hydrogen bonding of tyrosine residues in the insulin molecule.	Hydrogen	0-8	insulin	Homo sapiens	45-52
13866585-0	1962	[On the effect of hydrogen ion concentration and SH reagents on the redox potential of hemin, equine myoglobin and different hemoglobins].	Hydrogen	18-26	myoglobin	Equus caballus	101-110
14042998-5	1963	On the basis of the results it was postulated that hormone-receptor interaction can be considered a two-step process: (a) The binding or attachment of hormone to receptor site through ionic, hydrogen, and hydrophobic bonds and (b) a disulfide interchange reaction between hormonal disulfide and receptor sulfhydryl.	Hydrogen	191-199	nuclear receptor subfamily 4 group A member 1	Homo sapiens	51-67
13525671-6	1958	The conductance change is regarded as an essential property of rhodopsin, because it occurs in aqueous suspension as well as in digitonin solution; it may be caused by hydrogen or hydroxyl ions and some other conductive substances.	Hydrogen	168-176	rhodopsin	Homo sapiens	63-72
13572348-0	1958	Reactions of catalase with hydrogen peroxide and hydrogen donors.	Hydrogen	27-35	catalase	Homo sapiens	13-21
13772880-0	1961	Deuterium-hydrogen exchange between water and insulin.	Hydrogen	10-18	insulin	Homo sapiens	46-53
13481014-0	1957	Catalase activity in Pediococcus cerevisiae as related to hydrogen ion activity.	Hydrogen	58-66	catalase	Homo sapiens	0-8
13284008-0	1955	[Alkaline phosphomonoesterase activity in sites of direct ossification studies by means of the Gomori method at various hydrogen ion concentrations and at various stages of incubation].	Hydrogen	120-128	alkaline phosphatase, placental	Homo sapiens	1-29
13198919-0	1954	Exchange of hydrogen atoms in insulin with deuterium atoms in aqueous solutions.	Hydrogen	12-20	insulin	Homo sapiens	30-37
13165628-0	1954	Reactions of methaemoglobin and catalase with peroxides and hydrogen donors.	Hydrogen	60-68	catalase	Homo sapiens	32-40
19872498-4	1929	The sap and the dye have been found to poison the usual type of hydrogen electrode.	Hydrogen	64-72	SH2 domain containing 1A	Homo sapiens	4-7
19872889-1	1935	ON THE CONSTANCY OF THE HYDROGEN ION CONCENTRATION DURING THE COAGULATION OF FIBRINOGEN BY THROMBIN.	Hydrogen	24-32	fibrinogen beta chain	Homo sapiens	77-87
19872889-1	1935	ON THE CONSTANCY OF THE HYDROGEN ION CONCENTRATION DURING THE COAGULATION OF FIBRINOGEN BY THROMBIN.	Hydrogen	24-32	coagulation factor II, thrombin	Homo sapiens	91-99
19873444-6	1945	The combination of thrombin with fibrinogen most probably takes place by hydrogen bonds.	Hydrogen	73-81	coagulation factor II, thrombin	Homo sapiens	19-27
19873444-6	1945	The combination of thrombin with fibrinogen most probably takes place by hydrogen bonds.	Hydrogen	73-81	fibrinogen beta chain	Homo sapiens	33-43
33979725-4	2021	And, the binding model from molecular docking analysis of both BSA and AChE with these molecules clearly displayed non-covalent interactions (hydrogen bonding and hydrophobic interactions) which played a significant role in the binding mechanism.	Hydrogen	142-150	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-75
33784543-6	2021	Both synchronous and 3D fluorescence analysis suggested that the microenvironment around tryptophan residues had changed, which coincided with the result of molecular docking that tryptophan residue of alpha-lactalbumin contributed significantly to hydrogen bonding.	Hydrogen	249-257	lactalbumin alpha	Homo sapiens	202-219
33652222-3	2021	This study highlights that DDT can be metabolized by P450 enzymes through the hydrogen abstraction and electrophilic addition mechanism, and the main derivatives are epoxides (2,3-oxide-DDT and 3,4-oxide-DDT), DDE and dicofol.	Hydrogen	78-86	D-dopachrome tautomerase	Homo sapiens	27-30
33515954-6	2021	Furthermore, acidic pH enhanced the binding of salicylic acid to PPO with lower binding energy, additional hydrogen bond and electrostatic interactions.	Hydrogen	107-115	protoporphyrinogen oxidase	Homo sapiens	65-68
33951863-3	2021	According to density functional theory in molecular dynamics simulations, the electrostatic potential and surface charge of the APG-12 and coal molecular models were analyzed to identify their nucleophilic and electrophilic regions, and illustrate the hydrogen bond adsorption mechanism.	Hydrogen	252-260	autophagy related 12	Homo sapiens	128-134
33951863-4	2021	The dynamics simulation results showed that APG-12 molecules can be easily adsorbed on the surface of coal molecules and then adsorb water molecules around them under the action of hydrogen bonds.	Hydrogen	181-189	autophagy related 12	Homo sapiens	44-50
33960375-8	2021	D560N/R468K MBD4 bound to T:G mismatched DNA shows that the side chain amine moiety of the Lys stabilizes the flipped-out thymine by a water-mediated phosphate pinching, while the backbone carbonyl oxygen of the Lys engages in hydrogen bonds with N2 of the estranged guanine.	Hydrogen	227-235	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	12-16
33857841-0	2021	The hydrogen bonding network involved Arg59 in human protoporphyrinogen IX oxidase is essential for enzyme activity.	Hydrogen	4-12	protoporphyrinogen oxidase	Homo sapiens	53-82
33857841-5	2021	In this work, it was proposed that the Arg59 performs its function by forming a hydrogen-bonding (HB) network around it in hPPO, and we investigated the role of the HB network via site-directed mutagenesis, enzymatic kinetics and computational studies.	Hydrogen	80-88	protoporphyrinogen oxidase	Homo sapiens	123-127
33740631-8	2021	An increase in the enzymatic activity of lysozyme in the presence of dalargin was confirmed by a docking model that suggests the formation of hydrogen bonds between dalargin and amino acid residues in the active site.	Hydrogen	142-150	lysozyme	Homo sapiens	41-49
33945286-5	2021	Molecular docking simulations revealed that heMAMP has increased rigidity via hydrogen bonding intramolecularly and improved binding affinity to the active site of MPO.	Hydrogen	78-86	myeloperoxidase	Homo sapiens	164-167
34052293-13	2021	Additionally, hydrogen activated Nrf2 signalling in lung tissues.	Hydrogen	14-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	33-37
34038246-12	2021	Our results predict very strong potential of these four-molecules against SARS-CoV-2 Mpro, especially gamma-glutamyl-S-allylcysteine, as all four form hydrogen bonding with Glu166 that is a crucial residue for the formation of the biologically active dimeric form of Mpro.	Hydrogen	151-159	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	85-89
34038246-12	2021	Our results predict very strong potential of these four-molecules against SARS-CoV-2 Mpro, especially gamma-glutamyl-S-allylcysteine, as all four form hydrogen bonding with Glu166 that is a crucial residue for the formation of the biologically active dimeric form of Mpro.	Hydrogen	151-159	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	267-271
34039987-2	2021	A well-known feature of its phase diagram is that high-temperature phases of ice with orientational disorder of the hydrogen-bonded water molecules undergo phase transitions to their ordered counterparts upon cooling.	Hydrogen	116-124	carboxylesterase 2	Homo sapiens	77-80
34044360-2	2021	The biogas recovered from AD can be upgraded by the methanation of internally produced carbon dioxide, CO2 with externally sourced hydrogen gas, H2 (biomethanation).	Hydrogen	131-139	PAXIP1 associated glutamate rich protein 1	Homo sapiens	7-10
34021361-0	2021	Targeted 1H NMR metabolomics and immunological phenotyping of human fresh blood and serum samples discriminate between healthy individuals and inflammatory bowel disease patients treated with anti-TNF.	Hydrogen	9-11	tumor necrosis factor	Homo sapiens	197-200
33929849-3	2021	The twisted state primarily influences the contacts involving the C-terminus of insulin"s B chain, shifting the registry of its intermolecular hydrogen bonds and reorganizing its side-chain packing.	Hydrogen	143-151	insulin	Homo sapiens	80-87
34037039-8	2021	In addition, molecular docking results confirmed that 25 dipeptides mainly interacted with the core targets (ALB, JAK2, and STAT3) by hydrogen-bonding interactions.	Hydrogen	134-142	albumin	Homo sapiens	109-112
34037039-8	2021	In addition, molecular docking results confirmed that 25 dipeptides mainly interacted with the core targets (ALB, JAK2, and STAT3) by hydrogen-bonding interactions.	Hydrogen	134-142	signal transducer and activator of transcription 3	Homo sapiens	124-129
34021071-6	2021	We also identify a new ligand-mediated hydrogen bonding network that stabilizes the active, ligand-bound conformation of WT-ER LBD, and similarly stabilizes the active conformation of the ER mutants in the hormone-free state.	Hydrogen	39-47	estrogen receptor 1	Homo sapiens	124-126
34021071-6	2021	We also identify a new ligand-mediated hydrogen bonding network that stabilizes the active, ligand-bound conformation of WT-ER LBD, and similarly stabilizes the active conformation of the ER mutants in the hormone-free state.	Hydrogen	39-47	estrogen receptor 1	Homo sapiens	188-190
33851508-6	2021	Coordination environment variation of the active sites, the under-coordinated Mo or W atoms, effectively lowers the work function, making Mo S2 and W S2 highly active for CO methanation with the required potential of -0.47 and -0.49 V vs. reversible hydrogen electrode, respectively.	Hydrogen	250-258	ribosomal protein S2	Homo sapiens	141-152
33719146-2	2021	Herein, we wish to report an example to engage triplet-excited state of allene moiety as hydrogen-atom-transfer (HAT) partner in the activation of remote sp 3 C-H bond via visible-light irradiation under mild reaction conditions with broad substrate scope and good functional-group tolerance.	Hydrogen	89-97	Sp3 transcription factor	Homo sapiens	154-158
33990989-1	2021	Hydrogen dinitrate anion, HNO3 (NO3 - ), is a proton-bound dimer with a very strong hydrogen bond.	Hydrogen	84-92	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
33990989-4	2021	Significant rotations around the hydrogen bond and frequent transfers of proton from HNO3 to NO3 - are observed in AIMD simulations.	Hydrogen	33-41	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
33988174-7	2021	Hs-CRP, LDL-C, and GDF-15 levels were significantly higher in the CAD patients (P=0.091, P=0.008, and P<0.001, respectively).	Hydrogen	0-2	C-reactive protein	Homo sapiens	3-6
33992722-0	2021	Hydrogen alleviated neuronal injury and neuroinflammation induced by microglial activation via the Nrf2 pathway in sepsis-associated encephalopathy.	Hydrogen	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
33977961-9	2021	Molecular docking showed that COS could form hydrogen bonds with the serotonin transporter (SERT) to affect the reuptake of 5-HT in the intercellular space.	Hydrogen	45-53	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	69-90
33980604-4	2021	Substrate pharmacophores for ENT1 and ENT2 are distinct, with partial overlap of hydrogen bond donors, while the inhibitor pharmacophores predominantly feature hydrogen bond acceptors.	Hydrogen	81-89	solute carrier family 29 member 2	Homo sapiens	38-42
33977961-9	2021	Molecular docking showed that COS could form hydrogen bonds with the serotonin transporter (SERT) to affect the reuptake of 5-HT in the intercellular space.	Hydrogen	45-53	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	92-96
33876639-1	2021	A ReCl(CO)5/MeC(CH2PPh2)3 (L2) system was developed for the C-methylation reactions utilizing methanol and base, following the borrowing hydrogen strategy.	Hydrogen	137-145	C-C motif chemokine ligand 28	Homo sapiens	12-15
33965498-5	2021	The procyanidine effectively inhibited the aggregation of hIAPP and Abeta through hydrophobic and hydrogen bonding interactions, it dissolved the aged fibrils into nanoscale particles.	Hydrogen	98-106	amyloid beta precursor protein	Homo sapiens	68-73
33886267-7	2021	In particular, HIV-1 Tat forms hydrogen bond interactions with side chains of hNET residues Y84, K88, and T544.	Hydrogen	31-39	solute carrier family 6 member 2	Homo sapiens	78-82
33412091-4	2021	Hydrogen/deuterium exchange mass spectrometry identifies an allosteric pathway connecting DNA end-binding with the kinase domain that places DNA-PK under tension in the kinase-active state.	Hydrogen	0-8	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	141-147
33886267-8	2021	The favorable hydrogen bonding interactions of HIV-1 Tat with the hNET side chain residues Y84 and T544 have been validated by our subsequently performed DA uptake activity assays and site-directed mutagenesis, suggesting that the modeled HIV-1 Tat-hNET binding mode is reasonable.	Hydrogen	14-22	solute carrier family 6 member 2	Homo sapiens	66-70
33886267-8	2021	The favorable hydrogen bonding interactions of HIV-1 Tat with the hNET side chain residues Y84 and T544 have been validated by our subsequently performed DA uptake activity assays and site-directed mutagenesis, suggesting that the modeled HIV-1 Tat-hNET binding mode is reasonable.	Hydrogen	14-22	solute carrier family 6 member 2	Homo sapiens	249-253
33369126-8	2021	Molecular docking studies demonstrated that SSd can bind to amino acid residues of several key active sites of CYP3A4 protein with hydrogen bonds and hydrophobic interaction.	Hydrogen	131-139	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	111-117
33949102-6	2021	As suggested from molecular docking, the three isomers had strong binding affinity to CYP2D6 via the bonding of hydrogen and van der Waals forces, and the results were in agreement with the fluorescence results.	Hydrogen	112-120	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	86-92
33837859-4	2021	The studied structural units tend to adopt the unique semi-extended beta2 conformation; which is stabilised mainly by N-H NTzl hydrogen bond, and for dehydroamino acids also by pi-electron conjugation.	Hydrogen	127-135	ATPase H+ transporting V0 subunit a2	Homo sapiens	68-73
33866129-13	2021	MD simulations of the Amikacin-Mpro complex suggested the formation of a complex stabilized by hydrogen bonds, salt bridges, and van der Waals interactions.	Hydrogen	95-103	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	31-35
33931852-6	2021	Moreover, fluorescence quenching experiments suggested that the quenching of SPI by AA was static quenching and hydrogen bonds, hydrophobic interactions, and van der Waals forces were involved in this process.	Hydrogen	112-120	chromogranin A	Homo sapiens	77-80
33931646-4	2021	We analyze the currents in two experimentally synthesized gold-based, hydrogen-containing ligand-stabilized nanoclusters [HAu9(PPh3)8]2+ and [PtHAu8(PPh3)8]+.	Hydrogen	70-78	caveolin 1	Homo sapiens	127-131
33599060-6	2021	There are only two of four possible intramolecular hydrogen bonds formed, namely, between Aib4 and Gly1 forming a beta-turn of type III" and between Aib6 and Gly3 forming a beta-turn of type I.	Hydrogen	51-59	amyloid beta precursor protein	Homo sapiens	112-118
33599060-6	2021	There are only two of four possible intramolecular hydrogen bonds formed, namely, between Aib4 and Gly1 forming a beta-turn of type III" and between Aib6 and Gly3 forming a beta-turn of type I.	Hydrogen	51-59	amyloid beta precursor protein	Homo sapiens	171-177
32157572-4	2021	The proposed binding model of 8 and c-Met unraveled that two canonical hydrogen bonds and a pi-pi stacking interaction formed between the inhibitor and the ATP binding site of c-Met kinase domain, which accounted for its potent c-Met activities.	Hydrogen	71-79	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	36-41
32157572-4	2021	The proposed binding model of 8 and c-Met unraveled that two canonical hydrogen bonds and a pi-pi stacking interaction formed between the inhibitor and the ATP binding site of c-Met kinase domain, which accounted for its potent c-Met activities.	Hydrogen	71-79	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	176-181
32157572-4	2021	The proposed binding model of 8 and c-Met unraveled that two canonical hydrogen bonds and a pi-pi stacking interaction formed between the inhibitor and the ATP binding site of c-Met kinase domain, which accounted for its potent c-Met activities.	Hydrogen	71-79	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	176-181
33636265-2	2021	The attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) analysis show that both biomacromolecules are well organised due to the hydrogen bond interaction between molecular chains involving the hydroxyl, carbonyl, and acetyl groups.	Hydrogen	155-163	ATR serine/threonine kinase	Homo sapiens	73-76
33931646-4	2021	We analyze the currents in two experimentally synthesized gold-based, hydrogen-containing ligand-stabilized nanoclusters [HAu9(PPh3)8]2+ and [PtHAu8(PPh3)8]+.	Hydrogen	70-78	caveolin 1	Homo sapiens	149-153
33931646-7	2021	This is manifested by a stronger shielding of the hydrogen proton in the metal core of the cluster as compared to [HAu9(PPh3)8]2+, causing a significant upfield shift in agreement with experimental proton NMR data measured for these two clusters.	Hydrogen	50-58	caveolin 1	Homo sapiens	120-124
33739090-5	2021	The interaction networks of GDP and GTP with K-Ras are identified and the results uncover that the instability in hydrogen-bonding interactions of SW1 with GDP and GTP is mostly responsible for conformational disorder of SW1 and SW2 as well as tunes the activity of oncogenic K-Ras.	Hydrogen	114-122	WD repeat domain 82 pseudogene 1	Homo sapiens	229-232
33908064-6	2021	Moreover, the linear free energy relationship (LFER) analysis suggested that the solute volume, hydrogen bond basicity and J- were the main descriptors that drove the partition process of solutes in the SPC/Chol or DSPC/Chol LEKC system.	Hydrogen	96-104	surfactant protein C	Homo sapiens	203-206
33754689-4	2021	When a submonolayer of Pt is deposited on the 6 nm nanocubes, the resulting Pd@a-Pd-P@PtSML core-shell catalyst can deliver a mass activity as high as 4.08 A/mgPt and 1.37 A/mgPd+Pt toward the oxygen reduction reaction at 0.9 V vs the reversible hydrogen electrode and undergoes 50 000 potential cycles with only ~9% activity loss and negligible structural deformation.	Hydrogen	246-254	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	81-85
33885077-7	2021	A discontinuity in mode evolution between 3.7-4.3 GPa was observed for a number of modes and shown to coincide with hydrogen bond rearrangement in this pressure region.	Hydrogen	116-124	glycophorin A (MNS blood group)	Homo sapiens	50-53
33899541-8	2021	Serum analysis showed that hydrogen-rich water addition resulted in more effective reductions of total-cholesterol, low-density lipoprotein-cholesterol, and apolipoprotein B levels compared with conventional treatment.	Hydrogen	27-35	apolipoprotein B	Homo sapiens	157-173
33919170-3	2021	In all six cases, beta-CD crystallizes as a pair supported by face-to-face hydrogen bonding between hydroxyl groups on C2 and C3 and their adjacent equivalents, giving rise to a truncated-cone-shaped cavity to accommodate one, two, or three adamantane derivatives.	Hydrogen	75-83	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	18-25
33925363-3	2021	Short hydrogen bonds form at the transition states of the catalytic reactions at the active site of the enzymes as they do with mechanism-based covalent inhibitors of thrombin.	Hydrogen	6-14	coagulation factor II, thrombin	Homo sapiens	167-175
33923726-6	2021	The molecular docking showed that most of the compounds bound to AChE through hydrogen bonds with residues of the catalytic triad and pi-stacking interactions between the main scaffold and the aromatic residues present in the binding pocket.	Hydrogen	78-86	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-69
33871773-7	2021	Above key sites promoted the binding of MCLR/MCLR-DBPs to PP1 through the hydrogen bonds (H2O   Adda5, Tyr134   Adda5, H2O   Arg4, Tyr134   Arg4, Glu275   Arg4), ionic bonds (Asp197-Adda5, Glu275-Arg4, Asp220   Arg4), and H-pi bonds (Trp206   Adda5, Ser129   Adda5).	Hydrogen	74-82	neuropeptide Y receptor Y4	Homo sapiens	58-61
33871773-9	2021	Besides, the "integral hydrogen bonds and ionic bonds" between toxin and PP1 also had important effects on the toxin toxicity.	Hydrogen	23-31	neuropeptide Y receptor Y4	Homo sapiens	73-76
33874887-11	2021	RESULTS: The pancreatic pathological changes, plasma amylase and lipase activity, and the increase of plasma IL-1 and IL-6 levels in AP mice were significantly improved by the hydrogen-rich gases pretreatment, Meanwhile, the pancreatic GSH content increased and the pancreatic MDA content decreased.	Hydrogen	176-184	interleukin 6	Mus musculus	118-122
33092925-5	2021	The formation of hydrogen bonds between peptide E-M and the residues Gly143 and Gln189 of Mpro may play important roles in inhibiting the activity of Mpro.	Hydrogen	17-25	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	90-94
33092925-5	2021	The formation of hydrogen bonds between peptide E-M and the residues Gly143 and Gln189 of Mpro may play important roles in inhibiting the activity of Mpro.	Hydrogen	17-25	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	150-154
33858315-12	2022	Molecular docking reveals involvement of one hydrogen bond with Met793 in binding with EGFR however; it was not stable during simulation and these compounds bind to the receptor mainly via hydrophobic contacts.	Hydrogen	45-53	epidermal growth factor receptor	Homo sapiens	87-91
33784456-1	2021	We have experimentally shown by neutron diffraction significant shortening of both sp3- and sp2-hybridized C-H bonds to 1.092(2) and 1.081(1) A in a hydrogen-bonded crystal of a difluorinated compound, 4-((2,2-difluoroethoxy)methyl)pyridinium saccharinate.	Hydrogen	149-157	Sp3 transcription factor	Homo sapiens	83-86
33851772-3	2021	The reactivity of water is ascribed to its organization on the surface of the polyanionic scaffold through hydrogen bond networking involving the Co(II)-OH2 group.	Hydrogen	107-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	146-152
33784456-1	2021	We have experimentally shown by neutron diffraction significant shortening of both sp3- and sp2-hybridized C-H bonds to 1.092(2) and 1.081(1) A in a hydrogen-bonded crystal of a difluorinated compound, 4-((2,2-difluoroethoxy)methyl)pyridinium saccharinate.	Hydrogen	149-157	Sp2 transcription factor	Homo sapiens	92-95
33439102-0	2021	Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement via IL-10 and Sirt 1 signaling.	Hydrogen	0-8	heme oxygenase 1	Mus musculus	81-85
33920062-8	2021	A molecular modelling study suggests an important role of the hydrogen of 5"-uronamide as an essential hydrogen bonding donor for hA3AR activation.	Hydrogen	62-70	adenosine A3 receptor	Homo sapiens	130-135
33920062-8	2021	A molecular modelling study suggests an important role of the hydrogen of 5"-uronamide as an essential hydrogen bonding donor for hA3AR activation.	Hydrogen	103-111	adenosine A3 receptor	Homo sapiens	130-135
33880054-0	2021	Hydrogen (H2) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK Signaling Pathway.	Hydrogen	0-8	mitogen-activated protein kinase 8	Homo sapiens	89-92
33880054-3	2021	Hydrogen (H2) reportedly exhibits a diversity of effects such as anti-apoptotic, anti-inflammatory, and anti-oxidative properties via the JNK pathway.	Hydrogen	0-8	mitogen-activated protein kinase 8	Homo sapiens	138-141
33880054-11	2021	Results: Our results showed that hydrogen can inhibit inflammatory factors (ADAMTS5 and MMP13) and apoptosis factors (cleaved caspase-3, cytochrome c, and Bax) in TBHP-induced chondrocytes.	Hydrogen	33-41	matrix metallopeptidase 13	Homo sapiens	88-93
33880054-11	2021	Results: Our results showed that hydrogen can inhibit inflammatory factors (ADAMTS5 and MMP13) and apoptosis factors (cleaved caspase-3, cytochrome c, and Bax) in TBHP-induced chondrocytes.	Hydrogen	33-41	caspase 3	Homo sapiens	126-135
33880054-11	2021	Results: Our results showed that hydrogen can inhibit inflammatory factors (ADAMTS5 and MMP13) and apoptosis factors (cleaved caspase-3, cytochrome c, and Bax) in TBHP-induced chondrocytes.	Hydrogen	33-41	cytochrome c, somatic	Homo sapiens	137-149
33880054-11	2021	Results: Our results showed that hydrogen can inhibit inflammatory factors (ADAMTS5 and MMP13) and apoptosis factors (cleaved caspase-3, cytochrome c, and Bax) in TBHP-induced chondrocytes.	Hydrogen	33-41	BCL2 associated X, apoptosis regulator	Homo sapiens	155-158
33880054-13	2021	In vivo results showed that hydrogen can down-regulate the expression of p-JNK and cleaved caspase-3 expression.	Hydrogen	28-36	caspase 3	Homo sapiens	91-100
33880054-14	2021	Conclusion: We uncovered that hydrogen (H2) could alleviate apoptosis response and ECM degradation in human chondrocytes via inhibiting the activation of the JNK signaling pathway.	Hydrogen	30-38	mitogen-activated protein kinase 8	Homo sapiens	158-161
33917059-4	2021	In addition, we characterize through the hydrogen/deuterium (H/D) exchange assay the interface between Scs2 and Epo1.	Hydrogen	41-49	Epo1p	Saccharomyces cerevisiae S288C	112-116
33733764-1	2021	The nickel(II) complex [ON(H)O]Ni(PPh3) ([ON(H)O]2- = bis(3,5-di-tert-butyl-2-phenoxy)amine), bearing a protonated redox-active ligand, was examined for its ability to serve as a hydrogen atom (H ) and hydride (H-) donor.	Hydrogen	179-187	caveolin 1	Homo sapiens	34-38
33733764-2	2021	Deprotonation of [ON(H)O]Ni(PPh3) afforded the square-planar anion {[ONOcat]Ni(PPh3)}1-, whereas hydrogen atom transfer from [ON(H)O]Ni(PPh3) to TEMPO  in the presence of added PPh3 afforded five-coordinate [ONO]Ni(PPh3)2 that has been structurally characterized.	Hydrogen	97-105	caveolin 1	Homo sapiens	28-32
33733764-2	2021	Deprotonation of [ON(H)O]Ni(PPh3) afforded the square-planar anion {[ONOcat]Ni(PPh3)}1-, whereas hydrogen atom transfer from [ON(H)O]Ni(PPh3) to TEMPO  in the presence of added PPh3 afforded five-coordinate [ONO]Ni(PPh3)2 that has been structurally characterized.	Hydrogen	97-105	caveolin 1	Homo sapiens	79-83
33733764-2	2021	Deprotonation of [ON(H)O]Ni(PPh3) afforded the square-planar anion {[ONOcat]Ni(PPh3)}1-, whereas hydrogen atom transfer from [ON(H)O]Ni(PPh3) to TEMPO  in the presence of added PPh3 afforded five-coordinate [ONO]Ni(PPh3)2 that has been structurally characterized.	Hydrogen	97-105	caveolin 1	Homo sapiens	79-83
33733764-2	2021	Deprotonation of [ON(H)O]Ni(PPh3) afforded the square-planar anion {[ONOcat]Ni(PPh3)}1-, whereas hydrogen atom transfer from [ON(H)O]Ni(PPh3) to TEMPO  in the presence of added PPh3 afforded five-coordinate [ONO]Ni(PPh3)2 that has been structurally characterized.	Hydrogen	97-105	caveolin 1	Homo sapiens	79-83
33733764-2	2021	Deprotonation of [ON(H)O]Ni(PPh3) afforded the square-planar anion {[ONOcat]Ni(PPh3)}1-, whereas hydrogen atom transfer from [ON(H)O]Ni(PPh3) to TEMPO  in the presence of added PPh3 afforded five-coordinate [ONO]Ni(PPh3)2 that has been structurally characterized.	Hydrogen	97-105	caveolin 1	Homo sapiens	79-83
33851030-6	2021	Further molecular docking simulations showed that two compounds made strong hydrogen bond interaction with different KIT mutant proteins.	Hydrogen	76-84	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	117-120
33439102-8	2021	Molecular hydrogen inhibits the lipopolysaccharide-induced production of inflammation cytokines through an HO-1/IL-10-independent pathway.	Hydrogen	10-18	heme oxygenase 1	Mus musculus	107-111
33439102-8	2021	Molecular hydrogen inhibits the lipopolysaccharide-induced production of inflammation cytokines through an HO-1/IL-10-independent pathway.	Hydrogen	10-18	interleukin 10	Mus musculus	112-117
33439102-10	2021	Sirt1 induction by molecular hydrogen via the HO-1/AMPK/PPARalpha/PPARgamma pathway suppresses palmitate-mediated abnormal fat metabolism.	Hydrogen	29-37	heme oxygenase 1	Mus musculus	46-50
33439102-10	2021	Sirt1 induction by molecular hydrogen via the HO-1/AMPK/PPARalpha/PPARgamma pathway suppresses palmitate-mediated abnormal fat metabolism.	Hydrogen	29-37	peroxisome proliferator activated receptor alpha	Mus musculus	56-65
33928085-11	2021	Finally, we demonstrated the direct interaction between DOX and TLR2 via hydrogen bonds on Pro-681 and Glu-727 and Pro-681 and Ser-704 may be the key residues by which LCZ696 affects the interaction between DOX and TLR2.	Hydrogen	73-81	toll-like receptor 2	Rattus norvegicus	64-68
33515602-8	2021	We used Attenuated Total Reflection Spectroscopy (ATR) in the Terahertz frequency range to characterize the changes in the hydrogen bonding network accompanying the FUS enrichment in liquid-liquid phase-separated droplets to provide experimental evidence for the key role of the solvent as a thermodynamic driving force.	Hydrogen	123-131	FUS RNA binding protein	Homo sapiens	165-168
33439102-0	2021	Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement via IL-10 and Sirt 1 signaling.	Hydrogen	0-8	interleukin 10	Mus musculus	102-107
33551154-5	2021	In the placenta, HS treatment also increased the expression of the HSPA1A gene.	Hydrogen	17-19	heat shock protein 70.1	Capra hircus	67-73
32930954-0	2021	1H, 13C and 15N resonance assignment of the YTH domain of YTHDC2.	Hydrogen	0-2	YTH domain containing 2	Homo sapiens	58-64
32930954-5	2021	Here, we report 1H, 13C and 15N resonance assignment of YTH2 and its solution structure to examine the difference of the structural architecture and the dynamic properties of YTH1 and YTH2.	Hydrogen	16-18	YTH domain containing 2	Homo sapiens	56-60
32936430-2	2021	Here we report a complete set of 1H, 13C, 15N backbone and side chain resonance assignments for the p50 DNA binding and dimerization domains of the p50 homodimer form of the NF-kappaB transcription factor.	Hydrogen	33-35	nuclear factor kappa B subunit 1	Homo sapiens	100-103
32936430-2	2021	Here we report a complete set of 1H, 13C, 15N backbone and side chain resonance assignments for the p50 DNA binding and dimerization domains of the p50 homodimer form of the NF-kappaB transcription factor.	Hydrogen	33-35	nuclear factor kappa B subunit 1	Homo sapiens	148-151
32936430-2	2021	Here we report a complete set of 1H, 13C, 15N backbone and side chain resonance assignments for the p50 DNA binding and dimerization domains of the p50 homodimer form of the NF-kappaB transcription factor.	Hydrogen	33-35	nuclear factor kappa B subunit 1	Homo sapiens	174-183
33063293-2	2021	Here, we report on neurometabolic alterations in spinocerebellar ataxia type 1 (SCA1; SCA-ATXN1) and 14 (SCA14; SCA-PRKCG) assessed by non-invasive 1H magnetic resonance spectroscopy.	Hydrogen	148-150	ataxin 1	Homo sapiens	49-78
33063293-2	2021	Here, we report on neurometabolic alterations in spinocerebellar ataxia type 1 (SCA1; SCA-ATXN1) and 14 (SCA14; SCA-PRKCG) assessed by non-invasive 1H magnetic resonance spectroscopy.	Hydrogen	148-150	ataxin 1	Homo sapiens	80-84
33063293-13	2021	1H magnetic resonance spectroscopy revealed differing neurochemical profiles in SCA1 and SCA14 and confirmed metabolic changes that may be indicative for neuronal loss and dysfunctional energy metabolism.	Hydrogen	0-2	ataxin 1	Homo sapiens	80-84
33185132-3	2021	The phenyl ring of TT was inserted into the secondary hydroxy face of SBE-beta-CD, as demonstrated by 1H-1H rotating frame nuclear Overhauser effect spectroscopy NMR.	Hydrogen	102-104	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	74-81
33185132-3	2021	The phenyl ring of TT was inserted into the secondary hydroxy face of SBE-beta-CD, as demonstrated by 1H-1H rotating frame nuclear Overhauser effect spectroscopy NMR.	Hydrogen	105-107	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	74-81
33500067-0	2021	Using Palladium Nanocubes on ZnO Nanostructures in Hydrogen Gas Sensor for Fast Response and Recovery Time.	Hydrogen	51-59	Fas activated serine/threonine kinase	Homo sapiens	75-79
33630249-7	2021	Structural analysis demonstrated that the intermolecular binding between LC8 and VP35 is mainly sustained by a network of hydrogen bonds and supported by hydrophobic interactions in which Thr73 and Thr75 of VP35 are involved.	Hydrogen	122-130	dynein light chain LC8-type 1	Homo sapiens	73-76
33849696-4	2021	Molecular docking results showed that compound 11c occupied a unique subpocket and formed a hydrogen bond with Glu1138 of TNKS2, which was not consistent with the patterns of known TNKS inhibitors and thus warrants further research.	Hydrogen	92-100	tankyrase	Homo sapiens	122-126
33332667-1	2021	The results of the quantum-chemical investigation of a series of hydrogen-bonded 1:1 acid-base complexes formed by model phosphinic acids, Me2 POOH and PhHPOOH, are reported.	Hydrogen	65-73	malic enzyme 2	Homo sapiens	139-142
33717270-3	2021	It has been well established that the regulation of intra- and extracellular pH depends on a series of functional ion transporters and hydrogen ion channels, such as the Na+/H+ exchanger (NHE) protein and thee Cl/HCO3- exchange protein, among which the NHE1 member of the NHE family has been attracting increasing attention in recent years, particularly in studies on the correlation between pH regulation and tumors.	Hydrogen	135-143	solute carrier family 9 member A1	Homo sapiens	253-257
32178584-6	2021	The analysis of the binding modes of G1 and G10 provides a reference for further development of highly active HDAC6 inhibitors.Abbreviations: DS: Discovery Studio; HBA: hydrogen bond acceptor; HBD: hydrogen bond donor, H: hydrophobic; PAINS: Pan Assay Interference Compounds; R: ring-aromatic; RMSD: Root-mean-square deviation.	Hydrogen	169-177	histone deacetylase 6	Homo sapiens	110-115
32178584-6	2021	The analysis of the binding modes of G1 and G10 provides a reference for further development of highly active HDAC6 inhibitors.Abbreviations: DS: Discovery Studio; HBA: hydrogen bond acceptor; HBD: hydrogen bond donor, H: hydrophobic; PAINS: Pan Assay Interference Compounds; R: ring-aromatic; RMSD: Root-mean-square deviation.	Hydrogen	198-206	histone deacetylase 6	Homo sapiens	110-115
33786727-8	2022	A number of bonding interactions in terms of hydrogen bond and hydrophobic interactions were observed between the proposed molecules and ligand-interacting amino acids of the TMPRSS2.	Hydrogen	45-53	transmembrane serine protease 2	Homo sapiens	175-182
33876098-7	2021	In addition, the RDG scatter graphs predict large negative values of rho*, which indicate that the hydrogen bonding network in AAT is stronger, enhancing the delocalization of the electron density.	Hydrogen	99-107	serpin family A member 1	Homo sapiens	127-130
33438792-2	2021	Inspired by the interesting Z-scheme process, here we demonstrated a photocatalytic hydrogen evolution reaction (HER) employing chlorophyll derivatives, Chl-1 and Chl-2, on the surface of Ti3C2Tx MXenes with two-dimensional accordion-like morphology forming Chl-1@Chl-2@Ti3C2Tx composite.	Hydrogen	84-92	cell adhesion molecule L1 like	Homo sapiens	153-158
33300177-5	2021	The unique association behavior is due to the presence of sp 2 -hybridized nitrogen atoms, which weakly coordinate to the hydrogen atoms of these solvents and reduce the  pi -electron density of the circulene cores.	Hydrogen	122-130	Sp2 transcription factor	Homo sapiens	58-62
33758209-7	2021	An in silico study further demonstrated that ETD binds to the protein kinase domain of Akt with both hydrogen bonding and van der Waals interactions.	Hydrogen	101-109	AKT serine/threonine kinase 1	Homo sapiens	87-90
33648337-4	2021	1H NMR experiments performed in 30% CaCl2/D2O at 273 K along with molecular dynamics simulations allowed us to identify two arrangements of the guest@beta-CD complexes.	Hydrogen	0-2	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	150-157
33656848-6	2021	This mechanically induced structural transformation coincided with the dissociative surface reaction between hydrogen (oxygen) gas molecules and sp2 carbon-carbon bonds that are highly strained, which results in the formation of carbon-hydrogen groups (carbonyl or ether groups together with silicon atoms having higher oxidation states).	Hydrogen	236-244	Sp2 transcription factor	Homo sapiens	145-148
33608073-3	2021	While in the presence of Pb(II), the G-quadruplex structure originating from two G-quartet planes by the intramolecular hydrogen bond with Pb(II) also causes the HEX approaching the (G)4 terminal and consequently the fluorescence quenching.	Hydrogen	120-128	submaxillary gland androgen regulated protein 3B	Homo sapiens	25-31
33608073-3	2021	While in the presence of Pb(II), the G-quadruplex structure originating from two G-quartet planes by the intramolecular hydrogen bond with Pb(II) also causes the HEX approaching the (G)4 terminal and consequently the fluorescence quenching.	Hydrogen	120-128	submaxillary gland androgen regulated protein 3B	Homo sapiens	139-145
33711090-12	2021	The N3 inhibitor has more favourable non-covalent interactions, particularly hydrogen bonding, in the binding site of the Mpro than the alpha-ketoamide inhibitor.	Hydrogen	77-85	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	122-126
33438792-2	2021	Inspired by the interesting Z-scheme process, here we demonstrated a photocatalytic hydrogen evolution reaction (HER) employing chlorophyll derivatives, Chl-1 and Chl-2, on the surface of Ti3C2Tx MXenes with two-dimensional accordion-like morphology forming Chl-1@Chl-2@Ti3C2Tx composite.	Hydrogen	84-92	cell adhesion molecule L1 like	Homo sapiens	258-263
33711010-9	2021	Differences in the morphology and dynamics of aggregates that comprise SST14 or AVP appear to reflect distinct (1) regions of the Abeta chains they interact with; (2) the propensities to engage in hydrogen bonds with Abeta peptides; and (3) solvent exposures of hydrophilic and hydrophobic groups.	Hydrogen	197-205	amyloid beta precursor protein	Homo sapiens	217-222
33548803-3	2021	We elucidated crucial roles of the methylsulfonyl group of 2 in its interaction with the hERG channel and the GPR119 receptor, presumably as a hydrogen bond acceptor (HBA).	Hydrogen	143-151	ETS transcription factor ERG	Homo sapiens	89-93
33284506-3	2021	Quantitative conversion of HMF to DMF was achieved in the presence of formic acid (FA) and H 2 over Pd/NMC within 2 h. The reaction mechanism, especially the multiple roles of FA, was explored through a detailed comparative study by varying hydrogen source, additive, and substrate as well as by applying in situ ATR-IR spectroscopy.	Hydrogen	241-249	ATR serine/threonine kinase	Homo sapiens	313-316
33162129-6	2021	This study provided an alternative method to enhanced hydrogen production and a better understanding of the mechanism of L-cysteine action in MEC performance.	Hydrogen	54-62	C-C motif chemokine ligand 28	Homo sapiens	142-145
33707497-1	2021	Parahydrogen-induced polarization of 13C nuclei by side-arm hydrogenation (PHIP-SAH) for [1-13C]acetate and [1-13C]pyruvate esters with application of PH-INEPT-type pulse sequences for 1H to 13C polarization transfer is reported, and its efficiency is compared with that of polarization transfer based on magnetic field cycling (MFC).	Hydrogen	185-187	pleckstrin homology domain interacting protein	Homo sapiens	75-79
33732014-10	2021	Results: The results illustrated that hydrogen-rich water could alleviate oxaliplatin-induced hyperalgesia, reduce the microbial diversity and alter the structure of gut microbiota, reverse the imbalance of inflammatory cytokines and oxidative stress, and decrease the expression of LPS and TLR4.	Hydrogen	38-46	toll-like receptor 4	Mus musculus	291-295
33625838-6	2021	Upon introduction of CO2 or C2H2 into desolvated MFM-160a, this rate of rotation was found to increase with increasing gas pressure, a phenomenon attributed to the weakening of an intramolecular hydrogen bond in the triazine-containing linker upon gas binding.	Hydrogen	195-203	PAXIP1 associated glutamate rich protein 1	Homo sapiens	119-122
33625838-6	2021	Upon introduction of CO2 or C2H2 into desolvated MFM-160a, this rate of rotation was found to increase with increasing gas pressure, a phenomenon attributed to the weakening of an intramolecular hydrogen bond in the triazine-containing linker upon gas binding.	Hydrogen	195-203	PAXIP1 associated glutamate rich protein 1	Homo sapiens	248-251
33732014-11	2021	Conclusion: Hydrogen-rich water may alleviate CINP by affecting the diversity and structure of the gut microbiota, and then the LPS-TLR4 pathway, which provides a direction for further research.	Hydrogen	12-20	toll-like receptor 4	Mus musculus	132-136
33683726-5	2021	Molecular docking studies suggested that 13q exhibited critical hydrogen-bond interactions with the critical amino acid residues Lys29, Lys31, Asn111, and Asp88 at the binding site of the AMPK protein.	Hydrogen	64-72	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	188-192
33358270-7	2021	The molecular docking confirms that the compound 18 activated caspase-3 via the formation of hydrogen bonds and hydrophobic interactions.	Hydrogen	93-101	caspase 3	Homo sapiens	62-71
33310611-7	2021	Through the topological analysis and the Independent Gradient Model (IGM) analysis, the O-H...O hydrogen bond in beta-CD-D-Pen is stronger than that in beta-CD-L-Pen, and the van der Waals interactions such as C-H...O,C-H...N,C-H...S, O...S and C-H...C-H have the most contributions to the intermolecular interaction in beta-CD-D/L-Pen.	Hydrogen	96-104	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	113-120
33586436-0	2021	Hydrogen-Bond Acceptance of Solvents: A 19F Solvatomagnetic beta1 Database to Replace Solvatochromic and Solvatovibrational Scales.	Hydrogen	0-8	BCL2 related protein A1	Homo sapiens	60-65
33586436-6	2021	The results for about 240 hydrogen-bond acceptor solvents are organized in a numerical beta1 database.	Hydrogen	26-34	BCL2 related protein A1	Homo sapiens	87-92
33571414-3	2021	We performed molecular docking calculations, which revealed that GA fits well into the five subpockets of the Kelch-like ECH-associated protein1 (Keap1) Kelch domain via hydrogen bonding and hydrophobic interaction.	Hydrogen	170-178	kelch like ECH associated protein 1	Homo sapiens	110-144
33571414-3	2021	We performed molecular docking calculations, which revealed that GA fits well into the five subpockets of the Kelch-like ECH-associated protein1 (Keap1) Kelch domain via hydrogen bonding and hydrophobic interaction.	Hydrogen	170-178	kelch like ECH associated protein 1	Homo sapiens	146-151
33648410-3	2021	The pharmacophore model for FFAR-1 (r2 = 0.98, q2 = 0.90) and PPAR-G (r2 = 0.89, q2 = 0.88) suggested that one hydrogen bond acceptor, one hydrogen bond donor, three aromatic rings, and two hydrophobic groups arranged in 3D space are essential for the binding affinity of FFAR-1 and PPAR-G inhibitors.	Hydrogen	111-119	peroxisome proliferator activated receptor gamma	Homo sapiens	62-68
33648410-3	2021	The pharmacophore model for FFAR-1 (r2 = 0.98, q2 = 0.90) and PPAR-G (r2 = 0.89, q2 = 0.88) suggested that one hydrogen bond acceptor, one hydrogen bond donor, three aromatic rings, and two hydrophobic groups arranged in 3D space are essential for the binding affinity of FFAR-1 and PPAR-G inhibitors.	Hydrogen	111-119	peroxisome proliferator activated receptor gamma	Homo sapiens	283-289
33648410-3	2021	The pharmacophore model for FFAR-1 (r2 = 0.98, q2 = 0.90) and PPAR-G (r2 = 0.89, q2 = 0.88) suggested that one hydrogen bond acceptor, one hydrogen bond donor, three aromatic rings, and two hydrophobic groups arranged in 3D space are essential for the binding affinity of FFAR-1 and PPAR-G inhibitors.	Hydrogen	139-147	peroxisome proliferator activated receptor gamma	Homo sapiens	62-68
33648410-3	2021	The pharmacophore model for FFAR-1 (r2 = 0.98, q2 = 0.90) and PPAR-G (r2 = 0.89, q2 = 0.88) suggested that one hydrogen bond acceptor, one hydrogen bond donor, three aromatic rings, and two hydrophobic groups arranged in 3D space are essential for the binding affinity of FFAR-1 and PPAR-G inhibitors.	Hydrogen	139-147	peroxisome proliferator activated receptor gamma	Homo sapiens	283-289
33661069-5	2021	In addition, the H-O radial distribution functions (RDFs) were computed to assess the stability of hydrogen bonding interactions between inhibitors and CBP, and the obtained information identifies several key hydrogen bonds playing key roles in bindings of E3T, E3H and E3B to CBP.	Hydrogen	99-107	CREB binding protein	Homo sapiens	152-155
33520682-9	2021	Out of these four proteins, Mpro exhibited the strongest binding affinity with the least binding energy (-8.9 kcal/mol) and stabilized through hydrogen bonds with bond lengths ranging from 1.18 A to 3.17 A as well as hydrophobic interactions.	Hydrogen	143-151	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	28-32
33359132-9	2021	Thermodynamics parameters revealed involvement of hydrogen bonding and van der Waals forces for HSA-DHP binding.	Hydrogen	50-58	dihydropyrimidinase	Homo sapiens	100-103
31239533-6	2021	Chronic alcohol drinking results in a significant increased methylation of the NR3C1 exon variant 1H, with a particular increase in the levels of 5-hydroxymethylcytosine over 5-methylcytosine.	Hydrogen	98-100	nuclear receptor subfamily 3 group C member 1	Homo sapiens	79-84
33661069-5	2021	In addition, the H-O radial distribution functions (RDFs) were computed to assess the stability of hydrogen bonding interactions between inhibitors and CBP, and the obtained information identifies several key hydrogen bonds playing key roles in bindings of E3T, E3H and E3B to CBP.	Hydrogen	99-107	CREB binding protein	Homo sapiens	277-280
33661069-5	2021	In addition, the H-O radial distribution functions (RDFs) were computed to assess the stability of hydrogen bonding interactions between inhibitors and CBP, and the obtained information identifies several key hydrogen bonds playing key roles in bindings of E3T, E3H and E3B to CBP.	Hydrogen	209-217	CREB binding protein	Homo sapiens	152-155
33661069-5	2021	In addition, the H-O radial distribution functions (RDFs) were computed to assess the stability of hydrogen bonding interactions between inhibitors and CBP, and the obtained information identifies several key hydrogen bonds playing key roles in bindings of E3T, E3H and E3B to CBP.	Hydrogen	209-217	CREB binding protein	Homo sapiens	277-280
33620127-4	2021	The WPD-loop closure of PTPN18 relates directly to the new hydrogen bond and hydrophobic interaction formations between the residues Tyr62, Asp64, Val65, Ala231, Arg235, and Ala273 in PTPN18 and Tyr(PO3) in the HER2 phospho-peptides, which suggests that these key residues would contribute to the specific regulation of PTPN18 to the substrates.	Hydrogen	59-67	protein tyrosine phosphatase non-receptor type 18	Homo sapiens	24-30
33555182-5	2021	Here we show that the dimer interfacial residues control the stabilization of the global hydrogen bond network of the NF-kappaB dimerization domain, which, in turn, controls the thermodynamic stabilization of different NF-kappaB dimers.	Hydrogen	89-97	nuclear factor kappa B subunit 1	Homo sapiens	118-127
33555182-5	2021	Here we show that the dimer interfacial residues control the stabilization of the global hydrogen bond network of the NF-kappaB dimerization domain, which, in turn, controls the thermodynamic stabilization of different NF-kappaB dimers.	Hydrogen	89-97	nuclear factor kappa B subunit 1	Homo sapiens	219-228
33620127-4	2021	The WPD-loop closure of PTPN18 relates directly to the new hydrogen bond and hydrophobic interaction formations between the residues Tyr62, Asp64, Val65, Ala231, Arg235, and Ala273 in PTPN18 and Tyr(PO3) in the HER2 phospho-peptides, which suggests that these key residues would contribute to the specific regulation of PTPN18 to the substrates.	Hydrogen	59-67	protein tyrosine phosphatase non-receptor type 18	Homo sapiens	184-190
33620127-4	2021	The WPD-loop closure of PTPN18 relates directly to the new hydrogen bond and hydrophobic interaction formations between the residues Tyr62, Asp64, Val65, Ala231, Arg235, and Ala273 in PTPN18 and Tyr(PO3) in the HER2 phospho-peptides, which suggests that these key residues would contribute to the specific regulation of PTPN18 to the substrates.	Hydrogen	59-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	211-215
33620127-4	2021	The WPD-loop closure of PTPN18 relates directly to the new hydrogen bond and hydrophobic interaction formations between the residues Tyr62, Asp64, Val65, Ala231, Arg235, and Ala273 in PTPN18 and Tyr(PO3) in the HER2 phospho-peptides, which suggests that these key residues would contribute to the specific regulation of PTPN18 to the substrates.	Hydrogen	59-67	protein tyrosine phosphatase non-receptor type 18	Homo sapiens	184-190
33545005-6	2021	In comparison, V13 bears a less symmetrical structure and reacts readily with water, allowing for recombination of a hydroxyl atom with an adsorbed hydrogen atom, akin to a fishing-mode HER process.	Hydrogen	148-156	immunoglobulin lambda variable 2-11	Homo sapiens	15-18
33534993-7	2021	These results suggest that the Lewis acid and nucleophile activations provided by the Zn metal center of NEP are more effective than the hydrogen bonding interactions afforded by the catalytic Ser85-His180-Asp165 triad of CLE.	Hydrogen	137-145	membrane metalloendopeptidase	Homo sapiens	105-108
33534993-7	2021	These results suggest that the Lewis acid and nucleophile activations provided by the Zn metal center of NEP are more effective than the hydrogen bonding interactions afforded by the catalytic Ser85-His180-Asp165 triad of CLE.	Hydrogen	137-145	eukaryotic translation initiation factor 2B subunit epsilon	Homo sapiens	222-225
33514951-2	2021	Characterization of Tl2(OCtBu2Ph)2 by 1H and 13C NMR spectroscopy and X-ray crystallography reveals the presence of two isomers differing by the mutual conformation of the alkoxide ligands, and by the planarity of the central Tl-O-Tl-O plane.	Hydrogen	38-40	TNF superfamily member 10	Homo sapiens	20-23
33565536-1	2021	To overcome the shuttle effect in lithium-sulfur (Li-S) batteries, an sp/sp2 hybridized all-carbon interlayer by coating graphene (Gra) and hydrogen-substituted graphdiyne (HsGDY) with a specific surface area as high as 2184 m2 g-1 on a cathode is designed and prepared.	Hydrogen	140-148	Sp2 transcription factor	Homo sapiens	73-76
33477020-7	2021	RESULTS: The docking results showed that the synthesized compounds were able to form hydrogen bonds with COX-2 involving methyl sulfonyl, spiroisoxazoline, meta-methoxy and fluoro functional groups.	Hydrogen	85-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
33440318-6	2021	Molecular modeling studies corroborated the in vitro inhibitory mode of interaction and show that compound 10c is stabilized into hBuChE by strong hydrogen bond interaction with Tyr128, pi-pi stacking interaction with Trp82 and CH O interactions with His438, Gly121 and Glu197.	Hydrogen	147-155	Rho GTPase activating protein 9	Homo sapiens	107-110
32919374-6	2021	Our findings suggested that the inhibitors were allosterically bound to the active center of mPPO through hydrogen bonds and ion contacts.	Hydrogen	106-114	protoporphyrinogen oxidase	Mus musculus	93-97
33583373-6	2021	Structure-activity relationship of xanthones revealed that the type and position of substituent(s) attached to the xanthone moiety influenced their acetylcholinesterase inhibition activities where hydrophobic moiety will lead to an improved activity by contributing the pi-pi interactions, as well as the hydroxy substituent(s) by forming hydrogen-bond interactions.	Hydrogen	339-347	acetylcholinesterase (Cartwright blood group)	Homo sapiens	148-168
33672042-4	2021	The calculated thermodynamic parameters revealed that the binding of pesticides into serum albumin macromolecules mainly depended on hydrogen bonds and van der Waals interactions.	Hydrogen	133-141	albumin	Homo sapiens	91-98
33472367-10	2021	Additionally, thermodynamic analysis and free energy calculations shed light on the role of a structural water molecule that synergistically binds to YTHDC1 with m6A and acts as the hub of a hydrogen-bond network.	Hydrogen	191-199	YTH domain containing 1	Homo sapiens	150-156
33507752-2	2021	Specifically, the presence of chemisorbed hydrogen atoms forming an sp3-hybridized C-H bond is known to increase the reactivity of neighboring carbon atoms toward additional hydrogenation with wide-ranging applications from materials science to astrochemistry.	Hydrogen	42-50	Sp3 transcription factor	Homo sapiens	68-71
33502401-6	2021	Furthermore, the number of hydrogen bonds in each tetrad and the distance between the two central K+ cations confirm that the c-KIT G-quadruplex DNA maintains its conformation in the process of complex formation with the APTO-253 ligand.	Hydrogen	27-35	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	126-131
33270337-3	2021	We extended this strategy to prepare Hf12 -Ru-Co-OTf MOL with a [Ru(DBB)(bpy)2 ]2+ photosensitizer and Hf12 SBU capped with triflate as strong Lewis acids and PPA-Co as a hydrogen transfer catalyst.	Hydrogen	171-179	zinc finger protein 3	Homo sapiens	37-41
33563198-8	2021	Six hydrogen bonds along with hydrophobic interaction were detected on the complex of BCL-XL with muricin B (2), muricin G (5), corossolone (11) and isoannonacin-10-one A (18).	Hydrogen	4-12	BCL2 like 1	Homo sapiens	86-92
33017787-5	2021	van der Waals force and hydrogen bond were involved in the HSA-NRB interaction as per the results of thermodynamic parameters.	Hydrogen	24-32	albumin	Homo sapiens	59-62
33038856-0	2021	A fluorescence approach on the investigation of urea derivatives interaction with a non-PET based acridinedione dye-beta Cyclodextrin (beta-CD) complex in water: Hydrogen-bonding interaction or hydrophobic influences or combined effect?	Hydrogen	162-170	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	135-142
33038856-4	2021	The formation of urea-water hydrogen-bonding self assemblies and creation of microspheres of varying environment results in an effective displacement of dye from the hydrophobic nanocavity of beta-CD.	Hydrogen	28-36	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	192-199
33038856-6	2021	The nature of urea derivative, hydrogen-bonding of urea-water assemblies and hydrophobic influences of methyl moieties in urea molecular framework governs the stability and also the dissociation of dye-beta-CD complex.	Hydrogen	31-39	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	202-209
33472361-4	2021	Increasing pH and/or decreasing oxygen promoted the conversion of nitrate (NO3-) into NO2- but suppressed the H2O2 formation, suggesting that there was a transition of radicals from oxidizing species like hydroxyl radicals to reducing species like hydrogen atoms and hydrated electrons.	Hydrogen	248-256	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
33465671-9	2021	The molecular docking study suggested that the complex 1 formed a hydrogen bond with amino acid R120 in the active site of the Human cyclooxygenase-2 (COX-2).	Hydrogen	66-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	133-149
33332093-7	2021	Furthermore, MEF could induce the abnormal expression of CYP3A65, GSTM1, p53, and DNMT1 genes in the liver due to the formation of hydrogen bonds between MEF and the protein residues of those genes.	Hydrogen	131-139	DNA (cytosine-5-)-methyltransferase 1	Danio rerio	82-87
32975902-0	2021	OCRE Domains of Splicing Factors RBM5 and RBM10: Tyrosine Ring Flip Frequencies by Integrated Use of 1H-NMR and Molecular Dynamics Simulations.	Hydrogen	101-103	RNA binding motif protein 5	Homo sapiens	33-37
33552834-4	2021	Our comprehensive structure analysis revealed that the natural substitution of amino acid residues Gln24, His34, Phe40, Leu79 and Met82 in the N-terminal alpha1 and alpha2 helices of the ACE2 receptor results in loss of crucial network of hydrogen-bonded and hydrophobic interactions with receptor binding domain of SARS-CoV-2 spike protein.	Hydrogen	239-247	BCL2 related protein A1	Homo sapiens	154-171
33465671-9	2021	The molecular docking study suggested that the complex 1 formed a hydrogen bond with amino acid R120 in the active site of the Human cyclooxygenase-2 (COX-2).	Hydrogen	66-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	151-156
33576707-8	2021	Moreover, FT-IR and 1H NMR results indicate the formation of true inclusion complex between DTX and DM-beta-CD at 1:1 molar ratio.	Hydrogen	20-22	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	103-110
33526773-4	2021	We envision that the hydrogen elimination from sp2-carbon is possible by using thoroughly designed reaction systems, which may offer a new strategy for the preparation of allenes.	Hydrogen	21-29	Sp2 transcription factor	Homo sapiens	47-50
33347930-10	2021	Insights obtained from molecular docking suggested that Carmine interaction with monomeric GDC6 involved hydrogen bonding with Ace group, Cys, Met residues and hydrophobic contact with Trp residue.	Hydrogen	105-113	angiotensin I converting enzyme	Homo sapiens	127-130
31916505-7	2021	It is shown from the molecular dynamics simulations results of the top-ranked ligands that increased numbers of hydrogen bonds are formed with PPAR-gamma catalytic residues.	Hydrogen	112-120	peroxisome proliferator activated receptor gamma	Homo sapiens	143-153
33323309-9	2021	Modelling of the mutant KCC3 cotransporter showed altered formation of hydrogen bonds and weakened interaction force between the mutated site and its surrounding amino acid residues.	Hydrogen	71-79	solute carrier family 12 member 6	Homo sapiens	24-28
33387885-6	2021	Therefore, it was observed that, regarding the interactions of chalcones with Main protease (Mpro), the chalcone N-(4"[(2E)-3-(4-flurophenyl)-1-(phenyl)prop-2-en-1-one]) acetamide (PAAPF) has the potential for coupling in the same region as the natural inhibitor FJC through strong hydrogen bonding.	Hydrogen	282-290	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	93-97
33514547-4	2021	Results suggest that C-type inactivation in hERG is associated with an asymmetrical constricted-like conformation of the selectivity filter, identifying F627 side-chain rotation and the hydrogen bond between Y616 and N629 as key determinants.	Hydrogen	186-194	ETS transcription factor ERG	Homo sapiens	44-48
33449065-0	2021	First-principles investigation of the hydrogen evolution reaction of transition metal phosphides CrP, MnP, FeP, CoP, and NiP.	Hydrogen	38-46	C-reactive protein	Homo sapiens	97-100
33449683-0	2021	SRLS Analysis of 15N-1H NMR Relaxation from the Protein S100A1: Dynamic Structure, Calcium Binding, and Related Changes in Conformational Entropy.	Hydrogen	21-23	S100 calcium binding protein A1	Homo sapiens	56-62
33352228-10	2021	CA interacted with Arg78 of tumor necrosis factor receptor-associated factor 6 (TRAF6) by hydrogen bonding.	Hydrogen	90-98	TNF receptor-associated factor 6	Mus musculus	28-78
33352228-10	2021	CA interacted with Arg78 of tumor necrosis factor receptor-associated factor 6 (TRAF6) by hydrogen bonding.	Hydrogen	90-98	TNF receptor-associated factor 6	Mus musculus	80-85
33422953-14	2021	Molecular docking results predicted high affinity interaction between PQ-A and NF-kappaB/p65, involving hydrogen-bond interactions at five amino acid residues, suggesting NF-kappaB/p65 as a target.	Hydrogen	104-112	synaptotagmin 1	Rattus norvegicus	89-92
32881084-9	2021	An interplay of electrostatic, hydrophobic, hydrogen bonding and aromatic stacking interactions facilitates the formation of the hIL-6/IL-6Ralpha complex.	Hydrogen	44-52	interleukin 6	Homo sapiens	129-134
32881084-9	2021	An interplay of electrostatic, hydrophobic, hydrogen bonding and aromatic stacking interactions facilitates the formation of the hIL-6/IL-6Ralpha complex.	Hydrogen	44-52	interleukin 6 receptor	Homo sapiens	135-145
33384112-0	2021	Design of ratiometric monoaromatic fluorescence probe via modulating intramolecular hydrogen bonding: A case study of alkaline phosphatase sensing.	Hydrogen	84-92	alkaline phosphatase, placental	Homo sapiens	118-138
33320652-12	2021	Interaction analysis reveals that hydrophobic and hydrogen-bonding interactions are the primary driving forces responsible for the observed high affinity of the compound with AChE.	Hydrogen	50-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	175-179
33495506-8	2021	Furthermore, to test the exact role of both the cognate receptors of C5a (C5aR1 and C5aR2), experimental PT + HS was induced in C5aR1 knockout (C5aR1 KO) and C5aR2 KO mice.	Hydrogen	110-112	complement component 5a receptor 1	Mus musculus	128-133
33495506-8	2021	Furthermore, to test the exact role of both the cognate receptors of C5a (C5aR1 and C5aR2), experimental PT + HS was induced in C5aR1 knockout (C5aR1 KO) and C5aR2 KO mice.	Hydrogen	110-112	complement component 5a receptor 1	Mus musculus	128-133
33189437-4	2021	The binding hypothesis revealed different pockets, grooves and a central cavity where ligand-receptor interaction with specific residues through hydrophobic and hydrogen bond interactions take place, which correlate with TLR7 antagonistic activity thus paving the way for rational design using varied chemotypes.	Hydrogen	161-169	toll like receptor 7	Homo sapiens	221-225
33603945-0	2021	Corrigendum to "Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats".	Hydrogen	16-24	PPARG coactivator 1 alpha	Rattus norvegicus	102-108
33346754-3	2021	For the band insulator ThO2, surface metallicity induced by hydrogen adsorption is observed due to the electron donation of the hydrogen to the surface.	Hydrogen	60-68	THO complex 2	Homo sapiens	23-27
33346754-3	2021	For the band insulator ThO2, surface metallicity induced by hydrogen adsorption is observed due to the electron donation of the hydrogen to the surface.	Hydrogen	128-136	THO complex 2	Homo sapiens	23-27
33378193-0	2021	Hydrogen-Bond-Assisted Alignment of [MCu(SeO3)4Cl(H2O)]4- (M = Fe, Ga) Anionic Layers to Form Two Polar Oxychlorides: Pb2MCu(SeO3)4Cl(H2O).	Hydrogen	0-8	mitochondrial calcium uniporter	Homo sapiens	37-40
33378193-2	2021	They are isostructural and crystallize in the two-dimensional [MCu(SeO3)4Cl(H2O)]4- anionic layer structure mediated with hydrogen bonds and aligned between neighboring layers which assist in building the three-dimensional framework with a polar space group.	Hydrogen	122-130	mitochondrial calcium uniporter	Homo sapiens	63-66
33310290-12	2021	Compound 1h induces apoptosis and necrosis in Hep-G2 cell line, as shown by caspase-3/7 and lactate dehydrogenase (LDH) release assays, respectively.	Hydrogen	9-11	caspase 3	Homo sapiens	76-87
32846304-6	2021	Molecular docking studies with Human Serum Albumin (HSA: PDB 1E78) showed binding pattern with the residues Arg218, Arg222, Lys195 and Lys444 in sub domain II A of site I via hydrogen bond and identifies the ligand-HSA interaction and specific insight for transportation to the target sites.	Hydrogen	175-183	albumin	Homo sapiens	37-50
33446077-7	2021	The active chemical constituents exhibited good docking scores, and interacts with binding site residues of Mpro by forming hydrogen bond and hydrophobic interactions.	Hydrogen	124-132	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	108-112
33395296-11	2021	Field-dependent variation in the salt bridge nets and the number of hydrogen bonds between FN and HA were also examined.	Hydrogen	68-76	fibronectin 1	Homo sapiens	91-93
33397109-3	2021	These collision adducts undergo a nonstatistical unimolecular decomposition through atomic hydrogen elimination to at least the cyclic 1-vinyl-cyclopropene (p5/p26), 1-methyl-3-methylenecyclopropene (p28), and 1,2-bis(methylene)cyclopropane (p29) in overall exoergic reactions.	Hydrogen	91-99	solute carrier family 10 member 5	Homo sapiens	157-164
33441668-3	2021	In the present study, the redox-dependent interaction of cyt c with CL was investigated through amide hydrogen/deuterium exchange coupled with mass spectrometry (HDXMS) and quartz crystal microbalance with dissipation monitoring (QCM-D).	Hydrogen	102-110	cytochrome c, somatic	Homo sapiens	57-62
32935922-3	2021	Herein, a highly efficient strategy to access well-defined site-specific functionalized polypeptides is developed by combining Michael reaction with hydrogen-bonding organocatalytic ROP of NCA.	Hydrogen	149-157	CEA cell adhesion molecule 4	Homo sapiens	189-192
33435425-8	2021	The number of carbon atoms in the sp3 covalent carbon without bonding with hydrogen and the logarithm of the hydrogen content were inversely proportional.	Hydrogen	75-83	Sp3 transcription factor	Homo sapiens	34-37
33435425-8	2021	The number of carbon atoms in the sp3 covalent carbon without bonding with hydrogen and the logarithm of the hydrogen content were inversely proportional.	Hydrogen	109-117	Sp3 transcription factor	Homo sapiens	34-37
33268465-5	2021	Hydrogen-deuterium exchange mass spectrometry (HDX-MS) analysis revealed that CUL5 neddylation allosterically exposes its ARIH2 binding site, promoting high affinity binding, and it also sequesters the NEDD8 E2 (UBE2F) binding site on RBX2.	Hydrogen	0-8	ariadne RBR E3 ubiquitin protein ligase 2	Homo sapiens	122-127
33220304-4	2021	Here, amide hydrogen/deuterium exchange with mass spectrometric analysis (HDX-MS) coupled with proteolytic digestion was used to identify the early stage interactions leading to fibrillation of human calcitonin (hCT), a peptide hormone important in calcium metabolism.	Hydrogen	12-20	calcitonin related polypeptide alpha	Homo sapiens	200-210
33122085-6	2021	The formation of Y4: P38 hydrogen-bond interaction between the peptide and eIF4E is a rate limiting event in the efficient recognition of the protein since it occurs through the disordered region of the peptide.	Hydrogen	25-33	mitogen-activated protein kinase 14	Homo sapiens	21-24
33485488-15	2021	The behavior of the lead compound has shown more compactness with an increased number of intermolecular hydrogen bonds in the ERBB2 with L755S.	Hydrogen	104-112	erb-b2 receptor tyrosine kinase 2	Homo sapiens	126-131
33387249-8	2021	Surpass potentialities of TMC-310911 and ritonavir are returned to their capabilities of forming multiple hydrogen bonds with the proximal amino acids inside Mpro"s binding site.	Hydrogen	106-114	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	158-162
32698735-9	2021	Molecular docking studies proved that the compound R8 has good binding fitting by forming hydrogen bonds with amino acid residues at ATP binding sites of EGFR.	Hydrogen	90-98	epidermal growth factor receptor	Homo sapiens	154-158
32698735-12	2021	Molecular docking studies reveled that compound R8 has good fitting by forming different Hydrogen bonding interactions with amino acids at ATP binding site of epidermal growth factor receptor target.	Hydrogen	89-97	epidermal growth factor receptor	Homo sapiens	159-191
33007506-2	2021	The NPC-D with H2O2-sensitive linker was dispersed well in water and simultaneously interacted with nucleic acids including plasmids encoding miR-122 (p122) and EpCAM-targeted aptamer (ap1) via charge interaction and hydrogen bonding.	Hydrogen	217-225	epithelial cell adhesion molecule	Homo sapiens	161-166
33161110-7	2021	Molecular docking suggested that the CuIIb-EGFR binding fundamentally depends on the contribution of both hydrophobic and hydrogen-bonding interactions.	Hydrogen	122-130	epidermal growth factor receptor	Homo sapiens	43-47
33449861-6	2021	Using docking analysis, we found that two compounds showed the best returned pose at ACE active sites, and formed hydrogen and hydrophobic bonds with ACE residues.	Hydrogen	114-122	angiotensin I converting enzyme	Rattus norvegicus	85-88
32219872-7	2021	Nrf2 deficiency inhibited the H2 S-induced beneficial impacts in Nrf2-/- mice.	Hydrogen	30-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
32219872-7	2021	Nrf2 deficiency inhibited the H2 S-induced beneficial impacts in Nrf2-/- mice.	Hydrogen	30-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	65-69
32219872-10	2021	In conclusion, H2 S-mediated Keap1 S-sulfhydration alleviates liver damage via activation of Nrf2.	Hydrogen	15-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
33475951-7	2021	The characteristic 1H-13C chemical shift correlations of isoAsp, N-terminal Pro and C-terminal Asp under standardized conditions were used to identify these PTMs in lysozyme and in the therapeutic mAb rituximab (MabThera) upon prolonged storage under acidic conditions (pH 4-5) and 40  C. The results show that the application of our 2D NMR-based protocol is straightforward and allows detecting chemical changes of proteins that may be otherwise unnoticed with other analytical methods.	Hydrogen	19-21	lysozyme	Homo sapiens	165-173
33020904-4	2021	Molecular dynamics simulations support the inference that crowding reduces binding interaction between actin filaments and fascin or the calphonin homology 1 domain of alpha-actinin evidenced by interaction energy and hydrogen bonding analysis.	Hydrogen	218-226	actinin alpha 1	Homo sapiens	168-181
32814187-0	2021	Nitrogen-rich g-C3N4@AgPd Mott-Schottky heterojunction boosts photocatalytic hydrogen production from water and tandem reduction of NO3- and NO2.	Hydrogen	77-85	NBL1, DAN family BMP antagonist	Homo sapiens	132-135
32814187-6	2021	The strategy opens a new way for making the photocatalytic hydrogen production in tandem with reduction of NO3- and NO2- in water, also extending it to remove metal ion.	Hydrogen	59-67	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
33166864-6	2021	It was found that hydrophobic interactions, along with hydrogen-bonding via the imidazole nitrogen heteroatom, promoted interactions with the Abeta peptide, thereby limiting its aggregation.	Hydrogen	55-63	amyloid beta precursor protein	Homo sapiens	142-147
33449861-6	2021	Using docking analysis, we found that two compounds showed the best returned pose at ACE active sites, and formed hydrogen and hydrophobic bonds with ACE residues.	Hydrogen	114-122	angiotensin I converting enzyme	Rattus norvegicus	150-153
32949090-3	2020	The SAP-Mo 2 C-CS is structurally stable and shows exceptional electrocatalytic activity for the hydrogen evolution reaction (HER).	Hydrogen	97-105	SH2 domain containing 1A	Homo sapiens	4-7
32590694-13	2021	The present study showed that hydrogen gas therapy increased the 7-day survival rate, improved cognitive function, increased the mitochondrial function (MMP, ATP level, complex I activity) and expression of mitochondrial biogenesis parameters (PGC-1alpha, NRF2, Tfam).	Hydrogen	30-38	nuclear factor, erythroid derived 2, like 2	Mus musculus	256-260
33374155-5	2020	Our synthesized compounds were promising, demonstrating high selectivity and affinity for EGFR/HER2, especially the hinge region forming a hydrophobic pocket, which was mediated by hydrogen bonding as well as hydrophobic and electrostatic interactions, as indicated by molecular modeling.	Hydrogen	181-189	epidermal growth factor receptor	Homo sapiens	90-94
33374155-5	2020	Our synthesized compounds were promising, demonstrating high selectivity and affinity for EGFR/HER2, especially the hinge region forming a hydrophobic pocket, which was mediated by hydrogen bonding as well as hydrophobic and electrostatic interactions, as indicated by molecular modeling.	Hydrogen	181-189	erb-b2 receptor tyrosine kinase 2	Homo sapiens	95-99
32407282-9	2021	Docking studies revealed important hydrogen bonding interactions with InhA.	Hydrogen	35-43	inhibin subunit alpha	Homo sapiens	70-74
32407282-11	2021	Docking studies of compounds explained the presence of hydrogen bonding and pi-pi stacking interactions with InhA.	Hydrogen	55-63	inhibin subunit alpha	Homo sapiens	109-113
33349011-15	2021	Intracisternal magnesium sulfate infusion combined with intravenous hydrogen therapy decreases serum malondialdehyde and neuron-specific enolase and improves Barthel index, indicating hydrogen has additional effects.	Hydrogen	68-76	enolase 2	Homo sapiens	121-144
33374431-11	2020	In addition, asparagine at codon 166 of cat PrP was predicted to have longer hydrogen bond than aspartic acid at codon 163 of canine PrP.	Hydrogen	77-85	prion protein	Canis lupus familiaris	44-47
33274636-4	2020	Here, we found that a hydrogen bond formed between DMBF and G277 of the D. melanogaster GABAR model might be the key interaction for the antagonism of DMBF by in silico simulations.	Hydrogen	22-30	Resistant to dieldrin	Drosophila melanogaster	88-93
33284003-7	2020	The molecular docking results showed that p-NH interacted with PHF6 fibrils mainly through van der Waals forces and hydrogen bonding and could inhibit PHF6 aggregation in a d-configuration and concentration-dependent manner.	Hydrogen	116-124	PHD finger protein 6	Mus musculus	63-67
33352819-0	2020	Evaluation of High-Temperature Hydrogen Sensors Based on BaCe0.6Zr0.3Y0.1O3-alpha and Sr(Ce0.9Zr0.1)0.95Yb0.05O3-alpha Perovskites for Industrial Applications.	Hydrogen	31-39	beta-secretase 1	Homo sapiens	57-61
33352819-5	2020	In the present work, amperometric hydrogen sensors were constructed and evaluated using two solid-state electrolytes, BaCe0.6Zr0.3Y0.1O3-alpha and Sr(Ce0.9Zr0.1)0.95Yb0.05O3-alpha.	Hydrogen	34-42	beta-secretase 1	Homo sapiens	118-122
33339390-3	2020	The Q-PAES/PPO-XY (quaternized-PAES/PPO-XY) blended membranes promoted the ion channel formation as the strong hydrogen bonds interconnecting the two polymers were maintained, and showed an improved hydroxide conductivity with excellent thermal behavior.	Hydrogen	111-119	protoporphyrinogen oxidase	Homo sapiens	11-14
33002535-3	2020	ATR-FTIR confirmed the existence of intermolecular hydrogen bonding between SA/mPEG in bio-polymeric membranes.	Hydrogen	51-59	ATR serine/threonine kinase	Homo sapiens	0-3
33333951-5	2020	We summarize the functions of hydrogen as a regulator of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated redox signaling and the association of hydrogen with mitochondria as an important target of its therapeutic action.	Hydrogen	30-38	NFE2 like bZIP transcription factor 2	Homo sapiens	57-100
33333951-5	2020	We summarize the functions of hydrogen as a regulator of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated redox signaling and the association of hydrogen with mitochondria as an important target of its therapeutic action.	Hydrogen	30-38	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
33302356-6	2020	All the DEHP metabolites interacted with the ligand-binding pocket of AR forming amino-acid residue interactions, hydrogen bonding, and pi-pi interactions.	Hydrogen	114-122	androgen receptor	Homo sapiens	70-72
33058920-6	2020	Molecular docking and other studies confirmed that curcumin could bind to and upregulate the expression of TET2 and TET3 with hydrogen bonds and arene-H bonds, suggesting that demethylation of RB1 was attributed to reactivation of the demethylation enzymes TET2 and TET3 after curcumin treatment.	Hydrogen	126-134	tet methylcytosine dioxygenase 3	Mus musculus	116-120
33063990-6	2020	Combining the ellipsometry and ATR-IR spectroscopy results, we find that increases in the order of the hydrogen bond network of the hydration water, as specified by the ATR-IR parameter Rnetwork, lead to linear increases in K and corresponding inverse changes in lambda.	Hydrogen	103-111	ATR serine/threonine kinase	Homo sapiens	31-34
33063990-6	2020	Combining the ellipsometry and ATR-IR spectroscopy results, we find that increases in the order of the hydrogen bond network of the hydration water, as specified by the ATR-IR parameter Rnetwork, lead to linear increases in K and corresponding inverse changes in lambda.	Hydrogen	103-111	ATR serine/threonine kinase	Homo sapiens	169-172
33060199-4	2020	Here, we present the room-temperature neutron structure of 3CL Mpro, which allowed direct determination of hydrogen atom positions and, hence, protonation states in the protease.	Hydrogen	107-115	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	63-67
33322407-5	2020	The MCLR/MCLR biodegradation products combined with PP1 mainly by the aid of interactions related to the active sites Adda5, Glu6, Mdha7, and the ionic bonds/hydrogen bonds between the integral toxin and PP1.	Hydrogen	158-166	inorganic pyrophosphatase 1	Homo sapiens	52-55
33322407-5	2020	The MCLR/MCLR biodegradation products combined with PP1 mainly by the aid of interactions related to the active sites Adda5, Glu6, Mdha7, and the ionic bonds/hydrogen bonds between the integral toxin and PP1.	Hydrogen	158-166	inorganic pyrophosphatase 1	Homo sapiens	204-207
33302356-9	2020	In addition, all the DEHP metabolites and testosterone showed a common hydrogen bonding interaction with amino-acid Arg-752 of AR.	Hydrogen	71-79	androgen receptor	Homo sapiens	127-129
32958253-7	2020	The 1H-15N HSQC NMR titrations revealed the probable requisite dynamics of S100A6m and S100B interfaces.	Hydrogen	4-6	S100 calcium binding protein B	Homo sapiens	87-92
33376898-7	2020	In addition, among these compounds, those with hydrogen at the 4"-position (2a and 2c) selectively inhibited the COX-2 enzyme.	Hydrogen	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
33277614-6	2020	Hydrogen deuterium exchange MS showed that Rab1, Rab11 and Rab43 share a conserved binding interface.	Hydrogen	0-8	RAB43, member RAS oncogene family	Homo sapiens	59-64
32930440-8	2020	Ordered arrangement of tetrapeptides within the nanosphere with the backbone hydrogen bonding led to a beta sheet formation.	Hydrogen	77-85	amyloid beta precursor protein	Homo sapiens	101-107
33227195-5	2020	The calculations have predicted that the bulky diol 1,4-Bis(2-hydroxy-2-propyl)benzene, which has distant hydroxyl groups, is able to catalyze nucleophilic fluorination in combination with 18-crown-6 via two hydrogen bonds to the SN2 transition state.	Hydrogen	208-216	solute carrier family 38 member 5	Homo sapiens	230-233
32882610-5	2020	A crystal structure of an inhibitor-menin complex revealed a compact conformation of the ligand molecule, which is stabilized not only by the introduction of a covalent linker but also three intramolecular hydrogen bonds.	Hydrogen	206-214	menin 1	Homo sapiens	36-41
33344505-4	2020	A network of hydrogen bonds and stacking interactions extending from the helix V of of CaM, and the residues of the switches A, B and C, and connecting to catalytic site residues, is a plausible candidate for the mediation of allosteric communication.	Hydrogen	13-21	calmodulin 1	Homo sapiens	87-90
33344518-2	2020	We previously demonstrated that sodium/glucose cotransporter 2 inhibitors (SGLT2i"s) have direct cardiac effects on ion homeostasis, possibly through inhibition of the cardiac sodium/hydrogen exchanger (NHE-1).	Hydrogen	183-191	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	203-208
32097610-6	2020	Cryoablation could also be combined with Hydrogen gas molecules, which were shown recently to stimulate peroxisome proliferator activated receptor gamma coactivator (PGC)-1alpha, thereby promoting mitochondrial function, which might rescue exhausted CD8+ T cells, leading to prolonged progression-free survival and overall survival of patients with advanced colorectal cancer.	Hydrogen	41-49	PPARG coactivator 1 alpha	Homo sapiens	104-177
32682034-4	2020	Our results demonstrate an entropy-driven spontaneous interaction between insulin and TA, where hydrogen bonds act as the main enthalpic contribution.	Hydrogen	96-104	insulin	Homo sapiens	74-81
33185634-6	2020	Computational modeling showed that S1 and S2 could form hydrogen bonds with the SH2 domain of STAT3.	Hydrogen	56-64	signal transducer and activator of transcription 3	Mus musculus	94-99
33335874-4	2020	To understand the genotype-phenotype relationships of the in-frame deletion in the MBOAT7 gene, we located the variant in the fifth transmembrane domain of the protein and determined that it causes steric hindrance to the formation of an alpha-helix and hydrogen bond, possibly influencing its effectiveness as a functional transmembrane protein.	Hydrogen	254-262	membrane bound O-acyltransferase domain containing 7	Homo sapiens	83-89
33329667-5	2020	Docking characterization predicted that these compounds bound to three or four subsites (S1, S1", S2, and S4) in the binding pocket of Mpro via different spatial ways and various formation of one to four hydrogen bonds.	Hydrogen	204-212	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	135-139
33065814-8	2020	Molecular docking results suggested that Esc bound to CCR5 at amino acid residues TYR187 and THR105 through hydrogen-bonding.	Hydrogen	108-116	chemokine (C-C motif) receptor 5	Mus musculus	54-58
33424246-14	2020	Molecular docking showed hydrogen bonding interactions (binding energies: -11.3 to -7.8 kcal/mol) with arachidonate 5 lipoxygenase, NFkappab and glucocorticoid receptor.	Hydrogen	25-33	arachidonate 5-lipoxygenase	Homo sapiens	103-130
33424246-14	2020	Molecular docking showed hydrogen bonding interactions (binding energies: -11.3 to -7.8 kcal/mol) with arachidonate 5 lipoxygenase, NFkappab and glucocorticoid receptor.	Hydrogen	25-33	nuclear factor kappa B subunit 1	Homo sapiens	132-140
33424246-14	2020	Molecular docking showed hydrogen bonding interactions (binding energies: -11.3 to -7.8 kcal/mol) with arachidonate 5 lipoxygenase, NFkappab and glucocorticoid receptor.	Hydrogen	25-33	nuclear receptor subfamily 3 group C member 1	Homo sapiens	145-168
33265979-1	2020	The selectivity of encapsulation of leflunomide and teriflunomide by native alpha-, beta- and gamma-cyclodextrins was investigated through 1H NMR and molecular modeling.	Hydrogen	139-141	amyloid beta precursor protein	Homo sapiens	76-89
31821667-5	2020	TRAIL induced a high level of fatigue and mild exercise-induced muscle damage, as determined by a reduction in MVC (-9.4%, p &lt; .01, d = -1.36) and increases in [CK] (+176.0%, p &lt; .01, d = 1.49) and perceived muscle soreness (+4.5 UA, p &lt; .01, d = 2.17) compared with REST at H24.	Hydrogen	284-287	TNF superfamily member 10	Homo sapiens	0-5
32864834-3	2020	Due to the introduction of CP group on beta-CD, it disrupts the hydrogen network between natural beta-CD molecules.	Hydrogen	64-72	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	39-46
32864834-3	2020	Due to the introduction of CP group on beta-CD, it disrupts the hydrogen network between natural beta-CD molecules.	Hydrogen	64-72	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	97-104
32869957-1	2020	Functional supramolecular micelles containing self-complementary multiple hydrogen bonding adenine groups (A-PPG) can spontaneously self-assemble into stable nanosized micelles in aqueous solution.	Hydrogen	74-82	serglycin	Homo sapiens	109-112
33252029-5	2022	Furthermore, molecular docking revealed that the binding energy (-9.74 kcal/mol) and inhibition constant (0.071 micromol) correlate with the activity of the most active compound that forms hydrophobic interactions and two hydrogen bonds with the the dual specificity tyrosine phosphorylation regulated kinase 1 A (DYRK1A).	Hydrogen	222-230	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	250-312
33252029-5	2022	Furthermore, molecular docking revealed that the binding energy (-9.74 kcal/mol) and inhibition constant (0.071 micromol) correlate with the activity of the most active compound that forms hydrophobic interactions and two hydrogen bonds with the the dual specificity tyrosine phosphorylation regulated kinase 1 A (DYRK1A).	Hydrogen	222-230	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	314-320
32726695-11	2020	These results help to further understand the role of elevated hydrogen amendment in the PCB biodegradation process and provide evidence that H2 supports metabolic and energetic flexibility in microorganisms supplying a range of ecosystem services.	Hydrogen	62-70	pyruvate carboxylase	Homo sapiens	88-91
32736114-9	2020	In silico docking methods elucidate the contribution of hydrogen bonds and hydrophobic contacts towards the binding of 2"-OH-PCB61 and 2"-OH-PCB65 with CES1 and CES2.	Hydrogen	56-64	carboxylesterase 2	Homo sapiens	161-165
32810401-5	2020	Where experimental data was available, mutations from hydrogen to a methyl group at sites highlighted by the optimizer were calculated with MBAR and the mean unsigned error between experimental and calculated values of the binding free energy was 0.83 kcal/mol.	Hydrogen	54-62	G protein-coupled bile acid receptor 1	Homo sapiens	140-144
33175558-6	2020	Analyses of the hydrogen bonds and atomic interactions further provided detailed explanations for the resistance of these four mutation proteases toward inhibitor GRL-02031.	Hydrogen	16-24	nuclear receptor subfamily 3 group C member 1	Homo sapiens	163-166
32653374-6	2020	The thermodynamic analysis showed that van der Waals and hydrogen binding forces play a major role in the interaction of erlotinib with EGFR.	Hydrogen	57-65	epidermal growth factor receptor	Homo sapiens	136-140
33329557-6	2020	Bioinformatics tools and computational modeling revealed that NLRP3 mutations that are predicted to be structurally severely-disruptive localize around the ATP binding pocket and that specific proteo-structural changes to the ATP binding pocket lead to enhanced ATP binding affinity by altering hydrogen-bond and charge interactions.	Hydrogen	295-303	NLR family pyrin domain containing 3	Homo sapiens	62-67
33222104-6	2020	Molecular dynamics (MD) simulation revealed lycopene molecule was wrapped within the aggregates of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and PEG 6000 through extensive hydrogen bond interactions, which was experimentally validated by DSC, XRD, and FTIR spectrum analysis.	Hydrogen	175-183	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	135-142
33222104-7	2020	The third component PEG 6000 facilitated the process of HME and augmented hydrogen bond interactions with HP-beta-CD.	Hydrogen	74-82	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	109-116
33153146-8	2020	Compound 14 showed the formation of hydrogen bonding with Cys673, Glu640, and Asp810 in c-KIT, and Cys677, Glu644, and Asp836 in PDGFRalpha.	Hydrogen	36-44	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	88-93
33209018-0	2020	iTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment.	Hydrogen	94-102	gastrin	Mus musculus	103-106
33209018-2	2020	Our research team has proven that inhaling 2% hydrogen gas (H2) can effectively improve sepsis and related organ damage, but the specific molecular mechanism of its role is not clear.	Hydrogen	46-54	gastrin	Mus musculus	55-58
32623304-9	2020	The red-shifted characteristic peaks of [beta-CD + l-Peni + H]+ in IRMPD spectra owe to the stronger NH O hydrogen bonds.	Hydrogen	106-114	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	41-48
33184287-5	2020	All-atom molecular dynamics simulations indicate that the FUS-LC-C fibril core is stabilized by a plethora of hydrogen bonds involving sidechains of Gln, Asn, Ser, and Tyr residues, both along and transverse to the fibril growth direction, including diverse sidechain-to-backbone, sidechain-to-sidechain, and sidechain-to-water interactions.	Hydrogen	110-118	FUS RNA binding protein	Homo sapiens	58-61
33172102-6	2020	Furthermore, the molecular modeling study indicated a high selectivity and promising affinity of our prepared compounds to COX-2, especially the hydrophobic pocket and the mouth of the active site holding hydrogen-bonding, hydrophobic, and electrostatic interactions.	Hydrogen	205-213	prostaglandin-endoperoxide synthase 2	Homo sapiens	123-128
33065432-8	2020	Immunohistochemistry and molecular modeling demonstrated that compound 2d significantly inhibited the expression of iNOS in vivo and interacted with iNOS through two hydrogen bindings with the MET368 and ILE195 residues of the iNOS protein.	Hydrogen	166-174	nitric oxide synthase 2, inducible	Mus musculus	116-120
32919131-2	2020	The structure-activity relationship (SAR) and molecular docking result showed that the presence of hydroxyl group at C-5 of PL might interact with STAT3 in the form of hydrogen bonds, which is conducive to the binding of this kind structures with STAT3.	Hydrogen	168-176	signal transducer and activator of transcription 3	Homo sapiens	147-152
32919131-2	2020	The structure-activity relationship (SAR) and molecular docking result showed that the presence of hydroxyl group at C-5 of PL might interact with STAT3 in the form of hydrogen bonds, which is conducive to the binding of this kind structures with STAT3.	Hydrogen	168-176	signal transducer and activator of transcription 3	Homo sapiens	247-252
33065432-8	2020	Immunohistochemistry and molecular modeling demonstrated that compound 2d significantly inhibited the expression of iNOS in vivo and interacted with iNOS through two hydrogen bindings with the MET368 and ILE195 residues of the iNOS protein.	Hydrogen	166-174	nitric oxide synthase 2, inducible	Mus musculus	149-153
33065432-8	2020	Immunohistochemistry and molecular modeling demonstrated that compound 2d significantly inhibited the expression of iNOS in vivo and interacted with iNOS through two hydrogen bindings with the MET368 and ILE195 residues of the iNOS protein.	Hydrogen	166-174	nitric oxide synthase 2, inducible	Mus musculus	149-153
32632681-4	2020	Then, the DBP, DNOP, and DMP molecules in environmental priority control pollutants were selected as the target molecules to perform common substitution reactions of hydrogen bond donor.	Hydrogen	166-174	D-box binding PAR bZIP transcription factor	Homo sapiens	10-13
32593825-8	2020	Hydrogen bonding through host-guest inclusion and electrostatic interactions could respectively attribute to uptake of BPA and MB/NR onto SB-beta-CD.	Hydrogen	0-8	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	141-148
33065388-6	2020	Binding mode analysis demonstrated the ability of salvianolic acid A and curcumin to form nine and six hydrogen bonds, respectively with amino acids proximal to Mpro"s active site.	Hydrogen	103-111	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	161-165
32129539-6	2020	Insulinogenic index and adiponectin levels were significantly lower in the High 1h-PG group than in the Low 1h-PG group.	Hydrogen	80-82	adiponectin, C1Q and collagen domain containing	Homo sapiens	24-35
33182041-9	2020	Finally, molecule docking was performed to simulate the complex interactions of scFv 4E and VEGF, the main driving forces of which involve the hydrophobic interactions and hydrogen bonds of Tyr108 and Tyr 109 of the complementarity-determining region H3 loop with VEGF.	Hydrogen	172-180	vascular endothelial growth factor A	Homo sapiens	92-96
32129539-8	2020	In conclusion, nonobese Japanese men with high 1h-PG have impaired early-phase insulin secretion and lower adiponectin levels.	Hydrogen	47-49	adiponectin, C1Q and collagen domain containing	Homo sapiens	107-118
32234461-0	2020	Molecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 Signaling.	Hydrogen	10-18	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
32234461-6	2020	H2 protected mitochondrial morphology and function in melanocytes under stress and promoted the activation of nuclear erythroid 2-related factor (Nrf2) signaling, while Nrf2 deficiency abolished the protective effect of H2 against H2O2-induced oxidative damage.	Hydrogen	0-2	NFE2 like bZIP transcription factor 2	Homo sapiens	146-150
32234461-6	2020	H2 protected mitochondrial morphology and function in melanocytes under stress and promoted the activation of nuclear erythroid 2-related factor (Nrf2) signaling, while Nrf2 deficiency abolished the protective effect of H2 against H2O2-induced oxidative damage.	Hydrogen	220-222	NFE2 like bZIP transcription factor 2	Homo sapiens	169-173
32234461-7	2020	Furthermore, H2 positively modulated beta-catenin in H2O2-treated melanocytes, and the beta-catenin pathway was implicated in H2-induced Nrf2 activation.	Hydrogen	53-55	NFE2 like bZIP transcription factor 2	Homo sapiens	137-141
32234461-8	2020	Collectively, our results indicate that H2 could be a promising therapeutic agent for vitiligo treatment via attenuating oxidative damage, and its beneficial effect in human melanocytes might involve Wnt/beta-catenin-mediated activation of Nrf2 signaling.	Hydrogen	40-42	NFE2 like bZIP transcription factor 2	Homo sapiens	240-244
32997862-12	2020	IR-induced upregulation of proinflammatory cytokine mRNAs such as IL-6 was mitigated by hydrogen treatment.	Hydrogen	88-96	interleukin 6	Rattus norvegicus	66-70
33828360-10	2020	A total of four hydrogen bonds, four hydrophobic contacts, and one electrostatic interaction were detected in the docked fisetin-Bcl-xl complex, explaining its high binding affinity with Bcl-xl.	Hydrogen	16-24	BCL2 like 1	Homo sapiens	129-135
32557910-7	2020	Combining our simulation with the map of disease mutation sites in RyR1, we constructed a wiring diagram of key domains coupled via specific hydrogen bonds involving the mutation sites, some of which were modulated by Ca2+ binding.	Hydrogen	141-149	ryanodine receptor 1	Homo sapiens	67-71
33463500-0	2020	[Hydrogen plays a protective role in intestinal injury of mice with severe sepsis by regulating the release of heme oxygenase-1 and high mobility group protein B1].	Hydrogen	1-9	heme oxygenase 1	Mus musculus	111-127
32048433-10	2020	These studies reveal that the benzodioxole moiety exhibits strong interactions due to hydrogen bonds that form with the Glu201 (AChE) and Tyr440 (BChE) residues, which is reflected in the IC 50 values.	Hydrogen	86-94	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
33142859-4	2020	1H NMR and mass spectrometry-based metabolomics, in combination with bioinformatic analyses, provided useful information highlighting previously unreported biochemical pathways and CSF-based biomarkers associated with both sporadic PD (sPD) and LRRK2 PD.	Hydrogen	0-2	leucine rich repeat kinase 2	Homo sapiens	245-250
33463500-1	2020	OBJECTIVE: To investigate the protective effect of the hydrogen (H2) inhalation on intestinal injury in severe sepsis mice and its relationship with nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/high mobility group protein B1 (HMGB1) pathway.	Hydrogen	55-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	149-183
33463500-1	2020	OBJECTIVE: To investigate the protective effect of the hydrogen (H2) inhalation on intestinal injury in severe sepsis mice and its relationship with nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/high mobility group protein B1 (HMGB1) pathway.	Hydrogen	55-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	185-189
33463500-1	2020	OBJECTIVE: To investigate the protective effect of the hydrogen (H2) inhalation on intestinal injury in severe sepsis mice and its relationship with nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/high mobility group protein B1 (HMGB1) pathway.	Hydrogen	55-63	heme oxygenase 1	Mus musculus	191-207
33463500-1	2020	OBJECTIVE: To investigate the protective effect of the hydrogen (H2) inhalation on intestinal injury in severe sepsis mice and its relationship with nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/high mobility group protein B1 (HMGB1) pathway.	Hydrogen	55-63	heme oxygenase 1	Mus musculus	209-213
33124956-9	2022	The "extended" complex is maintained by formation of several persistent hydrogen bonds between the IL-1RI-IL-1RAcP inter-connected glycans.	Hydrogen	72-80	interleukin 1 receptor type 1	Homo sapiens	99-105
33124956-9	2022	The "extended" complex is maintained by formation of several persistent hydrogen bonds between the IL-1RI-IL-1RAcP inter-connected glycans.	Hydrogen	72-80	interleukin 1 receptor accessory protein	Homo sapiens	106-114
32915574-7	2020	Molecular docking indicated that these dipeptides formed hydrogen bonds with ACE.	Hydrogen	57-65	angiotensin I converting enzyme	Homo sapiens	77-80
32865967-5	2020	Molecular docking studies with CRBN and GSPT1 followed by analog synthesis identified a possible hydrogen bond interaction with the central pyrimidine ring as a molecular determinant of hit compounds" selectivity.	Hydrogen	97-105	cereblon	Homo sapiens	31-35
32415672-6	2020	Single crystal X-ray analysis indicated that POP-oNH2-Py provided a stronger complex compared to POP-pNH2-Py due to the intramolecular hydrogen bonding between the amino group and coordinated chlorine molecules.	Hydrogen	135-143	phosphatidylinositol glycan anchor biosynthesis class T	Homo sapiens	101-105
33096664-10	2020	However, molecular dynamics simulations demonstrated that only ZINC16525481 and ZINC38484632 which have good binding free energy and stable hydrogen bonding interactions with EGFR and VEGFR2.	Hydrogen	140-148	epidermal growth factor receptor	Homo sapiens	175-179
33077854-4	2021	GSH in dorsal anterior cingulate cortex (dACC) was acquired as a secondary 3T 1H-MRS outcome using a MEGA-PRESS sequence.	Hydrogen	78-80	Acetyl-CoA carboxylase	Drosophila melanogaster	41-45
32869056-10	2020	Furthermore, the interaction between Cu(II)-L-histidine complex and beta-CD was also studied using Ultraviolet-visible and 1H NMR spectroscopy to explain the synergistic effect involved.	Hydrogen	123-125	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	68-75
32865967-5	2020	Molecular docking studies with CRBN and GSPT1 followed by analog synthesis identified a possible hydrogen bond interaction with the central pyrimidine ring as a molecular determinant of hit compounds" selectivity.	Hydrogen	97-105	G1 to S phase transition 1	Homo sapiens	40-45
32996507-3	2020	For the eight concerted routes, the cooperative bimetallic route in which the middle carbon atom is attacked by the nucleophilic oxygen atom (route VI-m) was calculated to be the most favorable, and among the three catalysts examined H2O-CoIII-OTs was found to be the most active, due to the strong hydrogen bonding between the nucleophilic H2O and the ring oxygen atom in the epoxides as well as the extra pi-pi stacking interaction.	Hydrogen	299-307	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	238-243
32931266-6	2020	In particular, a recently reported vibrational phase relationship between double-bond torsion and hydrogen-out-of-plane modes critical for rhodopsin isomerization efficiency is correctly reproduced.	Hydrogen	98-106	rhodopsin	Homo sapiens	139-148
32809833-4	2020	The proposed sensing method showed highly sensitive detection of caspase-3 based on just a simple enzymatic cleavage reaction within 1h.	Hydrogen	133-135	caspase 3	Homo sapiens	65-74
33066693-8	2020	In this complex, isatin is targeted to the interface of interacting FECH and ADR monomers, forming hydrogen bonds with both FECH and ADR.	Hydrogen	99-107	aldo-keto reductase family 1 member B	Homo sapiens	77-80
33066693-8	2020	In this complex, isatin is targeted to the interface of interacting FECH and ADR monomers, forming hydrogen bonds with both FECH and ADR.	Hydrogen	99-107	aldo-keto reductase family 1 member B	Homo sapiens	133-136
33150175-11	2020	Hydrogen bonds and ion bonds for above key sites were closely related to the inhibition effect of TCs on CAT.	Hydrogen	0-8	catalase	Homo sapiens	105-108
33053834-5	2020	Second, our molecular dynamic analyses have revealed that hCDK8 has higher hydrogen bond occupation of His149-Asp151 and Asp151-Asn156 than dCDK8.	Hydrogen	75-83	cyclin dependent kinase 8	Homo sapiens	58-63
33066201-2	2020	For example, the hydrogen bond is often a preliminary stage of the proton transfer process or the tetrel and pnicogen bonds lead sometimes to the SN2 reactions.	Hydrogen	17-25	solute carrier family 38 member 5	Homo sapiens	146-149
33053834-8	2020	Human CDK8 has higher hydrogen bond occupation between L312 and L316 than dCDK8.	Hydrogen	22-30	cyclin dependent kinase 8	Homo sapiens	6-10
33053834-9	2020	Moreover, L312, L315 and L316 in the LXXLL motif of CDK8 have the specific pattern of hydrogen bonds and geometries, which could be crucial for the binding to nuclear receptors.	Hydrogen	86-94	cyclin dependent kinase 8	Homo sapiens	52-56
33053834-10	2020	Furthermore, the P154L mutation dramatically decreases the hydrogen bond between L312 and L315 in hCDK8, but not in dCDK8.	Hydrogen	59-67	cyclin dependent kinase 8	Homo sapiens	98-103
33163405-6	2020	The docking study indicated that sapitinib interacted with the efflux site of ABCB1 transporter by pi-pi interaction and two hydrogen bonds.	Hydrogen	125-133	ATP binding cassette subfamily B member 1	Homo sapiens	78-83
33053697-4	2020	Meanwhile, the CuI mediated C-N coupling reactions of 4-iodo-1H-1-tritylpyrazole were effective for alkylamines possessing a beta-hydrogen atom.	Hydrogen	130-138	amyloid beta precursor protein	Homo sapiens	123-129
33053697-2	2020	The Pd(dba)2 catalyzed C-N coupling reaction of aryl- or alkylamines, lacking a beta-hydrogen atom, proceeded smoothly using tBuDavePhos as a ligand.	Hydrogen	85-93	DBA2	Homo sapiens	4-12
32969450-4	2020	We found that the conformational change of the beta1 sheet at the substrate entrance and the displacement of the beta" helix were critical for reshaping the binding pocket to modulate substrate entrance and positioning the C-H to be activated toward the oxidative species of P450 for the subsequent hydrogen abstraction, the rate-determining step of hydroxylation.	Hydrogen	299-307	BCL2 related protein A1	Homo sapiens	47-52
32897695-5	2020	The higher potency of both at KOR over MOR may be due to hydrogen-bond formation between non-conserved Y7.35 of KOR and their carbonyl groups.	Hydrogen	57-65	opioid receptor, mu 1	Mus musculus	39-42
32941732-3	2020	Isotopic labeling studies revealed that both the H- and CO2 originate from the bound mu1,3-formate in 1H, which represents a key step of the metal-mediated formic acid dehydrogenation.	Hydrogen	102-104	glutathione S-transferase mu 1	Homo sapiens	85-88
32361817-0	2020	1H, 13C and 15N resonance assignments of TFIIS LW domain from Homo sapiens.	Hydrogen	0-2	transcription elongation factor A2	Homo sapiens	41-46
32350932-6	2020	Mechanistic investigations supported by Density Functional Theory (BP86) reveal that dihydrogen formation takes place in an intramolecular fashion through the participation of a methylene C-H bond of the HBMIM Ph2 ligand and a Co II -H bond through formal heterolytic splitting of the latter.	Hydrogen	85-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	227-232
32500230-0	2020	1H, 15N and 13C resonance assignments of the HR1c domain of PRK1, a protein kinase C-related kinase.	Hydrogen	0-2	polo like kinase 3	Homo sapiens	68-99
32236802-0	2020	1H, 13C, and 15N chemical shift assignment of human PACSIN1/syndapin I SH3 domain in solution.	Hydrogen	0-2	protein kinase C and casein kinase substrate in neurons 1	Homo sapiens	52-59
32236802-0	2020	1H, 13C, and 15N chemical shift assignment of human PACSIN1/syndapin I SH3 domain in solution.	Hydrogen	0-2	protein kinase C and casein kinase substrate in neurons 1	Homo sapiens	60-70
32583165-3	2020	Here were report 1H, 13C, and 15N resonance assignments for the intrinsically disordered BRCA1 fragment 219-504, which contains important interaction sites for the proto-oncogenic transcription factor MYC as well as for p53.	Hydrogen	17-19	tumor protein p53	Homo sapiens	220-223
32778291-5	2020	Up to 468 mL L-1 of hydrogen and 203 mg L-1 of poly-beta-hydroxybutyrate can be produced starting from an initial chemical oxygen demand of 1500 mg L-1.	Hydrogen	20-28	L1 cell adhesion molecule	Homo sapiens	13-16
32726718-5	2020	RESULTS: The computational calculations revealed that amygdalin inhibits the selected targets via block the ATP-binding pocket of AKT1, FAK, and ILK by forming stable hydrogen bonds.	Hydrogen	167-175	integrin linked kinase	Homo sapiens	145-148
32601839-8	2020	This study also enabled the determination of the structural requirements for interactions with the active site of PI4KIIIbeta, demonstrating the importance of both acceptor and donor hydrogen bonding groups for forming interactions with binding site residues Val598 and Lys549.	Hydrogen	183-191	phosphatidylinositol 4-kinase beta	Homo sapiens	114-125
32954977-4	2022	The PPAR-gamma-derivative complex was stabilized by intermolecular hydrogen bonds and stacking interactions.	Hydrogen	67-75	peroxisome proliferator activated receptor gamma	Homo sapiens	4-14
32707235-6	2020	We report the first 1H, 13C, 15N backbone NMR assignment of a Rab GTPase family member with Rab4a in complex with GDP and GTPgammaS.	Hydrogen	20-22	RAB4A, member RAS oncogene family	Homo sapiens	92-97
32649952-5	2020	In the current study, based on 1H-15N HSQC NMR experiments and HADDOCK results, S100A4 interacts with the intrinsically unstructured transactivation domain (TAD) of the protein p53 and the pentamidine molecules in the presence of calcium ions.	Hydrogen	31-33	tumor protein p53	Homo sapiens	177-180
32762381-9	2020	TX showed hydrogen bonding and hydrophobic interactions with elastase.Discussion: TNFalpha induces inflammation of 3T3-L1 cells through elastase activation.	Hydrogen	10-18	tumor necrosis factor	Mus musculus	82-90
32653595-2	2020	beta-CD and quetiapine form a host-guest inclusion complex at a ratio of 2:1 in which the beta-CD molecules form head-to-head dimers with their secondary hydroxyl groups linked by multiple hydrogen bonds.	Hydrogen	189-197	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	0-7
32653595-2	2020	beta-CD and quetiapine form a host-guest inclusion complex at a ratio of 2:1 in which the beta-CD molecules form head-to-head dimers with their secondary hydroxyl groups linked by multiple hydrogen bonds.	Hydrogen	189-197	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	90-97
32978402-4	2020	The unique up-field 1H-NMR chemical shift and the highly efficient incorporation of TMSiPhe enabled the characterization of multiple conformational states of a phospho-beta2 adrenergic receptor/beta-arrestin-1(beta-arr1) membrane protein signaling complex, using only 5 muM protein and 20 min of spectrum accumulation time.	Hydrogen	20-22	arrestin beta 1	Homo sapiens	194-209
33029259-2	2020	1H-MRS data were acquired from the basal ganglia at the following time points after HI: 6, 12, 24, and 72 h. Changes in protein levels of EAAT2 and GluR2 were determined by immunohistochemical analysis.	Hydrogen	0-2	solute carrier family 1 member 2	Homo sapiens	138-143
33029259-7	2020	Conclusions: Changes in Glu level measured by 1H-MRS were inversely correlated with those in EAAT2 and GluR2 protein levels following HI, and the results demonstrated that 1H-MRS can reflect the early changes of glutamatergic activity in vivo.	Hydrogen	46-48	solute carrier family 1 member 2	Homo sapiens	93-98
33029259-7	2020	Conclusions: Changes in Glu level measured by 1H-MRS were inversely correlated with those in EAAT2 and GluR2 protein levels following HI, and the results demonstrated that 1H-MRS can reflect the early changes of glutamatergic activity in vivo.	Hydrogen	172-174	solute carrier family 1 member 2	Homo sapiens	93-98
32830209-9	2020	The disruption of salt bridges and a notable decline in the number of hydrogen bonds and beta-sheet content explain the conformational changes in the Abeta fibril structure, ceasing their neurotoxicity.	Hydrogen	70-78	amyloid beta precursor protein	Homo sapiens	150-155
32361092-5	2020	Additionally, hydrogen-bonding interaction between SPI and WBC and the enhanced thermal stability were proposed in the composite gels.	Hydrogen	14-22	chromogranin A	Homo sapiens	51-54
32924825-8	2022	Dex showed stronger affinity to its theoretical (glucocorticoid) receptor with a superior docking score of -14.7 and a good binding energy value of -147.48 kcal/mol; while short hydrogen bond distances were observed in both Mpro and IL-6 when compared to glucocorticoid receptor.	Hydrogen	178-186	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	224-228
32935088-5	2020	Surprisingly, in addition to the orthosteric site common to morphinan opiates, fentanyl can move deeper and bind mOR through hydrogen bonding with a conserved histidine H297, which has been shown to modulate mOR"s ligand affinity and pH dependence in mutagenesis experiments, but its precise role remains unclear.	Hydrogen	125-133	opioid receptor, mu 1	Mus musculus	113-116
32812959-7	2020	Furthermore, complexation of L1 with Cu(BF4)2 H2O and Zn(CF3SO3)2 provided a 2D   3D interpenetrated network containing a classic dimeric copper paddle-wheel SBU, and an infinite 1D chain which extended into a 3D structure facilitated by hydrogen-bonding interactions, respectively.	Hydrogen	238-246	L1 cell adhesion molecule	Homo sapiens	29-31
32666189-4	2020	By molecular docking, it showed that there were hydrogen bonds, hydrophobic interactions, CH-pi interaction, and cation-pi interaction between 3-PBA and its scFv.	Hydrogen	48-56	immunglobulin heavy chain variable region	Homo sapiens	157-161
32588618-3	2020	By mass and 1H NMR spectral analysis, these products are cysteinyl-[2"-S-7]-1-CHO-DHP (P2), cysteinyl-[3"-N-7]-1-CHO-DHP (P3), 7-keto-DHP (P4), and 1-cysteinylimino-DHP (P5).	Hydrogen	12-14	dihydropyrimidinase	Homo sapiens	82-85
32914385-12	2020	Thus, 1H-MRS-based metabolomics was suitable to identify early inefficient energetic metabolism in neonatal KO-CSRP3 CMs.	Hydrogen	6-8	cysteine and glycine rich protein 3	Rattus norvegicus	111-116
32705198-10	2020	In addition, a molecular docking assay revealed that aconitine exerted strong affinity towards ERbeta mainly through hydrogen bonding and hydrophobic effects.	Hydrogen	117-125	estrogen receptor 1	Homo sapiens	95-101
32786398-3	2020	A complementary approach employing molecular dynamics simulations and hydrogen-deuterium exchange mass spectrometry (HDX-MS) was employed to interrogate the changes in CYP19A1 dynamics coupled to binding androstenedione (ASD).	Hydrogen	70-78	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	168-175
32839778-5	2020	Surprisingly, in addition to the orthosteric site common to morphinan opiates, fentanyl can move deeper and bind mOR through hydrogen bonding with a conserved histidine H297, which has been shown to modulate mOR"s ligand affinity and pH dependence in mutagenesis experiments, but its precise role remains unclear.	Hydrogen	125-133	opioid receptor, mu 1	Mus musculus	113-116
32815481-10	2021	Glutamic acid (Glu166) of Mpro is a key residue to hold and form a stable complex of reported lead compounds by forming hydrogen bonds and salt bridge.	Hydrogen	120-128	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	26-30
32821669-1	2020	AIM: To investigate the effects of hydrogen (H2) on Cu, Zn superoxide dismutase (SOD1) activation in a rat model of corneal alkali burn.	Hydrogen	35-43	superoxide dismutase 1	Rattus norvegicus	81-85
31547774-8	2020	All synthesized molecules (K1-K12) dock at junction p53-DNA and make hydrogen bonded with residues of p53 protein as per docking study.	Hydrogen	69-77	tumor protein p53	Homo sapiens	102-105
32806191-2	2020	This route features a very challenging Suzuki-Miyaura coupling to prepare the fully functionalized furan intermediate, a Negishi-type acylation to unite the two enantio-enriched fragments, and a subsequent hydrogen-atom-transfer-initiated 6-endo radical cyclization to install the central cyclohexadienone moiety, which establishes the C10 all-carbon quaternary stereocenter.	Hydrogen	206-214	homeobox C10	Homo sapiens	336-339
32879796-6	2020	The highest hydrogen and methane production of 8.7 m3 H2 ton-1 of high moisture MSW and 66.6 m3 CH4 ton-1 of high moisture MSW was achieved at organic loading of 43 gVS L-1 at IFA addition of 1% by two-stage AD process.	Hydrogen	12-20	COP9 signalosome subunit 4	Drosophila melanogaster	96-99
32686406-4	2020	In this work, ion mobility mass spectrometry, hydrogen deuterium exchange mass spectrometry and molecular dynamics simulation revealed the conformational dynamics of three class A beta-lactamases with varying inhibition efficiency by BLIP.	Hydrogen	46-54	amyloid beta precursor protein	Homo sapiens	178-184
32674759-2	2020	beta-cyclodextrin/11-mercaptoundecanoic acid self-assembled monolayer (beta-CD/MUA SAM) based on hydrogen bonds network was constructed as simulated enzyme-containing biomembrane.	Hydrogen	97-105	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	71-82
32674759-3	2020	DA interacted with beta-CD based on intermolecular hydrogen bond and formed inclusion complexes in SAM, namely DA@beta-CD/MUA SAM.	Hydrogen	51-59	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	19-26
32674759-3	2020	DA interacted with beta-CD based on intermolecular hydrogen bond and formed inclusion complexes in SAM, namely DA@beta-CD/MUA SAM.	Hydrogen	51-59	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	114-121
32674759-6	2020	The decrease of negative charge density of SAM resulted in the weakening of hydrogen bond between DA and beta-CD, which in turn caused DA to be released.	Hydrogen	76-84	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	105-112
32687356-0	2020	Hydrogen Bond Exchange and Ca2+ Binding of Aqueous N-Methylacetamide Revealed by 2DIR Spectroscopy.	Hydrogen	0-8	arginine vasopressin receptor 2	Homo sapiens	82-85
32281042-5	2020	Using peripheral blood samples, NR3C1 methylation in exons 1D, 1B, 1F, and 1H was assessed via sodium bisulfite treatment combined with the MethylTarget method.	Hydrogen	75-77	nuclear receptor subfamily 3 group C member 1	Homo sapiens	32-37
32697584-1	2020	We have found that terminal N-vinylindoles bearing cycloalkanone substituents are excellent hydrogen atom acceptors, generating alpha-aminyl radicals with a variety of catalysts (Co(II)/H2 or Co(III)Cl precatalysts with silane reductants).	Hydrogen	92-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-188
32179453-4	2020	Hydrogen is generated in the photocatalytic compartment by a Pt@g-C3N4 photocatalyst embedded into a hydrogen capture material composed of a polymer of intrinsic microporosity (PIM-1).	Hydrogen	0-8	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	177-182
32179453-4	2020	Hydrogen is generated in the photocatalytic compartment by a Pt@g-C3N4 photocatalyst embedded into a hydrogen capture material composed of a polymer of intrinsic microporosity (PIM-1).	Hydrogen	101-109	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	177-182
31598635-4	2020	In vitro evaluation showed that H3N-375TS was suppressed in pancreatic miR-375-expressing EndoC-betaH1 cells more than 5 log10, whereas its replication was not suppressed in isolated primary embryonic mouse cardiomyocytes.	Hydrogen	32-35	microRNA 375	Homo sapiens	71-78
32447221-0	2020	Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in an Nrf2-dependent pathway.	Hydrogen	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	102-106
32480174-3	2020	The modeling study revealed that compound 6 binds well to the binding pockets of PPARalpha and PPARdelta, which formed multiple hydrogen bonds with key residues related to the activation of PPARalpha and PPARdelta.	Hydrogen	128-136	peroxisome proliferator activated receptor alpha	Mus musculus	81-90
32480174-3	2020	The modeling study revealed that compound 6 binds well to the binding pockets of PPARalpha and PPARdelta, which formed multiple hydrogen bonds with key residues related to the activation of PPARalpha and PPARdelta.	Hydrogen	128-136	peroxisome proliferator activator receptor delta	Mus musculus	95-104
32480174-3	2020	The modeling study revealed that compound 6 binds well to the binding pockets of PPARalpha and PPARdelta, which formed multiple hydrogen bonds with key residues related to the activation of PPARalpha and PPARdelta.	Hydrogen	128-136	peroxisome proliferator activated receptor alpha	Mus musculus	190-199
32480174-3	2020	The modeling study revealed that compound 6 binds well to the binding pockets of PPARalpha and PPARdelta, which formed multiple hydrogen bonds with key residues related to the activation of PPARalpha and PPARdelta.	Hydrogen	128-136	peroxisome proliferator activator receptor delta	Mus musculus	204-213
32171830-8	2020	In-silico molecular docking depicts CNP interaction via hydrogen bonding between Ins and Hb through neutral; polar and neutral; nonpolar amino acids, respectively.	Hydrogen	56-64	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	36-39
32628490-0	2020	Unveiling the Role of Hydrogen Bonding and g -Tensor in the Interaction of Ru-Bis-DMSO with Amino Acid Residue and Human Serum Albumin.	Hydrogen	22-30	albumin	Homo sapiens	121-134
32415997-2	2020	1 J(15 N,H) coupling constants for enaminones and NH-forms of intramolecularly hydrogen bonded Schiff bases as model compounds for sp2 hybridized nitrogen atoms are evaluated using density functional theory (DFT) to find the optimal functionals and basis sets.	Hydrogen	79-87	Sp2 transcription factor	Homo sapiens	131-134
32775930-3	2020	Results show that with an increase of methane mole fraction in the hydrogen/methane system, the upper turning point (P 1-2, T 1-2) remains almost unchanged and the lower transition point (P 2-3, T 2-3) rotates counterclockwise around (P 1-2, T 1-2).	Hydrogen	67-75	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	117-129
32728168-3	2020	Here we show that the mutation alters and constrains the PrP backbone conformation preceding the PrP beta-sheet, stabilising PrP dimer interactions by increasing intermolecular hydrogen bonding.	Hydrogen	177-185	prion protein	Homo sapiens	57-60
32728168-3	2020	Here we show that the mutation alters and constrains the PrP backbone conformation preceding the PrP beta-sheet, stabilising PrP dimer interactions by increasing intermolecular hydrogen bonding.	Hydrogen	177-185	prion protein	Homo sapiens	97-100
32728168-3	2020	Here we show that the mutation alters and constrains the PrP backbone conformation preceding the PrP beta-sheet, stabilising PrP dimer interactions by increasing intermolecular hydrogen bonding.	Hydrogen	177-185	prion protein	Homo sapiens	97-100
32539372-7	2020	From the present FMO study, His41, His163, His164, and Glu166 were found to be the most important amino acid residues of Mpro in interacting with the inhibitor, mainly due to hydrogen bonding.	Hydrogen	175-183	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	121-125
32609521-4	2020	This process relies on two bifurcated hydrogen bonds that connect the beta2 and beta3 strands and eases the transition between the hydrogen bond pattern by which the central three-stranded beta-sheet in the two forms differ.	Hydrogen	38-46	ATPase H+ transporting V0 subunit a2	Homo sapiens	70-75
32609521-4	2020	This process relies on two bifurcated hydrogen bonds that connect the beta2 and beta3 strands and eases the transition between the hydrogen bond pattern by which the central three-stranded beta-sheet in the two forms differ.	Hydrogen	38-46	immunoglobulin kappa variable 2D-28	Homo sapiens	80-85
32609521-4	2020	This process relies on two bifurcated hydrogen bonds that connect the beta2 and beta3 strands and eases the transition between the hydrogen bond pattern by which the central three-stranded beta-sheet in the two forms differ.	Hydrogen	131-139	ATPase H+ transporting V0 subunit a2	Homo sapiens	70-75
32609521-4	2020	This process relies on two bifurcated hydrogen bonds that connect the beta2 and beta3 strands and eases the transition between the hydrogen bond pattern by which the central three-stranded beta-sheet in the two forms differ.	Hydrogen	131-139	immunoglobulin kappa variable 2D-28	Homo sapiens	80-85
32775930-3	2020	Results show that with an increase of methane mole fraction in the hydrogen/methane system, the upper turning point (P 1-2, T 1-2) remains almost unchanged and the lower transition point (P 2-3, T 2-3) rotates counterclockwise around (P 1-2, T 1-2).	Hydrogen	67-75	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	235-247
32333508-3	2020	Therefore, we have developed a set of novel TLR2 antagonists (1-9) based on the systematic variation of substructures, linker elements and the hydrogen-bonding pattern of the pyrogallol precursors by using chemically robust building blocks.	Hydrogen	143-151	toll like receptor 2	Homo sapiens	44-48
32496056-5	2020	Protein-ligand cocrystal structures clearly depicted hydrogen bond and hydrophobic interactions of 11k and 11l with hDHODH.	Hydrogen	53-61	dihydroorotate dehydrogenase (quinone)	Homo sapiens	116-122
32632429-0	2020	Hydrogen bonds and halogen bonds in complexes of carbones L C L as electron donors to HF and ClF, for L = CO, N2, HNC, PH3, and SH2.	Hydrogen	0-8	CLQTL1	Homo sapiens	93-96
32483595-4	2020	T-cell clones directed against the HLA*02:01-restricted MiHA HA-1H were isolated from HA-1Hneg/HLA-A*02:01pos and HA-1Hpos/HLA-A*02:01pos donors.	Hydrogen	64-66	major histocompatibility complex, class I, A	Homo sapiens	95-100
32483595-4	2020	T-cell clones directed against the HLA*02:01-restricted MiHA HA-1H were isolated from HA-1Hneg/HLA-A*02:01pos and HA-1Hpos/HLA-A*02:01pos donors.	Hydrogen	64-66	major histocompatibility complex, class I, A	Homo sapiens	123-128
32483595-9	2020	T-cell clones directed against the HLA*02:01-restricted MiHA HA-1H were isolated from HA-1Hneg/HLA-A*02:01pos and HA-1Hpos/HLA-A*02:01pos donors.	Hydrogen	64-66	major histocompatibility complex, class I, A	Homo sapiens	95-100
32483595-9	2020	T-cell clones directed against the HLA*02:01-restricted MiHA HA-1H were isolated from HA-1Hneg/HLA-A*02:01pos and HA-1Hpos/HLA-A*02:01pos donors.	Hydrogen	64-66	major histocompatibility complex, class I, A	Homo sapiens	123-128
32692306-5	2021	Various noncovalent interactions including hydrogen bonding, hydrophobic interactions, pi-sulfur and pi-pi interactions appear to be dominant in drug-Mpro complexes.	Hydrogen	43-51	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	150-154
32562617-3	2020	Here, we present how combining these techniques provides insight into the aggregation of the hexapeptide VEALYL (Val-Glu-Ala-Leu-Tyr-Leu), the B-chain residue 12-17 segment of insulin that forms amyloid fibrils (intermolecularly hydrogen-bonded beta-sheets) when the pH is lowered below 4.	Hydrogen	229-237	insulin	Homo sapiens	176-183
32684114-6	2021	The potency of DB02388 and Cobicistat is attributed to their abilities to form several hydrogen bonds with the essential amino acids inside the active site of Mpro.	Hydrogen	87-95	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	159-163
32348775-7	2020	Our results indicate that (1) chronic exposure of hydrogen gas is a simple, safe and promising therapeutic strategy to prevent memory loss in patients with sepsis and (2) acute H2 inhalation decreases neuroinflammation in memory-related areas and increases total nuclear factor E2-related factor 2 (Nrf2), a transcription factorthat regulates a vast group of antioxidant and inflammatory agents expression in these areas of septic animals.	Hydrogen	50-58	NFE2 like bZIP transcription factor 2	Homo sapiens	263-297
32348775-7	2020	Our results indicate that (1) chronic exposure of hydrogen gas is a simple, safe and promising therapeutic strategy to prevent memory loss in patients with sepsis and (2) acute H2 inhalation decreases neuroinflammation in memory-related areas and increases total nuclear factor E2-related factor 2 (Nrf2), a transcription factorthat regulates a vast group of antioxidant and inflammatory agents expression in these areas of septic animals.	Hydrogen	50-58	NFE2 like bZIP transcription factor 2	Homo sapiens	299-303
32651409-6	2020	In this study, we synthesized nano-graphene oxide (NGO) nanoparticles with GRPR-specific peptides AF750-6Ahx-Sta-BBN via hydrogen bond and pi-pi bonds (NGO-BBN-AF750), and investigated their receptor binding, cell uptake and internalization in HSC-3 cells.	Hydrogen	121-129	gastrin releasing peptide receptor	Homo sapiens	75-79
32650607-6	2020	The molecular docking results exhibited that the small molecule 13b is well accommodated by the bound region of Kelch-like ECH-associated protein 1 (Keap1)-Kelch and NRF2 through stable hydrogen bonds and hydrophobic interaction, which contributed to the enhancement of affinity and stability between the ligand and receptor.	Hydrogen	186-194	kelch like ECH associated protein 1	Homo sapiens	112-147
32650607-6	2020	The molecular docking results exhibited that the small molecule 13b is well accommodated by the bound region of Kelch-like ECH-associated protein 1 (Keap1)-Kelch and NRF2 through stable hydrogen bonds and hydrophobic interaction, which contributed to the enhancement of affinity and stability between the ligand and receptor.	Hydrogen	186-194	kelch like ECH associated protein 1	Homo sapiens	149-154
32650607-6	2020	The molecular docking results exhibited that the small molecule 13b is well accommodated by the bound region of Kelch-like ECH-associated protein 1 (Keap1)-Kelch and NRF2 through stable hydrogen bonds and hydrophobic interaction, which contributed to the enhancement of affinity and stability between the ligand and receptor.	Hydrogen	186-194	NFE2 like bZIP transcription factor 2	Homo sapiens	166-170
32687767-4	2021	Conservation and biochemical analyses showed that P525 is highly conserved; the mutation of proline to arginine at position 525 in FUS results in a notable increase in molecular weight, number of hydrogen bonds, and loss of hydrophobicity.	Hydrogen	196-204	FUS RNA binding protein	Homo sapiens	131-134
32574493-0	2020	Ice-like Vibrational Properties of Strong Hydrogen Bonds in Hydrated Lithium Nitrate.	Hydrogen	42-50	carboxylesterase 2	Homo sapiens	0-3
32574493-1	2020	The hydrogen bond network accounts for many of the extraordinary physical properties of liquid water and ice.	Hydrogen	4-12	carboxylesterase 2	Homo sapiens	105-108
32574493-4	2020	In this study, we find striking resemblance between the vibrational properties of three water molecules connected via strong hydrogen bonds in the trihydrate of LiNO3 and those of ordinary ice Ih.	Hydrogen	125-133	carboxylesterase 2	Homo sapiens	189-192
32361471-8	2020	The major degradation product (DP4) was isolated, and its structure was confirmed by HRMS and 1H NMR, 13C NMR, HMBC, DEPT 135 and Deuteriated NMR spectroscopy.	Hydrogen	94-96	transcription factor Dp family member 3	Homo sapiens	31-34
32428407-6	2020	We observe three avoided crossing regions in the dynamics: two along the isomerization coordinate (displaying pyramidalization and migration of an ethylenic hydrogen or phenyl group), and one DHP-like conical intersection along the cyclization coordinate.	Hydrogen	157-165	dihydropyrimidinase	Homo sapiens	192-195
32558559-5	2020	The narrow NMR signals of the Co(II), Fe(II), Fe(III), and V(III) derivatives provide resolved 13C,1H couplings.	Hydrogen	99-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-36
32169814-5	2020	Additionally, the molecular results indicated that PFDA bind with Val-A98 in the surface of Cu/Zn-SOD by a 3.11 A hydrogen bond driven by Van der Waals" force and hydrogen bonding force, which triggered the structural changes and decreased activity of Cu/Zn-SOD.	Hydrogen	114-122	superoxide dismutase 1, soluble	Mus musculus	92-101
32169814-5	2020	Additionally, the molecular results indicated that PFDA bind with Val-A98 in the surface of Cu/Zn-SOD by a 3.11 A hydrogen bond driven by Van der Waals" force and hydrogen bonding force, which triggered the structural changes and decreased activity of Cu/Zn-SOD.	Hydrogen	114-122	superoxide dismutase 1, soluble	Mus musculus	252-261
32169814-5	2020	Additionally, the molecular results indicated that PFDA bind with Val-A98 in the surface of Cu/Zn-SOD by a 3.11 A hydrogen bond driven by Van der Waals" force and hydrogen bonding force, which triggered the structural changes and decreased activity of Cu/Zn-SOD.	Hydrogen	163-171	superoxide dismutase 1, soluble	Mus musculus	92-101
32486643-5	2020	The host-guest interaction between mAzo and beta-CD as driving force for gelation was confirmed by 1H-NMR and 2D 1H NOESY spectra.	Hydrogen	99-101	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	44-51
32486643-5	2020	The host-guest interaction between mAzo and beta-CD as driving force for gelation was confirmed by 1H-NMR and 2D 1H NOESY spectra.	Hydrogen	113-115	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	44-51
32291646-5	2020	The adsorption mechanism of Pb(II) onto MOMC-NP revealed the formation of metal complexes with carboxyl, hydroxyl, and phosphate groups through ion exchange reactions and hydrogen bondings.	Hydrogen	171-179	submaxillary gland androgen regulated protein 3B	Homo sapiens	28-34
32483962-2	2020	Herein, we demonstrated that this goal can be achieved by fabricating a lanthanide functionalized hydrogen-bonded organic framework film (named as Eu@HOF-TCBP film).	Hydrogen	98-106	TIA1 cytotoxic granule associated RNA binding protein like 1	Homo sapiens	154-158
32291646-7	2020	At pH>pHpzc, the main Pb(II) existing species of Pb(II) and Pb(OH)+ combine with the carboxyl, hydroxyl, and phosphate functional groups via electrostatic interactions and hydrogen bonding.	Hydrogen	172-180	submaxillary gland androgen regulated protein 3B	Homo sapiens	22-28
32291646-7	2020	At pH>pHpzc, the main Pb(II) existing species of Pb(II) and Pb(OH)+ combine with the carboxyl, hydroxyl, and phosphate functional groups via electrostatic interactions and hydrogen bonding.	Hydrogen	172-180	submaxillary gland androgen regulated protein 3B	Homo sapiens	49-55
32537002-8	2020	Mechanistically, molecular hydrogen decreased TLR4 and MyD88 expression levels whilst also decreasing p65 and NF-kappaB inhibitor phosphorylation.	Hydrogen	27-35	toll-like receptor 4	Rattus norvegicus	46-50
32537002-8	2020	Mechanistically, molecular hydrogen decreased TLR4 and MyD88 expression levels whilst also decreasing p65 and NF-kappaB inhibitor phosphorylation.	Hydrogen	27-35	synaptotagmin 1	Rattus norvegicus	102-105
32537002-9	2020	In conclusion, molecular hydrogen exerted therapeutic effects against T2DM by improving hyperglycemia and inhibiting oxidative stress through mechanisms that are associated with the TLR4/MyD88/NF-kappaB signaling pathway.	Hydrogen	25-33	toll-like receptor 4	Rattus norvegicus	182-186
32432582-3	2020	Natural polyphenols can match the potential toughening sites in our previously reported PEG-lysozyme (LZM) hydrogel because polyphenols have unique structural units including a hydroxyl group and an aromatic ring that can interact with PEG via hydrogen bonding and form hydrophobic interactions with LZM.	Hydrogen	244-252	lysozyme	Homo sapiens	88-100
32344252-7	2020	The most common effect observed was that of the agonistic activity of ERalpha, with the molecular docking analysis further indicating that hydrogen bonding and hydrophobic interactions may stabilize the interaction between PHCZs and the estrogen receptor binding pocket.	Hydrogen	139-147	estrogen receptor 1	Homo sapiens	70-77
32344252-7	2020	The most common effect observed was that of the agonistic activity of ERalpha, with the molecular docking analysis further indicating that hydrogen bonding and hydrophobic interactions may stabilize the interaction between PHCZs and the estrogen receptor binding pocket.	Hydrogen	139-147	estrogen receptor 1	Homo sapiens	237-254
31402760-4	2020	Among the desired compounds, 1h shares the highest inhibitory activity (IC50 = 1.34 muM) against PTP-MEG2.	Hydrogen	29-31	latexin	Homo sapiens	84-87
32572254-6	2020	When the lower gate is closed in nanodisc-reconstituted TRPV3, the S6 helix adopts the pi-helical conformation without agonist- or heat-sensitization, potentially stabilized by putative intra-subunit hydrogen bonds and lipid binding.	Hydrogen	200-208	transient receptor potential cation channel, subfamily V, member 3	Mus musculus	56-61
32714406-13	2020	The 6"-hydroxyl and 6""-hydroxyl on the 3-glycosyl of ginsenoside Rg3 are prone to form hydrogen bonds (Lys151 and Lys221) with the active sites of EpCAM ligand binding domain.	Hydrogen	88-96	epithelial cell adhesion molecule	Homo sapiens	148-153
32714406-15	2020	The formation of hydrogen bonds plays an important role in binding of ginsenoside Rg3 and ginsenoside Rh2 to EpCAM, as well as the stability of EpCAM conformation.	Hydrogen	17-25	epithelial cell adhesion molecule	Homo sapiens	109-114
32714406-15	2020	The formation of hydrogen bonds plays an important role in binding of ginsenoside Rg3 and ginsenoside Rh2 to EpCAM, as well as the stability of EpCAM conformation.	Hydrogen	17-25	epithelial cell adhesion molecule	Homo sapiens	144-149
32027458-3	2020	X-ray structure elucidation revealed hydrogen-bridged linear [CN(HCN) 2 ] - and Y-shaped [CN(HCN) 3 ] - molecular ions in the crystal.	Hydrogen	37-45	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	65-71
32189464-2	2020	A neutral cobalt(II) complex, [Co II (COO-terpy) 2 ] 4H 2 O ( 1 4H 2 O ), stably formed cavities generated via pi-pi stacking motifs and hydrogen bond networks, resulted in the accommodation of four water molecules.	Hydrogen	137-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
31463747-3	2020	The thermodynamic parameters indicated that CARB could interact spontaneously with CAT to form a complex mainly by van der Waals" interactions and hydrogen bonds.	Hydrogen	147-155	catalase	Homo sapiens	83-86
32350570-0	2020	Hydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation.	Hydrogen	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	56-60
32350570-15	2020	Hydrogen increased Nrf2 expression and inhibited the SAE-induced expression of NLRP3, caspase-1, cytokines IL-1beta and IL-18, neuronal apoptosis, and mitochondrial dysfunction in WT mice but not Nrf2 KO mice.	Hydrogen	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23
32350570-15	2020	Hydrogen increased Nrf2 expression and inhibited the SAE-induced expression of NLRP3, caspase-1, cytokines IL-1beta and IL-18, neuronal apoptosis, and mitochondrial dysfunction in WT mice but not Nrf2 KO mice.	Hydrogen	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	196-200
32350570-17	2020	Hydrogen alleviated inflammation, neuronal apoptosis and mitochondrial dysfunction via inhibiting Nrf2-mediated NLRP3 pathway.	Hydrogen	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	98-102
32361189-10	2020	Moreover, the decreased expression of Bcl-xl and Bcl-2 and the increased expression of Bax protein were also blocked by hydrogen treatment.	Hydrogen	120-128	B cell leukemia/lymphoma 2	Mus musculus	49-54
32501687-8	2020	These observations are consistent with a model in which the assembly of Abeta oligomers is driven by hydrogen bonding and hydrophobic packing of the residues from the central and C-terminal regions, with the N-terminus of Abeta accommodated by the oligomers as an unstructured tail.	Hydrogen	101-109	amyloid beta precursor protein	Homo sapiens	72-77
32311663-6	2020	Our results showed that, alpha-MMC bound to LRP1 stably at the amino acid residues 1-20, at which 8 residues formed 21 hydrogen bonds with 15 residues of CR56 and 10 residues formed 15 hydrogen bonds with 12 residues of CR17.	Hydrogen	119-127	LDL receptor related protein 1	Homo sapiens	44-48
32311663-6	2020	Our results showed that, alpha-MMC bound to LRP1 stably at the amino acid residues 1-20, at which 8 residues formed 21 hydrogen bonds with 15 residues of CR56 and 10 residues formed 15 hydrogen bonds with 12 residues of CR17.	Hydrogen	185-193	LDL receptor related protein 1	Homo sapiens	44-48
32657160-5	2020	Residue-based free energy decomposition method was wielded to unveil contributions of independent residues to inhibitor bindings and the data signify that hydrogen bonding interactions and hydrophobic interactions are decisive factors affecting bindings of inhibitors to BRD4(1).	Hydrogen	155-163	bromodomain containing 4	Homo sapiens	271-275
32884210-2	2020	We report the optimal binding features (binding energy, interacting residues, inter atomic hydrogen bonding patterns) of 11 amino-pyrimidine derivatives with Jnk for further consideration.	Hydrogen	91-99	mitogen-activated protein kinase 8	Homo sapiens	158-161
32432582-3	2020	Natural polyphenols can match the potential toughening sites in our previously reported PEG-lysozyme (LZM) hydrogel because polyphenols have unique structural units including a hydroxyl group and an aromatic ring that can interact with PEG via hydrogen bonding and form hydrophobic interactions with LZM.	Hydrogen	244-252	lysozyme	Homo sapiens	102-105
32147343-2	2020	In this work, BBH was solubilized with beta-cyclodextrin (beta-CD) in aqueous solution through formation of the BBH/beta-CD inclusion complex (IC), which was confirmed by the combination of different techniques including FT-IR, XRD, DSC, 1H NMR and 1H NOESY.	Hydrogen	238-240	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	58-65
32586261-7	2021	RESULTS: The discovered lead compound achieved several hydrogen bonds with the primary residues found in the active site of HER2, such as; Met801, Gln99, Lys753, and Thr862 with a computational affinity - 13.45 kcal/mol.	Hydrogen	55-63	erb-b2 receptor tyrosine kinase 2	Homo sapiens	124-128
32147343-2	2020	In this work, BBH was solubilized with beta-cyclodextrin (beta-CD) in aqueous solution through formation of the BBH/beta-CD inclusion complex (IC), which was confirmed by the combination of different techniques including FT-IR, XRD, DSC, 1H NMR and 1H NOESY.	Hydrogen	238-240	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	116-123
32147343-2	2020	In this work, BBH was solubilized with beta-cyclodextrin (beta-CD) in aqueous solution through formation of the BBH/beta-CD inclusion complex (IC), which was confirmed by the combination of different techniques including FT-IR, XRD, DSC, 1H NMR and 1H NOESY.	Hydrogen	249-251	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	58-65
32147343-2	2020	In this work, BBH was solubilized with beta-cyclodextrin (beta-CD) in aqueous solution through formation of the BBH/beta-CD inclusion complex (IC), which was confirmed by the combination of different techniques including FT-IR, XRD, DSC, 1H NMR and 1H NOESY.	Hydrogen	249-251	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	116-123
32566032-1	2020	Stability constants for the inclusion complexes of cyclohexylphthalimide 2 and adamantylphthalimide 3 with beta-cyclodextrin (beta-CD) were determined by 1H NMR titration, K = 190 +- 50 M-1, and K = 2600 +- 600 M-1, respectively.	Hydrogen	154-156	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	126-133
32566032-3	2020	The formation of ternary complexes with acrylonitrile (AN) and 2@beta-CD or 3@beta-CD was also essayed by 1H NMR.	Hydrogen	106-108	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	78-85
32375478-3	2020	Further identification of allosteric inhibition mechanism reveal that the covalent binding of a fragment of 214 will result in the movement of C128 and the dissociation of helix H4 (123-128), which in turn allows S123 to more easily form new hydrogen-bonds with K71 and D74 in helix H3 (69-72), thereby inhibiting FBPase activity.	Hydrogen	242-250	keratin 71	Homo sapiens	262-265
32520690-9	2021	Molecular docking model for the most active molecule exhibited promising bindings with AChE and BChE"s active site pertained to hydrophobic hydrogen bonds and positive ionizable interactions.	Hydrogen	140-148	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-91
32532135-12	2020	Furthermore, the number of hydrogen bonds of dog PrP with the Glu182 and Gly182 alleles were predicted to be less than those with the Asp182 allele.	Hydrogen	27-35	prion protein	Canis lupus familiaris	49-52
32167640-6	2020	Molecular simulations indicated that the low FBR performance of beta-HS results from what we term "dual hydrogen bonding hydration", wherein both the backbone amide groups and the side chain hydroxyl groups of beta-HS undergo hydration.	Hydrogen	104-112	alpha 2-HS glycoprotein	Homo sapiens	64-71
32587471-0	2020	Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal Ischemia/Reperfusion Injury in Rats through NF-kappaB/NLRP3 Pathway.	Hydrogen	58-66	NLR family, pyrin domain containing 3	Rattus norvegicus	154-159
32167640-6	2020	Molecular simulations indicated that the low FBR performance of beta-HS results from what we term "dual hydrogen bonding hydration", wherein both the backbone amide groups and the side chain hydroxyl groups of beta-HS undergo hydration.	Hydrogen	104-112	alpha 2-HS glycoprotein	Homo sapiens	210-217
32370868-0	2020	Hydrogen/deuterium exchange mass spectrometry with improved electrochemical reduction enables comprehensive epitope mapping of a therapeutic antibody to the cysteine-knot containing vascular endothelial growth factor.	Hydrogen	0-8	vascular endothelial growth factor A	Homo sapiens	182-216
31558672-3	2020	In the present study, Hydrogen- deuterium exchange mass spectrometry was employed to gain insight into the FVIII binding region on Von Willebrand Factor.	Hydrogen	22-30	von Willebrand factor	Homo sapiens	131-152
32508225-6	2021	The molecular docking studied showed that xylotriose showed better binding interactions to XylA than xylobiose and xylobiose showed better binding interaction to XylB than xylotriose with ideal root mean square deviation (RMS), minimum binding energy (kcal/mol), hydrogen bonding and weak interactions.	Hydrogen	263-271	xylulokinase	Homo sapiens	162-166
32499574-6	2020	We observed conformational changes of the conserved loop2-loop4 (L2-L4 loops) in MCU NTDS92E, NTDD119A, and NTDS92p due to the breakage of the S92-D119 hydrogen bond.	Hydrogen	152-160	mitochondrial calcium uniporter	Homo sapiens	81-84
32292127-0	2020	Hydrogen improves cell viability partly through inhibition of autophagy and activation of PI3K/Akt/GSK3beta signal pathway in a microvascular endothelial cell model of traumatic brain injury.	Hydrogen	0-8	AKT serine/threonine kinase 1	Homo sapiens	95-98
32073192-9	2020	Molecular docking analysis demonstrates the molecular shifts in hydrogen and ionic bonds and Van der waals bonding properties which have further caused the differences in the binding energy of LDLR-LDLRAP1 proteins.	Hydrogen	64-72	low density lipoprotein receptor adaptor protein 1	Homo sapiens	198-205
31315508-11	2020	ITC results revealed that BSA-PRX binding involves a combination of electrostatic, hydrophobic and hydrogen interactions.	Hydrogen	99-107	albumin	Homo sapiens	26-29
32035313-5	2020	The aim and natural bond orbital analysis identified key contribution of individual hydrogen/halogen bonds that contribute for the binding strength through stabilization energy, rho and  2rho values.	Hydrogen	84-92	rhodopsin	Homo sapiens	178-188
32550805-7	2020	Results have shown that TLM significantly interacts with the binding site-1 of HSA utilizing strong hydrogen bonding with Glu292, and Lys195 residues.	Hydrogen	100-108	albumin	Homo sapiens	79-82
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	126-134	AKT serine/threonine kinase 1	Homo sapiens	38-41
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	126-134	AKT serine/threonine kinase 1	Homo sapiens	216-219
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	126-134	AKT serine/threonine kinase 1	Homo sapiens	216-219
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	324-332	AKT serine/threonine kinase 1	Homo sapiens	38-41
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	324-332	AKT serine/threonine kinase 1	Homo sapiens	216-219
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	324-332	AKT serine/threonine kinase 1	Homo sapiens	216-219
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	324-332	AKT serine/threonine kinase 1	Homo sapiens	38-41
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	324-332	AKT serine/threonine kinase 1	Homo sapiens	216-219
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	324-332	AKT serine/threonine kinase 1	Homo sapiens	216-219
32018136-4	2020	Conjugation disrupted the hydrogen bonds of SPI as indicated by the lowest band intensity at 1646, 1533 and 3300-3450 cm-1 on FTIR spectra.	Hydrogen	26-34	chromogranin A	Homo sapiens	44-47
32450796-0	2020	Probing contacts of inhibitor locked in transition states in the catalytic triad of DENV2 type serine protease and its mutants by 1H, 19F and 15 N NMR spectroscopy.	Hydrogen	130-132	coagulation factor II, thrombin	Homo sapiens	95-110
31410875-0	2020	Highlights of C (sp2 )-H hydrogen isotope Exchange Reactions.	Hydrogen	25-33	Sp2 transcription factor	Homo sapiens	14-20
31410875-1	2020	The highlights of C (sp2 )-H hydrogen isotope exchange (HIE) methods developed over the past ten years are summarized in this review.	Hydrogen	29-37	Sp2 transcription factor	Homo sapiens	18-24
32450796-3	2020	In this study 1H, 19F and 15 N NMR spectroscopy has been used to probe the interaction contacts of inhibitors locked in transition states of the catalytic triad of a serine protease.	Hydrogen	14-16	coagulation factor II, thrombin	Homo sapiens	166-181
32457871-3	2020	In this study, the Y220C-PhiKan5196 complex of p53 protein was adopted as a model, and the functions of three water molecules that formed hydrogen bonds with halogen atoms were analyzed by the simulation method governed by the hybrid quantum mechanical/molecular mechanical molecular dynamics.	Hydrogen	138-146	tumor protein p53	Homo sapiens	47-50
32455924-4	2020	The 1H-NMR profiles highlighted a similar go and return pattern in the metabolism of the BRAF, NRAS, and cKIT mutated cell lines.	Hydrogen	4-6	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	89-93
32455924-4	2020	The 1H-NMR profiles highlighted a similar go and return pattern in the metabolism of the BRAF, NRAS, and cKIT mutated cell lines.	Hydrogen	4-6	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	105-109
32438322-4	2020	Of note, in pCtid-UAA-beta2m-2, a unique hydrogen bond network formed in the bottom of the peptide-binding groove (PBG) led to alpha2-helix drift, ultimately leading to structural changes in the PBG.	Hydrogen	41-49	glycoprotein hormone subunit alpha 2	Homo sapiens	127-133
32297632-10	2020	The AP-site is stabilized by an extensive hydrogen bond network in the MBD4 catalytic site, highlighting the role of MBD4 in protecting the genotoxic AP-site.	Hydrogen	42-50	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	71-75
32297632-10	2020	The AP-site is stabilized by an extensive hydrogen bond network in the MBD4 catalytic site, highlighting the role of MBD4 in protecting the genotoxic AP-site.	Hydrogen	42-50	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	117-121
32113536-3	2020	The hydrophobic and hydrogen-bond interactions between the amino acid residues of HSA and TPE-IL lead to the spontaneous and energetically favorable docking of TPE-IL molecules in the hydrophobic subdomain of HSA, inducing the significant fluorescence enhancement of this sensor.	Hydrogen	20-28	albumin	Homo sapiens	82-85
32113536-3	2020	The hydrophobic and hydrogen-bond interactions between the amino acid residues of HSA and TPE-IL lead to the spontaneous and energetically favorable docking of TPE-IL molecules in the hydrophobic subdomain of HSA, inducing the significant fluorescence enhancement of this sensor.	Hydrogen	20-28	albumin	Homo sapiens	209-212
33463291-2	2020	They are made up of protofilaments composed of amyloid beta (Abeta) peptides that are held together with extraordinary stability by a network of tight steric zippers and axial hydrogen bonds.	Hydrogen	176-184	amyloid beta precursor protein	Homo sapiens	47-59
33463291-2	2020	They are made up of protofilaments composed of amyloid beta (Abeta) peptides that are held together with extraordinary stability by a network of tight steric zippers and axial hydrogen bonds.	Hydrogen	176-184	amyloid beta precursor protein	Homo sapiens	61-66
32422931-6	2020	Molecular docking analysis showed that these two peptides formed hydrophobic interactions and hydrogen bonds with epidermal growth factor receptor (EGFR) to activate the EGFR-signaling pathway, which may explain their bioactivity.	Hydrogen	94-102	epidermal growth factor receptor	Bos taurus	114-146
32422931-6	2020	Molecular docking analysis showed that these two peptides formed hydrophobic interactions and hydrogen bonds with epidermal growth factor receptor (EGFR) to activate the EGFR-signaling pathway, which may explain their bioactivity.	Hydrogen	94-102	epidermal growth factor receptor	Bos taurus	148-152
32422931-6	2020	Molecular docking analysis showed that these two peptides formed hydrophobic interactions and hydrogen bonds with epidermal growth factor receptor (EGFR) to activate the EGFR-signaling pathway, which may explain their bioactivity.	Hydrogen	94-102	epidermal growth factor receptor	Bos taurus	170-174
32355040-6	2020	Crystallographic analysis of the DAPK1-purpurin complex revealed that the formation of a hydrogen-bond network is likely to contribute to the favorable enthalpic changes and that stabilization of the glycine-rich loop may cause less favorable entropic changes.	Hydrogen	89-97	death associated protein kinase 1	Homo sapiens	33-38
32068943-4	2020	Herein, we report that arene cation radicals generated via organic photoredox catalysis engage in formal C-H functionalization reactions with diazoacetate derivatives, furnishing sp 2 -sp 3 coupled products with moderate to good regioselectivity.	Hydrogen	105-108	Sp2 transcription factor	Homo sapiens	179-183
32068943-4	2020	Herein, we report that arene cation radicals generated via organic photoredox catalysis engage in formal C-H functionalization reactions with diazoacetate derivatives, furnishing sp 2 -sp 3 coupled products with moderate to good regioselectivity.	Hydrogen	105-108	Sp3 transcription factor	Homo sapiens	185-189
32139324-4	2020	Compounds 1e and 1h were identified as lead compounds which displayed almost 3-4 times more potent inhibition of EGFR and HER2 than the approved drug lapatinib.	Hydrogen	17-19	epidermal growth factor receptor	Homo sapiens	113-117
32125649-5	2020	Molecular docking simulation showed that allantoin promoted the phosphorylation (activation) of adenosine monophosphate-activated kinase (AMPK) by lowering the substrate free energy of binding (FEB) and induced the formation of an additional hydrogen bond between Val184 and the substrate AMP.	Hydrogen	242-250	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	96-136
32125649-5	2020	Molecular docking simulation showed that allantoin promoted the phosphorylation (activation) of adenosine monophosphate-activated kinase (AMPK) by lowering the substrate free energy of binding (FEB) and induced the formation of an additional hydrogen bond between Val184 and the substrate AMP.	Hydrogen	242-250	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	138-142
32139324-4	2020	Compounds 1e and 1h were identified as lead compounds which displayed almost 3-4 times more potent inhibition of EGFR and HER2 than the approved drug lapatinib.	Hydrogen	17-19	erb-b2 receptor tyrosine kinase 2	Homo sapiens	122-126
32160414-1	2020	Thioredoxin (Trx) is a hydrogen acceptor of ribonucleotide reductase, and a regulator of some enzymes and receptors.	Hydrogen	23-31	thioredoxin 1	Rattus norvegicus	0-11
32201191-6	2020	The accessibility of each site of tebufenozide to the reaction center of CYP enzymes and the susceptibility of each hydrogen atom for metabolism by CYP enzymes were evaluated by a docking simulation and hydrogen atom abstraction energy estimation at the density functional theory level, respectively.	Hydrogen	116-124	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	148-151
32201191-6	2020	The accessibility of each site of tebufenozide to the reaction center of CYP enzymes and the susceptibility of each hydrogen atom for metabolism by CYP enzymes were evaluated by a docking simulation and hydrogen atom abstraction energy estimation at the density functional theory level, respectively.	Hydrogen	203-211	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	73-76
32201191-6	2020	The accessibility of each site of tebufenozide to the reaction center of CYP enzymes and the susceptibility of each hydrogen atom for metabolism by CYP enzymes were evaluated by a docking simulation and hydrogen atom abstraction energy estimation at the density functional theory level, respectively.	Hydrogen	203-211	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	148-151
32201191-8	2020	In addition, the production rate of the metabolites by CYP3A4 was quantitively analyzed by frequency based on docking simulation and hydrogen atom abstraction energy using the classical QSAR approach.	Hydrogen	133-141	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	55-61
32220668-4	2020	Characterization of the [Dmim][BF4]-alpha-CD inclusion complex (IC) by 1H NMR spectroscopy provided information about the complexation among the [Dmim][BF4] and alpha-CD molecules and the structure of the ICs.	Hydrogen	71-73	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	36-44
32160414-1	2020	Thioredoxin (Trx) is a hydrogen acceptor of ribonucleotide reductase, and a regulator of some enzymes and receptors.	Hydrogen	23-31	thioredoxin 1	Rattus norvegicus	13-16
32040235-0	2020	Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway.	Hydrogen	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	83-87
31743711-7	2020	P13 can spontaneously bind with thrombin exosite 1 in the form of 1:1 mainly through hydrogen bonding and van der Waals force.	Hydrogen	85-93	coagulation factor II, thrombin	Homo sapiens	32-40
32150253-8	2020	Three-dimensional modeling predicted the p.Ser448Pro variant to disrupt a hydrogen bond interaction within the CaSR extracellular domain.	Hydrogen	74-82	calcium sensing receptor	Homo sapiens	111-115
31984539-7	2020	After DATS treatment, H2 S quickly permeated cell membranes and activated NF-kappaBeta/p65 signaling pathway in KTC-1 cells.	Hydrogen	22-24	nuclear factor kappa B subunit 1	Homo sapiens	74-86
32120161-4	2020	All Co(III) complexes were characterized by multinuclear NMR spectroscopy (1H, 13C and 59Co NMR), FT-IR, mass spectrometry and HPLC.	Hydrogen	75-77	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	4-11
32311236-3	2020	Owing to its highly electroactive sites with numerous nanoporous networks and plentiful oxygen vacancies, the optimal O-Co0.5 Mo0.5 Se2 could catalyze the hydrogen evolution reaction and oxygen evolution reaction effectively with a low overpotential of  102 and 189 mV, at a current density of 10 mA cm-2 , respectively, and exceptional durability.	Hydrogen	155-163	fucosyltransferase 2	Homo sapiens	132-135
32399094-8	2020	The number of hydrogen bonds between statins and amino acid residues of Mpro were 7, 4, and 3 for rosuvastatin, pravastatin, and atorvastatin, respectively, while other statins had two hydrogen bonds.	Hydrogen	14-22	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	72-76
32227118-1	2020	The sodium-hydrogen exchanger isoform 3 (NHE3, SLC9A3) is abundantly expressed in the gastrointestinal tract and is proposed to play essential roles in Na+ and fluid absorption as well as acid-base homeostasis.	Hydrogen	11-19	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	41-45
32227118-1	2020	The sodium-hydrogen exchanger isoform 3 (NHE3, SLC9A3) is abundantly expressed in the gastrointestinal tract and is proposed to play essential roles in Na+ and fluid absorption as well as acid-base homeostasis.	Hydrogen	11-19	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	47-53
32399094-8	2020	The number of hydrogen bonds between statins and amino acid residues of Mpro were 7, 4, and 3 for rosuvastatin, pravastatin, and atorvastatin, respectively, while other statins had two hydrogen bonds.	Hydrogen	185-193	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	72-76
32377304-3	2020	Cytochrome c interacts with lipid membranes by electrostatic interactions, hydrogen bonds, and hydrophobic effects.	Hydrogen	75-83	cytochrome c, somatic	Homo sapiens	0-12
32233362-3	2020	However, direct use of arenes and alkanes via a twofold oxidative C-H bond activation strategy to access chemoselective C(sp2)-C(sp3) cross-couplings is highly challenging due to the low reactivity of carbon-hydrogen (C-H) bonds and the difficulty in suppressing side reactions such as homocouplings.	Hydrogen	208-216	Sp2 transcription factor	Homo sapiens	120-125
32202581-6	2020	Additionally, we found that compared with Fc-FY, the better inhibitory effect of Fc-FF at concentration below 400 microM was mainly resulted from the difference in pi-pi interaction and hydrogen bonds between Fc-peptides and insulin, according to molecular dynamics analysis.	Hydrogen	186-194	insulin	Homo sapiens	225-232
32250625-1	2020	Gas hydrate forms when the hydrogen bonded crystal structure of water entraps small-sized gas molecules at relatively low temperature and high pressure.	Hydrogen	27-35	PAXIP1 associated glutamate rich protein 1	Homo sapiens	0-3
32250625-1	2020	Gas hydrate forms when the hydrogen bonded crystal structure of water entraps small-sized gas molecules at relatively low temperature and high pressure.	Hydrogen	27-35	PAXIP1 associated glutamate rich protein 1	Homo sapiens	90-93
32239053-4	2020	The MD simulations indicate that the dynamic behavior of PN is governed by hydrogen bonds between the membrane phosphate fragments and the tip.	Hydrogen	75-83	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	57-59
32207949-8	2020	However, it unfolds in water medium at 450 K. It is found that the hydrogen bonding interactions between c-kit G-quadruplex DNA and reline play a key role in the stabilization of the G-quadruplex DNA even at high temperature.	Hydrogen	67-75	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	105-110
31958607-11	2020	Therefore, ZnCdO2 monolayer and CdO monolayer (with tensile strain larger than 2%) is a promising candidate for the water splitting to produce hydrogen under the irradiation of the solar light.	Hydrogen	143-151	cell adhesion associated, oncogene regulated	Homo sapiens	13-16
32373627-8	2020	In addition, the H862 residue in PARP-1 has stronger binding free energy than H428 in PARP-2, which is due to shorter distance and stronger hydrogen bonds.	Hydrogen	140-148	poly(ADP-ribose) polymerase 1	Homo sapiens	33-39
32373627-8	2020	In addition, the H862 residue in PARP-1 has stronger binding free energy than H428 in PARP-2, which is due to shorter distance and stronger hydrogen bonds.	Hydrogen	140-148	poly(ADP-ribose) polymerase 2	Homo sapiens	86-92
32337406-9	2020	The simulation results highlight the importance of hydrogen bonds and the salt bridge between Lys94 of MDM2 and Glu17 of p53 in the stability of the p53-MDM2 complex.	Hydrogen	51-59	tumor protein p53	Homo sapiens	149-152
32033752-6	2020	The protein includes a beta-sheet network connected by hydrogen bonds.	Hydrogen	55-63	amyloid beta precursor protein	Homo sapiens	21-27
32175547-9	2020	ZIF-8 prepared using terephthalic acid shows high catalytic activity with a hydrogen rate of 2333 mLH2 min-1 gcat-1 (8046 mLH2 min-1 gZn-1).	Hydrogen	76-84	CD59 molecule (CD59 blood group)	Homo sapiens	127-138
32215417-6	2020	Herein, we provide a detailed and systematic description of the decomposition for unit-cell alpha-RDX and epsilon-CL-20 under increased temperature, which can be summarized as C3H6O6N6 (RDX)   NO + HNO + H2 + CO2 + HCHO + HNCN + N2O and C6H6O12N12 (CL-20)   NO + HONO + 5HCN + CO2 + N2O + 3NO2.	Hydrogen	204-206	epithelial membrane protein 1	Homo sapiens	114-119
32141290-4	2020	A mechanistic study suggests that the facile complexation of porphyrins with amphiphilic beta-CD via hydrogen bonding interaction greatly improves the water insolubility and the aggregation-caused deficient ECL of liposoluble porphyrins in aqueous solution.	Hydrogen	101-109	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	89-96
31958607-1	2020	ZnO monolayer possesses band structure matching the conditions of water splitting for hydrogen generation but cannot well response to the visible light, while CdO one, contrariwise, have obvious optical absorption in the visible light range but no satisfactory band edges for the water splitting to produce hydrogen.	Hydrogen	307-315	cell adhesion associated, oncogene regulated	Homo sapiens	159-162
32105440-4	2020	The cocrystal structural information provides insights into the binding pattern of 3e in the PDE10A catalytic domain to highlight the key role of the halogen and hydrogen bonds toward Tyr524 and Tyr693, respectively, thereby resulting in high selectivity against other PDEs.	Hydrogen	162-170	phosphodiesterase 10A	Homo sapiens	93-99
32097007-4	2020	At microscopic level, Molecular Dynamics simulations highlight the complex interplay of hydrogen bonding mediated hydrophilic interactions and hydrophobic forces mitigation occurring between beta-CD and Reline components, leading to energetically favourable beta-CD solvation.	Hydrogen	88-96	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	258-265
32105440-4	2020	The cocrystal structural information provides insights into the binding pattern of 3e in the PDE10A catalytic domain to highlight the key role of the halogen and hydrogen bonds toward Tyr524 and Tyr693, respectively, thereby resulting in high selectivity against other PDEs.	Hydrogen	162-170	phosphodiesterase 10A	Homo sapiens	269-273
32229715-8	2020	Molecules A and B of RTF generate respective helical assemblies across the crystallographic 21-screw axis through classical N-H...O aand O-H...O hydrogen bonds supplemented by C-H...O contacts.	Hydrogen	145-153	ATPase H+ transporting V0 subunit a2	Homo sapiens	21-24
32045054-7	2020	Molecular docking of the designed compounds in the VEGFR-2 and FGFR-1 active sites showed the accommodation of the 2-phenylbenzothiazole moiety, as reported, in the hinge region of the receptor tyrosine kinase (RTK)-binding site, while the amide moiety is involved in hydrogen bond interactions with the key amino acids in the gate area; this in turn directs the aryl group to the hydrophobic allosteric back pocket of the RTKs in a type II-like binding mode.	Hydrogen	268-276	fibroblast growth factor receptor 1	Homo sapiens	63-69
31505122-10	2020	Gut barrier permeability and circulating cytokine concentrations were also greater(p&lt;0.05) following HYP exercise, where I-FABP was shown increased at Post(+68%) and IL-1Ra at 1h-Post(+266%).	Hydrogen	179-181	fatty acid binding protein 2	Homo sapiens	124-130
32086051-7	2020	By forming hydrogen bonds with Tyr48 and His110 of the protein from ALR2 (PDB ID: 2FZD), the compounds 6g and 6e interrupt the proton donation mechanism, which is necessary for the catalytic activity of ALR2.	Hydrogen	11-19	aldo-keto reductase family 1 member B	Homo sapiens	68-72
32120077-3	2020	In this paper, HDAC6 inhibitors with diverse structures were used to generate the pharmacophore model by ligand-based method, which contained two hydrogen bond acceptors and two hydrophobic groups.	Hydrogen	146-154	histone deacetylase 6	Homo sapiens	15-20
32086051-7	2020	By forming hydrogen bonds with Tyr48 and His110 of the protein from ALR2 (PDB ID: 2FZD), the compounds 6g and 6e interrupt the proton donation mechanism, which is necessary for the catalytic activity of ALR2.	Hydrogen	11-19	aldo-keto reductase family 1 member B	Homo sapiens	203-207
32244587-7	2020	In addition, mutagenesis experiments showed that the residue His390 is the anchor residue for the binding to the Dap-type PGN and forms a hydrogen bond with MurNAc rather than meso-Dap, which interacts with the anchor residue Arg413 of PGRP-LCx in Drosophila.	Hydrogen	138-146	dacapo	Drosophila melanogaster	113-116
32058932-13	2020	In both animal and cell research, hydrogen reduced TNF-alpha, IL-6 and HMGB1 levels and M1 polarization, but increased IL-10 and TGF-beta levels and M2 polarization.	Hydrogen	34-42	tumor necrosis factor	Mus musculus	51-60
32058932-13	2020	In both animal and cell research, hydrogen reduced TNF-alpha, IL-6 and HMGB1 levels and M1 polarization, but increased IL-10 and TGF-beta levels and M2 polarization.	Hydrogen	34-42	interleukin 6	Mus musculus	62-66
32058932-13	2020	In both animal and cell research, hydrogen reduced TNF-alpha, IL-6 and HMGB1 levels and M1 polarization, but increased IL-10 and TGF-beta levels and M2 polarization.	Hydrogen	34-42	interleukin 10	Mus musculus	119-124
32489564-0	2020	Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine beta-synthase (CBS) after cerebral ischemia- reperfusion in rats.	Hydrogen	0-8	cystathionine beta synthase	Rattus norvegicus	102-129
32489564-0	2020	Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine beta-synthase (CBS) after cerebral ischemia- reperfusion in rats.	Hydrogen	0-8	cystathionine beta synthase	Rattus norvegicus	131-134
32489564-5	2020	Results: Our results showed that hydrogen up-regulated H2S levels via promoting the expression of CBS in the hippocampus, and its treatment alleviated oxidative stress via activating the expression of Nrf2 and HO-1, and then cell apoptosis reduced, furthermore, brain function improved by down-regulating the levels of S100-betaand NSE.	Hydrogen	33-41	cystathionine beta synthase	Rattus norvegicus	98-101
32489564-5	2020	Results: Our results showed that hydrogen up-regulated H2S levels via promoting the expression of CBS in the hippocampus, and its treatment alleviated oxidative stress via activating the expression of Nrf2 and HO-1, and then cell apoptosis reduced, furthermore, brain function improved by down-regulating the levels of S100-betaand NSE.	Hydrogen	33-41	NFE2 like bZIP transcription factor 2	Rattus norvegicus	201-205
32489564-6	2020	Conclusion: This study showed that hydrogen-rich saline ameliorates cell injury through up-regulating the expression of CBS in the hippocampus after cerebral ischemia reperfusion (I/R) in rats, this provides new experimental evidence for the treatment of stroke with hydrogen saline.	Hydrogen	35-43	cystathionine beta synthase	Rattus norvegicus	120-123
31793068-0	2020	PARP1 hinders histone H2B occupancy at the NFATc1 promoter to restrain osteoclast differentiation.	Hydrogen	22-25	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	43-49
31793068-5	2020	These unbiased approaches in conjunction with site-directed mutagenesis studies revealed that PARP1 inhibited NFATc1 expression and OC formation by ADP-ribosylating histone H2B at serine 7 and decreasing the occupancy of this histone variant at the NFATc1 promoter.	Hydrogen	173-176	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	110-116
32108985-0	2020	Hydrogen exerts neuroprotection by activation of the miR-21/PI3K/AKT/GSK-3beta pathway in an in vitro model of traumatic brain injury.	Hydrogen	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	65-68
32108985-2	2020	In this study, we explored neuroprotection of hydrogen-rich medium through activation of the miR-21/PI3K/AKT/GSK-3beta pathway in an in vitro model of traumatic brain injury.	Hydrogen	46-54	AKT serine/threonine kinase 1	Rattus norvegicus	105-108
32108985-12	2020	In conclusion, hydrogen exerted a neuroprotective effect against neuronal apoptosis and impaired nerve regeneration through activation of miR-21/PI3K/AKT/GSK-3beta signalling in this in vitro model of traumatic brain injury.	Hydrogen	15-23	AKT serine/threonine kinase 1	Rattus norvegicus	150-153
32244797-6	2020	The newly formed alphaN helix of hSNF5171-258 interacts with the beta2-alpha1 loop of hSNF5 via hydrogen bonds and it also displays a hydrophobic interaction with BAF155SWIRM.	Hydrogen	96-104	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	33-38
31713923-5	2020	The C terminal tail of CENH3 is confirmed to be responsible for the interaction of CENH3 and histone H4, which indicates that CENH3 maintains deposition in centromeres via interacting with H4 to form stable nucleosomes.	Hydrogen	101-103	centromeric histone H3	Zea mays	23-28
32220144-6	2020	Molecular docking simulation demonstrated that SSYYPFK could bind with the active site S1 of ACE via short hydrogen bonds.	Hydrogen	107-115	angiotensin I converting enzyme	Rattus norvegicus	93-96
31713923-5	2020	The C terminal tail of CENH3 is confirmed to be responsible for the interaction of CENH3 and histone H4, which indicates that CENH3 maintains deposition in centromeres via interacting with H4 to form stable nucleosomes.	Hydrogen	101-103	centromeric histone H3	Zea mays	83-88
31713923-5	2020	The C terminal tail of CENH3 is confirmed to be responsible for the interaction of CENH3 and histone H4, which indicates that CENH3 maintains deposition in centromeres via interacting with H4 to form stable nucleosomes.	Hydrogen	101-103	centromeric histone H3	Zea mays	83-88
31917506-1	2020	An assessment of the C-H activation catalyst [(COD)Ir(IMes)(PPh 3 )]PF 6 in the deuteration of phenyl rings containing different functional directing groups is divulged.	Hydrogen	21-24	caveolin 1	Homo sapiens	60-65
31699563-2	2020	Fluorescence analysis showed that 1-OHNap, 9-OHPhe and 1-OHPyr can form 1:1 complex with CAT, with the binding constant of 6.31 x 103, 1.03 x 104 and 2.96 x 105 L mol-1 at 17  C. Thermodynamic and docking parameters demonstrated that van der Waals" force, hydrogen bonds and hydrophobic interactions dominated the three binding processes.	Hydrogen	256-264	catalase	Homo sapiens	89-92
32135190-6	2020	Analysis by hydrogen/deuterium exchange at peptide resolution showed that the MetF subunit folds to completion in the GroEL/ES nano-cage and binds its cofactor flavin adenine dinucleotide.	Hydrogen	12-20	GroEL	Escherichia coli	118-123
32118414-3	2020	Here we demonstrate enhanced NO3- reduction reaction (NO3-RR) performance on Cu50Ni50 alloy catalysts, including a 0.12 V upshift in the half-wave potential and a 6-fold increase in activity compared to those obtained with pure Cu at 0 V vs reversible hydrogen electrode (RHE).	Hydrogen	252-260	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
31846690-11	2020	K525 has the lowest free binding energy and the strongest hydrogen bonding to human albumin.	Hydrogen	58-66	albumin	Homo sapiens	84-91
32245127-3	2020	It is shown that 7-MG competes with substrate NAD+ and its binding in the PARP-1 active site is mediated by hydrogen bonds and nonpolar interactions with the Gly863, Ala898, Ser904, and Tyr907 residues.	Hydrogen	108-116	poly(ADP-ribose) polymerase 1	Homo sapiens	74-80
32017428-1	2020	The rhodium(III)-catalyzed redox-neutral coupling of alpha-trifluoromethylacrylic acid with bezamides proceeds smoothly accompanied by amide-directed C-H bond cleavage to produce beta-[2-(aminocarbonyl)phenyl]-alpha-trifluoromethylpropanoic acid derivatives.	Hydrogen	150-153	ATPase H+ transporting V0 subunit a2	Homo sapiens	179-186
32073264-3	2020	In the catalytic system, visible light activated benzimidazoline aryloxides (BIH-ArO-), generated in-situ by hydride reduction of the corresponding betaines BI+-ArO-, donate both an electron and a hydrogen atom to the substrates.	Hydrogen	197-205	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	81-84
32073264-3	2020	In the catalytic system, visible light activated benzimidazoline aryloxides (BIH-ArO-), generated in-situ by hydride reduction of the corresponding betaines BI+-ArO-, donate both an electron and a hydrogen atom to the substrates.	Hydrogen	197-205	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	161-164
32091904-2	2020	In this work, this hydrogen abstraction reaction has been investigated at the CCSD(T)/CBS level of theory, suggesting that both pre-barrier complex and saddle point are stabilized in relation to the reactants by 3.31 and 1.35 kcal mol-1, respectively.	Hydrogen	19-27	cystathionine beta-synthase	Homo sapiens	86-89
31953091-3	2020	The structure of tetradeca-thiolated beta-CD was confirmed by FTIR and 1H NMR spectroscopy.	Hydrogen	71-73	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	37-44
32034060-6	2020	The structure reveals an increase in hydrogen bonding between the alpha and beta main chains at the central interface that is introduced by the insertion of four residues in the alpha-chain.	Hydrogen	37-45	complement component 4 binding protein, membrane	Gallus gallus	178-189
32034060-7	2020	The residues in the beta-chain that form hydrogen bonds with the alpha-chain are conserved among all beta alleles.	Hydrogen	41-49	complement component 4 binding protein, membrane	Gallus gallus	65-76
32219100-5	2020	Starting from the docking conformations of FK228 in the binding pockets of HDAC1&6, relatively long MD simulation (500 ns) shown that the hydrophobic interaction and hydrogen bonding of E91 and D92 in the Loop2 of HDAC1 with the Cap had a certain traction effect on FK228, and the sub-pocket formed by Loop1 and Loop2 in HDAC1 could better accommodate the Cap group, which had a positive effect on maintaining the active conformation of FK228.	Hydrogen	166-174	histone deacetylase 1	Homo sapiens	75-82
32178478-8	2020	The molecular docking results showed that the CHEK1 gene can be regulated by microRNAs (miR-195-5p) due to the number of stable hydrogen atoms observed within the distance of 2.0 A and the favorable amino acids (Ala221, Ile353, Ile365, Ile756, Val797, Val70, Val154, Ile159, Val347, Tyr804, Phe811, Tyr815, and Phe156) identified in the binding pocket of the argonaute protein.	Hydrogen	128-136	checkpoint kinase 1	Homo sapiens	46-51
32914119-9	2020	The seven peptides inhibited ACE through hydrogen bonds, electrostatic and hydrophobic interactions; and renin, mainly through hydrogen bonds and hydrophobic interactions.	Hydrogen	41-49	angiotensin I converting enzyme	Homo sapiens	29-32
32914119-9	2020	The seven peptides inhibited ACE through hydrogen bonds, electrostatic and hydrophobic interactions; and renin, mainly through hydrogen bonds and hydrophobic interactions.	Hydrogen	127-135	angiotensin I converting enzyme	Homo sapiens	29-32
32914119-9	2020	The seven peptides inhibited ACE through hydrogen bonds, electrostatic and hydrophobic interactions; and renin, mainly through hydrogen bonds and hydrophobic interactions.	Hydrogen	127-135	renin	Homo sapiens	105-110
32219100-5	2020	Starting from the docking conformations of FK228 in the binding pockets of HDAC1&6, relatively long MD simulation (500 ns) shown that the hydrophobic interaction and hydrogen bonding of E91 and D92 in the Loop2 of HDAC1 with the Cap had a certain traction effect on FK228, and the sub-pocket formed by Loop1 and Loop2 in HDAC1 could better accommodate the Cap group, which had a positive effect on maintaining the active conformation of FK228.	Hydrogen	166-174	histone deacetylase 1	Homo sapiens	75-80
32219100-5	2020	Starting from the docking conformations of FK228 in the binding pockets of HDAC1&6, relatively long MD simulation (500 ns) shown that the hydrophobic interaction and hydrogen bonding of E91 and D92 in the Loop2 of HDAC1 with the Cap had a certain traction effect on FK228, and the sub-pocket formed by Loop1 and Loop2 in HDAC1 could better accommodate the Cap group, which had a positive effect on maintaining the active conformation of FK228.	Hydrogen	166-174	histone deacetylase 1	Homo sapiens	214-219
32220191-11	2020	Compared to the asthma model group, treatment with hydrogen significantly decreased the levels of IL-4 and IL-13 and increased the level of IFN-gamma in BALF ( P<0.05).	Hydrogen	51-59	interleukin 13	Mus musculus	107-112
31629777-0	2020	Molecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ERK-DeltaFosB signaling in the mouse nucleus accumbens.	Hydrogen	10-18	mitogen-activated protein kinase 1	Mus musculus	97-100
32130533-5	2020	Ligand interaction profile of a reference compound revealed a peculiar hydrogen formation of the amino group of 2,4-diaminopyrimidine with active site residue Arg341, possibly forming the bases for its inhibitory prowess against caspase-1.	Hydrogen	71-79	caspase 1	Homo sapiens	229-238
32114886-1	2020	Background hs-cTnT (high-sensitivity cardiac troponin T), but not NT-proBNP (N-terminal pro-B natriuretic peptide), has been shown to predict bleeding in patients with atrial fibrillation.	Hydrogen	11-13	troponin T2, cardiac type	Homo sapiens	14-18
31948726-4	2020	Here, we investigated the conformational changes in beta-arrestin-1 and -2 upon incorporation of phospho-mimetic mutations into the known phosphorylation sites (i.e., S412D for beta-arrestin-1 and S14D, T276D, S14D/T276D, S361D, T383D, and S361D/T383D for beta-arrestin-2) by using hydrogen/deuterium-exchange mass spectrometry (HDX-MS).	Hydrogen	282-290	arrestin beta 1	Homo sapiens	52-74
31948726-4	2020	Here, we investigated the conformational changes in beta-arrestin-1 and -2 upon incorporation of phospho-mimetic mutations into the known phosphorylation sites (i.e., S412D for beta-arrestin-1 and S14D, T276D, S14D/T276D, S361D, T383D, and S361D/T383D for beta-arrestin-2) by using hydrogen/deuterium-exchange mass spectrometry (HDX-MS).	Hydrogen	282-290	arrestin beta 1	Homo sapiens	52-67
31483934-4	2020	Hydrogen sulphide (H2 S) is a gaseous neuromodulator produced in the brain by the enzyme cystathionine beta-synthase (CBS).	Hydrogen	19-21	cystathionine beta synthase	Rattus norvegicus	89-116
31483934-4	2020	Hydrogen sulphide (H2 S) is a gaseous neuromodulator produced in the brain by the enzyme cystathionine beta-synthase (CBS).	Hydrogen	19-21	cystathionine beta synthase	Rattus norvegicus	118-121
31930571-0	2020	Molecular hydrogen regulates PTEN-AKT-mTOR signaling via ROS to alleviate peritoneal dialysis-related peritoneal fibrosis.	Hydrogen	10-18	AKT serine/threonine kinase 1	Homo sapiens	34-37
31930571-0	2020	Molecular hydrogen regulates PTEN-AKT-mTOR signaling via ROS to alleviate peritoneal dialysis-related peritoneal fibrosis.	Hydrogen	10-18	mechanistic target of rapamycin kinase	Homo sapiens	38-42
31930571-8	2020	Furthermore, it has been found that molecular hydrogen alleviate fibrosis by eliminating intracellular ROS and inhibiting the activation of the PTEN/AKT/mTOR pathway.	Hydrogen	46-54	AKT serine/threonine kinase 1	Homo sapiens	149-152
31930571-8	2020	Furthermore, it has been found that molecular hydrogen alleviate fibrosis by eliminating intracellular ROS and inhibiting the activation of the PTEN/AKT/mTOR pathway.	Hydrogen	46-54	mechanistic target of rapamycin kinase	Homo sapiens	153-157
31930571-9	2020	The present data proposes that molecular hydrogen exerts the capacity of anti-peritoneal fibrosis through the ROS/PTEN/AKT/mTOR pathway.	Hydrogen	41-49	AKT serine/threonine kinase 1	Homo sapiens	119-122
31930571-9	2020	The present data proposes that molecular hydrogen exerts the capacity of anti-peritoneal fibrosis through the ROS/PTEN/AKT/mTOR pathway.	Hydrogen	41-49	mechanistic target of rapamycin kinase	Homo sapiens	123-127
32440336-7	2020	The molecular docking studies suggest hydrogen bonding, hydrophobic and pi-pair interactions with the active site of epidermal growth factor receptor, vascular endothelial growth factor receptor 2 and lipoxygenase receptors.	Hydrogen	38-46	epidermal growth factor receptor	Homo sapiens	117-149
29745774-9	2020	2,5-Hexanedione comfortably docked in to the active sites of SOD (-22.857Kcal/mol; KI = 0.9621 microM), GPx (-11.2032Kcal/mol; KI = 0.9813 microM), and CAT (-16.446Kcal/mol; KI = 0.9726 microM) with strong hydrogen bond and hydrophobic interactions.	Hydrogen	206-214	catalase	Rattus norvegicus	152-155
32118214-2	2020	Based on molecular docking analyses with AChE, the meta-hydroxyl group in DC, nonexistent in curcumin, showed the formation of hydrogen bonds with Ser293 and Tyr341 in the binding sites of AChE.	Hydrogen	127-135	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-45
32118214-2	2020	Based on molecular docking analyses with AChE, the meta-hydroxyl group in DC, nonexistent in curcumin, showed the formation of hydrogen bonds with Ser293 and Tyr341 in the binding sites of AChE.	Hydrogen	127-135	acetylcholinesterase (Cartwright blood group)	Homo sapiens	189-193
31904454-2	2020	The results confirmed that the intrinsic fluorescence of HSA was statically quenched by BPQDs mainly through van der Waals interaction and hydrogen bond.	Hydrogen	139-147	albumin	Homo sapiens	57-60
31641820-4	2020	In the initial cytotoxicity screening, N-(3,4,5-trimethoxybenzylidene)-4-(3,4,5-trimethoxybenzyloxy) benzohydrazide, henceforth known as, P5H, was found to be most cytotoxic against human colorectal cancer cell lines (IC50 for HCT-116 = 11.79 muM and HT-29 = 18.52 muM).	Hydrogen	138-141	latexin	Homo sapiens	243-246
31641820-4	2020	In the initial cytotoxicity screening, N-(3,4,5-trimethoxybenzylidene)-4-(3,4,5-trimethoxybenzyloxy) benzohydrazide, henceforth known as, P5H, was found to be most cytotoxic against human colorectal cancer cell lines (IC50 for HCT-116 = 11.79 muM and HT-29 = 18.52 muM).	Hydrogen	138-141	latexin	Homo sapiens	265-268
32220191-11	2020	Compared to the asthma model group, treatment with hydrogen significantly decreased the levels of IL-4 and IL-13 and increased the level of IFN-gamma in BALF ( P<0.05).	Hydrogen	51-59	interferon gamma	Mus musculus	140-149
32175494-11	2020	On the other hand, the hydrogen temperature-programmed reduction measurements indicated improved reducibility of MoO3 in the AgMo/Ti-HMS10 catalyst, which acknowledged the role of Mo6+ in gaining electrons from silver to form positively charged Ag.	Hydrogen	23-31	alkylglycerol monooxygenase	Homo sapiens	125-129
32376537-5	2020	RESULTS: Compared with the PQ-exposed cells, the cells with hydrogen water treatment showed significantly lowered expressions of Col-I, Col-III, and alpha-SMA.	Hydrogen	60-68	actin alpha 1, skeletal muscle	Homo sapiens	149-158
32121212-6	2020	The results of the molecular docking simulation demonstrated that RWDISQPY could bind with the active sites S1 and S2 of ACE via short hydrogen bonds.	Hydrogen	135-143	angiotensin I converting enzyme	Rattus norvegicus	121-124
31951127-4	2020	The key to balancing potency and selectivity while minimizing P-gp mediated efflux was fine-tuning of hydrogen bond acceptor basicity.	Hydrogen	102-110	phosphoglycolate phosphatase	Rattus norvegicus	62-66
31984387-0	2020	Modular synthesis of (C-10 to C-13)-substituted-9,14-diaryl-9,14-dihydrodibenzo[a,c]phenazines via a subsequent Buchwald-Hartwig amination and C-H amination strategy.	Hydrogen	143-146	homeobox C10	Homo sapiens	22-26
31689103-2	2020	Structurally, its ligand binding domain (LBD) harbors the region for the ligand-dependent transcriptional activation function 2 (AF-2), a majorly hydrophobic groove formed by residues from helices H3, H4, and H12, where the H12 position plays a critical role in AF-2 spatial conformation and GR function as a whole.	Hydrogen	201-203	nuclear receptor subfamily 3 group C member 1	Homo sapiens	292-294
31883308-0	2020	Molecular Engineering of Fully-Conjugated sp2 Carbon-Linked Polymers for High-Efficiency Photocatalytic Hydrogen Evolution.	Hydrogen	104-112	Sp2 transcription factor	Homo sapiens	42-45
31922747-2	2020	Hydrogen atom transfer (HAT) by 3O2 and HO2  from arenols (ArOH), aryloxyls (ArO ), their tautomers (ArH), and auxiliary compounds has been investigated by means of CBS-QB3 computations.	Hydrogen	0-8	low density lipoprotein receptor adaptor protein 1	Homo sapiens	101-104
31863837-6	2020	A single binding site of AtGSTF8 towards DEHP was predicted and the binding force was presumed mainly by Van der Waals" force and hydrogen bonding based on static quenching mechanism.	Hydrogen	130-138	glutathione S-transferase phi 8	Arabidopsis thaliana	25-32
32120234-2	2020	The mutant strains 156T-AM and 156T-POL were constructed to have another copy of a gene encoding alpha-amylase or DNA polymerase, respectively, and exhibited growth rates and H2 production rates distinct from those of the parental strain, 156T, in gas fermentation using 100% CO or coal-gasified syngas.	Hydrogen	175-177	alpha-amylase family glycosyl hydrolase	Thermococcus onnurineus NA1	97-110
31985207-3	2020	The structure of per-6-thiolated alpha-CD was approved by FT-IR and 1H NMR spectroscopy.	Hydrogen	68-70	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	33-41
31990180-4	2020	The hydrogen plasma plays an effective role in the transformation of sacrificial sp2-bonded CNWs to sp3-bonded diamond, eventually leading to the template thickening of diamond nanoplatelets in the upper layer.	Hydrogen	4-12	Sp2 transcription factor	Homo sapiens	81-84
31990180-4	2020	The hydrogen plasma plays an effective role in the transformation of sacrificial sp2-bonded CNWs to sp3-bonded diamond, eventually leading to the template thickening of diamond nanoplatelets in the upper layer.	Hydrogen	4-12	Sp3 transcription factor	Homo sapiens	100-103
32015133-7	2020	The crystal structure of the YBX1 CSD-RNA complex reveals that both hydrophobic stacking and hydrogen bonds are critical for m5C binding.	Hydrogen	93-101	Y-box binding protein 1	Homo sapiens	29-33
31887867-7	2020	It has been moreover observed that the release was significantly delayed in CS-Arx-GO-f compared to CS-Arx-f, a fact attributed to the interplay of the ring with the basal and edges of graphene oxide, through pi-pi stacking and additional hydrogen bonding interactions.	Hydrogen	239-247	aristaless related homeobox	Homo sapiens	79-82
31669277-8	2020	Further, the mutations at the hydrophobic amino acids primarily promote the aggregation tendency of SOD1 protein through different destabilizing mechanisms including changes in hydrophobic free energy, loss of electrostatic interactions in the protein"s surface and loss of hydrogen bonds that bridges the protein core and surface.	Hydrogen	274-282	superoxide dismutase 1	Homo sapiens	100-104
31866295-6	2020	A uniform two-fold reduction in 15N/1H NMR signal intensities of Abeta(M1-42) with no observable chemical shift perturbation indicated the formation of a large complex, which was further confirmed by diffusion NMR experiments.	Hydrogen	36-38	amyloid beta precursor protein	Homo sapiens	65-76
32104537-0	2020	Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats.	Hydrogen	0-8	PPARG coactivator 1 alpha	Rattus norvegicus	86-92
32104537-10	2020	These findings suggest that H2 augments cellular antioxidant defense capacity through activation of MAPK signaling pathways, leading to HO-1 expression and subsequent upregulation of PGC-1alpha and SIRT-1 expression.	Hydrogen	28-30	PPARG coactivator 1 alpha	Rattus norvegicus	183-193
32104537-6	2020	Furthermore, H2 inhalation reduced the expression of Bcl-2-associated X protein (BAX) and caspase-3 while promoting the expression of Bcl-2, nuclear factor erythroid-2-related factor 2, and heme oxygenase-1 (HO-1).	Hydrogen	13-15	BCL2, apoptosis regulator	Rattus norvegicus	134-184
32104537-10	2020	These findings suggest that H2 augments cellular antioxidant defense capacity through activation of MAPK signaling pathways, leading to HO-1 expression and subsequent upregulation of PGC-1alpha and SIRT-1 expression.	Hydrogen	28-30	sirtuin 1	Rattus norvegicus	198-204
32048049-0	2020	The hydrogen transfer reaction between the substance of triplet state thioxanthone and alkane with sp3 hybridization hydrogen.	Hydrogen	4-12	Sp3 transcription factor	Homo sapiens	99-102
32104537-15	2020	HO-1 plays an important role in H2-mediated protection through the MAPK/HO-1/PGC-1alpha pathway.	Hydrogen	32-34	PPARG coactivator 1 alpha	Rattus norvegicus	77-87
31951423-8	2020	Hydrophobic interaction and pi-pi stacking, as well as electrostatic attraction, only slightly perturb the microenvironment of the active site of cyt c while hydrogen-bonding interaction is the main driving force for the structural change of the active site.	Hydrogen	158-166	cytochrome c, somatic	Homo sapiens	146-151
31951423-9	2020	Furthermore, long range electrostatic attraction between GO and cyt c may facilitate the short range hydrogen-bonding interaction, which intensifies the hydrogen-bonding-induced structural change.	Hydrogen	101-109	cytochrome c, somatic	Homo sapiens	64-69
31951423-9	2020	Furthermore, long range electrostatic attraction between GO and cyt c may facilitate the short range hydrogen-bonding interaction, which intensifies the hydrogen-bonding-induced structural change.	Hydrogen	153-161	cytochrome c, somatic	Homo sapiens	64-69
31590087-6	2020	The transformation of 2-CDD was accompanied by the resale of Cl ion, and the additional oxygen was proven to be able to consume electrons and hydrogen ions, thus greatly inhibiting the degradation of PCDD in systems.	Hydrogen	142-150	natriuretic peptide A	Homo sapiens	24-27
32048049-0	2020	The hydrogen transfer reaction between the substance of triplet state thioxanthone and alkane with sp3 hybridization hydrogen.	Hydrogen	117-125	Sp3 transcription factor	Homo sapiens	99-102
32048049-3	2020	In our works, two donors with quasi-inert sp3 C-H of skipped diene (3,6-nonadiene) and cyclic acetals (benzodioxole) reacted with type II photoinitiators (triplet state of thioxanthone series, TXs) as acceptors are investigated.	Hydrogen	46-49	Sp3 transcription factor	Homo sapiens	42-45
32029879-6	2020	Treatment of ovalbumin-sensitized and challenged mice with hydrogen reversed the energy metabolic pathway switch, and mitigated airway inflammation.	Hydrogen	59-67	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	13-22
32029879-7	2020	Hydrogen abrogated ovalbumin sensitization and challenge-induced upregulation of glycolytic enzymes and hypoxia-inducible factor-1alpha, and downregulation of mitochondrial respiratory chain complexes and peroxisome proliferator activated receptor-gamma coactivator-1alpha.	Hydrogen	0-8	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	19-28
32029879-8	2020	Hydrogen abrogated ovalbumin sensitization and challenge-induced sirtuins 1, 3, 5 and 6 downregulation.	Hydrogen	0-8	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	19-28
31895552-0	2020	Side Chain Hydrogen-Bonding Interactions within Amyloid-like Fibrils Formed by the Low-Complexity Domain of FUS: Evidence from Solid State Nuclear Magnetic Resonance Spectroscopy.	Hydrogen	11-19	FUS RNA binding protein	Homo sapiens	108-111
31895552-4	2020	Instead, the core-forming segment contains numerous hydroxyl-bearing residues, including 18 serines, six threonines, and eight tyrosines, suggesting that the FUS-LC fibril structure may be stabilized in part by inter-residue hydrogen bonds among side chain hydroxyl groups.	Hydrogen	225-233	FUS RNA binding protein	Homo sapiens	158-161
31895552-7	2020	The data also reveal differences in hydrogen exchange rates with water for different side chain hydroxyl groups, providing information about solvent exposure and penetration of water into the FUS-LC fibril core.	Hydrogen	36-44	FUS RNA binding protein	Homo sapiens	192-195
31017307-10	2020	Lowering endogenous production of H2 S by concomitant silencing of cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) favoured VIC calcification.	Hydrogen	34-36	cystathionine beta-synthase	Homo sapiens	103-130
31879997-3	2020	Here, a new strategy is demonstrated to synthesize active and stable Pt-based electrocatalysts for hydrogen evolution by confining Pt clusters in hollow mesoporous carbon spheres (Pt5 /HMCS).	Hydrogen	99-107	MKKS centrosomal shuttling protein	Homo sapiens	185-189
31806513-2	2020	RCPH-biochar at concentration of 15 g L-1 substantially enhanced hydrogen generation during batch tests, with the highest cumulative hydrogen volume (3990 mL L-1) being 1.7 times that without RCPH-biochar.	Hydrogen	65-73	L1 cell adhesion molecule	Homo sapiens	38-41
31806513-2	2020	RCPH-biochar at concentration of 15 g L-1 substantially enhanced hydrogen generation during batch tests, with the highest cumulative hydrogen volume (3990 mL L-1) being 1.7 times that without RCPH-biochar.	Hydrogen	133-141	L1 cell adhesion molecule	Homo sapiens	158-161
31806513-3	2020	Then, continuous hydrogen production performance demonstrated that RCPH-biochar was capable of retaining biomass in the reactor, at 6 h hydraulic retention time, hydrogen production rate (22.8 mmol H2 L-1 h-1) was tripled compared to the control, meanwhile, glucose and xylose utilization reached to 82.3% and 54.6%, respectively.	Hydrogen	162-170	L1 cell adhesion molecule	Homo sapiens	201-204
31377191-8	2020	In addition, by inspecting the variation in dipole moments of the hydration water molecules around lysozyme, it was suggested that the observed relaxation could be attributed to the orientational relaxation of hydration water molecules participating in the hydrogen-bond network formed around each of the two tryptophan residues.	Hydrogen	257-265	lysozyme	Homo sapiens	99-107
31806513-2	2020	RCPH-biochar at concentration of 15 g L-1 substantially enhanced hydrogen generation during batch tests, with the highest cumulative hydrogen volume (3990 mL L-1) being 1.7 times that without RCPH-biochar.	Hydrogen	133-141	L1 cell adhesion molecule	Homo sapiens	38-41
31017307-13	2020	Valvular calcification in ApoE-/- mice on a high-fat diet was inhibited by H2 S. CONCLUSIONS AND IMPLICATIONS: The endogenous CSE-CBS/H2 S system exerts anti-calcification effects in heart valves providing a novel therapeutic approach to prevent hardening of valves.	Hydrogen	75-77	apolipoprotein E	Mus musculus	26-30
31561157-10	2020	Hydrogen bonding and hydrophobic interactions constituted the primary intermolecular forces between PFCs and the hPXR.	Hydrogen	0-8	nuclear receptor subfamily 1 group I member 2	Homo sapiens	113-117
31812021-6	2020	CAA binds to CAT mainly via van der Waals forces and hydrogen bonds with a stoichiometry of 9.2.	Hydrogen	53-61	catalase	Mus musculus	13-16
31468277-8	2020	Enzyme-linked immunosorbent assay performed on day 7 revealed that hydrogen water reduced the level of the pro-inflammatory cytokine interleukin-6 and increased that of forkhead box P3 transcription factor, suggesting an enhancement of regulatory T cell activity.	Hydrogen	67-75	interleukin 6	Mus musculus	133-146
31908053-7	2020	Molecular docking demonstrated that arctigenin had high affinity for ERbeta mainly through hydrogen bonds as well as hydrophobic effects, and the protective effect of arctigenin on the intestinal barrier function was largely diminished in ERbeta-mutated (ARG346 and/or GLU305) Caco-2 cells.	Hydrogen	91-99	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	69-75
31838617-5	2020	While the applied different concentrations (1%, 10%, 50% and 100%) of hydrogen-rich water (HRW) conducted different affects in alleviating the senescence of cut roses, and 1% HRW displayed the best ornamental quality and the longest vase life by reducing ethylene production, supported by the decrease of 1-aminocyclopropene-1-carboxylate (ACC) accumulation, ACC synthase (ACS) and ACC oxidase (ACO) activities, and Rh-ACS3 and Rh-ACO1 expressions in ethylene biosynthesis.	Hydrogen	70-78	twist family bHLH transcription factor 1	Homo sapiens	419-423
30706763-7	2020	The inhibitor with multihydroxyl side chains shows an obviously large electrostatic interaction as it forms additional hydrogen bonds with AChE.	Hydrogen	119-127	acetylcholinesterase (Cartwright blood group)	Homo sapiens	139-143
32076225-1	2020	At the historic Shelter Island Conference on the Foundations of Quantum Mechanics in 1947, Willis Lamb reported an unexpected feature in the fine structure of atomic hydrogen: a separation of the 2S1/2 and 2P1/2 states1.	Hydrogen	166-174	NADH:ubiquinone oxidoreductase complex assembly factor 3	Homo sapiens	196-211
31823246-10	2020	Molecular modelling of glycopeptide 1 and GpalphaDG1 scFv suggested that their interaction occurs through hydrogen bonds and hydrophobic contacts involving amino acids from scFv (I51, Y33, S229, Y235, and P233) and R8 and alpha-mannose from Glycopeptide 1.	Hydrogen	106-114	immunglobulin heavy chain variable region	Homo sapiens	53-57
31663628-4	2020	The difficulty in proper computational prediction of relative energies, in molecules capable of inter-molecular hydrogen bonding, introduces large errors in the prediction of conformationally averaged NMR properties in methods based on Boltzmann averaging such as DP4 or DP4+.	Hydrogen	112-120	transcription factor Dp family member 3	Homo sapiens	264-267
31663628-4	2020	The difficulty in proper computational prediction of relative energies, in molecules capable of inter-molecular hydrogen bonding, introduces large errors in the prediction of conformationally averaged NMR properties in methods based on Boltzmann averaging such as DP4 or DP4+.	Hydrogen	112-120	transcription factor Dp family member 3	Homo sapiens	271-274
31865778-6	2020	present within to an aromatic nucleus and the structural features such as hydrophobic, ring aromatic and hydrogen bond acceptor/donor are responsible for the enhancement of the BACE1 enzyme inhibitory activity.	Hydrogen	105-113	beta-secretase 1	Homo sapiens	177-182
31760575-11	2020	The sequence-structure-function-virulence link of Dop might have retained in Mtb by reordering hydrophobic and hydrogen bonding patterns in the local structural environment.	Hydrogen	111-119	pup deamidase/depupylase	Mycobacterium tuberculosis H37Rv	50-53
32071922-0	2020	Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB Signaling Pathway.	Hydrogen	0-8	transcription factor EB	Rattus norvegicus	140-144
31756459-9	2020	Finally, the pharmacophore model suggested B aromatic ring, hydrophobic groups at 7-position and hydrogen bond acceptors at 4-position may play a vital role in activation of flavonoids on CYP3A4.	Hydrogen	97-105	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	188-194
32005101-13	2020	For Danish Jersey, wavenumbers that interact with C-H were associated to genes that are involved in fatty acid synthesis, such as AGPAT3, AGPAT6, PPARGC1A, SREBF1, and FADS1.	Hydrogen	50-53	sterol regulatory element binding transcription factor 1	Bos taurus	156-162
32083123-2	2020	The present study aimed to elucidate the mechanism by which hydrogen (H2) affects mitochondrial function in a wild-type (WT) and homozygous nuclear factor erythroid 2-related factor 2 (Nrf2) knockout (KO, Nrf2-/-) murine model of sepsis.	Hydrogen	60-68	nuclear factor, erythroid derived 2, like 2	Mus musculus	140-183
32083123-2	2020	The present study aimed to elucidate the mechanism by which hydrogen (H2) affects mitochondrial function in a wild-type (WT) and homozygous nuclear factor erythroid 2-related factor 2 (Nrf2) knockout (KO, Nrf2-/-) murine model of sepsis.	Hydrogen	60-68	nuclear factor, erythroid derived 2, like 2	Mus musculus	185-189
31991574-8	2020	Four hydrogen bonding interactions were found between HP-beta-CD and -OH groups of the guest in the HP-beta-CD: myricetin complex.	Hydrogen	5-13	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	57-64
31984126-10	2020	This principle of specificity training should be considered when designing future studies to avoid misinterpretation of hs-cTnT elevation.	Hydrogen	120-122	troponin T2, cardiac type	Homo sapiens	123-127
32013233-6	2020	Interestingly, the same residues were found to form strong hydrogen bonds with the ACE inhibitory drug Sampatrilat.	Hydrogen	59-67	angiotensin I converting enzyme	Homo sapiens	83-86
31898897-15	2020	In addition, the barrier heights for the binding of small molecules (H2, OH-, H2O, and CO) to Ir were calculated, and the results indicated that dissociation from Ir is a faster process than the binding of H2O and H2.	Hydrogen	69-71	fibroblast growth factor receptor 1	Homo sapiens	206-216
31979373-2	2020	The generation of hydrogen radical via a homolytic cleavage of the Ar-H bond and the subsequent hydroarylation of phenolates to cyclohexadienes along with cyclization and elimination reactions of cyclohexadienes are critical steps in the base promoted intumescence of phenols.	Hydrogen	18-26	low density lipoprotein receptor adaptor protein 1	Homo sapiens	67-71
31774423-6	2020	The results from 1H-NMR spectroscopy and self-diffusion coefficient measurements by 1H field-gradient NMR indicate a fast proton exchange process between [2-Sema]+ and H2O.	Hydrogen	17-19	semaphorin 3B	Homo sapiens	157-161
31774423-6	2020	The results from 1H-NMR spectroscopy and self-diffusion coefficient measurements by 1H field-gradient NMR indicate a fast proton exchange process between [2-Sema]+ and H2O.	Hydrogen	84-86	semaphorin 3B	Homo sapiens	157-161
31964938-10	2020	The removal of antibiotics from water by PIM-1 is likely to be governed by both surface and pore-filling adsorption and could be facilitated by electrostatic interactions between the aromatic rings and charged functional groups as well as hydrogen bond formation between the adsorbent and adsorbate.	Hydrogen	239-247	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	41-46
31787359-9	2020	The introduction of extra hydrogen bond interaction with mutant Ser797 is efficient method for the design of the fourth-generation EGFR-TKIs.	Hydrogen	26-34	epidermal growth factor receptor	Homo sapiens	131-135
31865709-5	2020	We first validate our method for the prototypical hydrogen exchange reaction and then show how it can capture the effect of vibrational excitation on a symmetric SN2 reaction and radical addition on CO2.	Hydrogen	50-58	solute carrier family 38 member 5	Homo sapiens	162-165
31904962-15	2020	Examination of the beta2 X-ray structure reveals a hydrogen-bonded network leading from the protein surface to Y122.	Hydrogen	51-59	glycoprotein hormone subunit alpha 2	Homo sapiens	19-24
31780304-4	2020	The docking studies showed that the possible hydrogen bond interactions between the carboxyl groups at both ends of the molecule skeleton and several polar residues (such as Ser191, Cys13 and Ser230) in the active site region of CETP could significantly enhance the inhibition activity.	Hydrogen	45-53	cholesteryl ester transfer protein	Homo sapiens	229-233
31904962-18	2020	We propose that the PCET reactions of hydroxamic acids are mediated by a hydrogen-bonded proton wire in the beta2 subunit.	Hydrogen	73-81	glycoprotein hormone subunit alpha 2	Homo sapiens	108-113
31801692-9	2020	Quantum chemical estimates of activation energies of the hydrogen radical abstraction by the reactive compound 1 as well as electron densities of the substrate orbitals led to the conclusion that fatty acid and fatty alcohol oxidations by CYP4B1 are kinetically controlled reactions.	Hydrogen	57-65	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	239-245
31602686-7	2020	Interestingly, the MD analysis of wild complex revealed an interaction between ELA and the Asn532 of H11, which is an essential interaction for the downregulation/degradation of ERalpha, whereas this interaction is not observed in the mutated complex.	Hydrogen	101-104	estrogen receptor 1	Homo sapiens	178-185
31742803-0	2020	Co(III)-Catalyzed C-H Amidation of Dehydroalanine for the Site-Selective Structural Diversification of Thiostrepton.	Hydrogen	18-21	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	3-6
31888991-6	2020	This bimodal RhoA binding of Ect2 is unusual and was confirmed with Forster resonance energy transfer (FRET) and hydrogen-deuterium exchange mass spectrometry (HDX-MS) analyses.	Hydrogen	113-121	ras homolog family member A	Homo sapiens	13-17
32894666-0	2020	Laser Disrupts AKT Hydrogen Network in Cancer.	Hydrogen	19-27	AKT serine/threonine kinase 1	Homo sapiens	15-18
31956784-5	2020	The conserved glutamate and leucine residues (E957 and L959 of JAK1, E930 and L932 of JAK2, and E903 and L905 of JAK3) located in the hinge region stabilized tofacitinib binding through strongly formed hydrogen bonds.	Hydrogen	202-210	Janus kinase 1	Homo sapiens	63-67
31527007-6	2020	From the evolutionary aspect, SiO2/CdO-graphene composite revealed better H2 generation than that of binary photocatalyst (CdO-graphene nanocomposite).	Hydrogen	74-76	cell adhesion associated, oncogene regulated	Homo sapiens	35-38
31527007-7	2020	The results of characterization and photodegradation suggest that SiO2/CdO-graphene material constitutes a new photocatalyst for the degradation of organic contaminants, as well as the development of an efficient hetero-system for hydrogen production.	Hydrogen	231-239	cell adhesion associated, oncogene regulated	Homo sapiens	71-74
30652647-10	2020	Molecular docking studies on EGFR (PDB ID: 1M17) results, the compounds 6d, 6j and 6l showed good dock/PLP scores i.e.-81.28, -73.98 and -75.37 by interacting with Leu-694, Val-702and Gly-772 amino acids via hydrophobic and hydrogen bonds with Asn818 and Met-769.	Hydrogen	224-232	epidermal growth factor receptor	Homo sapiens	29-33
31519408-7	2020	The detector response enhancement factor (DREF) is reported, defined as the peak height of the highest modulated 2D peak divided by the unmodulated 1D peak height (DREF = 2h/1h).	Hydrogen	174-176	zinc finger BED-type containing 1	Homo sapiens	42-46
31519408-7	2020	The detector response enhancement factor (DREF) is reported, defined as the peak height of the highest modulated 2D peak divided by the unmodulated 1D peak height (DREF = 2h/1h).	Hydrogen	174-176	zinc finger BED-type containing 1	Homo sapiens	164-168
31638822-2	2020	The present study investigated the susceptibility of several human basic proline-rich peptides, named P-H, P-D, P-F, P-J, and II-2 as substrates of transglutaminase-2.	Hydrogen	102-105	transglutaminase 2	Homo sapiens	148-166
31676290-4	2020	METHODS: Here, we investigated the structural and allosteric properties of human HSPA1A using hydrogen/deuterium exchange mass spectrometry, surface plasmon resonance and fluorescence polarization-based substrate binding assays.	Hydrogen	94-102	heat shock protein family A (Hsp70) member 1A	Homo sapiens	81-87
31664507-5	2020	Furthermore, the hydrogen bonding between the interfacial oxygen atoms of CeO2 and lysine residues of the cytochrome c in bacteria yields excellent extracellular electron transfer efficiency.	Hydrogen	17-25	cytochrome c, somatic	Homo sapiens	106-118
32072894-8	2020	Interestingly, in addition to some specific structural perturbations mediated by Asp1116 on the dynamics of CBP, our study revealed that the strong hydrogen bond interaction (N-H O) elicited in CBP-Y08197 sequestered Y08197 tightly into the CBP bromodomain active site.	Hydrogen	148-156	CREB binding protein	Homo sapiens	108-111
32072894-8	2020	Interestingly, in addition to some specific structural perturbations mediated by Asp1116 on the dynamics of CBP, our study revealed that the strong hydrogen bond interaction (N-H O) elicited in CBP-Y08197 sequestered Y08197 tightly into the CBP bromodomain active site.	Hydrogen	148-156	CREB binding protein	Homo sapiens	194-197
32072894-8	2020	Interestingly, in addition to some specific structural perturbations mediated by Asp1116 on the dynamics of CBP, our study revealed that the strong hydrogen bond interaction (N-H O) elicited in CBP-Y08197 sequestered Y08197 tightly into the CBP bromodomain active site.	Hydrogen	148-156	CREB binding protein	Homo sapiens	194-197
32894666-4	2020	Paired photons increase photon density and energy at the target, inducing fusion of the AKT hydrogen network in cancer.	Hydrogen	92-100	AKT serine/threonine kinase 1	Homo sapiens	88-91
32894666-5	2020	Thus, targeting the network of the AKT active site by paired photons laser guided electrons catalyzes fusion and dismantles the hydrogen bond network, causing conversion of hydrogen into deuterium or helium.	Hydrogen	128-136	AKT serine/threonine kinase 1	Homo sapiens	35-38
32894666-5	2020	Thus, targeting the network of the AKT active site by paired photons laser guided electrons catalyzes fusion and dismantles the hydrogen bond network, causing conversion of hydrogen into deuterium or helium.	Hydrogen	173-181	AKT serine/threonine kinase 1	Homo sapiens	35-38
32894666-1	2020	The cancer metastatic process is supported by the strong AKT hydrogen bond network.	Hydrogen	61-69	AKT serine/threonine kinase 1	Homo sapiens	57-60
32894666-3	2020	Laser paired photons disrupt the hydrogen network of the AKT active site by laser catalyzed fusion inducing the disappearance of the malignant phenotype.	Hydrogen	33-41	AKT serine/threonine kinase 1	Homo sapiens	57-60
31937177-0	2020	Saturated hydrogen alleviates CCl4-induced acute kidney injury via JAK2/STAT3/p65 signaling.	Hydrogen	10-18	signal transducer and activator of transcription 3	Homo sapiens	72-77
31490743-8	2020	CONCLUSION: Analysis of the complex of 4-aminoantipyrine and Cannabinoid Receptor 1 revealed the pivotal role played by residues Phe 170, Phe 174, Phe 177, Phe 189, Leu 193, Val 196, and Phe 379, besides the conserved hydrogen bond at Ser 383.	Hydrogen	218-226	cannabinoid receptor 1	Homo sapiens	61-83
31702499-0	2020	Effects of hydrogen-rich water on the PI3K/AKT signaling pathway in rats with myocardial ischemia-reperfusion injury.	Hydrogen	11-19	AKT serine/threonine kinase 1	Rattus norvegicus	43-46
31702499-1	2020	AIMS: To confirm the effects of hydrogen-rich water on apoptosis via the PI3K/AKT signaling pathway in rats with myocardial ischemia-reperfusion injury (MIRI).	Hydrogen	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	78-81
31702499-9	2020	RESULT: The PI3K/AKT signaling pathway was significantly activated, while FoxO1, Bim, and Caspase-3 mRNA and protein levels were significantly decreased in the hydrogen-rich water group compared with those in the pre-ischemic and ischemic phase groups.	Hydrogen	160-168	AKT serine/threonine kinase 1	Rattus norvegicus	17-20
31702499-10	2020	PI3K, AKT and p-AKT mRNA and protein expression levels were increased, while the FoxO1, Bim and Caspase-3 expression levels were significantly decreased in the hydrogen-water group compared with those in the control group in the ischemia-reperfusion phase (P&amp;lt;0.05).	Hydrogen	160-168	AKT serine/threonine kinase 1	Rattus norvegicus	6-9
31702499-11	2020	CONCLUSION: Hydrogen-rich water can activate the PI3K/AKT signaling pathway, alleviate ischemia-reperfusion injury in isolated rat hearts, and inhibit cardiomyocyte apoptosis.	Hydrogen	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	54-57
31449814-0	2020	Profiling Insulin Oligomeric States by 1H NMR Spectroscopy for Formulation Development of Ultra-Rapid-Acting Insulin.	Hydrogen	39-41	insulin	Homo sapiens	10-17
31449814-0	2020	Profiling Insulin Oligomeric States by 1H NMR Spectroscopy for Formulation Development of Ultra-Rapid-Acting Insulin.	Hydrogen	39-41	insulin	Homo sapiens	109-116
31290896-3	2020	From the recent mechanistic investigations, we reason that there is a shared initiating mechanism wherein a characteristic SAM methylene radical is proposed to abstract a hydrogen atom from an sp3 carbon or add onto an sp2 carbon center although variations occur thereafter from reaction to reaction, as well as providing a brief insight into some future prospects.	Hydrogen	171-179	Sp3 transcription factor	Homo sapiens	193-196
31809978-6	2020	RESULTS: Our results indicated that in three (H2052, H2452, and MESO-1) among four MM cell lines, ROR1 inhibition had anti-proliferative and apoptotic effects and suppressed the activation of AKT and STAT3.	Hydrogen	53-58	receptor tyrosine kinase like orphan receptor 1	Homo sapiens	98-102
31518222-2	2020	As a kind of endo-beta-dglucuronidase, heparanase is the known only enzyme in mammals which could degrade heparan sulfate(HS) specifically.	Hydrogen	122-124	heparanase	Homo sapiens	39-49
31518222-4	2020	Heparanase takes effect by cleaving thebeta(1,4)-glycosidic between glucosamine residue and glucuronic acid of HS.	Hydrogen	111-113	heparanase	Homo sapiens	0-10
31290896-3	2020	From the recent mechanistic investigations, we reason that there is a shared initiating mechanism wherein a characteristic SAM methylene radical is proposed to abstract a hydrogen atom from an sp3 carbon or add onto an sp2 carbon center although variations occur thereafter from reaction to reaction, as well as providing a brief insight into some future prospects.	Hydrogen	171-179	Sp2 transcription factor	Homo sapiens	219-222
31715212-4	2020	F-N(Me)H-L inhibited ACE activity with an IC50 of 83 nmol/L, V-N(Me)F-R inhibited NEP activity with an IC50 of 1.173 micromol/L and R-N(Me)V-Y inhibited APN activity with an IC50 of 3.94 nmol/L respectively.	Hydrogen	0-8	angiotensin I converting enzyme	Rattus norvegicus	21-24
31783472-4	2020	Moreover, pH can significantly impact the adsorption of both Co(II)/Mn(II) and AOCs due to the competitive adsorption between H(I) and Co(II)/Mn(II) and the electrostatic repulsion between AOCs and zeolites.	Hydrogen	126-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
33204767-8	2020	Results: Stimulation of NR8383 cells with LPS (100 ng/ml) significantly increased the level of TNF-alpha at 1h, 2h and 6h compared to un-stimulated cells.	Hydrogen	108-110	tumor necrosis factor	Rattus norvegicus	95-104
31713416-5	2019	This rate was 2.8 times greater than that obtained using a more conventional MEC with an anion exchange membrane (hydrogen production rate=0.43+-0.1 L-H2/L/d, jmax = 6.5 +-0.3 A/m2) and the same phosphate buffer (pH=7.5+-0.1) for both electrolytes.	Hydrogen	114-122	C-C motif chemokine ligand 28	Homo sapiens	77-80
31769975-9	2019	In the case of CRIP1b, multiple hydrogen bond interactions between Asn437 (CB1R) and Glu77 (CRIP1b) were observed.	Hydrogen	32-40	cannabinoid receptor 1	Homo sapiens	75-79
31794198-0	2019	A Highly Reactive CoIII,IV2(mu-O)2 Diamond Core Complex that Cleaves C-H Bonds.	Hydrogen	69-72	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	18-23
31794215-5	2019	In paramagnetic DRA isomers, electrons are assigned to two, diffuse, triplet-coupled spin-orbitals that localize outside the N-H bonds of a cationic, tetrahedral center or outside bonds on a nearby amide or methyl group.	Hydrogen	125-128	solute carrier family 26 member 3	Homo sapiens	16-19
31591627-2	2019	To address the challenge of reactive rare events, we begin with an ab initio molecular dynamics adaptation of the Caldeira-Leggett system-bath Hamiltonian and apply this approach to the study of the hydrogen transfer rate-determining step in soybean lipoxygenase-1.	Hydrogen	199-207	seed linoleate 13S-lipoxygenase-1	Glycine max	250-264
31529537-5	2019	DFT calculations and MD simulations revealed a very stable hydrogen bond between the 3"-hydroxyl and uracil N1H profoundly restricts flexibility and positioning of each ribityl hydroxyl, potentially impacting their interactions with MR1 and TCR.	Hydrogen	59-67	major histocompatibility complex, class I-related	Homo sapiens	233-236
31842519-7	2019	Molecular docking simulation showed that it could interact with the active ACE site via hydrogen bonds with high binding power.	Hydrogen	88-96	angiotensin I converting enzyme	Rattus norvegicus	75-78
31794201-1	2019	Utilizing the oxygen-bridged 5,5"-oxidiisophthalic acid (H4L) linker, one Co(II)-based 3D porous MOF {[Co5(L)2(OH)2(OH2)2(H2O)4] 2DMF H2O}n (1) with pentanuclear [Co5(mu3-OH)2(mu2-OH2)2]8+ cluster was prepared.	Hydrogen	57-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
31799844-2	2019	L1 displays crystallographic symmetry (orthorhombic, Pccn) higher than its molecular symmetry (point group C1) and also displays supercooling, with a difference in the melting and solidification points of over 100  C. Upon complexation with ZnCl2, L1 engages in both primary cation and secondary anion coordination via hydrogen bonding, and the complex exhibits a room-to-low-temperature single crystal-to-crystal phase transition.	Hydrogen	319-327	L1 cell adhesion molecule	Homo sapiens	0-2
31682447-2	2019	Herein, a hydrogen bond/electrostatic-assisted co-assembly strategy was smartly exploited to uniformly incorporate polymer-coated CD into ordered mesoporous silica framework (CD@MSN).	Hydrogen	10-18	moesin	Homo sapiens	178-181
31643119-3	2019	DFT calculations show that these reactions start with the formation of NacNac-Ga(O)(L) adducts, the oxo ligand of which can easily abstract protons from nearby C-H bonds even for sp 2 -hybridized C. Aliphatic amines do not enter this reaction for kinetic reasons, presumably due to unfavorable steric repulsion.	Hydrogen	160-163	Sp2 transcription factor	Homo sapiens	179-183
31630621-8	2019	DC ACT kidneys showed augmented protein expression of gamma-epithelial sodium channel and NHE3 (sodium-hydrogen antiporter 3).	Hydrogen	103-111	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	90-94
31641439-1	2019	Methanogens are putatively ancestral autotrophs that reduce CO2 with H2 to form biomass using a membrane-bound, proton-motive Fe(Ni)S protein called the energy-converting hydrogenase (Ech).	Hydrogen	69-71	solute carrier family 5 member 5	Homo sapiens	129-133
31641439-2	2019	At the origin of life, geologically sustained H+ gradients across inorganic barriers containing Fe(Ni)S minerals could theoretically have driven CO2 reduction by H2 through vectorial chemistry in a similar way to Ech.	Hydrogen	162-164	solute carrier family 5 member 5	Homo sapiens	99-103
31641439-3	2019	pH modulation of the redox potentials of H2, CO2 and Fe(Ni)S minerals could in principle enable an otherwise endergonic reaction.	Hydrogen	41-43	solute carrier family 5 member 5	Homo sapiens	56-60
31299615-1	2019	Here in we report tris (3-aminopropyl) amine based tripodal receptors L, L1 and L2 which were functionalized with 4-nitrophenyl moieties having thio-urea, amide and sulfonamide as hydrogen bonding moieties respectively, shows a strong selectivity towards cyanide.	Hydrogen	180-188	L1 cell adhesion molecule	Homo sapiens	73-82
31062603-3	2019	The obtained FG-C18 was then characterized on its chemical structure by Fourier transform infrared spectroscopy and 1H-nuclear magnetic resonance.	Hydrogen	116-118	Bardet-Biedl syndrome 9	Homo sapiens	16-19
31563013-6	2019	Docking studies performed on several naphthoquinones highlighted interesting aspects concerning the molecule orientation and hydrogen bonding interactions, which could help to explain the activity of the compounds toward MKK7 and Cdc25B.	Hydrogen	125-133	mitogen-activated protein kinase kinase 7	Homo sapiens	221-225
31938004-7	2019	Hydrogen inhalation resulted in a notable drop in serum insulin-like growth factor 1 (IGF-1) by 48.2 ng/mL at follow-up (95% confidence interval [CI]: from -186.7 to 89.3) (P &lt; 0.05), while IGF-1 levels were elevated by 59.3 ng/mL after placebo intervention (95% CI; from -110.7 to 229.5) (P &lt; 0.05).	Hydrogen	0-8	insulin like growth factor 1	Homo sapiens	56-84
31938004-7	2019	Hydrogen inhalation resulted in a notable drop in serum insulin-like growth factor 1 (IGF-1) by 48.2 ng/mL at follow-up (95% confidence interval [CI]: from -186.7 to 89.3) (P &lt; 0.05), while IGF-1 levels were elevated by 59.3 ng/mL after placebo intervention (95% CI; from -110.7 to 229.5) (P &lt; 0.05).	Hydrogen	0-8	insulin like growth factor 1	Homo sapiens	86-91
31938004-7	2019	Hydrogen inhalation resulted in a notable drop in serum insulin-like growth factor 1 (IGF-1) by 48.2 ng/mL at follow-up (95% confidence interval [CI]: from -186.7 to 89.3) (P &lt; 0.05), while IGF-1 levels were elevated by 59.3 ng/mL after placebo intervention (95% CI; from -110.7 to 229.5) (P &lt; 0.05).	Hydrogen	0-8	insulin like growth factor 1	Homo sapiens	193-198
31710991-5	2019	Based on the predicted activity and XP glide score, three EGFR inhibitors were synthesized and characterized using 1H-NMR, 13C-NMR and MS.	Hydrogen	115-117	epidermal growth factor receptor	Homo sapiens	58-62
31563013-6	2019	Docking studies performed on several naphthoquinones highlighted interesting aspects concerning the molecule orientation and hydrogen bonding interactions, which could help to explain the activity of the compounds toward MKK7 and Cdc25B.	Hydrogen	125-133	cell division cycle 25B	Homo sapiens	230-236
31768722-0	2019	Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.	Hydrogen	10-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	37-41
31535412-16	2019	In addition, H2 inhalation also inhibited BLM-induced epithelial-mesenchymal transitions (EMT) by inhibiting TGF-beta1 to increase the expression level of epithelial cell marker E-cadherin while decrease the expression level of mesenchymal cell marker vimentin in a time-dependent manner.	Hydrogen	13-15	transforming growth factor, beta 1	Rattus norvegicus	109-118
31535412-18	2019	Conclusions H2 inhalation therapy attenuates BLM-induced pulmonary fibrosis by inhibiting TGF-beta1 and relevant oxidative stress and EMT.	Hydrogen	12-14	transforming growth factor, beta 1	Rattus norvegicus	90-99
31628732-5	2019	This recombinant COX-1-10aa-TXAS can effectively pass COX-1-derived intermediate prostaglandin (PG) H2 (PGH2 ) to the active site of TXAS, resulting in an effective chain reaction property to produce the haemostatic prostanoid, TXA2 , rapidly.	Hydrogen	100-102	prostaglandin-endoperoxide synthase 1	Homo sapiens	17-22
31628732-5	2019	This recombinant COX-1-10aa-TXAS can effectively pass COX-1-derived intermediate prostaglandin (PG) H2 (PGH2 ) to the active site of TXAS, resulting in an effective chain reaction property to produce the haemostatic prostanoid, TXA2 , rapidly.	Hydrogen	100-102	thromboxane A synthase 1	Homo sapiens	28-32
31628732-5	2019	This recombinant COX-1-10aa-TXAS can effectively pass COX-1-derived intermediate prostaglandin (PG) H2 (PGH2 ) to the active site of TXAS, resulting in an effective chain reaction property to produce the haemostatic prostanoid, TXA2 , rapidly.	Hydrogen	100-102	prostaglandin-endoperoxide synthase 1	Homo sapiens	54-59
31628732-5	2019	This recombinant COX-1-10aa-TXAS can effectively pass COX-1-derived intermediate prostaglandin (PG) H2 (PGH2 ) to the active site of TXAS, resulting in an effective chain reaction property to produce the haemostatic prostanoid, TXA2 , rapidly.	Hydrogen	100-102	thromboxane A synthase 1	Homo sapiens	133-137
31535412-0	2019	Hydrogen inhalation attenuated bleomycin-induced pulmonary fibrosis by inhibiting TGF-beta1 and relevant oxidative stress and EMT.	Hydrogen	0-8	transforming growth factor, beta 1	Rattus norvegicus	82-91
31535412-4	2019	Our results indicate that, in BLM-induced pulmonary fibrosis, H2 inhalation could attenuate oxidative stress and reversed the formation of pulmonary EMT process by reducing ROS production and inhibiting the expression of TGF-beta1, alpha-SMA and collagen I to improve fibrotic injury and exert anti-fibrogenic effects.	Hydrogen	62-64	transforming growth factor, beta 1	Rattus norvegicus	221-230
31535412-15	2019	However, BLM-induced oxidative stress could be attenuated by H2 inhalation therapy through reducing the contents of ROS, MDA and hydroxyproline, enhancing the activity of glutathione peroxidase and decreasing the expression of TGF-beta1 and TNF-alpha.	Hydrogen	61-63	transforming growth factor, beta 1	Rattus norvegicus	227-236
31535412-15	2019	However, BLM-induced oxidative stress could be attenuated by H2 inhalation therapy through reducing the contents of ROS, MDA and hydroxyproline, enhancing the activity of glutathione peroxidase and decreasing the expression of TGF-beta1 and TNF-alpha.	Hydrogen	61-63	tumor necrosis factor	Rattus norvegicus	241-250
31768722-8	2019	Hydrogen-rich water increased the activation of the Nrf2/ARE signaling pathway, and the levels of mRNA and protein Nrf2, NQO1, HO-1 and SOD-1 were significantly increased (P &lt; 0.05) in the ischemia-reperfusion period compared with the ischemic period.	Hydrogen	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	52-56
31768722-8	2019	Hydrogen-rich water increased the activation of the Nrf2/ARE signaling pathway, and the levels of mRNA and protein Nrf2, NQO1, HO-1 and SOD-1 were significantly increased (P &lt; 0.05) in the ischemia-reperfusion period compared with the ischemic period.	Hydrogen	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	115-119
31768722-8	2019	Hydrogen-rich water increased the activation of the Nrf2/ARE signaling pathway, and the levels of mRNA and protein Nrf2, NQO1, HO-1 and SOD-1 were significantly increased (P &lt; 0.05) in the ischemia-reperfusion period compared with the ischemic period.	Hydrogen	0-8	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	121-125
31768722-8	2019	Hydrogen-rich water increased the activation of the Nrf2/ARE signaling pathway, and the levels of mRNA and protein Nrf2, NQO1, HO-1 and SOD-1 were significantly increased (P &lt; 0.05) in the ischemia-reperfusion period compared with the ischemic period.	Hydrogen	0-8	superoxide dismutase 1	Rattus norvegicus	136-141
31768722-10	2019	Compared with the ischemic period, the ischemia-reperfusion phase showed significantly increased SOD activity and significantly decreased MDA content in the hydrogen-rich water group, while SOD activity was significantly decreased, and MDA content was significantly increased in the control group (P &lt; 0.05).	Hydrogen	157-165	superoxide dismutase 1	Rattus norvegicus	97-100
31768722-1	2019	The effects of hydrogen-rich water on oxidative stress via the Nrf2/ARE signaling pathway were studied in rats with myocardial ischemia-reperfusion injury (MIRI).	Hydrogen	15-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
31768722-11	2019	Hydrogen-rich water can activate the Nrf2/ARE signaling pathway, alleviate ischemia-reperfusion injury in isolated rat hearts and reduce the oxidative stress level of myocardial tissue.	Hydrogen	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	37-41
31583572-9	2019	Molecular docking studies showed that amygdalin interacts with the active site amino acids of Bcl-2 and HER2 through hydrogen bonding and some hydrophobic interactions.	Hydrogen	117-125	BCL2 apoptosis regulator	Homo sapiens	94-99
30734613-5	2019	Molecular docking modes showed that 5c could reasonably bind to the active site of Bcl-2 protein through strong intermolecular hydrogen bonds and significant hydrophobic effect.	Hydrogen	127-135	BCL2 apoptosis regulator	Homo sapiens	83-88
31246713-6	2019	Specifically, IL-1beta significantly increased from pre- to 5 min after both trials (23%, p&lt;0.05), IL-6 increased 1h following both trials (39%, p&lt;0.05), IL-10 was elevated 5 min after running (20%, p&lt;0.05) and 1h after both running and cycling (41% and 64%, respectively, p&lt;0.05), and TNF-alpha increased 5 min after running (10%, p&lt;0.05).	Hydrogen	117-119	interleukin 6	Homo sapiens	102-106
31328371-2	2019	In this work, an absorption and luminescence study showed that HXR and human serum albumin (HSA) formed a new complex through hydrogen bonds and van der Waals forces at ground state.	Hydrogen	126-134	albumin	Homo sapiens	77-90
31583572-9	2019	Molecular docking studies showed that amygdalin interacts with the active site amino acids of Bcl-2 and HER2 through hydrogen bonding and some hydrophobic interactions.	Hydrogen	117-125	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-108
31493543-7	2019	The pharmacophore model indicated the aromatic ring B, hydrophobic groups and hydrogen bond acceptors may play critical role in the potency of flavonoids inhibition on BCRP.	Hydrogen	78-86	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	168-172
31614165-4	2019	Molecular docking experiments confirmed that the higher inhibitory potency of TTP and gAgAP might be attributed to the formation of several critical hydrogen bonds with the active site residues in ACE.	Hydrogen	149-157	angiotensin I converting enzyme	Rattus norvegicus	197-200
31857841-6	2019	We screened a 3D-enriched fragment library against BRD4(D1) via 1H CPMG NMR with a protein-observed 19F NMR secondary assay.	Hydrogen	64-71	bromodomain containing 4	Homo sapiens	51-55
31849603-5	2019	Restoration of HDAC1 and HDAC2 activities (as evident from the increased acetylation of histones H3 and H4) using simvastatin significantly improves the cognitive deficit and social interaction behavior in AS mice.	Hydrogen	104-106	histone deacetylase 2	Mus musculus	25-30
31766716-2	2019	Spectroscopic constants for two low-lying states that result from internal rotation of the CH4 subunit were detected for each of the two isotopic varieties H4C   35ClF and H4C   37ClF and were analysed to show that ClF lies on the symmetry axis with Cl located closer than F to the C atom, at the distance r0(C   Cl)   3.28 A and with an intermolecular stretching force constant ksigma   4 N m-1.	Hydrogen	156-159	CLQTL1	Homo sapiens	164-167
31566950-7	2019	The present study illustrated that the proposed ligand has considerable hydrophobic interactions and hydrogen bonding with monomeric Abeta in the presence of zinc metal ion.	Hydrogen	101-109	amyloid beta precursor protein	Homo sapiens	133-138
31758024-7	2019	Besides, pharmacophore and flexible docking showed that the pi interaction and hydrogen bond were the key interactions in ACE-EWL complex.	Hydrogen	79-87	angiotensin I converting enzyme	Homo sapiens	122-125
31689487-9	2019	Hydrogen promoted autophagy related protein expression, inhibited the inflammasome NLRP3 pathway activation, and relieved the hyperpathia induced by neuropathic pain.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	83-88
31689487-10	2019	Hydrogen treatment could alleviate hyperpathia by autophagy-mediated NLRP3 inactivation.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	69-74
31647679-0	2019	Non-Adiabatic Ultracold Quantum Reactive Scattering of Hydrogen with Vibrationally Excited HD(v=5-9).	Hydrogen	55-63	CD101 molecule	Homo sapiens	94-99
31661243-8	2019	Furthermore, the results obtained after molecular docking indicated that CA is interacting with insulin via hydrogen bonds.	Hydrogen	108-116	insulin	Homo sapiens	96-103
31622088-2	2019	In addition to C-H bonds with varied electronic properties, the Co(II)-based metalloradical system features chemoselective amination of allylic C-H bonds and is compatible with heteroaryl groups, producing functionalized 5-membered chiral cyclic sulfonamides in high yields with high enantioselectivities.	Hydrogen	15-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
31664822-6	2019	ACP-ISD11 forms a cooperative unit stabilized by several ionic interactions, hydrogen bonds, and apolar interactions.	Hydrogen	77-85	LYR motif containing 4	Homo sapiens	4-9
31803713-3	2019	Furthermore, (S p-D )-GP5 and (R p-D )-GP5 can not racemize according to dynamic 1H NMR and CD spectra.	Hydrogen	81-83	glycoprotein V platelet	Homo sapiens	22-25
31803713-3	2019	Furthermore, (S p-D )-GP5 and (R p-D )-GP5 can not racemize according to dynamic 1H NMR and CD spectra.	Hydrogen	81-83	glycoprotein V platelet	Homo sapiens	39-42
31819365-11	2019	Further molecular modeling analysis indicated that luteolin interacted with STAT3 primarily through hydrogen bond interaction.	Hydrogen	100-108	signal transducer and activator of transcription 3	Mus musculus	76-81
31724756-7	2019	Treatment with Hcy dampens the expression of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) then cuts down H2 S production in cultured HUVECs, however, E2beta reverses this process.	Hydrogen	130-132	cystathionine beta-synthase	Homo sapiens	45-72
31622088-3	2019	The unique profile of reactivity and selectivity of the Co(II)-catalyzed C-H amination is attributed to its underlying stepwise radical mechanism, which is supported by several lines of experimental evidence.	Hydrogen	73-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
31726777-4	2019	Herein, we have used hydrogen/deuterium exchange monitored by mass spectrometry (HDXMS) to investigate the structural dynamics of NQO1 in three ligation states: without ligands (NQO1apo), with FAD (NQO1holo) and with FAD and the inhibitor dicoumarol (NQO1dic).	Hydrogen	21-29	NAD(P)H quinone dehydrogenase 1	Homo sapiens	130-134
31633931-9	2019	Molecular dynamics simulations of both S39E and phosphorylated S39 HDAC8 demonstrate that the perturbation of the L1 loop likely occurs because of the lost hydrogen bond between D29 and S39.	Hydrogen	156-164	elaC ribonuclease Z 1	Homo sapiens	178-181
31703296-6	2019	Our computational structure-based drug design analysis and molecular docking simulation revealed important interactions between carotenoids and Abeta via hydrogen bonding and van der Waals interactions, and shows that carotenoids are powerful anti-amyloidogenic molecules with a potential role in preventing AD, especially since most of them can cross the blood-brain barrier and are considered nutraceutical compounds.	Hydrogen	154-162	amyloid beta precursor protein	Homo sapiens	144-149
31603693-10	2019	Incorporation of a well-positioned base to accept and donate back a hydrogen bond upshifts the Tyr  potential into a range where it can effectively oxidize Cc.	Hydrogen	68-76	cytochrome c, somatic	Homo sapiens	156-158
31703463-6	2019	These results supported successful surface modification and indicated that the surface-tailored CNF/NS nanohybrid possesses excellent adhesion with SPI matrix through covalent and hydrogen-bonding interactions.	Hydrogen	180-188	chromogranin A	Homo sapiens	148-151
31654211-8	2019	The hydrogen-bond interactions, hydrophobic contacts, and pi-pi stacking interactions of BTT with flap residues (Val67-Asp77) of BACE1 confine the movement of the flap and help to achieve closed (non-active) conformation.	Hydrogen	4-12	beta-secretase 1	Homo sapiens	129-134
31807030-6	2019	Pharmacophore study showed that ChalcEA shares similar features with the known hERalpha antagonist, 4-hydroxytamoxifen (4-OHT), which has hydrogen bond donor (HBD), hydrogen bond acceptor (HBA), ring aromaticity (RA), and hydrophobicity (Hy) features.	Hydrogen	138-146	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	79-87
31608342-7	2019	Furthermore, due to the specificity of the MEK5/ERK5 protein structure, the binding sites and binding patterns of BCA and MEK5 were analyzed using molecular docking correlation techniques, which showed that there are stable hydrogen bonds between BCA and the PB1 domain of MEK5 as well as its kinase domain.	Hydrogen	224-232	mitogen-activated protein kinase kinase 5	Homo sapiens	43-47
31563696-13	2019	Appreciable binding interactions were observed for compound 7c containing COX-2 pharmacophore (SO2NH2), with binding energy -10.6652 Kcal/mol, forming two hydrogen bonding interactions with His90 and Tyr355 amino acids.	Hydrogen	155-163	cytochrome c oxidase subunit 2	Saccharomyces cerevisiae S288C	74-79
31753071-5	2019	In our simulation, both CoI and CoII-H feature a strong interaction with the surrounding solvent via hydrogen bonding, which is expected to foster the following catalytic step.	Hydrogen	101-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
31561314-9	2019	The interaction of TCS with RIP1 and ASK1 were mostly hydrophobic; however, hydrogen bond type interaction was found in TCS/Bcl2 complex.	Hydrogen	76-84	BCL2 apoptosis regulator	Homo sapiens	124-128
31491697-10	2019	In addition, OH-PCBs could form hydrogen bonds with amino acids Glu316 and Arg247 while PCBs and PCB sulfates could not, which might be the main factor impacting the binding affinity and agonistic activity.	Hydrogen	32-40	pyruvate carboxylase	Homo sapiens	16-19
31445206-9	2019	NMR studies revealed that there are two exchangeable hydrogens, one of which is on the alpha-carbon, justifying the carbon-centred edaravone radical produced from MPO.	Hydrogen	53-62	myeloperoxidase	Homo sapiens	163-166
31737059-11	2019	In contrast, knockdown of RFX1 in CD14+ monocytes reduced the recruitments of HDAC1 and SUV39H1 in the MCP1 promoter region, thereby facilitating H3 and H4 acetylation and H3K9 tri-methylation in this region.	Hydrogen	153-155	regulatory factor X1	Homo sapiens	26-30
31608342-7	2019	Furthermore, due to the specificity of the MEK5/ERK5 protein structure, the binding sites and binding patterns of BCA and MEK5 were analyzed using molecular docking correlation techniques, which showed that there are stable hydrogen bonds between BCA and the PB1 domain of MEK5 as well as its kinase domain.	Hydrogen	224-232	mitogen-activated protein kinase kinase 5	Homo sapiens	122-126
31608342-7	2019	Furthermore, due to the specificity of the MEK5/ERK5 protein structure, the binding sites and binding patterns of BCA and MEK5 were analyzed using molecular docking correlation techniques, which showed that there are stable hydrogen bonds between BCA and the PB1 domain of MEK5 as well as its kinase domain.	Hydrogen	224-232	mitogen-activated protein kinase kinase 5	Homo sapiens	122-126
30486721-13	2019	In silico docking showed that hydrogen bonds and hydrophobic interactions contributed to the inhibition of Schisandrin B on CES1, Anwuligan on CES2, and Schisandrin B on CES2.	Hydrogen	30-38	carboxylesterase 2	Homo sapiens	143-147
31491736-6	2019	According to theoretical analysis, hydrogen bonding, van der Waals, and hydrophobic forces are the main binding interactions for each V(V) complex and AChE.	Hydrogen	35-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	151-155
31462456-7	2019	Meanwhile, a molecular docking study indicated that ISL could stably form aromatic interactions and hydrogen bonds within the kinase domain of FLT3.	Hydrogen	100-108	fms related receptor tyrosine kinase 3	Homo sapiens	143-147
30486721-13	2019	In silico docking showed that hydrogen bonds and hydrophobic interactions contributed to the inhibition of Schisandrin B on CES1, Anwuligan on CES2, and Schisandrin B on CES2.	Hydrogen	30-38	carboxylesterase 2	Homo sapiens	170-174
31655060-3	2019	Despite a wide distribution of the receptor mutation sites, different THRbeta mutants induce allosteric conformational modulation on the same His435 residue, which disrupts a critical hydrogen bond required for the binding of thyroid hormones.	Hydrogen	184-192	thyroid hormone receptor beta	Homo sapiens	70-77
31468690-4	2019	CTH promotes NF-kappaB nuclear translocation through H2 S-mediated sulfhydration on cysteine-38 of the NF-kappaB p65 subunit, resulting in increased IL-1beta expression and H2 S-induced cell invasion.	Hydrogen	53-55	nuclear factor kappa B subunit 1	Homo sapiens	13-22
31741543-2	2019	Herein, an indium(III)-catalyzed one-pot domino reaction for the synthesis of highly functionalized 4H-Pys, and a model of 1,4-DHP is reported.	Hydrogen	100-102	dihydropyrimidinase	Homo sapiens	127-130
31518499-8	2019	Double-mutant cycle analyses revealed that C(10) substitution generally strengthens the newly established second cation-pi interaction, while it weakens the hydrogen bond typically seen to LeuE in the complementary subunit.	Hydrogen	157-165	homeobox C10	Homo sapiens	43-48
31565919-2	2019	In this study, the distinct adsorption behaviors of heavy metals (Pb(II) and Cu(II)) on different phases of MoS2 (metallic phase (1T) and semiconducting phase (2H)) were theoretically and experimentally investigated.	Hydrogen	160-162	submaxillary gland androgen regulated protein 3B	Homo sapiens	66-83
31560017-1	2019	Self-assembly reactions of CoII ions in the presence of the 2,2-bipyrimidine (bpym) ligand produced both a dinuclear and an octanuclear cation with the nuclearity being governed by hydrogen-bonding versus anion-pi interactions between the anions and the ligands.	Hydrogen	181-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-31
31656914-5	2019	The fluorescence spectroscopy and molecular computation results show that the mixture of caffeine and SOD can result in the formation of a 1:1 complex through hydrogen bond and van der Waals forces spontaneously.	Hydrogen	159-167	superoxide dismutase 1	Homo sapiens	102-105
31468690-4	2019	CTH promotes NF-kappaB nuclear translocation through H2 S-mediated sulfhydration on cysteine-38 of the NF-kappaB p65 subunit, resulting in increased IL-1beta expression and H2 S-induced cell invasion.	Hydrogen	53-55	nuclear factor kappa B subunit 1	Homo sapiens	103-112
31468690-4	2019	CTH promotes NF-kappaB nuclear translocation through H2 S-mediated sulfhydration on cysteine-38 of the NF-kappaB p65 subunit, resulting in increased IL-1beta expression and H2 S-induced cell invasion.	Hydrogen	53-55	interleukin 1 beta	Homo sapiens	149-157
31468690-6	2019	Together, our findings provide evidence that CTH generated H2 S promotes prostate cancer progression and metastasis through IL-1beta/NF-kappaB signaling pathways.	Hydrogen	59-61	interleukin 1 beta	Homo sapiens	124-132
31468690-6	2019	Together, our findings provide evidence that CTH generated H2 S promotes prostate cancer progression and metastasis through IL-1beta/NF-kappaB signaling pathways.	Hydrogen	59-61	nuclear factor kappa B subunit 1	Homo sapiens	133-142
31302375-0	2019	Binding of quinazolinones to c-KIT G-quadruplex; an interplay between hydrogen bonding and pi-pi stacking.	Hydrogen	70-78	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	29-34
31028611-0	2019	NMR assignment of free 1H, 15N and 13C-Grb2-SH2 domain.	Hydrogen	23-25	growth factor receptor bound protein 2	Homo sapiens	39-43
31388821-4	2019	Here, we report the nearly complete 1H, 13C, and 15N backbone and side chain resonance assignments of TGIF1 C-terminal domain (residues 256-375), laying a foundation for further research on the structure-function relationship of TGIF1.	Hydrogen	36-38	TGFB induced factor homeobox 1	Homo sapiens	102-107
31319298-7	2019	The docking analysis suggested that there are interactions between cadinanes from H. inuloides and MDR1, MRP1, and BCRP proteins mainly through pi-pi interactions and hydrogen bonds.	Hydrogen	167-175	ATP binding cassette subfamily B member 1	Homo sapiens	99-103
31319298-7	2019	The docking analysis suggested that there are interactions between cadinanes from H. inuloides and MDR1, MRP1, and BCRP proteins mainly through pi-pi interactions and hydrogen bonds.	Hydrogen	167-175	ATP binding cassette subfamily B member 1	Homo sapiens	105-109
31319298-7	2019	The docking analysis suggested that there are interactions between cadinanes from H. inuloides and MDR1, MRP1, and BCRP proteins mainly through pi-pi interactions and hydrogen bonds.	Hydrogen	167-175	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	115-119
31310953-3	2019	The structures of synthesized thermosensitive beta-CD PPZ and Ad-RGD were confirmed by 1H NMR and FT-IR.	Hydrogen	87-89	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	46-53
31146155-9	2019	The LC-PCB sulfates formed hydrogen bond interaction with arginine 228 residue of TRalpha by their sulfate groups, which might facilitate the TR binding and agonistic activity.	Hydrogen	27-35	pyruvate carboxylase	Homo sapiens	7-10
31581577-11	2019	Among the three hits, ZINC32124535 was identified as the best potential hit based on the hydrogen bond interaction percentage with Asp residue [5HT2A (Asp 155:60%); 5HT2B (Asp155: No interaction); 5HT2C (Asp 134:86%)].	Hydrogen	89-97	5-hydroxytryptamine receptor 2A	Homo sapiens	144-149
31295412-3	2019	Here, we investigated the effect of H2 on free-radical-induced cytotoxicity using tert-butyl hydroperoxide in a human acute monocytic leukemia cell line, THP-1.	Hydrogen	36-38	GLI family zinc finger 2	Homo sapiens	154-159
31478604-2	2019	Treatment of fac-[Ir(aet)3 ] with aqueous HBF4 under aerobic conditions gave dinuclear [Ir2 (aet)4 (cysta)]2+ ([1]2+ ; cysta=cystamine) with a single S-S disulfide bond, while dimeric [Ir2 (aet)3 (Haet)3 ](BF4 )3 ([2](BF4 )3 ) with a triple S-H   S hydrogen bond was formed by similar treatment under anaerobic conditions.	Hydrogen	249-257	FA complementation group C	Homo sapiens	13-16
30660761-0	2019	Insulin resistance and NAFLD: Relationship with intrahepatic iron and serum TNF-alpha using 1H MR spectroscopy and MRI.	Hydrogen	92-94	insulin	Homo sapiens	0-7
30660761-0	2019	Insulin resistance and NAFLD: Relationship with intrahepatic iron and serum TNF-alpha using 1H MR spectroscopy and MRI.	Hydrogen	92-94	tumor necrosis factor	Homo sapiens	76-85
31254919-8	2019	The supramolecular interaction between compound 10b and human serum albumin (HSA) was a static quenching, and the binding process was spontaneous, where hydrogen bonds and van der Waals force played vital roles in the supramolecular transportation of the active compound 10b by HSA.	Hydrogen	153-161	albumin	Homo sapiens	62-75
31362025-2	2019	To get a generalized picture of hydrogen bond network of water surrounding human serum albumin (HSA), near-infrared (NIR) spectroscopy was adopted to explore the hydration induced structural changes of water with HSA concentration from 0.015 to 0.746 mmol/L.	Hydrogen	32-40	albumin	Homo sapiens	81-94
31125141-4	2019	Through molecular docking, it was found that the AKB-9778 was docked well in the binding pocket of VE-PTP by the interactions of hydrogen bond and Van der Waals.	Hydrogen	129-137	protein tyrosine phosphatase receptor type B	Homo sapiens	99-105
31207545-7	2019	We found that Mag H2, notwithstanding its enhanced hydrophobicity, has a pore formation mechanism compatible with the toroidal pore model similar to that of wt Mag 2.	Hydrogen	18-20	reticulophagy regulator family member 2	Homo sapiens	160-165
31340188-7	2019	Epo association rate, kon, was estimated to be 0.00610 pM-1h-1, and the dissociation rate koff was 0.112 h-1.	Hydrogen	58-60	erythropoietin	Homo sapiens	0-3
31382032-4	2019	Characterization studies using DSC, 1H NMR, XRPD and molecular simulation demonstrated that the NLG919/HP-beta-CD loading mechanism involved an increasing pH-dependent binding affinity.	Hydrogen	36-38	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	106-113
31391291-8	2019	Structural analyses reveal how distinct steroid drugs bind to GR with different affinities by unique hydrogen bonds and hydrophobic interactions.	Hydrogen	101-109	nuclear receptor subfamily 3 group C member 1	Homo sapiens	62-64
31645723-2	2019	Cleavage of an sp3 C-H bond via hydrogen atom transfer (HAT) is particularly useful, given the large number of available HAT acceptors and the diversity of reaction pathways available to the resulting radical intermediate6-17.	Hydrogen	32-40	Sp3 transcription factor	Homo sapiens	15-18
31301288-7	2019	Thermodynamic and molecular docking investigations suggested that catalase has one binding site for SNY, and hydrogen binding plays a main role in the binding reaction of catalase -SNY complex.	Hydrogen	109-117	catalase	Homo sapiens	66-74
31391251-6	2019	We found that the molecular switch involves a hydrogen bond interaction between Tyr-73 of mCD1d and the amide group oxygen of alphaGSAs.	Hydrogen	46-54	CD1d1 antigen	Mus musculus	90-95
31301288-7	2019	Thermodynamic and molecular docking investigations suggested that catalase has one binding site for SNY, and hydrogen binding plays a main role in the binding reaction of catalase -SNY complex.	Hydrogen	109-117	catalase	Homo sapiens	171-179
31309671-2	2019	Our experiments and density functional theory (DFT) calculations show the 3D p-FGDY/CC network is highly active and it is a high potential metal-free catalyst for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER), as well as overall water splitting (OWS) under both acidic and alkaline conditions.	Hydrogen	167-175	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	79-83
31768122-5	2019	Occurrence of salinity induction in expression of SlSOS2 and P5CS, encoding a sodium/hydrogen antiporter and an enzyme for proline biosynthesis, is limited specifically to the morning, whereas that of SlDREB2, which encodes a transcription factor involved in tomato responses to several abiotic stresses such as salinity and drought, is restricted specifically to the evening.	Hydrogen	85-93	delta-1-pyrroline-5-carboxylate synthase	Solanum lycopersicum	61-65
31768122-5	2019	Occurrence of salinity induction in expression of SlSOS2 and P5CS, encoding a sodium/hydrogen antiporter and an enzyme for proline biosynthesis, is limited specifically to the morning, whereas that of SlDREB2, which encodes a transcription factor involved in tomato responses to several abiotic stresses such as salinity and drought, is restricted specifically to the evening.	Hydrogen	85-93	calcineurin B-like interacting protein kinase	Solanum lycopersicum	50-56
31608287-11	2019	The resulting 2H solid-state NMR spectra show an increase in order for p24 and DQ alpha-1 which both carry the SM recognition motif.	Hydrogen	14-16	transmembrane p24 trafficking protein 2	Homo sapiens	71-74
31271801-8	2019	Docking simulations showed binding affinities of compounds 1 to 5 for hMAO-B were higher than those for hMAO-A or AChE and suggested these five chalcones form hydrogen bonds with MAO-B at Cys172 but that they do not form hydrogen bonds with hMAO-A or AChE.	Hydrogen	159-167	acetylcholinesterase (Cartwright blood group)	Homo sapiens	114-118
31228217-3	2019	Here, we create these microstructures via the pyrolysis of a microporous polymer (PIM-1) under low concentrations of hydrogen gas.	Hydrogen	117-125	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	82-87
31228217-5	2019	The H2 assisted CMS dense membranes show a dramatic increase in p-xylene ideal permeability ( 15 times), with little loss in p-xylene/o-xylene selectivity (18.8 vs. 25.0) when compared to PIM-1 membranes pyrolyzed under a pure argon atmosphere.	Hydrogen	4-6	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	188-193
31125827-2	2019	EXPERIMENTS: BU-PPG and A-MA were successfully developed and exhibited specific recognition and high affinity, which enabled reversible complementary adenine-uracil (A-U) hydrogen bonding-induced formation of spherical micelles in aqueous solution.	Hydrogen	171-179	serglycin	Homo sapiens	16-19
31536605-9	2019	Additionally, the interaction between EGFR and ATP was favored by DeltaELREA EGFR over wild-type EGFR, as reflected by the number of hydrogen bonds formed and the free energy of binding.	Hydrogen	133-141	epidermal growth factor receptor	Homo sapiens	38-42
31536605-9	2019	Additionally, the interaction between EGFR and ATP was favored by DeltaELREA EGFR over wild-type EGFR, as reflected by the number of hydrogen bonds formed and the free energy of binding.	Hydrogen	133-141	epidermal growth factor receptor	Homo sapiens	77-81
31536605-9	2019	Additionally, the interaction between EGFR and ATP was favored by DeltaELREA EGFR over wild-type EGFR, as reflected by the number of hydrogen bonds formed and the free energy of binding.	Hydrogen	133-141	epidermal growth factor receptor	Homo sapiens	77-81
31176051-6	2019	As expected, the hydrogen bond-assisted 2D/2D Z-scheme SnNb2O6/Bi2WO6 system results in an outstanding improvement of the norfloxacin (NOR) photodegradation efficiency, and the degradation rate constant (4.06 x 10-2 min-1) is 9 and 2 times higher than those of SnNb2O6 (4.33 x 10-3 min-1), and Bi2WO6 (1.70 x 10-2 min-1), respectively.	Hydrogen	17-25	CD59 molecule (CD59 blood group)	Homo sapiens	216-221
31176051-6	2019	As expected, the hydrogen bond-assisted 2D/2D Z-scheme SnNb2O6/Bi2WO6 system results in an outstanding improvement of the norfloxacin (NOR) photodegradation efficiency, and the degradation rate constant (4.06 x 10-2 min-1) is 9 and 2 times higher than those of SnNb2O6 (4.33 x 10-3 min-1), and Bi2WO6 (1.70 x 10-2 min-1), respectively.	Hydrogen	17-25	CD59 molecule (CD59 blood group)	Homo sapiens	282-287
31176051-6	2019	As expected, the hydrogen bond-assisted 2D/2D Z-scheme SnNb2O6/Bi2WO6 system results in an outstanding improvement of the norfloxacin (NOR) photodegradation efficiency, and the degradation rate constant (4.06 x 10-2 min-1) is 9 and 2 times higher than those of SnNb2O6 (4.33 x 10-3 min-1), and Bi2WO6 (1.70 x 10-2 min-1), respectively.	Hydrogen	17-25	CD59 molecule (CD59 blood group)	Homo sapiens	282-287
31356907-11	2019	SIGNIFICANCE: These results suggest that H2 has antithrombotic effects, which may be due to its antioxidant property and subsequent inhibition of platelet activation via NO/cGMP/PKG/ERK pathway.	Hydrogen	41-43	Eph receptor B1	Rattus norvegicus	182-185
31506468-6	2019	The formation of stable hydrogen bond interactions with the residues Phe202 and Lys220 of GRK2 seems to be important for selective inhibition of GRK2.	Hydrogen	24-32	G protein-coupled receptor kinase 2	Homo sapiens	90-94
31506468-6	2019	The formation of stable hydrogen bond interactions with the residues Phe202 and Lys220 of GRK2 seems to be important for selective inhibition of GRK2.	Hydrogen	24-32	G protein-coupled receptor kinase 2	Homo sapiens	145-149
31483550-6	2019	Moreover, H2 S decreased the levels of oxidative stress, the expression of pro-inflammatory factors including tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1) and interleukin 6 (IL-6), and the apoptosis of hepatocytes.	Hydrogen	10-12	tumor necrosis factor	Rattus norvegicus	110-137
31709059-0	2019	Diversifying molecular and topological space via a supramolecular solid-state synthesis: a purely organic mok net sustained by hydrogen bonds.	Hydrogen	127-135	MOK protein kinase	Homo sapiens	106-109
31709059-1	2019	A three-dimensional hydrogen-bonded network based on a rare mok topology has been constructed using an organic molecule synthesized in the solid state.	Hydrogen	20-28	MOK protein kinase	Homo sapiens	60-63
31709059-6	2019	The cyclo-butane adopts different conformations to provide combinations of hydrogen-bond donor and acceptor sites to conform to the structural requirements of the mok net.	Hydrogen	75-83	MOK protein kinase	Homo sapiens	163-166
31136867-2	2019	It is shown that the interaction of QDs with FIB is a spontaneous process and the major driving forces are van der Waals forces and hydrogen bonds.	Hydrogen	132-140	fibrinogen beta chain	Homo sapiens	45-48
31483550-6	2019	Moreover, H2 S decreased the levels of oxidative stress, the expression of pro-inflammatory factors including tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1) and interleukin 6 (IL-6), and the apoptosis of hepatocytes.	Hydrogen	10-12	tumor necrosis factor	Rattus norvegicus	139-148
31483550-6	2019	Moreover, H2 S decreased the levels of oxidative stress, the expression of pro-inflammatory factors including tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1) and interleukin 6 (IL-6), and the apoptosis of hepatocytes.	Hydrogen	10-12	interleukin 6	Rattus norvegicus	176-189
31483550-6	2019	Moreover, H2 S decreased the levels of oxidative stress, the expression of pro-inflammatory factors including tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1) and interleukin 6 (IL-6), and the apoptosis of hepatocytes.	Hydrogen	10-12	interleukin 6	Rattus norvegicus	191-195
31480789-5	2019	The thermodynamic parameters were obtained as DeltaH = -56.964 kJ/mol, DeltaS = -115.98 J/mol K. The main active interactions forming the tebuconazole/human serum albumin complex were identified as the interplay between hydrogen bonds and/or van der Waals forces, based on thermodynamic experiments.	Hydrogen	220-228	albumin	Homo sapiens	157-170
31419122-5	2019	Decay from S , or S1  and S2 , is rate-determined by radical rearrangement (1H) or by contributions from both radical rearrangement and hydrogen transfer (2H).	Hydrogen	76-78	proteasome 26S subunit, non-ATPase 1	Homo sapiens	18-28
31419122-5	2019	Decay from S , or S1  and S2 , is rate-determined by radical rearrangement (1H) or by contributions from both radical rearrangement and hydrogen transfer (2H).	Hydrogen	136-144	proteasome 26S subunit, non-ATPase 1	Homo sapiens	18-28
31480789-7	2019	Hydrogen bonding of tebuconazole with Arg222, Ala215 and Ala291 of human serum albumin played a relevant role in binding.	Hydrogen	0-8	albumin	Homo sapiens	73-86
31113708-2	2019	Under the optimized working volume ratio of 1:4, starch concentration of 7 g L-1 and initial pH of 7.0, the highest H2 production of 1643.5 mL L-1 and lipid yield of 515.6 mg L-1 were achieved.	Hydrogen	116-118	immunoglobulin kappa variable 1-16	Homo sapiens	77-80
31113708-2	2019	Under the optimized working volume ratio of 1:4, starch concentration of 7 g L-1 and initial pH of 7.0, the highest H2 production of 1643.5 mL L-1 and lipid yield of 515.6 mg L-1 were achieved.	Hydrogen	116-118	immunoglobulin kappa variable 1-16	Homo sapiens	143-146
31176938-3	2019	Using optimized media composition, continuous H2 production at 0.2 h-1 dilution rate, showed highest H2 production rate, H2 yield and biomass yield of 1020 +- 23 mL L-1 h-1, 2.8 +- 0.1 mols mol-1 reducing sugar and 1.2 +- 0.06 g L-1, respectively.	Hydrogen	46-48	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	190-195
31113708-2	2019	Under the optimized working volume ratio of 1:4, starch concentration of 7 g L-1 and initial pH of 7.0, the highest H2 production of 1643.5 mL L-1 and lipid yield of 515.6 mg L-1 were achieved.	Hydrogen	116-118	immunoglobulin kappa variable 1-16	Homo sapiens	143-146
31291611-7	2019	Molecular docking indicated potential interactions of demethylbellidifolin (1) with HCE 2 through two hydrogen bonds of the C-3 and C-5 hydroxy groups with amino acid residues Glu227 and Ser228 in the catalytic cavity, respectively.	Hydrogen	102-110	carboxylesterase 2	Homo sapiens	84-89
31212179-12	2019	MD result showed that CAP could steadily bind to HSA in the site I based on the formation of hydrogen bond and pi-pi stacking interaction in addition to hydrophobic force.	Hydrogen	93-101	albumin	Homo sapiens	49-52
31200337-0	2019	Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model.	Hydrogen	0-8	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	72-81
31247261-6	2019	Results of molecular docking suggest that PPD(R) yields more hydrogen bond interactions and a lower binding energy than its counterparts, resulting in tighter binding between PPD(R) and GR.	Hydrogen	61-69	nuclear receptor subfamily 3 group C member 1	Homo sapiens	186-188
30939252-0	2019	Involvement of the Akt-dependent CREB signaling pathway in hydrogen-peroxide-induced early growth response protein-1 expression in rat vascular smooth muscle cells 1.	Hydrogen	59-67	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
30939252-0	2019	Involvement of the Akt-dependent CREB signaling pathway in hydrogen-peroxide-induced early growth response protein-1 expression in rat vascular smooth muscle cells 1.	Hydrogen	59-67	early growth response 1	Rattus norvegicus	85-116
31200337-4	2019	This study is aimed to evaluate the beneficial effects of hydrogen gas inhalation on alveolar macrophage phagocytosis in an ovalbumin (OVA)-induced murine asthma model.	Hydrogen	58-66	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	124-133
31200337-11	2019	Concomitantly, hydrogen gas inhalation inhibited NF-kappaB activation and markedly activated Nrf2 pathway in OVA-induced asthmatic mice.	Hydrogen	15-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
31200337-12	2019	CONCLUSIONS: Our findings demonstrated that hydrogen gas inhalation enhanced alveolar macrophage phagocytosis in OVA-induced asthmatic mice, which may be associated with the antioxidant effects of hydrogen gas and the activation of the Nrf2 pathway.	Hydrogen	44-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	236-240
31276916-3	2019	Here we show that by ketohexokinase - the primary enzyme of fructose - is involved in regulation of renal sodium reabsorption and blood pressure via activation of the sodium hydrogen exchanger in renal proximal tubular cells.	Hydrogen	174-182	ketohexokinase	Mus musculus	21-35
30193557-4	2019	Analyses on hydrogen bond interactions show that the decrease in hydrogen bonding interactions of residues R126 and Y128 with three inhibitors and the increase in that of K58 with inhibitors ZGC and IBP in the R126A mutated systems mostly regulate the conformational changes of A-FABP.	Hydrogen	12-20	DEF6 guanine nucleotide exchange factor	Homo sapiens	199-202
30204055-9	2019	The hydrogen bonding of compounds with Asp1198, His1201, Tyr1203 in TNKS1 and Gly1032, Ser1068 in TNKS2 are the key interactions plays a major role in binding energy.	Hydrogen	4-12	tankyrase	Homo sapiens	68-73
31456057-8	2019	In the conventional simulations, the mutations destabilized the overall IGF-I structure by destroying two important hydrogen bonds within the key region of "C-neck."	Hydrogen	116-124	insulin like growth factor 1	Homo sapiens	72-77
31813875-3	2019	Series of new compounds were designed, synthesized and evaluated in this work, from which we identified 2-((4-(1,3-dioxoisoindolin-2-yl)benzyl)amino)-2-oxoethyl-2-(4-methoxyphenyl)acetate (1h) as a new dual cholinesterase and beta-secretase inhibitor without toxicity.	Hydrogen	189-191	acetylcholinesterase (Cartwright blood group)	Homo sapiens	207-221
31331936-4	2019	Here we investigate how the structural landscape of c-Src is shaped by nucleotide binding and phosphorylation of Tyr416 using biochemical experiments, hydrogen/deuterium exchange MS, and atomistic molecular simulations.	Hydrogen	151-159	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	52-57
31364628-1	2019	The hydrogen bond patterns, proton ordering, and phase transitions of monolayer ice in two-dimensional hydrophobic confinement are fundamentally different from those found for bulk ice.	Hydrogen	4-12	caspase 1	Homo sapiens	80-83
31398016-8	2019	Sequence alignment of LS with other CBS and OASS enzymes and inspection of the LS crystal structure in the external aldimine state with l-lanthionine reveal that LS possesses a unique loop that engages in hydrogen-bond contact with the product, providing a structural rationale for the enzyme"s catalytic preference for H2S and l-lanthionine biosynthesis.	Hydrogen	205-213	cystathionine beta-synthase	Homo sapiens	36-39
31213525-7	2019	Hydrogen-deuterium exchange MS (HDX-MS) of p38alpha performed at 33, 37, and 39.5  C indicated temperature-dependent conformational changes in an alpha helix near the common docking and glutamate:aspartate substrate-binding domains at the known binding site for MK2.	Hydrogen	0-8	mitogen-activated protein kinase 14	Homo sapiens	43-51
30767123-6	2019	Binding interaction analysis revealed that insulin entrapment is largely due to hydrogen bonding between the polymer matrix and insulin, and flooding the matrix with electrical charge likely disrupts the attractive forces that kept protein in place helping the release of the proteins.	Hydrogen	80-88	insulin	Homo sapiens	43-50
31241919-11	2019	In silico studies indicated hydrogen bonding, hydrophobic, and pi-pair (pi-pi, pi-sigma, and pi-cation) interactions between the complexes and EGFR/VEGFR2 kinase receptors.	Hydrogen	28-36	epidermal growth factor receptor	Homo sapiens	143-147
31063714-11	2019	According to the performed computational studies conducted, perezone showed the highest affinity to PARP-1 enzyme being this complex the most stable due to the presence of a small and deep cavity in the active site, which allows perezone to fit deeply by forming hydrogen bonds and hydrophobic interactions, which drive this interaction.	Hydrogen	263-271	poly(ADP-ribose) polymerase 1	Homo sapiens	100-106
31314528-2	2019	The structural analyses utilized gas electron diffraction supported by high-level quantum calculations, while the pathway for the unimolecular hydrogen release reaction in the absence and presence of BH3 as a bifunctional catalyst was predicted at the CBS-QB3 level.	Hydrogen	143-151	cystathionine beta-synthase	Homo sapiens	252-255
31314528-4	2019	The predicted enthalpy of dehydrogenation at the CCSD(T)/CBS level indicates that mild reaction conditions would be required for hydrogen release and that the compound is closer to thermoneutral than linear amine boranes.	Hydrogen	28-36	cystathionine beta-synthase	Homo sapiens	57-60
31197422-4	2019	The results showed that tetrandrine had a high possibility of binding to the N-myc and Bcl-2 G-quadruplexes through hydrogen bonding, whereas the possibility of binding of isotetrandrine was low and it seemed to have no possibility of forming hydrogen bonds.	Hydrogen	116-124	BCL2 apoptosis regulator	Homo sapiens	87-92
31004951-3	2019	Without any clogging events at high ISR of 10%, LBR-F achieved significantly higher (p &lt; 0.05) VS removal of 91%, hydrolysis yield of 837 g cumulative sCOD/kg volatile solids (VS), and VFA yield of 669 g COD/kg VS. Hydrogen yield was as high as 20 m3/ton food waste in LBR-F.	Hydrogen	218-226	lamin B receptor	Homo sapiens	48-53
31100281-5	2019	Docking studies revealed that the quinoline group within the AChE active site was positioned in the choline binding site, while the C(4)-amino group substituents, depending on their lipophilicity, could establish hydrogen bonds or pi-interactions with residues of the peripheral anionic site.	Hydrogen	213-221	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-65
31431619-8	2019	Docking and biacore experiments revealed that STAT3 is the target protein of PPD, which formed hydrogen bonds with Gly583/Leu608/Tyr674 at the SH2 domain of STAT3.	Hydrogen	95-103	signal transducer and activator of transcription 3	Homo sapiens	46-51
31431619-8	2019	Docking and biacore experiments revealed that STAT3 is the target protein of PPD, which formed hydrogen bonds with Gly583/Leu608/Tyr674 at the SH2 domain of STAT3.	Hydrogen	95-103	signal transducer and activator of transcription 3	Homo sapiens	157-162
31456911-8	2019	The increased phosphorylated levels of extracellular signal-regulated kinase (ERK) but not cAMP response element binding protein (CREB) or Akt were observed 1h after NMDA injection in both the vehicle- and CV-treated rats; however, pERK activation was no more upregulated at 3h after NMDA injection.	Hydrogen	157-159	Eph receptor B1	Rattus norvegicus	39-76
31456911-8	2019	The increased phosphorylated levels of extracellular signal-regulated kinase (ERK) but not cAMP response element binding protein (CREB) or Akt were observed 1h after NMDA injection in both the vehicle- and CV-treated rats; however, pERK activation was no more upregulated at 3h after NMDA injection.	Hydrogen	157-159	Eph receptor B1	Rattus norvegicus	78-81
31314511-8	2019	Interestingly, one such swap generated a scFv with especially low aggregation rates under low/high ionic strengths and denaturing buffers; molecular modeling identified hydrogen bonding between the arginine side chain and main chain peptide groups, stabilizing the structure.	Hydrogen	169-177	immunglobulin heavy chain variable region	Homo sapiens	41-45
31460469-4	2019	For the complex, the O   H hydrogen bond was popular in the intermolecular interactions, and dispersion interaction played an essential role, especially in Cx/CL-20 multimolecular complexes.	Hydrogen	27-35	epithelial membrane protein 1	Homo sapiens	159-164
31440160-0	2019	H2 Protects Against Lipopolysaccharide-Induced Cardiac Dysfunction via Blocking TLR4-Mediated Cytokines Expression.	Hydrogen	0-2	toll-like receptor 4	Mus musculus	80-84
31440160-13	2019	Furthermore, pretreatment with hydrogen resulted in cardioprotection during septic cardiomyopathy via inhibiting the expression of pro-inflammatory cytokines TNFalpha, IL-1beta, and IL-18; suppressing the phosphorylation of ERK1/2, p38, and JNK; and reducing the nuclear translocation of NF-kappaB and the expression of TLR4 by LPS.	Hydrogen	31-39	tumor necrosis factor	Mus musculus	158-166
31440160-13	2019	Furthermore, pretreatment with hydrogen resulted in cardioprotection during septic cardiomyopathy via inhibiting the expression of pro-inflammatory cytokines TNFalpha, IL-1beta, and IL-18; suppressing the phosphorylation of ERK1/2, p38, and JNK; and reducing the nuclear translocation of NF-kappaB and the expression of TLR4 by LPS.	Hydrogen	31-39	interleukin 1 beta	Mus musculus	168-176
31440160-13	2019	Furthermore, pretreatment with hydrogen resulted in cardioprotection during septic cardiomyopathy via inhibiting the expression of pro-inflammatory cytokines TNFalpha, IL-1beta, and IL-18; suppressing the phosphorylation of ERK1/2, p38, and JNK; and reducing the nuclear translocation of NF-kappaB and the expression of TLR4 by LPS.	Hydrogen	31-39	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	288-297
31440160-13	2019	Furthermore, pretreatment with hydrogen resulted in cardioprotection during septic cardiomyopathy via inhibiting the expression of pro-inflammatory cytokines TNFalpha, IL-1beta, and IL-18; suppressing the phosphorylation of ERK1/2, p38, and JNK; and reducing the nuclear translocation of NF-kappaB and the expression of TLR4 by LPS.	Hydrogen	31-39	toll-like receptor 4	Mus musculus	320-324
31440160-14	2019	Conclusion and Implications: Hydrogen therapy prevents LPS-induced cardiac dysfunction in part via downregulation of TLR4-mediated pro-inflammatory cytokines expression.	Hydrogen	29-37	toll-like receptor 4	Mus musculus	117-121
31089833-3	2019	Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus.	Hydrogen	0-8	mixed lineage kinase domain like pseudokinase	Rattus norvegicus	89-93
31089833-3	2019	Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus.	Hydrogen	0-8	mixed lineage kinase domain like pseudokinase	Rattus norvegicus	110-114
30079808-3	2019	A 3D QSAR study based on comparative molecular field analysis and comparative molecular similarity analysis (CoMSIA) discerned that a SSTR2 ligand with electronegative, less-bulkier, and hydrogen atom donating/accepting substitutions is important for their biological activity.	Hydrogen	187-195	somatostatin receptor 2	Homo sapiens	134-139
31300922-2	2019	The interaction of the organometallic complexes of Ru(eta6-p-cymene) and Rh(eta5-C5Me5) with human serum albumin (HSA) was studied in detail by a combination of various methods such as ultrafiltration, capillary electrophoresis, 1H NMR spectroscopy, fluorometry and UV-visible spectrophotometry in the presence of 100 mM chloride ions.	Hydrogen	229-231	albumin	Homo sapiens	99-112
31145948-8	2019	The hydrogen interaction between HP-beta-CD and HA restricted the mobility of the molecular chains, and subsequently increased the elastic modulus of the complex materials.	Hydrogen	4-12	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	36-43
31256283-8	2019	The molecular docking suggests that the NO derivatives bind into the upper body domain of the P2X7 pore and that the main intermolecular interaction with the two most active NO derivatives occur with the residues Phe 95, 103 and 293 by hydrophobic interactions and with Leu97, Gln98 and Ser101 by hydrogen bonds..	Hydrogen	297-305	purinergic receptor P2X 7	Homo sapiens	94-98
31085520-9	2019	Moreover, GRL-057-14"s P1-bis-fluoro-methylbenzene forms strong hydrogen bonding and effective van der Waals interactions.	Hydrogen	64-72	nuclear receptor subfamily 3 group C member 1	Homo sapiens	10-13
31357694-0	2019	The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela Cancer cells have an unusual regulation of hydrogen ion dynamics that are driven by poor vascularity perfusion, regional hypoxia, and increased glycolysis.	Hydrogen	171-179	solute carrier family 9 member A1	Homo sapiens	12-39
31173012-8	2019	The WTMtD simulations further reveal that the bridged water molecules are more ordered near the catalytic triad of AChE to deter the nucleophilicity of Ser203 through intermolecular hydrogen bonding when donepezil approaches near to the active site gorge of AChE.	Hydrogen	182-190	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-119
31244039-3	2019	The resultant ANF/AgNW nanocomposite papers present ultraflexibility, extremely low sheet resistance (minimum Rs of 0.12 Omega/sq), and outstanding heat resistance (thermal degradation temperature above 500  C) and mechanical properties (tensile strength of 285.7 MPa, tensile modulus of 6.51 GPa with a AgNW area fraction of 0.4 g/m2), benefiting from the partial embedding of AgNWs into the ANF substrate and the extensive hydrogen-bonding interactions.	Hydrogen	425-433	natriuretic peptide A	Homo sapiens	14-17
31340575-6	2019	Furthermore, LSGYGP significantly decreased Ang II-induced DNA damage in a comet assay, and molecular docking results showed that the steady interaction between LSGYGP with NF-kappaB may be attributed to hydrogen bonds.	Hydrogen	204-212	angiotensinogen	Homo sapiens	44-50
31340575-6	2019	Furthermore, LSGYGP significantly decreased Ang II-induced DNA damage in a comet assay, and molecular docking results showed that the steady interaction between LSGYGP with NF-kappaB may be attributed to hydrogen bonds.	Hydrogen	204-212	nuclear factor kappa B subunit 1	Homo sapiens	173-182
31319625-8	2019	Based on our data, the cut-off value for LM diagnosis (25 ppm H2) using AIRE is 3.0 AU and it is effective for the identification of a response to lactose-containing foods in individuals experiencing LM, although its upper limit is only 81 ppm.	Hydrogen	62-64	autoimmune regulator	Homo sapiens	72-76
31208986-3	2019	1H nuclear magnetic resonance-based metabolomics was applied to explore the altered metabolic pattern in Pdk1-deficient mice.	Hydrogen	0-2	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	105-109
31173012-8	2019	The WTMtD simulations further reveal that the bridged water molecules are more ordered near the catalytic triad of AChE to deter the nucleophilicity of Ser203 through intermolecular hydrogen bonding when donepezil approaches near to the active site gorge of AChE.	Hydrogen	182-190	acetylcholinesterase (Cartwright blood group)	Homo sapiens	258-262
31144813-3	2019	During the self-assembly of TMB molecules, the antibody as signal recognition units and bovine serum albumin as the stabilizing agents could be accommodated simultaneously through hydrogen-bonding and van der Waals interactions to form all-inclusive signal tags, which can avoid the complex cross-linking procedures.	Hydrogen	180-188	albumin	Homo sapiens	95-108
30958921-5	2019	This Minireview provides a short overview of the major progress made in this field for C-H functionalization at sp2 and sp3 carbon centers with different transient working modes, including covalent, hydrogen, and ionic bonds.	Hydrogen	199-207	Sp2 transcription factor	Homo sapiens	112-115
30958921-5	2019	This Minireview provides a short overview of the major progress made in this field for C-H functionalization at sp2 and sp3 carbon centers with different transient working modes, including covalent, hydrogen, and ionic bonds.	Hydrogen	199-207	Sp3 transcription factor	Homo sapiens	120-123
30919764-4	2019	The phosphorylation-induced structural change was visualized by overlapping a well dispersed 15N-1H heteronuclear single quantum coherence (HSQC) NMR spectroscopy between EEE-BCL-2-EK (62-206) and BCL-2.	Hydrogen	97-99	BCL2 apoptosis regulator	Homo sapiens	175-180
31284641-6	2019	This new conformation is modulated by the irregularly structured C-terminal tail when it first recognizes and binds to ERK2 at the d-peptide recruitment site (DRS) in an allosteric manner, and is facilitated by the rearrangement of the surface electrostatic and hydrogen-bonding interactions on the DED.	Hydrogen	262-270	mitogen-activated protein kinase 1	Homo sapiens	119-123
31262887-7	2019	In particular, derivatives 1g and 1h inhibited both proliferation and migration of SUIT-2 cells at concentrations lower than 10 muM.	Hydrogen	34-36	latexin	Homo sapiens	128-131
31104815-2	2019	Here, we use hydrogen/deuterium exchange mass spectrometry to investigate the conformational response of sortilin to binding biological ligands including the peptides neurotensin and the sortilin propeptide and the proteins progranulin and pro-nerve growth factor-beta.	Hydrogen	13-21	sortilin 1	Homo sapiens	105-113
31083022-0	2019	Hydrogen gas protects against ovariectomy-induced osteoporosis by inhibiting NF-kappaB activation.	Hydrogen	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	77-86
30927279-14	2019	Taken together, exogenous H2 S supplementary accelerated the skin wound healing, which might be related to oxidative stress inhibition and VEGF enhancement.	Hydrogen	26-28	vascular endothelial growth factor A	Homo sapiens	139-143
29400109-6	2019	These 1H-MRS data underscore a pattern of neurochemical alterations that are specific to brain regions and to disease stages of the G93A-SOD1 mouse model.	Hydrogen	6-8	superoxide dismutase 1, soluble	Mus musculus	137-141
31247845-1	2019	Several paramagnetic Co(II) and Fe(II) macrocyclic complexes were prepared with the goal of introducing a bound water ligand to produce paramagnetically shifted water 1H resonances and for paramagnetic chemical exchange saturation transfer (paraCEST) applications.	Hydrogen	167-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
31247845-9	2019	Notably, the Co(II) and Fe(II) complexes presented here produced substantial paramagnetic shifts of bulk water 1H resonances, independent of having an inner-sphere water.	Hydrogen	111-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
31083022-17	2019	H2 markedly inhibited RANKL-induced activation, nuclear translocation, and transcriptional activity of NF-kappaB (P &lt; 0.05, RANKL+H2 vs RANKL).	Hydrogen	0-2	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	103-112
31083022-17	2019	H2 markedly inhibited RANKL-induced activation, nuclear translocation, and transcriptional activity of NF-kappaB (P &lt; 0.05, RANKL+H2 vs RANKL).	Hydrogen	133-135	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	103-112
29847499-0	2019	Hydrogen-Rich Saline Attenuates Acute Lung Injury Induced by Limb Ischemia/Reperfusion via Down-Regulating Chemerin and NLRP3 in Rats.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	120-125
31270472-4	2019	We show that hydrogen bonding, pi/sp2, and hydrophobic interactions all contribute to stabilizing LLPS of FUS LC.	Hydrogen	13-21	FUS RNA binding protein	Homo sapiens	106-109
30887599-5	2019	Computational docking indicated that epimagnolin targeted an active pocket of the mTOR kinase domain by forming three hydrogen bonds and three hydrophobic interactions.	Hydrogen	118-126	mechanistic target of rapamycin kinase	Homo sapiens	82-86
29847499-2	2019	The hypothesis of this study is that hydrogen-rich solution could attenuateacute lung injury and improve mortality via chemerin and NLRP3 after LI/R in rats.	Hydrogen	37-45	NLR family, pyrin domain containing 3	Rattus norvegicus	132-137
31041807-4	2019	The chemistry essence of this strategy lies in the mechanical-force-driven assembly, during which tannin-metal (Zn2+ and Ru3+ ) coordination polymerization and hydrogen-bonding interactions between tannin-block copolymer (PEO-PPO-PEO, F127) simultaneously occur.	Hydrogen	160-168	protoporphyrinogen oxidase	Homo sapiens	226-229
31441411-0	2019	[Effects of hydrogen on lung injury in wild-type and Nrf2 gene knockout mice: relationship with Nrf2/HO-1/HMGB1 pathway].	Hydrogen	12-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100
31441411-0	2019	[Effects of hydrogen on lung injury in wild-type and Nrf2 gene knockout mice: relationship with Nrf2/HO-1/HMGB1 pathway].	Hydrogen	12-20	heme oxygenase 1	Mus musculus	101-105
31441411-15	2019	CONCLUSIONS: H2 inhibits lung injury in septic mice through Nrf2/HO-1/HMGB1 pathway.	Hydrogen	13-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	60-64
31441411-15	2019	CONCLUSIONS: H2 inhibits lung injury in septic mice through Nrf2/HO-1/HMGB1 pathway.	Hydrogen	13-15	heme oxygenase 1	Mus musculus	65-69
31441411-16	2019	Nrf2 plays a major role in the treatment of septic lung injury by H2.	Hydrogen	66-68	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
31066954-0	2019	The Effect of Thermal Treatment on the Hydrogen-Storage Properties of PIM-1.	Hydrogen	39-47	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	70-75
31242623-5	2019	The combination of the 19F with standard proton saturation transfer difference (1H-STD-NMR) data, assisted by molecular dynamics (MD) simulations, permits us to successfully define this new binding epitope, where Man coordinates a Ca2+ ion of the lectin carbohydrate recognition domain (CRD) through the axial OH-2 and equatorial OH-3 groups, thus mimicking the Fuc/DC-SIGN binding architecture.	Hydrogen	80-82	CD209 molecule	Homo sapiens	366-373
31316725-4	2019	After the AptEpA/EpCAM complex had equilibrated with the water environment through a molecular dynamics simulation at 300 K for 10 ns, stable hydrogen bonds formed between the bases of AptEpA and EpCAM residues of the secondary structures, which included the alpha helix and beta sheet becoming less stable in the water environment.	Hydrogen	142-150	epithelial cell adhesion molecule	Homo sapiens	17-22
31316725-4	2019	After the AptEpA/EpCAM complex had equilibrated with the water environment through a molecular dynamics simulation at 300 K for 10 ns, stable hydrogen bonds formed between the bases of AptEpA and EpCAM residues of the secondary structures, which included the alpha helix and beta sheet becoming less stable in the water environment.	Hydrogen	142-150	epithelial cell adhesion molecule	Homo sapiens	196-201
31316725-5	2019	Those hydrogen bonds formed between the bases of AptEpA and EpCAM loop fragment residues remained stable in the water environment.	Hydrogen	6-14	epithelial cell adhesion molecule	Homo sapiens	60-65
31066954-3	2019	The synthesised PIM-1 was annealed at different temperatures for varying times and then characterised for hydrogen uptake at both ambient and cryogenic temperatures.	Hydrogen	106-114	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	16-21
30925335-5	2019	A single binding site was predicted for AtGSTF8 towards cadmium ions and the van der Walls interactions and hydrogen bonds are the major driving forces of the interaction.	Hydrogen	108-116	glutathione S-transferase phi 8	Arabidopsis thaliana	40-47
30927596-5	2019	Rh0, Ru0 and Pd0 nanoparticles on activated carbon provide a turnover frequency value of 188 min-1, 235 min-1 and 40 min-1, respectively, at 25.0 +- 0.1  C. They preserve their activity even after multiple use in H2 generation from the hydrolysis of ammonia borane.	Hydrogen	213-215	CD59 molecule (CD59 blood group)	Homo sapiens	104-122
31135801-5	2019	Here, by a "best-match for hydrogen-bonding pair" (BMHP) computational protocol and molecular dynamics (MD) simulations, we model the atomic structure of KRas4B in complex with the Ras binding domain (RBD) of PI3Kalpha, striving to understand the mechanism of PI3Kalpha activation by Ras.	Hydrogen	27-35	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	209-218
30828836-0	2019	U-shaped caveolin-1 conformations are tightly regulated by hydrogen bonds with lipids.	Hydrogen	59-67	caveolin 1	Homo sapiens	9-19
30828836-3	2019	RB-Cav1s contain one or two lipids residing between the helices that are hydrogen bonded (h-bonded) to both helices in a multidentate fashion.	Hydrogen	73-81	caveolin 1	Homo sapiens	3-7
31157332-0	2019	Small-pore CAU-21 and porous PIM-1 in mixed-matrix membranes for improving selectivity and permeability in hydrogen separation.	Hydrogen	107-115	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	29-34
31084022-4	2019	Emphasis is placed on how ligand design and exploration of fundamental organometallic chemistry coupled with mechanistic understanding have been used to discover iron catalysts for the hydrogen isotope exchange in pharmaceuticals and cobalt catalysts for C(sp2)-H borylation reactions.	Hydrogen	185-193	Sp2 transcription factor	Homo sapiens	255-260
31064182-4	2019	The complexes [Ru(Por)(QC)] were prepared from reaction of [Ru(Por)(CO)] with diazo quinones and exhibited dual reactivity, i.e., hydrogen atom transfer (HAT) as well as QC transfer.	Hydrogen	130-138	cytochrome p450 oxidoreductase	Homo sapiens	18-21
31064182-4	2019	The complexes [Ru(Por)(QC)] were prepared from reaction of [Ru(Por)(CO)] with diazo quinones and exhibited dual reactivity, i.e., hydrogen atom transfer (HAT) as well as QC transfer.	Hydrogen	130-138	cytochrome p450 oxidoreductase	Homo sapiens	63-66
32830652-8	2019	The results revealed that the O-H...O hydrogen bonding interaction between the phenolic hydroxyl group of TNP and nitro groups of CL-20, as well as nitro...pi, nitro...nitro and ONO2...pi(N)NO2 interactions, based on the benzene ring and nitro groups, are the main interactions occurring in the cocrystal.	Hydrogen	38-46	epithelial membrane protein 1	Homo sapiens	130-135
30958620-2	2019	Herein, we describe a mechanistic phenomenon for the activation and spillover of hydrogen for remarkable selectivity in the semi-hydrogenation of acetylene over sub-1 nm Pd nanoclusters confined within sodalite (SOD) zeolite (Pd@SOD).	Hydrogen	81-89	SUB1 regulator of transcription	Homo sapiens	161-166
31165758-7	2019	Molecular dynamics simulation results showed that this polymorphic variant of APOA5 has a different hydrogen bond network, increased average distance between chains, and an ability to form distinct clusters.	Hydrogen	100-108	apolipoprotein A5	Homo sapiens	78-83
30958620-0	2019	Activation and Spillover of Hydrogen on Sub-1 nm Palladium Nanoclusters Confined within Sodalite Zeolite for the Semi-Hydrogenation of Alkynes.	Hydrogen	28-36	SUB1 regulator of transcription	Homo sapiens	40-45
30974297-13	2019	Molecular docking indicated that Thalpha1 interacted with ACE enzyme (N- and C-domains) due to electrostatic, hydrophobic, and hydrogen forces.	Hydrogen	127-135	angiotensin I converting enzyme	Homo sapiens	58-61
30952061-5	2019	Molecular modeling simulation revealed that, the designed compounds docked well into PARP-1 active site and their complexes are stabilized by three key hydrogen bond interactions with both Gly863 and Ser904 as well as other favorable pi-pi and hydrogen-pi stacking interactions with Tyr907 and Tyr896, respectively.	Hydrogen	152-160	poly(ADP-ribose) polymerase 1	Homo sapiens	85-91
30884308-7	2019	Molecular docking studies suggested that the benzothiazepinones evaluated here consistently display hydrogen bonding with Ser214 of thrombin, which is similar to that of the co-crystallized ligand (1-(2R)-2-amino-3-phenyl-propanoyl-N-(2,5dichlorophenyl)methylpyrrolidine-2-carboxamide).	Hydrogen	100-108	coagulation factor II, thrombin	Homo sapiens	132-140
31112822-6	2019	It was found that loss in either of the hydrogen bond (H-bond) contacts (MeV-H:481-CD46:65, MeV-H:546-CD46:63) in the central contact region prevented efficient CD46 binding.	Hydrogen	40-48	CD46 molecule	Homo sapiens	83-87
30952061-5	2019	Molecular modeling simulation revealed that, the designed compounds docked well into PARP-1 active site and their complexes are stabilized by three key hydrogen bond interactions with both Gly863 and Ser904 as well as other favorable pi-pi and hydrogen-pi stacking interactions with Tyr907 and Tyr896, respectively.	Hydrogen	244-252	poly(ADP-ribose) polymerase 1	Homo sapiens	85-91
31112822-6	2019	It was found that loss in either of the hydrogen bond (H-bond) contacts (MeV-H:481-CD46:65, MeV-H:546-CD46:63) in the central contact region prevented efficient CD46 binding.	Hydrogen	40-48	CD46 molecule	Homo sapiens	102-106
31112822-6	2019	It was found that loss in either of the hydrogen bond (H-bond) contacts (MeV-H:481-CD46:65, MeV-H:546-CD46:63) in the central contact region prevented efficient CD46 binding.	Hydrogen	40-48	CD46 molecule	Homo sapiens	102-106
30947639-4	2019	In this article, BSA was treated with urea and glutathione to prepare bovine serum albumin hydrogel controlled by two dynamic equilibrium bonds (disulfide and hydrogen bonds).	Hydrogen	159-167	albumin	Homo sapiens	77-90
30877875-0	2019	Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner.	Hydrogen	0-8	FUN14 domain containing 1	Mus musculus	68-74
30317599-0	2019	Muon disrupts AKT hydrogen bond network in cancer.	Hydrogen	18-26	AKT serine/threonine kinase 1	Homo sapiens	14-17
31067044-3	2019	Current protocol leverages a C-3 axial sulfonamide group in 3,5- trans-3-ADSs as a hydrogen-bond (H-bond) donor and repurposes substoichiometric phosphine oxide as an exogenous nucleophilic reagent (exNu) to establish an intramolecular H-bond between the former and the derived alpha-oxyphosphonium ion.	Hydrogen	83-91	adenylosuccinate synthase 2	Homo sapiens	73-77
30317599-6	2019	Thus, muon beam, muonic atom, muon neutrino shower, and electrons simultaneously cause fast neutralization of the AKT hydrogen bond network by the conversion of hydrogen into deuterium or helium, inactivating the hydrogen bond networks and inducing failure of cancer complexity and robustness with the disappearance of a malignant phenotype.	Hydrogen	118-126	AKT serine/threonine kinase 1	Homo sapiens	114-117
30317599-6	2019	Thus, muon beam, muonic atom, muon neutrino shower, and electrons simultaneously cause fast neutralization of the AKT hydrogen bond network by the conversion of hydrogen into deuterium or helium, inactivating the hydrogen bond networks and inducing failure of cancer complexity and robustness with the disappearance of a malignant phenotype.	Hydrogen	161-169	AKT serine/threonine kinase 1	Homo sapiens	114-117
30317599-6	2019	Thus, muon beam, muonic atom, muon neutrino shower, and electrons simultaneously cause fast neutralization of the AKT hydrogen bond network by the conversion of hydrogen into deuterium or helium, inactivating the hydrogen bond networks and inducing failure of cancer complexity and robustness with the disappearance of a malignant phenotype.	Hydrogen	161-169	AKT serine/threonine kinase 1	Homo sapiens	114-117
31315738-1	2019	OBJECTIVE: To explore the protective effect of hydrogen-rich water on the oxidative stress injury of astrocytes in mice and its effect on phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) signal pathway.	Hydrogen	47-55	thymoma viral proto-oncogene 1	Mus musculus	191-194
31315738-15	2019	CONCLUSIONS: Hydrogen-rich water activates the PI3K/Akt pathway, thereby mediates mice astrocytes to exert the biological function of antioxidant.	Hydrogen	13-21	thymoma viral proto-oncogene 1	Mus musculus	52-55
31046224-5	2019	Such enhanced separation behavior is supposed to stem from the densified membrane microstructure induced by the strong intermolecular interactions between PIM-1 and PDASS (i.e., charge transfer, pi-pi stacking, and hydrogen bonding).	Hydrogen	215-223	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	155-160
31127106-2	2019	External perturbations such as pH and hydrogen bonding can also trigger the spin state transition of hemes through deprotonated histidine (e.g. Cytochrome c).	Hydrogen	38-46	cytochrome c, somatic	Homo sapiens	144-156
30879296-1	2019	A theoretical study has been carried out at the M062X/6-311++G(d,p) computational level to search for a rationale on ligands" affinity toward alpha2-adrenoceptors by estimating the nature and strength of intramolecular hydrogen bonds potentially formed (by means of the QTAIM and NBO approaches) as well as the degree of deviation from planarity that could be observed in some of the compounds.	Hydrogen	219-227	glycoprotein hormone subunit alpha 2	Homo sapiens	142-148
31086923-2	2019	The FH (vinylene) hydrogen bonds lock the backbone conformation and greatly improve the transistor performance of F2-QBTTE.	Hydrogen	18-26	coagulation factor II, thrombin	Homo sapiens	114-122
31100914-8	2019	Docking analysis showed that CSBp5 occupied the substrate-binding channel of ACE and interacted with ACE via hydrogen bonds.	Hydrogen	109-117	angiotensin I converting enzyme	Rattus norvegicus	101-104
31042379-4	2019	Molecular dynamics simulations suggest that the difference in G protein efficacy and beta-arrestin recruitment of the hybrid ( S)-22, the full agonist epinephrine, and the beta2-selective, G protein-biased partial agonist salmeterol depends on specific hydrogen bonding between Ser5.46 and Asn6.55, and the aromatic head group of the ligands.	Hydrogen	253-261	G protein-coupled receptor 162	Homo sapiens	172-177
30884075-4	2019	When the resulting CoII -H species was exposed to N2 , H2 evolution readily occurs at ambient conditions.	Hydrogen	55-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
31097667-3	2019	Here, we introduce one such transformation: the hydrodealkenylative cleavage of C(sp3)-C(sp2) bonds, conducted below room temperature, using ozone, an iron salt, and a hydrogen atom donor.	Hydrogen	168-176	Sp2 transcription factor	Homo sapiens	87-92
30843647-1	2019	Modification of magnesium diboride, MgB2 , by mechanical milling with THF, MgH2 , and/or Mg results in a lowering of the conditions required for its direct, bulk hydrogenation to magnesium borohydride, Mg(BH4 )2 , by 300 bar and 100  C. Following mechanical milling with MgH2 or THF and Mg, MgB2 can be hydrogenated to Mg(BH4 )2 at 300  C under 700 bar of H2 while achieving ~54-71 % conversion to the borohydride.	Hydrogen	77-79	secretoglobin family 2A member 1	Homo sapiens	36-40
30843647-1	2019	Modification of magnesium diboride, MgB2 , by mechanical milling with THF, MgH2 , and/or Mg results in a lowering of the conditions required for its direct, bulk hydrogenation to magnesium borohydride, Mg(BH4 )2 , by 300 bar and 100  C. Following mechanical milling with MgH2 or THF and Mg, MgB2 can be hydrogenated to Mg(BH4 )2 at 300  C under 700 bar of H2 while achieving ~54-71 % conversion to the borohydride.	Hydrogen	77-79	secretoglobin family 2A member 1	Homo sapiens	291-295
30843647-2	2019	The discovery of a means of dramatically lowering the conditions required for the hydrogenation of MgB2 is an important step towards the development of a practical onboard hydrogen storage system based on hydrogen cycling between Mg(BH4 )2 and MgB2 .	Hydrogen	82-90	secretoglobin family 2A member 1	Homo sapiens	99-103
30843647-2	2019	The discovery of a means of dramatically lowering the conditions required for the hydrogenation of MgB2 is an important step towards the development of a practical onboard hydrogen storage system based on hydrogen cycling between Mg(BH4 )2 and MgB2 .	Hydrogen	82-90	secretoglobin family 2A member 1	Homo sapiens	244-248
30843647-2	2019	The discovery of a means of dramatically lowering the conditions required for the hydrogenation of MgB2 is an important step towards the development of a practical onboard hydrogen storage system based on hydrogen cycling between Mg(BH4 )2 and MgB2 .	Hydrogen	172-180	secretoglobin family 2A member 1	Homo sapiens	99-103
30843647-2	2019	The discovery of a means of dramatically lowering the conditions required for the hydrogenation of MgB2 is an important step towards the development of a practical onboard hydrogen storage system based on hydrogen cycling between Mg(BH4 )2 and MgB2 .	Hydrogen	172-180	secretoglobin family 2A member 1	Homo sapiens	244-248
30843647-4	2019	The ability to activate the MgB2 through the introduction of structural defects transcends its relevance to hydrogen storage, as a method of overcoming its chemical inertness provides the key to harnessing other interesting properties of this material.	Hydrogen	108-116	secretoglobin family 2A member 1	Homo sapiens	28-32
30887646-3	2019	In particular, the Pd-H system is a simple and classical metal-hydrogen system, providing a platform suitable for a thorough understanding of ways of controlling the hydrogen-storage properties of materials.	Hydrogen	63-71	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	19-23
30887646-3	2019	In particular, the Pd-H system is a simple and classical metal-hydrogen system, providing a platform suitable for a thorough understanding of ways of controlling the hydrogen-storage properties of materials.	Hydrogen	166-174	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	19-23
31157201-5	2019	These results suggest that hydrogen bonding interactions between the nitrogens of the pyrazine ring and the SLC35F2 protein are critical for entry of YM155 into hPSCs, and hence stemotoxic activity.	Hydrogen	27-35	solute carrier family 35 member F2	Homo sapiens	108-115
31157201-4	2019	We found that a hydrogen bond acceptor in the pyrazine ring of YM155 derivatives is critical for stemotoxic activity, which is completely lost in hESCs lacking SLC35F2, which encodes a solute carrier protein.	Hydrogen	16-24	solute carrier family 35 member F2	Homo sapiens	160-167
30715728-3	2019	Remarkably, a significant blueshift of Csp2 -H bond by 81-96 cm-1 in the Csp2 -H   O hydrogen bond has hardly ever been reported, and a considerable redshift of O-H stretching frequency by 206-544 cm-1 in the O-H   O/S hydrogen bonds is also predicted.	Hydrogen	85-93	regulator of calcineurin 2	Homo sapiens	39-43
30715728-3	2019	Remarkably, a significant blueshift of Csp2 -H bond by 81-96 cm-1 in the Csp2 -H   O hydrogen bond has hardly ever been reported, and a considerable redshift of O-H stretching frequency by 206-544 cm-1 in the O-H   O/S hydrogen bonds is also predicted.	Hydrogen	85-93	regulator of calcineurin 2	Homo sapiens	73-77
30852283-6	2019	The results showed that the complex of TP/TB and SOD with 1:1 component was stabilized by hydrogen bonding and van der Waals forces.	Hydrogen	90-98	superoxide dismutase 1	Homo sapiens	49-52
30862565-6	2019	Hydrogen-deuterium exchange mass spectrometry (HDX-MS) demonstrated that the Y340A mutation attenuated deuterium suppression of Reptin in this motif in the presence of ligand.	Hydrogen	0-8	RuvB like AAA ATPase 2	Homo sapiens	128-134
30716685-4	2019	We found that the hydrogen bond network of proteins (three states of EGFR) was affected by Tubemoside.	Hydrogen	18-26	epidermal growth factor receptor	Homo sapiens	69-73
31006511-8	2019	In comparison, the average RA h2 captured by compared CD4+ T histone marks is 42.3% and by CD4+ T specifically expressed gene sets is 36.4%.	Hydrogen	30-32	CD4 molecule	Homo sapiens	54-57
30637977-4	2019	The results demonstrate that Ser119 in CYP3A4 and Glu374 in CYP3A5 formed direct hydrogen bonding with SE, respectively.	Hydrogen	81-89	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	39-45
30637977-4	2019	The results demonstrate that Ser119 in CYP3A4 and Glu374 in CYP3A5 formed direct hydrogen bonding with SE, respectively.	Hydrogen	81-89	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	60-66
30637977-5	2019	Additionally, one water molecule located between the B-C loop and the I helix mediated different hydrogen-bonding networks between CYP3A4/3A5 and SE.	Hydrogen	97-105	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	131-137
30898641-5	2019	MTX consists of aromatic rings (hydrophobic part) and two amino-groups and two hydroxyl-groups (hydrophilic part) with planar structure, which could interact with PPa via pi-pi stacking, hydrophobic interactions, intermolecular hydrogen bonding and electrostatic interactions.	Hydrogen	228-236	preproenkephalin	Mus musculus	163-166
30826710-3	2019	The results evaluated by FMO highlight some key interactions between InhA and the derivatives, indicating that the most potent derivative has strong hydrogen bonds with the Met98 side chain of InhA and strong electrostatic interactions with the nicotinamide adenine dinucleotide cofactor.	Hydrogen	149-157	inhibin subunit alpha	Homo sapiens	69-73
30826710-3	2019	The results evaluated by FMO highlight some key interactions between InhA and the derivatives, indicating that the most potent derivative has strong hydrogen bonds with the Met98 side chain of InhA and strong electrostatic interactions with the nicotinamide adenine dinucleotide cofactor.	Hydrogen	149-157	inhibin subunit alpha	Homo sapiens	193-197
31098413-4	2019	Here, we demonstrate that in a spider visual rhodopsin, orthologue of mammal melanopsins relevant to circadian rhythms, the Glu181 counterion functions likely by forming a hydrogen-bonding network, where Ser186 is a key mediator of the Glu181-SB interaction.	Hydrogen	172-180	rhodopsin	Homo sapiens	45-54
31193135-1	2019	Iduronate-2-sulfatase (IDS) is a lysosomal enzyme involved in the metabolism of the glycosaminoglycans heparan (HS) and dermatan (DS) sulfate.	Hydrogen	112-114	iduronate 2-sulfatase	Mus musculus	0-21
31193135-1	2019	Iduronate-2-sulfatase (IDS) is a lysosomal enzyme involved in the metabolism of the glycosaminoglycans heparan (HS) and dermatan (DS) sulfate.	Hydrogen	112-114	iduronate 2-sulfatase	Mus musculus	23-26
30338662-6	2019	The hydrogen production rate in a large PEM-PEC cell (16 cm2 ) was 10 mumol min-1 .	Hydrogen	4-12	CD59 molecule (CD59 blood group)	Homo sapiens	76-81
30973014-3	2019	Systematic changes in MOF 13C NMR peak positions and 1H NMR line widths, as well as dramatic reductions in the MOF 1H T1rho relaxation times, are observed as the PEO content increases, and when the pores have been filled, a further increase in PEO results in the formation of semicrystalline PEO outside the UiO-66 particles.	Hydrogen	53-55	twinkle mtDNA helicase	Homo sapiens	162-165
30973014-3	2019	Systematic changes in MOF 13C NMR peak positions and 1H NMR line widths, as well as dramatic reductions in the MOF 1H T1rho relaxation times, are observed as the PEO content increases, and when the pores have been filled, a further increase in PEO results in the formation of semicrystalline PEO outside the UiO-66 particles.	Hydrogen	115-117	twinkle mtDNA helicase	Homo sapiens	162-165
30735837-7	2019	Moreover, hydrogen reduced the expression of p53, p21 and p16 and the number of blue-green precipitations in the retinas of NaIO3 mice as assessed by SA-beta-gal staining.	Hydrogen	10-18	cyclin dependent kinase inhibitor 2A	Mus musculus	58-61
31106148-8	2019	The docking study indicated that glesatinib interacted with human P-gp through several hydrogen bonds.	Hydrogen	87-95	ATP binding cassette subfamily B member 1	Homo sapiens	66-70
31080186-12	2019	Molecular docking and molecular dynamic simulations studies indicated that FXT interacts with STAT3 through hydrogen bond and hydrophobic interaction.	Hydrogen	108-116	signal transducer and activator of transcription 3	Homo sapiens	94-99
30897325-3	2019	Point mutation of Top1-N722S fails to trap compound 28-induced Top1cc because of its inability to form a hydrogen bond with compound 28.	Hydrogen	105-113	DNA topoisomerase I	Homo sapiens	18-22
31006219-1	2019	Objective: To explore the relationship between apolipoprotein E (ApoE) gene polymorphism and hydrogen proton magnetic resonance spectroscopy ((1)H-MRS) in patients with Alzheimer"s disease (AD) and amnestic mild cognitive impairment(aMCI).	Hydrogen	93-101	apolipoprotein E	Homo sapiens	47-63
31006219-1	2019	Objective: To explore the relationship between apolipoprotein E (ApoE) gene polymorphism and hydrogen proton magnetic resonance spectroscopy ((1)H-MRS) in patients with Alzheimer"s disease (AD) and amnestic mild cognitive impairment(aMCI).	Hydrogen	93-101	apolipoprotein E	Homo sapiens	65-69
30633442-2	2019	L1 and L2 comprise pyridyl triazole chelating units with pendant diaminotriazine units, capable of donor-acceptor-donor (DAD) hydrogen bonding, while L3 and L4 contain ADA hydrogen bonding units proximal to N^N and N^O cleating sites, respectively.	Hydrogen	126-134	L1 cell adhesion molecule	Homo sapiens	0-9
30633442-3	2019	X-ray crystallography shows the L1 and L2 containing RuII complexes to assemble via  R 2 2 8   hydrogen bonding dimers, while [RuII (bpy)2 L4] assembles via extended hydrogen bonding motifs to form one dimensional chains.	Hydrogen	95-103	L1 cell adhesion molecule	Homo sapiens	32-41
30633442-6	2019	The L1 and L2 complexes of IrIII and RuII complexes are emissive in the solid state and it seems likely that hydrogen bonding to complementary species may facilitate tuning of their 3 ILCT emission.	Hydrogen	109-117	L1 cell adhesion molecule	Homo sapiens	4-13
30229448-0	2019	NMR 1H, 13C, 15N backbone and side chain resonance assignment of the N-terminal domain of yeast proteasome lid subunit Rpn5.	Hydrogen	4-6	proteasome regulatory particle lid subunit RPN5	Saccharomyces cerevisiae S288C	119-123
30976000-3	2019	Here, we apply hydrogen-deuterium exchange mass spectrometry to probe the conformational dynamics of human SERT in the absence and presence of known substrates and targeted drugs.	Hydrogen	15-23	solute carrier family 6 member 4	Homo sapiens	107-111
30616164-7	2019	Molecular docking is done on the compounds in comparison with the native ligand (Lanosterol 14alpha-demethylase) and standard drug (fluconazole) to study the hydrogen bond energy interaction.	Hydrogen	158-166	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	81-111
30625420-4	2019	The Cu2O/TiO2 (60 wt%, labeled as CT-60) exhibits the highest enhanced photocatalytic activity in hydrogen production with H2 evolution of 3002.5 mumol g-1.	Hydrogen	98-106	long intergenic non-protein coding RNA 1193	Homo sapiens	34-39
30625420-4	2019	The Cu2O/TiO2 (60 wt%, labeled as CT-60) exhibits the highest enhanced photocatalytic activity in hydrogen production with H2 evolution of 3002.5 mumol g-1.	Hydrogen	123-125	long intergenic non-protein coding RNA 1193	Homo sapiens	34-39
30625420-6	2019	Hydrogen production of the CT-60 is 103 and 8.5 fold higher than the cubic Cu2O and TiO2 nanoparticles, respectively.	Hydrogen	0-8	long intergenic non-protein coding RNA 1193	Homo sapiens	27-32
30694439-0	2019	1H, 15N and 13C backbone assignment of apo TDP-43 RNA recognition motifs.	Hydrogen	0-2	TAR DNA binding protein	Homo sapiens	43-49
31777683-0	2019	Palladium-Catalyzed Chemoselective Activation of sp3 vs sp2 C-H Bonds: Oxidative Coupling To Form Quaternary Centers.	Hydrogen	60-63	Sp2 transcription factor	Homo sapiens	56-59
31040664-10	2019	The binding rate of HS-Fe-PEG-HER2 NPs to targeted cells (SKBR3) was 78.97%+-4.41% in vitro.	Hydrogen	20-23	erb-b2 receptor tyrosine kinase 2	Homo sapiens	30-34
30734528-8	2019	The increased potency of JH-T4 is likely due to the formation of hydrogen bonding between the hydroxy group and SIRT1, SIRT2, and SIRT3.	Hydrogen	65-73	sirtuin 3	Homo sapiens	130-135
30229448-5	2019	We herein report the 1H, 13C and 15N atoms chemical shift assignments of the N-terminal domain (residues 1-136) of Saccharomyces cerevisiae Rpn5, which provide the basis for further studies of the structure, dynamics and interactions of the Rpn5 subunit by NMR technique.	Hydrogen	21-23	proteasome regulatory particle lid subunit RPN5	Saccharomyces cerevisiae S288C	140-144
30229450-0	2019	1H, 13C, and 15N resonance assignments of the C-terminal lobe of the human HECT E3 ubiquitin ligase ITCH.	Hydrogen	0-2	itchy E3 ubiquitin protein ligase	Homo sapiens	100-104
30229450-4	2019	We report here the complete experimentally determined 1H, 13C, and 15N backbone and sidechain resonance assignments for the HECT C-terminal lobe of ITCH (residues 784-903) using heteronuclear, multidimensional NMR spectroscopy.	Hydrogen	54-56	itchy E3 ubiquitin protein ligase	Homo sapiens	148-152
30232732-7	2019	The 2D [15N-1H] HSQC recorded with uniformly 13C/15N labeled gammaS-CTD showed a highly dispersed spectrum indicating the protein to adopt an ordered conformation.	Hydrogen	12-14	CTD	Homo sapiens	68-71
30232732-8	2019	In this paper, we report almost complete sequence-specific 1H, 13C and 15N resonance assignments of gammaS-CTD using a suite of heteronuclear 3D NMR experiments.	Hydrogen	59-61	CTD	Homo sapiens	107-110
30232733-0	2019	Backbone 1H, 13C, and 15N resonance assignments of deubiquitinase A in non-phosphorylated and phosphorylated forms.	Hydrogen	9-11	OTU deubiquitinase 5	Homo sapiens	51-67
30738292-8	2019	The scFv tightly bound to the DSP epitope with the lowest energy level by hydrogen bonds, cation-pi, hydrophobic and ionic interactions demonstrating the specificity of Ag-Ab interactions.	Hydrogen	74-82	immunglobulin heavy chain variable region	Homo sapiens	4-8
30998079-6	2019	Conclusion: The features of the two models are similar, but the hydrogen bond acceptor, which is the main difference between PTH1R agonists and antagonists, suggests it may be essential for the agonist.	Hydrogen	64-72	parathyroid hormone 1 receptor	Homo sapiens	125-130
30660872-0	2019	Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.	Hydrogen	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-76
30660872-0	2019	Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.	Hydrogen	0-8	heme oxygenase 1	Mus musculus	77-81
30660872-2	2019	Our previous studies have found that molecular hydrogen (H2), which has anti-oxidant, anti-inflammatory, and anti-apoptosis effects, had a therapeutic effect on a septic animal model through increasing expression of nuclear factor-erythroid 2-related factor 2 (Nrf2).	Hydrogen	47-55	nuclear factor, erythroid derived 2, like 2	Mus musculus	216-259
30660872-2	2019	Our previous studies have found that molecular hydrogen (H2), which has anti-oxidant, anti-inflammatory, and anti-apoptosis effects, had a therapeutic effect on a septic animal model through increasing expression of nuclear factor-erythroid 2-related factor 2 (Nrf2).	Hydrogen	47-55	nuclear factor, erythroid derived 2, like 2	Mus musculus	261-265
30660872-2	2019	Our previous studies have found that molecular hydrogen (H2), which has anti-oxidant, anti-inflammatory, and anti-apoptosis effects, had a therapeutic effect on a septic animal model through increasing expression of nuclear factor-erythroid 2-related factor 2 (Nrf2).	Hydrogen	57-59	nuclear factor, erythroid derived 2, like 2	Mus musculus	216-259
30660872-2	2019	Our previous studies have found that molecular hydrogen (H2), which has anti-oxidant, anti-inflammatory, and anti-apoptosis effects, had a therapeutic effect on a septic animal model through increasing expression of nuclear factor-erythroid 2-related factor 2 (Nrf2).	Hydrogen	57-59	nuclear factor, erythroid derived 2, like 2	Mus musculus	261-265
30543459-6	2019	We suggest that the beneficial effects of molecular hydrogen may be through the activation of nuclear factor erythroid 2-related factor 2 pathway that promotes innate antioxidants and reduction of apoptosis, as well as inflammation.	Hydrogen	52-60	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-137
30660872-8	2019	RESULTS: The results indicated that 2% H2 gas treatment increased the survival rates, decreased the W/D weight ratio and the lung injury score, alleviated the injuries caused by oxidative stress and inflammation, and induced HO-1 level but reduced HMGB1 level in WT but not Krf2-KO mice.	Hydrogen	39-41	heme oxygenase 1	Mus musculus	225-229
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen	18-20	interleukin 6	Mus musculus	70-83
30660872-9	2019	These data reveal that H2 gas could suppress lung injury in septic mice through regulation of HO-1 and HMGB1 expression and that Nrf2 plays a main role in the protective effects of H2 gas on lung damage caused by sepsis.	Hydrogen	23-25	heme oxygenase 1	Mus musculus	94-98
30660872-9	2019	These data reveal that H2 gas could suppress lung injury in septic mice through regulation of HO-1 and HMGB1 expression and that Nrf2 plays a main role in the protective effects of H2 gas on lung damage caused by sepsis.	Hydrogen	181-183	nuclear factor, erythroid derived 2, like 2	Mus musculus	129-133
29671687-6	2019	Furthermore, two extra hydrogen bonds between AKR1B1 and Mtia2 are found with respect to Mtia1.	Hydrogen	23-31	aldo-keto reductase family 1 member B	Homo sapiens	46-52
29697300-0	2019	Cooperative hydrogen bonds and mobility of the non-aromatic ring as selectivity determinants for human acetylcholinesterase to similar anti-Alzheimer"s galantaminics: a computational study.	Hydrogen	12-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-123
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen	18-20	interleukin 6	Mus musculus	85-89
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen	18-20	signal transducer and activator of transcription 3	Mus musculus	95-145
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen	18-20	signal transducer and activator of transcription 3	Mus musculus	147-152
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen	18-20	signal transducer and activator of transcription 3	Mus musculus	220-225
30789743-8	2019	The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential.	Hydrogen	55-57	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	50-54
30636070-6	2019	Synthetic MciZ analogs, carrying single amino acid substitutions impairing MciZ beta-strand formation or hydrogen bonding to FtsZ, show a gradual reduction in affinity that resembles their impaired activity in bacteria.	Hydrogen	105-113	Z-ring formation inhibitor MciZ	Bacillus subtilis	10-14
30836899-2	2019	The increased bulk of the chromophore within a compact protein and the change in the positioning of atoms capable of hydrogen bonding have made it difficult to optimize their fluorescence properties, which took approximately 15 years between the availability of the first useable CFP, enhanced cyan fluorescent protein (ECFP), and that of a variant with almost perfect fluorescence efficiency, mTurquoise2.	Hydrogen	117-125	complement factor properdin	Homo sapiens	280-283
30343391-0	2019	Hydrogen-Rich Saline Ameliorates Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice Via the Nrf2-ARE Signaling Pathway.	Hydrogen	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
30758069-2	2019	Fast electrophilic attack to the P=O group oxygen atom is favored by exergonic CO2 release to form phosphonium Ph3 PCl+ and chloride Cl- , which may slowly cleave H2 by an unstable HPh3 PCl complex yielding Ph3 PH+ and Cl- ions in solution.	Hydrogen	163-165	polyhomeotic homolog 3	Homo sapiens	181-185
30789743-8	2019	The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential.	Hydrogen	55-57	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	41-45
30789743-8	2019	The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential.	Hydrogen	55-57	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	50-54
30789743-8	2019	The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential.	Hydrogen	55-57	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	50-54
30661613-5	2019	The specific performance of DHAA molecular structure regulation, due to the condensation reaction between dicarbonyl group of DHAA and diamine group of OPD, that is confirmed by ESI-MS and 1H NMR spectra analysis, can remarkably enhance the selectivity of ALP detection, which is conceptually different from the previously reported ALP fluorescent assays.	Hydrogen	189-191	alkaline phosphatase, placental	Homo sapiens	256-259
30789743-8	2019	The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential.	Hydrogen	55-57	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	50-54
30840470-3	2019	Although ATR-FTIR cannot be used for quantitatively determining elemental compositions in polymers at which XPS excels, it is able to be operated under nonvacuum conditions and allows the study of hydrogen-containing moieties.	Hydrogen	197-205	ATR serine/threonine kinase	Homo sapiens	9-12
30661613-5	2019	The specific performance of DHAA molecular structure regulation, due to the condensation reaction between dicarbonyl group of DHAA and diamine group of OPD, that is confirmed by ESI-MS and 1H NMR spectra analysis, can remarkably enhance the selectivity of ALP detection, which is conceptually different from the previously reported ALP fluorescent assays.	Hydrogen	189-191	alkaline phosphatase, placental	Homo sapiens	332-335
30963093-3	2019	Objective: The aim of the current study was to determine the impact of aging on hs-cTnT levels in elderly patients without acute cardiac events but in the presence of comorbidities.	Hydrogen	80-82	troponin T2, cardiac type	Homo sapiens	83-87
30407786-10	2019	Molecular docking identified 11 hits, where they showed the highest ChemPLP score (>90.00), stable conformation, and hydrogen-bond interactions with catalytic residues of HDAC6.	Hydrogen	117-125	histone deacetylase 6	Homo sapiens	171-176
30407786-11	2019	Finally, molecular dynamics simulation identified three molecules as potent HDAC6 inhibitors with stable root-mean-square deviation and the highest number of hydrogen bonds with the catalytic residues of HDAC6.	Hydrogen	158-166	histone deacetylase 6	Homo sapiens	76-81
30407786-11	2019	Finally, molecular dynamics simulation identified three molecules as potent HDAC6 inhibitors with stable root-mean-square deviation and the highest number of hydrogen bonds with the catalytic residues of HDAC6.	Hydrogen	158-166	histone deacetylase 6	Homo sapiens	204-209
30819565-6	2019	Under force, R577 on one protomer switches from interacting with S550 to forming new hydrogen bonds with E553 on the neighboring protomer, resulting in the strengthening of the kindlin2 dimer in complex with integrin beta1.	Hydrogen	85-93	FERM domain containing kindlin 2	Homo sapiens	177-185
30742765-0	2019	Point Mutation of Anabaena Sensory Rhodopsin Enhances Ground-State Hydrogen Out-of-Plane Wag Raman Activity.	Hydrogen	67-75	rhodopsin	Homo sapiens	35-44
30593826-0	2019	Hydrogen bond analysis of the EGFR-ErbB3 heterodimer related to non-small cell lung cancer and drug resistance.	Hydrogen	0-8	epidermal growth factor receptor	Homo sapiens	30-34
30777440-5	2019	By adjusting the content of Ni and Ni2P in the hetrostructure, the optimized hybrid exhibits catalytic performance of H2 generation from the hydrolysis of AB under ambient conditions with a turnover frequency of 68.3 mol (H2) mol-1 (Cat) min-1 and an activation energy ( Ea) of 44.99 kJ mol-1, implying its high potential as an efficient supplement for noble-metal-based catalysts in hydrogen energy applications.	Hydrogen	118-120	catalase	Homo sapiens	233-236
30777440-5	2019	By adjusting the content of Ni and Ni2P in the hetrostructure, the optimized hybrid exhibits catalytic performance of H2 generation from the hydrolysis of AB under ambient conditions with a turnover frequency of 68.3 mol (H2) mol-1 (Cat) min-1 and an activation energy ( Ea) of 44.99 kJ mol-1, implying its high potential as an efficient supplement for noble-metal-based catalysts in hydrogen energy applications.	Hydrogen	118-120	CD59 molecule (CD59 blood group)	Homo sapiens	238-243
30777440-5	2019	By adjusting the content of Ni and Ni2P in the hetrostructure, the optimized hybrid exhibits catalytic performance of H2 generation from the hydrolysis of AB under ambient conditions with a turnover frequency of 68.3 mol (H2) mol-1 (Cat) min-1 and an activation energy ( Ea) of 44.99 kJ mol-1, implying its high potential as an efficient supplement for noble-metal-based catalysts in hydrogen energy applications.	Hydrogen	384-392	catalase	Homo sapiens	233-236
30777440-5	2019	By adjusting the content of Ni and Ni2P in the hetrostructure, the optimized hybrid exhibits catalytic performance of H2 generation from the hydrolysis of AB under ambient conditions with a turnover frequency of 68.3 mol (H2) mol-1 (Cat) min-1 and an activation energy ( Ea) of 44.99 kJ mol-1, implying its high potential as an efficient supplement for noble-metal-based catalysts in hydrogen energy applications.	Hydrogen	384-392	CD59 molecule (CD59 blood group)	Homo sapiens	238-243
30155742-5	2019	Arg143 and Asp108 (Bcl-2), and Glu96 and Tyr195 (Bcl-xL) formed high-affinity hydrogen interactions with the gallate group while non-gallate groups of EGCG formed weak interactions.	Hydrogen	78-86	BCL2 like 1	Homo sapiens	49-55
30703744-6	2019	Bio-reductive hydrogen is able to recover mitochondrial dysfunction, inhibit Abeta generation and aggregation, block synaptic and neuronal apoptosis and promote neuronal energy metabolism by eliminating oxidative stress and activating the anti-oxidative pathway, consequently ameliorating the cognitive impairment in AD mice.	Hydrogen	14-22	histocompatibility 2, class II antigen A, beta 1	Mus musculus	77-82
30609508-6	2019	To get an in-depth understanding of the retention mechanism, linear solvation energy relationship model was established for both C18/GQDs/SiO2 and C18 columns, theoretically calculated data indicated that C18/GQDs/SiO2 column had higher pi-pi stacking and hydrogen-bonding acceptance ability.	Hydrogen	256-264	Bardet-Biedl syndrome 9	Homo sapiens	129-132
30508798-9	2019	Without the use of consumable reducing agents (i.e. H2 gas), sonocatalytic reduction could be a potential candidate of remediation method to treat NO3- polluted water with high N2 selectivity and easy magnetic recovery.	Hydrogen	52-54	NBL1, DAN family BMP antagonist	Homo sapiens	147-150
29471734-7	2019	With a novel application of supervised learning, i.e. the decision tree learning on the hydrogen bonding features in the wild-type and DeltaK9 mutant forms of thrombin, we predict that seven pairs of critical hydrogen bonding interactions are significant for establishing distinct behaviors of wild-type thrombin and its DeltaK9 mutant form.	Hydrogen	88-96	coagulation factor II, thrombin	Homo sapiens	159-167
29471734-7	2019	With a novel application of supervised learning, i.e. the decision tree learning on the hydrogen bonding features in the wild-type and DeltaK9 mutant forms of thrombin, we predict that seven pairs of critical hydrogen bonding interactions are significant for establishing distinct behaviors of wild-type thrombin and its DeltaK9 mutant form.	Hydrogen	88-96	coagulation factor II, thrombin	Homo sapiens	304-312
29471734-7	2019	With a novel application of supervised learning, i.e. the decision tree learning on the hydrogen bonding features in the wild-type and DeltaK9 mutant forms of thrombin, we predict that seven pairs of critical hydrogen bonding interactions are significant for establishing distinct behaviors of wild-type thrombin and its DeltaK9 mutant form.	Hydrogen	209-217	coagulation factor II, thrombin	Homo sapiens	159-167
29471734-7	2019	With a novel application of supervised learning, i.e. the decision tree learning on the hydrogen bonding features in the wild-type and DeltaK9 mutant forms of thrombin, we predict that seven pairs of critical hydrogen bonding interactions are significant for establishing distinct behaviors of wild-type thrombin and its DeltaK9 mutant form.	Hydrogen	209-217	coagulation factor II, thrombin	Homo sapiens	304-312
29557271-3	2019	Rigid Docking analysis of DAH at the ligand binding domain (LBD) of ER alpha showed hydrogen bond interactions with Arg394 and Glu353 at the active site, similar to the positive controls 4-Hydroxy Tamoxifen (4-OHT) and Fulvestrant (FUL).	Hydrogen	84-92	estrogen receptor 1	Homo sapiens	68-76
30535317-7	2019	Results showed that Cd-QDs binds to Gpx3 via Van der Waals" force and hydrogen bonds, resulting in structural changes with increasing contents of alpha-helix.	Hydrogen	70-78	glutathione peroxidase 3	Homo sapiens	36-40
30287344-0	2019	Hydrogen-rich saline protects rat from oxygen glucose deprivation and reperusion-induced apoptosis through VDAC1 via Bcl-2.	Hydrogen	0-8	BCL2, apoptosis regulator	Rattus norvegicus	117-122
30287344-9	2019	RESULTS: In this study, we demonstrated that hydrogen-rich saline (HRS) reduced OGD/RP-mediated neuronal loss by stimulating the expression of Bcl-2, which suppressed the activity of VDAC1.	Hydrogen	45-53	BCL2, apoptosis regulator	Rattus norvegicus	143-148
30294891-9	2019	The high inhibition obtained for compound 10 against COX-2 was explained by hydrogen bond interactions at the enzyme binding site.	Hydrogen	76-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
30892942-1	2019	AIM: Modifying the molecule"s intrinsic hydrogen bond strength (HBS) is a useful approach in optimizing its permeability and P-glycoprotein (P-gp) efflux.	Hydrogen	40-48	ATP binding cassette subfamily B member 1	Homo sapiens	125-139
30892942-1	2019	AIM: Modifying the molecule"s intrinsic hydrogen bond strength (HBS) is a useful approach in optimizing its permeability and P-glycoprotein (P-gp) efflux.	Hydrogen	40-48	ATP binding cassette subfamily B member 1	Homo sapiens	141-145
30609508-6	2019	To get an in-depth understanding of the retention mechanism, linear solvation energy relationship model was established for both C18/GQDs/SiO2 and C18 columns, theoretically calculated data indicated that C18/GQDs/SiO2 column had higher pi-pi stacking and hydrogen-bonding acceptance ability.	Hydrogen	256-264	Bardet-Biedl syndrome 9	Homo sapiens	147-150
30609508-6	2019	To get an in-depth understanding of the retention mechanism, linear solvation energy relationship model was established for both C18/GQDs/SiO2 and C18 columns, theoretically calculated data indicated that C18/GQDs/SiO2 column had higher pi-pi stacking and hydrogen-bonding acceptance ability.	Hydrogen	256-264	Bardet-Biedl syndrome 9	Homo sapiens	147-150
30676741-4	2019	X-ray crystallography and molecular docking analysis of PioOH-bound PPARgamma ligand-binding domain revealed an altered hydrogen bonding network, including the formation of water-mediated bonds, which could underlie its altered biochemical phenotype.	Hydrogen	120-128	peroxisome proliferator activated receptor gamma	Homo sapiens	68-77
30741302-4	2019	An optimum AB hydrolysis rate was obtained when the size of the Ni NPs was 3.2 nm, with an initial turnover frequency of 18.7 mol(hydrogen) mol(catalyst)-1 min-1 and an apparent activation energy of 36 kJ mol-1.	Hydrogen	130-138	CD59 molecule (CD59 blood group)	Homo sapiens	156-161
30729785-4	2019	The docking study reveals that two hydrogen bonds are formed between the side-chain of Lys16 (reactive site 1) of BBI and the glucose-ring hydroxyl groups of STE, which may block BBI from contacting trypsin and thus deactivate the trypsin-inhibitor activity (TIA) of BBI.	Hydrogen	35-43	kunitz trypsin protease inhibitor	Glycine max	231-248
30650965-4	2019	In situ visible and quasi-in situ X-ray absorption spectroscopy reveal that the hydrogen-to-deuterium isotopic substitution induces an equilibrium isotope effect that shifts the oxidation potentials positively by approximately 60 mV for the proton coupled CoII/III and CoIII/IV electron transfer processes.	Hydrogen	80-88	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	269-274
30873235-4	2019	Screening of the library for p53-MDM2 inhibition by fluorescence polarization and 1H,15N HSQC NMR measurements confirm MDM2 binding.	Hydrogen	82-84	tumor protein p53	Homo sapiens	29-32
30523986-1	2019	Absorption of hydrogen by palladium causes PdH to become superconducting below [Formula: see text].	Hydrogen	14-22	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	43-46
30650965-4	2019	In situ visible and quasi-in situ X-ray absorption spectroscopy reveal that the hydrogen-to-deuterium isotopic substitution induces an equilibrium isotope effect that shifts the oxidation potentials positively by approximately 60 mV for the proton coupled CoII/III and CoIII/IV electron transfer processes.	Hydrogen	80-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	256-260
30663758-7	2019	Hydrogen bonding supplemented the SDS-induced stabilization of beta-casein.	Hydrogen	0-8	casein beta	Bos taurus	63-74
30701265-1	2019	Thermolysis of molecular inorganic complex [CoCl2(PPh3)2] has resulted in uniform Co2P nanorods which on grafting on graphene oxide exhibit ultra high hydrogen evolution activity with a cathodic current density of 100 mA cm-2 at an overpotential of 154 mV and excellent stability for at least 70 h.	Hydrogen	151-159	caveolin 1	Homo sapiens	50-54
30791611-3	2019	The aim of this study was to determine whether metabolic reprogramming associated with IDH mutant gliomas leads to additional 1H MRS-detectable differences between IDH1 and IDH2 mutations, and to identify metabolites correlated with 2-HG.	Hydrogen	126-128	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	173-177
30676746-4	2019	The results showed that, compared to a control treatment, applying an electric potential of -0.5 V versus the standard hydrogen electrode (SHE) significantly increased the relative abundance of NO3--reducing microbes (e.g., Alcaligenaceae and Pseudomonadaceae) and the abundances of the nrfA, nirK, nirS, and nosZ genes in soil matrices.	Hydrogen	119-127	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
30522953-0	2019	Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond - Part 2.	Hydrogen	112-120	leucine rich repeat kinase 2	Homo sapiens	32-60
30522953-0	2019	Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond - Part 2.	Hydrogen	112-120	leucine rich repeat kinase 2	Homo sapiens	62-67
30522953-5	2019	A key design element involved the incorporation of an intramolecular hydrogen bond to increase permeability and potency against LRRK2.	Hydrogen	69-77	leucine rich repeat kinase 2	Homo sapiens	128-133
30448715-0	2019	Novel Co(II) and Cu(II) coordination complexes constructed from pyrazole-acetamide: Effect of hydrogen bonding on the self assembly process and antioxidant activity.	Hydrogen	94-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-12
30587451-1	2019	Potent estrogen receptor ligands typically contain a phenolic hydrogen-bond donor.	Hydrogen	62-70	estrogen receptor 1	Homo sapiens	7-24
30362212-6	2019	Although 1h of HBO treatment did not alter the rate of in vitro wound closure or cell proliferation, it increased eNOS expression and decreased ICAM expression and reactive oxygen species production in cells pre-treated with TNF-alpha.	Hydrogen	9-11	tumor necrosis factor	Homo sapiens	225-234
30252533-7	2019	Instead, sodium-hydrogen exchanger type 3 levels in the proximal tubule were dramatically reduced in Epac1-/- and Epac2-/- mice.	Hydrogen	16-24	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	101-106
30252533-10	2019	Deletion of Epac1 and Epac2 decreases sodium-hydrogen exchanger type 3 expression in the proximal tubule, leading to polyuria and osmotic diuresis.-Cherezova, A., Tomilin, V., Buncha, V., Zaika, O., Ortiz, P. A., Mei, F., Cheng, X., Mamenko, M., Pochynyuk, O. Urinary concentrating defect in mice lacking Epac1 or Epac2.	Hydrogen	45-53	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	12-17
29310523-8	2019	Hydrogen bond occupancy of NS7 and NS9 generated from MD trajectories showed good interaction with the flap residues Gln73, Thr72 of BACE-1 and Arg141, Thr138 residues of GSK-3beta.	Hydrogen	0-8	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	27-30
29310523-8	2019	Hydrogen bond occupancy of NS7 and NS9 generated from MD trajectories showed good interaction with the flap residues Gln73, Thr72 of BACE-1 and Arg141, Thr138 residues of GSK-3beta.	Hydrogen	0-8	beta-secretase 1	Homo sapiens	133-139
30891134-0	2019	Enhancing Drug Residence Time by Shielding of Intra-Protein Hydrogen Bonds: A Case Study on CCR2 Antagonists.	Hydrogen	60-68	C-C motif chemokine receptor 2	Homo sapiens	92-96
31223050-7	2019	The hydrogen bonds, hydrophobic interactions, atomic pi-cation interactions and salt bridges of ligands are contributing additional stability to receptor structure, which can lead to blocking the intracellular protein-tyrosine kinase activity, including EGFR associated pathways activation in NSCLC.	Hydrogen	4-12	epidermal growth factor receptor	Homo sapiens	254-258
30585716-1	2019	Two new Co(II) complexes have been synthesized and investigated as catalysts for H2 generation.	Hydrogen	81-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
30723616-8	2019	Results: Our results indicate that two hydrogen bond acceptors, one hydrogen bond donor and one hydrophobic region at certain distances from each other play an important role in achieving high inhibitory potency against hGAT1.	Hydrogen	39-47	solute carrier family 6 member 1	Homo sapiens	220-225
30723616-8	2019	Results: Our results indicate that two hydrogen bond acceptors, one hydrogen bond donor and one hydrophobic region at certain distances from each other play an important role in achieving high inhibitory potency against hGAT1.	Hydrogen	68-76	solute carrier family 6 member 1	Homo sapiens	220-225
30657490-6	2019	Equally important is the fact that the position of both the conduction and valence band edges of the h-BCH sheet matches well with the chemical reaction potential of H2/H+ and O2/H2O, giving a 2D photocatalyst as a potential candidate for overall visible-light-driven water splitting.	Hydrogen	166-168	chimerin 2	Homo sapiens	103-106
29697952-2	2019	In this work, graphdiyne (GD) was first introduced to the visible-light catalytic system for hydrogen production, in which a CdS/GD heterojunction was prepared through a simple in situ growth process by adding Cd(AcO)2 into a dimethyl sulfoxide (DMSO) solution containing GD substrate.	Hydrogen	93-101	aconitase 2	Homo sapiens	213-218
31250600-15	2019	MPO activity in lung tissue was significantly reduced along with decreased productions of TNF-alpha and IL-6, and an increased production of IL-10 in the presence of hydrogen (all P&lt;0.05), demonstrating antioxidant and anti-inflammatory effect of hydrogen in NaHS-induced ALI.	Hydrogen	250-258	tumor necrosis factor	Rattus norvegicus	90-99
30618250-6	2019	Toluene solutions of (tmtaa)CoII have 1H nuclear magnetic resonance (NMR) paramagnetic shifts, a solution-phase magnetic moment mueff (295 K) of 2.1 muB, and toluene glass electron paramagnetic resonance spectra that are most consistent with a low-spin ( S = 1/2) CoII with the unpaired electron located in the d yz orbital.	Hydrogen	38-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-32
30607962-5	2019	The optimized catalysts obtained via calcination at 800  C show a set of remarkable catalytic benefits, including a high hydrogen generation rate of 8.4 mol min-1 mol(Co)-1, a relatively low activation energy of 36.1 kJ mol-1, and a remarkable reusability (at least 10 times).	Hydrogen	121-129	CD59 molecule (CD59 blood group)	Homo sapiens	157-162
30657773-8	2019	The significant increase in concentrations of cortisol, c-reactive protein and myoglobin after the competition, significantly correlated with the significant increase in zonulin concentration (post 1h: r = 0.88, p = 0.007, r = 0,79, p = 0.001, r = 0.78, p = 0.001, and post 12h: r = 0.75, p = 0.01, r = 0.71, p = 0.011, r = 0.83, p = 0.02).	Hydrogen	198-200	haptoglobin	Homo sapiens	170-177
30728903-3	2019	Here, we have identified the fragments of CD160 interacting with HVEM using ELISA tests, hydrogen/deuterium studies, affinity chromatography and mass spectrometry (MS).	Hydrogen	89-97	TNF receptor superfamily member 14	Homo sapiens	65-69
30788005-0	2019	Postconditioning with inhaled hydrogen attenuates skin ischemia/reperfusion injury through the RIP-MLKL-PGAM5/Drp1 necrotic pathway.	Hydrogen	30-38	mixed lineage kinase domain like pseudokinase	Rattus norvegicus	99-103
30728903-4	2019	By combining hydrogen/deuterium exchange and mass spectrometry (HDX-MS) we obtained key information about the tertiary structure of CD160, predicting the 3D structure of the CD160-HVEM complex.	Hydrogen	13-21	TNF receptor superfamily member 14	Homo sapiens	180-184
30511841-6	2019	We arrive at a comprehensive reaction model where the hydrogen-bond rupture with conserved aromatic side chains at the carotenoid beta1-ring in picoseconds occurs at a low yield of &lt;1%, whereby the beta1-ring retains a trans configuration with respect to the conjugated pi-electron chain.	Hydrogen	54-62	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	130-135
31459350-3	2019	In agreement with previous studies, hydrogen production pathways starting from reduction of the resting state of CoII and involving formation of the CoIIIH and CoIIH intermediates are the favorable ones for both bimetallic and monometallic pathways.	Hydrogen	36-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-117
30511841-6	2019	We arrive at a comprehensive reaction model where the hydrogen-bond rupture with conserved aromatic side chains at the carotenoid beta1-ring in picoseconds occurs at a low yield of &lt;1%, whereby the beta1-ring retains a trans configuration with respect to the conjugated pi-electron chain.	Hydrogen	54-62	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	201-206
30713665-5	2018	As demonstrated by enzyme linked immunosorbent assay and 16S rDNA sequence analysis of stool samples, the consumption of hydrogen-rich water for two months significantly reduced serum malondialdehyde, interleukin-1, interleukin-6, tumour necrosis factor-alpha levels; then significantly increased serum superoxide dismutase, total antioxidant capacity levels and haemoglobin levels of whole blood.	Hydrogen	121-129	interleukin 6	Homo sapiens	216-259
30713666-8	2018	Increases of oxidative stress by hydrogen have been previously reported, along with its ability to activate the Nrf2, NF-kappaB pathways, and heat shock responses.	Hydrogen	33-41	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
30621420-5	2019	Moreover, crucial residues previously identified in experimental studies, W3, H133, and S137 of PFN1, were found to form favorable hydrogen bonds with P10, suggesting a zipping process during the binding between PFN1 and P10.	Hydrogen	131-139	profilin 1	Homo sapiens	96-100
30265947-5	2019	As a result, hydrogen bonding network constructed by the ammonio group and NO3- anion is changed.	Hydrogen	13-21	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
30621420-5	2019	Moreover, crucial residues previously identified in experimental studies, W3, H133, and S137 of PFN1, were found to form favorable hydrogen bonds with P10, suggesting a zipping process during the binding between PFN1 and P10.	Hydrogen	131-139	profilin 1	Homo sapiens	212-216
30430709-0	2019	Crystal Structure of Regularly Th -Symmetric [U(NO3 )6 ]2- Salts with Hydrogen Bond Polymers of Diamide Building Blocks.	Hydrogen	70-78	NBL1, DAN family BMP antagonist	Homo sapiens	48-51
30430709-1	2019	Hexanitratouranate(IV), [U(NO3 )6 ]2- , has been crystallized with anhydrous H+ -involving hydrogen bond polymers connected by selected diamide building blocks.	Hydrogen	91-99	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
29911268-5	2019	The best hydrogen production potential was obtained at a COD of 50 g L-1 without nutrient addition.	Hydrogen	9-17	immunoglobulin kappa variable 1-16	Homo sapiens	69-72
29911268-6	2019	This condition produced 528 mL H2 L-1.	Hydrogen	31-33	immunoglobulin kappa variable 1-16	Homo sapiens	34-37
29667549-10	2019	CONCLUSION: Analysis of the structures involving inverse agonists and CB 1 revealed the pivotal role played by residues Phe 170 and Leu 359 in their interactions and the strong intermolecular hydrogen bonds highlighting the importance of the exploration of intermolecular interactions in the development of novel inverse agonists.	Hydrogen	192-200	cannabinoid receptor 1	Homo sapiens	70-74
31875784-7	2019	RESULTS: Abemaciclib showed the greatest tendency to bind CDK-6 via binding 16 residues in the binding site with hydrogen bonds and hydrophobic bonding.	Hydrogen	113-121	cyclin dependent kinase 6	Homo sapiens	58-63
30173652-7	2019	Molecular docking study shows that compound III is located in a pocket, which mainly comprises amino acids 209 to 316 in domain 2 of ATX, and binds with these residues of ATX through van der Waals, conventional hydrogen bonds, and hydrophobic interactions.	Hydrogen	211-219	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	171-174
30261305-6	2019	During mild SI, H2 reduced plasma surges of proinflammatory cytokines (TNF-alpha and IL-6) while caused an increase in plasma IL-10 (anti-inflammatory cytokine) and prevented fever.	Hydrogen	16-18	tumor necrosis factor	Rattus norvegicus	71-80
30261305-6	2019	During mild SI, H2 reduced plasma surges of proinflammatory cytokines (TNF-alpha and IL-6) while caused an increase in plasma IL-10 (anti-inflammatory cytokine) and prevented fever.	Hydrogen	16-18	interleukin 6	Rattus norvegicus	85-89
30261305-8	2019	Moreover, H2 caused a reduction in surges of proinflammatory cytokines (plasma TNF-alpha and IL-1beta) and prostaglandin E2 [(PGE2), in plasma and hypothalamus], and an increase in plasma IL-10.	Hydrogen	10-12	tumor necrosis factor	Rattus norvegicus	79-88
30261305-8	2019	Moreover, H2 caused a reduction in surges of proinflammatory cytokines (plasma TNF-alpha and IL-1beta) and prostaglandin E2 [(PGE2), in plasma and hypothalamus], and an increase in plasma IL-10.	Hydrogen	10-12	interleukin 1 beta	Rattus norvegicus	93-101
31393245-9	2019	Further, characterization by GPC and 1H NMR techniques revealed successful formation of PE-beta-CD-PRTx with a threading efficiency of 16%.	Hydrogen	37-39	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	91-98
31513003-8	2019	RESULTS: Many compounds showed good hydrophobic communications and hydrogen bonding associations to hinder HER2.	Hydrogen	67-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	107-111
30414557-0	2019	Improved regression model to predict an impact of SOD1 mutations on ALS patients survival time based on analysis of hydrogen bond stability.	Hydrogen	116-124	superoxide dismutase 1	Homo sapiens	50-54
30212822-0	2019	The Fructose Hydrogen Breath Test: Nothing Behind the Sweet Fog?	Hydrogen	13-21	zinc finger protein, FOG family member 1	Homo sapiens	60-63
30387805-9	2019	Computational docking suggested that there are three or four possible hydrogen bonds in the active pocket of AKT1 and AKT2 that contribute to the mode of action of resveratrol.	Hydrogen	70-78	AKT serine/threonine kinase 1	Homo sapiens	109-113
30414557-4	2019	Previously, we proposed regression models linking the change in the stability of hydrogen bonds in mutant SOD1 calculated using molecular dynamics and elastic networks with patients survival time.	Hydrogen	81-89	superoxide dismutase 1	Homo sapiens	106-110
30207238-7	2019	Compound 3c exhibited promising antiproliferative activity in HCT-116 interrogating that hydrogen bond-acceptor mediates ligand/PI3Kalpha complex formation on m- position.	Hydrogen	89-97	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	128-137
29189151-4	2019	Acidic hydrogen (-NH) of TZD is a prime pharmacophoric requirement for the activation of PPARgamma.	Hydrogen	7-15	peroxisome proliferator activated receptor gamma	Homo sapiens	89-98
31384895-9	2019	Incubation of cells with 10 mumol/L resveratrol for 1h significantly decreased the expression of MIP-2 protein from (1805.33+-67.54) ng/L to(813.82+-47.21) ng/L, and the difference was significant(P<0.05).	Hydrogen	52-54	chemokine (C-X-C motif) ligand 2	Mus musculus	97-102
30542740-2	2019	As hydrogen gas was recently reported to activate PGC-1alpha, the present study investigated whether it restores exhausted CD8+ T cells to improve prognosis in patients with stage IV colorectal cancer.	Hydrogen	3-11	PPARG coactivator 1 alpha	Homo sapiens	50-60
30542740-7	2019	Notably, hydrogen gas decreased the abundance of exhausted terminal PD-1+ CD8+ T cells, increased that of active terminal PD-1- CD8+ T cells, and improved PFS and OS times, suggesting that the balance between terminal PD1+ and PD1- CD8+ T cells is critical for cancer prognosis.	Hydrogen	9-17	MHC class I antigen 1	Sus scrofa	218-221
30542740-7	2019	Notably, hydrogen gas decreased the abundance of exhausted terminal PD-1+ CD8+ T cells, increased that of active terminal PD-1- CD8+ T cells, and improved PFS and OS times, suggesting that the balance between terminal PD1+ and PD1- CD8+ T cells is critical for cancer prognosis.	Hydrogen	9-17	MHC class I antigen 1	Sus scrofa	227-230
30507194-4	2018	In NO3 and BF4 systems, the effect of water-anion-water structures connected by hydrogen bonds due to the strong interaction of anion-water is large.	Hydrogen	80-88	NBL1, DAN family BMP antagonist	Homo sapiens	3-6
30507194-7	2018	The relaxation time of the anion-water hydrogen bonds in the NO3 system is much longer than those in the other systems.	Hydrogen	39-47	NBL1, DAN family BMP antagonist	Homo sapiens	61-64
30156415-3	2018	First, the DMPC/PSM/cholesterol bilayer features favorable interactions of cholesterol with DMPC and, particularly, PSM lipids, which are supported by hydrogen bonds.	Hydrogen	151-159	folate hydrolase 1	Homo sapiens	16-19
30525164-2	2018	THz absorption spectra have been generated for CO2/H2O and CS2/H2O mixtures embedded in enriched solid para-H2 and numerous observed transitions associated with large-amplitude librational motion of the weakly bound binary CO2H2O and CS2H2O van der Waals cluster molecules have been assigned together with tentative assignments for the ternary CS2(H2O)2 system.	Hydrogen	51-53	chorionic somatomammotropin hormone 2	Homo sapiens	234-237
30525164-4	2018	It is suggested that even a less stable linear conformation of the ternary CS2(H2O)2 system, where one H2O molecule is linked to each S atom of the CS2 subunit, may be formed due to the kinetics associated with the mobility of free H2O molecules in the soft para-H2 medium.	Hydrogen	79-81	chorionic somatomammotropin hormone 2	Homo sapiens	75-78
30525164-4	2018	It is suggested that even a less stable linear conformation of the ternary CS2(H2O)2 system, where one H2O molecule is linked to each S atom of the CS2 subunit, may be formed due to the kinetics associated with the mobility of free H2O molecules in the soft para-H2 medium.	Hydrogen	79-81	chorionic somatomammotropin hormone 2	Homo sapiens	148-151
30156415-3	2018	First, the DMPC/PSM/cholesterol bilayer features favorable interactions of cholesterol with DMPC and, particularly, PSM lipids, which are supported by hydrogen bonds.	Hydrogen	151-159	folate hydrolase 1	Homo sapiens	116-119
30156415-5	2018	Further analysis shows that about 60% of PSM molecules form hydrogen bonds with other PSM or cholesterol molecules and, to a lesser degree, with DMPC lipids.	Hydrogen	60-68	folate hydrolase 1	Homo sapiens	41-44
30156415-5	2018	Further analysis shows that about 60% of PSM molecules form hydrogen bonds with other PSM or cholesterol molecules and, to a lesser degree, with DMPC lipids.	Hydrogen	60-68	folate hydrolase 1	Homo sapiens	86-89
30488933-3	2018	Presence of salt ions increases R2(1H) in the case of lysozyme and diminishes it in the case of BSA.	Hydrogen	35-37	lysozyme	Homo sapiens	54-62
30277633-6	2018	These studies showed that the beta3 -hAA/(S)-ABOC helix displayed a more stable hydrogen-bond network through specific stabilization of the C10 pseudocycles involving the bridgehead NH of the ABOC bicyclic scaffold.	Hydrogen	80-88	homeobox C10	Homo sapiens	140-143
30488933-2	2018	Two well-known proteins, hen egg-white lysozyme (LZM) and bovine serum albumin (BSA), show qualitatively opposite trends in the transverse relaxation rate, R2(1H), along a series of different monovalent salt anions in the solution.	Hydrogen	159-161	lysozyme	Homo sapiens	39-47
30488933-9	2018	The same ordering of salts in their ability to aggregate lysozyme, as seen previously by cloud point measurements, is reproduced here by R2(1H).	Hydrogen	140-142	lysozyme	Homo sapiens	57-65
30488933-2	2018	Two well-known proteins, hen egg-white lysozyme (LZM) and bovine serum albumin (BSA), show qualitatively opposite trends in the transverse relaxation rate, R2(1H), along a series of different monovalent salt anions in the solution.	Hydrogen	159-161	lysozyme	Homo sapiens	49-52
30488933-2	2018	Two well-known proteins, hen egg-white lysozyme (LZM) and bovine serum albumin (BSA), show qualitatively opposite trends in the transverse relaxation rate, R2(1H), along a series of different monovalent salt anions in the solution.	Hydrogen	159-161	albumin	Homo sapiens	65-78
30253836-5	2018	The molecular recognition mechanism was studied by 1H NMR spectra, which indicated that the m-NP and p-NP can be included in the cavity of the pillar [5]arene host.	Hydrogen	51-53	purine nucleoside phosphorylase	Homo sapiens	101-105
30544943-6	2018	Isothermal titration calorimetry and molecular docking revealed that the binding of NQTrp and PAP f39 is spontaneous, and NQTrp predominantly interacts with the polar and charged residues of the peptide by forming hydrogen bonds and hydrophobic contacts with a strong binding energy.	Hydrogen	214-222	PDGFA associated protein 1	Homo sapiens	94-97
30973277-8	2018	The Gene Ontology and KEGG enrichment analyses identified a large number of proteins and biological processes that may responsible for the protective effect of hydrogen, including VEGFA, PDGFB, IGFBP3, EDN1, NADPH oxidase, the coagulation cascade, etc.	Hydrogen	160-168	vascular endothelial growth factor A	Homo sapiens	180-185
29896909-4	2018	Immunoblotting was used to measure levels of H2 S-synthesizing enzymes: cystathionine-beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulphurtransferase (MPST).	Hydrogen	45-47	cystathionine beta-synthase	Homo sapiens	72-99
30479053-5	2018	In the molecular modeling study, compound 4e (docking score = -8.70) showed important hydrogen bond interaction with the amino acids LYS 329, SER 137, GLY 136 and pi-pi interactions with PHE 189 at the active site of GABA-AT.	Hydrogen	86-94	4-aminobutyrate aminotransferase	Homo sapiens	217-224
30251670-6	2018	The most probable active sites of AQP1 for the formation of hydrogen bonds between the inhibitor and the channel were identified by numerical analysis of the bonds.	Hydrogen	60-68	aquaporin 1 (Colton blood group)	Homo sapiens	34-38
30268050-9	2018	Also, compound 4f showed highest potency for ERK2 inhibition with ATP-competitive inhibition mechanism which was confirmed by the formation of three hydrogen bond in the molecular docking studies.	Hydrogen	149-157	mitogen-activated protein kinase 1	Homo sapiens	45-49
30542474-10	2018	H2 inhalation slightly increased the level of interferon-gamma, however the difference was not statistically significant.	Hydrogen	0-2	interferon gamma	Mus musculus	46-62
30973277-8	2018	The Gene Ontology and KEGG enrichment analyses identified a large number of proteins and biological processes that may responsible for the protective effect of hydrogen, including VEGFA, PDGFB, IGFBP3, EDN1, NADPH oxidase, the coagulation cascade, etc.	Hydrogen	160-168	endothelin 1	Homo sapiens	202-206
30973277-9	2018	Conclusions: Molecular hydrogen protects AECIIs from hyperoxic injury by complex mechanisms involving a variety of proteins and biological processes, such as VEGFA, PDGFB, IGFBP3, EDN1, NADPH oxidase and the coagulation cascade.	Hydrogen	23-31	vascular endothelial growth factor A	Homo sapiens	158-163
30973277-9	2018	Conclusions: Molecular hydrogen protects AECIIs from hyperoxic injury by complex mechanisms involving a variety of proteins and biological processes, such as VEGFA, PDGFB, IGFBP3, EDN1, NADPH oxidase and the coagulation cascade.	Hydrogen	23-31	endothelin 1	Homo sapiens	180-184
30380511-8	2018	RESULTS: Therapy with 2% H2 increased PaO2/FiO2 ratios, MMP and ATP levels, RCR, complex I activity and MFN2 expression but decreased histological score and Drp1 levels in the presence of sepsis.	Hydrogen	25-27	dynamin 1-like	Mus musculus	157-161
30243702-9	2018	In the running rats, H2 blunted exercise-induced plasma inflammatory cytokines (TNF-alpha and IL-6) surges.	Hydrogen	21-23	tumor necrosis factor	Rattus norvegicus	80-89
30243702-9	2018	In the running rats, H2 blunted exercise-induced plasma inflammatory cytokines (TNF-alpha and IL-6) surges.	Hydrogen	21-23	interleukin 6	Rattus norvegicus	94-98
30171943-4	2018	1H NMR and 13C NMR spectra showed that CYS-1 contained two alpha-type and four beta-type glycosidic linkages and backbone of CYS-1 has two types of linkages, beta-1   2 and beta-1   4.	Hydrogen	0-2	cystin 1	Mus musculus	39-44
30607149-4	2018	Based on the results, the compounds L1, L2, L4, L5, L6, L7, L10, L15, and L18 may be promising EGFR inhibitors based on docking score and hydrogen bonds.	Hydrogen	138-146	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	60-63
29734851-7	2018	In addition, molecular docking experiments showed that compound C9 binds to FGFR1 to form six hydrogen bonds.	Hydrogen	94-102	fibroblast growth factor receptor 1	Homo sapiens	76-81
30607149-4	2018	Based on the results, the compounds L1, L2, L4, L5, L6, L7, L10, L15, and L18 may be promising EGFR inhibitors based on docking score and hydrogen bonds.	Hydrogen	138-146	epidermal growth factor receptor	Homo sapiens	95-99
30607149-8	2018	The results indicated that the three compounds bound to EGFR active site in a stable manner during the simulation through the formation of new hydrogen bonds with Phe699, Leu694, Gly700, Lys721, Met769, Arg817, and Asp831 with the superiority of compound L15.	Hydrogen	143-151	epidermal growth factor receptor	Homo sapiens	56-60
30842827-6	2019	The nucleation-growth mechanism reveals that the Ln3+ ions and 5-bop produce separated layers, which then grow anisotropically to form nanoribbons by high coordinated valence of Ln3+ ions and biased carboxyl distribution as well as steric hindrance and hydrogen bonds of the boric acid group in 5-bop.	Hydrogen	253-261	BOP	Homo sapiens	65-68
30458729-0	2018	Metabolite differences between glutamate carboxypeptidase II gene knockout mice and their wild-type littermates after traumatic brain injury: a 7-tesla 1H-MRS study.	Hydrogen	152-154	folate hydrolase 1	Mus musculus	31-60
30411639-8	2018	Identified potential inhibitors bind stably at the acetyl-lysine binding pocket of BRD4 and form direct and water-mediated hydrogen bonds with higher occupancy which may contribute to ligand specificity towards BRD4-BD1.	Hydrogen	123-131	bromodomain containing 4	Homo sapiens	83-87
30411639-8	2018	Identified potential inhibitors bind stably at the acetyl-lysine binding pocket of BRD4 and form direct and water-mediated hydrogen bonds with higher occupancy which may contribute to ligand specificity towards BRD4-BD1.	Hydrogen	123-131	bromodomain containing 4	Homo sapiens	211-215
30411639-8	2018	Identified potential inhibitors bind stably at the acetyl-lysine binding pocket of BRD4 and form direct and water-mediated hydrogen bonds with higher occupancy which may contribute to ligand specificity towards BRD4-BD1.	Hydrogen	123-131	defensin beta 1	Homo sapiens	216-219
30348641-7	2018	In silico docking studies indicate that the substrate is further stabilized by a complex hydrogen-bond network, involving amino acids Q109 and K123, identified herein as potential key residues for FAHD1 catalytic activity.	Hydrogen	89-97	fumarylacetoacetate hydrolase domain containing 1	Homo sapiens	197-202
29966848-6	2018	The surface compexation, hydrogen bonds and pi-pi interactions contributed to Pb(II) and 1-naphthol adsorption by means of the hydroxy and carboxyl functional groups on the surface of the beta-CD-GO.	Hydrogen	25-33	submaxillary gland androgen regulated protein 3B	Homo sapiens	78-84
31458229-3	2018	Although Vit C is situated at subsurface beneath SA molecules and interacts via hydrogen bonding between the hydroxyl groups of Vit C and SA, several Vit C molecules may infiltrate within SA two-dimensional matrix at the air-water interface.	Hydrogen	80-88	vitrin	Homo sapiens	9-12
31458229-3	2018	Although Vit C is situated at subsurface beneath SA molecules and interacts via hydrogen bonding between the hydroxyl groups of Vit C and SA, several Vit C molecules may infiltrate within SA two-dimensional matrix at the air-water interface.	Hydrogen	80-88	vitrin	Homo sapiens	128-131
31458229-3	2018	Although Vit C is situated at subsurface beneath SA molecules and interacts via hydrogen bonding between the hydroxyl groups of Vit C and SA, several Vit C molecules may infiltrate within SA two-dimensional matrix at the air-water interface.	Hydrogen	80-88	vitrin	Homo sapiens	128-131
30378425-4	2018	An SN1 mechanism involving activation of the hydroxy group through a hydrogen bond is proposed.	Hydrogen	69-77	solute carrier family 38 member 3	Homo sapiens	3-6
30458729-7	2018	CONCLUSION: Using two non-invasive methods, 1H-MRS and T2 MR imaging, as well as in vitro brain-water content measurements, we demonstrated that the mechanism underlying the neuroprotective effects of GCP II-KO against brain swelling in TBI involves changes in glutamate and N-acetylaspartate levels.	Hydrogen	44-46	folate hydrolase 1	Mus musculus	201-207
30376013-3	2018	According to DFT studies, upon chelating a Zn2+ cation with two imidazole nitrogen atoms, receptor 1 adopts a conformation ideally fitted to recognise HSO4- through a combination of C(sp2)-HO and C(sp3)-HO hydrogen bondings, C+(sp2)-BrO halogen bonding and C(sp2)O tetrel bonding.	Hydrogen	206-214	Sp2 transcription factor	Homo sapiens	182-187
30376013-3	2018	According to DFT studies, upon chelating a Zn2+ cation with two imidazole nitrogen atoms, receptor 1 adopts a conformation ideally fitted to recognise HSO4- through a combination of C(sp2)-HO and C(sp3)-HO hydrogen bondings, C+(sp2)-BrO halogen bonding and C(sp2)O tetrel bonding.	Hydrogen	206-214	Sp2 transcription factor	Homo sapiens	257-262
30303367-4	2018	To overcome the supposedly poor druggability of C-type lectin receptors and to identify starting points for chemical probe development, we screened murine langerin using 1H and 19F NMR against a library of 871 drug-like fragments.	Hydrogen	170-172	CD207 antigen	Mus musculus	155-163
30380790-0	2018	Sloshing Measurements inside a Liquid Hydrogen Tank with External-Heating-Type MgB2 Level Sensors during Marine Transportation by the Training Ship Fukae-Maru.	Hydrogen	38-46	secretoglobin family 2A member 1	Homo sapiens	79-83
30325362-5	2018	Process I is the process of water plasticizing MXD6, which primarily consists of hydrophilic groups forming hydrogen bonds with water molecules and the hydration of hydrophobic groups.	Hydrogen	108-116	MAX network transcriptional repressor	Homo sapiens	47-51
30325362-6	2018	Process II is the strong crystallization of MXD6 induced by water molecules, entailing the generation of the double hydrogen bond and the rearrangement of hydrophilic groups into the crystal lattice.	Hydrogen	116-124	MAX network transcriptional repressor	Homo sapiens	44-48
30282614-0	2018	Ordered opening of LDL receptor binding domain of human apolipoprotein E3 revealed by hydrogen/deuterium exchange mass spectrometry and fluorescence spectroscopy.	Hydrogen	86-94	apolipoprotein E	Homo sapiens	56-73
30282614-6	2018	Hydrogen/deuterium exchange mass spectrometry (HDX-MS) revealed that apoE3 NT domain adopts several disordered and unfolded regions, with H2 exhibiting relatively little protection against exchange-in compared to H1, H3, and H4.	Hydrogen	0-8	apolipoprotein E	Homo sapiens	69-74
30048934-8	2018	IAA binds to CAT with (4.05 +- 1.98) sites via van der Waals and hydrogen bonding interactions, resulting in the loosening of protein skeletons and the change of protein size.	Hydrogen	65-73	catalase	Mus musculus	13-16
29603316-9	2018	We will focus on the mechanisms of the isotopic exchange reactions and on the application of in-ESI, in-APCI, and in-APPI source Hydrogen/Deuterium exchange for the investigation of petroleum, natural organic matter, oligosaccharides, and proteins including protein-protein complexes.	Hydrogen	129-137	amyloid beta precursor protein	Homo sapiens	117-121
30159998-4	2018	The significant changes in geometry induced by a relatively mild temperature increase underline the importance of temperature for the shape and all properties influenced by this shape of hydrogen-bonded clusters of water ice.	Hydrogen	187-195	carboxylesterase 2	Homo sapiens	221-224
30209888-9	2018	The hydrogen gas evolution rate of the NiCo2 S4 /Co9 S8 heterostructure was determined to be 2.29 mumol min-1 .	Hydrogen	4-12	CD59 molecule (CD59 blood group)	Homo sapiens	104-109
30515401-6	2018	A significant time effect was found for sclerostin, which increased from pre-exercise to 5 min after exercise in both trials (100.2 to 131.6 pg/ml in HIIR; 102.3 to 135.8 pg/ml in HIIC, p&lt;0.001) and returned to baseline levels by 1h, with no difference between exercise modes and no exercise mode-by-time interaction.	Hydrogen	233-235	sclerostin	Homo sapiens	40-50
30268500-0	2018	Alternative pathway linked by hydrogen bonds connects heme-Fe of cytochrome c with subunit II-CuA of cytochrome a.	Hydrogen	30-38	cytochrome c, somatic	Homo sapiens	65-77
30367509-10	2018	The expression of Nrf2, CATA, and gamma-GCS in antioxidant system were reduced after H2 O2 processing, which were restored after the application of hydrogen-rich medium.	Hydrogen	148-156	NFE2 like bZIP transcription factor 2	Rattus norvegicus	18-22
30367509-11	2018	Hydrogen water can reduce tendon adhesion after tendon repairing and prohibit excessive inflammatory response, which could be associated with the activation of the Nrf2 pathway.	Hydrogen	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	164-168
30334738-4	2018	Structural analyses of EAAT1 and the consensus designs using hydrogen-deuterium exchange linked to mass spectrometry show that small and highly cooperative unfolding events at the inter-subunit interface rate-limit their thermal denaturation, while the transport domain unfolds at a later stage in the unfolding pathway.	Hydrogen	61-69	solute carrier family 1 member 3	Homo sapiens	23-28
30360629-9	2018	They also report that KGF at the surface of the HEMA/MAA copolymer becomes conformationally unfolded, likely due to hydrogen bonding.	Hydrogen	116-124	fibroblast growth factor 7	Homo sapiens	22-25
30260627-10	2018	The stronger heparin/HS binding site on fibronectin, Hep-II, spans fibronectin type III domains 12-14.	Hydrogen	21-23	fibronectin 1	Homo sapiens	40-51
30260627-10	2018	The stronger heparin/HS binding site on fibronectin, Hep-II, spans fibronectin type III domains 12-14.	Hydrogen	21-23	fibronectin 1	Homo sapiens	67-78
30120952-8	2018	Hydrogen-deuterium exchange studies revealed the footprint of the light-activated rhodopsin on sArr.	Hydrogen	0-8	rhodopsin	Homo sapiens	82-91
30333031-1	2018	BACKGROUND: Sodium/hydrogen exchanger 1 (NHE1), encoded by the SLC9A1 gene (SoLute Carrier family 9A1) in humans, is the main H+ efflux mechanism in maintaining alkaline intracellular pH (pHi) and Warburg effects in glioma.	Hydrogen	19-27	solute carrier family 9 member A1	Homo sapiens	41-45
30229250-5	2018	Molecular docking simulation showed that the two peptides could interact with the ACE site via hydrogen bonds with high binding power.	Hydrogen	95-103	angiotensin I converting enzyme	Homo sapiens	82-85
30333031-1	2018	BACKGROUND: Sodium/hydrogen exchanger 1 (NHE1), encoded by the SLC9A1 gene (SoLute Carrier family 9A1) in humans, is the main H+ efflux mechanism in maintaining alkaline intracellular pH (pHi) and Warburg effects in glioma.	Hydrogen	19-27	solute carrier family 9 member A1	Homo sapiens	63-69
30229250-6	2018	However, the hydrogen bonds were not formed with the key amino acid residues in the active site of ACE.	Hydrogen	13-21	angiotensin I converting enzyme	Homo sapiens	99-102
30226247-2	2018	The conjugate forms homodimer aggregates due to supramolecular interactions between glycoluril moieties, which was confirmed with MALDI-TOF-ms and 1H NMR.	Hydrogen	147-149	superoxide dismutase 1	Homo sapiens	20-29
30131242-5	2018	The primary structure-activity relationship study and docking results showed that the tetrahydroquinoline moiety of compound 4 m played a key role to form hydrogen bonds and pi-pi stacking interaction with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4B.	Hydrogen	155-163	phosphodiesterase 4B	Rattus norvegicus	206-211
30131242-5	2018	The primary structure-activity relationship study and docking results showed that the tetrahydroquinoline moiety of compound 4 m played a key role to form hydrogen bonds and pi-pi stacking interaction with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4B.	Hydrogen	155-163	phosphodiesterase 4B	Rattus norvegicus	363-368
30315173-4	2018	With these unique properties of PdH0.2 nanocrystals, synergetic hydrogenothermal therapy with limited systematic toxicity has been achieved by tumour-targeted delivery and PAI-guided NIR-controlled release of bio-reductive hydrogen as well as generation of heat.	Hydrogen	64-72	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	32-35
30102387-9	2018	Testing permutations of the nucleobase at ribose-methylated position 54 suggested that the extent of silencing and antagonism of the TLR7 response was governed by hydrogen patterns and lipophilic interactions of the nucleobase.	Hydrogen	163-171	toll like receptor 7	Homo sapiens	133-137
30217558-4	2018	Using hydrogen/deuterium exchange mass spectrometry and physical mapping, we define minimal domains necessary for interaction between POLE3-POLE4 and histones H3-H4.	Hydrogen	6-14	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	140-145
30297646-5	2018	The results of the interaction with human serum albumin (HSA) proved that the studied substance quenches the fluorescence of HSA through a static mechanism in which the main interaction forces are Van der Waals and hydrogen bonding.	Hydrogen	215-223	albumin	Homo sapiens	42-55
30850186-2	2018	As a kind of endo-beta-glucuronidase, heparanase is the known only enzyme in mammals which could degrade heparan sulfate(HS) specifically.	Hydrogen	121-123	heparanase	Homo sapiens	38-48
30146101-7	2018	There was a strong association between hs-cTnT categories and risk of AMI.	Hydrogen	39-41	troponin T2, cardiac type	Homo sapiens	42-46
29922878-6	2018	In silico docking simulation also indicates that compound 4c tightly binds to the deep substrate-binding pocket of HDAC6 by coordinating the active zinc ion in a bidentate manner and forming hydrogen bond interactions with Ser531 and His573 amino acid residues.	Hydrogen	191-199	histone deacetylase 6	Homo sapiens	115-120
30850186-4	2018	Heparanase takes effect by cleaving thebeta(1,4)-glycosidic between glucosamine residue and glucuronic acid of HS.	Hydrogen	111-113	heparanase	Homo sapiens	0-10
29868988-5	2018	Here we report nearly complete 1H, 15N, and 13C chemical shifts assignments of the 26 kDa WBSCR27 protein from Mus musculus in complex with the cofactor S-adenosyl-L-methionine (SAM).	Hydrogen	31-33	methyltransferase like 27	Mus musculus	90-97
29713947-7	2018	This work reports the 1H, 15N and 13C resonance assignments of the J-domain of a Hsp40 from Saccharomyces cerevisiae, named Sis1.	Hydrogen	22-24	type I HSP40 co-chaperone YDJ1	Saccharomyces cerevisiae S288C	81-86
29667121-0	2018	Backbone 1H, 13C, and 15N resonance assignments of the ligand binding domain of the human wildtype glucocorticoid receptor and the F602S mutant variant.	Hydrogen	9-11	nuclear receptor subfamily 3 group C member 1	Homo sapiens	99-122
29869749-0	2018	1H, 13C, 15N NMR resonance assignments and secondary structure determination of the extra-cellular domain from the human proapoptotic TRAIL-R2 death receptor 5 (DR5-ECD).	Hydrogen	0-2	TNF superfamily member 10	Homo sapiens	134-139
29744857-10	2018	In conclusion, our findings provided evidence that exogenous H2 S supplied by NaHS exerted biphasic effects on PMECs proliferation, with stimulation at lower doses and suppression at high dose, through the intracellular PI3 K/Akt-mTOR signaling pathway.	Hydrogen	61-63	AKT serine/threonine kinase 1	Homo sapiens	226-229
30382050-3	2018	Recently, hydrogen gas was reported to activate PGC-1a, leading to the enhancement of mitochondrial activity.	Hydrogen	10-18	PPARG coactivator 1 alpha	Homo sapiens	48-54
29842960-4	2018	However, the hydropathic characteristics that hydrophobic methyl groups and hydrophilic amine groups distributed alternatively along the polymer chain made it difficult to penetrate into the hydrophobic core, but subject to binding onto the surface of lysozyme via hydrophobic interaction and hydrogen bond, leading to a more compact conformation and an increased surface hydrophobicity of the enzyme.	Hydrogen	293-301	lysozyme	Homo sapiens	252-260
29744857-0	2018	Exogenous H2 S exerts biphasic effects on porcine mammary epithelial cells proliferation through PI3K/Akt-mTOR signaling pathway.	Hydrogen	10-12	AKT serine/threonine kinase 1	Homo sapiens	102-105
29744857-0	2018	Exogenous H2 S exerts biphasic effects on porcine mammary epithelial cells proliferation through PI3K/Akt-mTOR signaling pathway.	Hydrogen	10-12	mechanistic target of rapamycin kinase	Homo sapiens	106-110
29966870-3	2018	Profiling of donepezil, a potent acetylcholinesterase (hAChE) inhibitor, into BACE-1 inhibition was achieved through introduction of backbone amide linkers to the designed compounds which are capable of hydrogen-bonding with BACE-1 catalytic site.	Hydrogen	203-211	acetylcholinesterase (Cartwright blood group)	Homo sapiens	55-60
29966870-3	2018	Profiling of donepezil, a potent acetylcholinesterase (hAChE) inhibitor, into BACE-1 inhibition was achieved through introduction of backbone amide linkers to the designed compounds which are capable of hydrogen-bonding with BACE-1 catalytic site.	Hydrogen	203-211	beta-secretase 1	Homo sapiens	78-84
30145050-5	2018	Furthermore, we determined the crystal structures of JAK1, JAK2, JAK3, and TYK2 in a complex with peficitinib, and revealed that the 1H-pyrrolo[2,3-b]pyridine-5-carboxamide scaffold of peficitinib forms triple hydrogen bonds with the hinge region.	Hydrogen	210-218	Janus kinase 1	Homo sapiens	53-57
30243887-9	2018	In addition, H2 could increase expression of Bcl-2/Bax ratio and inhibited neurons apoptosis in hippocampus.	Hydrogen	13-15	BCL2 apoptosis regulator	Homo sapiens	45-50
30243887-9	2018	In addition, H2 could increase expression of Bcl-2/Bax ratio and inhibited neurons apoptosis in hippocampus.	Hydrogen	13-15	BCL2 associated X, apoptosis regulator	Homo sapiens	51-54
29777805-1	2018	Safe and efficient carboxymethyl chitosan (CMC)-based heparin-mimicking cross-linked beads (CMC/PAMPS) as adsorbents for the clearance of low-density lipoprotein-cholesterol (LDL-c) in blood purification were prepared through hydrogen bonding interactions followed with in situ cross-linking with 2-acrylamido-2-methyl-1-propanesulfonicacid (AMPS).	Hydrogen	226-234	component of oligomeric golgi complex 2	Homo sapiens	175-180
29744857-10	2018	In conclusion, our findings provided evidence that exogenous H2 S supplied by NaHS exerted biphasic effects on PMECs proliferation, with stimulation at lower doses and suppression at high dose, through the intracellular PI3 K/Akt-mTOR signaling pathway.	Hydrogen	61-63	mechanistic target of rapamycin kinase	Homo sapiens	230-234
30102148-8	2018	Molecular dynamics simulations of DENV NS1 and human GRP78 complex revealed their potential binding sites through hydrogen and hydrophobic bonding.	Hydrogen	114-122	heat shock protein family A (Hsp70) member 5	Homo sapiens	53-58
30104721-4	2018	Here, we present a polyoxoanion, [P2W18O62]6-, that can be reversibly reduced and protonated by 18 electrons/H+ per anion in aqueous solution, and that can act either as a high-performance redox flow battery electrolyte (giving a practical discharged energy density of 225 Wh l-1 with a theoretical energy density of more than 1,000 Wh l-1), or as a mediator in an electrolytic cell for the on-demand generation of hydrogen.	Hydrogen	415-423	immunoglobulin kappa variable 1-16	Homo sapiens	276-279
30104721-4	2018	Here, we present a polyoxoanion, [P2W18O62]6-, that can be reversibly reduced and protonated by 18 electrons/H+ per anion in aqueous solution, and that can act either as a high-performance redox flow battery electrolyte (giving a practical discharged energy density of 225 Wh l-1 with a theoretical energy density of more than 1,000 Wh l-1), or as a mediator in an electrolytic cell for the on-demand generation of hydrogen.	Hydrogen	415-423	immunoglobulin kappa variable 1-16	Homo sapiens	336-339
30293367-20	2018	The mRNA expression levels of TNF-alpha were significantly increased in hydrogen-rich saline group at PIH 6 and 24 (P&lt;0.05 or P&lt;0.01), and the mRNA expression level of IL-6 was significantly increased in hydrogen-rich saline group at PIH 6 (P&lt;0.01).	Hydrogen	72-80	tumor necrosis factor	Rattus norvegicus	30-39
30251920-5	2018	In vitro and in silico cytotoxicity analysis with HEK293 cells revealed the cytotoxic effect of CuO Np as consequences of interaction with histidine and arginine amino acid residues of Sod3 and p53 proteins via hydrogen bond of length 3.09 and 3.32 A leading to oxidative stress ensuing toward apoptosis and cell cycle arrest.	Hydrogen	211-219	superoxide dismutase 3	Homo sapiens	185-189
30184423-2	2018	Although the radical-type character of triplet excited states of diaryl ketones suggests the viability for triggering hydrogen-atom transfer (HAT) and single-electron transfer (SET) processes, among others, their use as multifaceted catalysts in C-C bond-formation via sp3 C-H functionalization of alkane feedstocks still remains rather unexplored.	Hydrogen	118-126	Sp3 transcription factor	Homo sapiens	269-272
30479921-4	2018	This PNAGA-PCBAA hydrogel physically crosslinked by dual amide hydrogen bonds of NAGA exhibits an ultralow solid content (1.6, 98.4 wt% water content), and shear-thinning behavior, body temperature extrudability/self-healability, rapid network recoverability, and very close key parameters (modulus, antifouling/antifibrosis, light transmittance, refractive index, ultrastability) to human vitreous body.	Hydrogen	63-71	alpha-N-acetylgalactosaminidase	Homo sapiens	6-10
30091596-1	2018	A simple method has been developed for the cross dehydrogenative coupling between two different primary alcohols using readily available RuCl2(PPh3)3 as a precatalyst through the borrowing-hydrogen approach.	Hydrogen	51-59	caveolin 1	Homo sapiens	143-147
30293367-20	2018	The mRNA expression levels of TNF-alpha were significantly increased in hydrogen-rich saline group at PIH 6 and 24 (P&lt;0.05 or P&lt;0.01), and the mRNA expression level of IL-6 was significantly increased in hydrogen-rich saline group at PIH 6 (P&lt;0.01).	Hydrogen	72-80	interleukin 6	Rattus norvegicus	174-178
30293367-20	2018	The mRNA expression levels of TNF-alpha were significantly increased in hydrogen-rich saline group at PIH 6 and 24 (P&lt;0.05 or P&lt;0.01), and the mRNA expression level of IL-6 was significantly increased in hydrogen-rich saline group at PIH 6 (P&lt;0.01).	Hydrogen	210-218	tumor necrosis factor	Rattus norvegicus	30-39
30293367-20	2018	The mRNA expression levels of TNF-alpha were significantly increased in hydrogen-rich saline group at PIH 6 and 24 (P&lt;0.05 or P&lt;0.01), and the mRNA expression level of IL-6 was significantly increased in hydrogen-rich saline group at PIH 6 (P&lt;0.01).	Hydrogen	210-218	interleukin 6	Rattus norvegicus	174-178
30293367-21	2018	Compared with those at the corresponding time points in burn group, except for the mRNA expression level of TNF-alpha in hydrogen-rich saline group at PIH 6 showed no significant differences (P&gt;0.05), and the mRNA expression levels of TNF-alpha, IL-1beta, and IL-6 at the other time points in hydrogen-rich saline group were significantly decreased (P&lt;0.05).	Hydrogen	121-129	tumor necrosis factor	Rattus norvegicus	108-117
30064909-4	2018	Although the H2A.Bbd-H2B dimer structure largely resembles that of H2A-H2B, substitution of H2A alphaC helix residues by H2A.Bbd counterparts lead to the transition of a long alphaC-helix to the short 310-helix, likely owing to the rearrangement of the hydrogen-bond network.	Hydrogen	253-261	H2A.B variant histone 2	Homo sapiens	13-20
30232347-0	2018	Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression.	Hydrogen	10-18	heme oxygenase 1	Mus musculus	108-112
30232347-9	2018	Moreover, the expression of Bcl-2, HO-1, and Sirt1 in liver, KCs, and hepatocytes by hydrogen gas were increased, whereas caspase activation, Bax, and acetylation of p53 were suppressed by hydrogen gas.	Hydrogen	85-93	B cell leukemia/lymphoma 2	Mus musculus	28-33
30232347-9	2018	Moreover, the expression of Bcl-2, HO-1, and Sirt1 in liver, KCs, and hepatocytes by hydrogen gas were increased, whereas caspase activation, Bax, and acetylation of p53 were suppressed by hydrogen gas.	Hydrogen	85-93	heme oxygenase 1	Mus musculus	35-39
30232347-9	2018	Moreover, the expression of Bcl-2, HO-1, and Sirt1 in liver, KCs, and hepatocytes by hydrogen gas were increased, whereas caspase activation, Bax, and acetylation of p53 were suppressed by hydrogen gas.	Hydrogen	189-197	B cell leukemia/lymphoma 2	Mus musculus	28-33
30232347-9	2018	Moreover, the expression of Bcl-2, HO-1, and Sirt1 in liver, KCs, and hepatocytes by hydrogen gas were increased, whereas caspase activation, Bax, and acetylation of p53 were suppressed by hydrogen gas.	Hydrogen	189-197	heme oxygenase 1	Mus musculus	35-39
30232347-10	2018	These results demonstrated that H2 treatment ameliorated I/R liver injury in a fatty liver model by reducing hepatocyte apoptosis, inhibiting macrophage activation and inflammatory cytokines, and inducing HO-1 and Sirt1 expression.	Hydrogen	32-34	heme oxygenase 1	Mus musculus	205-209
30160288-6	2018	Arg1173/1137, as the unique residue for CBP/p300, was responsible for the selective binding to CBP30 via cation-pi and hydrogen bond interactions.	Hydrogen	119-127	CREB binding protein	Homo sapiens	40-48
30064909-4	2018	Although the H2A.Bbd-H2B dimer structure largely resembles that of H2A-H2B, substitution of H2A alphaC helix residues by H2A.Bbd counterparts lead to the transition of a long alphaC-helix to the short 310-helix, likely owing to the rearrangement of the hydrogen-bond network.	Hydrogen	253-261	H2A.B variant histone 2	Homo sapiens	121-128
30766971-6	2018	However, epitope mapping studies by hydrogen exchange-mass spectrometry revealed that LE4, PH12, and TB12 shared common contact points on RTA corresponding to RTA alpha-helices D and E and beta-strands d and e located on the back side of RTA relative to the active site.	Hydrogen	36-44	transforming growth factor beta regulated gene 4	Mus musculus	101-105
29990893-6	2018	Metabonomic study of serum biochemical changes by carbon tetrachloride (CCl4)-induced liver fibrosis in rats after CS treatment were performed using 1H-NMR analysis.	Hydrogen	149-151	C-C motif chemokine ligand 4	Rattus norvegicus	72-76
31459186-3	2018	The block elastomer served as a multifunctional crosslinker, constructing a covalent network and interfacial hydrogen bonding that interlinked the elastomer with a soy protein isolate (SPI) matrix.	Hydrogen	109-117	chromogranin A	Homo sapiens	185-188
30213108-5	2018	Molecular docking between stilbenoids with Akt indicated that stilbenoids could form hydrogen bond interactions with the COOH-terminal region of Akt.	Hydrogen	85-93	AKT serine/threonine kinase 1	Rattus norvegicus	43-46
30213108-5	2018	Molecular docking between stilbenoids with Akt indicated that stilbenoids could form hydrogen bond interactions with the COOH-terminal region of Akt.	Hydrogen	85-93	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
29758541-4	2018	Both the physico-chemical and computational docking results indicated that the Co(III)-surfactant complexes are stabilized by hydrogen bonding, hydrophobic and/or van der Waals forces.	Hydrogen	126-134	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	79-86
29921037-5	2018	H2 remarkably decreased ROS accumulation and enhanced antioxidant enzymes activities by up-regulating expression of Nrf2 and its downstream components in wound tissue and/or H2 O2 -treated endothelia.	Hydrogen	0-2	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
29921037-6	2018	Meanwhile, H2 inhibited the overexpression of MCP-1, E-selectin, P-selectin and ICAM-1 in oxidant-induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines (TNF-alpha, IL-1, IL-6 and IL-8) production in the wound.	Hydrogen	11-13	mast cell protease 1	Mus musculus	46-51
29921037-6	2018	Meanwhile, H2 inhibited the overexpression of MCP-1, E-selectin, P-selectin and ICAM-1 in oxidant-induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines (TNF-alpha, IL-1, IL-6 and IL-8) production in the wound.	Hydrogen	11-13	selectin, endothelial cell	Mus musculus	53-63
29921037-6	2018	Meanwhile, H2 inhibited the overexpression of MCP-1, E-selectin, P-selectin and ICAM-1 in oxidant-induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines (TNF-alpha, IL-1, IL-6 and IL-8) production in the wound.	Hydrogen	11-13	selectin, platelet	Mus musculus	65-75
29921037-6	2018	Meanwhile, H2 inhibited the overexpression of MCP-1, E-selectin, P-selectin and ICAM-1 in oxidant-induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines (TNF-alpha, IL-1, IL-6 and IL-8) production in the wound.	Hydrogen	11-13	tumor necrosis factor	Mus musculus	192-201
29921037-6	2018	Meanwhile, H2 inhibited the overexpression of MCP-1, E-selectin, P-selectin and ICAM-1 in oxidant-induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines (TNF-alpha, IL-1, IL-6 and IL-8) production in the wound.	Hydrogen	11-13	interleukin 6	Mus musculus	209-213
29758860-5	2018	We found that at room temperature (20 C), NO3- was reduced at a rate of 0.17 to 0.35mugNg-1h-1, accompanied by the isotope fractionation of N (15epsilon) and O (18epsilon) of 31% to 65% (48.3+-2.0% on average) and 11% to 39% (18.9+-1.7% on average), respectively.	Hydrogen	90-92	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
29808231-8	2018	cUMP forms one hydrogen bond with PDE3B (uracil 3-NH with side chain oxygen of Q988).	Hydrogen	15-23	phosphodiesterase 3B	Rattus norvegicus	34-39
30167902-3	2018	In this in vitro study, the effect of NiTi alloy (with two surface modifications - helium and hydrogen) on gene expression profile of selected interleukins (IL-1beta, IL-6 and IL-8) and matrix metalloproteinases (MMP-1 and MMP-2) in human physiological osteoblasts and human osteoarthritic osteoblasts was examined to respond to a question of the different behavior of bone tissue in the implantation of metallic materials in the presence of cells affected by the osteoarthritic process.	Hydrogen	94-102	interleukin 1 beta	Homo sapiens	157-165
31459098-5	2018	1H-15N heteronuclear single-quantum correlation-NMR titrations showed the potential binding dynamics of S100A11 and S100B interactions.	Hydrogen	0-2	S100 calcium binding protein A11	Homo sapiens	104-111
31459098-5	2018	1H-15N heteronuclear single-quantum correlation-NMR titrations showed the potential binding dynamics of S100A11 and S100B interactions.	Hydrogen	0-2	S100 calcium binding protein B	Homo sapiens	116-121
29480907-5	2018	In this context, the effect of metal containing side-products such as [HNi(PMe3)4]+ on overall H2 oxidation reactivity displayed by Ni-S structures has been investigated quantitatively in addition to external parameters such as solvent and H2 pressure.	Hydrogen	95-97	solute carrier family 5 member 5	Homo sapiens	132-136
30140651-10	2018	IL-6 concentration at 1h after therapy (2274.67+-2120.46 pg/mL) tended to be lower than before therapy (4330.09+-3169.70 pg/mL), but the difference was not statistically significant (P=0.821).	Hydrogen	22-24	interleukin 6	Homo sapiens	0-4
30166578-12	2018	Simulation studies of PFN1 in its wild type (WT) and mutant forms (both G118V and T109M mutants) revealed differential fluctuation patterns and the formation of salt bridges and hydrogen bonds between critical residues that may shed light on differences between WT and mutant PFN1.	Hydrogen	178-186	profilin 1	Homo sapiens	22-26
30059218-2	2018	Alkane carbon sp3 orbitals are represented by edge weighted tetrahedral stellate graphs connected to hydrogen orbitals.	Hydrogen	101-109	Sp3 transcription factor	Homo sapiens	14-17
30133539-5	2018	In particular, the increased (CYP2D6*53) or the decreased (CYP2D6*17) activity seems to be related to a change in dynamics of mainly the BC loop due to a modified hydrogen bonding network around this region.	Hydrogen	163-171	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	30-36
30133539-5	2018	In particular, the increased (CYP2D6*53) or the decreased (CYP2D6*17) activity seems to be related to a change in dynamics of mainly the BC loop due to a modified hydrogen bonding network around this region.	Hydrogen	163-171	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	59-65
29987932-5	2018	This convenient preparation method is also applied for the quadruple-hydrogen-bonded fluorescent supramolecular polymeric microfibers which imply good light propagation property with an optical loss coefficient of 0.02 dB/mum.	Hydrogen	69-77	latexin	Homo sapiens	222-225
30083668-5	2018	Our results show that the presence of the hydrogen atom on the Pt catalyst can efficiently induce the H-diffusion process through the C-C surface, and the Pt-H bond significantly facilitates the H-migration from C-H bonds near to the active Pt catalyst to the adjacent carbon atom with an energy barrier &lt;0.5 eV under ambient conditions.	Hydrogen	42-50	parathyroid hormone	Homo sapiens	155-159
30111129-9	2018	For the simple point-charge water model with flexible molecules (SPC/Fw), which combines the long-ranged intermolecular Coulomb potential with hydrogen-oxygen bond-length vibrations, a flexible hydrogen-oxygen-hydrogen bond angle, and Lennard-Jones oxygen-oxygen potentials, we break up the potential into factors containing between two and six particles.	Hydrogen	143-151	proline rich protein gene cluster	Homo sapiens	65-68
30111129-9	2018	For the simple point-charge water model with flexible molecules (SPC/Fw), which combines the long-ranged intermolecular Coulomb potential with hydrogen-oxygen bond-length vibrations, a flexible hydrogen-oxygen-hydrogen bond angle, and Lennard-Jones oxygen-oxygen potentials, we break up the potential into factors containing between two and six particles.	Hydrogen	194-202	proline rich protein gene cluster	Homo sapiens	65-68
30111129-9	2018	For the simple point-charge water model with flexible molecules (SPC/Fw), which combines the long-ranged intermolecular Coulomb potential with hydrogen-oxygen bond-length vibrations, a flexible hydrogen-oxygen-hydrogen bond angle, and Lennard-Jones oxygen-oxygen potentials, we break up the potential into factors containing between two and six particles.	Hydrogen	194-202	proline rich protein gene cluster	Homo sapiens	65-68
29887396-4	2018	We further demonstrate that T cell-derived tumor necrosis factor alpha (TNF-alpha) can synergize with chemotherapy to intensify oxidative stress and tumor cell death in an NADPH (nicotinamide adenine dinucleotide phosphate hydrogen) oxidase-dependent manner.	Hydrogen	223-231	tumor necrosis factor	Mus musculus	43-70
29887396-4	2018	We further demonstrate that T cell-derived tumor necrosis factor alpha (TNF-alpha) can synergize with chemotherapy to intensify oxidative stress and tumor cell death in an NADPH (nicotinamide adenine dinucleotide phosphate hydrogen) oxidase-dependent manner.	Hydrogen	223-231	tumor necrosis factor	Mus musculus	72-81
30042991-2	2018	The CoII ion possesses an ideal trigonal antiprismatic geometry because of the intermolecular hydrogen-bonds between the metalloligands via counter anions.	Hydrogen	94-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-8
29565041-10	2018	Neuronal COX-2 induction may play region-specific roles in brain lesion progression during HIE development, and inhibition of this response may contribute to the antioxidant/anti-infiammatory neuroprotective effects of H2 treatment.	Hydrogen	219-221	prostaglandin-endoperoxide synthase 2	Sus scrofa	9-14
29969902-3	2018	An association between axial anomer stability and the sum of 1H NMR downfield chemical shifts for protons H-3 and H-5 was observed in D2O with gluco- and galactopyranoses as reference compounds.	Hydrogen	61-63	H3 clustered histone 14	Homo sapiens	106-109
29565041-0	2018	Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs.	Hydrogen	10-18	prostaglandin-endoperoxide synthase 2	Sus scrofa	56-72
29852353-8	2018	Besides, H2 down-regulated the expression of NIBPL, SMC3, SMC5 and SMC6, and also reduced the expression of Cyclin D1, CDK4 and CDK6.	Hydrogen	9-11	cyclin dependent kinase 6	Homo sapiens	128-132
29565041-2	2018	In this study we sought to determine whether COX-2 was induced by asphyxia in newborn pigs, and whether neuronal COX-2 levels were affected by H2 treatment.	Hydrogen	143-145	prostaglandin-endoperoxide synthase 2	Sus scrofa	113-118
29565041-7	2018	H2 treatment essentially prevented the increases in COX-2-immunopositive neurons.	Hydrogen	0-2	prostaglandin-endoperoxide synthase 2	Sus scrofa	52-57
29852353-12	2018	The expression of Ki-67, VEGF and SMC3 were decreased when mice were treated with H2 or cis-platinum, especially for cis-platinum.	Hydrogen	82-84	structural maintenance of chromosomes 3	Mus musculus	34-38
28768463-5	2018	Our results indicated that PcTx1can mainly regulate ASIC1a gating process through hydrogen bonds, which can affect their relative positions of several key domains in ASIC1a, further, a long-range conformational changes path was determined, which is composed of beta1, beta2, beta10, alpha6, alpha7, beta11, and beta12 in ASIC1a.	Hydrogen	82-90	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	261-266
29571113-8	2018	In molecular docking studies compound 5a was bound to the active pocket of the EGFR (PDB 1M17) with five key hydrogen bonds and two pi-pi interaction with binding energies DeltaG = -34.581 Kcal/mol.	Hydrogen	109-117	epidermal growth factor receptor	Homo sapiens	79-83
29956781-0	2018	Hydrogen-rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats.	Hydrogen	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	87-90
29936228-8	2018	Furthermore, RMSD, RMSF, hydrogen binds, Rg and energy analysis during MD simulation certainly indicated the stable binding of selected compounds with COX-2 structure.	Hydrogen	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
29936228-9	2018	Moreover, docking and MD results revealed that hydrophobic contacts and optimum hydrogen bonds were determinant factors in the interactions of in silico hits and COX-2.	Hydrogen	80-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
29907217-0	2018	Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway.	Hydrogen	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	88-92
29907217-17	2018	Moreover, hydrogen-rich water caused Nrf2 to enter the cell nucleus, which resulted in increases in the expression of downstream factors such as HO-1 and NQO1.	Hydrogen	10-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	37-41
29907217-17	2018	Moreover, hydrogen-rich water caused Nrf2 to enter the cell nucleus, which resulted in increases in the expression of downstream factors such as HO-1 and NQO1.	Hydrogen	10-18	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	154-158
29907217-18	2018	CONCLUSIONS: Our results indicate that hydrogen-rich water has neuroprotective effects against TBI by reducing oxidative stress and activating the Nrf2 pathway.	Hydrogen	39-47	NFE2 like bZIP transcription factor 2	Rattus norvegicus	147-151
29802912-5	2018	Further, CA directly activates PTEN through hydrogen bond and hydrophobic interactions.	Hydrogen	44-52	phosphatase and tensin homolog	Mus musculus	31-35
29633446-10	2018	Structural analysis of this variant suggested disruption of a critical hydrogen bond between insulin and the insulin receptor; however, the clinical picture in some individuals also suggested abnormal insulin processing and insulin deficiency.	Hydrogen	71-79	insulin	Homo sapiens	93-100
30004693-3	2018	Hydrogen-deuterium exchange (HDX) mass spectrometry (MS) was used to study the apoA-I conformation in model discoidal lipoproteins similar in size to large plasma HDL.	Hydrogen	0-8	apolipoprotein A1	Homo sapiens	79-85
29762455-13	2018	Furthermore, H2 decreased the activation of NF-kappaB and phosphorylation level of p38.	Hydrogen	13-15	mitogen-activated protein kinase 14	Homo sapiens	83-86
30063205-7	2018	Using high-resolution 1H-NMR spectroscopy, we demonstrated that a long-looped quadruplex in the AZIN1 mRNA co-exists in salt-dependent equilibria with a hairpin structure.	Hydrogen	22-24	antizyme inhibitor 1	Homo sapiens	96-101
30187878-5	2018	RESULTS: 10-gingerol was capable of forming hydrogen bond with such Src residues as TRY-340, MET-341, MET-314, ASP-404, and ILE-336.	Hydrogen	44-52	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	68-71
29896769-0	2018	The Electronic State of Hydrogen in the alpha Phase of the Hydrogen-Storage Material PdH(D)x : Does a Chemical Bond Between Palladium and Hydrogen Exist?	Hydrogen	24-32	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	85-88
29896769-0	2018	The Electronic State of Hydrogen in the alpha Phase of the Hydrogen-Storage Material PdH(D)x : Does a Chemical Bond Between Palladium and Hydrogen Exist?	Hydrogen	59-67	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	85-88
29896769-0	2018	The Electronic State of Hydrogen in the alpha Phase of the Hydrogen-Storage Material PdH(D)x : Does a Chemical Bond Between Palladium and Hydrogen Exist?	Hydrogen	59-67	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	85-88
29965770-5	2018	For its aminopeptidase activity, similar to conventional peptidases, the fourth ligand to the zinc ion is suggested to be an active site water, which is further hydrogen bonded with a downstream glutamic acid, E296.	Hydrogen	161-169	carboxypeptidase Q	Homo sapiens	8-22
29949370-5	2018	There are positive shifts of 290 and 260 mV, respectively, for the CoII/CoI and CoIII-H/CoII-H couples from [Co(DPA-1-MPI)(H2O)](PF6)3 to [Co(DPA-3-MPI)(H2O)](PF6)3, with the former being ~32 times as active as the latter in photocatalytic H2 production.	Hydrogen	123-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
29949370-5	2018	There are positive shifts of 290 and 260 mV, respectively, for the CoII/CoI and CoIII-H/CoII-H couples from [Co(DPA-1-MPI)(H2O)](PF6)3 to [Co(DPA-3-MPI)(H2O)](PF6)3, with the former being ~32 times as active as the latter in photocatalytic H2 production.	Hydrogen	123-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-84
29907328-10	2018	Using amide hydrogen-deuterium exchange mass spectrometry (HDXMS), we identified that BC71 preferentially binds to ATP-bound GRP78 via amino acid residues 244-257 of GRP78.	Hydrogen	12-20	heat shock protein 5	Mus musculus	125-130
29969023-5	2018	Most favorable pathways for hydrogen evolution from Co(III)-hydride species is also investigated.	Hydrogen	28-36	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	55-58
29969023-8	2018	The basicity of cobalt center along with thermodynamic stability of putative CoIII/II-H species is essentially a prime factor in deciding the most favorable pathway for hydrogen evolution.	Hydrogen	169-177	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	77-82
29548476-7	2018	OPPs and ALP mainly form hydrogen bonds, and amino acid residues, Gln375, Asp55, and Thr413 play important roles in the catalysis process.	Hydrogen	25-33	alkaline phosphatase, placental	Homo sapiens	9-12
29575445-6	2018	We observed that Abeta fibrillar oligomers optimize their inherent hydrogen bonds and configurational entropy to stabilize their structure according to the simulation time and their length increase.	Hydrogen	67-75	amyloid beta precursor protein	Homo sapiens	17-22
29916710-2	2018	In this work, we propose a combination of experimental and theoretical tools to shed light on the reaction in model system microperoxidase 11 (MP11-FeIII) and myoglobin (Mb-FeIII), from the estimation of the intrinsic binding constants of the species H2S and hydrosulfide (HS-), and the computational description of the overall binding process.	Hydrogen	273-276	non-compact myelin associated protein	Homo sapiens	143-147
29916710-3	2018	Our results show that H2S and HS- are the main reactive species in Mb-FeIII and MP11-FeIII, respectively, and that the magnitude of their intrinsic binding constants are similar to most of the binding constants reported so far for hemeproteins systems and model compounds.	Hydrogen	30-32	non-compact myelin associated protein	Homo sapiens	80-84
29776834-5	2018	Molecular dynamics simulations assisted our understanding of the role played by an internal hydrogen bond in altering the affinity of this series of molecules for BRD4(1).	Hydrogen	92-100	bromodomain containing 4	Homo sapiens	163-167
29984441-2	2018	Herein, the enhanced chemical stability of CH3 NH3 PbI3 is reported by doping the divalent anion Se2- in the form of PbSe in precursor solutions to enhance the hydrogen-bonding-like interactions between the organic cations and the inorganic framework.	Hydrogen	160-168	fucosyltransferase 2	Homo sapiens	97-100
29973622-0	2018	Direct evidence of a low barrier hydrogen bond in the catalytic triad of a Serine protease.	Hydrogen	33-41	coagulation factor II, thrombin	Homo sapiens	75-90
29915073-6	2018	Despite frequent dissociative events, we observed that hydrogen bonding persists at high pressure, up to at least 20 GPa.	Hydrogen	55-63	glycophorin A (MNS blood group)	Homo sapiens	117-120
29571103-0	2018	TiO2 nanocrystals decorated Z-schemed core-shell CdS-CdO nanorod arrays as high efficiency anodes for photoelectrochemical hydrogen generation.	Hydrogen	123-131	cell adhesion associated, oncogene regulated	Homo sapiens	53-56
29571103-1	2018	TiO2 nanocrystals decorated core-shell CdS-CdO nanorod arrays, TiO2@CdO/CdS NR, were fabricated as high efficiency anodes for photoelctrochemical hydrogen generation.	Hydrogen	146-154	cell adhesion associated, oncogene regulated	Homo sapiens	43-46
29860500-1	2018	Context: We previously demonstrated that insulin infusion altered metabolite concentrations in cerebral tissues assessed with proton magnetic resonance spectroscopy (1H-MRS) in young subjects with high insulin sensitivity, but not in those with low insulin sensitivity.	Hydrogen	166-168	insulin	Homo sapiens	41-48
29571103-1	2018	TiO2 nanocrystals decorated core-shell CdS-CdO nanorod arrays, TiO2@CdO/CdS NR, were fabricated as high efficiency anodes for photoelctrochemical hydrogen generation.	Hydrogen	146-154	cell adhesion associated, oncogene regulated	Homo sapiens	68-71
29757018-5	2018	The first use of hydrogen-deuterium exchange coupled with mass spectroscopy (HDX-MS) to study compound-protein interactions in the PXR-LBD is also addressed.	Hydrogen	17-25	nuclear receptor subfamily 1 group I member 2	Homo sapiens	131-134
29512220-6	2018	Hydrogen bonds and van der Waals force were the major power that fixed lamivudine on Sudlow"s site I in subdomain IIA of HSA molecule.	Hydrogen	0-8	albumin	Homo sapiens	121-124
29891674-8	2018	Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts.	Hydrogen	122-130	caspase 1	Homo sapiens	21-30
29546905-3	2018	Due to the weak intermolecular interaction, 1H NMR measurement at low temperature (-40 to 10  C) was required.	Hydrogen	44-46	Rho GTPase activating protein 9	Homo sapiens	90-95
29862809-6	2018	Notably, we find that an electrostatic interaction between Co(II) and one hydrogen atom from a thiophenolate group in the xz plane increases the energy of the d x2- y2 orbital, leading to the nearly equal population with d xy and strong magnetic anisotropy.	Hydrogen	74-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
30310673-9	2018	Computational and experimental analysis elucidated the mechanism of toxicity as a consequence of influential functionality of Sod1 and p53 proteins due to interaction and internalization of the nanohybrids with amino acid residues via hydrogen bonds and hydrophobic interactions.	Hydrogen	235-243	superoxide dismutase 1, soluble	Mus musculus	126-130
29902210-7	2018	The binary complex models of S100A9-S100A12 were developed using data obtained from 1H-15N HSQC NMR titrations and the HADDOCK program.	Hydrogen	84-86	S100 calcium binding protein A12	Homo sapiens	36-43
29892907-2	2018	In order to understand how a single 5mC regulates protein-DNA interactions, we have compared the structures and dynamics of CEBP/betaprotein-DNA complexes before and after methylation, and the results indicate that even a single 5mC can regulate protein-DNA recognition by steric-hindrance effect of methyl group and changing the hydrogen bond interactions.	Hydrogen	330-338	CCAAT enhancer binding protein alpha	Homo sapiens	124-128
29980922-5	2018	The SMD simulations show that RS194B retains in more stable gauche conformation inside the active gorge of AChE during different time intervals that experiences more hydrogen bonding, hydrophobic interactions with the catalytic anionic site (CAS) residues and weaker interactions with the peripheral anionic site (PAS) residues compared to RS41A and RS69N.	Hydrogen	166-174	acetylcholinesterase (Cartwright blood group)	Homo sapiens	107-111
29743242-5	2018	Molecular dynamics simulations revealed that the CDK9/CycT1 interface is stabilized by intramolecular hydrogen bonding of pThr-186 by an arginine triad and Glu-96 of CycT1.	Hydrogen	102-110	cyclin dependent kinase 9	Homo sapiens	49-53
29743242-5	2018	Molecular dynamics simulations revealed that the CDK9/CycT1 interface is stabilized by intramolecular hydrogen bonding of pThr-186 by an arginine triad and Glu-96 of CycT1.	Hydrogen	102-110	cyclin T1	Homo sapiens	54-59
29743242-5	2018	Molecular dynamics simulations revealed that the CDK9/CycT1 interface is stabilized by intramolecular hydrogen bonding of pThr-186 by an arginine triad and Glu-96 of CycT1.	Hydrogen	102-110	cyclin T1	Homo sapiens	166-171
29988358-8	2018	Treatment of compound-1H could arrest cell cycle in S phase through up-regulating P21 and P53, and down-regulating cyclin A and E in a dose-dependent manner.	Hydrogen	22-24	tumor protein p53	Homo sapiens	90-93
29988358-8	2018	Treatment of compound-1H could arrest cell cycle in S phase through up-regulating P21 and P53, and down-regulating cyclin A and E in a dose-dependent manner.	Hydrogen	22-24	cyclin A2	Homo sapiens	115-123
29988358-9	2018	Compound-1H also induced mitochondrial-dependent apoptosis by increasing Bax, cleaved caspase-3, cleaved caspase-9 and poly ADP-ribose polymerase expression, and decreasing Bcl-2 expression.	Hydrogen	9-11	BCL2 associated X, apoptosis regulator	Homo sapiens	73-76
29988358-9	2018	Compound-1H also induced mitochondrial-dependent apoptosis by increasing Bax, cleaved caspase-3, cleaved caspase-9 and poly ADP-ribose polymerase expression, and decreasing Bcl-2 expression.	Hydrogen	9-11	poly(ADP-ribose) polymerase 1	Homo sapiens	119-145
29988358-9	2018	Compound-1H also induced mitochondrial-dependent apoptosis by increasing Bax, cleaved caspase-3, cleaved caspase-9 and poly ADP-ribose polymerase expression, and decreasing Bcl-2 expression.	Hydrogen	9-11	BCL2 apoptosis regulator	Homo sapiens	173-178
29988358-11	2018	Conclusions: Our results suggest that it is the first time to report the compound-1H with benzimidazoleisoquinolinone core playing antitumor activity in human glioblastoma cells by inhibiting Raf/MEK/ERK and PI3K/AKT signaling pathways, and it could be as a lead compound for the further development of targeted glioblastoma cancer therapy.	Hydrogen	82-84	mitogen-activated protein kinase kinase 7	Homo sapiens	196-199
29988358-11	2018	Conclusions: Our results suggest that it is the first time to report the compound-1H with benzimidazoleisoquinolinone core playing antitumor activity in human glioblastoma cells by inhibiting Raf/MEK/ERK and PI3K/AKT signaling pathways, and it could be as a lead compound for the further development of targeted glioblastoma cancer therapy.	Hydrogen	82-84	mitogen-activated protein kinase 1	Homo sapiens	200-203
29988358-11	2018	Conclusions: Our results suggest that it is the first time to report the compound-1H with benzimidazoleisoquinolinone core playing antitumor activity in human glioblastoma cells by inhibiting Raf/MEK/ERK and PI3K/AKT signaling pathways, and it could be as a lead compound for the further development of targeted glioblastoma cancer therapy.	Hydrogen	82-84	AKT serine/threonine kinase 1	Homo sapiens	213-216
29738674-4	2018	The crystal structure of the menin-28 complex revealed a hydrogen bond with Glu366 and hydrophobic interactions, which contributed to strong inhibitory activity of 28.	Hydrogen	57-65	menin 1	Homo sapiens	29-34
29532858-0	2018	Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells.	Hydrogen	0-8	AKT serine/threonine kinase 1	Homo sapiens	47-50
29910719-4	2018	The molecular docking results show that AZD3293 binds within the active region of BACE1 by forming hydrogen bonds against Asp32 and Lys107 with distances 2.95 and 2.68 A, respectively.	Hydrogen	99-107	beta-secretase 1	Homo sapiens	82-87
29858715-4	2018	Here, we present the analysis of the N-glycosylation of PIP isolated from different sources by LC-MS(/MS) and 1H-NMR.	Hydrogen	110-112	prolactin induced protein	Homo sapiens	56-59
29532858-8	2018	All of the results indicated that hydrogen decreased the levels of reactive oxygen species, 8-iso-prostaglandin F2alpha and malondialdehyde, and promoted the UVB exposure-induced expression of PI3K, Akt, Nrf2 and heme oxygenase-1 in HaCaT cells.	Hydrogen	34-42	AKT serine/threonine kinase 1	Homo sapiens	199-202
29532858-8	2018	All of the results indicated that hydrogen decreased the levels of reactive oxygen species, 8-iso-prostaglandin F2alpha and malondialdehyde, and promoted the UVB exposure-induced expression of PI3K, Akt, Nrf2 and heme oxygenase-1 in HaCaT cells.	Hydrogen	34-42	NFE2 like bZIP transcription factor 2	Homo sapiens	204-208
29532858-10	2018	Therefore, hydrogen effectively protects cells from UVB radiation-induced oxidative stress by inhibiting Nrf2/HO-1 activation through the PI3K/Akt signaling pathway.	Hydrogen	11-19	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
29532858-10	2018	Therefore, hydrogen effectively protects cells from UVB radiation-induced oxidative stress by inhibiting Nrf2/HO-1 activation through the PI3K/Akt signaling pathway.	Hydrogen	11-19	AKT serine/threonine kinase 1	Homo sapiens	143-146
29505789-5	2018	Notably, the consequence of TLR3 activation on neuronal function was reproduced in iPSC-derived cortical neurons, with poly I:C (25 mug/ml, 1h) significantly inhibiting sAP firing.	Hydrogen	140-142	SH2 domain containing 1A	Homo sapiens	169-172
28592206-6	2018	Conformational changes coupled with quantitative analysis of center of mass (COM) distance, radius of gyration (Rg), and number of intermolecular hydrogen bonds in each IL6 protein-aptamer complex was used to determine their binding performance strength and obtain molecular configurations with strong binding.	Hydrogen	146-154	interleukin 6	Homo sapiens	169-172
29363191-6	2018	Furthermore, thermodynamic analysis indicated that the hydrogen bond or Van der Waals force was the main interaction force in the process of EGFR binding to all 5 ligands.	Hydrogen	55-63	epidermal growth factor receptor	Homo sapiens	141-145
30069319-13	2018	Results: H2 ameliorated CS-induced lung function decline, emphysema, inflammatory cell infiltration, small-airway remodelling, goblet-cell hyperplasia in tracheal epithelium and activated ERK1/2 and NF-kappaB in mouse lung.	Hydrogen	9-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	199-208
30069319-16	2018	Conclusions: These findings demonstrated that H2 inhalation could inhibit CS-induced COPD development in mice, which is associated with reduced ERK1/2 and NF-kappaB-dependent inflammatory responses.	Hydrogen	46-48	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	155-164
29511334-8	2018	1H MRS was conducted in the dorsal anterior cingulate cortex (dACC), an integrative neocortical hub, during the peak period of drug responses (140-150 m post ingestion).	Hydrogen	0-2	Acetyl-CoA carboxylase	Drosophila melanogaster	62-66
29689155-5	2018	The NO3-  (R1)(R2)NH2+ ion pairs preferentially remain at the interface over the picosecond time scale, where they are stabilized via hydrogen bonding with surface water molecules.	Hydrogen	134-142	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
29645318-0	2018	Investigating the dynamics and polyanion binding sites of fibroblast growth factor-1 using hydrogen-deuterium exchange mass spectrometry.	Hydrogen	91-99	fibroblast growth factor 1	Homo sapiens	58-84
29745664-1	2018	A two-layer ONIOM[QCISD(T)/CBS:DFT] method was proposed for the high-level single-point energy calculations of large biodiesel molecules and was validated for the hydrogen abstraction reactions of unsaturated methyl esters that are important components of real biodiesel.	Hydrogen	163-171	cystathionine beta-synthase	Homo sapiens	27-30
29587225-0	2018	Hydrogen deuterium exchange reveals changes to protein dynamics of recombinant human erythropoietin upon N- and O- desialylation.	Hydrogen	0-8	erythropoietin	Homo sapiens	85-99
29587225-4	2018	Here we investigate the changes to EPO dynamics following enzymatic trimming of terminal sialic acid by amide hydrogen deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	110-118	erythropoietin	Homo sapiens	35-38
29847807-0	2018	Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange.	Hydrogen	77-85	capping protein regulator and myosin 1 linker 1	Homo sapiens	23-29
29847807-6	2018	We used hydrogen-deuterium exchange with mass spectrometry (HDX-MS) to probe changes in structural dynamics induced by V-1 and CARMIL binding to CP.	Hydrogen	8-16	capping protein regulator and myosin 1 linker 1	Homo sapiens	127-133
29649741-3	2018	Both of them can be well docked into the acetyl-lysine (KAc) binding pocket of BRD4, forming key interactions including the critical hydrogen bonds with Asn140 directly and Tyr97 indirectly via a H2O molecule.	Hydrogen	133-141	bromodomain containing 4	Homo sapiens	79-83
29633454-3	2018	Environmentally benign twofold C-H/C-H functionalizations were accomplished with weakly coordinating benzoic acids and benzamides, employing electricity as the terminal oxidant and generating H2 as the sole byproduct.	Hydrogen	192-194	churchill domain containing 1	Homo sapiens	31-38
29537140-5	2018	The sum transformation is ArH+H2 O ArOH+H2 .	Hydrogen	30-32	low density lipoprotein receptor adaptor protein 1	Homo sapiens	26-29
29634247-2	2018	The W215A thrombin mutant was reported to have decreased activity toward fibrinogen without significant loss of activity toward protein C. To understand how mutation of Trp215 may alter thrombin specificity, hydrogen-deuterium exchange experiments (HDXMS), accelerated molecular dynamics (AMD) simulations, and activity assays were carried out to compare the dynamics of Trp215 mutants with those of wild type (WT) thrombin.	Hydrogen	208-216	coagulation factor II, thrombin	Homo sapiens	10-18
29537140-5	2018	The sum transformation is ArH+H2 O ArOH+H2 .	Hydrogen	40-42	low density lipoprotein receptor adaptor protein 1	Homo sapiens	26-29
29414361-3	2018	Multiple regression model analysis indicated that lysozyme levels exhibited a consistent negative association with methane (CH4: beta = -76.3, 95% CI -105 to -47.7) and sulfuretted hydrogen (H2S: beta = -11.7, 95% CI -20.2 to -3.19).	Hydrogen	181-189	lysozyme	Homo sapiens	50-58
29392883-7	2018	Hydrogen-bond trends between ERalpha and the 4,4"-bisphenols were limited to residue Glu353, which interacted with the -OH of one phenol and the -OH of the A ring of 17beta-estradiol; hydrogen-bonding varied at the -OH of ring D of 17beta-estradiol and the second phenol -OH group.	Hydrogen	0-8	estrogen receptor 1	Homo sapiens	29-36
29392883-7	2018	Hydrogen-bond trends between ERalpha and the 4,4"-bisphenols were limited to residue Glu353, which interacted with the -OH of one phenol and the -OH of the A ring of 17beta-estradiol; hydrogen-bonding varied at the -OH of ring D of 17beta-estradiol and the second phenol -OH group.	Hydrogen	184-192	estrogen receptor 1	Homo sapiens	29-36
29392883-8	2018	While both estrogen and androgen bioassays correlated to in silico results, conservation of hydrogen-bonding residues in the androgen receptor provides a convincing picture of direct antagonist binding by 4,4"-bisphenols.	Hydrogen	92-100	androgen receptor	Homo sapiens	125-142
28504004-4	2018	The primary binding pattern is determined by hydrophobic interaction and hydrogen binding occurring in so-called site I of HSA.	Hydrogen	73-81	albumin	Homo sapiens	123-126
29500740-0	2018	Determination of Backbone Amide Hydrogen Exchange Rates of Cytochrome c Using Partially Scrambled Electron Transfer Dissociation Data.	Hydrogen	32-40	cytochrome c, somatic	Homo sapiens	59-71
30108979-2	2018	In this study, the influence of replacing a hydrogen atom with fluorine on the pKa and Pgp-mediated efflux is elucidated for a series of PDE9 inhibitors.	Hydrogen	44-52	ATP binding cassette subfamily B member 1	Homo sapiens	87-90
29500740-8	2018	The method determined 31 backbone amide hydrogen exchange rates of cytochrome c in the non-scrambled regions.	Hydrogen	40-48	cytochrome c, somatic	Homo sapiens	67-79
29442889-7	2018	The possibility of using TNT as a biosensor platform was confirmed in hydrogen detection.	Hydrogen	70-78	chromosome 16 open reading frame 82	Homo sapiens	25-28
29383749-8	2018	Subtle differences in the intra BB loop hydrogen bonding network between TLR3 and TLR2 are also observed.	Hydrogen	40-48	toll like receptor 2	Homo sapiens	82-86
29220697-7	2018	SOD oxidation preferred dissolved H2S over hydrosulfide anion (HS-), whereas HS- inhibited polysulfide production.	Hydrogen	63-65	superoxide dismutase 1	Homo sapiens	0-3
29511086-4	2018	In this work we measured the local dynamics of the IF state of P-gp in lipid nanodiscs and in detergent solution by hydrogen-deuterium (H/D) exchange MS. We observed "EX1 exchange kinetics," or bimodal kinetics, for several peptides distributed in both NBDs, particularly for P-gp in the lipid nanodiscs.	Hydrogen	116-124	ATP binding cassette subfamily B member 1	Homo sapiens	63-67
29429898-4	2018	Proton transfer in the hydrogen bond network triggers flavin reduction in p-hydroxybenzoate hydroxylase, but the mechanism triggering flavin reduction in KMO is different.	Hydrogen	23-31	kynurenine 3-monooxygenase	Saccharomyces cerevisiae S288C	154-157
29587221-4	2018	Structure-activity relationship studies showed that a hydrogen-bonding interaction in the head section is important factors for the enhancement of ERalpha-binding affinity.	Hydrogen	54-62	estrogen receptor 1	Homo sapiens	147-154
31458669-1	2018	The intensity ratio between the first (373 nm) and the third (383 nm) vibronic peaks [I 1/I 3, as the pyrene (Py) scale] of fluorescent Py was used to monitor the critical concentration, drug-loading, and -releasing behaviors of a Py-terminated, amphiphilic polypeptide PPM and its hydrogen-bonded interpolymer complex (HIPC) with poly(acrylic acid) (PAA).	Hydrogen	282-290	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	86-93
29690613-3	2018	The results showed that when the reaction temperature was 10-70 &amp;deg;C, the GO reacted with PPD through non-covalent ionic bonds (-COO&amp;minus;H3+N-R) and hydrogen bonds (C-OH&amp;hellip;H2N-X).	Hydrogen	161-169	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	96-99
29579393-4	2018	The comparison clearly illustrates that increasing the s-character of the nitrogen lone pair decreases the hydrogen-bond acceptor strength (sp3 &gt; sp2 &gt; sp).	Hydrogen	107-115	Sp3 transcription factor	Homo sapiens	140-143
29579393-4	2018	The comparison clearly illustrates that increasing the s-character of the nitrogen lone pair decreases the hydrogen-bond acceptor strength (sp3 &gt; sp2 &gt; sp).	Hydrogen	107-115	Sp2 transcription factor	Homo sapiens	149-152
29527891-6	2018	The observed reaction rates were independent from the partial pressure of hydrogen and hydrogen consumption only stopped in supplemental microcosm experiments where salinity was increased above 35 g L-1.	Hydrogen	87-95	immunoglobulin kappa variable 1-16	Homo sapiens	199-202
29670058-3	2018	The chemical structure of C-PIM was characterised by 1H NMR, 13C NMR, FTIR, elemental analysis, UV-Vis, TGA and TGA-MS.	Hydrogen	53-55	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	28-31
29663617-4	2018	These secondary interactions are stronger in the tetrel-bonded complexes with the sp2 bases, particularly in the isomers of OCS:imidazole and OCS : N2 H2 , where they may be described as distorted N-H   O or N-H   S hydrogen bonds.	Hydrogen	216-224	Sp2 transcription factor	Homo sapiens	82-85
29521512-4	2018	In this study, we identified adverse metabolic changes in the lactation network (mammary, liver, and serum) associated with AHR activation using 1H nuclear magnetic resonance (NMR)-based metabolomics.	Hydrogen	145-147	aryl-hydrocarbon receptor	Mus musculus	124-127
29382582-5	2018	Molecular electrostatic potential maps and molecular dynamics (MD) simulation of the wild type and mutated thrombin showed the key role played by the Na+ ion for its coagulant mechanism by analysing the charge distribution and nature of the hydrogen bonding at the mutated region of interest.	Hydrogen	241-249	coagulation factor II, thrombin	Homo sapiens	107-115
29408130-4	2018	The as-prepared Pt@h-mNSiO2 catalyst exhibited superior activity for hydrogen generation from the hydrolysis of ammonia borane, with a turnover frequency of 371.7 molH2 mol-1Pt min-1 at ambient temperature, probably owing to the abundant mesopores and high surface area, leading to a considerable increase in the accessible active sites.	Hydrogen	69-77	CD59 molecule (CD59 blood group)	Homo sapiens	177-182
29643478-5	2018	Using a novel method of mucus purification, we demonstrate the mechanism of assembly of Muc2 oligomers into viscoelastic microscale domains formed via hydrogen bonding and Ca2+-mediated links, which require the joint presence of Ca2+ ions and non-mucin proteins.	Hydrogen	151-159	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	88-92
28905237-0	2018	1H, 13C and 15N assignments of the C-terminal intrinsically disordered cytosolic fragment of the receptor tyrosine kinase ErbB2.	Hydrogen	0-2	erb-b2 receptor tyrosine kinase 2	Homo sapiens	122-127
29642378-14	2018	This study has demonstrated that 1H-NMR metabolomics coupled with multivariate analysis is capable of distinguishing both rumen-fluid and milk derived from cows on different feeding systems, specifically between indoor TMR and pasture-based diets used in this study.	Hydrogen	33-35	Weaning weight-maternal milk	Bos taurus	138-142
29079376-2	2018	The original model (MACS) included two biomarkers: high sensitivity cardiac troponin T (hs-cTnT) and heart-type fatty acid binding protein (h-FABP).	Hydrogen	88-90	troponin T2, cardiac type	Homo sapiens	91-95
29166542-9	2018	The result of molecular docking further confirmed that artocarpin interacted with CYP2D6, CYP2C8 and CYP3A4 through hydrogen bonds.	Hydrogen	116-124	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	101-107
29063999-0	2018	Backbone 1H, 13C and 15N resonance assignments of the OB domain of the single stranded DNA-binding protein hSSB2 (NABP1/OBFC2A) and chemical shift mapping of the DNA-binding interface.	Hydrogen	9-11	nucleic acid binding protein 1	Homo sapiens	107-112
29067546-0	2018	1H, 13C and 15N chemical shift assignment of lissencephaly-1 homology (LisH) domain homodimer of human two-hybrid-associated protein 1 with RanBPM (Twa1).	Hydrogen	0-2	RAN binding protein 9	Homo sapiens	140-146
29044685-11	2018	The CPA-induced activation of NF-kappaB signals appeared to cause CSE overexpression in the bladder, contributing to bladder pain and in part swelling, possibly through H2 S/Cav 3.2 signaling.	Hydrogen	169-171	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	30-39
29477888-6	2018	Molecular docking attributed its good activity to its key binding interactions in PDE-4B active site with additional hydrogen bonding with amino acids lining the metal pocket.	Hydrogen	117-125	phosphodiesterase 4B	Homo sapiens	82-88
28589454-4	2018	The chemical conjugation of PEG onto the CNP surface was confirmed by a series of physico-chemical characterizations (1H-NMR, FTIR, and surface zeta potential).	Hydrogen	118-120	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	41-44
29274368-13	2018	H2.35 liver cells with shRNA knockdown of ANLN formed tumors more slowly in FRG mice than control H2.35 cells.	Hydrogen	0-2	anillin, actin binding protein	Mus musculus	42-46
29444415-8	2018	It interacted with important amino acid residues in BACE1, such as ASN37, GLN73, and TRP76, through hydrogen bonding.	Hydrogen	100-108	beta-secretase 1	Homo sapiens	52-57
29339412-9	2018	Hydrogen-deuterium exchange mass spectrometry was used to identify a stable binding site for AGR2 on EpCAM, adjacent to the TLIYY motif and surrounding EpCAM"s detergent binding site.	Hydrogen	0-8	epithelial cell adhesion molecule	Homo sapiens	101-106
29339412-9	2018	Hydrogen-deuterium exchange mass spectrometry was used to identify a stable binding site for AGR2 on EpCAM, adjacent to the TLIYY motif and surrounding EpCAM"s detergent binding site.	Hydrogen	0-8	epithelial cell adhesion molecule	Homo sapiens	152-157
29458127-4	2018	Employing hydrogen-deuterium exchange mass spectrometry, we reveal mechanisms underlying neuronal NOS activation by calmodulin and regulation by phosphorylation.	Hydrogen	10-18	calmodulin 1	Homo sapiens	116-126
29682188-4	2018	The aim of this study was to investigate the value of magnetic resonance spectroscopy (1H-MRS) of choline and diffusion-weighted magnetic resonance imaging (DW-MRI) as early markers of response to BRAF inhibition (BRAFi) with vemurafenib alone or in combination with MEK inhibition (MEKi) with trametinib, in BRAFi-sensitive and BRAFi-resistant melanoma xenografts.	Hydrogen	87-89	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	197-201
29528052-0	2018	High-resolution synchrotron terahertz investigation of the large-amplitude hydrogen bond librational band of (HCN)2.	Hydrogen	75-83	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	110-115
29466773-8	2018	The predicted hydrogen bond interaction formed by a small molecule inhibitor with mutant Ser797 is available to design the fourth-generation EGFR-TKIs.	Hydrogen	14-22	epidermal growth factor receptor	Homo sapiens	141-145
29779270-8	2018	The CAT levels significantly increased at 6 and 12 h in the hydrogen-rich medium as compared with the normal medium group (P&lt;0.05, P&lt;0.01, respectively).	Hydrogen	60-68	catalase	Homo sapiens	4-7
29510055-6	2018	Critical insight reveals that the observed plane specificity is strongly correlated with the number and their instantaneous fluctuations of clathrate water forming hydrogen bonds with both ice binding surface (IBS) of AFP and ice surface, thus anchoring AFP to the ice surface.	Hydrogen	164-172	alpha fetoprotein	Homo sapiens	218-221
29510055-6	2018	Critical insight reveals that the observed plane specificity is strongly correlated with the number and their instantaneous fluctuations of clathrate water forming hydrogen bonds with both ice binding surface (IBS) of AFP and ice surface, thus anchoring AFP to the ice surface.	Hydrogen	164-172	alpha fetoprotein	Homo sapiens	254-257
29261513-0	2018	High-content hydrogen water-induced downregulation of miR-136 alleviates non-alcoholic fatty liver disease by regulating Nrf2 via targeting MEG3.	Hydrogen	13-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	121-125
29557445-7	2018	Metal ion-mediated (de)stabilization of Abeta oligomers (or fibrils) is attributed to the critical effect of the metal ion on the beta-sheet rich crystalline structure of the amyloid aggregate and the status of hydrogen bonds within the aggregate.	Hydrogen	211-219	amyloid beta precursor protein	Homo sapiens	40-45
29554910-9	2018	While, the main mechanisms of KOS and PGM interactions are hydrogen bondings and hydrophobic interactions in pH 7.4 condition and were hydrogen bondings at pH 4.5.	Hydrogen	135-143	ubiquitin protein ligase E3B	Homo sapiens	30-33
29554910-8	2018	The binding between KTN and porcine gastric mucin (PGM) is dominated by electrostatic attractions and hydrogen bondings at pH 4.5, and disulfide bonds also plays a key role in the interaction at pH 7.4.	Hydrogen	102-110	keratocan	Homo sapiens	20-23
29554910-9	2018	While, the main mechanisms of KOS and PGM interactions are hydrogen bondings and hydrophobic interactions in pH 7.4 condition and were hydrogen bondings at pH 4.5.	Hydrogen	59-67	ubiquitin protein ligase E3B	Homo sapiens	30-33
29421573-4	2018	Molecular docking showed that 8d can form four hydrogen bonds with EGFR, and two of them were located in the Asp855-Phe856-Gly857 (DFG) motif of EGFR.	Hydrogen	47-55	epidermal growth factor receptor	Homo sapiens	67-71
29549268-0	2018	Sites associated with Kalydeco binding on human Cystic Fibrosis Transmembrane Conductance Regulator revealed by Hydrogen/Deuterium Exchange.	Hydrogen	112-120	CF transmembrane conductance regulator	Homo sapiens	48-99
29549268-4	2018	In this study we use hydrogen/deuterium exchange (HDX) coupled with mass spectrometry to assess the conformational dynamics of a thermostabilized form of CFTR in apo and ligand-bound states.	Hydrogen	21-29	CF transmembrane conductance regulator	Homo sapiens	154-158
29568538-13	2018	Results: Inhalation of hydrogen gas abrogated ovalbumin-induced the increase in lung resistance.	Hydrogen	23-31	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	46-55
29488528-4	2018	The formation of appropriate hydrogen bonds between strong nucleophilic amino acids and phenol is essential for the smooth reaction of the SN2 nucleophilic substitution.	Hydrogen	29-37	solute carrier family 38 member 5	Homo sapiens	139-142
29488528-5	2018	The SN2 mechanism hypothesis involving a hydrogen bond-assisted process was also supported by the density functional theory (DFT) analysis.	Hydrogen	41-49	solute carrier family 38 member 5	Homo sapiens	4-7
29564150-14	2018	Through interactions such as hydrogen bonding between Go and the Rig-loaded GO-hydrogel beads, the bead-loaded microfluidic device supported MC3T3 proliferation and development as osteoblast without additional osteogenic differentiation supplements.	Hydrogen	29-37	DIRAS family, GTP-binding RAS-like 1	Mus musculus	65-68
29504565-2	2018	The three crystal structures reported herein in the space groups P212121, I-4 and Pccn are defined solely by strong charge-assisted N-H...O hydrogen bonds and contain disordered guests (water and dimethylformamide) that vary in size, shape and degree of hydrophilicity.	Hydrogen	140-148	PPP1R2C family member C	Homo sapiens	74-77
30966305-5	2018	Due to the synergistic interactions of pi-pi stacking and hydrogen bonding between the nanofillers and SPI chains, the tensile strength of SPI/G/CNT/NFC film significantly increased by 78.9% and the water vapor permeability decreased by 31.76% in comparison to neat SPI film.	Hydrogen	58-66	chromogranin A	Homo sapiens	103-106
30966305-5	2018	Due to the synergistic interactions of pi-pi stacking and hydrogen bonding between the nanofillers and SPI chains, the tensile strength of SPI/G/CNT/NFC film significantly increased by 78.9% and the water vapor permeability decreased by 31.76% in comparison to neat SPI film.	Hydrogen	58-66	chromogranin A	Homo sapiens	139-142
30966305-5	2018	Due to the synergistic interactions of pi-pi stacking and hydrogen bonding between the nanofillers and SPI chains, the tensile strength of SPI/G/CNT/NFC film significantly increased by 78.9% and the water vapor permeability decreased by 31.76% in comparison to neat SPI film.	Hydrogen	58-66	chromogranin A	Homo sapiens	139-142
29570644-8	2018	The analysis of thermodynamic parameters and docking showed that hydrophobic, electrostatic forces and hydrogen bond are the responsible of Cpx-Lyz and Lev-Lyz associations.	Hydrogen	103-111	lysozyme	Homo sapiens	144-147
29570644-8	2018	The analysis of thermodynamic parameters and docking showed that hydrophobic, electrostatic forces and hydrogen bond are the responsible of Cpx-Lyz and Lev-Lyz associations.	Hydrogen	103-111	lysozyme	Homo sapiens	156-159
29295757-3	2018	Consequently, MECs stand as attractive post-treatment units to enhance the global H2 yield as a part of a two-stage, integrated application (DF-MEC).	Hydrogen	82-84	C-C motif chemokine ligand 28	Homo sapiens	14-17
29152682-8	2018	Interestingly, all the compounds in the agonist conformation of hERalpha formed a hydrogen bond with His524, while the compounds in the antagonist conformation formed a hydrogen bond with Thr347.	Hydrogen	82-90	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	64-72
29152682-8	2018	Interestingly, all the compounds in the agonist conformation of hERalpha formed a hydrogen bond with His524, while the compounds in the antagonist conformation formed a hydrogen bond with Thr347.	Hydrogen	169-177	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	64-72
29037677-4	2018	Moreover, the addition of modified SPI enhanced hydrogen bonding and disulphide linkages.	Hydrogen	48-56	chromogranin A	Homo sapiens	35-38
29306713-2	2018	Butyrate-type fermentation was the most appropriate fermentation type for the synergistic system and exhibited the accumulative hydrogen volume of 658.3 mL L-1 and hydrogen yield of 131.7 mL g-1 COD.	Hydrogen	128-136	immunoglobulin kappa variable 1-16	Homo sapiens	156-159
29175739-0	2018	One-pot aqueous fabrication of reduced graphene oxide supported porous PtAg alloy nanoflowers to greatly boost catalytic performances for oxygen reduction and hydrogen evolution.	Hydrogen	159-167	rhomboid domain containing 3	Homo sapiens	71-75
29593119-6	2018	According to the predicted binding modes, these molecules form two important hydrogen bonds with HIF1alpha.	Hydrogen	77-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-106
29414036-5	2018	Arg192 plays a major role in the binding of CYP3A4 with IMI based on its polarity and the hydrogen bond between the H atom in Arg192 side chain and the nitryl O atom of IMI.	Hydrogen	90-98	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	44-50
29266939-1	2018	Cytochrome P450 (CYP) monooxygenases catalyze the oxidation of chemically inert carbon-hydrogen bonds in diverse endogenous and exogenous organic compounds by atmospheric oxygen.	Hydrogen	87-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
29407982-4	2018	Docking studies revealed the capacity of this compound to occupy the selective COX-2 cavity establishing additional hydrogen bonds between the oxygen of the methoxy group and the His90 and Arg513 of the binding site of the enzyme.	Hydrogen	116-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
29473866-9	2018	The probable binding modes of the best active compounds with PPARgamma active site were analyzed, and the residues His323, Tyr473, Ser289 and Ser342 were found to have hydrogen bond interactions.	Hydrogen	168-176	peroxisome proliferator activated receptor gamma	Homo sapiens	61-70
29266939-1	2018	Cytochrome P450 (CYP) monooxygenases catalyze the oxidation of chemically inert carbon-hydrogen bonds in diverse endogenous and exogenous organic compounds by atmospheric oxygen.	Hydrogen	87-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
29393624-6	2018	The reaction of DMS with NO3  appears to proceed exclusively by hydrogen abstraction.	Hydrogen	64-72	NBL1, DAN family BMP antagonist	Homo sapiens	25-28
29227673-7	2018	Using in silico modeling of the Serp-1 RCL peptide, S-7, we designed several modified RCL peptides that were predicted to have stronger interactions with human serpins because of the larger number of stabilizing hydrogen bonds.	Hydrogen	212-220	stress associated endoplasmic reticulum protein 1	Homo sapiens	32-38
29462206-8	2018	Examination of the crystal structure of cell-free synthesized 059-152-Fv in complex with the extracellular domain of human EGFR revealed that the epitope of 059-152-Fv broadly covers the EGF binding surface on domain III, including residues that formed critical hydrogen bonds with EGF (Asp355EGFR, Gln384EGFR, H409EGFR, and Lys465EGFR), so that the antibody inhibited EGFR activation.	Hydrogen	262-270	epidermal growth factor receptor	Homo sapiens	123-127
29384536-4	2018	The as-prepared HCP-PPh3-Rh was used as an active catalyst for hydrogen generation from AB hydrolysis.	Hydrogen	63-71	caveolin 1	Homo sapiens	20-24
29091730-4	2018	Conversely, 1H NMR studies revealed that 2 equiv of AMA remove 2 equiv of Co(II) from Co(II)-substituted NDM-1, VIM-2, and IMP-7 when the MBL/AMA are at millimolar concentrations.	Hydrogen	12-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
29040928-1	2018	A quantitative analysis of the interaction between zidovudine (AZT) and human serum albumin (HSA) was achieved using Isothermal titration calorimetry (ITC) in combination with fluorescence and 1H NMR spectroscopy.	Hydrogen	193-195	albumin	Homo sapiens	78-97
30108955-8	2018	Compound 9d interacts with rVEGF through hydrogen bonds in silico, thereby down-regulating the expression of VEGF in angiogenesis.	Hydrogen	41-49	vascular endothelial growth factor A	Homo sapiens	28-32
29444082-7	2018	We found that S100B could interact with S100A1 via NMR 1H-15N HSQC titrations.	Hydrogen	55-57	S100 calcium binding protein B	Homo sapiens	14-19
29444082-7	2018	We found that S100B could interact with S100A1 via NMR 1H-15N HSQC titrations.	Hydrogen	55-57	S100 calcium binding protein A1	Homo sapiens	40-46
29229647-6	2018	Based on the crystal structure of the p38alpha-TAB1 complex we replaced threonine 185 of p38alpha with glycine (T185G) to prevent an intramolecular hydrogen bond with Asp150 from being formed.	Hydrogen	148-156	mitogen-activated protein kinase 14	Homo sapiens	38-46
29391000-13	2018	Moreover, molecular docking study of BA with PLA2 revealed that BA interacts with GLY22 &amp; GLY29 through hydrogen bond formation and LEU2, PHE5, HIS6, ALA17, ALA18, HIS47 and TYR51 through different types of hydrophobic interactions.	Hydrogen	108-116	phospholipase A2 group IB	Homo sapiens	45-49
29339254-9	2018	For the future optimization of the generated inhibitors, (i) antioxidant activity against SOD, (ii) the inhibitor stabilization by pi-cation interaction with the catalytic Fe+3 and (iii) formation of hydrogen bond with Ile 676 should be regarded.	Hydrogen	200-208	superoxide dismutase 1	Homo sapiens	90-93
29353723-8	2018	Docking simulation also demonstrated that active compound 1 created interaction with the Ser-288 (the catalytic amino-acid in the catalytic cavity) of hCE2 via hydrogen bonding, revealing its highly selective inhibition toward hCE2.	Hydrogen	160-168	carboxylesterase 2	Homo sapiens	151-155
29353723-8	2018	Docking simulation also demonstrated that active compound 1 created interaction with the Ser-288 (the catalytic amino-acid in the catalytic cavity) of hCE2 via hydrogen bonding, revealing its highly selective inhibition toward hCE2.	Hydrogen	160-168	carboxylesterase 2	Homo sapiens	227-231
29301085-5	2018	An intramolecular hydrogen bond to an indole NH was also effective in locking the carboxamide in the preferred bound conformation to CHK1.	Hydrogen	18-26	checkpoint kinase 1	Homo sapiens	133-137
29258818-5	2018	Here we used hydrogen exchange mass spectrometry (HX MS) to compare the solution conformation of Nef alone and in complexes with the SH3 or the SH3-SH2 domains of the Src-family kinase Hck.	Hydrogen	13-21	S100 calcium binding protein B	Homo sapiens	97-100
29396789-4	2018	By tuning the content of Ni2P, H2 generation rates of 43.3 muM h- 1 (1 mg photocatalyst) and 700 muM h- 1 (100 mg photocatalyst) and a solar to hydrogen efficiency of 1.5% were achieved for the Ni2P-Cd0.5Zn0.5S composites.	Hydrogen	31-33	latexin	Homo sapiens	59-62
29396789-4	2018	By tuning the content of Ni2P, H2 generation rates of 43.3 muM h- 1 (1 mg photocatalyst) and 700 muM h- 1 (100 mg photocatalyst) and a solar to hydrogen efficiency of 1.5% were achieved for the Ni2P-Cd0.5Zn0.5S composites.	Hydrogen	31-33	latexin	Homo sapiens	97-100
29396789-4	2018	By tuning the content of Ni2P, H2 generation rates of 43.3 muM h- 1 (1 mg photocatalyst) and 700 muM h- 1 (100 mg photocatalyst) and a solar to hydrogen efficiency of 1.5% were achieved for the Ni2P-Cd0.5Zn0.5S composites.	Hydrogen	144-152	latexin	Homo sapiens	97-100
28560519-10	2018	Fasting serum insulin levels dropped by 5.4% after H2 administration, while placebo intervention augmented insulin response by 29.3% (P = 0.01).	Hydrogen	51-53	insulin	Homo sapiens	14-21
29431095-4	2018	RESULTS: In this work, a measure of hydrogen bond stability in conformational states was studied with elastic network analysis of 35 SOD1 mutants.	Hydrogen	36-44	superoxide dismutase 1	Homo sapiens	133-137
29431095-6	2018	These hydrogen bonds were formed by the amino acid residues known from the literature to be located in contact between SOD1 aggregates.	Hydrogen	6-14	superoxide dismutase 1	Homo sapiens	119-123
28967043-5	2018	FT-IR spectroscopy revealed hydrogen bond interactions between carvedilol and copovidone K28.	Hydrogen	28-36	keratin 28	Homo sapiens	89-92
28869340-1	2018	AIM: The aim of this study was to evaluate the diagnostic utility of high-sensitivity cardiac troponin T (hs-cTnT) levels in discriminating cardiac amyloidosis from patients with cardiac hypertrophy caused by aetiologies other than cardiac amyloidosis.	Hydrogen	106-108	troponin T2, cardiac type	Homo sapiens	109-113
29269206-0	2018	Reduced insulin sensitivity may be related to less striatal glutamate: An 1H-MRS study in healthy non-obese humans.	Hydrogen	74-76	insulin	Homo sapiens	8-15
29368926-2	2018	Macrocyclic tetrapyridyl ligands (pyrphyrins) and their CoII complexes emerged in this context as a highly efficient class of H2 evolution catalysts.	Hydrogen	126-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-60
31938167-9	2018	This present study demonstrates that comparatively conservative intraspecific genetic variations of E. multilocularis exist in Xinjiang Uyghur Autonomous Region and the main epidemic haplotypes in Xinjiang are H1 (cox1) and H1 (cytb).	Hydrogen	210-212	COX1	Echinococcus multilocularis	214-218
29283197-6	2018	SLS prefers to bind to the interface of CAT mainly via van der Waals" forces and hydrogen bonds.	Hydrogen	81-89	catalase	Homo sapiens	40-43
29425536-12	2018	Secretion of IFNg was also increased when particles were added to the cells as early as 1h.	Hydrogen	88-90	interferon gamma	Homo sapiens	13-17
28560519-11	2018	CONCLUSIONS: It appears that orally administered H2 as a blend of hydrogen-generating minerals might be a beneficial agent in the management of body composition and insulin resistance in obesity.	Hydrogen	49-51	insulin	Homo sapiens	165-172
28560519-11	2018	CONCLUSIONS: It appears that orally administered H2 as a blend of hydrogen-generating minerals might be a beneficial agent in the management of body composition and insulin resistance in obesity.	Hydrogen	66-74	insulin	Homo sapiens	165-172
30023799-6	2018	In silico analysis depicted the role of Sod1, Sod2, p53, and VLDR proteins-TiO2 hydrogen bond interaction having a key role in determining the cytotoxicity.	Hydrogen	80-88	superoxide dismutase 1	Homo sapiens	40-44
28433002-4	2018	In addition, the strength of hydrogen bond interaction between + N-H and NO3- is stronger than that between + N-H and Ac- , suggesting that anions have a significant influence on microstructure due to the acidity of a Bronsted acid.	Hydrogen	29-37	NBL1, DAN family BMP antagonist	Homo sapiens	73-76
29327911-7	2018	These are the key factors for the improved hydrogen evolution ability of CN-P than that of pure carbon nitride.	Hydrogen	43-51	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	73-77
29323492-2	2018	The key steps of the synthesis include a highly stereoselective SmI2-mediated cyclization to establish the eight-membered ring and a stereospecific transannular [1,5]-hydrogen atom transfer to set the C10 stereocenter.	Hydrogen	167-175	homeobox C10	Homo sapiens	201-204
28983974-5	2018	Structural analysis revealed that peptide N-terminus and hydrogen bonds play important roles in the peptide interaction stability and specificity with Brd2 and Brd4.	Hydrogen	57-65	bromodomain containing 4	Homo sapiens	160-164
29098725-0	2018	The structure of the large regulatory alpha subunit of phosphorylase kinase examined by modeling and hydrogen-deuterium exchange.	Hydrogen	101-109	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	55-75
29098725-8	2018	The overall highly helical structure with several intervening hinge regions is consistent with our hydrogen-deuterium exchange results obtained for this subunit as part of the (alphabetagammadelta)4 PhK complex.	Hydrogen	99-107	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	199-202
28632510-12	2018	In addition, H2 alleviates ALI in septic mice through downregulating the expression of Sema 7A, OTULIN, and MAP3K1 as well as upregulating the expression of Transferrin.	Hydrogen	13-15	sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A	Mus musculus	87-94
28632510-12	2018	In addition, H2 alleviates ALI in septic mice through downregulating the expression of Sema 7A, OTULIN, and MAP3K1 as well as upregulating the expression of Transferrin.	Hydrogen	13-15	mitogen-activated protein kinase kinase kinase 1	Mus musculus	108-114
29308820-4	2018	The solution viscosity, deuterium kinetic isotope effect (KIE), and oxygen-18 KIE experiments further demonstrate that NO activates COX-2 by altering the protein conformation to stimulate substrate association/product release and by accelerating the rate of hydrogen abstraction from AA by catalytic tyrosine radicals.	Hydrogen	258-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
29434596-9	2018	Lysine-to-alanine mutations at the PI-binding residues abolished TIRAP"s affinity for PIP2; however, K34, K35, and R36 consistently interacted with PIP2 headgroups through hydrogen bond (H-bond) and electrostatic interactions.	Hydrogen	172-180	keratin 34	Homo sapiens	101-104
29240988-8	2018	The homolytic aromatic substitution reactions do not require a sacrificial or substrate-derived oxidant because the CoII by-product of CoIII -CF3 homolysis produces H2 .	Hydrogen	165-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-120
29240988-8	2018	The homolytic aromatic substitution reactions do not require a sacrificial or substrate-derived oxidant because the CoII by-product of CoIII -CF3 homolysis produces H2 .	Hydrogen	165-167	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	135-140
29371621-6	2018	Most importantly, based on the simulation observation that resveratrol has a high probability of forming hydrogen bonds with sn-1 and sn-2 ester groups, we discovered a new mechanism using experimental approach, in which resveratrol protects both sn-1 and sn-2 ester bonds of DPPC and distearoyl phosphatidylcholine (DSPC) from phospholipase A1 (PLA1) and phospholipase A2 (PLA2) cleavage.	Hydrogen	105-113	phospholipase A2 group IB	Homo sapiens	356-372
29288664-0	2018	Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway.	Hydrogen	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	127-130
29297222-0	2018	Self-Supported Ternary Ni-S-Se Nanorod Arrays as Highly Active Electrocatalyst for Hydrogen Generation in Both Acidic and Basic Media: Experimental Investigation and DFT Calculation.	Hydrogen	83-91	solute carrier family 5 member 5	Homo sapiens	23-27
29210412-9	2018	Results confirmed that the higher inhibitory potency of NCW might be attributed to the formation of more hydrogen bonds with the ACE"s active site.	Hydrogen	105-113	angiotensin I converting enzyme	Homo sapiens	129-132
29260180-1	2018	Several complexes of Co(ii) or Fe(ii) with 1,4,7,10-tetraazacyclododecane (CYCLEN) appended with 1,7-(6-methyl)2-picolyl groups are studied as 1H NMR paraSHIFT agents (paramagnetic shift agents) for the registration of temperature.	Hydrogen	143-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
29154477-0	2018	Mutagenesis of Sequence Determinants of Truncated Porcine ALOX15 Induces Changes in the Reaction Specificity by Altering the Catalytic Mechanism of Initial Hydrogen Abstraction.	Hydrogen	156-164	arachidonate 15-lipoxygenase	Homo sapiens	58-64
29260852-19	2018	Protection of backbone hydrogen bonds (BHBs) has been shown to be an important factor for the stability of amyloidogenic proteins and was employed to identify and stabilize the structural defect resulting from the p53 Y220C mutation.	Hydrogen	23-31	tumor protein p53	Homo sapiens	214-217
29260180-1	2018	Several complexes of Co(ii) or Fe(ii) with 1,4,7,10-tetraazacyclododecane (CYCLEN) appended with 1,7-(6-methyl)2-picolyl groups are studied as 1H NMR paraSHIFT agents (paramagnetic shift agents) for the registration of temperature.	Hydrogen	143-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-26
29260180-5	2018	The 1H NMR spectra of both of the Fe(ii) complexes and one of the Co(ii) complexes are consistent with a predominant diastereomeric form in deuterium oxide solutions.	Hydrogen	4-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-39
29260180-5	2018	The 1H NMR spectra of both of the Fe(ii) complexes and one of the Co(ii) complexes are consistent with a predominant diastereomeric form in deuterium oxide solutions.	Hydrogen	4-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
29198702-0	2018	Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway.	Hydrogen	0-8	AKT serine/threonine kinase 1	Homo sapiens	114-117
28843881-5	2018	Thermodynamic data (DeltaS=+12.82Jmol-1K-1; DeltaH=-16.73kJmol-1) of VDB-LYZ interaction revealed participation of hydrophobic and van der Waals forces along with hydrogen bonds in VDB-LYZ complexation.	Hydrogen	163-171	lysozyme	Homo sapiens	73-76
29198702-0	2018	Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway.	Hydrogen	0-8	forkhead box O3	Homo sapiens	118-124
29198702-11	2018	Furthermore, the protective effects of hydrogen were abrogated by PI3K/Akt inhibitor LY294002.	Hydrogen	39-47	AKT serine/threonine kinase 1	Homo sapiens	71-74
29155465-5	2018	The proposed reaction mechanism involves intramolecular hydrogen atom transfer (HAT) to CoIII -carbene radical intermediates followed by dissociation of an ortho-quinodimethane that undergoes 8pi cyclization.	Hydrogen	56-64	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	88-93
29926661-7	2018	Compared with CIH group, the pathology of liver microstructure were significantly improved and the serum levels of ALT, AST were significantly lower in H2+CIH group (P&lt;0.05); the serum levels of 8-OHdG and IL-6 were significantly lower, the serum level of SOD was significantly higher.	Hydrogen	152-154	interleukin 6	Rattus norvegicus	209-213
29643308-4	2018	Multiple interactions, including hydrophobic interaction, pi-pi interactions, electrostatic interactions and hydrogen bonding, were involved due to the synergism of the C18 chain and RCC3.	Hydrogen	109-117	Bardet-Biedl syndrome 9	Homo sapiens	169-172
33562904-8	2018	ATR-FTIR results evidenced hydrogen bonding interactions between both the drugs.	Hydrogen	27-35	ATR serine/threonine kinase	Homo sapiens	0-3
29173945-8	2018	The molecular modeling studies revealed that the potent TNF-alpha production inhibitory activity 5v due to the extra stability of complex because of an extra pi-pi (pi-pi) stacking, hydrogen-bonding interactions.	Hydrogen	182-190	tumor necrosis factor	Homo sapiens	56-65
29564983-7	2018	RESULTS: Ligplot analysis indicated that abietic acid had strong binding efficiency with AchE and HDAC3 receptors forming one and four hydrogen bonds respectively.	Hydrogen	135-143	acetylcholinesterase (Cartwright blood group)	Homo sapiens	89-93
29763919-15	2018	The expression levels of Cox8b, Cox6a2, Cox7a1, Hspb7, and Atp2a1 were inhibited by hydrogen treatment.	Hydrogen	84-92	cytochrome c oxidase subunit 6A2	Mus musculus	32-38
29763919-15	2018	The expression levels of Cox8b, Cox6a2, Cox7a1, Hspb7, and Atp2a1 were inhibited by hydrogen treatment.	Hydrogen	84-92	heat shock protein family, member 7 (cardiovascular)	Mus musculus	48-53
29763919-19	2018	Cox8b, Cox6a2, Cox7a1, Hspb7, and Atp2a1 were identified as potential target genes of hydrogen treatment.	Hydrogen	86-94	cytochrome c oxidase subunit 6A2	Mus musculus	7-13
29763919-19	2018	Cox8b, Cox6a2, Cox7a1, Hspb7, and Atp2a1 were identified as potential target genes of hydrogen treatment.	Hydrogen	86-94	heat shock protein family, member 7 (cardiovascular)	Mus musculus	23-28
29660927-1	2018	It is proposed that the specific reversal by serum albumin of the erythrocyte echinocytosis in an inorganic phosphate buffer saline or in a saline, either after 24 h in blood or after a storage of 6-7 weeks in SGAM or PAGGSM media, is due to a cell dehydration by a decrease of the total NaCl and KCl concentrations favoring the stomatocytogenic slow outward transport of inorganic phosphate with a hydrogen ion by band 3 anion exchanger, which was previously proposed to control the erythrocyte shape.	Hydrogen	399-407	albumin	Homo sapiens	51-58
29207336-6	2018	Docking simulation studies against the two proteins EGFR and DHFR demonstrate that compound 8 showed higher binding affinity toward the two proteins more than compound 5, suggesting that trimethoxy groups may be responsible for this higher activity through the formation of five hydrogen bonding with the active domain (4r3r) and other four interactions with the active domain (1dls).	Hydrogen	279-287	epidermal growth factor receptor	Homo sapiens	52-56
29080206-0	2018	Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.	Hydrogen	104-112	trinucleotide repeat containing adaptor 6A	Homo sapiens	27-32
28113517-7	2018	Applying 1H-15N Heteronuclear Single Quantum Coherence NMR measurements, we determined the putative regions at IL-8 that are potentially responsible for interactions with the pepsin.	Hydrogen	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
28081663-6	2018	This study focuses on analyses of 153 BACE1-ligand complexes for the direct contacts (hydrogen bonds and weak interactions) observed between protein and ligand and indirect contacts (water-mediated hydrogen bonds), observed in BACE1-ligand complex crystal structures.	Hydrogen	86-94	beta-secretase 1	Homo sapiens	38-43
29197725-5	2018	We confirmed that ASP103 of Bcl-2 is a key residue and that hydrogen bonding between ASP103 and ABT-199 confers the Bcl-2 selectivity of this inhibitor.	Hydrogen	60-68	BCL2 apoptosis regulator	Homo sapiens	116-121
28081663-6	2018	This study focuses on analyses of 153 BACE1-ligand complexes for the direct contacts (hydrogen bonds and weak interactions) observed between protein and ligand and indirect contacts (water-mediated hydrogen bonds), observed in BACE1-ligand complex crystal structures.	Hydrogen	198-206	beta-secretase 1	Homo sapiens	38-43
28081663-6	2018	This study focuses on analyses of 153 BACE1-ligand complexes for the direct contacts (hydrogen bonds and weak interactions) observed between protein and ligand and indirect contacts (water-mediated hydrogen bonds), observed in BACE1-ligand complex crystal structures.	Hydrogen	198-206	beta-secretase 1	Homo sapiens	227-232
28100151-5	2018	The results of docking simulation and hydrogen bond pattern show that this ligand is able to bind to the active site of renin and a region near the active site.	Hydrogen	38-46	renin	Homo sapiens	120-125
28590011-0	2018	AKT as Locus of Hydrogen Bond Network in Cancer.	Hydrogen	16-24	AKT serine/threonine kinase 1	Homo sapiens	0-3
28590011-3	2018	Hyperactivated AKT locus by a positive feedback loops from the cancer hypoxic microenvironment generates a hydrogen bond network.	Hydrogen	107-115	AKT serine/threonine kinase 1	Homo sapiens	15-18
28590011-5	2018	A hydrogen bond network conforms an entropy/enthalpy energetic process used for the interconversion of the AKT protein in metastasis formation and maintenance.	Hydrogen	2-10	AKT serine/threonine kinase 1	Homo sapiens	107-110
28590011-6	2018	Targeting the AKT locus by the redox balance change or hydrogen balance change or proton beam radiation disrupts a hydrogen bond network leading to the disappearance of a cancer complexity and robustness causing failure of the complex energy system in solid cancers and hematological malignancy.	Hydrogen	55-63	AKT serine/threonine kinase 1	Homo sapiens	14-17
28590011-6	2018	Targeting the AKT locus by the redox balance change or hydrogen balance change or proton beam radiation disrupts a hydrogen bond network leading to the disappearance of a cancer complexity and robustness causing failure of the complex energy system in solid cancers and hematological malignancy.	Hydrogen	115-123	AKT serine/threonine kinase 1	Homo sapiens	14-17
29406112-6	2018	Kinetic studies coupled with competitive testing using 3 known inhibitors indicated that six of the C60 NPs, of greater hydrophobicity and hydrogen bond (HB) donor acidity or acceptor basicity, acted as competitive inhibitors of thrombin by directly interacting with the active site of thrombin.	Hydrogen	139-147	coagulation factor II, thrombin	Homo sapiens	229-237
29135326-0	2018	Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction.	Hydrogen	0-8	TNF superfamily member 15	Homo sapiens	119-123
30504623-6	2018	Circular dichroism (CD) spectra of lysozyme revealed that the secondary structure was denatured by g-STO:Rh photocatalysis, indicating that g-STO:Rh photocatalysis is especially effective against the amino acid residues that form the secondary structure via hydrogen bonds.	Hydrogen	258-266	lysozyme	Homo sapiens	35-43
29135326-5	2018	Here, we report on the use of hydrogen/deuterium exchange mass spectrometry (HDX-MS) to obtain molecular-level details of mAb1"s binding epitope on TL1A.	Hydrogen	30-38	TNF superfamily member 15	Homo sapiens	148-152
28585088-7	2018	The binding efficacy of AITC with AhR and Nrf2 analysis by molecular docking studies reveals that AITC has strong interaction with AhR and Nrf2 proteins through hydrogen and hydrophobic interactions.	Hydrogen	161-169	NFE2 like bZIP transcription factor 2	Rattus norvegicus	139-143
28240384-2	2018	Many studies have also shown the various therapeutic effects of H2 S, which include protection against myocardial ischemia injury, cytoprotection against oxidative stress, mediation of neurotransmission, inhibition of insulin signaling, regulation of inflammation, inhibition of the hypoxia-inducible pathway, and dilation of blood vessels.	Hydrogen	64-66	insulin	Homo sapiens	218-225
28585088-7	2018	The binding efficacy of AITC with AhR and Nrf2 analysis by molecular docking studies reveals that AITC has strong interaction with AhR and Nrf2 proteins through hydrogen and hydrophobic interactions.	Hydrogen	161-169	NFE2 like bZIP transcription factor 2	Rattus norvegicus	42-46
30906767-7	2018	We used a combination of X-ray crystallography and hydrogen/deuterium exchange (HDX) to elucidate the structural basis for reduced activation of PPARgamma by SR1988.	Hydrogen	51-59	peroxisome proliferator activated receptor gamma	Homo sapiens	145-154
30099452-7	2018	The docking results revealed that compound 8 forms 2 hydrogen bonds with the residues of Gly-216 and Ile-218 in 11beta-HSD1, that is to say compound 8 maybe a good 11beta-HSD1 inhibitor.	Hydrogen	53-61	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	112-123
29380956-7	2018	Change in Bcl-2 phosphorylation at 1H was significantly greater in PL compared to CON (P = 0.001).	Hydrogen	35-37	BCL2 apoptosis regulator	Homo sapiens	10-15
29380956-9	2018	The change in JNK phosphorylation was significantly greater in PPB (P = 0.009), and PL (P = 0.017) compared to CON at 1H, while the change for PL was elevated compared to CON at 5H (P = 0.002).	Hydrogen	118-120	mitogen-activated protein kinase 8	Homo sapiens	14-17
30099452-7	2018	The docking results revealed that compound 8 forms 2 hydrogen bonds with the residues of Gly-216 and Ile-218 in 11beta-HSD1, that is to say compound 8 maybe a good 11beta-HSD1 inhibitor.	Hydrogen	53-61	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	164-175
29037842-6	2017	Pre-treatment with puerarin (50-200muM) for 1h significantly attenuated the ox-LDL-induced TF expression, augmented the phosphorylation of Akt, with a resultant increase of the NO production, and inhibited the activation of ERK1/2 and NF-kappaB (P&lt;0.01).	Hydrogen	44-46	AKT serine/threonine kinase 1	Homo sapiens	139-142
29336242-9	2018	RESULTS: Changes in the values of the 1H NMR chemical shift [ppm] are evidence of interaction between MTP, fatted (HSA) and defatted (dHSA) human serum albumin.	Hydrogen	38-40	albumin	Homo sapiens	146-159
29141117-3	2018	Thus, in a methylcyclohexane/toluene (MCH/Tol) mixture, intramolecular hydrogen-bonding interactions in the peripheral side units favor the formation of metastable inactivated monomers that evolve with time at precise conditions of concentration and temperature.	Hydrogen	71-79	pro-melanin concentrating hormone	Homo sapiens	38-41
29097029-4	2017	In both the crystal and solution states, the conformations of [Pro]ASC, [Aze]ASC and [DeltaPro]ASC were novel square structures having two trans imide bonds and stabilized by two intramolecular hydrogen bonds.	Hydrogen	194-202	PYD and CARD domain containing	Homo sapiens	67-70
29097029-4	2017	In both the crystal and solution states, the conformations of [Pro]ASC, [Aze]ASC and [DeltaPro]ASC were novel square structures having two trans imide bonds and stabilized by two intramolecular hydrogen bonds.	Hydrogen	194-202	PYD and CARD domain containing	Homo sapiens	77-80
29097029-4	2017	In both the crystal and solution states, the conformations of [Pro]ASC, [Aze]ASC and [DeltaPro]ASC were novel square structures having two trans imide bonds and stabilized by two intramolecular hydrogen bonds.	Hydrogen	194-202	PYD and CARD domain containing	Homo sapiens	77-80
28939339-5	2017	Molecular docking studies revealed that zinc ion coordination, hydrogen bonding and hydrophobic interactions contributed to the high calculated binding affinities of these compounds toward HDAC2 and that His145, His146, Gly154, Glu103, His183, Asp104, Tyr308 and Phe155 contributed favorably to the binding.	Hydrogen	63-71	histone deacetylase 2	Homo sapiens	189-194
28875702-8	2017	Kinetic studies of the isomerization from HH-1 to HH-2 and the racemization of enantiomerically pure HH-2 were conducted based on 1H NMR spectroscopy, HPLC analysis, and DFT calculations.	Hydrogen	130-132	anosmin 1	Homo sapiens	42-54
29262362-3	2017	Here, we describe 1H-detected magic angle spinning solid-state NMR studies of monomeric IL-8 (1-66) bound to full-length and truncated constructs of CXCR1 in phospholipid bilayers under physiological conditions.	Hydrogen	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
29140083-3	2017	Computational studies of the most pathologic form of Abeta, the 42-residue Abeta42 peptide, have suggested that hydrogen bonding involving Ser26 may be particularly important in organizing a monomer folding nucleus and in subsequent peptide assembly.	Hydrogen	112-120	amyloid beta precursor protein	Homo sapiens	53-58
29282447-2	2017	These methods describe both the quantization of vibrational modes as well as tunneling and are applied to the  H + H2 and  H + CH4 reactions.	Hydrogen	115-117	COP9 signalosome subunit 4	Drosophila melanogaster	127-130
29216268-4	2017	Most of the studied compounds adopted similar orientations within the PDE3A active site, establishing hydrogen bonds with catalytic amino acids.	Hydrogen	102-110	phosphodiesterase 3A	Homo sapiens	70-75
29083921-7	2017	The simulations highlight a remarkable harmonicity of the Pt-Pt oscillation, while also showing clear signs of Pt-H hydrogen bonding and directional coordination of water molecules along the Pt-Pt axis of the complex.	Hydrogen	116-124	parathyroid hormone	Homo sapiens	111-115
28972185-6	2017	We show that the gating brake assumes a helical conformation upon binding CaM, with associated conformational changes to both CaM lobes as indicated by amide chemical shifts of the amino acids of CaM in 1H-15N HSQC NMR spectra.	Hydrogen	203-205	calmodulin 1	Homo sapiens	74-77
28972185-6	2017	We show that the gating brake assumes a helical conformation upon binding CaM, with associated conformational changes to both CaM lobes as indicated by amide chemical shifts of the amino acids of CaM in 1H-15N HSQC NMR spectra.	Hydrogen	203-205	calmodulin 1	Homo sapiens	126-129
28972185-6	2017	We show that the gating brake assumes a helical conformation upon binding CaM, with associated conformational changes to both CaM lobes as indicated by amide chemical shifts of the amino acids of CaM in 1H-15N HSQC NMR spectra.	Hydrogen	203-205	calmodulin 1	Homo sapiens	126-129
29116795-1	2017	Reactions of hydrogen atoms with small sulfur-containing anions, SCN-, CH3COS-, C6H5COS-, -SCH2COOH, C6H5S-, 2-HOOCC6H4S-, and related oxygen-containing anions, OCN-, CH3COO-, C6H5COO-, HOCH2COO-, C6H5O-, 2-HOOCC6H4O-, have been studied both experimentally and computationally.	Hydrogen	13-21	bone gamma-carboxyglutamate protein	Homo sapiens	161-164
28926473-9	2017	Moreover, hydrogen gas suppressed NF-kappaB phosphorylation and nuclear translocation and reduced the production of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha following sevoflurane administration.	Hydrogen	10-18	interleukin 1 beta	Rattus norvegicus	116-133
29207575-5	2017	Molecular docking studies were subsequently performed to deduce the affinity and binding mode of derived halophenols toward the Keap1 Kelch domain, the docking results exhibited that the small molecule 22b is well accommodated by the bound region of Keap1-Kelch and Nrf2 through stable hydrogen bonds and hydrophobic interaction, which contributed to the enhancement of affinity and stability between the ligand and receptor.	Hydrogen	286-294	kelch like ECH associated protein 1	Homo sapiens	128-133
28926473-9	2017	Moreover, hydrogen gas suppressed NF-kappaB phosphorylation and nuclear translocation and reduced the production of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha following sevoflurane administration.	Hydrogen	10-18	interleukin 6	Rattus norvegicus	135-181
29099587-2	2017	To derive the protein complex of the DNA-repair enzyme human uracil-DNA-glycosylase (hUNG) with its protein inhibitor (UGI), we combined rigid-body computational docking with hydrogen/deuterium exchange mass spectrometry (DXMS).	Hydrogen	175-183	uracil DNA glycosylase	Homo sapiens	61-83
29099587-2	2017	To derive the protein complex of the DNA-repair enzyme human uracil-DNA-glycosylase (hUNG) with its protein inhibitor (UGI), we combined rigid-body computational docking with hydrogen/deuterium exchange mass spectrometry (DXMS).	Hydrogen	175-183	uracil DNA glycosylase	Homo sapiens	85-89
29207575-5	2017	Molecular docking studies were subsequently performed to deduce the affinity and binding mode of derived halophenols toward the Keap1 Kelch domain, the docking results exhibited that the small molecule 22b is well accommodated by the bound region of Keap1-Kelch and Nrf2 through stable hydrogen bonds and hydrophobic interaction, which contributed to the enhancement of affinity and stability between the ligand and receptor.	Hydrogen	286-294	kelch like ECH associated protein 1	Homo sapiens	250-255
28895240-5	2017	It is demonstrated that the disruption and partial recovery of the hydrogen bonds, combined with the conformational change of PEO chains, can contribute to this irreversible behavior as well as a conversion to reversible phase transition behavior.	Hydrogen	67-75	twinkle mtDNA helicase	Homo sapiens	126-129
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Hydrogen	120-128	CD4 molecule	Homo sapiens	59-62
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Hydrogen	120-128	CD4 molecule	Homo sapiens	154-157
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Hydrogen	120-128	CD4 molecule	Homo sapiens	154-157
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Hydrogen	120-128	CD4 molecule	Homo sapiens	154-157
28962916-7	2017	The phosphorylation levels of ezrin (Thr567), which is suggested to act as a signaling bridge between the cellular membrane receptors and actin cytoskeleton, were strongly enhanced by IGF-I at both 1h and 24h (p &lt; 0.05; p &lt; 0.01).	Hydrogen	198-200	insulin like growth factor 1	Homo sapiens	184-189
28677244-9	2017	Five of nine phthalate compounds and cortisol shared a hydrogen bonding interaction with the Arg-252 residue of CBG.	Hydrogen	55-63	serpin family A member 6	Homo sapiens	112-115
28941985-10	2017	The plasma levels of norepinephrine, BNP, Ang-II were increased 1h after myocardial infarction while the increase was attenuated by GPS.	Hydrogen	64-66	natriuretic peptide B	Canis lupus familiaris	37-40
29200586-7	2017	At a bicarbonate concentration of 50 mmol L-1, current density increased to 10.7 A m-2 at an anode potential of -0.2 V. This increase in current density could be due to oxidation of formed acetate in addition to oxidation of hydrogen, or enhanced growth of hydrogen oxidizing bacteria due to the availability of acetate as carbon source.	Hydrogen	225-233	immunoglobulin kappa variable 1-16	Homo sapiens	42-45
29200586-7	2017	At a bicarbonate concentration of 50 mmol L-1, current density increased to 10.7 A m-2 at an anode potential of -0.2 V. This increase in current density could be due to oxidation of formed acetate in addition to oxidation of hydrogen, or enhanced growth of hydrogen oxidizing bacteria due to the availability of acetate as carbon source.	Hydrogen	257-265	immunoglobulin kappa variable 1-16	Homo sapiens	42-45
29073504-3	2017	As a practical example the dissolution of hydrogen gas in the liquid and the PHIP kinetics during the hydrogenation reaction of Fmoc-O-propargyl-l-tyrosine in acetone-d6 are monitored.	Hydrogen	42-50	pleckstrin homology domain interacting protein	Homo sapiens	77-81
28289968-4	2017	PROCEDURES: [3H]LRRK2-IN-1 was prepared with high radiochemical purity (&gt;99 %) and a specific activity of 41 Ci/mmol via tritium/hydrogen (T/H) exchange using Crabtree"s catalyst.	Hydrogen	132-140	leucine rich repeat kinase 2	Homo sapiens	16-21
29123019-2	2017	Herein we demonstrate that a photoredox-mediated hydrogen atom transfer protocol can efficiently and selectively install deuterium (D) and tritium (T) at alpha-amino sp3 carbon-hydrogen bonds in a single step, using isotopically labeled water (D2O or T2O) as the source of hydrogen isotope.	Hydrogen	49-57	Sp3 transcription factor	Homo sapiens	166-169
28944928-11	2017	Furthermore, hydrogen improved the deteriorated hypertrophic responses and inhibited the enhanced autophagic activity mediated by ISO administration in vivo, as indicated by decreasing HW and HW/BW, and suppressing the protein expression levels of Beclin1, Atg7 and LC3B II.	Hydrogen	13-21	autophagy related 7	Mus musculus	257-261
28620699-4	2017	One important PETF electron acceptor found in green microalgae is the biologically and biotechnologically important [FeFe]-hydrogenase HYDA, which catalyses the production of molecular hydrogen (H2) from protons and electrons.	Hydrogen	123-131	uncharacterized protein	Chlamydomonas reinhardtii	14-18
28620699-4	2017	One important PETF electron acceptor found in green microalgae is the biologically and biotechnologically important [FeFe]-hydrogenase HYDA, which catalyses the production of molecular hydrogen (H2) from protons and electrons.	Hydrogen	195-197	uncharacterized protein	Chlamydomonas reinhardtii	14-18
28620699-5	2017	The interaction between PETF and HYDA is of considerable interest, as PETF is the primary electron donor to HYDA and electron supply is one of the main limiting factors for H2 production on a commercial scale.	Hydrogen	173-175	uncharacterized protein	Chlamydomonas reinhardtii	24-28
28620699-5	2017	The interaction between PETF and HYDA is of considerable interest, as PETF is the primary electron donor to HYDA and electron supply is one of the main limiting factors for H2 production on a commercial scale.	Hydrogen	173-175	uncharacterized protein	Chlamydomonas reinhardtii	70-74
28620699-8	2017	Finally, we provide an outlook on new PETF-based biotechnological approaches for improved H2 production efficiencies.	Hydrogen	90-92	uncharacterized protein	Chlamydomonas reinhardtii	38-42
29123019-2	2017	Herein we demonstrate that a photoredox-mediated hydrogen atom transfer protocol can efficiently and selectively install deuterium (D) and tritium (T) at alpha-amino sp3 carbon-hydrogen bonds in a single step, using isotopically labeled water (D2O or T2O) as the source of hydrogen isotope.	Hydrogen	177-185	Sp3 transcription factor	Homo sapiens	166-169
29123019-2	2017	Herein we demonstrate that a photoredox-mediated hydrogen atom transfer protocol can efficiently and selectively install deuterium (D) and tritium (T) at alpha-amino sp3 carbon-hydrogen bonds in a single step, using isotopically labeled water (D2O or T2O) as the source of hydrogen isotope.	Hydrogen	177-185	Sp3 transcription factor	Homo sapiens	166-169
28993160-10	2017	The treatment with BAM8-22 for 1h inhibited chronic morphine-induced increase of MMP-9 and IL-1beta mRNA in DRG but these effects were abolished by MrgC receptor antibody.	Hydrogen	31-33	interleukin 1 beta	Rattus norvegicus	91-99
29225568-13	2017	While the inhibitory action of H2 on GluN1/2B receptors could limit the excessive activation in early age, the enhanced functionality of GluN1/2A receptor in the presence of this gasotransmitter can enlarge synaptic efficacy and promote synaptic plasticity in adults.	Hydrogen	31-33	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	37-42
29166710-16	2017	(2) At PIH 24, the content of HMGB1 and IL-6 in serum and lung tissue of mice in hydrogen group was close to that in sham injury group (with P values above 0.05).	Hydrogen	81-89	interleukin 6	Mus musculus	40-44
29166710-18	2017	The content of HMGB1 and IL-6 in serum and lung tissue of mice in burn+ hydrogen group was significantly lower than that in pure burn group (with P values below 0.001).	Hydrogen	72-80	interleukin 6	Mus musculus	25-29
29022345-3	2017	PXRD, solid-state spectroscopy, EM analysis, and quantum-chemical calculations suggest an outer sphere electron transfer from the COF to the co-catalyst which subsequently follows a monometallic pathway of H2 generation from the CoIII-hydride and/or CoII-hydride species.	Hydrogen	206-208	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	229-234
29022345-3	2017	PXRD, solid-state spectroscopy, EM analysis, and quantum-chemical calculations suggest an outer sphere electron transfer from the COF to the co-catalyst which subsequently follows a monometallic pathway of H2 generation from the CoIII-hydride and/or CoII-hydride species.	Hydrogen	206-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	229-233
29177847-5	2017	The optimized structure and the reduced density gradient (RDG) of the DNP/CL-20 complex confirmed that the main driving forces for cocrystallization were a series of hydrogen bonds and van der Waals forces.	Hydrogen	166-174	epithelial membrane protein 1	Homo sapiens	74-79
29086555-5	2017	The C-terminal residues of short-chain peptides that contain more H-bond acceptor groups could easily form hydrogen bonds with ACE-I and have higher ACE-I inhibitory activity.	Hydrogen	107-115	angiotensin I converting enzyme	Homo sapiens	127-130
29086555-5	2017	The C-terminal residues of short-chain peptides that contain more H-bond acceptor groups could easily form hydrogen bonds with ACE-I and have higher ACE-I inhibitory activity.	Hydrogen	107-115	angiotensin I converting enzyme	Homo sapiens	149-152
29150749-3	2017	Paeoniflorin spontaneously bound to HSA in site I (subdomain IIA), which was primarily driven by hydrophobic forces and hydrogen bonds (DeltaH  = - 9.98 kJ mol-1, DeltaS  = 28.18 J mol-1 K-1).	Hydrogen	120-128	albumin	Homo sapiens	36-39
29150749-7	2017	Meanwhile, the study of molecular docking also indicated that paeoniflorin could bind to the site I of HSA mainly by hydrophobic and hydrogen bond interactions.	Hydrogen	133-141	albumin	Homo sapiens	103-106
28993160-10	2017	The treatment with BAM8-22 for 1h inhibited chronic morphine-induced increase of MMP-9 and IL-1beta mRNA in DRG but these effects were abolished by MrgC receptor antibody.	Hydrogen	31-33	MAS-related G-protein coupled receptor, member C	Rattus norvegicus	148-152
28929553-0	2017	Alkynylation of Csp2 (O)-H Bonds Enabled by Photoredox-Mediated Hydrogen-Atom Transfer.	Hydrogen	64-72	regulator of calcineurin 2	Homo sapiens	16-20
29141431-11	2017	We also revealed this mechanism of the stability as follows: TYR2 and TRP9 side chains cover the hydrogen bonds that form a beta-hairpin structure.	Hydrogen	97-105	amyloid beta precursor protein	Homo sapiens	122-128
29099531-2	2017	After introducing a secondary amide as a hydrogen-bonding crosslinking motif into the side chain of the PPO backbone, the membrane exhibits high mechanical strength and excellent flexibility (101% elongation at break), as well as suppressed water uptake, enhanced thermal stability and good fuel cell performances.	Hydrogen	41-49	protoporphyrinogen oxidase	Homo sapiens	104-107
28929553-2	2017	Reported here is the first photoredox-mediated hydrogen-atom transfer method for the efficient synthesis of ynones, ynamides, and ynoates with high regio- and chemoselectivity by direct functionalization of Csp2 (O)-H bonds.	Hydrogen	47-55	regulator of calcineurin 2	Homo sapiens	207-211
28413992-4	2017	RESULTS: It was found that hydrogen bond interactions play a significant role in the accurate positioning of ligands within the "active site" of BACE1 to permit docking.	Hydrogen	27-35	beta-secretase 1	Homo sapiens	145-150
29041774-2	2017	1H NMR, absorption, fluorescence, and circular dichroism (CD) spectroscopy indicate that, compared with analogous macrocycles that self-associate based on aromatic stacking which is highly sensitive to the electronic nature of the macrocyclic backbones, macrocycles 1-4 all exhibit strong aggregation down to the micromolar (muM) concentrations in nonpolar solvents.	Hydrogen	0-2	latexin	Homo sapiens	325-328
29125121-6	2017	Structure-based mutants targeting the inter-molecular hydrogen bonds and complementary architecture/surfaces in SafDAA-dsc dimers significantly impaired the Saf self-association activity and biofilm formation.	Hydrogen	54-62	FAS antisense RNA 1	Homo sapiens	112-115
28728917-3	2017	We recently demonstrated the important role of tyrosine residues in regulating P-gp ATP hydrolysis via hydrogen bond formations with high affinity modulators.	Hydrogen	103-111	ATP binding cassette subfamily B member 1	Homo sapiens	79-83
29115998-8	2017	More PPI- than H2-antihistamine-treated dogs had gastrin concentrations above URL (P = 0.0205), but not &gt;3x nor &gt;10x the URL.	Hydrogen	15-17	gastrin	Canis lupus familiaris	49-56
28979952-3	2017	The BCNT photocatalysts can catalyse hydrogen evolution from water under visible light illumination.	Hydrogen	37-45	craniofacial development protein 1	Homo sapiens	4-8
29028318-2	2017	In GASright dimers, such as glycophorin A (GpA), BNIP3, and members of the ErbB family, the backbones of the helices are in contact, and they invariably display networks of 4 to 8 weak hydrogen bonds between Calpha-H carbon donors and carbonyl acceptors on opposing helices (Calpha-H   O C hydrogen bonds).	Hydrogen	185-193	glycophorin A (MNS blood group)	Homo sapiens	28-41
29028318-2	2017	In GASright dimers, such as glycophorin A (GpA), BNIP3, and members of the ErbB family, the backbones of the helices are in contact, and they invariably display networks of 4 to 8 weak hydrogen bonds between Calpha-H carbon donors and carbonyl acceptors on opposing helices (Calpha-H   O C hydrogen bonds).	Hydrogen	185-193	glycophorin A (MNS blood group)	Homo sapiens	43-46
29028318-2	2017	In GASright dimers, such as glycophorin A (GpA), BNIP3, and members of the ErbB family, the backbones of the helices are in contact, and they invariably display networks of 4 to 8 weak hydrogen bonds between Calpha-H carbon donors and carbonyl acceptors on opposing helices (Calpha-H   O C hydrogen bonds).	Hydrogen	185-193	BCL2 interacting protein 3	Homo sapiens	49-54
29028318-2	2017	In GASright dimers, such as glycophorin A (GpA), BNIP3, and members of the ErbB family, the backbones of the helices are in contact, and they invariably display networks of 4 to 8 weak hydrogen bonds between Calpha-H carbon donors and carbonyl acceptors on opposing helices (Calpha-H   O C hydrogen bonds).	Hydrogen	290-298	glycophorin A (MNS blood group)	Homo sapiens	28-41
29028318-2	2017	In GASright dimers, such as glycophorin A (GpA), BNIP3, and members of the ErbB family, the backbones of the helices are in contact, and they invariably display networks of 4 to 8 weak hydrogen bonds between Calpha-H carbon donors and carbonyl acceptors on opposing helices (Calpha-H   O C hydrogen bonds).	Hydrogen	290-298	glycophorin A (MNS blood group)	Homo sapiens	43-46
29028318-2	2017	In GASright dimers, such as glycophorin A (GpA), BNIP3, and members of the ErbB family, the backbones of the helices are in contact, and they invariably display networks of 4 to 8 weak hydrogen bonds between Calpha-H carbon donors and carbonyl acceptors on opposing helices (Calpha-H   O C hydrogen bonds).	Hydrogen	290-298	BCL2 interacting protein 3	Homo sapiens	49-54
28485640-3	2017	Hydrogen bonding (H-bonding) plays a key role in plasticization of SPI film.	Hydrogen	0-8	chromogranin A	Homo sapiens	67-70
28817220-6	2017	This difference in binding affinity is largely explained by the higher stability of the hydrogen-bond networks in KLK14/HAI-1 along the simulation trajectory.	Hydrogen	88-96	kallikrein related peptidase 14	Homo sapiens	114-119
28150441-3	2017	ITC analysis indicated that the binding of EuP-82 to fibrinogen in the conditions with or without the activator (Ca2+ ) was an exothermic reaction (dominant negative enthalpy), which tended to be driven by hydrogen bonding and van der Waals interactions.	Hydrogen	206-214	fibrinogen beta chain	Homo sapiens	53-63
29027456-5	2017	By employing first-principles density functional theory calculations, we find that pseudohalogen (CN and OCN) passivated PNRs not only show desired VBM and CBM band edge positions induced by edge electric dipole layer, but also possess intrinsic optoelectronic properties of phosphorene, for both water oxidation and hydrogen reduction in photocatalytic water splitting without using extra energy.	Hydrogen	317-325	bone gamma-carboxyglutamate protein	Homo sapiens	105-108
28388001-5	2017	In addition, water-mediated hydrogen bonds are indicated to be critical in the specific recognition between hAgo2 and the conserved adenine in position 1 of target RNA.	Hydrogen	28-36	argonaute RISC catalytic component 2	Homo sapiens	108-113
28388001-4	2017	Stable direct and water-mediated hydrogen bonds were observed between guide RNA backbone atoms and hAgo2, especially for nucleotides 2-7.	Hydrogen	33-41	argonaute RISC catalytic component 2	Homo sapiens	99-104
28938485-3	2017	Objective: We evaluated whether duodenal abundance of SGLT-1 and GLUT-2 is augmented in subjects with IGT and NGT-1h-high, in comparison with subjects with NGT and 1-hour postload glucose  155 mg/dL (NGT-1h-low).	Hydrogen	114-116	solute carrier family 5 member 1	Homo sapiens	54-60
28938485-3	2017	Objective: We evaluated whether duodenal abundance of SGLT-1 and GLUT-2 is augmented in subjects with IGT and NGT-1h-high, in comparison with subjects with NGT and 1-hour postload glucose  155 mg/dL (NGT-1h-low).	Hydrogen	204-206	solute carrier family 5 member 1	Homo sapiens	54-60
28938485-8	2017	Duodenal SGLT-1 protein and messenger RNA levels were significantly higher in individuals with NGT-1h-high, IGT, or T2DM in comparison with NGT-1h-low subjects.	Hydrogen	99-101	solute carrier family 5 member 1	Homo sapiens	9-15
28938485-8	2017	Duodenal SGLT-1 protein and messenger RNA levels were significantly higher in individuals with NGT-1h-high, IGT, or T2DM in comparison with NGT-1h-low subjects.	Hydrogen	144-146	solute carrier family 5 member 1	Homo sapiens	9-15
29142752-8	2017	The hydrogen-rich water group exhibited no significant differences in liver function before and after treatment, whereas the placebo group exhibited significantly elevated levels of ALT, AST and IBIL.	Hydrogen	4-12	solute carrier family 17 member 5	Homo sapiens	187-190
29104247-5	2017	Molecular dynamics simulation of these complexes lead to the identification of hydrophobic patches, hydrogen-bonds, and salt bridges as three essential forces mediating the interactions between this channel and the toxins, in which four Kv1.2-specific interacting amino acids (D353, Q358, V381, and T383) are identified for the first time.	Hydrogen	100-108	potassium voltage-gated channel subfamily A member 2	Homo sapiens	237-242
29093541-0	2017	High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway.	Hydrogen	19-27	thymoma viral proto-oncogene 1	Mus musculus	115-119
29093541-1	2017	The study investigated the role of Akt1 through the cardioprotection of high-concentration hydrogen (HCH).	Hydrogen	91-99	thymoma viral proto-oncogene 1	Mus musculus	35-39
29093541-7	2017	Several analyses were performed to evaluate the role of the Akt1 in the protective effects of hydrogen.	Hydrogen	94-102	thymoma viral proto-oncogene 1	Mus musculus	60-64
29066782-5	2017	Similar dependency on quenching of ROS due to influential hydrogen bond interaction with glycine residue of Sod1 oxidative stress protein and increased apoptosis were observed in cells.	Hydrogen	58-66	superoxide dismutase 1, soluble	Danio rerio	108-112
29026899-5	2017	The synthesized MST 2D nanocomposites show a 31.9% increase in photocatalytic activity for hydrogen (H2) production relative to the counterpart TiO2(001).	Hydrogen	91-99	mitogen-activated protein kinase kinase kinase 10	Homo sapiens	16-19
29026899-5	2017	The synthesized MST 2D nanocomposites show a 31.9% increase in photocatalytic activity for hydrogen (H2) production relative to the counterpart TiO2(001).	Hydrogen	101-103	mitogen-activated protein kinase kinase kinase 10	Homo sapiens	16-19
29055338-7	2017	In the FTMW spectra, hyperfine interactions were also resolved, arising from the hydrogen or deuterium nuclear spins of I = 1/2 or I = 1, respectively.	Hydrogen	81-89	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	120-136
29058321-7	2017	In contrast, both FT-IR and 1 H NMR analysis suggest that Fc-(l-Phe-d-Oxd)2 -OBn forms a turn conformation stabilized by intramolecular N H   O C hydrogen bonds in solution.	Hydrogen	146-154	AKT interacting protein	Homo sapiens	18-29
28972563-7	2017	Furthermore, NO production and thereafter LR formation induced by auxin and H2 were prevented by 2-4-carboxyphenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO; a specific scavenger of NO) and the inhibitor of nitrate reductase (NR; an important NO synthetic enzyme).	Hydrogen	76-78	nitrate reductase [NADH]	Solanum lycopersicum	218-235
29038209-2	2017	Activation of the sodium-hydrogen exchanger in the heart and vasculature (NHE1 isoform) and the kidneys (NHE3 isoform) may serve as a common mechanism that links both disorders and may underlie their interplay.	Hydrogen	25-33	solute carrier family 9 member A1	Homo sapiens	74-78
29434174-5	2017	Since carbonic anhydrase-2 (CA2) is critically involved in synthesizing hydrogen ions, we investigated its expression in various cells, and found that macrophages highly express CA2.	Hydrogen	72-80	carbonic anhydrase 2	Mus musculus	6-26
29434174-5	2017	Since carbonic anhydrase-2 (CA2) is critically involved in synthesizing hydrogen ions, we investigated its expression in various cells, and found that macrophages highly express CA2.	Hydrogen	72-80	carbonic anhydrase 2	Mus musculus	28-31
29434174-5	2017	Since carbonic anhydrase-2 (CA2) is critically involved in synthesizing hydrogen ions, we investigated its expression in various cells, and found that macrophages highly express CA2.	Hydrogen	72-80	carbonic anhydrase 2	Mus musculus	178-181
28933548-3	2017	The 1736 cm-1 band is adopted as the stretching mode of C O groups in free amorphous fraction (MAF); the 1714 cm-1 band which is relevant to more stable structure, displays more anisotropic in polarized FTIR spectra, and has been confirmed as stretching vibrations of hydrogen-bonded C O groups in the crystalline phase.	Hydrogen	268-276	MAF bZIP transcription factor	Homo sapiens	95-98
28807355-11	2017	Moreover, treatment with H2-rich water decreased the levels of oxidative DNA damage markers such as phosphorylated histone H2AX and 8-hydroxy-2"-deoxyguanosine, and senescence markers such as cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase inhibitor 1, and beta-galactosidase in the CS-exposed mice.	Hydrogen	25-27	cyclin dependent kinase inhibitor 2A	Mus musculus	192-265
28535459-8	2017	A highly specific NIR feature of fatty acids, the elevation of spectral baseline around 6500-4000cm-1, is being explained by the contributions of combination bands resulting from the vibrations of hydrogen-bonded OH groups in the cyclic dimers.	Hydrogen	197-205	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	18-21
29552652-4	2017	The principal component analysis (PCA) of the 1H NMR spectra showed a clear discrimination between those samples within PC1 and PC2.	Hydrogen	46-48	polycystin 2, transient receptor potential cation channel	Homo sapiens	128-131
28956596-2	2017	The ligand L1 and complexes 1 and 2 have been meticulously characterized by elemental analyses and spectral studies (IR, electrospray ionization mass spectrometry, 1H and 13C NMR, UV/vis, fluorescence) and their structures explicitly authenticated by single-crystal X-ray analyses.	Hydrogen	164-166	L1 cell adhesion molecule	Homo sapiens	11-35
28972366-5	2017	In aqueous solutions under simulated solar illumination the modified cathode is photochemically active for hydrogen production, generating the product gas with near-unity Faradaic efficiency at a rate of  10 muL min-1 cm-2 when studied in a three-electrode configuration and polarized at the equilibrium potential of the H+/H2 couple.	Hydrogen	107-115	CD59 molecule (CD59 blood group)	Homo sapiens	212-217
28972366-5	2017	In aqueous solutions under simulated solar illumination the modified cathode is photochemically active for hydrogen production, generating the product gas with near-unity Faradaic efficiency at a rate of  10 muL min-1 cm-2 when studied in a three-electrode configuration and polarized at the equilibrium potential of the H+/H2 couple.	Hydrogen	324-326	CD59 molecule (CD59 blood group)	Homo sapiens	212-217
28798232-7	2017	Here, using a sensitive MS-based analytical method to measure the hydrogen/deuterium exchange of proteins in solution, we analyzed the conformational properties of proNGF and NGF.	Hydrogen	66-74	nerve growth factor	Homo sapiens	164-178
28798232-9	2017	Furthermore, by comparing the hydrogen/deuterium exchange in the mature part of NGF and proNGF, we found that the presence of the pro-part in proNGF causes a structural stabilization of three loop regions in the mature part, possibly through a direct molecular interaction.	Hydrogen	30-38	nerve growth factor	Homo sapiens	80-83
28972563-7	2017	Furthermore, NO production and thereafter LR formation induced by auxin and H2 were prevented by 2-4-carboxyphenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO; a specific scavenger of NO) and the inhibitor of nitrate reductase (NR; an important NO synthetic enzyme).	Hydrogen	76-78	nitrate reductase [NADH]	Solanum lycopersicum	237-239
28972563-9	2017	Genetic evidence suggested that in the presence of H2, Arabidopsis mutants nia2 (in particular) and nia1 (two nitrate reductases (NR)-defective mutants) exhibited defects in lateral root length.	Hydrogen	51-53	nitrate reductase 1	Arabidopsis thaliana	100-104
28972563-10	2017	Together, these results demonstrated that auxin-induced H2 production was associated with lateral root formation, at least partially via a NR-dependent NO synthesis.	Hydrogen	56-58	nitrate reductase [NADH]	Solanum lycopersicum	139-141
28593560-0	2017	1H, 13C and 15N NMR chemical shift assignments of A. thaliana RCD1 RST.	Hydrogen	0-2	WWE protein-protein interaction domain protein family	Arabidopsis thaliana	62-66
28549396-8	2017	After noise exposure, the concentrations of IL-1, IL-6, TNF-alpha, and ICAM-1 in the cochlea of guinea pigs in the hydrogen-saturated saline group were dramatically reduced compared to those in the normal saline group.	Hydrogen	115-123	LOW QUALITY PROTEIN: intercellular adhesion molecule 1	Cavia porcellus	71-77
28260216-4	2017	In the present study, we report backbone 1H, 13C, 15N resonance assignments of acid-denatured human cytochrome c in the aprotic solvent dimethylsulfoxide.	Hydrogen	41-43	cytochrome c, somatic	Homo sapiens	100-112
28593560-5	2017	Here we report the 1H, 15N and 13C chemical shift assignments of the backbone and sidechain atoms for RCD1 (468-589) containing the RST (510-567) domain.	Hydrogen	19-21	WWE protein-protein interaction domain protein family	Arabidopsis thaliana	102-106
28831766-5	2017	In a first step towards the characterization of the Neurofibromin Spred1 interface in solution we assigned backbone and side chain 1H, 13C, and 15N chemical shifts of the Spred1 derived EVH1 domain.	Hydrogen	131-133	neurofibromin 1	Homo sapiens	52-65
28815448-0	2017	1H, 15N and 13C chemical shift assignments of the C-terminal domain of TRADD.	Hydrogen	0-2	TNFRSF1A associated via death domain	Homo sapiens	71-76
28815448-7	2017	Here we report backbone and sidechain 1H, 13C and 15N chemical shift assignments of TRADD DD in pure water as a basis for further structural and functional studies.	Hydrogen	38-40	TNFRSF1A associated via death domain	Homo sapiens	84-89
28815458-5	2017	Here we present nearly complete 1H, 13C, and 15N resonance assignments of (Ca2+)4-CaM bound to a peptide containing the CaMBD sequence in the beta isoform of CaNA (betaCaNA-CaMBDp).	Hydrogen	32-34	calmodulin 1	Homo sapiens	82-85
28918320-11	2017	The Arg82 and Cys126 of CRIP1b are involved in the majority of hydrogen bond interactions with the CB1 receptor and are possible key residues required for interactions between the CB1 receptor and CRIP1b.	Hydrogen	63-71	cannabinoid receptor 1	Homo sapiens	99-102
28727929-6	2017	Due to muscular intracellular acidosis, the intracellular sodium overload in DMD and BMD was also due to sodium influx through the sodium-hydrogen exchanger NHE-1.	Hydrogen	138-146	solute carrier family 9 member A1	Homo sapiens	157-162
28873669-2	2017	The hydrolysate generated with Corolase PP for 1h (SG-C1) had the highest angiotensin converting enzyme (ACE, IC50=0.13+-0.05mgmL-1) and dipeptidyl peptidase IV (DPP-IV, IC50=0.08+-0.01mgmL-1) inhibitory activities, and oxygen radical absorbance capacity (ORAC, 540.94+-9.57mumolTEg-1d.w.).	Hydrogen	47-49	angiotensin I converting enzyme	Rattus norvegicus	74-103
28873669-2	2017	The hydrolysate generated with Corolase PP for 1h (SG-C1) had the highest angiotensin converting enzyme (ACE, IC50=0.13+-0.05mgmL-1) and dipeptidyl peptidase IV (DPP-IV, IC50=0.08+-0.01mgmL-1) inhibitory activities, and oxygen radical absorbance capacity (ORAC, 540.94+-9.57mumolTEg-1d.w.).	Hydrogen	47-49	angiotensin I converting enzyme	Rattus norvegicus	105-108
28369487-2	2017	The T1505, which is conserved among DNMT1s of vertebrates, in the catalytic domain of mouse DNMT1 forms the hydrogen bond with the W1512, which is also conserved among vertebrates and one of the essential residues in recognition of the 5-methylcytosine in hemi-methylated CpGs.	Hydrogen	108-116	DNA methyltransferase (cytosine-5) 1	Mus musculus	36-41
28369487-2	2017	The T1505, which is conserved among DNMT1s of vertebrates, in the catalytic domain of mouse DNMT1 forms the hydrogen bond with the W1512, which is also conserved among vertebrates and one of the essential residues in recognition of the 5-methylcytosine in hemi-methylated CpGs.	Hydrogen	108-116	DNA methyltransferase (cytosine-5) 1	Mus musculus	92-97
28369487-5	2017	Although the mutation lost the hydrogen bond between T1505 and W1512, the overall structure of DNMT1(291-1620)T1505A remained almost identical with that of the wild type.	Hydrogen	31-39	DNA methyltransferase (cytosine-5) 1	Mus musculus	95-100
28950184-0	2017	Regression model for predicting pathogenic properties of SOD1 mutants based on the analysis of conformational stability and conservation of hydrogen bonds.	Hydrogen	140-148	superoxide dismutase 1	Homo sapiens	57-61
28950184-4	2017	This model was built based on an analysis of the stability of hydrogen bonds formed in SOD1 mutant proteins during a molecular dynamics (MD) simulation.	Hydrogen	62-70	superoxide dismutase 1	Homo sapiens	87-91
29173648-2	2017	We hypothesized that angiotensin I-converting enzyme (ACE) inhibitory activities of milk di- and tripeptides could be predicted using 3-dimensional quantitative structure activity relationship methods and that these activities could be explained through evaluation of structural features (hydrogen bond donor/acceptor, hydrophobic, steric, and electrostatic) that are responsible for this bioactivity.	Hydrogen	289-297	angiotensin I converting enzyme	Homo sapiens	54-57
28950184-6	2017	Conformational conservation of hydrogen bonds, being obtained with elastic network (EN) models, allowed us to find eight hydrogen bonds that might affect the pathogenic SOD1 mutants" properties in addition to the bonds that were found via MD in our previous work.	Hydrogen	31-39	superoxide dismutase 1	Homo sapiens	169-173
28950184-6	2017	Conformational conservation of hydrogen bonds, being obtained with elastic network (EN) models, allowed us to find eight hydrogen bonds that might affect the pathogenic SOD1 mutants" properties in addition to the bonds that were found via MD in our previous work.	Hydrogen	121-129	superoxide dismutase 1	Homo sapiens	169-173
28950184-8	2017	SOD1 amino acid residues forming these pathogenic hydrogen bonds are found in zinc-binding and electrostatic loops as well as at zinc-binding sites and are in contact with SOD1 aggregates, which implies that these regions are sensitive to perturbations from pathogenic mutations.	Hydrogen	50-58	superoxide dismutase 1	Homo sapiens	0-4
28950184-8	2017	SOD1 amino acid residues forming these pathogenic hydrogen bonds are found in zinc-binding and electrostatic loops as well as at zinc-binding sites and are in contact with SOD1 aggregates, which implies that these regions are sensitive to perturbations from pathogenic mutations.	Hydrogen	50-58	superoxide dismutase 1	Homo sapiens	172-176
27890389-4	2017	Here, we focus on the involvement of heparanase (HPSE), the sole endo-glucuronidase capable of cleaving of HS, in differentiation of embryonic stem cells into the cells of the neural lineage.	Hydrogen	107-109	heparanase	Mus musculus	37-47
27890389-4	2017	Here, we focus on the involvement of heparanase (HPSE), the sole endo-glucuronidase capable of cleaving of HS, in differentiation of embryonic stem cells into the cells of the neural lineage.	Hydrogen	107-109	heparanase	Mus musculus	49-53
28971603-5	2017	H2 S induced S-sulfhydration of RhoA that was associated with inhibition of RhoA activity.	Hydrogen	0-2	ras homolog family member A	Homo sapiens	32-36
28971603-5	2017	H2 S induced S-sulfhydration of RhoA that was associated with inhibition of RhoA activity.	Hydrogen	0-2	ras homolog family member A	Homo sapiens	76-80
28964007-2	2017	IR spectra and X3LYP/6-31++G(d,p) calculations show that multiple isomers of MEK (MeOH)n are generated in the molecular beam as a result of several hydrogen bonding sites available to the clusters throughout the size range investigated.	Hydrogen	148-156	mitogen-activated protein kinase kinase 7	Homo sapiens	77-80
28728105-8	2017	Molecular docking revealed that the nitrogen atom of imidazopyridines and the oxygen atom of the phenoxypropyl linker were involved in hydrogen bound interactions with Asp228 and Asp32 of BACE1 active site, respectively.	Hydrogen	135-143	beta-secretase 1	Homo sapiens	188-193
28728106-3	2017	And the introduce of connecting amide bonds, enables the target molecules provide sufficient hydrogen bond donors and acceptors to interact with the catalytic site of BACE-1.	Hydrogen	93-101	beta-secretase 1	Homo sapiens	167-173
28963450-7	2017	Differential hydrogen/deuterium exchange analysis demonstrates that SPA70 and SJB7 interact with the hPXR LBD.	Hydrogen	13-21	nuclear receptor subfamily 1 group I member 2	Homo sapiens	101-105
28964007-5	2017	Calculations suggest that the n = 3 cluster isomers adopt structures in which the MEK molecule is inserted into the cyclic MeOH hydrogen bond network.	Hydrogen	128-136	mitogen-activated protein kinase kinase 7	Homo sapiens	82-85
28809482-0	2017	Structural Dynamics of 15-Lipoxygenase-2 via Hydrogen-Deuterium Exchange.	Hydrogen	45-53	arachidonate 15-lipoxygenase	Homo sapiens	23-38
28743498-6	2017	Here, we report that hydrogen-rich medium activated LKB1-AMPK signal pathway without ATP depletion, which in turn induced FoxO1-dependent transcription of manganese superoxide dismutase and catalase in mouse embryonic fibroblasts.	Hydrogen	21-29	serine/threonine kinase 11	Mus musculus	52-56
28842444-1	2017	OBJECTIVE: To assess whether noninvasive proton magnetic resonance spectroscopy (1H-MRS) tissue metabolite measurements at baseline can predict an increase in the rate of beta-amyloid (Abeta) accumulation on serial PET in clinically normal (CN) older adults.	Hydrogen	81-83	amyloid beta precursor protein	Homo sapiens	171-191
28947797-5	2017	Crystallographic analysis demonstrated that the Crwn-THF moiety of GRL-09510 forms strong hydrogen-bond-interactions with HIV-1 protease (PR) active-site amino acids and is bulkier with a larger contact surface, making greater van der Waals contacts with PR than the bis-THF moiety of darunavir.	Hydrogen	90-98	nuclear receptor subfamily 3 group C member 1	Homo sapiens	67-70
28902204-8	2017	2D 1H-15N HSQC NMR chemical shift perturbation mapping was used to chart the binding site of the quercetin analogues in the Bcl-xL that overlapped with the predicted poses generated by both IFD and MD calculations.	Hydrogen	3-5	BCL2 like 1	Homo sapiens	124-130
28743498-6	2017	Here, we report that hydrogen-rich medium activated LKB1-AMPK signal pathway without ATP depletion, which in turn induced FoxO1-dependent transcription of manganese superoxide dismutase and catalase in mouse embryonic fibroblasts.	Hydrogen	21-29	catalase	Mus musculus	190-198
28743498-8	2017	These results suggest that the LKB1-AMPK-FoxO1 signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.	Hydrogen	121-123	serine/threonine kinase 11	Mus musculus	31-35
28743498-8	2017	These results suggest that the LKB1-AMPK-FoxO1 signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.	Hydrogen	158-160	serine/threonine kinase 11	Mus musculus	31-35
28890958-3	2017	The employment of PPh3 leads to the formation of 2-furanones 2 through a migration of an alkoxyl group, and 2-furanones 3 were generated through a migration of hydrogen in the presence of Xantphos, affording a divergent approach to 2-furanones bearing multiple functional groups.	Hydrogen	160-168	caveolin 1	Homo sapiens	18-22
28815973-8	2017	A comparison of the reaction kinetics on GaPd2 with experimental results obtained for GaPd reveals different orders of reaction of H2 and C2 H2 on the two compounds.	Hydrogen	131-133	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	41-45
28815973-8	2017	A comparison of the reaction kinetics on GaPd2 with experimental results obtained for GaPd reveals different orders of reaction of H2 and C2 H2 on the two compounds.	Hydrogen	141-143	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	41-45
28836757-14	2017	We found that only [H-Fe4N(CO)12]- and its derivative [H-Fe4N(CO)11(PPh3)]- have hydricities modest enough to avoid H2 production but strong enough to make formate.	Hydrogen	116-118	caveolin 1	Homo sapiens	68-72
28731695-9	2017	The study shows that, compared to the inactive 11-cis-retinal case, trans-retinal rhodopsin is able to undergo PSB deprotonation due to a change in the conformation of the retinal and a consequent alteration in the hydrogen-bond (HB) network in which PSB and the counterion Glu113 are embedded.	Hydrogen	215-223	rhodopsin	Homo sapiens	82-91
29057059-3	2017	The drastic profile improvement of the new series has been rationalized by an additional hydrogen bonding with the nonconserved Q69 residue in the active site of hCA VII (absent in the other three isoforms studied), which also results in a favorable accommodation of the inhibitor"s lipophilic periphery in the nearby hydrophobic pocket.	Hydrogen	89-97	carbonic anhydrase 7	Homo sapiens	162-169
28742962-0	2017	Characterization of Intramolecular Interactions of Cytochrome c Using Hydrogen-Deuterium Exchange-Trapped Ion Mobility Spectrometry-Mass Spectrometry and Molecular Dynamics.	Hydrogen	70-78	cytochrome c, somatic	Homo sapiens	51-63
28783321-5	2017	1H-transferred 13C INEPT spectra indicate that the interfibrillar HG backbones are more aggregated whereas the RG-I side chains are more dispersed in PGX1AT cell walls than in pgx1-2 walls.	Hydrogen	0-2	Pectin lyase-like superfamily protein	Arabidopsis thaliana	176-180
28771327-2	2017	We present here, for the first time, sparse Au NPs self-supported on etched Ti (nanocarved Ti substrate self-supported with TiH2) as promising catalysts for the electrochemical generation of hydrogen (H2) in KOH solutions.	Hydrogen	191-199	RuvB like AAA ATPase 2	Homo sapiens	76-78
28771327-2	2017	We present here, for the first time, sparse Au NPs self-supported on etched Ti (nanocarved Ti substrate self-supported with TiH2) as promising catalysts for the electrochemical generation of hydrogen (H2) in KOH solutions.	Hydrogen	191-199	RuvB like AAA ATPase 2	Homo sapiens	91-93
28771327-2	2017	We present here, for the first time, sparse Au NPs self-supported on etched Ti (nanocarved Ti substrate self-supported with TiH2) as promising catalysts for the electrochemical generation of hydrogen (H2) in KOH solutions.	Hydrogen	191-199	RuvB like AAA ATPase 2	Homo sapiens	124-128
28771327-2	2017	We present here, for the first time, sparse Au NPs self-supported on etched Ti (nanocarved Ti substrate self-supported with TiH2) as promising catalysts for the electrochemical generation of hydrogen (H2) in KOH solutions.	Hydrogen	126-128	RuvB like AAA ATPase 2	Homo sapiens	76-78
28771327-2	2017	We present here, for the first time, sparse Au NPs self-supported on etched Ti (nanocarved Ti substrate self-supported with TiH2) as promising catalysts for the electrochemical generation of hydrogen (H2) in KOH solutions.	Hydrogen	126-128	RuvB like AAA ATPase 2	Homo sapiens	91-93
28835957-3	2017	This work was underpinned by detailed mechanistic studies examining the hydrogenation of 1 : 1 mixtures of 2 and bipy in CH2Cl2, which proceeds with disparate rates to afford [M(bipy)H2(PPh3)2][BArF4] (M = Rh, 4a[BArF4], t = 18 h @ 50  C; Ir, 4b[BArF4], t &lt; 5 min @ RT) in CH2Cl2 (1 atm H2).	Hydrogen	122-124	caveolin 1	Homo sapiens	186-190
28812082-6	2017	This ion "heating" is demonstrated by analyzing the observed isotope distributions (sensitive to the aforementioned hydrogen rearrangements) of ETD fragments of ubiquitin and substance P.	Hydrogen	116-124	tachykinin precursor 1	Homo sapiens	175-186
28742962-1	2017	Globular proteins, such as cytochrome c (cyt c), display an organized native conformation, maintained by a hydrogen bond interaction network.	Hydrogen	107-115	cytochrome c, somatic	Homo sapiens	27-39
28742962-1	2017	Globular proteins, such as cytochrome c (cyt c), display an organized native conformation, maintained by a hydrogen bond interaction network.	Hydrogen	107-115	cytochrome c, somatic	Homo sapiens	41-46
28742962-2	2017	In the present work, the structural interrogation of kinetically trapped intermediates of cyt c was performed by correlating the ion-neutral collision cross section (CCS) and charge state with the starting solution conditions and time after desolvation using collision induced activation (CIA), time-resolved hydrogen/deuterium back exchange (HDX) and trapped ion mobility spectrometry-mass spectrometry (TIMS-MS).	Hydrogen	309-317	cytochrome c, somatic	Homo sapiens	90-95
28869548-5	2017	Docking analysis results for complexes with BACE1 indicated that SER10 and THR232 residues of BACE1 hydrogen bonded with two oxygen atoms of tangeretin, while three additional BACE1 residues (ALA157, VAL336 and THR232) interacted with three oxygen atoms of nobiletin.	Hydrogen	100-108	beta-secretase 1	Homo sapiens	44-49
29057046-3	2017	The new analogues 4d, 4e, and 7b bearing added hydrophilic substituents, so as to establish additional hydrogen bonding on the rim of the HDAC6 catalytic pocket, exhibit improved potency against HDAC6 and retain selectivity over HDAC1.	Hydrogen	103-111	histone deacetylase 6	Homo sapiens	138-143
28869548-5	2017	Docking analysis results for complexes with BACE1 indicated that SER10 and THR232 residues of BACE1 hydrogen bonded with two oxygen atoms of tangeretin, while three additional BACE1 residues (ALA157, VAL336 and THR232) interacted with three oxygen atoms of nobiletin.	Hydrogen	100-108	beta-secretase 1	Homo sapiens	94-99
28869548-5	2017	Docking analysis results for complexes with BACE1 indicated that SER10 and THR232 residues of BACE1 hydrogen bonded with two oxygen atoms of tangeretin, while three additional BACE1 residues (ALA157, VAL336 and THR232) interacted with three oxygen atoms of nobiletin.	Hydrogen	100-108	beta-secretase 1	Homo sapiens	94-99
28757100-3	2017	Among them, the inhibitory activity of compound 1h to COX-2 was IC50=0.049mumol/L and SI &gt;1000.	Hydrogen	48-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
28915088-7	2017	Biological synthesis, if occurring, could produce a maximum of 90 muM concentrations of amino acids based on a methanogenic ecosystem consuming H2 and CO2.	Hydrogen	144-146	latexin	Homo sapiens	66-69
28743508-9	2017	Good ATX inhibitory activity of 21 was attributed to the hydrogen bonding interactions with Asn230, Trp275 and active site water molecules; electrostatic interaction with catalytic zinc ion and hydrophobic interactions with amino acids of the hydrophobic pocket.	Hydrogen	57-65	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	5-8
28795606-6	2017	ELISA assay showed hydrogen-rich saline lowered the levels of pro-inflammatory cytokines (IL-8 and IL-6) and anti-inflammatory cytokine IL-10 in bronchoalveolar lavage fluid and serum of chronic obstructive pulmonary disease rats.	Hydrogen	19-27	interleukin 6	Rattus norvegicus	99-103
28377238-7	2017	Results of MD simulations indicated that GL-BSA complex forms mainly on the basis of hydrogen bonds, while, GA-BSA complex forms on the basis of hydrophobic interactions.	Hydrogen	85-93	albumin	Homo sapiens	44-47
28377238-8	2017	Also, water molecules can bridge between the ligand and protein by hydrogen bonds, which are stable during the entire simulation and play an important role in stabilization of the GL/GA-BSA complexes.	Hydrogen	67-75	albumin	Homo sapiens	186-189
28732681-9	2017	In comparison, 25(OH)D correlated less well with DBP (1h time lag, r=0.07, P=0.12).	Hydrogen	54-56	D-box binding PAR bZIP transcription factor	Homo sapiens	49-52
27632558-3	2017	The fluorescence spectroscopy results demonstrated that the binding of Fe-NP with Cyt c is mediated by hydrogen bonds and van der Waals interactions.	Hydrogen	103-111	cytochrome c, somatic	Homo sapiens	82-87
28673858-7	2017	The controlled release of ESP was attributed to the interactions among ESP-counter ion-PSA by hydrogen bonding, and counter ion enhanced the interaction between ESP and PSA molecule, which acted as a "bridge" between them.	Hydrogen	94-102	aminopeptidase puromycin sensitive	Rattus norvegicus	87-90
28670772-6	2017	Accordingly, this study proposes a regulatory pathway for endogenous H2 S generation, indicating that plants respond to Cr6+ stress by adjusting the binding affinity of TGA3 to the LCD promoter, which increases LCD expression and promotes H2 S production.	Hydrogen	69-71	transcription factor TGA3	Arabidopsis thaliana	169-173
28234792-0	2017	Hydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release.	Hydrogen	0-8	heme oxygenase 1	Mus musculus	121-125
28234792-9	2017	The results showed that therapy with 2% H2 increased the survival rate, alleviated the injuries caused by oxidative stress and inflammation, reduced HMGB1 levels but increased HO-1 levels in WT septic mice, but not in Nrf2-KO mice.	Hydrogen	40-42	heme oxygenase 1	Mus musculus	176-180
28234792-10	2017	These data demonstrate that 2% H2 inhalation may be a promising therapeutic strategy for intestinal injuries caused by severe sepsis through the regulation of HO-1 and HMGB1 release.	Hydrogen	31-33	heme oxygenase 1	Mus musculus	159-163
28234792-11	2017	In addition, Nrf2 plays a key role in the protective effects of H2 against intestinal damage in this disease.	Hydrogen	64-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
28795705-1	2017	Mg(BH4)2 is a promising solid-state hydrogen storage material, releasing 14.9 wt% hydrogen upon conversion to MgB2.	Hydrogen	36-44	secretoglobin family 2A member 1	Homo sapiens	110-114
28795705-3	2017	Here, we present a joint experimental-theoretical study that elucidates the key atomistic mechanisms associated with the initial stages of hydrogen uptake within MgB2.	Hydrogen	139-147	secretoglobin family 2A member 1	Homo sapiens	162-166
28795705-6	2017	The results from the kinetic model suggest that initial hydrogenation takes place via a multi-step process: molecular H2 dissociation, likely at Mg-terminated MgB2 surfaces, is followed by migration of atomic hydrogen to defective boron sites, where the formation of stable B-H bonds ultimately leads to the direct creation of Mg(BH4)2 complexes without persistent BxHy intermediates.	Hydrogen	118-120	secretoglobin family 2A member 1	Homo sapiens	159-163
28795705-6	2017	The results from the kinetic model suggest that initial hydrogenation takes place via a multi-step process: molecular H2 dissociation, likely at Mg-terminated MgB2 surfaces, is followed by migration of atomic hydrogen to defective boron sites, where the formation of stable B-H bonds ultimately leads to the direct creation of Mg(BH4)2 complexes without persistent BxHy intermediates.	Hydrogen	56-64	secretoglobin family 2A member 1	Homo sapiens	159-163
28605076-1	2017	Three new closely related CoII YIII complexes of general formula [Co(mu-L)(mu-X)Y(NO3 )2 ] (X- =NO3- 1, benzoate 2, or 9-anthracenecarboxylato 3) have been prepared with the compartmental ligand N,N",N""-trimethyl-N,N""-bis(2-hydroxy-3-methoxy-5-methylbenzyl)diethylenetriamine (H2 L).	Hydrogen	279-281	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
28852144-6	2017	ELISA analyses showed that inhalation of hydrogen-oxygen mixed gas blocked CMS-induced increase in the serum levels of corticosterone, adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor-alpha in mice exposed to chronic mild stress.	Hydrogen	41-49	interleukin 6	Mus musculus	164-210
28525844-5	2017	The binding mode shows that compound 11 interacts with the binding pocket of ERRalpha through hydrogen interactions with the residue Gly397 and hydrophobic interactions with the hydrophobic residues.	Hydrogen	94-102	estrogen related receptor alpha	Homo sapiens	77-85
28631847-1	2017	Dipyrrolyldiketone BF2 complexes with amide units at pyrrole alpha-positions were synthesized in modest yields and showed extremely high anion-binding affinities because of multiple hydrogen-bonding interactions.	Hydrogen	182-190	forkhead box G1	Homo sapiens	19-22
28766603-2	2017	This highly reproducible and simple method via H2 reduction produces well dispersed, small nanoparticles (NPs), which were characterized by the state-of-the-art techniques, such as TEM, HRTEM, WAXS and ATR FT-IR spectroscopy.	Hydrogen	47-49	ATR serine/threonine kinase	Homo sapiens	202-205
28696098-0	2017	Enhanced Binding Affinity via Destabilization of the Unbound State: A Millisecond Hydrogen-Deuterium Exchange Study of the Interaction between p53 and a Pleckstrin Homology Domain.	Hydrogen	82-90	tumor protein p53	Homo sapiens	143-146
28328213-0	2017	Reversible Coordination of Boron-, Aluminum-, Zinc-, Magnesium-, and Calcium-Hydrogen Bonds to Bent {CuL2} Fragments: Heavy sigma Complexes of the Lightest Coinage Metal.	Hydrogen	77-85	cullin 2	Homo sapiens	101-105
28777545-14	2017	H2 dissociatively chemisorbs at a Pt surface to form Pt-H, but in contrast to Pd, it stays on the Pt surface.	Hydrogen	0-2	parathyroid hormone	Homo sapiens	53-57
28655765-4	2017	Here, using crystallographic and biochemical analyses, we show that the beta4 extracellular domains directly interact with each other in a parallel manner that involves an intermolecular disulfide bond between the unpaired Cys residues (Cys58) in the loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of the N-terminal segments (Ser30-Val35).	Hydrogen	318-326	adaptor related protein complex 4 subunit beta 1	Homo sapiens	72-77
28621377-5	2017	Furthermore, the solution dynamics of Co(ii) complexes are highlighted with the help of paramagnetic 1H-NMR spectroscopy.	Hydrogen	101-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-44
28714505-9	2017	Docking studies indicated that DpdtC bound to a flexible region of catalase, involving hydrogen bonds and salt bond; this was consistent with thermodynamic results from spectral investigations.	Hydrogen	87-95	catalase	Homo sapiens	67-75
28692798-3	2017	Here we employed equilibrium hydrogen/deuterium fractionation factors to measure backbone hydrogen bond strengths in the TM helix of the amyloid precursor protein (APP).	Hydrogen	29-37	amyloid beta precursor protein	Homo sapiens	137-162
28692798-3	2017	Here we employed equilibrium hydrogen/deuterium fractionation factors to measure backbone hydrogen bond strengths in the TM helix of the amyloid precursor protein (APP).	Hydrogen	90-98	amyloid beta precursor protein	Homo sapiens	137-162
28614179-8	2017	Furthermore, H2 treatment significantly ameliorated the increase in serum and hippocampal proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and high-mobility group protein 1 in surgery-challenged animals.	Hydrogen	13-15	tumor necrosis factor	Rattus norvegicus	116-143
28614179-8	2017	Furthermore, H2 treatment significantly ameliorated the increase in serum and hippocampal proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and high-mobility group protein 1 in surgery-challenged animals.	Hydrogen	13-15	interleukin 1 beta	Rattus norvegicus	145-162
28614179-8	2017	Furthermore, H2 treatment significantly ameliorated the increase in serum and hippocampal proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and high-mobility group protein 1 in surgery-challenged animals.	Hydrogen	13-15	interleukin 6	Rattus norvegicus	164-177
28646302-9	2017	Interleukin (IL)-1beta, IL-6, IL-8 and IL-10 levels in the serum all increased POST-1h (P &gt; 0.05) but returned to pre-exercise levels POST-1d.	Hydrogen	84-86	interleukin 1 beta	Homo sapiens	0-22
28798314-0	2017	Oxidative coupling of sp 2 and sp 3 carbon-hydrogen bonds to construct dihydrobenzofurans.	Hydrogen	43-51	Sp3 transcription factor	Homo sapiens	31-35
28254344-2	2017	The aim of the study was to explore and understand the influence of applied voltage and influent COD concentration on concurrent H2 production and P recovery in MEC.	Hydrogen	129-131	C-C motif chemokine ligand 28	Homo sapiens	161-164
28646302-9	2017	Interleukin (IL)-1beta, IL-6, IL-8 and IL-10 levels in the serum all increased POST-1h (P &gt; 0.05) but returned to pre-exercise levels POST-1d.	Hydrogen	84-86	interleukin 6	Homo sapiens	24-28
28646302-9	2017	Interleukin (IL)-1beta, IL-6, IL-8 and IL-10 levels in the serum all increased POST-1h (P &gt; 0.05) but returned to pre-exercise levels POST-1d.	Hydrogen	84-86	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
27453381-8	2017	However, NF1 have additionally formed a single hydrogen bond with LYS 413.	Hydrogen	47-55	neurofibromin 1	Homo sapiens	9-12
28549582-6	2017	cR8 forms extensive hydrogen bonding with SPSB2 residues, but loss of an intramolecular hydrogen bond that is present in SPSB2-bound iNOS peptide may destabilize the bound conformation of cR8 and lead to a gentle reduction in SPSB2 binding affinity.	Hydrogen	88-96	nitric oxide synthase 2	Homo sapiens	133-137
28343137-3	2017	The synthesized compounds were evaluated for their potential as a glycomimetic acceptor of lysozyme using different biophysical and computational methods such as 1H NMR, STD NMR, DOSY and Molecular docking.	Hydrogen	162-164	lysozyme	Homo sapiens	91-99
28607147-5	2017	1H NMR-based metabolomics analysis revealed that the Per2 depletion causes significant changes in metabolic profiles of erythrocytes, including increased lactate and decreased ATP levels compared with wild-type mice.	Hydrogen	0-2	period circadian clock 2	Mus musculus	53-57
28515318-6	2017	Hydrogen-deuterium exchange MS revealed that membrane-resident HRas, but not soluble HRas, enhances conformational changes associated with membrane binding by increasing membrane recruitment of both p110alpha and p110delta.	Hydrogen	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	199-208
28510292-4	2017	As a result, the optimized Cd/CdO/CdS heterojunction photoanode showed outstanding and long-term photoelectrochemical activity for water splitting, with a current density of 3.52 mA cm-2 , or a benchmark specific hydrogen production rate of 1.65 mumol cm-2  min-1 at -0.3 V versus Ag/AgCl, by using the environmental pollutants of sulfide and sulfite as sacrificial agents.	Hydrogen	213-221	cell adhesion associated, oncogene regulated	Homo sapiens	30-33
30970989-3	2017	The hydrogen bonds and pi-pi interactions between graphene and the SPI molecules were showed with the attenuated total reflectance Fourier transform infrared (ATR FT-IR) spectroscopy, and X-ray diffraction (XRD).	Hydrogen	4-12	chromogranin A	Homo sapiens	67-70
28654284-3	2017	This structure is designed to mitigate the rapid decomposition of the radical via intramolecular 1,5-hydrogen atom transfer (1,5-HAT) that was observed in its constitutional isomer 1-H with four mPEG-3 groups in the vicinity of the nitrogen-centered radical (1- and 8-positions of TTBC).	Hydrogen	101-109	paternally expressed 3	Mus musculus	195-201
28670901-3	2017	Complete conjugation across the backbone can be achieved through complexation with BF2, as observed by 1H NMR analysis and UV/vis spectroscopy.	Hydrogen	103-105	forkhead box G1	Homo sapiens	83-86
28586217-4	2017	Experimental investigations and theoretical calculations confirm that the remarkable activity of the obtained material results from the unique 3D hierarchical architecture and interface reconstruction between Ni3Se2 and Co9S8 through Ni-S bonding, which leads to charge redistribution and thus lowers the energy barrier of hydrogen desorption in the water splitting process.	Hydrogen	323-331	solute carrier family 5 member 5	Homo sapiens	234-238
28533135-4	2017	Using surface plasmon resonance, analytical rheology, and hydrogen-deuterium exchange mass spectrometry (HXMS), we decipher mechanisms of A1-GPIbalpha-mediated platelet adhesion and resolve dynamic secondary structure elements that regulate the binding pathway.	Hydrogen	58-66	BCL2 related protein A1	Homo sapiens	138-150
28411455-7	2017	Docking analysis indicated that besides the typical interactions of most selective c-Met inhibitors, the intramolecular halogen bond and additional hydrogen bond interactions with kinase are beneficial to the binding.	Hydrogen	148-156	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	83-88
28728239-0	2017	[Effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells of allergic rhinitis guinea pigs model].	Hydrogen	11-19	forkhead box protein P3	Cavia porcellus	54-59
28728239-1	2017	Objective: To explore the effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells in a guinea pig model of allergic rhinitis (AR) and investigate the underling anti-inflammatory mechanism.	Hydrogen	36-44	forkhead box protein P3	Cavia porcellus	79-84
28621947-1	2017	Mixed self-assembly of ligands 1, 2, 1,6-hexanediamine (HDA), and Pd(NO3)2 afforded Fujita-type metal organic polyhedron MOP1 (diameter   8.2 nm), which is covalently functionalized with an average of 18 cucurbit[7]uril (CB[7]) units, as evidenced by 1H NMR, diffusion-ordered spectroscopy NMR, and transmission electron microscopy measurements.	Hydrogen	251-253	MOP-1	Homo sapiens	121-125
28436679-8	2017	Three-dimensional molecular conformation showed reduced hydrogen bond between Asp254 and mutant Thr257, indicating the weakened stability and binding ability of CITED2.	Hydrogen	56-64	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	Homo sapiens	161-167
28639641-5	2017	Our results highlight the crucial role of lysine residues for formation of the triple helical structure of Adpn, possibly due to the extension of both intra- and interstrand hydrogen bonding networks.	Hydrogen	174-182	adiponectin, C1Q and collagen domain containing	Homo sapiens	107-111
28488285-5	2017	This [CoII (CoII -H- )] species then accepts another H+ to release H2 .	Hydrogen	67-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-10
28488285-5	2017	This [CoII (CoII -H- )] species then accepts another H+ to release H2 .	Hydrogen	67-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-16
28773097-5	2017	A maximum hydrogen generation rate of 35 mL min-1 was achieved when Cu sputtering power and time were 200 W and 60 min and while acid concentration and dealloying time were 18 M and 90 min, respectively.	Hydrogen	10-18	CD59 molecule (CD59 blood group)	Homo sapiens	44-49
28438657-3	2017	Molecular dynamics simulations of HSA in the sub-microsecond timescale show that while sulfur exposure to solvent is limited and fluctuating in the thiol form, it increases in the thiolate, stabilized by a persistent hydrogen-bond (HB) network involving Tyr84 and bridging waters to Asp38 and Gln33 backbone.	Hydrogen	217-225	albumin	Homo sapiens	34-37
28900091-2	2017	In this work, we have applied the method of the deuterium/hydrogen exchange in combination with ultra-high-resolution mass spectrometry to study conformational changes in (1-16) beta-amyloid peptide induced by binding of zinc(II) atoms.	Hydrogen	58-66	amyloid beta precursor protein	Homo sapiens	178-198
28120533-6	2017	DR4 and DR5 receptors were thus immobilized on a chromatographic support, and the binding of the 2 ligands TRAIL and NPT to DR4 and DR5 was studied in the temperature range 30 C to 50 C. Negative enthalpy (DeltaH) values indicated that van der Waals interactions and hydrogen bonding are engaged favorably at the ligand-receptor interface.	Hydrogen	267-275	TNF superfamily member 10	Homo sapiens	107-112
28482570-6	2017	The molecular docking studies of the heteroleptic silver(I) complexes with EGFR/VEGFR2 kinase receptors show hydrophobic, pi-pi, sigma-pi and hydrogen bonding interactions.	Hydrogen	142-150	epidermal growth factor receptor	Homo sapiens	75-79
28558143-7	2017	Using hydrogen-deuterium exchange with mass spectrometry, we determined that diverse disease-associated SOD1 mutations cause a common structural defect - perturbation of the SOD1 electrostatic loop.	Hydrogen	6-14	superoxide dismutase 1	Homo sapiens	104-108
28558143-7	2017	Using hydrogen-deuterium exchange with mass spectrometry, we determined that diverse disease-associated SOD1 mutations cause a common structural defect - perturbation of the SOD1 electrostatic loop.	Hydrogen	6-14	superoxide dismutase 1	Homo sapiens	174-178
28342783-8	2017	The better stability of RLPO -films was attributed to PPZ being molecularly dispersed and also because of strong drug-polymer interactions in the films, while increasing storage temperatures weakened the hydrogen bonding interactions in the EPO -films.	Hydrogen	204-212	erythropoietin	Homo sapiens	241-244
28598606-4	2017	Crystal structures of dimeric and hexameric insulin preparations suggest that a hydrogen bond between the hydroxyl group of Hzp and a backbone amide carbonyl positioned across the dimer interface may be responsible for the altered behavior.	Hydrogen	80-88	insulin	Homo sapiens	44-51
28794951-3	2017	Among these porous polymers, HCP-4 had the highest H2 uptake of 9.29 mmol g-1 at 77 K and 0.1 MPa and the highest C2H2 uptake of 6.69 mmol g-1 at 273 K and 0.1 MPa, whereas HCP-3 showed the best CO2 uptake of 4.42 mmol g-1 at 273 K and 0.1 MPa.	Hydrogen	51-53	CYCS pseudogene 4	Homo sapiens	29-34
28629119-7	2017	Molecular docking analyses were conducted for potential AChE and BChE inhibitors, and the results demonstrated that the peripheral anionic sites of target proteins were predominant binding sites for these compounds through hydrogen bonds and halogen interactions instead of hydrophobic interactions in the catalytic active site.	Hydrogen	223-231	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-60
28490576-2	2017	Moreover, because neutrophil activity is highly dependent on intracellular pH (pHi), we propose a direct mechanistic link between complement activation and neutrophil pHi In this article, we demonstrate that in vitro exposure of human neutrophils to C5a significantly increased pHi by selective activation of the sodium/hydrogen exchanger.	Hydrogen	320-328	complement C5a receptor 1	Homo sapiens	250-253
33429585-4	2017	In this work, we developed a hybrid bioink composed of a hydrogen bonding monomer (N-acryloyl glycinamide) (NAGA) and nanoclay.	Hydrogen	57-65	alpha-N-acetylgalactosaminidase	Homo sapiens	108-112
28781408-12	2017	In contrast, protonation of [1(mu-H)]0 yields 0.5 equiv of H2 by a proposed protonation-induced electron transfer process.	Hydrogen	59-61	familial progressive hyperpigmentation 1	Homo sapiens	31-35
28449325-0	2017	Electrosynthesis of Bifunctional WS3-x /Reduced Graphene Oxide Hybrid for Hydrogen Evolution Reaction and Oxygen Reduction Reaction Electrocatalysis.	Hydrogen	74-82	dynactin subunit 6	Homo sapiens	33-36
28620198-6	2017	Molecular hydrogen (H2) was found to be more effectively protected H2O2-induced IP3R1 dysfunction by reducing disulfide bonds, rather than quenching ROS.	Hydrogen	10-18	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	80-85
28620198-6	2017	Molecular hydrogen (H2) was found to be more effectively protected H2O2-induced IP3R1 dysfunction by reducing disulfide bonds, rather than quenching ROS.	Hydrogen	20-22	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	80-85
28346703-2	2017	The presence of a hydrogen bond donor at the C-3 position of 2,5-anhydro-d-mannitol derivatives is essential for effective binding to GLUT5 and transport into tumor cells.	Hydrogen	18-26	solute carrier family 2 member 5	Homo sapiens	134-139
28259079-6	2017	Herein, two special chemical reactions were proposed as the dominant mechanisms, i.e., hydrogen bonding between the carboxyl group of the host Met and the hydroxyl group of As(III) or As(V), and the formation of a chelate ring between the guest As(III) and the S, N bidentate ligands of the intercalated Met in the LDHs.	Hydrogen	87-95	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	184-189
28363167-4	2017	A further molecule-docking discloses the existence of three hydrogen-bonds in CyPD-emodin complex.	Hydrogen	60-68	peptidylprolyl isomerase F	Homo sapiens	78-82
28150185-10	2017	Similar findings regarding copeptin and 1h-hs-cTnT/I changes were obtained for mild hs-cTnT elevations.	Hydrogen	40-42	troponin T2, cardiac type	Homo sapiens	46-50
28594916-7	2017	Based on these results, an hTGR5-nomilin binding model was constructed using in silico docking simulation, demonstrating that four hydrophilic hydrogen-bonding interactions occur between nomilin and hTGR5.	Hydrogen	143-151	G protein-coupled bile acid receptor 1	Homo sapiens	27-32
28594916-7	2017	Based on these results, an hTGR5-nomilin binding model was constructed using in silico docking simulation, demonstrating that four hydrophilic hydrogen-bonding interactions occur between nomilin and hTGR5.	Hydrogen	143-151	G protein-coupled bile acid receptor 1	Homo sapiens	199-204
27782307-4	2017	In the present study relative free energies of binding are estimated for one or two non-hydrogen atom changes in compounds targeting the proteins ACK1 and p38 MAP kinase using three methods.	Hydrogen	88-96	mitogen-activated protein kinase 14	Homo sapiens	155-158
28495556-1	2017	Pursuing the strategy of developing potent AChE inhibitors, we attempted to carry out the N1-substitution of 2,3-dihydroquinazolin-4(1H)-one core.	Hydrogen	133-135	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-47
28195409-1	2017	Isolable dialkylsilylene 5 reacts with dihydrogen in the presence of a small amount of a conventional Lewis acid (BPh3 , BEt3 ) or a base (PPh3 , PEt3 , NPh3 , NEt3 ) at low temperatures in a hydrocarbon solvent, giving the corresponding dihydrosilane 10 in high yields.	Hydrogen	39-49	caveolin 1	Homo sapiens	139-143
28150185-10	2017	Similar findings regarding copeptin and 1h-hs-cTnT/I changes were obtained for mild hs-cTnT elevations.	Hydrogen	40-42	troponin T2, cardiac type	Homo sapiens	87-91
28675985-0	2017	Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1.	Hydrogen	0-8	sirtuin 1	Rattus norvegicus	117-122
28344076-8	2017	In addition, docking simulations indicated that the pi-pi interaction between CYP3A4 and GC, and hydrogen-bond interaction between CYP3A5 and GG might result in their different inhibitory actions.	Hydrogen	97-105	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	131-137
28596808-5	2017	It has been suggested that saturated hydrogen saline may downregulate expression of nuclear factor (NF)-kappaB, leading to a decrease in Beclin-1 transcription and inhibition of autophagy.	Hydrogen	37-45	nuclear factor kappa B subunit 1	Homo sapiens	84-110
28675985-8	2017	We further investigated the role of Sirtuin 1 (SIRT1) in HALI, which contributes to cellular regulation including ERS, by examining its expression after hydrogen treatment with SIRT1 inhibitor.	Hydrogen	153-161	sirtuin 1	Rattus norvegicus	36-45
28675985-9	2017	Hydrogen could significantly reduce HALI by reducing lung edema and apoptosis, inhibiting the elevating of ERS and increased SIRT1 expression.	Hydrogen	0-8	sirtuin 1	Rattus norvegicus	125-130
28675985-10	2017	By inhibition of SIRT1 expression, the effect of hydrogen on prevention of HALI is significantly weakened, the inhibition of the ERS was also reversed.	Hydrogen	49-57	sirtuin 1	Rattus norvegicus	17-22
28675985-8	2017	We further investigated the role of Sirtuin 1 (SIRT1) in HALI, which contributes to cellular regulation including ERS, by examining its expression after hydrogen treatment with SIRT1 inhibitor.	Hydrogen	153-161	sirtuin 1	Rattus norvegicus	47-52
28675985-11	2017	Our findings indicate that hydrogen could reduce HALI related ERS and the mechanism of hydrogen may be associated with upregulation of SIRT1, this study reveals the molecular mechanisms underlying the protective effect of hydrogen, which provides a new theoretical basis for clinical application of hydrogen.	Hydrogen	27-35	sirtuin 1	Rattus norvegicus	135-140
27410776-10	2017	Isoalloxazine derivatives were docked against human AChE, which revealed critical residues implicated in hydrogen bonds as well as hydrophobic interactions.	Hydrogen	105-113	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-56
28675985-11	2017	Our findings indicate that hydrogen could reduce HALI related ERS and the mechanism of hydrogen may be associated with upregulation of SIRT1, this study reveals the molecular mechanisms underlying the protective effect of hydrogen, which provides a new theoretical basis for clinical application of hydrogen.	Hydrogen	87-95	sirtuin 1	Rattus norvegicus	135-140
28675985-11	2017	Our findings indicate that hydrogen could reduce HALI related ERS and the mechanism of hydrogen may be associated with upregulation of SIRT1, this study reveals the molecular mechanisms underlying the protective effect of hydrogen, which provides a new theoretical basis for clinical application of hydrogen.	Hydrogen	87-95	sirtuin 1	Rattus norvegicus	135-140
28675985-11	2017	Our findings indicate that hydrogen could reduce HALI related ERS and the mechanism of hydrogen may be associated with upregulation of SIRT1, this study reveals the molecular mechanisms underlying the protective effect of hydrogen, which provides a new theoretical basis for clinical application of hydrogen.	Hydrogen	87-95	sirtuin 1	Rattus norvegicus	135-140
28422389-2	2017	Both nitrating systems can dose-dependently induce triosephosphate isomerase (TIM) nitration, however, heme-H2 O2 -NaNO2 was less destructive to protein secondary structures and led to more nitrated tyrosine residue than 3-morpholinosydnonimine hydrochloride (SIN-1, a peroxynitrite donor).	Hydrogen	108-110	triosephosphate isomerase 1	Homo sapiens	51-76
28422389-2	2017	Both nitrating systems can dose-dependently induce triosephosphate isomerase (TIM) nitration, however, heme-H2 O2 -NaNO2 was less destructive to protein secondary structures and led to more nitrated tyrosine residue than 3-morpholinosydnonimine hydrochloride (SIN-1, a peroxynitrite donor).	Hydrogen	108-110	triosephosphate isomerase 1	Homo sapiens	78-81
28422389-3	2017	Both of desferrioxamine and catechin could inhibit TIM nitration induced by heme-H2 O2 -NaNO2 and SIN-1 and protein oxidation induced by SIN-1, but promoted heme-H2 O2 -NaNO2 -induced protein oxidation.	Hydrogen	81-83	triosephosphate isomerase 1	Homo sapiens	51-54
28422389-2	2017	Both nitrating systems can dose-dependently induce triosephosphate isomerase (TIM) nitration, however, heme-H2 O2 -NaNO2 was less destructive to protein secondary structures and led to more nitrated tyrosine residue than 3-morpholinosydnonimine hydrochloride (SIN-1, a peroxynitrite donor).	Hydrogen	108-110	MAPK associated protein 1	Homo sapiens	260-265
28453246-6	2017	It is shown that ANF/GO deposition proceeds by hydrogen bonding and pi-pi interactions, leading to linear growth (1.2 nm/layer pairs) and a composition of 75 wt % ANFs and 25 wt % GO sheets.	Hydrogen	47-55	natriuretic peptide A	Homo sapiens	17-20
27691399-9	2017	Suitable position and orientation of GLU in residue 100 of 7D12 against related amino acids of EGFR formed some extra hydrogen and electrostatic interactions which resulted in binding enhancement.	Hydrogen	118-126	epidermal growth factor receptor	Homo sapiens	95-99
30042973-5	2017	In the region of penumbra, determined via T2-weighted 1H MRI, both [1-13C]pyruvate delivery and [1-13C]pyruvate cellular uptake independently increased.	Hydrogen	54-56	tetraspanin 33	Homo sapiens	17-25
28513720-2	2017	We demonstrate herein, firstly, that the DFT calculated OH 1H NMR chemical shifts of acetylacetone and dibenzoylmethane exhibit a strong linear dependence on the computed OO hydrogen bond length of ~-50 ppm A-1 and as a function of the O-HO bond angle of ~1 ppm per degree, upon the transfer of the hydrogen atom from the ground state toward the transition state.	Hydrogen	59-61	BCL2 related protein A1	Homo sapiens	207-210
28513720-2	2017	We demonstrate herein, firstly, that the DFT calculated OH 1H NMR chemical shifts of acetylacetone and dibenzoylmethane exhibit a strong linear dependence on the computed OO hydrogen bond length of ~-50 ppm A-1 and as a function of the O-HO bond angle of ~1 ppm per degree, upon the transfer of the hydrogen atom from the ground state toward the transition state.	Hydrogen	174-182	BCL2 related protein A1	Homo sapiens	207-210
28513720-2	2017	We demonstrate herein, firstly, that the DFT calculated OH 1H NMR chemical shifts of acetylacetone and dibenzoylmethane exhibit a strong linear dependence on the computed OO hydrogen bond length of ~-50 ppm A-1 and as a function of the O-HO bond angle of ~1 ppm per degree, upon the transfer of the hydrogen atom from the ground state toward the transition state.	Hydrogen	299-307	BCL2 related protein A1	Homo sapiens	207-210
28674221-5	2017	In addition, we also determined the allele frequencies of CYP3A4*1A and CYP3A4*1H were 82.29% and 28.13%, respectively.	Hydrogen	79-81	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-78
28463369-3	2017	Herein, we provide the first account of the molecular impact of the Thr91 mutation on c-Src resistance to experimental drug UM-164 using various computational approaches, namely molecular dynamics simulation, principal component analysis (PCA), dynamic cross-correlation matrices (DCCM) analysis, hydrogen bond occupancy, thermodynamics calculation, ligand-residue interaction and residue interaction networks (RINs).	Hydrogen	297-305	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	86-91
28493688-7	2017	The metabolite of 3"-DMAG by strain AUH-JLD49s was identified as 3"-desmethyl-4"-dehydroxyarctigenin (DMDH-AG) based on electrospray ionization mass spectrometry (ESI-MS) and 1H and 13C nuclear magnetic resonance spectroscopy.	Hydrogen	175-177	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	36-39
28919932-5	2017	From docking studies it was revealed that water and hydrogen-bond networks are essential for substrate binding, thus allowing aliphatic aldehydes to be converted in the charged active site of transketolase.	Hydrogen	52-60	transketolase	Homo sapiens	192-205
28470321-1	2017	A Mn(i) tris(2-pyridylmethyl)amine complex fac-[Mn(kappa3-tpa) (CO)3]+OTf- carries out electrocatalytic hydrogen evolution from neutral water in acetonitrile.	Hydrogen	104-112	FA complementation group C	Homo sapiens	43-46
28453021-4	2017	The hydridic B-H vectors of the B21 anion interact with K+ counterions and, via dihydrogen bonding, also with the partially positively charged hydrogens of the CD sugar units in the modeled beta- and gamma-CD complexes.	Hydrogen	80-90	cytohesin 1	Homo sapiens	32-35
28430446-2	2017	Here we have employed an approach combining amide backbone hydrogen/deuterium exchange coupled with mass spectrometry, fluorescence spectroscopy, and molecular simulations to characterize allosteric patterns of chaperonin GroEL, an ~800 kDa tetradecamer from E. coli.	Hydrogen	59-67	GroEL	Escherichia coli	222-227
28398602-0	2017	Heptacoordinate CoII Complex: A New Architecture for Photochemical Hydrogen Production.	Hydrogen	67-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20
28522797-11	2017	LPS-induced loss of E-cadherin in lung tissues was largely reversed, whereas the acquisition of alpha-SMA was dramatically decreased by hydrogen-rich saline treatment.	Hydrogen	136-144	actin alpha 2, smooth muscle, aorta	Mus musculus	96-105
28379848-4	2017	Especially, energetically favorable hydrogen pairs result in less even no atomic distortion of graphene than sp3 hybridization.	Hydrogen	36-44	Sp3 transcription factor	Homo sapiens	109-112
28453021-4	2017	The hydridic B-H vectors of the B21 anion interact with K+ counterions and, via dihydrogen bonding, also with the partially positively charged hydrogens of the CD sugar units in the modeled beta- and gamma-CD complexes.	Hydrogen	143-152	cytohesin 1	Homo sapiens	32-35
28394038-12	2017	The activities of CBS, CSE, and levels of H2 S were restored in HHcy animals administered H2 S. Exogenous H2 S also ameliorated behavioral deficits accompanied by significant increase in catecholamines.	Hydrogen	90-92	cystathionine beta-synthase	Homo sapiens	18-21
28548516-2	2017	Modulations are observed when a preplasma is developed on the rear side of a mum-scale solid-density hydrogen target.	Hydrogen	101-109	latexin	Homo sapiens	77-80
28216037-8	2017	In silico studies implied that rs1062577 A allele can alter the binding capacity of ESR1 mRNA and miRNAs via either breakage or formation of hydrogen bonds.	Hydrogen	141-149	estrogen receptor 1	Homo sapiens	84-88
28177715-6	2017	H2 peak was lower in GC2 on CHO-S (mean (CI): 6 (4-8) ppm) compared with CHO-F (9 (6-12) ppm) and PLA (12 (2-21) ppm) (trial x time: p &lt; 0.001).	Hydrogen	0-2	solute carrier family 25 member 18	Homo sapiens	21-24
28467497-7	2017	Increases in the expression of anti-oxidative enzymes underlying the Nrf2 pathway in H2-treated cells indicated that mild stress caused by H2 induced increased resistance to exacerbated oxidative stress.	Hydrogen	85-87	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
28467497-7	2017	Increases in the expression of anti-oxidative enzymes underlying the Nrf2 pathway in H2-treated cells indicated that mild stress caused by H2 induced increased resistance to exacerbated oxidative stress.	Hydrogen	139-141	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
28496315-9	2017	RESULTS: The results showed that hydrogen inhalation significantly reduced the number of inflammatory cells in the bronchoalveolar lavage fluid, and the mRNA and protein expression levels of tumor necrosis factor alpha, IL-6, IL-17, IL-23, matrix metalloproteinase-12, caspase-3, and caspase-8, but increased the tissue inhibitor of metalloproteinase-1 expression.	Hydrogen	33-41	tumor necrosis factor	Rattus norvegicus	191-218
28496315-9	2017	RESULTS: The results showed that hydrogen inhalation significantly reduced the number of inflammatory cells in the bronchoalveolar lavage fluid, and the mRNA and protein expression levels of tumor necrosis factor alpha, IL-6, IL-17, IL-23, matrix metalloproteinase-12, caspase-3, and caspase-8, but increased the tissue inhibitor of metalloproteinase-1 expression.	Hydrogen	33-41	interleukin 6	Rattus norvegicus	220-224
28171841-2	2017	Firstly, this substrate was fed directly to the MEC to get the initial feedback about its H2 generation potential.	Hydrogen	90-92	C-C motif chemokine ligand 28	Homo sapiens	48-51
28171841-6	2017	The MEC operated with the dark fermentation effluent, containing a high portion of carbohydrates and low amount of organic acids, produced significant amount of undesired methane simultaneously with H2.	Hydrogen	199-201	C-C motif chemokine ligand 28	Homo sapiens	4-7
28171841-7	2017	Overall, the best MEC behavior was attained using the effluent of the methanogenic reactor and therefore, considering a two-stage system, methanogenesis is an advisable pretreatment step for the acidic CW to enhance the H2 formation in complementary microbial electrohydrogenesis.	Hydrogen	220-222	C-C motif chemokine ligand 28	Homo sapiens	18-21
28194737-10	2017	The deuterium on Tyr amide of neurotensin (9-13), Arg-Pro-Tyr-Ile-Leu, migrated significantly faster than that on Ile or Leu amides, indicating the loss of deuterium from the original sites is not mere randomization of hydrogen and deuterium but more site-specific phenomena.	Hydrogen	219-227	neurotensin	Homo sapiens	30-41
28251688-5	2017	Therefore, we speculated that H2 S antagonizes FA-induced neurotoxicity by modulating ALDH2.	Hydrogen	30-32	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	86-91
28251688-9	2017	Furthermore, we found that H2 S reverses FA-elicited upregulation of ALDH2 in PC12 cells.	Hydrogen	27-29	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	69-74
27050329-5	2017	As a result, AKR specifically binds in site I of HSA through hydrogen bonds, van der Waals force, and electrostatic interaction.	Hydrogen	61-69	albumin	Homo sapiens	49-52
28346551-0	2017	Infrared spectra of HSCS+, c-HSCS, and HCS2- produced on electron bombardment of CS2 in solid para-hydrogen.	Hydrogen	94-107	chorionic somatomammotropin hormone 2	Homo sapiens	40-43
28295323-7	2017	Docking analysis and molecular dynamics simulations identified a conserved serine in CB1 R (S468) and mGlu8a R (S894) that forms a hydrogen bond with the peptide backbone of CRIP1a at position R82.	Hydrogen	131-139	cannabinoid receptor 1	Homo sapiens	85-90
28452367-2	2017	Herein, we report that diolefin-ruthenium complexes containing the chemically and redox non-innocent ligand trop2dad catalyse the production of H2 from formaldehyde and water in the presence of a base.	Hydrogen	144-146	tumor associated calcium signal transducer 2	Homo sapiens	108-113
28406297-6	2017	Although several hydrogen bonds between ligands and AChE do appear, no significant values of BIEs have been recorded.	Hydrogen	17-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-56
28188779-0	2017	Inhalation of high concentrations of hydrogen ameliorates liver ischemia/reperfusion injury through A2A receptor mediated PI3K-Akt pathway.	Hydrogen	37-45	thymoma viral proto-oncogene 1	Mus musculus	127-130
28188779-1	2017	BACKGROUND AND AIMS: This study explored the hepatoprotection of high concentrations of hydrogen (HCH) inhalation in a mouse hepatic ischemia/reperfusion (I/R) injury model and the potential mechanism.	Hydrogen	88-96	dedicator of cyto-kinesis 2	Mus musculus	98-101
28401962-3	2017	The results show that tribochemical reactions promoted by the oil lubrication generate strong structural changes in the carbon hybridization of the ta-C hydrogen-free carbon, with initially high sp3 content.	Hydrogen	153-161	Sp3 transcription factor	Homo sapiens	195-198
28386062-0	2017	Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C.	Hydrogen	6-15	troponin C1, slow skeletal and cardiac type	Homo sapiens	137-155
28368101-5	2017	Like EcDHFR, Salmonella enterica DHFR shows experimental evidence of a large-scale conformational change following hydride transfer that relies on conservation of a key hydrogen bonding interaction between the M20 and GH loops, directly comparable to the closed-to-occluded conformational change observed in EcDHFR.	Hydrogen	169-177	dihydrofolate reductase	Escherichia coli	5-11
28371253-4	2017	We used neutron diffraction to determine the positions of the hydrogen atoms in the ligands aniline and 2-aminopyridine bound to the archetypical serine protease trypsin.	Hydrogen	62-70	coagulation factor II, thrombin	Homo sapiens	146-161
27984827-3	2017	The zwitterionic fluorescent polymer bound to bacteria through ionic complexes between anionic groups on the bacterial surface and cationic BOD/BE-PSM groups after 1h incubation.	Hydrogen	164-166	folate hydrolase 1	Homo sapiens	147-150
28249778-3	2017	Here, we report amide hydrogen/deuterium exchange data that reveal long-range allosteric changes in the NFkappaB (RelA-p50) heterodimer induced by DNA or IkappaBalpha binding.	Hydrogen	22-30	nuclear factor kappa B subunit 1	Homo sapiens	104-112
28249778-3	2017	Here, we report amide hydrogen/deuterium exchange data that reveal long-range allosteric changes in the NFkappaB (RelA-p50) heterodimer induced by DNA or IkappaBalpha binding.	Hydrogen	22-30	NFKB inhibitor alpha	Homo sapiens	154-166
28296399-4	2017	The thermodynamic products of these reactions are low-spin, diamagnetic, Co(III) amido complexes that are either monomeric, when an external hydrogen atom source such as 1,4-cyclohexadiene is present, or dimeric products formed via C-C coupling of the azide aryl group and internal transfer of H  to the nitrogen.	Hydrogen	141-149	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	73-79
28025808-7	2017	Here, we report the 1H, 13C, and 15N backbone resonance assignments of monomeric SOD1 in the absence and presence of the protein crowder lysozyme.	Hydrogen	20-22	superoxide dismutase 1	Homo sapiens	81-85
27696674-7	2017	In addition, five hydrogen bonding interactions of ADP and ATP with residues Lys52, Gln103, Asp104, and Met106 also stabilize bindings of ADP and ATP to extracellular signal-regulated kinase 2.	Hydrogen	18-26	mitogen-activated protein kinase 3	Homo sapiens	153-192
28284870-4	2017	The pharmacophore model provided a minimum structural motif of Cdc7 inhibitor, by which preliminary medicinal chemistry efforts identified a dihydrothieno[3,2-d]-pyrimidin-4(1H)-one scaffold having a heteroaromatic hinge-binding moiety.	Hydrogen	174-176	cell division cycle 7	Homo sapiens	63-67
28115241-6	2017	Hydrogen bonding was characteristic of the interaction between PFCs and hPXR.	Hydrogen	0-8	nuclear receptor subfamily 1 group I member 2	Homo sapiens	72-76
28082096-2	2017	In an observational cohort study we aimed to assess how patients with elevated high-sensitivity cardiac troponin T (hs-cTnT) levels, and no MI are investigated and followed up, compared to patients with MI.	Hydrogen	116-118	troponin T2, cardiac type	Homo sapiens	119-123
28168755-0	2017	Palbociclib can overcome mutations in cyclin dependent kinase 6 that break hydrogen bonds between the drug and the protein.	Hydrogen	75-83	cyclin dependent kinase 6	Homo sapiens	38-63
28064094-9	2017	Greater changes were found with HSA, mainly triggered by hydrogen bonds and the electrostatic interaction properties of dendritic glycopolymers.	Hydrogen	57-65	albumin	Homo sapiens	32-35
27921259-5	2017	Very recently, we showed that also the fully extended form of highly charged protein ions can adopt a distinct type of secondary structure that features a characteristic C5-type hydrogen bond pattern.	Hydrogen	178-186	ubiquitin specific peptidase like 1	Homo sapiens	62-84
28196708-5	2017	Docking results showed that compound 4c played a key role to form integral hydrogen bonds and a pi-pi stacking interaction, using hydrazide scaffold (CONN) and pyrazole ring respectively, with PDE4B protein.	Hydrogen	75-83	phosphodiesterase 4B	Homo sapiens	193-198
30023623-9	2017	MD simulation results showed the highest hydrogen bond occupancy and van der Waals interactions were between the side chains of BBZ-ARO and the DNA grooves.	Hydrogen	41-49	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	132-135
27984751-3	2017	The specific cation recognition ability of chemosensor towards Sn2+ was investigated by experimental (UV-visible, fluorescence spectroscopy, 1H NMR, 13C NMR, FTIR and HRMS) methods and further supported by Density Functional Theory study.	Hydrogen	141-143	solute carrier family 38 member 5	Homo sapiens	63-66
28386342-0	2017	Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels.	Hydrogen	0-8	caspase 3	Homo sapiens	51-60
28119123-3	2017	1H and 19F NMR investigations suggest the formation of an inclusion complex of F-DOPA with beta-CD.	Hydrogen	0-2	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	91-98
28282025-5	2017	All NESs also participate in main chain hydrogen bonding with human CRM1 Lys568 side chain, which acts as a specificity filter that prevents binding of non-NES peptides.	Hydrogen	40-48	nestin	Homo sapiens	4-7
28386342-4	2017	This study aimed to investigate the protective effect of hydrogen, a novel antioxidant, against isoflurane-induced caspase-3 activation and cognitive impairment.	Hydrogen	57-65	caspase 3	Homo sapiens	115-124
28352256-12	2017	Overall, NOP and AQ increased the amount of reduced volatile fatty acids, but part of [2H] spared from methanogenesis was lost as gaseous H2.	Hydrogen	138-140	prepronociceptin	Homo sapiens	9-12
28098910-5	2017	H2-rich saline improved fasting blood glucose, fasting insulin, insulin sensitivity and glucose tolerance, and lowered the expression levels of tumor necrosis factor alpha, interleukin-1 beta, 3-nitrotyrosine and 8-hydroxy-2"-deoxyguanosine in the liver.	Hydrogen	0-2	tumor necrosis factor	Rattus norvegicus	144-171
27394141-4	2017	Here we have mapped the FN interaction site of human TG2 by use of hydrogen/deuterium exchange coupled with mass spectrometry, and we confirm that the FN-binding site is located in the N-terminal domain of TG2.	Hydrogen	67-75	fibronectin 1	Homo sapiens	24-26
27394141-4	2017	Here we have mapped the FN interaction site of human TG2 by use of hydrogen/deuterium exchange coupled with mass spectrometry, and we confirm that the FN-binding site is located in the N-terminal domain of TG2.	Hydrogen	67-75	transglutaminase 2	Homo sapiens	53-56
27394141-4	2017	Here we have mapped the FN interaction site of human TG2 by use of hydrogen/deuterium exchange coupled with mass spectrometry, and we confirm that the FN-binding site is located in the N-terminal domain of TG2.	Hydrogen	67-75	transglutaminase 2	Homo sapiens	206-209
28153358-3	2017	Whereas, molecular docking studies were performed with the active site of cyclooxygenase-2 to identify hydrogen bonding, hydrophobic and ionic interactions between protein and ligands.	Hydrogen	103-111	prostaglandin-endoperoxide synthase 2	Homo sapiens	74-90
27596480-5	2017	The use of H2 S as co-electron donor resulted in a 13-fold increase in NO3- removal rates (~18 gNO3-  m-3  h-1 ) and complete denitrification under steady-state conditions, which was supported by higher abundances of narG, nirK, and nosZ denitrifying genes.	Hydrogen	11-13	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
26999261-5	2017	The microenvironment of HSA have also been studied using synchronous fluorescence spectroscopy, and the feature of thiadiazole derivative-induced structural changes of HSA have been carried using Fourier transform infrared spectroscopy and the Molecular modelling simulations explore the hydrophobic and hydrogen bonding interactions.	Hydrogen	304-312	albumin	Homo sapiens	168-171
28062799-5	2017	Here we dissect the molecular origins of excessive FcRn binding in therapeutic IgGs using a combination of hydrogen/deuterium exchange mass spectrometry and FcRn affinity chromatography.	Hydrogen	107-115	Fc gamma receptor and transporter	Homo sapiens	51-55
28038418-1	2017	The aim of this work was to study the sorption kinetics and thermodynamics of Co(II) and Ni(II) from aqueous solutions by sorbents on the basis of hydrogen (PD-1) and tertiary (PD-2) Ca-Mg phosphates depending on the solution temperature and sorbents chemical composition.	Hydrogen	147-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
28364439-9	2017	Similarly, pro-inflammatory cytokine levels (interleukin-1beta and interleukin-6) in the left lung were significantly lower in the hydrogen-rich saline group than in the normal saline group ( P  &lt; 0.05).	Hydrogen	131-139	interleukin 1 beta	Rattus norvegicus	45-62
28364439-9	2017	Similarly, pro-inflammatory cytokine levels (interleukin-1beta and interleukin-6) in the left lung were significantly lower in the hydrogen-rich saline group than in the normal saline group ( P  &lt; 0.05).	Hydrogen	131-139	interleukin 6	Rattus norvegicus	67-80
28098910-5	2017	H2-rich saline improved fasting blood glucose, fasting insulin, insulin sensitivity and glucose tolerance, and lowered the expression levels of tumor necrosis factor alpha, interleukin-1 beta, 3-nitrotyrosine and 8-hydroxy-2"-deoxyguanosine in the liver.	Hydrogen	0-2	interleukin 1 beta	Rattus norvegicus	173-191
27886413-0	2017	Noble-Metal-Free Photocatalytic Hydrogen Evolution Activity: The Impact of Ball Milling Anatase Nanopowders with TiH2.	Hydrogen	32-40	RuvB like AAA ATPase 2	Homo sapiens	113-117
28290719-3	2017	Similarly, the pharmacophore model for EGFR (T790M) (r2 = 0.92, q2 = 0.72) suggested that the presence of a hydrogen bond acceptor, two hydrogen bond donors and a hydrophobic group plays vital role in binding of an inhibitor of EGFR (T790M).	Hydrogen	108-116	epidermal growth factor receptor	Homo sapiens	39-43
28290719-3	2017	Similarly, the pharmacophore model for EGFR (T790M) (r2 = 0.92, q2 = 0.72) suggested that the presence of a hydrogen bond acceptor, two hydrogen bond donors and a hydrophobic group plays vital role in binding of an inhibitor of EGFR (T790M).	Hydrogen	108-116	epidermal growth factor receptor	Homo sapiens	228-232
28290719-3	2017	Similarly, the pharmacophore model for EGFR (T790M) (r2 = 0.92, q2 = 0.72) suggested that the presence of a hydrogen bond acceptor, two hydrogen bond donors and a hydrophobic group plays vital role in binding of an inhibitor of EGFR (T790M).	Hydrogen	136-144	epidermal growth factor receptor	Homo sapiens	39-43
28349780-5	2017	The receptor-based molecular docking reveals the best binding interaction of nuclear factor erythroid 2-related factor 2 and ganoderic acid A with GScore (-9.69) (kcal/mol), Lipophilic EvdW (-1.83), Electro (-0.72), Glide emodel (-73.369), H bond (-1.1), molecular mechanics/generalized Born surface area (-75.541) with Leu 718, Asp 800, Cys 797 residues involved in hydrogen bonding.	Hydrogen	367-375	NFE2 like bZIP transcription factor 2	Homo sapiens	77-120
28198485-1	2017	Hydrogen-bond supported intercalation compounds constructed from three types of two-dimensional layers and common guests, {(Hha)2[Cu(CA)2(EtOH)2]}n (1), {(Hha)2[Cu(CA)2(EtOH)]}n (2), and {(Hha)2[Cu(CA)2]}n (3) (ha = hexylamine), have been synthesized and characterized.	Hydrogen	0-8	keratin 32	Homo sapiens	124-129
28198485-1	2017	Hydrogen-bond supported intercalation compounds constructed from three types of two-dimensional layers and common guests, {(Hha)2[Cu(CA)2(EtOH)2]}n (1), {(Hha)2[Cu(CA)2(EtOH)]}n (2), and {(Hha)2[Cu(CA)2]}n (3) (ha = hexylamine), have been synthesized and characterized.	Hydrogen	0-8	keratin 32	Homo sapiens	155-160
28198485-1	2017	Hydrogen-bond supported intercalation compounds constructed from three types of two-dimensional layers and common guests, {(Hha)2[Cu(CA)2(EtOH)2]}n (1), {(Hha)2[Cu(CA)2(EtOH)]}n (2), and {(Hha)2[Cu(CA)2]}n (3) (ha = hexylamine), have been synthesized and characterized.	Hydrogen	0-8	keratin 32	Homo sapiens	155-160
27506680-7	2017	An elevated hs-cTnT was present in 54% of patients with HighT2 (15/28) compared with 14% of patients without HighT2 (10/73) (p&lt;0.001).	Hydrogen	12-14	troponin T2, cardiac type	Homo sapiens	15-19
28178790-1	2017	We use a new high-accuracy all-dimensional potential to compute the cross second virial coefficient B12(T) between molecular hydrogen and carbon monoxide.	Hydrogen	125-133	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	100-103
28094522-5	2017	Structural variations were found in the CoII-O bond lengths that range from 1.953(4) to 2.051(3) A; this range in bond lengths were attributed to the differences in the intramolecular hydrogen bonds that surround the hydroxido ligand.	Hydrogen	184-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-44
28121422-7	2017	Moreover, Pd atoms on the alloy surface can be stabilized by hydrogen adsorption, forming Pd-H bonds, which are stronger than Au-H bonds.	Hydrogen	61-69	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	90-94
28256219-4	2017	Specifically, we use shape fluctuation analysis and sonication-induced scission in combination with full-atom molecular dynamics simulations to reveal that the amyloid fibrils of the mammalian prion protein PrP are mechanically unstable, most likely due to a very low hydrogen bond density in the fibril structure.	Hydrogen	268-276	prion protein	Homo sapiens	207-210
28055196-5	2017	Optimization of compound AQ-390/10779040 (IC50 = 4.6 muM) from the virtual screening, which holds a novel scaffold of benzo[cd]indol-2(1H)-one among PDE inhibitors, leads to discovery of a new compound LHB-8 with a significant improvement of inhibition (IC50 = 570 nM).	Hydrogen	135-137	latexin	Homo sapiens	53-56
28293084-0	2017	Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression.	Hydrogen	0-8	heme oxygenase 1	Mus musculus	129-145
28167786-5	2017	NMR and amide hydrogen-deuterium exchange mass spectrometry showed that the IkappaBalpha(5xPEST) appears to be "caught in the act of stripping" because it is not yet completely in the folded and NFkappaB-bound state.	Hydrogen	14-22	NFKB inhibitor alpha	Homo sapiens	76-88
28251074-8	2017	LPS at concentrations of 300 ng/mL for 1h significantly stimulated the mRNA expression of IL-8, IL-6, IL-1beta, TNF-alpha, and TGF-beta in HCECs, while the stimulation effects were significantly inhibited by AA (20 micromol/L).	Hydrogen	39-41	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
28251074-8	2017	LPS at concentrations of 300 ng/mL for 1h significantly stimulated the mRNA expression of IL-8, IL-6, IL-1beta, TNF-alpha, and TGF-beta in HCECs, while the stimulation effects were significantly inhibited by AA (20 micromol/L).	Hydrogen	39-41	interleukin 6	Homo sapiens	96-100
28251074-8	2017	LPS at concentrations of 300 ng/mL for 1h significantly stimulated the mRNA expression of IL-8, IL-6, IL-1beta, TNF-alpha, and TGF-beta in HCECs, while the stimulation effects were significantly inhibited by AA (20 micromol/L).	Hydrogen	39-41	interleukin 1 beta	Homo sapiens	102-110
28251074-8	2017	LPS at concentrations of 300 ng/mL for 1h significantly stimulated the mRNA expression of IL-8, IL-6, IL-1beta, TNF-alpha, and TGF-beta in HCECs, while the stimulation effects were significantly inhibited by AA (20 micromol/L).	Hydrogen	39-41	tumor necrosis factor	Homo sapiens	112-121
28251074-8	2017	LPS at concentrations of 300 ng/mL for 1h significantly stimulated the mRNA expression of IL-8, IL-6, IL-1beta, TNF-alpha, and TGF-beta in HCECs, while the stimulation effects were significantly inhibited by AA (20 micromol/L).	Hydrogen	39-41	transforming growth factor beta 1	Homo sapiens	127-135
28090721-1	2017	A robust hydrogen-bonded organic framework HOF-TCBP (H4 TCBP=3,3",5,5"-tetrakis-(4-carboxyphenyl)-1,1"-biphenyl) has been successfully constructed and structurally characterized.	Hydrogen	9-17	TIA1 cytotoxic granule associated RNA binding protein like 1	Homo sapiens	47-51
28090721-1	2017	A robust hydrogen-bonded organic framework HOF-TCBP (H4 TCBP=3,3",5,5"-tetrakis-(4-carboxyphenyl)-1,1"-biphenyl) has been successfully constructed and structurally characterized.	Hydrogen	9-17	TIA1 cytotoxic granule associated RNA binding protein like 1	Homo sapiens	56-60
28881687-0	2017	OGTT 1h serum C-peptide to plasma glucose concentration ratio is more related to beta cell function and diabetes mellitus.	Hydrogen	5-7	insulin	Homo sapiens	14-23
28881687-10	2017	Both C-peptide index 1h (Exp(beta) = 0.28, p&lt;0.001) and 2h (Exp(beta) = 0.42, p&lt;0.001) were independently associated with disposition index, but the OR of C-peptide index 1h for diabetes was much lower.	Hydrogen	21-23	insulin	Homo sapiens	5-14
28881687-10	2017	Both C-peptide index 1h (Exp(beta) = 0.28, p&lt;0.001) and 2h (Exp(beta) = 0.42, p&lt;0.001) were independently associated with disposition index, but the OR of C-peptide index 1h for diabetes was much lower.	Hydrogen	21-23	insulin	Homo sapiens	161-170
29762002-11	2017	Conclusion: Hydrogen-rich saline attenuated PWT and inhibited the release of cytokines TNF-alpha,IL-1beta,IL-6 in rats with PHN via activating autophagy.	Hydrogen	12-20	tumor necrosis factor	Rattus norvegicus	87-96
27826791-7	2017	Structural and energetic analysis identified two anchor residues Phe60 and Ser65 in cyclic peptide that can form a pi-pi stacking and a hydrogen bonding with the residues Trp30 and His68 of TGF-beta, respectively, conferring high stability and specificity to the complex system.	Hydrogen	136-144	transforming growth factor beta 1	Homo sapiens	190-198
29744302-3	2017	The reduction of TCE under 90 mA current, 1 mL min-1 flow rate, and 1 mg L-1 initial TCE concentration, was inhibited in the presence of humic acids due to competition for direct electron transfer and/or reaction with atomic hydrogen produced at the cathode surface by water electrolysis.	Hydrogen	225-233	immunoglobulin kappa variable 1-16	Homo sapiens	73-76
28093592-3	2017	Moreover, it was found that ET-1 can form a 1 : 1 Py(N)-B complex with boron trifluoride and a hydrogen-bonded proton transfer (Py(N)-H) complex with trifluoroacetic acid, which exhibit photoabsorption and fluorescence bands at a longer wavelength region than the pristine ET-1.	Hydrogen	95-103	endothelin 1	Homo sapiens	28-32
29762002-11	2017	Conclusion: Hydrogen-rich saline attenuated PWT and inhibited the release of cytokines TNF-alpha,IL-1beta,IL-6 in rats with PHN via activating autophagy.	Hydrogen	12-20	interleukin 1 beta	Rattus norvegicus	97-105
29762002-11	2017	Conclusion: Hydrogen-rich saline attenuated PWT and inhibited the release of cytokines TNF-alpha,IL-1beta,IL-6 in rats with PHN via activating autophagy.	Hydrogen	12-20	interleukin 6	Rattus norvegicus	106-110
28096372-0	2017	Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry.	Hydrogen	80-88	apolipoprotein E	Homo sapiens	52-69
27999834-4	2017	The structure of the C18/EA/SMCC/FITC-g-PSI copolymer was confirmed using 1H-NMR and FTIR spectroscopy, and its cell binding ability was investigated by flow cytometry and confocal laser scanning microscopy.	Hydrogen	74-76	Bardet-Biedl syndrome 9	Homo sapiens	21-24
27628439-4	2017	Aim of this study was investigating all these different conditions of diabetes risk, with specific focus on possible insulin sensitivity and beta-cell function changes, when 1h-HG, and further HbA1c-prediabetes, are added to the already deeply studied condition of IFG/IGT.	Hydrogen	174-176	insulin	Homo sapiens	117-124
28050609-3	2017	This paper uses contemporary computational methods to determine the reaction pathways involved; depending on the substrate, the aryl radical underwent (i) SRN1 onto the enolate anion of the acetylarene, (ii) aryl-aryl bond formation, (iii) tandem hydrogen atom abstraction followed by SRN1 cyclisation and even (iv) ArC-N cleavage.	Hydrogen	247-255	NPHS2 stomatin family member, podocin	Homo sapiens	155-159
28134283-1	2017	Dual amide hydrogen bond crosslinked and strengthened high strength supramolecular polymer conductive hydrogels were fabricated by simply in situ doping poly (N-acryloyl glycinamide-co-2-acrylamide-2-methylpropanesulfonic) (PNAGA-PAMPS) hydrogels with PEDOT/PSS.	Hydrogen	11-19	PSS	Homo sapiens	258-261
27750148-6	2017	Molecular dynamics simulations illustrated that the more stable hydrogen bond interaction of the UA derivative 12e with Ser191 and stronger hydrophobic interactions with Val198, Phe463 than those of OA derivative 12b mainly led to their significantly different CETP inhibitory activity.	Hydrogen	64-72	cholesteryl ester transfer protein	Homo sapiens	261-265
28050609-3	2017	This paper uses contemporary computational methods to determine the reaction pathways involved; depending on the substrate, the aryl radical underwent (i) SRN1 onto the enolate anion of the acetylarene, (ii) aryl-aryl bond formation, (iii) tandem hydrogen atom abstraction followed by SRN1 cyclisation and even (iv) ArC-N cleavage.	Hydrogen	247-255	NPHS2 stomatin family member, podocin	Homo sapiens	285-289
28109213-2	2017	On Cu(100) and Cu(111) surfaces, an sp2-type network of carbons can be automatically formed with the help of hydrogen under very low carbon coverages.	Hydrogen	109-117	Sp2 transcription factor	Homo sapiens	36-39
27966811-1	2017	Visible-light irradiation of a ternary hybrid catalyst prepared by grafting a dye, an H2 evolving CoIII catalyst and a CO-producing ReI catalyst on TiO2 have been found to produce both H2 and CO (syngas) in CO2 -saturated N,N-dimethyl formamide (DMF)/water solution containing a 0.1 m sacrificial electron donor.	Hydrogen	86-88	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	98-103
27966811-2	2017	The H2 /CO ratios are effectively controlled by changing either the water content of the solvent or the molar ratio of the ReI and CoIII catalysts ranging from 1:2 to 15:1.	Hydrogen	4-6	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	131-136
27973771-7	2017	The methylene groups of R provide an experimental probe of the magnetic anisotropy and aromaticity of the C18 ring through the progressive NMR shielding of the 1H nuclei from ca.	Hydrogen	160-162	Bardet-Biedl syndrome 9	Homo sapiens	106-109
28082569-0	2017	Pin the tail on the hydrogens.	Hydrogen	20-29	dynein light chain LC8-type 1	Homo sapiens	0-3
27908753-6	2017	The uptake of 68Ga-Z01115 in B1R-positive (B1R+) tumor was 5.65+-0.59%ID/g at 1h post-injection.	Hydrogen	78-80	bradykinin receptor, beta 1	Mus musculus	29-33
27908753-6	2017	The uptake of 68Ga-Z01115 in B1R-positive (B1R+) tumor was 5.65+-0.59%ID/g at 1h post-injection.	Hydrogen	78-80	bradykinin receptor, beta 1	Mus musculus	29-32
27816890-0	2017	Modulating hydrogen-bond basicity within the context of protein-ligand binding: A case study with thrombin inhibitors that reveals a dominating role for desolvation.	Hydrogen	11-19	coagulation factor II, thrombin	Homo sapiens	98-106
28098802-8	2017	In addition, molecular docking simulation indicated that penduliflaworosin could form hydrogen bonds within the ATP-binding region of the VEGF receptor-2 kinase unit.	Hydrogen	86-94	vascular endothelial growth factor A	Homo sapiens	138-142
27966954-1	2017	The discovery of a novel potent type II ABL/c-KIT dual kinase inhibitor compound 34 (CHMFL-ABL/KIT-155), which utilized a hydrogen bond formed by NH on the kinase backbone and carbonyl oxygen of 34 as a unique hinge binding, is described.	Hydrogen	122-130	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	44-49
27831934-8	2017	Further, we show that SPC/E hydrogen-bond (HB) lifetimes deviate from Arrhenious behaviour at low temperatures in contrast with some previous MD studies.	Hydrogen	28-36	proline rich protein gene cluster	Homo sapiens	22-25
27835873-4	2017	6-OAP formed hydrogen bonds with Ser611/Ser613/Arg609 at the SH2 domain of STAT3 and inhibited the constitutive and interleukin-6-induced phosphorylated STAT3 (pSTAT3), leading to inhibitory effects on lung cancer cells and suppression of Skp2 transcription.	Hydrogen	13-21	signal transducer and activator of transcription 3	Homo sapiens	75-80
27835873-4	2017	6-OAP formed hydrogen bonds with Ser611/Ser613/Arg609 at the SH2 domain of STAT3 and inhibited the constitutive and interleukin-6-induced phosphorylated STAT3 (pSTAT3), leading to inhibitory effects on lung cancer cells and suppression of Skp2 transcription.	Hydrogen	13-21	interleukin 6	Homo sapiens	116-129
27959375-3	2017	Magnetic measurements show the coercivity of these FePt NPs is as high as 3.6 T. Comparison of NPs synthesized under the Ar and Ar/H2 atmospheres shows that the presence of H2 in the annealing environment influences the nucleation and promotes the growth of L10-FePt NPs.	Hydrogen	173-175	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	258-261
27861147-6	2017	Atn inhibited STAT3 binding to genomic DNA by disrupting hydrogen bond linking between DNA and STAT3.	Hydrogen	57-65	signal transducer and activator of transcription 3	Homo sapiens	14-19
27976874-1	2017	The complex Ir2S2(PPh3)4 (1) is known to react with 1 and 2 equivalents of H2 leading to [Ir(H)(PPh3)2]2(mu-S)2 (2) and Ir2(mu-S)(mu-SH)(mu-H)H2(PPh3)4 (4), respectively ( Linck , R. C. ; Pafford , R. J. ; Rauchfuss , T. B. J.	Hydrogen	75-77	caveolin 1	Homo sapiens	18-22
27976874-1	2017	The complex Ir2S2(PPh3)4 (1) is known to react with 1 and 2 equivalents of H2 leading to [Ir(H)(PPh3)2]2(mu-S)2 (2) and Ir2(mu-S)(mu-SH)(mu-H)H2(PPh3)4 (4), respectively ( Linck , R. C. ; Pafford , R. J. ; Rauchfuss , T. B. J.	Hydrogen	75-77	caveolin 1	Homo sapiens	96-100
27976874-1	2017	The complex Ir2S2(PPh3)4 (1) is known to react with 1 and 2 equivalents of H2 leading to [Ir(H)(PPh3)2]2(mu-S)2 (2) and Ir2(mu-S)(mu-SH)(mu-H)H2(PPh3)4 (4), respectively ( Linck , R. C. ; Pafford , R. J. ; Rauchfuss , T. B. J.	Hydrogen	75-77	caveolin 1	Homo sapiens	96-100
27861147-6	2017	Atn inhibited STAT3 binding to genomic DNA by disrupting hydrogen bond linking between DNA and STAT3.	Hydrogen	57-65	signal transducer and activator of transcription 3	Homo sapiens	95-100
27428516-6	2017	The motif, formed by the fusion of a helix and a type VIa beta-turn, contains a hydrogen bond between the side chain of X(-1) and the side chain/backbone of X(3) , a alpha-helical hydrogen bond between X(-2) and X(2) and stacking interaction between cisPro and an aromatic residue at X(1) .	Hydrogen	80-88	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	157-161
27989622-6	2017	The interfaces between PI4KIIIbeta-ACBD3 and ACBD3-3A were mapped with hydrogen-deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	71-79	phosphatidylinositol 4-kinase beta	Homo sapiens	23-40
27141882-13	2017	In molecular modelling studies, CS-2 exhibited various hydrophobic as well as hydrogen bonding interactions at colchicine binding site and was found to be stabilized in this cavity.	Hydrogen	78-86	chorionic somatomammotropin hormone 2	Homo sapiens	32-36
28013347-9	2017	Finally, we demonstrated the direct interaction between Ang II and MD2 protein via hydrogen bonds on Arg-90, Glu-92, and Asp-100.	Hydrogen	83-91	angiotensinogen	Rattus norvegicus	56-62
28458345-1	2017	The current research was designed to study the role of hydrogen in renal fibrosis and the renal epithelial to mesenchymal transition (EMT) induced by transforming growth factor-beta1 (TGF-beta1).	Hydrogen	55-63	transforming growth factor beta 1	Homo sapiens	184-193
28618988-4	2017	METHOD: The present work involved the synthesis of a series of newer substituted triazole amine derivatives followed by characterization using FTIR and 1H-NMR spectroscopy and their in silico evaluation by docking studies to determine the binding interactions for the best fit conformations in the binding site of PDE4 protein.	Hydrogen	152-154	phosphodiesterase 4A	Homo sapiens	314-318
28814948-4	2017	On the other hand, bovine serum albumin (BSA) binding constants and thermodynamic parameters suggest spontaneous interactions with this protein by hydrogen bonds and van der Waals forces.	Hydrogen	147-155	albumin	Homo sapiens	26-39
28637410-12	2017	The analysis of these models suggested that the steric factor of R4 position was crucialfor activity of quinazoline-2,4-diones HPPD inhibitors, bulky substitutions might improve thebioactivity of these inhibitors greatly, meanwhile, hydrogen-bond acceptor groups in this positionwere required for higher activity.	Hydrogen	233-241	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	127-131
27771282-4	2017	BCRP activity, when exposed to modulators for 1h, was diminished for most modulators through significant increases in H33342 accumulation at &lt;10microm with 2,6,4-trimethoflavone increasing H33342 intracellular accumulation by 3.7-6.6 fold over 1-100microm.	Hydrogen	46-48	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-4
29040978-0	2017	Hydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3beta Signaling Pathway in Rats.	Hydrogen	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	146-149
31961510-6	2017	The B12 -TiO2 hybrid catalyst was used for hydrogen evolution and alkene reduction by UV light irradiation, and the cobalt-hydrogen complex (Co-H complex) was considered to be a putative intermediate of the reactions.	Hydrogen	43-51	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	4-7
31961510-6	2017	The B12 -TiO2 hybrid catalyst was used for hydrogen evolution and alkene reduction by UV light irradiation, and the cobalt-hydrogen complex (Co-H complex) was considered to be a putative intermediate of the reactions.	Hydrogen	141-145	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	4-7
32355363-0	2017	Mechanical characterisation of polymer of intrinsic microporosity PIM-1 for hydrogen storage applications.	Hydrogen	76-84	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	66-71
28737429-1	2017	In this study, we have employed 1H NMR metabolomics to assess the metabolic responses of PC3 prostate tumour cells to hypoxia and to pharmacological HIF-1alpha inhibition by DES or its polyacetal conjugate tert-DES.	Hydrogen	32-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-159
32355363-7	2017	It was found that the film is thermally stable at low temperatures, down to -150  C, and decomposition of the material occurs at 350  C. These results suggest that PIM-1 has sufficient elasticity to withstand the elastic deformations occurring within state-of-the-art high-pressure hydrogen storage tanks and sufficient thermal stability to be applied at the range of temperatures necessary for gas storage applications.	Hydrogen	282-290	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	164-169
28050723-6	2017	In analogy to CD4, the identified compounds make hydrogen bonds with Asp-368gp120 and multiple van der Waals contacts with the gp120 residues that bind to Phe-43CD4, resulting in destruction of the critical interactions of gp120 with Phe-43CD4 and Arg-59CD4.	Hydrogen	49-57	CD4 molecule	Homo sapiens	14-17
28050723-7	2017	The complexes of the CD4-mimetic candidates with gp120 show relative conformational stability within the molecular dynamics simulations and expose the high percentage occupancies of intermolecular hydrogen bonds, in line with the data on the binding free energy calculations.	Hydrogen	197-205	CD4 molecule	Homo sapiens	21-24
28017350-3	2017	High-sensitivity cardiac troponin T (hs-cTnT) is a sensitive marker of myocardial injury, and predicts incident HF and mortality.	Hydrogen	37-39	troponin T2, cardiac type	Homo sapiens	40-44
27863383-6	2016	We also found that phosphorylated AKT and STAT3 but not the proteins expression reached peak after 1h and 6h treatment of leptin, respectively.	Hydrogen	99-101	AKT serine/threonine kinase 1	Homo sapiens	34-37
27918546-2	2017	We show that the urea transporter (UT-B) can be used as a gene reporter, where reporter expression is detected using 1H MRI measurements of UT-B-mediated increases in plasma membrane water exchange.	Hydrogen	117-119	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	35-39
27918546-2	2017	We show that the urea transporter (UT-B) can be used as a gene reporter, where reporter expression is detected using 1H MRI measurements of UT-B-mediated increases in plasma membrane water exchange.	Hydrogen	117-119	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	140-144
27795378-4	2017	In these first reported structures of a class A beta-lactamase in an acyl-enzyme complex with aztreonam, we directly observed most of the hydrogen atoms (as deuterium) within the active site.	Hydrogen	138-146	amyloid beta precursor protein	Homo sapiens	46-52
27863383-6	2016	We also found that phosphorylated AKT and STAT3 but not the proteins expression reached peak after 1h and 6h treatment of leptin, respectively.	Hydrogen	99-101	signal transducer and activator of transcription 3	Homo sapiens	42-47
27771530-5	2016	In the injured sciatic nerve thrombin levels were elevated as early as 1h after injury, reached their peak 1day after injury which was significantly higher (24.4+-4.1mU/ml) compared to contralateral uninjured nerves (2.6+-7mU/ml, t-test p&lt;0.001) and declined linearly reaching baseline levels by day 7.	Hydrogen	71-73	coagulation factor II, thrombin	Homo sapiens	29-37
27984871-1	2016	A nitrate ion (NO3-) with its trigonal planar geometry and charges distributed among nitrogen and oxygen atoms can couple to the extensive hydrogen bond network of water to give rise to unique dynamical characteristics.	Hydrogen	139-147	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
26866650-10	2017	Additionally, hydrogen tended to increase protein expressions of antioxidant glutathione peroxidase 1, as well as anti-apoptotic Bcl-2, in skeletal muscle at age 10 weeks.	Hydrogen	14-22	B cell leukemia/lymphoma 2	Mus musculus	129-134
27916457-5	2016	Perturbation of hydrogen bond networks at the hinge of the GluN2A bi-lobe structure affects both zinc inhibition and open probability, supporting the general model in which the bi-lobe motion in ATD regulates the channel activity in NMDA receptors.	Hydrogen	16-24	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	59-65
27933961-2	2016	Crystal structures of prototypical members bound to the ATP-binding site of TNNI3K reveal two anchoring hydrogen bond contacts: (1) from the hinge region amide N-H to the pyrimidine nitrogen and (2) from the sulfonamide N-H to the gatekeeper threonine.	Hydrogen	104-112	TNNI3 interacting kinase	Homo sapiens	76-82
27973440-6	2016	The stability of the representative complex 8 in the water-containing solution as well as its ability to interact with the reduced glutathione, cysteine and bovine serum albumin was also studied using 1H and 31P-NMR spectroscopy (studied in the 50% DMF-d7/50% D2O mixture) and ESI+ mass spectrometry (studied in the 50% DMF/50% H2O mixture); DMF = dimethylformamide.	Hydrogen	201-203	albumin	Homo sapiens	164-177
27783493-5	2016	The finding questions the very existence of partly unfolded intermediates in the SOD1 aggregation process and presents new clues to the mechanism by which hydrogen bonding maintains global structural integrity.	Hydrogen	155-163	superoxide dismutase 1	Homo sapiens	81-85
27926838-5	2016	Here we present a highly detailed structural and energetic map of the entire folding landscape of the leucine-rich repeat protein, pp32 (Anp32), obtained by combining pressure-dependent site-specific 1H-15N HSQC data with coarse-grained molecular dynamics simulations.	Hydrogen	200-202	nyctalopin	Homo sapiens	102-129
27801582-5	2016	Hydrogen bonding plays a dual role; along with hydrophobic interactions, it may disturb the microenvironment of some secondary structures such as the beta-turn type III, while it also triggers structural changes in lipid molecules likely resulting from the extension of CL acyl chains to the hydrophobic channels of cyt c.	Hydrogen	0-8	cytochrome c, somatic	Homo sapiens	316-321
27646345-0	2016	1H NMR To Explore the Metabolome of Exhaled Breath Condensate in alpha1-Antitrypsin Deficient Patients: A Pilot Study.	Hydrogen	0-2	serpin family A member 1	Homo sapiens	65-83
27689626-11	2016	Sodium-hydrogen exchanger 1 (NHE1) protein content was lower 9 h post-HIIE (~0.8-fold) compared with every other postexercise time point, but NHE1 mRNA expression was 2.2 to 2.9-fold greater 24-72 h post-HIIE, compared with the first 24 h post-HIIE.	Hydrogen	7-15	solute carrier family 9 member A1	Homo sapiens	29-33
27140066-9	2016	In the H2 (-) group, IRI was indicated by a higher aspartate aminotransferase (AST), alanine aminotransferase (ALT) leakage, portal resistance, 8-hydroxy-2-deoxyguanosine-positive cell rate, apoptotic index, and endothelial endothelin-1 expression, together with reduced bile production, oxygen consumption, and GSH/GSSG ratio (vs. CT).	Hydrogen	7-9	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	51-77
27140066-9	2016	In the H2 (-) group, IRI was indicated by a higher aspartate aminotransferase (AST), alanine aminotransferase (ALT) leakage, portal resistance, 8-hydroxy-2-deoxyguanosine-positive cell rate, apoptotic index, and endothelial endothelin-1 expression, together with reduced bile production, oxygen consumption, and GSH/GSSG ratio (vs. CT).	Hydrogen	7-9	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	79-82
27140066-9	2016	In the H2 (-) group, IRI was indicated by a higher aspartate aminotransferase (AST), alanine aminotransferase (ALT) leakage, portal resistance, 8-hydroxy-2-deoxyguanosine-positive cell rate, apoptotic index, and endothelial endothelin-1 expression, together with reduced bile production, oxygen consumption, and GSH/GSSG ratio (vs. CT).	Hydrogen	7-9	endothelin 1	Rattus norvegicus	224-236
27768928-8	2016	Furthermore, VPA can increase the protein expression of Snail since 1h treatment via up regulation of half-lives of Snail protein.	Hydrogen	68-70	snail family transcriptional repressor 1	Homo sapiens	56-61
27768928-8	2016	Furthermore, VPA can increase the protein expression of Snail since 1h treatment via up regulation of half-lives of Snail protein.	Hydrogen	68-70	snail family transcriptional repressor 1	Homo sapiens	116-121
27707754-5	2016	RESULTS: In study 1, hs-cTnT, but not hs-cTnI, exhibited a diurnal rhythm, characterized by gradually decreasing concentrations throughout daytime, rising concentrations during nighttime, to peak concentrations in the morning (mean 16.2 ng/L at 8:30 AM and 12.1 ng/L at 7:30 PM).	Hydrogen	21-23	troponin T2, cardiac type	Homo sapiens	24-28
27580908-4	2016	Student cohorts were alternatively given a faculty-supervised 1h session playing a simple interactive digital Tic-tac-toe quiz module on pediatric gastrointestinal radiology or a 1h didactic introductory lecture on the same topic.	Hydrogen	62-64	pleckstrin and Sec7 domain containing 4	Homo sapiens	110-113
27624060-1	2016	The aim of this study is to investigate the effects of molecular hydrogen (H2) and suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on paraquat (PQ)-stimulated production of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-alpha) in macrophages.	Hydrogen	65-73	tumor necrosis factor	Mus musculus	232-259
27624060-1	2016	The aim of this study is to investigate the effects of molecular hydrogen (H2) and suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on paraquat (PQ)-stimulated production of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-alpha) in macrophages.	Hydrogen	65-73	tumor necrosis factor	Mus musculus	261-270
27624060-6	2016	H2 and H2 combined with SAHA evoked a greater reduction in PQ-induced ROS production than SAHA alone, especially at 2 and 8 h. At 1 and 2 h, treatments involving H2 caused a greater decrease in PQ-induced production of TNF-alpha than the corresponding treatments without H2.	Hydrogen	0-2	tumor necrosis factor	Mus musculus	219-228
27624060-6	2016	H2 and H2 combined with SAHA evoked a greater reduction in PQ-induced ROS production than SAHA alone, especially at 2 and 8 h. At 1 and 2 h, treatments involving H2 caused a greater decrease in PQ-induced production of TNF-alpha than the corresponding treatments without H2.	Hydrogen	7-9	tumor necrosis factor	Mus musculus	219-228
27624060-6	2016	H2 and H2 combined with SAHA evoked a greater reduction in PQ-induced ROS production than SAHA alone, especially at 2 and 8 h. At 1 and 2 h, treatments involving H2 caused a greater decrease in PQ-induced production of TNF-alpha than the corresponding treatments without H2.	Hydrogen	7-9	tumor necrosis factor	Mus musculus	219-228
27624060-6	2016	H2 and H2 combined with SAHA evoked a greater reduction in PQ-induced ROS production than SAHA alone, especially at 2 and 8 h. At 1 and 2 h, treatments involving H2 caused a greater decrease in PQ-induced production of TNF-alpha than the corresponding treatments without H2.	Hydrogen	7-9	tumor necrosis factor	Mus musculus	219-228
27624060-8	2016	H2 decreases PQ-induced ROS production and attenuates early PQ-induced TNF-alpha production whereas SAHA reduces the late phase of the PQ-induced TNF-alpha production in macrophages.	Hydrogen	0-2	tumor necrosis factor	Mus musculus	71-80
26618241-5	2016	The docking studies also revealed that Leu305, Val458 for TRbeta, and Asp407 for TRalpha are showing hydrogen bonds with the most active inhibitors.	Hydrogen	101-109	T cell receptor beta locus	Homo sapiens	58-64
27419805-8	2016	Our findings suggested that H2 S exacerbated taurocholate-induced AP by over-activating autophagy via activation of AMPK and subsequently, inhibition of mTOR.	Hydrogen	28-30	mechanistic target of rapamycin kinase	Homo sapiens	153-157
30235507-3	2016	The results showed that the driving force of the interaction between PPT and BSA was hydrogen bond and Van der Waals force.	Hydrogen	85-93	albumin	Homo sapiens	77-80
27596008-9	2016	Hydrogen gas inhalation markedly improved lung endothelial permeability and decreased both MDA content and MPO activity in lung tissue; these changes were associated with decreases in TNF-alpha, IL-1beta, and IL-6 in BALF.	Hydrogen	0-8	interleukin-1 beta	Oryctolagus cuniculus	195-203
27596008-9	2016	Hydrogen gas inhalation markedly improved lung endothelial permeability and decreased both MDA content and MPO activity in lung tissue; these changes were associated with decreases in TNF-alpha, IL-1beta, and IL-6 in BALF.	Hydrogen	0-8	interleukin-6	Oryctolagus cuniculus	209-213
27765851-3	2016	1H NMR spectroscopy showed that vemurafenib decreases the glycolytic activity of BRAF-mutant (WM266.4 and SKMEL28) but not BRAFWT (CHL-1 and D04) human melanoma cells.	Hydrogen	0-2	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	81-85
27631130-7	2016	The phenolic hydroxyl group of niclosamide forms a crucial hydrogen bond with mGluR1/5.	Hydrogen	59-67	glutamate metabotropic receptor 1	Rattus norvegicus	78-84
27908108-2	2016	For binary TrOH   FA adducts, the presence of dual hydrogen-bond linkages gives rise to three low-lying isomers designated (in relative energy order) as INT, EXT1, and EXT2 depending on whether docking of the FA ligand to the TrOH substrate takes place internal or external to the five-membered reaction cleft of tropolone.	Hydrogen	51-59	exostosin glycosyltransferase 2	Homo sapiens	168-172
27639619-4	2016	The results show that selective BACE1 inhibition may be due to the formation of strong electrostatic interactions with Asp32 and Asp228 and a large number of hydrogen bonds, pi-pi and Van der Waals interactions with the amino acid residues located inside the catalytic cavity, which has different volume and shape compared to BACE2 and CTSD.	Hydrogen	158-166	beta-secretase 1	Homo sapiens	32-37
27560280-2	2016	To test the hypothesis that the lack of a hydrogen bond interaction between benzimidazole and benzothiophene derivatives with Lys192 reduces their affinity for CB1 receptors (as we previously reported) and leads to CB2 selectivity, most of the tested compounds do not exhibit hydrogen bond acceptors.	Hydrogen	42-50	cannabinoid receptor 1	Homo sapiens	160-163
27841888-1	2016	The values of the downfield chemical shift of the bridge hydrogen atom were estimated for a series of compounds containing an intramolecular hydrogen bond O-HO, O-HN, O-HHal, N-HO, N-HN, C-HO, C-HN and C-HHal.	Hydrogen	57-65	nuclear receptor subfamily 4 group A member 3	Homo sapiens	193-197
27879664-8	2016	Furthermore, CTB suppressed the phosphorylation of MKK3/6 by targeting the binding sites via formation of hydrogen bonds.	Hydrogen	106-114	mitogen-activated protein kinase kinase 3	Mus musculus	51-55
27909398-0	2016	An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds.	Hydrogen	86-94	TAR DNA binding protein	Homo sapiens	45-51
27874042-4	2016	Hydrogen bonding and non-bonded interaction energies, and hence the free energy of binding, between the thrombin and its aptamer reduce as the applied electric field is shifted from negative to positive values.	Hydrogen	0-8	coagulation factor II, thrombin	Homo sapiens	104-112
27775350-4	2016	Intermolecular hydrogen bonds involving acetamide groups were found to reduce the reactivity in glycosylations: the protection of NHAc as NAc2 dramatically improved the reactivity.	Hydrogen	15-23	NACC family member 2	Homo sapiens	138-142
27791341-3	2016	Here we show that a selective peptide-based inhibitor of canonical NF-kappaB signaling, in which a hydrogen bond in the NBD peptide is synthetically replaced by a non-labile bond, shows an about 10-fold increased potency relative to the original inhibitor.	Hydrogen	99-107	nuclear factor kappa B subunit 1	Homo sapiens	67-76
27714012-7	2016	Moreover we were able to show that water-mediated hydrogen bonds are present between ERG and DNA in our simulations and that those interactions have the potential to achieve sequence recognition outside the GGAA core DNA-sequence.	Hydrogen	50-58	ETS transcription factor ERG	Homo sapiens	85-88
27777004-2	2016	This exercise identified a greatly simplified 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazole scaffold that afforded nanomolar inhibition of both activating peptide and gamma-thrombin mediated PAR4 stimulation, while reducing both molecular weight and the number of hydrogen bond donors/acceptors by ~50%.	Hydrogen	267-275	coagulation factor II, thrombin	Homo sapiens	176-184
27639056-4	2016	When the initial hydrogen partial pressure was 0.5 atm, the methane yield at high ammonia load (7 g NH4+-N L-1) was 41.0% and 22.3% lower than that at low ammonia load (1 g NH4+-N L-1) in mesophilic and thermophilic condition, respectively.	Hydrogen	17-25	immunoglobulin kappa variable 1-16	Homo sapiens	107-110
27495851-0	2016	Mapping insulin non-covalent interactions with natural polysaccharides by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	74-82	insulin	Homo sapiens	8-15
27845408-4	2016	In this paper, a unilateral diffusion model of hydrogen atoms in Pd alloy based on Fick"s second law is proposed to describe the Pd-H reaction process.	Hydrogen	47-55	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	129-133
27495851-3	2016	Here amide hydrogen/deuterium exchange (HDX) mass spectrometry was employed to localize insulin dynamics induced by interactions with three natural polysaccharides, i.e. chitosan (CH), sodium alginate (ALG) and chondroitin sulfate (CS).	Hydrogen	11-19	insulin	Homo sapiens	88-95
27639056-4	2016	When the initial hydrogen partial pressure was 0.5 atm, the methane yield at high ammonia load (7 g NH4+-N L-1) was 41.0% and 22.3% lower than that at low ammonia load (1 g NH4+-N L-1) in mesophilic and thermophilic condition, respectively.	Hydrogen	17-25	immunoglobulin kappa variable 1-16	Homo sapiens	180-183
27639056-8	2016	Furthermore, the thermophilic methanogens at 0.5 atm of hydrogen partial pressure were more tolerant to high ammonia levels (&gt;=5 g NH4+-N L-1), compared with mesophilic methanogens.	Hydrogen	56-64	immunoglobulin kappa variable 1-16	Homo sapiens	141-144
27709206-0	2016	Iron-catalyzed oxidative sp3 carbon-hydrogen bond functionalization of 3,4-dihydro-1,4-benzoxazin-2-ones.	Hydrogen	36-44	Sp3 transcription factor	Homo sapiens	25-28
27705917-5	2016	Using high resolution proton nuclear magnetic resonance spectroscopy (1H NMR) on GBM cell cultures we provide evidence that the expression of well-known EMT activators of the ZEB, TWIST and SNAI families and EMT target genes N-cadherin and VIMENTIN is associated with aberrant choline metabolism.	Hydrogen	70-72	twist family bHLH transcription factor 1	Homo sapiens	180-185
27709206-1	2016	A novel and efficient iron-catalyzed sp3 carbon-hydrogen bond functionalization of benzoxazinone derivatives has been developed.	Hydrogen	48-56	Sp3 transcription factor	Homo sapiens	37-40
27723344-4	2016	In the negatively charged lipids, CYP3A4 was immersed more deeply and was more inclined toward the membrane because of favorable electrostatic and hydrogen bonding interactions between the CYP catalytic domain and lipid polar head groups.	Hydrogen	147-155	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	34-40
27821403-10	2016	CONCLUSIONS: Vitamin D deficiency was associated with increased 6-year change in hs-cTnT levels.	Hydrogen	81-83	troponin T2, cardiac type	Homo sapiens	84-88
27581394-2	2016	The visual sensor consisted of a thin film of H2-sensitive material (MoO3 and Pd catalyst) coated on a flexible plastic sheet that was pressed against the mouse skin directly above the implant.	Hydrogen	46-48	modifier of obesity 3	Mus musculus	69-73
27324424-5	2016	The inhibitory abilities of ILs on catalase activity could be simply described by their hydrophobicity and hydrogen bonding abilities.	Hydrogen	107-115	catalase	Homo sapiens	35-43
27642068-3	2016	Within an unexpectedly polar active site, CutC orients choline through hydrogen bonding with a putative general base, and through close interactions between phenolic and carboxylate oxygen atoms of the protein scaffold and the polarized methyl groups of the trimethylammonium moiety.	Hydrogen	71-79	cutC copper transporter	Homo sapiens	42-46
27369736-7	2016	Detailed structural and computational docking analyses suggest that this difference in binding mode engagement is driven by conformational restraints imposed by the chemical structure of the inhibitors, and may be fortified by an additional hydrogen bond to MAPK13 in the nanomolar inhibitors.	Hydrogen	241-249	mitogen-activated protein kinase 13	Homo sapiens	258-264
27981920-12	2016	RESULTS: More amino acids were involved in hydrogen and hydrophobic bonds in Patchdock and Firedock docking of Amotosalen hydrochloride with CD-61 than Patchdock and Firedock docking of CD-61 with Tirofiban.	Hydrogen	43-51	integrin subunit beta 3	Homo sapiens	141-146
27668885-8	2016	Virtual screening result shows ZINC70450932 as the most promising lead where HDAC1 interacts with residues Asp99, His178, Tyr204, Phe205 and Leu271 forming seven hydrogen bonds.	Hydrogen	162-170	histone deacetylase 1	Homo sapiens	77-82
27792778-1	2016	We study the dynamic propensity of the backbone hydrogen bonds of the protein MDM2 (the natural regulator of the tumor suppressor p53) in order to determine its binding properties.	Hydrogen	48-56	tumor protein p53	Homo sapiens	130-133
27792778-2	2016	This approach is fostered by the observation that certain backbone hydrogen bonds at the p53-binding site exhibit a dynamical propensity in simulations that differs markedly form their state-value (that is, formed/not formed) in the PDB structure of the apo protein.	Hydrogen	67-75	tumor protein p53	Homo sapiens	89-92
28352827-0	2016	Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy.	Hydrogen	0-8	enolase 2	Homo sapiens	23-26
28352827-0	2016	Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy.	Hydrogen	0-8	interleukin 6	Homo sapiens	28-32
28352827-0	2016	Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy.	Hydrogen	0-8	tumor necrosis factor	Homo sapiens	38-47
28352827-10	2016	Hydrogen water lowers serum NSE, IL-6, and TNF-alpha levels in HIE newborns, thereby exerting a protective effect.	Hydrogen	0-8	enolase 2	Homo sapiens	28-31
28352827-10	2016	Hydrogen water lowers serum NSE, IL-6, and TNF-alpha levels in HIE newborns, thereby exerting a protective effect.	Hydrogen	0-8	interleukin 6	Homo sapiens	33-37
28352827-10	2016	Hydrogen water lowers serum NSE, IL-6, and TNF-alpha levels in HIE newborns, thereby exerting a protective effect.	Hydrogen	0-8	tumor necrosis factor	Homo sapiens	43-52
27548075-7	2016	Similarly, H2 S released by PhNCS-COOH (10-300 muM) reduced, in a concentration-dependent manner, antigenic and non-antigenic degranulation and renin release in all mast cell types.	Hydrogen	11-13	renin	Homo sapiens	144-149
27548075-10	2016	CONCLUSION AND IMPLICATIONS: Collectively, our results demonstrate that, by attenuating the phosphorylation of proteins downstream of FcepsilonRI cross-linking on mast cells, H2 S diminishes [Ca+2 ]i availability and thus mast cell degranulation and renin release.	Hydrogen	175-177	renin	Homo sapiens	250-255
27640753-0	2016	Protein Internal Dynamics Associated With Pre-System Glass Transition Temperature Endothermic Events: Investigation of Insulin and Human Growth Hormone by Solid State Hydrogen/Deuterium Exchange.	Hydrogen	167-175	growth hormone 1	Homo sapiens	137-151
27826185-8	2016	Docking studies also showed that the SO2NH2 of 5u and 5s is inserted deep inside the selective pocket of the COX2-active site and formed a hydrogen-bond interaction with His90, Arg513, Phe518, Ser353, Gln192, and Ile517, which was further validated by superimposed docked pose with celecoxib.	Hydrogen	139-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-113
27802652-6	2016	Here we report a more detailed account of GP effects in the H + H2(v = 4, j = 0)   H + H2(v", j") (para-para) reaction rate coefficients for temperatures between 1 muK (8.6 x 10-11 eV) and 100 K (8.6 x 10-3 eV).	Hydrogen	64-66	mitogen-activated protein kinase kinase kinase 12	Homo sapiens	164-167
27802652-6	2016	Here we report a more detailed account of GP effects in the H + H2(v = 4, j = 0)   H + H2(v", j") (para-para) reaction rate coefficients for temperatures between 1 muK (8.6 x 10-11 eV) and 100 K (8.6 x 10-3 eV).	Hydrogen	87-89	mitogen-activated protein kinase kinase kinase 12	Homo sapiens	164-167
27628201-3	2016	Our results reveal a broadly distributed relaxation of hydrogen atom dynamics of rhodopsin on a picosecond-nanosecond time scale, crucial for protein function, as only observed for globular proteins previously.	Hydrogen	55-63	rhodopsin	Homo sapiens	81-90
27690413-5	2016	We present 1H NMR spectra that reveal (NEt4)[MoO(S2)2picolinate] (Mo-pic) is stable in a d6-DMSO solution after heating at 100  C, in air, revealing unprecedented thermal and aerobic stability of the homogeneous electrocatalyst.	Hydrogen	11-13	tetraspanin 5	Homo sapiens	39-43
27320659-4	2016	This paper describes the employment of enzymatic assays, hydrogen/deuterium exchange mass spectrometry (DXMS) and computational chemistry to develop PLA2 inhibitors.	Hydrogen	57-65	phospholipase A2 group VI	Homo sapiens	149-153
27764212-8	2016	The key amino acid residues surfaced via interaction energy, hydrogen bonding and solvent accessible surface area analysis for each cystatin-cathepsin L1 complex influence the mode of binding and thus control the diverse inhibitory affinity of cystatins towards cysteine proteases.	Hydrogen	61-69	cathepsin L	Homo sapiens	141-153
27637085-5	2016	DUOX2 knockdown with short interfering RNA significantly decreased IFN-gamma-induced VEGF-A or HIF-1alpha up-regulation, as did treatment of pancreatic cancer cells with the NADPH oxidase inhibitor diphenylene iodonium, the multifunctional reduced thiol N-acetylcysteine, and the polyethylene glycol-modified form of the hydrogen peroxide detoxifying enzyme catalase.	Hydrogen	321-329	dual oxidase 2	Homo sapiens	0-5
27637085-5	2016	DUOX2 knockdown with short interfering RNA significantly decreased IFN-gamma-induced VEGF-A or HIF-1alpha up-regulation, as did treatment of pancreatic cancer cells with the NADPH oxidase inhibitor diphenylene iodonium, the multifunctional reduced thiol N-acetylcysteine, and the polyethylene glycol-modified form of the hydrogen peroxide detoxifying enzyme catalase.	Hydrogen	321-329	interferon gamma	Homo sapiens	67-76
27703122-2	2016	The sp-C-H...N hydrogen-bonding interaction is strong enough to promote the deliberate cocrystallization of a series of diynes with a series of dipyridines.	Hydrogen	15-23	surfactant protein C	Homo sapiens	4-8
27539818-2	2016	The acidity of the N-H proton and thus the hydrogen-bond strength can be fine-tuned by replacing one of the amino hydrogen atoms by a substituent R, the acidity increasing with increasing electron-withdrawing strength of R, that is, in the order H&lt;COCH3 &lt;COPh&lt;Tosyl&lt;COCF3 .	Hydrogen	43-51	cochlin	Homo sapiens	251-255
28293075-6	2016	In this study we used in silico approach by modeling CYP19A1 protein the strcture was subjected to protein preparation wizard; to add hydrogen and optimize the protonation states of Thr310 and Ser478 and Asp309 residues.	Hydrogen	134-142	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	53-60
27703196-6	2016	In studies designed to understand the degradation process, multiple cellular modifications of redox-sensitive proteins were identified by peptide sequencing with nanoUPLC-ESI-q-TOF tandem mass spectrometry and the oxidative structural changes of Prx2 explored employing hydrogen/deuterium exchange-mass spectrometry (HDX-MS).	Hydrogen	270-278	paired related homeobox 2	Homo sapiens	246-250
27703196-7	2016	We found that hydrogen/deuterium exchange rate increased in C-terminal region of oxidized Prx2, suggesting the exposure of this region to solvent under oxidation.	Hydrogen	14-22	paired related homeobox 2	Homo sapiens	90-94
27695006-2	2016	Computational docking and mutational study indicated that isoquinolinoquinazolinones form hydrogen bonds with the Cys285 and Arg288 residues of PPARgamma.	Hydrogen	90-98	peroxisome proliferator activated receptor gamma	Homo sapiens	144-153
27703122-6	2016	In both cocrystals, a strong nonconventional ethynyl-carbonyl sp-C-H...O hydrogen bond is observed between the components.	Hydrogen	73-81	surfactant protein C	Homo sapiens	62-66
27524310-7	2016	Compounds 1c-1f, 1h effectively inhibited the in vitro kinase activity of EGFR and HER2 with similar efficacy as gefitinib and erlotinib.	Hydrogen	17-19	epidermal growth factor receptor	Homo sapiens	74-78
27524310-7	2016	Compounds 1c-1f, 1h effectively inhibited the in vitro kinase activity of EGFR and HER2 with similar efficacy as gefitinib and erlotinib.	Hydrogen	17-19	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-87
27719672-9	2016	The hydrogen-bonding interaction of the amino-acid residue, Asn-82, of SHBG was also present in displays of DHT and all the three alternate phthalates.	Hydrogen	4-12	sex hormone binding globulin	Homo sapiens	71-75
27578247-1	2016	During the lead generation and optimization of PARP inhibitors blocking centrosome clustering, it was discovered that increasing hydrogen bond acceptor (HBA) strength improved cellular potency but led to elevated Caco2 and MDR1 efflux and thus poor oral bioavailability.	Hydrogen	129-137	ATP binding cassette subfamily B member 1	Homo sapiens	223-227
27406851-6	2016	In addition to growth by fermentation and nitrate reduction, this strain was able to reduce Fe(III), Mn(IV), Co(III) and Cr(VI) when H2 or organic carbon was available as the electron donor, but did not actively reduce oxidized sulfur compounds (e.g. sulfate, thiosulfate or S0).	Hydrogen	133-135	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	95-98
27406851-6	2016	In addition to growth by fermentation and nitrate reduction, this strain was able to reduce Fe(III), Mn(IV), Co(III) and Cr(VI) when H2 or organic carbon was available as the electron donor, but did not actively reduce oxidized sulfur compounds (e.g. sulfate, thiosulfate or S0).	Hydrogen	133-135	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	109-116
29714946-1	2016	This study is aimed to investigate the effects of mechanical stretch on the expression of transforming growth factor-beta1(TGF-beta1)and fibroblast growth factor-2(FGF-2),and the signaling pathway in human bronchial epithelioid(16HBE)cells under mechanical stretch.Using loading device with flexible substrate(FX-4000T)to stretch 16 HBE cells,we found that the stretching elongation was 15%,at frequency of 1Hz,stretching for 0.5h,1h,1.5hand 2h.Choosing the higher expression of TGF-beta1,FGF-2and Ca2+group to carry out intervention experiments,we used the cells pretreated with canonical transient receptor potential 1(TRPC1)channel antagonist SKF96365,protein kinase C(PKC)inhibitor HA-100,and thereafter mechanical stretch to interpose.Compared with those in the blank control group,TGF-beta1and FGF-2"protein and mRNA,intracellular Ca2+fluorescence intensity were higher,and the differences were statistically significant(P&lt;0.05)at the 4time points,0.5h,1h,1.5h and 2h.At 0.5h,the increasing rate was the highest.TGF-beta1protein and mRNA,FGF-2protein and mRNA,intracellular Ca2+luorescence intensity in the stretch+SKF96365and stretch+ HA-100 intervented group were decreased,the differences were statistically significant than those in 0.5hstretch group(P&lt;0.05)without intervention.The expression of TGF-beta1,FGF-2 was up-regulated in 16 HBE cells under mechanical stretch,PKC,TRPC1,and Ca2+may participate in the signal path.	Hydrogen	431-433	transforming growth factor beta 1	Homo sapiens	90-122
29714946-1	2016	This study is aimed to investigate the effects of mechanical stretch on the expression of transforming growth factor-beta1(TGF-beta1)and fibroblast growth factor-2(FGF-2),and the signaling pathway in human bronchial epithelioid(16HBE)cells under mechanical stretch.Using loading device with flexible substrate(FX-4000T)to stretch 16 HBE cells,we found that the stretching elongation was 15%,at frequency of 1Hz,stretching for 0.5h,1h,1.5hand 2h.Choosing the higher expression of TGF-beta1,FGF-2and Ca2+group to carry out intervention experiments,we used the cells pretreated with canonical transient receptor potential 1(TRPC1)channel antagonist SKF96365,protein kinase C(PKC)inhibitor HA-100,and thereafter mechanical stretch to interpose.Compared with those in the blank control group,TGF-beta1and FGF-2"protein and mRNA,intracellular Ca2+fluorescence intensity were higher,and the differences were statistically significant(P&lt;0.05)at the 4time points,0.5h,1h,1.5h and 2h.At 0.5h,the increasing rate was the highest.TGF-beta1protein and mRNA,FGF-2protein and mRNA,intracellular Ca2+luorescence intensity in the stretch+SKF96365and stretch+ HA-100 intervented group were decreased,the differences were statistically significant than those in 0.5hstretch group(P&lt;0.05)without intervention.The expression of TGF-beta1,FGF-2 was up-regulated in 16 HBE cells under mechanical stretch,PKC,TRPC1,and Ca2+may participate in the signal path.	Hydrogen	431-433	transforming growth factor beta 1	Homo sapiens	123-132
29714946-1	2016	This study is aimed to investigate the effects of mechanical stretch on the expression of transforming growth factor-beta1(TGF-beta1)and fibroblast growth factor-2(FGF-2),and the signaling pathway in human bronchial epithelioid(16HBE)cells under mechanical stretch.Using loading device with flexible substrate(FX-4000T)to stretch 16 HBE cells,we found that the stretching elongation was 15%,at frequency of 1Hz,stretching for 0.5h,1h,1.5hand 2h.Choosing the higher expression of TGF-beta1,FGF-2and Ca2+group to carry out intervention experiments,we used the cells pretreated with canonical transient receptor potential 1(TRPC1)channel antagonist SKF96365,protein kinase C(PKC)inhibitor HA-100,and thereafter mechanical stretch to interpose.Compared with those in the blank control group,TGF-beta1and FGF-2"protein and mRNA,intracellular Ca2+fluorescence intensity were higher,and the differences were statistically significant(P&lt;0.05)at the 4time points,0.5h,1h,1.5h and 2h.At 0.5h,the increasing rate was the highest.TGF-beta1protein and mRNA,FGF-2protein and mRNA,intracellular Ca2+luorescence intensity in the stretch+SKF96365and stretch+ HA-100 intervented group were decreased,the differences were statistically significant than those in 0.5hstretch group(P&lt;0.05)without intervention.The expression of TGF-beta1,FGF-2 was up-regulated in 16 HBE cells under mechanical stretch,PKC,TRPC1,and Ca2+may participate in the signal path.	Hydrogen	431-433	fibroblast growth factor 2	Homo sapiens	164-169
27611728-5	2016	In addition, substitution of the hydrogen atom H4 of Phe471 with halogen atoms, in particular the bromine atom Br4, can constitute a geometrically satisfactory halogen bonding with the oxygen atom O of CETP Ile193 residue.	Hydrogen	33-41	cholesteryl ester transfer protein	Homo sapiens	202-206
27318963-8	2016	We suggest that the interactions responsible for the marked response upon shear observed for beta-amyloid peptide monolayers are the hydrogen bonds of the beta-sheet structure that can form an infinite planar network at the interface.	Hydrogen	133-141	amyloid beta precursor protein	Homo sapiens	93-113
27431412-5	2016	The 11beta-HSD1 isoform is predominantly a reductase, which catalyzes nicotinamide adenine dinucleotide phosphate hydrogen-dependent conversion of cortisone/11-DHC to cortisol/corticosterone, and is widely expressed and present at the highest levels in the liver, lungs, adipose tissues, ovaries, and central nervous system.	Hydrogen	114-122	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	4-15
27515282-9	2016	Treatment over 10min and 1h with rhBGNc increased ERK1 phosphorylation, while the SI/R-induced increase in superoxide production was attenuated by rhBGNc.	Hydrogen	25-27	mitogen-activated protein kinase 3	Homo sapiens	50-54
27519650-10	2016	Fourier transform infrared studies confirmed the presence of hydrogen bonding between Eudragit S100 and PEO suggesting this was the principle reason for stabilization of the amorphous CX/PEO solid dispersion system.	Hydrogen	61-69	S100 calcium binding protein A1	Homo sapiens	95-99
27287134-4	2016	Furthermore, in vitro release study specified that free rh insulin solution encapsulated in uncoated gelatine capsule released 97.8% of peptide within 1h in SGF (pH~1.2).	Hydrogen	151-153	insulin	Homo sapiens	59-66
27714024-3	2016	Here we show that the presence of valence sulfide impurities, such as MoS3 and WS3, and their oxide counterparts, such as MoO2, MoO3 and WO2, WO3 can contribute to the catalytic activity towards hydronium reduction to hydrogen of MoS2 and WS2.	Hydrogen	218-226	dynactin subunit 6	Homo sapiens	79-82
27608266-2	2016	Through this treatment, the structures of SPI particles were partly unfolded and adsorbed SSPS mainly via hydrophobic interactions and hydrogen bonding with larger particle sizes.	Hydrogen	135-143	chromogranin A	Homo sapiens	42-45
27654858-6	2016	Based on the intensity ratio of the 1H-15N HSQC spectra of Tbeta4 in the complex with G-actin in the paramagnetic and diamagnetic states, the distances between the amide groups of Tbeta4 and the spin label of G-actin were estimated.	Hydrogen	36-38	thymosin beta 4 X-linked	Homo sapiens	59-65
27600721-0	2016	Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds.	Hydrogen	67-75	tumor protein p53	Homo sapiens	30-33
27722290-8	2016	Due to the presence of a net surface charge on lysozyme, electrostatic interactions in PIL-water systems and salt solutions enhanced lysozyme activity more than the specific hydrogen-bond interactions present in non-ionic molecular solvents.	Hydrogen	174-182	lysozyme	Homo sapiens	47-55
27569420-3	2016	Stoichiometric addition of HCl to the Co(I)-(N2) cleanly affords the Co(III) hydridochloride complex, which, upon the addition of Cp2ZrHCl, evolves hydrogen gas and regenerates the Co(I)-(N2) complex.	Hydrogen	148-156	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	72-75
27722548-3	2016	At 5 K, the ground state is composed of large clusters of hydrogen chemisorbed at sp2 carbon sites, on the edges and in voids of the graphene sheets.	Hydrogen	58-66	Sp2 transcription factor	Homo sapiens	82-85
27560462-3	2016	This Co(II) (H2 O2 ) compound is made observable by incorporating second-sphere hydrogen-bonding interactions between bound H2 O2 and the supporting ligand, a trianionic trisulfonamido ligand.	Hydrogen	80-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	5-11
27722188-1	2016	In this article we present 1H and 13C chemical shift assignments, secondary structural propensity data and normalized temperature coefficient data for N-terminal peptides of Connexin 26 (Cx26), Cx26G12R and Cx32G12R mutants seen in syndromic deafness and Charcot Marie Tooth Disease respectively, published in "Structural Studies of N-Terminal Mutants of Connexin 26 and Connexin 32 Using 1H NMR Spectroscopy" (Y. Batir, T.A.	Hydrogen	389-391	gap junction protein beta 2	Homo sapiens	174-185
27600721-6	2016	Molecular Dynamics (MD) simulations indicated specific regions of structural heterogeneity unique to p53, which may be promoted by elevated incidence of exposed backbone hydrogen bonds (BHBs).	Hydrogen	170-178	tumor protein p53	Homo sapiens	101-104
29638057-9	2016	Molecular docking studies showed that the tested compounds induced good fitting and forming different hydrogen bonds with the amino acid residues at the active sites of COX-2 enzyme.	Hydrogen	102-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	169-174
27743518-5	2016	There are three primary ER binding subpockets, each with different requirements for hydrogen bonding.	Hydrogen	84-92	estrogen receptor 1	Homo sapiens	24-26
27460171-4	2016	Molecular docking and dynamics simulation revealed that (i) hydrogen atom of the oxime group interacts with Asp99 of HDAC1 through a water bridged hydrogen bond and (ii) a hydroxyl group is optimal attached on the para-position of benzene, interacting with Glu203 at the entrance to the active site tunnel.	Hydrogen	60-68	histone deacetylase 1	Homo sapiens	117-122
27460171-4	2016	Molecular docking and dynamics simulation revealed that (i) hydrogen atom of the oxime group interacts with Asp99 of HDAC1 through a water bridged hydrogen bond and (ii) a hydroxyl group is optimal attached on the para-position of benzene, interacting with Glu203 at the entrance to the active site tunnel.	Hydrogen	147-155	histone deacetylase 1	Homo sapiens	117-122
27344261-2	2016	However, the TC/EA IRMS method can produce inaccurate delta(2)HVSMOW-SLAP results when analyzing nitrogen-bearing organic substances owing to the formation of hydrogen cyanide (HCN), leading to non-quantitative conversion of a sample into molecular hydrogen (H2) for IRMS analysis.	Hydrogen	159-167	Src like adaptor	Homo sapiens	69-73
27584156-7	2016	RESULTS: Heritability of 13 uPC and 17 sPC reached statistical significance, with h2 ranging from 38.8% to 78.5% in the former and 30.5% to 84.8% in the latter group.	Hydrogen	82-84	proline rich protein gene cluster	Homo sapiens	39-42
26372107-9	2016	According to the electrochemical and molecular docking results, it can be concluded that the hydrophobic interactions and hydrogen binding are major interactions between BSA and vitamin B1.	Hydrogen	122-130	albumin	Homo sapiens	170-173
26940023-5	2016	Thermodynamic parameters indicated that hydrogen bonds and van der Waals forces were the main forces maintaining the stability of the HSA-NETA/NET complex.	Hydrogen	40-48	albumin	Homo sapiens	134-137
27589781-7	2016	The assay is based on the structure dynamics information probed by hydrogen deuterium exchange mass spectrometry and offers a unique viewpoint to elucidate the mechanism how phytoestrogens and mycoestrogens interact with estrogen receptor.	Hydrogen	67-75	estrogen receptor 1	Homo sapiens	221-238
27489112-1	2016	In the present work we have combined homology modeling, protein-ligand dockings, quantum mechanics/molecular mechanics calculations and molecular dynamics simulations to generate human 5-lipoxygenase (5-LOX):arachidonic acid (AA) complexes consistent with the 5-lipoxygenating activity (which implies hydrogen abstraction at the C7 position).	Hydrogen	301-309	arachidonate 5-lipoxygenase	Homo sapiens	185-199
27583453-8	2016	Notably, the crystal structure of DUSP26-N (C152S) revealed that the N-terminal region of DUSP26-N (C152S) serves a scaffolding role by positioning the surrounding alpha7-alpha8 loop for interaction with the PTP-loop through formation of an extensive hydrogen bond network, which seems to be critical in making the PTP-loop conformation competent for phosphatase activity.	Hydrogen	251-259	dual specificity phosphatase 26	Homo sapiens	34-40
27583453-8	2016	Notably, the crystal structure of DUSP26-N (C152S) revealed that the N-terminal region of DUSP26-N (C152S) serves a scaffolding role by positioning the surrounding alpha7-alpha8 loop for interaction with the PTP-loop through formation of an extensive hydrogen bond network, which seems to be critical in making the PTP-loop conformation competent for phosphatase activity.	Hydrogen	251-259	dual specificity phosphatase 26	Homo sapiens	90-96
27477846-10	2016	CONCLUSIONS: H2has long-lasting antioxidant and anti-aging effects on vascular endothelial cells through the Nrf2 pathway, even after transient exposure to H2.	Hydrogen	13-15	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
27452370-1	2016	X-ray transient absorption spectroscopy (X-TAS) has been used to study the light-induced hydrogen evolution reaction catalyzed by a tetradentate macrocyclic cobalt complex with the formula [LCo(III)Cl2](+) (L = macrocyclic ligand), [Ru(bpy)3](2+) photosensitizer, and an equimolar mixture of sodium ascorbate/ascorbic acid electron donor in pure water.	Hydrogen	89-97	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	194-197
27489112-1	2016	In the present work we have combined homology modeling, protein-ligand dockings, quantum mechanics/molecular mechanics calculations and molecular dynamics simulations to generate human 5-lipoxygenase (5-LOX):arachidonic acid (AA) complexes consistent with the 5-lipoxygenating activity (which implies hydrogen abstraction at the C7 position).	Hydrogen	301-309	arachidonate 5-lipoxygenase	Homo sapiens	201-206
27602288-13	2016	Molecular docking revealed that compounds 13, 5 and 28 exhibited the lowest binding energies of -12.2, -12.0 and -12.0 kcal/mol, respectively, against human AChE, which is modulated by hydrogen bonding, pi-pi stacking and hydrophobic interaction inside the binding pocket.	Hydrogen	185-193	acetylcholinesterase (Cartwright blood group)	Homo sapiens	157-161
27537873-4	2016	Furthermore, the identifications of the binding constant, binding forces, and the number of binding sites demonstrated that 2-MT could spontaneously interact with CAT at one binding site mainly via Van der Waals" forces and hydrogen bonding.	Hydrogen	224-232	catalase	Homo sapiens	163-166
27507430-4	2016	Specifically, two critical hydrogen bonds between thrombin and the ligand were broken at approximately 190 ns when AMBER force field was used and the number of intra-protein backbone hydrogen bonds was higher under PPC than under AMBER.	Hydrogen	27-35	coagulation factor II, thrombin	Homo sapiens	50-58
27507430-4	2016	Specifically, two critical hydrogen bonds between thrombin and the ligand were broken at approximately 190 ns when AMBER force field was used and the number of intra-protein backbone hydrogen bonds was higher under PPC than under AMBER.	Hydrogen	183-191	coagulation factor II, thrombin	Homo sapiens	50-58
27289320-4	2016	The primary structure-activity relationship study and docking results showed that the 1,2,4-triazole moiety of compound IIk played a key role to form integral hydrogen bonds and pi-pi stacking interaction with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4.	Hydrogen	159-167	phosphodiesterase 4B	Homo sapiens	210-215
27480221-3	2016	We present a detailed study of the conformational dynamics, in the presence and absence of bound imatinib, for full-length human c-Src using hydrogen-deuterium exchange and mass spectrometry.	Hydrogen	141-149	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	129-134
27299369-1	2016	Synchrotron-based photoelectron spectroscopy experiments are presented that address a long standing inconsistency in the treatment of the C1s core level of hydrogen terminated (1 0 0) diamond.	Hydrogen	156-164	complement C1s	Homo sapiens	138-141
27299369-3	2016	Additionally, our results indicate that the asymmetry of the hydrogen terminated (1 0 0) diamond C1s core level is an intrinsic aspect of the bulk diamond peak which we have attributed to sub-surface carbon layers.	Hydrogen	61-69	complement C1s	Homo sapiens	97-100
27289320-4	2016	The primary structure-activity relationship study and docking results showed that the 1,2,4-triazole moiety of compound IIk played a key role to form integral hydrogen bonds and pi-pi stacking interaction with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4.	Hydrogen	159-167	phosphodiesterase 4A	Homo sapiens	210-214
30155160-4	2016	Additionally, the loss of hydrogen bonds directly influences the mechanical response of the framework; the elastic moduli and hardnesses decrease by around 25% from E110 = 24.6 GPa and H110 = 1.25 GPa for x = 0, to E110 = 19.0 GPa and H110 = 0.97 GPa for x = 0.48.	Hydrogen	26-34	glycophorin A (MNS blood group)	Homo sapiens	197-200
27298021-10	2016	The Akt inhibitor partially reversed H2 S-induced inhibition of apo(a) and HNF4alpha expression and apo(a) secretion.	Hydrogen	37-39	AKT serine/threonine kinase 1	Homo sapiens	4-7
27298021-10	2016	The Akt inhibitor partially reversed H2 S-induced inhibition of apo(a) and HNF4alpha expression and apo(a) secretion.	Hydrogen	37-39	hepatocyte nuclear factor 4 alpha	Homo sapiens	75-84
30155147-2	2016	Chemical reduction of 1H[B(ArF)4] with KC8 affords selectively the green, room-temperature stable mixed-valent disilicon(0,I) hydride Si2(H)(Idipp)2 (1H), in which the highly reactive Si2H molecule is trapped between two N-heterocyclic carbenes (NHCs).	Hydrogen	22-24	ADP ribosylation factor 4	Homo sapiens	27-32
30155147-2	2016	Chemical reduction of 1H[B(ArF)4] with KC8 affords selectively the green, room-temperature stable mixed-valent disilicon(0,I) hydride Si2(H)(Idipp)2 (1H), in which the highly reactive Si2H molecule is trapped between two N-heterocyclic carbenes (NHCs).	Hydrogen	150-152	ADP ribosylation factor 4	Homo sapiens	27-32
30155160-4	2016	Additionally, the loss of hydrogen bonds directly influences the mechanical response of the framework; the elastic moduli and hardnesses decrease by around 25% from E110 = 24.6 GPa and H110 = 1.25 GPa for x = 0, to E110 = 19.0 GPa and H110 = 0.97 GPa for x = 0.48.	Hydrogen	26-34	glycophorin A (MNS blood group)	Homo sapiens	177-180
26715131-12	2016	Through structural modelling of AVPR2, we suggest that disruption of a hydrogen bond between residues Thr269 and Arg137 may promote stabilization of the receptor in its active conformation.	Hydrogen	71-79	arginine vasopressin receptor 2	Homo sapiens	32-37
30155160-4	2016	Additionally, the loss of hydrogen bonds directly influences the mechanical response of the framework; the elastic moduli and hardnesses decrease by around 25% from E110 = 24.6 GPa and H110 = 1.25 GPa for x = 0, to E110 = 19.0 GPa and H110 = 0.97 GPa for x = 0.48.	Hydrogen	26-34	glycophorin A (MNS blood group)	Homo sapiens	197-200
30155160-4	2016	Additionally, the loss of hydrogen bonds directly influences the mechanical response of the framework; the elastic moduli and hardnesses decrease by around 25% from E110 = 24.6 GPa and H110 = 1.25 GPa for x = 0, to E110 = 19.0 GPa and H110 = 0.97 GPa for x = 0.48.	Hydrogen	26-34	glycophorin A (MNS blood group)	Homo sapiens	197-200
27454315-13	2016	CONCLUSION: Extraction of uremic toxins, primarily phosphate and hydrogen ions, dramatically increases the ALP activity under physiological conditions.	Hydrogen	65-73	alkaline phosphatase, placental	Homo sapiens	107-110
27017351-7	2016	Pyranyl ring oxygen in compound 9a forms two hydrogen bonds with HIS353 and HIS513 residues in the active site of the ACE having good G score ([Formula: see text]) of this compound, comparable to that of the reference drug captopril ([Formula: see text]).	Hydrogen	45-53	angiotensin I converting enzyme	Homo sapiens	118-121
27434555-8	2016	The cytotoxicity, the levels of ONOO(-) and 8-OHdG, and PAR expression in HG+H2 group were significantly lower than those of the HG group (all P &lt; 0.01).	Hydrogen	77-79	plasminogen activator, urokinase receptor	Rattus norvegicus	56-59
27252381-5	2016	Using hydrogen-deuterium exchange NMR and fluorescence quenching techniques, we demonstrate that Abeta phosphorylation at serine 8 causes structural changes in the N-terminal region of Abeta aggregates in favor of less compact conformations.	Hydrogen	6-14	amyloid beta precursor protein	Homo sapiens	97-102
27252381-5	2016	Using hydrogen-deuterium exchange NMR and fluorescence quenching techniques, we demonstrate that Abeta phosphorylation at serine 8 causes structural changes in the N-terminal region of Abeta aggregates in favor of less compact conformations.	Hydrogen	6-14	amyloid beta precursor protein	Homo sapiens	185-190
27109758-9	2016	These findings were supported by molecular docking results, which suggested that pinostrobin forms hydrogen bonds with residues His48 and Asp49 of PLA2, besides, a pi-pi stacking interactions with those of residues Phe5 and Trp31, and rings C of flavanone and Tyr52 of the toxin.	Hydrogen	99-107	phospholipase A2, group V	Mus musculus	147-151
27082063-4	2016	Here, we use hydrogen/deuterium exchange-mass spectrometry (HDX-MS) to examine Cby"s C-terminal half.	Hydrogen	13-21	chibby family member 1, beta catenin antagonist	Homo sapiens	79-82
27400859-0	2016	Composition and Interface Engineering of Alloyed MoS2 x Se2(1- x ) Nanotubes for Enhanced Hydrogen Evolution Reaction Activity.	Hydrogen	90-98	fucosyltransferase 2	Homo sapiens	56-59
27400859-1	2016	Hierarchical MoS2 x Se2(1- x ) nanotubes assembled from several-layered nanosheets featuring tunable chalcogen compositions, expanded interlayer spacing and carbon modification, are synthesized for enhanced electrocatalytic hydrogen evolution reaction (HER).	Hydrogen	224-232	fucosyltransferase 2	Homo sapiens	20-23
27329786-5	2016	De novo design efforts of a novel scaffold derived from SCH772984 by employing hydrogen bond interactions specific for ERK in the binding pocket identified 1-(1H-pyrazolo[4,3-c]pyridin-6-yl)ureas as a viable lead series.	Hydrogen	79-87	mitogen-activated protein kinase 1	Homo sapiens	119-122
27244216-3	2016	Herein, we describe the design of a novel symmetrical membrane reactor with a sandwich-like structure, whereby a largescale production (&gt;10 mL min(-1)  cm(-2) ) of hydrogen and syngas can be obtained simultaneously on opposite sides of the OTM.	Hydrogen	167-175	CD59 molecule (CD59 blood group)	Homo sapiens	146-152
26794254-3	2016	Patient triage according to the predefined hs-cTnT 0-hour/1-hour algorithm (hs-cTnT below 12 ng/L and Delta1 hour below 3 ng/L to rule out; hs-cTnT at least 52 ng/L or Delta1 hour at least 5 ng/L to rule in; remaining patients to the "observational zone") was compared against a centrally adjudicated final diagnosis by 2 independent cardiologists (reference standard).	Hydrogen	43-45	troponin T2, cardiac type	Homo sapiens	46-50
27300721-2	2016	We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2.	Hydrogen	194-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
27300721-2	2016	We report that a combination of variable scan rate cyclic voltammetry and foot-of-the-wave analysis (FOWA) can be used to detect transient Co(III)H and Co(II)H intermediates of electrocatalytic H2 production by [Co(II)(P(tBu)2N(Ph)2)(CH3CN)3](2+) and Co(II)(dmgBF2)2(CH3CN)2.	Hydrogen	194-196	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	212-218
27300721-5	2016	A bridge-protonated Co(I) species was ruled out as a catalytic intermediate for Co(II)(dmgBF2)2(CH3CN)2 from voltammograms recorded at 1000 psi of H2.	Hydrogen	147-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-86
27384580-8	2016	CCR2 expression was "likely greater" at IP (84.9% likelihood effect), "likely greater" at 1H (87.7% likelihood effect), "very likely greater" at 2H (97.0% likelihood effect), and "likely greater" at 5H (90.1% likelihood effect) in SUPP, compared to PL.	Hydrogen	90-92	C-C motif chemokine receptor 2	Homo sapiens	0-4
27184766-4	2016	Molecular docking was further performed to study the inhibitor-c-Met kinase interactions, and the results show that compound 4j was potently bound to the c-Met kinase with three hydrogen bonds.	Hydrogen	178-186	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	154-159
26794254-6	2016	Applying the hs-cTnT 0-hour/1-hour algorithm, 813 (63.4%) patients were classified as rule out, 184 (14.4%) were classified as rule in, and 285 (22.2%) were triaged to the observational zone.	Hydrogen	13-15	troponin T2, cardiac type	Homo sapiens	16-20
27264884-2	2016	Therefore, the purpose of this study was to test the hypothesis that an acute 1h bout of hyperthermic treatment improves glucose, insulin, and leptin responses to an oral glucose challenge (OGTT) in obese type 2 diabetics and healthy humans.	Hydrogen	78-80	insulin	Homo sapiens	130-137
27243608-6	2016	By using the N-doped multilayer composites, high hydrogen generation specific rate of 5560 mL min(-1) gCo(-1) was achieved at room temperature.	Hydrogen	49-57	CD59 molecule (CD59 blood group)	Homo sapiens	94-100
26091790-0	2016	Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-kappaB Pathway and NLRP3 Inflammasome.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	175-180
26851769-5	2016	NAC 50mg/kg/d administered 1h after initiation of hypothermia significantly decreased iNOS expression and caspase 3 activation in the injured hemisphere versus hypothermia alone.	Hydrogen	27-29	nitric oxide synthase 2	Rattus norvegicus	86-90
27248478-6	2016	Further analysis shows that the nonadditive effects are partly due to variations in the strength of a hydrogen-bond between the X = NH3(+) ligands family and thrombin residue Gly216.	Hydrogen	102-110	coagulation factor II, thrombin	Homo sapiens	158-166
27167594-1	2016	Under H2 pressure, Co(II)(dmgBF2)2L2 (L = H2O, THF) generates a low concentration of an H  donor.	Hydrogen	6-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-36
27334175-3	2016	The diffusion coefficient of hydrogen reached a maximum value around 10 GPa.	Hydrogen	29-37	glycophorin A (MNS blood group)	Homo sapiens	72-75
27296782-3	2016	The carbonaceous reforming reactions include conversion of CHx (x = 0, 1, 2 and 3) species by hydrogen molecules (H2) to form CHx+2 species or oxidation of C atoms by oxygen molecules to form CO2.	Hydrogen	94-102	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	64-81
27187840-5	2016	Hydrogen, usually inapplicable during InN growth due to formation of metallic indium, and silane are needed to enhance the aspect ratio and to reduce parasitic deposition beside the nanorods on the sapphire surface.	Hydrogen	0-8	growth hormone releasing hormone	Homo sapiens	38-41
27221513-0	2016	NMR detection in biofluid extracts at sub-muM concentrations via para-H2 induced hyperpolarization.	Hydrogen	70-72	latexin	Homo sapiens	42-45
27049867-6	2016	The thermodynamic parameters DeltaH and DeltaS of the DFDPT-CYP3A4 complex were negative, which indicated that their interaction was driven mainly by hydrogen bonding and van der Waals force.	Hydrogen	150-158	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	60-66
27049867-11	2016	The results indicated that DFDPT interacted with a panel of amino acids in the active sites of CYP3A4 protein mainly through formation of hydrogen bond.	Hydrogen	138-146	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	95-101
27155156-6	2016	One of these patients showed a novel heteroplasmic mitochondrial mutation m.3861A &gt; C (W185C) which lead to a loss of stability of the ND1 protein since it created a new hydrogen bund between the unique created cystein C185 and the A182 residue.	Hydrogen	173-181	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	138-141
27391733-1	2016	We use fast transient transmission and emission spectroscopies in the pulse laser heated diamond anvil cell to probe the energy-dependent optical properties of hydrogen at pressures of 10-150 GPa and temperatures up to 6000 K. Hydrogen is absorptive at visible to near-infrared wavelengths above a threshold temperature that decreases from 3000 K at 18 GPa to 1700 K at 110 GPa.	Hydrogen	160-168	glycophorin A (MNS blood group)	Homo sapiens	192-195
27391733-1	2016	We use fast transient transmission and emission spectroscopies in the pulse laser heated diamond anvil cell to probe the energy-dependent optical properties of hydrogen at pressures of 10-150 GPa and temperatures up to 6000 K. Hydrogen is absorptive at visible to near-infrared wavelengths above a threshold temperature that decreases from 3000 K at 18 GPa to 1700 K at 110 GPa.	Hydrogen	227-235	glycophorin A (MNS blood group)	Homo sapiens	192-195
27391733-1	2016	We use fast transient transmission and emission spectroscopies in the pulse laser heated diamond anvil cell to probe the energy-dependent optical properties of hydrogen at pressures of 10-150 GPa and temperatures up to 6000 K. Hydrogen is absorptive at visible to near-infrared wavelengths above a threshold temperature that decreases from 3000 K at 18 GPa to 1700 K at 110 GPa.	Hydrogen	227-235	glycophorin A (MNS blood group)	Homo sapiens	353-356
27391733-1	2016	We use fast transient transmission and emission spectroscopies in the pulse laser heated diamond anvil cell to probe the energy-dependent optical properties of hydrogen at pressures of 10-150 GPa and temperatures up to 6000 K. Hydrogen is absorptive at visible to near-infrared wavelengths above a threshold temperature that decreases from 3000 K at 18 GPa to 1700 K at 110 GPa.	Hydrogen	227-235	glycophorin A (MNS blood group)	Homo sapiens	353-356
27391733-2	2016	Transmission spectra at 2400 K and 141 GPa indicate that the absorptive hydrogen is semiconducting or semimetallic in character, definitively ruling out a first-order insulator-metal transition in the studied pressure range.	Hydrogen	72-80	glycophorin A (MNS blood group)	Homo sapiens	39-42
27173110-0	2016	Use of deuterium labeling by high-temperature solid-state hydrogen-exchange reaction for mass spectrometric analysis of bradykinin biotransformation.	Hydrogen	58-66	kininogen 1	Homo sapiens	120-130
29123834-3	2017	In this study, we investigated the protective efficacies of inhaled hydrogen against lipopolysaccharide (LPS)-induced ileus.	Hydrogen	68-76	toll-like receptor 4	Mus musculus	105-108
29123834-7	2017	Hydrogen (1.3%) was inhaled for 25 h beginning at 1 h prior to LPS treatment.	Hydrogen	0-8	toll-like receptor 4	Mus musculus	63-66
29123834-10	2017	Hydrogen significantly prevented LPS-induced bowel dysmotility and reduced leukocyte extravasation, as well as inhibition of inflammatory cytokine expression.	Hydrogen	0-8	toll-like receptor 4	Mus musculus	33-36
29123834-11	2017	In vitro analysis of cytokine levels after LPS treatment of cultured macrophages showed an increase of interleukin-10 by hydrogen regardless of the presence of nitric oxide.	Hydrogen	121-129	toll-like receptor 4	Mus musculus	43-46
29123834-12	2017	Conclusions: This study showed the protective effects of hydrogen inhalation on LPS-induced septic ileus through inhibition of inflammation in the muscularis propria.	Hydrogen	57-65	toll-like receptor 4	Mus musculus	80-83
27171348-7	2016	Rooting-related enzymes, peroxidase, polyphenol oxidase, indoleacetic acid oxidase were required for H2-induced adventitious root.	Hydrogen	101-103	peroxidase 2-like	Cucumis sativus	25-35
28955897-5	2016	The increased binding affinity may be due to the formation of more hydrogen bonds upon binding CaM for the Trp analogue with more nitrogen atoms.	Hydrogen	67-75	calmodulin 1	Homo sapiens	95-98
26994895-10	2016	Taken together, our results highlight the importance of the Arg347-Leu333-Asp345 hydrogen-bonds network in the catalysis of AADC and reveal the molecular basis for the pathogenicity of the variants R347.	Hydrogen	81-89	dopa decarboxylase	Homo sapiens	124-128
26784277-10	2016	When collapsed across groups, TNF-alpha was significantly increased at IP, 30P, 1H, and 2H (P values &lt; 0.05), whereas MCP-1 was significantly elevated at all postexercise time points (P values &lt; 0.05).	Hydrogen	80-82	tumor necrosis factor	Homo sapiens	30-39
27427607-7	2016	It was found that both GRs and fiber contributed to the hydrogen generation rate of Co/GRs-PANFs (3222 mL x min(-1) x g(-1)), which is much higher than that of cobalt powders (915 mL x min(-1) x g(-1)) and Co/GRs (995 mL x min(-1) x g(-1)).	Hydrogen	56-64	CD59 molecule (CD59 blood group)	Homo sapiens	108-114
27131098-5	2016	Fluorescence spectroscopy confirmed that TNC displayed a strong capability to quench the fluorescence of HSA, and the acting forces for binding were hydrogen bonds and van der Waals forces.	Hydrogen	149-157	albumin	Homo sapiens	105-108
27188725-9	2016	The electrostatic potential surface (ESP) of the transition state illustrates that hydrogen bonds are generated when [BF4](-) is close to [aEMMIM](+), and SN1 decomposition is much favorable than SN2 decomposition.	Hydrogen	83-91	solute carrier family 38 member 3	Homo sapiens	155-158
27005882-3	2016	Because Ala289 plays a crucial role in maintaining the structure of the polymerization site of hole "a" via a hydrogen bond, it is speculated that the gamma 289Ala   Val substitution can change not only the fibrinogen structure, but also the function of polymerization.	Hydrogen	110-118	fibrinogen beta chain	Homo sapiens	207-217
26784277-11	2016	CCR2 expression on CD14 monocytes was significantly lower at IP, 1H, 2H, and 5H (P values &lt; 0.05).	Hydrogen	65-67	C-C motif chemokine receptor 2	Homo sapiens	0-4
27140653-8	2016	Computational modeling of the AR-NADP(+)-emodin ternary complex indicated that the 3-hydroxy group of emodin plays an essential role by interacting with Ser302 through hydrogen bonding in the specificity pocket of AR.	Hydrogen	168-176	aldo-keto reductase family 1 member B	Homo sapiens	30-32
27262804-5	2016	IL6, Caspase3, Bax1, P-JAK2, P-Stat3 and P-p38 expression was much higher than the control, and was notably decreasedby the application of 100mumol/L hydrogen.	Hydrogen	150-158	interleukin 6	Homo sapiens	0-3
27262804-5	2016	IL6, Caspase3, Bax1, P-JAK2, P-Stat3 and P-p38 expression was much higher than the control, and was notably decreasedby the application of 100mumol/L hydrogen.	Hydrogen	150-158	caspase 3	Homo sapiens	5-13
27262804-6	2016	Bcl2 expression in HDCP group was notably lower than the control and was increased by 100 mumol/L hydrogen.	Hydrogen	98-106	BCL2 apoptosis regulator	Homo sapiens	0-4
27156533-8	2016	GLTSK and GEGSGA interacted with the catalytic site of renin, the angiotensin-I converting enzyme, and the AngII receptor, mainly through hydrogen bonds, polar, hydrophobic and cation-pi interactions according to molecular docking.	Hydrogen	138-146	renin	Homo sapiens	55-60
27114072-1	2016	The reaction of Fe(eta-C5H4NHC(O)PPh2)2 () with PtX2(PPh3)2 selectively formed cage-shaped complexes formulated as [(PtX)4()6]X4 CHCl3 (X = Cl, Br), in which the four square-planar Pt fragments were situated at each vertex and the six s were located in each side of a tetrahedral framework and hydrogen bonds existed between the NH groups in s and X(-) ions inside the cage.	Hydrogen	294-302	paired like homeodomain 2	Homo sapiens	48-52
27145229-8	2016	Density functional theory calculations determined that the radical, after abstracting the C10 hydrogen atom from 5,15-diHPETE, had an energy 5.4 kJ/mol lower than that of the same radical generated from AA, demonstrating the facility of 5,15-diHPETE to form lipoxins.	Hydrogen	94-102	homeobox C10	Homo sapiens	90-93
27010347-7	2016	The results indicate the importance of NOS and NR enzymes, which might be responsible for NO production in explants during H2-induced root organogenesis.	Hydrogen	123-125	nitrate reductase [NADH]-like	Cucumis sativus	47-49
27112430-5	2016	Using established NMR methods, we have previously characterized and measured the strengths of intermolecular hydrogen-bond complexes involving the fluorine moieties CH2 F, CHF2 , and CF3 , and have compared them with the well-known hydrogen-bond complex formed between acetophenone and the strong hydrogen-bond donor p-fluorophenol.	Hydrogen	109-117	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	172-176
27112430-5	2016	Using established NMR methods, we have previously characterized and measured the strengths of intermolecular hydrogen-bond complexes involving the fluorine moieties CH2 F, CHF2 , and CF3 , and have compared them with the well-known hydrogen-bond complex formed between acetophenone and the strong hydrogen-bond donor p-fluorophenol.	Hydrogen	232-240	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	172-176
27112430-5	2016	Using established NMR methods, we have previously characterized and measured the strengths of intermolecular hydrogen-bond complexes involving the fluorine moieties CH2 F, CHF2 , and CF3 , and have compared them with the well-known hydrogen-bond complex formed between acetophenone and the strong hydrogen-bond donor p-fluorophenol.	Hydrogen	232-240	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	172-176
27156533-8	2016	GLTSK and GEGSGA interacted with the catalytic site of renin, the angiotensin-I converting enzyme, and the AngII receptor, mainly through hydrogen bonds, polar, hydrophobic and cation-pi interactions according to molecular docking.	Hydrogen	138-146	angiotensinogen	Homo sapiens	107-112
26987811-5	2016	We found that two docking hydrogen bond (HB)-forming residues on the second extracellular domain (E2) of Cx26 and their equivalent residues are well conserved within docking-compatible connexins, but different between docking-incompatible connexins.	Hydrogen	26-34	gap junction protein beta 2	Homo sapiens	105-109
27229103-0	2016	Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs.	Hydrogen	11-19	aquaporin 1 (Colton blood group)	Homo sapiens	35-46
26994210-6	2016	Chemical cross-linking and NMR-detected hydrogen-deuterium exchange experiments revealed a shift in the populations of small Abeta(1-40) oligomers towards the monomeric species, which we investigated in the present study as being the main process of prevention of Abeta fibril formation by cyclophilins.	Hydrogen	40-48	amyloid beta precursor protein	Homo sapiens	125-130
27347307-6	2016	The enhanced HPSE next released HS-bonded latent TGF-beta from myofibroblast ECM by cleaving HS chains to promote the initiation and progression of BOS.	Hydrogen	32-34	heparanase	Mus musculus	13-17
27065061-7	2016	Using hydrogen-deuterium exchange, we determined that EZ-482 binds to the C-terminal domains of both apoE3 and apoE4.	Hydrogen	6-14	apolipoprotein E	Homo sapiens	101-106
26901099-0	2016	L-Cysteine enhances nutrient absorption via a cystathionine-beta-synthase-derived H2 S pathway in rodent jejunum.	Hydrogen	82-84	cystathionine beta synthase	Rattus norvegicus	46-73
26975658-3	2016	Nuclear magnetic resonance (NMR) spectroscopy with hydrogen-deuterium exchange (HDX) reveals the presence of persistent imino proton signals corresponding to the central G-quartet during topological conversion of Tel23 and Tel25 G4s from hybrid to parallel forms, implying that the transition pathway mainly involves local rearrangements.	Hydrogen	51-59	ETS variant transcription factor 6	Homo sapiens	213-216
26971388-4	2016	When heated, 2 was transformed to the complex Os3 (CO)9 (mu-H)(mu3 -3,4,8-mu3 -7,11,12-C2 B10 H8 )Os3 (CO)9 (mu-H) (3) by a novel opening of the carborane cage with loss of H2 .	Hydrogen	173-175	asporin	Homo sapiens	46-49
26971388-4	2016	When heated, 2 was transformed to the complex Os3 (CO)9 (mu-H)(mu3 -3,4,8-mu3 -7,11,12-C2 B10 H8 )Os3 (CO)9 (mu-H) (3) by a novel opening of the carborane cage with loss of H2 .	Hydrogen	173-175	asporin	Homo sapiens	98-101
26901099-1	2016	Hydrogen sulphide (H2 S) is generated endogenously from L-cysteine (L-Cys) by the enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen	19-21	cystathionine beta synthase	Rattus norvegicus	90-117
28721265-8	2016	As a transcription pathway, the PPARalpha signaling pathway was identified to upregulate their genes by ingesting H2.	Hydrogen	114-116	peroxisome proliferator activated receptor alpha	Mus musculus	32-41
26921388-1	2016	Replacement of hydrogen with fluorine is a useful drug design strategy when decreases in cytochrome P450 (P450) metabolic lability are needed.	Hydrogen	15-23	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-104
26775610-7	2016	The structure of spider monkey cytochrome c indicates that the Y46F substitution destabilizes the heme crevice by disrupting an extensive hydrogen bond network that connects three surface loops including Omega-loop D (residues 70-85), which contains the Met80 heme ligand.	Hydrogen	138-146	cytochrome c, somatic	Homo sapiens	31-43
27122108-7	2016	Three residues on the surface of CD8alpha connecting cavities that formed most of the hydrogen bonds with p/MHC I were also completely conserved.	Hydrogen	86-94	CD8a molecule	Bos taurus	33-41
26775610-0	2016	Disruption of a hydrogen bond network in human versus spider monkey cytochrome c affects heme crevice stability.	Hydrogen	16-24	cytochrome c, somatic	Homo sapiens	68-80
26813142-1	2016	BACKGROUND: Hydrogen sulfide (H2 S) is endogenously generated from L-cysteine (L-Cys) by the enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-Lyase (CSE).	Hydrogen	30-32	cystathionine beta synthase	Rattus norvegicus	101-128
27005483-7	2016	It is believed that the in situ formation of the active species of NaMgF3, NaF and Fe during the heating process could enhance the hydrogen storage properties of MgH2, due to the catalytic effects of these new species.	Hydrogen	131-139	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
28721265-12	2016	H2 induces expression of the PGC-1alpha gene, followed by stimulation of the PPARalpha pathway that regulates FGF21, and the fatty acid and steroid metabolism.	Hydrogen	0-2	peroxisome proliferator activated receptor alpha	Mus musculus	77-86
26893378-7	2016	We next identify two pairs of intramolecular hydrogen bonds that, based on existing x-ray structures, are predicted to form between the most C-terminal beta-barrel domain and the catalytic core domain of tTG.	Hydrogen	45-53	transglutaminase 2	Homo sapiens	204-207
26893378-8	2016	By disrupting these hydrogen bonds, we are able to generate forms of tTG that constitutively assume an open conformation and induce apoptosis.	Hydrogen	20-28	transglutaminase 2	Homo sapiens	69-72
28660022-4	2016	In the solid state, TK6+ hosts two bromide ions in its central cavity by forming six Csp2 -H hydrogen bonds.	Hydrogen	93-101	regulator of calcineurin 2	Homo sapiens	85-89
27308023-8	2016	In contrast, in (2) the packing is dominated by R 2 (2)(24) hydrogen bonds, involving the acidic sp H atom and the oxo O atom, which link the mol-ecules into centrosymmetric dimers.	Hydrogen	60-68	surfactant associated 3	Homo sapiens	97-101
26985580-5	2016	The cognate substrates 6-aminopurines (inosine and guanosine) interact with PNP through extensive hydrogen bonding, but the substrate specificity is found to be a direct result of the electrostatic preorganization energy along the reaction coordinate.	Hydrogen	98-106	purine nucleoside phosphorylase	Homo sapiens	76-79
26493687-2	2016	Conformational changes upon the formation of a covalent cysteinyl flavin adduct are propagated through hydrogen-bonding networks in the core of designed hybrid phototropin LOV2 domains that incorporate the Bcl homology region 3 (BH3) of the key pro-apoptotic protein BH3-interacting-domain death agonist (BID).	Hydrogen	103-111	BH3 interacting domain death agonist	Homo sapiens	305-308
26918937-5	2016	Our results strongly indicate that hydrogen abstraction from C13 in 15-LOX-2 is only consistent with the "tail-first" orientation of AA, with its carboxylate group interacting with Arg429, and that only the pro-S H13 hydrogen will be abstracted (being the pro-R H13 and H10 too far from the acceptor oxygen atom).	Hydrogen	35-43	arachidonate 15-lipoxygenase	Homo sapiens	68-74
26918937-5	2016	Our results strongly indicate that hydrogen abstraction from C13 in 15-LOX-2 is only consistent with the "tail-first" orientation of AA, with its carboxylate group interacting with Arg429, and that only the pro-S H13 hydrogen will be abstracted (being the pro-R H13 and H10 too far from the acceptor oxygen atom).	Hydrogen	217-225	arachidonate 15-lipoxygenase	Homo sapiens	68-74
26966231-1	2016	Previous hydrogen exchange (HX) studies of the spontaneous reversible unfolding of Cytochrome c (Cyt c) under native conditions have led to the following conclusions.	Hydrogen	9-17	cytochrome c, somatic	Homo sapiens	83-95
26975834-2	2016	Here, for the first time, we show that the coupling of hydrogen adsorption and absorption could trigger giant reversible strain in bulk nanoporous Pd (np-Pd) in a weakly adsorbed NaF electrolyte.	Hydrogen	55-63	C-X-C motif chemokine ligand 8	Homo sapiens	179-182
27150684-3	2016	METHODS: This prospective observational study enrolled consecutive patients presenting to the emergency department (ED) with chest pain, for whom hs-cTnT testing was ordered at presentation.	Hydrogen	146-148	troponin T2, cardiac type	Homo sapiens	149-153
26966231-1	2016	Previous hydrogen exchange (HX) studies of the spontaneous reversible unfolding of Cytochrome c (Cyt c) under native conditions have led to the following conclusions.	Hydrogen	9-17	cytochrome c, somatic	Homo sapiens	97-102
26814703-5	2016	Hydrogen bonds between CL-20 and deprotonated LHA were analyzed applying the atoms in molecules (AIM) theory.	Hydrogen	0-8	epithelial membrane protein 1	Homo sapiens	23-28
26280529-0	2016	Sequence-specific 1H, 15N, and 13C resonance assignments of the autophagy-related protein LC3C.	Hydrogen	18-20	microtubule associated protein 1 light chain 3 gamma	Homo sapiens	90-94
26386961-0	2016	15N, 13C and 1H backbone resonance assignments of an artificially engineered TEM-1/PSE-4 class A beta-lactamase chimera and its deconvoluted mutant.	Hydrogen	13-15	amyloid beta precursor protein	Homo sapiens	95-101
26732902-0	2016	Backbone 1H, 15N, 13C NMR assignment of the 518-627 fragment of the androgen receptor encompassing N-terminal and DNA binding domains.	Hydrogen	9-11	androgen receptor	Homo sapiens	68-85
26944614-4	2016	Docking analysis showed that compound 42 could form three hydrogen bonds with c-Met.	Hydrogen	58-66	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	78-83
26969680-7	2016	Retrospective structural analysis indicates the ligand-induced movement of Tyr455(PARP-2) disrupts the intra-molecule hydrogen bonding network, which partially accounts for the "high-energy" protein conformation in the presence of NMS-P118.	Hydrogen	118-126	poly(ADP-ribose) polymerase 2	Homo sapiens	82-88
25536392-3	2016	MATERIALS AND METHODS: During a 4-month prospective observational cohort study, laboratory-based hs-cTnT and POCT cTn were measured simultaneously in 261 undifferentiated chest-pain patients presenting to the emergency department (ED) of the Medical Centre Leeuwarden to determine the diagnostic accuracy of both assays in predicting acute myocardial infarction (AMI) at presentation.	Hydrogen	97-99	troponin T2, cardiac type	Homo sapiens	100-104
26756197-3	2016	In this article, we describe an application of hydrogen deuterium exchange mass spectrometry (HDX-MS) to identify dynamic regions within type III phosphatidylinositol 4 kinase beta (PI4KIIIbeta) in complex with the GTPase Rab11.	Hydrogen	47-55	phosphatidylinositol 4-kinase beta	Homo sapiens	137-180
26537817-2	2016	The aim of this work was to investigate the effect of treatment with hydrogen molecule on the development of disease in mutant SOD1 G93A transgenic mouse model of ALS.	Hydrogen	69-77	superoxide dismutase 1, soluble	Mus musculus	127-131
26756197-3	2016	In this article, we describe an application of hydrogen deuterium exchange mass spectrometry (HDX-MS) to identify dynamic regions within type III phosphatidylinositol 4 kinase beta (PI4KIIIbeta) in complex with the GTPase Rab11.	Hydrogen	47-55	phosphatidylinositol 4-kinase beta	Homo sapiens	182-193
26786101-5	2016	A network of AQP4 loop D hydrogen bonding interactions, identified using molecular dynamics simulations and based on a comparative mutagenic analysis of AQPs 1, 3, and 4, suggest that loop D interactions may provide a general structural framework for tetrameric assembly within the AQP family.	Hydrogen	25-33	aquaporin 1 (Colton blood group)	Homo sapiens	153-169
26893242-8	2016	Though the deprotonation of the O-HN hydrogen bond in (+) by another unit of {Os(II)(pap)2} generates a diastereomeric mixture of 5a(2+) and 5b(2+), attempts to deprotonate the relatively stronger O-H   O(-) hydrogen bond in 2(+) have failed.	Hydrogen	37-45	phospholipid phosphatase 1	Homo sapiens	85-90
26893242-8	2016	Though the deprotonation of the O-HN hydrogen bond in (+) by another unit of {Os(II)(pap)2} generates a diastereomeric mixture of 5a(2+) and 5b(2+), attempts to deprotonate the relatively stronger O-H   O(-) hydrogen bond in 2(+) have failed.	Hydrogen	208-216	phospholipid phosphatase 1	Homo sapiens	85-90
27026206-9	2016	Our data suggest that the beneficial effects of hydrogen-rich water on depressive-like behavior may be mediated by suppression of the inflammasome activation resulting in attenuated protein IL-1beta and ROS production.	Hydrogen	48-56	interleukin 1 beta	Mus musculus	190-198
26812210-10	2016	A p53-derived peptide binds with high affinity (Kd value of 150nM) and causes the formation of an extensive network of hydrogen bonds within MdmX; this constitutes the induction of order within MdmX through ligand binding.	Hydrogen	119-127	tumor protein p53	Homo sapiens	2-5
26797122-9	2016	The critical role for possible hydrogen bond interaction at apoA-I Tyr(166) was further supported using reconstituted HDL generated from apoA-I mutants (Tyr(166)   Glu or Asn), which showed preservation in both LCAT binding affinity and catalytic efficiency.	Hydrogen	31-39	apolipoprotein A1	Homo sapiens	60-66
26999566-3	2016	The aim of our study was to evaluate the association of elevated high-sensitivity cardiac troponin T levels (hs-cTnT) with the severity of disease expression and adverse events in patients with HCM.	Hydrogen	109-111	troponin T2, cardiac type	Homo sapiens	112-116
27231478-10	2016	Molecular Docking revealed hydrogen and hydrophobic interactions between alpha-amyrins with both active sites of COX-2 and 5-LOX enzymes.	Hydrogen	27-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	113-118
26774271-7	2016	Depletion of D-lactate levels in the dld3Delta, but not in the dld2Delta mutant, led to the discovery of a new type of enzymatic activity, carried by Dld3, to convert D-2HG to alpha-ketoglutarate, namely an FAD-dependent transhydrogenase activity using pyruvate as a hydrogen acceptor.	Hydrogen	226-234	D-lactate dehydrogenase	Saccharomyces cerevisiae S288C	150-154
26797122-9	2016	The critical role for possible hydrogen bond interaction at apoA-I Tyr(166) was further supported using reconstituted HDL generated from apoA-I mutants (Tyr(166)   Glu or Asn), which showed preservation in both LCAT binding affinity and catalytic efficiency.	Hydrogen	31-39	apolipoprotein A1	Homo sapiens	137-143
26741914-4	2016	In Hy1, orotic acid and water molecules are linked by strong hydrogen bonds in nearly perfectly planar arranged stacked layers.	Hydrogen	61-69	RNA, Ro60-associated Y1	Homo sapiens	3-6
28496522-2	2016	This PSMA macro-CTA was then utilised as a stabiliser block for the RAFT dispersion polymerisation of a highly polar monomer, N-2-(methacryloyloxy)ethyl pyrrolidone (NMEP), in n-dodecane at 90  C. 1H NMR studies confirmed that the rate of NMEP polymerisation was significantly faster than that of a non-polar monomer (benzyl methacrylate, BzMA) under the same conditions.	Hydrogen	197-199	folate hydrolase 1	Homo sapiens	5-9
28955863-6	2016	Moreover, Glu 285, Lys 286 forms aliphatic grove for TiO2-HSA, Ser-287 at the centre region form hydrogen bond with nanoparticle and Leu 283, Leu 284 forming hydrophopobic grove for TiO2 nanoparticle-HSA interaction.	Hydrogen	97-105	albumin	Homo sapiens	58-61
28955863-6	2016	Moreover, Glu 285, Lys 286 forms aliphatic grove for TiO2-HSA, Ser-287 at the centre region form hydrogen bond with nanoparticle and Leu 283, Leu 284 forming hydrophopobic grove for TiO2 nanoparticle-HSA interaction.	Hydrogen	97-105	albumin	Homo sapiens	200-203
26899350-1	2016	The electronic structure of black phosphorene (BP)/monolayer 1H-XT2 (X = Mo, W; T = S, Se, Te) two dimensional (2D) van der Waals heterostructures have been calculated by the first-principles method.	Hydrogen	61-63	xylosyltransferase 2	Homo sapiens	64-67
26859427-6	2016	Moreover, the CoX2 layer completely deposited on the Si surface functioned as a passivation layer by decreasing the oxide formation on Si MWs during solar hydrogen evolution.	Hydrogen	155-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-18
26844376-4	2016	The THz spectral comparison of the cocrystal with different directions and the cocrystal coformers indicates that the CL-20/TNT cocrystal has five fresh low-frequency absorption features as unique and discernible peaks for identification, in which 0.25, 0.73, and 0.87 THz are attributed to intensive crystalline vibrations; 0.87 THz is also caused by C-H   O hydrogen-bonding bending vibrations; 1.60 and 1.85 THz features originate from C-H   O hydrogen-bond stretching vibrations.	Hydrogen	360-368	epithelial membrane protein 1	Homo sapiens	118-123
26844376-4	2016	The THz spectral comparison of the cocrystal with different directions and the cocrystal coformers indicates that the CL-20/TNT cocrystal has five fresh low-frequency absorption features as unique and discernible peaks for identification, in which 0.25, 0.73, and 0.87 THz are attributed to intensive crystalline vibrations; 0.87 THz is also caused by C-H   O hydrogen-bonding bending vibrations; 1.60 and 1.85 THz features originate from C-H   O hydrogen-bond stretching vibrations.	Hydrogen	360-368	chromosome 16 open reading frame 82	Homo sapiens	124-127
26844376-4	2016	The THz spectral comparison of the cocrystal with different directions and the cocrystal coformers indicates that the CL-20/TNT cocrystal has five fresh low-frequency absorption features as unique and discernible peaks for identification, in which 0.25, 0.73, and 0.87 THz are attributed to intensive crystalline vibrations; 0.87 THz is also caused by C-H   O hydrogen-bonding bending vibrations; 1.60 and 1.85 THz features originate from C-H   O hydrogen-bond stretching vibrations.	Hydrogen	447-455	epithelial membrane protein 1	Homo sapiens	118-123
26844376-4	2016	The THz spectral comparison of the cocrystal with different directions and the cocrystal coformers indicates that the CL-20/TNT cocrystal has five fresh low-frequency absorption features as unique and discernible peaks for identification, in which 0.25, 0.73, and 0.87 THz are attributed to intensive crystalline vibrations; 0.87 THz is also caused by C-H   O hydrogen-bonding bending vibrations; 1.60 and 1.85 THz features originate from C-H   O hydrogen-bond stretching vibrations.	Hydrogen	447-455	chromosome 16 open reading frame 82	Homo sapiens	124-127
26938526-7	2016	In a molecular docking study, MOA was shown to target the binding site of ERK via the formation of three hydrogen bonds with two residues of the kinase, which is sufficient for the inhibition of ERK.	Hydrogen	105-113	mitogen-activated protein kinase 1	Mus musculus	74-77
26861239-9	2016	Persons with low SES and elevated hs-cTnT concentrations have the greatest risk of cardiovascular events, which suggests that this group should be aggressively targeted for cardiovascular risk reduction.	Hydrogen	34-36	troponin T2, cardiac type	Homo sapiens	37-41
26938526-7	2016	In a molecular docking study, MOA was shown to target the binding site of ERK via the formation of three hydrogen bonds with two residues of the kinase, which is sufficient for the inhibition of ERK.	Hydrogen	105-113	mitogen-activated protein kinase 1	Mus musculus	195-198
26411723-8	2016	RESULTS: Diaphragm tissue TNF-alpha level significantly increased in 1h and 24h groups (P=0.004, P=0.0001; respectively).	Hydrogen	69-71	tumor necrosis factor	Rattus norvegicus	26-35
26558997-1	2016	Kinetics of hydrogen formation was explored as a new chemical dosimeter allowing probing the sonochemical activity of argon-saturated water in the presence of micro- and nano-sized metal oxide particles exhibiting catalytic properties (ThO2, ZrO2, and TiO2).	Hydrogen	12-20	THO complex 2	Homo sapiens	236-240
26916313-12	2016	The most significant increase was in heparanase procoagulant activity at the time point of 1h post-surgery (P&lt;0.0001).	Hydrogen	91-93	heparanase	Homo sapiens	37-47
26875562-7	2016	Hydrogen treatment also blocked Ang II-induced phosphorylation of the extracellular signal-regulated kinase1/2 (ERK1/2), p38 MAPK, c-Jun NH2-terminal kinase (JNK) and the ezrin/radixin/moesin (ERM) in vitro.	Hydrogen	0-8	angiotensinogen	Homo sapiens	32-38
26875562-7	2016	Hydrogen treatment also blocked Ang II-induced phosphorylation of the extracellular signal-regulated kinase1/2 (ERK1/2), p38 MAPK, c-Jun NH2-terminal kinase (JNK) and the ezrin/radixin/moesin (ERM) in vitro.	Hydrogen	0-8	mitogen-activated protein kinase 1	Homo sapiens	70-110
26875562-7	2016	Hydrogen treatment also blocked Ang II-induced phosphorylation of the extracellular signal-regulated kinase1/2 (ERK1/2), p38 MAPK, c-Jun NH2-terminal kinase (JNK) and the ezrin/radixin/moesin (ERM) in vitro.	Hydrogen	0-8	mitogen-activated protein kinase 3	Homo sapiens	112-118
26875562-7	2016	Hydrogen treatment also blocked Ang II-induced phosphorylation of the extracellular signal-regulated kinase1/2 (ERK1/2), p38 MAPK, c-Jun NH2-terminal kinase (JNK) and the ezrin/radixin/moesin (ERM) in vitro.	Hydrogen	0-8	mitogen-activated protein kinase 1	Homo sapiens	121-124
26875562-7	2016	Hydrogen treatment also blocked Ang II-induced phosphorylation of the extracellular signal-regulated kinase1/2 (ERK1/2), p38 MAPK, c-Jun NH2-terminal kinase (JNK) and the ezrin/radixin/moesin (ERM) in vitro.	Hydrogen	0-8	mitogen-activated protein kinase 8	Homo sapiens	131-156
26875562-7	2016	Hydrogen treatment also blocked Ang II-induced phosphorylation of the extracellular signal-regulated kinase1/2 (ERK1/2), p38 MAPK, c-Jun NH2-terminal kinase (JNK) and the ezrin/radixin/moesin (ERM) in vitro.	Hydrogen	0-8	mitogen-activated protein kinase 8	Homo sapiens	158-161
26875562-8	2016	Taken together, our studies indicate that hydrogen prevents AAC-induced vascular hypertrophy in vivo, and inhibits Ang II-induced proliferation and migration of VSMCs in vitro possibly by targeting ROS-dependent ERK1/2, p38 MAPK, JNK and ERM signaling.	Hydrogen	42-50	angiotensinogen	Homo sapiens	115-121
26875562-8	2016	Taken together, our studies indicate that hydrogen prevents AAC-induced vascular hypertrophy in vivo, and inhibits Ang II-induced proliferation and migration of VSMCs in vitro possibly by targeting ROS-dependent ERK1/2, p38 MAPK, JNK and ERM signaling.	Hydrogen	42-50	mitogen-activated protein kinase 3	Homo sapiens	212-218
26875562-8	2016	Taken together, our studies indicate that hydrogen prevents AAC-induced vascular hypertrophy in vivo, and inhibits Ang II-induced proliferation and migration of VSMCs in vitro possibly by targeting ROS-dependent ERK1/2, p38 MAPK, JNK and ERM signaling.	Hydrogen	42-50	mitogen-activated protein kinase 1	Homo sapiens	220-223
26875562-8	2016	Taken together, our studies indicate that hydrogen prevents AAC-induced vascular hypertrophy in vivo, and inhibits Ang II-induced proliferation and migration of VSMCs in vitro possibly by targeting ROS-dependent ERK1/2, p38 MAPK, JNK and ERM signaling.	Hydrogen	42-50	mitogen-activated protein kinase 3	Homo sapiens	224-228
26875562-8	2016	Taken together, our studies indicate that hydrogen prevents AAC-induced vascular hypertrophy in vivo, and inhibits Ang II-induced proliferation and migration of VSMCs in vitro possibly by targeting ROS-dependent ERK1/2, p38 MAPK, JNK and ERM signaling.	Hydrogen	42-50	mitogen-activated protein kinase 8	Homo sapiens	230-233
26905012-9	2016	Restoring ERK phosphorylation by administration of molecular hydrogen ameliorated sevoflurane-induced apoptosis.	Hydrogen	61-69	mitogen-activated protein kinase 1	Mus musculus	10-13
26753183-6	2016	Further dissociation leads to electron transfer and hydrogen atom loss, generating a route to the radical anion of the Zn(II)Por/Pc without the need for electrochemical reduction, although the Zn(II)Por/Pc may have a too low electron affinity to allow electron transfer directly from the formate anion.	Hydrogen	52-60	cytochrome p450 oxidoreductase	Homo sapiens	125-128
26772148-8	2016	Rv2258c interacts with the bound SFG (or SAH) in an extended conformation maintained by a network of hydrogen bonds and stacking interactions.	Hydrogen	101-109	transcriptional regulator	Mycobacterium tuberculosis H37Rv	0-7
26700562-0	2016	A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.	Hydrogen	2-10	glucagon	Homo sapiens	51-74
26846460-9	2016	In KAT1, residue K85 within the linker forms a hydrogen bond with C211 that enables the pH activation; conversely, the linker of ZmK2.1 is distantly located and thus does not interact with the equivalent titration group (C208).	Hydrogen	47-55	1	Arabidopsis thaliana	3-7
26875562-2	2016	The purpose of this study is to evaluate the effects of hydrogen on proliferation and migration of vascular smooth muscle cells (VSMCs) stimulated by angiotensin II (Ang II) in vitro, and on vascular hypertrophy induced by abdominal aortic coarctation (AAC) in vivo.	Hydrogen	56-64	angiotensinogen	Homo sapiens	150-164
26875562-2	2016	The purpose of this study is to evaluate the effects of hydrogen on proliferation and migration of vascular smooth muscle cells (VSMCs) stimulated by angiotensin II (Ang II) in vitro, and on vascular hypertrophy induced by abdominal aortic coarctation (AAC) in vivo.	Hydrogen	56-64	angiotensinogen	Homo sapiens	166-172
26875562-5	2016	Hydrogen inhibited proliferation and migration of VSMCs with Ang II stimulation in vitro, and improved the vascular hypertrophy induced by AAC in vivo.	Hydrogen	0-8	angiotensinogen	Homo sapiens	61-67
26875562-6	2016	Treatment with hydrogen reduced Ang II- or AAC-induced oxidative stress, which was reflected by diminishing the induction of reactive oxygen species (ROS) in Ang II-stimulated VSMCs, inhibiting the levels of 3-nitrotyrosine (3-NT) in vascular and serum malondialdehyde (MDA).	Hydrogen	15-23	angiotensinogen	Homo sapiens	32-38
26641274-3	2016	We propose that the electron-withdrawing properties of -CHO and -COOH in 5fC and 5caC increase N3 acidity, leading to weakened hydrogen bonding and reduced base pair stability relative to C, 5mC, and 5hmC, thereby facilitating the selective recognition of 5fC and 5caC by TDG.	Hydrogen	127-135	thymine DNA glycosylase	Homo sapiens	272-275
25884403-0	2016	Meningeal blood flow is controlled by H2 S-NO crosstalk activating a HNO-TRPA1-CGRP signalling pathway.	Hydrogen	38-40	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	73-78
26844594-0	2016	Bottom-up Electrosynthesis of Highly Active Tungsten Sulfide (WS3-x) Films for Hydrogen Evolution.	Hydrogen	79-87	dynactin subunit 6	Homo sapiens	62-65
26804934-4	2016	The present study has utilized ATR-IR spectroscopy and thin silica particle films exposed to varying humidity to clearly show reversible conversion between surface siloxanes and hydrogen-bonded silanols without the need for semiempirical peak deconvolution.	Hydrogen	178-186	ATR serine/threonine kinase	Homo sapiens	31-34
26840724-8	2016	Force decomposition reveals how, for each tested molecule, interactions with water and the Cx26 protein vary over the length of the pore and reveals a significant contribution from hydrogen bonding and interaction with K(+).	Hydrogen	181-189	gap junction protein beta 2	Homo sapiens	91-95
25884403-14	2016	CONCLUSIONS AND IMPLICATIONS: NO and H2 S cooperatively increased meningeal blood flow by forming HNO, which activated TRPA1 cation channels in trigeminal fibres, inducing CGRP release.	Hydrogen	37-39	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	119-124
26705611-10	2016	Moreover, H2 treatment significantly decreased the number of 4-HNE-stained cells in the ganglion cell layer and inhibited the retinal overexpression of IL1-beta and TNF-alpha that was induced by retinal I/R injury.	Hydrogen	10-12	interleukin 1 beta	Rattus norvegicus	152-160
26705611-10	2016	Moreover, H2 treatment significantly decreased the number of 4-HNE-stained cells in the ganglion cell layer and inhibited the retinal overexpression of IL1-beta and TNF-alpha that was induced by retinal I/R injury.	Hydrogen	10-12	tumor necrosis factor	Rattus norvegicus	165-174
26526647-5	2016	Higher levels of reflection predicted lower IL-6 responses 1h after the stressor.	Hydrogen	59-61	interleukin 6	Homo sapiens	44-48
26913287-7	2016	These results indicate that steric, electrostatic, hydrophobic (lipophilic), and hydrogen bond donor substituents play significant roles in multidrug resistance modulation of tariquidar analogues upon MRP1.	Hydrogen	81-89	ATP binding cassette subfamily B member 1	Homo sapiens	201-205
26683671-6	2016	The subsequent in vitro experiments showed that H2 treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-kappaB and the expression of tumor necrosis factor alpha and interleukin-1beta, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus.	Hydrogen	48-50	mitogen-activated protein kinase 1	Homo sapiens	94-131
26683671-6	2016	The subsequent in vitro experiments showed that H2 treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-kappaB and the expression of tumor necrosis factor alpha and interleukin-1beta, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus.	Hydrogen	48-50	mitogen-activated protein kinase 1	Homo sapiens	133-136
26683671-6	2016	The subsequent in vitro experiments showed that H2 treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-kappaB and the expression of tumor necrosis factor alpha and interleukin-1beta, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus.	Hydrogen	48-50	mitogen-activated protein kinase 8	Homo sapiens	139-162
26683671-6	2016	The subsequent in vitro experiments showed that H2 treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-kappaB and the expression of tumor necrosis factor alpha and interleukin-1beta, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus.	Hydrogen	48-50	mitogen-activated protein kinase 8	Homo sapiens	164-167
26683671-6	2016	The subsequent in vitro experiments showed that H2 treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-kappaB and the expression of tumor necrosis factor alpha and interleukin-1beta, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus.	Hydrogen	48-50	tumor necrosis factor	Homo sapiens	230-257
26683671-6	2016	The subsequent in vitro experiments showed that H2 treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-kappaB and the expression of tumor necrosis factor alpha and interleukin-1beta, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus.	Hydrogen	48-50	interleukin 1 beta	Homo sapiens	262-279
26683671-6	2016	The subsequent in vitro experiments showed that H2 treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-kappaB and the expression of tumor necrosis factor alpha and interleukin-1beta, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus.	Hydrogen	48-50	mitogen-activated protein kinase 1	Homo sapiens	342-345
26683671-6	2016	The subsequent in vitro experiments showed that H2 treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-kappaB and the expression of tumor necrosis factor alpha and interleukin-1beta, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus.	Hydrogen	48-50	mitogen-activated protein kinase 8	Homo sapiens	355-358
26683671-9	2016	In conclusion, H2 treatment can ameliorate the inflammatory response and reduce the expression of inflammatory mediators during the early phase of AP by inhibiting the MAPK pathways and increasing Hsc70 expression.	Hydrogen	15-17	mitogen-activated protein kinase 1	Homo sapiens	168-172
26763193-3	2016	A simulated six-membered ring strategy formed through intramolecular hydrogen bonds was employed to mimic the planar quinazoline of the EGFR antagonist, gefitinib.	Hydrogen	69-77	epidermal growth factor receptor	Homo sapiens	136-140
26695099-6	2016	The overall association (&gt;11 kcal mol(-1) ), however, is strengthened by co-operative, synergistic classical hydrogen bonding when the NHC ligands bear NH units.	Hydrogen	112-120	high mobility group nucleosomal binding domain 4	Homo sapiens	138-141
26911623-4	2016	Here, we employ hydrogen-deuterium exchange coupled with mass spectrometry to reveal that Mis12 and Nnf1 form a dimer maintained by interacting coiled-coil (CC) domains within the carboxy-terminal parts of both proteins.	Hydrogen	16-24	Mis12	Drosophila melanogaster	90-95
26725500-6	2016	Notably, the Pt@Ni core-shell NPs with a patch-like Ni layer on Pt cores (0.5 and 1 h) show a higher H2 generation rate of 1221-1475 H2 mL min(-1) g(-1)cat than the Pt@Ni NPs with a thick Ni layer (2 and 4 h, 920-1183 H2 mL min(-1) g(-1)cat), and much higher than that of pure Pt NPs (224 H2 mL min(-1) g(-1)cat).	Hydrogen	101-103	CD59 molecule (CD59 blood group)	Homo sapiens	139-145
26725500-6	2016	Notably, the Pt@Ni core-shell NPs with a patch-like Ni layer on Pt cores (0.5 and 1 h) show a higher H2 generation rate of 1221-1475 H2 mL min(-1) g(-1)cat than the Pt@Ni NPs with a thick Ni layer (2 and 4 h, 920-1183 H2 mL min(-1) g(-1)cat), and much higher than that of pure Pt NPs (224 H2 mL min(-1) g(-1)cat).	Hydrogen	101-103	CD59 molecule (CD59 blood group)	Homo sapiens	224-230
26725500-6	2016	Notably, the Pt@Ni core-shell NPs with a patch-like Ni layer on Pt cores (0.5 and 1 h) show a higher H2 generation rate of 1221-1475 H2 mL min(-1) g(-1)cat than the Pt@Ni NPs with a thick Ni layer (2 and 4 h, 920-1183 H2 mL min(-1) g(-1)cat), and much higher than that of pure Pt NPs (224 H2 mL min(-1) g(-1)cat).	Hydrogen	101-103	CD59 molecule (CD59 blood group)	Homo sapiens	224-230
26529665-0	2016	HYDROGEN-RICH MEDIUM AMELIORATES LIPOPOLYSACCHARIDE-INDUCED BARRIER DYSFUNCTION VIA RHOA-MDIA1 SIGNALING IN CACO-2 CELLS.	Hydrogen	0-8	ras homolog family member A	Homo sapiens	84-88
26529665-11	2016	Moreover, H2 improved the down-regulated expression and redistribution of occludin and E-cadherin caused by LPS.	Hydrogen	10-12	cadherin 1	Homo sapiens	87-97
26529665-12	2016	Additionally, H2 alleviated LPS-caused RhoA activation, and the beneficial effects of H2 on barrier were counteracted by RhoA agonist CN03.	Hydrogen	14-16	ras homolog family member A	Homo sapiens	39-43
26529665-12	2016	Additionally, H2 alleviated LPS-caused RhoA activation, and the beneficial effects of H2 on barrier were counteracted by RhoA agonist CN03.	Hydrogen	86-88	ras homolog family member A	Homo sapiens	121-125
26529665-16	2016	These findings suggest that H2 improves LPS-induced hyperpermeability of the intestinal barrier and disruptions of TJ and AJ by moderating RhoA-mDia1 signaling.	Hydrogen	28-30	ras homolog family member A	Homo sapiens	139-143
26840286-1	2016	A novel series of pyrene containing thiophene monomers TPM1-5 were synthesized and fully characterized by FTIR, MS, 1H- and (13)C-NMR spectroscopy; their thermal properties were determined by TGA and DSC.	Hydrogen	116-118	tropomyosin 1	Homo sapiens	55-61
26565028-1	2016	The mechanism of omega-6 polyunsaturated fatty acid oxidation by wild-type cyclooxygenase 2 and the Y334F variant, lacking a conserved hydrogen bond to the catalytic tyrosyl radical/tyrosine, was examined for the first time under physiologically relevant conditions.	Hydrogen	135-143	prostaglandin-endoperoxide synthase 2	Homo sapiens	75-91
26730968-7	2016	We demonstrate the capability of the design by acquiring a 1H spectrum of ~ 11 nmol sucrose dissolved in D2O, where we achieved a linewidth of 1.25 Hz for the TSP reference peak.	Hydrogen	59-61	thrombospondin 1	Homo sapiens	159-162
26985305-2	2016	When cocrystallized with CDK8 and cyclin C, these compounds exhibit an unusual binding mode, making a single hydrogen bond to the hinge residue A100, a second to K252, and a key cation-pi interaction with R356.	Hydrogen	109-117	cyclin dependent kinase 8	Homo sapiens	25-29
26361765-9	2016	Molecular docking studies indicated different hydrogen bonds and pi-pi interactions between CYP3A4 and CYP3A5, which might result in the different catalytic activity for GA 8-hydroxylation.	Hydrogen	46-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	92-98
26725083-3	2016	The current work conceptualizes a model for the GPIHBP1 LPL interaction based on biophysical measurements with hydrogen-deuterium exchange/mass spectrometry, surface plasmon resonance, and zero-length cross-linking.	Hydrogen	111-119	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	Homo sapiens	48-55
26600404-8	2016	Strong hydrogen bonds between (alpha1 + alpha2) and alpha3 differ between SC1 and SC2 but are nearly invariant within each SC.	Hydrogen	7-15	trans-2,3-enoyl-CoA reductase	Homo sapiens	82-85
26361765-9	2016	Molecular docking studies indicated different hydrogen bonds and pi-pi interactions between CYP3A4 and CYP3A5, which might result in the different catalytic activity for GA 8-hydroxylation.	Hydrogen	46-54	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	103-109
26151827-6	2016	The development of ANG II-induced hypertension was exacerbated by 4%HS in both control (125 +- 3 to 164 +- 5 mmHg) and UB(Bdkrb2-/-) mice (124 +- 2 to 162 +- 3 mmHg) during 2 weeks.	Hydrogen	68-70	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	19-25
26596858-9	2016	Our findings showed that up-regulation of Drp1 expression started at 1h post-TBI and peaked at 24 h, but inhibition of Drp1 by Mdivi-1 significantly alleviated TBI-induced behavioral deficits and brain edema, reduced morphological change of mitochondria, and decreased TBI-induced cell death together with lesion volume.	Hydrogen	69-71	dynamin 1-like	Mus musculus	42-46
27640395-1	2016	A hydrated hydrazone compound, 4-fluoro-N"-(2-hydroxy-3-methoxybenzylidene)benzohydrazide monohydrate (H2L   H2O), was prepared and characterized by elemental analysis, HRMS, IR, UV-Vis and 1H NMR spectroscopy.	Hydrogen	190-192	histocompatibility 2, D region locus L	Mus musculus	103-106
26151827-7	2016	Interestingly, 8%HS caused a more profound and earlier ANG II-induced hypertension in UB(Bdkrb2-/-) (129 +- 2 to 166 +- 3 mmHg) as compared to control (128 +- 2 to 158 +- 2 mmHg) and it was accompanied by body weight loss and increased mortality.	Hydrogen	17-19	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	55-61
27697060-7	2016	Both, hydrogen bond and hydrophobic interactions were found to be involved in the proper positioning of these diabetic drugs within the catalytic site (CAS) of AChE and BACE enzymes to permit docking.	Hydrogen	6-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	160-164
27585602-9	2016	Molecular docking revealed that hydrogen bond interactions with Lys38, Glu85 and Cys87 are essential for Chk1 inhibitory activity.	Hydrogen	32-40	checkpoint kinase 1	Homo sapiens	105-109
26268339-7	2016	In particular, FLAP, a program based on GRID molecular interaction fields, was used to analyze the ligand-protein interactions: molecular shape and hydrogen bond acceptor groups strongly influence the binding according to the ligand-based modeling, while the aromatic interactions are better identified by the structure-based study.	Hydrogen	148-156	arachidonate 5-lipoxygenase activating protein	Homo sapiens	15-19
27697060-7	2016	Both, hydrogen bond and hydrophobic interactions were found to be involved in the proper positioning of these diabetic drugs within the catalytic site (CAS) of AChE and BACE enzymes to permit docking.	Hydrogen	6-14	beta-secretase 1	Homo sapiens	169-173
27019194-2	2016	The preparation was performed in the presence of insulin due to the formation of hydrogen bonds between poly(vinyl pyrrolidone) (PVP) and poly(acrylic acid) (PAA) or its conjugate poly(acrylic acid)-cysteine (PAA-Cys) with a molecular mass of 100 as well as 450 kDa.	Hydrogen	81-89	insulin	Homo sapiens	49-56
25933061-6	2016	Moreover, the formed important hydrogen bonds of Tyr1203 residue with XVA939 and WAT1551 with ISX enhance stabilities of the complexes, and the electrostatic interactions in XAV939-TNKS1 and van der Waals interactions in ISX-TNKS1 system are main driving forces for affinity.	Hydrogen	31-39	tankyrase	Homo sapiens	181-186
27034690-8	2016	In addition, the results of molecular docking showed that xanthotoxol was bound to CYP1A2 with hydrophobic and pi-pi bond and CYP3A4 with hydrogen and hydrophobic bond.	Hydrogen	138-146	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	126-132
27215098-1	2016	BACKGROUND: Little is known about the effects of preanalytical conditions on high-sensitivity cardiac troponin T (hs-cTnT) concentrations.	Hydrogen	114-116	troponin T2, cardiac type	Homo sapiens	117-121
26460595-6	2016	This variability stems in part from the fact that the effector/GCPII interfaces generally encompass isolated areas of nonpolar residues within the entrance funnel and resulting van der Waals contacts lack the directionality typical for hydrogen bonding interactions.	Hydrogen	236-244	folate hydrolase 1	Homo sapiens	63-68
25933061-6	2016	Moreover, the formed important hydrogen bonds of Tyr1203 residue with XVA939 and WAT1551 with ISX enhance stabilities of the complexes, and the electrostatic interactions in XAV939-TNKS1 and van der Waals interactions in ISX-TNKS1 system are main driving forces for affinity.	Hydrogen	31-39	tankyrase	Homo sapiens	225-230
26096169-5	2016	It was found that the insertion and duplication mutations in exon 20 can generally cause drug resistance to EGFR due to the reduced size of kinase"s active pocket, while deletion mutations in exon 19 associate closely with increased inhibitor sensitivity to EGFR by establishing additional non-bonded interactions across complex interface, including hydrogen bonds, cation-pi interactions and hydrophobic contacts.	Hydrogen	350-358	epidermal growth factor receptor	Homo sapiens	108-112
26096169-5	2016	It was found that the insertion and duplication mutations in exon 20 can generally cause drug resistance to EGFR due to the reduced size of kinase"s active pocket, while deletion mutations in exon 19 associate closely with increased inhibitor sensitivity to EGFR by establishing additional non-bonded interactions across complex interface, including hydrogen bonds, cation-pi interactions and hydrophobic contacts.	Hydrogen	350-358	epidermal growth factor receptor	Homo sapiens	258-262
26585176-9	2016	In silico studies demonstrate that DHMA formed hydrogen bond interaction with key residues Trp26, Phe55 and Lys24 by which it disrupt the binding of p53 with MDM2 receptor.	Hydrogen	47-55	tumor protein p53	Homo sapiens	149-152
26485295-9	2016	The results of thermodynamic action between Gd-DTPA-DMABA-CS11 and bovine serum albumin (BSA) illustrated that the binding process was exothermic and spontaneous, and the main force was van der Waals" interaction and hydrogen bond.	Hydrogen	217-225	albumin	Homo sapiens	74-87
26798423-3	2016	The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic oxidative stress and proinflammatory cytokine levels and promoting healing-associated genes.	Hydrogen	47-55	NFE2 like bZIP transcription factor 2	Rattus norvegicus	104-108
26833077-9	2016	The compound forms strong hydrogen bonding at the peripheral anionic site of AChE whereas on BChE, it had hydrophobic and mild polar interactions.	Hydrogen	26-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-81
27429605-5	2016	METHODS: Using non-destructive HR-MAS 1H NMR spectroscopy we analysed the metabolic changes induced by decreased AR signalling in human prostate cancer tissue samples.	Hydrogen	38-40	androgen receptor	Homo sapiens	113-115
27491651-8	2016	Structural analysis revealed an intensive network of hydrogen bonds and hydrophobic interactions in HER2(YVMA)  bosutinib complex, whereas only few nonspecific van der Waals contacts were observed at the complex interface of HER2(YVMA) with gefitinib.	Hydrogen	53-61	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-104
27499603-7	2016	Main contributions to the higher affinity of Acteoside to C5aR are the exceptionally strong lipophilic interaction, enhanced electrostatics and hydrogen bond interactions.	Hydrogen	144-152	complement C5a receptor 1	Homo sapiens	58-62
26518243-5	2016	Pre-treatment for 1h with 10nM PT-3 augmented BMP-9 transdifferentiation effect, elevated betaIII-tubulin cell numbers and fluorescence intensity of immunoreactive ChAT, ameliorated BMP-9-related production of reactive oxygen species and enhanced anti-apoptosis status of the neuronal-like cells.	Hydrogen	18-20	zinc finger protein 135	Homo sapiens	31-35
26518243-5	2016	Pre-treatment for 1h with 10nM PT-3 augmented BMP-9 transdifferentiation effect, elevated betaIII-tubulin cell numbers and fluorescence intensity of immunoreactive ChAT, ameliorated BMP-9-related production of reactive oxygen species and enhanced anti-apoptosis status of the neuronal-like cells.	Hydrogen	18-20	growth differentiation factor 2	Homo sapiens	46-51
26518243-5	2016	Pre-treatment for 1h with 10nM PT-3 augmented BMP-9 transdifferentiation effect, elevated betaIII-tubulin cell numbers and fluorescence intensity of immunoreactive ChAT, ameliorated BMP-9-related production of reactive oxygen species and enhanced anti-apoptosis status of the neuronal-like cells.	Hydrogen	18-20	growth differentiation factor 2	Homo sapiens	182-187
26798423-0	2016	Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model.	Hydrogen	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	88-92
26798423-7	2016	As molecular hydrogen upregulated the Nrf2 pathway, systemic oxidative stresses were decreased by the activation of antioxidant activity.	Hydrogen	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	38-42
26798423-9	2016	In conclusion, hydrogen-rich water intake exhibited multiple beneficial effects through activation of the Nrf2/antioxidant defense pathway.	Hydrogen	15-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	106-110
27822364-6	2016	Molecular docking analysis revealed that compound 1 could bind stably to the TRAIL/DR5 complex through hydrogen bonds.	Hydrogen	103-111	TNF superfamily member 10	Homo sapiens	77-82
26529477-6	2016	Type I, I1/2, and type II inhibitors occupy part of the adenine binding pocket and form hydrogen bonds with the hinge region connecting the small and large lobes of the enzyme.	Hydrogen	88-96	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	8-25
25527460-1	2016	The quantum yield for light-induced H2 generation was measured for a previously optimized bio-hybrid cytochrome c 6-crosslinked PSI(C13G)-1,8-octanedithiol-[FeFe]-H2ase(C97G) (PSI-H2ase) nanoconstruct.	Hydrogen	36-38	cytochrome c, somatic	Homo sapiens	101-113
26902251-0	2016	Mechanism of Lipid Binding of Human Apolipoprotein E3 by Hydrogen/Deuterium Exchange/Mass Spectrometry and Fluorescence Polarization.	Hydrogen	57-65	apolipoprotein E	Homo sapiens	36-53
26172469-2	2015	Two intramolecular hydrogen bonds (HB1 and HB2) are formed between hydroxyl and carbonyl groups of AS1.	Hydrogen	19-27	histocompatibility minor HB-1	Homo sapiens	35-38
27445442-1	2016	The collision of two cylindrical hydrogen-free diamond-like carbon (DLC) asperities with approximately 60 % sp3 hybridization has been studied using classical molecular dynamics.	Hydrogen	33-41	Sp3 transcription factor	Homo sapiens	108-111
26596710-0	2015	Discovery of novel quinoline-based mTOR inhibitors via introducing intra-molecular hydrogen bonding scaffold (iMHBS): The design, synthesis and biological evaluation.	Hydrogen	83-91	mechanistic target of rapamycin kinase	Homo sapiens	35-39
26587763-2	2015	Under H2O and H2 atmospheres, hydrogens derived from H2O or H2 molecules were introduced into the oxygen sites as a hydride ion, and SmFeAsO(1-x)Hx was obtained.	Hydrogen	30-39	fibroblast growth factor receptor 1	Homo sapiens	6-16
26634958-4	2015	During the MD simulation, ArgP1 in a substrate accessed thrombin"s substrate-binding pocket and formed specific hydrogen bonds (H-bonds) with Asp189 in thrombin, while the catalytic serine of thrombin was still away from the substrate"s active site.	Hydrogen	112-120	coagulation factor II, thrombin	Homo sapiens	56-64
26634958-4	2015	During the MD simulation, ArgP1 in a substrate accessed thrombin"s substrate-binding pocket and formed specific hydrogen bonds (H-bonds) with Asp189 in thrombin, while the catalytic serine of thrombin was still away from the substrate"s active site.	Hydrogen	112-120	coagulation factor II, thrombin	Homo sapiens	152-160
26634958-4	2015	During the MD simulation, ArgP1 in a substrate accessed thrombin"s substrate-binding pocket and formed specific hydrogen bonds (H-bonds) with Asp189 in thrombin, while the catalytic serine of thrombin was still away from the substrate"s active site.	Hydrogen	112-120	coagulation factor II, thrombin	Homo sapiens	152-160
26568481-6	2015	We found that the possibility of forming H-bonds among solvent molecules and between the carbene carbon and the hydrogen of the solvent molecule affects the stability, structure and nature of CcO interactions in O-ylides and O-ylidic complexes to the point of generating some diffuse borderlines between these two kinds of species.	Hydrogen	112-120	ryanodine receptor 1	Homo sapiens	192-195
26570983-1	2015	The side chains of Y208 and S211 from loop 7 of triosephosphate isomerase (TIM) form hydrogen bonds to backbone amides and carbonyls from loop 6 to stabilize the caged enzyme-substrate complex.	Hydrogen	85-93	triosephosphate isomerase 1	Homo sapiens	48-73
26570983-1	2015	The side chains of Y208 and S211 from loop 7 of triosephosphate isomerase (TIM) form hydrogen bonds to backbone amides and carbonyls from loop 6 to stabilize the caged enzyme-substrate complex.	Hydrogen	85-93	triosephosphate isomerase 1	Homo sapiens	75-78
26473402-2	2015	This reactivity also yields a stoichiometric quantity of Me2 PhSiH and provides the first example of a catalytic main-group element-element coupling that is not dependent on the concurrent elimination of H2 .	Hydrogen	204-206	malic enzyme 2	Homo sapiens	57-60
26626480-4	2015	By monitoring PARP-1 dynamics using hydrogen/deuterium exchange-mass spectrometry (HXMS), we unexpectedly find that a specific portion of the helical subdomain (HD) of the catalytic domain rapidly unfolds when PARP-1 encounters a DNA break.	Hydrogen	36-44	poly(ADP-ribose) polymerase 1	Homo sapiens	14-20
26668628-12	2015	Furthermore, hydrogen-rich saline regulated the Nrf2 protein expression in rats with ovarian damage.	Hydrogen	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	48-52
26506994-7	2015	A metaanalysis of the 3 cohorts showed participants with hs-cTnT between the LOB and LOD were at increased risk of new-onset heart failure (hazard ratio, 1.18; 95% CI, 1.02-1.38) and cardiovascular mortality (hazard ratio, 1.29; 95% CI, 1.06-1.57).	Hydrogen	57-59	troponin T2, cardiac type	Homo sapiens	60-64
26668628-13	2015	In conclusion, hydrogen-rich saline exerts a protective effect against cisplatin-induced ovarian injury by reducing MDA and increasing SOD and CAT activity.	Hydrogen	15-23	catalase	Rattus norvegicus	143-146
26041159-4	2015	These results are explained in terms of the binding of quercetin to the hydrophobic pockets of SPI particles mainly through the hydrophobic force together with the hydrogen bonding.	Hydrogen	164-172	chromogranin A	Homo sapiens	95-98
26384859-6	2015	Modeling study indicated that TFCA inhibited activation of the LXRalpha ligand-binding domain by hydrogen bonding to Arg305 in the H5 region of that domain.	Hydrogen	97-105	nuclear receptor subfamily 1, group H, member 3	Mus musculus	63-71
26742324-10	2015	HS group showed significantly higher (P &lt; 0.05) superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) activity, and ferric reducing antioxidant power (FRAP) compared to only HFD fed group.	Hydrogen	0-2	catalase	Mus musculus	79-87
26742324-10	2015	HS group showed significantly higher (P &lt; 0.05) superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) activity, and ferric reducing antioxidant power (FRAP) compared to only HFD fed group.	Hydrogen	0-2	catalase	Mus musculus	89-92
26720481-0	2015	Sirtuin Type 1 Mediates the Retinal Protective Effect of Hydrogen-Rich Saline Against Light-Induced Damage in Rats.	Hydrogen	57-65	sirtuin 1	Rattus norvegicus	0-14
26720481-11	2015	Hydrogen-rich saline also increased B-cell lymphoma 2 (Bcl-2) expression and the activity of the antioxidant enzyme superoxide dismutase (SOD).	Hydrogen	0-8	BCL2, apoptosis regulator	Rattus norvegicus	36-53
26720481-11	2015	Hydrogen-rich saline also increased B-cell lymphoma 2 (Bcl-2) expression and the activity of the antioxidant enzyme superoxide dismutase (SOD).	Hydrogen	0-8	BCL2, apoptosis regulator	Rattus norvegicus	55-60
26507163-6	2015	mRNA and protein expressions of IL-1beta and IL-8 decreased significantly when pretreated HCECs with recombinant human SP-D for 4h before A. fumigatus stimulation, while IL-1beta and IL-8 increased when pretreated with SP-D antibody for 1h.	Hydrogen	237-239	interleukin 1 beta	Homo sapiens	32-40
26507163-6	2015	mRNA and protein expressions of IL-1beta and IL-8 decreased significantly when pretreated HCECs with recombinant human SP-D for 4h before A. fumigatus stimulation, while IL-1beta and IL-8 increased when pretreated with SP-D antibody for 1h.	Hydrogen	237-239	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
26372305-6	2015	The results indicated that treatment with TGF-beta1, 2, 3 and HCl decreased cell attachment, however, this effect was significantly greater in the case of TGF-beta3 (p&lt;0.001) indicating perhaps that TGF-beta3 does not act alone in cell detachment, but instead functions synergistically with signalling pathways that are dependent on the availability of hydrogen ions.	Hydrogen	356-364	transforming growth factor beta 1	Homo sapiens	42-51
26526852-4	2015	Comparison of this extensive solvent-mediated hydrogen-bonding network with the positions of ordered solvent in earlier crystallographic structures of rhodopsin photointermediates reveals both static structural and dynamic functional water-protein interactions present during the activation process.	Hydrogen	46-54	rhodopsin	Homo sapiens	151-160
26486475-6	2015	Complementary molecular dynamics simulations of the SCN(-)/D2O system indicate that the breaking and making of hydrogen-bonds between the terminal N-atom of the anion and the D2O molecules are induced by the same solvent-shell librational degrees of freedom that drive the vibrational line broadening dynamics seen in the 2DIR experiment.	Hydrogen	111-119	arginine vasopressin receptor 2	Homo sapiens	323-326
26550848-1	2015	A unique cooperative H2 activation reaction by heterobimetallic (NHC)M"-MCp(CO)2 complexes (NHC = N-heterocyclic carbene, M" = Cu or Ag, M = Fe or Ru) has been leveraged to develop a catalytic alkyne semi-hydrogenation transformation.	Hydrogen	21-23	CD46 molecule	Homo sapiens	72-75
26629323-11	2015	A docking simulation between JAK3 inhibitor VI and the ATP-binding pocket of EGFR T790M/L858R predicted a potential binding status with hydrogen bonds.	Hydrogen	136-144	epidermal growth factor receptor	Homo sapiens	77-81
26602442-5	2015	The first folding step initiates at 320 K upon the hydrophobic collapse of the Trp5 and Trp13 side-chains which stabilizes the concurrent beta-turn formation, whose COi-HNi + 3 hydrogen bond (Asp10   Arg7) appears particularly stable.	Hydrogen	177-185	transient receptor potential cation channel subfamily C member 5	Homo sapiens	79-83
26514688-2	2015	In this work, the host-guest interaction between fac-[Re(CO)3Cl(L)] with L = 4-([2,2"-bipyridin]-4-yl)phenol and fluoride ions is investigated for the hydrogen bond dynamics and the changing local coordination environment.	Hydrogen	151-159	FA complementation group C	Homo sapiens	49-52
26579714-12	2015	This parameter has been observed to be able to mimic the binding affinity of the p53 ts-mutants at 300 K and 310 K. Thus the correlation between MM-GBSA free energy of binding and hydrogen bonds formed by the interface residues between p53 and DNA has revealed the temperature dependent nature of these mutants.	Hydrogen	180-188	tumor protein p53	Homo sapiens	236-239
26403489-2	2015	The key to success of the reaction is the use of a Knolker-type complex as catalyst (2 mol %) in the presence of Cs2 CO3 as base (10 mol %) under hydrogen-borrowing conditions.	Hydrogen	146-154	chorionic somatomammotropin hormone 2	Homo sapiens	113-116
26597878-17	2015	In in silico studies, it was observed that IC showed hydrogen bonding with GLN 47 amino acid residue of TNF-alpha protein.	Hydrogen	53-61	tumor necrosis factor	Mus musculus	104-113
26467920-1	2015	We investigated the defected two-dimensional materials MoX2 (X = O, S, Se) for hydrogen evolution reaction by first principles calculations.	Hydrogen	79-87	mesenchyme homeobox 2	Homo sapiens	55-59
26467920-2	2015	While the basal plane is inert for pristine MoX2, we found that the defected MoX2 can adsorb hydrogen atoms at defect sites, with appropriate adsorption energies for hydrogen evolution.	Hydrogen	93-101	mesenchyme homeobox 2	Homo sapiens	77-81
26467920-2	2015	While the basal plane is inert for pristine MoX2, we found that the defected MoX2 can adsorb hydrogen atoms at defect sites, with appropriate adsorption energies for hydrogen evolution.	Hydrogen	166-174	mesenchyme homeobox 2	Homo sapiens	77-81
26467920-6	2015	We found that C and O adatoms can make defected MoX2 ideal for hydrogen evolution at higher defect levels (H coverage).	Hydrogen	63-71	mesenchyme homeobox 2	Homo sapiens	48-52
26579714-12	2015	This parameter has been observed to be able to mimic the binding affinity of the p53 ts-mutants at 300 K and 310 K. Thus the correlation between MM-GBSA free energy of binding and hydrogen bonds formed by the interface residues between p53 and DNA has revealed the temperature dependent nature of these mutants.	Hydrogen	180-188	tumor protein p53	Homo sapiens	81-84
26579717-10	2015	1H/15N HSQC NMR analysis of the rGad m 1:scFv-gco9 complex showed participation of amino acid residues conserved among these three parvalbumins explaining their cross-reactivity on a molecular level.	Hydrogen	0-2	immunglobulin heavy chain variable region	Homo sapiens	41-45
26475929-9	2015	Mutations of residues making hydrogen bonds to the pyrophosphate moiety also abrogated TNF-alpha secretion, as did mutation of aromatic residues making contact with the alkenyl chain.	Hydrogen	29-37	tumor necrosis factor	Homo sapiens	87-96
26468911-2	2015	We present oxime (HI-6) unbinding from the active site gorge of AChE, known to be strongly influenced by intermolecular cation-pi, hydrogen bridge (HB) and water bridge (WB) interactions and by molecular simulations with effective polarization in polarizable mean-field model of TIP3P water.	Hydrogen	131-139	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
26644780-7	2015	For other beta-amino acids, a hydrogen-accepting matrix was used to induce formation of site-specific a-14 ions from a synthetic beta-analogue of substance P.	Hydrogen	30-38	tachykinin precursor 1	Homo sapiens	146-157
26426584-0	2015	Earth-abundant NiS co-catalyst modified metal-free mpg-C3N4/CNT nanocomposites for highly efficient visible-light photocatalytic H2 evolution.	Hydrogen	129-131	solute carrier family 5 member 5	Homo sapiens	15-18
26426584-4	2015	The results showed that the loading of earth-abundant NiS co-catalysts onto metal-free mpg-C3N4/CNT nanocomposites can remarkably enhance their photocatalytic H2-production activity.	Hydrogen	159-161	solute carrier family 5 member 5	Homo sapiens	54-57
26426584-6	2015	The as-obtained mpg-C3N4/CNT/1% NiS ternary composite photocatalyst exhibits the best H2-evolution activity with the highest rate of about 521 mumol g(-1) h(-1) under visible light (lambda&gt;= 420 nm), which is almost 148 times that of a pure mpg-C3N4/CNT sample.	Hydrogen	86-88	solute carrier family 5 member 5	Homo sapiens	32-35
26538033-0	2015	Ring-Polymer Molecular Dynamics for the Prediction of Low-Temperature Rates: An Investigation of the C((1)D) + H2 Reaction.	Hydrogen	111-113	C1D nuclear receptor corepressor	Homo sapiens	101-107
26538033-5	2015	Here, we test this technique at low temperatures (300-50 K) by analyzing the behavior of the barrierless C((1)D) + H2 reaction over the two lowest singlet potential energy surfaces.	Hydrogen	115-117	C1D nuclear receptor corepressor	Homo sapiens	105-111
26344206-7	2015	Structural and energetic analyses of the modeled structures of the PARP-1 catalytic domain complexed with the newly identified inhibitors revealed a common binding mode in the complexes: the active site of PARP-1 is composed of a thin polar helix and a flat non-polar pocket; the inhibitors can form a number of hydrogen bonds and electrostatic forces with the helix, while tightly packing against the pocket to define chemical interactions.	Hydrogen	312-320	poly(ADP-ribose) polymerase 1	Homo sapiens	67-73
26276082-0	2015	Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression.	Hydrogen	10-18	NFE2 like bZIP transcription factor 2	Homo sapiens	104-108
26276082-6	2015	However, the protective function of H2 was abolished when Nrf2 was silenced.	Hydrogen	36-38	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
26276082-8	2015	In conclusion, our study shows that H2 protects intrahepatic cholangiocytes from hypoxia/reoxygenation-induced apoptosis in vitro or in vivo, and this phenomenon may depend on activating Nrf2 expression.	Hydrogen	36-38	NFE2 like bZIP transcription factor 2	Homo sapiens	187-191
26344206-7	2015	Structural and energetic analyses of the modeled structures of the PARP-1 catalytic domain complexed with the newly identified inhibitors revealed a common binding mode in the complexes: the active site of PARP-1 is composed of a thin polar helix and a flat non-polar pocket; the inhibitors can form a number of hydrogen bonds and electrostatic forces with the helix, while tightly packing against the pocket to define chemical interactions.	Hydrogen	312-320	poly(ADP-ribose) polymerase 1	Homo sapiens	206-212
30090267-5	2015	For carbon atoms without an attached hydrogen, a dipolar enhancement usually dominates as we illustrate for sp2 hybridized carbons in the fullerenes, C60 and C70.	Hydrogen	37-45	Sp2 transcription factor	Homo sapiens	108-111
26566302-8	2015	However, these levels were significantly reduced when H2 was administered prior to the LPS-injection.	Hydrogen	54-56	toll-like receptor 4	Mus musculus	87-90
26397063-6	2015	The results showed that PPARgamma, as a target of miR-27b, played a significant role in suppressing cervical cancer progression by downregulating the sodium-hydrogen exchanger isoform 1 (NHE1).	Hydrogen	157-165	peroxisome proliferator activated receptor gamma	Homo sapiens	24-33
26397063-6	2015	The results showed that PPARgamma, as a target of miR-27b, played a significant role in suppressing cervical cancer progression by downregulating the sodium-hydrogen exchanger isoform 1 (NHE1).	Hydrogen	157-165	solute carrier family 9 member A1	Homo sapiens	187-191
25862735-6	2015	Modeling results showed that p.A59P adds 2 hydrogen bonds and changes the structural conformation of MeCP2 with a significant root mean square deviation value (9.66 A), suggesting that this mutation could probably affect the conformation, function and stability of MeCP2.	Hydrogen	43-51	methyl-CpG binding protein 2	Homo sapiens	101-106
25862735-6	2015	Modeling results showed that p.A59P adds 2 hydrogen bonds and changes the structural conformation of MeCP2 with a significant root mean square deviation value (9.66 A), suggesting that this mutation could probably affect the conformation, function and stability of MeCP2.	Hydrogen	43-51	methyl-CpG binding protein 2	Homo sapiens	265-270
26566302-9	2015	Our results suggest that LPS-induced apoptosis, oxidative damage and inflammation in the fetal brain were ameliorated by maternal H2 administration.	Hydrogen	130-132	toll-like receptor 4	Mus musculus	25-28
26399304-5	2015	We attributed this difference to the formation of the PdH-O hydrogen bond with Pd(PPh3)2 which was surprisingly observed in explicit modeling.	Hydrogen	60-68	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	54-57
26499496-5	2015	Results explained that one hydrogen bond acceptor, two aromatic rings and two hydrophobic groups are crucial for the PDE4 inhibition.	Hydrogen	27-35	phosphodiesterase 4A	Homo sapiens	117-121
26499496-6	2015	The docking studies of all selected inhibitors in the active site of PDE4 showed crucial hydrogen bond interactions with Asp392, Asn395 Tyr233, and Gln443 residues.	Hydrogen	89-97	phosphodiesterase 4A	Homo sapiens	69-73
26239085-13	2015	This compound detected Mec-1 tumors by micro-PET/CT as early as 1h post-injection and at time points out to 48 h. However, the negative control Ramos tumor could not be detected.	Hydrogen	64-66	ATR serine/threonine kinase	Homo sapiens	23-28
26603451-0	2015	Chloride-hydrogen antiporters ClC-3 and ClC-5 drive osteoblast mineralization and regulate fine-structure bone patterning in vitro.	Hydrogen	9-17	chloride channel, voltage-sensitive 3	Mus musculus	30-35
26603451-0	2015	Chloride-hydrogen antiporters ClC-3 and ClC-5 drive osteoblast mineralization and regulate fine-structure bone patterning in vitro.	Hydrogen	9-17	chloride channel, voltage-sensitive 5	Mus musculus	40-45
26461140-5	2015	Weak hydrogen bonding from an electrostatic interaction between the CHF2 hydrogen and the central CF2 fluorines was not found to rule the conformational isomerism of enflurane.	Hydrogen	5-13	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	68-72
26207449-3	2015	This study found, using amide hydrogen/deuterium (H/D) exchange, capillary electrophoresis, and lysine-acetyl protein charge ladders, that ALS-linked A4V SOD1 rapidly monomerizes and partially unfolds in an external electric field (of physiological strength), without loss of metal ions, exposure to disulfide-reducing agents, or Joule heating.	Hydrogen	30-38	superoxide dismutase 1	Homo sapiens	139-142
26207449-3	2015	This study found, using amide hydrogen/deuterium (H/D) exchange, capillary electrophoresis, and lysine-acetyl protein charge ladders, that ALS-linked A4V SOD1 rapidly monomerizes and partially unfolds in an external electric field (of physiological strength), without loss of metal ions, exposure to disulfide-reducing agents, or Joule heating.	Hydrogen	30-38	superoxide dismutase 1	Homo sapiens	154-158
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Hydrogen	70-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Hydrogen	70-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Hydrogen	365-367	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
26323791-1	2015	A one-photon two-electron process was made possible in photocatalytic H2 evolution from ascorbic acid with a cobalt(II) chlorin complex [Co(II)(Ch)] via electron transfer from ascorbate to the excited state of [Ru(bpy)3](2+) followed by electron transfer from [Ru(bpy)3](+) to Co(II)(Ch) with proton to give the hydride complex, which reacts with proton to produce H2.	Hydrogen	365-367	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	277-283
26493911-9	2015	In dynamics, the component of muk(t) parallel to Ek (loc)(t) changes on the time scale of the hydrogen bonds ~5 ps, while its smaller perpendicular component undergoes librational motions on time scales of 0.01 ps.	Hydrogen	94-102	mitogen-activated protein kinase kinase kinase 12	Homo sapiens	30-33
26440750-3	2015	In the present study, hydrogen exchange mass spectrometry (HX MS) was used to study conformational changes in downregulated Hck that result from Nef binding, as well as the impact of DFP-4AB on these changes.	Hydrogen	22-30	S100 calcium binding protein B	Homo sapiens	145-148
26320621-3	2015	The docking results showed that the catechol diether moiety of compound 8 played a key role to form integral hydrogen bonds with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4.	Hydrogen	109-117	phosphodiesterase 4B	Homo sapiens	129-134
26320621-3	2015	The docking results showed that the catechol diether moiety of compound 8 played a key role to form integral hydrogen bonds with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4.	Hydrogen	109-117	phosphodiesterase 4A	Homo sapiens	129-133
27132459-0	2015	[Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with traumatic brain injury].	Hydrogen	12-20	NFE2 like bZIP transcription factor 2	Rattus norvegicus	53-58
27132459-1	2015	OBJECTIVE: To investigate the effects of hydrogen rich water on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and oxidative stress in rats with traumatic brain injury (TBI).	Hydrogen	41-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	82-125
27132459-1	2015	OBJECTIVE: To investigate the effects of hydrogen rich water on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and oxidative stress in rats with traumatic brain injury (TBI).	Hydrogen	41-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	127-131
27132459-20	2015	CONCLUSIONS: Hydrogen rich water can up-regulate the expression of Nrf2, and reduce oxidative damage of traumatic brain injury in rats.	Hydrogen	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	67-71
26485399-8	2015	Modeling of the binding site of CYP3A4 revealed a combination of three types of interactions: hydrophobic interactions, electrostatic interactions and hydrogen bonds.	Hydrogen	151-159	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	32-38
26337042-6	2015	By using gene-knockdown techniques with bioimaging, the H2 S biogenesis was found to be majorly cystathionine beta-synthase (CBS)-dependent.	Hydrogen	56-58	cystathionine beta-synthase	Homo sapiens	96-123
26471964-5	2015	The hydrogenation leads to Nd4Mg80Ni8 decomposing into NdH2.61-MgH2-Mg2NiH0.3 nanocomposites, where the high density phase boundaries provide a great deal of hydrogen atoms diffusion channels and nucleation sites of hydrides, which greatly enhances the hydriding/dehydriding (H/D) properties.	Hydrogen	4-12	DExH-box helicase 9	Homo sapiens	55-59
26381710-9	2015	Importantly, the hydrogen bond donor strength is, on average, higher in ABCG2 than in ABCB1, which explains the higher measured affinity of allocrite for ABCG2.	Hydrogen	17-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	72-77
32262635-6	2015	Furthermore, gelatin and basic fibroblast growth factor (bFGF) were immobilized in the cellulose sponge through hydrogen bonding to retain their inherent biocompatibility, leading to excellent repairing efficacy.	Hydrogen	112-120	fibroblast growth factor 2	Homo sapiens	25-55
32262635-6	2015	Furthermore, gelatin and basic fibroblast growth factor (bFGF) were immobilized in the cellulose sponge through hydrogen bonding to retain their inherent biocompatibility, leading to excellent repairing efficacy.	Hydrogen	112-120	fibroblast growth factor 2	Homo sapiens	57-61
26351779-4	2015	DFT calculations were performed on the reacting complex of LGa with propargyl alcohol and show an OHGa hydrogen bond as the first interaction between the reagents.	Hydrogen	103-111	glutaminase 2	Homo sapiens	59-62
26381710-9	2015	Importantly, the hydrogen bond donor strength is, on average, higher in ABCG2 than in ABCB1, which explains the higher measured affinity of allocrite for ABCG2.	Hydrogen	17-25	ATP binding cassette subfamily B member 1	Homo sapiens	86-91
26381710-9	2015	Importantly, the hydrogen bond donor strength is, on average, higher in ABCG2 than in ABCB1, which explains the higher measured affinity of allocrite for ABCG2.	Hydrogen	17-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	154-159
26443076-4	2015	Further X-ray structure and SAR analyses revealed that the potencies of the designed inhibitors were partly attributable to additional water-mediated hydrogen bond networks formed by an unexpected buried water between hDHODH and the 2-(2-methylenehydrazinyl)thiazole scaffold.	Hydrogen	150-158	dihydroorotate dehydrogenase (quinone)	Homo sapiens	218-224
26460611-7	2015	Structure-based mutational analysis shows that distinct hydrogen bond networks of four FBG3 loops, i.e., beta2-beta3, beta5-beta6, beta7-beta8, and beta9-beta10, prevent the formation of the carbohydrate-binding pocket shown in Fbs1.	Hydrogen	56-64	F-box protein 2	Homo sapiens	228-232
26443076-5	2015	This work not only elucidates promising scaffolds targeting hDHODH for the treatment of rheumatoid arthritis, but also demonstrates that the water-mediated hydrogen bond interaction is an important factor in molecular design and optimization.	Hydrogen	156-164	dihydroorotate dehydrogenase (quinone)	Homo sapiens	60-66
26293246-5	2015	Stabilization of the B-Raf(WT) KD was confirmed by hydrogen/deuterium exchange MS and molecular dynamics simulations.	Hydrogen	51-59	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	21-26
26271894-0	2015	Hydrogen-rich water attenuates amyloid beta-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.	Hydrogen	0-8	forkhead box O3	Homo sapiens	95-101
26269596-3	2015	In the water hydrogen bond network the neurokinin-1 has a unique Glu residue instead of the highly conserved AspII:10 (2.50).	Hydrogen	13-21	tachykinin precursor 1	Homo sapiens	39-51
26232728-4	2015	In the early phase (~1h) after a hemorrhage and RBC resuscitation, hepatic CYP protein levels were significantly decreased with increasing hepatic free heme levels, but were maintained by a pre-treatment of gadolinium chloride (GdCl3), a Kupffer cell inhibitor, and Trolox, an anti-oxidant agent, as well as CO-RBC resuscitation.	Hydrogen	21-23	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	75-78
26431526-11	2015	Finally, recruitment of immuno-reactive GLUT12 to the muscle plasma membrane was increased following 1h of intraperitoneal insulin administration (compared to a control fasted state).	Hydrogen	101-103	insulin	Gallus gallus	123-130
26116703-5	2015	We discovered an intramolecular hydrogen bond (Gln188-Nepsilon2-H: Glu196-Oepsilon2, 2 A, 124 ) within the large extracellular loop (LEL) of mCD81 and a salt bridge (Lys188-Nzeta: Asp196-Odelta2, 2.4 A) within agmCD81-LEL between residues 188 and 196.	Hydrogen	32-40	CD81 antigen	Mus musculus	141-146
25750008-11	2015	Compared with the control group, the hydrogen group had a statistically significantly lower expression of IL-1beta (P = 0.0317), IL-6 (P = 0.0159), IL-8 (P = 0.0195) and TNF-alpha (P = 0.0159).	Hydrogen	37-45	interleukin 6	Homo sapiens	129-133
25750008-11	2015	Compared with the control group, the hydrogen group had a statistically significantly lower expression of IL-1beta (P = 0.0317), IL-6 (P = 0.0159), IL-8 (P = 0.0195) and TNF-alpha (P = 0.0159).	Hydrogen	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
25750008-11	2015	Compared with the control group, the hydrogen group had a statistically significantly lower expression of IL-1beta (P = 0.0317), IL-6 (P = 0.0159), IL-8 (P = 0.0195) and TNF-alpha (P = 0.0159).	Hydrogen	37-45	tumor necrosis factor	Homo sapiens	170-179
25750008-11	2015	Compared with the control group, the hydrogen group had a statistically significantly lower expression of IL-1beta (P = 0.0317), IL-6 (P = 0.0159), IL-8 (P = 0.0195) and TNF-alpha (P = 0.0159).	Hydrogen	37-45	interleukin 1 beta	Homo sapiens	106-114
26117323-10	2015	Also, H(2) increased Nrf2 (NF-E2-related factor-2, an important factor in antioxidant signaling) activation and Nrf2 small interfering RNA abolished the protective effect of H(2) on ox-LDL-induced cellular ROS production.	Hydrogen	6-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
26117323-10	2015	Also, H(2) increased Nrf2 (NF-E2-related factor-2, an important factor in antioxidant signaling) activation and Nrf2 small interfering RNA abolished the protective effect of H(2) on ox-LDL-induced cellular ROS production.	Hydrogen	6-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	27-49
26117323-10	2015	Also, H(2) increased Nrf2 (NF-E2-related factor-2, an important factor in antioxidant signaling) activation and Nrf2 small interfering RNA abolished the protective effect of H(2) on ox-LDL-induced cellular ROS production.	Hydrogen	174-178	nuclear factor, erythroid derived 2, like 2	Mus musculus	112-116
26117323-11	2015	The inhibitory effects of H(2) on the apoptosis of macrophage-derived foam cells, which take effect by suppressing the activation of the ERS pathway and by activating the Nrf2 antioxidant pathway, might lead to an improvement in atherosclerotic plaque stability.	Hydrogen	26-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	171-175
25820467-9	2015	We found that H2 clearly inhibited hyperalgesia and allodynia in neuropathic pain and also attenuated the pro-inflammatory cytokines TNF-alpha, IL-1beta, and high-mobility group box (HMGB) 1.	Hydrogen	14-16	tumor necrosis factor	Rattus norvegicus	133-142
25820467-9	2015	We found that H2 clearly inhibited hyperalgesia and allodynia in neuropathic pain and also attenuated the pro-inflammatory cytokines TNF-alpha, IL-1beta, and high-mobility group box (HMGB) 1.	Hydrogen	14-16	interleukin 1 beta	Rattus norvegicus	144-152
26520956-4	2015	The developed LARM-PSS switch is capable to hold voltage up to 25 kV at gas pressure between 10 and 50 Pa for hydrogen.	Hydrogen	110-118	PSS	Homo sapiens	19-22
26208753-5	2015	The putative LcBCA2 protein contained a RING-H2 motif at C terminal.	Hydrogen	45-47	E3 ubiquitin-protein ligase RNF115-like	Larimichthys crocea	13-19
26211916-4	2015	Extensive mutational analysis combined with kinetic and CO-FT-IR spectroscopic investigation led to the hypothesis that Lba depended on weakened electrostatic interaction between distal HisE7 and bound ligand achieved by invoking B10Tyr, which itself hydrogen bonds with HisE7 thus restricting it in a single conformation detrimental to Mb-like strong electrostatic interaction.	Hydrogen	251-259	leghemoglobin A	Glycine max	120-123
26211916-6	2015	The investigation supports the presence of at least two major conformations of HisE7 in Lba brought about by imidazole ring flip, one of which makes hydrogen bonds effectively with B10Tyr affecting the former"s ability to stabilize bound ligand, while the other does not.	Hydrogen	149-157	leghemoglobin A	Glycine max	88-91
26211916-8	2015	Thus, it appears that TyrB10 limits the conformational freedom of distal His in Lba, tuning down ligand dissociation rate constant by reducing the strength of hydrogen bonding to bound ligand, which the freedom of distal His of Mb allows.	Hydrogen	159-167	leghemoglobin A	Glycine max	80-83
26374839-8	2015	These results suggest that specific binding of cellular RNAs by FMRP may involve hydrogen bonding with RNA duplexes and that RNA duplex recognition can be a characteristic RNA binding feature for RGG motifs in other proteins.	Hydrogen	81-89	fragile X messenger ribonucleoprotein 1	Homo sapiens	64-68
26351728-5	2015	A clear structure-activity relationship was observed with respect to JAK1 selectivity; this highlighted the importance of hydrogen bond donors at both N(1) and R2 positions located within a specific distance from the benzimidazole core.	Hydrogen	122-130	Janus kinase 1	Homo sapiens	69-73
26416382-4	2015	Characteristically, phosphonic acid-substituted at imide position of NDIs possess two important properties resulting in the formation of controlled flower-like nanostructures: (i) the aromatic core of the NDI which is designed to optimize the dispersive interactions (pi-pi stacking and van der Waals interactions) between the cores within a construct and (ii) phosphonic acid of NDI interact with malamine through molecular recognition i.e. strong hydrogen-bonding (H-bonding).	Hydrogen	449-457	arginine vasopressin receptor 2	Homo sapiens	69-72
26416382-4	2015	Characteristically, phosphonic acid-substituted at imide position of NDIs possess two important properties resulting in the formation of controlled flower-like nanostructures: (i) the aromatic core of the NDI which is designed to optimize the dispersive interactions (pi-pi stacking and van der Waals interactions) between the cores within a construct and (ii) phosphonic acid of NDI interact with malamine through molecular recognition i.e. strong hydrogen-bonding (H-bonding).	Hydrogen	449-457	arginine vasopressin receptor 2	Homo sapiens	205-208
26317651-6	2015	Furthermore, apart from a substrate binding domain, afatinib could also bind to an ATP binding domain of ABCB1 through forming hydrogen bonds with Gly533, Gly534, Lys536 and Ala560 sites.	Hydrogen	127-135	ATP binding cassette subfamily B member 1	Homo sapiens	105-110
26337615-4	2015	Atomistic simulations reveal that hydrogen bond formation and the mean lifetime of hydration waters of the poly(ethylene oxide) (or PEO) groups are location-dependent in the HEUR micelle, with PEO groups immediately adjacent to the C16 groups forming the fewest hydrogen bonds with water and having hydration waters with longer lifetimes than those of the PEO groups located further away from the C16 groups.	Hydrogen	262-270	twinkle mtDNA helicase	Homo sapiens	132-135
26337615-4	2015	Atomistic simulations reveal that hydrogen bond formation and the mean lifetime of hydration waters of the poly(ethylene oxide) (or PEO) groups are location-dependent in the HEUR micelle, with PEO groups immediately adjacent to the C16 groups forming the fewest hydrogen bonds with water and having hydration waters with longer lifetimes than those of the PEO groups located further away from the C16 groups.	Hydrogen	34-42	twinkle mtDNA helicase	Homo sapiens	193-196
26337615-4	2015	Atomistic simulations reveal that hydrogen bond formation and the mean lifetime of hydration waters of the poly(ethylene oxide) (or PEO) groups are location-dependent in the HEUR micelle, with PEO groups immediately adjacent to the C16 groups forming the fewest hydrogen bonds with water and having hydration waters with longer lifetimes than those of the PEO groups located further away from the C16 groups.	Hydrogen	34-42	twinkle mtDNA helicase	Homo sapiens	193-196
26291200-4	2015	The overall hydrogen isotope analysis via GC-Cr/HTC-isotope ratio mass spectrometry (IRMS) achieved a precision of better than +- 5 mUr along the VSMOW-SLAP scale.	Hydrogen	12-20	Src like adaptor	Homo sapiens	152-156
26342370-3	2015	The PdH3 (-) anionic complex is made up of a PdH(-) sub-anion ligated by a H2 molecule, in which the H-H bond is lengthened compared to free H2.	Hydrogen	75-77	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	4-7
26299825-7	2015	Molecular docking analysis of the title compounds with the second deacetylase domain of HDAC6 displayed high degree of shape complementarity to the binding site of the enzyme, forming multiple molecular interactions in the hydrophobic region as well as a hydrogen bond to the phenol side-chain of Tyr-782.	Hydrogen	255-263	histone deacetylase 6	Homo sapiens	88-93
26308263-12	2015	MD simulations revealed hydrophobic contacts and hydrogen bonds as the main interactions between ER and the estrogenic compounds.	Hydrogen	49-57	estrogen receptor 1	Homo sapiens	97-99
26305973-4	2015	Insulin-stimulated rates of muscle glucose uptake were reduced by 25% (P&lt;0.01) in the elderly subjects and were associated with ~70% (P&lt;0.04) increase in IMCL, assessed by 1H magnetic resonance spectroscopy.	Hydrogen	178-180	insulin	Homo sapiens	0-7
26342370-3	2015	The PdH3 (-) anionic complex is made up of a PdH(-) sub-anion ligated by a H2 molecule, in which the H-H bond is lengthened compared to free H2.	Hydrogen	141-143	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	4-7
26342370-5	2015	The H2 binding energy to PdH(-) is calculated to be 89.2 kJ/mol, which is even higher than that between CO and Pd.	Hydrogen	4-6	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	25-28
26340563-7	2015	Furthermore, we observed several important differences in the interactions with amino acid residues, in particular that avibactam forms hydrogen bonds to S130 in KPC-2 but not in SHV-1, that can possibly explain some of the different kinetic constants of inhibition.	Hydrogen	136-144	carbapenem-hydrolyzing beta-lactamase KPC-2	Klebsiella pneumoniae	162-167
25962664-0	2015	Hydrogen gas production is associated with reduced interleukin-1beta mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients.	Hydrogen	0-8	interleukin 1 beta	Homo sapiens	51-68
25962664-8	2015	However, the changes in total hydrogen gas production from day 1 to day 2 were closely and inversely associated with the changes in peripheral blood IL-1beta mRNA levels.	Hydrogen	30-38	interleukin 1 beta	Homo sapiens	149-157
25962664-9	2015	Our results suggest that an increase in hydrogen gas production is inversely associated with a reduction of the peripheral blood IL-1beta mRNA level after a single dose of acarbose in Japanese type 2 diabetic patients.	Hydrogen	40-48	interleukin 1 beta	Homo sapiens	129-137
26237575-3	2015	Four different reactions have been studied in this work: CsO + H2 = CsOH + H (R1), Cs + HI = CsI + H (R2), CsI + H2O = CsOH + HI (R3), and CsI + OH = CsOH + I (R4).	Hydrogen	63-65	twist family bHLH transcription factor 1	Homo sapiens	57-60
26253656-0	2015	Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway.	Hydrogen	10-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	109-113
25662956-8	2015	Furthermore, the lung injury score determined by histopathology, the cell apoptotic index, and the caspase-3 protein expression in lung grafts were decreased after hydrogen treatment, and the static pressure-volume curve of lung graft was improved by hydrogen inflation.	Hydrogen	164-172	caspase 3	Homo sapiens	99-108
25662956-8	2015	Furthermore, the lung injury score determined by histopathology, the cell apoptotic index, and the caspase-3 protein expression in lung grafts were decreased after hydrogen treatment, and the static pressure-volume curve of lung graft was improved by hydrogen inflation.	Hydrogen	251-259	caspase 3	Homo sapiens	99-108
26193680-4	2015	LSZ could interact with MAS via hydrogen bonds and electrostatic forces, resulting in the formation of intercalated nanocomposites.	Hydrogen	32-40	lysozyme	Homo sapiens	0-3
26253656-0	2015	Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway.	Hydrogen	10-18	heme oxygenase 1	Mus musculus	114-118
26253656-4	2015	Here, we hypothesized that H2 attenuates endothelial injury and inflammation via an Nrf2-mediated HO-1 pathway during sepsis.	Hydrogen	27-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
26253656-4	2015	Here, we hypothesized that H2 attenuates endothelial injury and inflammation via an Nrf2-mediated HO-1 pathway during sepsis.	Hydrogen	27-29	heme oxygenase 1	Mus musculus	98-102
26253656-9	2015	H2 could suppress the release of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1), and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and high-mobility group box 1 protein (HMGB1).	Hydrogen	0-2	tumor necrosis factor	Mus musculus	202-235
26253656-9	2015	H2 could suppress the release of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1), and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and high-mobility group box 1 protein (HMGB1).	Hydrogen	0-2	interleukin 1 beta	Mus musculus	237-259
26253656-10	2015	Furthermore, H2 could elevate anti-inflammatory cytokine IL-10 levels in LPS-stimulated HUVECs and in lung tissue from CLP mice.	Hydrogen	13-15	interleukin 10	Mus musculus	57-62
26253656-11	2015	H2 enhanced HO-1 expression and activity in vitro and in vivo.	Hydrogen	0-2	heme oxygenase 1	Mus musculus	12-16
26253656-12	2015	HO-1 inhibition reversed the regulatory effects of H2 on cell adhesion molecules and inflammatory factors.	Hydrogen	51-53	heme oxygenase 1	Mus musculus	0-4
26253656-13	2015	H2 regulated endothelial injury and the inflammatory response via Nrf2-mediated HO-1 levels.	Hydrogen	0-2	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
26253656-13	2015	H2 regulated endothelial injury and the inflammatory response via Nrf2-mediated HO-1 levels.	Hydrogen	0-2	heme oxygenase 1	Mus musculus	80-84
26253656-14	2015	These results suggest that H2 could suppress excessive inflammatory responses and endothelial injury via an Nrf2/HO-1 pathway.	Hydrogen	27-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-112
26253656-14	2015	These results suggest that H2 could suppress excessive inflammatory responses and endothelial injury via an Nrf2/HO-1 pathway.	Hydrogen	27-29	heme oxygenase 1	Mus musculus	113-117
26315260-7	2015	The diffusive hydrogen in the P2(1)/c superionic phase shows strong anisotropic behaviour and forms a quasi-two-dimensional liquid.	Hydrogen	14-22	cyclin dependent kinase inhibitor 1A	Homo sapiens	30-35
26239697-5	2015	Meanwhile, the obtained binding constant and thermodynamic parameters on complex-HSA interaction showed that the types of interaction force of Cu(II)-ATA and HSA were hydrogen bonding, van der Waals and electrostatic.	Hydrogen	167-175	albumin	Homo sapiens	81-84
26239697-5	2015	Meanwhile, the obtained binding constant and thermodynamic parameters on complex-HSA interaction showed that the types of interaction force of Cu(II)-ATA and HSA were hydrogen bonding, van der Waals and electrostatic.	Hydrogen	167-175	albumin	Homo sapiens	158-161
26239697-8	2015	Furthermore, amino group and attractive electrostatic interaction of Cu(II)-ATA greatly contributed to the hydrogen bonding, van der Waals and electrostatic interaction between Cu(II)-ATA and HSA, as confirmed by experimental data.	Hydrogen	107-115	albumin	Homo sapiens	177-195
26035067-4	2015	The aim of the present study was to investigate the protective effects of hydrogen-rich medium (HM) on high glucose (HG)-mediated oxidative stress, PARP-1 activation and the apoptosis of Schwann cells (SCs) in vitro.	Hydrogen	74-82	poly(ADP-ribose) polymerase 1	Homo sapiens	148-154
26425434-6	2015	Other reaction paths-involving solid solutions, metastable distorted phases, and phases with low hydrogen content-were recently reported for TiH2 and Mg2FeH6, Mg2CoH5 and Mg2NiH4.	Hydrogen	97-105	RuvB like AAA ATPase 2	Homo sapiens	141-145
26716330-2	2015	In this work, we have demonstrated the preparation of new multiwall carbon nanotube (MWNT) incorporate multi-responsive (pH and thermal) gels (MWNT-IPN-MRG) though network formation with functional macromolecules that interact each other via hydrogen bonds, covalent networking and temporary associative forces.	Hydrogen	242-250	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	152-155
26325194-7	2015	Using hydrogen-deuterium exchange mass spectrometry (HDX-MS), we showed that both Chd64 proteins have disordered tails that outflank the globular core.	Hydrogen	6-14	Chd64	Drosophila melanogaster	82-87
26275107-3	2015	Crystallographic analysis of Pim-1 bound to hispidulin reveals a binding mode distinct from that of quercetin, suggesting that the binding potency of flavonoids is determined by their hydrogen-bonding interactions with the hinge region of the kinase.	Hydrogen	184-192	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	29-34
26245381-10	2015	In this compacted mRNA conformation, stop codons are favoured by a hydrogen-bonding network formed between rRNA and essential eRF1 residues that constrains the identity of the bases.	Hydrogen	67-75	eukaryotic translation termination factor 1	Homo sapiens	126-130
26267290-8	2015	It was shown that the presence of hydrogen atoms in carbon plasma and UV radiation accelerate the C10(st)   C10(rg) transition and thus suppress the C20 fullerene formation.	Hydrogen	34-42	homeobox C10	Homo sapiens	98-101
26267290-8	2015	It was shown that the presence of hydrogen atoms in carbon plasma and UV radiation accelerate the C10(st)   C10(rg) transition and thus suppress the C20 fullerene formation.	Hydrogen	34-42	homeobox C10	Homo sapiens	108-111
26148543-2	2015	According to the proposed reaction mechanism and DFT calculations, complexes and are generated from an 18e(-) intermediate [Tp(Me2)Ir(C2H4)(acac)(C2H3)] () which undergoes either hydrogen insertion or beta-hydride elimination followed by the subsequent loss of a molecule of ethylene.	Hydrogen	179-187	malic enzyme 2	Homo sapiens	127-130
25978068-8	2015	Computational docking suggests the importance of discrete hydrogen bonding and aromatic interactions as determinants of AM3677"s topology within the ligand-binding pocket of active-state hCB1R.	Hydrogen	58-66	cannabinoid receptor 1	Homo sapiens	187-192
26289479-2	2015	Using nuclear magnetic resonance (NMR) spectroscopy, x-ray crystallography and hydrogen/deuterium exchange (HDX) mass spectrometry, here we show an allosteric mechanism through which RXR co-operates with a permissive dimer partner, peroxisome proliferator-activated receptor (PPAR)-gamma, while rendered generally unresponsive by a non-permissive dimer partner, thyroid hormone (TR) receptor.	Hydrogen	79-87	peroxisome proliferator activated receptor gamma	Homo sapiens	232-287
26217939-4	2015	Furthermore, the CoFe2O4 NPs-on-CFP electrodes also exhibit hydrogen evolution reaction (HER) performance, which is considerably higher than that of bare CFP, acting as a bifunctional electrocatalyst.	Hydrogen	60-68	complement factor properdin	Homo sapiens	32-35
26396888-3	2015	In addition, weak C-H N and C-H O hydrogen bonds, together with weak pi-pi inter-actions, with centroid-centroid distances of 3.6560 (5) and 3.6295 (5) A, connect the chains, forming a two-dimensional network parallel to (100).	Hydrogen	34-42	nuclear receptor subfamily 4 group A member 3	Homo sapiens	18-31
26202861-5	2015	Owing to the spatial effect and hydrogen bond between the AA and the groups on the N-CNP surface, excellent sensitivity and selectivity for AA detecting was obtained in a wide linear relationship from 0.2 muM to 150 muM.	Hydrogen	32-40	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	85-88
26273320-2	2015	This study presents a proof-of-concept system in which hydrogen can be produced in an MEC powered by theoretically predicated energy from pressure-retarded osmosis (PRO).	Hydrogen	55-63	C-C motif chemokine ligand 28	Homo sapiens	86-89
26213196-8	2015	Combined experimental and theoretical study suggest a formal Co(II)-hydride species as a key intermediate that triggers H2 generation.	Hydrogen	120-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
26273320-7	2015	The amount of the predicated energy was applied to the MEC by a power supply, which drove the MEC to remove 93.7 % of the organic compounds and produce 32.8 mL of H2 experimentally.	Hydrogen	163-165	C-C motif chemokine ligand 28	Homo sapiens	55-58
26273320-7	2015	The amount of the predicated energy was applied to the MEC by a power supply, which drove the MEC to remove 93.7 % of the organic compounds and produce 32.8 mL of H2 experimentally.	Hydrogen	163-165	C-C motif chemokine ligand 28	Homo sapiens	94-97
26273320-10	2015	With a higher external voltage, the MEC energy consumption would exceed the PRO energy production, leading to negative effects on both organic removal and hydrogen production.	Hydrogen	155-163	C-C motif chemokine ligand 28	Homo sapiens	36-39
26273320-11	2015	CONCLUSIONS: The PRO-MEC system holds great promise in addressing water-energy nexus through organic removal, hydrogen production, and water recovery: (1) the PRO unit can reduce the volume of wastewater and extract clean water; (2) the PRO effluents can be further treated by the MEC; and (3) the osmotic energy harvested from the PRO unit can be applied to the MEC for sustainable bioelectrochemical hydrogen production.	Hydrogen	110-118	C-C motif chemokine ligand 28	Homo sapiens	21-24
26273320-11	2015	CONCLUSIONS: The PRO-MEC system holds great promise in addressing water-energy nexus through organic removal, hydrogen production, and water recovery: (1) the PRO unit can reduce the volume of wastewater and extract clean water; (2) the PRO effluents can be further treated by the MEC; and (3) the osmotic energy harvested from the PRO unit can be applied to the MEC for sustainable bioelectrochemical hydrogen production.	Hydrogen	402-410	C-C motif chemokine ligand 28	Homo sapiens	21-24
26273320-11	2015	CONCLUSIONS: The PRO-MEC system holds great promise in addressing water-energy nexus through organic removal, hydrogen production, and water recovery: (1) the PRO unit can reduce the volume of wastewater and extract clean water; (2) the PRO effluents can be further treated by the MEC; and (3) the osmotic energy harvested from the PRO unit can be applied to the MEC for sustainable bioelectrochemical hydrogen production.	Hydrogen	402-410	C-C motif chemokine ligand 28	Homo sapiens	281-284
26273320-11	2015	CONCLUSIONS: The PRO-MEC system holds great promise in addressing water-energy nexus through organic removal, hydrogen production, and water recovery: (1) the PRO unit can reduce the volume of wastewater and extract clean water; (2) the PRO effluents can be further treated by the MEC; and (3) the osmotic energy harvested from the PRO unit can be applied to the MEC for sustainable bioelectrochemical hydrogen production.	Hydrogen	402-410	C-C motif chemokine ligand 28	Homo sapiens	281-284
26266340-3	2015	A prominent structural feature, which separates the P-3 structure from previously observed/predicted SiH4 structures, is that a fraction of hydrogen leaves the Si-H bonding environment and forms segregated H2 units.	Hydrogen	140-148	exosome component 10	Homo sapiens	52-55
26266340-6	2015	Structural stability of the P-3 structure is attributed to the electron-deficient multicenter Si-H-Si interactions when neighboring silicon atoms are linked together through a common hydrogen atom.	Hydrogen	183-191	exosome component 10	Homo sapiens	28-31
26153025-2	2015	A multistep functionalization strategy was developed on a crystalline silicon surface: a carboxylic acid-terminated monolayer was grafted onto a hydrogen-terminated silicon surface by photochemical hydrosilylation, and then AChE was covalently attached through amide bonds using an activation EDC/NHS process.	Hydrogen	145-153	acetylcholinesterase (Cartwright blood group)	Homo sapiens	224-228
25753971-9	2015	Hydrogen bond analysis and binding free energy calculation revealed that SGLT2 binding complex was more stable and favorable than SGLT1 complex, which was highly correlated with the experimental results.	Hydrogen	0-8	solute carrier family 5 member 1	Homo sapiens	130-135
26204267-5	2015	Our calculations demonstrate that the hydricity of the metal-hydride intermediate generated by H2 splitting dictates the nature of the RDS for the Fe(II) and Co(III) systems, while the RDS for the Ru(II) catalyst appears to be ambiguous.	Hydrogen	95-97	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	158-165
26200797-8	2015	Three imidazole groups of fac-[Fe(II)(HL(n-Pr))3](2+) are hydrogen-bonded to three Cl(-) ions.	Hydrogen	58-66	FA complementation group C	Homo sapiens	26-29
26048582-3	2015	Stilbene synthase-like (STS) enzymes are unique in the type III PKS class as they possess a hydrogen bonding network, furnishing them with thioesterase-like properties, resulting in aldol condensation of the polyketide intermediates formed.	Hydrogen	92-100	stilbene synthase 3	Vitis vinifera	0-22
26079999-0	2015	Active Site Dynamical Effects in the Hydrogen Transfer Rate-limiting Step in the Catalysis of Linoleic Acid by Soybean Lipoxygenase-1 (SLO-1): Primary and Secondary Isotope Contributions.	Hydrogen	37-45	seed linoleate 13S-lipoxygenase-1	Glycine max	119-133
26201548-0	2015	Hydrogen abstraction mechanisms and reaction rates of toluene+NO3.	Hydrogen	0-8	NBL1, DAN family BMP antagonist	Homo sapiens	62-65
26201548-1	2015	The hydrogen abstraction reaction mechanisms of toluene molecule by NO3 radical were investigated theoretically with quantum chemistry and reaction kinetics.	Hydrogen	4-12	NBL1, DAN family BMP antagonist	Homo sapiens	68-71
26006043-8	2015	Pre-treatment of cells with 0.5 or 5mM NAC at 0.5 or 1h and its subsequent washout before MeHg addition suppressed MCP-1 and IL-6 cytokine expressions.	Hydrogen	53-55	interleukin 6	Homo sapiens	125-129
25987608-4	2015	The increased AGT formation and secretion into the proximal tubular lumen leads to local formation of Ang II, which stimulates proximal transporters such as the sodium/hydrogen exchanger.	Hydrogen	168-176	angiotensinogen	Homo sapiens	14-17
25987608-4	2015	The increased AGT formation and secretion into the proximal tubular lumen leads to local formation of Ang II, which stimulates proximal transporters such as the sodium/hydrogen exchanger.	Hydrogen	168-176	angiotensinogen	Homo sapiens	102-108
26079999-1	2015	Using ab initio molecular dynamics (AIMD) simulations that facilitate the treatment of rare events, we probe the active site participation in the rate-determining hydrogen transfer step in the catalytic oxidation of linoleic acid by soybean lipoxygenase-1 (SLO-1).	Hydrogen	163-171	seed linoleate 13S-lipoxygenase-1	Glycine max	241-255
26233123-4	2015	The corresponding digraphs of generated hydrogen bond matrices are used as the theoretical framework to obtain all the topology-distinct local minima for (HF)n (n &lt;= 6), at the level of MP2/6-31G**(d, p) of ab initio MO method and B3LYP/6-31G**(d, p) of density functional theory method.	Hydrogen	40-48	major intrinsic protein of lens fiber	Homo sapiens	189-194
26009165-6	2015	Strategy B was to replace the hydroxyl of C-6 with other substituents based on the assumption that the intra-molecular hydrogen bond could increase the electrophilicity of C-10.	Hydrogen	119-127	homeobox C10	Homo sapiens	172-176
32262564-8	2015	1H-NMR before and after aggregation revealed the conformational changes taking place in the lysozyme: during aggregation, lysozyme is transformed into a random coil conformation, thus losing its secondary structure.	Hydrogen	0-2	lysozyme	Homo sapiens	92-100
32262564-8	2015	1H-NMR before and after aggregation revealed the conformational changes taking place in the lysozyme: during aggregation, lysozyme is transformed into a random coil conformation, thus losing its secondary structure.	Hydrogen	0-2	lysozyme	Homo sapiens	122-130
28793435-5	2015	They provide an initial turnover frequency (TOF) value of 80 min-1 in hydrogen generation from the hydrolysis of ammonia-borane at room temperature.	Hydrogen	70-78	CD59 molecule (CD59 blood group)	Homo sapiens	61-66
26112884-0	2015	Modeling Suggests TRPC3 Hydrogen Bonding and Not Phosphorylation Contributes to the Ataxia Phenotype of the Moonwalker Mouse.	Hydrogen	24-32	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	18-23
25919404-0	2015	The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition.	Hydrogen	25-33	aldo-keto reductase family 1 member B	Homo sapiens	61-77
25919404-1	2015	The effect of halogen-to-hydrogen bond substitution on the binding energetics and biological activity of a human aldose reductase inhibitor has been studied using X-ray crystallography, IC50 measurements, advanced binding free energy calculations, and simulations.	Hydrogen	25-33	aldo-keto reductase family 1 member B	Homo sapiens	113-129
26077728-0	2015	Exfoliated carbon nitride nanosheets decorated with NiS as an efficient noble-metal-free visible-light-driven photocatalyst for hydrogen evolution.	Hydrogen	128-136	solute carrier family 5 member 5	Homo sapiens	52-55
26077728-1	2015	A binary composite composed of two dimensional (2D) ultrathin carbon nitride (C3N4) nanosheets and NiS nanoparticles was synthesized and applied as a noble-metal-free photocatalyst for hydrogen evolution under visible light irradiation.	Hydrogen	185-193	solute carrier family 5 member 5	Homo sapiens	99-102
26270136-6	2015	The cytokines assessment showed that IL-6 levels were increased in the RIPC group after 1h of reperfusion, in comparison to the I/R group (p&lt;0.05).	Hydrogen	88-90	interleukin 6	Rattus norvegicus	37-41
25903134-4	2015	Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and SPR interaction analysis on a library of lysine replacement variants as two independent approaches, we demonstrate that the interaction between factor VIII (FVIII) and LRP1 occurs over an extended surface containing multiple lysine residues.	Hydrogen	6-14	LDL receptor related protein 1	Homo sapiens	233-237
26010498-2	2015	GRL-5010A and GRL-4410A were designed to introduce hydrogen bond interactions with the flexible flaps of the PR by incorporating gem-difluorines and alkoxy, respectively, at the C4 position of the bis-THF of darunavir.	Hydrogen	51-59	nuclear receptor subfamily 3 group C member 1	Homo sapiens	0-3
25863345-7	2015	Binding of APP to the BACE1 cavity shifts the equilibrium towards a stable complex stabilized by strong electrostatic surface complementarity along with several van der Waals and hydrogen bonding interactions.	Hydrogen	179-187	beta-secretase 1	Homo sapiens	22-27
25836764-4	2015	This early activation at 1h appeared to be independent of receptor (Lrp5/6) mediated activation as it occurred in the presence of the inhibitors sclerostin and/or Dkk1.	Hydrogen	25-27	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	163-167
26003800-0	2015	Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway.	Hydrogen	0-8	BCL2, apoptosis regulator	Rattus norvegicus	95-100
26003800-0	2015	Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway.	Hydrogen	0-8	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	111-116
26003800-2	2015	This study focused on the influence of hydrogen-rich saline treatment on apoptosis pathway of ASK-1/JNK and Bcl-2/Bax radio in I/R injury of skin flaps.	Hydrogen	39-47	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	94-99
26003800-2	2015	This study focused on the influence of hydrogen-rich saline treatment on apoptosis pathway of ASK-1/JNK and Bcl-2/Bax radio in I/R injury of skin flaps.	Hydrogen	39-47	BCL2, apoptosis regulator	Rattus norvegicus	108-113
26051605-4	2015	Molecular docking revealed that compound bound to the interface region of TLR1-TLR2 by forming two hydrogen bonds with residues lining the binding site.	Hydrogen	99-107	toll like receptor 1	Homo sapiens	74-78
26051605-4	2015	Molecular docking revealed that compound bound to the interface region of TLR1-TLR2 by forming two hydrogen bonds with residues lining the binding site.	Hydrogen	99-107	toll like receptor 2	Homo sapiens	79-83
26031665-5	2015	On the other hand, receptor 10(2+) 2 BF4(-) (4-CH3O-C6H4) only displays combined Csp2-H/anion-pi interactions between the two arms of the receptors and the bound anion rather than triazolium (CH)(+)   anion hydrogen bonding.	Hydrogen	207-215	regulator of calcineurin 2	Homo sapiens	81-85
25978109-10	2015	Western blot analysis revealed a marked decrease in apolipoprotein B100 and an increase in apolipoprotein M in plasma of the H2 group.	Hydrogen	125-127	apolipoprotein B	Homo sapiens	52-71
25978109-10	2015	Western blot analysis revealed a marked decrease in apolipoprotein B100 and an increase in apolipoprotein M in plasma of the H2 group.	Hydrogen	125-127	apolipoprotein M	Homo sapiens	91-107
26197935-11	2015	Intramuscular anabolic signaling analysis revealed a significantly greater (P = 0.03) phosphorylation of IGF-1 receptor at 1H following HV compared to HI.	Hydrogen	123-125	insulin like growth factor 1	Homo sapiens	105-110
25895142-5	2015	We found that hydrogen-rich medium could inhibit adhesion of monocytes to endothelial cells and decrease levels of adhesion molecules, whereas the levels of transepithelial/endothelial electrical resistance values and the expression of vascular endothelial cadherin were increased after hydrogen-rich medium treatment.	Hydrogen	14-22	cadherin 5	Homo sapiens	236-265
25895142-5	2015	We found that hydrogen-rich medium could inhibit adhesion of monocytes to endothelial cells and decrease levels of adhesion molecules, whereas the levels of transepithelial/endothelial electrical resistance values and the expression of vascular endothelial cadherin were increased after hydrogen-rich medium treatment.	Hydrogen	287-295	cadherin 5	Homo sapiens	236-265
25895145-0	2015	Hydrogen Gas Alleviates the Intestinal Injury Caused by Severe Sepsis in Mice by Increasing the Expression of Heme Oxygenase-1.	Hydrogen	0-8	heme oxygenase 1	Mus musculus	110-126
25895145-15	2015	Hydrogen has the capacity to protect mice from organ injury in severe sepsis through a mechanism involving HO-1.	Hydrogen	0-8	heme oxygenase 1	Mus musculus	107-111
26010498-2	2015	GRL-5010A and GRL-4410A were designed to introduce hydrogen bond interactions with the flexible flaps of the PR by incorporating gem-difluorines and alkoxy, respectively, at the C4 position of the bis-THF of darunavir.	Hydrogen	51-59	nuclear receptor subfamily 3 group C member 1	Homo sapiens	14-17
26024150-4	2015	Additionally, a newly assigned CH3   O C intermolecular hydrogen bond at 3008 cm(-1) in the PIPOZ system provides extra information on the interactions between C-H and C O groups.	Hydrogen	56-64	ryanodine receptor 1	Homo sapiens	160-171
26125821-0	2015	Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin.	Hydrogen	22-30	cadherin 5	Homo sapiens	152-181
25978680-0	2015	Probing the Conformational and Functional Consequences of Disulfide Bond Engineering in Growth Hormone by Hydrogen-Deuterium Exchange Mass Spectrometry Coupled to Electron Transfer Dissociation.	Hydrogen	106-114	growth hormone 1	Homo sapiens	88-102
26125821-8	2015	Liquid rich in hydrogen could reduce LPS-induced production of adhesion molecules and endothelium-hyaline leukocyte conglutination, and influence the expression and distribution of VE-cadherin to regulate the permeability of the endothelium.	Hydrogen	15-23	cadherin 5	Homo sapiens	181-192
25656343-3	2015	The intramolecular O-H   Cl hydrogen bond specific to syn-2-ClPhOH is key.	Hydrogen	28-36	synapsin II	Homo sapiens	54-59
25950663-2	2015	By selectively deuterating the substrate (ethanolamine) and/or the beta-carbon of the 5"-deoxyadenosyl moiety of the intrinsic coenzyme B12 , it was possible to experimentally probe both the forward and reverse hydrogen atom transfers between the 5"-deoxyadenosyl radical and substrate during single-turnover stopped-flow measurements.	Hydrogen	211-219	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	136-139
25219547-6	2015	Activation of PSGR1 evoked an increase in intracellular pH mediated by the sodium/hydrogen exchanger NHE1.	Hydrogen	82-90	solute carrier family 9 member A1	Homo sapiens	101-105
25847248-8	2015	The extensive p180C-p70 interactions involve 20 hydrogen bonds and a number of hydrophobic interactions resulting in an extended buried surface of 4080 A(2).	Hydrogen	48-56	ubiquitin associated and SH3 domain containing B	Homo sapiens	20-23
26047940-10	2015	CONCLUSION: Hydrogen can attenuate severe burn-induced early AKI; the mechanisms of protection include the inhibition of oxidative stress induced apoptosis and inflammation, which may be mediated by regulation of the MAPKs, Akt and NF-kappaB signalling pathways.	Hydrogen	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	224-227
25851798-2	2015	No studies have reported long-term outcomes relating to both high-sensitivity cardiac troponin T (hs-cTnT) and high-sensitivity cardiac troponin I (hs-cTnI) in these patients.	Hydrogen	98-100	troponin T2, cardiac type	Homo sapiens	101-105
25982331-1	2015	Combination of the Suzuki cross-coupling and nucleophilic aromatic substitution of hydrogen (SN(H)) reactions proved to be a convenient method for the synthesis of C(4) and/or C(5) mono(thienyl) and di(thienyl) substituted pyrimidines from commercially available 5-bromopyrimidine.	Hydrogen	83-91	hemolytic complement	Mus musculus	176-180
25961423-7	2015	Indeed, substitution of amino acids with few probabilities of rotamer changes in PDGFRbeta (M133A, N163E and N179S) and energy stability due to the formation of hydrogen bond in PDGFRbeta could explain the specificity of PDGFRbeta.	Hydrogen	161-169	platelet derived growth factor receptor beta	Homo sapiens	81-90
25631232-8	2015	ATP-sensitive potassium (KATP ) channels, the molecular target that mediates part of the vascular functions of H2 S, were shown to be involved in the upstream activation of Akt and ERK1/2.	Hydrogen	111-113	AKT serine/threonine kinase 1	Homo sapiens	173-176
25631232-8	2015	ATP-sensitive potassium (KATP ) channels, the molecular target that mediates part of the vascular functions of H2 S, were shown to be involved in the upstream activation of Akt and ERK1/2.	Hydrogen	111-113	mitogen-activated protein kinase 3	Homo sapiens	181-187
25631232-9	2015	Moreover, the up-regulation of fibroblast growth factor-2 was dependent on CSE-derived H2 S response to H2 S and KATP activation.	Hydrogen	87-89	fibroblast growth factor 2	Homo sapiens	31-57
25907201-4	2015	Further mechanistic investigations demonstrate that the 1,7-hydrogen atom transfer is a free-radical process, whereby hydrogen migrates from C18 to C17, as evidenced by double-18- deuterium-labeled isotope experiments.	Hydrogen	60-68	Bardet-Biedl syndrome 9	Homo sapiens	141-144
25907201-4	2015	Further mechanistic investigations demonstrate that the 1,7-hydrogen atom transfer is a free-radical process, whereby hydrogen migrates from C18 to C17, as evidenced by double-18- deuterium-labeled isotope experiments.	Hydrogen	118-126	Bardet-Biedl syndrome 9	Homo sapiens	141-144
26136944-10	2015	Inhalation of hydrogen gas at 2% concentration for 1 h significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, the expression of cytokines, including IL-6, TNF-alpha, early growth response protein 1 (Egr-1) and IL-1beta, and morphological damage.	Hydrogen	14-22	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	122-148
26136944-10	2015	Inhalation of hydrogen gas at 2% concentration for 1 h significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, the expression of cytokines, including IL-6, TNF-alpha, early growth response protein 1 (Egr-1) and IL-1beta, and morphological damage.	Hydrogen	14-22	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	150-153
26136944-10	2015	Inhalation of hydrogen gas at 2% concentration for 1 h significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, the expression of cytokines, including IL-6, TNF-alpha, early growth response protein 1 (Egr-1) and IL-1beta, and morphological damage.	Hydrogen	14-22	interleukin 6	Rattus norvegicus	206-210
26136944-10	2015	Inhalation of hydrogen gas at 2% concentration for 1 h significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, the expression of cytokines, including IL-6, TNF-alpha, early growth response protein 1 (Egr-1) and IL-1beta, and morphological damage.	Hydrogen	14-22	tumor necrosis factor	Rattus norvegicus	212-221
26136944-10	2015	Inhalation of hydrogen gas at 2% concentration for 1 h significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, the expression of cytokines, including IL-6, TNF-alpha, early growth response protein 1 (Egr-1) and IL-1beta, and morphological damage.	Hydrogen	14-22	early growth response 1	Rattus norvegicus	223-254
26136944-10	2015	Inhalation of hydrogen gas at 2% concentration for 1 h significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, the expression of cytokines, including IL-6, TNF-alpha, early growth response protein 1 (Egr-1) and IL-1beta, and morphological damage.	Hydrogen	14-22	early growth response 1	Rattus norvegicus	256-261
26136944-10	2015	Inhalation of hydrogen gas at 2% concentration for 1 h significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, the expression of cytokines, including IL-6, TNF-alpha, early growth response protein 1 (Egr-1) and IL-1beta, and morphological damage.	Hydrogen	14-22	interleukin 1 beta	Rattus norvegicus	267-275
25961423-7	2015	Indeed, substitution of amino acids with few probabilities of rotamer changes in PDGFRbeta (M133A, N163E and N179S) and energy stability due to the formation of hydrogen bond in PDGFRbeta could explain the specificity of PDGFRbeta.	Hydrogen	161-169	platelet derived growth factor receptor beta	Homo sapiens	178-187
26601374-15	2015	These results suggested that L has strong binding affinity towards NO3- with high selectivity, which may be ascribed to the specific hydrogen bonding between the L and active H atom of the bipyrydinium salts.	Hydrogen	133-141	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
25961423-7	2015	Indeed, substitution of amino acids with few probabilities of rotamer changes in PDGFRbeta (M133A, N163E and N179S) and energy stability due to the formation of hydrogen bond in PDGFRbeta could explain the specificity of PDGFRbeta.	Hydrogen	161-169	platelet derived growth factor receptor beta	Homo sapiens	178-187
25818978-0	2015	Hydrogen gas inhibits high-mobility group box 1 release in septic mice by upregulation of heme oxygenase 1.	Hydrogen	0-8	heme oxygenase 1	Mus musculus	90-106
26120483-9	2015	RESULTS: Lawsone and THN can be considered to efficiently bind with NOS, CAT, GSH, GR, G6PDH and NADPH, which has been confirmed through hydrogen bond affinity with the respective amino acids.	Hydrogen	137-145	catalase	Homo sapiens	73-76
25533677-8	2015	RESULTS: Compared with those in isoproterenol-MI group, hydrogen-rich saline decreased malondialdehyde and 8-hydroxy-desoxyguanosine concentrations, enhanced superoxide dismutase and Na(+)-K(+)-ATPase activity, lowered Ca(2+)-ATPase activity and decreased interleukin-6 and tumour necrosis factor-alpha levels in the serum and/or cardiac tissue of rats.	Hydrogen	56-64	interleukin 6	Rattus norvegicus	256-302
25818978-9	2015	However, therapy with H2 increased the survival rate and alleviated the severity of lung injury, reduced the HMGB1 level, and increased the HO-1 and Nrf2 levels in septic mice.	Hydrogen	22-24	heme oxygenase 1	Mus musculus	140-144
25818978-9	2015	However, therapy with H2 increased the survival rate and alleviated the severity of lung injury, reduced the HMGB1 level, and increased the HO-1 and Nrf2 levels in septic mice.	Hydrogen	22-24	nuclear factor, erythroid derived 2, like 2	Mus musculus	149-153
25818978-3	2015	In this study, we hypothesized that the protective function of H2 in mice with septic lung injury occurred through the activation of heme oxygenase 1 (HO-1) and its upstream regulator nuclear factor-erythroid 2 p45-related factor 2 (Nrf2).	Hydrogen	63-65	heme oxygenase 1	Mus musculus	133-149
25818978-10	2015	Moreover, the HO-1 inhibitor zinc protoporphyrin IX significantly eliminated the protective effect of H2 on septic lung injury.	Hydrogen	102-104	heme oxygenase 1	Mus musculus	14-18
25818978-11	2015	CONCLUSIONS: H2 plays a significant role in regulating the release of the inflammatory cytokine HMGB1 in septic mice, which is partially mediated through the activation of HO-1 as a downstream molecule of Nrf2.	Hydrogen	13-15	heme oxygenase 1	Mus musculus	172-176
25818978-11	2015	CONCLUSIONS: H2 plays a significant role in regulating the release of the inflammatory cytokine HMGB1 in septic mice, which is partially mediated through the activation of HO-1 as a downstream molecule of Nrf2.	Hydrogen	13-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	205-209
25818978-3	2015	In this study, we hypothesized that the protective function of H2 in mice with septic lung injury occurred through the activation of heme oxygenase 1 (HO-1) and its upstream regulator nuclear factor-erythroid 2 p45-related factor 2 (Nrf2).	Hydrogen	63-65	heme oxygenase 1	Mus musculus	151-155
25818978-3	2015	In this study, we hypothesized that the protective function of H2 in mice with septic lung injury occurred through the activation of heme oxygenase 1 (HO-1) and its upstream regulator nuclear factor-erythroid 2 p45-related factor 2 (Nrf2).	Hydrogen	63-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	233-237
25996822-1	2015	We have previously shown that incubation for 1h with excess glucose or leucine causes insulin resistance in rat extensor digitorum longus (EDL) muscle by inhibiting AMP-activated protein kinase (AMPK).	Hydrogen	45-47	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	165-193
25924972-1	2015	An electrocatalytic material for the H2 evolution reaction (HER) in acidic aqueous solution has been prepared by electropolymerization of Co(ii) dibenzotetraaza[14] annulene (CoTAA).	Hydrogen	37-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-144
25858688-1	2015	A molecular photocatalyst consisting of a Ru(II) photocenter, a tetrapyridophenazine bridging ligand, and a PtX2 (X=Cl or I) moiety as the catalytic center functions as a stable system for light-driven hydrogen production.	Hydrogen	202-210	paired like homeodomain 2	Homo sapiens	108-112
25996822-1	2015	We have previously shown that incubation for 1h with excess glucose or leucine causes insulin resistance in rat extensor digitorum longus (EDL) muscle by inhibiting AMP-activated protein kinase (AMPK).	Hydrogen	45-47	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	195-199
25996822-5	2015	The subsequent decreases at 1h were accompanied by phosphorylation of alphaAMPK at Ser485/491, and at 2h by decreased SIRT1 expression and increased PP2A activity, all of which have previously been shown to diminish AMPK activity.	Hydrogen	28-30	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	75-79
26191363-4	2015	Meanwhile, substitution of the pyrimidine NH with an oxygen atom reversed the PLK1/BRD4 selectivity to convert BI-2536 into a BRD4-selective inhibitor, likely owing to the loss of a critical hydrogen bond in PLK1.	Hydrogen	191-199	bromodomain containing 4	Homo sapiens	83-87
25603016-3	2015	Catalase is a potent antioxidant enzyme that coverts hydrogen peroxide into hydrogen and water.	Hydrogen	53-61	catalase	Homo sapiens	0-8
26221308-8	2015	We found hydrogen-rich solutions treatment groups showed the decreased MDA, MPO, IL-6 and TNF-alpha levels, and increased SOD, IL-10 comparing with those of non-hydrogen solutions administration groups.	Hydrogen	9-17	myeloperoxidase	Homo sapiens	76-79
26178498-0	2015	[Effects of hydrogen-rich saline on Akt/GSK3beta signaling pathways and cardiac function during myocardial ischemia-reperfusion in rats].	Hydrogen	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	36-39
26178498-1	2015	OBJECTIVE: To explore the effects of hydrogen-rich saline on Akt/GSK3beta signaling pathways and cardiac function during myocardial ischemia-reperfusion (I/R) in rats.	Hydrogen	37-45	AKT serine/threonine kinase 1	Rattus norvegicus	61-64
26221308-8	2015	We found hydrogen-rich solutions treatment groups showed the decreased MDA, MPO, IL-6 and TNF-alpha levels, and increased SOD, IL-10 comparing with those of non-hydrogen solutions administration groups.	Hydrogen	9-17	interleukin 6	Homo sapiens	81-85
26221308-8	2015	We found hydrogen-rich solutions treatment groups showed the decreased MDA, MPO, IL-6 and TNF-alpha levels, and increased SOD, IL-10 comparing with those of non-hydrogen solutions administration groups.	Hydrogen	9-17	tumor necrosis factor	Homo sapiens	90-99
26221308-8	2015	We found hydrogen-rich solutions treatment groups showed the decreased MDA, MPO, IL-6 and TNF-alpha levels, and increased SOD, IL-10 comparing with those of non-hydrogen solutions administration groups.	Hydrogen	9-17	superoxide dismutase 1	Homo sapiens	122-125
25707580-8	2015	Ingenuity Pathway Analysis revealed that H2 suppressed the expression of nuclear factor-kappa B (NF-kappaB)-regulated genes.	Hydrogen	41-43	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-95
25856545-6	2015	The simulation studies indicated different possible mechanisms and revealed the important influence of hydrophobic interactions and hydrogen bonds in the flexible cavity of P-gp.	Hydrogen	132-140	ATP binding cassette subfamily B member 1	Homo sapiens	173-177
25816984-3	2015	We found that the hydrogen bond and van der Waals force are the major binding forces in the binding of oridonin to HSA.	Hydrogen	18-26	albumin	Homo sapiens	115-118
24961937-4	2015	Additionally, acute effects of N-acetylcysteine and hydrogen-rich saline on vascular endothelial growth factor (VEGF)-induced tubule formation and migration of human umbilical vein endothelial cells (HUVEC) were also evaluated.	Hydrogen	52-60	vascular endothelial growth factor A	Homo sapiens	76-110
24961937-4	2015	Additionally, acute effects of N-acetylcysteine and hydrogen-rich saline on vascular endothelial growth factor (VEGF)-induced tubule formation and migration of human umbilical vein endothelial cells (HUVEC) were also evaluated.	Hydrogen	52-60	vascular endothelial growth factor A	Homo sapiens	112-116
25736793-1	2015	PURPOSE: As part of a large scale systematic screen to determine the effects of gene knockout mutations in mice, a retinal phenotype was found in mice lacking the Slc9a8 gene, encoding the sodium/hydrogen ion exchange protein NHE8.	Hydrogen	196-204	solute carrier family 9 (sodium/hydrogen exchanger), member 8	Mus musculus	163-169
25736793-1	2015	PURPOSE: As part of a large scale systematic screen to determine the effects of gene knockout mutations in mice, a retinal phenotype was found in mice lacking the Slc9a8 gene, encoding the sodium/hydrogen ion exchange protein NHE8.	Hydrogen	196-204	solute carrier family 9 (sodium/hydrogen exchanger), member 8	Mus musculus	226-230
25871523-0	2015	Different conformational dynamics of various active states of beta-arrestin1 analyzed by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	89-97	arrestin beta 1	Homo sapiens	62-76
25871523-6	2015	Here, we analyzed the conformational dynamics of beta-arrestin1 with various mutants (R169E, p44, 3A, and Delta7) by hydrogen/deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	117-125	arrestin beta 1	Homo sapiens	49-63
25946161-9	2015	Furthermore, molecular docking analysis revealed that either an 11-OH or a 16-OAc group spatially close to a five-membered lactone ring significantly facilitated the anchoring of these compounds within site I of the HSA pocket via hydrogen bonding (H-bonding) with Tyr150 or Lys199, respectively.	Hydrogen	231-239	albumin	Homo sapiens	216-219
29403633-3	2015	The potential susceptibility of Ni-S bonds in molecular hydrogen evolution catalysts to degradation via C-S bond cleavage is discussed.	Hydrogen	56-64	solute carrier family 5 member 5	Homo sapiens	32-36
25612933-2	2015	The results indicated that the nature of forces involved in binding interaction between HSA and FU molecule were mainly van der Waal"s forces and hydrogen bonding interactions.	Hydrogen	146-154	albumin	Homo sapiens	88-91
25707580-8	2015	Ingenuity Pathway Analysis revealed that H2 suppressed the expression of nuclear factor-kappa B (NF-kappaB)-regulated genes.	Hydrogen	41-43	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-106
25707580-9	2015	Western blot analysis showed that H2 attenuated ERK, p38 MAPK, and NF-kappaB signaling in mouse livers.	Hydrogen	34-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	67-76
25933766-0	2015	Quantum mechanical differential and integral cross sections for the C((1)D) + H2(nu = 0, j = 0)   CH(nu", j") + H reaction.	Hydrogen	78-80	C1D nuclear receptor corepressor	Homo sapiens	68-74
26653223-10	2015	Hydrogen-saline may increase expression of HO-1 and alleviate oxidative stress damage in lung.	Hydrogen	0-8	heme oxygenase 1	Mus musculus	43-47
26653223-8	2015	HO-1 expression trend and distribution in PQ+hydrogen saline group are similar with PQ group, but were significantly higher than that of PQ group and the control group each time point (P &lt; 0.05).	Hydrogen	45-53	heme oxygenase 1	Mus musculus	0-4
25933766-1	2015	Accurate quantum dynamics calculations for the C((1)D) + H2 reaction are performed using a real wave packet approach with full Coriolis coupling.	Hydrogen	57-59	C1D nuclear receptor corepressor	Homo sapiens	47-53
25578810-6	2015	The molecular dynamics simulation has been used to study the hydrogen bond interactions between the dimer interface residues of the monomers in native and mutated forms of SOD1 in apo- and holo-states.	Hydrogen	61-69	superoxide dismutase 1	Homo sapiens	172-176
25880481-3	2015	Solanezumab accommodates a large Abeta epitope (960 A(2) buried interface over residues 16 to 26) that forms extensive contacts and hydrogen bonds to the antibody, largely via main-chain Abeta atoms and a deeply buried Phe19-Phe20 dipeptide core.	Hydrogen	132-140	amyloid beta precursor protein	Homo sapiens	33-38
25880481-4	2015	The conformation of Abeta captured is an intermediate between observed sheet and helical forms with intramolecular hydrogen bonds stabilising residues 20-26 in a helical conformation.	Hydrogen	115-123	amyloid beta precursor protein	Homo sapiens	20-25
25644628-1	2015	Microbial fuel cells (MFCs) and microbial electrolysis cells (MECs) are two types of microbial bioelectrochemical systems (BESs) that use microorganisms to convert chemical energy in wastewaters into useful energy products such as (bio)electricity (MFC) or hydrogen gas (MEC).	Hydrogen	257-265	C-C motif chemokine ligand 28	Homo sapiens	62-65
26574378-0	2015	1H Chemical Shifts in Paramagnetic Co(II) Pyrazolylborate Complexes: A First-Principles Study.	Hydrogen	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-41
25588773-11	2015	Bundled SPC leads to an increased hydration of the active site region, more hydrogen bonds between water and catalytic triad residues, and a significantly slower exchange of water molecules between the active site and the bulk.	Hydrogen	76-84	proline rich protein gene cluster	Homo sapiens	8-11
25892966-0	2015	1H NMR based serum metabolic profiles associated with pathological progression of pancreatic islet beta cell tumor in Rip1-Tag2 mice.	Hydrogen	0-2	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	118-122
25525953-1	2015	In the past 2 decades, molecular hydrogen emerged as a novel therapeutic agent, with antioxidant, anti-inflammatory and anti-apoptotic effects demonstrated in plethora of animal disease models and human studies.	Hydrogen	33-41	EH domain containing 2	Homo sapiens	7-13
25909811-5	2015	The simulations unveiled that binding of HIV-1 Tat to CDK9 not only stabilized hydrogen bonds (H-bonds) between ATP and hinge residues Asp104 and Cys106, as well as between ATP and invariant Lys48, but also facilitated the salt bridge network pertaining to the phosphorylated Thr186 at the activation loop.	Hydrogen	79-87	cyclin dependent kinase 9	Homo sapiens	54-58
25765013-0	2015	Competition between nucleophilic substitution of halogen (SN Ar) versus substitution of hydrogen (SN ArH)-a mass spectrometry and computational study.	Hydrogen	88-96	low density lipoprotein receptor adaptor protein 1	Homo sapiens	101-104
25608846-3	2015	The catalytic performance of iNOS is proposed to rely mainly on the haem midpoint potential and the ability of the substrate L-Arg to provide a hydrogen bond for oxygen activation (O-O scission).	Hydrogen	144-152	nitric oxide synthase 2	Homo sapiens	29-33
25578810-7	2015	The results obtained by this analysis reveal the fact that the loss of hydrogen bond interactions between the monomers of the dimer is responsible for the reduced stability of the apo- and holo-mutant forms of SOD1.	Hydrogen	71-79	superoxide dismutase 1	Homo sapiens	210-214
25662515-8	2015	The conversion of inactive to active Src is accompanied by electrostatic exchanges involving the breaking and making of distinct sets of kinase domain salt bridges and hydrogen bonds.	Hydrogen	168-176	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-40
25664688-5	2015	Hydrogen-deuterium exchange mass spectrometry (HDX-MS) was used to identify a conformational epitope comprised of discontinuous strands that fold to form a beta sheet in the native structure.	Hydrogen	0-8	amyloid beta precursor protein	Homo sapiens	154-160
25467059-5	2015	In silico study revealed a strong affinity of the derivative R20:4 to the transmembrane region of SERCA1, stabilized via hydrogen bonds with Glu90, Glu771, Thr778 and Thr848 residues.	Hydrogen	121-129	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	98-104
25742870-0	2015	1H- and 13C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer"s disease.	Hydrogen	0-2	thymus cell antigen 1, theta	Mus musculus	32-37
25625663-2	2015	In silico analysis of the mode of binding demonstrated that the 3-hydroxypropyloxy (3-HP) group of eldecalcitol offers additional hydrogen bond and CH-pi interaction for the binding to DBP and VDR.	Hydrogen	130-138	D-box binding PAR bZIP transcription factor	Homo sapiens	185-188
25656046-0	2015	Towards hydrogen evolution initiated by LED light: 2-(1H-1,2,3-Triazol-4-yl)pyridine-containing polymers as photocatalyst.	Hydrogen	8-16	small integral membrane protein 10 like 2A	Homo sapiens	40-43
25644785-8	2015	Diclofenac and Curcumin inhibited the Bcl-2 protein by directly interacting at the active site by multiple hydrogen bonding, as also evident by negative glide score of Bcl-2.	Hydrogen	107-115	BCL2, apoptosis regulator	Rattus norvegicus	38-43
25662515-13	2015	Both ATP and targeted therapeutic Src protein kinase inhibitors such as dasatinib and ponatinib make hydrophobic contacts with catalytic spine residues and form hydrogen bonds with hinge residues connecting the small and large kinase lobes.	Hydrogen	161-169	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	34-37
25611554-0	2015	Rhodathiaborane reaction cycles driven by C2H4 and H2: synthesis and characterization of [(H)2(PPh3)RhSB8H7(PPh3)] and [(eta(2)-C2H4)(PPh3)RhSB8H7(PPh3)].	Hydrogen	51-53	caveolin 1	Homo sapiens	95-99
25658971-2	2015	This study presents density functional theory calculations of the CYP-mediated metabolism of acetaminophen and a series of related compounds that can form reactive metabolites by hydrogen abstraction.	Hydrogen	179-187	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	66-69
25775573-8	2015	Kinetic studies were carried out in fused water droplets for acid-induced unfolding of cytochrome c and hydrogen-deuterium exchange in bradykinin.	Hydrogen	104-112	kininogen 1	Homo sapiens	135-145
25611554-0	2015	Rhodathiaborane reaction cycles driven by C2H4 and H2: synthesis and characterization of [(H)2(PPh3)RhSB8H7(PPh3)] and [(eta(2)-C2H4)(PPh3)RhSB8H7(PPh3)].	Hydrogen	51-53	caveolin 1	Homo sapiens	108-112
25611554-0	2015	Rhodathiaborane reaction cycles driven by C2H4 and H2: synthesis and characterization of [(H)2(PPh3)RhSB8H7(PPh3)] and [(eta(2)-C2H4)(PPh3)RhSB8H7(PPh3)].	Hydrogen	51-53	caveolin 1	Homo sapiens	108-112
25611554-0	2015	Rhodathiaborane reaction cycles driven by C2H4 and H2: synthesis and characterization of [(H)2(PPh3)RhSB8H7(PPh3)] and [(eta(2)-C2H4)(PPh3)RhSB8H7(PPh3)].	Hydrogen	51-53	caveolin 1	Homo sapiens	108-112
25581460-7	2015	This illustrates the crucial yet complex role of electrostatic and hydrogen bonding interactions in modulating the anchoring and insertion of Abeta peptides into lipid bilayers.	Hydrogen	67-75	amyloid beta precursor protein	Homo sapiens	142-147
25781978-7	2015	We also found the critical importance of the hydrogen bond network involving H1, H1" and H2 helices of CycT1.	Hydrogen	45-53	cyclin T1	Homo sapiens	103-108
24954438-5	2015	In the molecular modeling study, compound 12b was bound into the active pocket of EGFR with two hydrogen bond and with minimum binding free energy  Gb = -25.1125 kcal/mol.	Hydrogen	96-104	epidermal growth factor receptor	Homo sapiens	82-86
25635520-3	2015	Neighboring molecules in L1H and 1 are linked into supramolecular chains through hydrogen bonds.	Hydrogen	81-89	L1 cell adhesion molecule	Homo sapiens	25-34
33429518-5	2015	For pro-inflammatory macrophages, polarity and the ability to hydrogen bond appear to significantly impact TNF-alpha secretion while charge impacted pro-angiogenic macrophages.	Hydrogen	62-70	tumor necrosis factor	Homo sapiens	107-116
25702700-1	2015	The initial [2 + 2]-cycloadduct between a chromium aminocarbene and a tethered alkene undergoes a beta-hydrogen elimination very efficiently when triphenylphosphine is added as a ligand.	Hydrogen	103-111	amyloid beta precursor protein	Homo sapiens	96-102
25684204-5	2015	Hydrogen-deuterium exchange mass spectrometry demonstrated that the N-terminal conformational changes in BAX induced by a triggering BIM BH3 helix were suppressed by the BCL-2 BH4 helix.	Hydrogen	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	105-108
25684204-5	2015	Hydrogen-deuterium exchange mass spectrometry demonstrated that the N-terminal conformational changes in BAX induced by a triggering BIM BH3 helix were suppressed by the BCL-2 BH4 helix.	Hydrogen	0-8	BCL2 apoptosis regulator	Homo sapiens	170-175
25729848-5	2015	Agonists were characterized by their linear binding geometry and the fact that they bound deeply in the hTAS2R39 pocket, mapping the hydrogen donor feature based on T5.45 and N3.36, analogues of which have been proposed to play a key role in activation of GPCRs.	Hydrogen	133-141	taste 2 receptor member 39	Homo sapiens	104-112
26045773-5	2015	According to levels of urine calcium excretion, renal calcium deposition, a serum excretion of kidney injury molecule-1 (KIM-1) assay and a TUNEL assay, inhalation of H2 could successfully decrease the CaOx crystallizations and protect against renal injury.	Hydrogen	167-169	hepatitis A virus cellular receptor 1	Mus musculus	95-119
26045773-5	2015	According to levels of urine calcium excretion, renal calcium deposition, a serum excretion of kidney injury molecule-1 (KIM-1) assay and a TUNEL assay, inhalation of H2 could successfully decrease the CaOx crystallizations and protect against renal injury.	Hydrogen	167-169	hepatitis A virus cellular receptor 1	Mus musculus	121-126
25305622-4	2015	Our results have shown that fulvic acid binds to Tf and form a new complex, and the calculated apparent association constants are 5.04x10(8) M(-1), 5.48x10(7) M(-1), 7.38x10(6) M(-1) from the fluorescence quenching at 288 K, 298 K, and 310 K. The thermodynamic parameters indicate that hydrogen bonding and weak van der Waals are involved in the interaction between fulvic acid and Tf.	Hydrogen	286-294	transferrin	Homo sapiens	49-51
25490569-8	2015	In addition, the hydrogen uptake of Pd/AC-ox3 with lower oxygen contents demonstrates that the hydrogen spillover enhancement gradually disappears when the pressure is increased to more than 2 MPa (i.e., a transition from spillover to physisorption).	Hydrogen	17-25	acyl-CoA oxidase 3, pristanoyl	Homo sapiens	39-45
25490569-8	2015	In addition, the hydrogen uptake of Pd/AC-ox3 with lower oxygen contents demonstrates that the hydrogen spillover enhancement gradually disappears when the pressure is increased to more than 2 MPa (i.e., a transition from spillover to physisorption).	Hydrogen	95-103	acyl-CoA oxidase 3, pristanoyl	Homo sapiens	39-45
25544389-8	2015	Intermolecular interactions occurred between the two azoles as well as CYP2E1 residue side chains and backbone and involved both hydrophobic contacts and hydrogen bonds.	Hydrogen	154-162	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	71-77
25632829-9	2015	Mie-type resonances centered at 9.8 mum for the Au-Pd supercrystals disappear once the Pd shells are converted into PdH after hydrogen absorption.	Hydrogen	126-134	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	116-119
25594114-12	2015	The DFT-optimized structure of the starting Fe(V)(O) and the transition state indicates that the rate enhancement is due to the transition state"s favored stabilization over the reactant due to enhanced hydrogen bonding with water.	Hydrogen	203-211	FEV transcription factor, ETS family member	Homo sapiens	44-49
25558480-3	2015	The length of the spacer molecules and the C-alkyl tail length of the PgC macrocycle are tuned to influence the hydrogen bonding pattern and thus the overall architecture of the resultant SOFs.	Hydrogen	112-120	progastricsin	Homo sapiens	70-73
25183402-11	2015	Structure-activity relationship analysis showed that CYP2B6 and CYP3A4 inducers are bulky lipophilic molecules with a higher number of heavy atoms and a lower number of hydrogen bond donors.	Hydrogen	169-177	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	64-70
25358869-4	2015	The results of the PCA, the 2D correlation spectroscopic analysis, and the AAMD calculations clearly reveal that the thermal denaturation mechanisms and the degrees of hydrogen bonding in the spherical and rod-shaped insulin nanoparticles are different.	Hydrogen	168-176	insulin	Homo sapiens	217-224
24825450-2	2015	In silico data indicate that 4-HNE interacts with kinase domain of Akt1 with the total docking score of 6.0577 and also forms H-bond to Glu234 residue similar to highly potent Akt1 inhibitor imidazopiperidine analog 8b, in which the protonated imidazole nitrogen involves in two hydrogen bonds between Glu234 and Asp292.	Hydrogen	279-287	AKT serine/threonine kinase 1	Homo sapiens	67-71
25533319-4	2015	Both the Co(III) 4 and Co(II) 5 show electrocatalytic H2 generation in weakly acidic media as well as in water.	Hydrogen	54-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
25441927-6	2015	Hydrogen generation kinetics followed a Langmuir-type isotherm with reaction rate constant and adsorption constant of 6.77x10(-6) mol min(-1) and 14.45 M(-1), respectively.	Hydrogen	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	134-140
25625417-7	2015	Structural examination revealed diverse nonbonded interactions such as hydrogen bonds, hydrophobic forces and van der Waals contacts across the complex interface of mTOR with myricetin, conferring both stability and specificity for the mTOR-inhibitor binding.	Hydrogen	71-79	mechanistic target of rapamycin kinase	Homo sapiens	165-169
25542150-0	2015	Different conformational dynamics of beta-arrestin1 and beta-arrestin2 analyzed by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	83-91	arrestin beta 1	Homo sapiens	37-51
25542150-0	2015	Different conformational dynamics of beta-arrestin1 and beta-arrestin2 analyzed by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	83-91	arrestin beta 2	Homo sapiens	56-70
25636061-4	2015	Collected data included patient demographics, acute and chronic diagnosis, hs-cTnT and creatinine levels and date of death.	Hydrogen	75-77	troponin T2, cardiac type	Homo sapiens	78-82
25542150-5	2015	Here, we compared the conformational dynamics of beta-arrestin1 and beta-arrestin2 by hydrogen/deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	86-94	arrestin beta 1	Homo sapiens	49-63
25542150-5	2015	Here, we compared the conformational dynamics of beta-arrestin1 and beta-arrestin2 by hydrogen/deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	86-94	arrestin beta 2	Homo sapiens	68-82
25489766-2	2015	Compound 1 exhibits a ladder-shaped chain with Sc2(pydc)2 units, which further construct a supramolecular characteristic with water molecules via hydrogen bond.	Hydrogen	146-154	trans-2,3-enoyl-CoA reductase	Homo sapiens	47-50
25439939-3	2015	The shift of the thermal data were due to profound effect on the hydrogen bonding as evidenced by ATR-FTIR spectra since the OH stretching and scissoring bands decreased of about 15-26 cm(-1).	Hydrogen	65-73	ATR serine/threonine kinase	Homo sapiens	98-101
25559259-3	2015	H2 approaches 1 to afford an intermediate [Dmp(Dep)(HO)Ge(mu-S)Ru(PPh3)](+)-(H2) (2).	Hydrogen	0-2	caveolin 1	Homo sapiens	66-70
25477513-3	2015	Structural analysis demonstrates that YKL-39 interacts with chitooligosaccharides through hydrogen bonds and hydrophobic interactions.	Hydrogen	90-98	chitinase 3 like 2	Homo sapiens	38-44
25559259-5	2015	Then, the H2 further approaches the Ru center through a transition state TS2-3 to afford a dihydrogen sigma-complex [Dmp(Dep)(HO)Ge(mu-S)Ru(eta(2)-H2)(PPh3)](+) (3).	Hydrogen	10-12	caveolin 1	Homo sapiens	151-155
25448570-5	2015	A common feature pharmacophore for NTCP substrate uptake was developed, using 14 native bile acids and bile acid conjugates, yielding a model which featured three hydrophobes, one hydrogen bond donor, one negative ionizable feature and three excluded volumes.	Hydrogen	180-188	solute carrier family 10 member 1	Homo sapiens	35-39
25489786-4	2015	Using simulations without a ligand at 310 K, we first demonstrated that FABP3 adopts a wide-open conformation, achieved by a combination of two modes of dynamics: portal opening by a domain motion of the alpha-helices and gap opening by cleavage of the hydrogen-bond network between betaD and betaE strands.	Hydrogen	253-261	fatty acid binding protein 3	Homo sapiens	72-77
25494642-2	2015	The PDI-Co complex combines the photoactivity of the perylene dye with the electrocatalytic activity of the "Co(II)" center for photoelectrochemical hydrogen evolution reaction (HER).	Hydrogen	149-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
25494642-4	2015	The composite shows good performance in multiple cycle testing and the turnover number (TON vs Co(II)) of this hybrid material for hydrogen evolution reaction (754 after 5 h) is considerably higher than previously reported dye-sensitized cobalt-based catalysts.	Hydrogen	131-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
25407433-2	2015	All four amines form CAc-H   N hydrogen-bonded complexes.	Hydrogen	31-39	eukaryotic translation initiation factor 2B subunit epsilon	Homo sapiens	21-26
25407433-4	2015	The Lp   pi interacting structure of the 2,6-difluorophenylacetylene-trimethylamine complex is about 1.5 kJ mol(-1) higher in energy than the CAc-H   N hydrogen-bonded structure, which is the global minimum.	Hydrogen	152-160	eukaryotic translation initiation factor 2B subunit epsilon	Homo sapiens	142-147
25407433-6	2015	Interestingly the CAc-H   N hydrogen-bonded complex of 2,6-difluorophenylacetylene-triethylamine showed a smaller shift in the acetylenic C-H stretching frequency than the 2,6-difluorophenylacetylene-trimethylamine complex.	Hydrogen	28-36	eukaryotic translation initiation factor 2B subunit epsilon	Homo sapiens	18-23
25382675-0	2015	Towards high-level theoretical studies of large biodiesel molecules: an ONIOM [QCISD(T)/CBS:DFT] study of hydrogen abstraction reactions of C(n)H(2n+1)COOC(m)H(2m+1) + H. Recent interest in biodiesel combustion urges the need for the theoretical chemical kinetics of large alkyl ester molecules.	Hydrogen	106-114	cystathionine beta-synthase	Homo sapiens	88-91
25841189-2	2015	An improved hydrogen production rate was obtained in the FO-MEC (12.5+-1.84x10(-3)m(3)H2/m(3)/d) compared to that of the cation exchange membrane (CEM) - MEC (4.42+-0.04x10(-3)m(3)H2/m(3)/d) during batch tests (72h).	Hydrogen	12-20	C-C motif chemokine ligand 28	Homo sapiens	60-63
25382675-2	2015	The hydrogen abstraction reactions of alky esters CnH2n+1COOCmH2m+1 (n = 1-5, 9, 15; m = 1, 2) by a hydrogen radical were investigated by a computational technique based on a two-layer ONIOM method, employing a QCISD(T)/CBS method for the high layer and a DFT method for the low layer.	Hydrogen	4-12	cystathionine beta-synthase	Homo sapiens	220-223
25175686-4	2015	We have designed and synthesized a series of 6-methoxy-7-(3-morpholinopropoxy)-1-(2- phenoxyethyl)-quinoxalin-2(1H)-one derivatives as novel EGFR inhibitors.	Hydrogen	112-114	epidermal growth factor receptor	Homo sapiens	141-145
25841189-2	2015	An improved hydrogen production rate was obtained in the FO-MEC (12.5+-1.84x10(-3)m(3)H2/m(3)/d) compared to that of the cation exchange membrane (CEM) - MEC (4.42+-0.04x10(-3)m(3)H2/m(3)/d) during batch tests (72h).	Hydrogen	12-20	C-C motif chemokine ligand 28	Homo sapiens	154-157
25841189-2	2015	An improved hydrogen production rate was obtained in the FO-MEC (12.5+-1.84x10(-3)m(3)H2/m(3)/d) compared to that of the cation exchange membrane (CEM) - MEC (4.42+-0.04x10(-3)m(3)H2/m(3)/d) during batch tests (72h).	Hydrogen	86-88	C-C motif chemokine ligand 28	Homo sapiens	60-63
25841189-2	2015	An improved hydrogen production rate was obtained in the FO-MEC (12.5+-1.84x10(-3)m(3)H2/m(3)/d) compared to that of the cation exchange membrane (CEM) - MEC (4.42+-0.04x10(-3)m(3)H2/m(3)/d) during batch tests (72h).	Hydrogen	180-182	C-C motif chemokine ligand 28	Homo sapiens	60-63
25841189-3	2015	After an internal resistance analysis, it was confirmed that the enhanced hydrogen production in FO-MEC was attributed to the smaller charge transfer resistance than in the CEM-MEC (90.3Omega and 133.4Omega respectively).	Hydrogen	74-82	C-C motif chemokine ligand 28	Homo sapiens	100-103
25841189-3	2015	After an internal resistance analysis, it was confirmed that the enhanced hydrogen production in FO-MEC was attributed to the smaller charge transfer resistance than in the CEM-MEC (90.3Omega and 133.4Omega respectively).	Hydrogen	74-82	C-C motif chemokine ligand 28	Homo sapiens	177-180
25997722-9	2015	The levels of p-Akt (Ser 473) and Bcl-2 were significantly increased while Bax and cleaved caspase-3 were decreased by hydrogen treatment on the model of H/R.	Hydrogen	119-127	thymoma viral proto-oncogene 1	Mus musculus	16-19
25431146-5	2015	The representative compound 1h showed high, dose-dependent inhibition of MEK and ERK kinases.	Hydrogen	28-30	mitogen-activated protein kinase kinase 7	Homo sapiens	73-76
26584298-7	2015	Molecular docking revealed that compounds 6 and 7 interacted differently on AChE and BChE, by means of hydrophobic interactions and hydrogen bonding.	Hydrogen	132-140	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-80
25884113-6	2015	Additionally, high molecular flexibility and high number of hydrogen bond donors were also shown to be important that is in correspondence to previously reported pharmacophore model of 17beta-HSD1 inhibitors.	Hydrogen	60-68	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	185-196
25884113-7	2015	Furthermore, molecular docking of inhibitors to 17beta-HSD1 followed by anchor analysis suggested that three different pockets comprising of hydrogen bonding sites 1 and 2 as well as van der Waals contacts contributed to protein-ligand interactions.	Hydrogen	141-149	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	48-59
26098630-7	2015	Moreover, RMSD, RMSF, hydrogen bonds, salt bridge, and secondary structure analyses revealed that the NBD protein had a strong bond with p53 motif and the protein-ligand complex was stable.	Hydrogen	22-30	tumor protein p53	Homo sapiens	137-140
25273340-7	2015	It showed that TMAP reduced the number of intermolecular hydrogen bonds and increased the solvent accessible surface area in the oligonucleotide.	Hydrogen	57-65	cytoskeleton associated protein 2	Homo sapiens	15-19
25859918-12	2015	The amide hydrogen-deuterium exchange, monitored by nuclear magnetic resonance, highlights that lysozyme conformational flexibility is a condition for the formation of the protein-rich clusters and facilitates the nucleation of protein crystals.	Hydrogen	10-18	lysozyme	Homo sapiens	96-104
25377300-4	2015	In THP-1 cells, AMPKalpha1 was phosphorylated within 1h of menadione (15 muM)-triggered increases in [reactive oxygen species (ROS)]cyto, an effect which was followed by upregulation of PPARgamma and several of its target genes (PGC-1alpha, liver X receptor alpha [LXRalpha] and ATP-binding cassette subfamily A, member 1 [ABCA1]; 24-72 h), with these effects being blunted by co-administration of vitamin C (62.5 muM).	Hydrogen	53-55	peroxisome proliferator activated receptor gamma	Homo sapiens	186-195
25377300-4	2015	In THP-1 cells, AMPKalpha1 was phosphorylated within 1h of menadione (15 muM)-triggered increases in [reactive oxygen species (ROS)]cyto, an effect which was followed by upregulation of PPARgamma and several of its target genes (PGC-1alpha, liver X receptor alpha [LXRalpha] and ATP-binding cassette subfamily A, member 1 [ABCA1]; 24-72 h), with these effects being blunted by co-administration of vitamin C (62.5 muM).	Hydrogen	53-55	PPARG coactivator 1 alpha	Homo sapiens	229-239
25417766-7	2015	Furthermore, GlcN molecule was found to possess a good in silico binding mode into the CYP2E1 active site-forming bidentate hydrogen bonding with the Thr303 side chain.	Hydrogen	124-132	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	87-93
25878401-4	2015	Results showed that hydrogen-rich saline attenuated the following: (1) serum Cr and BUN, (2) pancreatic and renal pathological injuries, (3) renal MDA, (4) renal MPO, (5) serum IL-1beta, IL-6, and renal TNF-alpha, HMGB1, and (6) tyrosine nitration, IkappaB degradation, and NF-kappaB activation in renal tissues.	Hydrogen	20-28	interleukin 1 beta	Rattus norvegicus	177-185
26304834-1	2015	The sodium-hydrogen exchanger isoform-1 [NHE1] is a ubiquitously expressed plasma membrane protein that plays a central role in intracellular pH and cell volume homeostasis by catalyzing an electroneutral exchange of extracellular sodium and intracellular hydrogen.	Hydrogen	11-19	solute carrier family 9 member A1	Homo sapiens	41-45
25878401-4	2015	Results showed that hydrogen-rich saline attenuated the following: (1) serum Cr and BUN, (2) pancreatic and renal pathological injuries, (3) renal MDA, (4) renal MPO, (5) serum IL-1beta, IL-6, and renal TNF-alpha, HMGB1, and (6) tyrosine nitration, IkappaB degradation, and NF-kappaB activation in renal tissues.	Hydrogen	20-28	interleukin 6	Rattus norvegicus	187-191
25878401-4	2015	Results showed that hydrogen-rich saline attenuated the following: (1) serum Cr and BUN, (2) pancreatic and renal pathological injuries, (3) renal MDA, (4) renal MPO, (5) serum IL-1beta, IL-6, and renal TNF-alpha, HMGB1, and (6) tyrosine nitration, IkappaB degradation, and NF-kappaB activation in renal tissues.	Hydrogen	20-28	tumor necrosis factor	Rattus norvegicus	203-212
25372494-8	2015	A hydrogen bond between the polar hydrogen atoms at R1 and Cys86 can facilitate proper placement of the inhibitor in the binding pocket of Chk1 that favors binding.	Hydrogen	2-10	checkpoint kinase 1	Homo sapiens	139-143
25697520-0	2015	Probing conformational changes in rhodopsin using hydrogen-deuterium exchange coupled to mass spectrometry.	Hydrogen	50-58	rhodopsin	Homo sapiens	34-43
25697521-0	2015	Analysis of conformational changes in rhodopsin by histidine hydrogen-deuterium exchange.	Hydrogen	61-69	rhodopsin	Homo sapiens	38-47
25372494-8	2015	A hydrogen bond between the polar hydrogen atoms at R1 and Cys86 can facilitate proper placement of the inhibitor in the binding pocket of Chk1 that favors binding.	Hydrogen	34-42	checkpoint kinase 1	Homo sapiens	139-143
25092608-2	2014	The functions of the individual front loops of the eponymous TIM-barrel of triosephosphate isomerase are presented in a discussion of: (a) electrophilic catalysis, by amino acid side chains from loops 1 and 4, of abstraction of an alpha-carbonyl hydrogen from substrate dihydroxyacetone phosphate (DHAP) or d-glyceraldehyde 3-phosphate (DGAP).	Hydrogen	246-254	triosephosphate isomerase 1	Homo sapiens	61-64
25378534-0	2015	Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	99-107	Fc gamma receptor and transporter	Homo sapiens	42-62
25378534-3	2015	Here we studied the interaction between a full-length human IgG(1) and human FcRn via hydrogen/deuterium exchange mass spectrometry and targeted electron transfer dissociation to map sites perturbed by binding on both partners of the IgG-FcRn complex.	Hydrogen	86-94	Fc gamma receptor and transporter	Homo sapiens	77-81
25378534-10	2015	Our results provide new molecular insight into the IgG-FcRn interaction and illustrate the capability of hydrogen/deuterium exchange mass spectrometry to advance structural proteomics by providing detailed information on the conformation and dynamics of large protein complexes in solution.	Hydrogen	105-113	Fc gamma receptor and transporter	Homo sapiens	55-59
26337812-5	2015	Phyllanthin was found to effectively bind to serine (Ser) 280 at the active site of ALK5 by forming hydrogen bonds.	Hydrogen	100-108	transforming growth factor, beta receptor I	Mus musculus	84-88
25548518-10	2014	A molecular docking study showed that XKB bound to the active site of human cytochrome P450 3A4 and rat Cyp3a2 homology model via the formation of hydrogen bonds.	Hydrogen	147-155	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	76-95
25490095-8	2014	Changes in this hydrogen-bond network lead to the displacement of the c-Src-SH3 distal loop, resulting also in conformational changes of Leu100 that might be related to the binding of proline rich motifs.	Hydrogen	16-24	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	70-75
25404341-0	2014	Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange.	Hydrogen	99-107	transglutaminase 2	Homo sapiens	68-86
26123604-2	2015	The multi-spectroscopic data revealed that the complex easily formed between gamma-Fe2O3 nanoparticles and fibrinogen by mainly hydrogen bonding forces.	Hydrogen	128-136	fibrinogen beta chain	Homo sapiens	107-117
25467533-3	2015	Thus, the B ICF3 obey a set of rules which were originally proposed to rationalise the angular geometries of hydrogen-bonded complexes of the type B HX, but which were subsequently found to apply to their halogen-bonded analogues B XY, where XY is a dihalogen molecule, including ICl.	Hydrogen	109-117	cell division cycle associated 7	Homo sapiens	12-16
25319095-4	2014	Reaction of 1 or 2 with H2 yielded [PtH(mu-H)(FcPPB)] in which the borane is bound to a hydride ligand on platinum.	Hydrogen	24-26	familial progressive hyperpigmentation 1	Homo sapiens	40-44
25092608-2	2014	The functions of the individual front loops of the eponymous TIM-barrel of triosephosphate isomerase are presented in a discussion of: (a) electrophilic catalysis, by amino acid side chains from loops 1 and 4, of abstraction of an alpha-carbonyl hydrogen from substrate dihydroxyacetone phosphate (DHAP) or d-glyceraldehyde 3-phosphate (DGAP).	Hydrogen	246-254	triosephosphate isomerase 1	Homo sapiens	75-100
25971106-3	2014	An Oxygen-Hydrogen plasma treatment process is performed to remove OSP material.	Hydrogen	10-18	claudin 11	Homo sapiens	67-70
25283307-7	2014	Dynamic differences that contribute to the reduced drug susceptibility of the C-SA protease were investigated by performing hydrogen-deuterium exchange/mass spectrometry (HDX/MS) on unbound subtype B and C-SA proteases.	Hydrogen	124-132	heat shock protein family A (Hsp70) member 9	Homo sapiens	78-82
24125055-6	2014	According to trajectories, Z(HER2:342) specifically binds to HER2 through hydrogen bonds and salt bridges.	Hydrogen	74-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-33
24125055-6	2014	According to trajectories, Z(HER2:342) specifically binds to HER2 through hydrogen bonds and salt bridges.	Hydrogen	74-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	61-65
25443112-10	2014	Obesity and hs-cTnT provide independent and complementary prognostic information regarding the risk of incident HF.	Hydrogen	12-14	troponin T2, cardiac type	Homo sapiens	15-19
25463673-4	2014	MBI can spontaneously bind with CAT with one binding site through hydrogen bonds and van der Waals forces to form MBI-CAT complex.	Hydrogen	66-74	catalase	Homo sapiens	32-35
25463673-4	2014	MBI can spontaneously bind with CAT with one binding site through hydrogen bonds and van der Waals forces to form MBI-CAT complex.	Hydrogen	66-74	catalase	Homo sapiens	118-121
25091737-4	2014	Structural analyses of the AR-LBD-BUD31 complex revealed formation of an extra hydrogen bond between the Tyr+5 residue of the peptide and the AR.	Hydrogen	79-87	androgen receptor	Homo sapiens	27-29
25091737-4	2014	Structural analyses of the AR-LBD-BUD31 complex revealed formation of an extra hydrogen bond between the Tyr+5 residue of the peptide and the AR.	Hydrogen	79-87	androgen receptor	Homo sapiens	142-144
25144524-9	2014	The X-ray crystal structure of DAUDA-hIFABP revealed a FA-like binding mode where the carboxylate of DAUDA formed a network of hydrogen bonds with residues at the bottom of the binding cavity and the dansyl group interacted with residues in the portal region.	Hydrogen	127-135	fatty acid binding protein 2	Homo sapiens	37-43
25268658-3	2014	One-dimensional 1H NMR spectra confirm a progressive increase in flexibility of resonances in rhodopsin with increasing denaturant concentrations.	Hydrogen	16-18	rhodopsin	Homo sapiens	94-103
25268658-4	2014	Two-dimensional 1H-15N HSQC spectra of [15N]-alpha-lysine-labeled rhodopsin in which signals arise primarily from residues in the cytoplasmic (CP) domain and of [15N]-alpha,epsilon-tryptophan-labeled rhodopsin in which signals arise only from transmembrane (TM) and extracellular (EC) residues indicate qualitatively that EC and CP domains may be differentially affected by denaturation.	Hydrogen	16-18	rhodopsin	Homo sapiens	66-75
25421939-9	2014	The x-ray crystal structures of BI-D binding to WT and H171T IN CCD dimers coupled with binding free energy calculations revealed the importance of the Ndelta- protonated imidazole group of His171 for hydrogen bonding to the BI-D tert-butoxy ether oxygen and establishing electrostatic interactions with the inhibitor carboxylic acid, whereas these interactions were compromised upon substitution to Thr171.	Hydrogen	201-209	BH3 interacting domain death agonist	Homo sapiens	32-36
25251596-15	2014	In addition, 2% H2 inhalation promoted the expression and transposition of Nrf2 and the expression of HO-1 to mitigate brain injury in sepsis.	Hydrogen	16-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	75-79
25265274-0	2014	Hydrogen/deuterium exchange-protected oligomers populated during Abeta fibril formation correlate with neuronal cell death.	Hydrogen	0-8	amyloid beta precursor protein	Homo sapiens	65-70
25288792-5	2014	We have interrogated the protein-ligand interaction of STAT3 with these small molecule inhibitors by means of time-resolved electrospray ionization hydrogen-deuterium exchange mass spectrometry.	Hydrogen	148-156	signal transducer and activator of transcription 3	Homo sapiens	55-60
25417900-5	2014	Based on our experimental results and previous studies, a hypothesis of a hydrogen-assisted cracking (HAC) mechanism was proposed to explain the mechanism of TNTs" natural detachment and the control over of TNTs" stripping behaviors by post-treatment, in which the presence of protons at the interface between the TNT layer and the Ti substrate play an important role in controlling the two layers" cohesion.	Hydrogen	74-82	chromosome 16 open reading frame 82	Homo sapiens	158-161
25301772-7	2014	Docking experiments revealed that fluconazole and DTP binds in HSA mainly by hydrophobic interaction with the possibility of hydrogen bonds formation between the drugs and the residues Arg 222, Lys 199 and Lys 195 in HSA.	Hydrogen	125-133	albumin	Homo sapiens	63-66
25305687-1	2014	The interactions of gefitinib (Iressa) in EGFR are hydrogen bonding and van der Waals forces through quinazoline and aniline rings.	Hydrogen	51-59	epidermal growth factor receptor	Homo sapiens	42-46
25319141-1	2014	The rate constant of the H-abstraction reaction of formaldehyde (CH2O) by hydrogen atoms (H), CH2O + H = H2 + HCO, has been studied behind reflected shock waves with use of a sensitive mid-IR laser absorption diagnostic for CO, over temperatures of 1304-2006 K and at pressures near 1 atm.	Hydrogen	74-82	fibroblast growth factor receptor 1	Homo sapiens	94-113
25259383-2	2014	In the present contribution, we have addressed the issue of whether the collective hydrogen bond dynamics of water gets perturbed in the presence of GdmCl and its possible impact on the denaturation of a globular protein human serum albumin (HSA), using terahertz (THz) time domain spectroscopy (TTDS) in the frequency range of 0.3-2.0 THz.	Hydrogen	83-91	albumin	Homo sapiens	227-240
25424294-8	2014	The histochemical study showed lesser expression of COX-2 (p=0.0015) and Bcl-2 (p=0.0012) on HS+PTX group.	Hydrogen	93-95	BCL2, apoptosis regulator	Rattus norvegicus	73-78
25301772-7	2014	Docking experiments revealed that fluconazole and DTP binds in HSA mainly by hydrophobic interaction with the possibility of hydrogen bonds formation between the drugs and the residues Arg 222, Lys 199 and Lys 195 in HSA.	Hydrogen	125-133	albumin	Homo sapiens	217-220
25274121-5	2014	The most stable form of [GSNO + H](+), SN1, protonated at the amino group, presents a syn conformation at the S-N (partial) double bond and all peptidic carbonyls involved in (strong) C O   H-N hydrogen bonds, so allowing closure of a C5 (beta-strand), two C7 (gamma-turn), and one C9-membered rings.	Hydrogen	194-202	solute carrier family 38 member 3	Homo sapiens	39-42
24939171-5	2014	H2 S promotes the phosphorylation of AKT and ERK and increases the expression of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1).	Hydrogen	0-2	AKT serine/threonine kinase 1	Rattus norvegicus	37-40
24939171-5	2014	H2 S promotes the phosphorylation of AKT and ERK and increases the expression of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1).	Hydrogen	0-2	Eph receptor B1	Rattus norvegicus	45-48
24939171-7	2014	H2 S-treated astrocytes increased VEGF and Ang-1 expression, and the inhibition of phosphatidylinositide 3-kinase (PI3K)/AKT signaling by LY294002 significantly reduced H2 S-induced VEGF and Ang-1 expression in astrocytes.	Hydrogen	0-2	AKT serine/threonine kinase 1	Rattus norvegicus	121-124
24939171-8	2014	Finally, H2 S stimulated endothelial cell migration (3.92-fold increase in wound healing assay) and tube formation (3.69-fold increase, P &lt; 0.001) through PI3K/AKT signaling.	Hydrogen	9-11	AKT serine/threonine kinase 1	Rattus norvegicus	163-166
25218037-2	2014	PTH"s interaction with the N-terminal domain of PTH1 is mediated in part by Arg-20 on the peptide which forms a number of interactions with the receptor: a charge-charge interaction with Asp-137; hydrogen bonds with the backbone of Asp-29 and Met-32; and hydrophobic interactions with Met-32 and Gln-37.	Hydrogen	196-204	parathyroid hormone	Homo sapiens	0-3
25218037-2	2014	PTH"s interaction with the N-terminal domain of PTH1 is mediated in part by Arg-20 on the peptide which forms a number of interactions with the receptor: a charge-charge interaction with Asp-137; hydrogen bonds with the backbone of Asp-29 and Met-32; and hydrophobic interactions with Met-32 and Gln-37.	Hydrogen	196-204	parathyroid hormone	Homo sapiens	48-52
26702354-4	2014	The selection of experimental conditions evinces relevant changes with plasma pressure in the ion distributions dependence with the H2 fraction, particularly for the major ions: Ar+, ArH+ and H3+.	Hydrogen	132-134	low density lipoprotein receptor adaptor protein 1	Homo sapiens	183-186
26702354-6	2014	Nevertheless, a pronounced displacement of the ArH+ maximum towards the lowest H2 fractions is observed at 8 Pa, in detriment of Ar+, which becomes restricted to very small [H2]/([H2]+[Ar]) ratios, whereas H3+ becomes dominant for all [H2]/([H2]+[Ar]) &gt; 0.1.	Hydrogen	79-81	low density lipoprotein receptor adaptor protein 1	Homo sapiens	47-50
25254927-3	2014	The ligands were located deep inside the ligand binding pocket of the p110alpha subunit of PI3K, and the hydrogen bond formations and hydrophobic effects of the surrounding amino acids were predicted.	Hydrogen	105-113	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	70-79
24984238-5	2014	The results indicate that the inhibitors mainly interact with the S1 pocket of uPA, wherein the hydrogen bonds and the interactions between guanidines and the corresponding residues play an important role.	Hydrogen	96-104	plasminogen activator, urokinase	Homo sapiens	79-82
25216398-2	2014	We recently demonstrated that the frequent transmembrane association motif GASright, the GxxxG-containing fold of the glycophorin A dimer, is optimal for the formation of extended networks of Calpha-H hydrogen bonds, supporting the hypothesis that these bonds are major contributors to association.	Hydrogen	201-209	glycophorin A (MNS blood group)	Homo sapiens	118-131
25238648-0	2014	Effect of axial ligand, spin state, and hydrogen bonding on the inner-sphere reorganization energies of functional models of cytochrome P450.	Hydrogen	40-48	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	125-140
25238648-8	2014	The results suggest that while the hydrogen bonding to the thiolate in the 5C HS thiolate bound active site of cytochrome P450 (cyp450) shifts the potential up, resulting in a negative DeltaG, it also increases lambda resulting in an overall low barrier for the electron transfer process.	Hydrogen	35-43	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	111-126
25238648-8	2014	The results suggest that while the hydrogen bonding to the thiolate in the 5C HS thiolate bound active site of cytochrome P450 (cyp450) shifts the potential up, resulting in a negative DeltaG, it also increases lambda resulting in an overall low barrier for the electron transfer process.	Hydrogen	35-43	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	128-134
25285807-4	2014	The oxidation reactions mediated by CYP450 are known to occur by either a single electron transfer (SET) or a hydrogen atom transfer (HAT) mechanism.	Hydrogen	110-118	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	36-42
24984238-6	2014	Moreover, hydrogen bond analyses show the water-mediated hydrogen-bond network near the S1 pocket between uPA, and the ligand probably leads to excellent selectivity of these inhibitors on uPA.	Hydrogen	10-18	plasminogen activator, urokinase	Homo sapiens	106-109
24984238-6	2014	Moreover, hydrogen bond analyses show the water-mediated hydrogen-bond network near the S1 pocket between uPA, and the ligand probably leads to excellent selectivity of these inhibitors on uPA.	Hydrogen	10-18	plasminogen activator, urokinase	Homo sapiens	189-192
24984238-6	2014	Moreover, hydrogen bond analyses show the water-mediated hydrogen-bond network near the S1 pocket between uPA, and the ligand probably leads to excellent selectivity of these inhibitors on uPA.	Hydrogen	57-65	plasminogen activator, urokinase	Homo sapiens	106-109
24984238-6	2014	Moreover, hydrogen bond analyses show the water-mediated hydrogen-bond network near the S1 pocket between uPA, and the ligand probably leads to excellent selectivity of these inhibitors on uPA.	Hydrogen	57-65	plasminogen activator, urokinase	Homo sapiens	189-192
24928562-3	2014	However, in contrast with NO or CO, sulfide at concentrations lower than the toxic (muM) level is an hydrogen donor and a substrate for mitochondrial respiration.	Hydrogen	101-109	latexin	Homo sapiens	84-87
25029675-9	2014	Interleukin-6 increased at both post and 1h compared with pre (p &lt; 0.05) with no differences between conditions.	Hydrogen	41-43	interleukin 6	Homo sapiens	0-13
25392107-9	2014	The levels of TNF-alpha and NF-kappaB in the intestinal and lung tissues were significantly decreased in the HS group compared with those of the NS group.	Hydrogen	109-111	tumor necrosis factor	Rattus norvegicus	14-23
25143139-8	2014	The molecular property-affinity relationship reveals that the hydrogen bond force plays an important role in binding flavonoids to AChE.	Hydrogen	62-70	acetylcholinesterase (Cartwright blood group)	Homo sapiens	131-135
25103780-0	2014	Atmospheric formation of the NO3 radical from gas-phase reaction of HNO3 acid with the NH2 radical: proton-coupled electron-transfer versus hydrogen atom transfer mechanisms.	Hydrogen	140-148	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
24588097-0	2014	Temperature-dependent kinetics of charge transfer, hydrogen-atom transfer, and hydrogen-atom expulsion in the reaction of CO+ with CH4 and CD4.	Hydrogen	51-59	CD4 molecule	Homo sapiens	139-142
24588097-0	2014	Temperature-dependent kinetics of charge transfer, hydrogen-atom transfer, and hydrogen-atom expulsion in the reaction of CO+ with CH4 and CD4.	Hydrogen	79-87	CD4 molecule	Homo sapiens	139-142
24840541-10	2014	The H2O molecule in TCP-(H2O)1 sits on top of the binding pocket, donating both of its hydrogen atoms to the aromatic-rich interior of the monomer.	Hydrogen	87-95	serine peptidase inhibitor Kazal type 1	Homo sapiens	20-23
25172421-6	2014	In the molecular modelling study, compound 9i was bound in to the active pocket of EGFR with four hydrogen bonds and two pi-cation interactions having minimum binding energy DeltaGb=-54.4 kcal/mol.	Hydrogen	98-106	epidermal growth factor receptor	Homo sapiens	83-87
23982919-0	2014	Backbone 1H, 15N, and 13C and side chain 13Cbeta NMR chemical shift assignment of murine interleukin-10.	Hydrogen	9-11	interleukin 10	Mus musculus	89-103
25219901-0	2014	Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond.	Hydrogen	52-60	leucine rich repeat kinase 2	Homo sapiens	17-22
25287765-6	2014	Computational analysis of the docked complex revealed that phosphorylated pS1177 and pS615 have high affinity for Akt (one of the key kinases in the eNOS activation pathway), with a significant number of hydrogen bonds and salt bridges observed between these residues and Akt .	Hydrogen	204-212	AKT serine/threonine kinase 1	Homo sapiens	114-117
25287765-6	2014	Computational analysis of the docked complex revealed that phosphorylated pS1177 and pS615 have high affinity for Akt (one of the key kinases in the eNOS activation pathway), with a significant number of hydrogen bonds and salt bridges observed between these residues and Akt .	Hydrogen	204-212	AKT serine/threonine kinase 1	Homo sapiens	272-275
25108165-4	2014	Here, we demonstrate that significant elevation of IL-1beta occurs in the cortex as early as 1h after the beginning of reperfusion in rats subjected to 2-h middle cerebral artery occlusion (MCAo).	Hydrogen	93-95	interleukin 1 beta	Rattus norvegicus	51-59
24916702-5	2014	We also found these compounds underwent responsible hydrogen bonding to Arg120 and Ser353 in COX-2 active site residues.	Hydrogen	52-60	prostaglandin-endoperoxide synthase 2	Homo sapiens	93-98
25010574-0	2014	Hydroxyl radical recycling in isoprene oxidation driven by hydrogen bonding and hydrogen tunneling: the upgraded LIM1 mechanism.	Hydrogen	59-67	LIM homeobox 1	Homo sapiens	113-117
25010574-0	2014	Hydroxyl radical recycling in isoprene oxidation driven by hydrogen bonding and hydrogen tunneling: the upgraded LIM1 mechanism.	Hydrogen	80-88	LIM homeobox 1	Homo sapiens	113-117
25056872-0	2014	Electrochemical detection of DNA binding by tumor suppressor p53 protein using osmium-labeled oligonucleotide probes and catalytic hydrogen evolution at the mercury electrode.	Hydrogen	131-139	tumor protein p53	Homo sapiens	61-64
24666321-1	2014	Infrared multiple photon dissociation (IRMPD) spectra of NO3(-)(HNO3)m(H2O)n(H2)z with m = 1-3, up to n = 8 and z &gt;= 1, are measured in the fingerprint region (550-1880 cm(-1)), directly probing the NO-stretching modes, as well as bending and other lower frequency modes.	Hydrogen	71-73	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
24666321-5	2014	Addition of at least one more nitric acid molecule or two more water molecules weakens the hydrogen bond network, breaking the symmetry of this arrangement and leading to localization of the proton near one of the nitrate cores, effectively forming HNO3 hydrogen-bonded to NO3(-).	Hydrogen	91-99	NBL1, DAN family BMP antagonist	Homo sapiens	250-253
24666321-5	2014	Addition of at least one more nitric acid molecule or two more water molecules weakens the hydrogen bond network, breaking the symmetry of this arrangement and leading to localization of the proton near one of the nitrate cores, effectively forming HNO3 hydrogen-bonded to NO3(-).	Hydrogen	254-262	NBL1, DAN family BMP antagonist	Homo sapiens	250-253
24584703-2	2014	Loss of DDT was measured in anaerobic microcosms supplemented with H2, lactate, and acetate.	Hydrogen	67-69	D-dopachrome tautomerase	Homo sapiens	8-11
24196871-0	2014	Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells.	Hydrogen	15-23	thymoma viral proto-oncogene 1	Mus musculus	154-157
25205494-7	2014	The results indicated THR37, ALA42, ARG40 and ARG47 in P-glycoprotein are important determinant residues in binding as they have strong hydrogen bonding with Flavonoids.	Hydrogen	136-144	ATP binding cassette subfamily B member 1	Homo sapiens	55-69
24196871-0	2014	Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells.	Hydrogen	15-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	162-172
24196871-7	2014	Treatment with H2 decreased intracellular reactive oxygen species (ROS) formation, suppressed NADPH oxidase activity, down-regulated Rac1 activity and Nox1 expression, reduced mitochondrial ROS formation, and enhanced nuclear factor E2-related factor 2 nuclear translocation and heme oxygenase-1 activity.	Hydrogen	15-17	heme oxygenase 1	Mus musculus	279-295
24196871-9	2014	Furthermore, treatment with H2 suppressed NF-kappaB activation and reduced phosphorylation of p38, extracellular signal-regulated kinase, c-Jun-N-terminal kinase, and protein kinases B (AKT) stimulated with RANKL.	Hydrogen	28-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	42-51
24196871-9	2014	Furthermore, treatment with H2 suppressed NF-kappaB activation and reduced phosphorylation of p38, extracellular signal-regulated kinase, c-Jun-N-terminal kinase, and protein kinases B (AKT) stimulated with RANKL.	Hydrogen	28-30	thymoma viral proto-oncogene 1	Mus musculus	186-189
24196871-10	2014	In conclusion, hydrogen molecules prevented RANKL-induced osteoclast differentiation associated with inhibition of reactive oxygen species formation and inactivation of NF-kappaB, mitogen-activated protein kinase and AKT pathways.	Hydrogen	15-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	169-178
24196871-10	2014	In conclusion, hydrogen molecules prevented RANKL-induced osteoclast differentiation associated with inhibition of reactive oxygen species formation and inactivation of NF-kappaB, mitogen-activated protein kinase and AKT pathways.	Hydrogen	15-23	thymoma viral proto-oncogene 1	Mus musculus	217-220
25606441-10	2014	This study suggested that P84L and A94T variants of TNF-alpha could directly or indirectly destabilize the amino acid interactions and hydrogen bond networks thus explaining the functional deviations of protein to some extent.	Hydrogen	135-143	tumor necrosis factor	Homo sapiens	52-61
25044441-5	2014	The strength of hydrogen-bond complexes involving the fluorine moieties CH2F, CHF2, and CF3 was measured and characterized in simple systems by using established and novel NMR methods and compared to the known hydrogen-bond complex formed between acetophenone and p-fluorophenol.	Hydrogen	16-24	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	78-82
25230863-0	2014	[Role of Nrf2 in the protective effects of hydrogen against cerebral dysfunction in septic mice].	Hydrogen	43-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	9-13
25230863-1	2014	OBJECTIVE: To investigate the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in the protective effects of hydrogen against cerebral dysfunction in a mouse model of sepsis.	Hydrogen	118-126	nuclear factor, erythroid derived 2, like 2	Mus musculus	38-81
25230863-1	2014	OBJECTIVE: To investigate the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in the protective effects of hydrogen against cerebral dysfunction in a mouse model of sepsis.	Hydrogen	118-126	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
25230863-13	2014	CONCLUSIONS: Hydrogen inhalation can ameliorate pathological injury in brain and impairment of learning and memory abilities of septic mice, which may be associated with the up-regulation of Nrf2, the increase of antioxidant enzymes activities and the decrease of oxidative products.	Hydrogen	13-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	191-195
25165860-6	2014	Binding studies revealed that 3,6-DHF had a strong binding affinity to JNK1 (1.996 x 105 M-1) and that the 6-OH and the carbonyl oxygen of the C ring of 3,6-DHF participated in hydrogen bonding interactions with the carbonyl oxygen and the amide proton of Met111, respectively.	Hydrogen	177-185	mitogen-activated protein kinase 8	Homo sapiens	71-75
24880703-5	2014	Class B CpG ODN induced upregulation of TLR21 and IFN-gamma mRNA expression levels at 1h post-stimulation depending on concentration of ODN used but only in HG cells isolated from young birds.	Hydrogen	86-88	toll like receptor 21	Gallus gallus	40-45
24657643-2	2014	The prepared sensor exhibits a remarkable sensitivity of (16.18muA/muM) with a linear range of 5.0x10(-11)-5.0x10(-6)M and limit of detection as low as 1.0x10(-11)M in the detection of DA, which might be due to the plenty cavities for binding DA through pi-pi stacking between aromatic rings and hydrogen bonds between amino groups of DA and oxygen-containing groups of the novel PPy.	Hydrogen	296-304	latexin	Homo sapiens	67-70
26278096-5	2014	The evolution of the 2DIR line shape as a function of waiting time is well described in terms of the orientational dynamics of the water molecules, with chemical exchange cross peaks appearing at a time scale similar to the hydrogen bond rearrangement lifetime.	Hydrogen	224-232	arginine vasopressin receptor 2	Homo sapiens	22-25
25089037-11	2014	Hydroxyl, carbonyl or methoxy group also formed hydrogen bonds with residues in the adenine pocket and sugar pocket of HER2-TK.	Hydrogen	48-56	erb-b2 receptor tyrosine kinase 2	Homo sapiens	119-123
24931876-4	2014	These experimental data revealed that TiO2 nanoparticles could bind to catalase by the electrostatic and hydrogen bonding forces.	Hydrogen	105-113	catalase	Homo sapiens	71-79
25452862-6	2014	As compared with NGT 1h-low, NGT 1h-high and IGT subjects exhibited significantly higher body mass index (BMI), triglycerides, high sensitivity C reactive protein, ALT, GGT, and hepatic insulin resistance (IR), assessed by the liver IR index, as well as lower high density lipoprotein, and insulin-like growth factor-1 (IGF-1) levels.	Hydrogen	33-35	C-reactive protein	Homo sapiens	144-162
25452862-6	2014	As compared with NGT 1h-low, NGT 1h-high and IGT subjects exhibited significantly higher body mass index (BMI), triglycerides, high sensitivity C reactive protein, ALT, GGT, and hepatic insulin resistance (IR), assessed by the liver IR index, as well as lower high density lipoprotein, and insulin-like growth factor-1 (IGF-1) levels.	Hydrogen	33-35	insulin like growth factor 1	Homo sapiens	290-318
25452862-6	2014	As compared with NGT 1h-low, NGT 1h-high and IGT subjects exhibited significantly higher body mass index (BMI), triglycerides, high sensitivity C reactive protein, ALT, GGT, and hepatic insulin resistance (IR), assessed by the liver IR index, as well as lower high density lipoprotein, and insulin-like growth factor-1 (IGF-1) levels.	Hydrogen	33-35	insulin like growth factor 1	Homo sapiens	320-325
24875908-4	2014	The thermodynamic parameters revealed that CAT bound with hydrophobic pesticides by hydrophobic interaction force, and with hydrophilic pesticides by hydrogen bond and van der Waals force.	Hydrogen	150-158	catalase	Homo sapiens	43-46
24937348-10	2014	Furthermore, we found that the beneficial effects of hydrogen-rich saline treatment were associated with decreased levels of oxidative products (8-iso-prostaglandin F2alpha and malondialdehyde) and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and high-mobility group box protein 1), as well as the increased activity of antioxidant enzymes (superoxide dismutase and catalase) in serum and brain tissues.	Hydrogen	53-61	tumor necrosis factor	Rattus norvegicus	222-249
24937348-10	2014	Furthermore, we found that the beneficial effects of hydrogen-rich saline treatment were associated with decreased levels of oxidative products (8-iso-prostaglandin F2alpha and malondialdehyde) and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and high-mobility group box protein 1), as well as the increased activity of antioxidant enzymes (superoxide dismutase and catalase) in serum and brain tissues.	Hydrogen	53-61	interleukin 1 beta	Rattus norvegicus	251-268
24875908-5	2014	The pesticides to CAT molecular docking study showed that pesticides could enter into the cavity locating among the four subdomains of CAT, giving the specific amino acid residues and hydrogen bonds involved in CAT-pesticides interaction.	Hydrogen	184-192	catalase	Homo sapiens	18-21
24875908-5	2014	The pesticides to CAT molecular docking study showed that pesticides could enter into the cavity locating among the four subdomains of CAT, giving the specific amino acid residues and hydrogen bonds involved in CAT-pesticides interaction.	Hydrogen	184-192	catalase	Homo sapiens	135-138
24875908-5	2014	The pesticides to CAT molecular docking study showed that pesticides could enter into the cavity locating among the four subdomains of CAT, giving the specific amino acid residues and hydrogen bonds involved in CAT-pesticides interaction.	Hydrogen	184-192	catalase	Homo sapiens	135-138
24858299-9	2014	Moreover, the corresponding thermodynamical data showed that at pH&gt;6.5, van der Waals and hydrogen bonds due to aromatic amino acids as tyrosine or phenylalanine present in the N-terminal (NT) part governed the Abeta/HSPG association.	Hydrogen	93-101	amyloid beta precursor protein	Homo sapiens	214-219
24840884-1	2014	PURPOSE OF REVIEW: The purpose of this review is to describe the renin-angiotensin-aldosterone system and its regulatory control of sodium, potassium, chloride, hydrogen ion, and water homeostasis through its effects on the expression and activity of distal renal tubular cotransporter proteins and to discuss the gene mutations encoding these structures that disturb the function of this system.	Hydrogen	161-169	renin	Homo sapiens	65-70
25108730-0	2014	Electrochemical oxidation of 1H,1H,2H,2H-perfluorooctane sulfonic acid (6:2 FTS) on DSA electrode: operating parameters and mechanism.	Hydrogen	29-31	AKT interacting protein	Homo sapiens	76-79
25108730-0	2014	Electrochemical oxidation of 1H,1H,2H,2H-perfluorooctane sulfonic acid (6:2 FTS) on DSA electrode: operating parameters and mechanism.	Hydrogen	32-34	AKT interacting protein	Homo sapiens	76-79
24754906-6	2014	In addition, our studies showed the hydrogen bond occupation of the CDK8 A-loop increases during the first 20-ns MD simulation and stays stable during the later 30-ns MD simulation.	Hydrogen	36-44	cyclin dependent kinase 8	Homo sapiens	68-72
24754906-7	2014	Four residues in the A-loop of CDK8 have high hydrogen bond occupation, while the rest residues have low or no hydrogen bond occupation.	Hydrogen	46-54	cyclin dependent kinase 8	Homo sapiens	31-35
24754906-7	2014	Four residues in the A-loop of CDK8 have high hydrogen bond occupation, while the rest residues have low or no hydrogen bond occupation.	Hydrogen	111-119	cyclin dependent kinase 8	Homo sapiens	31-35
24929023-8	2014	IL-6 levels in the H2 group significantly decreased in 4 weeks by 37.3 +- 62.0% compared to baseline, whereas it increased by 33.6 +- 34.4% in the placebo group.	Hydrogen	19-21	interleukin 6	Homo sapiens	0-4
24929023-11	2014	After 4 weeks, MMP3 was significantly reduced by 19.2% +- 24.6% in the H2 group, and increased by 16.9% +- 50.2% in the placebo group.	Hydrogen	71-73	matrix metallopeptidase 3	Homo sapiens	15-19
24858299-10	2014	Abeta remained in its physiological structure in a random coil form (i.e. the non-amyloidogenic structure) because van der Waals interactions and hydrogen bonds were preponderant.	Hydrogen	146-154	amyloid beta precursor protein	Homo sapiens	0-5
24890947-0	2014	Hydrogen gas protects against serum and glucose deprivation-induced myocardial injury in H9c2 cells through activation of the NF-E2-related factor 2/heme oxygenase 1 signaling pathway.	Hydrogen	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	126-148
24123897-5	2014	Moreover, based on the sign and magnitude of the enthalpy and entropy changes (DeltaH(0)  = - 29.64 kcal/mol and DeltaS(0)  = - 69.51 cal/mol K) and the molecular docking results, it can be suggested that the main interaction forces of Cy-3-G with BSA are Van der Waals and hydrogen bonding interactions.	Hydrogen	274-282	albumin	Homo sapiens	248-251
24890947-13	2014	H2 gas-rich medium enhanced SGD-induced upregulation of HO-1 and Nrf2, and the HO-1 or Nrf2 inhibition partially suppressed H2 gas-induced cardioprotection.	Hydrogen	0-2	NFE2 like bZIP transcription factor 2	Rattus norvegicus	65-69
24890947-13	2014	H2 gas-rich medium enhanced SGD-induced upregulation of HO-1 and Nrf2, and the HO-1 or Nrf2 inhibition partially suppressed H2 gas-induced cardioprotection.	Hydrogen	124-126	NFE2 like bZIP transcription factor 2	Rattus norvegicus	87-91
24920673-10	2014	LC8 recognizes the signature TQT motif in the first LC8 binding site of Ana2, forming extensive van der Waals contacts and hydrogen bonding with the peptide, whereas the Ana2 site 2 TQC motif forms a uniquely extended beta-strand, not observed in other dynein light chain-target complexes.	Hydrogen	123-131	cut up	Drosophila melanogaster	0-3
24890947-14	2014	Furthermore, following genetic silencing of Nrf2 by RNA interference, the effects of H2 gas on the induction of HO-1 and cardioprotection were markedly reduced.	Hydrogen	85-87	NFE2 like bZIP transcription factor 2	Rattus norvegicus	44-48
24890947-15	2014	In conclusion, H2 gas protected cardiomyocytes from ischemia-induced myocardial injury through elimination of  OH free radicals and also through activation of the Nrf2/HO-1 signaling pathway.	Hydrogen	15-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	163-167
24965086-3	2014	When 2 was treated with two equivalents of a base under H2 or in 2-propanol, the hydrido complex 4 containing protic NHC and pyrazolato groups was obtained through metal-ligand cooperation.	Hydrogen	56-58	high mobility group nucleosomal binding domain 4	Homo sapiens	117-120
25014833-2	2014	DHFR from the cold-adapted organism Moritella profunda (MpDHFR) on the other hand is unable to form the two hydrogen bonds that stabilize the occluded conformation in EcDHFR and so remains in a closed conformation during catalysis.	Hydrogen	108-116	dihydrofolate reductase	Escherichia coli	0-4
25062251-4	2014	However, we could detect three changes, one each in the N-and C-terminus along with a small stretch in the middle of PEX19 (F64-L74) which became shielded from hydrogen exchange when interacting with PEX3.	Hydrogen	160-168	peroxisomal biogenesis factor 19	Homo sapiens	117-122
25062251-5	2014	PEX3 became more protected from hydrogen exchange in the binding groove for PEX19 with only small changes elsewhere.	Hydrogen	32-40	peroxisomal biogenesis factor 19	Homo sapiens	76-81
24798298-5	2014	The best hydrogen production rates (265mL/d/Lreactor) were obtained in the first block of experiments by MEC fed with 1500mg/L acetic acid and 250mg/L propionic acid.	Hydrogen	9-17	C-C motif chemokine ligand 28	Homo sapiens	105-108
25053321-2	2014	Using broadband two-dimensional infrared spectroscopy (2DIR), we have measured the influence of hydrogen bonding on the intermolecular vibrational coupling between dimerized N-methylacetamide molecules.	Hydrogen	96-104	arginine vasopressin receptor 2	Homo sapiens	56-59
24695861-3	2014	The MCM-22P material corresponds to the layers bound with relatively strong hydrogen bonds between surface silanol groups that is an energetically preferred structure in the presence of a structure directing agent (hexamethyleneimine).	Hydrogen	76-84	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	4-7
24710199-2	2014	The tutorial instructs the reader how to construct the VB diagrams and how to estimate HAT barriers from raw data, starting with the simplest reaction H + H2 and going all the way to HAT in the enzyme cytochrome P450.	Hydrogen	155-157	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	201-216
24945724-3	2014	Laser irradiation eliminates H2 from either Ru(PPh3)3(CO)(H)2 1 or cis-Ru(dppe)2(H)2 2 in C6D6 solution.	Hydrogen	29-31	caveolin 1	Homo sapiens	47-51
24740791-7	2014	ANG II induced threefold increases in phosphorylated MAP kinases ERK1/2 and a onefold increase in phosphorylated sodium and hydrogen exchanger 3 (NHE3) proteins, which were also blocked by losartan and megalin-siRNA.	Hydrogen	124-132	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
24740791-7	2014	ANG II induced threefold increases in phosphorylated MAP kinases ERK1/2 and a onefold increase in phosphorylated sodium and hydrogen exchanger 3 (NHE3) proteins, which were also blocked by losartan and megalin-siRNA.	Hydrogen	124-132	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	146-150
24905279-1	2014	Tungsten sulfides, including WS2 (crystalline) and WS3 (amorphous), were introduced to silicon nanowires, and both can promote the photoelectrochemical hydrogen production of silicon nanowires.	Hydrogen	152-160	dynactin subunit 6	Homo sapiens	51-54
24694997-4	2014	The performed calculations revealed that the nu(NH2) stretching, rho(NH2) rocking and tau(CH3) torsional modes are very sensitive to formation of the hydrogen bond between the DMA(+) cation and Ni-formate framework.	Hydrogen	150-158	rhodopsin	Homo sapiens	65-72
24811894-0	2014	Redox equilibration after one-electron reduction of cytochrome c oxidase: radical formation and a possible hydrogen relay mechanism.	Hydrogen	107-115	cytochrome c, somatic	Homo sapiens	52-64
24853767-4	2014	The results of molecular dynamics simulations indicate that hydrogen bonding interactions between the 7-azadindole moiety and the backbone groups of Cys673 are the most significant determinant for the potency and selectivity of c-KIT inhibitors.	Hydrogen	60-68	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	228-233
25062206-1	2014	The temperature-dependent diffusivity D(T) of hydrogen solute atoms trapped at dislocations-dislocation pipe diffusion of hydrogen-in deformed polycrystalline PdH(x) (x~10(-3)  [H]/[Pd]) has been quantified with quasielastic neutron scattering between 150 and 400 K. We observe diffusion coefficients for trapped hydrogen elevated by one to two orders of magnitude above bulk diffusion.	Hydrogen	46-54	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	159-162
25062206-1	2014	The temperature-dependent diffusivity D(T) of hydrogen solute atoms trapped at dislocations-dislocation pipe diffusion of hydrogen-in deformed polycrystalline PdH(x) (x~10(-3)  [H]/[Pd]) has been quantified with quasielastic neutron scattering between 150 and 400 K. We observe diffusion coefficients for trapped hydrogen elevated by one to two orders of magnitude above bulk diffusion.	Hydrogen	122-130	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	159-162
25062206-1	2014	The temperature-dependent diffusivity D(T) of hydrogen solute atoms trapped at dislocations-dislocation pipe diffusion of hydrogen-in deformed polycrystalline PdH(x) (x~10(-3)  [H]/[Pd]) has been quantified with quasielastic neutron scattering between 150 and 400 K. We observe diffusion coefficients for trapped hydrogen elevated by one to two orders of magnitude above bulk diffusion.	Hydrogen	122-130	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	159-162
24905279-3	2014	Polarization curves of WS3 and WS2 suggest that WS3 has higher catalytic activity in the hydrogen evolution reaction than WS2, affording higher energy conversion efficiency in silicon nanowires decorated with WS3.	Hydrogen	89-97	dynactin subunit 6	Homo sapiens	48-51
24905279-3	2014	Polarization curves of WS3 and WS2 suggest that WS3 has higher catalytic activity in the hydrogen evolution reaction than WS2, affording higher energy conversion efficiency in silicon nanowires decorated with WS3.	Hydrogen	89-97	dynactin subunit 6	Homo sapiens	48-51
24938297-6	2014	Higher hydrogen content in the sewage sludge (from SS1) affected the produced gas composition, which was characterized by high concentrations of combustible components.	Hydrogen	7-15	major histocompatibility complex, class II, DR beta 1	Homo sapiens	51-54
24893807-5	2014	The BF2-bound fluorohydrin yields the reaction product through a concerted process involving fluoride transfer from the C-F bond to the OBF2 group and hydrogen or alkyl group migration, as first demonstrated in this work.	Hydrogen	151-159	forkhead box G1	Homo sapiens	4-7
24951883-10	2014	We also discovered that hydrogen-rich saline not 2.5 ml/kg but 5 and 10 ml/kg could dose-dependently attenuate mechanical and thermal hyperalgesia without affecting baseline nociceptive threshold, reduce expressions of inflammatory mediators (TNF-alpha, IL-1beta, and IL-6) and decrease NR1 trafficking mediated by GSK-3beta, and minimal effective concentration was observed to be higher than 10 mumol/L, namely peak concentration in arterial blood after administration of HRS 2.5 ml/kg without any influence on hyperalgesia.	Hydrogen	24-32	tumor necrosis factor	Rattus norvegicus	243-252
24951883-10	2014	We also discovered that hydrogen-rich saline not 2.5 ml/kg but 5 and 10 ml/kg could dose-dependently attenuate mechanical and thermal hyperalgesia without affecting baseline nociceptive threshold, reduce expressions of inflammatory mediators (TNF-alpha, IL-1beta, and IL-6) and decrease NR1 trafficking mediated by GSK-3beta, and minimal effective concentration was observed to be higher than 10 mumol/L, namely peak concentration in arterial blood after administration of HRS 2.5 ml/kg without any influence on hyperalgesia.	Hydrogen	24-32	interleukin 1 beta	Rattus norvegicus	254-262
24951883-10	2014	We also discovered that hydrogen-rich saline not 2.5 ml/kg but 5 and 10 ml/kg could dose-dependently attenuate mechanical and thermal hyperalgesia without affecting baseline nociceptive threshold, reduce expressions of inflammatory mediators (TNF-alpha, IL-1beta, and IL-6) and decrease NR1 trafficking mediated by GSK-3beta, and minimal effective concentration was observed to be higher than 10 mumol/L, namely peak concentration in arterial blood after administration of HRS 2.5 ml/kg without any influence on hyperalgesia.	Hydrogen	24-32	interleukin 6	Rattus norvegicus	268-272
24974084-4	2014	Rigid and induced fit docking protocols were applied on ALR protein for both with and without NADP+ cofactor to identify a suitable binding mode that facilitates the key hydrogen bond interactions with Tyr48.	Hydrogen	170-178	aldo-keto reductase family 1 member B	Homo sapiens	56-59
25016257-5	2014	(1) The 1H-NMR signals at ~5.5, 4-8, 7.4-10.2, and 12.22-12.37 ppm were attributed to the chemical shifts of active protons on carbons adjacent to R-OH, RAr-OH, oximes, and -COOH, respectively.	Hydrogen	8-10	RAB40B, member RAS oncogene family	Homo sapiens	153-156
25095616-8	2014	CONCLUSION: The reduced expressions of CBS and CSE may inhibit the H2 S signaling pathway, which might be one of the mechanisms underlying androgen deficiency-induced ED in rats.	Hydrogen	67-69	cystathionine beta synthase	Rattus norvegicus	39-42
24898776-10	2014	Au-Pd octahedra with two different core sizes and shell thicknesses have been used for hydrogen sensing by comparing their UV-vis spectra before and after hydrogen incorporation forming PdH.	Hydrogen	87-95	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	186-189
24898776-10	2014	Au-Pd octahedra with two different core sizes and shell thicknesses have been used for hydrogen sensing by comparing their UV-vis spectra before and after hydrogen incorporation forming PdH.	Hydrogen	155-163	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	186-189
25112032-4	2014	This biocathode MEC has been used for simultaneous hydrogen production and wastewater treatment.	Hydrogen	51-59	C-C motif chemokine ligand 28	Homo sapiens	16-19
25112032-6	2014	At an applied voltage of 0.9 V, the biocathode MEC achieved a hydrogen production rate of 0.39 m3 m(-3) d(-1), with a current density of 134 Am(-3), chemical oxygen demand (COD) removal of 90%, a coulombic efficiency of 63%, a cathodic hydrogen recovery of 37%, and an energy efficiency based on an electricity input of 67%.	Hydrogen	62-70	C-C motif chemokine ligand 28	Homo sapiens	47-50
25112032-6	2014	At an applied voltage of 0.9 V, the biocathode MEC achieved a hydrogen production rate of 0.39 m3 m(-3) d(-1), with a current density of 134 Am(-3), chemical oxygen demand (COD) removal of 90%, a coulombic efficiency of 63%, a cathodic hydrogen recovery of 37%, and an energy efficiency based on an electricity input of 67%.	Hydrogen	236-244	C-C motif chemokine ligand 28	Homo sapiens	47-50
24836068-8	2014	Thorough docking calculations of the seven most potent AChE inhibitors from the set, showed that the hydrogen bond can be formed between amide -NH- moiety of compounds and -OH group of Tyr 124.	Hydrogen	101-109	acetylcholinesterase (Cartwright blood group)	Homo sapiens	55-59
24838246-5	2014	Mutational analysis coupled with molecular modeling and molecular dynamics analysis reveals that although hydrogen bonding to O2 of uracil underlies the UDG activity in a dissociative fashion, Tth UDGb relies on multiple catalytic residues to facilitate its excision of hypoxanthine and xanthine.	Hydrogen	106-114	uracil-DNA glycosylase	Thermus thermophilus HB8	153-156
24794108-8	2014	The hydroxyl group on compound 11k possibly contributed to the formation of hydrogen bond between DDC and the inhibitor.	Hydrogen	76-84	dopa decarboxylase	Homo sapiens	98-101
24927549-4	2014	Catch bonds arise due to force-induced remodeling of hydrogen bond networks, a finding that also accounts for unbinding in structurally unrelated integrin-fibronectin and actomyosin complexes.	Hydrogen	53-61	fibronectin 1	Homo sapiens	155-166
24927549-6	2014	A similar transition allows us to predict the increase in the number of hydrogen bonds in a particular allosteric state of alpha5beta1 integrin-fibronectin complex, a conformation which is yet to be crystallized.	Hydrogen	72-80	fibronectin 1	Homo sapiens	144-155
24853114-8	2014	The free energy for H2 addition (DeltaG H2) to [CpRe(PPh3)(NO)(CO)](+) (+15 kcal mol(-1)) was identified as the most significant thermodynamic impediment for the reduction of CO. DFT computations on a series of [Cp(X)M(L)(NO)(CO)](+) (M = Re, Mn) complexes indicate that DeltaG H2 can be varied by 11 kcal mol(-1) through variation of both the ancillary ligands and the metal.	Hydrogen	20-22	caveolin 1	Homo sapiens	53-57
24853114-8	2014	The free energy for H2 addition (DeltaG H2) to [CpRe(PPh3)(NO)(CO)](+) (+15 kcal mol(-1)) was identified as the most significant thermodynamic impediment for the reduction of CO. DFT computations on a series of [Cp(X)M(L)(NO)(CO)](+) (M = Re, Mn) complexes indicate that DeltaG H2 can be varied by 11 kcal mol(-1) through variation of both the ancillary ligands and the metal.	Hydrogen	40-42	caveolin 1	Homo sapiens	53-57
24853114-8	2014	The free energy for H2 addition (DeltaG H2) to [CpRe(PPh3)(NO)(CO)](+) (+15 kcal mol(-1)) was identified as the most significant thermodynamic impediment for the reduction of CO. DFT computations on a series of [Cp(X)M(L)(NO)(CO)](+) (M = Re, Mn) complexes indicate that DeltaG H2 can be varied by 11 kcal mol(-1) through variation of both the ancillary ligands and the metal.	Hydrogen	40-42	caveolin 1	Homo sapiens	53-57
24873989-2	2014	The latter complex, in combination with B(C6F5)3, reacts with ArO-H substrates via formal hydrogen-atom transfer and exhibits dramatically increased reaction rates over the Mn(V)(O) starting material.	Hydrogen	90-98	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	62-65
25392748-4	2014	Insulin sensitivity (Si) was determined by a 2-stage glucose clamp, liver and intramyocellular lipid by 1H-MR spectroscopy and body composition by DEXA.	Hydrogen	104-106	insulin	Homo sapiens	0-7
24828006-5	2014	Further structure-activity relationship studies of the most active PXR antagonist from the series (compound 20, IC50 = 11 muM) revealed the importance of hydroxyl groups as hydrogen-bond donors for PXR antagonistic activity.	Hydrogen	173-181	nuclear receptor subfamily 1 group I member 2	Homo sapiens	67-70
24828006-5	2014	Further structure-activity relationship studies of the most active PXR antagonist from the series (compound 20, IC50 = 11 muM) revealed the importance of hydroxyl groups as hydrogen-bond donors for PXR antagonistic activity.	Hydrogen	173-181	nuclear receptor subfamily 1 group I member 2	Homo sapiens	198-201
24891603-4	2014	The sodium/hydrogen exchanger 1 (NHE-1) is linked to the cytoskeleton by ezrin/radixin/moesin family proteins and is known to regulate invadopodium-mediated matrix degradation.	Hydrogen	11-19	solute carrier family 9 member A1	Homo sapiens	33-38
24891603-4	2014	The sodium/hydrogen exchanger 1 (NHE-1) is linked to the cytoskeleton by ezrin/radixin/moesin family proteins and is known to regulate invadopodium-mediated matrix degradation.	Hydrogen	11-19	moesin	Homo sapiens	87-93
24813944-5	2014	The structure reveals that the conformation of a phenylalanine allows the formation of an optimal 5hmC binding pocket, and a hydrogen bond between the hydroxyl group of 5hmC and UHRF2-SRA is critical for their preferential binding.	Hydrogen	125-133	ubiquitin like with PHD and ring finger domains 2	Homo sapiens	178-187
24002363-0	2014	Conversion rate of para-hydrogen to ortho-hydrogen by oxygen: implications for PHIP gas storage and utilization.	Hydrogen	19-32	pleckstrin homology domain interacting protein	Homo sapiens	79-83
24717679-8	2014	A molecular docking analysis indicated that metformin might interact with CAT via hydrogen bonds.	Hydrogen	82-90	catalase	Mus musculus	74-77
24901528-5	2014	The critical interaction governing absorption of chitosan beads to KTI and lectin could be hydrogen bonding.	Hydrogen	91-99	LOW QUALITY PROTEIN: lectin	Glycine max	75-81
24704898-1	2014	We investigate whether a novel and inexpensive etching method, H3PO4 + NaF, on titanium could obtain both a lower hydrogen content and superior calcium phosphate deposition performance, while achieving similar surface roughness in comparison with the traditional etching method.	Hydrogen	114-122	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
24767840-3	2014	Using a fragment-based in silico screening approach, we identified two small molecules that bind to the first bromodomain of BRD4 with low-micromolar affinity and favorable ligand efficiency (0.37 kcal/mol per non-hydrogen atom), selectively over other families of bromodomains.	Hydrogen	214-222	bromodomain containing 4	Homo sapiens	125-129
24373283-8	2014	(4) This scaffold of inhibitors may bind to the B-Raf kinase with an "L" conformation and belong to type III binding mode, which is fixed by hydrophobic interaction and hydrogen bonds with residues from hinge region and DFG motif.	Hydrogen	169-177	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	48-53
24673410-11	2014	In conclusion, H2 S donors protected BBB integrity following experimental stroke possibly by acting through NF-kappaB inhibition to suppress neuroinflammation induction of MMP9 and NOX4-derived free radicals.	Hydrogen	15-17	nuclear factor kappa B subunit 1	Homo sapiens	108-117
24881485-3	2014	Observations of the structural transformation of NO3 salt indicated that a pseudo crystalline phase transformation takes place through concerted ligand-exchange reactions at the four Ni(II) centers of the macrocycle with hydrogen bond switching.	Hydrogen	221-229	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
24898969-2	2014	A combination of N-H   N, C-H   N and C-H   O hydrogen bonds links the molecules into sheets, in which the hydrogen bonds occupy the central layer with the tert-butyl and octyl groups arranged on either side, such that the closest contacts between adjacent sheets involve only the octyl groups.	Hydrogen	107-115	nuclear receptor subfamily 4 group A member 3	Homo sapiens	26-41
24002363-0	2014	Conversion rate of para-hydrogen to ortho-hydrogen by oxygen: implications for PHIP gas storage and utilization.	Hydrogen	24-32	pleckstrin homology domain interacting protein	Homo sapiens	79-83
24002363-3	2014	RESULTS: The para-hydrogen to ortho-hydrogen velocity constant, k, near room temperature (292 K) was determined to be 8.27 +- 1.30 L/mol   min(-1).	Hydrogen	18-26	CD59 molecule (CD59 blood group)	Homo sapiens	139-145
24002363-3	2014	RESULTS: The para-hydrogen to ortho-hydrogen velocity constant, k, near room temperature (292 K) was determined to be 8.27 +- 1.30 L/mol   min(-1).	Hydrogen	36-44	CD59 molecule (CD59 blood group)	Homo sapiens	139-145
24710069-7	2014	Modeling suggests that the two hydrogen bonds between the highly conserved residues Ser-528 and glycine-525 are required for PDRP-mediated phosphorylation of the active-site Thr-527 of PPDK.	Hydrogen	31-39	pyruvate, phosphate dikinase regulatory protein, chloroplastic	Zea mays	125-129
24652202-9	2014	Ligplot shows hydrogen bondings (S16, S17, V18, G19, K20, T21, S22, S31, T33, A35, S38, T39 and G65) and hydrophobic interacting residues (F25, F32, P34, F36, V37, D62 and A64) with the GTP ligands in the binding site of Rab3A protein.	Hydrogen	14-22	keratin 20	Homo sapiens	53-56
24413285-0	2014	Control of cytochrome c redox reactivity through off-pathway modifications in the protein hydrogen-bonding network.	Hydrogen	90-98	cytochrome c, somatic	Homo sapiens	11-23
24905512-6	2014	However, when TNFalpha was injected 1h, but not 6h, before liver perfusion it completely abolished (p&lt;0.05) the suppressive effect of 20 muU/mL insulin on HGP and glycogenolysis stimulated by cAMP.	Hydrogen	36-38	tumor necrosis factor	Rattus norvegicus	14-22
24912641-0	2014	[The role of Nrf2 in the hydrogen treatment for intestinal injury caused by severe sepsis].	Hydrogen	25-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
24912641-1	2014	OBJECTIVE: To investigate the role of Nrf2 on hydrogen treatment for intestinal injury caused by severe sepsis.	Hydrogen	46-54	nuclear factor, erythroid derived 2, like 2	Mus musculus	38-42
24912641-15	2014	CONCLUSIONS: Through activation of Nrf2-antioxidant response element (ARE) pathway, hydrogen may increase the level of Nrf2, which is a kind of protective protein, in the intestine of mice, thus decreases the level of late pro-inflammatory factor, HMGB1, and it may protect the intestinal tissues in septic mice and increase the survival rate significantly.	Hydrogen	84-92	nuclear factor, erythroid derived 2, like 2	Mus musculus	35-39
24912641-15	2014	CONCLUSIONS: Through activation of Nrf2-antioxidant response element (ARE) pathway, hydrogen may increase the level of Nrf2, which is a kind of protective protein, in the intestine of mice, thus decreases the level of late pro-inflammatory factor, HMGB1, and it may protect the intestinal tissues in septic mice and increase the survival rate significantly.	Hydrogen	84-92	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
24710036-0	2014	A supramolecular Co(II)14-metal-organic cube in a hydrogen-bonded network and a Co(II)-organic framework with a flexible methoxy substituent.	Hydrogen	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
24710036-1	2014	The reaction of 4,5-dicyano-2-methoxyimidazole (L1) with Co(NO3)2 6H2O under solvothermal conditions in DMF, a MOF, and a hydrogen-bonded network consisting of tetradecanuclear Co(ii)14-metal organic cube () are achieved.	Hydrogen	122-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
24733882-11	2014	Together, these results define a main branch of H2-regulated stomatal movement involved in the ABA signaling cascade in which RbohF-dependent ROS and nitric reductase-associated NO production, and subsequent GORK activation, were causally involved.	Hydrogen	48-50	gated outwardly-rectifying K+ channel	Arabidopsis thaliana	208-212
24410726-7	2014	We found that the hydrogen bond density in thermophilic Fe-SOD was higher than that in mesophilic Fe- SOD.	Hydrogen	18-26	superoxide dismutase 1	Homo sapiens	59-62
24410726-7	2014	We found that the hydrogen bond density in thermophilic Fe-SOD was higher than that in mesophilic Fe- SOD.	Hydrogen	18-26	superoxide dismutase 1	Homo sapiens	102-105
24410726-8	2014	In addition, larger hydrogen bond networks that involve more waters covered the thermophilic Fe-SOD.	Hydrogen	20-28	superoxide dismutase 1	Homo sapiens	96-99
25190158-16	2014	These missense variants were predicted to cause change of human MCC protein side chain structure by changing hydrogen bonding, size of amino acid residue and electric charge, and predicted to damage the protein function possibly according to PolyPhen-2 and PDB analysis.	Hydrogen	109-117	MCC regulator of WNT signaling pathway	Homo sapiens	64-67
24853453-4	2014	18alpha-GAMG was firstly nicely bound to epidermal growth factor receptor (EGFR) via six hydrogen bonds and one charge interaction, and the docking calculation proved the correlation between anticancer activities and EGFR inhibitory activities.	Hydrogen	89-97	epidermal growth factor receptor	Homo sapiens	41-73
24823262-2	2014	These species were chosen as simple and computationally tractable models of the Co(III)-hydrido compounds that are known to be important intermediates in the catalytic cycles of hydrogen evolution mediated by the cobaloxime complexes.	Hydrogen	178-186	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	80-87
24853453-4	2014	18alpha-GAMG was firstly nicely bound to epidermal growth factor receptor (EGFR) via six hydrogen bonds and one charge interaction, and the docking calculation proved the correlation between anticancer activities and EGFR inhibitory activities.	Hydrogen	89-97	epidermal growth factor receptor	Homo sapiens	75-79
24687770-2	2014	The resulting intermediates react further in a variety of ways to form products of nucleophilic substitution of a halogen atom (SN Ar), a hydrogen atom (SN ArH), and others.	Hydrogen	138-146	low density lipoprotein receptor adaptor protein 1	Homo sapiens	156-159
24634922-0	2014	New perspectives in hydrogen storage based on RCH2NH2/RCN couples.	Hydrogen	20-28	reticulocalbin 1	Homo sapiens	54-57
24634922-1	2014	A recent breakthrough in primary amine dehydrogenation by an oxidant-free process, and without any hydrogen acceptor, opens the possibility for RCH2NH2/RCN couples to be considered as potential hydrogen energy carriers.	Hydrogen	41-49	reticulocalbin 1	Homo sapiens	152-155
24634922-1	2014	A recent breakthrough in primary amine dehydrogenation by an oxidant-free process, and without any hydrogen acceptor, opens the possibility for RCH2NH2/RCN couples to be considered as potential hydrogen energy carriers.	Hydrogen	99-107	reticulocalbin 1	Homo sapiens	152-155
24725156-0	2014	Charge clamps of lysines and hydrogen bonds play key roles in the mechanism to fix helix 12 in the agonist and antagonist positions of estrogen receptor alpha: intramolecular interactions studied by the ab initio fragment molecular orbital method.	Hydrogen	29-37	estrogen receptor 1	Homo sapiens	135-158
24749673-0	2014	Theoretical kinetics study of the O(3P) + CH4/CD4 hydrogen abstraction reaction: the role of anharmonicity, recrossing effects, and quantum mechanical tunneling.	Hydrogen	50-58	CD4 molecule	Homo sapiens	46-49
24648384-7	2014	The predicted non-conservative amino acid substitution, p.Trp207Gly, disrupts a crucial hydrogen bond in the calcium-binding region of the catalytic domain of the matrix metalloproteinase, MMP13.	Hydrogen	88-96	matrix metallopeptidase 13	Homo sapiens	189-194
24325603-5	2014	X-ray structures revealed that ribavirin and lamivudine bind in IIA subdomain of HSA mainly by forming hydrogen bond and hydrophobic interactions forces.	Hydrogen	103-111	albumin	Homo sapiens	81-84
24467325-9	2014	The reduced hydroquinone form of RF-Id (RED-RF-Id) was a more potent inhibitor of 5-LOX as it had more bidirectional hydrogen bonds within the 5-LOX substrate binding site.	Hydrogen	117-125	arachidonate 5-lipoxygenase	Homo sapiens	82-87
24797088-5	2014	With deeper investigation on the DNA:BAF structures, the hydrogen bonds are found to make great contribution to the interaction between DNA and BAF.	Hydrogen	57-65	BAF nuclear assembly factor 1	Homo sapiens	37-40
24797088-5	2014	With deeper investigation on the DNA:BAF structures, the hydrogen bonds are found to make great contribution to the interaction between DNA and BAF.	Hydrogen	57-65	BAF nuclear assembly factor 1	Homo sapiens	144-147
24534729-2	2014	Studies of the mitogen-activated protein kinase ERK2 (extracellular-regulated protein kinase 2) by hydrogen-exchange mass spectrometry suggest that activation enhances backbone flexibility at the linker between N- and C-terminal domains while altering nucleotide binding mode.	Hydrogen	99-107	mitogen-activated protein kinase 1	Homo sapiens	48-52
24797088-6	2014	The hydrogen bonds in DNA:BAF (MT) are fewer than those in DNA:BAF (WT), indicating that the Gly25Glu mutation in BAF has an important effect on the hydrogen bonds in the DNA:BAF complex.	Hydrogen	4-12	BAF nuclear assembly factor 1	Homo sapiens	26-29
24534729-2	2014	Studies of the mitogen-activated protein kinase ERK2 (extracellular-regulated protein kinase 2) by hydrogen-exchange mass spectrometry suggest that activation enhances backbone flexibility at the linker between N- and C-terminal domains while altering nucleotide binding mode.	Hydrogen	99-107	mitogen-activated protein kinase 1	Homo sapiens	54-94
24797088-6	2014	The hydrogen bonds in DNA:BAF (MT) are fewer than those in DNA:BAF (WT), indicating that the Gly25Glu mutation in BAF has an important effect on the hydrogen bonds in the DNA:BAF complex.	Hydrogen	149-157	BAF nuclear assembly factor 1	Homo sapiens	26-29
24797088-6	2014	The hydrogen bonds in DNA:BAF (MT) are fewer than those in DNA:BAF (WT), indicating that the Gly25Glu mutation in BAF has an important effect on the hydrogen bonds in the DNA:BAF complex.	Hydrogen	149-157	BAF nuclear assembly factor 1	Homo sapiens	63-66
24797088-6	2014	The hydrogen bonds in DNA:BAF (MT) are fewer than those in DNA:BAF (WT), indicating that the Gly25Glu mutation in BAF has an important effect on the hydrogen bonds in the DNA:BAF complex.	Hydrogen	149-157	BAF nuclear assembly factor 1	Homo sapiens	63-66
24797088-6	2014	The hydrogen bonds in DNA:BAF (MT) are fewer than those in DNA:BAF (WT), indicating that the Gly25Glu mutation in BAF has an important effect on the hydrogen bonds in the DNA:BAF complex.	Hydrogen	149-157	BAF nuclear assembly factor 1	Homo sapiens	63-66
24608274-1	2014	In situ X-ray diffraction measurements reveal that the transformation of a AuCu nanoalloy from a face-centered-cubic to an L10 structure is accelerated under a hydrogen atmosphere.	Hydrogen	160-168	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	123-126
23397434-3	2014	This review focuses on the study of molecular complexes, design of which is inspired by the components of natural photosynthesis, and covers research from early triad reaction centers developed by the group of Gust, Moore, and Moore to recent photoelectrochemical systems capable of using light to convert water to oxygen and hydrogen.	Hydrogen	326-334	GUST	Homo sapiens	210-214
24763696-0	2014	Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway.	Hydrogen	26-34	AKT serine/threonine kinase 1	Rattus norvegicus	165-168
24763696-5	2014	In the present study, we aimed to evaluate whether hydrogen alleviates EBI after SAH, specifically neuronal apoptosis, partially via the Akt/GSK3beta signaling pathway.	Hydrogen	51-59	AKT serine/threonine kinase 1	Rattus norvegicus	137-140
24738575-4	2014	By exposing Pd powder to dilute hydrogen in nitrogen gas, sacrificial surface PdH is formed along with a controlled amount of dilute interstitial hydride.	Hydrogen	32-40	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	78-81
24860394-7	2014	These dimers are linked via C-H O hydrogen bonds involving the nitro O atoms, forming A-A-A and B-B-B slabs that lie parallel to one another and to (010).	Hydrogen	34-42	amyloid beta precursor protein	Homo sapiens	86-101
24508873-7	2014	In addition, the molecular modeling study of BSA-BMOP system shows that BMOP binds with BSA at the interface between two sub domains IIA and IIIA, which is located just above the entrance of the binding pocket of IIA through hydrophobic and hydrogen bond interactions in which hydrophobic interaction are dominated.	Hydrogen	241-249	albumin	Homo sapiens	45-48
24508873-7	2014	In addition, the molecular modeling study of BSA-BMOP system shows that BMOP binds with BSA at the interface between two sub domains IIA and IIIA, which is located just above the entrance of the binding pocket of IIA through hydrophobic and hydrogen bond interactions in which hydrophobic interaction are dominated.	Hydrogen	241-249	albumin	Homo sapiens	88-91
24779061-5	2014	The structure of SA1 was confirmed by single crystal X-ray diffraction and its binding with Al3+ was studied in detail using UVvisible, fluorescence and 1H NMR spectral studies along with mass determination.	Hydrogen	153-155	stromal antigen 1	Homo sapiens	17-20
24608976-0	2014	A novel tescalcin-sodium/hydrogen exchange axis underlying sorafenib resistance in FLT3-ITD+ AML.	Hydrogen	25-33	fms related receptor tyrosine kinase 3	Homo sapiens	83-87
24601644-0	2014	Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.	Hydrogen	55-63	tumor protein p53	Homo sapiens	29-32
24732091-3	2014	OBJECTIVE: The purpose of this study was to test the accuracy of NAFLD liver fat score (NAFLD-LFS), hepatic steatosis index (HSI) and fatty liver index (FLI) against 1H-MRS and their relationships with insulin sensitivity and secretion.	Hydrogen	166-168	insulin	Homo sapiens	202-209
24625033-6	2014	By comparing the oxysterol profile formed from 7-DHC and those formed from 8-DHC and 5,8(14)-dienol, products formed from abstraction of the hydrogen atoms at C-9 and C-14 (H-9 or H-14 mechanism) were clearly differentiated.	Hydrogen	141-149	G protein-coupled receptor 50	Homo sapiens	173-176
24607998-6	2014	In the molecular modeling study, compound 7k was bound in to the active pocket of EGFR with three hydrogen bond and one pi-cation interaction with minimum binding energy DeltaGb = -54.6913 kcal/mol, as well as compound 7b was bound in to the active site of FabH with hydrogen bond and pi-sigma interactions with minimum binding energy DeltaGb = -45.9125 kcal/mol.	Hydrogen	98-106	epidermal growth factor receptor	Homo sapiens	82-86
24607998-6	2014	In the molecular modeling study, compound 7k was bound in to the active pocket of EGFR with three hydrogen bond and one pi-cation interaction with minimum binding energy DeltaGb = -54.6913 kcal/mol, as well as compound 7b was bound in to the active site of FabH with hydrogen bond and pi-sigma interactions with minimum binding energy DeltaGb = -45.9125 kcal/mol.	Hydrogen	267-275	epidermal growth factor receptor	Homo sapiens	82-86
24589657-3	2014	In human CPR, His(322) forms a hydrogen-bond with the highly conserved Asp(677), a member of the catalytic triad.	Hydrogen	31-39	cytochrome p450 oxidoreductase	Homo sapiens	9-12
32261517-2	2014	1H NMR and fluorescence analyses revealed that BCC binds to insulin through electrostatic and host-guest interactions.	Hydrogen	0-2	insulin	Homo sapiens	60-67
24635163-2	2014	In this Communication, a potent boron-doped Pd nanocatalyst (Pd-B/C) is reported for the first time to boost hydrogen generation at room temperature from aqueous formic acid-formate solutions at a record high rate.	Hydrogen	109-117	PDB1	Homo sapiens	61-67
23179060-0	2014	Backbone and side-chain 1H, 15N and 13C assignments of mouse peptide ESP4.	Hydrogen	24-26	exocrine gland secreted peptide 4	Mus musculus	69-73
23212441-0	2014	Backbone 1H, 13C and 15N resonance assignments of human vaccinia-related kinase 1 (VRK1).	Hydrogen	9-11	VRK serine/threonine kinase 1	Homo sapiens	56-81
23417793-0	2014	1H, 13C and 15N resonance assignments of an N-terminal domain of CHD4.	Hydrogen	0-2	chromodomain helicase DNA binding protein 4	Homo sapiens	65-69
23212441-0	2014	Backbone 1H, 13C and 15N resonance assignments of human vaccinia-related kinase 1 (VRK1).	Hydrogen	9-11	VRK serine/threonine kinase 1	Homo sapiens	83-87
24059299-3	2014	Hydrophobic interactions and hydrogen bonds both play an equally important role in the correct positioning of Huperzine-B within the "catalytic site" of AChE to permit docking.	Hydrogen	29-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	153-157
23640000-0	2014	Sequence-specific backbone 1H, 13C and 15N assignments of the 34 kDa catalytic domain of PTPN5 (STEP).	Hydrogen	27-29	protein tyrosine phosphatase, non-receptor type 5	Mus musculus	89-94
24474703-4	2014	The loss of a key hydrogen bond between the oxygen atom of the furanyl ring of the agonist and Thr 574 in TLR8 suggested that the furan ring is dispensable.	Hydrogen	18-26	toll like receptor 8	Homo sapiens	106-110
24059300-3	2014	It was found that hydrophobic interactions play an important role in the correct positioning of BNC within the "catalytic site" of AChE, BuChE and 5-LPO to permit docking while hydrogen bonds are significant in case of cymserine for the same.	Hydrogen	177-185	acetylcholinesterase (Cartwright blood group)	Homo sapiens	131-135
24280687-12	2014	The expression of PGI2 synthase and COX-2 in the HS group was significantly higher compared with the SD and BS groups (P &lt; 0.01).	Hydrogen	49-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	36-41
24486832-5	2014	The spectral data indicated that the nanoparticle could spontaneously form a reversible complex with bovine serum albumin in solution used mainly by hydrogen bonds and van der Waals forces.	Hydrogen	149-157	albumin	Homo sapiens	108-121
24633771-4	2014	The conserved hydrophobic adenine region of PI3Kalpha made up of Met772, Pro778, Ile800, Tyr836, Ile848, Val850, Val851, Met922, Phe930 and Ile932 accommodates the flat 2-tert-butyl-4"-methyl-4,5"-bithiazol moiety of A-66S, and the NH of Val851 forms a hydrogen with the nitrogen atom embedded in the aminothiazole ring of A-66S.	Hydrogen	253-261	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	44-53
24059317-5	2014	Hydrophobic interactions and hydrogen bonds both play an equally important role in the correct positioning of Cisplatin within the "acyl pocket" as well as "catalytic site" of AChE to permit docking.	Hydrogen	29-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	176-180
24555410-7	2014	The results suggested that backbone hydrogen bond formation, not only the overall hydrophobicity of IFABP, may play crucial roles in the early collapse.	Hydrogen	36-44	fatty acid binding protein 2	Homo sapiens	100-105
24412302-8	2014	Post-docking intramolecular hydrogen bonding analysis shows water molecule mediated hydrogen bonding for N-terminal maltase glucoamylase and N-terminal sucrase isomaltase.	Hydrogen	28-36	maltase-glucoamylase 2	Rattus norvegicus	116-136
24412302-8	2014	Post-docking intramolecular hydrogen bonding analysis shows water molecule mediated hydrogen bonding for N-terminal maltase glucoamylase and N-terminal sucrase isomaltase.	Hydrogen	84-92	maltase-glucoamylase 2	Rattus norvegicus	116-136
24594779-6	2014	GR expression (GRtotal, 1B, 1C, 1F and 1H) was measured by quantitative RT-PCR.	Hydrogen	39-41	nuclear receptor subfamily 3 group C member 1	Homo sapiens	0-2
24607902-8	2014	Taken together, our results suggest that hydrogen bonding is a major determinant in the interaction of Doa1/PFU with Hse1/SH3.	Hydrogen	41-49	heparanase	Homo sapiens	117-121
24613836-4	2014	The structure reveals that the PDZ1-LPA2 binding specificity is achieved by numerous hydrogen bonds and hydrophobic contacts with the last four LPA2 residues contributing to specific interactions.	Hydrogen	85-93	lysophosphatidic acid receptor 2	Homo sapiens	36-40
24589018-7	2014	Under pH 8.5, 0.07, 0.22 and 0.84 ppm hydrogen exhibited a high correlation with inhibitory effects showed by erosion area, MPO activity and MDA content in the stomach.	Hydrogen	38-46	myeloperoxidase	Homo sapiens	124-127
23820823-0	2014	Batch anaerobic co-digestion of cow manure and waste milk in two-stage process for hydrogen and methane productions.	Hydrogen	83-91	Weaning weight-maternal milk	Bos taurus	53-57
24059317-7	2014	During "Cisplatin-CAS site of AChE enzyme" interaction, it was found that out of the three amino acids constituting the catalytic triad (S203, H447 and E334), two amino acid residues namely S203 and H447 interact with Cisplatin by hydrogen bonding and hydrophobic interaction, respectively.	Hydrogen	231-239	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-34
23934681-5	2014	Docking study showed OA bound to ligand-binding domain of PPARgamma via forming hydrogen bonds with Arg288 and Leu340 sites.	Hydrogen	80-88	peroxisome proliferator activated receptor gamma	Homo sapiens	58-67
24491228-5	2014	Based on our experiments with purified enzyme, the requirements for CYP7B1 hydroxylation of steroid molecules are as follows: C5 hydrogen in the alpha-configuration (or double bond at C5), a polar group at C17, a hydroxyl group at C3, and the absence of the hydroxyl group at C20-C24 in the C27-sterol side chain.	Hydrogen	129-137	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	68-74
24138399-8	2014	In addition, as these compounds showed better binding than PMA, more interaction with PKC residues (hydrogen bonding and hydrophobic), and the top five hit molecules was potent enough to abolish carcinogenic effects of PMA.	Hydrogen	100-108	protein kinase C alpha	Homo sapiens	86-89
24507131-7	2014	The decomposition of the binding free energy indicated that the hydrogen bonds between the residues Glu353, Gly521 and ligands were crucial for anchoring the ligands into the active site of ERalpha and stabilizing their conformations.	Hydrogen	64-72	estrogen receptor 1	Homo sapiens	190-197
24297699-6	2014	Treatment of ob/ob mice with the UII receptor antagonist SB657510 significantly improved glucose levels, blood pressure, hyperlipidemia, expression of myocardial SERCA2a, intracellular Na(+) and Ca(2+) and cardiac function in association with a decrease in weight gain, and mammalian target of rapamycin (mTOR) and sodium/hydrogen exchanger 1 (NHE-1) protein expression compared with vehicle (P&lt;0.05).	Hydrogen	322-330	urotensin 2	Mus musculus	33-36
24398235-5	2014	In the present study, we determined the overall secondary structure of CN in the presence or absence of Ca(2+)/CaM using FT-IR, and the Ca(2+)/CaM-induced structural dynamics and conformational changes were monitored by hydrogen-deuterium exchange experiments.	Hydrogen	220-228	calmodulin 3	Homo sapiens	143-146
24506162-4	2014	The CO2 diffusion coefficients obtained in pure water and water/ethanol mixtures composed of TIP5P water molecules were always found to exceed the coefficients obtained in mixtures composed of SPC/E water molecules, a trend that was attributed to a larger propensity of SPC/E water molecules to form hydrogen bonds.	Hydrogen	300-308	proline rich protein gene cluster	Homo sapiens	270-273
24389507-9	2014	Compared to the control group, the CCl4 group showed significantly increased circulating levels of both sTNF-R1 (797+-121pg/ml) and sTNF-R2 (5696+-626 pg/ml) 1h after CCl4 administration.	Hydrogen	158-160	C-C motif chemokine ligand 4	Rattus norvegicus	35-39
24402189-1	2014	Efficient photocatalytic hydrogen evolution is obtained from 1 M phosphate buffer at pH 7 in the presence of a Ru(bpy)3(2+) sensitizer, an ascorbic acid sacrificial donor, and a water-soluble Co(II) porphyrin catalyst.	Hydrogen	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-198
25007586-4	2014	All 12 compounds could bind to the same cavity of HER-2 kinase domain by high affinity (MolDock Score &lt; -105 kJ/mol for anthocyanidins, &lt; -130 kJ/mol for anthocyanidins-glc), where hydrophobic force and hydrogen bond played key roles.	Hydrogen	209-217	erb-b2 receptor tyrosine kinase 2	Homo sapiens	50-55
24375409-4	2014	Our study reveals that residues of the hPP and the hY4R form a complex network consisting of ionic interactions, hydrophobic interactions, and hydrogen binding.	Hydrogen	143-151	familial progressive hyperpigmentation 1	Homo sapiens	39-42
24375409-7	2014	Asn(7.32) is affected by modifications on position Arg(33) of hPP, suggesting a hydrogen bond between these two residues.	Hydrogen	80-88	familial progressive hyperpigmentation 1	Homo sapiens	62-65
24361737-12	2014	In the mouse striatum, QUIN per se exerted an induction of Nrf2 factor only at 1h of incubation, and a concentration-response effect on lipid peroxidation after 3h of incubation.	Hydrogen	79-81	nuclear factor, erythroid derived 2, like 2	Mus musculus	59-63
24471583-0	2014	Electronic structure of H2S, SF2, and HSF and implications for hydrogen-substituted hypervalent sulfur fluorides.	Hydrogen	63-71	interleukin 6	Homo sapiens	38-41
24506162-6	2014	This difference was deemed to rely on the larger propensity of SPC/E water molecules to maintain the hydrogen-bonded network between water molecules and form new hydrogen bonds with ethanol, although statistical issues cannot be completely excluded.	Hydrogen	101-109	proline rich protein gene cluster	Homo sapiens	63-66
24506162-6	2014	This difference was deemed to rely on the larger propensity of SPC/E water molecules to maintain the hydrogen-bonded network between water molecules and form new hydrogen bonds with ethanol, although statistical issues cannot be completely excluded.	Hydrogen	162-170	proline rich protein gene cluster	Homo sapiens	63-66
24860196-6	2014	Thus, for the H2/CO2 gas pair, whereas PIM-1 favors CO2, amine-PIM-1 shows permselectivity toward H2, breaking the Robeson 2008 upper bound.	Hydrogen	98-100	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	63-68
24753636-2	2014	As investigated by 1H NMR, the receptor forms both 1:1 and 1:2 complex yielding the binding constants of 2.32(3) (in log beta1 ) and 4.39(4) (in log beta2 ), respectively; where quinoline groups are protonated by the fluoride-induced proton transfer from the solution to the host molecule.	Hydrogen	19-21	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	121-126
25076515-4	2014	The results showed that As(V) reduction was a biochemical process while both acclimated sludge and hydrogen were essential.	Hydrogen	99-107	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	24-29
26276595-3	2014	In addition to this, CCl has improved surface mobility (~30.0 kcal/mol barrier, versus 35 kcal/mol for CH2, along the C-C dimer chain direction), and hydrogen abstraction from the surface is also favored via atomic Cl in the vapor phase.	Hydrogen	150-158	crystallin gamma E, pseudogene	Homo sapiens	21-24
24339424-5	2014	The results suggest that the D ring is essential to potency, however it can be modified, for example to C18 hydrogen bond acceptor and/or donor furan ring analogues, without complete loss of cytotoxic activity.	Hydrogen	108-116	Bardet-Biedl syndrome 9	Homo sapiens	104-107
24467431-5	2014	The active channels were functionally competent with demonstrated modulatory response to H2 S and transforming growth factor (TGF)-beta1 whereby H2S significantly inhibited the stimulatory effect of TGF-beta1 on current density of both BKCa and IK(ir).	Hydrogen	89-91	transforming growth factor beta 1	Homo sapiens	199-208
24346623-0	2014	Weak C-H   N and C-H   F hydrogen bonds and internal rotation in pyridine-CH3F.	Hydrogen	25-33	nuclear receptor subfamily 4 group A member 3	Homo sapiens	5-20
24346623-2	2014	Two weak C-H   N and C-H   F hydrogen bonds link the two subunits of the complex.	Hydrogen	29-37	nuclear receptor subfamily 4 group A member 3	Homo sapiens	9-24
24411123-7	2014	Compounds 1b-1f, 1h effectively inhibited the in vitro kinase activity of EGFR and HER2 with similar efficacy as erlotinib and gefitinib.	Hydrogen	17-19	epidermal growth factor receptor	Homo sapiens	74-78
24411123-7	2014	Compounds 1b-1f, 1h effectively inhibited the in vitro kinase activity of EGFR and HER2 with similar efficacy as erlotinib and gefitinib.	Hydrogen	17-19	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-87
24581800-6	2014	The results revealed that beta1-beta3 is more likely to form a di-polymer than beta1-beta1 based on molecular interaction analysis, including potential energy analysis, Van der Waals (VDW) energy analysis and electrostatic energy analysis, and in addition, consideration of the hydrogen bonds and hydrophobic contacts that are involved.	Hydrogen	278-286	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	26-31
24581800-6	2014	The results revealed that beta1-beta3 is more likely to form a di-polymer than beta1-beta1 based on molecular interaction analysis, including potential energy analysis, Van der Waals (VDW) energy analysis and electrostatic energy analysis, and in addition, consideration of the hydrogen bonds and hydrophobic contacts that are involved.	Hydrogen	278-286	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	79-84
24581800-6	2014	The results revealed that beta1-beta3 is more likely to form a di-polymer than beta1-beta1 based on molecular interaction analysis, including potential energy analysis, Van der Waals (VDW) energy analysis and electrostatic energy analysis, and in addition, consideration of the hydrogen bonds and hydrophobic contacts that are involved.	Hydrogen	278-286	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	79-84
24689288-5	2014	The chrysin-serum albumin complex was stabilized by hydrophobic force and hydrogen bonding and the reaction was a spontaneous process.	Hydrogen	74-82	albumin	Homo sapiens	12-25
23801196-0	2014	Supramolecular photocyclodimerization of 2-hydroxyanthracene with a chiral hydrogen-bonding template, cyclodextrin and serum albumin.	Hydrogen	75-83	albumin	Homo sapiens	119-132
24401421-5	2014	Analysis of these parameters for the system gives evidence that HSA molecules are very likely to be attached to AuNPs surface predominantly as a flat monolayer to form a stable AuNPs-HSA conjugate with a core-shell structure, and the binding process takes place mainly through electrostatic and hydrogen-bond interactions between the positively amino acid residues of HSA and the negatively carboxyl group of citrate on AuNPs surface.	Hydrogen	295-303	albumin	Homo sapiens	64-67
24593544-1	2014	Results from initial stage of modeling of the SPIDER source of negative hydrogen/deuterium ions currently under development in Consorzio RFX (Padova) regarding ITER are presented.	Hydrogen	72-80	regulatory factor X1	Homo sapiens	137-140
24299758-2	2014	The results showed that CMKGM and SPI are highly compatible in blended film formation, and that Maillard reactions and hydrogen bonds interactions between CMKGM and SPI occurred.	Hydrogen	119-127	chromogranin A	Homo sapiens	165-168
24153436-0	2014	Fac and mer isomers of Ru(II) tris(pyrazolyl-pyridine) complexes as models for the vertices of coordination cages: structural characterisation and hydrogen-bonding characteristics.	Hydrogen	147-155	FA complementation group C	Homo sapiens	0-3
24061635-2	2014	Our experiment on three-body dissociation of state selected H3 and D3 molecules into ground-state hydrogen atoms strongly suggests the existence of such a close relationship as it is also predicted by theory in the form of the imaging theorem.	Hydrogen	98-106	H3 clustered histone 14	Homo sapiens	60-69
24161873-4	2014	Vander Waals force and hydrogen bond played major roles in the interaction of HPAE with BSA.	Hydrogen	23-31	albumin	Homo sapiens	88-91
24288296-6	2014	We further show that the excess uptake of hydrogen on MgPc and CaPc cages at 298 K and 100 bar (1 bar=0.1 MPa) is about 3.49 and 4.74 wt%, respectively.	Hydrogen	42-50	leucine rich repeat containing 26	Homo sapiens	63-67
24153436-5	2014	In the fac isomers the convergent group of pendant -CH2R or -CH3 protons defines a hydrogen-bond donor pocket; in the mer isomer these protons do not converge and any hydrogen-bonding involving these protons is expected to be weaker.	Hydrogen	83-91	FA complementation group C	Homo sapiens	7-10
24153436-8	2014	We conclude that (i) the presence of fac tris-chelate sites in the cage to act as hydrogen-bond donors, and (ii) exclusion of counter-ions from the central cavity leaving these hydrogen-bonding sites free to interact with guests, are both important design criteria for future coordination cage hosts.	Hydrogen	82-90	FA complementation group C	Homo sapiens	37-40
24404164-11	2014	In silicio docking studies support the view that EGCG binds directly to the active site of 11beta-HSD1 by forming a hydrogen bond with Lys187 of the catalytic triade.	Hydrogen	116-124	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	91-102
24283196-5	2014	Furthermore, the aminoalkyl group in the side chain of EPO forms a hydrophilic interaction, which can be either electrostatic or hydrogen bonding, with the carboxyl group of MFA.	Hydrogen	129-137	erythropoietin	Homo sapiens	55-58
24721310-0	2014	[Suppression of abdominal aortic aneurysm by hydrogen through chemokine-like factor1].	Hydrogen	45-53	chemokine-like factor	Rattus norvegicus	62-84
24721310-12	2014	CONCLUSIONS: Hydrogen which may contribute to reduce rCklf1 expression prevents infiltration of inflammation and expression of MMP2 thus decreasing destruction and degradation of elastic fibers, therefore ameliorates development of AAA.	Hydrogen	13-21	chemokine-like factor	Rattus norvegicus	53-59
24291708-0	2014	1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase.	Hydrogen	0-2	heparanase	Homo sapiens	44-54
25477959-6	2014	Our data revealed that, Abeta42 specifically recognizes CRD1 and CRD2 domains of the receptor and formed a "cap" like structure at the N-terminal of receptor which is stabilized by a network of hydrogen bonds.	Hydrogen	194-202	CORD1	Homo sapiens	56-60
24369116-4	2014	Our results show considerable differences in H43R compared to WT and W32F mutated SOD1, such as increasing distances between the critical residues results in open conformation at the active site, strong fluctuations in the important loops (Zinc and electrostatic loops) and weakening of important hydrogen bonds especially between N (His 43/Arg 43) and carbonyl oxygen (His 120) in agreement with the experimental report.	Hydrogen	297-305	superoxide dismutase 1	Homo sapiens	82-86
24315190-8	2014	But, the presence of this aliphatic hydroxyl is not required in all compounds, since mono-hydroxyl (phenolic) compounds bind ERalpha with high affinity, via hydroxyl hydrogen bonding interactions with the ERalpha Arg394/Glu353/water triad, and van der Waals interactions with the rest of the molecule.	Hydrogen	166-174	estrogen receptor 1	Homo sapiens	125-132
24675911-6	2014	RESULTS: During 1h of exercise recovery, there was a reduction in SBP (3-6 mmHg) and DBP (2-5 mmHg) in relation to pre-session rest (p&lt;0.01), while this reduction was not observed in the control session.	Hydrogen	16-18	D-box binding PAR bZIP transcription factor	Homo sapiens	71-88
25898721-0	2014	[Solid state isotope hydrogen exchange for deuterium and tritium in human gene-engineered insulin].	Hydrogen	21-29	insulin	Homo sapiens	90-97
25898721-2	2014	The reaction of human gene-engineered insulin with deuterium and tritium was conducted at 120-140  C to produce insulin samples containing 2-6 hydrogen isotope atoms.	Hydrogen	143-151	insulin	Homo sapiens	38-45
25898721-2	2014	The reaction of human gene-engineered insulin with deuterium and tritium was conducted at 120-140  C to produce insulin samples containing 2-6 hydrogen isotope atoms.	Hydrogen	143-151	insulin	Homo sapiens	112-119
24603403-9	2014	Since downregulation of claudin-4 increases paracellular permeability to cations, e.g. hydrogen ions, NSE is more vulnerable to attack and damage by acidic and weakly acidic refluxates--a phenomenon that may contribute in part to the reemergence of BE.	Hydrogen	87-95	claudin 4	Homo sapiens	24-33
24496246-10	2014	Transcript levels of IP3 receptor IP3R2 and of IP3R2 regulating transcription factor ETS1 were significantly higher in akt2(+/+) than in akt2(-/-) DCs prior to maturation and were upregulated by LPS stimulation (1h) in akt2(+/+) and to a lower extent in akt2(-/-) DCs.	Hydrogen	212-214	inositol 1,4,5-triphosphate receptor 2	Mus musculus	47-52
24273094-5	2014	We considered that the large conformational change at Trp741 of the androgen receptor (AR) and the hydrogen bond between 1 d and helix 12 of the AR could maintain the structure of the AR in its agonist form; indeed, 1 d displays strong AR agonistic activity.	Hydrogen	99-107	androgen receptor	Homo sapiens	145-147
24273094-5	2014	We considered that the large conformational change at Trp741 of the androgen receptor (AR) and the hydrogen bond between 1 d and helix 12 of the AR could maintain the structure of the AR in its agonist form; indeed, 1 d displays strong AR agonistic activity.	Hydrogen	99-107	androgen receptor	Homo sapiens	145-147
24273094-5	2014	We considered that the large conformational change at Trp741 of the androgen receptor (AR) and the hydrogen bond between 1 d and helix 12 of the AR could maintain the structure of the AR in its agonist form; indeed, 1 d displays strong AR agonistic activity.	Hydrogen	99-107	androgen receptor	Homo sapiens	145-147
24284025-6	2014	CONCLUSIONS: Elevated hs-cTnT levels provide strong and independent prognostic information in older patients with chronic ischemic HF.	Hydrogen	22-24	troponin T2, cardiac type	Homo sapiens	25-29
24392463-11	2014	Correlation between serum TNF-a and IL6 levels with healthy donors were statistically significant in 1h (0.004), 2h (0.001), 24h (0.001) and 48h (0.001 and 0.001) postoperatively, respectively.	Hydrogen	101-103	tumor necrosis factor	Homo sapiens	26-31
24269511-4	2014	SAR and docking studies allowed the identification of pharmacophoric groups for both kinases and demonstrated the importance of a hydrogen bond donor at the para position of the aniline moiety for interaction with conserved Glu and Asp amino acids in EGFR and VEGFR-2 binding sites.	Hydrogen	130-138	epidermal growth factor receptor	Homo sapiens	251-255
24292339-3	2014	The binding model suggests one or two hydrogen bonding interactions between pyrrole hydrazones and InhA enzyme.	Hydrogen	38-46	inhibin subunit alpha	Homo sapiens	99-103
24392463-11	2014	Correlation between serum TNF-a and IL6 levels with healthy donors were statistically significant in 1h (0.004), 2h (0.001), 24h (0.001) and 48h (0.001 and 0.001) postoperatively, respectively.	Hydrogen	101-103	interleukin 6	Homo sapiens	36-39
23689033-9	2014	Normalized moxifloxacin QTca responses (Veh Delta%/muM) were derived for 1h centered on the moxifloxacin Tmax.	Hydrogen	73-75	latexin	Homo sapiens	51-54
25383217-10	2014	Docking and molecular dynamics (MD) suggested that the inhibitor made hydrogen bond contacts with TIM catalytic residues.	Hydrogen	70-78	triosephosphate isomerase 1	Homo sapiens	98-101
24117897-7	2014	Treatment with H2 S abated MCD-diet-induced oxidative stress through reducing cytochrome p4502E1 expression, enhancing heme oxygenase-1 expression, and suppressing mitochondrial reactive oxygen species formation, and suppressed MCD-diet-induced inflammation through suppressing activated nuclear factor kappaB signaling and reducing interleukin-6 and tumor necrosis factor alpha expressions.	Hydrogen	15-17	interleukin 6	Rattus norvegicus	333-378
24028527-8	2014	At 800 K, the Bcl-2 core is destabilized suggesting a possible mechanism for protein unfolding, where the alpha helices 1 and 6 were the most stable, and a reduction in the number of hydrogen bonds initially occurs.	Hydrogen	183-191	BCL2 apoptosis regulator	Homo sapiens	14-19
24000822-8	2014	The unusual orientation of Abeta peptide residues affects hydrophobic interactions and hydrogen bonding network between hECE-1 and Abeta peptide.	Hydrogen	87-95	amyloid beta precursor protein	Homo sapiens	120-136
24862279-6	2014	In addition, hypoxia induces (1) the HIF-1-dependent expression of BCL2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) and BNIP3-like (BNIP3L), which trigger mitochondrial autophagy, thereby decreasing the oxidative metabolism of both fatty acids and glucose, and (2) the expression of the sodium-hydrogen exchanger NHE1, which maintains an alkaline intracellular pH.	Hydrogen	302-310	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-42
24862279-6	2014	In addition, hypoxia induces (1) the HIF-1-dependent expression of BCL2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) and BNIP3-like (BNIP3L), which trigger mitochondrial autophagy, thereby decreasing the oxidative metabolism of both fatty acids and glucose, and (2) the expression of the sodium-hydrogen exchanger NHE1, which maintains an alkaline intracellular pH.	Hydrogen	302-310	BCL2 interacting protein 3	Homo sapiens	67-115
24366091-3	2013	It was revealed that the FN-III10 is the most important module among FN-III7-10 in promoting fibronectin binding to HAP by optimizing the interaction energy; the arginine residues were observed to directly interact with the hydroxyl group of HAP through electrostatic forces and hydrogen bonding.	Hydrogen	279-287	fibronectin 1	Homo sapiens	93-104
25621306-1	2014	Three active-site components in rhodopsin play a key role in the stability and function of the protein: 1) the counter-ion residues which stabilize the protonated Schiff base, 2) water molecules, and 3) the hydrogen-bonding network.	Hydrogen	207-215	rhodopsin	Homo sapiens	32-41
25621306-2	2014	The ionizable residue Glu-181, which is involved in an extended hydrogen-bonding network with Ser-186, Tyr-268, Tyr-192, and key water molecules within the active site of rhodopsin, has been shown to be involved in a complex counter-ion switch mechanism with Glu-113 during the photobleaching sequence of the protein.	Hydrogen	64-72	rhodopsin	Homo sapiens	171-180
25621306-8	2014	We conclude that the substitution of Glu-181 with Gln-181 results in a significant perturbation of the hydrogen-bonding network within the active site of rhodopsin.	Hydrogen	103-111	rhodopsin	Homo sapiens	154-163
24091191-9	2014	For the BSA-humic acid system; electrostatic, hydrophobic and hydrogen bonding were the dominant types of interactions predicted, whilst divalent ion-mediated bonding was not identified in the simulations, which supported the LC-results.	Hydrogen	62-70	albumin	Homo sapiens	8-11
24275002-9	2014	However, the decrease of serum-S100B 1h after glucose ingestion correlated inversely with the respective changes of serum-insulin (r = -0.484, P=0.049) and serum-C-peptide (r = -0.570, P = 0.017).	Hydrogen	37-39	S100 calcium binding protein B	Homo sapiens	31-36
24275002-9	2014	However, the decrease of serum-S100B 1h after glucose ingestion correlated inversely with the respective changes of serum-insulin (r = -0.484, P=0.049) and serum-C-peptide (r = -0.570, P = 0.017).	Hydrogen	37-39	insulin	Homo sapiens	122-129
24358204-4	2013	This was confirmed by molecular modeling showing that Tyr145Asp substitution results in changed electrostatic potential of the CYP51 protein surface and lengthened distance to the heme which prevents hydrogen bonding.	Hydrogen	200-208	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	127-132
27493555-5	2013	The water O-H stretching vibrations of pHR(Cl(-)) and pHR(Br(-)) at 3617 and 3630 cm(-1), respectively, are confirmed by light-induced difference FTIR spectra in isotope water (H2 (18)O) at 77 K. The observed water molecule presumably binds to the active center of pHR, and alter its hydrogen bond during the Cl(-) pumping photocycle.	Hydrogen	284-292	MYC binding protein 2	Homo sapiens	39-42
27493555-5	2013	The water O-H stretching vibrations of pHR(Cl(-)) and pHR(Br(-)) at 3617 and 3630 cm(-1), respectively, are confirmed by light-induced difference FTIR spectra in isotope water (H2 (18)O) at 77 K. The observed water molecule presumably binds to the active center of pHR, and alter its hydrogen bond during the Cl(-) pumping photocycle.	Hydrogen	284-292	MYC binding protein 2	Homo sapiens	54-57
27493555-5	2013	The water O-H stretching vibrations of pHR(Cl(-)) and pHR(Br(-)) at 3617 and 3630 cm(-1), respectively, are confirmed by light-induced difference FTIR spectra in isotope water (H2 (18)O) at 77 K. The observed water molecule presumably binds to the active center of pHR, and alter its hydrogen bond during the Cl(-) pumping photocycle.	Hydrogen	284-292	MYC binding protein 2	Homo sapiens	54-57
24376700-9	2013	The phosphorylation of EGFR at Tyr1068 and Nrf2 up-regulation expression in the rat lungs challenged by CS exposure were also abrogated by hydrogen-rich saline.	Hydrogen	139-147	NFE2 like bZIP transcription factor 2	Rattus norvegicus	43-47
24266650-1	2013	A Co(II) anilinosalen catalyst containing proton relays in the first coordination sphere has been synthesized that catalyzes the electrochemical production of hydrogen from acid in dichloromethane and acetonitrile solutions.	Hydrogen	159-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	2-8
24337290-2	2013	From spectra obtained with the Herschel Space Observatory, we report the detection of emission in the 617.5- and 1234.6-gigahertz J = 1-0 and 2-1 rotational lines of (36)ArH(+) at several positions in the Crab Nebula, a supernova remnant known to contain both molecular hydrogen and regions of enhanced ionized argon emission.	Hydrogen	270-278	low density lipoprotein receptor adaptor protein 1	Homo sapiens	170-173
24099549-0	2013	The hydrogen-peroxide-induced radical behaviour in human cytochrome c-phospholipid complexes: implications for the enhanced pro-apoptotic activity of the G41S mutant.	Hydrogen	4-12	cytochrome c, somatic	Homo sapiens	57-69
24410493-4	2014	Hydrogen bond interactions indicated that OBP is responsible for pheromone release through saliva.	Hydrogen	0-8	odorant-binding protein	Bos taurus	42-45
24688730-3	2013	Using molecular dynamics simulations, MM/GBSA free energy calculations, hydrogen bond analysis, water characterization and umbrella sampling, we provide a complete atomistic picture of the binding between inlA and Ecad.	Hydrogen	72-80	cadherin 1	Mus musculus	214-218
24377105-6	2013	Among the five different chemistries, the HSS C18 SB phase displays a rather unusual behavior in regards of classical C18 phases, as it displays significant hydrogen-bonding interactions.	Hydrogen	157-165	Bardet-Biedl syndrome 9	Homo sapiens	46-49
24377105-6	2013	Among the five different chemistries, the HSS C18 SB phase displays a rather unusual behavior in regards of classical C18 phases, as it displays significant hydrogen-bonding interactions.	Hydrogen	157-165	Bardet-Biedl syndrome 9	Homo sapiens	118-121
24017972-6	2013	Upregulation of Nrf2 by sulforaphane treatment prior to transient MCAo (1h) was associated with increased HO-1 expression in perivascular astrocytes in peri-infarct regions and cerebral endothelium in the infarct core.	Hydrogen	72-74	NFE2 like bZIP transcription factor 2	Rattus norvegicus	16-20
24075938-5	2013	Docking studies suggested that NSAIDs forming hydrogen bonds with Ser530, Arg120, Tyr385 and other amino acids of the COX-1 hydrophobic channel interfere with antiplatelet activity of aspirin while non interfering NSAIDs do not form relevant hydrogen bond interactions within the aspirin binding site.	Hydrogen	46-54	prostaglandin-endoperoxide synthase 1	Homo sapiens	118-123
24075938-5	2013	Docking studies suggested that NSAIDs forming hydrogen bonds with Ser530, Arg120, Tyr385 and other amino acids of the COX-1 hydrophobic channel interfere with antiplatelet activity of aspirin while non interfering NSAIDs do not form relevant hydrogen bond interactions within the aspirin binding site.	Hydrogen	242-250	prostaglandin-endoperoxide synthase 1	Homo sapiens	118-123
24124100-0	2013	Noble-metal-free NiS/C3 N4 for efficient photocatalytic hydrogen evolution from water.	Hydrogen	56-64	solute carrier family 5 member 5	Homo sapiens	17-20
24124100-3	2013	The optimal loading of 1.1 wt % NiS on C3 N4 as a cocatalyst can enhance the H2 production by about 250 times compared with the native C3 N4 .	Hydrogen	77-79	solute carrier family 5 member 5	Homo sapiens	32-35
24195792-5	2013	Based on a docking study, we propose a model of eriodictyol and JNK binding, in which eriodictyol forms 3 hydrogen bonds with the side chains of Lys55, Met111, and Asp169 in JNK, and in which the hydroxyl groups of the B ring play key roles in binding interactions with JNK.	Hydrogen	106-114	mitogen-activated protein kinase 8	Homo sapiens	64-67
23954468-0	2013	Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression.	Hydrogen	79-87	NFE2 like bZIP transcription factor 2	Rattus norvegicus	102-106
24014151-2	2013	The method was named atmospheric pressure photo ionization hydrogen/deuterium exchange mass spectrometry (APPI HDX MS).	Hydrogen	59-67	amyloid beta precursor protein	Homo sapiens	106-110
23786587-8	2013	Heavy ion radiation-induced Caspase 3 activation was also inhibited by H(2) treatment.	Hydrogen	71-75	caspase 3	Homo sapiens	28-37
24012827-6	2013	RESULTS: In crystallized samples, acidified samples with 1h incubation had significantly higher Ca/Cr, P/Cr, and Mg/Cr than did untreated samples with mean differences of 0.04, 0.03, and 0.01 mg/mg, respectively (P&lt;0.001).	Hydrogen	57-59	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	103-118
24253321-11	2013	The keys residues which contribute to the binding of p53 to DNA by forming crucial hydrogen bonds have also been discussed in detail.	Hydrogen	83-91	tumor protein p53	Homo sapiens	53-56
24248473-5	2013	While overall structure of TRPV3-ARD is similar to ARDs from other members of TRPV subfamily; it, however, features a noticeable finger 3 loop that bends over and is stabilized by a network of hydrogen bonds and hydrophobic packing, instead of being flexible as seen in known TRPV-ARD structures.	Hydrogen	193-201	transient receptor potential cation channel subfamily V member 3	Homo sapiens	27-32
24144240-3	2013	Docking of ligands 2 (MOR selective) and 10 (MOR/KOR dual selective) to the three opioid receptor crystal structures revealed a nonconserved-residue-facilitated hydrogen-bonding network that could be responsible for their distinctive selectivity profiles.	Hydrogen	161-169	opioid receptor, mu 1	Mus musculus	22-25
24144240-3	2013	Docking of ligands 2 (MOR selective) and 10 (MOR/KOR dual selective) to the three opioid receptor crystal structures revealed a nonconserved-residue-facilitated hydrogen-bonding network that could be responsible for their distinctive selectivity profiles.	Hydrogen	161-169	opioid receptor, mu 1	Mus musculus	45-48
23966063-0	2013	Carbon-coated Li3 N nanofibers for advanced hydrogen storage.	Hydrogen	44-52	cytochrome P450 family 4 subfamily F member 22	Homo sapiens	14-17
23998955-6	2013	The molecular modeling simulation explained the binding of MH to the human serum albumin (HSA) by hydrogen bonds during the in vitro release process.	Hydrogen	98-106	albumin	Homo sapiens	75-88
24423914-10	2013	The results of 24 h fluorescence indicated that, compared with group A, VE-cadherin was incomplete in cell-cell connections in group C.However it was complete and well-distributed in group D versus group C. CONCLUSION: Hydrogen-rich medium may reduce the LPS-induced release of adhesion molecules, lessen monocytic adhesion to HUVEC and regulate the expression of VE-cadherin to protect vascular permeability.	Hydrogen	219-227	cadherin 5	Homo sapiens	72-83
24423914-10	2013	The results of 24 h fluorescence indicated that, compared with group A, VE-cadherin was incomplete in cell-cell connections in group C.However it was complete and well-distributed in group D versus group C. CONCLUSION: Hydrogen-rich medium may reduce the LPS-induced release of adhesion molecules, lessen monocytic adhesion to HUVEC and regulate the expression of VE-cadherin to protect vascular permeability.	Hydrogen	219-227	cadherin 5	Homo sapiens	364-375
24164352-6	2013	It is observed that in wild-type cAOS the active site Thr66 residue consistently forms a strong hydrogen-bonding interaction with H2O2 (catalase substrate) and, importantly, with the aid of His67 helps to pull H2O2 away from the heme Fe center.	Hydrogen	96-104	catalase	Homo sapiens	136-144
24117141-7	2013	The structural characteristics for an (iso)flavonoid to activate hTAS2R14 (or hTAS2R39) were determined by 3D-pharmacophore models to be composed of two (or three) hydrogen bond donor sites, one hydrogen bond acceptor site, and two aromatic ring structures, of which one had to be hydrophobic.	Hydrogen	164-172	taste 2 receptor member 39	Homo sapiens	78-86
24100137-2	2013	Crystal structures reported here reveal a surprising Trp112 native conformation stabilized by a specific Gln114-centered hydrogen bond network in the AKR1B10 holoenzyme, and suggest that AKR1B1 inhibitors could retain their binding affinities toward AKR1B10 by inducing Trp112 flip to result in an "AKR1B1-like" active site in AKR1B10, while selective AKR1B10 inhibitors can take advantage of the broader active site of AKR1B10 provided by the native Trp112 side-chain orientation.	Hydrogen	121-129	aldo-keto reductase family 1 member B	Homo sapiens	150-156
24100137-2	2013	Crystal structures reported here reveal a surprising Trp112 native conformation stabilized by a specific Gln114-centered hydrogen bond network in the AKR1B10 holoenzyme, and suggest that AKR1B1 inhibitors could retain their binding affinities toward AKR1B10 by inducing Trp112 flip to result in an "AKR1B1-like" active site in AKR1B10, while selective AKR1B10 inhibitors can take advantage of the broader active site of AKR1B10 provided by the native Trp112 side-chain orientation.	Hydrogen	121-129	aldo-keto reductase family 1 member B	Homo sapiens	187-193
24233717-1	2013	Cytochrome P450 enzymes activate oxygen at heme iron centers to oxidize relatively inert substrate carbon-hydrogen bonds.	Hydrogen	106-114	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
24320247-1	2013	The ejection of triatomic hydrogen molecular ions HD2(+) and D3(+) from CD3OH(2+) is investigated by first-principle molecular dynamics simulation.	Hydrogen	26-34	histone deacetylase 2	Homo sapiens	50-53
24085300-7	2013	Based on the crystal structures of the p25 (p35 C-terminal region including AD)-Cdk5 complex, we simulated the three-dimensional structure of the p39 AD-Cdk5 complex and found differences in the hydrogen bond network between Cdk5 and its activators.	Hydrogen	195-203	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	146-149
24085300-8	2013	Three amino acids of p35, Asp-259, Asn-266, and Ser-270, which are involved in hydrogen bond formation with Cdk5, are changed to Gln, Gln, and Pro in p39.	Hydrogen	79-87	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	150-153
24085300-9	2013	Because these three amino acids in p39 do not participate in hydrogen bond formation, we predicted that the number of hydrogen bonds between p39 and Cdk5 was reduced compared with p35 and Cdk5.	Hydrogen	118-126	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	35-38
24085300-9	2013	Because these three amino acids in p39 do not participate in hydrogen bond formation, we predicted that the number of hydrogen bonds between p39 and Cdk5 was reduced compared with p35 and Cdk5.	Hydrogen	118-126	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	141-144
28788378-0	2013	Hydrogen Bonding-Mediated Microphase Separation during the Formation of Mesoporous Novolac-Type Phenolic Resin Templated by the Triblock Copolymer, PEO-b-PPO-b-PEO.	Hydrogen	0-8	protoporphyrinogen oxidase	Homo sapiens	154-157
24140435-8	2013	Inhibitory effects of CGRP were also observed when briefly exposing RMA and HCMA to CGRP 1h before the addition of ET-1.	Hydrogen	89-91	calcitonin related polypeptide alpha	Homo sapiens	22-26
24140435-10	2013	In conclusion, our data imply that CGRP, like ET-1, causes long-lasting effects that remain apparent up to 1h after its removal from the organ bath.	Hydrogen	107-109	calcitonin related polypeptide alpha	Homo sapiens	35-39
24140435-10	2013	In conclusion, our data imply that CGRP, like ET-1, causes long-lasting effects that remain apparent up to 1h after its removal from the organ bath.	Hydrogen	107-109	endothelin 1	Homo sapiens	46-50
24064216-2	2013	Computational models of human P-gp in the apo- and nucleotide-bound conformation show that the adenine group of ATP forms hydrogen bonds with the conserved Asp-164 and Asp-805 in intracellular loops 1 and 3, respectively, which are located at the interface between the nucleotide binding domains and transmembrane domains.	Hydrogen	122-130	ATP binding cassette subfamily B member 1	Homo sapiens	30-34
24071912-6	2013	The reversible hydrogen storage capacity tends to decrease possibly due to the formation of NaF and Na2B12H12.	Hydrogen	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
24105795-2	2013	In this study, DFT calculations were used to investigate their catalytic mechanism, to demonstrate that the initial active state was a Co(I) complex and that H2 was evolved in a heterolytic manner through the protonation of a Co(II)-hydride intermediate.	Hydrogen	158-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
24117141-7	2013	The structural characteristics for an (iso)flavonoid to activate hTAS2R14 (or hTAS2R39) were determined by 3D-pharmacophore models to be composed of two (or three) hydrogen bond donor sites, one hydrogen bond acceptor site, and two aromatic ring structures, of which one had to be hydrophobic.	Hydrogen	195-203	taste 2 receptor member 39	Homo sapiens	78-86
24117141-8	2013	The additional hydrogen bond donor feature for hTAS2R39 ligands indicated the possible presence of another complementary acceptor site in the binding pocket, compared to hTAS2R14.	Hydrogen	15-23	taste 2 receptor member 39	Homo sapiens	47-55
24085537-5	2013	The substituted groups on the pyrrolidine ring of Lig1 also show a strong tendency to mediate protein-ligand interactions through the hydrogen bonds formed between the amino or amide groups of Lig1 and the carboxyl O atoms of Glu234, Glu278, and Asp292 of PKBalpha.	Hydrogen	134-142	AKT serine/threonine kinase 1	Homo sapiens	256-264
24276616-5	2013	In this study, we computationally analyzed the role of this water molecule as a putative hydrogen bond donor/acceptor moiety in the agonist binding site of the three most relevant heteromeric (alpha4beta2, alpha3beta4) and homomeric (alpha7) neuronal nicotinic acetylcholine receptor (nAChR) subtypes.	Hydrogen	89-97	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	285-290
24047682-4	2013	MEC tests with AnMBR permeate (mainly propionate and acetate) and propionate medium confirmed that propionate was fermented to acetate and hydrogen gas, and anode-respiring bacteria (ARB) utilized these fermentation products as substrate.	Hydrogen	139-147	C-C motif chemokine ligand 28	Homo sapiens	0-3
24257230-8	2013	In addition, hydrogen-rich saline also suppressed the expression of p38-mitogen-activated protein kinase (p38MAPK) and brain-derived neurotrophic factor (BDNF) in the spinal cord by 7 days post-chronic constriction injury (p&lt;0.01, p&lt;0.01, respectively), but had no effect on P2X4R (p&gt;0.05), an ATP receptor.	Hydrogen	13-21	purinergic receptor P2X 7	Rattus norvegicus	303-315
23939620-6	2013	Thus, the RNA loading and tight coupling of NTPase activity with RNA translocation in 8 P4 is due to a remarkable C-terminal structure, which wraps right around the outside of the molecule to insert into the central hole where RNA binds to coupled L1 and L2 loops, whereas in 12 P4, a C-terminal residue, serine 282, forms a specific hydrogen bond to the N7 of purines ring to confer purine specificity for the 12 enzyme.	Hydrogen	334-342	L1 cell adhesion molecule	Homo sapiens	248-257
24121341-5	2013	Through these water molecules, the bound ANS molecule forms indirect hydrogen-bond interactions with FABP3.	Hydrogen	69-77	fatty acid binding protein 3	Homo sapiens	101-106
24167618-5	2013	In Postn(+/+) mice, cracks number and surface (CsNb, CsS) increased 1h after fatigue, with a decrease in strength compared to non-fatigued tibia.	Hydrogen	68-70	periostin, osteoblast specific factor	Mus musculus	3-8
24167618-5	2013	In Postn(+/+) mice, cracks number and surface (CsNb, CsS) increased 1h after fatigue, with a decrease in strength compared to non-fatigued tibia.	Hydrogen	68-70	casein beta	Mus musculus	47-51
24454084-1	2013	In the crystal of the title salt, C3H11NOP(+) NO3 (-), dicationic inversion dimers are head-to-tail connected by a pair of strong N-H O hydrogen bonds.	Hydrogen	136-144	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
24144230-8	2013	We also observe that some changes in aromatic ring substituents (for example hydrogen to methoxy) can also reduce hERG binding in vitro.	Hydrogen	77-85	ETS transcription factor ERG	Homo sapiens	114-118
23996395-5	2013	RESULTS: A beta-hydrogen transfer rearrangement, leading to the selective cleavage of the -O-CH2- bonds, and cleavage of the -CH2-CO- bonds, the ester bonds, and the -CH2-CH2- bonds in the diol moiety were observed.	Hydrogen	16-24	amyloid beta precursor protein	Homo sapiens	9-15
23996395-9	2013	CONCLUSIONS: A beta-hydrogen transfer rearrangement has been proposed as the main fragmentation mechanism occurring in PBSu without using the collision gas.	Hydrogen	20-28	amyloid beta precursor protein	Homo sapiens	13-19
24088384-8	2013	Structural predictions, in combination with molecular dynamics simulations suggest that the repeat ensemble forms a beta-solenoid, namely a beta-helical fold with a polar core, stabilized by hydrogen-bonded ladders of polar residues.	Hydrogen	191-199	amyloid beta precursor protein	Homo sapiens	114-120
24116148-6	2013	Compound 1h also reduced secretion of IL-6 and tumor necrosis factor-alpha by LPS-activated J774A.1 murine macrophage cells, primary mice peritoneal macrophages, and JAWSII murine bone marrow-derived dendritic cells and reduced NLRP3 inflammasome-mediated interleukin-1beta (IL-1beta) secretion by LPS + adenosine triphosphate-activated J774A.1 and JAWSII cells.	Hydrogen	9-11	interleukin 6	Mus musculus	38-74
24116148-6	2013	Compound 1h also reduced secretion of IL-6 and tumor necrosis factor-alpha by LPS-activated J774A.1 murine macrophage cells, primary mice peritoneal macrophages, and JAWSII murine bone marrow-derived dendritic cells and reduced NLRP3 inflammasome-mediated interleukin-1beta (IL-1beta) secretion by LPS + adenosine triphosphate-activated J774A.1 and JAWSII cells.	Hydrogen	9-11	interleukin 1 beta	Mus musculus	256-273
24116148-6	2013	Compound 1h also reduced secretion of IL-6 and tumor necrosis factor-alpha by LPS-activated J774A.1 murine macrophage cells, primary mice peritoneal macrophages, and JAWSII murine bone marrow-derived dendritic cells and reduced NLRP3 inflammasome-mediated interleukin-1beta (IL-1beta) secretion by LPS + adenosine triphosphate-activated J774A.1 and JAWSII cells.	Hydrogen	9-11	interleukin 1 beta	Mus musculus	275-283
24116148-7	2013	The underlying mechanisms for the anti-inflammatory activity of compound 1h were found to be a decrease in LPS-induced reactive oxygen species (ROS) production, mitogen-activated protein kinase phosphorylation, and NF-kappaB activation and a decrease in ATP-induced ROS production and PKC-alpha phosphorylation.	Hydrogen	73-75	protein kinase C, alpha	Mus musculus	285-294
24088384-8	2013	Structural predictions, in combination with molecular dynamics simulations suggest that the repeat ensemble forms a beta-solenoid, namely a beta-helical fold with a polar core, stabilized by hydrogen-bonded ladders of polar residues.	Hydrogen	191-199	amyloid beta precursor protein	Homo sapiens	138-144
22618865-0	2013	1H, 13C and 15N resonance assignments of the pyrin domain from human PYNOD.	Hydrogen	0-2	NLR family pyrin domain containing 10	Homo sapiens	69-74
23526806-8	2013	This seems to be due to the ability of PGMA(rac) to form more intermolecular hydrogen bonds among polymer chains compared to the enantiopure PGMAs.	Hydrogen	77-85	AKT serine/threonine kinase 1	Homo sapiens	44-47
23001946-0	2013	1H, 13C and 15N assignments of Sgt2 N-terminal dimerisation domain and its binding partner, Get5 Ubiquitin-like domain.	Hydrogen	0-2	ubiquitin like 4A	Homo sapiens	92-96
22706932-0	2013	1H, 13C, 15N backbone and side-chain resonance assignments of the human adenylate kinase 1 in apo form.	Hydrogen	0-2	adenylate kinase 1	Homo sapiens	72-90
22744789-0	2013	1H, 13C and 15N chemical shift assignments of unliganded Bcl-xL and its complex with a photoresponsive Bak-derived peptide.	Hydrogen	0-2	BCL2 like 1	Homo sapiens	57-63
23070844-0	2013	1H, 15N and 13C backbone resonance assignments of the TPR1 and TPR2A domains of mouse STI1.	Hydrogen	0-2	stress-induced phosphoprotein 1	Mus musculus	86-90
23179057-0	2013	1H, 13C and 15N resonance assignments of human BASP1.	Hydrogen	0-2	brain abundant membrane attached signal protein 1	Homo sapiens	47-52
23863845-6	2013	Contrary to our previously studied wild-type (wt) p53-DNA complexes showing non-canonical Hoogsteen A/T base pairs of the DNA helix that lead to local minor-groove narrowing and enhanced electrostatic interactions with p53, the current structures display Watson-Crick base pairs associated with direct or water-mediated hydrogen bonds with p53 at the minor groove.	Hydrogen	320-328	tumor protein p53	Homo sapiens	50-53
23669417-1	2013	Investigation of bovine serum albumin by solid state hydrogen/deuterium exchange.	Hydrogen	53-61	albumin	Homo sapiens	24-37
23722000-1	2013	TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1h (time 1) and 2-3 days (time 2) after delivery in a group of healthy women (n=17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3 pg/ml median; 41.2 +- 15.9 mean +- SD) to time 2 (71.6 pg/ml median; 73.8 +- 27.8 mean +- SD).	Hydrogen	100-102	TNF superfamily member 10	Homo sapiens	0-37
23722000-1	2013	TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1h (time 1) and 2-3 days (time 2) after delivery in a group of healthy women (n=17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3 pg/ml median; 41.2 +- 15.9 mean +- SD) to time 2 (71.6 pg/ml median; 73.8 +- 27.8 mean +- SD).	Hydrogen	100-102	TNF superfamily member 10	Homo sapiens	39-44
24057168-0	2013	Quadruply hydrogen-bonded heteroduplexes based on imide and urea units arrayed with ADDA/DAAD sequences.	Hydrogen	10-18	adducin 1	Homo sapiens	84-88
23873754-2	2013	Recently we have shown that H2 S elicits acute pain through the activation of transient receptor potential ankyrin 1 (TRPA1), which is expressed mainly in primary nociceptive neurons.	Hydrogen	28-30	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	78-116
23873754-2	2013	Recently we have shown that H2 S elicits acute pain through the activation of transient receptor potential ankyrin 1 (TRPA1), which is expressed mainly in primary nociceptive neurons.	Hydrogen	28-30	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	118-123
23873754-3	2013	We also demonstrated enhancement of H2 S-induced TRPA1 activation and pain under inflammatory acidic conditions, but the underlying mechanism has not been elucidated.	Hydrogen	36-38	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	49-54
23792293-5	2013	Another band at 1293 cm(-1), assigned to the CH=CH in-plane rocking mode of the olefinic hydrogen is also observed in all samples, which reinforces the psittacofulvin compound as the main pigment present in the analyzed samples.	Hydrogen	89-97	churchill domain containing 1	Homo sapiens	45-50
23947824-12	2013	We show that a combination of DFT energies with small atom-centered basis sets, the D3 dispersion correction, and the gCP correction can accurately describe van der Waals and hydrogen-bonded crystals.	Hydrogen	175-183	golgin B1	Homo sapiens	118-121
23934108-5	2013	Structural and functional analysis illustrates that MEK inhibitors with superior efficacy in KRAS-driven tumours (GDC-0623 and G-573, the former currently in phase I clinical trials) form a strong hydrogen-bond interaction with S212 in MEK that is critical for blocking MEK feedback phosphorylation by wild-type RAF.	Hydrogen	197-205	mitogen-activated protein kinase kinase 7	Homo sapiens	52-55
23886708-4	2013	A specific hydrogen bond network rearrangement and improved electrostatic energy for hydroxylated P567 are compatible with an increase in HIF-1alpha binding affinity.	Hydrogen	11-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-148
23973327-3	2013	We use hydrogen-deuterium exchange coupled to mass spectrometry to characterize H2A-H2B and Nap1.	Hydrogen	7-15	nucleosome assembly protein 1 like 1	Homo sapiens	92-96
23811057-8	2013	A persistent V24-K28 bend motif, observed in all three species, is stabilized by buried backbone to side-chain hydrogen bonds with D23 and a cross-region salt bridge between E22 and K28, highlighting the role of the familial AD-linked E22 and D23 residues in Abeta monomer folding.	Hydrogen	111-119	amyloid beta precursor protein	Homo sapiens	259-264
24003111-11	2013	Integration of the hydrogen-deuterium exchange mass spectrometry results with computational docking resulted in models of the NOS heme and FMN subdomain bound to calmodulin.	Hydrogen	19-27	calmodulin 1	Homo sapiens	162-172
24147214-3	2013	Previous evidence in a Japanese population revealed that the homozygotes for allele T at position -511 of the interleukin (IL)-1beta gene promoter region (IL-1beta-511 T/T) confers susceptibility to the development of HS.	Hydrogen	218-220	interleukin 1 beta	Homo sapiens	110-132
24147214-3	2013	Previous evidence in a Japanese population revealed that the homozygotes for allele T at position -511 of the interleukin (IL)-1beta gene promoter region (IL-1beta-511 T/T) confers susceptibility to the development of HS.	Hydrogen	218-220	interleukin 1 beta	Homo sapiens	155-163
23708636-9	2013	This is likely because as opposed to SWNT and MWNT, O-SWNT binds CAT largely via hydrogen bonding and such interaction allows the CAT molecule to maintain the rigidity of enzyme structure and thus the biological function.	Hydrogen	81-89	catalase	Homo sapiens	65-68
23934108-5	2013	Structural and functional analysis illustrates that MEK inhibitors with superior efficacy in KRAS-driven tumours (GDC-0623 and G-573, the former currently in phase I clinical trials) form a strong hydrogen-bond interaction with S212 in MEK that is critical for blocking MEK feedback phosphorylation by wild-type RAF.	Hydrogen	197-205	mitogen-activated protein kinase kinase 7	Homo sapiens	236-239
23934108-5	2013	Structural and functional analysis illustrates that MEK inhibitors with superior efficacy in KRAS-driven tumours (GDC-0623 and G-573, the former currently in phase I clinical trials) form a strong hydrogen-bond interaction with S212 in MEK that is critical for blocking MEK feedback phosphorylation by wild-type RAF.	Hydrogen	197-205	mitogen-activated protein kinase kinase 7	Homo sapiens	236-239
23742976-9	2013	On the basis of docking studies, a direct hydrogen bond was formed between liensinine and arginine 482 which is a hot spot of BCRP for substrate specificity; and dauricine had hydrophobic interaction with BCRP.	Hydrogen	42-50	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	126-130
23742976-9	2013	On the basis of docking studies, a direct hydrogen bond was formed between liensinine and arginine 482 which is a hot spot of BCRP for substrate specificity; and dauricine had hydrophobic interaction with BCRP.	Hydrogen	42-50	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	205-209
24011181-2	2013	In this work, deoxygenation of technical grade methyl oleate to diesel fuel aliphatic hydrocarbons (C15 - C18) is evaluated with several parameters including temperature, hydrogen pressure and reaction time in a stirred batch reactor over Pd/SBA-15 catalysts.	Hydrogen	171-179	Bardet-Biedl syndrome 9	Homo sapiens	106-109
24011181-6	2013	Results show that H2 pressures greatly determine the total ester conversion and selectivity to C15 - C18 aliphatic hydrocarbons.	Hydrogen	18-20	Bardet-Biedl syndrome 9	Homo sapiens	101-104
23919805-7	2013	Over a wide potential window, the highly reactive nanostructure promotes the reduction of oxygen which rapidly discharges hydrogen from the PdH.	Hydrogen	122-130	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	140-143
23999301-8	2013	These studies revealed how the actin-binding helix undergoes a conformational change that increases the number of potential hydrogen bonds available for substrate binding.	Hydrogen	124-132	actin	Saccharomyces cerevisiae S288C	31-36
23959898-0	2013	Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Abeta) peptide aggregation.	Hydrogen	7-15	amyloid beta precursor protein	Homo sapiens	86-98
23959898-0	2013	Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Abeta) peptide aggregation.	Hydrogen	7-15	amyloid beta precursor protein	Homo sapiens	100-105
23835419-4	2013	Many arginine suppressors that mimic drug-rescue have been identified in the P-gp transmembrane (TM) domains (TMDs) that rescue by forming hydrogen bonds with residues in adjacent helices to promote packing of the TM segments.	Hydrogen	139-147	ATP binding cassette subfamily B member 1	Homo sapiens	77-81
23764826-6	2013	The calculated redox tuning of Co(I)H interactions on the reduction potential of Co(II)/Co(I) couple (60-800 mV vs standard hydrogen electrode (SHE)), irrespective of the beta-axial ligand considered, is significantly higher than the biological redox gap between the reduction potential of Co(II)/Co(I) couple and that of the biological reducing agents (50 mV vs SHE).	Hydrogen	124-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-87
23612553-8	2013	CONCLUSIONS: By the adoption of a new method for the comparison of cardiac troponin assays we showed that the hs-cTnT, hs-cTnI and Acc-cTnI assays had comparable prognostic properties, while the Arc-cTnI assay had inferior prognostic sensitivity.	Hydrogen	110-112	troponin T2, cardiac type	Homo sapiens	113-117
24010453-2	2013	The surface adsorption of hydrogen induces a hybridization change of carbon from the sp2 to the sp3 bond symmetry, which propagates through the graphene layers, resulting in interlayer carbon bond formation.	Hydrogen	26-34	Sp2 transcription factor	Homo sapiens	85-88
23999589-8	2013	It is suggested that the effect of TFE on both the soluble and aggregated states of URN1-FF depends on its ability to facilitate hydrogen bonding.	Hydrogen	129-137	transcription elongation regulator 1	Homo sapiens	84-88
23857929-10	2013	Moreover, 1,5-DAN matrix was used to study the H/D exchange profile of the methanol-induced helical structure of beta-endorphin, and the relative protection can be explained by the polarity of residues involved in hydrogen bond formation.	Hydrogen	214-222	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
23857929-10	2013	Moreover, 1,5-DAN matrix was used to study the H/D exchange profile of the methanol-induced helical structure of beta-endorphin, and the relative protection can be explained by the polarity of residues involved in hydrogen bond formation.	Hydrogen	214-222	proopiomelanocortin	Homo sapiens	113-127
23836912-4	2013	Here, using hydrogen/deuterium exchange, fluorescence anisotropy, and structural analyses, we show that the flexibility of the peptide binding groove of the class I MHC protein HLA-A*0201 varies significantly with different peptides.	Hydrogen	12-20	major histocompatibility complex, class I, A	Homo sapiens	177-182
24010453-2	2013	The surface adsorption of hydrogen induces a hybridization change of carbon from the sp2 to the sp3 bond symmetry, which propagates through the graphene layers, resulting in interlayer carbon bond formation.	Hydrogen	26-34	Sp3 transcription factor	Homo sapiens	96-99
23940735-10	2013	The structural model of the Der p 7-WH9 complex suggests residues S156, I157, L158, D159 and P160 of Der p 7 contribute to WH9 binding via potential hydrogen bonds, electrostatic and hydrophobic interactions.	Hydrogen	149-157	solute carrier family 10 member 7	Homo sapiens	32-35
23514259-10	2013	Except for the highest collision energy, 70-90% of the indirect reaction for the SN2 pathway occurs via formation of the hydrogen-bonded OH(-)---HCH2I prereaction complex.	Hydrogen	121-129	solute carrier family 38 member 5	Homo sapiens	81-84
23875785-0	2013	Structural insights into fibrinogen dynamics using amide hydrogen/deuterium exchange mass spectrometry.	Hydrogen	57-65	fibrinogen beta chain	Homo sapiens	25-35
23875785-1	2013	We determined the amide hydrogen/deuterium exchange profile of native human fibrinogen under physiologic conditions.	Hydrogen	24-32	fibrinogen beta chain	Homo sapiens	76-86
23911884-8	2013	The activation of NF-kappaB Signaling pathway was observed after 1h of ischemia and 1h of reperfusion, and Ruscogenin significantly inhibited NF-kappaB p65 expression, phosphorylation and translocation from cytosol to nucleus at this time point in a dose-dependent manner.	Hydrogen	65-67	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	18-27
23911884-8	2013	The activation of NF-kappaB Signaling pathway was observed after 1h of ischemia and 1h of reperfusion, and Ruscogenin significantly inhibited NF-kappaB p65 expression, phosphorylation and translocation from cytosol to nucleus at this time point in a dose-dependent manner.	Hydrogen	84-86	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	18-27
23815094-3	2013	Notably, these polymersomes displayed decent loading of bovine serum albumin (BSA), ovalbumin (OVA), and cytochrome C (CC) proteins likely due to presence of electrostatic and hydrogen bonding interactions between proteins and PDEA block located in the interior of polymersomes.	Hydrogen	176-184	albumin	Homo sapiens	63-76
23940735-10	2013	The structural model of the Der p 7-WH9 complex suggests residues S156, I157, L158, D159 and P160 of Der p 7 contribute to WH9 binding via potential hydrogen bonds, electrostatic and hydrophobic interactions.	Hydrogen	149-157	solute carrier family 10 member 7	Homo sapiens	105-108
23679855-5	2013	Huprine W forms additional interactions with hAChE, which explains its superior affinity: the isoquinoline moiety is associated with a group of aromatic residues (Tyr337, Phe338 and Phe295 not present in hBChE) in addition to Trp86; the hydroxyl group is hydrogen bonded to both the catalytic serine residue and residues in the oxyanion hole; and the chlorine substituent is nested in a hydrophobic pocket interacting strongly with Trp439.	Hydrogen	255-263	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-50
23727062-8	2013	Our results showed that the expression of Cdh1 was decreased while Skp2 (the downstream substrate of APC-Cdh1) was increased in astrocytes after 1h oxygen-glucose deprivation and reperfusion.	Hydrogen	145-147	cadherin 1	Homo sapiens	42-46
23080424-0	2013	Endogenous CSE/H2 S system mediates TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes.	Hydrogen	15-17	tumor necrosis factor	Homo sapiens	36-45
23080424-0	2013	Endogenous CSE/H2 S system mediates TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes.	Hydrogen	15-17	insulin	Homo sapiens	54-61
23080424-3	2013	We have hypothesized that TNF-alpha-induced insulin resistance is involved in endogenous H2 S generation.	Hydrogen	89-91	tumor necrosis factor	Homo sapiens	26-35
23080424-3	2013	We have hypothesized that TNF-alpha-induced insulin resistance is involved in endogenous H2 S generation.	Hydrogen	89-91	insulin	Homo sapiens	44-51
23080424-7	2013	Inhibited CSE by its potent inhibitors significantly attenuates TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes, whereas H2 S treatment of 3T3-L1 adipocytes impairs insulin-stimulated glucose consumption and uptake.	Hydrogen	131-133	insulin	Homo sapiens	175-182
23080424-9	2013	Our findings suggest that modulation of CSE/H2 S system is a potential therapeutic avenue for insulin resistance.	Hydrogen	44-46	insulin	Homo sapiens	94-101
23661708-9	2013	The molecular docking finally showed that EGCG formed several hydrogen bonds with the Thr190 residue of DCXR, and the model was further verified by site-directed mutagenesis.	Hydrogen	62-70	dicarbonyl and L-xylulose reductase	Homo sapiens	104-108
23742028-6	2013	Hydrogen has been reported to have the ability to inhibit levels of cytokines such as TNF, IL-6 in vivo.	Hydrogen	0-8	interleukin 6	Mus musculus	91-95
23727062-8	2013	Our results showed that the expression of Cdh1 was decreased while Skp2 (the downstream substrate of APC-Cdh1) was increased in astrocytes after 1h oxygen-glucose deprivation and reperfusion.	Hydrogen	145-147	cadherin 1	Homo sapiens	105-109
24100894-8	2013	Pretreatment with 10 mumol/L BAY-117082 for 1h significantly inhibited P.e-LPS-induced translocation of NF-kappaB .The mRNA and proteins of IL-6 decreased significantly after pretreatment with 10 mumol/L BAY-117082 and the expression of IL-6 proteins was reduced from (774.983+-6.585) ng/L to (377.384+-14.620) ng/L (P&lt;0.01).	Hydrogen	44-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	104-113
24100894-8	2013	Pretreatment with 10 mumol/L BAY-117082 for 1h significantly inhibited P.e-LPS-induced translocation of NF-kappaB .The mRNA and proteins of IL-6 decreased significantly after pretreatment with 10 mumol/L BAY-117082 and the expression of IL-6 proteins was reduced from (774.983+-6.585) ng/L to (377.384+-14.620) ng/L (P&lt;0.01).	Hydrogen	44-46	interleukin 6	Mus musculus	140-144
24100894-8	2013	Pretreatment with 10 mumol/L BAY-117082 for 1h significantly inhibited P.e-LPS-induced translocation of NF-kappaB .The mRNA and proteins of IL-6 decreased significantly after pretreatment with 10 mumol/L BAY-117082 and the expression of IL-6 proteins was reduced from (774.983+-6.585) ng/L to (377.384+-14.620) ng/L (P&lt;0.01).	Hydrogen	44-46	interleukin 6	Mus musculus	237-241
23777370-0	2013	The study of pH-dependent stability shows that the TPLH-mediated hydrogen-bonding network is important for the conformation and stability of human gankyrin.	Hydrogen	65-73	proteasome 26S subunit, non-ATPase 10	Homo sapiens	147-155
23750456-11	2013	As a consequence of its apparent high reactivity, the FpR intermediate was observed to undergo oxidation under oxygen-saturated conditions to yield another radical species, denoted as FOR, which subsequently underwent intramolecular hydrogen transfer (IHT) and dehydroxylation (DHO) to form a final product, which could react with the carboxyl from the decarboxylation reaction to generate a minor final product.	Hydrogen	233-241	formyl peptide receptor 1	Homo sapiens	54-57
24228592-5	2013	The results of the molecular modeling showed that the main interaction force between CGA and BLF or BSA was hydrogen bonds, together with Van der Waals" forces and hydrophobic effect.	Hydrogen	108-116	chromogranin A	Bos taurus	85-88
23796225-3	2013	Docking analysis showed that hydrophobic interaction and hydrogen bonding were created between the functional groups of Ace derivatives and the receptor sites of acetylcholinesterase.	Hydrogen	57-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	162-182
23706267-6	2013	Results of molecular docking studies revealed that COX-2 pharmacophore SO2NH2 in compound 30 is positioned in the secondary pocket of COX-2 active site; with the nitrogen atom of the SO2NH2 group being hydrogen bonded to Q192 (N OC=2.85A), and one of the oxygen atoms of SO2NH2 group forming a hydrogen bond to H90 (SO N=2.38A).	Hydrogen	202-210	prostaglandin-endoperoxide synthase 2	Homo sapiens	51-56
23706267-6	2013	Results of molecular docking studies revealed that COX-2 pharmacophore SO2NH2 in compound 30 is positioned in the secondary pocket of COX-2 active site; with the nitrogen atom of the SO2NH2 group being hydrogen bonded to Q192 (N OC=2.85A), and one of the oxygen atoms of SO2NH2 group forming a hydrogen bond to H90 (SO N=2.38A).	Hydrogen	294-302	prostaglandin-endoperoxide synthase 2	Homo sapiens	51-56
23706267-6	2013	Results of molecular docking studies revealed that COX-2 pharmacophore SO2NH2 in compound 30 is positioned in the secondary pocket of COX-2 active site; with the nitrogen atom of the SO2NH2 group being hydrogen bonded to Q192 (N OC=2.85A), and one of the oxygen atoms of SO2NH2 group forming a hydrogen bond to H90 (SO N=2.38A).	Hydrogen	294-302	prostaglandin-endoperoxide synthase 2	Homo sapiens	134-139
23706267-6	2013	Results of molecular docking studies revealed that COX-2 pharmacophore SO2NH2 in compound 30 is positioned in the secondary pocket of COX-2 active site; with the nitrogen atom of the SO2NH2 group being hydrogen bonded to Q192 (N OC=2.85A), and one of the oxygen atoms of SO2NH2 group forming a hydrogen bond to H90 (SO N=2.38A).	Hydrogen	202-210	prostaglandin-endoperoxide synthase 2	Homo sapiens	134-139
23293887-5	2013	The docking studies of most potent analog (7) with 3D crystal structure of the nuclear factor kappa-B (NF-kappaB) P50 homodimer (PDB ID: 1NFK) revealed that carbonyl group of ester side chain and C-28 carboxylic acid groups were mainly involved in hydrogen bonding interaction.	Hydrogen	248-256	nuclear factor kappa B subunit 1	Homo sapiens	79-101
23752612-2	2013	Ly49A is a mouse inhibitory receptor that binds with high affinity to H2(d) in both a cis- and trans-manner.	Hydrogen	70-72	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	0-5
23687377-4	2013	On the basis of the crystal structure of the Cx26 gap junction, we developed homology models for homotypic and heterotypic channels from Cx32 and/or Cx26; these models predict six hydrogen bonds at the docking interface of each pair of the second extracellular domain (E2).	Hydrogen	180-188	gap junction protein beta 2	Homo sapiens	45-49
23687377-4	2013	On the basis of the crystal structure of the Cx26 gap junction, we developed homology models for homotypic and heterotypic channels from Cx32 and/or Cx26; these models predict six hydrogen bonds at the docking interface of each pair of the second extracellular domain (E2).	Hydrogen	180-188	gap junction protein beta 2	Homo sapiens	149-153
23687377-8	2013	By testing more homotypic and heterotypic Cx32 and/or Cx26 mutant combinations, it is revealed that a minimum of four hydrogen bonds at each E2-docking interface are required for proper docking and functional channel formation between Cx26 and Cx32 hemichannels.	Hydrogen	118-126	gap junction protein beta 2	Homo sapiens	54-58
23687377-8	2013	By testing more homotypic and heterotypic Cx32 and/or Cx26 mutant combinations, it is revealed that a minimum of four hydrogen bonds at each E2-docking interface are required for proper docking and functional channel formation between Cx26 and Cx32 hemichannels.	Hydrogen	118-126	gap junction protein beta 2	Homo sapiens	235-239
23689510-6	2013	A crystal structure of Gipg013 Fab in complex with the human GIPr extracellular domain (ECD) shows that the antibody binds through a series of hydrogen bonds from the complementarity-determining regions of Gipg013 Fab to the N-terminal alpha-helix of GIPr ECD as well as to residues around its highly conserved glucagon receptor subfamily recognition fold.	Hydrogen	143-151	gastric inhibitory polypeptide receptor	Homo sapiens	61-65
23689510-6	2013	A crystal structure of Gipg013 Fab in complex with the human GIPr extracellular domain (ECD) shows that the antibody binds through a series of hydrogen bonds from the complementarity-determining regions of Gipg013 Fab to the N-terminal alpha-helix of GIPr ECD as well as to residues around its highly conserved glucagon receptor subfamily recognition fold.	Hydrogen	143-151	gastric inhibitory polypeptide	Homo sapiens	251-259
23293887-5	2013	The docking studies of most potent analog (7) with 3D crystal structure of the nuclear factor kappa-B (NF-kappaB) P50 homodimer (PDB ID: 1NFK) revealed that carbonyl group of ester side chain and C-28 carboxylic acid groups were mainly involved in hydrogen bonding interaction.	Hydrogen	248-256	nuclear factor kappa B subunit 1	Homo sapiens	103-112
23633025-1	2013	Exploration of the complex Ni2(MBD)4 (MBD = 2-mercaptobenzimidazole) (C1) having different coordinated Ni atoms as a photocatalyst for hydrogen evolution is made.	Hydrogen	135-143	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	27-36
23780977-6	2013	CONCLUSION: A hydrogen bond (ILY Arg432-hCD59 Glu76) was observed between ILY and hCD59, and a stronger interaction was formed by flexible adjustment between them.	Hydrogen	14-22	CD59 molecule (CD59 blood group)	Homo sapiens	40-45
23780977-6	2013	CONCLUSION: A hydrogen bond (ILY Arg432-hCD59 Glu76) was observed between ILY and hCD59, and a stronger interaction was formed by flexible adjustment between them.	Hydrogen	14-22	CD59 molecule (CD59 blood group)	Homo sapiens	82-87
23742697-4	2013	Incubation of human umbilical vein endothelial cells (HUVECs-926) with NaHS (a H2 S donor) stimulated the phosphorylation of endothelial NO synthase (eNOS) and enhanced NO production.	Hydrogen	79-81	nitric oxide synthase 3	Homo sapiens	150-154
23610159-0	2013	Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome.	Hydrogen	0-8	component of oligomeric golgi complex 2	Homo sapiens	36-51
23610159-3	2013	Serum analysis showed that consumption of H2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels.	Hydrogen	42-44	component of oligomeric golgi complex 2	Homo sapiens	124-139
23610159-3	2013	Serum analysis showed that consumption of H2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels.	Hydrogen	42-44	component of oligomeric golgi complex 2	Homo sapiens	141-146
23610159-5	2013	In addition, we found H2 significantly improved HDL functionality assessed in four independent ways, namely, i) protection against LDL oxidation, ii) inhibition of tumor necrosis factor (TNF)-alpha-induced monocyte adhesion to endothelial cells, iii) stimulation of cholesterol efflux from macrophage foam cells, and iv) protection of endothelial cells from TNF-alpha-induced apoptosis.	Hydrogen	22-24	tumor necrosis factor	Homo sapiens	164-197
23610159-5	2013	In addition, we found H2 significantly improved HDL functionality assessed in four independent ways, namely, i) protection against LDL oxidation, ii) inhibition of tumor necrosis factor (TNF)-alpha-induced monocyte adhesion to endothelial cells, iii) stimulation of cholesterol efflux from macrophage foam cells, and iv) protection of endothelial cells from TNF-alpha-induced apoptosis.	Hydrogen	22-24	tumor necrosis factor	Homo sapiens	358-367
23610159-7	2013	In conclusion, supplementation with H2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome.	Hydrogen	36-38	component of oligomeric golgi complex 2	Homo sapiens	74-79
23610159-7	2013	In conclusion, supplementation with H2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome.	Hydrogen	36-38	apolipoprotein B	Homo sapiens	84-88
23660848-9	2013	CONCLUSIONS: NT-proBNP and hs-cTnT are independently associated with silent MRI-defined BI and WML, suggesting that cardiovascular biomarkers may be useful to identify individuals with subclinical cerebral injury.	Hydrogen	27-29	troponin T2, cardiac type	Homo sapiens	30-34
23583481-7	2013	Quantitative light microscopy revealed a significant increase in pDOR-ir in the CA2/CA3a region of male rats 1h following an injection of the opioid agonist morphine (20mg/kg, I.P).	Hydrogen	109-111	carbonic anhydrase 2	Rattus norvegicus	80-83
23665537-3	2013	In the presence of target ds-DNA (the PPT of HIV RNA, a 16-bp ds-DNA sequence), the TFO could interact with the major groove in ds-DNA (via Hoogsteen hydrogen bonding) to form a rigid triplex structure, resulting in fluorescence recovery.	Hydrogen	150-158	tachykinin precursor 1	Homo sapiens	38-41
23799921-6	2013	Acute stroke patients within 3 h of onset received intravenous tissue plasminogen activator (t-PA) (0.6 mg/kg) treatment, and patients receiving t-PA had to commence the administration of the H2-enriched intravenous solution and edaravone before or at the same time as the t-PA was infused.	Hydrogen	192-194	plasminogen activator, tissue type	Homo sapiens	145-149
23799921-13	2013	CONCLUSIONS: Data from the current study indicate that an H2-enriched intravenous solution is safe for patients with acute cerebral infarction, including patients treated with t-PA.	Hydrogen	58-60	plasminogen activator, tissue type	Homo sapiens	176-180
23763845-3	2013	METHODS: Samples from 60 patients were divided into equal aliquots and placed into RSTs and SSTs; hs-cTnT and CK-MB concentrations were determined using an autoanalyzer (Elecsys 2010) running commercial assays (Roche Diagnostics, Penzberg, Germany).	Hydrogen	98-100	troponin T2, cardiac type	Homo sapiens	101-105
23625926-7	2013	The results suggest that the S186W mutant thermally destabilizes rhodopsin by disrupting a hydrogen bond network at the receptor"s active site.	Hydrogen	91-99	rhodopsin	Homo sapiens	65-74
23738738-11	2013	CONCLUSIONS: The results show that the hydrogen bonding and van der Waals forces play major roles in stabilizing the 1:1 INH-SOD complex.	Hydrogen	39-47	superoxide dismutase 1	Homo sapiens	125-128
23692429-3	2013	On the basis of cyclic voltammetry measurements, surface-bound Co(II) undergoes a pH-dependent 1e(-)/1H(+) oxidation to Co(III), which is followed by pH-dependent catalytic water oxidation.	Hydrogen	101-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
23692429-3	2013	On the basis of cyclic voltammetry measurements, surface-bound Co(II) undergoes a pH-dependent 1e(-)/1H(+) oxidation to Co(III), which is followed by pH-dependent catalytic water oxidation.	Hydrogen	101-103	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	120-127
23772214-0	2013	Cholesterol accelerates the binding of Alzheimer"s beta-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation.	Hydrogen	111-119	amyloid beta precursor protein	Homo sapiens	51-71
23744388-3	2013	The contribution from weaker C-H   O hydrogen bonds is much more evident in the structure of (II), which furthermore contains an example of a direct short Osp(3)   Csp(2) contact that represents a usually unrecognized type of intermolecular interaction.	Hydrogen	37-45	claudin 11	Homo sapiens	155-158
23735897-9	2013	CONCLUSIONS: In unselected ED patients the diagnostic performances of hs-cTnT and standard cTnT for AMI diagnosis did not differ significantly.	Hydrogen	70-72	troponin T2, cardiac type	Homo sapiens	73-77
23504664-7	2013	Based on the virtual screening and on the results obtained above, the activity may be due to their capacity to reduce the NO synthesis by blocking the bind of L-Arg in the active site of iNOS, the compounds binding the synthase by hydrogen bonds between the NH (2 and/or 4) of thiosemicarbazide fragment (Th-2-8) or N2/N3 from azole cycles and by the thiol function (Th-9-22).	Hydrogen	231-239	nitric oxide synthase 2	Homo sapiens	187-191
23194423-9	2013	In silico data suggest that modifications to the basic AA structure change the hydrogen-bonding network with the AR ligand binding domain (LBD), so that the para-hydroxyl group of AA forms a hydrogen bond with the LBD, confirming the functional importance of this group for AR antagonism.	Hydrogen	79-87	androgen receptor	Homo sapiens	113-115
23194423-9	2013	In silico data suggest that modifications to the basic AA structure change the hydrogen-bonding network with the AR ligand binding domain (LBD), so that the para-hydroxyl group of AA forms a hydrogen bond with the LBD, confirming the functional importance of this group for AR antagonism.	Hydrogen	191-199	androgen receptor	Homo sapiens	113-115
23611768-3	2013	The results demonstrated that at its 4"-position of 5,4"-difluoroflavone the substituents may face Arg752 and that in AR-LBD, the submolecular bulk of substituents is unfavorable for AR antagonists and the negative electrostatic interaction site prefers the stronger hydrogen bond capability of substituents of AR antagonists.	Hydrogen	267-275	androgen receptor	Homo sapiens	118-120
23220415-0	2013	Analysis of the local dynamics of human insulin and a rapid-acting insulin analog by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	85-93	insulin	Homo sapiens	40-47
23220415-0	2013	Analysis of the local dynamics of human insulin and a rapid-acting insulin analog by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	85-93	insulin	Homo sapiens	67-74
23220415-3	2013	In our previous study performed using hydrogen/deuterium exchange mass spectrometry (HDX/MS), differences were observed in the rates and levels of deuteration among insulin analog products, which were found to be related to their self-association stability.	Hydrogen	38-46	insulin	Homo sapiens	165-172
23131022-5	2013	RESULTS: Studies have shown that increase in H2 S concentration could reduce the expression of UII, UT, collagen I, collagen III, TIMP-1 and alpha-SMA without involvement of CSE.	Hydrogen	45-47	TIMP metallopeptidase inhibitor 1	Homo sapiens	130-136
23557746-1	2013	Replacement of hydrogen with fluorine within three pairs of structurally similar small molecule inhibitors of heat shock protein 90 (HSP90) resulted in differences in inhibition constants (K(i)) in vitro as well as marked differences in rat intravenous pharmacokinetic profiles.	Hydrogen	15-23	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	110-131
23557746-1	2013	Replacement of hydrogen with fluorine within three pairs of structurally similar small molecule inhibitors of heat shock protein 90 (HSP90) resulted in differences in inhibition constants (K(i)) in vitro as well as marked differences in rat intravenous pharmacokinetic profiles.	Hydrogen	15-23	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	133-138
23563626-0	2013	Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis.	Hydrogen	0-8	BCL2, apoptosis regulator	Rattus norvegicus	88-93
23947022-2	2013	The effects of O2 and H2 in Ar gas on the removal of CS2 were examined.	Hydrogen	22-24	chorionic somatomammotropin hormone 2	Homo sapiens	53-56
23947022-5	2013	The main gaseous products of CS2 decomposition with the addition of O2 in Ar gas were CO, CO2 COS and SO2, while, with the presence of H2 in Ar gas, the main products of CS2 decomposition were H2S and CH4.	Hydrogen	135-137	chorionic somatomammotropin hormone 2	Homo sapiens	170-173
23563626-9	2013	In conclusion, hydrogen exhibits significant protective effects against AGE-induced EC injury possibly through reducing ROS generation, intracellular antioxidant enzyme system protection and elevation of the Bcl-2/Bax ratio.	Hydrogen	15-23	BCL2, apoptosis regulator	Rattus norvegicus	208-213
23621790-0	2013	New insights into the folding of a beta-sheet miniprotein in a reduced space of collective hydrogen bond variables: application to a hydrodynamic analysis of the folding flow.	Hydrogen	91-99	amyloid beta precursor protein	Homo sapiens	33-39
23030661-16	2013	CONCLUSION: Following incubation with H2 S , OKSCs express multiple p53-associated genes, including programmed cell death, cell-cycle control and DNA-repair genes.	Hydrogen	38-40	tumor protein p53	Homo sapiens	68-71
23697416-0	2013	Direct-dynamics VTST study of hydrogen or deuterium abstraction and C-C bond formation or dissociation in the reactions of CH3 + CH4, CH3 + CD4, CH3D + CD3, CH3CH3 + H, and CH3CD3 + D. Direct-dynamics variational transition-state theory calculations are studied at the MPWB1K/6-311++G(d,p) level for the four parts of reactions.	Hydrogen	30-38	CD4 molecule	Homo sapiens	140-143
23697416-1	2013	The first part is hydrogen or deuterium abstraction in the reactions of CH3 + CH4, CH3 + CD4, and CH3D + CH3.	Hydrogen	18-26	CD4 molecule	Homo sapiens	89-92
23586743-2	2013	The reaction of cyc-N3 with hydrogen is shown to proceed through a barrierless path that dissociates to N2 + NH((1)Delta) without reaching the HN3 global minimum.	Hydrogen	28-36	cytochrome c, somatic	Homo sapiens	16-19
23475767-0	2013	Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.	Hydrogen	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	51-55
23475767-4	2013	We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and induced heme oxygenase (HO)-1.	Hydrogen	38-46	heme oxygenase 1	Mus musculus	98-119
23475767-8	2013	Hydrogen treatment during exposure to hyperoxia significantly improved blood oxygenation, reduced inflammatory events, and induced HO-1 expression.	Hydrogen	0-8	heme oxygenase 1	Mus musculus	131-135
23475767-10	2013	These findings indicate that hydrogen gas can ameliorate hyperoxic lung injury through induction of Nrf2-dependent genes, such as HO-1.	Hydrogen	29-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	100-104
23475767-10	2013	These findings indicate that hydrogen gas can ameliorate hyperoxic lung injury through induction of Nrf2-dependent genes, such as HO-1.	Hydrogen	29-37	heme oxygenase 1	Mus musculus	130-134
23403030-4	2013	The second transition is accompanied by CaM folding into a tighter, less hydrogen-exchangeable structure, and is completed by the addition of the fourth Ca(2+) to have four Ca(2+) per molecule.	Hydrogen	73-81	calmodulin 1	Homo sapiens	40-43
23485707-1	2013	Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio.	Hydrogen	113-117	aquaporin 1 (Colton blood group)	Homo sapiens	26-37
23485707-1	2013	Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio.	Hydrogen	113-117	aquaporin 1 (Colton blood group)	Homo sapiens	39-43
23369733-7	2013	CRF (1muM, 1h, n=5) stimulation also induced colonic secretion of IL-6 and inhibited the pro-secretory effects of IL-6 on colonic ion transfer (n=12).	Hydrogen	11-13	interleukin 6	Rattus norvegicus	66-70
23369733-7	2013	CRF (1muM, 1h, n=5) stimulation also induced colonic secretion of IL-6 and inhibited the pro-secretory effects of IL-6 on colonic ion transfer (n=12).	Hydrogen	11-13	interleukin 6	Rattus norvegicus	114-118
23850671-5	2013	Concentration of IL-6 and hepcidin increased 1h after exercise in both groups (p&lt;0.05).	Hydrogen	45-47	interleukin 6	Homo sapiens	17-21
23541574-9	2013	The 1h cyclic stretching protocol acutely increased the phosphorylation of Akt (+4.5-fold; P&lt;0.05) and its downstream targets, FOXO3a (+4.2-fold; P&lt;0.05) and GSK-3beta (+1.8-fold; P&lt;0.05), which returned to baseline by 48 h after cessation of stretch.	Hydrogen	4-6	AKT serine/threonine kinase 1	Homo sapiens	75-78
23541574-9	2013	The 1h cyclic stretching protocol acutely increased the phosphorylation of Akt (+4.5-fold; P&lt;0.05) and its downstream targets, FOXO3a (+4.2-fold; P&lt;0.05) and GSK-3beta (+1.8-fold; P&lt;0.05), which returned to baseline by 48 h after cessation of stretch.	Hydrogen	4-6	forkhead box O3	Homo sapiens	130-136
22715144-2	2013	A metal ion-chelating ligand complex with a Co(II) ion and a chelating reagent like ethylenediaminetetraacetic acid (EDTA) produced highly enhanced chemiluminescence (CL) intensity as well as longer lifetime in the luminol-H2 O2 system compared to metals that exist as free ions.	Hydrogen	223-225	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-50
23538097-7	2013	SF-induced phosphorylation of EGFR for 1h was partly reversible upon removal of the dendrimer and examination of cells 24 later.	Hydrogen	39-41	epidermal growth factor receptor	Homo sapiens	30-34
23473947-4	2013	In molecular modeling, interaction of 2-sulfonylalkyl moiety with Arg120 in COX-1 and an extra hydrogen bond with Tyr341 in COX-2 increased the residence time of ligands in the active site in 2-sulfonylalkyl and 2-alkylthio analogs, respectively.	Hydrogen	95-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
23521110-7	2013	Computational modeling indicated that 1 can bind to PPARalpha, gamma, and delta each in a distinct manner, while it can activate PPARalpha only by forming a hydrogen bond with Y464, thus stabilizing the AF-2 helix and activating PPARalpha.	Hydrogen	157-165	peroxisome proliferator activated receptor alpha	Mus musculus	129-138
23521110-7	2013	Computational modeling indicated that 1 can bind to PPARalpha, gamma, and delta each in a distinct manner, while it can activate PPARalpha only by forming a hydrogen bond with Y464, thus stabilizing the AF-2 helix and activating PPARalpha.	Hydrogen	157-165	peroxisome proliferator activated receptor alpha	Mus musculus	129-138
23490150-4	2013	An X-ray co-crystal structure of 19b with EGFR demonstrated that the N-1 and N-3 nitrogens of the pyrimido[4,5-b]azepine scaffold make hydrogen-bonding interactions with the main chain NH of Met793 and the side chain of Thr854 via a water-mediated hydrogen bond network, respectively.	Hydrogen	135-143	epidermal growth factor receptor	Homo sapiens	42-46
23450835-1	2013	Hydrogen-treated TiO2 nanotube (H-TNT) arrays serve as highly ordered nanostructured electrode supports, which are able to significantly improve the electrochemical performance and durability of fuel cells.	Hydrogen	0-8	chromosome 16 open reading frame 82	Homo sapiens	34-37
23517305-12	2013	Glu(57") and Glu(58") present in the hirudin family of inhibitors make up a key binding epitope of fibrinogen, thrombin"s prime substrate, which lends substantial interest to the short hydrogen bond as a binding element at the fibrinogen recognition site.	Hydrogen	185-193	fibrinogen beta chain	Homo sapiens	99-109
23517305-12	2013	Glu(57") and Glu(58") present in the hirudin family of inhibitors make up a key binding epitope of fibrinogen, thrombin"s prime substrate, which lends substantial interest to the short hydrogen bond as a binding element at the fibrinogen recognition site.	Hydrogen	185-193	coagulation factor II, thrombin	Homo sapiens	111-119
23517305-12	2013	Glu(57") and Glu(58") present in the hirudin family of inhibitors make up a key binding epitope of fibrinogen, thrombin"s prime substrate, which lends substantial interest to the short hydrogen bond as a binding element at the fibrinogen recognition site.	Hydrogen	185-193	fibrinogen beta chain	Homo sapiens	227-237
23723870-8	2013	In the crystal, the pyridine N atom accepts a hydrogen bond from the N-H group of the 1,4-DHP ring.	Hydrogen	46-54	dihydropyrimidinase	Homo sapiens	90-93
23723833-2	2013	In the crystal, weak C-H N and C-H Br hydrogen bonds link the mol-ecules into double chains propagating along [01-1].	Hydrogen	38-46	nuclear receptor subfamily 4 group A member 3	Homo sapiens	21-34
23479651-3	2013	Here, we report the crystal structure of the relevant free Nup54 segment and show that it forms a tetrameric, helical bundle that is structurally "conditioned" for instability by a central patch of polar hydrogen-bonded residues.	Hydrogen	204-212	nucleoporin 54	Homo sapiens	59-64
23420844-3	2013	Homology modeling of mGluR8 transmembrane domain with rhodopsin as a template suggested the presence of a conserved water-mediated hydrogen-bonding network between helices VI and VII, which presumably constrains the receptor in an inactive conformation.	Hydrogen	131-139	rhodopsin	Homo sapiens	54-63
23403296-11	2013	Tyrosol esters with a phenolic acid containing hydrogen bond donor and/or acceptor groups at the para-position have better anticancer and c-MET inhibitory activities.	Hydrogen	47-55	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	138-143
22639973-6	2013	KEY RESULTS Calculated hydrogen bonding energies between a series of synthetic carboxylic acid compounds and the homology models of the FFA1 receptor and GPR120, using docking simulations, correlated well with the effects of the compounds on ERK phosphorylation in transfected cells (R(2) = 0.65 for FFA1 receptor and 0.76 for GPR120).	Hydrogen	23-31	mitogen-activated protein kinase 1	Mus musculus	242-245
23450835-9	2013	X-ray photoelectron spectroscopy shows that after the H-TNT-loaded Pt catalysts are annealed in H2 for the second time, the strong metal-support interaction between the H-TNTs and the Pt catalysts enhances the electrochemical stability of the electrodes.	Hydrogen	96-98	chromosome 16 open reading frame 82	Homo sapiens	56-59
23661516-0	2013	Hydrogen-rich saline reduces airway remodeling via inactivation of NF-kappaB in a murine model of asthma.	Hydrogen	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	67-76
23661516-7	2013	RESULTS: The results showed that hydrogen-rich saline reduced cell counts and levels of cytokines IL-4, IL-5, IL-13 and TNF-alpha in BALF.	Hydrogen	33-41	interleukin 13	Mus musculus	110-115
23661516-7	2013	RESULTS: The results showed that hydrogen-rich saline reduced cell counts and levels of cytokines IL-4, IL-5, IL-13 and TNF-alpha in BALF.	Hydrogen	33-41	tumor necrosis factor	Mus musculus	120-129
23661516-8	2013	Hydrogen-rich saline treatment also significantly decreased mucus index, collagen deposition, and expression of MUC5AC, collagen III and VEGF.	Hydrogen	0-8	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	112-118
23661516-9	2013	The ratio of phospho-NF-kappaB p65 to total NF-kappaB p65 was much lower in mice treated with hydrogen-rich saline than in untreated mice.	Hydrogen	94-102	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	21-30
23661516-9	2013	The ratio of phospho-NF-kappaB p65 to total NF-kappaB p65 was much lower in mice treated with hydrogen-rich saline than in untreated mice.	Hydrogen	94-102	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-53
23661516-11	2013	CONCLUSIONS: These findings suggest that hydrogen-rich saline reduces airway inflammation and remodeling in OVA-exposed mice by inhibiting NF-kappaB.	Hydrogen	41-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	139-148
23467020-4	2013	When the steroidal EST is divided into two functional units including "A ring" and "D ring", respectively, the FMO4-IFIE analysis reveals their binding affinity with surrounding fragments of the amino acid residues; the "A ring" of EST has polarization interaction with the main chain of Thr347 and two hydrogen bonds with the side chains of Glu353 and Arg394; the "D ring" of EST has a hydrogen bond with the side chain of His524.	Hydrogen	303-311	flavin containing dimethylaniline monoxygenase 4	Homo sapiens	111-115
23349207-4	2013	Modeling studies indicate that apoA1 is folded onto itself in nHDL(DMPC), making a large hairpin, which was also confirmed independently by both cross-linking mass spectrometry and hydrogen-deuterium exchange (HDX) mass spectrometry analyses.	Hydrogen	181-189	apolipoprotein A1	Homo sapiens	31-36
23467020-4	2013	When the steroidal EST is divided into two functional units including "A ring" and "D ring", respectively, the FMO4-IFIE analysis reveals their binding affinity with surrounding fragments of the amino acid residues; the "A ring" of EST has polarization interaction with the main chain of Thr347 and two hydrogen bonds with the side chains of Glu353 and Arg394; the "D ring" of EST has a hydrogen bond with the side chain of His524.	Hydrogen	387-395	flavin containing dimethylaniline monoxygenase 4	Homo sapiens	111-115
23827636-11	2013	Phospho-ERK was activated by 50 muM PS at 30 min and 1h in growth medium.	Hydrogen	53-55	mitogen-activated protein kinase 1	Homo sapiens	8-11
23337108-2	2013	In the previously solved structure of TDG in complex with DNA containing 5caC, the side chain of asparagine 157 (N157) contacts the 5-carboxyl moiety of 5caC via a weak hydrogen bond.	Hydrogen	169-177	thymine DNA glycosylase	Homo sapiens	38-41
23440928-8	2013	Finally, MD simulations of aggregation-prone Abeta heptapeptide segments show that carnosine reduces the propensity to form intermolecular backbone hydrogen bonds in the region 18-24.	Hydrogen	148-156	amyloid beta precursor protein	Homo sapiens	45-50
23136124-0	2013	Matrix-isolated hydrogen-bonded and van der Waals complexes of hydrogen peroxide with OCS and CS2.	Hydrogen	16-24	chorionic somatomammotropin hormone 2	Homo sapiens	94-97
23762937-8	2010	We show that ML310 can displace T1317 in a binding assay and does interact with RORgamma protein to stabilize the protein in hydrogen-deuterium exchange (HDX)-based experiments.	Hydrogen	125-133	RAR-related orphan receptor gamma	Mus musculus	80-88
23281120-1	2013	The hydrogen-bonded complexes of phenylacetylene, 4-fluorophenylacetylene, 2-fluorophenylacetylene, and 2,6-difluorophenylacetylene with ammonia are investigated using IR-UV double resonance spectroscopy in combination with high-level ab initio calculations at the CCSD(T)/CBS level of theory.	Hydrogen	4-12	cystathionine beta-synthase	Homo sapiens	273-276
23503500-5	2013	In recent years, hydrogen was reported to have an ability to inhibit the levels of cytokines, such as tumor necrosis factor and interleukin-6 in vivo, and it also has a strong selective free radical-scavenging ability.	Hydrogen	17-25	interleukin 6	Mus musculus	128-141
23473504-0	2013	Conformational effects on the pro-S hydrogen abstraction reaction in cyclooxygenase-1: an integrated QM/MM and MD study.	Hydrogen	36-44	prostaglandin-endoperoxide synthase 1	Homo sapiens	69-85
23379419-5	2013	The simulations suggest that the G2019S mutation stabilizes the DYG-in state of LRRK2 through a series of hydrogen bonds, leading to an increase in the conformational barrier between the active and inactive forms of the enzyme and a relative stabilization of the active form.	Hydrogen	106-114	leucine rich repeat kinase 2	Homo sapiens	80-85
23473504-1	2013	A key step in the cyclooxygenase reaction cycle of cyclooxygenase 1 (COX-1) is abstraction of the pro-S hydrogen atom of the arachidonic acid by a radical that is formed at the protein residue Tyr-385.	Hydrogen	104-112	prostaglandin-endoperoxide synthase 1	Homo sapiens	51-67
23473504-1	2013	A key step in the cyclooxygenase reaction cycle of cyclooxygenase 1 (COX-1) is abstraction of the pro-S hydrogen atom of the arachidonic acid by a radical that is formed at the protein residue Tyr-385.	Hydrogen	104-112	prostaglandin-endoperoxide synthase 1	Homo sapiens	69-74
23339966-6	2013	Interestingly, docking of the two active molecules 3k and 3w into the active site of COX-2 indicates that these compounds are COX-2 ligands with strong hydrophobic and hydrogen bonding interactions.	Hydrogen	168-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
23339484-5	2013	The common feature pharmacophore indicated that two hydrophobes and one hydrogen bond acceptor were important for inhibition of NTCP.	Hydrogen	72-80	solute carrier family 10 member 1	Homo sapiens	128-132
23398593-10	2013	The desolvated Co(II)(pybz)2 can absorb several gases such as CO2, N2, H2, and CH4 and also vapors of methanol, ethanol, benzene, and cyclohexane.	Hydrogen	71-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
23339966-6	2013	Interestingly, docking of the two active molecules 3k and 3w into the active site of COX-2 indicates that these compounds are COX-2 ligands with strong hydrophobic and hydrogen bonding interactions.	Hydrogen	168-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
23360482-4	2013	In contrast, the hydrogen radical transfer reaction was suppressed by using ionic liquid and amorphous structure of 2,5-DHB and 1,5-DAN mixture as a matrix.	Hydrogen	17-25	NBL1, DAN family BMP antagonist	Homo sapiens	132-135
23340693-9	2013	These results showed that hydrogen-rich saline was able to attenuate             FBS-induced VSMC proliferation and neointimal hyperplasia by inhibiting ROS production             and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways.	Hydrogen	26-34	AKT serine/threonine kinase 1	Rattus norvegicus	223-226
23334161-7	2013	In reduced cytochrome c the G41T and G41S mutations had distinct effects on a network of hydrogen bonds involving Met-80, and in G41T the conformational mobility of two Omega-loops was altered.	Hydrogen	89-97	cytochrome c, somatic	Homo sapiens	11-23
23440275-6	2013	Because the concentrations of calcium and hydrogen ions increase toward the center of the lens, a concentration signal could trigger a regulatory change in AQP0 water permeability.	Hydrogen	42-50	major intrinsic protein of lens fiber S homeolog	Xenopus laevis	156-160
23200735-5	2013	We also found that QT (50 muM) increased the expressions of AR and ER-alpha in the presence of a sub-threshold level of cyclic-AMP at 1h culture period to the levels seen with maximal stimulation of cyclic-AMP.	Hydrogen	134-136	latexin	Homo sapiens	26-29
23200735-5	2013	We also found that QT (50 muM) increased the expressions of AR and ER-alpha in the presence of a sub-threshold level of cyclic-AMP at 1h culture period to the levels seen with maximal stimulation of cyclic-AMP.	Hydrogen	134-136	androgen receptor	Homo sapiens	60-62
23200735-5	2013	We also found that QT (50 muM) increased the expressions of AR and ER-alpha in the presence of a sub-threshold level of cyclic-AMP at 1h culture period to the levels seen with maximal stimulation of cyclic-AMP.	Hydrogen	134-136	estrogen receptor 1	Homo sapiens	67-75
23348103-4	2013	Contour map of variable coefficients showed that hydrogen bonding between the O atom in PO and the NH groups in acetylcholinesterase (AChE) played an important role in the interaction between OP and AChE.	Hydrogen	49-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-138
23348103-4	2013	Contour map of variable coefficients showed that hydrogen bonding between the O atom in PO and the NH groups in acetylcholinesterase (AChE) played an important role in the interaction between OP and AChE.	Hydrogen	49-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	199-203
23340693-0	2013	Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation             and neointimal hyperplasia by inhibiting reactive oxygen species production and             inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways.	Hydrogen	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	217-220
23354472-0	2013	Which hydrogen atom of toluene protonates PAH molecules in (+)-mode APPI MS analysis?	Hydrogen	6-14	amyloid beta precursor protein	Homo sapiens	68-72
23448206-6	2013	RESULTS: Pretreatment with hydrogen reduced fatty acid uptake and lipid accumulation after palmitate overload in HepG2 cells, which was associated with inhibition of JNK activation.	Hydrogen	27-35	mitogen-activated protein kinase 8	Homo sapiens	166-169
23258532-2	2013	H(2) is generated mostly by the [Fe-Fe]-hydrogenase HYDA1, which uses plant type ferredoxin PETF/FDX1 (PETF) as an electron donor.	Hydrogen	0-4	uncharacterized protein	Chlamydomonas reinhardtii	92-96
22765351-9	2013	For (GtK + 2H)(+ ), these excited states were characterized by time-dependent density functional theory as A-C states that had large components of Rydberg-like 3s molecular orbitals at the N-terminal and lysine ammonium groups that are conducive to hydrogen atom loss.	Hydrogen	249-257	kynurenine aminotransferase 1	Homo sapiens	5-8
23343309-5	2013	The results of the study on the quinoxaline   (H(2)O)(n) show that the preferred adducts in vacuo involve one, two, or three water molecules hydrogen bonded to the N atom and the neighboring H atom of the C(sp2)-H group.	Hydrogen	141-149	Sp2 transcription factor	Homo sapiens	205-210
23399272-7	2013	The 17% HA-insulin conjugate showed a lowering effect on blood glucose level for up to 6h, while free insulin exhausted its action after 1h.	Hydrogen	137-139	insulin	Homo sapiens	102-109
23258532-2	2013	H(2) is generated mostly by the [Fe-Fe]-hydrogenase HYDA1, which uses plant type ferredoxin PETF/FDX1 (PETF) as an electron donor.	Hydrogen	0-4	uncharacterized protein	Chlamydomonas reinhardtii	103-107
22565822-7	2013	Computational modeling showed that emodin could directly bind to the BH3 domain of Bcl-2 through forming one hydrogen bond with Ala146 residue in Bcl-2.	Hydrogen	109-117	BCL2 apoptosis regulator	Homo sapiens	83-88
23247439-10	2013	Autodock simulations predicted that TMP could directly bind to ERK2 with two hydrogen bonds and low energy score, indicating that ERK2 could be a direct target molecule for TMP within HSCs.	Hydrogen	77-85	mitogen-activated protein kinase 1	Homo sapiens	63-67
23247439-10	2013	Autodock simulations predicted that TMP could directly bind to ERK2 with two hydrogen bonds and low energy score, indicating that ERK2 could be a direct target molecule for TMP within HSCs.	Hydrogen	77-85	mitogen-activated protein kinase 1	Homo sapiens	130-134
23273518-2	2013	The binding mechanism of these compounds with estrogen receptor-alpha was rationalized by molecular docking studies which indicated additional hydrogen binding interactions and tight binding in the protein cavity.	Hydrogen	143-151	estrogen receptor 1	Homo sapiens	46-69
23697103-2	2013	P-2, P-3 and P-4 were characterized by 31P NMR, 1H NMR, IR, UV-Vis, GPC, TG and DSC.	Hydrogen	48-50	exosome component 10	Homo sapiens	0-16
23212785-4	2013	Analysis of the fluorescence quenching spectra indicates that the tungstenocene complexes bind HSA by hydrophobic interactions and hydrogen bonding at fatty acid binding site 6 and drug binding site II.	Hydrogen	131-139	albumin	Homo sapiens	95-98
23212785-5	2013	Docking studies provided a description of the hydrophobic interactions and hydrogen bonding by which the tungstenocenes become engaged with HSA.	Hydrogen	75-83	albumin	Homo sapiens	140-143
23212785-6	2013	It was determined that the binding affinity of the tungstenoecenes for HSA is in the order Cp(2)WCl(2) &lt; [Cp(2)W(ethyl maltolato)]Cl &lt; [Cp(2)W(maltolato)]Cl &lt; [Cp(2)W(kojato)]Cl, consistent with the hydrophobic interactions and the number of hydrogen bonds involved.	Hydrogen	251-259	albumin	Homo sapiens	71-74
23273744-7	2013	Hydrogen decreased the amount of IL-8 and TNF-alpha in serum, inhibited the activity of malondialdehyde and myeloperoxidase, and increased the activity of superoxide dismutase in the lung grafts from brain-dead donors.	Hydrogen	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
23273744-7	2013	Hydrogen decreased the amount of IL-8 and TNF-alpha in serum, inhibited the activity of malondialdehyde and myeloperoxidase, and increased the activity of superoxide dismutase in the lung grafts from brain-dead donors.	Hydrogen	0-8	tumor necrosis factor	Homo sapiens	42-51
23273744-7	2013	Hydrogen decreased the amount of IL-8 and TNF-alpha in serum, inhibited the activity of malondialdehyde and myeloperoxidase, and increased the activity of superoxide dismutase in the lung grafts from brain-dead donors.	Hydrogen	0-8	myeloperoxidase	Homo sapiens	108-123
23273744-8	2013	Furthermore, hydrogen decreased the apoptotic index of the cells and inhibited the protein expression of intercellular adhesion molecule-1 and caspase-3 in lung grafts from brain-dead donors.	Hydrogen	13-21	caspase 3	Homo sapiens	143-152
23318673-7	2013	Exposure of neurons to LTD4 for 1h showed activation of NF-kappaB pathway, by assessing the levels of p65 or phospho-p65 in the nucleus, and either CysLT(1)R antagonist pranlukast or NF-kappaB inhibitor PDTC prevented the nuclear translocation of p65 and the consequent phosphorylation.	Hydrogen	32-34	nuclear factor kappa B subunit 1	Homo sapiens	56-65
23022543-5	2013	After 1h of contact between the protein solution and the surface, the adsorbed insulin has practically stopped dissociating from the surface.	Hydrogen	6-8	insulin	Homo sapiens	79-86
23117207-7	2013	Keap1 is expressed in differentiating osteoclast-like cells and the S349T mutation selectively impairs the SQSTM1-Keap1 interaction in co-immunoprecipitations, which molecular modelling indicates results from effects on critical hydrogen bonds required to stabilise the KIR-Keap1 complex.	Hydrogen	229-237	kelch like ECH associated protein 1	Homo sapiens	0-5
23247143-3	2013	We sought to identify novel genetic variants that are associated with hs-cTnT levels.	Hydrogen	70-72	troponin T2, cardiac type	Homo sapiens	73-77
23155056-4	2013	The results demonstrate the importance of the N-terminal backbone structure and hydrogen-bonding pattern for the stability of alpha-lactalbumin.	Hydrogen	80-88	lactalbumin alpha	Homo sapiens	126-143
22897592-3	2013	The main cause of Akt inhibition is considered to be the strong hydrogen bond between N-H and Thr-291, and hydrophobic interactions at Glu-234, and Asp-292 in the vicinity, which is usually occupied by the ribose of ATP, and interaction with residue Phe-161, thus leading to a significant conformational change in that particular portion of the protein.	Hydrogen	64-72	AKT serine/threonine kinase 1	Homo sapiens	18-21
22920091-8	2013	Further analysis of pharmacophore model using PHASE module of Schrodinger revealed that two hydrogen bond acceptors (A), two hydrogen bond donors (D) and two hydrophobic aromatic rings (R) are crucial molecular features that predict binding affinity for meridianins to the Dyrk1A enzyme.	Hydrogen	92-100	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	273-279
22920091-8	2013	Further analysis of pharmacophore model using PHASE module of Schrodinger revealed that two hydrogen bond acceptors (A), two hydrogen bond donors (D) and two hydrophobic aromatic rings (R) are crucial molecular features that predict binding affinity for meridianins to the Dyrk1A enzyme.	Hydrogen	125-133	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	273-279
23256506-0	2013	Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics.	Hydrogen	109-117	phospholipase A2 group IB	Homo sapiens	46-62
23209293-0	2013	Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes.	Hydrogen	6-14	phospholipase A2 group IB	Homo sapiens	95-111
23209293-3	2013	Understanding how the different PLA(2) enzymes associate with phospholipid membranes, specific phospholipid substrate molecules, and inhibitors on a molecular basis has advanced in recent years due to the introduction of hydrogen/deuterium exchange mass spectrometry.	Hydrogen	221-229	phospholipase A2 group IB	Homo sapiens	32-38
22947217-4	2013	Our results show that 1h post-incubation, there was a 3-fold increase of extracellular H(2)O(2), increased intracellular oxidative stress as demonstrated by 2",7"-dichlorodihydrofluorescein diacetate (DCFH-DA) oxidation, and a 5-fold increase of phosphor-ERK1/2 as measured by Western blotting.	Hydrogen	22-24	mitogen-activated protein kinase 3	Homo sapiens	255-261
23146765-0	2013	1H NMR-based metabonomics approach in a rat model of acute liver injury and regeneration induced by CCl4 administration.	Hydrogen	0-2	C-C motif chemokine ligand 4	Rattus norvegicus	100-104
23311980-9	2013	Homology-based structural modelling shows that the variants can alter hydrogen bonding, salt bridging, or van der Waals interactions of amino acid side chains, locally or at one another"s sites which are distant in PEPCK"s structure, and thus may affect its enzyme function.	Hydrogen	70-78	Phosphoenolpyruvate carboxykinase 1	Drosophila melanogaster	215-220
23476386-3	2013	In the crystal, pi-pi stacking inter-actions [centroid-centroid distance = 3.5585 (15) A] connect mol-ecules into inversion dimers which are linked by Csp-H O=C hydrogen bonds, forming a ladder-like structure.	Hydrogen	161-169	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	151-154
23476440-7	2013	In the crystal, the bromide anion accepts a weak hydrogen bond from the N-H group of a neighboring 1,4-DHP ring.	Hydrogen	49-57	dihydropyrimidinase	Homo sapiens	103-106
23275167-8	2013	Additionally, the various hydrogen bonds formed between the AHNAK peptide and (p11)(2)(AnxA2)(2) most often involve backbone atoms of AHNAK; as a result, the side chains, particularly those that point away from S100A10/AnxA2 towards the solvent, are largely interchangeable.	Hydrogen	26-34	S100 calcium binding protein A10	Homo sapiens	79-82
23275167-8	2013	Additionally, the various hydrogen bonds formed between the AHNAK peptide and (p11)(2)(AnxA2)(2) most often involve backbone atoms of AHNAK; as a result, the side chains, particularly those that point away from S100A10/AnxA2 towards the solvent, are largely interchangeable.	Hydrogen	26-34	S100 calcium binding protein A10	Homo sapiens	211-218
23359864-2	2013	Heparan sulfatase 1 (HSulf-1) and heparan sulfatase 2 (HSulf-2) are two important 6-O endosulfatases which remove or edit 6-O sulfate residues of N-glucosamine present on highly sulfated HS.	Hydrogen	21-23	sulfatase 1	Homo sapiens	8-19
22851447-3	2013	This chapter describes the utilization of GAPDH"s enzymatic function for focal demands (i.e. ATP/ADP and NAD(+)/NADH), and offers a speculative role for GAPDH as perhaps moderating local concentrations of inorganic phosphate and hydrogen ions (i.e. co-substrate and co-product of the glycolytic reaction, respectively).	Hydrogen	229-237	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-47
23206863-4	2013	Formation of hydrogen bonds with Arg48 in Staphylococcus aureus TMK was key to obtaining excellent enzyme affinity, as verified by protein crystallography.	Hydrogen	13-21	deoxythymidylate kinase	Homo sapiens	64-67
24148794-9	2013	Moreover, H2 treatment dose-dependently attenuated the increased levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta, HMGB1), but further increased the level of anti-inflammatory cytokine IL-10 at 3 h, 6 h, 12 h and 24 h after LPS stimulation.	Hydrogen	10-12	tumor necrosis factor	Homo sapiens	103-112
22939897-0	2013	Practical method for PCB degradation using Pd/C-H2-Mg system.	Hydrogen	48-50	pyruvate carboxylase	Homo sapiens	21-24
23983797-4	2013	Serum TNF- alpha , IL-6, and IL-18 and histopathological score in the pancreas were reduced after hydrogen-rich saline treatment.	Hydrogen	98-106	tumor necrosis factor	Rattus norvegicus	6-16
23983797-4	2013	Serum TNF- alpha , IL-6, and IL-18 and histopathological score in the pancreas were reduced after hydrogen-rich saline treatment.	Hydrogen	98-106	interleukin 6	Rattus norvegicus	19-23
24008771-4	2013	Hydrogen-rich solution was reported to inhibit the levels of cytokines including INF-gamma, TNF-alpha and IL-6 in vivo in recent studies.	Hydrogen	0-8	interferon gamma	Mus musculus	81-90
24008771-4	2013	Hydrogen-rich solution was reported to inhibit the levels of cytokines including INF-gamma, TNF-alpha and IL-6 in vivo in recent studies.	Hydrogen	0-8	tumor necrosis factor	Mus musculus	92-101
24008771-4	2013	Hydrogen-rich solution was reported to inhibit the levels of cytokines including INF-gamma, TNF-alpha and IL-6 in vivo in recent studies.	Hydrogen	0-8	interleukin 6	Mus musculus	106-110
23983797-6	2013	The expression of mRNA of tumor necrosis factor- alpha (TNF- alpha ) and intercellular adhesion molecule-1 (ICAM-1) in the pancreas was reduced in hydrogen-rich saline treated group.	Hydrogen	147-155	tumor necrosis factor	Rattus norvegicus	26-54
23983797-6	2013	The expression of mRNA of tumor necrosis factor- alpha (TNF- alpha ) and intercellular adhesion molecule-1 (ICAM-1) in the pancreas was reduced in hydrogen-rich saline treated group.	Hydrogen	147-155	tumor necrosis factor	Rattus norvegicus	56-66
24148794-9	2013	Moreover, H2 treatment dose-dependently attenuated the increased levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta, HMGB1), but further increased the level of anti-inflammatory cytokine IL-10 at 3 h, 6 h, 12 h and 24 h after LPS stimulation.	Hydrogen	10-12	interleukin 1 beta	Homo sapiens	114-122
23559827-8	2013	After extensive and controlled in silico analysis it has been observed that the analogue LOPI1 binds to Nef protein (2NEF) at CD4 interacting site residues giving minimum binding energy of -7.68 Kcal/mole, low Ki value of 2.34 muM, maximum number of hydrogen bonds (8), good absorption, distribution, metabolism and excretion properties, and less toxicity in comparison with the standard Lopinavir against HIV1 protease (1HPV).	Hydrogen	250-258	CD4 molecule	Homo sapiens	126-129
23132686-9	2013	PVP K29/32 appeared to form stronger hydrogen bond interactions with resveratrol relative to HPMC, HPMCAS, and PAA, consistent with acceptor group chemistry.	Hydrogen	37-45	keratin 32	Homo sapiens	4-10
23614987-2	2013	The present study observed significantly increased expression of TNFa at either 1h or 24h of 5%FOR nociception, as well as sustained TNFa immunoreactivity in the IDLE.	Hydrogen	80-82	tumor necrosis factor	Homo sapiens	65-69
23212446-0	2013	Treatment with hydrogen molecule alleviates TNFalpha-induced cell injury in osteoblast.	Hydrogen	15-23	tumor necrosis factor	Rattus norvegicus	44-52
23212446-3	2013	In this study, we investigated the effect of treatment with hydrogen molecule (H(2)) on TNFalpha-induced cell injury in osteoblast.	Hydrogen	60-68	tumor necrosis factor	Rattus norvegicus	88-96
23212446-3	2013	In this study, we investigated the effect of treatment with hydrogen molecule (H(2)) on TNFalpha-induced cell injury in osteoblast.	Hydrogen	79-84	tumor necrosis factor	Rattus norvegicus	88-96
23212446-5	2013	It was found that TNFalpha suppressed cell viability, induced cell apoptosis, suppressed Runx2 mRNA expression, and inhibited alkaline phosphatase activity, which was reversed by co-incubation with H(2).	Hydrogen	198-202	tumor necrosis factor	Rattus norvegicus	18-26
23212446-5	2013	It was found that TNFalpha suppressed cell viability, induced cell apoptosis, suppressed Runx2 mRNA expression, and inhibited alkaline phosphatase activity, which was reversed by co-incubation with H(2).	Hydrogen	198-202	RUNX family transcription factor 2	Rattus norvegicus	89-94
23212446-6	2013	Incubation with TNFalpha-enhanced intracellular reactive oxygen species (ROS) formation and malondialdehyde production increased NADPH oxidase activity, impaired mitochondrial function marked by increased mitochondrial ROS formation and decreased mitochondrial membrane potential and ATP synthesis, and suppressed activities of antioxidant enzymes including SOD and catalase, which were restored by co-incubation with H(2).	Hydrogen	418-422	tumor necrosis factor	Rattus norvegicus	16-24
23212446-7	2013	Treatment with H(2) inhibited TNFalpha-induced activation of NFkappaB pathway.	Hydrogen	15-19	tumor necrosis factor	Rattus norvegicus	30-38
23212446-8	2013	In addition, treatment with H(2) inhibited TNFalpha-induced nitric oxide (NO) formation through inhibiting iNOS activity.	Hydrogen	28-32	tumor necrosis factor	Rattus norvegicus	43-51
23212446-8	2013	In addition, treatment with H(2) inhibited TNFalpha-induced nitric oxide (NO) formation through inhibiting iNOS activity.	Hydrogen	28-32	nitric oxide synthase 2	Rattus norvegicus	107-111
23212446-9	2013	Treatment with H(2) inhibited TNFalpha-induced IL-6 and ICAM-1 mRNA expression.	Hydrogen	15-19	tumor necrosis factor	Rattus norvegicus	30-38
23212446-9	2013	Treatment with H(2) inhibited TNFalpha-induced IL-6 and ICAM-1 mRNA expression.	Hydrogen	15-19	interleukin 6	Rattus norvegicus	47-51
23212446-10	2013	In conclusion, treatment with H(2) alleviates TNFalpha-induced cell injury in osteoblast through abating oxidative stress, preserving mitochondrial function, suppressing inflammation, and enhancing NO bioavailability.	Hydrogen	30-34	tumor necrosis factor	Rattus norvegicus	46-54
23276293-8	2013	Protein-protein docking investigation of P16-INK4 revealed four ionic bonds illustrating Arg47, Arg80,Cys72 and Met1 residues as actively participating in interactions with CDK4 while docking results of RB1 showed four hydrogen bonds involving Glu864, Ser567, Asp36 and Arg861 residues which interact strongly with its respective functional interactor E2F1.	Hydrogen	219-227	cyclin dependent kinase inhibitor 2A	Homo sapiens	41-49
23468841-9	2013	The unwinding of H2 can be related to the ability of Bcl-XL to bind diverse BH3 ligands.	Hydrogen	17-19	BCL2 like 1	Homo sapiens	53-59
23326534-4	2013	The results show that H(2) promoted 2-[(14)C]-deoxy-d-glucose (2-DG) uptake into C2C12 cells via the translocation of glucose transporter Glut4 through activation of phosphatidylinositol-3-OH kinase (PI3K), protein kinase C (PKC), and AMP-activated protein kinase (AMPK), although it did not stimulate the translocation of Glut2 in Hep G2 cells.	Hydrogen	22-26	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	138-143
23409238-1	2013	Here we employ hydrogen/deuterium exchange mass spectrometry (HDX-MS) to access E. coli chaperonin GroEL conformation.	Hydrogen	15-23	GroEL	Escherichia coli	99-104
23150718-8	2012	Notably, FcgammaRIIb-mediated inhibition of B6.K(d) heart graft rejection was abrogated by increasing T cell help through transfer of additional H2.K(d)-specific CD4 T cells.	Hydrogen	145-147	Fc receptor, IgG, low affinity IIb	Mus musculus	9-20
23436981-1	2012	Protein equilibrium snapshot by hydrogen/deuterium exchange electrospray ionization mass spectrometry (PEPS-HDX-ESI-MS or PEPS) is a method recently introduced for estimating protein folding energies and rates.	Hydrogen	32-40	leucine aminopeptidase 3	Homo sapiens	103-107
23439742-0	2012	Hydrogen/Deuterium Exchange Reflects Binding of Human Centrin 2 to Ca(2+) and Xeroderma Pigmentosum Group C Peptide: An Example of EX1 Kinetics.	Hydrogen	0-8	centrin 2	Homo sapiens	54-63
23093378-7	2012	Moreover, based on the difference in intermolecular distances distribution of water molecules (obtained from spectral data), we demonstrated that the lysozyme molecule causes a decrease in population of weak hydrogen bonds, and concurrently increases the probability of an occurrence of short hydrogen bonds in water affected by lysozyme.	Hydrogen	208-216	lysozyme	Homo sapiens	150-158
23061093-3	2012	Addition of fibrinogen to the CuInS(2) QDs solution led to the formation of a Fib-CuInS(2) QDs complex through electrostatic interactions and hydrogen bonding, and resulting in the enhancement of photoluminescence (PL) intensity and a red shift of the PL peak.	Hydrogen	142-150	fibrinogen beta chain	Homo sapiens	12-22
23061093-3	2012	Addition of fibrinogen to the CuInS(2) QDs solution led to the formation of a Fib-CuInS(2) QDs complex through electrostatic interactions and hydrogen bonding, and resulting in the enhancement of photoluminescence (PL) intensity and a red shift of the PL peak.	Hydrogen	142-150	fibrinogen beta chain	Homo sapiens	78-81
22983389-8	2012	These second-generation inhibitors are essentially a specific chemical moiety that helps to form a strong hydrogen bond interaction with the PI3K/Akt molecule.	Hydrogen	106-114	AKT serine/threonine kinase 1	Homo sapiens	146-149
23228056-12	2012	Docking observation of human recombinant cyclooxygenase-1 supported a role of the phenol group in the fitting of cyclooxygenase-1, most likely related to hydrogen bonding with the Tyr 355 of cyclooxygenase-1.	Hydrogen	154-162	prostaglandin-endoperoxide synthase 1	Homo sapiens	41-57
23228056-12	2012	Docking observation of human recombinant cyclooxygenase-1 supported a role of the phenol group in the fitting of cyclooxygenase-1, most likely related to hydrogen bonding with the Tyr 355 of cyclooxygenase-1.	Hydrogen	154-162	prostaglandin-endoperoxide synthase 1	Homo sapiens	113-129
23228056-12	2012	Docking observation of human recombinant cyclooxygenase-1 supported a role of the phenol group in the fitting of cyclooxygenase-1, most likely related to hydrogen bonding with the Tyr 355 of cyclooxygenase-1.	Hydrogen	154-162	prostaglandin-endoperoxide synthase 1	Homo sapiens	113-129
22871993-7	2012	In cultured melanocytes, subtoxic levels of H(2)O(2) (30-300 muM) significantly increased the IL-6 mRNA and protein levels in a dose-dependent manner.	Hydrogen	44-48	interleukin 6	Homo sapiens	94-98
22982814-10	2012	In contrast, the more energetically demanding hydrogen abstractions of the allylic carbons of 20:1n-6 by COX-1 and 18:1n-9 by 8R-DOX were both accompanied by large D-KIE (&gt;20).	Hydrogen	46-54	cox1	Glycine max	105-110
23093378-7	2012	Moreover, based on the difference in intermolecular distances distribution of water molecules (obtained from spectral data), we demonstrated that the lysozyme molecule causes a decrease in population of weak hydrogen bonds, and concurrently increases the probability of an occurrence of short hydrogen bonds in water affected by lysozyme.	Hydrogen	208-216	lysozyme	Homo sapiens	329-337
23093378-7	2012	Moreover, based on the difference in intermolecular distances distribution of water molecules (obtained from spectral data), we demonstrated that the lysozyme molecule causes a decrease in population of weak hydrogen bonds, and concurrently increases the probability of an occurrence of short hydrogen bonds in water affected by lysozyme.	Hydrogen	293-301	lysozyme	Homo sapiens	150-158
23093378-7	2012	Moreover, based on the difference in intermolecular distances distribution of water molecules (obtained from spectral data), we demonstrated that the lysozyme molecule causes a decrease in population of weak hydrogen bonds, and concurrently increases the probability of an occurrence of short hydrogen bonds in water affected by lysozyme.	Hydrogen	293-301	lysozyme	Homo sapiens	329-337
23062108-6	2012	Diffusion from this alternative adsorption state has a lower energy barrier of ~0.9 eV, associated with breaking hydrogen bonds along the pathway, in reasonable agreement with the barrier inferred from previous experimental observation of lysozyme surface clustering.	Hydrogen	113-121	lysozyme	Homo sapiens	239-247
23046248-3	2012	The nanomolar inhibitor 5 possessed good p53-MDM2 inhibitory activity (K(i) = 780 nM) due to its hydrophobic and hydrogen bonding interactions with MDM2.	Hydrogen	113-121	tumor protein p53	Homo sapiens	41-44
24688667-6	2012	By starting from the description of natural enzyme systems for plant biomass degradation and natural metabolic pathways for some of the most valuable product (i.e. butanol, ethanol, and hydrogen) biosynthesis, this review describes state-of-the-art bottlenecks and solutions for the development of recombinant microbial strains for cellulosic biofuel CBP by metabolic engineering.	Hydrogen	186-194	CREB binding protein	Homo sapiens	351-354
23066790-0	2012	Effects of the Iowa and Milano mutations on apolipoprotein A-I structure and dynamics determined by hydrogen exchange and mass spectrometry.	Hydrogen	100-108	apolipoprotein A1	Homo sapiens	44-62
23137500-10	2012	CONCLUSIONS: Elevated hs-cTnT is more common in the elderly due to higher prevalence of non-ACS conditions and significantly impairs diagnostic performance in discriminating non-ST-segment elevation myocardial infarction.	Hydrogen	22-24	troponin T2, cardiac type	Homo sapiens	25-29
22887912-1	2012	Small-angle neutron scattering (SANS) and diffusion NMR studies are performed to investigate the stability and geometry of hydrogen-bonded pyrene-guest-containing C-hexylpyrogallol[4]arene (PgC(6) -pyrene) nanotubular frameworks in solution.	Hydrogen	123-131	progastricsin	Homo sapiens	190-193
22887912-5	2012	Individual hydrogen-bonded spheres of PgC(6)  exhibits a uniform radius of ca.	Hydrogen	11-19	progastricsin	Homo sapiens	38-41
22940317-1	2012	Co-cultivation of Bradyrhizobium japonicum with Chlamydomonas reinhardtii strain cc849 or the transgenic strain lba, which was hetero-expressed the gene of the soybean leghemoglobin apoprotein Lba in chloroplasts of the strain cc849, in Tris-acetate-phosphate (TAP) or TAP-sulfur free media, improved H(2) yield.	Hydrogen	301-305	leghemoglobin A	Glycine max	112-115
22899366-5	2012	PDE4 fails to accommodate cGMP is correlated to the weakening of this same hydrogen-bond network but not owing to any steric strain in the binding pocket.	Hydrogen	75-83	phosphodiesterase 4A	Homo sapiens	0-4
22940317-2	2012	H(2) production was 14 times and growth was 26% higher when strain lba and B. japonicum were co-cultured, as compared with cultivation of the algal strain alone under the same conditions.	Hydrogen	0-4	leghemoglobin A	Glycine max	67-70
23021992-0	2012	Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1.	Hydrogen	35-43	superoxide dismutase 1	Homo sapiens	133-155
22824468-7	2012	Our in silico analysis suggested that S136A and P764L variants of BRAF could directly or indirectly destabilize the amino acid interactions and hydrogen bond networks thus explain the functional deviations of protein to some extent.	Hydrogen	144-152	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	66-70
21515038-4	2012	Further, MCE administration 1h prior to graded doses of K(2)Cr(2)O(7) significantly decreased reactive oxygen species (ROS) level, increased the mitochondrial membrane potential, reduced apoptosis and caspase 3 activity.	Hydrogen	28-30	caspase 3	Homo sapiens	201-210
23061476-2	2012	Glycine (and glycine-N,N,O-d(3)) ttc/VIp was found to convert back to ttt/Ip in the dark by hydrogen-atom tunneling.	Hydrogen	92-100	vasoactive intestinal peptide	Homo sapiens	37-40
22962365-8	2012	TDG allows hydrogen-bonding interactions to both T/U-based (5hmU) and C-based (5caC) modifications, thus enabling its activity on a wider range of substrates.	Hydrogen	11-19	thymine DNA glycosylase	Homo sapiens	0-3
22835504-14	2012	Molecular modeling and dynamics results suggest that the rearrangement of the hydrogen-bonding network near the E43G mutation could explain the improved functional stability and neutralization properties of both the diabody D4 and scFv LER.	Hydrogen	78-86	immunglobulin heavy chain variable region	Homo sapiens	231-235
22992044-1	2012	Experiments in recent years have shown that there is a large kinetic isotope effect in the rate of transfer of hydrogen or deuterium in enzymatic reactions of soybean lipoxygenase-1.	Hydrogen	111-119	seed linoleate 13S-lipoxygenase-1	Glycine max	167-181
22992513-7	2012	We show that MED25-BINDING RING-H2 PROTEIN1 (MBR1) and MBR2 bind to PFT1 in yeast (Saccharomyces cerevisiae) and in vitro, and they promote PFT1 degradation in vivo, in a RING-H2-dependent way, typical of E3 ubiquitin ligases.	Hydrogen	32-34	phytochrome and flowering time regulatory protein (PFT1)	Arabidopsis thaliana	13-18
22992513-7	2012	We show that MED25-BINDING RING-H2 PROTEIN1 (MBR1) and MBR2 bind to PFT1 in yeast (Saccharomyces cerevisiae) and in vitro, and they promote PFT1 degradation in vivo, in a RING-H2-dependent way, typical of E3 ubiquitin ligases.	Hydrogen	32-34	phytochrome and flowering time regulatory protein (PFT1)	Arabidopsis thaliana	68-72
22992513-7	2012	We show that MED25-BINDING RING-H2 PROTEIN1 (MBR1) and MBR2 bind to PFT1 in yeast (Saccharomyces cerevisiae) and in vitro, and they promote PFT1 degradation in vivo, in a RING-H2-dependent way, typical of E3 ubiquitin ligases.	Hydrogen	32-34	phytochrome and flowering time regulatory protein (PFT1)	Arabidopsis thaliana	140-144
23387084-8	2012	The results of molecular modeling revealed that hydrophobic and hydrogen bonds are main binding forces in the PM-Tf system.	Hydrogen	64-72	transferrin	Homo sapiens	113-115
22985023-7	2012	Moreover, (1)H and (19)F-NMR studies show that this pi-pi interaction promotes hydrogen transfer from [(NHC)AuH] to pyridyl N atom, resulting in C-F bond cleavage.	Hydrogen	79-87	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	108-111
22521290-7	2012	KEY FINDINGS: Constrictor responses to phenylephrine (PE) and ET-1 were increased in vessels treated for 1h with chemerin.	Hydrogen	105-107	endothelin 1	Rattus norvegicus	62-66
23351427-3	2012	Our purpose is to study the prophylactic effect of HS 5% infusion versus NS on serum IL-6 as an inflammatory &amp; IL-10 as an anti-inflammatory biomarker in CABG patients.	Hydrogen	51-53	interleukin 6	Homo sapiens	85-89
23066313-6	2012	ALT and AST in Hydrogen-group was significantly lower comparing to contrast-group (P = 0.036, P = 0.011, vs. P = 0.032, P = 0.013) at PH 1 h and 3 h, although the two groups all increased.	Hydrogen	15-23	AST	Sus scrofa	8-11
23316300-8	2012	H(2) gas inhalation, but not TH, prevented a rise in left ventricular end-diastolic pressure and increase in serum IL-6 level after ROSC.	Hydrogen	0-4	interleukin 6	Rattus norvegicus	115-119
21898049-0	2012	1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 31 kDa human galectin-7 (p53-induced gene 1) homodimer, a pro-apoptotic lectin.	Hydrogen	0-2	galectin 7	Homo sapiens	89-99
21898049-0	2012	1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 31 kDa human galectin-7 (p53-induced gene 1) homodimer, a pro-apoptotic lectin.	Hydrogen	0-2	tumor protein p53	Homo sapiens	101-104
22290676-0	2012	1H, 13C, and 15N resonance assignments of the N-terminal domain of human TIG3.	Hydrogen	0-2	phospholipase A and acyltransferase 4	Homo sapiens	73-77
22311340-0	2012	1H, 13C and 15N backbone and side chain resonance assignments of human halo S100A1.	Hydrogen	0-2	S100 calcium binding protein A1	Homo sapiens	76-82
22446688-9	2012	To understand the differences in substrate conversion, we constructed a new homology model based on the 3D structure of CYP11A1, performed docking studies and calculated the activation energy for hydrogen abstraction of the different ligands.	Hydrogen	196-204	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	120-127
22861526-10	2012	Finally, analysis of ATR/FTIR spectra revealed that, with increasing water content, the average hydrogen-bond enthalpy of the fructose hydroxyls decreases by ~2.5 kJ/mol.	Hydrogen	96-104	ATR serine/threonine kinase	Homo sapiens	21-24
22892866-0	2012	Au/Ag-Mo nano-rods catalyzed reductive coupling of nitrobenzenes and alcohols using glycerol as the hydrogen source.	Hydrogen	100-108	alkylglycerol monooxygenase	Homo sapiens	3-8
22892866-1	2012	A highly efficient Au/Ag-Mo nano-rods catalyst was prepared for the one-pot synthesis of imine and amine using equal molar ratio of nitrobenzene and alcohol as starting materials, and bio-based glycerol as the hydrogen source.	Hydrogen	210-218	alkylglycerol monooxygenase	Homo sapiens	22-27
22924492-6	2012	Hydrogen-bonding and electrostatic interactions of the silanol surfaces of fumed silica aggregates with the extracellular plasma membrane cause membrane perturbations sensed by the Nalp3 inflammasome, whose subsequent activation leads to secretion of the cytokine IL-1beta.	Hydrogen	0-8	NLR family pyrin domain containing 3	Homo sapiens	181-186
22924492-6	2012	Hydrogen-bonding and electrostatic interactions of the silanol surfaces of fumed silica aggregates with the extracellular plasma membrane cause membrane perturbations sensed by the Nalp3 inflammasome, whose subsequent activation leads to secretion of the cytokine IL-1beta.	Hydrogen	0-8	interleukin 1 beta	Homo sapiens	264-272
22921743-8	2012	Two inhibitors are benzimidazole-like compounds that reversibly and competitively inhibit human DDAH-1 with Ligand Efficiency values &gt;=0.3 kcal/mol/heavy (non-hydrogen) atom, indicating their suitability for further development.	Hydrogen	162-170	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	96-102
22894179-8	2012	This stems from the hydrogen bonds (HBs) that lysozyme and trehalose form with water, which, interestingly, are stronger than the ones they form with each other but which, nonetheless, relax faster on the ns time scale, given the larger mobility of water.	Hydrogen	20-28	lysozyme	Homo sapiens	46-54
22542687-3	2012	Vibrational spectra (ATR and Raman) clearly indicated hydrogen bonding of the studied hydrazones through the carbonyl, amino and hydroxyl groups with water molecules.	Hydrogen	54-62	ATR serine/threonine kinase	Homo sapiens	21-24
22836697-2	2012	BLP-2(H) crystallizes into 2D sheets that stack in an eclipsed AA fashion, has high thermal stability (~420  C) and high porosity (SA(BET) = 1178 m(2) g(-1)) and it can store up to 2.4 wt% of hydrogen at 77 K and 15 bar with isosteric heat of adsorption of 6.8 kJ mol(-1).	Hydrogen	192-200	TM2 domain containing 3	Homo sapiens	0-5
22902635-8	2012	Hydrogen treatment also induced the transcription factors C/EBPalpha and C/EBPbeta, which are known regulators of surfactant-related genes.	Hydrogen	0-8	CCAAT enhancer binding protein alpha	Homo sapiens	58-68
22798378-5	2012	The predicted binding mode of 4HPR with mTOR was based on a homology computer model, which showed that 4HPR could bind in the ATP-binding pocket of the mTOR protein through hydrogen bonds and hydrophobic interactions.	Hydrogen	173-181	mechanistic target of rapamycin kinase	Homo sapiens	40-44
22798378-5	2012	The predicted binding mode of 4HPR with mTOR was based on a homology computer model, which showed that 4HPR could bind in the ATP-binding pocket of the mTOR protein through hydrogen bonds and hydrophobic interactions.	Hydrogen	173-181	mechanistic target of rapamycin kinase	Homo sapiens	152-156
23106052-8	2012	Ratios of T/NT of (18)F-FLT PET  (0.5h, 5.39+-0.42; 1h, 4.88+-0.43; 2h, 3.81+-0.38) were higher than those of (18)F-FDG PET/CT  (0.5h, 0.34+-0.12; 1h, 0.21+-0.06; 2h, 0.13+-0.05) after injection.	Hydrogen	147-149	fms related receptor tyrosine kinase 1	Homo sapiens	24-27
22921971-10	2012	The AUC for BNP and hs-cTnT together was 0.81 and 0.82 in men.	Hydrogen	20-22	troponin T2, cardiac type	Homo sapiens	23-27
24273448-4	2012	The formation, structure, and isomerization of fac-Re(CO)3(ASMA) products were characterized by HPLC, 1H NMR spectroscopy, and X-ray crystallography.	Hydrogen	102-104	FA complementation group C	Homo sapiens	47-50
22486613-6	2012	The inhibitor exhibits extensive interactions with the EGFR catalytic site in the form of hydrogen bonds, pi-pi bond and salt bridges.	Hydrogen	90-98	epidermal growth factor receptor	Homo sapiens	55-59
22920129-0	2012	Structural changes of filled ice Ic hydrogen hydrate under low temperatures and high pressures from 5 to 50 GPa.	Hydrogen	36-44	glycophorin A (MNS blood group)	Homo sapiens	108-111
22641618-9	2012	Subsequent structure and activity relationship studies with analogs of this derivative indicated that an appropriate distance between hydrogen bond acceptor features and presence of one or two negative charges appear critical for a successful NTCP interaction.	Hydrogen	134-142	solute carrier family 10 member 1	Homo sapiens	243-247
23227542-7	2012	Icariin binds selectively to the AChE peripheral anionic site via hydrogen bonds and Van der Waals forces.	Hydrogen	66-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	33-37
22733119-6	2012	A cocrystal structure of one metallo-phthalimide with the protein kinase Pim1 confirmed an ATP-competitive binding with the intended hydrogen bonding between the phthalimide moiety and the hinge region of the ATP-binding site.	Hydrogen	133-141	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	73-77
22838384-4	2012	The method is applied to probe the effect of the active site elements on the critical hydrogen transfer step in the soybean lipoxygenase-1 (SLO-1) catalyzed oxidation of linoleic acid.	Hydrogen	86-94	seed linoleate 13S-lipoxygenase-1	Glycine max	124-138
24900387-2	2012	The synthesis of a single derivative (compound 7) of the hit identified in silico has resulted in an improvement of the inhibitory potency in an enzymatic assay from 8.4 muM to 160 nM and a ligand efficiency of 0.39 kcal/mol per non-hydrogen atom.	Hydrogen	233-241	latexin	Homo sapiens	170-173
24900387-3	2012	Such remarkable improvement in affinity is due to an additional hydroxyl group involved in two favorable (buried) hydrogen bonds as predicted by molecular dynamics and validated by the crystal structure of the complex with EphA3 solved at 1.7 A resolution.	Hydrogen	114-122	EPH receptor A3	Homo sapiens	223-228
22355012-9	2012	Analysis in silico predicted that N496F, Y500F, or L504T would perturb hydrogen bonding in the heme pocket of MPO and thus disrupt the structural integrity of the enzyme.	Hydrogen	71-79	myeloperoxidase	Homo sapiens	110-113
22609246-7	2012	We found that rIL-10, when given concurrently or 1h after LPS, strongly inhibited LPS-induced TF procoagulant activity in canine PBMC and monocytes.	Hydrogen	49-51	coagulation factor III, tissue factor	Canis lupus familiaris	94-96
22904741-2	2012	There are several hydrogen-bonding inter-actions, the most significant of which is a hydrogen bond between the amide moiety of the NHC and the chloride ligand.	Hydrogen	18-26	high mobility group nucleosomal binding domain 4	Homo sapiens	131-134
22904741-2	2012	There are several hydrogen-bonding inter-actions, the most significant of which is a hydrogen bond between the amide moiety of the NHC and the chloride ligand.	Hydrogen	85-93	high mobility group nucleosomal binding domain 4	Homo sapiens	131-134
22766127-2	2012	In the crystal structure, H(3)L adopting a transoid conformation occurs as a neutral molecule linked with a water molecule by an intermolecular hydrogen bond.	Hydrogen	144-152	H3 clustered histone 2	Homo sapiens	26-31
22513143-10	2012	Important hydrogen bonding interactions between sorafenib and amino acids Ser-119 and Glu-374 in the active center of CYP3A4 were identified.	Hydrogen	10-18	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	118-124
22931625-7	2012	RESULTS: Hydrogen inhalation decreased the expression of p-p38 MAPK in the lung tissue, and significantly reduced TNF-alpha content in the lung tissue and serum of rats with ALI.	Hydrogen	9-17	tumor necrosis factor	Rattus norvegicus	114-123
22931625-8	2012	CONCLUSION: Hydrogen inhalation can decrease the expression of TNF-alpha in the lung tissue and serum, and this effect may be related with reduced p38 MAPK expression and inhibition of p38 MAPK activation.	Hydrogen	12-20	tumor necrosis factor	Rattus norvegicus	63-72
22716165-7	2012	Increased TNFalpha and IL-6 mRNA in the IRI livers was significantly attenuated by H2 S treatment, as was hepatic influx of Ly-6G positive granulocytes.	Hydrogen	83-85	tumor necrosis factor	Mus musculus	10-18
22716165-7	2012	Increased TNFalpha and IL-6 mRNA in the IRI livers was significantly attenuated by H2 S treatment, as was hepatic influx of Ly-6G positive granulocytes.	Hydrogen	83-85	interleukin 6	Mus musculus	23-27
22746312-7	2012	Moreover, hydrogen/deuterium exchange (H/DX) combined with FTICR MS provides the sensitive method to insight the small conformation change of cytochrome c induced by cisplatin.	Hydrogen	10-18	cytochrome c, somatic	Homo sapiens	142-154
22716019-2	2012	Previous studies have established that unnatural amino acid mutagenesis can probe three key binding interactions at the nAChR: a cation-pi interaction, and two hydrogen-bonding interactions to the protein backbone of the receptor.	Hydrogen	160-168	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	120-125
22745166-0	2012	Apolipoprotein A-I helical structure and stability in discoidal high-density lipoprotein (HDL) particles by hydrogen exchange and mass spectrometry.	Hydrogen	108-116	apolipoprotein A1	Homo sapiens	0-18
22554771-8	2012	Omentin (300ng/ml, 30min) inhibited TNF-alpha (1h)-induced nicotinamide adenine dinucleotide phosphate oxidase activity as determined by lucigenin assay.	Hydrogen	47-49	tumor necrosis factor	Rattus norvegicus	36-45
22583949-11	2012	Administration of NRG-1 at 1h after DFP injection similarly provided significant neuroprotection against delayed neuronal injury.	Hydrogen	27-29	neuregulin 1	Rattus norvegicus	18-23
22234530-0	2012	Modification of the secondary structure of angiotensin II by substitution of hydrogen with Cs cations: an experimental and theoretical study.	Hydrogen	77-85	angiotensinogen	Homo sapiens	43-57
22610090-0	2012	Design, synthesis and binding studies of a novel quadruple ADDA hydrogen-bond array.	Hydrogen	64-72	adducin 1	Homo sapiens	59-63
22610090-1	2012	The design and synthesis of a novel ADDA hydrogen-bond array is described.	Hydrogen	41-49	adducin 1	Homo sapiens	36-40
25683411-6	2012	In this process, calcium favoured the development of beta-sheet structures to form SPI aggregates stabilised by hydrogen bonding.	Hydrogen	112-120	chromogranin A	Homo sapiens	83-86
22651225-7	2012	RESULTS: Mean age at inclusion was 71.5 years, mean FEV1/FVC was 45%, and median hs-cTnT was 27.0 ng/L.	Hydrogen	81-83	troponin T2, cardiac type	Homo sapiens	84-88
22639394-5	2012	The orthogonal binding of the two hydrogen-bonding pairs was elucidated by chemical induced shift NMR titrations, which proved that the two pairs, isocyanuric acid with the Hamilton receptor and ADDA with DAAD, bind preferentially.	Hydrogen	34-42	adducin 1	Homo sapiens	195-199
22613228-13	2012	All VGF changes found using SL rats disappeared after only 1h of rehydration.	Hydrogen	59-61	VGF nerve growth factor inducible	Rattus norvegicus	4-7
22039821-5	2012	The optimized pharmacophore model derived from 20 substrates of CYP2D6 contained two hydrophobic features and one hydrogen bond acceptor feature, giving a relevance ratio of 76% when a validation set of substrates were tested.	Hydrogen	114-122	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	64-70
22039821-8	2012	Forty one out of 117 substrates (35.04%) formed hydrogen bonds with various active site residues of CYP2D6 and 53 (45.30%) substrates formed a strong pi-pi interaction with Phe120 (53/54), with only carvedilol showing pi-pi interaction with Phe483.	Hydrogen	48-56	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	100-106
22039821-14	2012	Fifty four out of these 60 compounds could be docked into the active site of CYP2D6 and 24 of 54 compounds formed hydrogen bonds with Glu216, Asp301, Ser304, and Ala305 in CYP2D6.	Hydrogen	114-122	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	77-83
22039821-14	2012	Fifty four out of these 60 compounds could be docked into the active site of CYP2D6 and 24 of 54 compounds formed hydrogen bonds with Glu216, Asp301, Ser304, and Ala305 in CYP2D6.	Hydrogen	114-122	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	172-178
22357520-2	2012	To understand how telmisartan partially activates PPARgamma, we determined the ternary complex structure of PPARgamma, telmisartan, and a coactivator peptide from steroid receptor coactivator-1 at a resolution of 2.18 A. Crystallographic analysis revealed that telmisartan exhibits an unexpected binding mode in which the central benzimidazole ring is engaged in a non-canonical--and suboptimal--hydrogen-bonding network around helix 12 (H12).	Hydrogen	396-404	peroxisome proliferator activated receptor gamma	Homo sapiens	108-117
22357520-3	2012	This network differs greatly from that observed when full-agonists bind with PPARgamma and prompt high-coactivator recruitment through H12 stabilized by multiple hydrogen bonds.	Hydrogen	162-170	peroxisome proliferator activated receptor gamma	Homo sapiens	77-86
22246285-4	2012	(ii) Molecular docking and molecular dynamics simulations experiments of the inhibitors into the binding site of CHK(1) aided the interpretation of the QSAR models and demonstrated the binding modes in the aspects of inhibitor"s conformation, subsite interaction, and hydrogen bonding interactions, which indicated that a set of critical residues (Cys87, Glu91, Glu85, Ser147, Asp148, Glu17, Leu84 and Asn135) played a key role in the drug-target interactions.	Hydrogen	268-276	checkpoint kinase 1	Homo sapiens	113-119
22503158-3	2012	From molecular docking analysis, hydrogen bonding as well as hydrophobic and pi interactions were found between PAHs and ERalpha.	Hydrogen	33-41	estrogen receptor 1	Homo sapiens	121-128
22587454-9	2012	Hydrophobic packing of side chains was responsible for enhanced beta-hairpin lifetimes in the Dutch and Iowa mutants, whereas lifetimes in Abeta(21-30) and its Arctic mutant were influenced by the backbone hydrogen bonding.	Hydrogen	206-214	amyloid beta precursor protein	Homo sapiens	139-144
22359158-5	2012	Studies showed that hydrogen bonding and electrostatic interactions between drug and moringa coagulant are responsible for amorphous state stabilization as explored by ATR-FTIR and molecular docking.	Hydrogen	20-28	ATR serine/threonine kinase	Homo sapiens	168-171
22852716-1	2012	The failure of hydrogen sensor with palladium film is primarily the phase transition of PdH.	Hydrogen	15-23	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	88-91
22556416-8	2012	These data highlight the importance of hydrogen bonding on the receptor-ligand state, and suggest that it may be possible to fine-tune features of agonists that mediate state selection in the nAChR.	Hydrogen	39-47	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	192-197
21987406-11	2012	Differences in the expression of HS epitopes between control and IL10(-/-) mice were also confirmed.	Hydrogen	33-35	interleukin 10	Mus musculus	65-69
22407542-7	2012	These results suggest that a positive charge at position 562 destabilizes the hydrogen-bond-mediated NOS/CaM alignment, resulting in slower FMN-heme IET in the mutant.	Hydrogen	78-86	calmodulin 3	Homo sapiens	105-108
22517776-4	2012	Mutated arginine makes hPTH" fill the receptor cavity better as well as forms hydrogen bonds with Val193.	Hydrogen	78-86	parathyroid hormone	Homo sapiens	23-28
22585969-6	2012	A minimal computational model accounting for the kinetics of GSH/Trx systems was developed and was able to simulate increase in H(2)O(2) emission fluxes when both scavenging systems were inhibited separately or together.	Hydrogen	128-132	thioredoxin 1	Rattus norvegicus	65-68
22083165-4	2012	In the simulated structures, the hydrophilic W(1), W(2) and WD(1) centers form hydrogen bonds with the OD1 atom of Asp158 and the ND1 atom of His159.	Hydrogen	79-87	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	130-133
22083165-9	2012	A few dynamical conformations or transition states involving direct (His159 ND1...Asp158 OD1) and water-mediated (His159 ND1...W(2)...Asp158 OD1) hydrogen-bonded complexes are envisaged from these studies.	Hydrogen	146-154	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	76-79
22083165-9	2012	A few dynamical conformations or transition states involving direct (His159 ND1...Asp158 OD1) and water-mediated (His159 ND1...W(2)...Asp158 OD1) hydrogen-bonded complexes are envisaged from these studies.	Hydrogen	146-154	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	121-124
22153840-1	2012	Hydrogen (dihydrogen; H(2)) has an antiatherosclerotic effect in apolipoprotein (apo) E knockout mice.	Hydrogen	0-8	apolipoprotein E	Mus musculus	65-87
22153840-1	2012	Hydrogen (dihydrogen; H(2)) has an antiatherosclerotic effect in apolipoprotein (apo) E knockout mice.	Hydrogen	10-20	apolipoprotein E	Mus musculus	65-87
22153840-1	2012	Hydrogen (dihydrogen; H(2)) has an antiatherosclerotic effect in apolipoprotein (apo) E knockout mice.	Hydrogen	22-26	apolipoprotein E	Mus musculus	65-87
22522008-6	2012	Docking also indicated that the presence of a substituent capable of hydrogen bonding to the His194 residue is important in influencing the orientation of the substrate in the NQO1 active site, leading to more efficient reduction.	Hydrogen	69-77	NAD(P)H quinone dehydrogenase 1	Homo sapiens	176-180
22648259-5	2012	It was also reported that hydrogen could suppress the levels of TNF-alpha and IL-6.	Hydrogen	26-34	tumor necrosis factor	Homo sapiens	64-73
22648259-5	2012	It was also reported that hydrogen could suppress the levels of TNF-alpha and IL-6.	Hydrogen	26-34	interleukin 6	Homo sapiens	78-82
22427516-7	2012	Moreover, the increased levels of iNOS, nitrotyrosine, Toll-like receptor-4, BNP, PTX3, and TBARS in the HS group were inhibited by RHT.	Hydrogen	105-107	toll-like receptor 4	Rattus norvegicus	40-75
22427516-7	2012	Moreover, the increased levels of iNOS, nitrotyrosine, Toll-like receptor-4, BNP, PTX3, and TBARS in the HS group were inhibited by RHT.	Hydrogen	105-107	natriuretic peptide B	Rattus norvegicus	77-80
22590071-3	2012	In the crystal, the components are linked by O-H O, N-H O, N-H S, and O-H S hydrogen bonds.	Hydrogen	76-84	NHS actin remodeling regulator	Homo sapiens	45-73
22427660-4	2012	Here, we report the solution structure of CDK2AP1 by combined methods of solution state NMR and amide hydrogen/deuterium exchange measurements with mass spectrometry.	Hydrogen	102-110	cyclin dependent kinase 2 associated protein 1	Homo sapiens	42-49
22293581-5	2012	The PRP treated was impregnated into gelatin hydrogel granules freeze-dried at 37 C for 1h, and then the percentage of PGFM desorbed from the gelatin hydrogel granules was evaluated.	Hydrogen	88-90	proline rich protein HaeIII subfamily 1	Mus musculus	4-7
22418695-5	2012	The calculations at all-electron CCSD(T)/CBS level of theory indicate that the barriers for all reactions (forward and reverse) are greater than 100 kJ mol(-1), meaning that the chemical reactivity of the reactants is limited in the absence of hydrogen tunnelling.	Hydrogen	244-252	cystathionine beta-synthase	Homo sapiens	41-44
22366186-1	2012	Regulation of intracellular pH (pHi) and protection against cytosolic acidification is primarily a function of the ubiquitous plasma membrane Na+/H+exchanger-1 (NHE1), which uses a highly conserved process to transfer cytosolic hydrogen ions (H+) across plasma membranes in exchange for extracellular sodium ions (Na+).	Hydrogen	228-236	solute carrier family 9 member A1	Homo sapiens	142-159
22366186-1	2012	Regulation of intracellular pH (pHi) and protection against cytosolic acidification is primarily a function of the ubiquitous plasma membrane Na+/H+exchanger-1 (NHE1), which uses a highly conserved process to transfer cytosolic hydrogen ions (H+) across plasma membranes in exchange for extracellular sodium ions (Na+).	Hydrogen	228-236	solute carrier family 9 member A1	Homo sapiens	161-165
22387072-3	2012	We explored the conformational and structural dynamics of CaM using amide hydrogen-deuterium (H-D) exchange coupled with Fourier transform infrared (FT-IR) spectroscopy.	Hydrogen	74-82	calmodulin 1	Homo sapiens	58-61
22228035-3	2012	This study correlates the p38 MAP kinase inhibitory activities of 80 biphenyl amide derivatives to several stereochemical parameters representing steric, electrostatic, hydrophobic, hydrogen bond donor and acceptor fields.	Hydrogen	182-190	mitogen-activated protein kinase 14	Homo sapiens	26-29
22160573-4	2012	The results of thermodynamic parameters DeltaG, DeltaH, and DeltaS indicated that hydrogen bonds and van der Waals forces played major roles for HCPT-HSA association.	Hydrogen	82-90	albumin	Homo sapiens	150-153
22450432-5	2012	Bond valence calculations have been used to estimate the relative stabilities of the six hydrogen bonded networks, suggesting that the stretching of the Co(II) coordination sphere 4 in is assisted by adoption of the most stable hydrogen bonded network; but that in 6 this is overcome by a higher loading of Co.	Hydrogen	89-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
22450432-5	2012	Bond valence calculations have been used to estimate the relative stabilities of the six hydrogen bonded networks, suggesting that the stretching of the Co(II) coordination sphere 4 in is assisted by adoption of the most stable hydrogen bonded network; but that in 6 this is overcome by a higher loading of Co.	Hydrogen	228-236	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158
22414612-7	2012	The binding mode of 1 from docking simulation in the EGFR active site revealed that the urea motif formed hydrogen bonding with Lys745, Thr854 and Asp855 in hydrophobic pocket of EGFR.	Hydrogen	106-114	epidermal growth factor receptor	Homo sapiens	53-57
22416024-3	2012	The present studies demonstrate that (Me)OH is readily oxidised by an intramolecular PET mechanism to form the hydrogen-bonded phenoxyl-N-methylbenzimidazolium system ((Me)OH)(.+) , whereas oxidation of (pMe)OH occurs by intermolecular PET, affording the neutral phenoxyl benzimidazole ((pMe)O)(.)	Hydrogen	111-119	cystatin B	Homo sapiens	204-207
22416024-3	2012	The present studies demonstrate that (Me)OH is readily oxidised by an intramolecular PET mechanism to form the hydrogen-bonded phenoxyl-N-methylbenzimidazolium system ((Me)OH)(.+) , whereas oxidation of (pMe)OH occurs by intermolecular PET, affording the neutral phenoxyl benzimidazole ((pMe)O)(.)	Hydrogen	111-119	cystatin B	Homo sapiens	288-291
22416024-5	2012	The deprotonations of (Me)OH and (pMe)OH yield the corresponding phenolate species ((Me)O)(-) and ((pMe)O)(-), respectively, whilst that of the previously reported (H)OH (analogous to (Me)OH but lacking the N-methyl group) produces an unprecedented hydrogen-bonded phenol benzimidazolate species, as evidenced by its X-ray structure.	Hydrogen	249-257	cystatin B	Homo sapiens	34-37
22416024-5	2012	The deprotonations of (Me)OH and (pMe)OH yield the corresponding phenolate species ((Me)O)(-) and ((pMe)O)(-), respectively, whilst that of the previously reported (H)OH (analogous to (Me)OH but lacking the N-methyl group) produces an unprecedented hydrogen-bonded phenol benzimidazolate species, as evidenced by its X-ray structure.	Hydrogen	249-257	cystatin B	Homo sapiens	100-103
22414612-7	2012	The binding mode of 1 from docking simulation in the EGFR active site revealed that the urea motif formed hydrogen bonding with Lys745, Thr854 and Asp855 in hydrophobic pocket of EGFR.	Hydrogen	106-114	epidermal growth factor receptor	Homo sapiens	179-183
22352990-0	2012	Localized hydration in lyophilized myoglobin by hydrogen-deuterium exchange mass spectrometry.	Hydrogen	48-56	myoglobin	Equus caballus	35-44
22326845-5	2012	The whole process, from sample preparation to final read-out, is expected to take less than 1h and requires only a standard plate-reader, thus making the sensor a convenient and cost-effective tool for albumin analysis.	Hydrogen	92-94	albumin	Homo sapiens	202-209
22274589-4	2012	The analyses of Natural Bond Orbital and interaction energy using the B3LYP and MP2 (fc) methods suggested that the solubilization mechanism of microemulsion for naproxen mainly might be the formation of complex between the hydrogen atom of hydroxyl in Tween 80 and the oxygen atom of carbonyl group in naproxen, as is in accordance with the result from (1)H NMR experiments.	Hydrogen	224-232	proline rich protein HaeIII subfamily 1	Mus musculus	80-83
22289254-5	2012	To explain the adsorption enhancement of CTF, several specific, non-hydrophobic mechanisms were proposed, including hydrogen bonding (hydroxyl- and amino-substituted compounds), electrostatic attraction (anionized compounds), and pi-pi electron-donor-acceptor (EDA) interaction (nitroaromatic compounds) with the triazine structure of CTF.	Hydrogen	116-124	nuclear factor I C	Homo sapiens	41-44
22301678-8	2012	The former Co(II) complexes revealed a six-coordinate octahedron with one amine nitrogen, three pyridyl nitrogens, and two counter anions, and one coordinated anion, Cl(-), Br(-) and N(3)(-), forming intramolecular hydrogen bonds with two pivalamide N-H groups.	Hydrogen	215-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-17
22502547-8	2012	In the electrostatic interactions, the overwhelming majority of hydrogen bonds involve the main chains of Abeta as well as the guanidinium group of the charged side chain of Lys28.	Hydrogen	64-72	amyloid beta precursor protein	Homo sapiens	106-111
22392585-1	2012	The complex [Tp(Me2)Ir(C(6)H(5))(2)(N(2))] reacts with several 2-substituted pyridines to generate N-heterocyclic carbenes resulting from a formal 1,2-hydrogen shift from C(6) to N. In this paper we provide a detailed report of the scope and the mechanistic aspects (both experimental and theoretical) of the tautomerisation of 2-substituted pyridines.	Hydrogen	151-159	malic enzyme 2	Homo sapiens	16-19
22589841-5	2012	Strongly tight, via one intra-molecular hydrogen bond between aqua and carboxyl-ate O atoms, it brings out a quasi-planar six-membered ring around the Co(II) atom, turning the CoN(3)O(3) coordination octa-hedron into a new building block.	Hydrogen	40-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-157
22589841-7	2012	In the resulting supra-molecular packing, a binuclear hydrated Co(II) assembly, built up from triple strands driven by different heterosynthons, embodies the synergy of coordination, covalent and hydrogen bonds.	Hydrogen	196-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
21901408-0	2012	1H, 13C, and 15N NMR resonance assignments of reduced full length and shortened forms of the Grx domain of Mus musculus TGR.	Hydrogen	0-2	thioredoxin reductase 3	Mus musculus	120-123
22234331-10	2012	Computer modeling also revealed the differential binding is due to the chiral center of 20(S)-Rg3 can form a critical hydrogen bond with Tyr473 of PPARgamma ligand binding domain.	Hydrogen	118-126	peroxisome proliferator activated receptor gamma	Homo sapiens	147-156
21818549-0	2012	1H, 13C and 15N chemical shift assignments for the human Pitx2 homeodomain in complex with a 22-base hairpin DNA.	Hydrogen	0-2	paired like homeodomain 2	Homo sapiens	57-62
21643835-0	2012	1H, 15N and 13C assignments of an intramolecular LMO4-LIM1/CtIP complex.	Hydrogen	0-2	LIM homeobox 1	Homo sapiens	54-58
21643835-0	2012	1H, 15N and 13C assignments of an intramolecular LMO4-LIM1/CtIP complex.	Hydrogen	0-2	RB binding protein 8, endonuclease	Homo sapiens	59-63
22357182-6	2012	RESULTS: Compared with individuals with a 1-h postload plasma glucose &lt;155 mg/dL (NGT 1h-low), NGT 1h-high individuals exhibited lower insulin sensitivity after adjustment for age, sex, and BMI.	Hydrogen	102-104	insulin	Homo sapiens	138-145
21643969-0	2012	1H, 13C, and 15N resonance assignment of the SPFH domain of human stomatin.	Hydrogen	0-2	stomatin	Homo sapiens	66-74
22357182-8	2012	By contrast, compared with NGT 1h-low individuals, the acute insulin response during an IVGTT and the disposition index were significantly reduced in NGT 1h-high individuals after adjustment for age, sex, and BMI.	Hydrogen	31-33	insulin	Homo sapiens	61-68
22357182-8	2012	By contrast, compared with NGT 1h-low individuals, the acute insulin response during an IVGTT and the disposition index were significantly reduced in NGT 1h-high individuals after adjustment for age, sex, and BMI.	Hydrogen	154-156	insulin	Homo sapiens	61-68
22357182-10	2012	CONCLUSIONS: NGT 1h-high individuals may represent an intermediate state of glucose intolerance between NGT and type 2 diabetes characterized by insulin resistance and reduced beta-cell function, the two main pathophysiological defects responsible for the development of type 2 diabetes.	Hydrogen	17-19	insulin	Homo sapiens	145-152
22715785-6	2012	The strength between caffeic acid and alpha-casein was electrostatic attraction (deltaH &lt; 0, deltaS &gt; 0), and that between beta-casein and alpha-Lactalbumin was hydrogen bonding (deltaH &lt; 0, deltaS &lt; 0).	Hydrogen	167-175	lactalbumin alpha	Homo sapiens	145-162
21635208-5	2012	The docking results suggest that the thrombin inhibition by these heterocyclic compounds is driven by pi-pi, hydrogen bonds and salt bridge interactions.	Hydrogen	109-117	coagulation factor II, thrombin	Homo sapiens	37-45
22374326-5	2012	However, with the existence of hydrogen donor (o-phenylenediamine) in the reaction system, the peak binding level between MPO-ANCA-containing plasma and post-catalyzing MPO was significantly higher (1.367 +- 0.321 vs 1.135 +- 0.205, p = 0.023).	Hydrogen	31-39	myeloperoxidase	Homo sapiens	122-125
22374326-5	2012	However, with the existence of hydrogen donor (o-phenylenediamine) in the reaction system, the peak binding level between MPO-ANCA-containing plasma and post-catalyzing MPO was significantly higher (1.367 +- 0.321 vs 1.135 +- 0.205, p = 0.023).	Hydrogen	31-39	myeloperoxidase	Homo sapiens	169-172
22253009-6	2012	The metal binding domains of these compounds interacted with HDAC2, and the surface recognition domains of these compounds interacted with HDAC4 through hydrogen bonding.	Hydrogen	153-161	histone deacetylase 2	Homo sapiens	61-66
21805127-4	2012	The best pharmacophore model generated from 27 ATP-competitive mTOR inhibitors comprised two hydrogen-bond acceptors, one aromatic ring, and one hydrophobic feature.	Hydrogen	93-101	mechanistic target of rapamycin kinase	Homo sapiens	63-67
22337082-6	2012	The molecular modeling study further confirmed the specific binding sites of NF on HSA, such as the interaction between N11 and N14 of NF with Lue 283 and Ser 287 predominately through hydrogen bonds.	Hydrogen	185-193	albumin	Homo sapiens	83-86
22460088-10	2012	Radiation-induced caspase 3 activation was also attenuated by H2 treatment.	Hydrogen	62-64	caspase 3	Homo sapiens	18-27
22020754-1	2012	The unicellular green alga Chlamydomonas reinhardtii is able to use photosynthetically provided electrons for the production of molecular hydrogen by an [FeFe]-hydrogenase HYD1 accepting electrons from ferredoxin PetF.	Hydrogen	138-146	uncharacterized protein	Chlamydomonas reinhardtii	213-217
22264996-9	2012	Pain thresholds correlated with interleukin 6 at +1h (r=0.60, P&lt;.05) and +3h (r=0.67, P&lt;.05) within the LPS condition.	Hydrogen	50-52	interleukin 6	Homo sapiens	32-45
22294343-5	2012	Thus, much of the MeCP2 polypeptide chain undergoes coil-to-helix transitions under conditions that favor intrachain hydrogen bond formation.	Hydrogen	117-125	methyl-CpG binding protein 2	Homo sapiens	18-23
22235133-7	2012	We furthermore demonstrate that a sugar chain bridges the two fibronectin domains that constitute the extracellular domain of IL-21R and anchors at the WSXWS motif through an extensive hydrogen bonding network, including mannosylation.	Hydrogen	185-193	interleukin 21 receptor	Homo sapiens	126-132
22443767-0	2012	Quantum state-to-state dynamics for the quenching process of Br(2P1/2) + H2(v(i) = 0, 1, j(i) = 0).	Hydrogen	73-75	NADH:ubiquinone oxidoreductase complex assembly factor 3	Homo sapiens	64-69
22221921-7	2012	RESULTS: In the study group, the mean values of the serum S100B concentrations at 0-1h and 6-24h were 32.6+-7.8pg/ml and 32.1+-5.8pg/ml, respectively, while the concentrations were 32.1+-8.8pg/ml and 29.5+-7.8pg/ml in the control groups.	Hydrogen	84-86	S100 calcium binding protein B	Homo sapiens	58-63
22392975-4	2012	Here, we use hydrogen-deuterium exchange mass spectrometry to monitor region-specific folding of the canonical serpin human alpha(1)-antitrypsin (alpha(1)-AT).	Hydrogen	13-21	serpin family A member 1	Homo sapiens	124-144
22392975-4	2012	Here, we use hydrogen-deuterium exchange mass spectrometry to monitor region-specific folding of the canonical serpin human alpha(1)-antitrypsin (alpha(1)-AT).	Hydrogen	13-21	serpin family A member 1	Homo sapiens	146-157
22245093-6	2012	The PI3K/Akt pathway, which is upstream of NF-kappaB, plays a role in this activation, because (i) pretreatment with 15 d-PGJ(2) (10 muM for 1h) significantly (p<0.01) inhibited Mn (500 muM)-induced PI3K/Akt activation and (ii) inhibition of the PI3K/Akt pathway with LY29004 significantly (p<0.05) decreased NF-kappaB activation.	Hydrogen	141-143	AKT serine/threonine kinase 1	Homo sapiens	9-12
22361134-5	2012	Molecular modeling studies employing compound 20 showed that the phenyl CF(3) substituent attached to the CN spacer is positioned near the secondary pocket of the COX-2 active site, the CN nitrogen atom is hydrogen bonded (N   NH=2.85 A) to the H90 residue, and the indole N-1 benzoyl is positioned in a hydrophobic pocket of the COX-2 active site near W387.	Hydrogen	206-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168
22245093-6	2012	The PI3K/Akt pathway, which is upstream of NF-kappaB, plays a role in this activation, because (i) pretreatment with 15 d-PGJ(2) (10 muM for 1h) significantly (p<0.01) inhibited Mn (500 muM)-induced PI3K/Akt activation and (ii) inhibition of the PI3K/Akt pathway with LY29004 significantly (p<0.05) decreased NF-kappaB activation.	Hydrogen	141-143	nuclear factor kappa B subunit 1	Homo sapiens	43-52
22245093-6	2012	The PI3K/Akt pathway, which is upstream of NF-kappaB, plays a role in this activation, because (i) pretreatment with 15 d-PGJ(2) (10 muM for 1h) significantly (p<0.01) inhibited Mn (500 muM)-induced PI3K/Akt activation and (ii) inhibition of the PI3K/Akt pathway with LY29004 significantly (p<0.05) decreased NF-kappaB activation.	Hydrogen	141-143	AKT serine/threonine kinase 1	Homo sapiens	204-207
22245093-6	2012	The PI3K/Akt pathway, which is upstream of NF-kappaB, plays a role in this activation, because (i) pretreatment with 15 d-PGJ(2) (10 muM for 1h) significantly (p<0.01) inhibited Mn (500 muM)-induced PI3K/Akt activation and (ii) inhibition of the PI3K/Akt pathway with LY29004 significantly (p<0.05) decreased NF-kappaB activation.	Hydrogen	141-143	AKT serine/threonine kinase 1	Homo sapiens	204-207
22245093-6	2012	The PI3K/Akt pathway, which is upstream of NF-kappaB, plays a role in this activation, because (i) pretreatment with 15 d-PGJ(2) (10 muM for 1h) significantly (p<0.01) inhibited Mn (500 muM)-induced PI3K/Akt activation and (ii) inhibition of the PI3K/Akt pathway with LY29004 significantly (p<0.05) decreased NF-kappaB activation.	Hydrogen	141-143	nuclear factor kappa B subunit 1	Homo sapiens	309-318
22209213-0	2012	Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice.	Hydrogen	0-8	apolipoprotein E	Mus musculus	98-114
22582136-4	2012	The basis of ERalpha selectivity for BTPalpha was evaluated by using protein crystallography and hydrogen/deuterium exchange (HDX) mass spectrometry.	Hydrogen	97-105	estrogen receptor 1	Homo sapiens	13-20
22412529-5	2012	Mol-ecules are joined by bifurcated hydrogen bonds (N-H O and N-H S), forming a ladder-like arrangement along [100].	Hydrogen	36-44	NHS actin remodeling regulator	Homo sapiens	62-67
22209213-5	2012	Moreover, ELISA assay revealed that the production of tumor necrosis factor-alpha and interleukin-6 were significantly suppressed by hydrogen in RAW264.7 macrophages, after stimulation with the isolated non-HDL from treated or untreated mice.	Hydrogen	133-141	interleukin 6	Mus musculus	86-99
22209213-5	2012	Moreover, ELISA assay revealed that the production of tumor necrosis factor-alpha and interleukin-6 were significantly suppressed by hydrogen in RAW264.7 macrophages, after stimulation with the isolated non-HDL from treated or untreated mice.	Hydrogen	133-141	tumor necrosis factor	Mus musculus	54-81
22038699-2	2012	Both hydrogen bond basicity and dipolarity/polarizability of the ionic liquids were confirmed to be influential factors to control the solubilization of cytochrome c.	Hydrogen	5-13	cytochrome c, somatic	Homo sapiens	153-165
21855609-7	2012	The iron-release mechanism of transferrin N-lobe is also revealed by X-ray crystallography; two basic residues in two domains form an unusual hydrogen bond in neutral pH, and the bond should be broken and facilitate iron release at a low pH of the endosome.	Hydrogen	142-150	transferrin	Homo sapiens	30-41
22206963-0	2012	Postprandial plasma PYY concentrations are associated with increased regional gray matter volume and rCBF declines in caudate nuclei--a combined MRI and H2(15)O PET study.	Hydrogen	153-155	peptide YY	Homo sapiens	20-23
22311606-9	2012	The specific interaction between Gln50 and C18 and water-mediated hydrogen bond between Gln50 and T7 were found to be present during almost the entire time of the simulation.	Hydrogen	66-74	Bardet-Biedl syndrome 9	Homo sapiens	43-46
22284438-9	2012	Additional studies performed on UCHL3 by mutating the Gln to Glu (strong C-H   O acceptor but oxyanion destabilizer) and to Lys (strong oxyanion stabilizer but lacking C-H   O hydrogen-bonding capability) suggest that the C-H   O hydrogen bond could contribute to catalysis.	Hydrogen	230-238	ubiquitin C-terminal hydrolase L3	Homo sapiens	32-37
22271351-6	2012	Protein BSA may bind to CTS through hydrogen bonds, which causes the protein conformation to convert from beta-fold to alpha-helix.	Hydrogen	36-44	albumin	Homo sapiens	8-11
22420928-0	2012	Photocatalytic hydrogen evolution by a diiron hydrogenase model based on a peptide fragment of cytochrome c556 with an attached diiron carbonyl cluster and an attached ruthenium photosensitizer.	Hydrogen	15-23	cytochrome c, somatic	Homo sapiens	95-107
22296509-6	2012	In the case of uracil-DNA glycosylase (UNG), which catalyzes the hydrolytic excision of uracil from DNA, the type of discrete hydrogen-bonding interactions with U, the nature of the nucleophile, and the anticipated weak, nonpolar environment in the active site suggest that phenylalanine will be slightly anticatalytic in the chemical step, and therefore experimentally observed contributions to catalysis may entirely result from associated structural changes that occur prior to deglycosylation.	Hydrogen	126-134	uracil DNA glycosylase	Homo sapiens	15-37
22296509-6	2012	In the case of uracil-DNA glycosylase (UNG), which catalyzes the hydrolytic excision of uracil from DNA, the type of discrete hydrogen-bonding interactions with U, the nature of the nucleophile, and the anticipated weak, nonpolar environment in the active site suggest that phenylalanine will be slightly anticatalytic in the chemical step, and therefore experimentally observed contributions to catalysis may entirely result from associated structural changes that occur prior to deglycosylation.	Hydrogen	126-134	uracil DNA glycosylase	Homo sapiens	39-42
22214241-2	2012	We examine the concentration and pressure of hydrogen gas as a function of temperature in which abstraction of oxygen is possible with minimum damage to C-sp(2) bonds, hence preserving the integrity of the graphene sheet.	Hydrogen	45-53	regulator of calcineurin 2	Homo sapiens	153-160
22281499-6	2012	Hydrogen/deuterium exchange mass spectrometry further reveals reduced backbone accessibility in insulin aggregates formed in the presence of C-peptide.	Hydrogen	0-8	insulin	Homo sapiens	96-103
22281499-6	2012	Hydrogen/deuterium exchange mass spectrometry further reveals reduced backbone accessibility in insulin aggregates formed in the presence of C-peptide.	Hydrogen	0-8	insulin	Homo sapiens	141-150
22587099-6	2012	In turn, the case of the first hydration layers of the lysozyme molecule is shown to be more complicated, but still displaying signs of both kinds of behavior, together with a tendency of the proximal water molecules to hydrogen bond to the protein both as donors and as acceptors.	Hydrogen	220-228	lysozyme	Homo sapiens	55-63
22645764-10	2012	The results of molecular model studies revealed that the binding modes for drug-serum albumin systems are mainly hydrophobic interactions and hydrogen bonding.	Hydrogen	142-150	albumin	Homo sapiens	80-93
22260165-6	2012	The absence of strongly hydrogen-bonded water molecules (O-D stretch at &lt;2400 cm(-1)) is common between rhodopsin and color pigments, which greatly contrasts with the case of proton-pumping microbial rhodopsins.	Hydrogen	24-32	rhodopsin	Homo sapiens	107-116
22102294-3	2012	Therefore, this study investigated the conformational features of the prohormone proenkephalin (PE) by rapid hydrogen-deuterium exchange mass spectrometry (DXMS).	Hydrogen	109-117	proenkephalin	Homo sapiens	81-94
22249951-8	2012	3) Independent of the nature of the substituent R in NH(R)BH(3), the formation of H(2) was observed at around 50  C. 4) In all cases, the complex [Ca(DIPP-nacnac)(NH(2))](2) was formed as a major product of thermal decomposition, and its dimeric nature was confirmed by single-crystal analysis.	Hydrogen	82-86	nudix hydrolase 3	Homo sapiens	150-154
22153150-0	2012	Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-alpha/NF-kappaB pathway.	Hydrogen	0-8	tumor necrosis factor	Rattus norvegicus	106-115
22019695-5	2012	Erk1/2 was activated within 1h of sulforaphane addition, whereas Akt phosphorylation was suppressed until the first 8h, and was then maintained at an elevated level until 72h, displaying a biphasic regulatory feature.	Hydrogen	28-30	mitogen-activated protein kinase 3	Homo sapiens	0-6
26596595-8	2012	Application of the LOC scheme to the rate-determining hydrogen atom transfer step in substrate hydroxylation by cytochrome P450 shows that this approach is able to correct the B3LYP barriers in comparison to recent kinetics experiments.	Hydrogen	54-62	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	112-127
22346895-5	2012	The carboxyl end of the 3-carb-oxy-benzoate connects to a neighbouring chain by employing its carbonyl atom to form a bond to a Pb(II) atom and the hydroxyl group to form a hydrogen bond to a quinolin-8-olate O atom.	Hydrogen	173-181	submaxillary gland androgen regulated protein 3B	Homo sapiens	128-134
22005015-6	2012	In the present study, we employed insulin-like growth factor-1 as an inducer of Akt signalling, and showed that it increased sterol-regulatory element binding protein-2 activation acutely (within 1h).	Hydrogen	196-198	insulin like growth factor 1	Homo sapiens	34-62
22005015-6	2012	In the present study, we employed insulin-like growth factor-1 as an inducer of Akt signalling, and showed that it increased sterol-regulatory element binding protein-2 activation acutely (within 1h).	Hydrogen	196-198	sterol regulatory element binding transcription factor 2	Homo sapiens	125-168
22154891-2	2012	Guided by complex crystal structures, we employed the initially identified N-aryl, N"-thiazole urea scaffold and introduced key structural elements that allowed the formation of novel hydrogen bonding interactions within the allosteric site of p38alpha, resulting in potent type III inhibitors.	Hydrogen	184-192	mitogen-activated protein kinase 14	Homo sapiens	244-252
21954110-9	2012	A total of 431 (90.4%) of patients had a hs-cTnT &lt;=14 ng/l.	Hydrogen	41-43	troponin T2, cardiac type	Homo sapiens	44-48
22382411-0	2012	A new approach to characterization of insulin derived from different species using 1H-NMR coupled with multivariate analysis.	Hydrogen	83-85	insulin	Homo sapiens	38-45
22172011-6	2012	Besides the electrostatic interactions, especially through hydrogen bond formation, the van der Waals (vdW) interactions with the I19, V27, F98, H100, and L152 residues of CDK6 are also important factors in the binding efficiency of flavonoids against the CDK6/cycD complex.	Hydrogen	59-67	cyclin dependent kinase 6	Homo sapiens	172-176
21951784-0	2012	Analysis of oligomeric stability of insulin analogs using hydrogen/deuterium exchange mass spectrometry.	Hydrogen	58-66	insulin	Homo sapiens	36-43
21951784-3	2012	To investigate the oligomeric stability of insulin analog products having different pharmacokinetics, we performed hydrogen/deuterium exchange mass spectrometry (HDX/MS), which is a rapid method to analyze dynamic aspects of protein structures.	Hydrogen	115-123	insulin	Homo sapiens	43-50
22829723-12	2012	The docking of quercetin with CB1 receptor showed a binding energy of -6.56 Kcal/mol with 4 hydrogen bonds, in comparison to the known drug Rimonabant.	Hydrogen	92-100	cannabinoid receptor 1	Homo sapiens	30-33
22084399-6	2012	The xanthone moiety in norathyriol acted as an adenine mimetic to anchor the compound by hydrogen bonds to the hinge region of the protein ATP-binding site on ERK2.	Hydrogen	89-97	mitogen-activated protein kinase 1	Mus musculus	159-163
22142421-0	2012	EPR-ENDOR characterization of (17O, 1H, 2H) water in manganese catalase and its relevance to the oxygen-evolving complex of photosystem II.	Hydrogen	36-38	catalase	Homo sapiens	63-71
22359440-6	2012	The results indicated that amino acid ARG82, ARG84 and HIS197 present in endothelin B receptor are core important for binding activities and these residues are having strong hydrogen bond interactions with Bosentan.	Hydrogen	174-182	endothelin receptor type B	Homo sapiens	73-94
22382411-5	2012	However, we have been able to distinguish between three insulin species differing in one to three amino acid residues using a combination of multivariate statistics and 1H-NMR spectra.	Hydrogen	169-171	insulin	Homo sapiens	56-63
22352915-7	2012	Moreover, the study indicated that the antagonist activity of these derivatives is largely explained by electrostatic, steric and hydrogen-bonding factors, highlighting the role of the size, shape and type of inhibitor in forming effective blocking of the A3 AR subtype.	Hydrogen	130-138	adenosine A3 receptor	Homo sapiens	256-261
21846324-3	2012	Firstly, we developed and validated a pharmacophore model for CYP2D6 inhibitors, which consisted of two hydrophobic features and one hydrogen bond acceptor feature.	Hydrogen	133-141	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	62-68
21777186-9	2012	The C-terminus of the PTH1R binds to the sodium-hydrogen regulatory factors (NHERFs) via a PDZ domain-mediated interaction, an association that influences signaling and membrane anchoring.	Hydrogen	48-56	parathyroid hormone 1 receptor	Homo sapiens	22-27
22854122-7	2012	Structural and molecular interaction studies on the training and test sets suggest that designing novel compounds hydrogen bond with Asp128 in the bioactive region of Pim-1 kinase would result in therapeutic success.	Hydrogen	114-122	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	167-172
23185443-0	2012	H(2) enhances arabidopsis salt tolerance by manipulating ZAT10/12-mediated antioxidant defence and controlling sodium exclusion.	Hydrogen	0-4	salt tolerance zinc finger	Arabidopsis thaliana	57-62
22150676-11	2012	3,4-Dimethoxyl substituted aromatic acyls, bearing a methoxy that might interact with Pgp as hydrogen bond accepter, were shown to be the most potent for reversing MDR.	Hydrogen	93-101	ATP binding cassette subfamily B member 1	Homo sapiens	86-89
23152789-9	2012	Cavity analyses suggest the presence of a reasonably sized bifurcated cavity in antithrombin that facilitates a firm "hand-shake" with H/HS, but with thrombin, a weaker "high-five".	Hydrogen	137-139	coagulation factor II, thrombin	Homo sapiens	84-92
21956503-5	2012	However, the number of cells secreting TH2 cytokines IL-4 and IL-5 in hydrogen -peroxide-treated group did not change.	Hydrogen	70-78	interleukin 4	Homo sapiens	53-57
23189124-5	2012	During all MD simulation of the fMLF-FPR1 complex a water molecule transiently bridged the hydrogen bond between W254(6.48) and N108(3.35) in the middle of the receptor.	Hydrogen	91-99	formyl peptide receptor 1	Homo sapiens	37-41
23185443-7	2012	Further results showed that H(2) pretreatment modulated genes/proteins of zinc-finger transcription factor ZAT10/12 and related antioxidant defence enzymes, thus significantly counteracting the NaCl-induced reactive oxygen species (ROS) overproduction and lipid peroxidation.	Hydrogen	28-32	salt tolerance zinc finger	Arabidopsis thaliana	107-115
23185443-10	2012	CONCLUSIONS: Overall, our findings indicate that H(2) acts as a novel and cytoprotective regulator in coupling ZAT10/12-mediated antioxidant defence and maintenance of ion homeostasis in the improvement of Arabidopsis salt tolerance.	Hydrogen	49-53	salt tolerance zinc finger	Arabidopsis thaliana	111-116
22558517-9	2012	Plasma ET-1 in hypoxia during the bosentan period was 2.8 times higher than during for both CS and HS.	Hydrogen	99-101	endothelin 1	Homo sapiens	7-11
21960464-6	2012	The movement initiates rearrangement of the system of hydrogen bonds between TM2, TM3 and TM7 including formation of the hydrogen bond between the side chains of D82(2.50) in TM2 and N296(7.49) in TM7, which is crucial for formation of the activated states of the C5a receptors (Nikiforovich et al., Proteins: Struct Funct Gene 2011;79:787-802).	Hydrogen	54-62	complement C5a receptor 1	Homo sapiens	264-267
21960464-6	2012	The movement initiates rearrangement of the system of hydrogen bonds between TM2, TM3 and TM7 including formation of the hydrogen bond between the side chains of D82(2.50) in TM2 and N296(7.49) in TM7, which is crucial for formation of the activated states of the C5a receptors (Nikiforovich et al., Proteins: Struct Funct Gene 2011;79:787-802).	Hydrogen	121-129	complement C5a receptor 1	Homo sapiens	264-267
22470497-10	2012	We further propose a third binding site on KLC1 which involves a stretch of polar residues along the inter-TPR loops that may form a network of hydrogen bonds to JIP3 and JIP4.	Hydrogen	144-152	kinesin light chain 1	Homo sapiens	43-47
22098575-7	2011	Hydrogen bonds between Asp301 and His254 were persistent in the OPH-paraoxon complex but not in the OPH-soman one, suggesting a potential role for such interaction in the more efficient hydrolysis of paraoxon over soman by OPH.	Hydrogen	0-8	acylaminoacyl-peptide hydrolase	Homo sapiens	64-67
22052799-6	2011	The selectivity of HP1alpha chromodomain for H3K9Me(3)  over H3K9Me(2)  was investigated by mutating E52 to remove or weaken the hydrogen bond to K9Me(2)  while maintaining affinity for K9Me(3,)  including E52F, E52I, E52V, E52D, an E52Q.	Hydrogen	129-137	Suppressor of variegation 205	Drosophila melanogaster	19-27
22097958-7	2011	Furthermore, binding free energies decomposition analysis and further structural analysis indicate that the dominating effect of van der Waals interaction drives the binding process, and key residues, such as Lys53, Gly71, Leu75, Ile84, Thr106, Met109, Leu167, Asp168, and Phe169, play important roles by forming hydrogen bond, salt bridge, and hydrophobic interactions with the DFG-out conformation of p38alpha.	Hydrogen	313-321	mitogen-activated protein kinase 14	Homo sapiens	403-411
22060818-3	2011	Hydrogen/deuterium exchange studies by NMR-spectroscopy show that MpDHFR is a more flexible enzyme than EcDHFR.	Hydrogen	0-8	dihydrofolate reductase	Escherichia coli	104-110
22085260-0	2011	Total synthesis of the potent androgen receptor antagonist (-)-arabilin: a strategic, biomimetic [1,7]-hydrogen shift.	Hydrogen	103-111	androgen receptor	Homo sapiens	30-47
22027839-4	2011	We have used small angle x-ray scattering, hydrogen/deuterium exchange kinetics, and Forster resonance energy transfer measurements to determine the low-resolution solution structure of the 14-3-3zeta RGS3 complex.	Hydrogen	43-51	regulator of G protein signaling 3	Homo sapiens	201-205
22061644-3	2011	Dihydrobenzoxathiin diastereomers with full antagonistic activity form more stable hydrogen bonds with Glu353 and His524 of ER alpha LBD than corresponding diastereomers.	Hydrogen	83-91	estrogen receptor 1	Homo sapiens	124-132
22052592-7	2011	The chiral phosphate anion (O-P*) controls the enantioselectivity through formation of a loose ion pair with the metal center and establishes a C-H   O-P* hydrogen bond with the substrate.	Hydrogen	155-163	DNA damage inducible transcript 3	Homo sapiens	144-153
22034624-1	2011	Our theoretical studies of the standard reduction potentials of the molecular complex [Co(II)(dmgBF(2))(2)](0) (dmgBF(2) = difluoro-boryldimethylglyoximate) in acetonitrile solution shed light on its electrocatalytic mechanism for hydrogen production.	Hydrogen	231-239	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
22168696-8	2011	It is concluded that -CF(3) is less effective than -Cl as an electron-withdrawing group when attached to an I atom and that the angular geometries of the B   ICF(3) can be predicted by means of a simple rule that holds for many hydrogen- and halogen-bonded complexes.	Hydrogen	228-236	cell division cycle associated 7	Homo sapiens	158-164
21989504-3	2011	Three imidazole groups per Delta- or Lambda-fac-[Fe(II)(HL(n-Pr))(3)](2+) are hydrogen-bonded to three Cl(-) ions or, from the viewpoint of the Cl(-) ion, one Cl(-) ion is hydrogen-bonded to three neighbouring fac-[Fe(II)(HL(n-Pr))(3)](2+) cations.	Hydrogen	78-86	FA complementation group C	Homo sapiens	44-47
21989504-3	2011	Three imidazole groups per Delta- or Lambda-fac-[Fe(II)(HL(n-Pr))(3)](2+) are hydrogen-bonded to three Cl(-) ions or, from the viewpoint of the Cl(-) ion, one Cl(-) ion is hydrogen-bonded to three neighbouring fac-[Fe(II)(HL(n-Pr))(3)](2+) cations.	Hydrogen	78-86	FA complementation group C	Homo sapiens	210-213
21989504-3	2011	Three imidazole groups per Delta- or Lambda-fac-[Fe(II)(HL(n-Pr))(3)](2+) are hydrogen-bonded to three Cl(-) ions or, from the viewpoint of the Cl(-) ion, one Cl(-) ion is hydrogen-bonded to three neighbouring fac-[Fe(II)(HL(n-Pr))(3)](2+) cations.	Hydrogen	172-180	FA complementation group C	Homo sapiens	44-47
21989504-4	2011	The 3 : 3 NH   Cl(-) hydrogen bonds between Delta- or Lambda-fac-[Fe(II)(HL(n-Pr))(3)](2+) and Cl(-) generate two kinds of assembly structures.	Hydrogen	21-29	FA complementation group C	Homo sapiens	61-64
21974881-4	2011	After the anode arrangement optimization, the current and hydrogen production rate (HPR) of MEC could be enhanced by 72% and 118%, reaching 621.3+-20.6 A/m3 and 5.56 m3/m3 d respectively, under 0.8 V applied voltage.	Hydrogen	58-66	C-C motif chemokine ligand 28	Homo sapiens	92-95
21970497-3	2011	The binding process was spontaneous and the resveratrol-thrombin complex formation was an endothermal reaction induced by hydrophobic interaction and hydrogen.	Hydrogen	150-158	coagulation factor II, thrombin	Homo sapiens	56-64
21380921-1	2011	Two novel and facile ligands ammonium piperidine dithiocarbamate (Amm Pip-DTC) and ammonium morpholine dithiocarbamate (Amm Mor-DTC) were synthesized for the development of rapid and cost effective catalytic hydrogen current technique to analyze cobalt(II) in the presence of NH(4)Cl-NH(4)OH at pH 7.8 and 8.4 with Amm Pip-DTC and Amm Mor-DTC.	Hydrogen	208-216	prolactin induced protein	Homo sapiens	70-73
21380921-2	2011	These ligands produce catalytic hydrogen currents with Co(II) at peak potentials -1.24 V and -1.44 V vs. SCE respectively.	Hydrogen	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-61
22015602-9	2011	In addition, hydrogen decreased malonaldehyde and nitrotyrosine content, inhibited myeloperoxidase and maintained superoxide dismutase activity in lung tissues and associated with a decrease in the expression of TNF-alpha, IL-1beta, IL-6 and total protein concentrations in the BALF.	Hydrogen	13-21	tumor necrosis factor	Mus musculus	212-221
22015602-9	2011	In addition, hydrogen decreased malonaldehyde and nitrotyrosine content, inhibited myeloperoxidase and maintained superoxide dismutase activity in lung tissues and associated with a decrease in the expression of TNF-alpha, IL-1beta, IL-6 and total protein concentrations in the BALF.	Hydrogen	13-21	interleukin 1 beta	Mus musculus	223-231
22015602-9	2011	In addition, hydrogen decreased malonaldehyde and nitrotyrosine content, inhibited myeloperoxidase and maintained superoxide dismutase activity in lung tissues and associated with a decrease in the expression of TNF-alpha, IL-1beta, IL-6 and total protein concentrations in the BALF.	Hydrogen	13-21	interleukin 6	Mus musculus	233-237
22070307-4	2011	The spectral analysis using the Morse potential yields a hydrogen bond distance of 0.734 A at 6 GPa--slightly shorter than that in pure--attributed to the repulsive interaction.	Hydrogen	57-65	glycophorin A (MNS blood group)	Homo sapiens	96-99
22032174-2	2011	Here, we use hydrogen exchange protection factors in restrained molecular dynamics simulations to characterize long-time scale fluctuations in human PrP(C).	Hydrogen	13-21	prion protein	Homo sapiens	149-155
22105349-4	2011	We provide evidence that cortactin-cofilin binding is regulated by local pH changes at invadopodia that are mediated by the sodium-hydrogen exchanger NHE1.	Hydrogen	131-139	solute carrier family 9 member A1	Homo sapiens	150-154
21985639-3	2011	In the thienopyrimidine series of inhibitors, we propose that select ligands achieve selectivity derived from a hydrogen bonding interaction with Arg770 of PI3Kalpha that is not attained with the corresponding Lys777 of PI3Kbeta.	Hydrogen	112-120	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	156-165
22026550-2	2011	The cations fac-[Fe(II)(HL(R))(3)](2+) and chloride anions associate through 3:3 imidazole   chloride hydrogen bonding.	Hydrogen	102-110	FA complementation group C	Homo sapiens	12-15
21942543-13	2011	The thermodynamically favored bimetallic pathways also pass through the Co(III)H intermediate, but the pathways in which two Co(III)H or two Co(II)H complexes react to produce H(2) are not thermodynamically distinguishable with these methods.	Hydrogen	176-180	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	75-78
21942543-13	2011	The thermodynamically favored bimetallic pathways also pass through the Co(III)H intermediate, but the pathways in which two Co(III)H or two Co(II)H complexes react to produce H(2) are not thermodynamically distinguishable with these methods.	Hydrogen	176-180	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	128-131
21942543-14	2011	On the basis of the electrostatic work term associated with bringing the two cobalt complexes together in solution, the preferred bimetallic pathway involves the reaction of two Co(III)H complexes to produce H(2).	Hydrogen	208-212	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	181-184
21956195-5	2011	RESULTS: During the early phase of ischemia-reperfusion injury, hydrogen-enriched solution significantly preserved mucosal graft morphology, diminished graft malondialdehyde levels demonstrating substantial reduction potential and blunted proinflammatory molecular responses (early growth response gene [EGR-1], interleukin [IL]-6, IL-1ss, and inducible nitric oxide synthase) within the reperfused intestinal graft muscularis.	Hydrogen	64-72	early growth response 1	Rattus norvegicus	304-309
21956195-5	2011	RESULTS: During the early phase of ischemia-reperfusion injury, hydrogen-enriched solution significantly preserved mucosal graft morphology, diminished graft malondialdehyde levels demonstrating substantial reduction potential and blunted proinflammatory molecular responses (early growth response gene [EGR-1], interleukin [IL]-6, IL-1ss, and inducible nitric oxide synthase) within the reperfused intestinal graft muscularis.	Hydrogen	64-72	nitric oxide synthase 2	Rattus norvegicus	344-375
21880715-7	2011	In addition, a unique EDEE motif between the loop of anti-parallel beta7 and beta8 sheets of the SET core not only interacts with p53 substrate but also forms a hydrogen bond network with residues from CTD.	Hydrogen	161-169	tumor protein p53	Homo sapiens	130-133
21852690-9	2011	We conclude that COX-1 and MnLOX can readily abstract allylic hydrogens of octadecenoic fatty acids from C-10 to C-12 and 8R-DOX from C-7 and C-12.	Hydrogen	62-71	prostaglandin-endoperoxide synthase 1	Homo sapiens	17-22
21921035-4	2011	We apply the model to WT rhodopsin and E181Q and S186A mutants at 55  C, as well as WT rhodopsin in H(2)O and D(2)O at 59  C. The results show that the hydrogen-bonding network strongly restrains thermal isomerization but is less important in opsin and activated rhodopsin.	Hydrogen	152-160	rhodopsin	Homo sapiens	25-34
21921035-4	2011	We apply the model to WT rhodopsin and E181Q and S186A mutants at 55  C, as well as WT rhodopsin in H(2)O and D(2)O at 59  C. The results show that the hydrogen-bonding network strongly restrains thermal isomerization but is less important in opsin and activated rhodopsin.	Hydrogen	152-160	rhodopsin	Homo sapiens	87-96
21921035-4	2011	We apply the model to WT rhodopsin and E181Q and S186A mutants at 55  C, as well as WT rhodopsin in H(2)O and D(2)O at 59  C. The results show that the hydrogen-bonding network strongly restrains thermal isomerization but is less important in opsin and activated rhodopsin.	Hydrogen	152-160	rhodopsin	Homo sapiens	87-96
21919496-3	2011	We identify and characterize the hydrogen-bond network, responsible for the mutual interaction of the LeX pairs, whereas we find the intramolecular conformation and stability to be mainly assured by dispersion forces.	Hydrogen	33-41	fucosyltransferase 4	Homo sapiens	102-105
21899263-0	2011	Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization.	Hydrogen	0-8	apolipoprotein E	Homo sapiens	121-137
21899263-5	2011	Here we report the use of hydrogen/deuterium exchange (H/DX) coupled with enzymatic digestion to identify those regions in the sequence of full-length apoE involved in oligomerization.	Hydrogen	26-34	apolipoprotein E	Homo sapiens	151-155
21741329-6	2011	It was shown that the hydrogen bonds of Ser60 and Val214 to the carboxyl group of Asp are important components during substrate recognition by PIMT.	Hydrogen	22-30	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	143-147
21741329-7	2011	In addition, specific hydrogen bonds were observed between the main chains of the substrates and those of Ala61 and Ile212 of PIMT when PIMT recognized L-beta-Asp.	Hydrogen	22-30	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	126-130
21741329-7	2011	In addition, specific hydrogen bonds were observed between the main chains of the substrates and those of Ala61 and Ile212 of PIMT when PIMT recognized L-beta-Asp.	Hydrogen	22-30	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	136-140
21942621-4	2011	In contrast, the network of hydrogen bonds in the active site is more stable in the complex of BACE with the gem-diol intermediate than the other two states of the substrate.	Hydrogen	28-36	beta-secretase 1	Homo sapiens	95-99
21382910-4	2011	RESULTS: The levels of IL-6 and TNF-alpha were increased from 1h up to 1w and 6h, respectively, in both RFA groups, while IL-6 was only mildly increased at 3 h in group P. IL-6 was higher in group RFA + P compared to group RFA.	Hydrogen	62-64	interleukin 6	Rattus norvegicus	23-27
21382910-4	2011	RESULTS: The levels of IL-6 and TNF-alpha were increased from 1h up to 1w and 6h, respectively, in both RFA groups, while IL-6 was only mildly increased at 3 h in group P. IL-6 was higher in group RFA + P compared to group RFA.	Hydrogen	62-64	tumor necrosis factor	Rattus norvegicus	32-41
21664691-3	2011	In this report, we demonstrate that LtxA induces very rapid (1h) apoptosis in acute monocytic leukemia THP-1 cells characterized by binding of annexin V to cells, loss of mitochondrial membrane potential, depletion of cellular ATP, and fragmentation of chromosomal DNA.	Hydrogen	61-63	GLI family zinc finger 2	Homo sapiens	103-108
21360476-7	2011	Up-regulated genes included major histocompatibility complex (HLA-C), complement component 3a receptor 1 (C3AR1), solute carrier family 16, member 3 (SLC16A3) and solute carrier family 9 (sodium/hydrogen exchanger) (SLC9A8).	Hydrogen	195-203	solute carrier family 9 member C2 (putative)	Homo sapiens	163-186
22649374-5	2011	Long-lived hydrogen bonds (as defined by global exchange kinetics) exist only at a subset of four alpha-helical sites (two per chain) flanking an internal disulfide bridge (cystine A20-B19); these sites map within the proposed folding nucleus of proinsulin.	Hydrogen	11-19	insulin	Homo sapiens	246-256
22047243-0	2011	New ab initio coupled potential energy surfaces for the Br(2P(3/2), 2P(1/2)) + H2 reaction.	Hydrogen	79-81	NADH:ubiquinone oxidoreductase complex assembly factor 3	Homo sapiens	68-76
21880708-0	2011	Non-equivalent role of inter- and intramolecular hydrogen bonds in the insulin dimer interface.	Hydrogen	49-57	insulin	Homo sapiens	71-78
21919442-5	2011	These irregular, micrometer-sized DBS structures (microaggregates) may have formed because the aggregated DBS molecules were influenced by the MMA monomers, due to the hydrogen bonding between DBS and MMA.	Hydrogen	168-176	monocyte to macrophage differentiation associated	Homo sapiens	143-146
21919442-5	2011	These irregular, micrometer-sized DBS structures (microaggregates) may have formed because the aggregated DBS molecules were influenced by the MMA monomers, due to the hydrogen bonding between DBS and MMA.	Hydrogen	168-176	monocyte to macrophage differentiation associated	Homo sapiens	201-204
21767980-0	2011	Elaborated 1H NMR study for the ligitional behavior of two thiosemicarbazide derivatives towards some heavy metals (Sn(II), Sb(III), Pb(II) and Bi(III)), thermal, antibacterial and antifungal studies.	Hydrogen	11-13	submaxillary gland androgen regulated protein 3B	Homo sapiens	133-139
21890358-3	2011	Molecular modeling studies for 9f showed that the SO(2)NH(2) group assumes a position within the secondary pocket of the COX-2 active site wherein the SO(2)NH(2) oxygen atom is hydrogen bonded to the H90 residue (2.90A), the SO(2)NH(2) nitrogen atom forms a hydrogen bond with L352 (N O=2.80A), and the acetyl group is positioned in the vicinity of the S530 residue where the acetyl oxygen atom undergoes hydrogen bonding to L531 (2.99A).	Hydrogen	177-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21890358-3	2011	Molecular modeling studies for 9f showed that the SO(2)NH(2) group assumes a position within the secondary pocket of the COX-2 active site wherein the SO(2)NH(2) oxygen atom is hydrogen bonded to the H90 residue (2.90A), the SO(2)NH(2) nitrogen atom forms a hydrogen bond with L352 (N O=2.80A), and the acetyl group is positioned in the vicinity of the S530 residue where the acetyl oxygen atom undergoes hydrogen bonding to L531 (2.99A).	Hydrogen	258-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21890358-3	2011	Molecular modeling studies for 9f showed that the SO(2)NH(2) group assumes a position within the secondary pocket of the COX-2 active site wherein the SO(2)NH(2) oxygen atom is hydrogen bonded to the H90 residue (2.90A), the SO(2)NH(2) nitrogen atom forms a hydrogen bond with L352 (N O=2.80A), and the acetyl group is positioned in the vicinity of the S530 residue where the acetyl oxygen atom undergoes hydrogen bonding to L531 (2.99A).	Hydrogen	258-266	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21918298-1	2011	We show that hydrogen titanate (H(2)Ti(3)O(7)) nanotubes form strongly associated reversible nano-bio-conjugates with the vital respiratory protein, cytochrome c.	Hydrogen	13-21	cytochrome c, somatic	Homo sapiens	149-161
21918198-8	2011	TLR4 signaling was required to mediate DC H2-O downregulation in response to LPS.	Hydrogen	42-44	toll-like receptor 4	Mus musculus	0-4
21863185-0	2011	New imidazopyridopyrimidine:naphthyridine base-pairing motif, ImN(N):NaO(O), consisting of a DAAD:ADDA hydrogen bonding pattern, markedly stabilize DNA duplexes.	Hydrogen	103-111	adducin 1	Homo sapiens	98-102
21863185-2	2011	Among the base pairs examined, DNA duplexes containing ImN(N):NaO(O) pair(s) consisting of a DAAD:ADDA hydrogen bonding pattern (D = donor, A = acceptor) were markedly stabilized thermally and thermodynamically.	Hydrogen	103-111	adducin 1	Homo sapiens	98-102
21918298-1	2011	We show that hydrogen titanate (H(2)Ti(3)O(7)) nanotubes form strongly associated reversible nano-bio-conjugates with the vital respiratory protein, cytochrome c.	Hydrogen	32-36	cytochrome c, somatic	Homo sapiens	149-161
21863858-8	2011	A larger difference in electronic structure is observed between the human isoforms and P450(cam) and may be explained by the slightly different hydrogen-bonding environment surrounding the cysteinyl sulfur.	Hydrogen	144-152	calmodulin 3	Homo sapiens	87-96
21902213-0	2011	Hydrogen tunneling steps in cyclooxygenase-2 catalysis.	Hydrogen	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	28-44
21898612-2	2011	Next, intramolecular sequential double hydrogen-atom transfer from the methyl group concomitant with the elimination of two acetic acid molecules produces Pt(2)CH(+) from which, upon even harsher conditions, PtCH(+) is eventually generated.	Hydrogen	39-47	patched 1	Homo sapiens	208-212
21870879-9	2011	This site-specific localization of the positive charge enhances the acidity of the terminal NH(2) group, facilitating hydrogen transfer from the NH(2) to the COCH(3) end of the molecular ion.	Hydrogen	118-126	cochlin	Homo sapiens	158-162
21757036-9	2011	The surface properties of the glasses, which can be modulated by media pH, glass composition and final stabilisation temperature in the sol-gel process, have effects on fibrinogen adsorption via long-range Coulombic forces before the adsorption and via short-range interactions such as hydrogen bonding after the adsorption.	Hydrogen	286-294	fibrinogen beta chain	Homo sapiens	169-179
21689722-4	2011	Using hydrogen-deuterium exchange mass spectrometry, we showed that the C-terminal region of M-ficolin FBG underwent dramatic conformational change upon pH and calcium perturbations.	Hydrogen	6-14	ficolin 1	Homo sapiens	93-102
21936798-3	2011	To this end, hydrogen-transfer reactions have been observed between cysteine thiyl radicals and glycine, alanine, serine, valine and leucine in both model peptides and a protein, insulin.	Hydrogen	13-21	insulin	Homo sapiens	179-186
21859105-5	2011	Two vibrational absorption peaks were observed at room temperature in the nitrile region when the inhibitor binds to wild-type hALR2, indicating that the nitrile probe experiences two different microenvironments, and these could be empirically separated into a hydrogen-bonded and non-hydrogen-bonded population by comparison with the T113A mutant, in which a hydrogen bond to the nitrile is not present.	Hydrogen	261-269	aldo-keto reductase family 1 member B	Homo sapiens	127-132
21859105-5	2011	Two vibrational absorption peaks were observed at room temperature in the nitrile region when the inhibitor binds to wild-type hALR2, indicating that the nitrile probe experiences two different microenvironments, and these could be empirically separated into a hydrogen-bonded and non-hydrogen-bonded population by comparison with the T113A mutant, in which a hydrogen bond to the nitrile is not present.	Hydrogen	285-293	aldo-keto reductase family 1 member B	Homo sapiens	127-132
21859105-5	2011	Two vibrational absorption peaks were observed at room temperature in the nitrile region when the inhibitor binds to wild-type hALR2, indicating that the nitrile probe experiences two different microenvironments, and these could be empirically separated into a hydrogen-bonded and non-hydrogen-bonded population by comparison with the T113A mutant, in which a hydrogen bond to the nitrile is not present.	Hydrogen	285-293	aldo-keto reductase family 1 member B	Homo sapiens	127-132
21350922-0	2011	1H, 13C, and 15N resonance assignments for the CTD-interacting domain of Nrd1 bound to Ser5-phosphorylated CTD of RNA polymerase II.	Hydrogen	0-2	nardilysin convertase	Homo sapiens	73-77
21431884-0	2011	1H, 13C, and 15N resonance assignment of the first PDZ domain of mouse ZO-1.	Hydrogen	0-2	tight junction protein 1	Mus musculus	71-75
21620965-3	2011	A preparation comprised mainly of Band 2 PDE5 was partially converted to Band 3 PDE5 by 1h incubation with cGMP or the PDE5-specific inhibitors sildenafil, vardenafil, or tadalafil, but not with cAMP, milrinone (PDE3-specific), or rolipram (PDE4-specific).	Hydrogen	88-90	phosphodiesterase 5A	Homo sapiens	41-45
21620965-3	2011	A preparation comprised mainly of Band 2 PDE5 was partially converted to Band 3 PDE5 by 1h incubation with cGMP or the PDE5-specific inhibitors sildenafil, vardenafil, or tadalafil, but not with cAMP, milrinone (PDE3-specific), or rolipram (PDE4-specific).	Hydrogen	88-90	phosphodiesterase 5A	Homo sapiens	80-84
21620965-3	2011	A preparation comprised mainly of Band 2 PDE5 was partially converted to Band 3 PDE5 by 1h incubation with cGMP or the PDE5-specific inhibitors sildenafil, vardenafil, or tadalafil, but not with cAMP, milrinone (PDE3-specific), or rolipram (PDE4-specific).	Hydrogen	88-90	phosphodiesterase 5A	Homo sapiens	80-84
21780215-0	2011	Hydrogen-deuterium exchange in vivo to measure turnover of an ALS-associated mutant SOD1 protein in spinal cord of mice.	Hydrogen	0-8	superoxide dismutase 1, soluble	Mus musculus	84-88
21258830-5	2011	QTAIM identified the weak H-bonds formed between the methyl hydrogen of DMSO and the N atom in NA in some complexes (AB5, AB6 and AB7), which cannot be further confirmed by NBO and other methods, so there are probably no interactions between hydrogen and nitrogen atoms among these complexes.	Hydrogen	60-68	NBPF member 10	Homo sapiens	122-125
21805522-6	2011	PXR employs one hydrogen bond and fourteen van der Waals contacts to interact with the ligand, but allows two loops adjacent to the ligand-binding pocket to remain disordered in the structure.	Hydrogen	16-24	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-3
21795045-3	2011	The most potent analogue, 1h, exhibited enhanced antiproliferative activities compared with the parent 1a, and exhibited an IC(50) value against NCI-H460 cells of 4.13 muM compared with 4.52 muM for the positive control cisplatin.	Hydrogen	26-28	latexin	Homo sapiens	168-171
21854046-3	2011	In this article, we use screened hybrid DFT to study intrinsic defects and hydrogen impurities in CdO and identify for the first time the source of charge carriers in this system.	Hydrogen	75-83	cell adhesion associated, oncogene regulated	Homo sapiens	98-101
21700707-7	2011	Moreover, the breathing motions of the SOD1 barrel are overall insensitive to loop removal and yield hydrogen/deuterium protection factors typical for cooperatively folded proteins (i.e. the active-site loops act as a "bolt-on" domain with little dynamic influence on its structural foundation).	Hydrogen	101-109	superoxide dismutase 1	Homo sapiens	39-43
21455516-2	2011	Replacing the hydrogens at the 3-pyrazolyl positions with alkyl groups causes significant distortion to the ligand framework due to potential interactions between these groups when bound to a fac-Re(CO)(3) moiety.	Hydrogen	14-23	FA complementation group C	Homo sapiens	192-195
21757705-3	2011	Using mutant cycle analysis and unnatural residue mutagenesis, including backbone mutagenesis of the peptide bond of the vicinal disulfide, we have established the presence of a network of hydrogen bonds that extends from that peptide NH, across a beta turn to another backbone hydrogen bond, and then across the subunit interface to the side chain of a functionally important Asp residue in the non-alpha subunit.	Hydrogen	189-197	amyloid beta precursor protein	Homo sapiens	246-252
21757705-3	2011	Using mutant cycle analysis and unnatural residue mutagenesis, including backbone mutagenesis of the peptide bond of the vicinal disulfide, we have established the presence of a network of hydrogen bonds that extends from that peptide NH, across a beta turn to another backbone hydrogen bond, and then across the subunit interface to the side chain of a functionally important Asp residue in the non-alpha subunit.	Hydrogen	278-286	amyloid beta precursor protein	Homo sapiens	246-252
21795045-3	2011	The most potent analogue, 1h, exhibited enhanced antiproliferative activities compared with the parent 1a, and exhibited an IC(50) value against NCI-H460 cells of 4.13 muM compared with 4.52 muM for the positive control cisplatin.	Hydrogen	26-28	latexin	Homo sapiens	191-194
21661078-2	2011	The crystal structure revealed that the Pro47-Ser65 moiety of 4E-BP2 adopts a L-shaped conformation involving extended and alpha-helical structures and extends over the N-terminal loop and two different helix regions of eIF4E through hydrogen bonds, and electrostatic and hydrophobic interactions; these features were similarly observed for 4E-BP1.	Hydrogen	234-242	eukaryotic translation initiation factor 4E binding protein 2	Homo sapiens	62-68
21722719-7	2011	Oral GSH (300 mg/kg) administration 1h before CEES exposure attenuated the increase in both CEES-induced H2A.X phosphorylation (59%) as well as expression of COX-2 (68%), iNOS (53%) and MMP-9 (54%).	Hydrogen	36-38	H2A.X variant histone	Mus musculus	105-110
21600763-6	2011	The average hydrogen production rate was 205 mL-H2/L/d.	Hydrogen	12-20	lysine (K)-specific methyltransferase 2A	Mus musculus	45-54
21816515-9	2011	Molecular docking studies using a homology model of the 5-HT(1A) receptor revealed a significant role of the N-8 atom of the tropane core in stabilising the ligand-receptor complex due to strong hydrogen bonding with Asp116 located in the TMH 3 helix.	Hydrogen	195-203	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	56-73
21544615-0	2011	H2 inhibits TNF-alpha-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor kappaB activation in endothelial cells.	Hydrogen	0-2	tumor necrosis factor	Mus musculus	12-21
21816395-8	2011	In particular, hydrophobility, electronic property and hydrogen bond contribute most significantly to the binding affinity of TAP-peptide association.	Hydrogen	55-63	SEC14 like lipid binding 2	Homo sapiens	126-129
21816515-11	2011	In another homology model of the D(2) receptor, strong hydrogen bonding of the amide moiety in the 3beta position of the tropane nucleus with Asp85 was observed.	Hydrogen	55-63	dopamine receptor D2	Mus musculus	33-46
21764125-9	2011	Additionally, hydrogen-rich saline treatment decreased the blood and placental MDA, proteinuria and the pro-inflammatory cytokine TNF-alpha, IL-1beta in the placental tissues compared with those in L-NAME-treated rats (all P &lt; 0.05).	Hydrogen	14-22	tumor necrosis factor	Rattus norvegicus	130-139
21697807-8	2011	Infusion of the pressor dose decreased, whereas the non-pressor dose of angiotensin II increased the phosphorylation of the sodium and hydrogen exchanger 3 (NHE-3) in membrane fractions of proximal tubules.	Hydrogen	135-143	angiotensinogen	Rattus norvegicus	72-86
21796302-9	2011	Intriguingly, the carboxyl group demonstrated different bonding patterns with PDE4D and ALOX5AP, through electrostatic interaction and hydrogen bonds, respectively.	Hydrogen	135-143	arachidonate 5-lipoxygenase activating protein	Homo sapiens	88-95
21764272-9	2011	NGT-1h-high subjects were at increased risk of having AST levels in the highest quartile as compared with NGT-1h-low subjects (OR = 1.51; 95%CI: 1.04-2.22).	Hydrogen	4-6	solute carrier family 17 member 5	Homo sapiens	54-57
21977518-5	2011	Specifically, the increased constraints enhanced resistance to relative conformational changes in the RGD-synergy site in fibronectin, increased the conformational stability of fibronectin, and prevented losses in hydrogen bond occupancy of each beta-strand pair in FN-III10 resulting from external force.	Hydrogen	214-222	fibronectin 1	Homo sapiens	122-133
21764125-9	2011	Additionally, hydrogen-rich saline treatment decreased the blood and placental MDA, proteinuria and the pro-inflammatory cytokine TNF-alpha, IL-1beta in the placental tissues compared with those in L-NAME-treated rats (all P &lt; 0.05).	Hydrogen	14-22	interleukin 1 beta	Rattus norvegicus	141-149
21739987-7	2011	The results indicate that the hydrogen transfer reaction of alpha-TocH proceeds via an electron transfer intermediate from alpha-TocH to ArO( ) radicals followed by proton transfer.	Hydrogen	30-38	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	137-140
21841964-6	2011	We also found that the serine 119 residue of CYP3A4 may serve as a key hydrogen-bonding partner to interact with the 4-amino groups of the studied drugs.	Hydrogen	71-79	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	45-51
21736375-6	2011	Nonionic (hydrogen bonding) interactions make a larger contribution to thrombin binding of SOS than to heparin.	Hydrogen	10-18	coagulation factor II, thrombin	Homo sapiens	71-79
21592827-7	2011	Among the proteins decreased in Add2 knockout RBCs, beta- and alpha-adducin showed the greatest intensity difference, followed by NHE-1 (Slc9a1), the sodium-hydrogen exchanger.	Hydrogen	157-165	adducin 2 (beta)	Mus musculus	32-36
21775152-8	2011	The result of molecular modeling and docking study showed that 3 could bind to the COX-2 active domain well through hydrophobic and hydrogen-bonding interactions, whereas 1 and 2 could not, implying that the hydrolysis of the glycosidic bond of 1 and 2 is a pre-requisite step for their COX-2 inhibitory activity.	Hydrogen	132-140	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-88
21519624-0	2011	A hydrogenase model system based on the sequence of cytochrome c: photochemical hydrogen evolution in aqueous media.	Hydrogen	2-10	cytochrome c, somatic	Homo sapiens	52-64
21806918-2	2011	We used this technique for the site-specific detection of light-induced hydrogen-deuterium exchange in the lipid-embedded heptahelical transmembrane photosensor Anabaena sensory rhodopsin to pinpoint the location of its conformational changes upon activation.	Hydrogen	72-80	rhodopsin	Homo sapiens	178-187
21659526-3	2011	We studied the thermal stability of rhodopsin at 55  C with single point mutations (E181Q and S186A) that perturb the hydrogen-bonding network at the active site.	Hydrogen	118-126	rhodopsin	Homo sapiens	36-45
21659526-5	2011	Our results illustrate the importance of the intact hydrogen-bonding network for dim-light detection, revealing the functional roles of water molecules in rhodopsin.	Hydrogen	52-60	rhodopsin	Homo sapiens	155-164
21514409-6	2011	In healthy humans, single oral doses of ATF936 produced peak PTH levels in plasma after a median time of 1h and levels returned to normal at 24-h post-dose.	Hydrogen	105-107	parathyroid hormone	Homo sapiens	61-64
22146365-12	2011	Conversely, the gene expressions of MMP3 and MMP13 were restoratively down-regulated with H2.	Hydrogen	90-92	matrix metallopeptidase 3	Homo sapiens	36-40
22146365-12	2011	Conversely, the gene expressions of MMP3 and MMP13 were restoratively down-regulated with H2.	Hydrogen	90-92	matrix metallopeptidase 13	Homo sapiens	45-50
21453670-6	2011	SOD1 was eluted with 30% acetonitrile plus 100 muM formic acid to provide sufficient hydrogen ions to ionize the protein without dislodging metals.	Hydrogen	85-93	superoxide dismutase 1	Rattus norvegicus	0-4
21741637-8	2011	In cells exposed for 10min, 1h and 3h to different amounts of PM(10), transcription of TNFalpha and TRAP1, which code for a key pro-inflammatory cytokine and a mitochondrial protein involved in cell protection from oxidative stress, respectively, was shown to be modulated in a time-dependent, but not a dose-dependent manner.	Hydrogen	28-30	tumor necrosis factor	Homo sapiens	87-95
21806784-2	2011	Two of the formate dehydrogenases (Fdh-N and Fdh-O) and two of the hydrogenases (Hyd-1 and Hyd-2) have their respective catalytic subunits located in the periplasm and these enzymes have been shown previously to oxidize formate and hydrogen, respectively, and thus function in energy metabolism.	Hydrogen	21-29	aldehyde dehydrogenase 1 family member L1	Homo sapiens	35-38
21806784-2	2011	Two of the formate dehydrogenases (Fdh-N and Fdh-O) and two of the hydrogenases (Hyd-1 and Hyd-2) have their respective catalytic subunits located in the periplasm and these enzymes have been shown previously to oxidize formate and hydrogen, respectively, and thus function in energy metabolism.	Hydrogen	21-29	aldehyde dehydrogenase 1 family member L1	Homo sapiens	45-48
21806784-9	2011	Analysis of defined mutants devoid of selenocysteine biosynthetic capacity or carrying deletions in the genes encoding the catalytic subunits of Fdh-N and Fdh-O demonstrated that both enzymes catalyze hydrogen activation.	Hydrogen	201-209	aldehyde dehydrogenase 1 family member L1	Homo sapiens	145-148
21806784-9	2011	Analysis of defined mutants devoid of selenocysteine biosynthetic capacity or carrying deletions in the genes encoding the catalytic subunits of Fdh-N and Fdh-O demonstrated that both enzymes catalyze hydrogen activation.	Hydrogen	201-209	aldehyde dehydrogenase 1 family member L1	Homo sapiens	155-158
21806784-10	2011	Fdh-N and Fdh-O can also transfer the electrons derived from oxidation of hydrogen to other redox dyes.	Hydrogen	74-82	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-3
21806784-10	2011	Fdh-N and Fdh-O can also transfer the electrons derived from oxidation of hydrogen to other redox dyes.	Hydrogen	74-82	aldehyde dehydrogenase 1 family member L1	Homo sapiens	10-13
21806784-11	2011	CONCLUSIONS: The related respiratory molybdo-selenoproteins Fdh-N and Fdh-O of Escherichia coli have hydrogen-oxidizing activity.	Hydrogen	101-109	aldehyde dehydrogenase 1 family member L1	Homo sapiens	60-63
21806784-11	2011	CONCLUSIONS: The related respiratory molybdo-selenoproteins Fdh-N and Fdh-O of Escherichia coli have hydrogen-oxidizing activity.	Hydrogen	101-109	aldehyde dehydrogenase 1 family member L1	Homo sapiens	70-73
21806784-12	2011	These findings demonstrate that the energy-conserving selenium- and molybdenum-dependent formate dehydrogenases Fdh-N and Fdh-O exhibit a degree of promiscuity with respect to the electron donor they use and identify a new class of dihydrogen-oxidizing enzyme.	Hydrogen	232-242	aldehyde dehydrogenase 1 family member L1	Homo sapiens	112-115
21806784-12	2011	These findings demonstrate that the energy-conserving selenium- and molybdenum-dependent formate dehydrogenases Fdh-N and Fdh-O exhibit a degree of promiscuity with respect to the electron donor they use and identify a new class of dihydrogen-oxidizing enzyme.	Hydrogen	232-242	aldehyde dehydrogenase 1 family member L1	Homo sapiens	122-125
21621881-1	2011	A validated 3D pharmacophore model was generated for a series of ACE inhibitory peptides, which consisted of five features (two hydrophobic functions, two hydrogen bond acceptors, and a negative ionizable function).	Hydrogen	155-163	angiotensin I converting enzyme	Homo sapiens	65-68
21689084-0	2011	Comparative proteomics reveals deficiency of SLC9A1 (sodium/hydrogen exchanger NHE1) in beta-adducin null red cells.	Hydrogen	60-68	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	45-51
21689084-0	2011	Comparative proteomics reveals deficiency of SLC9A1 (sodium/hydrogen exchanger NHE1) in beta-adducin null red cells.	Hydrogen	60-68	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	79-83
21689084-0	2011	Comparative proteomics reveals deficiency of SLC9A1 (sodium/hydrogen exchanger NHE1) in beta-adducin null red cells.	Hydrogen	60-68	adducin 2 (beta)	Mus musculus	88-100
21689084-7	2011	Of the proteins decreased in Add2 knockout RBCs, alpha-adducin showed the greatest intensity difference, followed by SLC9A1, the sodium-hydrogen exchanger previously termed NHE1.	Hydrogen	136-144	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	117-123
21689084-7	2011	Of the proteins decreased in Add2 knockout RBCs, alpha-adducin showed the greatest intensity difference, followed by SLC9A1, the sodium-hydrogen exchanger previously termed NHE1.	Hydrogen	136-144	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	173-177
21643588-0	2011	Enantioselective binding of a lanthanide(III) complex to human serum albumin studied by 1H STD NMR techniques.	Hydrogen	88-90	albumin	Homo sapiens	63-76
21696230-10	2011	Flap region also exhibited similar behaviour due to changes in number of hydrogen bonds during simulations.	Hydrogen	73-81	arachidonate 5-lipoxygenase activating protein	Homo sapiens	0-4
21699240-4	2011	The first phase transition is attributed to the rearrangements of hydrogen-bonding networks, resulting in the symmetry transformation from P2(1)/c to P1.	Hydrogen	66-74	cyclin dependent kinase inhibitor 1A	Homo sapiens	139-144
21723254-3	2011	In the present study, we examined the hydrogen effects on lipopolysaccharide/interferon gamma LPS/IFNgamma-induced nitric oxide (NO) production in murine macrophage RAW264 cells.	Hydrogen	38-46	toll-like receptor 4	Mus musculus	94-97
21723254-3	2011	In the present study, we examined the hydrogen effects on lipopolysaccharide/interferon gamma LPS/IFNgamma-induced nitric oxide (NO) production in murine macrophage RAW264 cells.	Hydrogen	38-46	interferon gamma	Mus musculus	98-106
21723254-4	2011	Treatment with hydrogen reduced LPS/IFNgamma-induced NO release, which was associated with a diminished induction of inducible isoform of nitric oxide synthase (iNOS).	Hydrogen	15-23	toll-like receptor 4	Mus musculus	32-35
21723254-4	2011	Treatment with hydrogen reduced LPS/IFNgamma-induced NO release, which was associated with a diminished induction of inducible isoform of nitric oxide synthase (iNOS).	Hydrogen	15-23	interferon gamma	Mus musculus	36-44
21723254-4	2011	Treatment with hydrogen reduced LPS/IFNgamma-induced NO release, which was associated with a diminished induction of inducible isoform of nitric oxide synthase (iNOS).	Hydrogen	15-23	nitric oxide synthase 2, inducible	Mus musculus	161-165
21723254-5	2011	Hydrogen treatment inhibited LPS/IFNgamma-induced phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) and its downstream signaling molecules, p38 MAP kinase and JNK, as well as IkappaBalpha, but did not affect activation of NADPH oxidase and production of reactive oxygen species (ROS).	Hydrogen	0-8	toll-like receptor 4	Mus musculus	29-32
21723254-5	2011	Hydrogen treatment inhibited LPS/IFNgamma-induced phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) and its downstream signaling molecules, p38 MAP kinase and JNK, as well as IkappaBalpha, but did not affect activation of NADPH oxidase and production of reactive oxygen species (ROS).	Hydrogen	0-8	interferon gamma	Mus musculus	33-41
21723254-5	2011	Hydrogen treatment inhibited LPS/IFNgamma-induced phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) and its downstream signaling molecules, p38 MAP kinase and JNK, as well as IkappaBalpha, but did not affect activation of NADPH oxidase and production of reactive oxygen species (ROS).	Hydrogen	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	188-200
21570330-6	2011	The key hydrogen bonding residues between hAChE and hCyt c proteins were found in Apo and Holo systems, as well as each Tyr341 and Trp286 residue of hAChE was participated in cation-pi (pi) interactions with Lys79 of hCyt c in Apo and Holo systems, respectively.	Hydrogen	8-16	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-47
21570330-6	2011	The key hydrogen bonding residues between hAChE and hCyt c proteins were found in Apo and Holo systems, as well as each Tyr341 and Trp286 residue of hAChE was participated in cation-pi (pi) interactions with Lys79 of hCyt c in Apo and Holo systems, respectively.	Hydrogen	8-16	acetylcholinesterase (Cartwright blood group)	Homo sapiens	149-154
21723254-9	2011	Taken together, our studies indicate that hydrogen inhibits LPS/IFNgamma-induced NO production through modulation of signal transduction in macrophages and ameliorates inflammatory arthritis in mice, providing the molecular basis for hydrogen effects on inflammation and a functional interaction between two gaseous signaling molecules, NO and molecular hydrogen.	Hydrogen	42-50	toll-like receptor 4	Mus musculus	60-63
21723254-9	2011	Taken together, our studies indicate that hydrogen inhibits LPS/IFNgamma-induced NO production through modulation of signal transduction in macrophages and ameliorates inflammatory arthritis in mice, providing the molecular basis for hydrogen effects on inflammation and a functional interaction between two gaseous signaling molecules, NO and molecular hydrogen.	Hydrogen	42-50	interferon gamma	Mus musculus	64-72
21723254-9	2011	Taken together, our studies indicate that hydrogen inhibits LPS/IFNgamma-induced NO production through modulation of signal transduction in macrophages and ameliorates inflammatory arthritis in mice, providing the molecular basis for hydrogen effects on inflammation and a functional interaction between two gaseous signaling molecules, NO and molecular hydrogen.	Hydrogen	234-242	toll-like receptor 4	Mus musculus	60-63
21723254-9	2011	Taken together, our studies indicate that hydrogen inhibits LPS/IFNgamma-induced NO production through modulation of signal transduction in macrophages and ameliorates inflammatory arthritis in mice, providing the molecular basis for hydrogen effects on inflammation and a functional interaction between two gaseous signaling molecules, NO and molecular hydrogen.	Hydrogen	234-242	interferon gamma	Mus musculus	64-72
21723254-9	2011	Taken together, our studies indicate that hydrogen inhibits LPS/IFNgamma-induced NO production through modulation of signal transduction in macrophages and ameliorates inflammatory arthritis in mice, providing the molecular basis for hydrogen effects on inflammation and a functional interaction between two gaseous signaling molecules, NO and molecular hydrogen.	Hydrogen	234-242	toll-like receptor 4	Mus musculus	60-63
21723254-9	2011	Taken together, our studies indicate that hydrogen inhibits LPS/IFNgamma-induced NO production through modulation of signal transduction in macrophages and ameliorates inflammatory arthritis in mice, providing the molecular basis for hydrogen effects on inflammation and a functional interaction between two gaseous signaling molecules, NO and molecular hydrogen.	Hydrogen	234-242	interferon gamma	Mus musculus	64-72
21678955-1	2011	The transient titanium alkylidyne, (PNP)Ti C(t)Bu (PNP = N[2-P(i)Pr(2)-4-methylphenyl](2)(-)), activates a C-H bond of ethane at room temperature, and a beta-hydrogen of the resulting ethyl ligand is subsequently transferred to the adjacent alkylidene ligand to form an ethylene adduct of titanium.	Hydrogen	158-166	amyloid beta precursor protein	Homo sapiens	151-157
21606109-8	2011	This suggests that LCCAs and some other uncouplers may act through the formation of hydrogen bonds with the as-of-yet unidentified histidine/s of the Cx45 GJ channel protein.	Hydrogen	84-92	gap junction protein gamma 1	Homo sapiens	150-154
21415010-7	2011	Based on mutational analysis and hydrogen/deuterium-exchange mass-spectrometry data, a model of JBP1 bound to J-DNA was constructed and validated by small-angle X-ray scattering data.	Hydrogen	33-41	protein arginine methyltransferase 5	Homo sapiens	96-100
21914363-7	2011	RESULTS: The minimal expressions of IL-6, p-STAT3, cyclin D1 and DNA binding activity of STAT3 were detected in OLT-1h group.	Hydrogen	116-118	interleukin 6	Rattus norvegicus	36-40
21574570-6	2011	When the buried water molecules were removed prior to a second 10 ns simulation, beta4 and beta5 formed persistent hydrogen bonds identical to those in rCYB5B, but the Leu21 side chain was forced to adopt a rarely observed conformation.	Hydrogen	115-123	adaptor related protein complex 4 subunit beta 1	Homo sapiens	81-86
21413771-4	2011	We find structural trends similar to those in phenylalanine-glycine-glycine (FGG) and tryptophan-glycine-glycine (WGG); however, the effect of dispersive forces in FGG for stabilizing a folded structure is replaced by that of hydrogen bonding in YGG.	Hydrogen	226-234	fibrinogen gamma chain	Homo sapiens	164-167
21574570-3	2011	The greater bulk of Leu21 in hCYB5B in comparison to that of Thr21 in rCYB5B results in a substantial displacement of the first two residues in beta5, and consequent loss of two of the three hydrogen bonds between beta5 and beta4.	Hydrogen	191-199	cytochrome b5 type B	Homo sapiens	29-35
21574570-3	2011	The greater bulk of Leu21 in hCYB5B in comparison to that of Thr21 in rCYB5B results in a substantial displacement of the first two residues in beta5, and consequent loss of two of the three hydrogen bonds between beta5 and beta4.	Hydrogen	191-199	cytochrome b5 type B	Rattus norvegicus	70-76
21488623-5	2011	The formation of microtubes was attributed to the formation of hydrogen bonding networks between the lysozyme molecules.	Hydrogen	63-71	lysozyme	Homo sapiens	101-109
21914363-7	2011	RESULTS: The minimal expressions of IL-6, p-STAT3, cyclin D1 and DNA binding activity of STAT3 were detected in OLT-1h group.	Hydrogen	116-118	cyclin D1	Rattus norvegicus	51-60
21426301-4	2011	We find that in the active conformation of the ErbB kinases, key subdomain motions are co-ordinated through conserved hydrophilic interactions: activating bond-networks consisting of hydrogen bonds and salt bridges.	Hydrogen	183-191	epidermal growth factor receptor	Homo sapiens	47-51
21641324-3	2011	We demonstrate that strong electrostatic repulsion is sufficient to disrupt the hydrogen-bonded, cross-beta network that links insulin molecules and ultimately results in fibril dissociation.	Hydrogen	80-88	insulin	Homo sapiens	127-134
21645859-2	2011	We investigated hydrogen/deuterium (H/D)-exchange within the extracellular domain of the type-I insulin-like growth factor receptor (IGF-1R) in the absence and presence of IGF-1 (active state) and in the presence of antibody inhibitors (inactive state).	Hydrogen	16-24	insulin like growth factor 1	Homo sapiens	133-138
21478159-4	2011	Based on the crystal structure of the Cx26 gap junction channel and homology models of heterotypic channels, we analyzed docking selectivity for several hemichannel pairs and found that the hydrogen bonds between E2 domains are conserved in a group of heterotypically compatible hemichannels, including Cx26 and Cx32 hemichannels.	Hydrogen	190-198	gap junction protein beta 2	Homo sapiens	38-42
21478159-4	2011	Based on the crystal structure of the Cx26 gap junction channel and homology models of heterotypic channels, we analyzed docking selectivity for several hemichannel pairs and found that the hydrogen bonds between E2 domains are conserved in a group of heterotypically compatible hemichannels, including Cx26 and Cx32 hemichannels.	Hydrogen	190-198	gap junction protein beta 2	Homo sapiens	303-307
21446712-3	2011	Therefore, we hypothesized that the binding of P4 and 17OHP4 to CYP21A2 restricts access of the reactive heme-oxygen complex to the C-21 hydrogen atoms, suppressing oxygenation at kinetically more favorable sites such as C-17 and C-16, which are both hydroxylated by cytochrome P450c17 (CYP17A1).	Hydrogen	137-145	TBL1X/Y related 1	Homo sapiens	132-136
20839017-2	2011	The energies of the frontier orbitals and the distances between the more acidic hydrogen species were investigated to determine their contributions to the activity of a group of acetylcholinesterase inhibitors.	Hydrogen	80-88	acetylcholinesterase (Cartwright blood group)	Homo sapiens	178-198
20839017-7	2011	Desirable features for acetylcholinesterase inhibitor molecules include aromatic systems or groups that simulate the surface electrostatic potential of aromatic systems and the presence of a sufficient number of hydrogen acceptors and few hydrogen donors.	Hydrogen	212-220	acetylcholinesterase (Cartwright blood group)	Homo sapiens	23-43
20839017-7	2011	Desirable features for acetylcholinesterase inhibitor molecules include aromatic systems or groups that simulate the surface electrostatic potential of aromatic systems and the presence of a sufficient number of hydrogen acceptors and few hydrogen donors.	Hydrogen	239-247	acetylcholinesterase (Cartwright blood group)	Homo sapiens	23-43
21467044-1	2011	Mass spectrometry-based hydrogen/deuterium exchange (H/DX) has been used to define the polypeptide backbone dynamics of full-length methyl CpG binding protein 2 (MeCP2) when free in solution and when bound to unmethylated and methylated DNA.	Hydrogen	24-32	methyl-CpG binding protein 2	Homo sapiens	132-160
21467044-1	2011	Mass spectrometry-based hydrogen/deuterium exchange (H/DX) has been used to define the polypeptide backbone dynamics of full-length methyl CpG binding protein 2 (MeCP2) when free in solution and when bound to unmethylated and methylated DNA.	Hydrogen	24-32	methyl-CpG binding protein 2	Homo sapiens	162-167
21454623-0	2011	Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS).	Hydrogen	113-121	Rap guanine nucleotide exchange factor 4	Homo sapiens	39-44
21430053-7	2011	The docking of TSC in the crystal structure of the BVDV RdRp revealed a close contact between the indane ring of the compound and several residues within the fingers domain of the enzyme, some hydrophobic contacts, and hydrogen bonds with the thiosemicarbazone group.	Hydrogen	219-227	TSC complex subunit 1	Homo sapiens	15-18
21446712-6	2011	Molecular dynamics simulations indicate that binding of the steroid nucleus perpendicular to the plane of the CYP21A2 heme ring limits access of the heme oxygen to the C-21 hydrogen atoms.	Hydrogen	173-181	TBL1X/Y related 1	Homo sapiens	168-172
21536907-4	2011	To understand the structural organization of the LysRS-p38 complex that regulates LysRS mobilization, we investigated the complex by use of small angle X-ray scattering and hydrogen-deuterium exchange with mass spectrometry in solution.	Hydrogen	173-181	lysyl-tRNA synthetase 1	Homo sapiens	49-54
21536907-4	2011	To understand the structural organization of the LysRS-p38 complex that regulates LysRS mobilization, we investigated the complex by use of small angle X-ray scattering and hydrogen-deuterium exchange with mass spectrometry in solution.	Hydrogen	173-181	mitogen-activated protein kinase 14	Homo sapiens	55-58
21572885-0	2011	The importance of ARG513 as a hydrogen bond anchor to discover COX-2 inhibitors in a virtual screening campaign.	Hydrogen	30-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	63-68
21623316-4	2011	THTP-C has a "saddle" shaped pi-conjugated 1-D supramolecular structure, and favors highly ordered self-assembly by pi-pi interactions as evidenced by its concentration-dependent 1H-NMR spectra in solution.	Hydrogen	179-181	thiamine triphosphatase	Homo sapiens	0-4
21507633-4	2011	X-ray structures of the inhibitor/Pim-1 binding complex reveal important salt-bridge and hydrogen bond interactions mediated by the compound"s carboxylic acid and amino groups.	Hydrogen	89-97	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
21474311-7	2011	In addition, the structural analysis of compound 4 suggested hydrogen bond interactions between compound 4 and Ala 1950 residue in the backbone of the ATP binding pocket of LRRK2 kinas domain.	Hydrogen	61-69	leucine rich repeat kinase 2	Homo sapiens	173-178
21473852-0	2011	Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation.	Hydrogen	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	109-131
21473852-6	2011	Hydrogen gas inhalation increased NFkappaB DNA binding after 1h of ventilation and decreased NFkappaB DNA binding after 2h of ventilation, as compared with controls.	Hydrogen	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	34-42
21473852-6	2011	Hydrogen gas inhalation increased NFkappaB DNA binding after 1h of ventilation and decreased NFkappaB DNA binding after 2h of ventilation, as compared with controls.	Hydrogen	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-101
21473852-6	2011	Hydrogen gas inhalation increased NFkappaB DNA binding after 1h of ventilation and decreased NFkappaB DNA binding after 2h of ventilation, as compared with controls.	Hydrogen	61-63	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	34-42
21473852-7	2011	The early activation of NFkappaB during hydrogen treatment was correlated with elevated levels of the antiapoptotic protein Bcl-2 and decreased levels of Bax.	Hydrogen	40-48	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	24-32
21473852-7	2011	The early activation of NFkappaB during hydrogen treatment was correlated with elevated levels of the antiapoptotic protein Bcl-2 and decreased levels of Bax.	Hydrogen	40-48	B cell leukemia/lymphoma 2	Mus musculus	124-129
21295102-8	2011	The Bax/Bcl-2 ratio increased significantly after 1h pretreatment with curcumin.	Hydrogen	50-52	BCL2, apoptosis regulator	Rattus norvegicus	8-13
21473852-10	2011	NFkappaB activation and an associated increase in the expression of Bcl-2 may contribute, in part, to the cytoprotective effects of hydrogen against apoptotic and inflammatory signaling pathway activation during VILI.	Hydrogen	132-140	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-8
21473852-10	2011	NFkappaB activation and an associated increase in the expression of Bcl-2 may contribute, in part, to the cytoprotective effects of hydrogen against apoptotic and inflammatory signaling pathway activation during VILI.	Hydrogen	132-140	B cell leukemia/lymphoma 2	Mus musculus	68-73
21486030-2	2011	By monitoring hydrogen/deuterium exchange in Abeta fibrils using electrospray ionization mass spectrometry, we demonstrate that the Abeta molecules comprising the fibril continuously dissociate and reassociate, resulting in molecular recycling within the fibril population.	Hydrogen	14-22	amyloid beta precursor protein	Homo sapiens	132-137
20872830-10	2011	Molecular modeling of the lesions in the NF-kappaB sequence indicated that 8-oxo-dAdo may form an additional hydrogen bond with the protein, thereby strengthening the binding of NF-kappa B to its DNA target.	Hydrogen	109-117	nuclear factor kappa B subunit 1	Homo sapiens	178-188
21388519-6	2011	A Tyr residue within the CLIC4 NLS makes surprisingly favourable interactions by forming side-chain hydrogen bonds to the importin-alpha backbone.	Hydrogen	100-108	chloride intracellular channel 4	Homo sapiens	25-30
21482800-2	2011	The ice-binding site of an AFP is relatively hydrophobic, but also contains many potential hydrogen bond donors/acceptors.	Hydrogen	91-99	alpha fetoprotein	Homo sapiens	27-30
21482800-5	2011	This 34-kDa domain, the largest AFP structure determined to date, folds as a Ca(2+)-bound parallel beta-helix with an extensive array of ice-like surface waters that are anchored via hydrogen bonds directly to the polypeptide backbone and adjacent side chains.	Hydrogen	183-191	alpha fetoprotein	Homo sapiens	32-35
21482800-7	2011	This unobstructed view, free from crystal-packing artefacts, shows the contributions of both the hydrophobic effect and hydrogen bonding during AFP adsorption to ice.	Hydrogen	120-128	alpha fetoprotein	Homo sapiens	144-147
21486030-2	2011	By monitoring hydrogen/deuterium exchange in Abeta fibrils using electrospray ionization mass spectrometry, we demonstrate that the Abeta molecules comprising the fibril continuously dissociate and reassociate, resulting in molecular recycling within the fibril population.	Hydrogen	14-22	amyloid beta precursor protein	Homo sapiens	45-50
21376023-6	2011	miR-23 a/b was detected down-regulated at 0 h, 1h, 6h, 12h, 2 days, 7 days, 10 days, 30 days after SE and significantly up-regulated at 24h (4.49 folds P&lt;0.01), 50 d (2.4 folds, P&lt;0.01) after SE.	Hydrogen	47-49	microRNA 23a	Rattus norvegicus	0-8
20080260-9	2011	RESULTS: Creatinine, MDA, IL-1beta, and IL-6 levels were significantly higher in group 3, 1h after the reperfusion period compared with the control group, and the same parameters were significantly lower in the groups in which doxycycline was administered, 1 hour after decompression.	Hydrogen	90-92	interleukin 6	Rattus norvegicus	40-44
21345721-4	2011	Negative values of DeltaG, DeltaH, and DeltaS indicate that the interaction between SAS and BSA is driven by hydrogen bonds and van der Waals forces.	Hydrogen	109-117	albumin	Homo sapiens	92-95
20628775-7	2011	Using energy, hydrogen bond and solvent accessible surface analyses, we identified a series of key residues that may be involved in the Grp78:E2s interaction.	Hydrogen	14-22	heat shock protein family A (Hsp70) member 5	Homo sapiens	136-141
21460846-5	2011	Fluorescence and hydrogen-exchange measurements support a loosening of the structure of p53 in the presence of Hsp90 and its domains.	Hydrogen	17-25	tumor protein p53	Homo sapiens	88-91
21239147-6	2011	The 2D plot of PC2 vs. PC1 showed adequate separation of the CH(3), CH(2), CH and C cases (C stands for carbons without adjacent hydrogens).	Hydrogen	129-138	polycystin 2, transient receptor potential cation channel	Homo sapiens	15-18
21239147-6	2011	The 2D plot of PC2 vs. PC1 showed adequate separation of the CH(3), CH(2), CH and C cases (C stands for carbons without adjacent hydrogens).	Hydrogen	129-138	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	23-26
21273024-11	2011	Molecular modeling studies confirmed the presence of fluorophore residues, hydrogen bonding and electrostatic interactions at the interface of the HSA-TF complex.	Hydrogen	75-83	albumin	Homo sapiens	147-150
21481777-4	2011	Here, we used hydrogen exchange mass spectrometry to examine the solution dynamics of the Notch1 negative regulatory region in autoinhibited states before and after S1 cleavage, in a proteolytically sensitive "on" state, and in a complex with an inhibitory antibody.	Hydrogen	14-22	notch receptor 1	Homo sapiens	90-96
21052876-0	2011	1H, 13C and 15N chemical shift assignments for the human Pitx2 homeodomain and a R24H homeodomain mutant.	Hydrogen	0-2	paired like homeodomain 2	Homo sapiens	57-62
20711761-0	2011	1H, 13C, and 15N chemical shift assignments of ZCCHC9.	Hydrogen	0-2	zinc finger CCHC-type containing 9	Homo sapiens	47-53
21252044-1	2011	NHE8, the newest member of the sodium/hydrogen exchanger family, is expressed in the epithelial cells of the intestine and the kidney.	Hydrogen	38-46	solute carrier family 9 (sodium/hydrogen exchanger), member 8	Mus musculus	0-4
21282450-8	2011	Modeling analyses revealed that GRL-1398 had greater overall hydrogen bonding and hydrophobic interactions than GRL-1388 and DRV and that GRL-1388 and -1398 had hydrogen bonding interactions with the main chain of the active-site amino acids (Asp29 and Asp30) of protease.	Hydrogen	61-69	nuclear receptor subfamily 3 group C member 1	Homo sapiens	32-35
21185343-6	2011	In the Cx, the GIPR expression increases after 1h, 12h and 5 days, but not 50 days after the Pilo-SE.	Hydrogen	47-49	gastric inhibitory polypeptide receptor	Homo sapiens	15-19
21650011-2	2011	The identity of the substance under study (labelled as UPB-1) was confirmed by 1H- and 13C-NMR spectra as well as IR spectrometry.	Hydrogen	79-81	beta-ureidopropionase 1	Homo sapiens	55-60
21172351-8	2011	Recombinant Ac-HSB-1 immunoprecipitated Ce-HSF-1 expressed in mammalian cells that had been heat shocked for 1h at 42 C, but not from cells incubated at 37 C, indicating that HSB-1 only bound to the active DNA binding form of HSF-1.	Hydrogen	109-111	SH3 domain containing kinase binding protein 1	Homo sapiens	15-20
21172351-9	2011	Expression of Ac-hsb-1 transcripts decreased following 1h of heat shock, but increased when L3s were incubated at 37 C for 1h.	Hydrogen	55-57	SH3 domain containing kinase binding protein 1	Homo sapiens	17-22
21172351-9	2011	Expression of Ac-hsb-1 transcripts decreased following 1h of heat shock, but increased when L3s were incubated at 37 C for 1h.	Hydrogen	123-125	SH3 domain containing kinase binding protein 1	Homo sapiens	17-22
20737253-0	2011	Backbone and side chain 1H, 15N and 13C assignments of the KSR1 CA1 domain.	Hydrogen	24-26	kinase suppressor of ras 1	Mus musculus	59-63
21200321-8	2011	Hydrogen-rich saline treatment significantly reduced the level of degraded myelin basic protein, decreased the expression of ionized calcium-binding adapter molecule 1, Iba1, a microglial marker, reduced DNA oxidation, and suppressed proinflammatory cytokine interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in the cortex and hippocampal tissues when compared with those in normal saline-treated rats.	Hydrogen	0-8	interleukin 1 beta	Rattus norvegicus	259-276
21200321-8	2011	Hydrogen-rich saline treatment significantly reduced the level of degraded myelin basic protein, decreased the expression of ionized calcium-binding adapter molecule 1, Iba1, a microglial marker, reduced DNA oxidation, and suppressed proinflammatory cytokine interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in the cortex and hippocampal tissues when compared with those in normal saline-treated rats.	Hydrogen	0-8	interleukin 6	Rattus norvegicus	278-324
21765645-9	2011	However, hydrogen exchange reveals complete loss of protection in plasma alpha(1)-AT above 1 M GuHCl, similar to what is seen for the recombinant form.	Hydrogen	9-17	serpin family A member 1	Homo sapiens	73-84
21186391-1	2011	A hydrogen bond network has been identified that adjusts protein-substrate contacts in cytochrome P450(cam) (CYP101A1).	Hydrogen	2-10	calmodulin 3	Homo sapiens	87-107
21371829-1	2011	Cyclooxygenase-2 (COX-2) is a prostaglandin synthase that catalyzes the synthesis of prostaglandin G2 and H2.	Hydrogen	106-108	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
21354800-12	2011	The exchange of a 3-methoxy group by an OH-group acting also as a hydrogen bond donor, resulted in decrease in activity underlining the potential role of the hydrogen bond acceptor 3-OCH(3) for the interaction with BCRP.	Hydrogen	66-74	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	215-219
21354800-12	2011	The exchange of a 3-methoxy group by an OH-group acting also as a hydrogen bond donor, resulted in decrease in activity underlining the potential role of the hydrogen bond acceptor 3-OCH(3) for the interaction with BCRP.	Hydrogen	158-166	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	215-219
21117944-7	2011	All the herbal compounds tested can be readily docked into the ligand-binding cavity of PXR mainly through hydrogen bond and aromatic interactions with Ser247, Gln285, His407, and Arg401.	Hydrogen	107-115	nuclear receptor subfamily 1 group I member 2	Homo sapiens	88-91
21371829-1	2011	Cyclooxygenase-2 (COX-2) is a prostaglandin synthase that catalyzes the synthesis of prostaglandin G2 and H2.	Hydrogen	106-108	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
21259066-4	2011	Herein, molecular dynamics simulations, approximate free energy calculations and hydrogen bond energy calculations were integrated together to uncover the structure-activity relationships of this type of PPO inhibitors.	Hydrogen	81-89	protoporphyrinogen oxidase	Homo sapiens	204-207
21292272-6	2011	The LFER results showed that hydrogen bond acidity and polarity/polarizibility have the greatest impact on retention and enantioresolution on the RN CF6 CSP.	Hydrogen	29-37	ATP synthase peripheral stalk subunit F6	Homo sapiens	149-152
21240398-0	2011	Deuterium kinetic isotope effects on the gas-phase reactions of C2H with H2(D2) and CH4(CD4).	Hydrogen	73-75	CD4 molecule	Homo sapiens	88-91
21243153-0	2011	Product formation in rhodopsin by fast hydrogen motions.	Hydrogen	39-47	rhodopsin	Homo sapiens	21-30
21145880-8	2011	Secondly, the favorable hydrophobic interactions, mostly through aromatic pi-pi interactions, and the presence of suitable hydrogen bond(s) between the compounds and PXR are attributes of strong binders.	Hydrogen	123-131	nuclear receptor subfamily 1 group I member 2	Homo sapiens	166-169
20868722-6	2011	Three-dimensional model of Dug1p is constructed and docking of peptides to the modeled structure suggests that hydrogen bonding to active site residues (E172, E171, and D137) lock the N-terminal of the peptide into the binding site.	Hydrogen	111-119	metallodipeptidase	Saccharomyces cerevisiae S288C	27-32
21394223-6	2011	The intrinsic KIE of AA radical formation by C13 pro-(S) hydrogen abstraction in PGHS-1 was estimated to be 1.9-2.3 using rapid freeze-quench EPR kinetic analysis of anaerobic reactions and computer modeling to a mechanism that includes slow formation of a pentadienyl AA radical and rapid equilibration of the AA radical with a tyrosyl radical, NS1c.	Hydrogen	57-65	prostaglandin-endoperoxide synthase 1	Homo sapiens	81-87
21163906-8	2011	PFOA, PFNA, PFDA, and PFOS all efficiently docked with ERalpha from different species and formed a hydrogen bond at residue Arg394/398/407 (human/mouse/trout) in a manner similar to the environmental estrogens bisphenol A and nonylphenol.	Hydrogen	99-107	estrogen receptor 1	Homo sapiens	55-62
21626786-2	2011	All of them were new compounds, and their structures were confirmed by 1H NMR and HR-MS. Three compounds exhibited higher agonistic activities of PPARgamma than that of the comparison, six compounds exhibited higher agonistic activities of PPARalpha than that of the comparison, and compound 8a was discovered as a highly potent PPARalpha/gamma agonist that is much more active than that of WY14643 and rosiglitazone.	Hydrogen	71-73	peroxisome proliferator activated receptor gamma	Homo sapiens	146-155
21341853-3	2011	Although the hydrogen bond energy and the distance of the nearest-neighbor oxygen pair are significantly different for TIP4P and GCP models, they approach to similar ground state structures and melting transition temperatures in cluster sizes we considered.	Hydrogen	13-21	golgin B1	Homo sapiens	129-132
21269826-0	2011	Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.	Hydrogen	34-42	mechanistic target of rapamycin kinase	Homo sapiens	76-80
21269826-1	2011	Intra-molecular hydrogen bonding was introduced to the quinazoline motif to form a pseudo ring (intra-molecular H-bond scaffold, iMHBS) to mimic our previous published core structures, pyrido[2.3-D]pyrimidin-7-one and pteridinone, as PI3K/mTOR dual inhibitors.	Hydrogen	16-24	mechanistic target of rapamycin kinase	Homo sapiens	239-243
21269826-2	2011	This design results in potent PI3K/mTOR dual inhibitors and the purposed intra-molecular hydrogen bonding structure is well supported by co-crystal structure in PI3Kgamma enzyme.	Hydrogen	89-97	mechanistic target of rapamycin kinase	Homo sapiens	35-39
21103538-6	2011	Fluorescence line narrowed spectra of the POR-bound Pchlide reveal a C=O keto group downshifted by more than 20 cm(-1) to a relatively low vibrational frequency of 1653 cm(-1), as compared to the unbound Pchlide, indicating that binding of the chromophore to the protein occurs via strong hydrogen bond(s).	Hydrogen	289-297	cytochrome p450 oxidoreductase	Homo sapiens	42-45
21093454-9	2011	Additionally, the peptide preferably interacts with hLysRS over eLysRS including strong hydrogen bond interactions between R247-Q219 and R241-E212.	Hydrogen	88-96	lysyl-tRNA synthetase 1	Homo sapiens	52-58
21165604-8	2011	1H-NMR spectra provide evidence for SPB and SA-1 consumption (A-5(2X) and NPA keep unchanged along the process) and the growth of some products from SA-1 degradation can be followed.	Hydrogen	0-2	stromal antigen 1	Homo sapiens	44-48
21268201-0	2011	The hydrogen-enriched Al-B-N system as an advanced solid hydrogen-storage candidate.	Hydrogen	4-12	albumin	Homo sapiens	22-26
21268201-0	2011	The hydrogen-enriched Al-B-N system as an advanced solid hydrogen-storage candidate.	Hydrogen	57-65	albumin	Homo sapiens	22-26
21142150-6	2011	Results showed that mutation of residues 24 and 32 to Ala in TSP1 and of amino acids 24-26 and 32-34 to Ala in CRT results in a shortened beta-strand in the binding site, decreased hydrogen bond occupancy for beta-strand pairs that are located within or near the binding site, increased conformational flexibility of the binding site, a changed degree of dynamically correlated motion between the residues in the binding site and the other residues in protein, and a changed degree of overall correlated motion between the residues in the protein.	Hydrogen	181-189	thrombospondin 1	Homo sapiens	61-65
21142150-6	2011	Results showed that mutation of residues 24 and 32 to Ala in TSP1 and of amino acids 24-26 and 32-34 to Ala in CRT results in a shortened beta-strand in the binding site, decreased hydrogen bond occupancy for beta-strand pairs that are located within or near the binding site, increased conformational flexibility of the binding site, a changed degree of dynamically correlated motion between the residues in the binding site and the other residues in protein, and a changed degree of overall correlated motion between the residues in the protein.	Hydrogen	181-189	calreticulin	Homo sapiens	111-114
21320803-3	2011	One more methene group in the side chain of Q64 of hCA VII makes it possible to form the hydrogen bond with the bromide atom of the known inhibitor.	Hydrogen	89-97	carbonic anhydrase 7	Homo sapiens	51-58
21320803-5	2011	The complex conformations of the new designed inhibitor and two isozymes designate the formation of the hydrogen bond between the newly added group (hydroxypropyl group) and Q64 of hCA VII but N67 of hCA II.	Hydrogen	104-112	carbonic anhydrase 7	Homo sapiens	181-188
21126552-6	2011	The hydroxyl amino acid residue at position 13 in mammalian PYY and PP molecules could lower conformational plasticity and the non-selective binding via intrachain hydrogen bonding.	Hydrogen	164-172	familial progressive hyperpigmentation 1	Homo sapiens	68-70
21208159-12	2011	Resveratrol (10-50 microM) inhibited phosphorylation of the serine/threonine kinase Akt, by Western blot (15 min, 1h) with a prolonged inhibition (24h) for 25 microM.	Hydrogen	114-116	AKT serine/threonine kinase 1	Homo sapiens	84-87
20977906-2	2011	Stimulated sodium absorption by these solutions is mediated by the Na(+)/H(+) hydrogen exchanger NHE3 and is increased by Na(+)-glucose co-transport in vitro, but the mechanisms of this up-regulated process are only partially understood.	Hydrogen	78-86	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	97-101
20718051-8	2011	The affinities for HSA increased with increasing partition coefficients and decreased with increasing hydrogen bond donor and acceptor numbers of flava(o)noids, which suggested that the binding interaction was mainly caused by hydrophobic forces.	Hydrogen	102-110	albumin	Homo sapiens	19-22
21168411-2	2011	This perdeuterated neutron structure of the Toho-1 R274N/R276N reveals the clearest picture yet of the ground-state active site protonation states and the complete hydrogen-bonding network in a beta-lactamase enzyme.	Hydrogen	164-172	amyloid beta precursor protein	Homo sapiens	192-198
21152624-4	2011	[Co(II)-L(2)-Ln(III)] (18-25) series exhibit 2D open frameworks based on double-stranded helical motifs, which are further assembled into 3D porous structures by intermolecular hydrogen bonds between hydroxyl groups.	Hydrogen	177-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	1-7
21080683-0	2011	Characterization of the estradiol-binding site structure of human pancreas-specific protein disulfide isomerase: indispensable role of the hydrogen bond between His278 and the estradiol 3-hydroxyl group.	Hydrogen	139-147	protein disulfide isomerase family A member 2	Homo sapiens	66-111
21215642-8	2011	The docking results confirmed the apparent influence of pi-pi or cation-pi interactions and hydrogen bonding for reactivator binding within the hAChE active site cleft.	Hydrogen	92-100	acetylcholinesterase (Cartwright blood group)	Homo sapiens	144-149
21080683-6	2011	The hydrogen bond, formed between the 3-hydroxyl group of E(2) (donor) and PDIp"s His278 (acceptor), is indispensable for its binding.	Hydrogen	4-12	protein disulfide isomerase family A member 2	Homo sapiens	75-79
21190667-0	2011	Investigating the refolding pathway of human acidic fibroblast growth factor (hFGF-1) from the residual structure(s) obtained by denatured-state hydrogen/deuterium exchange.	Hydrogen	145-153	fibroblast growth factor 1	Homo sapiens	78-84
21220120-4	2011	RbBP5 engages in several hydrogen bonds and van der Waals contacts within a V-shaped cleft formed by the junction of two blades on WDR5.	Hydrogen	25-33	RB binding protein 5, histone lysine methyltransferase complex subunit	Homo sapiens	0-5
21190667-2	2011	We directly measured hydrogen/deuterium exchange rates on the urea-denatured hFGF-1 to obtain the information with regard to the persistent residual interaction(s) in the unfolded hFGF-1.	Hydrogen	21-29	fibroblast growth factor 1	Homo sapiens	77-83
21126876-2	2011	The in vitro biological evaluation of the title compounds led to the identification of compound 1h, which has good inhibitory activity against T-type calcium channel (IC(50) = 0.83 muM).	Hydrogen	96-98	latexin	Homo sapiens	181-184
22102777-7	2011	Docking results showed hydrogen bond (H-bond) interaction with Lys69 residue lying in the anti-coagulant loop of D. russelli"s venom PLA(2), which is essential in the catalytic activity of the enzyme and hydrophobic interactions with the residues at the binding site (His48, Asp49).	Hydrogen	23-31	phospholipase A2 group IB	Homo sapiens	133-139
21062339-7	2011	In HS group, GCF and serum IL-6 were positively correlated with BOP% and TC/HDL.	Hydrogen	3-5	interleukin 6	Homo sapiens	27-31
21035435-5	2011	LL-37 secretion increased immediately (1h) after exposure to 20muM Zn (0.29+-0.04ng/mL), which continued up to 48h of exposure (0.58+-0.05ng/mL).	Hydrogen	39-41	cathelicidin antimicrobial peptide	Homo sapiens	0-5
20938765-1	2011	PURPOSE: To assess the clinical utility of a recently developed highly sensitive cardiac troponin T (hs-cTnT) assay for providing prognostic information on patients with sepsis.	Hydrogen	101-103	troponin T2, cardiac type	Homo sapiens	104-108
21183353-4	2011	The most potent inhibitor, tert-alcohol containing (R)-12 (IC(50)=0.19muM) was co-crystallized in the active site of the BACE-1 protease, furnishing a novel binding mode in which the N-terminal amine makes a hydrogen bond to one of the catalytic aspartic acids.	Hydrogen	208-216	latexin	Homo sapiens	70-73
21183353-4	2011	The most potent inhibitor, tert-alcohol containing (R)-12 (IC(50)=0.19muM) was co-crystallized in the active site of the BACE-1 protease, furnishing a novel binding mode in which the N-terminal amine makes a hydrogen bond to one of the catalytic aspartic acids.	Hydrogen	208-216	beta-secretase 1	Homo sapiens	121-127
25346782-8	2011	In HER2, we also predict a role for phosphorylated Y877 in bridging a network of hydrogen bonds that fasten the A-loop in its active conformation, suggesting that HER2 may be unique among the ErbB members in requiring A-loop tyrosine phosphorylation for functionality.	Hydrogen	81-89	erb-b2 receptor tyrosine kinase 2	Homo sapiens	163-167
25346782-8	2011	In HER2, we also predict a role for phosphorylated Y877 in bridging a network of hydrogen bonds that fasten the A-loop in its active conformation, suggesting that HER2 may be unique among the ErbB members in requiring A-loop tyrosine phosphorylation for functionality.	Hydrogen	81-89	epidermal growth factor receptor	Homo sapiens	192-196
20852254-8	2010	Molecular modeling and molecular dynamics simulations reveal distinct hydrogen-bonding patterns in the active site of E. coli MUG that account for the specificity differences between E. coli MUG and human thymine DNA glycosylase as well as that between the wild type MUG and the Asn-140 and Ser-23 mutants.	Hydrogen	70-78	thymine DNA glycosylase	Homo sapiens	205-228
20593226-5	2011	The intermolecular interactions of CPC were much stronger than those of CPA, which promoted molecular association through intermolecular hydrogen bonding to form multimers.	Hydrogen	137-145	carboxypeptidase A1	Homo sapiens	72-75
20850545-10	2011	The inhibitor 1 beta-aldehyde group is shown to make a hydrogen bond with catalytic His163, whereas the ketone carbonyl oxygen of the inhibitor 2 interacts with the oxyanion hole.	Hydrogen	55-63	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	4-15
21278465-4	2011	In this paper hydrogen production using Ni-W-P cathode was studied for the first time in a single-chamber membrane-free MEC.	Hydrogen	14-22	C-C motif chemokine ligand 28	Homo sapiens	120-123
20031174-12	2011	In littermate mice, the peak expression levels of TNF-alpha and IL-6 in the liver was observed 1h after PH, which was consistent with data in previous reports.	Hydrogen	95-97	tumor necrosis factor	Mus musculus	50-59
20031174-12	2011	In littermate mice, the peak expression levels of TNF-alpha and IL-6 in the liver was observed 1h after PH, which was consistent with data in previous reports.	Hydrogen	95-97	interleukin 6	Mus musculus	64-68
20805243-5	2011	Nab3-RRM establishes a clear preference for the central cytidine of the UCUU motif, which forms pseudo-base pairing interactions primarily through hydrogen bonds to main chain atoms and one serine hydroxyl group.	Hydrogen	147-155	Nab3p	Saccharomyces cerevisiae S288C	0-4
22242116-7	2011	The nuclear gene disrupted in the high H2 producing mutant stm6glc4 encodes for the mitochondrial transcription termination factor (mTERF) MOC1, whose expression strongly increases during -S-induced H2 production in WT strains.	Hydrogen	39-41	uncharacterized protein	Chlamydomonas reinhardtii	84-130
22242116-7	2011	The nuclear gene disrupted in the high H2 producing mutant stm6glc4 encodes for the mitochondrial transcription termination factor (mTERF) MOC1, whose expression strongly increases during -S-induced H2 production in WT strains.	Hydrogen	39-41	uncharacterized protein	Chlamydomonas reinhardtii	139-143
22242116-7	2011	The nuclear gene disrupted in the high H2 producing mutant stm6glc4 encodes for the mitochondrial transcription termination factor (mTERF) MOC1, whose expression strongly increases during -S-induced H2 production in WT strains.	Hydrogen	199-201	uncharacterized protein	Chlamydomonas reinhardtii	84-130
22242116-7	2011	The nuclear gene disrupted in the high H2 producing mutant stm6glc4 encodes for the mitochondrial transcription termination factor (mTERF) MOC1, whose expression strongly increases during -S-induced H2 production in WT strains.	Hydrogen	199-201	uncharacterized protein	Chlamydomonas reinhardtii	139-143
22242116-9	2011	Furthermore knock-down of MOC1 in a WT strain was shown to improve the total H2 yield significantly suggesting that this strategy could be applied to further enhance H2 production in other strains already displaying a high H2 production capacity.	Hydrogen	77-79	uncharacterized protein	Chlamydomonas reinhardtii	26-30
22242116-9	2011	Furthermore knock-down of MOC1 in a WT strain was shown to improve the total H2 yield significantly suggesting that this strategy could be applied to further enhance H2 production in other strains already displaying a high H2 production capacity.	Hydrogen	166-168	uncharacterized protein	Chlamydomonas reinhardtii	26-30
22242116-9	2011	Furthermore knock-down of MOC1 in a WT strain was shown to improve the total H2 yield significantly suggesting that this strategy could be applied to further enhance H2 production in other strains already displaying a high H2 production capacity.	Hydrogen	166-168	uncharacterized protein	Chlamydomonas reinhardtii	26-30
20870009-10	2010	RBL-induced phosphorylation of ERK1/2 and p38 MAPK was detected at 1h and 3h respectively.	Hydrogen	67-69	mitogen-activated protein kinase 3	Homo sapiens	31-37
21094140-0	2010	1H NMR-based metabolomic study on resistance to diet-induced obesity in AHNAK knock-out mice.	Hydrogen	0-2	AHNAK nucleoprotein (desmoyokin)	Mus musculus	72-77
20888834-11	2010	The importance of hydrophobic interactions and hydrogen bonds in the stability of the Abeta fibril structure was examined by carrying out additional canonical MD simulations of oligomers with different numbers of chains (4-16 chains), with the fibril structure as the initial conformation.	Hydrogen	47-55	amyloid beta precursor protein	Homo sapiens	86-91
21108306-8	2010	Here various experimental conditions, as well as a quenched-flow apparatus, are utilized to monitor cytochrome c amide hydrogen exchange behaviors over more than eight orders of magnitude (0.0044-1 000 000 s), when converted into the standard exchange condition (pH 7 and 23 C).	Hydrogen	119-127	cytochrome c, somatic	Homo sapiens	100-112
20869434-1	2010	Drosophila mitochondria contain two peroxidases, peroxiredoxin 3 (dPrx3) and peroxiredoxin 5 (dPrx5), which together constitute the sole known intramitochondrial mechanism for the catalytic removal of hydrogen and organic peroxides.	Hydrogen	201-209	Peroxiredoxin 3	Drosophila melanogaster	49-64
20869434-1	2010	Drosophila mitochondria contain two peroxidases, peroxiredoxin 3 (dPrx3) and peroxiredoxin 5 (dPrx5), which together constitute the sole known intramitochondrial mechanism for the catalytic removal of hydrogen and organic peroxides.	Hydrogen	201-209	Peroxiredoxin 3	Drosophila melanogaster	66-71
20920557-3	2010	ISA potently inhibited protein translation, and induced a slow but prolonged activation of the stress-activated protein kinases, JNK and p38, at between 1h and 6h after treatment.	Hydrogen	153-155	mitogen-activated protein kinase 8	Homo sapiens	129-132
20920557-3	2010	ISA potently inhibited protein translation, and induced a slow but prolonged activation of the stress-activated protein kinases, JNK and p38, at between 1h and 6h after treatment.	Hydrogen	153-155	mitogen-activated protein kinase 14	Homo sapiens	137-140
21077628-4	2010	The average Ti-H2 interaction energies in molecules incorporating benzyl ancillary ligands (models of the experimental systems) increase as the number of bound H2 units increases from two to four, in agreement with the experimental observation that the H2 adsorption enthalpy increases as the number of adsorbed H2 molecules increases.	Hydrogen	160-162	RuvB like AAA ATPase 2	Homo sapiens	12-17
21077628-4	2010	The average Ti-H2 interaction energies in molecules incorporating benzyl ancillary ligands (models of the experimental systems) increase as the number of bound H2 units increases from two to four, in agreement with the experimental observation that the H2 adsorption enthalpy increases as the number of adsorbed H2 molecules increases.	Hydrogen	160-162	RuvB like AAA ATPase 2	Homo sapiens	12-17
20919747-8	2010	A putative binding model was proposed based on CoMFA and CoMSIA contour maps and docking simulations; formation of pi-stacking, water bridge and specific hydrogen bonding were deemed important interactions between ligands and PDE-5.	Hydrogen	154-162	phosphodiesterase 5A	Homo sapiens	226-231
20696493-7	2010	These findings will help to tailor PetF for achieving an optimized photobiotechnological hydrogen production in C. reinhardtii, which might also benefit from new insights into the mechanism of how oxygen attacks the active site metal cluster of HydA1.	Hydrogen	89-97	uncharacterized protein	Chlamydomonas reinhardtii	35-39
21042738-10	2010	To discover candidate eRNAs with multiple high affinity target sites or sequences (and thereafter targets), we searched for sequences containing more than randomly probable G and C. G and C bind with more hydrogen bonds than the pair A:T. We identified the sequence, Notch-1,33-56 in the ORF of Notch-1 mRNA.	Hydrogen	205-213	notch receptor 1	Homo sapiens	267-274
20973548-6	2010	The nAChR structural model, simulating the binding site interactions of the furan-2,5-dimethylene-tethered bis-IMI, reveals that the furan ring is nestled in a hydrophobic pocket, consisting of three aromatic amino acids, and is stabilized via hydrogen bonding.	Hydrogen	244-252	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	4-9
20816729-8	2010	Expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and chemokine (MIP-1alpha) in lung showed an increase from 1h to 24h after instillation and recovered thereafter.	Hydrogen	132-134	interleukin 1 beta	Mus musculus	42-50
20816729-8	2010	Expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and chemokine (MIP-1alpha) in lung showed an increase from 1h to 24h after instillation and recovered thereafter.	Hydrogen	132-134	interleukin 6	Mus musculus	52-56
20816729-8	2010	Expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and chemokine (MIP-1alpha) in lung showed an increase from 1h to 24h after instillation and recovered thereafter.	Hydrogen	132-134	tumor necrosis factor	Mus musculus	62-86
20839296-7	2010	For cytochrome c, cytochrome b(562) and triosephophate isomerase, independent folding units have been determined on the basis of hydrogen exchange experiments and misincorporation proton-alkyl exchange experiments.	Hydrogen	129-137	cytochrome c, somatic	Homo sapiens	4-16
20967906-3	2010	The solid-state structure of the Co(II)-Borromeate reveals that six MeOH molecules, arranged in a [O--H...O] hydrogen bonded, chair-like conformation, are located within its oxophilic central cavity.	Hydrogen	109-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-50
21030680-3	2010	In wild-type p110alpha, N345 in the C2 domain forms hydrogen bonds with D560 and N564 in the inter-SH2 (iSH2) domain of p85, and mutations of p110alpha or p85 that disrupt this interface lead to increased basal activity and transformation.	Hydrogen	52-60	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	13-22
21030680-3	2010	In wild-type p110alpha, N345 in the C2 domain forms hydrogen bonds with D560 and N564 in the inter-SH2 (iSH2) domain of p85, and mutations of p110alpha or p85 that disrupt this interface lead to increased basal activity and transformation.	Hydrogen	52-60	extracellular matrix protein 1	Mus musculus	120-123
21030680-3	2010	In wild-type p110alpha, N345 in the C2 domain forms hydrogen bonds with D560 and N564 in the inter-SH2 (iSH2) domain of p85, and mutations of p110alpha or p85 that disrupt this interface lead to increased basal activity and transformation.	Hydrogen	52-60	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	142-151
20939497-0	2010	Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange.	Hydrogen	89-97	rhodopsin	Homo sapiens	57-66
20939497-2	2010	Utilizing His residues found spaced throughout the GPCR, rhodopsin, we used His hydrogen-deuterium exchange (His-HDX) to monitor long-time scale structural rearrangements previously inaccessible by other means.	Hydrogen	80-88	rhodopsin	Homo sapiens	57-66
20821791-0	2010	High specificity in protein recognition by hydrogen-bond-surrogate alpha-helices: selective inhibition of the p53/MDM2 complex.	Hydrogen	43-51	tumor protein p53	Homo sapiens	110-113
20852764-1	2010	Uracil-terminated telechelic sulfonated polyimides (SPI-U) were transformed into noncovalent network membranes through biocomplementary hydrogen bonding recognition in the presence of an adenine-based crosslinking agent.	Hydrogen	136-144	chromogranin A	Homo sapiens	52-55
20831237-3	2010	The highly accurate CCSD(T)/complete basis set (CBS) value of the interaction energy for the model diborane   benzene complex in a stacking geometry exhibiting a B(2)H   pi hydrogen bond was calculated to be -4.0 kcal mol(-1).	Hydrogen	173-181	cystathionine beta-synthase	Homo sapiens	48-51
20863730-8	2010	The obtained model included hydrophobe, hydrogen bond acceptor and hydrogen bond donor features; it was able to identify the active AR inhibitors from the remaining compounds.	Hydrogen	40-48	aldo-keto reductase family 1 member B	Homo sapiens	132-134
20863730-8	2010	The obtained model included hydrophobe, hydrogen bond acceptor and hydrogen bond donor features; it was able to identify the active AR inhibitors from the remaining compounds.	Hydrogen	67-75	aldo-keto reductase family 1 member B	Homo sapiens	132-134
20844028-0	2010	Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein.	Hydrogen	141-149	major histocompatibility complex, class I, A	Homo sapiens	63-68
20844028-4	2010	Furthermore, the crystal structure of HLA-A*2402 complexed with peptide N1 was determined, and the featured peptide was characterized with two unexpected intrachain hydrogen bonds which augment the central residues to bulge out of the binding groove.	Hydrogen	165-173	major histocompatibility complex, class I, A	Homo sapiens	38-43
20845925-3	2010	Recrystallization from water/acetone leads to single crystals of H(2)tfBDC 2H(2)O (2, P2(1)/c, Z = 2), where an extensive hydrogen bonding network is found.	Hydrogen	122-130	cyclin dependent kinase inhibitor 1A	Homo sapiens	86-100
20563763-0	2010	1H, 15N and 13C assignments of an intramolecular Lmo2-LIM2/Ldb1-LID complex.	Hydrogen	0-2	lens intrinsic membrane protein 2	Homo sapiens	54-58
20800878-4	2010	OTC can interact with catalase to form a complex mainly by van der Waals" interactions and hydrogen bonds with one binding site.	Hydrogen	91-99	catalase	Homo sapiens	22-30
20947021-2	2010	Previously, we demonstrated that hydrogen/deuterium exchange (HDX) can be applied to determine novel mechanism of action of PPARgamma ligands and in predicting tissue specificity of selective estrogen receptor modulators.	Hydrogen	33-41	peroxisome proliferator activated receptor gamma	Homo sapiens	124-133
26616766-5	2010	The performance of this algorithm has been tested for the CH4/CD3H/CD4 + CF3 hydrogen abstraction reactions with encouraging results, i.e., when the fitting is performed using 13 points, the algorithm is about 30 times faster than the full calculation with deviations that are smaller than 5%.	Hydrogen	77-85	CD4 molecule	Homo sapiens	67-70
20623209-0	2010	1H, 15N and 13C chemical shift assignments of the Cdt1 binding domain of human Mcm6.	Hydrogen	0-2	minichromosome maintenance complex component 6	Homo sapiens	79-83
20503119-0	2010	1H, 15N, and 13C chemical shift assignments of calcium-binding protein 1 with Ca2+ bound at EF1, EF3 and EF4.	Hydrogen	0-2	calcium binding protein 1	Homo sapiens	47-72
20607461-0	2010	1H, 13C and 15N chemical shift assignments for the N-terminal domain of the voltage-gated potassium channel-hERG.	Hydrogen	0-2	ETS transcription factor ERG	Homo sapiens	108-112
20804197-3	2010	Molecular modeling studies showed that the methylsulfone group of these compounds was inserted deep in the pocket of the human COX-2 binding site, in an orientation that precludes hydrogen bonding with Arg120, Ser353, and Tyr355 through their oxygen atoms.	Hydrogen	180-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
20631153-8	2010	Molecular modeling of wild and mutant mouse Wdr36 revealed that deletion at positions 605-607 removed three residues and a hydrogen bond, required to stabilize anti-parallel beta-sheet of the 6th beta-propeller in the second domain.	Hydrogen	123-131	WD repeat domain 36	Mus musculus	44-49
21034038-1	2010	The control of the ratio of hydrogen to the deuterium is one of the very important issues for ion cyclotron range of frequency (ICRF) minority heating as well as the plasma wall interaction in the tokamak.	Hydrogen	28-36	regenerating family member 1 alpha	Homo sapiens	128-132
20621091-6	2010	Important differences were seen between intratracheal COMPOUND 1 and our previously published results with the oral PDE4 inhibitor roflumilast (Celly et al., 2005), as COMPOUND 1 rapidly (within 1h) reversed the decline in lung function when it was given therapeutically to rats already challenged with antigen.	Hydrogen	195-197	phosphodiesterase 4A	Homo sapiens	116-120
20734112-3	2010	In NMR studies of calmodulin, a 148 residue calcium binding protein, 19F and 1H-15N HSQC spectra reveal a significant extent of line broadening and the appearance of minor conformers in the presence of complete (&gt;95%) 3-fluorophenylalanine labeling.	Hydrogen	77-79	calmodulin 1	Homo sapiens	18-28
20660185-0	2010	Local conformational stability of HIV-1 gp120 in unliganded and CD4-bound states as defined by amide hydrogen/deuterium exchange.	Hydrogen	101-109	CD4 molecule	Homo sapiens	64-67
20660185-5	2010	On average, unliganded core gp120 displayed &gt;10,000-fold slower exchange of backbone-amide hydrogens than a theoretically unstructured protein of the same composition, with binding by CD4 reducing the rate of gp120 amide exchange a further 10-fold.	Hydrogen	94-103	CD4 molecule	Homo sapiens	187-190
21160910-1	2010	BACKGROUND: Sodium/hydrogen exchanger-1 (NHE-1) contributes to maintaining intracellular pH (pHi).	Hydrogen	19-27	solute carrier family 9 member A1	Homo sapiens	41-46
20806954-9	2010	The hydrogen bonds formed between the INH peptide, residues Tyr1, Tyr3, and Leu7 with the BACE1 residues Leu267, Cys269, Trp270, Asp311, and Asp 317 can strengthen the binding of the BACE1-INH complex.	Hydrogen	4-12	beta-1,3-glucuronyltransferase 1	Homo sapiens	76-80
20806954-9	2010	The hydrogen bonds formed between the INH peptide, residues Tyr1, Tyr3, and Leu7 with the BACE1 residues Leu267, Cys269, Trp270, Asp311, and Asp 317 can strengthen the binding of the BACE1-INH complex.	Hydrogen	4-12	beta-secretase 1	Homo sapiens	90-95
20806954-9	2010	The hydrogen bonds formed between the INH peptide, residues Tyr1, Tyr3, and Leu7 with the BACE1 residues Leu267, Cys269, Trp270, Asp311, and Asp 317 can strengthen the binding of the BACE1-INH complex.	Hydrogen	4-12	beta-secretase 1	Homo sapiens	183-188
20877636-3	2010	We previously outlined the mode of binding between the TKB domain and various substrate peptide motifs, including epidermal growth factor receptor (EGFR) and Sprouty2 (Spry2), and demonstrated that an intrapetidyl hydrogen bond forms between the (pY-1) arginine or (pY-2) asparagine and the phosphorylated tyrosine, which is crucial for binding.	Hydrogen	214-222	epidermal growth factor receptor	Homo sapiens	114-146
20877636-3	2010	We previously outlined the mode of binding between the TKB domain and various substrate peptide motifs, including epidermal growth factor receptor (EGFR) and Sprouty2 (Spry2), and demonstrated that an intrapetidyl hydrogen bond forms between the (pY-1) arginine or (pY-2) asparagine and the phosphorylated tyrosine, which is crucial for binding.	Hydrogen	214-222	epidermal growth factor receptor	Homo sapiens	148-152
20877636-3	2010	We previously outlined the mode of binding between the TKB domain and various substrate peptide motifs, including epidermal growth factor receptor (EGFR) and Sprouty2 (Spry2), and demonstrated that an intrapetidyl hydrogen bond forms between the (pY-1) arginine or (pY-2) asparagine and the phosphorylated tyrosine, which is crucial for binding.	Hydrogen	214-222	sprouty RTK signaling antagonist 2	Homo sapiens	158-166
20877636-3	2010	We previously outlined the mode of binding between the TKB domain and various substrate peptide motifs, including epidermal growth factor receptor (EGFR) and Sprouty2 (Spry2), and demonstrated that an intrapetidyl hydrogen bond forms between the (pY-1) arginine or (pY-2) asparagine and the phosphorylated tyrosine, which is crucial for binding.	Hydrogen	214-222	sprouty RTK signaling antagonist 2	Homo sapiens	168-173
20637191-3	2010	Our genetic and biochemical analyses show that Sulf1 acts as a novel regulator of the Wg morphogen gradient by modulating the sulfation status of HS on the cell surface in the developing wing.	Hydrogen	146-148	Sulfated	Drosophila melanogaster	47-52
20156428-6	2010	Hydrogen-bonding interactions between the fluoride leaving group of GB with Y124 in AChE are observed throughout the reaction profile.	Hydrogen	0-8	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-88
20715760-10	2010	Cyclic voltammetry was used to determine that the midpoint potentials of the two hemes in cytochrome c(4) are 240 and 340 mV (vs standard hydrogen electrode), similar to the electrochemical properties of other c(4)-type cytochromes.	Hydrogen	138-146	cytochrome c, somatic	Homo sapiens	90-102
21105391-3	2010	It was demonstrated from the FTIR spectra that the PEF treatment under 50 kV x cm(-1) had induced the increase in hydrogen bonds amidst in the intermolecule and intramolecule of SPI, and the increase in C--O--O bonds stretch vibration and the P==O or P--O--C stretch vibration, which is positive relative to the increase in the time of PEF treatment.	Hydrogen	114-122	chromogranin A	Homo sapiens	178-181
20620150-10	2010	Proper orientation of the substrate-binding residues for catalysis is likely to be maintained by an interprotomer hydrogen-bonding network of residues Asn196, Gln199, and Arg231, suggesting a network-based substrate recognition of GDH.	Hydrogen	114-122	lambda-crystallin	Oryctolagus cuniculus	231-234
20814093-2	2010	Furthermore, the carbonyl group acts as a double H-atom acceptor in the formation of a second, weaker, hydrogen bond of the type C-H...O=C [C...O = 3.283 (2) A] with the methyl group of the ester group of a second neighbouring molecule at (x, -y - 1/2, z - 1/2).	Hydrogen	103-111	RNA, Ro60-associated Y1	Homo sapiens	243-260
20814093-3	2010	The methyl group also acts as a weak hydrogen-bond donor, symmetry-related to the latter described C-H...O=C interaction, to a third molecule at (x, -y - 1/2, z + 1/2) to form a two-dimensional network.	Hydrogen	37-45	RNA, Ro60-associated Y1	Homo sapiens	149-166
20687526-10	2010	In aggregate, our results suggest that the hydrogen bonding of arginine to TAR RNA dictates the binding interaction.	Hydrogen	43-51	RNA binding motif protein 8A	Homo sapiens	75-78
20643473-5	2010	The ATR/FT-IR results revealed that under acidic conditions, hydrogen-bonded carboxyl groups were present in both zwitterionic EDDS and EDTA.	Hydrogen	61-69	ATR serine/threonine kinase	Homo sapiens	4-7
20661903-6	2010	The NBO method reveals that the LP(O) --&gt; sigma*(N-H) hyperconjugative interaction is weakened on going from the six-membered chelate ring to the seven-membered one due to a more bent hydrogen bond in the former case.	Hydrogen	187-195	lactoperoxidase	Homo sapiens	32-37
20615585-4	2010	Molecular docking studies revealed that the hydrogen bonding interaction between the benzoheterocyclic core and NMT might be essential in the orientation of the inhibitor to a proper position.	Hydrogen	44-52	N-myristoyltransferase 1	Homo sapiens	112-115
20669983-4	2010	When MCF-7 cells were treated with the analogues, those resulting from hydrogen substitution by isopropyl (3d), isobutyl (3f), cyclopentyl (3g), and pyrano- (2) inhibited cell proliferation, estrogen-induced transcriptional activity, and estrogen receptor (ER) regulated progesterone receptor (PgR) gene expression.	Hydrogen	71-79	estrogen receptor 1	Homo sapiens	238-255
20462186-1	2010	Kinetic acidities of arenes, ArH, measured some time ago by hydrogen isotope exchange kinetics with lithium cyclohexylamide (LiCHA) in cyclohexylamine (CHA) show a wide range of reactivities that involve several electronic mechanisms.	Hydrogen	60-68	low density lipoprotein receptor adaptor protein 1	Homo sapiens	29-32
20669983-4	2010	When MCF-7 cells were treated with the analogues, those resulting from hydrogen substitution by isopropyl (3d), isobutyl (3f), cyclopentyl (3g), and pyrano- (2) inhibited cell proliferation, estrogen-induced transcriptional activity, and estrogen receptor (ER) regulated progesterone receptor (PgR) gene expression.	Hydrogen	71-79	estrogen receptor 1	Homo sapiens	257-259
20537524-3	2010	Hydrogen gas was generated using bovine serum albumin (BSA, 700 mg/L) in a single-chamber MEC at a rate of Q=0.42+/-0.07 m(3)/m(3)/day and a yield of Y(H2) = 21.0 +/- 5.0 mmol-H2/g-COD, with an energy recovery (relative to electrical input) of eta(E)=75+/-12% (applied voltage of 0.6 V).	Hydrogen	0-8	C-C motif chemokine ligand 28	Homo sapiens	90-93
20808434-3	2010	To understand this, comprehensive analysis of hydrophobic interactions, hydrogen bonding and binding affinity have been analyzed at the interface of c-Src and c-Abl kinases and 4-amino substituted 1H-pyrazolo [3, 4-d] pyrimidine compounds.	Hydrogen	72-80	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	149-154
20669935-11	2010	Thus, triplex structures containing a 3"-overhang represent preferred substrates for DHX9, where it removes the strand with Hoogsteen hydrogen-bonded bases.	Hydrogen	134-142	DExH-box helicase 9	Homo sapiens	85-89
20434429-4	2010	Homologous bifunctional catalase-peroxidases (KatGs) are unique in having both a peroxidase and high hydrogen dismutation activity without inhibition reactions.	Hydrogen	101-109	catalase	Homo sapiens	24-32
20704392-8	2010	Computational modeling suggests that the AIE luminogens dock in the hydrophobic cleft between subdomains IIA and IIIA of HSA with the aid of hydrophobic effect, charge neutralization, and hydrogen bonding interactions, offering mechanistic insight into the microenvironment inside the hydrophobic cavity.	Hydrogen	188-196	albumin	Homo sapiens	121-124
20180658-9	2010	Fourier transform infrared spectroscopy analysis demonstrated the presence of intermolecular hydrogen bonding between PX and Eu S100 in SD.	Hydrogen	93-101	S100 calcium binding protein A1	Homo sapiens	128-132
20620068-5	2010	The most effective BACE 1 inhibitor 9f (27.85+/-2.46 micromol/L) was selected for further receptor-binding studies, the result of which indicated that an essential hydrogen bonds was formed between the urea group of 9f and the catalytic aspartate Asp228.	Hydrogen	164-172	beta-secretase 1	Homo sapiens	19-25
20466030-10	2010	The CP Ti/Vita Titankeramik (0.5h 5% (w/v), 1h 5% (w/v) and 0.5h 10% (w/v)) groups showed the highest G-value (36.94+/-3.25, 38.87+/-7.91 and 37.22+/-5.76J/m(2)) amongst their groups.	Hydrogen	44-46	carnitine palmitoyltransferase 1B	Homo sapiens	4-9
20960101-14	2010	Insulin analogs Glulisine and Lispro were proved to have equivalent pharmacokinetic and pharmacodynamic parameters when administered to healthy Chinese adults, but with Glulisine showing greater AUC(0-1h) after injection.	Hydrogen	201-203	insulin	Homo sapiens	0-7
20476793-7	2010	Hydrogen bond interactions, salt-bridge formations and pi-stacking were observed between the ligands and Phe731, Lys753, Asp863 and Asp808 of HER2 protein.	Hydrogen	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	142-146
20476796-10	2010	The analysis further revealed other hydrogen bond interactions, across crucial domains in Bax, which are mediated by water molecules across the length of simulation.	Hydrogen	36-44	BCL2 associated X, apoptosis regulator	Homo sapiens	90-93
20450932-4	2010	The four residues Arg476, Arg478, Val479 and Tyr583, all of which are involved in both ATP and GDP binding by hydrogen bonds, might play important roles in the stabilization of TG2 by ATP or GDP.	Hydrogen	110-118	transglutaminase 2	Homo sapiens	177-180
20713214-10	2010	RESULTS: The mRNA expression levels of Wnt11, PKCalpha, and CaMKII were significantly decreased at 1H in Cd group compared to controls (P &lt; .05).	Hydrogen	99-101	Wnt family member 11	Gallus gallus	39-44
20305288-3	2010	The intestinal infusion of TCA into the CBF rat rapidly (1h) activated the AKT (approximately 9-fold) and ERK1/2 (3- to 5-fold) signaling pathways, downregulated (approximately 50%, 30 min) the mRNA levels of PEPCK and G-6-Pase, and induced (14-fold in 3 h) SHP mRNA.	Hydrogen	57-59	AKT serine/threonine kinase 1	Rattus norvegicus	75-78
20545310-4	2010	Molecular dynamics (MD) simulations reveal that the high-affinity TIMP-1 mutants exhibit significantly reduced binding interface flexibility and more stable hydrogen bond networks.	Hydrogen	157-165	TIMP metallopeptidase inhibitor 1	Homo sapiens	66-72
20492513-10	2010	Additionally, hydrogen-rich saline markedly increased the activities of anti-oxidant enzymes superoxide dismutase and catalase and downregulated extracellular signal-regulated protein kinase (ERK)1/2 activation.	Hydrogen	14-22	catalase	Rattus norvegicus	118-126
20576629-4	2010	Novel V(H)/V(L) interface engineering in hVB22 (scFv)(2), in which hydrogen bonding between H39 and L38 was substituted with electrostatic interaction to enhance the desired V(H)/V(L) association and inhibit the undesired V(H)/V(L) association, enabled selective expression of the desired conformational isomer without any reduction in biological activity or thermal stability.	Hydrogen	67-75	immunglobulin heavy chain variable region	Homo sapiens	48-52
20576629-4	2010	Novel V(H)/V(L) interface engineering in hVB22 (scFv)(2), in which hydrogen bonding between H39 and L38 was substituted with electrostatic interaction to enhance the desired V(H)/V(L) association and inhibit the undesired V(H)/V(L) association, enabled selective expression of the desired conformational isomer without any reduction in biological activity or thermal stability.	Hydrogen	67-75	ribosomal protein L38	Homo sapiens	100-103
20576629-6	2010	Because the hydrogen bonding interaction between H39 and L38 and the surrounding residues are highly conserved in human antibody sequences, V(H)/V(L) interface engineering could be generally applied to various (scFv)(2) molecules for selective expression and inhibition of the isomerization of conformational isomers.	Hydrogen	12-20	ribosomal protein L38	Homo sapiens	57-60
20576629-6	2010	Because the hydrogen bonding interaction between H39 and L38 and the surrounding residues are highly conserved in human antibody sequences, V(H)/V(L) interface engineering could be generally applied to various (scFv)(2) molecules for selective expression and inhibition of the isomerization of conformational isomers.	Hydrogen	12-20	immunglobulin heavy chain variable region	Homo sapiens	211-215
20616056-5	2010	Here we use unnatural amino acid mutagenesis coupled with agonist analogs to examine whether such a hydrogen bond is functionally significant in the alpha4beta2 neuronal nAChR, the receptor most associated with nicotine addiction.	Hydrogen	100-108	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	170-175
20444690-3	2010	The key structural differences between this new structure and previously published structures are two new hydrogen bonds at positions Ile(37) and Glu(38) in strand C and Lys(66) in strand E, and a hydrophobic pocket around the center of the protein found in Ctid-beta2m.	Hydrogen	106-114	beta-2-microglobulin	Gallus gallus	263-269
20565102-13	2010	In particular, the presence of a polar negative group at a distance of 6-8 A from a hydrogen bond donor in a compound is predicted to be a quite structure-specific pharmacophore that increases hERG blockage.	Hydrogen	84-92	ETS transcription factor ERG	Homo sapiens	193-197
20575550-5	2010	Our data showed that the minimal elements crucial for high-affinity binding of MLL1 to WDR5 are -CO-ARA-NH- motif and two intramolecular hydrogen bonds that stabilize the conformation of this motif.	Hydrogen	137-145	WD repeat domain 5	Homo sapiens	87-91
20518555-5	2010	Using non-natural nucleotide analogues, we showed that hydrogen bonding interactions between residue R357 of human Rev1 and an incoming dNTP are not essential for DNA synthesis.	Hydrogen	55-63	REV1 DNA directed polymerase	Homo sapiens	115-119
20399772-5	2010	Western blot experiments demonstrated that phosphorylation of NF-kappaB p65 was time-dependently induced during organ culture starting at 1h.	Hydrogen	138-140	synaptotagmin 1	Rattus norvegicus	72-75
20471394-7	2010	The capability for multiple polar interactions, along with hydrogen bonding between TM segments, correlates with the observed highest affinity of the ErbB1/ErbB2 heterodimer, implying an important contribution of the TM helix-helix interaction to signal transduction.	Hydrogen	59-67	epidermal growth factor receptor	Homo sapiens	150-155
20471394-7	2010	The capability for multiple polar interactions, along with hydrogen bonding between TM segments, correlates with the observed highest affinity of the ErbB1/ErbB2 heterodimer, implying an important contribution of the TM helix-helix interaction to signal transduction.	Hydrogen	59-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	156-161
20655856-8	2010	MMP-3 also has enhanced subnanosecond fluctuations in helix A, in the beta-hairpin of strands IV and V, and before and including helix C. Hydrogen exchange protection in the EX2 regime suggests that MMP-3 possesses 2.8 kcal/mol higher folding stability than MMP-12(E219A).	Hydrogen	138-146	matrix metallopeptidase 3	Homo sapiens	0-5
20655856-8	2010	MMP-3 also has enhanced subnanosecond fluctuations in helix A, in the beta-hairpin of strands IV and V, and before and including helix C. Hydrogen exchange protection in the EX2 regime suggests that MMP-3 possesses 2.8 kcal/mol higher folding stability than MMP-12(E219A).	Hydrogen	138-146	matrix metallopeptidase 3	Homo sapiens	199-204
20527908-6	2010	An O-H group in the para position of ArO(*) or ArCH(2)(+) becomes more acidic than in the parent molecules and hence forms stronger HBs with hydrogen bond acceptors (HBAs) in the meta position.	Hydrogen	141-149	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	37-40
20524689-0	2010	Computational study on the interaction of N1 substituted pyrazole derivatives with B-raf kinase: an unusual water wire hydrogen-bond network and novel interactions at the entrance of the active site.	Hydrogen	119-127	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	83-88
20438866-6	2010	TLR4 protein expression and NF-kappaB DNA binding activity were significantly decreased in primary rat mammary epithelial cells pretreated with 1mumol/l retinoic acid at 1h post-LPS stimulation.	Hydrogen	170-172	toll-like receptor 4	Rattus norvegicus	0-4
20403340-10	2010	Treatment with curcumin either 1h before or immediately after LPS injection significantly ameliorated white matter injury and loss of preOLs, decreased activated microglia, and inhibited microglial expression of iNOS and translocation of p67phox and gp91phox to the microglial cell membranes in neonatal rat brains following LPS injection.	Hydrogen	31-33	nitric oxide synthase 2	Rattus norvegicus	212-216
20481518-0	2010	Density functional study of the thermodynamics of hydrogen production by tetrairon hexathiolate, Fe4[MeC(CH2S)3]2(CO)8, a hydrogenase model.	Hydrogen	50-58	C-C motif chemokine ligand 28	Homo sapiens	101-104
20189984-0	2010	SOD1 mutations targeting surface hydrogen bonds promote amyotrophic lateral sclerosis without reducing apo-state stability.	Hydrogen	33-41	superoxide dismutase 1	Homo sapiens	0-4
20481518-1	2010	The tetranuclear iron complex Fe(4)[MeC(CH(2)S)(3)](2)(CO)(8) (1) functions like a hydrogenase to catalyze proton reduction to H(2) in the presence of 2,6-dimethylpyridinium acid (LutH(+)).	Hydrogen	41-45	C-C motif chemokine ligand 28	Homo sapiens	36-39
20481637-0	2010	NH NMR shifts of new structurally characterized fac-[Re(CO)3(polyamine)]n+ complexes probed via outer-sphere hydrogen-bonding interactions to anions, including the paramagnetic [Re(IV)Br6]2- anion.	Hydrogen	109-117	FA complementation group C	Homo sapiens	48-51
20211631-1	2010	Models of growth hormone (GH) rhythmogenesis which we and others have presented suggest that the GH pulses in the circulation are generated by a GH-releasing hormone (GHRH) oscillator with a 1h periodicity.	Hydrogen	191-193	growth hormone 1	Homo sapiens	10-24
20347855-5	2010	The 5-HT transporter was evaluated by means of the specific binding of (3)H-paroxetine ((3)H-Par) to platelet membranes, as well as by means of (3)H-5-HT reuptake in whole platelets, at baseline (T0) and 1h after the stimulation (T1).	Hydrogen	204-206	solute carrier family 6 member 4	Homo sapiens	4-20
20207026-1	2010	Seawater acclimation in killifish, Fundulus heteroclitus, is mediated in part by a rapid (1h) translocation of CFTR Cl(-) channels from an intracellular pool to the plasma membrane in gill and increased CFTR-mediated Cl(-) secretion.	Hydrogen	90-92	cystic fibrosis transmembrane conductance regulator	Fundulus heteroclitus	111-115
20211631-1	2010	Models of growth hormone (GH) rhythmogenesis which we and others have presented suggest that the GH pulses in the circulation are generated by a GH-releasing hormone (GHRH) oscillator with a 1h periodicity.	Hydrogen	191-193	growth hormone 1	Homo sapiens	26-28
20211631-1	2010	Models of growth hormone (GH) rhythmogenesis which we and others have presented suggest that the GH pulses in the circulation are generated by a GH-releasing hormone (GHRH) oscillator with a 1h periodicity.	Hydrogen	191-193	growth hormone 1	Homo sapiens	97-99
20211631-1	2010	Models of growth hormone (GH) rhythmogenesis which we and others have presented suggest that the GH pulses in the circulation are generated by a GH-releasing hormone (GHRH) oscillator with a 1h periodicity.	Hydrogen	191-193	growth hormone releasing hormone	Homo sapiens	145-165
20211631-1	2010	Models of growth hormone (GH) rhythmogenesis which we and others have presented suggest that the GH pulses in the circulation are generated by a GH-releasing hormone (GHRH) oscillator with a 1h periodicity.	Hydrogen	191-193	growth hormone releasing hormone	Homo sapiens	167-171
20303167-6	2010	This is a very significant improvement compared to the previously published results for CDC (90% TNF-alpha removal after 1h) and activated carbons.	Hydrogen	121-123	tumor necrosis factor	Homo sapiens	97-106
20620318-11	2010	Immunoreactivity of Msx1 and Msx2 at 1H was remarkably decreased in Cd group compared with controls.	Hydrogen	37-39	msh homeobox 2	Gallus gallus	29-33
20346696-4	2010	The order of hydrogen-donating ability was 1,5-DAN &gt; 5-ASA &gt; 2,5-DHB &gt; SA = CHCA.	Hydrogen	13-21	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
20432415-6	2010	A single-crystal X-ray diffraction analysis revealed that in the solid state the complex L.TNT consists of a supramolecular crystalline polymeric structure, the formation of which appears to be driven by intermolecular pi-pi interactions between two pyrene units and a TNT molecule held at a distance of 3.2-3.6 A, as well as by intra- and intermolecular hydrogen-bonds among the amide linkages.	Hydrogen	355-363	chromosome 16 open reading frame 82	Homo sapiens	91-94
20235230-4	2010	Remaining unresolved aspects of the reaction mechanism of TIM such as the protonation state of the first reaction intermediate and the properties of the hydrogen-bonding interactions in the active site are being addressed.	Hydrogen	153-161	triosephosphate isomerase 1	Homo sapiens	58-61
20351101-5	2010	CFTR binds to beta-strands C and D of FlnA-Ig21 using backbone-backbone hydrogen bonds, a linchpin serine residue, and hydrophobic side-chain packing.	Hydrogen	72-80	CF transmembrane conductance regulator	Homo sapiens	0-4
20351101-5	2010	CFTR binds to beta-strands C and D of FlnA-Ig21 using backbone-backbone hydrogen bonds, a linchpin serine residue, and hydrophobic side-chain packing.	Hydrogen	72-80	filamin A	Homo sapiens	38-42
20143816-12	2010	Models without frustration describe the sequence of folding events for cytochrome c well (as inferred from hydrogen-exchange experiments), thereby justifying their use as a starting point.	Hydrogen	107-115	cytochrome c, somatic	Homo sapiens	71-83
20499965-5	2010	These results should guide the spectroscopic search of the H(3) (-) ion in cold gases (below 100K) of molecular hydrogen in the presence of H(-) ions.	Hydrogen	112-120	H3 clustered histone 14	Homo sapiens	59-63
20405902-5	2010	Also observed as minor constituents are the next two lowest-energy structures, one in which the carboxylic acid (O-)H group hydrogen-bonds to the amino NH(2) group (G-2), and the other where intramolecular hydrogen bonding occurs between the NH(2) and the carboxylic acid O(-H) groups (G-3).	Hydrogen	124-132	crystallin gamma E, pseudogene	Homo sapiens	165-168
20394370-12	2010	The porosity of DUT-7 and DUT-7(rac) was proven by nitrogen and hydrogen physisorption measurements.	Hydrogen	64-72	AKT serine/threonine kinase 1	Homo sapiens	26-36
20422090-7	2010	In the structures of some of these derivatives the presence of secondary interactions such as weak hydrogen bonds of the type C-HO, C-HN or C-HX (X = F, Cl) or even MO interactions leads to supramolecular networks.	Hydrogen	99-107	nuclear receptor subfamily 4 group A member 3	Homo sapiens	132-136
19485922-6	2010	We recently found that CGRP stimulates VGCR by 350 % in as short as 1h.	Hydrogen	68-70	calcitonin related polypeptide alpha	Homo sapiens	23-27
20225050-5	2010	Because the excellent separation and retention order with Sil-CEA was maintained even in a normal-phase mobile phase such as a hexane-2-propanol, it is estimated that the CEA phase has multiple interaction mechanisms through stronger interactions such as dipole-dipole, carbonyl-pi, and hydrogen bonding interactions than the hydrophobic effect expected with ODS.	Hydrogen	287-295	CEA cell adhesion molecule 3	Homo sapiens	171-174
20439171-8	2010	Hydrogen bonding was the characteristic interaction between HO-PBDE molecules and TRbeta, and aromaticity had a negative effect on the thyroid hormone activity of HO-PBDEs.	Hydrogen	0-8	T cell receptor beta locus	Homo sapiens	82-88
20403587-2	2010	The results show that the carcinogenic mutation R249S affects the flexibility of L3 loop region in p53, inducing the loss of important hydrogen bonds observed at interaction in the wild-type with DNA, on the other hand the suppressor mutation H168R on the R249S assists in maintaining the wild-type like flexibility of the L3 region in p53 and thus recover the interaction terms lost in the carcinogenic mutation alone.	Hydrogen	135-143	tumor protein p53	Homo sapiens	99-102
20439171-10	2010	CONCLUSIONS: Hydrogen bonding and electrostatic interactions between HO-PBDEs and TRbeta are important factors governing thyroid hormone activities.	Hydrogen	13-21	T cell receptor beta locus	Homo sapiens	82-88
20623858-4	2010	The results showed that MC-RR degradation by attacking of ozone and hydrogen radicals mainly involved in substitution and cleavage of the Adda conjugated diene structure, cleavage of the peptide bond between Mdha and Ala. And Adda degradation pathway exerted a dominant position during the process.	Hydrogen	68-76	adducin 1	Homo sapiens	138-142
20188141-9	2010	Comparison to the erythropoietin receptor suggests that F104 engages in hydrogen-bonding interactions that are critical for binding to thrombopoietin.	Hydrogen	72-80	erythropoietin	Homo sapiens	18-32
20188141-9	2010	Comparison to the erythropoietin receptor suggests that F104 engages in hydrogen-bonding interactions that are critical for binding to thrombopoietin.	Hydrogen	72-80	thrombopoietin	Homo sapiens	135-149
20623858-4	2010	The results showed that MC-RR degradation by attacking of ozone and hydrogen radicals mainly involved in substitution and cleavage of the Adda conjugated diene structure, cleavage of the peptide bond between Mdha and Ala. And Adda degradation pathway exerted a dominant position during the process.	Hydrogen	68-76	adducin 1	Homo sapiens	226-230
20178340-4	2010	5 s) and photoinduced valence tautomerism result in trapping of the metastable Co(II)-state at low temperatures through intermolecular hydrogen bonding.	Hydrogen	135-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
20171955-7	2010	After Abeta1-42 injection, the levels of MDA, IL-6, and TNF-alpha were increased in brain tissues and hydrogen-rich saline treatment suppressed MDA, IL-6, and TNF-alpha concentration.	Hydrogen	102-110	interleukin 6	Rattus norvegicus	149-153
20171955-7	2010	After Abeta1-42 injection, the levels of MDA, IL-6, and TNF-alpha were increased in brain tissues and hydrogen-rich saline treatment suppressed MDA, IL-6, and TNF-alpha concentration.	Hydrogen	102-110	tumor necrosis factor	Rattus norvegicus	159-168
20333341-4	2010	Magnetic studies on Ni(ii) and Co(ii) compounds reveal that the triple hydrogen bonding bridge transmits ferromagnetic coupling, with J = 3.46 cm(-1) for the Ni(ii) compound and J = 1.12 cm(-1) for the Co(ii) compound.	Hydrogen	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-25
20333341-4	2010	Magnetic studies on Ni(ii) and Co(ii) compounds reveal that the triple hydrogen bonding bridge transmits ferromagnetic coupling, with J = 3.46 cm(-1) for the Ni(ii) compound and J = 1.12 cm(-1) for the Co(ii) compound.	Hydrogen	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
20333341-4	2010	Magnetic studies on Ni(ii) and Co(ii) compounds reveal that the triple hydrogen bonding bridge transmits ferromagnetic coupling, with J = 3.46 cm(-1) for the Ni(ii) compound and J = 1.12 cm(-1) for the Co(ii) compound.	Hydrogen	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-36
20333341-4	2010	Magnetic studies on Ni(ii) and Co(ii) compounds reveal that the triple hydrogen bonding bridge transmits ferromagnetic coupling, with J = 3.46 cm(-1) for the Ni(ii) compound and J = 1.12 cm(-1) for the Co(ii) compound.	Hydrogen	71-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-208
20156458-4	2010	The present study shows, by use of crystal structure analysis and isothermal titration calorimetry for a congeneric series of thrombin inhibitors, that extensive cooperative effects between hydrophobic contacts and hydrogen bond formation are intimately coupled via dynamic properties of the formed complexes.	Hydrogen	215-223	coagulation factor II, thrombin	Homo sapiens	126-134
20156458-5	2010	The formation of optimal lipophilic contacts with the surface of the thrombin S3 pocket and the full desolvation of this pocket can conflict with the formation of an optimal hydrogen bond between ligand and protein.	Hydrogen	174-182	coagulation factor II, thrombin	Homo sapiens	69-77
20222664-6	2010	We find that refinement with RDCs causes significant structural corrections and yields an ensemble that is in complete agreement with the measured RDCs and presents transient mid-range inter-residue interactions between strands beta1 and beta2 of the native protein, also observed in other studies based on trans-hydrogen bond (3)J(NC") scalar couplings and paramagnetic relaxation enhancements.	Hydrogen	313-321	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	228-233
19523879-5	2010	The cathodic hydrogen recovery was 17% for MEC 1 and 21% for MEC 2.	Hydrogen	13-21	ATR serine/threonine kinase	Homo sapiens	43-48
20354313-4	2010	The structure of (2SR,4RS)-8-chloro-9-methyl-2-exo-(prop-1-en-2-yl)-2,3,4,5-tetrahydro-1H-1,4-epoxy-1-benzazepine, C(14)H(16)ClNO, (V), contains a C-H...O hydrogen bond which links pairs of molecules into centrosymmetric R(2)(2)(6) dimers.	Hydrogen	155-163	PROP paired-like homeobox 1	Homo sapiens	52-58
20354313-5	2010	(2SR,4RS)-7,9-Dichloro-2-exo-(prop-1-en-2-yl)-2,3,4,5-tetrahydro-1H-1,4-epoxy-1-benzazepine, C(13)H(13)Cl(2)NO, (VI), is an inversion twin containing both the (2S,4R) and (2R,4S) enantiomers in the space group P2(1), and a C-H...O hydrogen bond links molecules of a given configuration into simple C(3) chains.	Hydrogen	231-239	PROP paired-like homeobox 1	Homo sapiens	30-36
20361867-6	2010	Within the heme pocket the dioxygen molecule is stabilized by a hydrogen bonded network including TyrB10 and GlnE7.GLB-1 exhibits high ligand affinity, which is, however, lower than in other globins with the same distal TyrB10-GlnE7 amino-acid pair.	Hydrogen	64-72	Globin-like protein	Caenorhabditis elegans	115-120
19523879-5	2010	The cathodic hydrogen recovery was 17% for MEC 1 and 21% for MEC 2.	Hydrogen	13-21	C-C motif chemokine ligand 28	Homo sapiens	43-46
19885922-2	2010	For both pSer-Pro and pThr-Pro peptides in the gas phase and in chloroform, the most preferred conformation has the alpha-helical structure for the pSer/pThr residue, the down-puckered polyproline I structure for the Pro residue, and the cis prolyl peptide bond between the two residues, in which two hydrogen bonds between the phosphate oxygens with the backbone N--H groups seem to play a role.	Hydrogen	301-309	parathyroid hormone 1 receptor	Homo sapiens	22-26
20013162-0	2010	1H, 13C and 15N resonance assignments of the Calmodulin-Munc13-1 peptide complex.	Hydrogen	0-2	calmodulin 1	Homo sapiens	45-55
20174897-0	2010	1H, 13C and 15N resonance assignments of a highly-soluble murine interleukin-3 analogue with wild-type bioactivity.	Hydrogen	0-2	interleukin 3	Mus musculus	65-78
20188552-4	2010	An X-ray co-crystal structure of one inhibitor with the mTOR-related PI3Kgamma revealed the key hydrogen bonding interactions.	Hydrogen	96-104	mechanistic target of rapamycin kinase	Homo sapiens	56-60
19885922-2	2010	For both pSer-Pro and pThr-Pro peptides in the gas phase and in chloroform, the most preferred conformation has the alpha-helical structure for the pSer/pThr residue, the down-puckered polyproline I structure for the Pro residue, and the cis prolyl peptide bond between the two residues, in which two hydrogen bonds between the phosphate oxygens with the backbone N--H groups seem to play a role.	Hydrogen	301-309	parathyroid hormone 1 receptor	Homo sapiens	153-157
20118243-8	2010	Hydrogen-deuterium exchange mass spectrometry mapped distinct sites of GBP that interact with LPS and with CRP, consistent with in silico predictions.	Hydrogen	0-8	C-reactive protein	Homo sapiens	107-110
20387553-3	2010	We have also demonstrated that endothelial nitric oxide synthase (eNOS) is a major source of EDHF/H2(0)2, where Cu, Zn-SOD is involved.	Hydrogen	98-100	nitric oxide synthase 3	Homo sapiens	31-64
20095048-0	2010	Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry.	Hydrogen	73-81	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	41-44
20175511-0	2010	Auxiliary-assisted palladium-catalyzed arylation and alkylation of sp2 and sp3 carbon-hydrogen bonds.	Hydrogen	86-94	Sp3 transcription factor	Homo sapiens	75-78
20152400-7	2010	The present method offers a time-saving way to simultaneous determination of angiotensin II and angiotensin-(1-7), since it can be completed in 10 min, compared to other methodologies reported in the literature for capillary electrophoresis and liquid chromatography, which require more than 1h for analysis of complex matrices, such as plasma and urine.	Hydrogen	292-294	angiotensinogen	Rattus norvegicus	77-91
21179345-2	2010	Having studied five QSAR models predicting the biological activities of 18 antidepressants, already approved for clinical treatment, in interaction with the serotonin transporter (SERT), we attempted to establish the membrane ionsa contributions (sodium, potassium, chlorine and calcium) supplied by donor/acceptor hydrogen bond character and electrostatic field to the antidepressant activity.	Hydrogen	315-323	solute carrier family 6 member 4	Homo sapiens	180-184
20148533-0	2010	Enhancement of hydrophobic interactions and hydrogen bond strength by cooperativity: synthesis, modeling, and molecular dynamics simulations of a congeneric series of thrombin inhibitors.	Hydrogen	44-52	coagulation factor II, thrombin	Homo sapiens	167-175
27462766-8	2010	Furthermore, from the interpretation of the best performing model it could be concluded that in comparison to nonsubstrates ABCB1 substrates generally show a higher number of hydrogen-bond acceptors, are more flexible and exhibit higher logP values.	Hydrogen	175-183	ATP binding cassette subfamily B member 1	Homo sapiens	124-129
20151706-3	2010	The primary process is the entropy-driven disintegration of the PPO hydration envelope based on cooperation of hydrophobic hydration and hydrogen bonding.	Hydrogen	137-145	protoporphyrinogen oxidase	Homo sapiens	64-67
20148533-3	2010	Herein we present data obtained from two separate series of thrombin inhibitors containing hydrophobic side chains of increasing size that bind in the S3 pocket and with, or without, an adjacent amine that engages in a hydrogen bond with Gly 216.	Hydrogen	219-227	coagulation factor II, thrombin	Homo sapiens	60-68
20821492-6	2010	Hydrogen bonding of the compound with Glu353 in the hERalpha is an important determinant of the estrogenic activity of para-HO-PBDEs and brominated bisphenol A.	Hydrogen	0-8	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	52-60
19961829-2	2010	Using molecular dynamics simulations of AQP0 and AQP1, we find that there is a sudden decrease in the distribution profile of water density along the pore of AQP0 in the region of residue Tyr23, which significantly disrupts the single file water chain by forming hydrogen bond with permeating water molecules.	Hydrogen	263-271	major intrinsic protein of lens fiber	Homo sapiens	40-44
19961829-2	2010	Using molecular dynamics simulations of AQP0 and AQP1, we find that there is a sudden decrease in the distribution profile of water density along the pore of AQP0 in the region of residue Tyr23, which significantly disrupts the single file water chain by forming hydrogen bond with permeating water molecules.	Hydrogen	263-271	aquaporin 1 (Colton blood group)	Homo sapiens	49-53
19961829-2	2010	Using molecular dynamics simulations of AQP0 and AQP1, we find that there is a sudden decrease in the distribution profile of water density along the pore of AQP0 in the region of residue Tyr23, which significantly disrupts the single file water chain by forming hydrogen bond with permeating water molecules.	Hydrogen	263-271	major intrinsic protein of lens fiber	Homo sapiens	158-162
20026130-0	2010	Intermonomer hydrogen bonds enhance GxxxG-driven dimerization of the BNIP3 transmembrane domain: roles for sequence context in helix-helix association in membranes.	Hydrogen	13-21	BCL2 interacting protein 3	Homo sapiens	69-74
20179344-7	2010	A hydrogen-bond network and changes in coiled-coil monomer interaction suggest that the HIP1 coiled-coil domain is uniquely suited to allow conformational flexibility.	Hydrogen	2-10	huntingtin interacting protein 1	Homo sapiens	88-92
19766506-16	2010	CONCLUSION: These results suggest some beneficial neuroprotective effects of erythropoietin in this model of global brain ischaemia induced by 1h of hypothermic circulatory arrest.	Hydrogen	143-145	erythropoietin	Homo sapiens	77-91
20018812-7	2010	Docking data indicated that these tetracyclic triterpenoids form hydrogen bonds within the phosphatidylinositol binding pocket of the Akt pleckstrin homology domain.	Hydrogen	65-73	AKT serine/threonine kinase 1	Homo sapiens	134-137
19856322-6	2010	Mechanistically, this is a cooperative process: key residues, particularly Lys120 and Arg280 acted as sensors; upon finding their hydrogen-bonding partners, they lock in, anchoring p53 into the major groove.	Hydrogen	130-138	tumor protein p53	Homo sapiens	181-184
20079794-7	2010	In group 2 and group 3, metallothionein I was administrated once at two different doses (1 or 2.5mg/kg i.p., respectively) 1h before TI intoxication.	Hydrogen	123-125	metallothionein 1	Rattus norvegicus	24-41
19808095-7	2010	Hydrogen bond-forming interactions and tight packing hydrophobic side chains that complement the puckering of the steroid backbone provide the molecular basis for the exclusive androgenic specificity of aromatase.	Hydrogen	0-8	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	203-212
19931613-12	2010	A ligand-based pharmacophore model for selective aromatase modulation (SAM) by the novel sulfonanilides identified an aromatic ring, two hydrogen bond acceptors, and a hydrophobic function as four key chemical features.	Hydrogen	137-145	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	49-58
20007698-0	2010	A network of hydrogen bonds on the surface of TLR2 controls ligand positioning and cell signaling.	Hydrogen	13-21	toll like receptor 2	Homo sapiens	46-50
19944699-0	2010	Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.	Hydrogen	81-89	CF transmembrane conductance regulator	Homo sapiens	36-40
20045315-1	2010	Through conformational restriction of a benzamide by formation of a seven-membered hydrogen-bond with an oxindole carbonyl group, a series of PARP inhibitors was designed for appropriate orientation for binding to the PARP surface.	Hydrogen	83-91	poly(ADP-ribose) polymerase 1	Homo sapiens	142-146
20045315-1	2010	Through conformational restriction of a benzamide by formation of a seven-membered hydrogen-bond with an oxindole carbonyl group, a series of PARP inhibitors was designed for appropriate orientation for binding to the PARP surface.	Hydrogen	83-91	poly(ADP-ribose) polymerase 1	Homo sapiens	218-222
20045315-7	2010	An additional hydrogen bond interaction of the piperidine nitrogen to Gly-888 also contributes to the binding affinity of 1e to PARP-1.	Hydrogen	14-22	poly(ADP-ribose) polymerase 1	Homo sapiens	128-134
19858003-3	2010	In the present study 1h treatment with 25muM etoposide was highly toxic and initiated a double-stranded DNA damage response as reflected by the recruitment of ATM, MDC1 and DNA-PKcs to gammaH2AX foci.	Hydrogen	21-23	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	173-181
19836212-5	2010	The obtained data suggested that LSZ embedment within the H(II) mesophase improved its thermal stability by hampering its helical structure destruction, apparently due to hydrogen bonding of the protein with monoolein polar heads.	Hydrogen	171-179	lysozyme	Homo sapiens	33-36
20030379-3	2010	Tracking all significant electron sinks (residual acetate, H(2), CH(4), biomass, and soluble microbial products (SMP)) in the single-chamber MEC showed that H(2) reoxidation by anode-respiring bacteria recycled H(2) between the cathode and the anode, and this caused the large discrepancy in H(2) production and harvest rates.	Hydrogen	157-161	C-C motif chemokine ligand 28	Homo sapiens	141-144
20030379-3	2010	Tracking all significant electron sinks (residual acetate, H(2), CH(4), biomass, and soluble microbial products (SMP)) in the single-chamber MEC showed that H(2) reoxidation by anode-respiring bacteria recycled H(2) between the cathode and the anode, and this caused the large discrepancy in H(2) production and harvest rates.	Hydrogen	157-161	C-C motif chemokine ligand 28	Homo sapiens	141-144
20030379-3	2010	Tracking all significant electron sinks (residual acetate, H(2), CH(4), biomass, and soluble microbial products (SMP)) in the single-chamber MEC showed that H(2) reoxidation by anode-respiring bacteria recycled H(2) between the cathode and the anode, and this caused the large discrepancy in H(2) production and harvest rates.	Hydrogen	157-161	C-C motif chemokine ligand 28	Homo sapiens	141-144
20030379-8	2010	Because of methane formation and biomass/SMP accumulation, the overall H(2) recovery was moderate at 1.8-2.0 mol of H(2)/mol of acetate in the MEC.	Hydrogen	71-75	C-C motif chemokine ligand 28	Homo sapiens	143-146
20030379-8	2010	Because of methane formation and biomass/SMP accumulation, the overall H(2) recovery was moderate at 1.8-2.0 mol of H(2)/mol of acetate in the MEC.	Hydrogen	116-120	C-C motif chemokine ligand 28	Homo sapiens	143-146
19916574-8	2010	The backbone hydrogen bonds in HBD-1 and HNP-3 are broken during MDS.	Hydrogen	13-21	defensin beta 1	Homo sapiens	31-36
19916575-3	2010	Simulations show that Pis1 and Pis-AA form the most hydrogen bonds and Pis-PG forms the fewest hydrogen bonds with lipid.	Hydrogen	52-60	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	22-26
20025219-3	2010	This last structural change is associated with a dramatic lowering of metallization pressure, so that BaReH(9) can be expected to turn metallic at the onset of the H(2)-containing phase (51 GPa).	Hydrogen	164-168	glycophorin A (MNS blood group)	Homo sapiens	190-193
19920147-3	2010	In this study, we identified the molecular basis for the unusual Hsp70/Hsp40 pairing using amide hydrogen exchange (HX) coupled with mass spectrometry and mutational analysis.	Hydrogen	97-105	type I HSP40 co-chaperone YDJ1	Saccharomyces cerevisiae S288C	71-76
20043639-3	2010	Two pathways for H(2) production are analyzed: one is a heterolytic route involving protonation of the hydride to release H(2) and generate Co(III); the other is a homoytic pathway requiring association of two Co(III)-hydrides.	Hydrogen	17-21	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	140-147
20043639-3	2010	Two pathways for H(2) production are analyzed: one is a heterolytic route involving protonation of the hydride to release H(2) and generate Co(III); the other is a homoytic pathway requiring association of two Co(III)-hydrides.	Hydrogen	17-21	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	210-217
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-167	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	127-130
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-167	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	138-141
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-167	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	138-141
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-167	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	138-141
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-167	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	124-131
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-166	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	127-130
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-166	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	138-141
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-166	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	138-141
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-166	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	138-141
20043639-5	2010	Examination of both the barriers and driving forces associated with the two pathways indicates that the homolytic reaction (Co(III)H + Co(III)H --&gt; 2 Co(II) + H(2)) is favored over the route that goes through a Co(III) intermediate (Co(III)H + H(+) --&gt; Co(III) + H(2)).	Hydrogen	162-166	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	124-131
20205869-10	2010	CONCLUSIONS: This study predicts that crucial hydrogen bonding between N-sh2 domain of Shp-1 and Kit activation loop can modulate the negative regulation of c-Kit kinase by Shp-1.	Hydrogen	46-54	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	157-162
20028185-10	2010	The in silico pharmacophore model of oxime affinity for binding to GA-inhibited AChE was found to require a hydrogen bond acceptor, a hydrogen bond donor at the two terminal regions, and an aromatic ring in the central region of the oximes.	Hydrogen	108-116	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
20017469-1	2010	During DNA repair, uracil DNA glycosylase (UDG) pulls unwanted uracil into its active site through hydrogen bonding and pi-pi stacking interactions.	Hydrogen	99-107	uracil DNA glycosylase	Homo sapiens	19-41
20017469-1	2010	During DNA repair, uracil DNA glycosylase (UDG) pulls unwanted uracil into its active site through hydrogen bonding and pi-pi stacking interactions.	Hydrogen	99-107	uracil DNA glycosylase	Homo sapiens	43-46
20017469-4	2010	Compound 1a contains a 2,6-bis(glycylamino)pyridine group, which mimics the amino acid residues of UDG that interact with uracil through a hydrogen-bonding network; it also possesses a pyrene moiety as a pi-pi stacking interaction element and fluorescent probe that mimics the aromatic groups (phenyl and fluorescent indolyl units) found in the active site of UDG.	Hydrogen	139-147	uracil DNA glycosylase	Homo sapiens	99-102
19931544-11	2010	In contrast, the level of Bcl-2 protein decreased 1h after GI-R and was restored to normal levels by intravenous administration of 17beta-estradiol.	Hydrogen	50-52	BCL2, apoptosis regulator	Rattus norvegicus	26-31
19962958-7	2010	This was due to apoptosis, since its action was blocked by the pan-caspase inhibitor zVADfmk (5 x 10(-5) mol/l) and TRAIL increased caspase-3 activity 1h after application.	Hydrogen	151-153	TNF superfamily member 10	Homo sapiens	116-121
20028185-10	2010	The in silico pharmacophore model of oxime affinity for binding to GA-inhibited AChE was found to require a hydrogen bond acceptor, a hydrogen bond donor at the two terminal regions, and an aromatic ring in the central region of the oximes.	Hydrogen	134-142	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
19748240-4	2010	The vibration FTIR analysis revealed that LSZ interacted with OH groups of glycerol monooleate (GMO) in the outer interface region, resulting in strong hydrogen bonding between the surfactant and its environment.	Hydrogen	152-160	lysozyme	Homo sapiens	42-45
19506924-5	2010	In particular the replacement of serine 256 and isoleucine 359 in LeuT(Aa) with glycine and threonine in hGAT-1 seems to facilitate the selection of GABA as the main substrate by changing the hydrogen bonding pattern in the active site to the amino group of the substrate.	Hydrogen	192-200	solute carrier family 6 member 1	Homo sapiens	105-111
22933858-1	2010	We build on our earlier quantum wavepacket study of hydrogen transfer in the biological enzyme, soybean lipoxygenase-1, by using von Neumann quantum measurement theory to gain qualitative insights into the transfer event.	Hydrogen	52-60	seed linoleate 13S-lipoxygenase-1	Glycine max	104-118
19889460-8	2010	MIP-2 and KC production in the LPS-treated air pouches correlated with an early neutrophil migration (1h after LPS injection), and both of these effects were significantly reduced in mice administered with PPADS.	Hydrogen	102-104	chemokine (C-X-C motif) ligand 2	Mus musculus	0-5
20150709-1	2010	The single-chamber membrane-less MEC exerted much better hydrogen production performance while given higher applied voltages than it did at lower.	Hydrogen	57-65	C-C motif chemokine ligand 28	Homo sapiens	33-36
19929851-6	2009	Multiple interactions between E2B and the enzyme include hydrogen bonds and hydrophobic interactions, as well as pi-pi interactions.	Hydrogen	57-65	dihydrolipoamide branched chain transacylase E2	Homo sapiens	30-33
19766594-3	2009	The hCB1(TMH7/H8) NMR solution structure suggests multiple electrostatic amino-acid interactions, including an intrahelical H8 salt bridge and a hydrogen-bond network involving the peptide"s loop-like region.	Hydrogen	145-153	cannabinoid receptor 1	Homo sapiens	4-8
19480423-1	2009	Time-dependent density functional theory method was performed to investigate the intramolecular and intermolecular hydrogen bonding in both the singlet and triplet electronic excited states of aminofluorenones AF, MAF, and DMAF in alcoholic solutions as well as their important roles on the excited-state photophysical processes of these aminofluorenones, such as internal conversion, intersystem crossing (ISC), twisted intramolecular charge transfer (TICT), and so forth.	Hydrogen	115-123	MAF bZIP transcription factor	Homo sapiens	214-217
19480423-2	2009	The intramolecular hydrogen bond C=O...H-N can be formed between the carbonyl group and amino group for the isolated AF and MAF.	Hydrogen	19-27	MAF bZIP transcription factor	Homo sapiens	124-127
19480423-5	2009	The formation of intramolecular hydrogen bond for AF and MAF is tightly associated with the intersystem crossing of these aminofluorenones.	Hydrogen	32-40	MAF bZIP transcription factor	Homo sapiens	57-60
19480423-7	2009	Since the change of hydrogen bond between S(1) and T(1) states of AF is stronger than that of MAF, the rate of ISC process for AF is faster than that for MAF.	Hydrogen	20-28	MAF bZIP transcription factor	Homo sapiens	94-97
19480423-7	2009	Since the change of hydrogen bond between S(1) and T(1) states of AF is stronger than that of MAF, the rate of ISC process for AF is faster than that for MAF.	Hydrogen	20-28	MAF bZIP transcription factor	Homo sapiens	154-157
19480423-11	2009	At the same time, the change of intermolecular hydrogen bond between S(1) and T(1) states for AF is much stronger than that for MAF, which may also contribute to the faster ISC process for AF than that for MAF in the same solvents.	Hydrogen	47-55	MAF bZIP transcription factor	Homo sapiens	128-131
19480423-11	2009	At the same time, the change of intermolecular hydrogen bond between S(1) and T(1) states for AF is much stronger than that for MAF, which may also contribute to the faster ISC process for AF than that for MAF in the same solvents.	Hydrogen	47-55	MAF bZIP transcription factor	Homo sapiens	206-209
20059115-8	2009	Finally, the Raman susceptibility of sugar/water solutions and the calculated VDOS of water in the different lysozyme solutions confirm that sugars induce a significant strengthening of the hydrogen bond network of water that may stabilize proteins at high temperatures.	Hydrogen	190-198	lysozyme	Homo sapiens	109-117
19928840-7	2009	Then, in a homolytic pathway, two Co(III)-hydrides react in a bimolecular step to eliminate H(2).	Hydrogen	92-96	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	34-40
19928840-8	2009	Alternatively, in a heterolytic pathway, protonation of the Co(III)-hydride produces H(2) and Co(III).	Hydrogen	85-89	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	60-66
20000643-5	2009	It appears that partial derivatization on the CF6 molecule disrupts the molecular internal hydrogen bonding, thereby making the core of the molecule more accessible.	Hydrogen	91-99	ATP synthase peripheral stalk subunit F6	Homo sapiens	46-49
19779467-2	2009	The aim of the study was to assess 24-h blood pressure (BP) change after Ca2+ supplementation and to investigate its relation to changes in intracellular ions and the activity of the first isoform of sodium-hydrogen exchange (NHE-1) in subjects with hypertension and type 2 diabetes.	Hydrogen	207-215	solute carrier family 9 member A1	Homo sapiens	226-231
19766097-3	2009	Using rat RBL-2H3 mast cells, we demonstrated that hydrogen attenuates phosphorylation of the FcepsilonRI-associated Lyn and its downstream signal transduction, which subsequently inhibits the NADPH oxidase activity and reduces the generation of hydrogen peroxide.	Hydrogen	51-59	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	117-120
19504174-5	2009	Molecular modeling suggested that myricetin easily docks to the ATP-binding site of Akt with hydrogen bonds.	Hydrogen	93-101	AKT serine/threonine kinase 1	Homo sapiens	84-87
19798736-3	2009	We demonstrate that the three motifs interact in a similar way with the EH-domain of EHD1, with the NPF motif having the highest affinity due to the presence of an intermolecular hydrogen bond.	Hydrogen	179-187	EH domain containing 1	Homo sapiens	85-89
19754428-4	2009	It can tightly accommodate one extended NAG molecule having the delta-COO- at the pocket entry, the alpha-COO- and acetamido groups tightly hydrogen bonded to the pocket, and the terminal methyl of the acetamido substituent surrounded by hydrophobic residues.	Hydrogen	140-148	N-acetyl-alpha-glucosaminidase	Homo sapiens	40-43
19924250-8	2009	The position of WAT1, which hydrogen bonds to both the catalytic aspartates, is different from when there is no substrate bound in the active site.	Hydrogen	28-36	MTOR associated protein, LST8 homolog	Homo sapiens	16-20
19924250-13	2009	This structure further suggests that to achieve the goal of designing inhibitors mimicking the transition-state, the hydrogen-bonding pattern between WAT1 and the enzyme should be replicated.	Hydrogen	117-125	MTOR associated protein, LST8 homolog	Homo sapiens	150-154
19635794-2	2009	We compared the dynamic properties of 13 as-isolated, partially metallated, SOD1 variant enzymes using hydrogen-deuterium exchange.	Hydrogen	103-111	superoxide dismutase 1	Homo sapiens	76-80
19850866-0	2009	Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry.	Hydrogen	63-71	apolipoprotein A1	Homo sapiens	41-59
19739677-0	2009	Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange.	Hydrogen	84-92	estrogen receptor 1	Homo sapiens	39-62
19751177-7	2009	Moreover, the reason for high binding efficiency of trastuzumab with mutant ErbB2 is due to additional hydrogen bonding of amino acid Asn30 of trastuzumab with Asp596 and Glu598 of ErbB2 receptor of mutant type.	Hydrogen	103-111	erb-b2 receptor tyrosine kinase 2	Homo sapiens	76-81
19751177-7	2009	Moreover, the reason for high binding efficiency of trastuzumab with mutant ErbB2 is due to additional hydrogen bonding of amino acid Asn30 of trastuzumab with Asp596 and Glu598 of ErbB2 receptor of mutant type.	Hydrogen	103-111	erb-b2 receptor tyrosine kinase 2	Homo sapiens	181-186
19767119-5	2009	IL-1beta treatment for 1h activated JNK and resulted in both post-translational modification and reduction of nuclear RXRalpha.	Hydrogen	23-25	interleukin 1 beta	Mus musculus	0-8
19919165-10	2009	They also show strong intermolecular interactions through C(sp(2))-H...F-C(sp(2)) hydrogen bonds.	Hydrogen	82-90	regulator of calcineurin 2	Homo sapiens	58-65
19831442-0	2009	The ejection of triatomic molecular hydrogen ions H(3) (+) produced by the interaction of benzene molecules with ultrafast laser pulses.	Hydrogen	36-44	H3 clustered histone 14	Homo sapiens	50-54
19810732-0	2009	Hydrogen storage properties of nanosized MgH2-0.1TiH2 prepared by ultrahigh-energy-high-pressure milling.	Hydrogen	0-8	RuvB like AAA ATPase 2	Homo sapiens	49-53
19726542-2	2009	The present study tested the hypothesis that the microtubule- rather than the clathrin-dependent endocytic pathway regulates AT1-mediated uptake of ANG II and ANG II-induced sodium and hydrogen exchanger-3 (NHE-3) expression in PT cells.	Hydrogen	185-193	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	159-165
19831442-2	2009	The H(3) (+) formation can only take place through the rupture of two C-H bonds and the migration of hydrogen atoms within the molecular structure.	Hydrogen	101-109	H3 clustered histone 14	Homo sapiens	4-8
19754085-6	2009	Effects of metal cations on the UV-vis absorption spectra of the alpha-Toc* (and ArO*) radical were negligible in methanol solution, suggesting that the complex formation between the alpha-Toc* (and ArO*) radical molecule and metal cations is hindered by the hydrogen bond between radical and methanol molecules.	Hydrogen	259-267	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	81-85
19831442-4	2009	The relative ejection efficiency of H(3) (+) molecular hydrogen ions with respect to the atomic ones is found to be strongly decreasing as a function of the laser intensity and pulse duration (67-25 fs).	Hydrogen	55-63	H3 clustered histone 14	Homo sapiens	36-40
19754085-6	2009	Effects of metal cations on the UV-vis absorption spectra of the alpha-Toc* (and ArO*) radical were negligible in methanol solution, suggesting that the complex formation between the alpha-Toc* (and ArO*) radical molecule and metal cations is hindered by the hydrogen bond between radical and methanol molecules.	Hydrogen	259-267	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	199-203
19754085-7	2009	The results indicate that the hydrogen transfer reaction of alpha-TocH proceeds via an electron transfer intermediate from alpha-TocH to ArO* radicals followed by proton transfer.	Hydrogen	30-38	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	137-141
19770501-5	2009	The hydrogen bonds in the insulin molecules, as well as those involving HisB10 and GluB13, are discussed.	Hydrogen	4-12	insulin	Homo sapiens	26-33
19770501-6	2009	The hydrogen/deuterium (H/D) exchange ratios of the amide H atoms of T(6) porcine insulin in crystals were obtained and showed that regions highly protected from H/D exchange are concentrated in the centre of a helical region of the B chains.	Hydrogen	4-12	insulin	Homo sapiens	82-89
19655253-7	2009	The inhibited structure of caspase-7/YVAD shows that the P4 Tyr binds the S4 region specific to polar residues at the expense of a main chain hydrogen bond between the P4 amide and carbonyl oxygen of caspase-7 Gln 276, which is similar to the caspase-3 complex.	Hydrogen	142-150	caspase 3	Homo sapiens	243-252
19726185-3	2009	The five pharmacophore features of Hypo1, including three hydrophobic groups, one hydrogen-bond acceptor, and one hydrophobic aromatic group, were correctly mapped onto NF-kappaB surface.	Hydrogen	82-90	nuclear factor kappa B subunit 1	Homo sapiens	169-178
19748127-0	2009	Directly observed hydrogen bonds at calcium-binding-sites of calmodulin in solution relate to affinity of the calcium-binding.	Hydrogen	18-26	calmodulin 1	Homo sapiens	61-71
19622752-0	2009	The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors.	Hydrogen	11-19	solute carrier family 9 member A1	Homo sapiens	30-34
19665800-3	2009	Electrochemical data in methanol revealed that the Co(III)--&gt;Co(II) reduction of 1 (-0.84V vs. normal hydrogen electrode - NHE) is more positive than 2 (-1.13V vs. NHE), while it was expected to be more negative due to better sigma-donor ability of imidazole ring in HL1, compared to pyridine in HL2.	Hydrogen	105-113	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	54-57
19622752-0	2009	The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors.	Hydrogen	11-19	AKT serine/threonine kinase 1	Homo sapiens	41-44
19622752-2	2009	Substrates are generally inhibited when phosphorylated by Akt; however, we show phosphorylation of the plasma membrane sodium-hydrogen exchanger NHE1 by Akt increases exchanger activity (H(+) efflux).	Hydrogen	126-134	solute carrier family 9 member A1	Homo sapiens	145-149
19622752-2	2009	Substrates are generally inhibited when phosphorylated by Akt; however, we show phosphorylation of the plasma membrane sodium-hydrogen exchanger NHE1 by Akt increases exchanger activity (H(+) efflux).	Hydrogen	126-134	AKT serine/threonine kinase 1	Homo sapiens	153-156
19715313-0	2009	ATR-SEIRAS investigation of the Fermi level of Pt cocatalyst on a GaN photocatalyst for hydrogen evolution under irradiation.	Hydrogen	88-96	ATR serine/threonine kinase	Homo sapiens	0-3
19715313-1	2009	The interaction of photogenerated carries in GaN photocatalyst with Pt cocatalyst for hydrogen evolution under irradiation was investigated from in situ ATR-SEIRAS measurement by following the CO vibrational frequency.	Hydrogen	86-94	ATR serine/threonine kinase	Homo sapiens	153-156
19466402-7	2009	In this model, tBid binds to Bax at an interaction site formed by Bax helices alpha1, alpha2, alpha3 and alpha5 leading, due to interaction of the positively charged N-terminal fragment of tBid with anionic lipid headgroups, to Bax reorientation such that a hydrogen-bonded pair of residues, Asp98 and Ser184, is brought into close proximity with negatively charged lipid headgroups.	Hydrogen	258-266	BCL2 associated X, apoptosis regulator	Homo sapiens	29-32
19592498-0	2009	Pro-interleukin (IL)-1beta shares a core region of stability as compared with mature IL-1beta while maintaining a distinctly different configurational landscape: a comparative hydrogen/deuterium exchange mass spectrometry study.	Hydrogen	176-184	interleukin 1 beta	Homo sapiens	0-26
19615934-0	2009	Interaction of phenylbutazone and colchicine in binding to serum albumin in rheumatoid therapy: 1H NMR study.	Hydrogen	96-98	albumin	Homo sapiens	59-72
20161451-8	2009	These cooperative binding sites on interleukin-2 are correlated not only through the hydrophobic core of the protein but also through a dynamic polar network of hydrogen bonding and electrostatic interactions.	Hydrogen	161-169	interleukin 2	Homo sapiens	35-48
19624115-3	2009	Here, we employ hydrogen/deuterium exchange to probe the effects of a cavity filling mutant of alpha(1)AT.	Hydrogen	16-24	serpin family A member 1	Homo sapiens	95-105
19520144-5	2009	As early as 1h after cryoinjury, DGKzeta-immunoreactivity was greatly decreased in the afflicted cerebral cortex and almost disappeared in the necrotic core.	Hydrogen	12-14	diacylglycerol kinase zeta	Rattus norvegicus	33-40
19545622-9	2009	These results demonstrate that CaMKII plays a critical upstream role in mediating the effects of H(2)O(2) on ERK1/2, PKB, and IGF-1R phosphorylation.	Hydrogen	97-101	mitogen-activated protein kinase 3	Homo sapiens	109-115
19605362-0	2009	Actin isoform-specific conformational differences observed with hydrogen/deuterium exchange and mass spectrometry.	Hydrogen	64-72	actin	Saccharomyces cerevisiae S288C	0-5
19393615-3	2009	In this work, we have studied the peptide-membrane interactions of a model beta-sheet peptide, P(11-2) (CH(3)CO-Gln-Gln-Arg-Phe-Gln-Trp-Gln-Phe-Glu-Gln-Gln-NH(2)), by fluorescence, infrared spectroscopy, and hydrogen-deuterium exchange.	Hydrogen	208-216	proteasome 26S subunit, non-ATPase 1	Homo sapiens	95-101
19466402-8	2009	The interaction with these headgroups destabilizes the hydrogen bond which results in the release of helix alpha9 from the Bax-binding groove, its insertion into the membrane, followed by insertion into the membrane of the alpha5-alpha6 helical hairpin.	Hydrogen	55-63	BCL2 associated X, apoptosis regulator	Homo sapiens	123-126
19466402-7	2009	In this model, tBid binds to Bax at an interaction site formed by Bax helices alpha1, alpha2, alpha3 and alpha5 leading, due to interaction of the positively charged N-terminal fragment of tBid with anionic lipid headgroups, to Bax reorientation such that a hydrogen-bonded pair of residues, Asp98 and Ser184, is brought into close proximity with negatively charged lipid headgroups.	Hydrogen	258-266	BCL2 associated X, apoptosis regulator	Homo sapiens	66-69
19466402-7	2009	In this model, tBid binds to Bax at an interaction site formed by Bax helices alpha1, alpha2, alpha3 and alpha5 leading, due to interaction of the positively charged N-terminal fragment of tBid with anionic lipid headgroups, to Bax reorientation such that a hydrogen-bonded pair of residues, Asp98 and Ser184, is brought into close proximity with negatively charged lipid headgroups.	Hydrogen	258-266	BCL2 associated X, apoptosis regulator	Homo sapiens	66-69
19559571-7	2009	RESULTS: HB-EGF-induced phosphorylation of EGFR with maximum phosphorylation at 1h.	Hydrogen	80-82	epidermal growth factor receptor	Homo sapiens	43-47
19470521-7	2009	The hydrogen-bond enthalpy change responsible for the polarization on the transfer of the substrate from aqueous solution to the active site of MCAD was estimated to be approximately 15 kcal/mol.	Hydrogen	4-12	acyl-CoA dehydrogenase medium chain	Homo sapiens	144-148
19559571-9	2009	It activated Akt with maximum phosphorylation at 1h and eNOS with maximum phosphorylation at 3h.	Hydrogen	49-51	AKT serine/threonine kinase 1	Homo sapiens	13-16
19617967-0	2009	Tyrosine-67 in cytochrome c is a possible apoptotic trigger controlled by hydrogen bonds via a conformational transition.	Hydrogen	74-82	cytochrome c, somatic	Homo sapiens	15-27
19634861-4	2009	Molecular modeling suggested that the decrease of the affinity of Met-enkephalin to delta-opioid receptor could be accounted for by the loss of a single hydrogen bond.	Hydrogen	153-161	proopiomelanocortin	Homo sapiens	66-80
19616461-4	2009	The calculations indicate that all the inhibitors are able to form stable hydrogen bonds with the hALR2 active pocket which is mainly constructed by residues TYR48, HIS110 and TRP111, and they impose the inhibition effect by occupying the active space.	Hydrogen	74-82	aldo-keto reductase family 1 member B	Homo sapiens	98-103
19616461-9	2009	For each inhibitor molecule, the ionization does not change its original binding mode, but it does gradually increase the binding free energy, which reveals that besides hydrogen bonds, the electrostatic effect is also important to the inhibitor-hALR2 interaction.	Hydrogen	170-178	aldo-keto reductase family 1 member B	Homo sapiens	246-251
19469501-9	2009	In those reactions, the key mechanistic steps require hydrogen abstraction from a beta-carbon of the hydrocarbon chain (the second when counting away from the surface), and selectivity is defined by steric considerations around the different hydrogens available at those positions.	Hydrogen	54-62	amyloid beta precursor protein	Homo sapiens	80-86
19469501-9	2009	In those reactions, the key mechanistic steps require hydrogen abstraction from a beta-carbon of the hydrocarbon chain (the second when counting away from the surface), and selectivity is defined by steric considerations around the different hydrogens available at those positions.	Hydrogen	242-251	amyloid beta precursor protein	Homo sapiens	80-86
19328246-0	2009	Inventory of "slow exchanging" hydrogen atoms in human proinsulin and its derivatives: observations on the mass spectrometric analysis of deuterio-proteins in D(2)O.	Hydrogen	31-39	insulin	Homo sapiens	55-65
19603748-6	2009	Catalytic hydrosilation of alkenes by hydrogen-substituted silylene complexes [(PNP)(H)Ir=SiMes(H)][B(C(6)F(5))(4)] (1) and 14 exhibited anti-Markovnikov regioselectivity with an array of alkene substrates.	Hydrogen	38-46	purine nucleoside phosphorylase	Homo sapiens	80-83
19588971-0	2009	Exceptional stability and high hydrogen uptake in hydrogen-bonded metal-organic cubes possessing ACO and AST zeolite-like topologies.	Hydrogen	31-39	solute carrier family 17 member 5	Homo sapiens	105-108
19588971-0	2009	Exceptional stability and high hydrogen uptake in hydrogen-bonded metal-organic cubes possessing ACO and AST zeolite-like topologies.	Hydrogen	50-58	solute carrier family 17 member 5	Homo sapiens	105-108
19588971-2	2009	Accordingly, we outline the successful implementation of this strategy by reporting two ZMOFs with ACO and AST zeolite-like topologies, which were constructed from d4R BUs exclusively held together by hydrogen bonds.	Hydrogen	201-209	solute carrier family 17 member 5	Homo sapiens	107-110
19603752-2	2009	The vibronic sideband (VSB) corresponding to the OH stretching mode of waters coordinated to Gd(3+), whose frequency is inversely correlated with the strength of the hydrogen bonding to neighboring waters, exhibits an increase in frequency when Gd(3+) becomes coordinated to either EDTA, calmodulin, or mSE3 peptide.	Hydrogen	166-174	calmodulin 1	Homo sapiens	288-298
19606333-5	2009	The red shift of Pt-H stretching vibration of adsorbed hydrogen, and decrease of work function upon adsorption of H were predicted.	Hydrogen	55-63	parathyroid hormone	Homo sapiens	17-21
19328246-2	2009	Human proinsulin containing an N-terminal methionine, M-proinsulin, was engineered and converted into a perdeuterio derivative, which using an optimized mass spectrometric protocol and manual calculations gave a mass of 9669.6 (+/-1) Da showing the replacement, with deuterium of 146.4 from a total of 149 exchangeable hydrogen atoms (83 from amides and 66 from side-chains).	Hydrogen	319-327	insulin	Homo sapiens	6-16
19549187-0	2009	Quenched hydrogen/deuterium exchange NMR characterization of amyloid-beta peptide aggregates formed in the presence of Cu2+ or Zn2+.	Hydrogen	9-17	amyloid beta precursor protein	Homo sapiens	61-73
19386278-8	2009	The docking results showed that both DBP and MBP can bind in the active site of SOD and can make hydrogen bonds with the active site residue R143.	Hydrogen	97-105	superoxide dismutase 1	Homo sapiens	80-83
20055160-6	2009	The degree of interaction between vancomycin and ofloxacin is determined as follows: hydrogen bond occurring with carboxylic group at C-6 of ofloxacin and hydroxyl group of sugar part of vancomycin, the matching degree of molecular sizes of ofloxacin with the pocket in domain I of vancomycin and the hydrophobic interaction between methyl group at C-10 of piperidine group of ofloxacin and N-methyl leucine of vancomycin.	Hydrogen	85-93	homeobox C10	Homo sapiens	349-353
19553194-6	2009	Furthermore, we determined the solution structure of the CUG-BP1 RRM3 in the complex with (UG)(3) RNA, and discovered that the UGU trinucleotide is specifically recognized through extensive stacking interactions and hydrogen bonds within the pocket formed by the beta-sheet surface and the N-terminal extension.	Hydrogen	216-224	CUGBP Elav-like family member 1	Homo sapiens	57-64
19522466-5	2009	Hydrogen-deuterium exchange experiments revealed that the Fis1 arm, alpha-helix 6, and proximal loops were not protected from solvent exchange, consistent with motions on the second to minute time scale.	Hydrogen	0-8	Fis1p	Saccharomyces cerevisiae S288C	58-62
19298826-4	2009	Changes in the rate of hydrogen exchange indicate that ATP binding causes conformational rearrangements of Arp2 and Arp3 that are transmitted allosterically to the Arp complex (ARPC)1, ARPC2, ARPC4, and ARPC5 subunits.	Hydrogen	23-31	actin related protein 2/3 complex subunit 4	Homo sapiens	192-197
19566094-5	2009	Spectroscopic study of photolysis solutions suggests that hydrogen production occurs through protonation of a Co(I) species to give a Co(III) hydride, which then reacts further by reduction and protolysis to give Co(II) and molecular hydrogen.	Hydrogen	58-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	213-219
19496616-3	2009	We used a structural bioinformatics approach to identify two selectivity elements encoded by the TXXXG sequence motif on the p38alpha kinase hinge: (i) Thr106 that serves as the gatekeeper to the buried hydrophobic pocket occupied by 2,4-difluorophenyl of PH-797804 and (ii) the bidentate hydrogen bonds formed by the pyridinone moiety with the kinase hinge requiring an induced 180 degrees rotation of the Met109-Gly110 peptide bond.	Hydrogen	289-297	mitogen-activated protein kinase 14	Homo sapiens	125-133
19439417-1	2009	The light-activated enzyme NADPH-protochlorophyllide oxidoreductase (POR) catalyzes the trans addition of hydrogen across the C-17-C-18 double bond of protochlorophyllide (Pchlide), a key step in chlorophyll biosynthesis.	Hydrogen	106-114	cytochrome p450 oxidoreductase	Homo sapiens	27-67
19439417-1	2009	The light-activated enzyme NADPH-protochlorophyllide oxidoreductase (POR) catalyzes the trans addition of hydrogen across the C-17-C-18 double bond of protochlorophyllide (Pchlide), a key step in chlorophyll biosynthesis.	Hydrogen	106-114	cytochrome p450 oxidoreductase	Homo sapiens	69-72
19505100-0	2009	Thermal decay of rhodopsin: role of hydrogen bonds in thermal isomerization of 11-cis retinal in the binding site and hydrolysis of protonated Schiff base.	Hydrogen	36-44	rhodopsin	Homo sapiens	17-26
19398208-5	2009	At 0.5h, 1h, 3h and 6h of acute myocardial ischemia/infarction, TNF-alpha was mainly up-regulated in a sub-population of small and medium neurons and satellite cells in the dorsal root ganglia (DRG) and spinal neurons, mainly in laminae I, II and V, VI of the spinal dorsal horn of upper thoracic segments.	Hydrogen	9-11	tumor necrosis factor	Rattus norvegicus	64-73
19539480-9	2009	In this model, NI241 forms three hydrogen bonds with Tyr60, His144, and Asp242 on p50, which are important amino acid residues for the interaction with DNA.	Hydrogen	33-41	nuclear factor kappa B subunit 1	Homo sapiens	82-85
19505100-5	2009	These results provide insight into understanding the critical role of an extensive hydrogen-bonding network on stabilizing the inactive state of rhodopsin and contribute to our current understanding of the low dark noise level of rhodopsin, which enables this specialized protein to function as an extremely sensitive biological light detector.	Hydrogen	83-91	rhodopsin	Homo sapiens	145-154
19505100-5	2009	These results provide insight into understanding the critical role of an extensive hydrogen-bonding network on stabilizing the inactive state of rhodopsin and contribute to our current understanding of the low dark noise level of rhodopsin, which enables this specialized protein to function as an extremely sensitive biological light detector.	Hydrogen	83-91	rhodopsin	Homo sapiens	230-239
19505100-6	2009	Because similar hydrogen-bonding networks have also been suggested by structural analysis of two other GPCRs, beta1 and beta2 adrenergic receptors, our results could reveal a general role of hydrogen bonds in facilitating GPCR function.	Hydrogen	16-24	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	110-115
19505100-6	2009	Because similar hydrogen-bonding networks have also been suggested by structural analysis of two other GPCRs, beta1 and beta2 adrenergic receptors, our results could reveal a general role of hydrogen bonds in facilitating GPCR function.	Hydrogen	191-199	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	110-115
19462409-0	2009	Conformational changes in Akt1 activation probed by amide hydrogen/deuterium exchange and nano-electrospray ionization mass spectrometry.	Hydrogen	58-66	AKT serine/threonine kinase 1	Homo sapiens	26-30
19916462-0	2009	First principle study of hydrogenation of MgB2: an important step toward reversible hydrogen storage in the coupled LiBH4/MgH2 system.	Hydrogen	25-33	secretoglobin family 2A member 1	Homo sapiens	42-46
19916462-6	2009	By using ab initio density functional theory calculations, we found that the activation barrier for the dissociation of H2 are 0.49 and 0.58 eV for the B and Mg-terminated MgB2(0001) surface, respectively.	Hydrogen	120-122	secretoglobin family 2A member 1	Homo sapiens	172-176
19916462-7	2009	This implies that the dissociation kinetics of H2 on a MgB2(0001) surface should be greatly improved compared to that in pure Mg materials.	Hydrogen	47-49	secretoglobin family 2A member 1	Homo sapiens	55-59
19523979-5	2009	A short exposure (1h) to cadmium (25-100 microM), followed by several hours of recovery, produced a predominant apoptotic mechanism of cell death, involving the mitochondrial intrinsic pathway, as evidenced by nuclear condensation, DNA fragmentation, bax integration into the outer mitochondrial membrane, cytochrome c release, and activation of caspases-9 and -3.	Hydrogen	18-20	BCL2 associated X, apoptosis regulator	Homo sapiens	251-254
19523979-5	2009	A short exposure (1h) to cadmium (25-100 microM), followed by several hours of recovery, produced a predominant apoptotic mechanism of cell death, involving the mitochondrial intrinsic pathway, as evidenced by nuclear condensation, DNA fragmentation, bax integration into the outer mitochondrial membrane, cytochrome c release, and activation of caspases-9 and -3.	Hydrogen	18-20	cytochrome c, somatic	Homo sapiens	306-318
19462409-1	2009	Amide hydrogen exchange coupled to nano-electrospray ionization mass spectrometry (nano-ESI-MS) has been used to identify and characterize localized conformational changes of Akt upon activation.	Hydrogen	6-14	AKT serine/threonine kinase 1	Homo sapiens	175-178
19462409-3	2009	The hydrogen/deuterium (H/D) exchange profiles revealed that Akt undergoes considerable conformational changes in the core structures of all three individual domains after activation.	Hydrogen	4-12	AKT serine/threonine kinase 1	Homo sapiens	61-64
19429262-3	2009	Cadmium induced a significant increase in STAT3 DNA-binding after 1h treatment.	Hydrogen	66-68	signal transducer and activator of transcription 3	Homo sapiens	42-47
19284778-3	2009	For one such hit class, defined by a central aminobenzylpiperidine (ABP) moiety, X-ray crystal structures of BACE mutant-disulfide conjugates revealed that the fragment bound by engaging both catalytic aspartates with hydrogen bonds.	Hydrogen	218-226	beta-secretase 1	Homo sapiens	109-113
19406128-2	2009	Based on the electron crystallographic structure of AQP1, the hydrogen-bond isolation mechanism was proposed to explain why AQPs are impermeable to protons despite their very fast water conduction.	Hydrogen	62-70	aquaporin 1 (Colton blood group)	Homo sapiens	52-56
19432395-1	2009	The PsaC subunit of Photosystem I (PS I) is tightly bound to the PsaA/PsaB heterodimer via an extensive network of ionic and hydrogen bonds.	Hydrogen	125-133	fatty acid amide hydrolase	Homo sapiens	70-74
19415897-1	2009	Mutagenesis data suggest that BNIP3 transmembrane domain dimerization depends critically on hydrogen bonding between His 173 and Ser 172, but a recent structural analysis indicates that these residues adopt multiple conformations and are not always hydrogen bonded.	Hydrogen	92-100	BCL2 interacting protein 3	Homo sapiens	30-35
19462037-4	2009	MD calculations indicate a population of conformers which adopt folded beta turn structures for all the L-peptides; on the other hand, a D-stereochemistry at the Pro residue induces a natural folding towards a beta hairpin conformation driven by the formation of a second hydrogen bond, regardless of the stereochemistry of the stereogenic peptide bond surrogate.	Hydrogen	272-280	amyloid beta precursor protein	Homo sapiens	208-214
19289094-3	2009	The goal of this study was to define and optimize quantitation of different amounts of tryptic peptides derived from PE using light (H4, 4 hydrogens) and heavy (D4, 4 deuteriums) succinic anhydride for isotopic labeling of peptides analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS).	Hydrogen	139-148	proenkephalin	Homo sapiens	117-119
19345287-1	2009	The tescalcin gene (Tesc) encodes an EF-hand calcium-binding protein that interacts with the sodium/hydrogen exchanger, NHE1.	Hydrogen	100-108	tescalcin	Mus musculus	4-13
19636946-0	2009	1H, 13C and 15N resonance assignments of the human filamin A tandem immunoglobulin-like domains 16-17 and 18-19.	Hydrogen	0-2	filamin A	Homo sapiens	51-60
19636965-0	2009	Sequence-specific 1H, 13C, and 15N resonance assignment of the autophagy-related protein Atg8.	Hydrogen	18-20	GABA type A receptor associated protein like 1	Homo sapiens	89-93
19345287-1	2009	The tescalcin gene (Tesc) encodes an EF-hand calcium-binding protein that interacts with the sodium/hydrogen exchanger, NHE1.	Hydrogen	100-108	tescalcin	Mus musculus	20-24
19345287-1	2009	The tescalcin gene (Tesc) encodes an EF-hand calcium-binding protein that interacts with the sodium/hydrogen exchanger, NHE1.	Hydrogen	100-108	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	120-124
19422184-0	2009	Theoretical investigation of the interaction between fluorinated dimethyl ethers (nF = 1-5) and water: role of the acidity and basicity on the competition between OH...O and CH...O hydrogen bonds.	Hydrogen	181-189	neurofibromin 1	Homo sapiens	82-90
19422190-5	2009	The ratio of the rate constants (333 K) for the cyanoisopropyl radical (*C(CH(3))(2)CN) adding with monomer (k(1)) to the process of transferring a hydrogen atom to (TMP)Co(II)* (k(2)) was evaluated for the methyl acrylate system as 2 x 10(-3) which is larger than that for vinyl acetate LRP (9 x 10(-5)).	Hydrogen	148-156	LDL receptor related protein 1	Homo sapiens	288-291
19308329-0	2009	NMR investigations on residue level unfolding thermodynamics in DLC8 dimer by temperature dependent native state hydrogen exchange.	Hydrogen	113-121	dynein light chain LC8-type 1	Homo sapiens	64-68
19405066-1	2009	Probing the sheet: The network of hydrogen bonds formed in the outer beta sheet of the nicotinic acetylcholine receptor (nAChR; see figure) is fairly robust and tolerates single amide-to-ester mutations throughout.	Hydrogen	34-42	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	87-119
19405066-1	2009	Probing the sheet: The network of hydrogen bonds formed in the outer beta sheet of the nicotinic acetylcholine receptor (nAChR; see figure) is fairly robust and tolerates single amide-to-ester mutations throughout.	Hydrogen	34-42	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	121-126
19405066-2	2009	However, eliminating two proximal hydrogen bonds completely destroys receptor function; this adds further support to gating models that ascribe important roles to these beta strands of the nAChR extracellular domain.Long-range communication is essential for the function of members of the Cys-loop family of neurotransmitter-gated ion channels.	Hydrogen	34-42	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	189-194
19408261-3	2009	Formation of hydrogen bonds upon helix folding could contribute significantly to the enhanced enthalpy observed in binding of the linear peptides.The human double minute 2 protein (HDM2) binds a short peptide derived from the N terminus of the tumor-suppressor protein, p53.	Hydrogen	13-21	tumor protein p53	Homo sapiens	270-273
19419220-11	2009	A higher number of salt bridges and hydrogen bonds (H bonds) between POPA and the alpha4beta2 nAChR were found in the open system than in the closed system, suggesting a potential role of POPA in the equilibrium between different channel states.	Hydrogen	36-44	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	94-99
19425788-8	2009	A flexible water model, extending the rigid SPC/E, is proposed, which incorporates Lennard-Jones interactions centered on the hydrogen atoms.	Hydrogen	126-134	proline rich protein gene cluster	Homo sapiens	44-47
19178384-6	2009	Furthermore, we characterized in detail the hydrogen-bond network and electrostatic interactions between charged groups in INSL5 by NMR-monitored temperature and pH titrations and undertook a comprehensive structural comparison with other members of the relaxin family, thus identifying the conserved structural features of the relaxin fold.	Hydrogen	44-52	insulin like 5	Homo sapiens	123-128
19200750-1	2009	This work uses electrospray ionization mass spectrometry (ESI-MS) in conjunction with hydrogen/deuterium exchange (HDX) and optical spectroscopy for characterizing the solution-phase properties of cytochrome c (cyt c) after heat exposure.	Hydrogen	86-94	cytochrome c, somatic	Homo sapiens	197-209
19324057-0	2009	Existence of a noncanonical state of iron-bound transferrin at endosomal pH revealed by hydrogen exchange and mass spectrometry.	Hydrogen	88-96	transferrin	Homo sapiens	48-59
19324057-3	2009	In this work, hydrogen/deuterium exchange was used in combination with mass spectrometry to map solvent-accessible surfaces of the iron-bound and iron-free forms of the N-terminal lobe of human serum Tf at both neutral and endosomal pH levels.	Hydrogen	14-22	transferrin	Homo sapiens	200-202
19385626-11	2009	H250A and H250F mutations of P450 StaP show that His(250) is important, but in its absence Wat(644) and Wat(789) form a hydrogen-bonding diad that mediates the transformation.	Hydrogen	120-128	cytoglobin	Homo sapiens	34-38
19673942-4	2009	The aim of the present study was to investigate the cellular expression and distribution of inducible nitric oxide synthase (iNOS) using immunohistochemistry in lung, heart and kidney tissues from a model of human hypertension using male and female double-transgenic (h-Ang 204/1h-Ren6) mice and wild-type C57/BI6J mice as controls.	Hydrogen	278-280	nitric oxide synthase 2	Homo sapiens	92-123
19673942-4	2009	The aim of the present study was to investigate the cellular expression and distribution of inducible nitric oxide synthase (iNOS) using immunohistochemistry in lung, heart and kidney tissues from a model of human hypertension using male and female double-transgenic (h-Ang 204/1h-Ren6) mice and wild-type C57/BI6J mice as controls.	Hydrogen	278-280	nitric oxide synthase 2	Homo sapiens	125-129
19308329-3	2009	In this regard, we describe here the NMR investigations on the conformational stabilities and related thermodynamic parameters such as local unfolding enthalpies, heat capacities and transition midpoints in DLC8 dimer, by using temperature dependent native state hydrogen exchange; this protein aggregates at high (&gt;65 degrees C) temperatures.	Hydrogen	263-271	dynein light chain LC8-type 1	Homo sapiens	207-211
19085022-3	2009	Furthermore, the docking results of the ligands (allosamidin and NAG(2)) into the active site of hAMCase indicate that allosamidin is a more preferred ligand than NAG(2), and that Glu119 forms hydrogen bond with allosamidin, which is in good agreement with the experimental results.	Hydrogen	193-201	chitinase acidic	Homo sapiens	97-104
19301816-0	2009	Role of the hydrogen bonding heteroatom-Lys53 interaction between the p38alpha mitogen-activated protein (MAP) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors.	Hydrogen	12-20	mitogen-activated protein kinase 14	Homo sapiens	70-78
19207107-8	2009	An insert of 29 amino acid residues, present only in mammalian PBGD enzymes, has been modelled into domain 3 where it extends helix alpha2(3) and forms a beta-hairpin structure that contributes to a continuous hydrogen-bonding network spanning domains 1 and 3.	Hydrogen	210-218	hydroxymethylbilane synthase	Homo sapiens	63-67
19136720-0	2009	Functional unfolding of alpha1-antitrypsin probed by hydrogen-deuterium exchange coupled with mass spectrometry.	Hydrogen	53-61	serpin family A member 1	Bos taurus	24-42
19391610-4	2009	Fractured nanowires continued to function as sensors for H(2) concentrations above 2%, actuated by the volume change associated with the alpha to beta phase transition of PdH(x).	Hydrogen	57-61	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	171-174
19249875-0	2009	Role of the hydrogen bond from Leu722 to the A1A phylloquinone in photosystem I. Photosystem I (PS I) contains two molecules of phylloquinone that function as electron transfer cofactors at highly reducing midpoint potentials.	Hydrogen	12-20	serpin family A member 1	Homo sapiens	45-48
19334714-8	2009	The complex exhibits unique hydrogen bonding between Haic and Gln and Stat3 as well as hydrophobic interactions between the protein and pCinn and Haic.	Hydrogen	28-36	signal transducer and activator of transcription 3	Homo sapiens	70-75
19260709-5	2009	An X-ray crystal structure of R388A Src revealed the surprising finding that a histidine residue of the N-terminus of a symmetry-related kinase inserts into the active site of the adjacent Src and mimics the hydrogen-bonding pattern seen in wild-type protein tyrosine kinases.	Hydrogen	208-216	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	36-39
19260709-5	2009	An X-ray crystal structure of R388A Src revealed the surprising finding that a histidine residue of the N-terminus of a symmetry-related kinase inserts into the active site of the adjacent Src and mimics the hydrogen-bonding pattern seen in wild-type protein tyrosine kinases.	Hydrogen	208-216	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	189-192
19181663-8	2009	Molecular dynamics results showed that the ordinal increase in flexibility from pseudolysin to MCP-02 and E495, especially the increase from MCP-02 to E495, mainly resulted from the decrease of hydrogen-bond stability in the dynamic structure, which was due to the increase in asparagine, serine, and threonine residues.	Hydrogen	194-202	CD46 molecule	Homo sapiens	95-98
19301917-8	2009	Finally, {Nb(mu-N)(2)Nb}(2-) is generated after H(2) elimination in which the N-bonded H atom is coupled with the remaining mu-H atom.	Hydrogen	48-52	familial progressive hyperpigmentation 1	Homo sapiens	124-128
19249288-7	2009	RESULTS: Hydrogen-rich saline treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-kappaB activation and the pro-inflammatory cytokine interleukin IL-1beta and TNF-alpha in the lung tissues compared with those in saline-treated rat.	Hydrogen	9-17	interleukin 1 beta	Rattus norvegicus	179-187
19249288-7	2009	RESULTS: Hydrogen-rich saline treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-kappaB activation and the pro-inflammatory cytokine interleukin IL-1beta and TNF-alpha in the lung tissues compared with those in saline-treated rat.	Hydrogen	9-17	tumor necrosis factor	Rattus norvegicus	192-201
19181663-8	2009	Molecular dynamics results showed that the ordinal increase in flexibility from pseudolysin to MCP-02 and E495, especially the increase from MCP-02 to E495, mainly resulted from the decrease of hydrogen-bond stability in the dynamic structure, which was due to the increase in asparagine, serine, and threonine residues.	Hydrogen	194-202	CD46 molecule	Homo sapiens	141-144
19226157-1	2009	We report here that the monodentate complexation of Me2AlCl to an ester group significantly enhances the selectivity of hydrogen transfer on acyclic radicals flanked by both an ester functionality and a stereogenic center, leading to C-2,C-3-anti products with high diastereoselectivity.	Hydrogen	120-128	malic enzyme 2	Homo sapiens	52-55
19275142-0	2009	Dynamical behavior of the H2 molecule of the PtH(H2)[P(t-Bu)3]2(+) complex.	Hydrogen	26-28	parathyroid hormone	Homo sapiens	45-48
18767155-0	2009	Residue-wise conformational stability of DLC8 dimer from native-state hydrogen exchange.	Hydrogen	70-78	dynein light chain LC8-type 1	Homo sapiens	41-45
18767155-6	2009	We deduce from the free energy data that the antiparallel beta-sheets (beta4 and beta5) that form the hydrophobic core of the protein and the alpha2 helix, all of which are highly protected with regard to hydrogen exchange, contribute significantly to the initial step of the protein folding mechanism.	Hydrogen	205-213	adaptor related protein complex 4 subunit beta 1	Homo sapiens	71-86
19185916-1	2009	This study compares the effect of an acute stressor (restraint for 1h) versus a chronic stressor (social isolation for 4 weeks) on the expression of mRNAs for corticotropin-releasing hormone (CRH), CRH receptor type 1 (CRH-R1) and type 2 (CRH-R2) in the hypothalamus, hippocampus and pituitary of socially monogamous female prairie voles (Microtus ochrogaster).	Hydrogen	67-69	corticoliberin	Microtus ochrogaster	159-190
19185916-1	2009	This study compares the effect of an acute stressor (restraint for 1h) versus a chronic stressor (social isolation for 4 weeks) on the expression of mRNAs for corticotropin-releasing hormone (CRH), CRH receptor type 1 (CRH-R1) and type 2 (CRH-R2) in the hypothalamus, hippocampus and pituitary of socially monogamous female prairie voles (Microtus ochrogaster).	Hydrogen	67-69	corticoliberin	Microtus ochrogaster	198-201
19004647-5	2009	We applied human recombinant IL-1beta intra-nasally 1h before seizures induced by moist warm air.	Hydrogen	52-54	interleukin 1 beta	Homo sapiens	29-37
19275264-7	2009	For both catenanes and rotaxanes, removal of the metal ion via reduction under acidic conditions to the more labile Co(II) gave neutral interlocked molecules with well-defined co-conformations stabilized by intercomponent hydrogen bonding.	Hydrogen	222-230	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-122
19231824-0	2009	Dynamical binding of hydrogen-bond surrogate derived Bak helices to antiapoptotic protein Bcl-xL.	Hydrogen	21-29	BCL2 like 1	Homo sapiens	90-96
19161286-8	2009	Furthermore, independent distant homology modeling indicated that DmKAP may bind along the coiled-coil stalks through a combination of predominantly hydrophobic interactions and hydrogen bonds.	Hydrogen	178-186	Kinesin associated protein 3	Drosophila melanogaster	66-71
19161338-0	2009	TbetaR-II discriminates the high- and low-affinity TGF-beta isoforms via two hydrogen-bonded ion pairs.	Hydrogen	77-85	transforming growth factor beta 1	Homo sapiens	51-59
19161338-9	2009	Substitution of Arg25 and Arg94 with alanine verified the requirement of the arginine guanidinium functional groups for the highly specific hydrogen-bonded ion pairs formed between Arg25 and Arg94 of TGF-beta1 and -beta3, and Glu119 and Asp32 of TbetaR-II.	Hydrogen	140-148	transforming growth factor beta 1	Homo sapiens	200-220
19420447-7	2009	The vertical rate of growth can reach 300 nm min(-1) in an environment containing argon, hydrogen, and traces of water vapour.	Hydrogen	89-97	CD59 molecule (CD59 blood group)	Homo sapiens	45-51
19095394-6	2009	At all the magnesium concentrations studied, the DeltaH values were negative due to van der Waals interactions and hydrogen bonding which are engaged at the complex interface confirming strong TT-SHBG hydrogen bond networks.	Hydrogen	201-209	sex hormone binding globulin	Homo sapiens	196-200
19437788-7	2009	In the single crystals of C10-DFQA and C16-DFQA, the molecules assembled into 2-D molecular sheets based on the hydrogen bonds and C-H...pi interactions.	Hydrogen	112-120	homeobox C10	Homo sapiens	26-34
19317814-0	2009	Insulin sensitivity increase after calcium supplementation and change in intraplatelet calcium and sodium-hydrogen exchange in hypertensive patients with Type 2 diabetes.	Hydrogen	106-114	insulin	Homo sapiens	0-7
21783944-3	2009	HEK 293 cells were cultured in 96-well plates and then pretreated with or without 20muM acetaminophen (IC(50) value: 17.5+-1.9) for 1h.	Hydrogen	132-134	latexin	Homo sapiens	84-87
19173595-3	2009	Therefore, the goal of this study was to investigate the relative accessibilities of multiple dibasic processing sites of PE by peptide amide hydrogen-deuterium exchange mass spectrometry (DXMS).	Hydrogen	142-150	proenkephalin	Homo sapiens	122-124
19173595-5	2009	DXMS assesses relative rates of exchange of hydrogens of the polypeptide backbone of PE with deuterium atoms from D(2)O (heavy water) in solvent.	Hydrogen	44-53	proenkephalin	Homo sapiens	85-87
19173595-9	2009	The hydrogen exchange rate profile of PE, as well as its circular dichroism (CD) features for secondary structure, was modified in trifluoroethanol, an organic solvent that represents a more hydrophobic environment.	Hydrogen	4-12	proenkephalin	Homo sapiens	38-40
18722033-7	2009	Moreover, hydrogen bond interactions involving residues Met343, Asp406 and Ser347 emerged as playing a key role in determining the affinity of the active inhibitors toward c-Src.	Hydrogen	10-18	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	172-177
19157885-0	2009	Interaction study of bioactive molecules with fibrinogen and human platelets determined by 1H NMR relaxation experiments.	Hydrogen	91-93	fibrinogen beta chain	Homo sapiens	46-56
19145608-0	2009	1H[19F] NOE NMR structural signatures of the insulin R6 hexamer: evidence of a capped HisB10 site in aryl- and arylacryloyl-carboxylate complexes.	Hydrogen	0-2	insulin	Homo sapiens	45-52
19022458-4	2009	The presence of the barbituric acid in subphase change the hydrophilicity of 2PDI-TAZ due to the hydrogen bonding between melamine and barbituric acid, which has been revealed by the pi-A isotherms and the FT-IR spectra.	Hydrogen	97-105	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	82-85
19145608-1	2009	NEW AND IMPROVED INSULIN: 1H[19F] NOE NMR difference spectra for CF(3)-substituted aromatic carboxylates bound at the HisB10 sites of the R(6) human insulin (HI) hexamer show strong NOEs between the CF(3) groups and the LeuB6, AsnB3, and PheB1 sidechains.	Hydrogen	26-28	insulin	Homo sapiens	17-24
19145608-1	2009	NEW AND IMPROVED INSULIN: 1H[19F] NOE NMR difference spectra for CF(3)-substituted aromatic carboxylates bound at the HisB10 sites of the R(6) human insulin (HI) hexamer show strong NOEs between the CF(3) groups and the LeuB6, AsnB3, and PheB1 sidechains.	Hydrogen	26-28	insulin	Homo sapiens	149-156
19186145-0	2009	Structural differences between Abeta(1-40) intermediate oligomers and fibrils elucidated by proteolytic fragmentation and hydrogen/deuterium exchange.	Hydrogen	122-130	amyloid beta precursor protein	Homo sapiens	31-36
19128016-1	2009	The bioisosteric replacement of the phenol ring, a signature functional group of most estrogen receptor (ER) ligands, with a hydrogen-bonded pseudocyclic ring, led to the development of a novel class of nonsteroidal ER-ligands based on a salicylaldoxime template.	Hydrogen	125-133	estrogen receptor 1	Homo sapiens	86-103
19128016-1	2009	The bioisosteric replacement of the phenol ring, a signature functional group of most estrogen receptor (ER) ligands, with a hydrogen-bonded pseudocyclic ring, led to the development of a novel class of nonsteroidal ER-ligands based on a salicylaldoxime template.	Hydrogen	125-133	estrogen receptor 1	Homo sapiens	105-107
19128016-1	2009	The bioisosteric replacement of the phenol ring, a signature functional group of most estrogen receptor (ER) ligands, with a hydrogen-bonded pseudocyclic ring, led to the development of a novel class of nonsteroidal ER-ligands based on a salicylaldoxime template.	Hydrogen	125-133	estrogen receptor 1	Homo sapiens	216-218
19186145-3	2009	We measured the peptide level solvent accessibility of multiple Abeta(1-40) aggregated states using hydrogen exchange detected by mass spectrometry.	Hydrogen	100-108	amyloid beta precursor protein	Homo sapiens	64-69
19196184-8	2009	The affinity of NKp30 and NKp44 for synthetic HS/heparin is approximately one order of magnitude higher than the affinity of NKp46.	Hydrogen	46-48	natural cytotoxicity triggering receptor 2	Homo sapiens	26-31
19202904-6	2009	Thus, intrahepatic and intramyocellular lipids recently have been measured by 1H-MRS method as the useful markers of insulin resistance.	Hydrogen	78-80	insulin	Homo sapiens	117-124
18951722-5	2009	CRH effect was first evaluated on TRH expression of cultured hypothalamic cells where TRH mRNA levels increased after 1h with 0.1nM of CRH.	Hydrogen	118-120	corticotropin releasing hormone	Rattus norvegicus	0-3
18951722-5	2009	CRH effect was first evaluated on TRH expression of cultured hypothalamic cells where TRH mRNA levels increased after 1h with 0.1nM of CRH.	Hydrogen	118-120	corticotropin releasing hormone	Rattus norvegicus	135-138
19022677-1	2009	A novel series of androgen receptor (AR) ligands bearing an acidic heterocycle with hydrogen-bonding ability as the terminal polar group was developed.	Hydrogen	84-92	androgen receptor	Homo sapiens	18-35
19153468-7	2009	The huge change in FGF-1 stability (the denaturation temperature increased by 21.5 K, equivalent to DeltaDeltaG(den) = 24.3 kJ mol(-1)) seems to result from the formation of a short 3(10)-helix (position 40), an improvement in the propensity of amino acids to form beta-sheets (position 47) and the rearrangement of a local hydrogen-bond network (positions 47 and 93).	Hydrogen	324-332	fibroblast growth factor 1	Homo sapiens	19-24
19301342-2	2009	Variable hydrogen bonding allows two linked cyclotricatechylene clamshells to be in a closed arrangement when smaller cations such Rb(+) or Cs(+) provide the clam meat, whereas larger cations such as NMe(4) (+) and NEt(4) (+) cause the clam to be partially opened.	Hydrogen	9-17	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	200-206
19301342-2	2009	Variable hydrogen bonding allows two linked cyclotricatechylene clamshells to be in a closed arrangement when smaller cations such Rb(+) or Cs(+) provide the clam meat, whereas larger cations such as NMe(4) (+) and NEt(4) (+) cause the clam to be partially opened.	Hydrogen	9-17	tetraspanin 5	Homo sapiens	215-221
19266521-4	2009	Hydrogen transfer from (*)C(CH(3))(2)CN to [Co(II)(por)](*) proceeds via a single transition state that has structural features resembling the products [Co(H)(por)] and CH(2)=C(CH(3))CN.	Hydrogen	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
19266521-4	2009	Hydrogen transfer from (*)C(CH(3))(2)CN to [Co(II)(por)](*) proceeds via a single transition state that has structural features resembling the products [Co(H)(por)] and CH(2)=C(CH(3))CN.	Hydrogen	0-8	cytochrome p450 oxidoreductase	Homo sapiens	51-54
19266521-4	2009	Hydrogen transfer from (*)C(CH(3))(2)CN to [Co(II)(por)](*) proceeds via a single transition state that has structural features resembling the products [Co(H)(por)] and CH(2)=C(CH(3))CN.	Hydrogen	0-8	cytochrome p450 oxidoreductase	Homo sapiens	159-162
19266521-5	2009	The separated radicals approach to form a close-contact radical pair and then pass through the transition state for hydrogen-atom transfer to form [Co(III)(H)(por)] and CH(2)=C(CH(3))CN.	Hydrogen	116-124	cytochrome p450 oxidoreductase	Homo sapiens	159-162
19266521-8	2009	Insertion of vinyl acetate into the Co-H bond of [Co(III)(H)(por)] also proceeds over a low barrier (DeltaG(double dagger) = +11.4 kcal mol(-1)) hydrogen-transfer step from [Co(III)(H)(por)] to a carbon atom of the alkene to produce a close-contact radical pair.	Hydrogen	145-153	cytochrome p450 oxidoreductase	Homo sapiens	61-64
19266521-8	2009	Insertion of vinyl acetate into the Co-H bond of [Co(III)(H)(por)] also proceeds over a low barrier (DeltaG(double dagger) = +11.4 kcal mol(-1)) hydrogen-transfer step from [Co(III)(H)(por)] to a carbon atom of the alkene to produce a close-contact radical pair.	Hydrogen	145-153	cytochrome p450 oxidoreductase	Homo sapiens	185-188
19266521-10	2009	The computed energies obtained for the hydrogen-atom transfer reactions from (*)C(CH(3))(2)CN to [Co(II)(por)](*) and from [Co(H)(por)] to olefins, as well as the organo-cobalt bond homolysis energies correspond well with the experimental observations.	Hydrogen	39-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
19266521-10	2009	The computed energies obtained for the hydrogen-atom transfer reactions from (*)C(CH(3))(2)CN to [Co(II)(por)](*) and from [Co(H)(por)] to olefins, as well as the organo-cobalt bond homolysis energies correspond well with the experimental observations.	Hydrogen	39-47	cytochrome p450 oxidoreductase	Homo sapiens	105-108
19266521-10	2009	The computed energies obtained for the hydrogen-atom transfer reactions from (*)C(CH(3))(2)CN to [Co(II)(por)](*) and from [Co(H)(por)] to olefins, as well as the organo-cobalt bond homolysis energies correspond well with the experimental observations.	Hydrogen	39-47	cytochrome p450 oxidoreductase	Homo sapiens	130-133
19400096-0	2009	Thermodynamic stability and native-state dynamics of porcine pancreatic phospholipase A2 studied by 1H NMR spectroscopic measurements.	Hydrogen	100-102	phospholipase A2 group IB	Homo sapiens	72-88
19266521-0	2009	Hydrogen-atom transfer in reactions of organic radicals with [Co(II)(por)]* (por = porphyrinato) and in subsequent addition of [Co(H)(por)] to olefins.	Hydrogen	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
19266521-0	2009	Hydrogen-atom transfer in reactions of organic radicals with [Co(II)(por)]* (por = porphyrinato) and in subsequent addition of [Co(H)(por)] to olefins.	Hydrogen	0-8	cytochrome p450 oxidoreductase	Homo sapiens	69-72
19266521-0	2009	Hydrogen-atom transfer in reactions of organic radicals with [Co(II)(por)]* (por = porphyrinato) and in subsequent addition of [Co(H)(por)] to olefins.	Hydrogen	0-8	cytochrome p450 oxidoreductase	Homo sapiens	77-80
19266521-0	2009	Hydrogen-atom transfer in reactions of organic radicals with [Co(II)(por)]* (por = porphyrinato) and in subsequent addition of [Co(H)(por)] to olefins.	Hydrogen	0-8	cytochrome p450 oxidoreductase	Homo sapiens	77-80
19370743-0	2009	Alkyne-promoted H2 loss in a metallaborane: nido-to-closo cluster transformation and sp C-H bond oxidative addition.	Hydrogen	16-18	surfactant protein C	Homo sapiens	85-89
19022677-1	2009	A novel series of androgen receptor (AR) ligands bearing an acidic heterocycle with hydrogen-bonding ability as the terminal polar group was developed.	Hydrogen	84-92	androgen receptor	Homo sapiens	37-39
19022677-2	2009	Since most non-steroidal AR ligands so far known are structurally limited to nitro- or cyanobenzanilide as the polar pharmacophore, development of alternative hydrogen-bonding components is required to obtain novel AR ligands.	Hydrogen	159-167	androgen receptor	Homo sapiens	25-27
19022677-2	2009	Since most non-steroidal AR ligands so far known are structurally limited to nitro- or cyanobenzanilide as the polar pharmacophore, development of alternative hydrogen-bonding components is required to obtain novel AR ligands.	Hydrogen	159-167	androgen receptor	Homo sapiens	215-217
20408502-4	2009	Other features of CYP2F substrate binding are likely to include pi-pi stacking interactions between aromatic rings and hydrogen bonding in some cases.	Hydrogen	119-127	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	18-23
19940340-0	2009	The calcium-modulated structures of calmodulin and S100b proteins are useful to monitor hydrogen/deuterium exchange efficiency using matrix-assisted laser desorption ionization time-of-flight mass spectrometry.	Hydrogen	88-96	calmodulin 1	Homo sapiens	36-46
19957875-6	2009	Here we show a highly significant increase in expression of the alternative splice variant HIF1alpha-2 coding for a truncated 736 amino acid protein in peripheral blood derived mononuclear cells following a 1h aerobic exercise.	Hydrogen	207-209	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-100
19940340-0	2009	The calcium-modulated structures of calmodulin and S100b proteins are useful to monitor hydrogen/deuterium exchange efficiency using matrix-assisted laser desorption ionization time-of-flight mass spectrometry.	Hydrogen	88-96	S100 calcium binding protein B	Homo sapiens	51-56
19049349-6	2008	Docking of 5v, 5zf, and 5za into the binding pocket of the PDE4 catalytic domain revealed a similar binding profile to PDE4 with rolipram except that the fluorine atoms of the difluoromethyl groups of 5v, 5za, and 5zf are within a reasonable range for hydrogen bond formation with the amide hydrogen of Thr 333 and the long alkyl chain bears additional van der Waals interactions with His 160, Asp 318, and Tyr 159.	Hydrogen	252-260	phosphodiesterase 4A	Homo sapiens	59-63
19441312-1	2009	A Co(III) biuretato complex, [Co(III){ph(biu)2}]- (ph(biu)2 = o-phenylenebis(biuretato)) can form layer structures by its self-assembling with a multiply hydrogen bonding network.	Hydrogen	154-162	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	5-8
19441312-1	2009	A Co(III) biuretato complex, [Co(III){ph(biu)2}]- (ph(biu)2 = o-phenylenebis(biuretato)) can form layer structures by its self-assembling with a multiply hydrogen bonding network.	Hydrogen	154-162	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	2-9
19061913-4	2009	Interestingly, GLT-1 positive granules appear within the soma of glial cells 1h after zinc exposure, while these granules are absent in the untreated control group.	Hydrogen	77-79	solute carrier family 1 member 2	Homo sapiens	15-20
19200038-3	2009	It was found that the hydrophilic heads of these compounds form four specific conserved hydrogen bonds with the ligand binding pockets of PPARalpha and PPARgamma, which results in fixed head conformations.	Hydrogen	88-96	peroxisome proliferator activated receptor gamma	Homo sapiens	152-161
19200038-5	2009	The oxadiazole-ring-related hydrogen bond interactions well elucidate the structural features governing the different binding behavior of these agonists against PPARalpha and PPARgamma.	Hydrogen	28-36	peroxisome proliferator activated receptor gamma	Homo sapiens	175-184
18996093-6	2008	ApoE(-/-) mice drank H(2)-water ad libitum from 2 to 6 month old throughout the whole period.	Hydrogen	21-25	apolipoprotein E	Mus musculus	0-4
19049349-6	2008	Docking of 5v, 5zf, and 5za into the binding pocket of the PDE4 catalytic domain revealed a similar binding profile to PDE4 with rolipram except that the fluorine atoms of the difluoromethyl groups of 5v, 5za, and 5zf are within a reasonable range for hydrogen bond formation with the amide hydrogen of Thr 333 and the long alkyl chain bears additional van der Waals interactions with His 160, Asp 318, and Tyr 159.	Hydrogen	252-260	phosphodiesterase 4A	Homo sapiens	119-123
19049349-6	2008	Docking of 5v, 5zf, and 5za into the binding pocket of the PDE4 catalytic domain revealed a similar binding profile to PDE4 with rolipram except that the fluorine atoms of the difluoromethyl groups of 5v, 5za, and 5zf are within a reasonable range for hydrogen bond formation with the amide hydrogen of Thr 333 and the long alkyl chain bears additional van der Waals interactions with His 160, Asp 318, and Tyr 159.	Hydrogen	291-299	phosphodiesterase 4A	Homo sapiens	59-63
19049349-6	2008	Docking of 5v, 5zf, and 5za into the binding pocket of the PDE4 catalytic domain revealed a similar binding profile to PDE4 with rolipram except that the fluorine atoms of the difluoromethyl groups of 5v, 5za, and 5zf are within a reasonable range for hydrogen bond formation with the amide hydrogen of Thr 333 and the long alkyl chain bears additional van der Waals interactions with His 160, Asp 318, and Tyr 159.	Hydrogen	291-299	phosphodiesterase 4A	Homo sapiens	119-123
18930737-9	2008	There are 12 hydrogen bonds and three salt bridges between ZAG and PIP.	Hydrogen	13-21	prolactin induced protein	Homo sapiens	67-70
18973876-7	2008	Insulin and IGF-1 increased the expression of genes decreased in schizophrenia, including those involved in mitochondrial functions, glucose and energy metabolism, hydrogen ion transport, and synaptic function.	Hydrogen	164-172	insulin	Homo sapiens	0-7
18973876-7	2008	Insulin and IGF-1 increased the expression of genes decreased in schizophrenia, including those involved in mitochondrial functions, glucose and energy metabolism, hydrogen ion transport, and synaptic function.	Hydrogen	164-172	insulin like growth factor 1	Homo sapiens	12-17
18534903-7	2008	The isolated solid CoII and CoIII complexes have been characterized by elemental analyses, conductivities, spectral (IR, UV-vis, 1H NMR) and magnetic measurements.	Hydrogen	129-131	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-23
18534903-7	2008	The isolated solid CoII and CoIII complexes have been characterized by elemental analyses, conductivities, spectral (IR, UV-vis, 1H NMR) and magnetic measurements.	Hydrogen	129-131	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	28-33
18534903-8	2008	The IR spectra of the starting CoII complexes indicate that both L1 and L3 behave in bidentate manner coordinating via the carbonyl oxygen and NH2 groups, but L2 behaves as a tridentate fashion coordinating via the carbonyl oxygen, azomethine (C=N2) and SH groups with displacement of a hydrogen atom from the latter group.	Hydrogen	287-295	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-35
19079454-4	2008	Exemplary results of the simultaneous investigation of mixture formation and combustion obtained at an optical accessible hydrogen ICE are shown.	Hydrogen	122-130	carboxylesterase 2	Homo sapiens	131-134
19368019-0	2008	Reversible intramolecular hydrogen transfer between protein cysteine thiyl radicals and alpha C-H bonds in insulin: control of selectivity by secondary structure.	Hydrogen	26-34	insulin	Homo sapiens	107-114
19368019-2	2008	Here, we show that protein cysteine thiyl radicals (CysS*) can reversibly abstract hydrogen atoms from the alpha C-H bonds of selected amino acids in a protein (insulin).	Hydrogen	83-91	insulin	Homo sapiens	161-168
19636878-0	2008	Sequence-specific 1H, 13C, and 15N resonance assignments of GRP1 PH domain.	Hydrogen	18-20	cytohesin 3	Homo sapiens	60-64
18998678-4	2008	The current decrease is due to the formation of the more resistive PdH(x) in the presence of H(2).	Hydrogen	93-97	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	67-70
19007119-7	2008	The current result demonstrates the importance of electronic polarization of protein in stabilizing hydrogen bonding, which is critical to preserving the native structure of local helices and protein-ligand binding in PPAR-gamma.	Hydrogen	100-108	peroxisome proliferator activated receptor gamma	Homo sapiens	218-228
19636879-0	2008	Sequence-specific 1H, 13C and 15N backbone resonance assignments of the 34 kDa catalytic domain of human PTPN7.	Hydrogen	18-20	protein tyrosine phosphatase non-receptor type 7	Homo sapiens	105-110
19636897-0	2008	1H and 15N resonance assignment of the second fibronectin type III module of the neural cell adhesion molecule.	Hydrogen	0-2	fibronectin 1	Homo sapiens	46-57
18484636-0	2008	CH/pi hydrogen bonds determine the selectivity of the Src homology 2 domain to tyrosine phosphotyrosyl peptides: an ab initio fragment molecular orbital study.	Hydrogen	6-14	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	54-57
18635178-16	2008	EPO, a therapeutic dose in anaemic patients, applied after 1h of spinal cord injury significantly attenuated the oxidative damage of spinal cord injuries in rats.	Hydrogen	59-61	erythropoietin	Homo sapiens	0-3
18484636-2	2008	For instance, it is well known that Src homology-2 protein (SH2) recognizes its specific pTyr peptide in two key regions, pTyr-binding region and specificity-determining region, by the use of attractive molecular forces, including the CH/pi hydrogen bond.	Hydrogen	241-249	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	36-39
18767165-1	2008	In this article, we report crystal structures for inhibitor-kinase complexes in which the inhibitor has different binding orientations and hydrogen-bonding patterns with extracellular-signal regulated kinase 2 and insulin receptor tyrosine kinase.	Hydrogen	139-147	mitogen-activated protein kinase 3	Homo sapiens	170-246
18923852-5	2008	By MIAX, we deduced the amino acids and intermolecular hydrogen bonds contributing to the GPIb-vWf interaction interface.	Hydrogen	55-63	von Willebrand factor	Homo sapiens	95-98
18768384-6	2008	The 2.8-A resolution crystal structure of the ligand binding domain of human PXR in complex with colupulone was elucidated, and colupulone was observed to bind in a single orientation stabilized by both van der Waals and hydrogen bonding contacts.	Hydrogen	221-229	nuclear receptor subfamily 1 group I member 2	Homo sapiens	77-80
19043415-3	2008	The crystal structure of MBNL1 ZnF3/4 bound to r(CGCUGU) establishes that both ZnF3 and ZnF4 target GC steps, with site-specific recognition mediated by a network of hydrogen bonds formed primarily with main chain groups of the protein.	Hydrogen	166-174	zinc finger protein 3	Homo sapiens	31-35
19043415-3	2008	The crystal structure of MBNL1 ZnF3/4 bound to r(CGCUGU) establishes that both ZnF3 and ZnF4 target GC steps, with site-specific recognition mediated by a network of hydrogen bonds formed primarily with main chain groups of the protein.	Hydrogen	166-174	zinc finger protein 3	Homo sapiens	79-83
18939819-5	2008	Tests for system poisoning with mercury or CS 2 provide strong evidence that the system is a true homogeneous system for photocatalytic hydrogen production.	Hydrogen	136-144	chorionic somatomammotropin hormone 2	Homo sapiens	43-47
19031908-3	2008	Here we report an MEC-MFC-coupled system for biohydrogen production from acetate, in which hydrogen was produced in an MEC and the extra power was supplied by an MFC.	Hydrogen	48-56	C-C motif chemokine ligand 28	Homo sapiens	18-21
18794298-5	2008	Using hydrogen/deuterium exchange and mass spectrometry, we have obtained molecular level structural information on the alpha(1)-antitrypsin polymer.	Hydrogen	6-14	serpin family A member 1	Homo sapiens	120-140
18995838-3	2008	This structure, which was solved at a resolution of 1.15 A, reveals specific recognition of the peptide alpha-amino group via hydrogen bonding and shows that the peptide"s N-terminal tyrosine side chain is buried in a deep hydrophobic cleft that pre-exists on the surface of ClpS.	Hydrogen	126-134	colipase	Homo sapiens	275-279
18768235-7	2008	Fasting, 1h and 3h post-load glucose levels were significantly elevated in patients who required insulin.	Hydrogen	9-11	insulin	Homo sapiens	97-104
18926701-5	2008	Furthermore, it was demonstrated that hydrogen-bonding properties were significant with respect to Pgp interactions.	Hydrogen	38-46	ATP binding cassette subfamily B member 1	Homo sapiens	99-102
18641079-3	2008	This finding is demonstrated by increases in the root mean-square deviations of the heavy atoms of lysozyme, in the solvent-accessible surface area of hydrophobic residues, and in the number of hydrogen bonds between lysozyme and water.	Hydrogen	194-202	lysozyme	Homo sapiens	217-225
18641079-4	2008	The solvent-accessible surface area of hydrophilic residues changes marginally, and the number of hydrogen bonds between lysozyme molecules decreases.	Hydrogen	98-106	lysozyme	Homo sapiens	121-129
19012568-5	2008	By [15N-1H] HSQC NMR studies we revealed that c-VIAF binds to the RING domain of XIAP and characterized the important residues involved in the binding.	Hydrogen	8-10	phosducin like 3	Homo sapiens	46-52
19031908-3	2008	Here we report an MEC-MFC-coupled system for biohydrogen production from acetate, in which hydrogen was produced in an MEC and the extra power was supplied by an MFC.	Hydrogen	48-56	C-C motif chemokine ligand 28	Homo sapiens	119-122
18723411-2	2008	The results indicate that chiral recognition on the alpha3beta4 nAChR is a process involving initial tethering of dextromethorphan and levomethorphan at hydrophobic pockets within the central lumen followed by hydrogen bonding interactions favoring dextromethorphan.	Hydrogen	210-218	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	64-69
19098380-8	2008	The increase in angiotensin II type 1 receptor (AT(1)R) expression and the increase in reduced nicotinamide-adenine dinucleotide phosphate (NAD(P)H) oxidase activity in the RVLM were significantly greater in HS-S than in RS-S.	Hydrogen	208-212	angiotensin II receptor, type 1b	Rattus norvegicus	16-46
19098380-8	2008	The increase in angiotensin II type 1 receptor (AT(1)R) expression and the increase in reduced nicotinamide-adenine dinucleotide phosphate (NAD(P)H) oxidase activity in the RVLM were significantly greater in HS-S than in RS-S.	Hydrogen	208-212	angiotensin II receptor, type 1b	Rattus norvegicus	48-54
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Hydrogen	271-279	membrane metalloendopeptidase	Homo sapiens	398-401
18986818-3	2008	Key hydrogen bonding interactions between mometasone furoate and the glucocorticoid receptor, as well as favorable hydrophobic interactions between the furoate group and the 17alpha pocket, contribute to high affinity and specificity of this ligand for the receptor.	Hydrogen	4-12	nuclear receptor subfamily 3 group C member 1	Homo sapiens	69-92
18771696-8	2008	In addition, there was an increase in the mRNAs of five of the seven genes (Fos, Cyr61, Btg2, Adamts1, and Gem) in the neocortex of mice exposed to the stress for 1h.	Hydrogen	163-165	cellular communication network factor 1	Mus musculus	81-86
18640987-8	2008	Based upon the Kv1.2 crystal structure, further mutagenesis, and the partial restoration of surface expression in an electrostatic T330K bridging mutant, we suggest that Thr-330 hydrogen bonds to equally conserved outer pore residues, which may include a glutamate at position 502 that is also critical for surface expression.	Hydrogen	178-186	potassium voltage-gated channel subfamily A member 2	Homo sapiens	15-20
18771696-8	2008	In addition, there was an increase in the mRNAs of five of the seven genes (Fos, Cyr61, Btg2, Adamts1, and Gem) in the neocortex of mice exposed to the stress for 1h.	Hydrogen	163-165	BTG anti-proliferation factor 2	Mus musculus	88-92
18771696-8	2008	In addition, there was an increase in the mRNAs of five of the seven genes (Fos, Cyr61, Btg2, Adamts1, and Gem) in the neocortex of mice exposed to the stress for 1h.	Hydrogen	163-165	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	Mus musculus	94-101
18627523-5	2008	Instead it is proposed that an association complex between excited state [IrCl(CO)(PPh3)2] and CHCl3 leads to dissociation of a chlorine atom from CHCl3, yielding HCl after abstraction of a hydrogen from another CHCl3.	Hydrogen	190-198	caveolin 1	Homo sapiens	83-87
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Hydrogen	271-279	membrane metalloendopeptidase	Homo sapiens	403-430
18788725-6	2008	High lipophilicity and a positive net charge were found to be the key physicochemical properties for OCT1 inhibition, whereas a high molecular dipole moment and many hydrogen bonds were negatively correlated to OCT1 inhibition.	Hydrogen	166-174	solute carrier family 22 member 1	Homo sapiens	211-215
18798649-2	2008	POR catalyzes the trans addition of hydrogen across the C17-C18 double bond of protochlorophyllide (Pchlide), which is a key step in chlorophyll biosynthesis.	Hydrogen	36-44	cytochrome p450 oxidoreductase	Homo sapiens	0-3
18940604-5	2008	The Rab27B/Slac2-a complex exhibits several intermolecular hydrogen bonds that were not observed in the previously reported Rab3A/rabphilin complex.	Hydrogen	59-67	melanophilin	Homo sapiens	11-18
18940604-6	2008	A Rab27A mutation that disrupts one of the specific hydrogen bonds with Slac2-a resulted in the dramatic reduction of Slac2-a binding activity.	Hydrogen	52-60	melanophilin	Homo sapiens	72-79
18940604-6	2008	A Rab27A mutation that disrupts one of the specific hydrogen bonds with Slac2-a resulted in the dramatic reduction of Slac2-a binding activity.	Hydrogen	52-60	melanophilin	Homo sapiens	118-125
18790640-3	2008	Installing a hydroxyl group on the benzene ring of the core has the potential to form a key hydrogen bond interaction to the hinge region of the binding pocket and thus resulted in the most potent inhibitor, 19, with K(i) values at 2.5 and 43.5 nM against Pim-1 and Pim-2, respectively.	Hydrogen	92-100	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	256-261
18650427-7	2008	Using LC8 point mutants K36P and T67A, we were able to differentiate Pak1 from canonical LC8 binding sequences and identify a key hydrogen bond network that compensates for the loss of the conserved glutamine in the consensus sequence.	Hydrogen	130-138	dynein light chain LC8-type 1	Homo sapiens	6-9
18573309-9	2008	This is due to ten hydrogen bonds and eight salt bridges which exist between the native type and cdk6, whereas the mutant type makes only nine hydrogen bonds and five salt bridges with cdk6.	Hydrogen	19-27	cyclin dependent kinase 6	Homo sapiens	97-101
18540588-3	2008	By probing the neutral hydrogen following UV excitation, we show that hydrogen elimination along the dissociative pi sigma* potential energy surface occurs within 103 +/- 30 fs, indicating efficient coupling at the S1/S2 and S0/S2 conical intersections, with no identifiable role of statistical unimolecular decay of vibronically excited (S0) phenol in the timeframe of our measurements.	Hydrogen	23-31	proteasome 26S subunit, non-ATPase 1	Homo sapiens	215-220
18540588-3	2008	By probing the neutral hydrogen following UV excitation, we show that hydrogen elimination along the dissociative pi sigma* potential energy surface occurs within 103 +/- 30 fs, indicating efficient coupling at the S1/S2 and S0/S2 conical intersections, with no identifiable role of statistical unimolecular decay of vibronically excited (S0) phenol in the timeframe of our measurements.	Hydrogen	70-78	proteasome 26S subunit, non-ATPase 1	Homo sapiens	215-220
18727697-7	2008	The transplant induced upregulation in the inflammatory mediators CCL2, IL-1 beta, IL-6 and TNF-alpha were mitigated by hydrogen.	Hydrogen	120-128	interleukin 6	Homo sapiens	83-87
18727697-7	2008	The transplant induced upregulation in the inflammatory mediators CCL2, IL-1 beta, IL-6 and TNF-alpha were mitigated by hydrogen.	Hydrogen	120-128	tumor necrosis factor	Homo sapiens	92-101
18589009-11	2008	In normal growth medium, addition of PI-88 reduced migration of ATDC-5 cells, suggesting that HPSE facilitates cartilage replacement by bone at the chondro-osseous junction by removing the HS component of proteoglycans, such as perlecan/HSPG2, that otherwise prevent osteogenic cells from remodeling hypertrophic cartilage.	Hydrogen	189-191	heparanase	Mus musculus	94-98
18799315-7	2008	We conclude that the mechanism of the MAO-B-catalyzed oxidation of pyrrolinyl substrates is similar to that of the tetrahydropyridinyl substrates and that a carbon-hydrogen bond cleavage step is, at least partially, rate determining.	Hydrogen	164-172	monoamine oxidase B	Bos taurus	38-43
18714953-4	2008	The barrier for reaction 1 in which NSCl decomposes to form HNSO becomes substantially lower when the explicit hydrogen bonding of water molecules is considered.	Hydrogen	111-119	nescient helix-loop-helix 1	Homo sapiens	36-40
18729328-14	2008	This alteration appears to be enforced by an extended hydrogen-bonding network between residues on the glutathione moiety attached to Cys434 and amino acid side chains that have been shown to be essential for repression of Nrf2 by Keap1.	Hydrogen	54-62	NFE2 like bZIP transcription factor 2	Homo sapiens	223-227
18729328-14	2008	This alteration appears to be enforced by an extended hydrogen-bonding network between residues on the glutathione moiety attached to Cys434 and amino acid side chains that have been shown to be essential for repression of Nrf2 by Keap1.	Hydrogen	54-62	kelch like ECH associated protein 1	Homo sapiens	231-236
18766096-16	2008	An inverse relationship was found between hydrogen ion concentration and concentrations of tumor necrosis factor-alpha and interleukin-10.	Hydrogen	42-50	tumor necrosis factor	Homo sapiens	91-118
18409193-1	2008	The self-association of human growth hormone(hGH) was investigated using 15N NMR relaxation.The investigation relies on the 15N R1 and R2 relaxation rates and the heteronuclear{1H}-15N NOEs of the backbone amide groups at multiple protein concentrations.	Hydrogen	177-179	growth hormone 1	Homo sapiens	30-49
18754612-8	2008	Docking simulations identified several hydrogen bonds lost upon truncation that provide an explanation for the reduced affinities observed at the alpha7 nAChR and AChBP.	Hydrogen	39-47	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	153-158
18707846-11	2008	The levels of TNF-alpha, IL-6, F1+2 and D-dimer significantly decreased 1h after infliximab infusion (P=0.005).	Hydrogen	72-74	tumor necrosis factor	Homo sapiens	14-23
18768317-3	2008	The catechol compound docked to the Stat3 SH2 domain in computer modeling forms hydrogen bonds with the conserved pTyr-interacting amino acids.	Hydrogen	80-88	signal transducer and activator of transcription 3	Homo sapiens	36-41
18666782-13	2008	The b 2 portion of neurotensin (9-13) has 6 exchangeable hydrogens, whereas the +1 charge state of neurotensin (9-13) has 12 exchangeable hydrogens.	Hydrogen	57-66	neurotensin	Homo sapiens	19-30
18666782-13	2008	The b 2 portion of neurotensin (9-13) has 6 exchangeable hydrogens, whereas the +1 charge state of neurotensin (9-13) has 12 exchangeable hydrogens.	Hydrogen	138-147	neurotensin	Homo sapiens	99-110
18707846-11	2008	The levels of TNF-alpha, IL-6, F1+2 and D-dimer significantly decreased 1h after infliximab infusion (P=0.005).	Hydrogen	72-74	interleukin 6	Homo sapiens	25-29
18794787-5	2008	The hydrophobic features were confirmed to contribute significantly to inhibitor potencies, while a pre-oriented hydrogen bond provided by the hydroxyl group at the 3-position indicated a good correlation with previous SAR, and a hydrogen bond acceptor may play a crucial role in CETP inhibition.	Hydrogen	113-121	cholesteryl ester transfer protein	Homo sapiens	280-284
18579710-3	2008	A recent novel pharmacophore for PXR antagonists was developed using three azoles and consisted of two hydrogen bond acceptor regions and two hydrophobic features.	Hydrogen	103-111	nuclear receptor subfamily 1 group I member 2	Homo sapiens	33-36
18794787-5	2008	The hydrophobic features were confirmed to contribute significantly to inhibitor potencies, while a pre-oriented hydrogen bond provided by the hydroxyl group at the 3-position indicated a good correlation with previous SAR, and a hydrogen bond acceptor may play a crucial role in CETP inhibition.	Hydrogen	230-238	cholesteryl ester transfer protein	Homo sapiens	280-284
18636743-1	2008	Structural analysis of human MRP1-NBD1 revealed that the Walker A S685 forms a hydrogen bond with the Walker B D792 and interacts with the Mg (2+) cofactor and the beta-phosphate of the bound Mg.ATP.	Hydrogen	79-87	ATP binding cassette subfamily C member 1	Homo sapiens	29-38
18300229-7	2008	In particular, the functionally critical C-D and G-H loops of the ephrin-B2 ectodomain are highly flexible as reflected by several NMR probes including hydrogen exchange and (15)N backbone relaxation data.	Hydrogen	152-160	ephrin B2	Homo sapiens	66-75
18648699-6	2008	For these complexes all calculations are in relatively good agreement compared to experimental data with errors not exceeding 20% except for the hydrogen atom in Ru(H)2(dppm)(PPh3)2.	Hydrogen	145-153	caveolin 1	Homo sapiens	175-179
18351682-3	2008	In this study, hydrogen-deuterium exchange (HX) detected by mass spectrometry (MS) was used to measure Abeta(1-40) aggregate distributions without purification or modification that might alter the aggregate structure or distribution.	Hydrogen	15-23	amyloid beta precursor protein	Homo sapiens	103-108
18637681-2	2008	The docking results indicate that residues TYR48, HIS110, and TRP111 construct the active pocket of ALR2 and, besides van der Waals and hydrophobic interaction, CM mainly interact with ALR2 by forming hydrogen bonds to cause inhibitory behavior.	Hydrogen	201-209	aldo-keto reductase family 1 member B	Homo sapiens	100-104
18611014-0	2008	Complexes of borane and N-heterocyclic carbenes: a new class of radical hydrogen atom donor.	Hydrogen	72-80	high mobility group nucleosomal binding domain 4	Homo sapiens	24-47
18637681-2	2008	The docking results indicate that residues TYR48, HIS110, and TRP111 construct the active pocket of ALR2 and, besides van der Waals and hydrophobic interaction, CM mainly interact with ALR2 by forming hydrogen bonds to cause inhibitory behavior.	Hydrogen	201-209	aldo-keto reductase family 1 member B	Homo sapiens	185-189
18611014-3	2008	The resulting prediction that NHC borane complexes could be used as radical hydrogen atom donors was verified by radical deoxygenations of xanthates by using either AIBN or triethylborane as initiator.	Hydrogen	76-84	high mobility group nucleosomal binding domain 4	Homo sapiens	30-33
18456822-0	2008	Sequence-specific conformational flexibility of SNARE transmembrane helices probed by hydrogen/deuterium exchange.	Hydrogen	86-94	small NF90 (ILF3) associated RNA E	Homo sapiens	48-53
18578491-5	2008	The ability of these assemblies to capture cations, such as Na(+) in [Pt3Na(3-NC5H4CO2)3(OTf)3(PPh3)6](+) through hydrogen bonding or Ag(+) in [PdAg(2-NC5H4CO2)(OTf)2(dppf)] through dative bonding, is described and compared.	Hydrogen	114-122	caveolin 1	Homo sapiens	95-99
26631704-6	2008	In addition, according to the experimentally detected enhancement of the reaction rate due to the presence of a nitro group on the benzoate ligand, our calculations show that the transition state for the hydrogen atom abstraction by molecular oxygen along the pathway for the oxygenation reaction of (IMe)2(p-O2NC6H4CO2)PdH lies lower in energy with respect to the analogous transition state calculated for R=Ph.	Hydrogen	204-212	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	320-323
18262646-8	2008	1h after irradiation by the lethal doses 5 and 10 Gy we detected by Western blot a decrease in repair proteins Mre11, Rad50, and Nbs1.	Hydrogen	0-2	MRE11 homolog, double strand break repair nuclease	Homo sapiens	111-116
18579376-2	2008	As an alternative chemical template, a novel series of alkoxybenzamides were developed with restricted conformation through intramolecular hydrogen bond formation; the compounds exhibit low nM enzyme and cellular activity as PARP-1 inhibitors.	Hydrogen	139-147	poly(ADP-ribose) polymerase 1	Homo sapiens	225-231
18572937-9	2008	These results suggest a combination of water-mediated hydrogen bonding and headgroup repulsion in determining the organization of PIP 2, and may contribute to an explanation for the unique functionality of PIP 2 compared to other anionic phospholipids.	Hydrogen	54-62	prolactin induced protein	Homo sapiens	130-133
18572937-9	2008	These results suggest a combination of water-mediated hydrogen bonding and headgroup repulsion in determining the organization of PIP 2, and may contribute to an explanation for the unique functionality of PIP 2 compared to other anionic phospholipids.	Hydrogen	54-62	prolactin induced protein	Homo sapiens	206-209
18591792-4	2008	The studies show (R=0.945, RMSD=2.186, Deltacost=677.354) the importance of hydrogen bond acceptors in the aromatic rings and a planner hydrophobic region in the molecular architecture along with critical geometrical distance between features are effectively crucial for binding with ER.	Hydrogen	76-84	estrogen receptor 1	Homo sapiens	284-286
18467331-3	2008	The binding of PRL variants to the PRLR extracellular domain was furthermore characterized by the solution state techniques, hydrogen exchange mass spectrometry, and NMR spectroscopy.	Hydrogen	125-133	prolactin	Homo sapiens	15-18
18599981-1	2008	Molecules of the title compound, C(12)H(13)ClN(4), are linked by two independent N-H...N hydrogen bonds into a chain of edge-fused R(2)(2)(8) rings.	Hydrogen	89-97	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	43-48
18540595-8	2008	As for protonation of the hydrogen cluster, it turned out that mu-H species are always more stable than terminal hydride isomers, leading to the conclusion that specific interactions of the H-cluster with the environment, not considered in our calculations, would be necessary to reverse the stability order of mu-H and terminal hydrides.	Hydrogen	26-34	familial progressive hyperpigmentation 1	Homo sapiens	63-67
18540595-8	2008	As for protonation of the hydrogen cluster, it turned out that mu-H species are always more stable than terminal hydride isomers, leading to the conclusion that specific interactions of the H-cluster with the environment, not considered in our calculations, would be necessary to reverse the stability order of mu-H and terminal hydrides.	Hydrogen	26-34	familial progressive hyperpigmentation 1	Homo sapiens	311-315
18528972-1	2008	We study the hydrogen tunneling problem in a model system that represents the active site of the biological enzyme, soybean lipoxygenase-1.	Hydrogen	13-21	seed linoleate 13S-lipoxygenase-1	Glycine max	124-138
18023931-4	2008	QSAR model derived from Hansch analysis demonstrated that COX-2 inhibitory activity is correlated with sum of atomic polarizability (Apol), number of hydrogen-bond donor groups (HBD), energy of the highest occupied molecular orbital (HOMO), desolvation free energy for water (F(H(2)O)) and fraction of areas of molecular shadow in the XY and ZX planes over area of enclosing rectangle (Sxyf and Sxzf) with r ranges 0.870-0.904.	Hydrogen	150-158	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-63
18490897-8	2008	Our results reveal that ethanol-induced rearrangement of the conformation of fixed RNase A leads to protein aggregation through the formation of large geometrically compatible hydrophobic beta-sheets that are likely stabilized by formaldehyde cross-links, hydrogen bonds, and van der Waals interactions.	Hydrogen	256-264	ribonuclease pancreatic	Bos taurus	83-90
18459103-0	2008	Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.	Hydrogen	85-87	tumor necrosis factor receptor superfamily, member 25	Mus musculus	23-66
18459103-0	2008	Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.	Hydrogen	85-87	tumor necrosis factor receptor superfamily, member 25	Mus musculus	68-73
18611337-13	2008	However, intense positive immunostaining for TGF-beta1 was observed in alveolar epithelial cells, pulmonary interstitial inflammatory cell as well as macrophage cells of alveolar space of the HS group.	Hydrogen	192-194	transforming growth factor, beta 1	Rattus norvegicus	45-54
18501927-0	2008	Hydrogen-exchange mass spectrometry reveals activation-induced changes in the conformational mobility of p38alpha MAP kinase.	Hydrogen	0-8	mitogen-activated protein kinase 1	Homo sapiens	105-108
18501927-2	2008	Here, we examine p38alpha MAP kinase (MAPK) by hydrogen-exchange (HX) mass spectrometry to determine whether changes in conformational mobility may be induced by kinase phosphorylation and activation.	Hydrogen	47-55	mitogen-activated protein kinase 14	Homo sapiens	17-25
18485899-3	2008	Hydrogen exchange rates of the imino protons were measured for free Macugen and Macugen bound to the HBD or full-length VEGF to better understand the mechanism for high affinity binding.	Hydrogen	0-8	vascular endothelial growth factor A	Homo sapiens	120-124
18346844-6	2008	Western blot analysis demonstrated that 5 microM imatinib treatment for 1h activated the MEK-MAPK pathway and the activation was independent of Ras activation.	Hydrogen	72-74	mitogen-activated protein kinase kinase 7	Homo sapiens	89-92
18465862-1	2008	The relation between the hydrogen atom transfer (HAT) and proton-coupled electron transfer (PCET) mechanisms is discussed and is illustrated by multiconfigurational electronic structure calculations on the ArOH + R(*) --&gt; ArO(*) + RH reactions.	Hydrogen	25-33	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	206-209
18395518-6	2008	These results suggested that hydrogen-bonding as well as hydrophobic interactions with sugar groups of glycolipids drive the membrane binding of Abeta-(1-40).	Hydrogen	29-37	amyloid beta precursor protein	Homo sapiens	145-150
18462753-7	2008	These data show that cofactor selectivity is governed by a complex network of hydrogen bonds between the oxygen atoms of the 2"-phosphoryl moiety of NADP(+) and a threonine/lysine pair on ALDH(C).	Hydrogen	78-86	aldehyde dehydrogenase family protein	Paraburkholderia xenovorans LB400	188-192
18438983-7	2008	The 1H NMR study also shows that progressive addition of PdCl2 or [PdCl2(NCR)2] (R=Me or Ph) to DMSO-d6 solutions of 1 reversibly leads to the formation of 4 and the addition of excess PdII is necessary to lead to the complete disappearance of the signals of 1.	Hydrogen	4-6	natural cytotoxicity triggering receptor 2	Homo sapiens	73-78
17825954-5	2008	The binding mode of the compounds at the active site of p38 MAP alpha kinase was explored using Glide docking program and hydrogen-bonding interactions were observed between the inhibitors and the target.	Hydrogen	122-130	mitogen-activated protein kinase 14	Homo sapiens	56-59
19636924-0	2008	1H, 13C, and 15N chemical shift assignments for the Eps15-EH2-stonin 2 complex.	Hydrogen	0-2	epidermal growth factor receptor pathway substrate 15	Homo sapiens	52-57
19636926-0	2008	1H, 15N, and 13C chemical shift assignments of calcium-bound calcium-binding protein 1 (CaBP1).	Hydrogen	0-2	calcium binding protein 1	Homo sapiens	61-86
19636926-0	2008	1H, 15N, and 13C chemical shift assignments of calcium-bound calcium-binding protein 1 (CaBP1).	Hydrogen	0-2	calcium binding protein 1	Homo sapiens	88-93
19636929-0	2008	1H, 13C, and 15N resonance assignments of human zeta-COP.	Hydrogen	0-2	COPI coat complex subunit zeta 1	Homo sapiens	48-56
18295464-8	2008	The peak plasma insulin level (Cmax) of medium crosslinked EE-L2-NPs (258 muIU/ml at 1h) vindicates the pharmacodynamic effect, which was found to be superior compared to all other formulations.	Hydrogen	85-87	insulin	Homo sapiens	16-23
18500801-4	2008	These data showed unequivocally that Ltb4dh mediated net trans-addition of hydrogen to (R)-perillaldehyde but followed the opposite stereochemical course (net syn-addition) for (S)-perillaldehyde.	Hydrogen	75-83	prostaglandin reductase 1	Rattus norvegicus	37-43
18492610-4	2008	Our induced-fit docking studies suggested that 5-(4-hydroxybenzylidene)-substituted derivatives may bind the polar recognition region of the ALR2 active site by means of the deprotonated phenol group, while their acetic chain and carbonyl group at position 2 of the thiazolidinedione ring form a tight net of hydrogen bonds with amino acid residues of the lipophilic specificity pocket of the enzyme.	Hydrogen	309-317	aldo-keto reductase family 1 member B	Homo sapiens	141-145
18510993-7	2008	We found that herceptin has a high binding affinity with mutant HER2 receptor, with a binding energy of -24.40 kcal/mol, as compared to the native type, which has a binding energy of -15.26 kcal/mol due to six-hydrogen bonding and two salt bridges exist between herceptin and the mutant type, whereas the native type establishes four hydrogen bonds and two salt bridges with herceptin.	Hydrogen	210-218	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
18510993-7	2008	We found that herceptin has a high binding affinity with mutant HER2 receptor, with a binding energy of -24.40 kcal/mol, as compared to the native type, which has a binding energy of -15.26 kcal/mol due to six-hydrogen bonding and two salt bridges exist between herceptin and the mutant type, whereas the native type establishes four hydrogen bonds and two salt bridges with herceptin.	Hydrogen	334-342	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
18510993-9	2008	Normal mode analysis also showed that the two amino acids, namely Asp596 and Glu598 of mutant HER2, forming additional hydrogen bonding with herceptin, had a slightly higher flexibility than the native type.	Hydrogen	119-127	erb-b2 receptor tyrosine kinase 2	Homo sapiens	94-98
17892922-10	2008	Postoperative levels of AST and LDH correlated significantly with the ablated liver volume 1h after RFA (RC = 0.860 and RC = 0.868, respectively, p &lt; 0.05).	Hydrogen	91-93	solute carrier family 17 member 5	Homo sapiens	24-27
26621242-7	2008	Hydrogen bonding interactions were observed between the atRA carboxylate group and Arg 90 in CYP26A1 and with Arg76, Arg95, and Ser369 in CYP26B1.	Hydrogen	0-8	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	93-100
26621242-7	2008	Hydrogen bonding interactions were observed between the atRA carboxylate group and Arg 90 in CYP26A1 and with Arg76, Arg95, and Ser369 in CYP26B1.	Hydrogen	0-8	cytochrome P450 family 26 subfamily B member 1	Homo sapiens	138-145
17950494-5	2008	The central part of the inhibitor binds in an improved melagatran-like mode, while the structure identifies a d-tyrosine as P1 residue which forms a charged hydrogen bond with Asp 189 of thrombin.	Hydrogen	157-165	coagulation factor II, thrombin	Homo sapiens	187-195
17950494-6	2008	This is the first crystal structure of a thrombin-inhibitor complex, where an uncharged inhibitor residue makes hydrogen bonds within the thrombin S1 pocket.	Hydrogen	112-120	coagulation factor II, thrombin	Homo sapiens	41-49
17950494-6	2008	This is the first crystal structure of a thrombin-inhibitor complex, where an uncharged inhibitor residue makes hydrogen bonds within the thrombin S1 pocket.	Hydrogen	112-120	coagulation factor II, thrombin	Homo sapiens	138-146
17950494-7	2008	Additionally, novel favourable intermolecular hydrogen bonds of the inhibitor with the thrombin backbone become possible due to the d-configuration of the P1 residue.	Hydrogen	46-54	coagulation factor II, thrombin	Homo sapiens	87-95
18474858-2	2008	We describe an approach to classify estrogen receptor (ER) modulators based on dynamics of the receptor-ligand complex as probed with hydrogen/deuterium exchange (HDX) mass spectrometry.	Hydrogen	134-142	estrogen receptor 1	Homo sapiens	36-53
18265412-8	2008	Moreover, myricetin directly interacted with the active site of caspase-3 via three hydrogen bonds and inhibited its activity.	Hydrogen	84-92	caspase 3	Homo sapiens	64-73
18474858-2	2008	We describe an approach to classify estrogen receptor (ER) modulators based on dynamics of the receptor-ligand complex as probed with hydrogen/deuterium exchange (HDX) mass spectrometry.	Hydrogen	134-142	estrogen receptor 1	Homo sapiens	55-57
18346713-6	2008	The structure-activity analysis suggests that a small hydrophobic pocket and the H-loop of PDE5 are important for the inhibitor affinity, in addition to two common elements for binding of almost all the PDE inhibitors: the stack against the phenylalanine and the hydrogen bond with the invariant glutamine.	Hydrogen	263-271	phosphodiesterase 5A	Homo sapiens	91-95
18339304-5	2008	PFF (0.7+/-0.3Pa, 5Hz, 1h) upregulated Bcl-2 and downregulated caspase-3 expression in osteocytes.	Hydrogen	23-25	BCL2 apoptosis regulator	Homo sapiens	39-44
18339304-5	2008	PFF (0.7+/-0.3Pa, 5Hz, 1h) upregulated Bcl-2 and downregulated caspase-3 expression in osteocytes.	Hydrogen	23-25	caspase 3	Homo sapiens	63-72
18396880-4	2008	The solid coinage-metal monohydrides, CuH(s), AgH(s), and AuH(s), are predicted to be unstable with respect to the formation from the metals and elemental hydrogen by an approximately constant standard enthalpy of formation, Delta(f)H(o)(s) approximately +80 +/- 20 kJ mol(-1).	Hydrogen	155-163	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	58-61
18199660-0	2008	The kinetics of the hydrogen/deuterium exchange of epidermal growth factor receptor ligands.	Hydrogen	20-28	epidermal growth factor receptor	Homo sapiens	51-83
18199660-1	2008	Five highly homologous epidermal growth factor receptor ligands were studied by mass spectral analysis, hydrogen/deuterium (H/D) exchange via attenuated total reflectance Fourier transform-infrared spectroscopy, and two-dimensional correlation analysis.	Hydrogen	104-112	epidermal growth factor receptor	Homo sapiens	23-55
18508610-4	2008	In the Abeta(25-35) peptide, which is weakly hydrophobic, the tendency to form hydrogen bonds drives the crossing of a single major free energy barrier for the formation of a cross-beta structure.	Hydrogen	79-87	amyloid beta precursor protein	Homo sapiens	7-12
18522125-2	2008	It has been assumed that a membrane is needed in an MEC to avoid hydrogen losses due to bacterial consumption of the product gas.	Hydrogen	65-73	C-C motif chemokine ligand 28	Homo sapiens	52-55
18522125-3	2008	However, high cathodic hydrogen recoveries (78 +/- 1% to 96 +/- 1%) were achieved in an MEC despite the absence of a membrane between the electrodes (applied voltages of 0.3 &lt; E(ap) &lt; 0.8 V; 7.5 mS/cm solution conductivity).	Hydrogen	23-31	C-C motif chemokine ligand 28	Homo sapiens	88-91
18522125-4	2008	Through the use of a membrane-less system, a graphite fiber brush anode, and close electrode spacing, hydrogen production rates reached a maximum of 3.12 +/- 0.02 m3 H2/m3 reactor per day (292 +/- 1 A/m3) at an applied voltage of E(ap) = 0.8 V. This production rate is more than double that obtained in previous MEC studies.	Hydrogen	102-110	C-C motif chemokine ligand 28	Homo sapiens	312-315
18522125-4	2008	Through the use of a membrane-less system, a graphite fiber brush anode, and close electrode spacing, hydrogen production rates reached a maximum of 3.12 +/- 0.02 m3 H2/m3 reactor per day (292 +/- 1 A/m3) at an applied voltage of E(ap) = 0.8 V. This production rate is more than double that obtained in previous MEC studies.	Hydrogen	166-168	C-C motif chemokine ligand 28	Homo sapiens	312-315
18327926-6	2008	Up to five solvent H2O molecules can stay around solute NO3(-) anion in structures having an inter-water hydrogen-bonded cyclic network.	Hydrogen	105-113	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
18351302-5	2008	The negative entropy change and enthalpy change indicated that the interaction of TRES and BSA was driven mainly by van der Waals interactions and hydrogen bonds.	Hydrogen	147-155	albumin	Homo sapiens	91-94
18363407-5	2008	For sp3 to sp2 rehybridization, the quasiclassical alpha-secondary KIE shows an unusual inverse effect due to compression of the nonbonding hydrogens in the suprafacial transition state.	Hydrogen	140-149	Sp3 transcription factor	Homo sapiens	4-7
18363407-5	2008	For sp3 to sp2 rehybridization, the quasiclassical alpha-secondary KIE shows an unusual inverse effect due to compression of the nonbonding hydrogens in the suprafacial transition state.	Hydrogen	140-149	Sp2 transcription factor	Homo sapiens	11-14
18327921-10	2008	This combination of modern hardware and efficient NMR sequences provides a unique tool to analyze the (2H/1H)i ratios of large prochiral molecules (C-18) dissolved in organic solutions of poly(gamma-benzyl-L-glutamate) and requires smaller amounts of solute than previous study on fatty acids.	Hydrogen	106-108	Bardet-Biedl syndrome 9	Homo sapiens	148-152
18333607-5	2008	The strong hydrogen bonding between the amide NH of taranabant and hydroxyl of S(7.39)383 was key to the superior affinity of taranabant to CB1R.	Hydrogen	11-19	cannabinoid receptor 1	Homo sapiens	140-144
18256274-7	2008	ANG II markedly increased in vitro transcription of mRNAs for transforming growth factor-beta1 by 143% (P &lt; 0.01), macrophage chemoattractant protein-1 by 89% (P &lt; 0.01), and the sodium and hydrogen exchanger-3 by 110% (P &lt; 0.01).	Hydrogen	196-204	angiotensinogen	Rattus norvegicus	0-6
18275142-6	2008	Delta-1 and Lambda-1 belong to supramolecular stereoisomers, which are constructed via hydrogen bond linking of [Ni( f-SS-L)(l-Phe)](+) and [Ni(f-RR-L)(d-Phe)](+) monomers to form 1D homochiral right-handed and left-handed helical chains, respectively.	Hydrogen	87-95	delta like non-canonical Notch ligand 1	Homo sapiens	0-7
18339314-3	2008	This study is focused on structural characterization of these C18 monoepoxy FAMEs using techniques in NMR spectroscopy including 1H, 13C, 1H-1H correlated spectroscopy (COSY) and 1H-13C heteronuclear correlation (HETCOR).	Hydrogen	129-131	Bardet-Biedl syndrome 9	Homo sapiens	62-65
18289863-3	2008	X-ray crystallography discloses that the nitro group well mimics the transition state occurred in the hydrolysis catalyzed by CPA, that is, an O,O"-bidentate coordination to the zinc ion and the two respective hydrogen bonds with Glu-270 and Arg-127.	Hydrogen	210-218	carboxypeptidase A1	Homo sapiens	126-129
18236493-5	2008	Docking of representative compounds into a homology model of human aromatase assists in the rationalisation of the SAR derived from the in vitro biological results and supports a crucial role for a cyano group on the "A" phenyl ring, which is accessible to hydrogen bond interactions with Ser 478.	Hydrogen	257-265	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	67-76
18272371-4	2008	Molecular modeling and comparison of molecular models of 5a enantiomers with that of celecoxib model shows that 5a (enantiomer-1) and 5a (enantiomer-2) have more hydrogen bonding interactions in the catalytic domain of COX-2 enzyme than celecoxib.	Hydrogen	162-170	prostaglandin-endoperoxide synthase 2	Homo sapiens	219-224
18332863-0	2008	Sodium/hydrogen exchange inhibition with cariporide reduces leukocyte adhesion via P-selectin suppression during inflammation.	Hydrogen	7-15	selectin P	Rattus norvegicus	83-93
18339314-3	2008	This study is focused on structural characterization of these C18 monoepoxy FAMEs using techniques in NMR spectroscopy including 1H, 13C, 1H-1H correlated spectroscopy (COSY) and 1H-13C heteronuclear correlation (HETCOR).	Hydrogen	138-140	Bardet-Biedl syndrome 9	Homo sapiens	62-65
18339314-3	2008	This study is focused on structural characterization of these C18 monoepoxy FAMEs using techniques in NMR spectroscopy including 1H, 13C, 1H-1H correlated spectroscopy (COSY) and 1H-13C heteronuclear correlation (HETCOR).	Hydrogen	138-140	Bardet-Biedl syndrome 9	Homo sapiens	62-65
18339314-3	2008	This study is focused on structural characterization of these C18 monoepoxy FAMEs using techniques in NMR spectroscopy including 1H, 13C, 1H-1H correlated spectroscopy (COSY) and 1H-13C heteronuclear correlation (HETCOR).	Hydrogen	138-140	Bardet-Biedl syndrome 9	Homo sapiens	62-65
18404574-2	2008	Although all synthesized compounds were totally devoid of binding affinity at the human A3AR, our results revealed that 3"-position of adenosine can only be tolerated with small size of a hydrogen bonding donor like hydroxyl or amino group in the binding site of human A3AR.	Hydrogen	188-196	adenosine A3 receptor	Homo sapiens	269-273
18343905-8	2008	The results indicated that substitution of halogen and methyl groups by hydrogen at aromatic ring of the benzothiazepine decreased the affinity of these molecules towards enzyme that may be due to the polar non-polar repulsions of these moieties with the amino acid residues in the active site of AChE.	Hydrogen	72-80	acetylcholinesterase (Cartwright blood group)	Homo sapiens	297-301
18192540-9	2008	The R46Q substitution changes an invariant arginine residue in position B22, which forms a hydrogen bond with the glutamate at A17, stabilizing the insulin molecule.	Hydrogen	91-99	insulin	Homo sapiens	148-155
18267129-4	2008	This was concomitant with a decreased cytosolic glutathione peroxidase (GPx1) activity, a crucial enzyme for protection against hydrogen and lipid peroxides, while major antioxidant enzyme activities increased in both cell lines in response to ROS.	Hydrogen	128-136	glutathione peroxidase 1	Rattus norvegicus	72-76
18255292-2	2008	From this study, it was revealed that removal of the hydrogen bond-donating ability of the 5"-uronamide was essential for the pure A(3)AR antagonism.	Hydrogen	53-61	adenosine A3 receptor	Homo sapiens	131-137
18174163-10	2008	In contrast, hydrogen bond donors (e.g. amides, alcohols) diminish binding to mOat6.	Hydrogen	13-21	solute carrier family 22 (organic anion transporter), member 20	Mus musculus	78-83
18177671-6	2008	Compaction of at least one alpha-helix along its axis mediated by internal hydrogen bonds and stabilized by diffuse tertiary structure interactions appears to be one important molecular event during early folding in barstar, CI2, spectrin R16 domain, Arc repressor, alpha-lactalbumin, IM7, IM9, and spectrin R17 domain.	Hydrogen	75-83	lactalbumin alpha	Homo sapiens	266-283
18299748-7	2008	However, it was still possible to relate the 1H NMR signal obtained at a flow rate of 60 mL min(-1) to the composition of the reactor contents.	Hydrogen	45-47	CD59 molecule (CD59 blood group)	Homo sapiens	92-98
18249539-4	2008	Herein, we replaced acidic moieties at the P(4) position with other hydrogen bond acceptor groups, and these inhibitors exhibited improved BACE1 inhibitory activities in cultured cells.	Hydrogen	68-76	beta-secretase 1	Homo sapiens	139-144
18328313-2	2008	Different mixtures of gases (He and H2) were tested using HCl conditions and a He flow rate of 4 mL min(-1) was found to be suitable for the removal of the poly-atomic spectral interference [40Ar35Cl]+.	Hydrogen	36-38	CD59 molecule (CD59 blood group)	Homo sapiens	100-106
18275186-0	2008	Theoretical study of specific hydrogen-bonding effects on the bridging P-OR bond strength of phosphate monoester dianions.	Hydrogen	30-38	cytochrome p450 oxidoreductase	Homo sapiens	71-75
18275186-3	2008	The potential catalytic effect of this type of interaction, with regard to P-OR bond cleavage, was investigated computationally through simple model systems in which an efficient intramolecular hydrogen bond can take place between a H-bond donor group and the bridging oxygen atom of the dianionic phosphate.	Hydrogen	194-202	cytochrome p450 oxidoreductase	Homo sapiens	75-79
18053681-7	2008	The expression of EGFR and ErbB2 receptors was significantly reduced after 1h and 4h of treatment while ErbB2 receptor was significantly increased and EGFR receptor returned to basal value after 24h.	Hydrogen	75-77	epidermal growth factor receptor	Homo sapiens	18-22
19083400-8	2008	Hydrogen-rich water intake was also associated with a trend of decreased serum concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and extracellular-superoxide dismutase.	Hydrogen	0-8	adiponectin, C1Q and collagen domain containing	Homo sapiens	163-174
19083400-10	2008	In conclusion, these results suggest that supplementation with hydrogen-rich water may have a beneficial role in prevention of T2DM and insulin resistance.	Hydrogen	63-71	insulin	Homo sapiens	136-143
17910058-3	2008	LRH-1/phospholipid and LRH-1/SHP (fragments) interactions are analyzed by counting atomic contact number, identifying hydrogen bonds, and estimating binding free energies (by MM-PB/SA and N-mode analysis).	Hydrogen	118-126	nuclear receptor subfamily 5 group A member 2	Homo sapiens	0-5
17910058-3	2008	LRH-1/phospholipid and LRH-1/SHP (fragments) interactions are analyzed by counting atomic contact number, identifying hydrogen bonds, and estimating binding free energies (by MM-PB/SA and N-mode analysis).	Hydrogen	118-126	nuclear receptor subfamily 5 group A member 2	Homo sapiens	23-28
18053681-7	2008	The expression of EGFR and ErbB2 receptors was significantly reduced after 1h and 4h of treatment while ErbB2 receptor was significantly increased and EGFR receptor returned to basal value after 24h.	Hydrogen	75-77	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-32
18054952-6	2008	The results revealed that statherin adsorbed at a greater extent onto the HA as compared to StN21, suggesting that the hydrogen bonding between the uncharged polar residues at the C-terminal region of statherin and HA contributes to its adsorption.	Hydrogen	119-127	statherin	Homo sapiens	26-35
18319626-0	2008	Backbone 1H, 15N, and 13C resonance assignments and secondary-structure of the conserved hypothetical protein HP0892 of Helicobacter pylori.	Hydrogen	9-11	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	Helicobacter pylori 26695	110-116
18301754-7	2008	These oligomers are formed through oxidation of the two free cysteines of SOD1 (6 and 111) and stabilized by hydrogen bonds, between beta strands, thus forming amyloid-like structures.	Hydrogen	109-117	superoxide dismutase 1	Homo sapiens	74-78
18054952-6	2008	The results revealed that statherin adsorbed at a greater extent onto the HA as compared to StN21, suggesting that the hydrogen bonding between the uncharged polar residues at the C-terminal region of statherin and HA contributes to its adsorption.	Hydrogen	119-127	statherin	Homo sapiens	201-210
18226895-6	2008	The analysis shows that the presence of tertiary hydrogen bond acceptor groups is important for CCR2 antagonism.	Hydrogen	49-57	C-C motif chemokine receptor 2	Homo sapiens	96-100
18023482-1	2008	Backbone dynamics of the camphor monoxygenase cytochrome P450(cam) (CYP101) as a function of oxidation/ligation state of the heme iron were investigated via hydrogen/deuterium exchange (H/D exchange) as monitored by mass spectrometry.	Hydrogen	157-165	calmodulin 3	Homo sapiens	46-66
18088596-1	2008	Structural analysis of MRP1-NBD1 revealed that the Walker A S685 forms hydrogen-bond with the Walker B D792 and interacts with magnesium and the beta-phosphate of the bound ATP.	Hydrogen	71-79	ATP binding cassette subfamily C member 1	Homo sapiens	23-27
17502122-4	2008	The ATP binding pocket of Chk1 seems to be adaptable to substitution of the nitrogen of the imide E heterocycle with a hydroxymethyl group, allowing the fundamental hydrogen bond with the Glu(85) residue of the enzyme.	Hydrogen	165-173	checkpoint kinase 1	Homo sapiens	26-30
18216254-0	2008	Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1.	Hydrogen	37-45	seed linoleate 13S-lipoxygenase-1	Glycine max	109-123
17928249-6	2008	Toxicophore model generated using HypoGen module in Catalyst, on these datasets, showed three important features for hERG K+ channel blockers, (i) hydrophobic group (HP), (ii) ring aromatic group (RA) and (iii) hydrogen bond acceptor lipid group (HBAl).	Hydrogen	211-219	ETS transcription factor ERG	Homo sapiens	117-121
18166050-8	2008	In uracil and 4-cyano-4"-ethynylbiphenyl, the CH hydrogen-bonding donors are sp2 and sp hybridized, respectively; a comparison of the calculated changes in 1H chemical shift with those for the sp3 hybridized CH donors in maltose (Yates et al.	Hydrogen	49-57	Sp2 transcription factor	Homo sapiens	77-80
18166050-8	2008	In uracil and 4-cyano-4"-ethynylbiphenyl, the CH hydrogen-bonding donors are sp2 and sp hybridized, respectively; a comparison of the calculated changes in 1H chemical shift with those for the sp3 hybridized CH donors in maltose (Yates et al.	Hydrogen	156-158	Sp2 transcription factor	Homo sapiens	77-80
18175010-3	2008	The yield of hydrogen-labelled product DHAP remains constant as the concentration of the basic form of imidazole buffer is increased from 0.014 to 0.56 M. This shows that the active site of free TIM, which has an open conformation needed to allow substrate binding, adopts a closed conformation at the enediolate-complex intermediate where the catalytic side chain is sequestered from interaction with imidazole dissolved in D2O.	Hydrogen	13-21	triosephosphate isomerase 1	Homo sapiens	195-198
18175010-0	2008	Slow proton transfer from the hydrogen-labelled carboxylic acid side chain (Glu-165) of triosephosphate isomerase to imidazole buffer in D2O.	Hydrogen	30-38	triosephosphate isomerase 1	Homo sapiens	88-113
18078705-11	2008	Treatment with APAP for 1h caused a significant increase in the levels of haem oxygenase-1 (HO-1; 2.85-fold) and glutamate cysteine ligase (GCLC; 1.62-fold) mRNA.	Hydrogen	24-26	heme oxygenase 1	Mus musculus	74-90
18078705-11	2008	Treatment with APAP for 1h caused a significant increase in the levels of haem oxygenase-1 (HO-1; 2.85-fold) and glutamate cysteine ligase (GCLC; 1.62-fold) mRNA.	Hydrogen	24-26	heme oxygenase 1	Mus musculus	92-96
18021806-2	2008	We have determined the structured core of human stefin B (cystatin B) amyloid fibrils using quenched hydrogen exchange and NMR.	Hydrogen	101-109	cystatin B	Homo sapiens	58-68
18081314-3	2008	The detailed conformational change and 3D structure of the PGIS-bound U46619 were further demonstrated by 2D 1H NMR experiments using the transferred NOE technique.	Hydrogen	109-111	prostaglandin I2 synthase	Homo sapiens	59-63
18165316-7	2008	A homology model of hL1 Ig1-4 (residues 33-422), based on the structure of the Ig1-4 domains of axonin-1, suggests that Glu-33 and Tyr-418 hydrogen-bond at the interface of Ig1 and Ig4 to stabilize a horseshoe conformation of L1 that favors homophilic binding.	Hydrogen	139-147	L1 cell adhesion molecule	Homo sapiens	20-23
18165316-7	2008	A homology model of hL1 Ig1-4 (residues 33-422), based on the structure of the Ig1-4 domains of axonin-1, suggests that Glu-33 and Tyr-418 hydrogen-bond at the interface of Ig1 and Ig4 to stabilize a horseshoe conformation of L1 that favors homophilic binding.	Hydrogen	139-147	L1 cell adhesion molecule	Homo sapiens	21-23
18023291-14	2008	The Bcl-2/Bax mRNA ratio was 0.11 in the absence of TP508 at 1h and 4.95 at 7microg/ml TP508; by 3h the ratio was approximately 1 in both groups.	Hydrogen	61-63	BCL2 apoptosis regulator	Homo sapiens	4-9
17935687-5	2008	Moreover, a few conserved interactions observed in the X-ray structure of rhodopsin, such as inter-helical sidechain-sidechain hydrogen bonds were accurately reproduced in the MD simulation.	Hydrogen	127-135	rhodopsin	Homo sapiens	74-83
18023291-14	2008	The Bcl-2/Bax mRNA ratio was 0.11 in the absence of TP508 at 1h and 4.95 at 7microg/ml TP508; by 3h the ratio was approximately 1 in both groups.	Hydrogen	61-63	BCL2 associated X, apoptosis regulator	Homo sapiens	10-13
18023291-15	2008	The Bcl-2/Bax protein ratio also increased by 63% at 1h.	Hydrogen	53-55	BCL2 apoptosis regulator	Homo sapiens	4-9
18023291-15	2008	The Bcl-2/Bax protein ratio also increased by 63% at 1h.	Hydrogen	53-55	BCL2 associated X, apoptosis regulator	Homo sapiens	10-13
17905586-2	2008	New 7-alkoxy-4-phenylamino-3-quinolinecarbonitrile Src inhibitors were prepared from 5 and 9, the 6-ethoxy and 6-hydrogen analogs of 2.	Hydrogen	113-121	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	51-54
18159930-2	2008	Insulin loaded nanoparticles were obtained by the formation of hydrogen bonds between poly(vinyl pyrrolidone) (PVP) and poly(acrylic acid)-cysteine (PAA-Cys) or poly(acrylic acid) (PAA), respectively, in the presence of insulin.	Hydrogen	63-71	insulin	Homo sapiens	0-7
18488499-1	2008	An IR-spectroscopy study of the mechanism of interaction between duplex CC(GCC)5/GG (CGG)5Li2 and tetrahydrocortisol or tetrahydrocortisol-apolipoprotein A-I complex revealed the formation of hydrogen bonds between the OH group of the tetrahydrocortisol A-ring and the C=0 group of cytosine or guanine.	Hydrogen	192-200	apolipoprotein A1	Homo sapiens	139-157
18661333-3	2008	This ubiquitously expressed sodium/hydrogen exchanger (NHE-1) plays a central housekeeping role in all cells regulating cell volume and internal pH (pHi).	Hydrogen	35-43	solute carrier family 9 member A1	Homo sapiens	55-60
18058821-5	2008	Docking of Ac-pTyr-Leu-Pro-Gln-NHBn to the SH2 domain of Stat3 using molecular modeling showed that the Gln binds tightly in this pocket and participates in a network of hydrogen bonds.	Hydrogen	170-178	signal transducer and activator of transcription 3	Homo sapiens	57-62
18792040-3	2008	However, spectrophotometric studies in CHCl3 solution have shown that only the poorly basic NO3 - ion is able to form authentic hydrogen-bond complexes with thiourea subunits, whereas all the other investigated anions (CH3COO-, NO2 -, F-) induce deprotonation of the N-H fragment.	Hydrogen	128-136	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
18661333-4	2008	At physiological pHi, NHE-1 is essentially inactive but it is extremely sensitive to pHi changes, being rapidly activated by small intracellular hydrogen concentration increases.	Hydrogen	145-153	solute carrier family 9 member A1	Homo sapiens	22-27
17825420-4	2008	It was evidenced that Cp is released free in solution after VIV binding to transferrin by 1H NMR measurements.	Hydrogen	90-92	transferrin	Homo sapiens	75-86
18071845-1	2008	The rate of ascorbate and nicotinamide adenine dinucleotide plus hydrogen (NADH) cooxidation (i.e., their nonenzymic oxidation by peroxidase/H2O2-generated phenoxyl radicals of three hydroxycinnamates: caffeate, ferulate and p-coumarate) was studied in vitro.	Hydrogen	65-73	peroxidase	Glycine max	130-140
18609141-9	2008	A weak correlation between hydrogen excretion and PYY levels was demonstrated in non-producers of methane.	Hydrogen	27-35	peptide YY	Homo sapiens	50-53
18220969-7	2008	The docking calculations showed that all compounds have good affinities for COX I and COX II ( identical with 1 microM), making pi-pi, van der Waals interactions and hydrogen bonds.	Hydrogen	166-174	cytochrome c oxidase I, mitochondrial	Mus musculus	76-81
17944992-9	2008	This was confirmed by docking studies, which revealed that MAA forms a strong hydrogen bond with serine 530 within the COX-1, thereby preventing enzyme acetylation by aspirin.	Hydrogen	78-86	prostaglandin-endoperoxide synthase 1	Homo sapiens	119-124
18020364-5	2007	With our proposed proton-transfer fluorescence probing method, we were able to show that the conformation of 1a-f bearing a not highly electron-withdrawing substituent was switched to the "open-ring" form by H2PO4-, whereas 1h bearing a highly electron-withdrawing substituent, p-CN, remained in the "closed-ring" conformation.	Hydrogen	224-226	pericentrin	Homo sapiens	278-282
17949766-6	2008	Structural analysis of the NCI 122-ERalpha LBD-GRIP1 complex, combined with biochemical and cell-based comparisons of CEE components, suggests that factors such as decreased ligand flexibility, decreased ligand hydrophobicity and loss of a hydrogen bond between the 17-hydroxyl group and His524, contribute significantly to the reduced potency of CEEs on ERalpha.	Hydrogen	240-248	glutamate receptor interacting protein 1	Equus caballus	47-52
17996243-8	2007	Molecular surface analysis with the MOLCAD program reveals that electrostatic interactions and hydrogen bonds (H-bonds) contribute to the affinity interactions between the tetrapeptide and t-PA.	Hydrogen	95-103	plasminogen activator, tissue type	Homo sapiens	189-193
18034684-4	2007	The results revealed the significant roles of steric effect, hydrogen bonding and electronic properties on the p38 inhibitory activity of the studied molecules.	Hydrogen	61-69	mitogen-activated protein kinase 14	Homo sapiens	111-114
18031619-11	2007	Compound F, a potent agent for COX-2, revealed a strong hydrogen bond with Ser516 in human COX-2 to form a stable complex.	Hydrogen	56-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
18031619-11	2007	Compound F, a potent agent for COX-2, revealed a strong hydrogen bond with Ser516 in human COX-2 to form a stable complex.	Hydrogen	56-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
18035040-7	2007	Close to complete NMR resonance assignment of the 1H, 13C, and 15N spins of CD4mut was accomplished.	Hydrogen	50-52	CD4 molecule	Homo sapiens	76-82
17952367-0	2007	A hydrogen-bonding network in mammalian sorbitol dehydrogenase stabilizes the tetrameric state and is essential for the catalytic power.	Hydrogen	2-10	sorbitol dehydrogenase	Homo sapiens	40-62
17952367-1	2007	Subunit interaction in sorbitol dehydrogenase (SDH) has been studied with in vitro and in silico methods identifying a vital hydrogen-bonding network, which is strictly conserved among mammalian SDH proteins.	Hydrogen	34-42	sorbitol dehydrogenase	Homo sapiens	47-50
17952367-1	2007	Subunit interaction in sorbitol dehydrogenase (SDH) has been studied with in vitro and in silico methods identifying a vital hydrogen-bonding network, which is strictly conserved among mammalian SDH proteins.	Hydrogen	34-42	sorbitol dehydrogenase	Homo sapiens	195-198
17952367-2	2007	Mutation of one of the residues in the hydrogen-bonding network, Tyr110Phe, abolished the enzymatic activity and destabilized the protein into tetramers, dimers and monomers as judged from gel filtration experiments at different temperatures compared to only tetramers for the wild-type protein below 307 K. The determined equilibrium constants revealed a large difference in Gibbs energy (8 kJ/mol) for the tetramer stability between wild-type SDH and the mutated form Tyr110Phe SDH.	Hydrogen	39-47	sorbitol dehydrogenase	Homo sapiens	445-448
17952367-2	2007	Mutation of one of the residues in the hydrogen-bonding network, Tyr110Phe, abolished the enzymatic activity and destabilized the protein into tetramers, dimers and monomers as judged from gel filtration experiments at different temperatures compared to only tetramers for the wild-type protein below 307 K. The determined equilibrium constants revealed a large difference in Gibbs energy (8 kJ/mol) for the tetramer stability between wild-type SDH and the mutated form Tyr110Phe SDH.	Hydrogen	39-47	sorbitol dehydrogenase	Homo sapiens	480-483
17952367-3	2007	The results focus on a network of coupled hydrogen bonds in wild-type SDH that uphold the protein interface, which is specific and favorable to electrostatic, van der Waals and hydrogen-bond interactions between subunits, interactions that are crucial for the catalytic power of SDH.	Hydrogen	42-50	sorbitol dehydrogenase	Homo sapiens	70-73
17952367-3	2007	The results focus on a network of coupled hydrogen bonds in wild-type SDH that uphold the protein interface, which is specific and favorable to electrostatic, van der Waals and hydrogen-bond interactions between subunits, interactions that are crucial for the catalytic power of SDH.	Hydrogen	42-50	sorbitol dehydrogenase	Homo sapiens	279-282
17952367-3	2007	The results focus on a network of coupled hydrogen bonds in wild-type SDH that uphold the protein interface, which is specific and favorable to electrostatic, van der Waals and hydrogen-bond interactions between subunits, interactions that are crucial for the catalytic power of SDH.	Hydrogen	177-185	sorbitol dehydrogenase	Homo sapiens	70-73
17952367-3	2007	The results focus on a network of coupled hydrogen bonds in wild-type SDH that uphold the protein interface, which is specific and favorable to electrostatic, van der Waals and hydrogen-bond interactions between subunits, interactions that are crucial for the catalytic power of SDH.	Hydrogen	177-185	sorbitol dehydrogenase	Homo sapiens	279-282
17927211-4	2007	1H, 13C, and 15N resonance assignments revealed very similar types and locations of secondary structural elements for apo- and holo-LFABP as judged from chemical shift indices.	Hydrogen	0-2	fatty acid binding protein 1	Rattus norvegicus	132-137
17920295-7	2007	A circular dichroism spectrum indicated that the PLC-eta1 PH domain mainly comprised beta-strands, which was also suggested by the 2D 1H-15N HSQC spectrum.	Hydrogen	134-136	phospholipase C eta 1	Homo sapiens	49-57
17965186-0	2007	Phosphoinositide binding regulates alpha-actinin CH2 domain structure: analysis by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	83-91	actinin alpha 1	Homo sapiens	35-48
17965186-3	2007	In this study, we examine the mechanism by which phosphoinositide binding regulates alpha-actinin function using mass spectrometry to monitor hydrogen-deuterium (H/D) exchange within the calponin homology 2 domain.	Hydrogen	142-150	actinin alpha 1	Homo sapiens	84-97
17973360-2	2007	Docking simulations indicated that ligand-nAChR complexes were formed by hydrophobic interactions with the cleft and hydrogen bond interactions.	Hydrogen	117-125	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	42-47
17979301-2	2007	Cocrystal structures of PDE5 catalytic (C) domain with inhibitors reveal a hydrogen bond and hydrophobic interactions with Tyr-612, hydrogen bonds with Gln-817, a hydrophobic clamp formed by Phe-820 and Val-782, and contacts with His-613, Leu-765, and Phe-786 [Sung et al.	Hydrogen	75-83	phosphodiesterase 5A	Homo sapiens	24-28
17979301-2	2007	Cocrystal structures of PDE5 catalytic (C) domain with inhibitors reveal a hydrogen bond and hydrophobic interactions with Tyr-612, hydrogen bonds with Gln-817, a hydrophobic clamp formed by Phe-820 and Val-782, and contacts with His-613, Leu-765, and Phe-786 [Sung et al.	Hydrogen	132-140	phosphodiesterase 5A	Homo sapiens	24-28
17941649-5	2007	The presence of E-R/K (i, i + 4) ion pairs was expected to enhance the stability of the alpha-helix by introducing favorable electrostatic interactions at the side chain level, in addition to the characteristic backbone (i, i + 4) hydrogen bonds.	Hydrogen	231-239	PPP1R2C family member C	Homo sapiens	16-31
17941649-5	2007	The presence of E-R/K (i, i + 4) ion pairs was expected to enhance the stability of the alpha-helix by introducing favorable electrostatic interactions at the side chain level, in addition to the characteristic backbone (i, i + 4) hydrogen bonds.	Hydrogen	231-239	PPP1R2C family member C	Homo sapiens	26-31
17761672-12	2007	Interestingly, the capacity of wild type EXT2 to enhance HS chain length together with EXT1 was not shared by the EXT2-Y419X mutant.	Hydrogen	57-59	exostosin glycosyltransferase 2	Homo sapiens	41-45
17937482-0	2007	Catalytic coupling of sp2- and sp-hybridized carbon-hydrogen bonds with vinylmetalloid compounds.	Hydrogen	52-60	Sp2 transcription factor	Homo sapiens	22-25
17258781-7	2007	With respect to innate immunity, TLR4-deficient C3H/HeJ mice are more susceptible to polyaromatic hydrogen skin tumorigenesis than C3H/HeN mice in which TLR4 is normal.	Hydrogen	98-106	toll-like receptor 4	Mus musculus	33-37
17914811-7	2007	Guanosine 5"-diphosphate (5"-GDP), with a ribose moiety and a Re(I)-binding base, formed both possible diastereomers (RRe and SRe) of the fac-[Re(CO)3(H2O)({N7,Pbeta}GDP)]- macrochelate, with one slightly more abundant diastereomer suggested to be RRe by Mn2+ ion 1H NMR signal line-broadening combined with distances from molecular models.	Hydrogen	264-266	FA complementation group C	Homo sapiens	138-141
17765202-3	2007	Here, to elucidate the relationship between the trimeric stability and the apoptotic activity of TRAIL(C230A), we rationally designed mutations to induce homotrimerization of TRAIL(C230A) by substituting for the three residues involved in hydrogen bonding (Tyr183 and Tyr243) and putative repulsive electrostatic (Arg227) interactions at the buried trimeric interface into hydrophobic residues, like Y183F, Y243F, and R227I.	Hydrogen	239-247	TNF superfamily member 10	Homo sapiens	97-102
17765202-3	2007	Here, to elucidate the relationship between the trimeric stability and the apoptotic activity of TRAIL(C230A), we rationally designed mutations to induce homotrimerization of TRAIL(C230A) by substituting for the three residues involved in hydrogen bonding (Tyr183 and Tyr243) and putative repulsive electrostatic (Arg227) interactions at the buried trimeric interface into hydrophobic residues, like Y183F, Y243F, and R227I.	Hydrogen	239-247	TNF superfamily member 10	Homo sapiens	175-180
17939742-10	2007	The determined hydrogen-donating abilities of the matrixes are ranked as follows: picolinic acid (PA) &gt; 1,5-diaminonaphtalene (1,5-DAN) &gt; DHB &gt; sinapinic acid &gt; alpha-cyano-4-hydroxycinnamic acid.	Hydrogen	15-23	NBL1, DAN family BMP antagonist	Homo sapiens	134-137
17553644-4	2007	We applied human recombinant IL-6 intra-nasally to developing rats 1h before seizures induced by moist heated air (50 degrees C).	Hydrogen	67-69	interleukin 6	Homo sapiens	29-33
17573430-6	2007	Whereas p-S8 is found to be well structured, p-S2 is rather flexible, wrapping itself around p-S8 to give rise to the FN, which is stabilized by three particular hydrogen bonds.	Hydrogen	162-170	taste 2 receptor member 64 pseudogene	Homo sapiens	45-49
17804013-8	2007	NMR detected hydrogen/deuterium exchange and the analysis of truncated variants showed that the C-terminal repeats ANK3-5 are already folded in the on-pathway intermediate, whereas the N-terminal repeats 1 and 2 are not folded.	Hydrogen	13-21	ankyrin 3	Homo sapiens	115-119
17601647-0	2007	Interactions of Lycopodium alkaloids with acetylcholinesterase investigated by 1H NMR relaxation rate.	Hydrogen	79-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-62
17720492-1	2007	A new series of CCR2 antagonists has been discovered that incorporates intramolecular hydrogen bonding as a strategy for rigidifying the scaffold.	Hydrogen	86-94	C-C motif chemokine receptor 2	Homo sapiens	16-20
17517919-3	2007	The data suggest that IFN afacon-1 has 9 optimal interactions with IFNAR2, comprising hydrophobic, electrostatic, and hydrogen bonding.	Hydrogen	118-126	interferon alpha 1	Homo sapiens	22-25
17655339-0	2007	1H NMR spectroscopic investigations on the micellization and gelation of PEO-PPO-PEO block copolymers in aqueous solutions.	Hydrogen	0-2	protoporphyrinogen oxidase	Homo sapiens	77-80
17685503-2	2007	X-ray crystallography revealed that the exocyclic amino group participated in a hydrogen bonding array with the two catalytic aspartic acids of BACE-1 (Asp(32), Asp(228)).	Hydrogen	80-88	beta-secretase 1	Homo sapiens	144-150
17691766-8	2007	1H NMR and circular dichroism (CD) spectroscopy report on the metal environment and prove to be diagnostic for syn or anti diastereomers, and we identified characteristic features from these techniques that can be used to assign the diastereomer profile in 99mTc peptide radiopharmaceuticals like [99mTcO]depreotide and in 188Re peptide radiotherapeutic agents.	Hydrogen	0-2	joined toes	Mus musculus	111-114
17937775-2	2007	Favourable hydrogen bonds between ligand and NQO1, and parallel orientation between ligand and flavin adenine dinucleotide could explain the difference of metabolism rate (in micromol/min/mg) for quinone analogues.	Hydrogen	11-19	NAD(P)H quinone dehydrogenase 1	Homo sapiens	45-49
17764167-1	2007	The oil-induced aggregation behavior of PEO-PPO-PEO Pluronic P84 [(EO)19(PO)39(EO)19] in aqueous solutions has been systematically investigated by 1H NMR spectroscopy, freeze-fracture transmission electron microscopy (FF-TEM), and dynamic light scattering (DLS).	Hydrogen	147-149	protoporphyrinogen oxidase	Homo sapiens	44-47
17889651-5	2007	An extensive hydrogen-bonding network, as well as hydrophobic interactions, between TLR1 and TLR2 further stabilize the heterodimer.	Hydrogen	13-21	toll like receptor 1	Homo sapiens	84-88
17889651-5	2007	An extensive hydrogen-bonding network, as well as hydrophobic interactions, between TLR1 and TLR2 further stabilize the heterodimer.	Hydrogen	13-21	toll like receptor 2	Homo sapiens	93-97
17715970-1	2007	A nanosecond time-resolved resonance Raman (ns-TR3) spectroscopic study of the triplet state benzophenone reaction with the 2-propanol hydrogen-donor solvent and subsequent reactions is presented.	Hydrogen	135-143	nuclear receptor subfamily 4 group A member 1	Homo sapiens	47-50
17715970-2	2007	The TR3 spectra show that the benzophenone triplet state (npi*) hydrogen-abstraction reaction with 2-propanol is very fast (about 10 to 20 ns) and forms a diphenylketyl radical and an associated 2-propanol radical partner.	Hydrogen	64-72	nuclear receptor subfamily 4 group A member 1	Homo sapiens	4-7
17601647-5	2007	The results indicate that investigation of 1H NMR relaxation data is a useful method to locate the new Lycopodium alkaloids as AchE inhibitors.	Hydrogen	43-45	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131
17537872-14	2007	Both models possessed a hydrogen bond acceptor and represent an approach for predicting CYP3A4 MIC formation that can be improved using more data and molecular descriptors.	Hydrogen	24-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	88-94
17350298-3	2007	iNOS specificity of inhibitor 2 is attributed to water mediated interactions and cooperative hydrogen bond networks.	Hydrogen	93-101	nitric oxide synthase 2	Homo sapiens	0-4
17718553-9	2007	The five hydrogen bonds between Arg24 in ShK and H404(A) and D402(D) in Kv1.3 make Arg24 the most crucial for its binding to the Kv1.3 channel.	Hydrogen	9-17	potassium voltage-gated channel, shaker-related subfamily, member 3	Mus musculus	72-77
17718553-9	2007	The five hydrogen bonds between Arg24 in ShK and H404(A) and D402(D) in Kv1.3 make Arg24 the most crucial for its binding to the Kv1.3 channel.	Hydrogen	9-17	potassium voltage-gated channel, shaker-related subfamily, member 3	Mus musculus	129-134
26627620-1	2007	We have developed force-field parameters for the hydrogen-abstraction transition state of aliphatic hydroxylation by cytochrome P450 using the Q2MM approach.	Hydrogen	49-57	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	117-132
17658776-5	2007	Two important binding interactions between compound 46b and Chk1 kinase, revealed by X-ray cocrystal structure, were hydrogen bonds between the hinge region and the amide bond of the core structure and a hydrogen bond between the methoxy group and Lys38 of the protein.	Hydrogen	117-125	checkpoint kinase 1	Homo sapiens	60-64
17576789-8	2007	In contrast, a qualitative comparison with the corresponding PXR antagonist pharmacophore models using azoles and biphenyls showed that they are smaller and hydrophobic with increased emphasis on hydrogen bonding features.	Hydrogen	196-204	nuclear receptor subfamily 1 group I member 2	Homo sapiens	61-64
17660254-2	2007	The present work used native state hydrogen exchange methods to investigate a structural anomaly in cytochrome c results that suggested the concerted folding of two segments that have little structural relationship in the native protein.	Hydrogen	35-43	cytochrome c, somatic	Homo sapiens	100-112
17591767-7	2007	The Tyr-874 mutant side chain mediates a new hydrogen bonding scheme from exterior helix-10 to backbone protein core helix-4 residue Tyr-739 to rescue T-induced AR activity by improving AF2 binding of FXXLF and LXXLL motifs.	Hydrogen	45-53	androgen receptor	Homo sapiens	161-163
17658776-5	2007	Two important binding interactions between compound 46b and Chk1 kinase, revealed by X-ray cocrystal structure, were hydrogen bonds between the hinge region and the amide bond of the core structure and a hydrogen bond between the methoxy group and Lys38 of the protein.	Hydrogen	204-212	checkpoint kinase 1	Homo sapiens	60-64
17544169-3	2007	Cell treatment with 100 nM VIP for 1h before xenograft resulted in increased tumor growth after 8 and, more remarkably, 15 days of injection.	Hydrogen	35-37	vasoactive intestinal peptide	Homo sapiens	27-30
17663562-1	2007	A beta-tetrapeptide made up of homochiral cyclobutane residues displays conformational bias in solution prompted by the formation of intramolecular hydrogen bonds.	Hydrogen	148-156	amyloid beta precursor protein	Homo sapiens	0-6
17594907-2	2007	The simulations suggest that the mechanical stability of the tenth type III domain from fibronectin (FNfn10) is largely determined by a number of critical hydrogen bonds in the peripheral strands.	Hydrogen	155-163	fibronectin 1	Homo sapiens	88-99
17636870-6	2007	Limited trypsin digestion analysis and 1H-15N chemical shift perturbation data reveal that the flexibility of certain portions of the protein backbone is increased in the partially structured state(s) of aFGF.	Hydrogen	39-41	fibroblast growth factor 1	Homo sapiens	204-208
17655222-7	2007	However, for fac-Re(CO)3(DNS-dien), both chelate rings have the same pucker chirality because the sulfonamido ring has an unusual pucker for the absolute configuration at Re; a finding that is attributable to intramolecular and intermolecular hydrogen bonds from the sulfonamido oxygens to the NH2 groups.	Hydrogen	243-251	FA complementation group C	Homo sapiens	13-16
17625837-8	2007	In the presence of H2(g) and stoichiometric amounts of PPh3, the cod-Rh(I) reagents, 1, 3, and 5, afford the salts [Rh(H)2(L2)(PPh3)2][SB9H12] [L2 = bpy (19), Me2bpy (20), phen (21)].	Hydrogen	19-21	caveolin 1	Homo sapiens	127-131
17570393-5	2007	Differences in flexibility between bound and free LC8 were evaluated from hydrogen isotope exchange experiments using heteronuclear NMR spectroscopy.	Hydrogen	74-82	cut up	Drosophila melanogaster	50-53
17602556-2	2007	The complexes with more positive Co(II/I) redox potentials exhibited lower activity for H2 production.	Hydrogen	88-90	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	33-40
17568610-5	2007	We studied equilibrium unfolding of wild-type alpha(1)-AT using hydrogen-deuterium/exchange mass spectrometry to characterize the structure and the stability of an equilibrium intermediate that was observed in low concentrations of denaturant in earlier studies.	Hydrogen	64-72	serpin family A member 1	Homo sapiens	46-57
17608422-3	2007	Synthetic 3-, 4-, and 6-deoxy-LeX variants were also shown to form complexes in the presence of calcium ions, despite the replacement of one of their hydroxyl groups by hydrogen atoms.	Hydrogen	169-177	fucosyltransferase 4	Homo sapiens	30-33
17875556-5	2007	The 1,645-cm(-1) band containing C(2)=O stretching vibration shifted to 1,630 cm(-1) in the medium-chain acyl-CoA dehydrogenase (MCAD)-bound state, which can be explained by hydrogen bonds at C(2)=O of the flavin ring.	Hydrogen	116-124	acyl-CoA dehydrogenase medium chain	Homo sapiens	129-133
17512736-11	2007	It is likely that the hydroxyl groups facilitate RSK binding through their ability to form hydrogen bonds.	Hydrogen	91-99	ribosomal protein S6 kinase A2	Homo sapiens	49-52
17600621-10	2007	Specifically, pretreatment of neurons with 10 microM PAN-811 (an optimal neuroprotective concentration) for 1h, 4h, or 24h significantly suppresses glutamate-mediated activation of both JNK and p38 MAPK.	Hydrogen	108-110	mitogen-activated protein kinase 8	Homo sapiens	186-189
17459884-5	2007	The NEP hairpin, although lacking the typical inter-chain hydrogen bond but is stabilized by hydrogen bonds with the main chain and side chains of subdomain C, directs the C-terminal basic region of the NEP peptide away from the groove and toward the membrane.	Hydrogen	58-66	membrane metalloendopeptidase	Homo sapiens	4-7
17459884-5	2007	The NEP hairpin, although lacking the typical inter-chain hydrogen bond but is stabilized by hydrogen bonds with the main chain and side chains of subdomain C, directs the C-terminal basic region of the NEP peptide away from the groove and toward the membrane.	Hydrogen	58-66	membrane metalloendopeptidase	Homo sapiens	203-206
17459884-5	2007	The NEP hairpin, although lacking the typical inter-chain hydrogen bond but is stabilized by hydrogen bonds with the main chain and side chains of subdomain C, directs the C-terminal basic region of the NEP peptide away from the groove and toward the membrane.	Hydrogen	93-101	membrane metalloendopeptidase	Homo sapiens	4-7
17459884-5	2007	The NEP hairpin, although lacking the typical inter-chain hydrogen bond but is stabilized by hydrogen bonds with the main chain and side chains of subdomain C, directs the C-terminal basic region of the NEP peptide away from the groove and toward the membrane.	Hydrogen	93-101	membrane metalloendopeptidase	Homo sapiens	203-206
17627346-3	2007	Possible stabilization of the OH(3) (-) DRA through hydrogen bonding or ion-dipole interactions is examined through calculations on O(2)H(5) (-) species.	Hydrogen	52-60	solute carrier family 26 member 3	Homo sapiens	40-43
17600621-10	2007	Specifically, pretreatment of neurons with 10 microM PAN-811 (an optimal neuroprotective concentration) for 1h, 4h, or 24h significantly suppresses glutamate-mediated activation of both JNK and p38 MAPK.	Hydrogen	108-110	mitogen-activated protein kinase 14	Homo sapiens	194-197
17509522-6	2007	The resultant functions indicated that both specific and nonspecific associations of antibody molecules with fibrinogen occurred through a variety of molecular interactions, including hydrophophic, ionic and hydrogen bonding mechanisms.	Hydrogen	208-216	fibrinogen beta chain	Homo sapiens	109-119
17490599-2	2007	Hydrogen/deuterium (H/D) exchange with electrospray ionization mass spectrometry was applied to lyophilized powders containing calmodulin (17 kDa) and exposed to D(2)O vapor at controlled relative humidity (RH) and temperature.	Hydrogen	0-8	calmodulin 1	Homo sapiens	127-137
17565280-1	2007	PURPOSE OF REVIEW: The sodium-hydrogen exchanger isoform-1 (NHE1) functions in intracellular pH and cell volume homeostasis by catalyzing an electroneutral exchange of extracellular sodium and intracellular hydrogen.	Hydrogen	30-38	solute carrier family 9 member A1	Homo sapiens	60-64
19636848-0	2007	1H, 15N and 13C backbone and side chain chemical shifts of human ASC (apoptosis-associated speck-like protein containing a CARD domain).	Hydrogen	0-2	PYD and CARD domain containing	Homo sapiens	65-68
17509054-7	2007	Patients with an abnormally low serum B12 level underwent both a Schilling and a hydrogen breath test.	Hydrogen	81-89	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	38-41
19636824-0	2007	Backbone 1H, 13C, and 15N resonance assignments for the 26-kD human de-ubiquitinating enzyme UCH-L3.	Hydrogen	9-11	ubiquitin C-terminal hydrolase L3	Homo sapiens	93-99
19636832-0	2007	1H, 15N, and 13C chemical shift assignments of calcium-binding protein 1 (CaBP1).	Hydrogen	0-2	calcium binding protein 1	Homo sapiens	47-72
19636832-0	2007	1H, 15N, and 13C chemical shift assignments of calcium-binding protein 1 (CaBP1).	Hydrogen	0-2	calcium binding protein 1	Homo sapiens	74-79
19636837-0	2007	Backbone and sidechain 1H, 13C and 15N resonance assignments of the RGS domain from human RGS14.	Hydrogen	23-25	paired like homeodomain 2	Homo sapiens	68-71
19636837-1	2007	We have assigned 1H, 13C and 15N resonances of the RGS domain from the human RGS14 protein, a multi-domain member of the RGS (Regulators of G-protein signalling) family of proteins, important in the down-regulation of specific G-protein signalling pathways.	Hydrogen	17-19	paired like homeodomain 2	Homo sapiens	51-54
19636837-1	2007	We have assigned 1H, 13C and 15N resonances of the RGS domain from the human RGS14 protein, a multi-domain member of the RGS (Regulators of G-protein signalling) family of proteins, important in the down-regulation of specific G-protein signalling pathways.	Hydrogen	17-19	paired like homeodomain 2	Homo sapiens	77-80
17565280-1	2007	PURPOSE OF REVIEW: The sodium-hydrogen exchanger isoform-1 (NHE1) functions in intracellular pH and cell volume homeostasis by catalyzing an electroneutral exchange of extracellular sodium and intracellular hydrogen.	Hydrogen	207-215	solute carrier family 9 member A1	Homo sapiens	60-64
17514334-5	2007	Magnetic and 1H NMR data at room temperature for 6-8 support the occurrence of an intermediate S = 1 low-lying state for the Co(III) center which is stabilized by the strong donating ability of the fully deprotonated bis-amidate ligands.	Hydrogen	13-15	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	125-132
17485112-8	2007	Theoretical analysis showed that TSA1 could bind to TNF-alpha with more hydrogen bonds and lower binding free energy than the designed domain antibody.	Hydrogen	72-80	lymphocyte antigen 6 family member E	Homo sapiens	33-37
17485112-8	2007	Theoretical analysis showed that TSA1 could bind to TNF-alpha with more hydrogen bonds and lower binding free energy than the designed domain antibody.	Hydrogen	72-80	tumor necrosis factor	Homo sapiens	52-61
17433262-5	2007	CYP3A4 produced a new methyl hydroxylated metabolite from voriconazole, detected by LC/UV and LC/MS/MS and confirmed by 1H and 13C NMR analyses, with K(m) and V(max) values of 11+/-3 microM and 0.10+/-0.01 nmol/min/nmol CYP3A4.	Hydrogen	120-122	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
17433262-5	2007	CYP3A4 produced a new methyl hydroxylated metabolite from voriconazole, detected by LC/UV and LC/MS/MS and confirmed by 1H and 13C NMR analyses, with K(m) and V(max) values of 11+/-3 microM and 0.10+/-0.01 nmol/min/nmol CYP3A4.	Hydrogen	120-122	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	220-226
17497842-4	2007	We found that incorporating unsaturated hydrocarbon substituents and polar, hydrogen-bond-accepting groups were beneficial for rTAAR1 and mTAAR1, respectively, providing compounds that were equipotent or more potent than 1.	Hydrogen	76-84	trace amine-associated receptor 1	Mus musculus	138-144
17428678-3	2007	However, thus far only synthetic peptides corresponding to a HLA-A *0201 restricted HA-1H epitope have been used to generate HA-1H specific T cells.	Hydrogen	87-89	major histocompatibility complex, class I, A	Homo sapiens	61-66
17482207-0	2007	Hydrogen/deuterium exchange mass spectrometric analysis of conformational changes accompanying the assembly of the yeast prion Ure2p into protein fibrils.	Hydrogen	0-8	glutathione peroxidase	Saccharomyces cerevisiae S288C	127-132
17482207-7	2007	Solvent-accessibility studies using hydrogen/deuterium exchange monitored by mass spectrometry (HXMS) can provide insights into the structure of the fibrillar form of Ure2p and characterize at the molecular level the conformational rearrangements that occur upon assembly, in particular through the identification of protected regions and their localization in the overall structure of the protein.	Hydrogen	36-44	glutathione peroxidase	Saccharomyces cerevisiae S288C	167-172
17497889-6	2007	These results suggest that cytochrome c causes a homolytic reaction of LAOOH, generating alkoxyl radical and then peroxyl radical, which in turn releases singlet oxygen following the Russell mechanism, whereas lactoperoxidase leads to a heterolytic reaction of LAOOH, and the resulting ferryl porphyryl radical of lactoperoxidase abstracts the hydrogen atom from LAOOH to give peroxyl radical and then singlet oxygen.	Hydrogen	344-352	cytochrome c, somatic	Homo sapiens	27-39
17497889-6	2007	These results suggest that cytochrome c causes a homolytic reaction of LAOOH, generating alkoxyl radical and then peroxyl radical, which in turn releases singlet oxygen following the Russell mechanism, whereas lactoperoxidase leads to a heterolytic reaction of LAOOH, and the resulting ferryl porphyryl radical of lactoperoxidase abstracts the hydrogen atom from LAOOH to give peroxyl radical and then singlet oxygen.	Hydrogen	344-352	lactoperoxidase	Homo sapiens	210-225
17403665-1	2007	Prostaglandin-endoperoxide H synthase-2 (PGHS-2) shows peroxidase activity to promote the cyclooxygenase reaction for prostaglandin H2, but one of the highly conserved amino acid residues in peroxidases, distal Arg, stabilizing the developing negative charge on the peroxide through a hydrogen-bonding interaction, is replaced with a neutral amino acid residue, Gln.	Hydrogen	285-293	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-39
17180550-0	2007	1H, 13C, and 15N chemical shift assignments for the N-terminal extracellular domain of T-cadherin.	Hydrogen	0-2	cadherin 13	Homo sapiens	87-97
17584122-11	2007	6) Hydrophobic cores are essential for the stability of GH molecule 7) Salt bridges and hydrogen bonds are also important for the binding of the molecule with its receptors.	Hydrogen	88-96	growth hormone 1	Homo sapiens	56-58
17403665-1	2007	Prostaglandin-endoperoxide H synthase-2 (PGHS-2) shows peroxidase activity to promote the cyclooxygenase reaction for prostaglandin H2, but one of the highly conserved amino acid residues in peroxidases, distal Arg, stabilizing the developing negative charge on the peroxide through a hydrogen-bonding interaction, is replaced with a neutral amino acid residue, Gln.	Hydrogen	285-293	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-47
17552754-8	2007	They also used these and other hydrogen-bond definitions to examine the dynamics of local hydrogen-bond number fluctuations, finding an approximate long-time decay constant for SPC/E water of between 0.8 and 0.9 ps, which corresponds to the time scale for local structural relaxation.	Hydrogen	90-98	proline rich protein gene cluster	Homo sapiens	177-180
17380484-16	2007	(J Mol Biol 2005; 353:1187-1198) that hydrogen bond networks couple motions across long distances in interleukin-1beta, lead us to hypothesize that the hydration of the cavity (conserved across mammals) can thermodynamically enhance hydrogen bond networks to enable coupling across long distances by acting as a plug and this in turn enables a kinetic control of the rate of transmission of signals.	Hydrogen	38-46	interleukin 1 beta	Homo sapiens	101-118
17380484-16	2007	(J Mol Biol 2005; 353:1187-1198) that hydrogen bond networks couple motions across long distances in interleukin-1beta, lead us to hypothesize that the hydration of the cavity (conserved across mammals) can thermodynamically enhance hydrogen bond networks to enable coupling across long distances by acting as a plug and this in turn enables a kinetic control of the rate of transmission of signals.	Hydrogen	233-241	interleukin 1 beta	Homo sapiens	101-118
17434532-4	2007	The five PLA2-bile salt complexes each result in a partly occluded active site, and the resulting ligand binding displays specific hydrogen bonding interactions and extensive hydrophobic packing.	Hydrogen	131-139	phospholipase A2 group IB	Homo sapiens	9-13
18019060-10	2007	hy926 cells were pretreated with different concentrations of JNK specific inhibitor SP 600125 (0, 10, 100 nmol/L and 1,10 micromol/L) 1h before hypoxic treatment of various duration, and the cell lysates were extracted to detect CASK expression with Western blot.	Hydrogen	134-136	mitogen-activated protein kinase 8	Homo sapiens	61-64
17439167-6	2007	Finally, our simulations reveal that water and TFE solvate the polypeptide in different ways: The hydrogen bond formation between TFE and Abeta was enhanced with decreasing temperature, while that between water and Abeta was depressed.	Hydrogen	98-106	amyloid beta precursor protein	Homo sapiens	138-143
17469804-9	2007	Taken together, the results indicate that D103 and S198 are involved in the binding and activation of BmOAR1 with OA through electrostatic or hydrogen bond interactions, but S202 does not appear to participate in this process.	Hydrogen	142-150	octopamine receptor	Bombyx mori	102-108
17552754-7	2007	These two definitions lead to an estimate of the number of hydrogen bonds per molecule in liquid simple point charge/extended (SPC/E) water of between 3.2 and 3.4.	Hydrogen	59-67	proline rich protein gene cluster	Homo sapiens	127-130
17552754-8	2007	They also used these and other hydrogen-bond definitions to examine the dynamics of local hydrogen-bond number fluctuations, finding an approximate long-time decay constant for SPC/E water of between 0.8 and 0.9 ps, which corresponds to the time scale for local structural relaxation.	Hydrogen	31-39	proline rich protein gene cluster	Homo sapiens	177-180
17439172-1	2007	Solution 1H NMR techniques were used to characterize the interaction of urea with poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers.	Hydrogen	9-11	protoporphyrinogen oxidase	Homo sapiens	151-154
17408268-2	2007	Wilkinson"s catalyst, RhCl(PPh3)3, supported on either modified silica gel or a polymer, is shown to hydrogenate styrene into ethylbenzene and to produce enhanced spin polarizations, observed through NMR, when the reaction was performed with H2 gas enriched in the para spin isomer.	Hydrogen	242-244	caveolin 1	Homo sapiens	27-31
17470694-10	2007	Phenotypes indirectly related to cyclooxygenase-1 were strongly and consistently heritable across races (h2=0.266 to 0.762; P&lt;0.01), but direct cyclooxygenase-1 phenotypes were not.	Hydrogen	105-107	prostaglandin-endoperoxide synthase 1	Homo sapiens	33-49
17444661-8	2007	TIM catalyzes proton transfer from glycolaldehyde in D2O, resulting in deuterium incorporation that can be monitored by 1H NMR spectroscopy, with kcat/Km = 0.26 M-1 s-1.	Hydrogen	120-122	triosephosphate isomerase 1	Homo sapiens	0-3
17418139-5	2007	In particular, the n-Src loop, highly flexible and partially disordered, is stabilized in an unusual conformation by the establishment of several intramolecular hydrogen bonds.	Hydrogen	161-169	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	21-24
17407325-1	2007	The X-ray crystal structures of human purine nucleoside phosphorylase (PNP) with bound inosine or transition-state analogues show His257 within hydrogen bonding distance of the 5"-hydroxyl.	Hydrogen	144-152	purine nucleoside phosphorylase	Homo sapiens	38-69
17407325-1	2007	The X-ray crystal structures of human purine nucleoside phosphorylase (PNP) with bound inosine or transition-state analogues show His257 within hydrogen bonding distance of the 5"-hydroxyl.	Hydrogen	144-152	purine nucleoside phosphorylase	Homo sapiens	71-74
17251021-3	2007	A hydrogen bond matrix involving the Pim-1 inhibitor, two water molecules, and the catalytic core, together with a potential weak hydrogen bond between an aromatic hydrogen on the R(1) phenyl ring and a main-chain carbonyl of Pim-1, accounts for the overall potency of this inhibitor.	Hydrogen	130-138	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	226-231
17274015-0	2007	A PM3/d specific reaction parameterization for iron atom in the hydrogen abstraction catalyzed by soybean lipoxygenase-1.	Hydrogen	64-72	seed linoleate 13S-lipoxygenase-1	Glycine max	106-120
17274015-1	2007	This paper reports a specific reaction parameter (SRP) PM3/d model for iron that can reproduce the DFT/MM results of the hydrogen abstraction reaction from the C11 position of linoleic acid by the Soybean lipoxygenase-1 enzyme.	Hydrogen	121-129	seed linoleate 13S-lipoxygenase-1	Glycine max	205-219
17388495-7	2007	As the solvent polarity increases, the polyproline II-like conformation becomes more populated and the relative stability of conformation tC with a C7 hydrogen bond between C"=O of the amino group and N-H of the carboxyl group decreases for both the Aze and Pip dipeptides, as seen for the Pro dipeptide.	Hydrogen	151-159	prolactin induced protein	Homo sapiens	258-261
17388495-10	2007	The pertinent distance d(N...H-N(NHMe)) and the pyramidality of imide nitrogen can describe the role of this hydrogen bond in stabilizing the transition state structure, but the lower rotational barriers for the Aze and Pip dipeptides than those for the Pro dipeptide, which is observed from experiments, cannot be rationalized.	Hydrogen	109-117	prolactin induced protein	Homo sapiens	220-223
17391058-8	2007	Structural alignment shows that Glu141 in TOP is likely to be hydrogen-bonded to Gln149, similar to the Glu143-Lys151 bond in Arabidopsis A2 peroxidase.	Hydrogen	62-70	peroxidase	Arabidopsis thaliana	141-151
17300943-0	2007	Actions between neonicotinoids and key residues of insect nAChR based on an ab initio quantum chemistry study: hydrogen bonding and cooperative pi-pi interaction.	Hydrogen	111-119	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	58-63
17335280-9	2007	Finally, the PDE activities of the ligand-bound forms for Asn84Val and Tyr126Phe mutants are significantly reduced as compared with that of WT, suggesting the importance of the hydrogen-bonding network from heme 6-propionate to Tyr126 through Asn84 in signal transmission.	Hydrogen	177-185	phosphodiesterase	Escherichia coli	13-16
17363026-6	2007	Complete NO3- reduction was possible without the accumulation of either NO2- or N2O when the H2 lumen pressure was increased to 17 psi and phosphate was added to the groundwater.	Hydrogen	93-95	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
17352496-9	2007	Together, the findings reported here support a model whereby the final conformational change accompanying CaM trapping buries little additional surface area but does involve formation of new hydrogen bonds and van der Waals contacts that contribute to formation of the high-affinity, CaM-trapped state.	Hydrogen	191-199	calmodulin 1	Homo sapiens	106-109
17407569-7	2007	Amide hydrogen-deuterium experiments on the free and p41-bound R21A Spc-SH3 domain indicate that binding elicits a strong reduction in the conformational flexibility of the domain.	Hydrogen	6-14	mitogen-activated protein kinase 1	Homo sapiens	53-56
17413217-0	2007	A new polymorph of a cobalt(III) Schiff base complex exhibits a one-dimensional C-H...O hydrogen-bonded extended structure with helical 2 1 symmetry.	Hydrogen	88-96	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	28-31
17413217-3	2007	The extended structure is a one-dimensional (aryl)C-H...O(carbonyl) hydrogen-bonded polymer with 2(1) (helical) symmetry and is thus distinct from the simple hydrogen-bonded stack of the P2(1)/n polymorph [Matsumoto, Imaizumi &amp; Ohyoshi (1983).	Hydrogen	68-76	cyclin dependent kinase inhibitor 1A	Homo sapiens	187-192
17413217-3	2007	The extended structure is a one-dimensional (aryl)C-H...O(carbonyl) hydrogen-bonded polymer with 2(1) (helical) symmetry and is thus distinct from the simple hydrogen-bonded stack of the P2(1)/n polymorph [Matsumoto, Imaizumi &amp; Ohyoshi (1983).	Hydrogen	158-166	cyclin dependent kinase inhibitor 1A	Homo sapiens	187-192
17218419-3	2007	Endothelin-1 (ET-1) is a potent vasoconstrictor that alters both sodium transport and hydrogen ion secretion in the kidney.	Hydrogen	86-94	endothelin 1	Rattus norvegicus	0-12
17218419-3	2007	Endothelin-1 (ET-1) is a potent vasoconstrictor that alters both sodium transport and hydrogen ion secretion in the kidney.	Hydrogen	86-94	endothelin 1	Rattus norvegicus	14-18
17292965-1	2007	It is well known that the wild type Cu,Zn superoxide dismutase (holo SOD) catalyzes the conversion of superoxide anion to peroxide hydrogen and dioxygen.	Hydrogen	131-139	superoxide dismutase 1	Homo sapiens	36-62
17292965-1	2007	It is well known that the wild type Cu,Zn superoxide dismutase (holo SOD) catalyzes the conversion of superoxide anion to peroxide hydrogen and dioxygen.	Hydrogen	131-139	superoxide dismutase 1	Homo sapiens	69-72
17332746-4	2007	Our data indicate that a TPN-assisted mechanism of peptide selection relies on disruption of conserved hydrogen bonds at the C-terminal end of the groove.	Hydrogen	103-111	TAP binding protein	Homo sapiens	25-28
17251021-3	2007	A hydrogen bond matrix involving the Pim-1 inhibitor, two water molecules, and the catalytic core, together with a potential weak hydrogen bond between an aromatic hydrogen on the R(1) phenyl ring and a main-chain carbonyl of Pim-1, accounts for the overall potency of this inhibitor.	Hydrogen	130-138	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	226-231
17370994-1	2007	The rates of formal abstraction of phenolic hydrogen atoms by free radicals, Y* + ArOH --&gt; YH + ArO*, are profoundly influenced by the hydrogen-bond-accepting and anion-solvation abilities of solvents, by the electron affinities and reactivities (Y-H bond dissociation enthalpies) of radicals, and by the phenol"s ring substituents.	Hydrogen	44-52	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	99-103
17315920-3	2007	A detailed electronic structure analysis leads to the presumption that the properties of the FeV=O bond can be modified by introducing substituents to the aromatic rings of TPA and thus the reactivity of HO-(TPA)FeV=O for the hydrogen atom abstraction of methane hydroxylation can be tuned on the quartet potential energy surface.	Hydrogen	226-234	plasminogen activator, tissue type	Homo sapiens	173-176
17315920-3	2007	A detailed electronic structure analysis leads to the presumption that the properties of the FeV=O bond can be modified by introducing substituents to the aromatic rings of TPA and thus the reactivity of HO-(TPA)FeV=O for the hydrogen atom abstraction of methane hydroxylation can be tuned on the quartet potential energy surface.	Hydrogen	226-234	plasminogen activator, tissue type	Homo sapiens	208-211
17370994-1	2007	The rates of formal abstraction of phenolic hydrogen atoms by free radicals, Y* + ArOH --&gt; YH + ArO*, are profoundly influenced by the hydrogen-bond-accepting and anion-solvation abilities of solvents, by the electron affinities and reactivities (Y-H bond dissociation enthalpies) of radicals, and by the phenol"s ring substituents.	Hydrogen	138-146	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	99-103
17327678-3	2007	The protonation of a hydrogen-bonded pair of lysines, Lys206 and Lys296, adjacent to the N-lobe iron site of Tf has been proposed to create a repulsive interaction that stimulates domain opening and iron release.	Hydrogen	21-29	transferrin	Homo sapiens	109-111
21783757-2	2007	The exposure of rats to SMF (128mT, 1h/day during 30 consecutive days) decreased the activities of glutathione peroxidase (GPx), catalase (CAT) and the superoxide dismutase (SOD) in liver and kidney.	Hydrogen	36-38	catalase	Rattus norvegicus	129-137
21783757-2	2007	The exposure of rats to SMF (128mT, 1h/day during 30 consecutive days) decreased the activities of glutathione peroxidase (GPx), catalase (CAT) and the superoxide dismutase (SOD) in liver and kidney.	Hydrogen	36-38	catalase	Rattus norvegicus	139-142
17328537-4	2007	Supplementing this deduction, critical interfeature distances between hydrogen bond acceptor, hydrophobic, and ring aromatic features along with steric influence are found to primarily influence the ER-subtypes specific binding of this series of compounds.	Hydrogen	70-78	estrogen receptor 1	Homo sapiens	199-201
17520827-2	2007	Based on the mechanism of action and the known structure-activity relationship of PARP-1 inhibitor, an optimal pharmacophore model including two hydrogen-bonding acceptors and two aromatic hydrophobic core was confirmed.	Hydrogen	145-153	poly(ADP-ribose) polymerase 1	Homo sapiens	82-88
17145042-5	2007	This response peaks at approximately 1h of stimulation with TNFalpha but sustained elevated levels of TNFalpha mRNA are observed for up to 24h after stimulation and are dependent on the presence of the soluble cytokine.	Hydrogen	37-39	tumor necrosis factor	Homo sapiens	60-68
17263515-8	2007	The minimum of T1(rho) assigned to the classical hopping of a hydrogen-bonded proton occurs in the same low-temperature regime in which the flattening of the temperature dependencies of T1 points to the dominance of incoherent tunneling.	Hydrogen	62-70	rhodopsin	Homo sapiens	15-22
17249656-3	2007	Addition of BH3.THF to (silox)3TaH2 provided the borohydride-hydride (silox)3HTa(eta3-BH4) (5), and its thermolysis released H2 to generate 2.	Hydrogen	33-35	hepatocellular carcinoma associated transcript 5	Homo sapiens	77-80
17266358-5	2007	The two hydrogen bonds between the catalyst and the SN2 transition state favor this pathway while just one strong hydrogen bond between the catalyst and the fluoride ion leads to a lower stabilization of the nucleophile, resulting in a higher reaction rate.	Hydrogen	8-16	solute carrier family 38 member 5	Homo sapiens	52-55
17266358-5	2007	The two hydrogen bonds between the catalyst and the SN2 transition state favor this pathway while just one strong hydrogen bond between the catalyst and the fluoride ion leads to a lower stabilization of the nucleophile, resulting in a higher reaction rate.	Hydrogen	114-122	solute carrier family 38 member 5	Homo sapiens	52-55
17194451-4	2007	The X-ray crystal structure of the ERK2/FR148083 complex revealed that the compound binds to the ATP binding site of ERK2, involving a covalent bond to Sgamma of ERK2 Cys166, hydrogen bonds with the backbone NH of Met108, Nzeta of Lys114, backbone C=O of Ser153, Ndelta2 of Asn154, and hydrophobic interactions with the side chains of Ile31, Val39, Ala52, and Leu156.	Hydrogen	175-183	mitogen-activated protein kinase 1	Homo sapiens	35-39
17194451-4	2007	The X-ray crystal structure of the ERK2/FR148083 complex revealed that the compound binds to the ATP binding site of ERK2, involving a covalent bond to Sgamma of ERK2 Cys166, hydrogen bonds with the backbone NH of Met108, Nzeta of Lys114, backbone C=O of Ser153, Ndelta2 of Asn154, and hydrophobic interactions with the side chains of Ile31, Val39, Ala52, and Leu156.	Hydrogen	175-183	mitogen-activated protein kinase 1	Homo sapiens	117-121
17194451-4	2007	The X-ray crystal structure of the ERK2/FR148083 complex revealed that the compound binds to the ATP binding site of ERK2, involving a covalent bond to Sgamma of ERK2 Cys166, hydrogen bonds with the backbone NH of Met108, Nzeta of Lys114, backbone C=O of Ser153, Ndelta2 of Asn154, and hydrophobic interactions with the side chains of Ile31, Val39, Ala52, and Leu156.	Hydrogen	175-183	mitogen-activated protein kinase 1	Homo sapiens	117-121
17187755-0	2007	Hydrogen-bond formation of the residue in H-loop of the nucleotide binding domain 2 with the ATP in this site and/or other residues of multidrug resistance protein MRP1 plays a crucial role during ATP-dependent solute transport.	Hydrogen	0-8	ATP binding cassette subfamily C member 1	Homo sapiens	164-168
17187755-4	2007	To partially address this question, we have mutated the histidine residue in H-loop of MRP1 to either a residue that prevents the formation of hydrogen-bonds with ATP and other residues in MRP1 or a residue that may potentially form these hydrogen-bonds.	Hydrogen	143-151	ATP binding cassette subfamily C member 1	Homo sapiens	87-91
17249765-1	2007	High-resolution electron spin resonance (ESR) spectra of radical pairs of a hydrogen atom that coupled with a methyl radical (H...CH3, H...CHD2, D...CH2D, and D...CD3) were observed for X-ray irradiated solid argon containing selectively deuterium-labeled methanes, CH4, CH2D2, and CD4, at 4.2 K. The double-quartet 1H-hyperfine (hf) splittings of ca.	Hydrogen	76-84	CD4 molecule	Homo sapiens	282-285
17187755-4	2007	To partially address this question, we have mutated the histidine residue in H-loop of MRP1 to either a residue that prevents the formation of hydrogen-bonds with ATP and other residues in MRP1 or a residue that may potentially form these hydrogen-bonds.	Hydrogen	239-247	ATP binding cassette subfamily C member 1	Homo sapiens	87-91
17253762-4	2007	The hydrogen bonding between the pyridine nitrogen and the hydroxyl groups of HEMA results in strong intrachain associations, prevents interactions between NREP and CA, and inhibits degradation of CA.	Hydrogen	4-12	neuronal regeneration related protein	Homo sapiens	156-160
17013614-5	2007	Cu(II) in the presence of Abeta has been reported to have a formal reduction potential of +0.72-0.77 V (vs. the standard hydrogen electrode).	Hydrogen	121-129	amyloid beta precursor protein	Homo sapiens	26-31
17269718-9	2007	The most critical Lys18 of BeKm-1 plugs its side chain into the channel selectivity filter, while the secondarily important Arg20 forms three hydrogen bonds with spatially neighboring residues in the hERG channel.	Hydrogen	142-150	ETS transcription factor ERG	Homo sapiens	200-204
17127070-3	2007	This strategy proved to be effective for the synthesis of ICE inhibitors, maintaining key hydrogen bond interactions with the enzyme and invoking a preferred conformation for binding.	Hydrogen	90-98	caspase 1	Homo sapiens	58-61
17249765-1	2007	High-resolution electron spin resonance (ESR) spectra of radical pairs of a hydrogen atom that coupled with a methyl radical (H...CH3, H...CHD2, D...CH2D, and D...CD3) were observed for X-ray irradiated solid argon containing selectively deuterium-labeled methanes, CH4, CH2D2, and CD4, at 4.2 K. The double-quartet 1H-hyperfine (hf) splittings of ca.	Hydrogen	316-318	CD4 molecule	Homo sapiens	282-285
17228934-1	2007	Essential to understanding the reaction dynamics of spin-orbit (SO) excited atomic chlorine (2P1/2) with molecular hydrogen is experimental measurements of the SO splitting of Cl in the van der Waals region of the entrance channel to reaction.	Hydrogen	115-123	NADH:ubiquinone oxidoreductase complex assembly factor 3	Homo sapiens	93-98
17385340-0	2007	Conformation of an octapeptide fragment (2-9) of kaliocin-1 in DMSO-d6 by 1H NMR and restrained molecular dynamics.	Hydrogen	74-76	lactotransferrin	Homo sapiens	49-59
17215371-3	2007	Based on quantum mechanics/molecular mechanics (QM/MM) calculations, the free energy for MeOH reduction of o-PQQ when MeOH is hydrogen bonded to Glu-171-CO(2)(-) and the crystal water (Wat1) is hydrogen bonded to Asp-297-CO(2)(-) is DeltaG++ = 11.7 kcal/mol, which is comparable with the experimental value of 8.5 kcal/mol.	Hydrogen	126-134	MTOR associated protein, LST8 homolog	Homo sapiens	185-189
17215371-3	2007	Based on quantum mechanics/molecular mechanics (QM/MM) calculations, the free energy for MeOH reduction of o-PQQ when MeOH is hydrogen bonded to Glu-171-CO(2)(-) and the crystal water (Wat1) is hydrogen bonded to Asp-297-CO(2)(-) is DeltaG++ = 11.7 kcal/mol, which is comparable with the experimental value of 8.5 kcal/mol.	Hydrogen	194-202	MTOR associated protein, LST8 homolog	Homo sapiens	185-189
17228934-2	2007	Here we report high-resolution direct absorption studies of the SO transition (2P1/2&lt;--2P3/2) of atomic chlorine isolated in solid molecular hydrogen (H2, HD, and D2).	Hydrogen	144-152	NADH:ubiquinone oxidoreductase complex assembly factor 3	Homo sapiens	79-84
17902085-0	2007	Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bonding.	Hydrogen	133-141	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	21-50
17279263-1	2007	A novel triptycene-based polymer of intrinsic microporosity (Trip-PIM) displays enhanced surface area (1065 m2 g(-1)) and reversibly adsorbs 1.65% hydrogen by mass at 1 bar/77 K and 2.71% at 10 bar/77 K.	Hydrogen	147-155	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	66-69
17124712-0	2007	Reactions of hydrogen atoms with met-enkephalin and related peptides.	Hydrogen	13-21	proopiomelanocortin	Homo sapiens	33-47
17173306-6	2007	This post-translational modification is predicted to alter the secondary structure in its surrounding and also to hinder the physiological bending of the central helix of CaM through an alteration of the hydrogen bond network established by the side chain of residue 81.	Hydrogen	204-212	calmodulin 1	Homo sapiens	171-174
17124712-3	2007	In Met-enkephalin (Tyr-Gly-Gly-Phe-Met) the attack of the hydrogen atom occurs to about 50 % on Met with formation of methanethiyl radical.	Hydrogen	58-66	proopiomelanocortin	Homo sapiens	3-17
17947986-2	2007	This "Mosher ester analysis" relies on the fact that the protons in diastereomeric alpha-methoxy-alpha-trifluoromethylphenylacetic acid (MTPA) esters (i.e., those derived from conjugation of the carbinol under interrogation with MTPA) display different arrays of chemical shifts (deltas) in their 1H NMR spectra.	Hydrogen	297-299	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	137-141
19169381-3	2007	Hydrogen bonds between water molecules in simulations are treated most frequently by using point charge water potentials, such as TIP3P or SPC, sometimes with a polarizable extension.	Hydrogen	0-8	proline rich protein gene cluster	Homo sapiens	139-142
17055616-4	2007	The results showed that all compounds act inside the AChE gorge, making pi-pi interactions and hydrogen bonds with Trp86 and Ser203 and by high HOMO energies of Ser2003 and high LUMO energies of N-aryl derivatives.	Hydrogen	95-103	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-57
18228682-7	2007	In some cases of chronic urticaria, the combination of H2 antihistamines may prove effective--though only with common liver metabolism (CYP3A4 isoenzyme-mediated) H1 antihistamines, due to the existence of mutual metabolic interferences.	Hydrogen	55-57	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	136-142
17048265-0	2007	1H, 13C and 15N NMR coordination shifts in gold(III), cobalt(III), rhodium(III) chloride complexes with pyridine, 2,2"-bipyridine and 1,10-phenanthroline.	Hydrogen	0-2	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	48-51
17048265-0	2007	1H, 13C and 15N NMR coordination shifts in gold(III), cobalt(III), rhodium(III) chloride complexes with pyridine, 2,2"-bipyridine and 1,10-phenanthroline.	Hydrogen	0-2	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	61-64
17048265-0	2007	1H, 13C and 15N NMR coordination shifts in gold(III), cobalt(III), rhodium(III) chloride complexes with pyridine, 2,2"-bipyridine and 1,10-phenanthroline.	Hydrogen	0-2	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	61-64
17218638-5	2007	Resolution of the crystal structure of PIM1 in complex with quercetagetin or two other flavonoids revealed a spectrum of binding poses and hydrogen-bonding patterns in spite of strong similarity of the ligands.	Hydrogen	139-147	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	39-43
17165784-0	2006	Photosensitized reduction of water to hydrogen using human serum albumin complexed with zinc-protoporphyrin IX.	Hydrogen	38-46	albumin	Homo sapiens	59-72
17008107-5	2007	Our data show that the phosphorylation of STAT5 was increased in hippocampal CA1 at 1h and 3h ischemia.	Hydrogen	84-86	signal transducer and activator of transcription 5A	Rattus norvegicus	42-47
17176086-8	2006	By measuring hydrogen/deuterium exchange with mass spectrometry we have shown that the formation of the CENP-E/AS-2 complex decreases the solvent accessibility of three neighboring peptides on the same face of CENP-E.	Hydrogen	13-21	centromere protein E	Homo sapiens	104-110
17176086-8	2006	By measuring hydrogen/deuterium exchange with mass spectrometry we have shown that the formation of the CENP-E/AS-2 complex decreases the solvent accessibility of three neighboring peptides on the same face of CENP-E.	Hydrogen	13-21	centromere protein E	Homo sapiens	210-216
17177427-2	2006	The carbopeptoid units form a beta-turn-type structure, stabilized by an intramolecular NH --&gt; O=C hydrogen bond across the sugar ring, thus forming a 10-membered, C10 turn.	Hydrogen	102-110	amyloid beta precursor protein	Homo sapiens	28-34
17177427-2	2006	The carbopeptoid units form a beta-turn-type structure, stabilized by an intramolecular NH --&gt; O=C hydrogen bond across the sugar ring, thus forming a 10-membered, C10 turn.	Hydrogen	102-110	homeobox C10	Homo sapiens	167-170
17165784-1	2006	We present the photophysical properties of complexes of recombinant human serum albumin (rHSA) with Zn(II)-protoporphyrin IX (ZnPP) and their activities in the photosensitized reduction of water to hydrogen (H2) using methyl viologen (MV2+) as an electron relay.	Hydrogen	198-206	albumin	Homo sapiens	74-87
17165784-1	2006	We present the photophysical properties of complexes of recombinant human serum albumin (rHSA) with Zn(II)-protoporphyrin IX (ZnPP) and their activities in the photosensitized reduction of water to hydrogen (H2) using methyl viologen (MV2+) as an electron relay.	Hydrogen	208-210	albumin	Homo sapiens	74-87
17046812-0	2006	Mapping ERK2-MKP3 binding interfaces by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	40-48	mitogen-activated protein kinase 1	Homo sapiens	8-12
17046812-3	2006	To understand the molecular basis of ERK2 recognition by MKP3, we carried out hydrogen/deuterium exchange mass spectrometry experiments to map the interaction surfaces between the two proteins.	Hydrogen	78-86	mitogen-activated protein kinase 1	Homo sapiens	37-41
17147452-5	2006	The purified corrinoid-compound was identified as pseudovitamin B12 (an inactive corrinoid-compound for humans) by silica gel 60 TLC, C18 reversed-phase HPLC, ultraviolet-visible spectroscopy, and 1H NMR spectroscopy.	Hydrogen	197-199	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	64-67
17049556-0	2006	Sequence dependence of BNIP3 transmembrane domain dimerization implicates side-chain hydrogen bonding and a tandem GxxxG motif in specific helix-helix interactions.	Hydrogen	85-93	BCL2 interacting protein 3	Homo sapiens	23-28
17132002-1	2006	Unusual reactions are reported, in which the aromatic PNP ligand (PNP = 2,6-bis-(di-tert-butylphosphinomethyl)pyridine) acts in concert with the metal in the activation of H2 and benzene, via facile aromatization/dearomatization processes of the ligand.	Hydrogen	172-174	purine nucleoside phosphorylase	Homo sapiens	54-57
17056012-7	2006	Model building studies on the human HIF prolyl hydroxylase 2 showed that the two phenolate oxygen atoms of gallate form a chelate with the active site Fe(2+), while the carboxyl group of gallate forms a strong ionic/hydrogen bonding interaction with Arg383, explaining why nPG, which has an esterified carboxyl group, is unable to inhibit the hydroxylase.	Hydrogen	216-224	egl-9 family hypoxia inducible factor 1	Homo sapiens	36-60
17132002-0	2006	Metal-ligand cooperation in C-H and H2 activation by an electron-rich PNP Ir(I) system: facile ligand dearomatization-aromatization as key steps.	Hydrogen	36-38	purine nucleoside phosphorylase	Homo sapiens	70-73
17132002-1	2006	Unusual reactions are reported, in which the aromatic PNP ligand (PNP = 2,6-bis-(di-tert-butylphosphinomethyl)pyridine) acts in concert with the metal in the activation of H2 and benzene, via facile aromatization/dearomatization processes of the ligand.	Hydrogen	172-174	purine nucleoside phosphorylase	Homo sapiens	66-69
17134234-0	2006	Enzyme dynamics and tunneling enhanced by compression in the hydrogen abstraction catalyzed by soybean lipoxygenase-1.	Hydrogen	61-69	seed linoleate 13S-lipoxygenase-1	Glycine max	103-117
17134234-1	2006	A fully microscopical simulation of the rate-limiting hydrogen abstraction catalyzed by soybean lipoxygenase-1 (SLO-1) has been carried out.	Hydrogen	54-62	seed linoleate 13S-lipoxygenase-1	Glycine max	96-110
17249194-10	2006	The results of 1H MRS for the subjects with susceptible genes ApoE epsilon3/epsilon4 (HRT group 12 cases, control group 11 cases) showed that the N-acetylaspartate/total creatine at the area of hippocampus in HRT group (1.54 +/- 0.08) were significantly higher than control group (1.45 +/- 0.13, P < 0.05).	Hydrogen	15-17	apolipoprotein E	Homo sapiens	62-66
17023150-5	2006	The subjects were exposed on each occasion for 1h during intermittent exercise at a ventilation of 40l min-1.	Hydrogen	47-49	CD59 molecule (CD59 blood group)	Homo sapiens	103-108
17069807-4	2006	PLD activity was increased at early time point (1h) whereas both PLD activity and PLD1 protein were strongly decreased after 24h.	Hydrogen	48-50	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
17125309-2	2006	On the basis of both HF and B3LYP methods, a well-defined first hydration shell of NO3- is obtainable, but the shell is quite flexible and the hydrogen-bond interactions between NO3- and water are rather weak.	Hydrogen	143-151	NBL1, DAN family BMP antagonist	Homo sapiens	178-181
17122853-0	2006	Watching hydrogen-bond dynamics in a beta-turn by transient two-dimensional infrared spectroscopy.	Hydrogen	9-17	amyloid beta precursor protein	Homo sapiens	35-41
17122853-6	2006	Here we show that the extension of this method into the non-equilibrium regime allows us to observe in real time in a short peptide the weakening of an intramolecular hydrogen bond and concomitant opening of a beta-turn.	Hydrogen	167-175	amyloid beta precursor protein	Homo sapiens	208-214
17091993-5	2006	This important physical insight is evidenced by comparison of the rates of the Pt-catalyzed formation of gold nanoparticles in the presence and in the absence of hydrogen (H(2)), which adsorb dissociatively on a Pt nanocrystal surface forming Pt-H species.	Hydrogen	162-170	parathyroid hormone	Homo sapiens	243-247
17091993-5	2006	This important physical insight is evidenced by comparison of the rates of the Pt-catalyzed formation of gold nanoparticles in the presence and in the absence of hydrogen (H(2)), which adsorb dissociatively on a Pt nanocrystal surface forming Pt-H species.	Hydrogen	172-176	parathyroid hormone	Homo sapiens	243-247
17073446-0	2006	Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3.	Hydrogen	20-28	caspase 3	Homo sapiens	74-83
16968701-0	2006	Functional importance of the interhelical hydrogen bond between Thr204 and Tyr174 of sensory rhodopsin II and its alteration during the signaling process.	Hydrogen	42-50	rhodopsin	Homo sapiens	93-102
17061855-4	2006	The UG unit presents an ADDA hydrogen bonding array that is complementary to the DAAD array of DAN, and these form a very strong complex (Kassoc approximately 5 x 107 M-1), whereas UG and DAN weakly self-associate.	Hydrogen	29-37	adducin 1	Homo sapiens	24-28
16916893-12	2006	Pressor responses to HS were larger in SAP rats than in sham rats (17 +/- 5 versus 9 +/- 2 mmHg, at 20 min), whereas during VE these responses were similar in both groups (6 +/- 3 versus 4 +/- 6 mmHg, at 20 min).	Hydrogen	21-23	amyloid P component, serum	Rattus norvegicus	39-42
26627024-5	2006	For van der Waals and hydrogen bonded complexes, the linearization of[Formula: see text] [rhoA,rhoB] affects negligibly the calculated properties.	Hydrogen	22-30	ras homolog family member A	Homo sapiens	90-94
16868074-0	2006	A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome.	Hydrogen	11-13	peroxisome proliferator activated receptor alpha	Mus musculus	85-95
17034250-6	2006	The case of thrombin, an allosteric enzyme incorporating a network of 20 internal hydrogen bonded water molecules, is discussed.	Hydrogen	82-90	coagulation factor II, thrombin	Homo sapiens	12-20
16954157-11	2006	In addition, GIP reduced the amplitude of transient and sustained potassium currents in H2.	Hydrogen	88-90	gastric inhibitory polypeptide	Homo sapiens	13-16
17092067-0	2006	Inelastic scattering matrix elements for the nonadiabatic collision B(2P1/2)+H2(1Sigmag+,j)&lt;--&gt;B(2P3/2)+H2(1Sigmag+,j").	Hydrogen	77-79	NADH:ubiquinone oxidoreductase complex assembly factor 3	Homo sapiens	70-75
17015824-5	2006	Structural modeling suggests that the enhanced ability of Envs with N283 to use low levels of CD4 is due to a hydrogen bond formed with Gln 40 of CD4.	Hydrogen	110-118	CD4 molecule	Homo sapiens	94-97
17015824-5	2006	Structural modeling suggests that the enhanced ability of Envs with N283 to use low levels of CD4 is due to a hydrogen bond formed with Gln 40 of CD4.	Hydrogen	110-118	CD4 molecule	Homo sapiens	146-149
17004712-14	2006	Taken together, these results support the hypothesis that it is the carboxamide oxygen of the C-3 substituent of 1 that engages in a hydrogen bond with K3.28(192) in WT CB1.	Hydrogen	133-141	cannabinoid receptor 1	Homo sapiens	169-172
16926162-4	2006	P-gp-drug substrate interactions likely involve hydrogen bonds.	Hydrogen	48-56	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
16926162-6	2006	We predicted that an arginine residue in the TM segments predicted to line the drug-binding pocket of P-gp (I306(TM5) or F343(TM6)) might suppress DeltaY490 P-gp protein misfolding because it has the highest propensity to form hydrogen bonds.	Hydrogen	227-235	ATP binding cassette subfamily B member 1	Homo sapiens	102-106
17025370-0	2006	1H NMR investigation of thermally triggered insulin release from poly(N-isopropylacrylamide) microgels.	Hydrogen	0-2	insulin	Homo sapiens	44-51
16926162-6	2006	We predicted that an arginine residue in the TM segments predicted to line the drug-binding pocket of P-gp (I306(TM5) or F343(TM6)) might suppress DeltaY490 P-gp protein misfolding because it has the highest propensity to form hydrogen bonds.	Hydrogen	227-235	ATP binding cassette subfamily B member 1	Homo sapiens	157-161
16844746-6	2006	Activation of the slow process is responsible for the dynamical transition at T approximately 200 K. The dependence of the slow process on hydration correlates with the hydration dependence of the enzymatic activity of lysozyme, whereas the dependence of the fast process seems to correlate with the hydration dependence of hydrogen exchange of lysozyme.	Hydrogen	324-332	lysozyme	Homo sapiens	219-227
16844746-6	2006	Activation of the slow process is responsible for the dynamical transition at T approximately 200 K. The dependence of the slow process on hydration correlates with the hydration dependence of the enzymatic activity of lysozyme, whereas the dependence of the fast process seems to correlate with the hydration dependence of hydrogen exchange of lysozyme.	Hydrogen	324-332	lysozyme	Homo sapiens	345-353
16876149-8	2006	Molecular modeling of hKv1.5 channel structure suggests that S-nitrosylation of Cys331 (segment 2, S2) and Cys346 (S2) would be stabilized by hydrogen bridge bonds with Ile262 (S1) and Arg342 (S2), respectively.	Hydrogen	142-150	potassium voltage-gated channel subfamily A member 5	Homo sapiens	22-28
16946699-4	2006	The structures reveal that WDR5 is able to bind all of these histone H3 peptides, but only H3K4me2 peptide forms extra interactions with WDR5 by use of both water-mediated hydrogen bonding and the altered hydrophilicity of the modified lysine 4.	Hydrogen	172-180	WD repeat domain 5	Homo sapiens	27-31
16982895-5	2006	A specific hydrogen-bonding network between PIM2 and CD1d orients the headgroup in the center of the binding groove and above the A" pocket.	Hydrogen	11-19	CD1d1 antigen	Mus musculus	53-57
17121353-2	2006	It has been shown that there are hydrogen bond because of -NH at the interfaces of HSA-DLC, HFG-DF and HFG-graphite.	Hydrogen	33-41	albumin	Homo sapiens	83-86
16946699-4	2006	The structures reveal that WDR5 is able to bind all of these histone H3 peptides, but only H3K4me2 peptide forms extra interactions with WDR5 by use of both water-mediated hydrogen bonding and the altered hydrophilicity of the modified lysine 4.	Hydrogen	172-180	WD repeat domain 5	Homo sapiens	137-141
16970375-0	2006	Theoretical investigation of hydrogen bonds between CO and HNF2, H2NF, and HNO.	Hydrogen	29-37	HNF1 homeobox B	Homo sapiens	59-63
16615111-10	2006	Besides His6, His13, and His14, Tyr10 is also involved in the coordination of Abeta(1-16) with Cu2+, which is supported by 1H NMR and UV-visible absorption spectra.	Hydrogen	123-125	amyloid beta precursor protein	Homo sapiens	78-83
16970375-1	2006	Ab initio quantum mechanics methods were applied to investigate the hydrogen bonds between CO and HNF2, H2NF, and HNO.	Hydrogen	68-76	HNF1 homeobox B	Homo sapiens	98-102
16970376-0	2006	Competition between nonclassical hydrogen-bonded acceptor sites in complexes of neutral AH2 Radicals (A = B, Al, and Ga): A theoretical investigation.	Hydrogen	33-41	zinc finger RANBP2-type containing 3	Homo sapiens	88-91
16970376-1	2006	An ab initio computational study of the properties of the neutral AH2 radicals (A = B, Al, Ga) as hydrogen-bond (HB) acceptors, with H-X (X = F, Cl, Br, CN, and CCH) as HB donors, is carried out at the UMP2/6-311++G(2d,2p) level.	Hydrogen	98-106	zinc finger RANBP2-type containing 3	Homo sapiens	66-69
16970376-4	2006	The second corresponds to a dihydrogen bond complex between one of the hydrogen atoms of AH2 and the H-X molecule.	Hydrogen	28-38	zinc finger RANBP2-type containing 3	Homo sapiens	89-92
16970376-4	2006	The second corresponds to a dihydrogen bond complex between one of the hydrogen atoms of AH2 and the H-X molecule.	Hydrogen	30-38	zinc finger RANBP2-type containing 3	Homo sapiens	89-92
16939282-2	2006	A urea of guanosine (1, UG) and 2,7-diamido-1,8-naphthyridine (2, DAN), which form an exceptionally strong quadruply hydrogen-bonding complex, are displayed at 1-10 mol % along the main backbone of PBMA and PS, respectively.	Hydrogen	117-125	NBL1, DAN family BMP antagonist	Homo sapiens	66-69
16622654-0	2006	Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase-inhibitor complex.	Hydrogen	14-22	aldo-keto reductase family 1 member B	Homo sapiens	87-103
16766615-5	2006	The hairpin is stabilized by backbone hydrogen-bonding interactions between residues K28 and I31; S26 and G33; and by side-chain-to-side-chain interactions between N27 and I32.	Hydrogen	38-46	keratin 28	Homo sapiens	85-88
16538665-4	2006	Here we describe structural and stability properties of PS2.M alone in different buffers and metal ions, using gel electrophoresis, circular dichroism (CD), ultraviolet (UV)-visible spectroscopies, and one-dimensional 1H nuclear magnetic resonance (NMR).	Hydrogen	218-220	taste 2 receptor member 64 pseudogene	Homo sapiens	56-59
16923067-1	2006	The effect of deleting the genes encoding the twin-arginine translocation (Tat) system on H2 production by Escherichia coli strain MC4100 and its formate hydrogenlyase upregulated mutant (DeltahycA) was investigated.	Hydrogen	90-92	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	75-78
16923067-2	2006	H2 evolution tests using two mutant strains defective in Tat transport (DeltatatC and DeltatatA-E) showed that the rate doubled from 0.88+/-0.28 mL H2 mg dry weight-1 L culture-1 in the parental strain, to 1.70+/-0.15 and 1.75+/-0.18 mL H2 mg dry weight-1 L culture-1, respectively, in the DeltatatC and DeltatatA-E strains.	Hydrogen	0-2	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	57-60
16923067-2	2006	H2 evolution tests using two mutant strains defective in Tat transport (DeltatatC and DeltatatA-E) showed that the rate doubled from 0.88+/-0.28 mL H2 mg dry weight-1 L culture-1 in the parental strain, to 1.70+/-0.15 and 1.75+/-0.18 mL H2 mg dry weight-1 L culture-1, respectively, in the DeltatatC and DeltatatA-E strains.	Hydrogen	148-150	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	57-60
16923067-2	2006	H2 evolution tests using two mutant strains defective in Tat transport (DeltatatC and DeltatatA-E) showed that the rate doubled from 0.88+/-0.28 mL H2 mg dry weight-1 L culture-1 in the parental strain, to 1.70+/-0.15 and 1.75+/-0.18 mL H2 mg dry weight-1 L culture-1, respectively, in the DeltatatC and DeltatatA-E strains.	Hydrogen	148-150	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	57-60
16923067-5	2006	Inactivation of the Tat system prevents correct assembly of the uptake hydrogenases and formate dehydrogenases in the cytoplasmic membrane and it is postulated that the subsequent loss of basal levels of respiratory-linked hydrogen and formate oxidation accounts for the observed increases in formate-dependent hydrogen evolution.	Hydrogen	71-79	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	20-23
16923067-5	2006	Inactivation of the Tat system prevents correct assembly of the uptake hydrogenases and formate dehydrogenases in the cytoplasmic membrane and it is postulated that the subsequent loss of basal levels of respiratory-linked hydrogen and formate oxidation accounts for the observed increases in formate-dependent hydrogen evolution.	Hydrogen	98-106	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	20-23
16898767-9	2006	These CT interactions occurred through the hydrogen-bond networks between the ER and EST.	Hydrogen	43-51	estrogen receptor 1	Homo sapiens	78-80
16923067-0	2006	Inactivation of the Escherichia coli K-12 twin-arginine translocation system promotes increased hydrogen production.	Hydrogen	96-104	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	42-69
16923067-1	2006	The effect of deleting the genes encoding the twin-arginine translocation (Tat) system on H2 production by Escherichia coli strain MC4100 and its formate hydrogenlyase upregulated mutant (DeltahycA) was investigated.	Hydrogen	90-92	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	46-73
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Hydrogen	169-177	lactoperoxidase	Homo sapiens	485-488
16873119-1	2006	Dihydrofolate reductase (DHFR) maintains the intracellular pool of tetrahydrofolate through catalysis of hydrogen transfer from reduced nicotinamide adenine dinucleotide to 7,8-dihydrofolate.	Hydrogen	105-113	dihydrofolate reductase	Escherichia coli	25-29
16873119-3	2006	We propose an evolutionary pattern in which catalysis progressed from a relatively rigid active site structure in the ancient thermophilic DHFR to a more flexible and kinetically more efficient structure in E. coli that actively promotes hydrogen transfer at physiological pH by modulating the tunnelling distance.	Hydrogen	238-246	dihydrofolate reductase	Escherichia coli	139-143
16873119-5	2006	The reduced hydrogen transfer rates of the extensively studied Gly121Val mutant of DHFR from E. coli were most likely due to sterically unfavourable long-range effects from the introduction of the bulky isopropyl group.	Hydrogen	12-20	dihydrofolate reductase	Escherichia coli	83-87
16784849-2	2006	Compound 1b (relative binding affinity, RBA = 6.4) and 1h (RBA = 12.6) showed higher binding affinity than flutamide (RBA = 1), a potent AR antagonist.	Hydrogen	55-57	androgen receptor	Homo sapiens	137-139
16784849-4	2006	The derivatives were also tested for their activities against another nuclear receptor, farnesoid x receptor (FXR), with most compounds acting as weak antagonists, however, compound 1h behaved as a FXR agonist with activity slightly less than that of chenodeoxycholic acid (CDCA), a natural FXR agonist.	Hydrogen	182-184	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	98-108
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Hydrogen	169-177	lactoperoxidase	Homo sapiens	500-503
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Hydrogen	199-207	lactoperoxidase	Homo sapiens	485-488
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Hydrogen	199-207	lactoperoxidase	Homo sapiens	500-503
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Hydrogen	199-207	lactoperoxidase	Homo sapiens	485-488
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Hydrogen	199-207	lactoperoxidase	Homo sapiens	500-503
16884312-1	2006	N-Me-anthranylaldoximes possess a hydrogen-bonded pseudocyclic A" ring in place of the typical phenolic A-ring that is characteristic of most estrogen receptor (ER) ligands.	Hydrogen	34-42	estrogen receptor 1	Homo sapiens	142-159
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Hydrogen	199-207	lactoperoxidase	Homo sapiens	485-488
16884312-1	2006	N-Me-anthranylaldoximes possess a hydrogen-bonded pseudocyclic A" ring in place of the typical phenolic A-ring that is characteristic of most estrogen receptor (ER) ligands.	Hydrogen	34-42	estrogen receptor 1	Homo sapiens	161-163
16942290-4	2006	The model has the following characters: (1)it allows the charges in system to fluctuate responding to the ambient environment; (2) for two major types of intermolecular hydrogen bonds, which are the hydrogen bond forming between the lone-pair electron on amide oxygen and the water hydrogen, and the one forming between the lone-pair electron on water oxygen and the amide hydrogen, we take special treatments in describing the electrostatic interaction by the use of the parameters k(lpO=, H) and k(lpO(-), HN(-)), respectively.	Hydrogen	199-207	lactoperoxidase	Homo sapiens	500-503
16678324-9	2006	Two apoptotic critical factors-lowering of the mitochondrial transmembrane potential (DeltaPsim) and activation of caspase 3/7-were significantly increased after 1h of sevoflurane treatment.	Hydrogen	162-164	caspase 3	Homo sapiens	115-124
16888629-4	2006	The beta-turn region fits into a binding pocket on the top face of the Kelch domain and the glutamate residues form multiple hydrogen bonds with highly conserved residues in Keap1.	Hydrogen	125-133	kelch like ECH associated protein 1	Homo sapiens	174-179
16866351-6	2006	A favorable network of hydrogen bonds involving the oxyanion hole, catalytic histidine, and the atoms in the prime site of the inhibitor enhance the binding affinity and specificity of the aza-peptide epoxide inhibitors toward caspase-3.	Hydrogen	23-31	caspase 3	Homo sapiens	227-236
16848423-5	2006	The present NMR studies utilized uniformly 15N-labeled Abeta(1-40) peptide and 1H-15N HSQC experiments and demonstrate for the first time that the Abeta binds Cu and Zn in a distinct manner.	Hydrogen	79-81	amyloid beta precursor protein	Homo sapiens	147-152
16823031-0	2006	Hydrogen/deuterium-exchange (H/D-Ex) of PPARgamma LBD in the presence of various modulators.	Hydrogen	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	40-49
16823031-3	2006	Amide hydrogen/deuterium-exchange (H/D-Ex), coupled with proteolysis and mass spectrometry, was applied to study the dynamics of the PPARgamma ligand binding domain (LBD) with or without molecules that modulate PPARgamma activity.	Hydrogen	6-14	peroxisome proliferator activated receptor gamma	Homo sapiens	133-142
16942189-11	2006	Such results can be explained by the smaller degree of hydrogen bonds formed by longer chain molecules of PPG at ambient pressure than that created by shorter chains of PPG at high pressure.	Hydrogen	55-63	serglycin	Homo sapiens	106-109
16942189-11	2006	Such results can be explained by the smaller degree of hydrogen bonds formed by longer chain molecules of PPG at ambient pressure than that created by shorter chains of PPG at high pressure.	Hydrogen	55-63	serglycin	Homo sapiens	169-172
16600620-3	2006	Thermodynamic parameters for the binding indicated that hydrogen bonding interactions are predominantly involved in the binding of these drugs to human serum albumin.	Hydrogen	56-64	albumin	Homo sapiens	152-165
16848423-7	2006	NMR titration experiments showed that the amide NH peak intensities of R5-L17 showed the most pronounced intensity reduction, and that the 1H signals for the side chain aromatic signals of the three histidines shift upfield (H6, H13, and H14).	Hydrogen	139-141	H1.3 linker histone, cluster member	Homo sapiens	229-232
16848484-4	2006	Both the experimental and the theoretical results demonstrate that sn-1 carbonyl has a higher propensity to form hydrogen bonds with water in comparison to sn-2.	Hydrogen	113-121	solute carrier family 38 member 3	Homo sapiens	67-71
16545833-6	2006	1H NMR chemical shift of PO -CH2- and -CH3 signals shows a larger decrease in ppm values than that of EO -CH2- signal with the increase of PPO/PEO ratio or temperature indicating that PO segments exist in a more hydrophobic microenvironment.	Hydrogen	0-2	protoporphyrinogen oxidase	Homo sapiens	139-142
16836319-9	2006	The Cs2(H(2)O)(5) clusters are connected through weak Ow5...Ow5" hydrogen bonds (2.88 A) and form polymeric chains in the straight channel direction (010).	Hydrogen	65-73	chorionic somatomammotropin hormone 2	Homo sapiens	4-7
16834322-2	2006	Here, hydrogen/deuterium exchange mass spectrometry (H/D-Ex) was employed to assess the role of dynamics for a high-affinity human growth hormone variant (hGHv) and the wild-type growth hormone (wt-hGH) each binding to the extracellular domain of their receptor (hGHbp).	Hydrogen	6-14	growth hormone 1	Homo sapiens	131-145
16784750-9	2006	Only after the backbone hydrogen bonds are formed between beta1 and beta2 does a hydrogen bond form to stabilize the intervening turn, or the first beta-turn.	Hydrogen	24-32	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	58-63
16784750-9	2006	Only after the backbone hydrogen bonds are formed between beta1 and beta2 does a hydrogen bond form to stabilize the intervening turn, or the first beta-turn.	Hydrogen	81-89	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	58-63
16414257-5	2006	The electric-field-induced increase in the activation barrier of proton-transfer steps attributed to the rearrangement of the hydrogen bond network and the self-aggregation of cyt c upon adsorption on DNA-modified electrode strongly decrease the interfacial electron transfer rate.	Hydrogen	126-134	cytochrome c, somatic	Homo sapiens	176-181
16545833-8	2006	The breakdown of this intra-molecular hydrogen bond may result in a decrease of gauche conformers of the PPO chain.	Hydrogen	38-46	protoporphyrinogen oxidase	Homo sapiens	105-108
16819831-5	2006	We have determined that the association between the FMRP RGG box and Sc1 RNA is dominated by hydrophobic and hydrogen bond interactions, with minor contributions from electrostatic interactions, and that the FMRP RGG box binding increases the stability of the G quartet RNA structure significantly.	Hydrogen	109-117	fragile X messenger ribonucleoprotein 1	Homo sapiens	52-56
16821883-8	2006	It was shown that the interaction with THC or the THC-ApoA-I complex leads to the formation of hydrogen bonds between the OH group of the hormone A-ring and the C=O group of cytosine or guanine.	Hydrogen	95-103	apolipoprotein A1	Homo sapiens	54-60
16821883-9	2006	Interaction with cortisol or the cortisol-ApoA-I complex leads to the formation of a hydrogen bond with the NH group of cytosine; in addition, THC and cortisol form hydrogen bonds with the PO2 group of the duplex and with the OH group of the monosaccharide.	Hydrogen	85-93	apolipoprotein A1	Homo sapiens	42-48
16821883-9	2006	Interaction with cortisol or the cortisol-ApoA-I complex leads to the formation of a hydrogen bond with the NH group of cytosine; in addition, THC and cortisol form hydrogen bonds with the PO2 group of the duplex and with the OH group of the monosaccharide.	Hydrogen	165-173	apolipoprotein A1	Homo sapiens	42-48
16821883-10	2006	The interaction of ApoA-I with the duplex is accompanied by the formation of hydrogen bonds between the protein NH2 group and the C=O group of cytosine and the P=O group.	Hydrogen	77-85	apolipoprotein A1	Homo sapiens	19-25
16821837-1	2006	Products of the reaction of C(60) with H(2) gas have been monitored by high-resolution atmospheric pressure photoionization Fourier transform ion cyclotron resonance mass spectrometry (APPI FT-ICR MS), X-ray diffraction, and IR spectroscopy as a function of hydrogenation period.	Hydrogen	39-43	amyloid beta precursor protein	Homo sapiens	185-189
16453305-4	2006	For phthalimides, the solvent isotope effect on the S(1)-state energy conversion, when hydrogen is replaced by deuterium in the OH groups of alcohols and water, has been analyzed.	Hydrogen	87-95	proteasome 26S subunit, non-ATPase 1	Homo sapiens	52-56
16453305-5	2006	Based on the data for fluorescence quenching in solvents of different polarity, the dipole moments in the intermolecular charge transfer S(1) state have been obtained for carotenoids (peridinin, fucoxanthin, uriolide acetate) and for hydrogen-bonding complexes, which are formed by 4-amino-, 4-methylamino-, and 4-dimethylamino-N-methylphthalimides in alcohols and water.	Hydrogen	234-242	proteasome 26S subunit, non-ATPase 1	Homo sapiens	137-141
17965616-6	2006	DNA hypermethylation of TDG in the MM cell lines leads to lower gene expression levels that results in less efficient DNA repair activity in response to hydrogen peroxideinduced DNA damage.	Hydrogen	153-161	thymine DNA glycosylase	Homo sapiens	24-27
16632356-4	2006	X-ray co-crystallization studies with mutated p38alpha showed that these trisubstituted ureas interact with the ATP-binding pocket in a pseudo-bicyclic conformation brought about by the presence of an intramolecular hydrogen bonding interaction.	Hydrogen	216-224	mitogen-activated protein kinase 14	Homo sapiens	46-54
16807147-4	2006	The native SLPI has no hydrophobic core and contains very little hydrogen bonded secondary structure [Gruetter, M., Fendrich, G., Huber, R., and Bode, W. (1988) The 2.5 A X-ray crystal structure of the acid stable proteinase inhibitor from human mucous secretions analyzed in its complex with bovine alpha-chymotrypsin.	Hydrogen	65-73	secretory leukocyte peptidase inhibitor	Homo sapiens	11-15
16862447-4	2006	Both theoretical and experimental data show that the GC pair has a binding energy (-25.4 kcal mol(-1) at the MP2/6-31G** level) twice that of the AT (-12.4 kcal mol(-1)) and H-AT (-12.8 kcal mol(-1)) pairs, compared with three conventional N-H...O(N) hydrogen bonds in the GC pair and two in the AT or H-AT pair.	Hydrogen	251-259	major intrinsic protein of lens fiber	Homo sapiens	109-114
16859309-2	2006	The crystal structure of stromelysin-1 (MMP-3) was used to pinpoint areas on the ligands and receptors where steric and electrostatic effects (for CoMFA) and steric, electrostatic, hydrogen-bond donor, hydrogen-bond acceptor, and hydrophobic effects (for CoMSIA) correlate with an increase or decrease in experimental biological activity.	Hydrogen	202-210	matrix metallopeptidase 3	Homo sapiens	25-38
17106765-8	2006	Based upon these results, we propose that the formation of this hydrogen bonded AEA/TMH6 complex may be the initial step in CB1 recognition of AEA in the lipid bilayer.	Hydrogen	64-72	cannabinoid receptor 1	Homo sapiens	124-127
16690080-1	2006	Previous work used hydrogen exchange (HX) experiments in kinetic and equilibrium modes to study the reversible unfolding and refolding of cytochrome c (Cyt c) under native conditions.	Hydrogen	19-27	cytochrome c, somatic	Homo sapiens	138-150
16767761-1	2006	1H MR spectroscopy (MRS) has proved to be a valuable noninvasive tool to measure intramyocellular lipids (IMCL) in research focused on insulin resistance and type II diabetes in both humans and rodents.	Hydrogen	0-2	insulin	Homo sapiens	135-142
16644738-1	2006	Hydrogen exchange monitored by mass spectrometry has been used to study the structural behavior of the pathogenic A4V variant of superoxide dismutase 1 (SOD1) in the metal-free (apo) form.	Hydrogen	0-8	superoxide dismutase 1	Homo sapiens	129-151
16644738-1	2006	Hydrogen exchange monitored by mass spectrometry has been used to study the structural behavior of the pathogenic A4V variant of superoxide dismutase 1 (SOD1) in the metal-free (apo) form.	Hydrogen	0-8	superoxide dismutase 1	Homo sapiens	153-157
16819715-7	2006	The hydrogen bonds, the root mean square deviations and specific radial distribution functions were employed to identify changes in the hydrogen bond structures, in the stability and in the approximation of groups in the different peptides to get some insight into the biological role of specific bFGF regions.	Hydrogen	136-144	fibroblast growth factor 2	Homo sapiens	297-301
16819715-8	2006	The detailed description of the intramolecular hydrogen bonds, hydration, and intermolecular hydrogen bonds taking place in bFGF and its mutants in the presence of ethanol established that the residues belonging to the beta5 and beta9 strands, especially SER-73(beta5), TYR-112(beta9), THR-114(beta9), TYR-115(beta9), and SER-117(beta9), are the regions most affected by the presence of ethanol molecules in solution.	Hydrogen	47-55	fibroblast growth factor 2	Homo sapiens	124-128
16819715-8	2006	The detailed description of the intramolecular hydrogen bonds, hydration, and intermolecular hydrogen bonds taking place in bFGF and its mutants in the presence of ethanol established that the residues belonging to the beta5 and beta9 strands, especially SER-73(beta5), TYR-112(beta9), THR-114(beta9), TYR-115(beta9), and SER-117(beta9), are the regions most affected by the presence of ethanol molecules in solution.	Hydrogen	93-101	fibroblast growth factor 2	Homo sapiens	124-128
16771488-4	2006	Hydrogen evolves slowly at room temperature and is accelerated upon sample heating, with a first increase in hydrogen evolution occurring at approximately 60 degrees C. Subsequent chemical modification leads to the observation of crystalline carbons, including nanocrystalline diamond surrounded by graphene ribbons, other sp2-sp3 transition regions, purely graphitic regions, and a previously unidentified crystalline carbon form surrounded by amorphous carbon.	Hydrogen	0-8	Sp2 transcription factor	Homo sapiens	323-326
16690080-1	2006	Previous work used hydrogen exchange (HX) experiments in kinetic and equilibrium modes to study the reversible unfolding and refolding of cytochrome c (Cyt c) under native conditions.	Hydrogen	19-27	cytochrome c, somatic	Homo sapiens	152-157
16771488-4	2006	Hydrogen evolves slowly at room temperature and is accelerated upon sample heating, with a first increase in hydrogen evolution occurring at approximately 60 degrees C. Subsequent chemical modification leads to the observation of crystalline carbons, including nanocrystalline diamond surrounded by graphene ribbons, other sp2-sp3 transition regions, purely graphitic regions, and a previously unidentified crystalline carbon form surrounded by amorphous carbon.	Hydrogen	0-8	Sp3 transcription factor	Homo sapiens	327-330
16759101-4	2006	The molecular modeling studies showed that BPR makes a strong network of hydrogen bonds with the DNA-binding region of the p50 subunit of NF-kappaB and has electronegative potential on its peripheral surface.	Hydrogen	73-81	nuclear factor kappa B subunit 1	Homo sapiens	138-147
16769893-7	2006	Furthermore, the ET rate from NADPH/CPR to the composite is 3.5-fold faster than that of Fe(Schiff-base).HO, although the redox potential of Fe(10-CH(2)CH(2)COOH-Schiff-base).HO (-79 mV vs. NHE) is lower than that of Fe(Schiff-base).HO (+15 mV vs. NHE), where NHE is normal hydrogen electrode.	Hydrogen	274-282	cytochrome p450 oxidoreductase	Homo sapiens	36-39
16639747-8	2006	The C-terminal carboxylate of DCEG glutathione"s glycine formed hydrogen bonds to Leu301 and Ser302, while the remaining interactions between DCEG and AR were hydrophobic, permitting significant flexibility of the AR and glutathione (GS) analogue interaction.	Hydrogen	64-72	aldo-keto reductase family 1 member B	Homo sapiens	151-153
16768499-6	2006	The counteranions, such as NO3- were found to interact strongly with surface silanols through multiple hydrogen bonds but have limited effect on the adsorption energy of olefins on the Ag+ cations.	Hydrogen	103-111	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
16731963-6	2006	This bend is stabilized by a network of hydrogen bonds involving the side chain of residue D23 and the amide hydrogens of adjacent residues G25, S26, N27, and K28, as well as by a salt bridge formed between side chains of K28 and E22.	Hydrogen	40-48	keratin 28	Homo sapiens	159-162
16613723-7	2006	Results indicate that steric, electrostatic, hydrophobic (lipophilic) and hydrogen bond donor substituents play a significant role in COX-2 inhibitory activity and selectivity of the compounds.	Hydrogen	74-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	134-139
16724983-6	2006	A total of 5.0 and 10 micromol/L hydrogen peroxide (H(2)O(2)) caused cell death in a dose-dependent manner after 24 h. On western blot analysis at 1 h with H(2)O(2), rapid phosphorylation of both ERK1/2 and c-Jun NH(2)-terminal kinase (JNK) was observed.	Hydrogen	52-56	mitogen-activated protein kinase 3	Homo sapiens	196-202
16724983-6	2006	A total of 5.0 and 10 micromol/L hydrogen peroxide (H(2)O(2)) caused cell death in a dose-dependent manner after 24 h. On western blot analysis at 1 h with H(2)O(2), rapid phosphorylation of both ERK1/2 and c-Jun NH(2)-terminal kinase (JNK) was observed.	Hydrogen	52-56	mitogen-activated protein kinase 8	Homo sapiens	207-234
16724983-6	2006	A total of 5.0 and 10 micromol/L hydrogen peroxide (H(2)O(2)) caused cell death in a dose-dependent manner after 24 h. On western blot analysis at 1 h with H(2)O(2), rapid phosphorylation of both ERK1/2 and c-Jun NH(2)-terminal kinase (JNK) was observed.	Hydrogen	52-56	mitogen-activated protein kinase 8	Homo sapiens	236-239
16732655-9	2006	The aggregation mechanism is, therefore, believed to be due to hydrogen-bonding between the hydrogens of the carboxylic acid groups and the ether oxygens present on the surface of the PEO-functionalized particles.	Hydrogen	63-71	twinkle mtDNA helicase	Homo sapiens	184-187
16732655-9	2006	The aggregation mechanism is, therefore, believed to be due to hydrogen-bonding between the hydrogens of the carboxylic acid groups and the ether oxygens present on the surface of the PEO-functionalized particles.	Hydrogen	92-101	twinkle mtDNA helicase	Homo sapiens	184-187
16737856-6	2006	A very good correlation was found between the extent of limited tryptic proteolysis and both the hydrogen bond distance between alphaX181 and betaSer178, obtained from the molecular dynamics simulation, and the hydrogen bond strength, evaluated by HINT, an empirical force field that takes into account both enthalpic and entropic contributions.	Hydrogen	211-219	histidine triad nucleotide binding protein 1	Homo sapiens	248-252
16731963-6	2006	This bend is stabilized by a network of hydrogen bonds involving the side chain of residue D23 and the amide hydrogens of adjacent residues G25, S26, N27, and K28, as well as by a salt bridge formed between side chains of K28 and E22.	Hydrogen	40-48	keratin 28	Homo sapiens	222-225
16731963-6	2006	This bend is stabilized by a network of hydrogen bonds involving the side chain of residue D23 and the amide hydrogens of adjacent residues G25, S26, N27, and K28, as well as by a salt bridge formed between side chains of K28 and E22.	Hydrogen	109-118	keratin 28	Homo sapiens	159-162
16731963-6	2006	This bend is stabilized by a network of hydrogen bonds involving the side chain of residue D23 and the amide hydrogens of adjacent residues G25, S26, N27, and K28, as well as by a salt bridge formed between side chains of K28 and E22.	Hydrogen	109-118	keratin 28	Homo sapiens	222-225
16686515-1	2006	The thermal chemistry of 1-methyl-1-cyclopentene (1MCp(=)) and methylene cyclopentane (MeCp) was investigated on clean and hydrogen- and deuterium-predosed Pt(111) single-crystal surfaces by temperature-programmed desorption and reflection-absorption infrared spectroscopy.	Hydrogen	123-131	C-C motif chemokine ligand 28	Homo sapiens	87-91
16513268-5	2006	We found that phosphorylation at Y1105, a major tyrosine phosphorylation site on p190 RhoGAP, is decreased 1h after the conditioning in the hippocampus of wild-type mice, but not of Ptprz-deficient mice.	Hydrogen	107-109	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	182-187
16686515-3	2006	The MeCp to 1MCp(=) isomerization is aided by the presence of coadsorbed hydrogen, and occurs through the formation of a common 1-methyl-1-cyclopentyl (1MCp-Pt) surface intermediate; that intermediate then undergoes beta-hydride elimination selectively at the ring position to form the 1MCp(=) product.	Hydrogen	73-81	C-C motif chemokine ligand 28	Homo sapiens	4-8
16669651-5	2006	The crystal structure of this inhibitor bound to CDK2/cyclin A was determined and shows an unusual network of hydrogen bonds.	Hydrogen	110-118	cyclin A2	Homo sapiens	54-62
16413230-9	2006	Repair proficient WI38-VA fibroblasts and transfected XP-A cells expressing 150,000 molecules of XPA/cell removed (6-4) photoproducts from the genome with a half-life of 1h.	Hydrogen	170-172	XPA, DNA damage recognition and repair factor	Homo sapiens	97-100
16669657-4	2006	The complex formation was further confirmed by observation of induced CD signal corresponding to the SQ chromophore at 610 nm, upfield shift (about Deltadelta 0.1 ppm) of aromatic protons of SQ in 1H NMR spectra, and decrease in current intensity (CV) of SQ when bound to BSA.	Hydrogen	197-199	albumin	Homo sapiens	272-275
16649792-5	2006	The C-H...F hydrogen bonding between the ortho carbon of the phenyl ring and the fluorine of the BF2 group plays an important role in the formation of the adlayers.	Hydrogen	12-20	forkhead box G1	Homo sapiens	97-100
16625251-0	2006	Contrasting photochemical and thermal reactivity of Ru(CO)2(PPh3)(dppe) towards hydrogen rationalised by parahydrogen NMR and DFT studies.	Hydrogen	80-88	caveolin 1	Homo sapiens	60-64
16625251-1	2006	The synthesis, characterisation and thermal and photochemical reactivity of Ru(CO)2(PPh3)(dppe) 1 towards hydrogen are described.	Hydrogen	106-114	caveolin 1	Homo sapiens	84-88
16513636-4	2006	A close look at the hydrogen-bonding possibilities around the distal His in cAOS suggested that the imidazole ring is rotated by 180 degrees relative to that of catalase because of the hydrogen bond between Thr-66 and the distal His-67.	Hydrogen	20-28	catalase	Homo sapiens	161-169
16513636-4	2006	A close look at the hydrogen-bonding possibilities around the distal His in cAOS suggested that the imidazole ring is rotated by 180 degrees relative to that of catalase because of the hydrogen bond between Thr-66 and the distal His-67.	Hydrogen	185-193	catalase	Homo sapiens	161-169
16734752-5	2006	This process, termed regulatory volume increase is often mediated by the ubiquitous sodium/hydrogen ion exchanger, NHE1.	Hydrogen	91-99	solute carrier family 9 member A1	Homo sapiens	115-119
16679607-2	2006	The pinched cone conformation of syn-2(2),4(2)-dihydroxy-1(2),3(2)-bis(prop-2-enyloxy)thiacalix[4]arene, C30H24O4S4, (3a), is stabilized by two intramolecular hydrogen bonds, remarkably formed from both OH groups to the same ether O atom.	Hydrogen	159-167	synapsin II	Homo sapiens	33-38
16413740-4	2006	The negative DeltaH degrees and positive DeltaS degrees values in case of GEM-BSA and GEM-HSA complexes showed that both hydrogen bonds and hydrophobic interactions play a role in the binding of GEM to BSA or HSA.	Hydrogen	121-129	albumin	Homo sapiens	78-81
16413740-4	2006	The negative DeltaH degrees and positive DeltaS degrees values in case of GEM-BSA and GEM-HSA complexes showed that both hydrogen bonds and hydrophobic interactions play a role in the binding of GEM to BSA or HSA.	Hydrogen	121-129	albumin	Homo sapiens	202-205
16411898-2	2006	For the subtilisin NK (nattokinase), a bacterial serine protease, construction and analysis of a three-dimensional structural model suggested that several hydrogen bonds formed by four residues function to stabilize the transition state of the hydrolysis reaction.	Hydrogen	155-163	coagulation factor II, thrombin	Homo sapiens	49-64
16672462-4	2006	The strain is able to reduce metals such as Fe(III), Co(III), Cr(VI), Mn(IV), and U(VI) as electron acceptors while using lactate, formate, pyruvate, or hydrogen as an electron donor.	Hydrogen	153-161	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	47-50
16672462-4	2006	The strain is able to reduce metals such as Fe(III), Co(III), Cr(VI), Mn(IV), and U(VI) as electron acceptors while using lactate, formate, pyruvate, or hydrogen as an electron donor.	Hydrogen	153-161	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	53-60
16719114-5	2006	However, the addition of constituents (SO4(2-), SO3(2-), HS-, CI-, HCO3-, OH-, and humic acid) on the order of representative concentrations for drinking water decreased the NO3- reduction rate.	Hydrogen	57-59	NBL1, DAN family BMP antagonist	Homo sapiens	174-177
16410051-5	2006	This association was even stronger in APOE e4 negatives FFTD (H2: OR = 2.9, P = 0.001; H2H2: OR = 12.67, P = 0.001).	Hydrogen	62-64	apolipoprotein E	Homo sapiens	38-42
16640558-3	2006	Crystallographic data of the HNF-4alpha ligand-binding domain (LBD) demonstrated that the homodimer interface is composed of residues in helices 7, 9 and 10 with intermolecular salt bridges, hydrogen bonds and hydrophobic interactions contributing to the stability of the interface.	Hydrogen	191-199	hepatocyte nuclear factor 4 alpha	Homo sapiens	29-39
16640558-3	2006	Crystallographic data of the HNF-4alpha ligand-binding domain (LBD) demonstrated that the homodimer interface is composed of residues in helices 7, 9 and 10 with intermolecular salt bridges, hydrogen bonds and hydrophobic interactions contributing to the stability of the interface.	Hydrogen	191-199	superoxide dismutase 1	Homo sapiens	90-99
16634575-3	2006	This is exemplified by Co(II) dimers with Co(II)-mu-Cl-Co(II) motifs, in which the chloro ligand is involved in four intramolecular hydrogen bonds.	Hydrogen	132-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
16634575-3	2006	This is exemplified by Co(II) dimers with Co(II)-mu-Cl-Co(II) motifs, in which the chloro ligand is involved in four intramolecular hydrogen bonds.	Hydrogen	132-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16634575-3	2006	This is exemplified by Co(II) dimers with Co(II)-mu-Cl-Co(II) motifs, in which the chloro ligand is involved in four intramolecular hydrogen bonds.	Hydrogen	132-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16697681-8	2006	As early as 1h postinfection, three genes, (IEX-1, IRF-1, DEC-1) all implicated in apoptosis pathways, were upregulated.	Hydrogen	12-14	immediate early response 3	Homo sapiens	44-49
16697681-8	2006	As early as 1h postinfection, three genes, (IEX-1, IRF-1, DEC-1) all implicated in apoptosis pathways, were upregulated.	Hydrogen	12-14	interferon regulatory factor 1	Homo sapiens	51-56
16281046-2	2006	In co-crystals with PDE5, one of the rings of vardenafil or sildenafil interacts with Tyr(612), a catalytic site AA, via (1) a hydrogen bond with a water molecule and (2) hydrophobic bonds.	Hydrogen	127-135	phosphodiesterase 5A	Homo sapiens	20-24
16281046-3	2006	For mutant PDE5(Y612F), which ablates hydrogen-bonding potential, vardenafil or sildenafil inhibition was strengthened (2.2- or 3.0-fold, respectively), implying that the Tyr(612) hydroxyl is a negative determinant for these inhibitors.	Hydrogen	38-46	phosphodiesterase 5A	Homo sapiens	11-15
16281046-4	2006	For mutant PDE5(Y612A), which ablates both hydrogen bonding and hydrophobic-bonding potential, vardenafil inhibition was weakened much more than sildenafil inhibition (122- and 26-fold, respectively), suggesting that hydrophobic bonds involving Tyr(612) are stronger for vardenafil than for sildenafil.	Hydrogen	43-51	phosphodiesterase 5A	Homo sapiens	11-15
16287119-0	2006	Functional role of a protein foldon--an Omega-loop foldon controls the alkaline transition in ferricytochrome c. Hydrogen exchange results for cytochrome c and several other proteins show that they are composed of a number of foldon units which continually unfold and refold and account for some functional properties.	Hydrogen	113-121	cytochrome c, somatic	Homo sapiens	99-111
16755932-6	2006	This scFv was detected in brain tissues 1h later by capillary depletion method, which indicates that scFv protein can permeate through the blood brain barrier by mediation of the TfR receptor.	Hydrogen	40-42	immunglobulin heavy chain variable region	Homo sapiens	5-9
16755932-6	2006	This scFv was detected in brain tissues 1h later by capillary depletion method, which indicates that scFv protein can permeate through the blood brain barrier by mediation of the TfR receptor.	Hydrogen	40-42	immunglobulin heavy chain variable region	Homo sapiens	101-105
16620090-7	2006	Our simulation results strongly support the design of bioactive insulin analogues that involves altering hydrogen bonding and hydrophobic interactions across the beta-sheet dimer interface.	Hydrogen	105-113	insulin	Homo sapiens	64-71
16600877-3	2006	Unlike the chromodomain that recognizes the methylated H3-K4 through a hydrophobic cage, the specificity of WDR5 for methylated H3-K4 is conferred by the nonconventional hydrogen bonds between the two zeta-methyl groups of the dimethylated Lys4 and the carboxylate oxygen of Glu322 in WDR5.	Hydrogen	170-178	WD repeat domain 5	Homo sapiens	108-112
16599438-5	2006	The calculations resulted in three stationary points from which two (I-1, I-2) corresponded to structures involving the O-H...F hydrogen bond and the third one (I-3) to the non-hydrogen-bonded structure.	Hydrogen	128-136	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	69-72
16599438-6	2006	The topological analysis of the distribution of the charge density (AIM theory) confirmed the existence of the hydrogen bond in I-1, I-2 complexes and indicated weak interaction between the oxygen atom of CH(3)OH and three fluorine atoms of CF(4) in the I-3 complex.	Hydrogen	111-119	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	128-131
16584196-12	2006	Both the Lys 79 --&gt; Ala and Asn 52 --&gt; Gly mutations are expected to affect the buried hydrogen bond network of cytochrome c, suggesting that this network is an important modulator of the acid unfolding of cytochrome c.	Hydrogen	93-101	cytochrome c, somatic	Homo sapiens	118-130
16584196-12	2006	Both the Lys 79 --&gt; Ala and Asn 52 --&gt; Gly mutations are expected to affect the buried hydrogen bond network of cytochrome c, suggesting that this network is an important modulator of the acid unfolding of cytochrome c.	Hydrogen	93-101	cytochrome c, somatic	Homo sapiens	212-224
16600877-4	2006	The three amino acids Ala-Arg-Thr preceding Lys4 form most of the specific contacts with WDR5, with Ala1 forming intermolecular hydrogen bonds and salt bridges, and the side chain of Arg2 inserting into the central channel of WDR5.	Hydrogen	128-136	WD repeat domain 5	Homo sapiens	89-93
16562965-0	2006	Proton-transfer and H2-elimination reactions of main-group hydrides EH4- (E = B, Al, Ga) with alcohols.	Hydrogen	20-22	epoxide hydrolase 4	Homo sapiens	68-71
16562965-4	2006	The transition state (TS) is the dihydrogen complex stabilized by a hydrogen bond with the anion [EH3(eta2-H2)...OR-].	Hydrogen	35-43	epoxide hydrolase 3	Homo sapiens	98-101
16789425-0	2006	Quantitative structure-activity relationships (QSars) in CYP3A4 inhibitors: the importance of lipophilic character and hydrogen bonding.	Hydrogen	119-127	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	57-63
16505904-1	2006	2,4,6-trialkylbenzenethiols react with [RuCl2(PPh3)3] to give Ru products with the alkyl substituents forming M-C sigma bonds, carbene, carbene with a S alpha-heteroatom, agostic hydrogen interaction or a simple tetrahedral Ru(II) species, depending on the substituent.	Hydrogen	179-187	caveolin 1	Homo sapiens	46-50
16488667-5	2006	Urocortin decreased the serum ACE level 1h after administration, whereas tissue ACE immunoreactivity and mRNA did not change.	Hydrogen	40-42	angiotensin I converting enzyme	Rattus norvegicus	30-33
16892371-1	2006	Recently developed hydrogen-bonding and hydrophobic analysis algorithms were used to investigate the interaction properties of the ATP binding sites of CDK2, CDK4, and ERK2.	Hydrogen	19-27	mitogen-activated protein kinase 1	Homo sapiens	168-172
16509574-3	2006	An X-ray crystal structure of this series bound in the ATP binding pocket of unphosphorylated p38alpha established the presence of a unique hydrogen bond between the exocyclic amine of the inhibitor and threonine 106 which likely contributes to the selectivity for p38.	Hydrogen	140-148	mitogen-activated protein kinase 14	Homo sapiens	94-102
16509574-3	2006	An X-ray crystal structure of this series bound in the ATP binding pocket of unphosphorylated p38alpha established the presence of a unique hydrogen bond between the exocyclic amine of the inhibitor and threonine 106 which likely contributes to the selectivity for p38.	Hydrogen	140-148	mitogen-activated protein kinase 14	Homo sapiens	94-97
16503655-0	2006	Folding kinetics of the S100A11 protein dimer studied by time-resolved electrospray mass spectrometry and pulsed hydrogen-deuterium exchange.	Hydrogen	113-121	S100 calcium binding protein A11	Homo sapiens	24-31
16509611-1	2006	The QCISD and QCISD(T) quantum chemical methods have been used to characterize the energetics of various possible mechanisms for the formation of HCF2+ from the bond-forming reaction of CF3(2+) with H2.	Hydrogen	199-201	host cell factor C2	Homo sapiens	146-150
16507366-2	2006	To elucidate the molecular mechanism of the Keap1 and Nrf2 interaction, we resolved the six-bladed beta propeller crystal structure of the Kelch/DGR and CTR domains of mouse Keap1 and revealed that extensive inter- and intrablade hydrogen bonds maintain the structural integrity and proper association of Keap1 with Nrf2.	Hydrogen	230-238	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
16442702-9	2006	In a second area of interest, we are investigating the role of hydrophobic and hydrogen-bonding interactions at the start of helix 12 in the activity of the hERalpha.	Hydrogen	79-87	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	157-165
16493051-4	2006	Testing of three models for Stat3 Src homology 2-pY ligand binding in vitro and in vivo revealed unique determinants for Stat3 recruitment and activation by the G-CSFR, the side chain of Stat3 R609, which interacts with the pY ligand phosphate group, and the peptide amide hydrogen of E638, which bonds with oxygen/sulfur within the + 3 Q/C side chain of the pY ligand when it assumes a beta turn.	Hydrogen	273-281	signal transducer and activator of transcription 3	Homo sapiens	28-33
16493051-4	2006	Testing of three models for Stat3 Src homology 2-pY ligand binding in vitro and in vivo revealed unique determinants for Stat3 recruitment and activation by the G-CSFR, the side chain of Stat3 R609, which interacts with the pY ligand phosphate group, and the peptide amide hydrogen of E638, which bonds with oxygen/sulfur within the + 3 Q/C side chain of the pY ligand when it assumes a beta turn.	Hydrogen	273-281	signal transducer and activator of transcription 3	Homo sapiens	121-126
16493051-4	2006	Testing of three models for Stat3 Src homology 2-pY ligand binding in vitro and in vivo revealed unique determinants for Stat3 recruitment and activation by the G-CSFR, the side chain of Stat3 R609, which interacts with the pY ligand phosphate group, and the peptide amide hydrogen of E638, which bonds with oxygen/sulfur within the + 3 Q/C side chain of the pY ligand when it assumes a beta turn.	Hydrogen	273-281	signal transducer and activator of transcription 3	Homo sapiens	121-126
16520549-4	2006	A C-peptide can be divided into three domains, the N-terminal hydrophobic domain (HPD), middle interface domain (IFD), and C-terminal hydrogen domain (HGD), based on the binding property with an N-peptide.	Hydrogen	134-142	insulin	Homo sapiens	2-11
16477002-9	2006	The IL-2/gamma(c) interface itself exhibits the smallest buried surface and the fewest hydrogen bonds in the complex, which is consistent with its promiscuous use in other cytokine receptor complexes.	Hydrogen	87-95	interleukin 2	Homo sapiens	4-8
16376376-10	2006	Unlike their precursors, the pressure-insensitivity of mature insulin fibrils demonstrates that an extensive hydrogen bonding network and optimized side-chain packing are crucial for their stability.	Hydrogen	109-117	insulin	Homo sapiens	62-69
16482296-7	2006	It was found that the change of the hydrogen bonding network occurred by the two state manner in entire refolding process of cytochrome c.	Hydrogen	36-44	cytochrome c, somatic	Homo sapiens	125-137
16461914-4	2006	The NMR spectrum (15N,1H transverse relaxation optimized spectroscopy) of full-length p53 was close to that expected from the sum of the spectra of isolated individual domains.	Hydrogen	22-24	tumor protein p53	Homo sapiens	86-89
16471857-9	2006	In the second subpathway, H(2) is added across the Au-OH bond to form water and another Au-H bond (DeltaE(act) = 22.6 kcal/mol).	Hydrogen	26-30	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	88-92
16331717-4	2006	The 1H NMR analysis of the TCNB complexes 3@1 b and 3@2 a at low temperatures (T&lt;-80 degrees C) showed that 3 undergoes fast rotation inside the cavity of tweezer 1 b or clip 2 a (rotational barrier: DeltaG( not equal)=11.7 and 8.3 kcal mol(-1), respectively).	Hydrogen	4-6	CAP-Gly domain containing linker protein 2	Homo sapiens	173-179
16266835-0	2006	Solution 1H NMR investigation of Zn2+ and Cd2+ binding to amyloid-beta peptide (Abeta) of Alzheimer"s disease.	Hydrogen	9-11	amyloid beta precursor protein	Homo sapiens	80-85
16266835-3	2006	We have used 1H NMR and CD to probe the binding of Zn2+ to Abeta(1-28).	Hydrogen	13-15	amyloid beta precursor protein	Homo sapiens	59-64
16266835-4	2006	Zinc binding to Abeta causes a number of 1H NMR resonances to exhibit intermediate exchange broadening upon Zn2+ addition, signals in slow and fast exchange are also observed.	Hydrogen	41-43	amyloid beta precursor protein	Homo sapiens	16-21
16272441-9	2006	The tbeta(4)-induced conformational change presumably accounts for the reduced rate of amide hydrogen exchange from actin monomers and may contribute to nucleotide-dependent, high affinity binding.	Hydrogen	93-101	thymosin beta 4 X-linked	Homo sapiens	4-12
16299777-4	2006	However, the functional specificities of these domains could be due to the dynamics of the individual amino acid residues, as has been shown earlier in the case of backbone dynamics of 15N-1H of dsRNA binding motifs (dsRBMs) of human protein kinase R (PKR) (Nanduri S, Rahman F, Williams BRG, Qin J. EMBO J 2000;19:5567-5574).	Hydrogen	189-191	forkhead box G1	Homo sapiens	293-296
16826916-5	2006	Quantum chemistry calculation showed that this enhancement of RLS occurred because the neutral molecules of quercetin assembled into super-molecular aggregates by 4-4" hydrogen-bond.	Hydrogen	168-176	RLS1	Homo sapiens	62-65
16288975-4	2006	The selective iNOS inhibitor 1,3-PBIT (10 mg/kg, ip; 1h after endotoxin) prevented endotoxin-induced decrease in MAP, renal CYP 4A1/A3 protein level and CYP 4A activity and increase in systemic and renal nitrite production.	Hydrogen	53-55	nitric oxide synthase 2	Rattus norvegicus	14-18
16288975-4	2006	The selective iNOS inhibitor 1,3-PBIT (10 mg/kg, ip; 1h after endotoxin) prevented endotoxin-induced decrease in MAP, renal CYP 4A1/A3 protein level and CYP 4A activity and increase in systemic and renal nitrite production.	Hydrogen	53-55	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	124-131
16275081-2	2006	A strategy of pseudo six-membered ring formed through intramolecular hydrogen bonding in salicylanilides is employed to mimic the planar pyrimidine ring of quinazoline EGFR inhibitors.	Hydrogen	69-77	epidermal growth factor receptor	Homo sapiens	168-172
15978864-4	2006	HLBr gives harder complexation reaction with Zn(II) according to HLNO2 because of the stronger intramolecular hydrogen bonding in HLBr, and the both ligands react easier with Zn(NO3)2 than ZnCl2 and ZnI2.	Hydrogen	110-118	NBL1, DAN family BMP antagonist	Homo sapiens	178-181
16430211-0	2006	The crucial importance of chemistry in the structure-function link: manipulating hydrogen bonding in iron-containing superoxide dismutase.	Hydrogen	81-89	superoxide dismutase 1	Homo sapiens	117-137
16401081-10	2006	These results suggest that removal of Tyr348-Tyr385 hydrogen bonding in PGHS-2 allows greater conformational flexibility in the cyclooxygenase active site, resulting in altered interactions with inhibitors and altered Tyr385 radical behavior.	Hydrogen	52-60	prostaglandin-endoperoxide synthase 2	Homo sapiens	72-78
16337024-12	2006	We conclude that NO3- suppressed the production of H2(g) by competing with water for Fe0 oxidation, especially at the beginning of water treatment when Fe0 is highly reactive.	Hydrogen	51-53	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
17168729-4	2006	Two evidences playing important roles for the inhibition by the active compounds, are 1) C-1 and C-3" hydroxyl groups formed hydrogen bonds with COX-2/COX-1 Val523/Ile523 and Arg120, respectively, 2) hydrogen at C-5 of the naphthalene nucleus was attracted rather close to the phenolic group of Tyr385 due to van der Waals interaction.	Hydrogen	125-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
16392803-6	2006	This led to the proposal of an interaction model inside the 5-LOX active site, consisting of four major and two secondary interaction points: on one hand, two hydrophobic groups, an aromatic ring, and a hydrogen bond acceptor, and, on the other hand, an acidic moiety and an additional hydrogen bond acceptor.	Hydrogen	203-211	arachidonate 5-lipoxygenase	Homo sapiens	60-65
16392803-6	2006	This led to the proposal of an interaction model inside the 5-LOX active site, consisting of four major and two secondary interaction points: on one hand, two hydrophobic groups, an aromatic ring, and a hydrogen bond acceptor, and, on the other hand, an acidic moiety and an additional hydrogen bond acceptor.	Hydrogen	286-294	arachidonate 5-lipoxygenase	Homo sapiens	60-65
16392812-4	2006	We have also revealed that, similar to 4"-oxoadenosine analogues, at least one hydrogen on the 5"-uronamide moiety was necessary for high-affinity binding at the human A(3) AR, presumably to allow this group to donate a H bond within the binding site.	Hydrogen	79-87	adenosine A3 receptor	Homo sapiens	168-175
16454511-0	2006	Influence of C18 long chain fatty acids on hydrogen metabolism.	Hydrogen	43-51	Bardet-Biedl syndrome 9	Homo sapiens	13-16
16454746-10	2006	Thus, hydrogen bond formation is considered to be involved in substrate recognition and/or transport processes of ABCG2.	Hydrogen	6-14	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	114-119
17168729-4	2006	Two evidences playing important roles for the inhibition by the active compounds, are 1) C-1 and C-3" hydroxyl groups formed hydrogen bonds with COX-2/COX-1 Val523/Ile523 and Arg120, respectively, 2) hydrogen at C-5 of the naphthalene nucleus was attracted rather close to the phenolic group of Tyr385 due to van der Waals interaction.	Hydrogen	200-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
16609835-0	2006	1H and 15N resonance assignment of the first module of FGFR1.	Hydrogen	0-2	fibroblast growth factor receptor 1	Homo sapiens	55-60
16456705-0	2006	1H, 13C and 15N resonance assignments of the C-terminal domain of RP2.	Hydrogen	0-2	RP2 activator of ARL3 GTPase	Homo sapiens	66-69
18038616-2	2006	The rise of hydrogen sulfur levels was shown also in brains of BALB/c females and B10.PL males, however in BALB/c male brains there is no statistically significant difference.	Hydrogen	12-20	granzyme C	Mus musculus	82-85
16609836-0	2006	1H, 15N, and 13C resonance assignment of the C2A domain of rabphilin 3A.	Hydrogen	0-2	rabphilin 3A	Homo sapiens	59-71
16865415-0	2006	1H, 13C and 15N backbone resonance assignments of the DUF589 domain from human HSPC144 protein.	Hydrogen	0-2	thymocyte nuclear protein 1	Homo sapiens	79-86
16636753-0	2006	13C, 15N and 1H resonance assignment of the PDZ1 domain of MAGI-1 using QUASI.	Hydrogen	13-15	membrane associated guanylate kinase, WW and PDZ domain containing 1	Homo sapiens	59-65
17098586-6	2006	Interestingly, the combined effect of SMF (128mT, 1h/day during 30 consecutive days) and Cd (40mg/L, per os) decreased the GPx and CAT activities in liver compared to cadmium treated group.	Hydrogen	50-52	catalase	Rattus norvegicus	131-134
17031525-0	2006	1H, 13C and 15N resonance assignments of the VAP-A: OSBP complex.	Hydrogen	0-2	VAMP associated protein A	Homo sapiens	45-50
17031525-0	2006	1H, 13C and 15N resonance assignments of the VAP-A: OSBP complex.	Hydrogen	0-2	oxysterol binding protein	Homo sapiens	52-56
16426065-8	2006	The FLAME alignment automatically identified three common pharmacophores: a base, a hydrogen-bond acceptor, and a hydrophobe/aromatic ring.	Hydrogen	84-92	CASP8 and FADD like apoptosis regulator	Homo sapiens	4-9
16191480-3	2006	Asp-351 and Leu-536 participate in hydrogen bond (Asp-351) and hydrophobic (Leu-536) interactions at the start of helix 12 in the ligand-binding domain (LBD) of the ERalpha.	Hydrogen	35-43	estrogen receptor 1	Homo sapiens	165-172
16292670-0	2006	Stability and fluctuations of amide hydrogen bonds in a bacterial cytochrome c: a molecular dynamics study.	Hydrogen	36-44	cytochrome c, somatic	Homo sapiens	66-78
16292670-1	2006	Molecular dynamics (MD) simulations on a bacterial cytochrome c were performed to investigate the lifetime and fluctuations of backbone hydrogen bonds and to correlate these data with protection factors for hydrogen exchange measured by NMR spectroscopy (Bartalesi et al.	Hydrogen	207-215	cytochrome c, somatic	Homo sapiens	51-63
17062624-5	2006	Remarkably, this inhibitor mimics the crucial hydrogen bonding and electrostatic interactions previously observed in UNG2 complexes with damaged uracilated DNA.	Hydrogen	46-54	uracil DNA glycosylase	Homo sapiens	117-121
16618987-5	2006	However, at a low concentration of H2O2 and in the presence of a suitable hydrogen donor, e.g. ethanol, methanol, phenol, and others, catalase acts peroxidically, removing H2O2, but oxidizing its substrate (peroxidatic reaction).	Hydrogen	74-82	catalase	Homo sapiens	134-142
15970461-2	2006	In protic methanol, 1 crystallizes in monoclinic space group P2(1)/c (1a) comprising of 2D hydrogen bonded network via cyclic dimers.	Hydrogen	91-99	cyclin dependent kinase inhibitor 1A	Homo sapiens	61-68
18221192-2	2006	TRPV1 is a voltage-dependent cation channel, which can be activated at physiological membrane potentials by stimuli including noxious heat (&gt;42 degrees), capsaicin, hydrogen ions and anandamide.	Hydrogen	168-176	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
16344246-5	2006	The intermolecular hydrogen bondings and molecular alignments patterns result from both the experimental data and the computational models are performed for D3, D6, and D10, respectively, in the present study.	Hydrogen	19-27	CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion	Homo sapiens	169-172
16284183-11	2005	Perfusion of H2(O2) was sufficient to induce Akt activation.	Hydrogen	13-15	AKT serine/threonine kinase 1	Rattus norvegicus	45-48
16363796-10	2005	A comparison of the NIPs and tonoplast-intrinsic proteins (TIP) shows that the H2 residue can predict the transport profile for water and glycerol with histidine found in TIP-like aquaporins, tryptophan found in aquaglyceroporins (NIP I), and alanine found in water-impermeable glyceroporins (AtNIP6;1).	Hydrogen	79-81	NOD26-like intrinsic protein 6;1	Arabidopsis thaliana	293-301
16854005-1	2005	Molecular dynamics (MD) simulations and hydrogen bonding energy (HBE) calculations have been performed on the prereactive enzyme-substrate complexes (ES), transition states (TS1), and intermediates (INT1) for acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylcholine (ACh), butyrylcholinesterase (BChE)-catalyzed hydrolysis of ACh, and BChE-catalyzed hydrolysis of (+)/(-)-cocaine to examine the protein environmental effects on the catalytic reactions.	Hydrogen	40-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	209-229
16333500-1	2005	Treatment of a glycosylamine derived Cu(II) complex with ethylamine resulted in crystal-to-crystal transformation from trinuclear complex [Cu3(L1)2(EtNH2)2(MeOH)2]x2MeOHxCHCl3 (2x2MeOHxCHCl3) to a dimeric structure of mononuclear complex [Cu(HL1)(EtNH2)] (3) through proton transfer reaction and rearrangement of hydrogen bonding networks.	Hydrogen	313-321	L1 cell adhesion molecule	Homo sapiens	139-145
16854005-3	2005	Whereas G121/G116, G122/G117, and A204/A199 of AChE/BChE all can form hydrogen bonds with ACh to stabilize the transition state during the ACh hydrolysis, BChE only uses G117 and A199 to form hydrogen bonds with cocaine.	Hydrogen	70-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-51
16854005-3	2005	Whereas G121/G116, G122/G117, and A204/A199 of AChE/BChE all can form hydrogen bonds with ACh to stabilize the transition state during the ACh hydrolysis, BChE only uses G117 and A199 to form hydrogen bonds with cocaine.	Hydrogen	192-200	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-51
16242774-6	2005	In addition, internalization of GalR1 after 1h of agonist stimulation with the GalR1 agonist galanin (1-29) was observed with time lapse fluorescence imaging, whereas stimulation with the GalR2 specific agonist galanin (2-11) did not lead to internalization.	Hydrogen	44-46	Galanin receptor type 1	Cricetulus griseus	32-37
15878248-0	2005	Serial MR imaging and 1H-MR spectroscopy of unidentified bright objects in a case of neurofibromatosis type 1.	Hydrogen	22-24	neurofibromin 1	Homo sapiens	85-109
15878248-1	2005	Serial study using MR imaging and 1H-MR spectroscopy (1H-MRS) of unidentified bright objects (UBO) in a 9-year-old boy with neurofibromatosis type 1 (NF1) is described.	Hydrogen	34-36	neurofibromin 1	Homo sapiens	150-153
15878248-1	2005	Serial study using MR imaging and 1H-MR spectroscopy (1H-MRS) of unidentified bright objects (UBO) in a 9-year-old boy with neurofibromatosis type 1 (NF1) is described.	Hydrogen	54-56	neurofibromin 1	Homo sapiens	124-148
15878248-1	2005	Serial study using MR imaging and 1H-MR spectroscopy (1H-MRS) of unidentified bright objects (UBO) in a 9-year-old boy with neurofibromatosis type 1 (NF1) is described.	Hydrogen	54-56	neurofibromin 1	Homo sapiens	150-153
15878248-7	2005	The longitudinal follow-up using MR image and 1H-MRS was useful for metabolic evaluation of UBO in patients with NF1.	Hydrogen	46-48	neurofibromin 1	Homo sapiens	113-116
16326832-8	2005	These data suggest a role of Asp-351 in inducing and stabilizing the active conformation of ERalpha, and our results experimentally confirm the concept that Asp-351 in helix 3 interacts with the amide hydrogen of L540 in helix 12 to form a transcriptionally competent surface for binding p160 coactivators.	Hydrogen	201-209	estrogen receptor 1	Homo sapiens	92-99
16326832-8	2005	These data suggest a role of Asp-351 in inducing and stabilizing the active conformation of ERalpha, and our results experimentally confirm the concept that Asp-351 in helix 3 interacts with the amide hydrogen of L540 in helix 12 to form a transcriptionally competent surface for binding p160 coactivators.	Hydrogen	201-209	MYB binding protein 1a	Homo sapiens	288-292
16319884-4	2005	In the centre of the water pathway, the closed pore in junctional AQP0 retains only three water molecules, which are too widely spaced to form hydrogen bonds with each other.	Hydrogen	143-151	major intrinsic protein of lens fiber	Homo sapiens	66-70
16302800-2	2005	The three-dimensional structure of PIM-1 is characterized by an unique hinge region which lacks a second hydrogen bond donor and makes it particularly important to determine how inhibitors bind to this kinase.	Hydrogen	105-113	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	35-40
16373716-6	2005	Loss of these contacts results in a destabilizing effect on two key hydrogen bonds between imatinib and Asp310 and Thr670 of cKIT.	Hydrogen	68-76	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	125-129
16242774-6	2005	In addition, internalization of GalR1 after 1h of agonist stimulation with the GalR1 agonist galanin (1-29) was observed with time lapse fluorescence imaging, whereas stimulation with the GalR2 specific agonist galanin (2-11) did not lead to internalization.	Hydrogen	44-46	Galanin receptor type 1	Cricetulus griseus	79-84
16242774-6	2005	In addition, internalization of GalR1 after 1h of agonist stimulation with the GalR1 agonist galanin (1-29) was observed with time lapse fluorescence imaging, whereas stimulation with the GalR2 specific agonist galanin (2-11) did not lead to internalization.	Hydrogen	44-46	galanin peptides	Cricetulus griseus	93-100
16246417-12	2005	Subcutaneous injection of 1000 ng AVP 1h before 0.4 mg i.c.v.	Hydrogen	38-40	arginine vasopressin	Rattus norvegicus	34-37
16216268-6	2005	A comparison of native solvent exchange in wild-type and mutated IL-1beta shows transmission of local destabilization along the hydrogen bond network of the beta-sheet.	Hydrogen	128-136	interleukin 1 beta	Homo sapiens	65-73
16285719-0	2005	Strongly hydrogen-bonded water molecule present near the retinal chromophore of Leptosphaeria rhodopsin, the bacteriorhodopsin-like proton pump from a eukaryote.	Hydrogen	9-17	rhodopsin	Homo sapiens	94-103
16157595-0	2005	On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant.	Hydrogen	47-55	seed linoleate 13S-lipoxygenase-1	Glycine max	144-158
16296861-4	2005	The cooperation among the photochemical structural changes of six azobenzene moieties in [Co(II)(dmAB)3](BF4)2 was investigated with 1H NMR spectroscopy.	Hydrogen	133-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-96
16296861-5	2005	The time-course change in the 1H NMR signals of the methyl protons indicated that each azobenzene moiety in [Co(II)(dmAB)3](BF4)2 isomerized to a cis isomer with a random probability of 50% and without interactions among the azobenzene moieties.	Hydrogen	30-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-115
16129672-7	2005	We have shown that changes induced to the positions of Trp-741, Thr-877, and Met-895 allow for ligand accommodation within the AR binding pocket and that a water-mediated hydrogen bond to the backbone oxygen of Leu-873 and the ketone of hydroxyflutamide is present when bound to the T877A AR variant.	Hydrogen	171-179	androgen receptor	Homo sapiens	127-129
16129672-7	2005	We have shown that changes induced to the positions of Trp-741, Thr-877, and Met-895 allow for ligand accommodation within the AR binding pocket and that a water-mediated hydrogen bond to the backbone oxygen of Leu-873 and the ketone of hydroxyflutamide is present when bound to the T877A AR variant.	Hydrogen	171-179	androgen receptor	Homo sapiens	289-291
16229033-0	2005	A neutron diffraction study of [OsClH3(PPh3)3]: a complex containing a highly "stretched" dihydrogen ligand.	Hydrogen	90-100	caveolin 1	Homo sapiens	39-43
16248652-0	2005	Triplet state photosensitization of nanocrystalline metal oxide electrodes by zinc-substituted cytochrome c: application to hydrogen evolution.	Hydrogen	124-132	cytochrome c, somatic	Homo sapiens	95-107
16838914-2	2005	The nonbonded site-site potential between two proximal hydrogen atoms on different methyl groups, V(nb)(d(HH)), is not Lennard-Jones- or Morse-like but is found to be pseudolinear in hydrogen-hydrogen internuclear separation, d(HH), for both neopentane and TMS.	Hydrogen	55-63	PYD and CARD domain containing	Homo sapiens	257-260
16838914-2	2005	The nonbonded site-site potential between two proximal hydrogen atoms on different methyl groups, V(nb)(d(HH)), is not Lennard-Jones- or Morse-like but is found to be pseudolinear in hydrogen-hydrogen internuclear separation, d(HH), for both neopentane and TMS.	Hydrogen	183-191	PYD and CARD domain containing	Homo sapiens	257-260
16838914-2	2005	The nonbonded site-site potential between two proximal hydrogen atoms on different methyl groups, V(nb)(d(HH)), is not Lennard-Jones- or Morse-like but is found to be pseudolinear in hydrogen-hydrogen internuclear separation, d(HH), for both neopentane and TMS.	Hydrogen	183-191	PYD and CARD domain containing	Homo sapiens	257-260
16121406-5	2005	On the other hand, the N1H tautomer 1a co-crystallizes with protonated ICH to give [1a x ICH2]NO3 (3), again with three hydrogen bonds between the partners, yet the acidic proton is disordered over the two entities.	Hydrogen	120-128	caspase 4	Homo sapiens	89-93
16223464-4	2005	The content of liquid fat was determined by low-field 1H NMR, which showed that milk from cows given the saturated fat diet also contained less liquid fat at both 4 degrees and 31 degrees C than the other type of milk.	Hydrogen	54-56	Weaning weight-maternal milk	Bos taurus	80-84
16316512-0	2005	Hydrogen-deuterium exchange in bovine serum albumin protein monitored by fourier transform infrared spectroscopy, part I: structural studies.	Hydrogen	0-8	albumin	Homo sapiens	38-51
16316513-0	2005	Hydrogen-deuterium exchange in bovine serum albumin protein monitored by Fourier transform infrared spectroscopy, part II: kinetic studies.	Hydrogen	0-8	albumin	Homo sapiens	38-51
16230521-11	2005	These indicate that membrane-bound ATP synthase functions as a receptor for CF6 and may have a previously unsuspected role in the genesis of hypertension by modulating the concentration of intracellular hydrogen.	Hydrogen	203-211	ATP synthase peripheral stalk subunit F6	Homo sapiens	76-79
16099662-3	2005	The formation of hydrogen bonds among the hydroxyl groups of the resveratrol phenyl rings, the backbone of Fe-heme and the carbonyl group of Leu294 inside the PGHS-1 peroxidase site, associated with the absence of His214 in the backbone of PGHS-1, are essential features that are required to maintain the aromatic rings of the natural product parallel to the Fe-heme group and transverse to the peroxidase access channel promoting a large steric hindrance at this site and its consequent selective inhibition.	Hydrogen	17-25	prostaglandin-endoperoxide synthase 1	Homo sapiens	159-165
16099662-3	2005	The formation of hydrogen bonds among the hydroxyl groups of the resveratrol phenyl rings, the backbone of Fe-heme and the carbonyl group of Leu294 inside the PGHS-1 peroxidase site, associated with the absence of His214 in the backbone of PGHS-1, are essential features that are required to maintain the aromatic rings of the natural product parallel to the Fe-heme group and transverse to the peroxidase access channel promoting a large steric hindrance at this site and its consequent selective inhibition.	Hydrogen	17-25	prostaglandin-endoperoxide synthase 1	Homo sapiens	240-246
16331426-0	2005	1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complex.	Hydrogen	0-2	LIM homeobox 3	Homo sapiens	49-53
16185715-0	2005	Hydrogen exchange solvent protection by an ATP analogue reveals conformational changes in ERK2 upon activation.	Hydrogen	0-8	mitogen-activated protein kinase 1	Homo sapiens	90-94
16218995-4	2005	The crystal structure reveals an interesting packing motif in which helical columns are stabilized by side chain-backbone hydrogen bonding involving the indole Nepsilon1H of Trp(2) as donor, and an acceptor C=O group from Leu(6) of a neighboring molecule.	Hydrogen	122-130	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	174-180
16185715-4	2005	In both active and inactive forms of ERK2, protection from hydrogen exchange by AMP-PNP binding was observed within conserved ATP binding motifs in the N-terminal lobe, which are known to directly interact with nucleotide in various protein kinases.	Hydrogen	59-67	mitogen-activated protein kinase 1	Homo sapiens	37-41
16185715-3	2005	Mass spectrometry was used to probe changes in hydrogen/deuterium exchange in the MAP kinase, ERK2, in the presence and absence of the ATP analogue, AMP-PNP.	Hydrogen	47-55	mitogen-activated protein kinase 1	Homo sapiens	94-98
16833273-1	2005	Diene-dienophile competing Diels-Alder reaction pathways of cyclopentadiene, 1H-, 2H- and 3H-phospholes with butadiene were explored at the B3LYP level using 6-31G(d) and 6-311+G(d,p) basis sets, and at the CCSD(T)/6-31G(d)//B3LYP/6-31G(d) level.	Hydrogen	77-79	SH2 domain containing 1A	Homo sapiens	142-145
16220982-8	2005	Of the amino acids tested, leucine provided the highest affinity at pY+1 and its main chain NH is involved with a hydrogen bond with Stat3, presumably Ser636.	Hydrogen	114-122	signal transducer and activator of transcription 3	Homo sapiens	133-138
16833277-0	2005	SN2-like reaction in hydrogen-bonded complexes: a theoretical study.	Hydrogen	21-29	solute carrier family 38 member 5	Homo sapiens	0-3
16383823-2	2005	We pay special attention to the recent precise determination of the strong shift and width of the kaonic hydrogen 1s state by the DEAR Collaboration that has challenged our theoretical understanding of this sector of strong interactions.	Hydrogen	105-116	FBXW7 antisense RNA 1	Homo sapiens	130-134
16172999-0	2005	Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL.	Hydrogen	103-111	BCL2 like 1	Homo sapiens	143-149
16190729-6	2005	In addition to the direct coordination of metyrapone to the heme iron, the hydrogen bond interaction between the inhibitor carbonyl group and the side chain of Ser119 also contributes significantly to stabilizing the CYP3A4-metyrapone complex.	Hydrogen	75-83	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	217-223
16175305-1	2005	In the presence of moderately strong acids in CH3CN, cobalt complexes with BF2-bridged diglyoxime ligands are active catalysts for the reduction of protons to H2 at potentials as positive as -0.28 V vs. SCE.	Hydrogen	159-161	forkhead box G1	Homo sapiens	75-78
15993078-4	2005	Compounds having 5-anilino substituent exhibit high potency with 5-(4-methoxy)anilino-4-hydroxy-8-nitroquinazoline (1h) being the best dual EGFR/ErbB-2 inhibitors, which effectively inhibited the growth of both EGFR (MDA-MB-468, IC(50)&lt;0.01microM) and ErbB-2 (SK-BR-3, IC(50)=13microM) overexpressing human tumor cell lines in vitro.	Hydrogen	116-118	epidermal growth factor receptor	Homo sapiens	140-144
15993078-4	2005	Compounds having 5-anilino substituent exhibit high potency with 5-(4-methoxy)anilino-4-hydroxy-8-nitroquinazoline (1h) being the best dual EGFR/ErbB-2 inhibitors, which effectively inhibited the growth of both EGFR (MDA-MB-468, IC(50)&lt;0.01microM) and ErbB-2 (SK-BR-3, IC(50)=13microM) overexpressing human tumor cell lines in vitro.	Hydrogen	116-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	145-151
15993078-4	2005	Compounds having 5-anilino substituent exhibit high potency with 5-(4-methoxy)anilino-4-hydroxy-8-nitroquinazoline (1h) being the best dual EGFR/ErbB-2 inhibitors, which effectively inhibited the growth of both EGFR (MDA-MB-468, IC(50)&lt;0.01microM) and ErbB-2 (SK-BR-3, IC(50)=13microM) overexpressing human tumor cell lines in vitro.	Hydrogen	116-118	epidermal growth factor receptor	Homo sapiens	211-215
15993078-4	2005	Compounds having 5-anilino substituent exhibit high potency with 5-(4-methoxy)anilino-4-hydroxy-8-nitroquinazoline (1h) being the best dual EGFR/ErbB-2 inhibitors, which effectively inhibited the growth of both EGFR (MDA-MB-468, IC(50)&lt;0.01microM) and ErbB-2 (SK-BR-3, IC(50)=13microM) overexpressing human tumor cell lines in vitro.	Hydrogen	116-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	255-261
16162005-6	2005	Substitution of the indole N-1 position with methyl or ethyl groups gave a 10- to 30-fold decrease in affinity for hSERT, suggesting either a hydrogen-bonding interaction or limited steric tolerance in the region of the indole nitrogen.	Hydrogen	142-150	solute carrier family 6 member 4	Homo sapiens	115-120
16080154-5	2005	Comparison with the crystal structure of bovine common-type AcP and that of D. melanogaster AcP (AcPDro2) as representative of eukaryotic AcP revealed some significant characteristics in P. horikoshii AcP that likely play important roles in structural stability: (1) shortening of the flexible N-terminal region and long loop; (2) an increased number of ion pairs on the protein surface; (3) stabilization of the loop structure by hydrogen bonds.	Hydrogen	431-439	Acylphosphatase 2	Drosophila melanogaster	60-63
16080154-5	2005	Comparison with the crystal structure of bovine common-type AcP and that of D. melanogaster AcP (AcPDro2) as representative of eukaryotic AcP revealed some significant characteristics in P. horikoshii AcP that likely play important roles in structural stability: (1) shortening of the flexible N-terminal region and long loop; (2) an increased number of ion pairs on the protein surface; (3) stabilization of the loop structure by hydrogen bonds.	Hydrogen	431-439	Acylphosphatase 2	Drosophila melanogaster	92-95
16080154-5	2005	Comparison with the crystal structure of bovine common-type AcP and that of D. melanogaster AcP (AcPDro2) as representative of eukaryotic AcP revealed some significant characteristics in P. horikoshii AcP that likely play important roles in structural stability: (1) shortening of the flexible N-terminal region and long loop; (2) an increased number of ion pairs on the protein surface; (3) stabilization of the loop structure by hydrogen bonds.	Hydrogen	431-439	Acylphosphatase 2	Drosophila melanogaster	97-104
16080154-5	2005	Comparison with the crystal structure of bovine common-type AcP and that of D. melanogaster AcP (AcPDro2) as representative of eukaryotic AcP revealed some significant characteristics in P. horikoshii AcP that likely play important roles in structural stability: (1) shortening of the flexible N-terminal region and long loop; (2) an increased number of ion pairs on the protein surface; (3) stabilization of the loop structure by hydrogen bonds.	Hydrogen	431-439	Acylphosphatase 2	Drosophila melanogaster	92-95
16080154-5	2005	Comparison with the crystal structure of bovine common-type AcP and that of D. melanogaster AcP (AcPDro2) as representative of eukaryotic AcP revealed some significant characteristics in P. horikoshii AcP that likely play important roles in structural stability: (1) shortening of the flexible N-terminal region and long loop; (2) an increased number of ion pairs on the protein surface; (3) stabilization of the loop structure by hydrogen bonds.	Hydrogen	431-439	Acylphosphatase 2	Drosophila melanogaster	92-95
16173715-1	2005	We studied the interaction of mono- and polyunsaturated phosphatidylcholines with rhodopsin by 1H NMR saturation transfer difference spectroscopy with magic angle spinning (STD-MAS NMR).	Hydrogen	95-97	rhodopsin	Homo sapiens	82-91
16028301-3	2005	The experiment was validated by using the E140Q mutant of the C-terminal fragment of calmodulin, which exhibits significant conformational exchange between two major conformations, as gauged from previous 15N and 1H relaxation studies.	Hydrogen	213-215	calmodulin 1	Homo sapiens	85-95
16834202-1	2005	The hydrogen abstraction reaction of the OH radical with CH(3)CHF(2) (HFC152-a) has been studied theoretically over a wide temperature range, 200-3000 K. Two different reactive sites of the molecule, CH(3) and CHF(2) groups have been investigated precisely, and results confirm that CHF(2) position of the molecule is a highly reactive site.	Hydrogen	4-12	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	62-67
16834202-1	2005	The hydrogen abstraction reaction of the OH radical with CH(3)CHF(2) (HFC152-a) has been studied theoretically over a wide temperature range, 200-3000 K. Two different reactive sites of the molecule, CH(3) and CHF(2) groups have been investigated precisely, and results confirm that CHF(2) position of the molecule is a highly reactive site.	Hydrogen	4-12	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	210-215
16834202-1	2005	The hydrogen abstraction reaction of the OH radical with CH(3)CHF(2) (HFC152-a) has been studied theoretically over a wide temperature range, 200-3000 K. Two different reactive sites of the molecule, CH(3) and CHF(2) groups have been investigated precisely, and results confirm that CHF(2) position of the molecule is a highly reactive site.	Hydrogen	4-12	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	210-215
16159120-7	2005	Having a means, such as HOST, for automating the interpretation of the MSn data generated from glycosaminoglycans, provides a practical methodology for the future analysis of heparin/HS oligosaccharides of unknown structure.	Hydrogen	183-185	moesin	Homo sapiens	71-74
16134934-2	2005	Comparison with the hALR2-fidarestat complex and the porcine aldehyde reductase (ALR1)-fidarestat complex indicates that the hydrogen bond between the Leu300 amino group of the wild-type and the exocyclic amide group of the inhibitor is the key determinant for the specificity of fidarestat for ALR2 over ALR1.	Hydrogen	125-133	aldo-keto reductase family 1 member B	Homo sapiens	20-25
16134934-2	2005	Comparison with the hALR2-fidarestat complex and the porcine aldehyde reductase (ALR1)-fidarestat complex indicates that the hydrogen bond between the Leu300 amino group of the wild-type and the exocyclic amide group of the inhibitor is the key determinant for the specificity of fidarestat for ALR2 over ALR1.	Hydrogen	125-133	aldo-keto reductase family 1 member B	Homo sapiens	21-25
16134934-5	2005	Thus, the hydrogen bond ( approximately 7 kJ/mol) corresponds to a 23-fold difference in inhibitor potency while the differences in the interactions between Trp219(ALR2) and fidarestat and between Trp220(ALR1) and fidarestat can account for an additional 10-fold difference in potency.	Hydrogen	10-18	aldo-keto reductase family 1 member B	Homo sapiens	164-168
16124797-1	2005	Insertion of CS2 into one of the Ir-H bonds of [Ir(H)5(PCy3)2] takes place to afford the dihydrido dithioformate complex cis-[Ir(H)2(eta2-S2CH)(PCy3)2] accompanied by the elimination of H2.	Hydrogen	186-188	chorionic somatomammotropin hormone 2	Homo sapiens	13-16
15980167-0	2005	Hydrogen bonding dynamics during protein folding of reduced cytochrome c: temperature and denaturant concentration dependence.	Hydrogen	0-8	cytochrome c, somatic	Homo sapiens	60-72
15972816-5	2005	In a mutation study of mouse CYP27B1 that included spectroscopic analysis, we concluded that in a 1alpha-hydroxylation process, Ser408 of mouse CYP27B1 corresponding to Thr409 of human CYP27B1 forms a hydrogen bond with the 25-hydroxyl group of 25-hydroxyvitamin D3.	Hydrogen	201-209	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	29-36
16061068-11	2005	After 1h recovery, a significant increase in the POMC mRNA expression was detected (2.44-fold, P&lt;0.05) followed by a decline 2h later (1.52-fold) when the experiment was terminated.	Hydrogen	6-8	proopiomelanocortin	Homo sapiens	49-53
16116080-0	2005	A funneled energy landscape for cytochrome c directly predicts the sequential folding route inferred from hydrogen exchange experiments.	Hydrogen	106-114	cytochrome c, somatic	Homo sapiens	32-44
16116080-4	2005	The results show the importance of the heme as a nucleation site and explain the observed hydrogen exchange patterns of cytochrome c within the context of energy landscape theory.	Hydrogen	90-98	cytochrome c, somatic	Homo sapiens	120-132
16190251-8	2005	The mixture obtained (71% H2: 23% CH4) could be used as a hydrogen source to obtain pure hydrogen or hydrogen-natural gas mixtures to fuel a captive fleet of public urban vehicles powered by fuel cells or dedicated ICE, respectively.	Hydrogen	58-66	carboxylesterase 2	Homo sapiens	215-218
16154093-5	2005	The presence of RelB-specific nonpolar residues at the surface removes several intradomain surface hydrogen bonds that may render the domain fold unstable.	Hydrogen	99-107	RELB proto-oncogene, NF-kB subunit	Homo sapiens	16-20
15972816-5	2005	In a mutation study of mouse CYP27B1 that included spectroscopic analysis, we concluded that in a 1alpha-hydroxylation process, Ser408 of mouse CYP27B1 corresponding to Thr409 of human CYP27B1 forms a hydrogen bond with the 25-hydroxyl group of 25-hydroxyvitamin D3.	Hydrogen	201-209	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	144-151
15972816-5	2005	In a mutation study of mouse CYP27B1 that included spectroscopic analysis, we concluded that in a 1alpha-hydroxylation process, Ser408 of mouse CYP27B1 corresponding to Thr409 of human CYP27B1 forms a hydrogen bond with the 25-hydroxyl group of 25-hydroxyvitamin D3.	Hydrogen	201-209	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	144-151
16101294-0	2005	IL-1beta epitope mapping using site-directed mutagenesis and hydrogen-deuterium exchange mass spectrometry analysis.	Hydrogen	61-69	interleukin 1 beta	Mus musculus	0-8
16045931-0	2005	Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry.	Hydrogen	86-94	arrestin beta 1	Homo sapiens	35-44
16107153-3	2005	In aldose reductase, Leu300 forms a hydrogen bond through its main-chain nitrogen atom with the exocyclic amide group of the inhibitor, which when replaced with a Pro in aldehyde reductase, cannot form a hydrogen bond, thus causing a loss in binding energy.	Hydrogen	36-44	aldo-keto reductase family 1 member B	Homo sapiens	3-19
16107153-3	2005	In aldose reductase, Leu300 forms a hydrogen bond through its main-chain nitrogen atom with the exocyclic amide group of the inhibitor, which when replaced with a Pro in aldehyde reductase, cannot form a hydrogen bond, thus causing a loss in binding energy.	Hydrogen	204-212	aldo-keto reductase family 1 member B	Homo sapiens	3-19
16101294-9	2005	Hydrogen-deuterium exchange/mass spectrometry analysis confirmed that these regions of IL-1beta were protected from exchange because of antibody binding.	Hydrogen	0-8	interleukin 1 beta	Mus musculus	87-95
16101277-5	2005	Several hydrogen bonds and salt bridges that stabilize the BRCA1-BACH1 complex are missing in the BRCA1-CtIP interaction, offering a structural basis for the approximately 5-fold lower affinity of BRCA1 for CtIP compared to that of BACH1, as determined by isothermal titration calorimetry.	Hydrogen	8-16	BTB domain and CNC homolog 1	Homo sapiens	65-70
16060675-4	2005	Such side chain hydrogen bonding interactions have been called "polar zippers" by M. F. Perutz and have been proposed to stabilize amyloid fibrils formed by peptides with glutamine- and asparagine-rich sequences, such as Ure2p(10)(-)(39).	Hydrogen	16-24	glutathione peroxidase	Saccharomyces cerevisiae S288C	221-226
16108094-7	2005	The affinity of ligands with AChE was found to be the cumulative effects of number of hydrophobic contacts and hydrogen bonding.	Hydrogen	111-119	acetylcholinesterase (Cartwright blood group)	Homo sapiens	29-33
16022504-7	2005	This result confirmed formation of 3-pronged hydrogen bonds for the oxyanion hole of butyrylcholinesterase and 2-pronged hydrogen bonds for the oxyanion hole of acetylcholinesterase.	Hydrogen	45-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	161-181
15899884-4	2005	The expression of SNAT3 protein was detected on the plasma membrane of hepatocyte-like H2.35 cells with a half-life of 6-8 h. When H2.35 cells were depleted of serum, the expression of SNAT3 was increased.	Hydrogen	87-89	solute carrier family 38 member 3	Homo sapiens	18-23
16022504-7	2005	This result confirmed formation of 3-pronged hydrogen bonds for the oxyanion hole of butyrylcholinesterase and 2-pronged hydrogen bonds for the oxyanion hole of acetylcholinesterase.	Hydrogen	121-129	acetylcholinesterase (Cartwright blood group)	Homo sapiens	161-181
15943472-4	2005	From a lead methyl ester, investigation of five-membered heteroaromatic substituents at C-4 produced a 3-pyrazolyl analogue that improved activity by making a targeted hydrogen bond with Trp178.	Hydrogen	168-176	complement C4A	Rattus norvegicus	88-91
16132828-0	2005	1H, 15N, and 13C resonance assignments of human interleukin-2.	Hydrogen	0-2	interleukin 2	Homo sapiens	48-61
16132832-0	2005	1H, 13C and 15N resonance assignments of a Bcl-xL/Bad peptide complex.	Hydrogen	0-2	BCL2 like 1	Homo sapiens	43-49
15974586-0	2005	Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity.	Hydrogen	63-71	checkpoint kinase 1	Homo sapiens	32-36
15962987-7	2005	The influence of the equatorial glyoxime ligand was also investigated and the capability of the stabilized BF2-bridged species [Co(dmgBF2)2(OH2)2] for electrocatalyzed hydrogen evolution confirmed.	Hydrogen	168-176	forkhead box G1	Homo sapiens	107-110
15919078-3	2005	The resonance Raman spectrum provides evidence for a strongly hydrogen-bonded Schiff base like in mammalian rhodopsin but unlike to the homologous pSRII from Natronobacterium pharaonis.	Hydrogen	62-70	rhodopsin	Homo sapiens	108-117
15835884-4	2005	Here we report that UDG kinetically and thermodynamically prefers substrate sites where the uracil is paired with an unnatural adenine analogue that lacks any Watson-Crick hydrogen-bonding groups.	Hydrogen	172-180	uracil DNA glycosylase	Homo sapiens	20-23
16090320-1	2005	Chiral SU(3) effective field theory in combination with a relativistic coupled-channels approach is used to perform a novel analysis of the strong-interaction shift and width in kaonic hydrogen in view of the new accurate DEAR measurements.	Hydrogen	185-193	FBXW7 antisense RNA 1	Homo sapiens	222-226
16034671-0	2005	1H, 13C and 15N resonance assignments of the backbone and methyl groups of the 24 kDa tetratricopeptide repeat domain in p67(phox).	Hydrogen	0-2	CD33 molecule	Homo sapiens	121-124
16034673-0	2005	Backbone 1H, 13C, and 15N assignments of a 56 kDa E. coli nickel binding protein NikA.	Hydrogen	9-11	relaxosome component	Escherichia coli	81-85
15917086-3	2005	Tyr325 is at the second coordination sphere, hydrogen-bonded to water (wat1).	Hydrogen	45-53	MTOR associated protein, LST8 homolog	Homo sapiens	71-75
15945742-2	2005	CuH(2) and AuH(2) have been recently observed by IR spectroscopy in solid hydrogen and bending anharmonic wave numbers have been assigned to these two systems.	Hydrogen	74-82	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	11-14
15885426-2	2005	Experimental results indicated that amino functional groups on the polymeric matrix play an important role in phenol adsorption by MCH-111 and ND-900, which was attributed to the formation of hydrogen bonding between the phenol molecule and the amino group on the polymeric matrix.	Hydrogen	192-200	pro-melanin concentrating hormone	Homo sapiens	131-134
15610065-3	2005	In the model structure of CAR, Thr176 constitutes a part of the ligand-binding surface, but its side chain is not directed toward the surface, instead it forms a hydrogen bond with Thr350 in the AF2 (activation function 2) domain of CAR.	Hydrogen	162-170	nuclear receptor subfamily 1, group I, member 3	Mus musculus	26-29
15845357-9	2005	Although the overall structures of the three enzymes are quite similar to each other, some subtle difference around their active sites that distinguishes cathepsin-E from cathepsin-D and BACE1 has been revealed through an analysis of hydrogen bond network and microenvironment.	Hydrogen	234-242	beta-secretase 1	Homo sapiens	187-192
15883377-8	2005	The CLC-Abeta aggregates exhibit the same protection from hydrogen-deuterium exchange as do protofibrils isolated from a spontaneous Abeta fibril formation reaction: approximately 12 of the 39 Abeta(1-40) backbone amide protons are protected from exchange in the protofibril, compared with approximately twice that number in amyloid fibrils.	Hydrogen	58-66	amyloid beta precursor protein	Homo sapiens	8-13
15869258-1	2005	The butyl urea of guanosine (UG) presents an ADDA hydrogen-bonding array that is complementary to the DAAD array of 2,7-diamido-1,8-naphthyridine (DAN).	Hydrogen	50-58	adducin 1	Homo sapiens	45-49
15565311-5	2005	1H MR spectroscopy (MRS) has mainly been used to describe neuronal damage represented by decreased NAA (6.4 mmol vs. 9 mmol) and Cr/PCr (7.0 mmol vs. 9.8 mmol) concentrations in the basal ganglia region of the patient group to controls; MRS is much more case-sensitive and describes individual development of the disease as demonstrated in the difference between the spectra of typical PKAN patients (1, 2), and the patient (3) with atypical PKAN development.	Hydrogen	0-2	pantothenate kinase 2	Homo sapiens	386-390
15565311-5	2005	1H MR spectroscopy (MRS) has mainly been used to describe neuronal damage represented by decreased NAA (6.4 mmol vs. 9 mmol) and Cr/PCr (7.0 mmol vs. 9.8 mmol) concentrations in the basal ganglia region of the patient group to controls; MRS is much more case-sensitive and describes individual development of the disease as demonstrated in the difference between the spectra of typical PKAN patients (1, 2), and the patient (3) with atypical PKAN development.	Hydrogen	0-2	pantothenate kinase 2	Homo sapiens	442-446
15808862-5	2005	Pim1 is unique among protein kinases due to the presence of a proline residue at position 123 that precludes the formation of the canonical second hydrogen bond between the hinge backbone and the adenine moiety of ATP.	Hydrogen	147-155	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
15840385-9	2005	Comparisons of the conformational characteristics among CTr and its two analogs indicated that the estrogenic effects of CTr are highly sensitive to apparently minor structural modifications, and further supported the hypothesis for a central role of hydrogen bonding around the nitrogen atom in CTr binding to the ligand binding site of ERalpha.	Hydrogen	251-259	calcitonin receptor	Homo sapiens	56-59
16833683-7	2005	This provides a framework to interpret the differences observed in the TR3 spectral and triplet lifetime obtained in the neat MeCN solvent (attributed to the free MAP triplet state) and the 50% H2O/50% MeCN solvent (due to the triplet of the hydrogen-bond complex).	Hydrogen	242-250	nuclear receptor subfamily 4 group A member 1	Homo sapiens	71-74
15840385-9	2005	Comparisons of the conformational characteristics among CTr and its two analogs indicated that the estrogenic effects of CTr are highly sensitive to apparently minor structural modifications, and further supported the hypothesis for a central role of hydrogen bonding around the nitrogen atom in CTr binding to the ligand binding site of ERalpha.	Hydrogen	251-259	calcitonin receptor	Homo sapiens	121-124
15840385-9	2005	Comparisons of the conformational characteristics among CTr and its two analogs indicated that the estrogenic effects of CTr are highly sensitive to apparently minor structural modifications, and further supported the hypothesis for a central role of hydrogen bonding around the nitrogen atom in CTr binding to the ligand binding site of ERalpha.	Hydrogen	251-259	calcitonin receptor	Homo sapiens	121-124
15807533-0	2005	Evidence for hydrogen bond formation to the PsaB chlorophyll of P700 in photosystem I mutants of Synechocystis sp.	Hydrogen	13-21	fatty acid amide hydrolase	Homo sapiens	44-48
19787985-4	2005	There has been a controversial discussion about an experiment which seemed to indicate that deuteron transfer from CD4+ to CH4 can create stable isotopomers with chemically distinguishable hydrogen atoms, CH3-HD+.	Hydrogen	189-197	CD4 molecule	Homo sapiens	115-118
15769471-0	2005	Changes in interhelical hydrogen bonding upon rhodopsin activation.	Hydrogen	24-32	rhodopsin	Homo sapiens	46-55
15769471-1	2005	Hydrogen bonding interactions between transmembrane helices stabilize the visual pigment rhodopsin in an inactive conformation in the dark.	Hydrogen	0-8	rhodopsin	Homo sapiens	89-98
15769471-2	2005	The crystal structure of rhodopsin has previously revealed that Glu122 and Trp126 on transmembrane helix H3 form a complex hydrogen bonding network with Tyr206 and His211 on H5, while the indole nitrogen of Trp265 on H6 forms a water-mediated hydrogen bond with Asn302 on H7.	Hydrogen	123-131	rhodopsin	Homo sapiens	25-34
15769471-2	2005	The crystal structure of rhodopsin has previously revealed that Glu122 and Trp126 on transmembrane helix H3 form a complex hydrogen bonding network with Tyr206 and His211 on H5, while the indole nitrogen of Trp265 on H6 forms a water-mediated hydrogen bond with Asn302 on H7.	Hydrogen	243-251	rhodopsin	Homo sapiens	25-34
15769471-3	2005	Here, we use solid-state magic angle spinning NMR spectroscopy to probe the changes in hydrogen bonding upon rhodopsin activation.	Hydrogen	87-95	rhodopsin	Homo sapiens	109-118
15769471-4	2005	The NMR chemical shifts of 15N-labeled tryptophan are consistent with the indole nitrogens of Trp126 and Trp265 becoming more weakly hydrogen bonded between rhodopsin and metarhodopsin II.	Hydrogen	133-141	rhodopsin	Homo sapiens	157-166
15769471-6	2005	Moreover, measurements of rhodopsin containing 13C-labeled histidine show that a strong hydrogen bond between the side-chain of Glu122 and the backbone carbonyl of His211 is disrupted in metarhodopsin II.	Hydrogen	88-96	rhodopsin	Homo sapiens	26-35
15934890-1	2005	Insulin glulisine (Apidra, Sanofi-Aventis), a new and recently approved rapid-acting insulin analogue, mimics the pharmacokinetic and pharmacodynamic profiles of physiological human insulin, but has a rapid onset, peak effect at 1h, and a shorter duration of action (approximately 4 h).	Hydrogen	229-231	insulin	Homo sapiens	0-7
15780605-0	2005	QSAR-by-NMR: quantitative insights into structural determinants for binding affinity by analysis of 1H/15N chemical shift differences in MMP-3 ligands.	Hydrogen	100-102	matrix metallopeptidase 3	Homo sapiens	137-142
15699454-2	2005	The alkalosis-generating effect of angiotensin II is usually ascribed to its stimulatory effect on aldosterone secretion, a hormone that upregulates collecting duct hydrogen ion secretion.	Hydrogen	165-173	angiotensinogen	Rattus norvegicus	35-49
15699454-12	2005	By increasing the relative abundance of the B1 subunit of H+-ATPase in the collecting duct, angiotensin II excess may lead to increased hydrogen ion secretion and thus metabolic alkalosis-a common feature of hypertensive syndromes associated with angiotensin II overactivity.	Hydrogen	136-144	angiotensinogen	Rattus norvegicus	92-106
15929007-0	2005	Assignment of the 1H, 13C and 15N resonances of Mlc1p from Saccharomices cerevisiae.	Hydrogen	18-20	modulator of VRAC current 1	Homo sapiens	48-53
15787563-5	2005	The second photoreaction process is photocyclization of cis-BSF, which occurs to give DP1 decaying with the half lifetime (tau1/2) of 2.8-4.0 micros to produce another DHP-type intermediate (DP2) with an absorption peak at 400 nm in the absence of O2, through [1,9]-hydrogen shift.	Hydrogen	266-274	transcription factor Dp-1	Homo sapiens	86-89
15787563-7	2005	In O2-saturated CH2Cl2, DP1 decayed with tau1/2 = 250 ns to give a radical intermediate (X) with two peaks at 410 and 510 nm, through hydrogen abstraction of DP1 by O2.	Hydrogen	134-142	transcription factor Dp-1	Homo sapiens	24-27
15787563-7	2005	In O2-saturated CH2Cl2, DP1 decayed with tau1/2 = 250 ns to give a radical intermediate (X) with two peaks at 410 and 510 nm, through hydrogen abstraction of DP1 by O2.	Hydrogen	134-142	transcription factor Dp-1	Homo sapiens	158-161
15783171-3	2005	Isotopic perturbation of resonance (IPR) experiments, conducted on several isotopomers of (i-PrCp)Re(CO)2(1-pentane), showed a large shielding of the 1H NMR chemical shift of the proton in a bound CHD2 moiety (delta -3.62) and CH2D (delta -2.64) compared with that of a bound CH3 moiety (delta -1.99).	Hydrogen	150-152	PPARG related coactivator 1	Homo sapiens	93-97
15698891-5	2005	ERK-like activation was found 1h after spaced training in cytosolic but not in nuclear fractions of brain homogenates, while JNK activity remained unchanged in both fractions.	Hydrogen	30-32	mitogen-activated protein kinase 1	Homo sapiens	0-3
15698891-8	2005	These data support that: (1) cytoplasmic but not nuclear ERK substrates must be differentially phosphorylated during memory consolidation, and (2) ERK phosphorylation and consequent activation 1h after training is necessary for long-term memory consolidation in this arthropod model.	Hydrogen	193-195	mitogen-activated protein kinase 1	Homo sapiens	147-150
15779901-0	2005	Unusual four-bond secondary H/D isotope effect supports a short-strong hydrogen bond between phospholipase A2 and a transition state analogue inhibitor.	Hydrogen	71-79	phospholipase A2 group IB	Homo sapiens	93-109
15768036-0	2005	19F and 1H MRI detection of amyloid beta plaques in vivo.	Hydrogen	8-10	amyloid beta precursor protein	Homo sapiens	28-40
15774579-1	2005	Equilibrium and kinetic hydrogen exchange experiments show that cytochrome c is composed of five foldon units that continually unfold and refold even under native conditions.	Hydrogen	24-32	cytochrome c, somatic	Homo sapiens	64-76
15771442-19	2005	The X-ray crystal structures of the ternary complexes 3-thrombin-hirugen and 4-thrombin-hirugen depict novel interactions in the S(1)" region, with the benzothiazole ring forming a hydrogen bond with His-57 and an aromatic stacking interaction with Trp-60D of thrombin"s insertion loop.	Hydrogen	181-189	coagulation factor II, thrombin	Homo sapiens	79-87
15771442-19	2005	The X-ray crystal structures of the ternary complexes 3-thrombin-hirugen and 4-thrombin-hirugen depict novel interactions in the S(1)" region, with the benzothiazole ring forming a hydrogen bond with His-57 and an aromatic stacking interaction with Trp-60D of thrombin"s insertion loop.	Hydrogen	181-189	coagulation factor II, thrombin	Homo sapiens	56-64
15771442-19	2005	The X-ray crystal structures of the ternary complexes 3-thrombin-hirugen and 4-thrombin-hirugen depict novel interactions in the S(1)" region, with the benzothiazole ring forming a hydrogen bond with His-57 and an aromatic stacking interaction with Trp-60D of thrombin"s insertion loop.	Hydrogen	181-189	coagulation factor II, thrombin	Homo sapiens	79-87
15836222-1	2005	In the 2500-8500 cm(-1) region several strong emission bands of (40)ArH were observed by Fourier transform spectroscopy through a dc glow discharge in a mixture of argon and hydrogen.	Hydrogen	174-182	low density lipoprotein receptor adaptor protein 1	Homo sapiens	68-71
15733928-11	2005	Interestingly, the hydrogen bonding interactions at the first oxyanion hole are different in thiolase and KAS I.	Hydrogen	19-27	3-oxoacyl-ACP synthase, mitochondrial	Homo sapiens	106-111
15733928-12	2005	In KAS I, the hydrogen bonding partners are two histidine NE2 atoms, instead of a water and a NE2 side-chain atom in thiolase.	Hydrogen	14-22	3-oxoacyl-ACP synthase, mitochondrial	Homo sapiens	3-8
15727869-5	2005	The structure-activity relationships of these naphthols analyzed by docking experiments, indicated that the presence of hydroxyl group at C-1 position on the naphthalene nucleus enhanced the anti-inflammatory activity towards COX-2 via hydrogen bonding to the COX-2 Val 523 side chain.	Hydrogen	236-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-231
15727869-5	2005	The structure-activity relationships of these naphthols analyzed by docking experiments, indicated that the presence of hydroxyl group at C-1 position on the naphthalene nucleus enhanced the anti-inflammatory activity towards COX-2 via hydrogen bonding to the COX-2 Val 523 side chain.	Hydrogen	236-244	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	260-265
15731882-7	2005	Based on 19F NMR, we speculate that they inactivate the enzymes as a result of the formation of hydrogen-bonds between fluorine atoms of the inhibitors and the serine protease.	Hydrogen	96-104	coagulation factor II, thrombin	Homo sapiens	160-175
16851415-2	2005	Mechanically milled mixtures of LiBH4 + (1/2)MgH2 or LiH + (1/2)MgB2 including 2-3 mol % TiCl3 are shown to reversibly store 8-10 wt % hydrogen.	Hydrogen	135-143	secretoglobin family 2A member 1	Homo sapiens	64-68
15807509-7	2005	The results suggest that hydrogen bonding to Gln285 is indispensable for PXR activation.	Hydrogen	25-33	nuclear receptor subfamily 1 group I member 2	Homo sapiens	73-76
15760676-1	2005	We have previously demonstrated that treatment of the human keratinocyte cell line NCTC 2544 with a UVB dose equivalent to 1h exposure (100 mJ/cm2) results in a significant increase of IL-8 production.	Hydrogen	123-125	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
15799475-0	2005	C-H...O hydrogen bonds in cyclohexenone reveal the spectroscopic behavior of Csp3-H and Csp2-H donors.	Hydrogen	8-16	regulator of calcineurin 2	Homo sapiens	88-92
15732990-2	2005	The complexes are generally characterized by elemental analysis, 31P{1H} NMR, 1H NMR, and IR spectroscopies, and MS. X-ray analysis of three PPh3 complexes reveals chelation of E-semicarbazones by the imine-N atom and the carbonyl-O atom.	Hydrogen	69-71	caveolin 1	Homo sapiens	141-145
15732990-2	2005	The complexes are generally characterized by elemental analysis, 31P{1H} NMR, 1H NMR, and IR spectroscopies, and MS. X-ray analysis of three PPh3 complexes reveals chelation of E-semicarbazones by the imine-N atom and the carbonyl-O atom.	Hydrogen	78-80	caveolin 1	Homo sapiens	141-145
15738997-4	2005	The remarkably large proton-dissociation rate in 1,8-DAN can be ascribed to its larger reaction exergonicity which results from the electrostatic repulsion between the two ammonium groups in the reactant (the dication state) and the stabilization of the monocation state due to hydrogen bonding interactions between the NH3+ and NH2 moieties.	Hydrogen	278-286	NBL1, DAN family BMP antagonist	Homo sapiens	53-56
15525646-7	2005	2) The hinge region has a novel architecture and hydrogen-bonding pattern, which not only expand the ATP pocket but also serve to establish unambiguously the alignment of the Pim-1 hinge region with that of other kinases.	Hydrogen	49-57	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	175-180
15713462-3	2005	Hydrogen/deuterium exchange experiments monitored by NMR and mass spectrometry reveal that, despite their different locations and the different effects of the two mutations on the structure of the native state of lysozyme, both mutations cause a cooperative destabilisation of a remarkably similar segment of the structure, comprising in both cases the beta-domain and the adjacent C-helix.	Hydrogen	0-8	lysozyme	Homo sapiens	213-221
15683794-2	2005	The water monomers weakly hydrogen bonded with NO3- ions showed a positive peak near at 3565 cm(-1) for both Mg(NO3)2 and NH4NO3 solutions.	Hydrogen	26-34	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
15683794-2	2005	The water monomers weakly hydrogen bonded with NO3- ions showed a positive peak near at 3565 cm(-1) for both Mg(NO3)2 and NH4NO3 solutions.	Hydrogen	26-34	NBL1, DAN family BMP antagonist	Homo sapiens	112-115
15683794-4	2005	Compared with perchlorate solutions, the positive peak of nitrate solutions has a red shift of about 20 cm(-1) and the peak area is about half of that of perchlorate solutions with the same concentrations, indicating that the hydrogen bonding between NO3- and water monomers is relative stronger than that between ClO4- and water monomers, and NO3- has a strict requirement on the orientation of water molecules when hydrogen bonded with water monomers due to its planar structure.	Hydrogen	226-234	NBL1, DAN family BMP antagonist	Homo sapiens	251-254
15683794-4	2005	Compared with perchlorate solutions, the positive peak of nitrate solutions has a red shift of about 20 cm(-1) and the peak area is about half of that of perchlorate solutions with the same concentrations, indicating that the hydrogen bonding between NO3- and water monomers is relative stronger than that between ClO4- and water monomers, and NO3- has a strict requirement on the orientation of water molecules when hydrogen bonded with water monomers due to its planar structure.	Hydrogen	226-234	NBL1, DAN family BMP antagonist	Homo sapiens	344-347
15683794-4	2005	Compared with perchlorate solutions, the positive peak of nitrate solutions has a red shift of about 20 cm(-1) and the peak area is about half of that of perchlorate solutions with the same concentrations, indicating that the hydrogen bonding between NO3- and water monomers is relative stronger than that between ClO4- and water monomers, and NO3- has a strict requirement on the orientation of water molecules when hydrogen bonded with water monomers due to its planar structure.	Hydrogen	417-425	NBL1, DAN family BMP antagonist	Homo sapiens	251-254
15689157-6	2005	Fisetin binds to the active form of CDK6, forming hydrogen bonds with the side chains of residues in the binding pocket that undergo large conformational changes during CDK activation by cyclin binding.	Hydrogen	50-58	cyclin dependent kinase 6	Homo sapiens	36-40
15710387-5	2005	Finally, an investigation of the enzymatic hydrolysis of a synthetic substrate, 4-methylumbelliferyl N-acetyl-alpha-D-neuraminide, by 1H NMR spectroscopy revealed that the reaction catalysed by rat skeletal muscle cytosolic sialidase proceeds with overall retention of anomeric configuration.	Hydrogen	134-136	neuraminidase 2	Rattus norvegicus	214-233
15743219-3	2005	Calculations based on this method afford magneto-optical rotations of the right magnitude for the molecules H2, N2, CO, HF, CH4, C2H2, H2O, and CS2.	Hydrogen	108-110	chorionic somatomammotropin hormone 2	Homo sapiens	144-147
15653338-4	2005	In fact, the importance for the A3 receptor-ligand interaction of both a strong acidic NH proton donor and a C=O proton acceptor at position-4, able to engage hydrogen-bonding interactions with specific sites on the A3 AR, has been confirmed.	Hydrogen	159-167	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	32-34
15683244-3	2005	An FTIR study estimated an energy of -0.88 kcal/mol for the G79-C(alpha)-H...I76-O hydrogen bond in glycophorin A, whereas a mutagenesis study showed that the A51-C(alpha)-H...T24-O(gamma) hydrogen bond does not stabilize bacteriorhodopsin.	Hydrogen	83-91	glycophorin A (MNS blood group)	Homo sapiens	100-113
15683244-3	2005	An FTIR study estimated an energy of -0.88 kcal/mol for the G79-C(alpha)-H...I76-O hydrogen bond in glycophorin A, whereas a mutagenesis study showed that the A51-C(alpha)-H...T24-O(gamma) hydrogen bond does not stabilize bacteriorhodopsin.	Hydrogen	189-197	glycophorin A (MNS blood group)	Homo sapiens	100-113
15617822-1	2005	Hydrogen exchange rates of the imino protons of the thrombin-binding 15 mer DNA aptamer d(G(1)G(2)T(3)T(4)G(5)G(6)T(7)G(8)T(9)G(10)G(11)T(12)T(13)G(14)G(15)) in the presence of Sr(2+) were measured.	Hydrogen	0-8	coagulation factor II, thrombin	Homo sapiens	52-60
15617822-5	2005	The anti-iminos exchanged faster, but the G(6) imino exchanged slower than other anti-iminos, because its hydrogen bond with the G(10)O6 was stabilized by the TGT loop.	Hydrogen	106-114	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	159-162
15653338-4	2005	In fact, the importance for the A3 receptor-ligand interaction of both a strong acidic NH proton donor and a C=O proton acceptor at position-4, able to engage hydrogen-bonding interactions with specific sites on the A3 AR, has been confirmed.	Hydrogen	159-167	adenosine A3 receptor	Homo sapiens	216-221
15670152-3	2005	In the present study, real-time 1H-NMR spectroscopy showed that the ability of R120G alphaB-crystallin to stabilize the partially folded, molten globule state of alpha-lactalbumin was significantly reduced in comparison with wild-type alphaB-crystallin.	Hydrogen	32-34	lactalbumin alpha	Homo sapiens	162-179
15670725-5	2005	The relative orientation of helix 8 within the CB1 receptor was obtained from intermolecular 31P-1H and 1H-1H NOE measurements.	Hydrogen	97-99	cannabinoid receptor 1	Homo sapiens	47-50
15670725-5	2005	The relative orientation of helix 8 within the CB1 receptor was obtained from intermolecular 31P-1H and 1H-1H NOE measurements.	Hydrogen	104-106	cannabinoid receptor 1	Homo sapiens	47-50
15670725-5	2005	The relative orientation of helix 8 within the CB1 receptor was obtained from intermolecular 31P-1H and 1H-1H NOE measurements.	Hydrogen	104-106	cannabinoid receptor 1	Homo sapiens	47-50
15656623-9	2005	Two mechanisms were previously proposed for iNOS inactivation by L-NIO: (1) uncoupling of the heme peroxide intermediate, leading to destruction of the heme to biliverdin; (2) abstraction of a hydrogen atom from the amidine methyl group followed by attachment to the heme cofactor, which causes the enzyme to catalyze the heme oxygenase reaction.	Hydrogen	193-201	nitric oxide synthase 2	Homo sapiens	44-48
15694771-4	2005	The N-Calpha bond dissociation and transition state energies in charge-stabilized NMA anions are 20-50 kJ mol(-1) greater than in the hydrogen atom adduct.	Hydrogen	134-142	CEA cell adhesion molecule 4	Homo sapiens	4-12
15558556-7	2005	The secondary coactivator peptide forms hydrogen bonds and a hydrophobic core with PPARgamma and the primary coactivator peptide.	Hydrogen	40-48	peroxisome proliferator activated receptor gamma	Homo sapiens	83-92
15598562-3	2005	A molecular modeling (docking) study showed that the p-MeSO2NH group present in (Z)-8d inserts deep inside the 2 degrees-pocket of the COX-2 binding site, it undergoes a hydrophobic interaction with Ala516 and Gly519, and one of the O-atoms of the MeSO2 group participates in a weak hydrogen bonding interaction with the NH2 of Arg513 (distance= 3.85 angstroms).	Hydrogen	283-291	prostaglandin-endoperoxide synthase 2	Homo sapiens	135-140
15567151-5	2005	Furthermore, based on the structural comparison of IGF-1 and insulin, a new assumption was made that in insulin the several hydrogen bonds formed between the N-terminal region of the B-chain and the intra-A-chain disulfide region of the A-chain are the main reason for the stability of the intra-A-chain disulfide bond and for the prevention of disulfide isomerization, while Phe B1 and His B5 are very important for the formation of these hydrogen bonds.	Hydrogen	440-448	insulin like growth factor 1	Homo sapiens	51-56
15516695-8	2005	Computer modeling of the HO-1/CPR complex showed that the guanidino group of Arg(185) is located within the hydrogen bonding distance of 2"-phosphate of NADPH, suggesting that Arg(185) contributes to the binding to CPR through an electrostatic interaction with the phosphate group.	Hydrogen	108-116	cytochrome p450 oxidoreductase	Homo sapiens	30-33
15565726-1	2005	The bow-shaped molecule 1 bearing a self-complementary DAAD-ADDA (D=donor A=acceptor) hydrogen-bonding array generates, in hydrocarbon solvents, highly ordered supramolecular sheet aggregates that subsequently give rise to gels by formation of an entangled network.	Hydrogen	86-94	adducin 1	Homo sapiens	60-64
15567151-5	2005	Furthermore, based on the structural comparison of IGF-1 and insulin, a new assumption was made that in insulin the several hydrogen bonds formed between the N-terminal region of the B-chain and the intra-A-chain disulfide region of the A-chain are the main reason for the stability of the intra-A-chain disulfide bond and for the prevention of disulfide isomerization, while Phe B1 and His B5 are very important for the formation of these hydrogen bonds.	Hydrogen	440-448	insulin	Homo sapiens	61-68
15567147-9	2005	A sharp increase in HIF-1alpha protein levels was induced by hypoxia in CASMC, and 3.5-fold rise of the CRLR protein occurred after 1h of hypoxia in face of unchanged mRNA levels.	Hydrogen	132-134	calcitonin receptor like receptor	Homo sapiens	104-108
15567151-5	2005	Furthermore, based on the structural comparison of IGF-1 and insulin, a new assumption was made that in insulin the several hydrogen bonds formed between the N-terminal region of the B-chain and the intra-A-chain disulfide region of the A-chain are the main reason for the stability of the intra-A-chain disulfide bond and for the prevention of disulfide isomerization, while Phe B1 and His B5 are very important for the formation of these hydrogen bonds.	Hydrogen	440-448	insulin	Homo sapiens	104-111
15567151-5	2005	Furthermore, based on the structural comparison of IGF-1 and insulin, a new assumption was made that in insulin the several hydrogen bonds formed between the N-terminal region of the B-chain and the intra-A-chain disulfide region of the A-chain are the main reason for the stability of the intra-A-chain disulfide bond and for the prevention of disulfide isomerization, while Phe B1 and His B5 are very important for the formation of these hydrogen bonds.	Hydrogen	124-132	insulin like growth factor 1	Homo sapiens	51-56
15567151-5	2005	Furthermore, based on the structural comparison of IGF-1 and insulin, a new assumption was made that in insulin the several hydrogen bonds formed between the N-terminal region of the B-chain and the intra-A-chain disulfide region of the A-chain are the main reason for the stability of the intra-A-chain disulfide bond and for the prevention of disulfide isomerization, while Phe B1 and His B5 are very important for the formation of these hydrogen bonds.	Hydrogen	124-132	insulin	Homo sapiens	61-68
16059664-4	2005	For all COX-2-selective inhibitors under consideration, we find that free energies of binding become less favorable as the receptor changes from COX-2 to COX-1, due to the weakening and/or loss of hydrogen bond and hydrophobic interactions that stabilize the inhibitors in the COX-2 active site.	Hydrogen	197-205	prostaglandin-endoperoxide synthase 2	Homo sapiens	8-13
15567151-5	2005	Furthermore, based on the structural comparison of IGF-1 and insulin, a new assumption was made that in insulin the several hydrogen bonds formed between the N-terminal region of the B-chain and the intra-A-chain disulfide region of the A-chain are the main reason for the stability of the intra-A-chain disulfide bond and for the prevention of disulfide isomerization, while Phe B1 and His B5 are very important for the formation of these hydrogen bonds.	Hydrogen	124-132	insulin	Homo sapiens	104-111
15489307-2	2005	The intermolecular interaction involves stable hydrophobic contacts with a unique protruding CD4-Phe43 structure surrounded by an intermolecular hydrogen-bond network that covers the hemisphere of the CD4 D1 domain.	Hydrogen	145-153	CD4 molecule	Homo sapiens	93-96
15489307-2	2005	The intermolecular interaction involves stable hydrophobic contacts with a unique protruding CD4-Phe43 structure surrounded by an intermolecular hydrogen-bond network that covers the hemisphere of the CD4 D1 domain.	Hydrogen	145-153	CD4 molecule	Homo sapiens	201-204
15762770-3	2005	Mechanism-based inhibition of CYP3A4 is characterised by nicotinamide adenine dinucleotide phosphate hydrogen (NADPH)-, time- and concentration-dependent enzyme inactivation, occurring when some drugs are converted by CYP isoenzymes to reactive metabolites capable of irreversibly binding covalently to CYP3A4.	Hydrogen	101-109	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-36
15762770-3	2005	Mechanism-based inhibition of CYP3A4 is characterised by nicotinamide adenine dinucleotide phosphate hydrogen (NADPH)-, time- and concentration-dependent enzyme inactivation, occurring when some drugs are converted by CYP isoenzymes to reactive metabolites capable of irreversibly binding covalently to CYP3A4.	Hydrogen	101-109	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	303-309
15635182-5	2005	of non-hydrogen free terminal atoms of the molecule have influence on the binding affinity to the estrogen receptor.	Hydrogen	7-15	estrogen receptor 1	Homo sapiens	98-115
15660381-8	2005	Residue Glu 89 in Grb2-SH2 flips inward to fill the binding site and partially replace the phosphate group as a hydrogen-bond acceptor.	Hydrogen	112-120	growth factor receptor bound protein 2	Homo sapiens	18-22
16059664-4	2005	For all COX-2-selective inhibitors under consideration, we find that free energies of binding become less favorable as the receptor changes from COX-2 to COX-1, due to the weakening and/or loss of hydrogen bond and hydrophobic interactions that stabilize the inhibitors in the COX-2 active site.	Hydrogen	197-205	prostaglandin-endoperoxide synthase 2	Homo sapiens	145-150
16059664-4	2005	For all COX-2-selective inhibitors under consideration, we find that free energies of binding become less favorable as the receptor changes from COX-2 to COX-1, due to the weakening and/or loss of hydrogen bond and hydrophobic interactions that stabilize the inhibitors in the COX-2 active site.	Hydrogen	197-205	prostaglandin-endoperoxide synthase 2	Homo sapiens	145-150
15748830-7	2005	These results demonstrated that a higher volume of resistance exercise resulted in down-regulation of AR content 1h post-exercise.	Hydrogen	113-115	androgen receptor	Homo sapiens	102-104
15686538-3	2005	Solvation of (p-methylbenzhydrylamine)copoly(styrene-1% divinylbenzene (DVB) (resin) and resin covalently bound to the fully protected amino acid sequence of CGRP(8-37) (peptide-resin) was correlated to solvent Hildebrand solubility (delta) and hydrogen-bonding (delta(h)) parameters.	Hydrogen	245-253	calcitonin related polypeptide alpha	Homo sapiens	158-162
15475355-0	2004	Role of the retinal hydrogen bond network in rhodopsin Schiff base stability and hydrolysis.	Hydrogen	20-28	rhodopsin	Homo sapiens	45-54
16248107-2	2005	The interaction involving the CBP20 subunit of CBC is mediated by numerous hydrogen bonds and by stacking of the tyrosine sidechains with two first bases of the capped mRNA.	Hydrogen	75-83	nuclear cap binding protein subunit 2	Homo sapiens	30-35
15576569-0	2005	Hydrogen exchange and ligand binding: ligand-dependent and ligand-independent protection in the Src SH3 domain.	Hydrogen	0-8	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	96-99
15576569-4	2005	Here, we examine hydrogen exchange rates in a simple model system, the c-Src SH3 domain interacting with a short peptide ligand.	Hydrogen	17-25	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	73-76
15475355-6	2004	Taken together, our study demonstrates the importance of the retinal hydrogen bond network both in maintaining Schiff base integrity in dark state rhodopsin, as well as in catalyzing the hydrolysis and release of retinal from the MII form.	Hydrogen	69-77	rhodopsin	Homo sapiens	147-156
15496410-4	2004	We searched for these hydrogen bond donors in TM2 by mutating the five polar residues in TM2 of the gamma-aminobutyric acid transporter-1 (GAT1).	Hydrogen	22-30	solute carrier family 6 member 1	Homo sapiens	100-137
15496410-4	2004	We searched for these hydrogen bond donors in TM2 by mutating the five polar residues in TM2 of the gamma-aminobutyric acid transporter-1 (GAT1).	Hydrogen	22-30	solute carrier family 6 member 1	Homo sapiens	139-143
15600341-2	2004	The complexation of ArSH with beta-cyclodextrin was investigated through UV spectral titrations, fluorescence spectroscopy, 1H NMR and molecular simulation, and these results indicated that ArSH fits well to the size of the cavity of beta-cyclodextrin.	Hydrogen	124-126	arylsulfatase family member H	Homo sapiens	20-24
15581354-5	2004	However, due to the lack of hydrogen bonding groups that are required to support an open-to-closed conformational transition in UDG, F cannot stably dock in the UDG active site.	Hydrogen	28-36	uracil DNA glycosylase	Homo sapiens	128-131
15595853-1	2004	Hypoxanthine (Hx) with specific (15)N labels has been used to probe hydrogen-bonding interactions with purine nucleoside phosphorylase (PNP) by NMR spectroscopy.	Hydrogen	68-76	purine nucleoside phosphorylase	Homo sapiens	103-134
15595853-1	2004	Hypoxanthine (Hx) with specific (15)N labels has been used to probe hydrogen-bonding interactions with purine nucleoside phosphorylase (PNP) by NMR spectroscopy.	Hydrogen	68-76	purine nucleoside phosphorylase	Homo sapiens	136-139
15595853-3	2004	In contrast, the (1)H and (15)N chemical shifts of N-1H in the PNP.Hx complex are shifted downfield by 3.5 and 7.5 ppm to 15.9 and 178.8 ppm, respectively, upon binding.	Hydrogen	53-55	purine nucleoside phosphorylase	Homo sapiens	63-66
15595853-8	2004	The observed N-7H chemical shift can be reproduced by a hydrogen bond distance approximately 0.13 A shorter (but within experimental error) of the experimental value found in the X-ray crystal structure of the bovine PNP.Hx complex.	Hydrogen	56-64	purine nucleoside phosphorylase	Homo sapiens	217-220
15383540-10	2004	Furthermore, the crystal structure of the mutant with a restored germ line CDR2 sequence illustrates that the matured hydrophobic core of CDR1 in cAb-Lys3 might be compensated in the germ line precursor by burying solvent molecules engaged in a stable hydrogen-bonding network with CDR1 and CDR2.	Hydrogen	252-260	cerebellar degeneration-related protein 2	Camelus dromedarius	75-79
15585864-9	2004	In the C-terminal arm, key stabilizing contacts are made, including critical hydrogen bonds with Gln(379) in TRAF3 that define the molecular basis for selective binding of BAFF-R solely to this member of the TRAF family.	Hydrogen	77-85	TNF receptor superfamily member 13C	Homo sapiens	172-178
15522303-2	2004	Crystallography and enzymology involving WT and Ala190 uPA were used to calculate free energy binding contributions of hydrogen bonds involving the Ser190 hydroxyl group (O(gamma)(Ser190)) responsible for the remarkable selectivity of 6-halo-5-amidinoindole and 6-halo-5-amidinobenzimidazole inhibitors toward uPA and against natural Ala190 protease anti-targets.	Hydrogen	119-127	plasminogen activator, urokinase	Homo sapiens	55-58
15578836-7	2004	Moreover the X-ray structure of rac-2 was also determined and exhibits as an outstanding feature the formation of a one-dimensional supramolecular species in which the cohesion of the system is maintained by strong hydrogen bonding between carboxylic acid groups of enantiomers Delta-2 and Lambda-2 (cationic parts) with d(O...O) = 2.6 A in agreement with the infrared results.	Hydrogen	215-223	Rac family small GTPase 2	Homo sapiens	32-37
15571862-6	2004	An X-ray analysis of 10a including water and DMF illustrates a possible hydrogen bond pattern and could serve as information for preferred receptor (e.g. EGFR tyrosine kinase) binding sites.	Hydrogen	72-80	epidermal growth factor receptor	Homo sapiens	154-158
15522303-2	2004	Crystallography and enzymology involving WT and Ala190 uPA were used to calculate free energy binding contributions of hydrogen bonds involving the Ser190 hydroxyl group (O(gamma)(Ser190)) responsible for the remarkable selectivity of 6-halo-5-amidinoindole and 6-halo-5-amidinobenzimidazole inhibitors toward uPA and against natural Ala190 protease anti-targets.	Hydrogen	119-127	plasminogen activator, urokinase	Homo sapiens	310-313
15543946-9	2004	We conclude that these hydrogen bond interactions are critical for Jak2 kinase function and subsequent angiotensin II-dependent activation of the Jak/STAT signaling pathway.	Hydrogen	23-31	angiotensinogen	Homo sapiens	103-117
15518541-9	2004	The C-terminal conformational discrepancy between the solution and crystal was caused by the intermolecular hydrogen bond between Tyr 13 of one molecule and Asp 8 of the other in a dimer-like formation of crystalline ET-1.	Hydrogen	108-116	endothelin 1	Homo sapiens	217-221
15516124-5	2004	Initial hydrogen uptake rate measurements determined that, due to the adsorption of ambient background gases, the rate-limiting step for alpha or beta phase PdH formation is dissociative chemisorption of hydrogen for each palladium alloy film.	Hydrogen	8-16	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	157-160
15516124-5	2004	Initial hydrogen uptake rate measurements determined that, due to the adsorption of ambient background gases, the rate-limiting step for alpha or beta phase PdH formation is dissociative chemisorption of hydrogen for each palladium alloy film.	Hydrogen	204-212	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	157-160
15489127-2	2004	The hydrogel, which was formed by physical cross-linking spontaneously without any chemical reactions and/or any physical stimuli, showed a controllable insulin release through a pH change in the medium by changing the hydrogen bonds.	Hydrogen	219-227	insulin	Homo sapiens	153-160
15465057-6	2004	This describes a plausible role for the ring in operating a hydrophobic switch from within the aromatic cluster of helix 6 of rhodopsin, which is coupled to electronic changes within the receptor through water-mediated, hydrogen-bonded networks between the conserved residues in G protein-coupled receptors.	Hydrogen	220-228	rhodopsin	Homo sapiens	126-135
15381432-1	2004	Native state hydrogen exchange experiments have shown that the cytochrome c (Cyt c) protein consists of five cooperative folding-unfolding units, called foldons.	Hydrogen	13-21	cytochrome c, somatic	Homo sapiens	63-75
15381432-1	2004	Native state hydrogen exchange experiments have shown that the cytochrome c (Cyt c) protein consists of five cooperative folding-unfolding units, called foldons.	Hydrogen	13-21	cytochrome c, somatic	Homo sapiens	77-82
15549599-1	2004	The model system of poly(ethylene-oxide) or PEO, where the changing hydrogen-bond connectivity of the water has large effect on the conformation of the polymer chain, in mixtures of water and acetonitrile, is experimentally studied.	Hydrogen	68-76	twinkle mtDNA helicase	Homo sapiens	44-47
15466045-10	2004	Bound glucose forms hydrogen bonds with the residues Asn99, Asp100, Glu157, His160, and Glu187, all of which, except His160, are structurally conserved in human hexokinase 1.	Hydrogen	20-28	hexokinase 1	Homo sapiens	161-173
15453699-3	2004	On the basis of the thermodynamic data and the isotherms measured at 0% RH, 1-hexanol and hexanal had higher binding affinities than hexane, which could be attributed to hydrogen-bonding interactions with SPI.	Hydrogen	170-178	chromogranin A	Homo sapiens	205-208
15553218-6	2004	Likewise, the oxidized derivative (i.e., the pyridine) was identified as the final product of the reaction by GC-MS. By using the technique of deuterium kinetic isotope effect, the participation of the hydrogen of the 1-position on the 1,4-DHP ring was shown not to be the rate-limiting step of the reaction.	Hydrogen	202-210	dihydropyrimidinase	Homo sapiens	240-243
15178581-7	2004	Examination of the FLT3 autoinhibited structure showed that N841 is the key residue in a hydrogen-bonding network that likely stabilizes the activation loop.	Hydrogen	89-97	fms related receptor tyrosine kinase 3	Homo sapiens	19-23
15379554-6	2004	Gankyrin is conformationally more stable than the tumor suppressor p16(INK4A), possibly due to the structural roles of conserved residues evidenced by slowly exchanging backbone amides as well as hydrogen bonding networks involving labile side chain protons.	Hydrogen	196-204	proteasome 26S subunit, non-ATPase 10	Homo sapiens	0-8
15310202-2	2004	Irradiation in the UV region promotes alpha-hydrogen rearrangement of CH(3)TiF to CH(2)=TiHF and increases the yield of (CH(3))(2)TiF(2).	Hydrogen	44-52	TYRO3 protein tyrosine kinase	Homo sapiens	75-78
15368571-3	2004	Glu181 and Ser186 form a network of hydrogen bonds mediated by a water molecule in the dark-state crystal structure of rhodopsin.	Hydrogen	36-44	rhodopsin	Homo sapiens	119-128
15273299-7	2004	The general-base-catalyzed hydroxyl proton abstraction from substrate concerted with hydride transfer to the C5 of PQQ is assisted by hydrogen-bonding to the C5=O by Wat1 and Arg 324 in MDH and by Wat89 and Arg 228 in sGDH.	Hydrogen	134-142	MTOR associated protein, LST8 homolog	Homo sapiens	166-170
15248254-2	2004	In the first series (1-3) the coupling between a hydrogen, bonded to an sp3 carbon, and an sp2 carbon is treated; the second series (4-6) deals with the coupling between a hydrogen, bonded to an sp3 carbon, and an sp3 carbon.	Hydrogen	49-57	Sp3 transcription factor	Homo sapiens	72-75
15248254-2	2004	In the first series (1-3) the coupling between a hydrogen, bonded to an sp3 carbon, and an sp2 carbon is treated; the second series (4-6) deals with the coupling between a hydrogen, bonded to an sp3 carbon, and an sp3 carbon.	Hydrogen	49-57	Sp2 transcription factor	Homo sapiens	91-94
15258400-0	2004	Analysis of the less common hydrogen bonds involving ester oxygen sp3 atoms as acceptors in the crystal structures of small organic molecules.	Hydrogen	28-36	Sp3 transcription factor	Homo sapiens	66-69
15243184-0	2004	1H, 15N, and 13C resonance assignments of calmodulin complexed with the calmodulin-binding domain of calcineurin.	Hydrogen	0-2	calmodulin 1	Homo sapiens	42-52
15243184-0	2004	1H, 15N, and 13C resonance assignments of calmodulin complexed with the calmodulin-binding domain of calcineurin.	Hydrogen	0-2	calmodulin 1	Homo sapiens	72-82
15243188-0	2004	1H, 13C and 15N assignments of the tandem WW domains of human MAGI-1/BAP-1.	Hydrogen	0-2	membrane associated guanylate kinase, WW and PDZ domain containing 1	Homo sapiens	62-68
15243188-0	2004	1H, 13C and 15N assignments of the tandem WW domains of human MAGI-1/BAP-1.	Hydrogen	0-2	BRCA1 associated protein 1	Homo sapiens	69-74
15177440-3	2004	To perceive the exact mode of binding of these ligands, two models of the ligand-EGFR complexes were considered: (1) reversible binding mode in which the ligand had hydrogen bond interactions at the binding site and (2) irreversible binding mode wherein the ligand"s Michael acceptor side chain has proximity to the sulfhydryl group of C773 of EGFR, thereby enabling a covalent interaction.	Hydrogen	165-173	epidermal growth factor receptor	Homo sapiens	81-85
15320967-7	2004	The longer the cells stay in the stationary phase in 1H (insulin) medium, the higher will be the total thyroglobulin production and the initial rate in thyroglobulin production after TSH addition.	Hydrogen	53-55	insulin	Homo sapiens	57-64
15320967-8	2004	The longer the cells stay in the stationary phase in 1H (insulin) medium, the higher are cyclic adenosine monophosphate (cAMP) levels after thyrotropin (TSH) stimulation.	Hydrogen	53-55	insulin	Homo sapiens	57-64
15267238-5	2004	It is proposed that the high potency displayed by these macrocyclic DAG-bis-lactones results from a set of more favorable hydrogen bonding and hydrophobic interactions with PKCalpha as well as from a reduced entropy penalty due to conformational restriction.	Hydrogen	122-130	protein kinase C alpha	Homo sapiens	173-181
15245788-2	2004	To examine this problem, we used human recombinant IL-6 applied intranasally (400 ng/40 microl) to rats 1h before seizures induced by systemic injection of pentylenenetrazole (PTZ, 75 mg/kg).	Hydrogen	104-106	interleukin 6	Homo sapiens	51-55
15250683-1	2004	We present an ab initio direct dynamics trajectory study of the hydrogen abstraction reaction: H2CO+ + CD4 --&gt; H2COD+ + CD3, with methane excited in two different distortion modes (nu4 and nu2).	Hydrogen	64-72	CD4 molecule	Homo sapiens	103-106
15239654-5	2004	Molecular modifications of the ligand NAD moiety, including nonpolar groups and hydrogen bond donor and acceptor groups, seemingly improve ligand interactions with amino acid residues of the InhA active site.	Hydrogen	80-88	inhibin subunit alpha	Homo sapiens	191-195
15210125-5	2004	Measurements of hydrogen/deuterium exchange (HDX) in the isolated SH2 domain and full-length Grb2 protein as monitored by electrospray mass spectrometry, showed that binding reduces the overall flexibility of the proteins, possibly via slightly different mechanisms for the single SH2 domain and the full-length Grb2 protein.	Hydrogen	16-24	growth factor receptor bound protein 2	Homo sapiens	93-97
15224342-3	2004	In apolar solvents this tetraurea calix[4]arene 5 forms regioselectively a single hydrogen-bonded homodimer, from which the bis[2]catenane 10a is formed in 49% by a metathesis reaction followed by hydrogenation.	Hydrogen	82-90	superoxide dismutase 1	Homo sapiens	98-107
15237171-0	2004	rac-3-(5-Amino-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-phenylthiazolidin-4-one: sheets built from N-H...N and C-H...pi(arene) hydrogen bonds.	Hydrogen	123-131	Rac family small GTPase 3	Homo sapiens	0-5
16459590-4	2004	Localization of PPOMA inside the mixed micelles is considered (i) using 1H NMR to localize the methacrylate function at the hydrophobic core-water interface and (ii) by studying the SDS-PPO micellar system (whose M(w) = 400 g x mol(-1)).	Hydrogen	72-74	protoporphyrinogen oxidase	Homo sapiens	16-19
15158089-5	2004	Phosphorylated FLT3 was detected by immunoprecipitation/Western analysis in peripheral blood samples from 17 of 22 patients, and seven exhibited strong inhibition of phosphorylation immediately following a 1h SU5416 infusion, demonstrating that SU5416 can modulate RTK phosphorylation in humans.	Hydrogen	206-208	fms related receptor tyrosine kinase 3	Homo sapiens	15-19
15220221-0	2004	Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies.	Hydrogen	98-100	adenosine A1 receptor	Rattus norvegicus	20-41
15338437-1	2004	We observed by SANS and NMR the structure of intermolecular complexes formed through hydrogen bonding and hydrophobic interactions between a polyacid and a neutral copolymer surfactant (PEO-PPO-PEO).	Hydrogen	85-93	twinkle mtDNA helicase	Homo sapiens	186-189
15338437-1	2004	We observed by SANS and NMR the structure of intermolecular complexes formed through hydrogen bonding and hydrophobic interactions between a polyacid and a neutral copolymer surfactant (PEO-PPO-PEO).	Hydrogen	85-93	twinkle mtDNA helicase	Homo sapiens	194-197
15215520-3	2004	To characterize the folded state of IkappaBalpha (67-317) when it is not in complex with NF-kappaB, we have carried out circular dichroism (CD) spectroscopy, 8-anilino-1-napthalenesulphonic acid (ANS) binding, differential scanning calorimetry, and amide hydrogen/deuterium exchange experiments.	Hydrogen	255-263	NFKB inhibitor alpha	Homo sapiens	36-48
15248964-3	2004	The complexes has CS symmetry, with the HX subunit lying in the plane perpendicular to that of CYC nuclei of heterocyclic and acting as proton donor in forming a hydrogen bond to the heteroatom, Y.	Hydrogen	162-170	cytochrome c, somatic	Homo sapiens	95-98
15350465-6	2004	The frequencies of the two alleles of HA-1 in the recipient population were HA-1R = 0.663 and HA-1H = 0.336.	Hydrogen	97-99	Rho GTPase activating protein 45	Homo sapiens	38-42
15209503-0	2004	Non-native interhelical hydrogen bonds in the cystic fibrosis transmembrane conductance regulator domain modulated by polar mutations.	Hydrogen	24-32	CF transmembrane conductance regulator	Homo sapiens	46-97
15213442-0	2004	1H, 15N and 13C backbone assignment of the carboxyl terminal domain of the cytokine binding module of the interleukin-6 receptor.	Hydrogen	0-2	interleukin 6 receptor	Homo sapiens	106-128
15213460-0	2004	1H, 13C, and 15N resonance assignments of human Notch-1 calcium binding EGF domains 11-13.	Hydrogen	0-2	notch receptor 1	Homo sapiens	48-55
15010500-1	2004	Previously, we demonstrated that malignant glioma cell lines have increased intracellular pH (pHi) as a result of increased activities of the type I sodium/hydrogen exchanger (NHE1).	Hydrogen	156-164	solute carrier family 9 member A1	Homo sapiens	176-180
15212548-3	2004	2D IR correlation spectra of the amide I region of poly-l-lysine, concanavalin A, ribonuclease A, and lysozyme show cross-peaks between the IR-active transitions that are characteristic of amide I couplings for polypeptides in antiparallel hydrogen-bonding registry.	Hydrogen	240-248	lysozyme	Homo sapiens	102-110
15141161-4	2004	The van der Waals contacts by the three residues (Pro157, Leu160, and Leu162) of pepJIP1 and the hydrogen bonding between Glu329 of JNK1 and Arg156 of pepJIP1 are critical for the selective binding.	Hydrogen	97-105	mitogen-activated protein kinase 8	Homo sapiens	132-136
15146520-4	2004	The rapid exchange of free H2 into the tetrahydride proceeds via reversible halide bridge rupture and the formation of [Rh(H)2(PPh3)2(mu-Cl)RhCl(H)2(PPh3)2].	Hydrogen	27-29	caveolin 1	Homo sapiens	127-131
15147208-3	2004	In leghemoglobin, the imidazole side chain of His(E7) is confined to a single conformation, which only weakly hydrogen bonds to bound ligands.	Hydrogen	110-118	leghemoglobin A	Glycine max	3-16
15147208-8	2004	If hydrogen bonding from His(E7) were as strong as it is in mammalian myoglobin, the resultant ultrahigh affinity of leghemoglobin would prevent oxygen transport in root nodules.	Hydrogen	3-11	leghemoglobin A	Glycine max	117-130
15153097-4	2004	The dimerization may be induced by hydrogen bonding of the C-terminal carboxylic groups or by the strictly conserved C-terminal heptapeptide segment with a motif similar to the GxxxG dimerization motif of glycophorin A.	Hydrogen	35-43	glycophorin A (MNS blood group)	Homo sapiens	205-218
15124217-0	2004	Benzyl alcohol-induced destabilization of interferon-gamma: a study by hydrogen-deuterium isotope exchange.	Hydrogen	71-79	interferon gamma	Homo sapiens	42-58
16783936-4	2004	The most internal stable position involved a hydrogen bond between the ring Nepsilon of Trp2 and the backbone carbonyl of Glu90.	Hydrogen	45-53	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	88-92
15146482-8	2004	The model of BmKK2/rSK2 channel complex exhibited favorable contacts both in electrostatic and hydrophobic, including a network of five hydrogen bonds and bigger interface containing seven pairs of inter-residue interactions.	Hydrogen	136-144	potassium calcium-activated channel subfamily N member 2	Rattus norvegicus	19-23
15146520-4	2004	The rapid exchange of free H2 into the tetrahydride proceeds via reversible halide bridge rupture and the formation of [Rh(H)2(PPh3)2(mu-Cl)RhCl(H)2(PPh3)2].	Hydrogen	27-29	caveolin 1	Homo sapiens	149-153
15103622-5	2004	Three differentiated interaction modes between CD4 and gp120 were found, which involve electrostatics, hydrogen bond and van der Waals networks.	Hydrogen	103-111	CD4 molecule	Homo sapiens	47-50
15110837-3	2004	The results indicate that hydrogen bonding plays a key role in the 5-HT1E/receptor interaction.	Hydrogen	26-34	5-hydroxytryptamine receptor 1E	Homo sapiens	67-73
15110861-7	2004	The results indicate that the steric, electrostatic, and hydrogen bond donor/acceptor substituents play significant role in uPA activity and selectivity of these compounds.	Hydrogen	57-65	plasminogen activator, urokinase	Homo sapiens	124-127
15123809-4	2004	We simulate the thermal unfolding of rhodopsin by breaking the native-state hydrogen bonds sequentially in the order of their relative strength, using the recently developed Floppy Inclusion and Rigid Substructure Topography (FIRST) method [Jacobs, D. J., Rader, A. J., Kuhn, L. A.	Hydrogen	76-84	rhodopsin	Homo sapiens	37-46
15111052-5	2004	The SP-Ci helix does not aggregate or unfold during several weeks of incubation, as judged by hydrogen/deuterium exchange and mass spectrometry.	Hydrogen	94-102	surfactant protein C	Homo sapiens	4-9
15111052-6	2004	Hydrogen/deuterium exchange experiments further indicate that the propeptide reduces exchange in parts corresponding to mature SP-C.	Hydrogen	0-8	surfactant protein C	Homo sapiens	127-131
15122890-1	2004	The solvent accessibility of thrombin in its substrate-free and substrate-bound forms has been compared by amide hydrogen/deuterium (H/(2)H) exchange.	Hydrogen	113-121	coagulation factor II, thrombin	Homo sapiens	29-37
18969416-1	2004	In combination with abasic site (AP site)-containing oligodeoxynucleotides (ODNs), we demonstrate potential use of a hydrogen bond forming ligand, 2-amino-7-methyl-1,8-naphthyridine (AMND), for the fluorescence detection of the cytosine (C)/guanine (G) mutation sequence of the cancer repression gene p53.	Hydrogen	117-125	tumor protein p53	Homo sapiens	301-304
15134582-7	2004	The absence of the cystathionine beta synthase enzyme in human vascular cells contributes to the importance of a dual role of folic acid in lowering tHcy through remethylation, as well as, its action of being an electron and hydrogen donor to the essential cofactor tetrahydrobiopterin.	Hydrogen	225-233	cystathionine beta-synthase	Homo sapiens	19-46
15106988-9	2004	A water situated 3.52 A above the proposed site of the lone pair on Pb(II) in 1 is oriented in such a way that it might be thought to be forming a Pb-Lp.H-O-H hydrogen bond.	Hydrogen	159-167	submaxillary gland androgen regulated protein 3B	Homo sapiens	68-74
15033544-10	2004	TNF-alpha and IL-1beta presented a maximum response after 1h treatment, while IL-6 and IL-8 maximum response was after 3h treatment.	Hydrogen	58-60	tumor necrosis factor	Homo sapiens	0-9
15033544-10	2004	TNF-alpha and IL-1beta presented a maximum response after 1h treatment, while IL-6 and IL-8 maximum response was after 3h treatment.	Hydrogen	58-60	interleukin 1 beta	Homo sapiens	14-22
15096633-3	2004	We report the three-dimensional solution structures of the C-terminal headpiece subdomains of human villin (HVcHP) and human advillin (HAcHP), determined by two-dimensional 1H-NMR.	Hydrogen	173-175	advillin	Homo sapiens	125-133
14741607-1	2004	Hydrogen absorption behavior of a beta titanium alloy in acid fluoride solutions has been analyzed by hydrogen thermal desorption.	Hydrogen	0-8	amyloid beta precursor protein	Homo sapiens	32-38
14741607-1	2004	Hydrogen absorption behavior of a beta titanium alloy in acid fluoride solutions has been analyzed by hydrogen thermal desorption.	Hydrogen	102-110	amyloid beta precursor protein	Homo sapiens	32-38
15056609-3	2004	Our phenotypic and biochemical analyses reveal that HS levels are dramatically reduced in the absence of Sotv or its partner co-polymerase Tout velu (Ttv), suggesting that both copolymerases are essential for GAG synthesis.	Hydrogen	52-54	tout-velu	Drosophila melanogaster	139-148
14966128-5	2004	Examination of a series of wild type and mutant Stat3 proteins demonstrated loss of binding to pYXXQ-containing peptides only in Stat3 mutated at Lys-591 or Arg-609, whose side chains interact with the Tyr(P) residue, and Stat3 mutated at Glu-638, whose amide hydrogen bonds with oxygen within the +3 Gln side chain when the peptide ligand assumes a beta-turn.	Hydrogen	260-268	signal transducer and activator of transcription 3	Homo sapiens	48-53
15046516-9	2004	Molecular mechanics-based docking calculations suggest that one leg of Tatren coordinates to the catalytic Zn(2+) in MMPs-2, -9, and -13 with significant hydrogen bonding to backbone amide groups.	Hydrogen	154-162	matrix metallopeptidase 13	Homo sapiens	117-121
15096035-2	2004	We examined the protonation and hydrogen bonding state of the metal-free His residue (His41) in bovine SOD by UV Raman spectroscopy.	Hydrogen	32-40	superoxide dismutase 1	Homo sapiens	103-106
15096035-4	2004	Upon deprotonation of His41 at pH 9.4, the Thr37-His41-His118 hydrogen bond bridge breaks on the His118 side and SOD loses 70% of its activity.	Hydrogen	62-70	superoxide dismutase 1	Homo sapiens	113-116
15065862-4	2004	We have tested this hypothesis with uracil DNA glycosylase (UDG) by constructing a series of DNA duplexes containing a single uracil (U) opposite a variety of bases (X) that formed from zero to three hydrogen bonds with U.	Hydrogen	200-208	uracil DNA glycosylase	Homo sapiens	60-63
14769057-3	2004	The conformational rigidity imparted to the fold by the presence of hydrogen-bonded, C5, C7, C10 and C13 structures in the loop regions, multiple aromatic--aromatic interactions at the protein interior and on the surface, in addition to salt-links and hydrogen-bonds are primarily the major factors, responsible for the increased stability of protein.	Hydrogen	252-260	homeobox C10	Homo sapiens	93-96
15039302-7	2004	Therefore, a hydrophobic moiety at the 5-position and a hydrogen-bond acceptor being sufficiently separated from the phenyl-ring are responsible for activation of hPXR by barbiturates.	Hydrogen	56-64	nuclear receptor subfamily 1 group I member 2	Homo sapiens	163-167
15039302-13	2004	These findings suggest that hydrophobicity of the ligand and adequate distance between the hydrogen-bond acceptor and the hydrophobic group are important for hPXR activation.	Hydrogen	91-99	nuclear receptor subfamily 1 group I member 2	Homo sapiens	158-162
14872132-0	2004	1H, 13C, and 15N resonance assignments of the hepatocyte nuclear factor 6 alpha (HNF-6 alpha).	Hydrogen	0-2	one cut homeobox 1	Homo sapiens	46-79
14872132-0	2004	1H, 13C, and 15N resonance assignments of the hepatocyte nuclear factor 6 alpha (HNF-6 alpha).	Hydrogen	0-2	one cut homeobox 1	Homo sapiens	81-92
14872135-0	2004	Assignment of 1H, 13C and 15N resonances of the death domain of TRADD.	Hydrogen	14-16	TNFRSF1A associated via death domain	Homo sapiens	64-69
14872138-0	2004	1H, 15N, and 13C resonance assignments of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, Mr. 32,000)--a protein inhibitor of protein phosphatase-1.	Hydrogen	0-2	protein phosphatase 1 regulatory inhibitor subunit 1B	Homo sapiens	42-50
14872321-0	2004	Hydrogen bonding interactions in E- or Z-2-phenyl-3-( X"-pyridyl)propenoic acid ( X=2, 3 or 4) assemblies--a molecular modeling study.	Hydrogen	0-8	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	82-93
15099445-3	2004	The structure-activity relationship (SAR) study with 12 compounds on tumour necrosis factor (TNF)-alpha inhibition, analysed by the oxime geometry and different size of spacers between the oxime and phenyl group, indicated that there might be at least three possible hydrogen bonding sites in the inhibitor binding pocket of PDE IV.	Hydrogen	267-275	tumor necrosis factor	Mus musculus	69-103
14718582-10	2004	In conclusion, DHPs indirectly alter NTR1 function in live cells by a mechanism that depends on the drug"s ability to donate hydrogen but does not simply involve sulfhydryl reduction.	Hydrogen	125-133	deoxyhypusine synthase	Homo sapiens	15-19
15801461-5	2004	Electrostatic attachment of the protein involved ion-pair and hydrogen-bond interactions between the terminating carboxylic acid groups of the DDCA-functionalized ITO and the primary amine groups of the lysine residues of cytochrome c.	Hydrogen	62-70	cytochrome c, somatic	Homo sapiens	222-234
14985092-1	2004	We report here the interaction of bradykinin with ganglioside GM1 by circular dichroism, steady-state fluorescence, and one-dimensional 1H NMR spectroscopy.	Hydrogen	136-138	kininogen 1	Homo sapiens	34-44
15252489-13	2004	The presence of all possible Delta- and Lambda-[Co(II)(5)x(bipy)(3-x)]2+ complexes was inferred from 1H NMR and ES-MS spectra.	Hydrogen	101-103	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
14990996-6	2004	The structure of the SBD-chitobiose complex includes hydrogen bonds between Fbs1 and chitobiose and insertion of the methyl group of chitobiose into a small hydrophobic pocket of Fbs1.	Hydrogen	53-61	F-box protein 2	Homo sapiens	76-80
15006409-0	2004	1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative.	Hydrogen	0-2	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-55
15026545-2	2004	Structure-activity studies in PPARgamma-dependent transactivation assays in MCF-7 breast cancer cells show that 5-20 micro M concentrations of compounds containing p-trifluoromethyl, t-butyl, cyano, dimethylamino, and phenyl groups were active, whereas p-methyl, hydrogen, methoxy, hydroxyl, or halogen groups were inactive as PPARgamma agonists.	Hydrogen	263-271	peroxisome proliferator activated receptor gamma	Homo sapiens	30-39
14752266-0	2004	1H, 13C and 15N resonance assignments of the region 1463-1617 of the mouse p53 binding protein 1 (53BP1).	Hydrogen	0-2	transformation related protein 53 binding protein 1	Mus musculus	75-96
14752266-0	2004	1H, 13C and 15N resonance assignments of the region 1463-1617 of the mouse p53 binding protein 1 (53BP1).	Hydrogen	0-2	transformation related protein 53 binding protein 1	Mus musculus	98-103
14735577-0	2004	A computational study of the role of hydrogen bonds in SN1 and E1 reactions.	Hydrogen	37-45	solute carrier family 38 member 3	Homo sapiens	55-58
14660584-4	2004	1H/2H exchange monitored by attenuated total reflection Fourier transform IR spectroscopy demonstrates that CFTR is highly accessible to aqueous medium.	Hydrogen	0-2	CF transmembrane conductance regulator	Homo sapiens	108-112
14660584-7	2004	Moreover, the combination of polarized IR spectroscopy with 1H/2H exchange suggested an increase of the accessibility of the transmembrane domains of CFTR.	Hydrogen	60-62	CF transmembrane conductance regulator	Homo sapiens	150-154
14755578-3	2004	The crystal structure of HST (1A8E.pdb) was first subjected to a heuristic analysis, in which positively charged and hydrogen-bonding residues on or near the surface of the protein were identified.	Hydrogen	117-125	fibroblast growth factor 4	Homo sapiens	25-28
14742671-8	2004	A large hydrophobic region close to the nucleophile and a hydrogen bond acceptor 10 A from the nucleophile were found to be common to most UGT2B4 substrates.	Hydrogen	58-66	UDP glucuronosyltransferase family 2 member B4	Homo sapiens	139-145
14741295-3	2004	An X-ray crystal structure of a representative member of this series bound to the active site of ICE, confirms the presence of the hydrogen bonding interaction.	Hydrogen	131-139	caspase 1	Homo sapiens	97-100
14733570-3	2004	We measured differential 1H-15N multiple-quantum relaxation rates for the backbone amide groups of the E140Q mutant of the C-terminal domain of calmodulin at three static magnetic field strengths.	Hydrogen	25-27	calmodulin 1	Homo sapiens	144-154
14731277-4	2004	TraR is thought to bind OOHL via four hydrogen bonds, three of them direct and one water mediated, and by numerous hydrophobic interactions.	Hydrogen	38-46	transcriptional regulator TraR	Agrobacterium tumefaciens	0-4
15356719-4	2004	The structure of L(5) shows 3 methanol solvent molecules all of which form 2 or 3 hydrogen bonds with triazine nitrogen atoms, amide nitrogen or oxygen atoms, or pyridine nitrogen atoms.	Hydrogen	82-90	ribosomal protein L5	Homo sapiens	17-21
14628295-0	2004	Absolute configuration of the thyroid hormone analog KAT-2003 as determined by the 1H NMR anisotropy method with a novel chiral auxiliary, MalphaNP acid.	Hydrogen	83-85	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	53-56
14706517-11	2004	A transient up-regulation of p53 occurred 1h post-IR in BGC823 cells but not in MGC803 cells.	Hydrogen	42-44	tumor protein p53	Homo sapiens	29-32
14965309-6	2004	Conformational analysis of the zinc-free and zinc-bound peptides through high resolution 1H NMR Spectroscopy provides new insights into the solution structure of ACE catalytic centers.	Hydrogen	89-91	angiotensin I converting enzyme	Homo sapiens	162-165
15340910-9	2004	By cloning a formate dehydrogenase and an oxidoreductase "designer bug" can be obtained where formate is used instead of glucose as the hydrogen source.	Hydrogen	23-31	oxidoreductase	Saccharomyces cerevisiae S288C	42-56
14658895-3	2003	Complex 1 reacts with dihydrogen to form the known ruthenium hydride complex [Ru(H)2(H2)(PPh3)3] upon hydrogenolysis of the Ru-F bond.	Hydrogen	22-32	caveolin 1	Homo sapiens	89-93
14613973-5	2004	The crystal structure, of Pro252Arg FGFR1c in complex with FGF2, demonstrates that the enhanced ligand binding is due to an additional set of receptor-ligand hydrogen bonds, similar to those gain-of-function interactions that occur in the Apert syndrome Pro253Arg FGFR2c-FGF2 crystal structure.	Hydrogen	158-166	fibroblast growth factor 2	Homo sapiens	59-63
14646130-1	2004	The growth of a large single crystal of cubic porcine insulin for characterization of hydrogen and hydration in cubic insulin crystals by neutron diffraction analysis is reported.	Hydrogen	86-94	insulin	Homo sapiens	54-61
14705028-3	2004	In simulations in chloroform, the Hao-containing peptide 9 (i-PrCO-Phe-Hao-Val-NHBu) forms a beta-sheet-like hydrogen-bonded dimer, in good agreement with the available experimental data.	Hydrogen	109-117	amyloid beta precursor protein	Homo sapiens	91-97
14651962-6	2003	Adiponectin secretion significantly increased 1h following insulin or ET-1 treatment, respectively.	Hydrogen	46-48	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
14651962-6	2003	Adiponectin secretion significantly increased 1h following insulin or ET-1 treatment, respectively.	Hydrogen	46-48	insulin	Homo sapiens	59-66
14651962-6	2003	Adiponectin secretion significantly increased 1h following insulin or ET-1 treatment, respectively.	Hydrogen	46-48	endothelin 1	Homo sapiens	70-74
14667216-4	2003	The results indicated that phenethylamine derivatives nicely fit into the active pocket of ALR2 by forming various hydrogen bonding and hydrophobic interactions.	Hydrogen	115-123	aldo-keto reductase family 1 member B	Homo sapiens	91-95
14690444-0	2003	1H NMR structural characterization of the cytochrome c modifications in a micellar environment.	Hydrogen	0-2	cytochrome c, somatic	Homo sapiens	42-54
14645089-1	2003	The solution structure of NKA, a decapeptide of mammalian origin, has been characterized by CD spectropolarimetry and 2D proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy in both aqueous and membrane mimetic solvents.	Hydrogen	159-161	tachykinin precursor 1	Homo sapiens	26-29
14656079-9	2003	Analysis of hydrogen-bonding patterns shows that each major conformer exhibits a beta-turn like structure and is stabilized by hydrogen bonding between a different carbonyl group of the pyruvyl unit of the molecule"s side chain and the NH of the Thr(6) residue.	Hydrogen	12-20	amyloid beta precursor protein	Homo sapiens	79-85
14656079-9	2003	Analysis of hydrogen-bonding patterns shows that each major conformer exhibits a beta-turn like structure and is stabilized by hydrogen bonding between a different carbonyl group of the pyruvyl unit of the molecule"s side chain and the NH of the Thr(6) residue.	Hydrogen	127-135	amyloid beta precursor protein	Homo sapiens	79-85
14636070-4	2003	From hydrogen-deuterium exchange, the secondary structure of the water-accessible part of 5-HT(3)R was determined as 14% alpha-helix, 16% beta-strand, 26% beta-turn, and 14% nonregular structures.	Hydrogen	5-13	5-hydroxytryptamine receptor 3A	Homo sapiens	90-98
14640662-2	2003	The formation of the new C-C bond is shown to take place via oxidative coupling of coordinated CO(2) and C(2)H(4) ligands resulting in a metalla-lactone intermediate, which can rearrange to an agostic species allowing for a beta-hydrogen shift process.	Hydrogen	229-237	amyloid beta precursor protein	Homo sapiens	222-228
14515368-1	2003	Hydrogen-bonded interactions between local defect structures on broken clay surfaces modeled as molecular clusters and the organic molecules acetic acid, acetate, and N-methylacetamide (NMA) have been investigated.	Hydrogen	0-8	BMP and activin membrane bound inhibitor	Homo sapiens	167-190
15124931-14	2003	With the present modelling study we conclude that the principal properties to be possessed by the new leads against p50-DNA binding should be that of having the ability to make a strong network of hydrogen bonds with the DBR of p50, and preferably, having electronegative potentials in their peripheral surface.	Hydrogen	197-205	nuclear factor kappa B subunit 1	Homo sapiens	116-119
15124931-14	2003	With the present modelling study we conclude that the principal properties to be possessed by the new leads against p50-DNA binding should be that of having the ability to make a strong network of hydrogen bonds with the DBR of p50, and preferably, having electronegative potentials in their peripheral surface.	Hydrogen	197-205	nuclear factor kappa B subunit 1	Homo sapiens	228-231
14634667-2	2003	Two sodium-hydrogen exchangers (NHE1 and NHE5) are expressed in spermatozoa.	Hydrogen	11-19	solute carrier family 9 member A1	Homo sapiens	32-36
14623190-1	2003	A cytochrome c kinetic folding intermediate was studied by hydrogen exchange (HX) pulse labeling.	Hydrogen	59-67	cytochrome c, somatic	Homo sapiens	2-14
14596622-3	2003	A complete reorientation of the Met43 side chain toward the hydrophobic core is accomplished by the disappearance of the millisecond dynamics observed on the native form of Calbindin D(9k), while cross correlation rates provide evidence that the two-way hydrogen bond between Leu23 and Val61 is broken or substantially weakened.	Hydrogen	254-262	S100 calcium binding protein G	Homo sapiens	173-187
14639640-5	2003	The crystal structure of rac-2 reveals meso bilayers of hydrogen-bonded aggregates.	Hydrogen	56-64	Rac family small GTPase 2	Homo sapiens	25-30
14613317-3	2003	Modeling studies reported here suggest that in the inactive state of CB(1), the binding site of the CB(1) inverse agonist/antagonist SR141716A is within the TMH3-4-5-6 aromatic microdomain and involves direct aromatic stacking interactions with F3.36, Y5.39, and W5.43, as well as hydrogen bonding with K3.28.	Hydrogen	281-289	cannabinoid receptor 1	Homo sapiens	69-74
14613317-3	2003	Modeling studies reported here suggest that in the inactive state of CB(1), the binding site of the CB(1) inverse agonist/antagonist SR141716A is within the TMH3-4-5-6 aromatic microdomain and involves direct aromatic stacking interactions with F3.36, Y5.39, and W5.43, as well as hydrogen bonding with K3.28.	Hydrogen	281-289	cannabinoid receptor 1	Homo sapiens	100-105
14557006-5	2003	RESULTS: Overall pre-prandial blood glucose values in diabetic women were significantly higher than those of controls; at the 1h post-prandial time point, blood glucose values of GDM women receiving insulin lispro were similar to those of controls, whereas in the regular group they were significantly higher.	Hydrogen	126-128	insulin	Homo sapiens	199-206
14559970-7	2003	We find that the activation energy for the rupture of the hydrogen bond in a beta-sheet under isolated conditions is 4.76 kcal/mol, and the activation energy is 1.58 kcal/mol for the same beta-sheet in water.	Hydrogen	58-66	amyloid beta precursor protein	Homo sapiens	75-81
14557006-9	2003	In women with GDM, the use of insulin lispro enabled the attainment of near-normal glucose levels at the 1h post-prandial time point and was associated with normal anthropometric characteristics; the use of regular insulin was not able to blunt the 1h peak post-prandial response to a near-normal extent and resulted in infants with a tendency toward the disproportionate growth.	Hydrogen	105-107	insulin	Homo sapiens	30-37
14641597-4	2003	H2 removal by Shewanella oneidensis was detected at cell concentrations of 1.0 x 10(6) live cells ml-1 and higher and H2 was electron donor for denitrification of NO3-.	Hydrogen	0-2	NBL1, DAN family BMP antagonist	Homo sapiens	163-166
14641597-4	2003	H2 removal by Shewanella oneidensis was detected at cell concentrations of 1.0 x 10(6) live cells ml-1 and higher and H2 was electron donor for denitrification of NO3-.	Hydrogen	118-120	NBL1, DAN family BMP antagonist	Homo sapiens	163-166
14551349-14	2003	CONCLUSIONS: These findings suggest that alterations in HS-GAG chemistry or metabolism under pathological conditions, such as DN, may have direct functional consequences for the local effect of Ang II.	Hydrogen	56-58	angiotensinogen	Homo sapiens	194-200
14568937-5	2003	Moreover, we show that H2-D blockage inhibits the ability of immature B cells to transcribe the IFN-gamma gene and results in rescue of cytoskeletal rearrangement.	Hydrogen	23-25	interferon gamma	Homo sapiens	96-105
14661924-10	2003	CONCLUSIONS: Nonpolar bulky substituents around the C-6alpha position, as well as a hydrogen-bond donor at position C-11, enhance P-glycoprotein affinity and cellular efflux, whereas bulky substituents at C-16 diminish transporter affinity.	Hydrogen	84-92	ATP binding cassette subfamily B member 1	Homo sapiens	130-144
14561085-9	2003	They are more likely to have multiple binding modes at the ATP site of EGFR, i.e., either modes A or B, than in the ATP site of HER-2 where they are possibly limited to only binding mode, A. Selectivity of the methoxy compounds on the other hand appears to depend on hydrogen bonding interactions involving the cyano group and residue 751 in the ATP site.	Hydrogen	267-275	epidermal growth factor receptor	Homo sapiens	71-75
14561085-9	2003	They are more likely to have multiple binding modes at the ATP site of EGFR, i.e., either modes A or B, than in the ATP site of HER-2 where they are possibly limited to only binding mode, A. Selectivity of the methoxy compounds on the other hand appears to depend on hydrogen bonding interactions involving the cyano group and residue 751 in the ATP site.	Hydrogen	267-275	erb-b2 receptor tyrosine kinase 2	Homo sapiens	128-133
14561087-6	2003	Pharmacophores with good hydrogen bonding potential, such as morpholine, pyridine, and imidazole, shift the melting temperature of p38alpha by 16-17 degrees C translating into K(d) values of 50-100 pM.	Hydrogen	25-33	mitogen-activated protein kinase 14	Homo sapiens	131-139
14510824-3	2003	Previous evidence in a Japanese population shows that the homozygotes for allele 2 at position -511 of the interleukin (IL)-1 beta gene promoter region (IL-1 beta-511*2/2) confers susceptibility to the development of HS.	Hydrogen	217-219	interleukin 1 beta	Homo sapiens	107-130
14529297-0	2003	Probing hydrogen-bonding interactions in the active site of medium-chain acyl-CoA dehydrogenase using Raman spectroscopy.	Hydrogen	8-16	acyl-CoA dehydrogenase medium chain	Sus scrofa	60-95
14501117-8	2003	A number of additional hydrogen bonds between the two domains in the N and C lobes have been identified in the structure of hST compared with that of hOT, which indicate a greater compactness of the lobes of hST than those of hOT.	Hydrogen	23-31	fibroblast growth factor 4	Homo sapiens	124-127
14501117-8	2003	A number of additional hydrogen bonds between the two domains in the N and C lobes have been identified in the structure of hST compared with that of hOT, which indicate a greater compactness of the lobes of hST than those of hOT.	Hydrogen	23-31	fibroblast growth factor 4	Homo sapiens	208-211
14510824-3	2003	Previous evidence in a Japanese population shows that the homozygotes for allele 2 at position -511 of the interleukin (IL)-1 beta gene promoter region (IL-1 beta-511*2/2) confers susceptibility to the development of HS.	Hydrogen	217-219	interleukin 1 beta	Homo sapiens	153-162
12974626-0	2003	Hydrogen exchange in a bacterial cytochrome c: a fingerprint of the cytochrome c fold.	Hydrogen	0-8	cytochrome c, somatic	Homo sapiens	33-45
13129380-2	2003	Reactions of laser-ablated copper, silver, and gold with H(2) in excess argon, neon, and pure hydrogen during condensation at 3.5 K give the MH molecules and the (H(2))MH complexes as major products and the MH(2)(-) and AuH(4)(-) anions as minor products.	Hydrogen	57-61	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	220-223
12900436-8	2003	Renal microvascular CYP2C11 and CYP2C23 mRNA levels were reduced in the ANG/HS-HS group compared with both the NS and HS groups.	Hydrogen	76-78	angiotensinogen	Rattus norvegicus	72-75
12900436-8	2003	Renal microvascular CYP2C11 and CYP2C23 mRNA levels were reduced in the ANG/HS-HS group compared with both the NS and HS groups.	Hydrogen	79-81	angiotensinogen	Rattus norvegicus	72-75
13129380-2	2003	Reactions of laser-ablated copper, silver, and gold with H(2) in excess argon, neon, and pure hydrogen during condensation at 3.5 K give the MH molecules and the (H(2))MH complexes as major products and the MH(2)(-) and AuH(4)(-) anions as minor products.	Hydrogen	94-102	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	220-223
12974626-0	2003	Hydrogen exchange in a bacterial cytochrome c: a fingerprint of the cytochrome c fold.	Hydrogen	0-8	cytochrome c, somatic	Homo sapiens	68-80
12974626-1	2003	The hydrogen exchange rates of backbone amides in a minimal (71 amino acid long) monoheme cytochrome c were determined as a function of pH in the absence and in the presence of guanidinium chloride.	Hydrogen	4-12	cytochrome c, somatic	Homo sapiens	90-102
12922170-0	2003	Solution 1H NMR study of the active site molecular structure and magnetic properties of the cyanomet complex of the isolated alpha-chain from human hemoglobin A.	Hydrogen	9-11	Fc gamma receptor and transporter	Homo sapiens	125-136
12972558-6	2003	Indeed purified peptic fragments containing H2, inhibited stress fibers when mixed with FNIII7-10 or fibronectin.	Hydrogen	44-46	fibronectin 1	Homo sapiens	101-112
12968905-5	2003	The binding energy corrected by basis set superposition error with the MP2/cc-pVTZ method based on the MP2/6-31G geometry is -4.37 kcal/mol, which is as strong as the conventional hydrogen bonding.	Hydrogen	180-188	major intrinsic protein of lens fiber	Homo sapiens	103-108
16220923-4	2003	Comparisons with monometallic rhodium catalysts based on PPh3, Bisbi, Naphos, and Xantphos ligands demonstrate that this polar-phase bimetallic catalyst is one of the fastest and most selective hydroformylation systems known under these mild conditions (90 degrees C, 6.2 bar H2/CO).	Hydrogen	276-278	caveolin 1	Homo sapiens	57-61
12924948-4	2003	We have previously demonstrated that hydrogen-bonding residues predicted to be in the inner-leaflet spanning segment of transmembrane (TM) 17 of MRP1 are important for drug resistance and E(2)17 beta G transport.	Hydrogen	37-45	ATP binding cassette subfamily C member 1	Homo sapiens	145-149
12914435-4	2003	Examination utilizing SEM and TEM observations, UV-vis and ATR IR spectral analyses, and XRD analysis revealed that an amide-amide hydrogen-bonding interaction creates a cavity, the size of which is complementary to that of [60]fullerene, and these cavities are connected by another amide-amide hydrogen-bonding interaction to provide a one-dimensional multicapsular structure.	Hydrogen	131-139	ATR serine/threonine kinase	Homo sapiens	59-62
12914435-4	2003	Examination utilizing SEM and TEM observations, UV-vis and ATR IR spectral analyses, and XRD analysis revealed that an amide-amide hydrogen-bonding interaction creates a cavity, the size of which is complementary to that of [60]fullerene, and these cavities are connected by another amide-amide hydrogen-bonding interaction to provide a one-dimensional multicapsular structure.	Hydrogen	295-303	ATR serine/threonine kinase	Homo sapiens	59-62
12899638-0	2003	Hydrogen exchange-mass spectrometry analysis of beta-amyloid peptide structure.	Hydrogen	0-8	amyloid beta precursor protein	Homo sapiens	48-68
12899638-3	2003	In the present study, we use hydrogen-deuterium isotope exchange (HX)-electrospray ionization mass spectrometry (MS) along with enzymatic digestion as a tool to examine at near residue level, the changes in A beta structure associated with aggregation to a fibril form.	Hydrogen	29-37	amyloid beta precursor protein	Homo sapiens	207-213
12815268-0	2003	1H, 15N and 13C resonance assignments of the tetratricopeptide repeat (TPR) domain of hSGT.	Hydrogen	0-2	small glutamine rich tetratricopeptide repeat co-chaperone alpha	Homo sapiens	86-90
12919102-1	2003	HIP is a heparin/heparan sulfate (Hp/HS) binding protein identical to ribosomal protein L29 that displays diverse biological functions.	Hydrogen	37-39	predicted gene 13841	Mus musculus	70-91
12868042-9	2003	The elevated level of erythropoietin 24 h after blood withdrawal was accompanied by a significant increase (p &lt; 0.015) in blood hydrogen ion concentration [H +] b at rest from 48.2 +/- 2.8 nmol x l(-1) in the control study to 52.9 +/- 4.5 nmol x l(-1) after blood donation.	Hydrogen	131-139	erythropoietin	Homo sapiens	22-36
12888278-8	2003	Fluorescence titrations of apotransferrin and both forms of monoferric transferrin with aluminum indicated that there is O cdots, three dots, centered H-O type intramolecular hydrogen bonds for the phenolic groups of Tyr426 and Tyr517 in the C-terminal binding site.	Hydrogen	175-183	transferrin	Homo sapiens	30-41
12672474-4	2003	Thirty-three to forty-two percent more HS bound to the FGF-2 affinity gel in the presence of PF4 than with HS alone.	Hydrogen	39-41	fibroblast growth factor 2	Homo sapiens	55-60
12672474-4	2003	Thirty-three to forty-two percent more HS bound to the FGF-2 affinity gel in the presence of PF4 than with HS alone.	Hydrogen	107-109	fibroblast growth factor 2	Homo sapiens	55-60
12854955-2	2003	In this contribution I report on two illustrative examples, p21ras and p57, revealing that such mutations have an effect on specific structural deficiencies in the packing of the protein structure, i. e., on backbone hydrogen bonds insufficiently shielded from water attack.	Hydrogen	217-225	cyclin dependent kinase inhibitor 1C	Homo sapiens	71-74
12875833-1	2003	Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions.	Hydrogen	0-8	cytochrome c, somatic	Homo sapiens	88-100
12860137-2	2003	The 15N-1H HSQC NMR spectrum of the human alpha-lactalbumin (alpha-LA) molten globule at pH 2 and 20 degrees C is characterised by broad lines which make direct study by NMR methods difficult; this broadening arises from conformational fluctuations throughout the protein on a millisecond to microsecond timescale.	Hydrogen	8-10	lactalbumin alpha	Homo sapiens	42-59
12860137-2	2003	The 15N-1H HSQC NMR spectrum of the human alpha-lactalbumin (alpha-LA) molten globule at pH 2 and 20 degrees C is characterised by broad lines which make direct study by NMR methods difficult; this broadening arises from conformational fluctuations throughout the protein on a millisecond to microsecond timescale.	Hydrogen	8-10	lactalbumin alpha	Homo sapiens	61-69
12860137-3	2003	Here, we find that an increase in temperature to 50 degrees C leads to a dramatic sharpening of peaks in the 15N-1H HSQC spectrum of human alpha-LA at pH 2.	Hydrogen	113-115	lactalbumin alpha	Homo sapiens	139-147
12846569-0	2003	Active peptidic mimics of the second intracellular loop of the V(1A) vasopressin receptor are structurally related to the second intracellular rhodopsin loop: a combined 1H NMR and biochemical study.	Hydrogen	170-172	rhodopsin	Homo sapiens	143-152
12821144-3	2003	After 1h of hydrolysis by chymotrypsin, 80% of CK-MM is intact as judged by quantification of monomers after electrophoresis in sodium dodecyl sulfate.	Hydrogen	6-8	creatine kinase, M-type	Homo sapiens	47-52
12821144-6	2003	When treated with trypsin for 1h, CK-MM is totally resistant to hydrolysis and all CK-BB is highly degraded.	Hydrogen	30-32	creatine kinase, M-type	Homo sapiens	34-39
12821144-6	2003	When treated with trypsin for 1h, CK-MM is totally resistant to hydrolysis and all CK-BB is highly degraded.	Hydrogen	30-32	creatine kinase B	Homo sapiens	83-88
12822982-1	2003	In this communication, we demonstrate the feasibility of 1H detection in MAS solid-state NMR for a microcrystalline, uniformly 2H,15N-labeled sample of a SH3 domain of chicken alpha-spectrin, using pulsed field gradients for suppression of water magnetization.	Hydrogen	57-59	spectrin alpha, non-erythrocytic 1	Gallus gallus	176-190
12927115-4	2003	T, E(LUMO) (the energy of the lowest unoccupied molecular orbital), molecular size or average molecular polarizability (alpha), and the net atomic charges on chlorine, hydrogen and carbon atoms of PCB molecules, are major factors governing logK(OA).	Hydrogen	168-176	pyruvate carboxylase	Homo sapiens	197-200
12855334-3	2003	The present double-blinded, placebo-controlled study was designed to test quantitatively the effect and duration (1h, 1, 7, 14, 21 and 28 days) of NGF (5 microg in 0.2 ml) injected into the masseter muscle.	Hydrogen	114-116	nerve growth factor	Homo sapiens	147-150
12783540-3	2003	The temperature dependence of the EIE for oxidative addition of CH4 and CD4 differs significantly from that for coordination, with the EIE being normal at all temperatures and approaching infinity at 0 K. In contrast to oxidative addition of methane which is normal at all temperatures, the EIE for oxidative addition of H2 and D2 exhibits a transition from inverse to normal upon raising the temperature.	Hydrogen	321-323	CD4 molecule	Homo sapiens	72-75
12747776-8	2003	Hence, physicochemical determinants of binding, such as steric and electrostatic and, for the first time, hydrophobic, hydrogen bond donor, and hydrogen bond acceptor properties, were mapped back onto the molecular structures of a set of nAChR modulators.	Hydrogen	119-127	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	238-243
12763041-3	2003	LPA activated tTGase with a maximal increase at 1h, which was inhibited by cystamine and ROS scavengers.	Hydrogen	48-50	transglutaminase 2	Homo sapiens	14-20
12866877-5	2003	The optimal gas flows established for the detection of sulfur and phosphorus are in the range of 4 mL min(-1) of oxygen and 9 to 13 mL min(-1) of hydrogen.	Hydrogen	146-154	CD59 molecule (CD59 blood group)	Homo sapiens	135-141
12767125-0	2003	Zinc binding in peptide models of angiotensin-I converting enzyme active sites studied through 1H-NMR and chemical shift perturbation mapping.	Hydrogen	95-97	angiotensin I converting enzyme	Homo sapiens	34-65
12697186-6	2003	The adsorption enthalpy change indicated the uptake of phenols on MCH-111 to be an enhanced physical adsorption because of the hydrogen-bonding interaction.	Hydrogen	127-135	pro-melanin concentrating hormone	Homo sapiens	66-69
12742021-2	2003	The active site hydrogen-bonding mode was found to vary markedly with pH, with the steric and electronic properties of the inhibitor, and with the type of protease (trypsin, thrombin or urokinase type plasminogen activator (uPA)).	Hydrogen	16-24	coagulation factor II, thrombin	Homo sapiens	174-182
12742021-2	2003	The active site hydrogen-bonding mode was found to vary markedly with pH, with the steric and electronic properties of the inhibitor, and with the type of protease (trypsin, thrombin or urokinase type plasminogen activator (uPA)).	Hydrogen	16-24	plasminogen activator, urokinase	Homo sapiens	186-229
12742021-7	2003	K(i) values involving uPA and trypsin determined as a function of pH for a set of inhibitors show pronounced parabolic pH dependence, the pH for optimal inhibition governed by the pK(a) of the inhibitor phenol involved in short hydrogen bonds.	Hydrogen	228-236	plasminogen activator, urokinase	Homo sapiens	22-25
12719580-7	2003	The arrangement of these residues, including aromatic side chains and side chains that hydrogen bond across the base of the loop, may rigidify H3 for penetration of the recessed CD4-binding cavity.	Hydrogen	87-95	CD4 molecule	Homo sapiens	178-181
12926375-7	2003	Comparisons with acidity constants taken from the literature show that this latter pKa value is far too large and this allows the conclusion that an intramolecular hydrogen bond is formed between the (N-1/N-3)H site and the phosphonate group of Bimp2-; the formation degree of this hydrogen-bonded isomer is estimated to be 98 +/- 2%.	Hydrogen	164-172	caspase recruitment domain family member 14	Homo sapiens	245-250
12926375-7	2003	Comparisons with acidity constants taken from the literature show that this latter pKa value is far too large and this allows the conclusion that an intramolecular hydrogen bond is formed between the (N-1/N-3)H site and the phosphonate group of Bimp2-; the formation degree of this hydrogen-bonded isomer is estimated to be 98 +/- 2%.	Hydrogen	282-290	caspase recruitment domain family member 14	Homo sapiens	245-250
12604595-4	2003	In the present study, we present an analysis of the changes in hydrogen/deuterium exchange protection and internal motions of the backbone of the D/D when free and bound to the prototype anchoring protein, Ht31(pep).	Hydrogen	63-71	A-kinase anchoring protein 13	Homo sapiens	206-210
12752436-2	2003	Conformational analysis of angiotensin I (AI) and II (AII) peptides has been performed through 2D 1H-NMR spectroscopy in dimethylsulfoxide and 2,2,2-trifluoroethanol/H2O.	Hydrogen	98-100	angiotensinogen	Homo sapiens	27-52
12752436-2	2003	Conformational analysis of angiotensin I (AI) and II (AII) peptides has been performed through 2D 1H-NMR spectroscopy in dimethylsulfoxide and 2,2,2-trifluoroethanol/H2O.	Hydrogen	98-100	NLR family pyrin domain containing 3	Homo sapiens	54-57
12695525-7	2003	Two residues that had not been revealed in our previous mutagenesis studies, Tyr189 (Y4.60) and Asn358 (N6.55), were identified in interaction via hydrogen bonds with the C-terminal amide of CCK, a crucial functional group of the peptide.	Hydrogen	147-155	cholecystokinin	Homo sapiens	191-194
12725863-2	2003	UDG, which operates by a nucleotide flipping mechanism, was first converted into a sequence nonspecific cytosine DNA glycosylase (CDG) by altering the base-specific hydrogen bond donor-acceptor groups in the active site.	Hydrogen	165-173	uracil DNA glycosylase	Homo sapiens	0-3
12660997-1	2003	The ionization properties of the active site residues in Drosophila lebanonensis alcohol dehydrogenase (DADH) were investigated theoretically by using an approach developed to account for multiple locations of the hydrogen atoms of the titratable and polar groups.	Hydrogen	91-99	Alcohol dehydrogenase	Drosophila melanogaster	104-108
12660997-2	2003	The electrostatic calculations show that (a) the protonation/deprotonation transition of the binary complex of DADH is related to the coupled ionization of Tyr151 and Lys155 in the active site and (b) the pH dependence of the proton abstraction is correlated with a reorganization of the hydrogen bond network in the active site.	Hydrogen	288-296	Alcohol dehydrogenase	Drosophila melanogaster	111-115
12682111-7	2003	Coexpression of a Ly49A transgene partially rescued NKT cell development in Ly49D/H2-Dd transgenics, presumably due to attenuation of ITAM signaling.	Hydrogen	82-84	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	18-23
12662361-0	2003	Structures of neuropeptide gamma from goldfish and mammalian neuropeptide gamma, as determined by 1H NMR spectroscopy.	Hydrogen	98-100	tachykinin precursor 1	Homo sapiens	14-32
12662361-0	2003	Structures of neuropeptide gamma from goldfish and mammalian neuropeptide gamma, as determined by 1H NMR spectroscopy.	Hydrogen	98-100	tachykinin precursor 1	Homo sapiens	61-79
12699375-2	2003	While both sn-1 and sn-2 binding modes are allowable in terms of hydrogen bonding, it has been found that in general, DAGs prefer to bind sn-1, while the corresponding analogous DAG lactones prefer to bind sn-2.	Hydrogen	65-73	solute carrier family 38 member 3	Homo sapiens	11-15
12699375-2	2003	While both sn-1 and sn-2 binding modes are allowable in terms of hydrogen bonding, it has been found that in general, DAGs prefer to bind sn-1, while the corresponding analogous DAG lactones prefer to bind sn-2.	Hydrogen	65-73	solute carrier family 38 member 5	Homo sapiens	20-24
12699376-19	2003	These structures reveal that the single amino acid difference in the ligand binding pocket (Ser277 in TRalpha or Asn331 in TRbeta) results in a slightly different hydrogen bonding pattern that may explain the increased beta-selectivity of 15.	Hydrogen	163-171	T cell receptor beta locus	Homo sapiens	123-129
12667488-4	2003	As evaluated using DNA binding or Western blotting assays, in IL-6-treated hepatocytes VO(4) had a modest enhancing effect on peak levels of cytoplasmic and nuclear PY-STAT3 reached by 1h and on their subsequent decline.	Hydrogen	185-187	signal transducer and activator of transcription 3	Homo sapiens	168-173
12676613-7	2003	Molecular modeling results suggest that hydrogen-bond energies and the maximum achievable interatomic distance between two terminal H-bond capable sites may influence both the potential to interact with the AR and the nature of the interaction (agonist vs. antagonist) within this series of chemicals.	Hydrogen	40-48	androgen receptor	Homo sapiens	207-209
12609744-7	2003	Furthermore, when H(2)O(2) (0.5 to 2 mM) was added to BAECs in static culture, the ECE-1 as well as ET-1 mRNA expression was attenuated in proportion to the concentration of H(2)O(2).	Hydrogen	18-22	endothelin 1	Homo sapiens	100-104
12649439-4	2003	These data were complemented by hydrogen/deuterium (H/D) exchange measurements, which illustrated enhanced protection of slowly-exchanging IL-2 NH protons near the site of interaction with IL-2Ralpha.	Hydrogen	32-40	interleukin 2	Homo sapiens	139-143
12595091-0	2003	Hydrogen-peroxide-induced heme degradation in red blood cells: the protective roles of catalase and glutathione peroxidase.	Hydrogen	0-8	catalase	Homo sapiens	87-95
12654307-0	2003	Polarographic direct determination and homogeneous immunoassay of anti-human serum albumin (HSA) by parallel catalytic hydrogen wave of anti-HSA or HSA.	Hydrogen	119-127	albumin	Homo sapiens	77-90
12475394-3	2003	Comparison of the binding and functional properties of related VIP analogues suggested that the VPAC(1) selectivity of Arg(11)-VIP was due to the loss of a hydrogen bond between the hydroxy group of Thr residue and the VPAC(2) receptor, steric hindrance between the Arg side chain and the VPAC(2) receptor and charge attraction by the VPAC(1) receptor.	Hydrogen	156-164	vasoactive intestinal peptide receptor 1	Homo sapiens	96-103
12475394-7	2003	These results support the hypothesis that the hydroxy group of the native VIP-Thr(11) side chain can indeed form a hydrogen bond with the Tyr side chain in the VPAC(2) receptor.	Hydrogen	115-123	vasoactive intestinal peptide	Homo sapiens	74-77
12654307-0	2003	Polarographic direct determination and homogeneous immunoassay of anti-human serum albumin (HSA) by parallel catalytic hydrogen wave of anti-HSA or HSA.	Hydrogen	119-127	albumin	Homo sapiens	92-95
12659192-4	2003	Hydrogen/deuterium (H/D) exchange of lysozyme in solution confirms that it is partially unfolded at pH 2.0 in water/methanol (v/v = 2/8).	Hydrogen	0-8	lysozyme	Homo sapiens	37-45
12654307-0	2003	Polarographic direct determination and homogeneous immunoassay of anti-human serum albumin (HSA) by parallel catalytic hydrogen wave of anti-HSA or HSA.	Hydrogen	119-127	albumin	Homo sapiens	141-144
12654307-0	2003	Polarographic direct determination and homogeneous immunoassay of anti-human serum albumin (HSA) by parallel catalytic hydrogen wave of anti-HSA or HSA.	Hydrogen	119-127	albumin	Homo sapiens	141-144
12654307-1	2003	Human serum albumin (HSA) or anti-human serum albumin (anti-HSA) yields a catalytic hydrogen wave at about -1.85V (vs Ag/AgCl) in 0.25M NH(3).H(2)O-NH(4)Cl (pH 8.58) buffer.	Hydrogen	84-92	albumin	Homo sapiens	6-19
12654307-1	2003	Human serum albumin (HSA) or anti-human serum albumin (anti-HSA) yields a catalytic hydrogen wave at about -1.85V (vs Ag/AgCl) in 0.25M NH(3).H(2)O-NH(4)Cl (pH 8.58) buffer.	Hydrogen	84-92	albumin	Homo sapiens	21-24
12654307-1	2003	Human serum albumin (HSA) or anti-human serum albumin (anti-HSA) yields a catalytic hydrogen wave at about -1.85V (vs Ag/AgCl) in 0.25M NH(3).H(2)O-NH(4)Cl (pH 8.58) buffer.	Hydrogen	84-92	albumin	Homo sapiens	40-53
12654307-1	2003	Human serum albumin (HSA) or anti-human serum albumin (anti-HSA) yields a catalytic hydrogen wave at about -1.85V (vs Ag/AgCl) in 0.25M NH(3).H(2)O-NH(4)Cl (pH 8.58) buffer.	Hydrogen	84-92	albumin	Homo sapiens	60-63
12654307-4	2003	Using the parallel catalytic hydrogen wave of anti-HSA or HSA in the presence of K(2)S(2)O(8), two sensitive methods for the determination of anti-HSA were developed.	Hydrogen	29-37	albumin	Homo sapiens	51-54
12654307-4	2003	Using the parallel catalytic hydrogen wave of anti-HSA or HSA in the presence of K(2)S(2)O(8), two sensitive methods for the determination of anti-HSA were developed.	Hydrogen	29-37	albumin	Homo sapiens	58-61
12654307-4	2003	Using the parallel catalytic hydrogen wave of anti-HSA or HSA in the presence of K(2)S(2)O(8), two sensitive methods for the determination of anti-HSA were developed.	Hydrogen	29-37	albumin	Homo sapiens	58-61
12654307-5	2003	One is a direct determination based on the parallel catalytic hydrogen wave of anti-HAS itself, and the other is a homogeneous immunoassay based on measuring the decrease of the peak current of the parallel catalytic hydrogen wave of HSA after homogeneous immunoreaction of HSA with anti-HSA.	Hydrogen	217-225	albumin	Homo sapiens	234-237
12654307-6	2003	In the direct determination, the second-order derivative peak current of the parallel catalytic hydrogen wave of anti-HSA itself is rectilinear to its titer in the range from 1:1.0 x 10(7) to 1:8.4 x 10(6).	Hydrogen	96-104	albumin	Homo sapiens	118-121
12654307-7	2003	In the homogeneous immunoassay, the decrease in the second-order derivative peak current of the parallel catalytic hydrogen wave of HSA is linearly related to the added anti-HSA in the titer range from 1:3.0 x 10(7) to 1:6.0 x 10(6).	Hydrogen	115-123	albumin	Homo sapiens	132-135
12654307-7	2003	In the homogeneous immunoassay, the decrease in the second-order derivative peak current of the parallel catalytic hydrogen wave of HSA is linearly related to the added anti-HSA in the titer range from 1:3.0 x 10(7) to 1:6.0 x 10(6).	Hydrogen	115-123	albumin	Homo sapiens	174-177
12652142-0	2003	1H, 13C and 15N backbone resonance assignments of the SAND domains from glucocorticoid modulatory element binding proteins-1 and -2.	Hydrogen	0-2	glucocorticoid modulatory element binding protein 1	Homo sapiens	72-131
12617670-4	2003	Crystallization from a boiling mixture of n-PrOH and water gave 1.6n-PrOH (monoclinic, P2(1)/c), which exhibits another type of 3-D hydrogen-bonded porous network (type B) via cyclic dimers as another hydrogen-bonding motif of six primary amide groups.	Hydrogen	132-140	cyclin dependent kinase inhibitor 1A	Homo sapiens	87-94
12617670-4	2003	Crystallization from a boiling mixture of n-PrOH and water gave 1.6n-PrOH (monoclinic, P2(1)/c), which exhibits another type of 3-D hydrogen-bonded porous network (type B) via cyclic dimers as another hydrogen-bonding motif of six primary amide groups.	Hydrogen	201-209	cyclin dependent kinase inhibitor 1A	Homo sapiens	87-94
12617670-7	2003	The crystal structure of 1.H(2)O (monoclinic, P2(1)/c), which was produced under hydrothermal conditions, showed a nonporous 3-D hydrogen-bonded network chain of amide groups (type C) composed of a mixed hydrogen bonding motif of helical catemer chains/cyclic dimer/catemer.	Hydrogen	129-137	cyclin dependent kinase inhibitor 1A	Homo sapiens	46-53
12617670-7	2003	The crystal structure of 1.H(2)O (monoclinic, P2(1)/c), which was produced under hydrothermal conditions, showed a nonporous 3-D hydrogen-bonded network chain of amide groups (type C) composed of a mixed hydrogen bonding motif of helical catemer chains/cyclic dimer/catemer.	Hydrogen	204-212	cyclin dependent kinase inhibitor 1A	Homo sapiens	46-53
12603151-3	2003	Similar studies of [Fe(II)(H(2)bip)(3)](2+) plus [Fe(III)(Hbip)(H(2)bip)(2)](2+) indicate that hydrogen-atom self-exchange (proton-coupled electron transfer) occurs with k(Fe,H.)	Hydrogen	95-103	heat shock protein family A (Hsp70) member 5	Homo sapiens	31-34
12603151-3	2003	Similar studies of [Fe(II)(H(2)bip)(3)](2+) plus [Fe(III)(Hbip)(H(2)bip)(2)](2+) indicate that hydrogen-atom self-exchange (proton-coupled electron transfer) occurs with k(Fe,H.)	Hydrogen	95-103	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	53-56
12603151-3	2003	Similar studies of [Fe(II)(H(2)bip)(3)](2+) plus [Fe(III)(Hbip)(H(2)bip)(2)](2+) indicate that hydrogen-atom self-exchange (proton-coupled electron transfer) occurs with k(Fe,H.)	Hydrogen	95-103	heat shock protein family A (Hsp70) member 5	Homo sapiens	59-62
12631267-5	2003	The productive position of tyrosine in TH.BH4 was stabilized by a hydrogen bond with BH4.	Hydrogen	66-74	tyrosine hydroxylase	Homo sapiens	39-41
12590920-3	2003	The solution structure and the residues important for membrane contact of the constrained PGIS F/G loop peptide were investigated by high-resolution 1H two-dimensional nuclear magnetic resonance (2D NMR) experiments and a spin label incorporation technique.	Hydrogen	149-151	prostaglandin I2 synthase	Homo sapiens	90-94
12609879-5	2003	The data suggest membrane dehydration by PLA(2) and the formation of PLA(2)-membrane hydrogen bonding.	Hydrogen	85-93	phospholipase A2 group IB	Homo sapiens	69-75
12609879-7	2003	Although membrane binding resulted in formation of more flexible alpha-helices in the native PLA(2), which corresponds to faster amide hydrogen exchange, the modified enzyme was more resistant to hydrogen exchange and experienced little structural change upon membrane binding.	Hydrogen	135-143	phospholipase A2 group IB	Homo sapiens	93-99
12609879-7	2003	Although membrane binding resulted in formation of more flexible alpha-helices in the native PLA(2), which corresponds to faster amide hydrogen exchange, the modified enzyme was more resistant to hydrogen exchange and experienced little structural change upon membrane binding.	Hydrogen	196-204	phospholipase A2 group IB	Homo sapiens	93-99
12595558-5	2003	These findings are compatible with crystallographic data showing that p52 has greater ability than p50 to form water molecule-mediated hydrogen bonds with inner nucleotide positions of the binding site.	Hydrogen	135-143	nuclear factor kappa B subunit 2	Homo sapiens	70-73
12651130-1	2003	Hydrogen exchange (HX) detected by mass spectrometry (MS) was used to analyze the structure of calcium-free alpha-lactalbumin, a model protein with marginal stability.	Hydrogen	0-8	lactalbumin alpha	Homo sapiens	108-125
12688532-7	2003	We conclude that a single nucleotide change in the primary structure of tRNA(i)Met made changes in hydration pattern and readjustment in hydrogen bonding which lead to a cleavage of the phosphodiester bond.	Hydrogen	137-145	mitochondrially encoded tRNA glycine	Homo sapiens	72-82
12641160-4	2003	Besides the above mentioned, CART was also able to select hydrogen-bonding and molecular complexity descriptors.	Hydrogen	58-66	CART prepropeptide	Homo sapiens	29-33
12482758-6	2003	AtGC1 contains the arginine or lysine that participates in hydrogen bonding with guanine and the cysteine that confers substrate specificity for GTP.	Hydrogen	59-67	guanylyl cyclase 1	Arabidopsis thaliana	0-5
12595558-5	2003	These findings are compatible with crystallographic data showing that p52 has greater ability than p50 to form water molecule-mediated hydrogen bonds with inner nucleotide positions of the binding site.	Hydrogen	135-143	nuclear factor kappa B subunit 1	Homo sapiens	99-102
12547806-1	2003	Dimerization of the transmembrane domain of glycophorin A is mediated by a seven residue motif LIxxGVxxGVxxT through a combination of van der Waals and hydrogen bonding interactions.	Hydrogen	152-160	glycophorin A (MNS blood group)	Homo sapiens	44-57
12693972-8	2003	According to our hypothesis, the induced absorption band is that of the imino form of ThDP resulting from three contributing features of the ThDP binding site of transketolase: the relative hydrophobicity of this site, hydrogen bonding of the N1;-atom of the ThDP aminopyrimidine ring to Glu418, and base stacking interactions between the aminopyrimidine ring of ThDP and Phe445.	Hydrogen	219-227	transketolase	Homo sapiens	162-175
12586353-1	2003	Sodium-hydrogen exchanger regulatory factor isoform-1 (NHERF-1) and NHERF-2 are two structurally related PDZ-domain-containing protein adapters that effectively transduce cyclic AMP (cAMP) signals that inhibit NHE3, the sodium-hydrogen exchanger isoform present at the apical surface of kidney and gut epithelia.	Hydrogen	7-15	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	Mus musculus	68-75
12586353-1	2003	Sodium-hydrogen exchanger regulatory factor isoform-1 (NHERF-1) and NHERF-2 are two structurally related PDZ-domain-containing protein adapters that effectively transduce cyclic AMP (cAMP) signals that inhibit NHE3, the sodium-hydrogen exchanger isoform present at the apical surface of kidney and gut epithelia.	Hydrogen	7-15	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	210-214
12393557-8	2003	The functional importance of CR2 was further demonstrated by its ability to substitute for H2 of VP16 in domain-swapping experiments to confer oncogenic activity on MLL.	Hydrogen	91-93	lysine (K)-specific methyltransferase 2A	Mus musculus	165-168
12604217-0	2003	Hydrogen bonding interactions between aldose reductase complexed with NADP(H) and inhibitor tolrestat studied by molecular dynamics simulations and binding assay.	Hydrogen	0-8	aldo-keto reductase family 1 member B	Homo sapiens	38-54
12615542-7	2003	The initial model was a beta strand where the hydrogen bonding, chain, and intersheet directions were placed along the a, b, and c axes.	Hydrogen	46-54	amyloid beta precursor protein	Homo sapiens	22-28
12540232-1	2003	Imidazo[1,2-a]pyridyl N-arylpyridazinones were hybridized from the classic pyridinylimidazoles and the more recent dual hydrogen bond acceptors, resulting in a new structural class of selective p38 MAP kinase inhibitors.	Hydrogen	120-128	mitogen-activated protein kinase 14	Homo sapiens	194-197
12525158-3	2003	Proteolytic digestion of the hydrogen/deuterium exchanged proteins showed that, in I-1 state, the helices C, D, E, and F incorporate more deuterium, whereas in HFIP-MG(N) the exchange rate is similar for all protein regions.	Hydrogen	29-37	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	83-86
12429743-9	2003	These results suggest that c-Src-dependent tyrosine phosphorylation of I kappa B alpha and subsequent activation of NF kappa B is controlled by intracellular H(2)O(2) and defines an important redox-regulated pathway for NF kappa B activation following H/R injury that is independent of the IKK complex.	Hydrogen	158-162	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	27-32
12441340-5	2003	The NMR analysis of L-PGDS revealed that the hydrogen-bond network was reorganized to be increased in the activity-enhanced state formed in the presence of 0.5 M GdnHCl or 1 m urea and to be decreased but still remain in the inactive intermediate observed in the presence of 2 M GdnHCl or 4 M urea.	Hydrogen	45-53	prostaglandin D2 synthase	Homo sapiens	20-26
12513077-4	2003	The presence of weak intermolecular hydrogen bonding [C-H---X(Cl or Br), C-H---N, or C-H---pi] interactions in 3-7 leads to the formation of polymeric architectures in the solid-state.	Hydrogen	36-44	nuclear receptor subfamily 4 group A member 3	Homo sapiens	73-80
12429743-9	2003	These results suggest that c-Src-dependent tyrosine phosphorylation of I kappa B alpha and subsequent activation of NF kappa B is controlled by intracellular H(2)O(2) and defines an important redox-regulated pathway for NF kappa B activation following H/R injury that is independent of the IKK complex.	Hydrogen	158-162	NFKB inhibitor alpha	Homo sapiens	71-86
12429743-9	2003	These results suggest that c-Src-dependent tyrosine phosphorylation of I kappa B alpha and subsequent activation of NF kappa B is controlled by intracellular H(2)O(2) and defines an important redox-regulated pathway for NF kappa B activation following H/R injury that is independent of the IKK complex.	Hydrogen	158-162	nuclear factor kappa B subunit 1	Homo sapiens	116-126
12429743-9	2003	These results suggest that c-Src-dependent tyrosine phosphorylation of I kappa B alpha and subsequent activation of NF kappa B is controlled by intracellular H(2)O(2) and defines an important redox-regulated pathway for NF kappa B activation following H/R injury that is independent of the IKK complex.	Hydrogen	158-162	nuclear factor kappa B subunit 1	Homo sapiens	220-230
12515556-5	2003	In the interaction of Src SH3 with VSLARRPLPPLP (VSL12) (K(d) 0.8 microM), Trp118 appears to form a strong hydrogen bond with VSL12, judging from significant intensity increases of the Trp Raman bands and the reported complex structure.	Hydrogen	107-115	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	22-25
12890925-4	2003	RESULTS: Heritability estimates (h2) indicate significant genetic effects on apoB (h2=0.46+/-0.05), LDL-C (h2=0.40+/-0.05), HDL-C (h2=0.47+/-0.05), and Tg (h2=0.35+/-0.05) (all p&lt;0.001).	Hydrogen	33-35	apolipoprotein B	Homo sapiens	77-81
12356333-8	2003	The rates of reduction of Fe(III), AQDS, U(VI) and fumarate were also the same in the wild type and ppcA mutant when hydrogen was supplied as the electron donor.	Hydrogen	117-125	cathepsin A	Homo sapiens	100-104
14682610-4	2003	Quantitative structure-activity relationships (QSARs) with substrate binding affinity based on KD values and inhibition data (Ki values) demonstrate the importance of hydrogen bonding, pi-pi stacking and relative molecular mass in describing variations in avidity towards the CYP2D6 enzyme, although the compound lipophilicity (log D(7.4)) appears to be the most important single descriptor for CYP2D6 inhibition.	Hydrogen	167-175	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	276-282
14682610-4	2003	Quantitative structure-activity relationships (QSARs) with substrate binding affinity based on KD values and inhibition data (Ki values) demonstrate the importance of hydrogen bonding, pi-pi stacking and relative molecular mass in describing variations in avidity towards the CYP2D6 enzyme, although the compound lipophilicity (log D(7.4)) appears to be the most important single descriptor for CYP2D6 inhibition.	Hydrogen	167-175	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	395-401
12890925-4	2003	RESULTS: Heritability estimates (h2) indicate significant genetic effects on apoB (h2=0.46+/-0.05), LDL-C (h2=0.40+/-0.05), HDL-C (h2=0.47+/-0.05), and Tg (h2=0.35+/-0.05) (all p&lt;0.001).	Hydrogen	83-85	apolipoprotein B	Homo sapiens	77-81
12890925-4	2003	RESULTS: Heritability estimates (h2) indicate significant genetic effects on apoB (h2=0.46+/-0.05), LDL-C (h2=0.40+/-0.05), HDL-C (h2=0.47+/-0.05), and Tg (h2=0.35+/-0.05) (all p&lt;0.001).	Hydrogen	33-35	component of oligomeric golgi complex 2	Homo sapiens	100-105
12487989-1	2002	Hydrogen exchange experiments show that cytochrome c and other proteins under native conditions reversibly unfold in a multi-step manner.	Hydrogen	0-8	cytochrome c, somatic	Homo sapiens	40-52
12450380-4	2002	Two lysine residues, Lys 206 and Lys 296, which form a hydrogen-bonded dilysine pair in human Tf, have been shown to strongly influence iron release from the N-lobe.	Hydrogen	55-63	transferrin	Homo sapiens	94-96
12444967-5	2002	Kinetic analysis of these ribozyme variants demonstrated the importance of the two W-C base pairs of P1.1 for cleavage; in addition, the results suggest that all hydrogen bond interactions detected in the crystal structure involving 2"-OH and N7 atoms are present in the active ribozyme structure.	Hydrogen	162-170	S100 calcium binding protein A10	Homo sapiens	101-105
12914175-1	2002	This article investigated UV, IR and 1H-NMR spectra characteristics of the complexes which are formed by glucosamine and Fe (II), Zn (II), Co (II), Cu (II) respectively.	Hydrogen	37-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-155
12244092-7	2002	Hydrophobic interactions and hydrogen-bonding interactions were observed in the structures between UCN-01 and the Chk1 kinase domain.	Hydrogen	29-37	checkpoint kinase 1	Homo sapiens	114-118
12495677-3	2002	Infection of HEp-2 cells with a strain of Streptococcus pyogenes capable to efficiently internalize HEp-2 cells (strain A40) resulted in translocation of NF-kappaB during the first 15 min of infection, reaching a peak after 30 min that persisted at slightly lower levels 1h thereafter.	Hydrogen	271-273	nuclear factor kappa B subunit 1	Homo sapiens	154-163
12205097-9	2002	The differential stabilities of nFGF-1 and hFGF-1 are attributed to the differences in the number of hydrogen bonds and the presence of solvent inaccessible cavities in the two proteins.	Hydrogen	101-109	fibroblast growth factor 1	Homo sapiens	43-49
12228253-7	2002	By contrast, the low affinity of SHBG for 2-hydroxyestradiol can be attributed to intra-molecular hydrogen bonding between the hydroxyls in the aromatic steroid ring A, which generates a steric clash with the amido group of Asn(82).	Hydrogen	98-106	sex hormone binding globulin	Homo sapiens	33-37
12379371-3	2002	Test 1 examined the ratio of LH secretion during the 1h before and 2h after naloxone (NAL) administration.	Hydrogen	53-55	serine protease 21	Homo sapiens	0-6
12228253-2	2002	The high affinity of SHBG for 2-MeOE2 relies primarily on hydrogen bonding between the hydroxyl at C-3 of 2-MeOE2 and Asp(65) and an interaction between the methoxy group at C-2 and the amido group of Asn(82).	Hydrogen	58-66	sex hormone binding globulin	Homo sapiens	21-25
12228253-6	2002	The higher affinity of SHBG for estradiol derivatives with a halogen atom at C-2 is due to either enhanced hydrogen bonding between the hydroxyl at C-3 and Asp(65) (2-fluoroestradiol) or accommodation of the functional group at C-2 (2-bromoestradiol), rather than an interaction with Asn(82).	Hydrogen	107-115	sex hormone binding globulin	Homo sapiens	23-27
12522317-0	2002	Assignment of backbone 1H, 13C, and 15N resonances of the SH2 domain of human Grb14.	Hydrogen	23-25	growth factor receptor bound protein 14	Homo sapiens	78-83
12414674-7	2002	Lys23, a conserved amino acid in the scorpion toxins, protrudes into the pore of the Kv1.2 channel and forms two hydrogen bonds with the conserved residues Gly401(D) and Tyr400(C) and one hydrophobic contact with Gly401(C) of the Kv1.2 channel.	Hydrogen	113-121	potassium voltage-gated channel subfamily A member 2	Homo sapiens	85-90
12414674-9	2002	In addition, six hydrogen-bonding interactions are formed between residues Lys23, Lys27, Lys30, and Tyr32 of MTX and residues Gly401, Tyr400, Asp402, Asp378, and Thr406 of Kv1.2.	Hydrogen	17-25	potassium voltage-gated channel subfamily A member 2	Homo sapiens	172-177
12234486-4	2002	Assays showed directly that recombinant ZPU1 (ZPU1r) expressed in Escherichia coli functions as a pullulanase-type enzyme, and 1H-NMR spectroscopy demonstrated that ZPU1r specifically hydrolyzes alpha(1--&gt;6) branch linkages.	Hydrogen	127-129	pullulanase-type starch debranching enzyme 1	Zea mays	40-44
12370832-4	2002	Mutagenesis-derived hydrogen bond disruption attenuated the interaction of p53 with the transactivation repressor Mdm-2 but had no direct effect on the interaction of p53 with the basal transcription factor TAF(II)31.	Hydrogen	20-28	tumor protein p53	Homo sapiens	75-78
12370832-6	2002	Consistently, p53-null cells transfected with hydrogen bond disrupting p53 mutants demonstrated enhanced endogenous p21 expression, whereas p53/Mdm-2-double null cells exhibited no discernible differences in p21 expression.	Hydrogen	46-54	tumor protein p53	Homo sapiens	14-17
12370832-6	2002	Consistently, p53-null cells transfected with hydrogen bond disrupting p53 mutants demonstrated enhanced endogenous p21 expression, whereas p53/Mdm-2-double null cells exhibited no discernible differences in p21 expression.	Hydrogen	46-54	tumor protein p53	Homo sapiens	71-74
12370832-6	2002	Consistently, p53-null cells transfected with hydrogen bond disrupting p53 mutants demonstrated enhanced endogenous p21 expression, whereas p53/Mdm-2-double null cells exhibited no discernible differences in p21 expression.	Hydrogen	46-54	cyclin dependent kinase inhibitor 1A	Homo sapiens	116-119
12370832-6	2002	Consistently, p53-null cells transfected with hydrogen bond disrupting p53 mutants demonstrated enhanced endogenous p21 expression, whereas p53/Mdm-2-double null cells exhibited no discernible differences in p21 expression.	Hydrogen	46-54	tumor protein p53	Homo sapiens	71-74
12370832-7	2002	We conclude disruption of intramolecular hydrogen bonding between Thr18 and Asp21 enhances p53 transactivation by modulating Mdm-2 binding, facilitating TAF(II)31 recruitment.	Hydrogen	41-49	tumor protein p53	Homo sapiens	91-94
12370832-7	2002	We conclude disruption of intramolecular hydrogen bonding between Thr18 and Asp21 enhances p53 transactivation by modulating Mdm-2 binding, facilitating TAF(II)31 recruitment.	Hydrogen	41-49	TATA-box binding protein associated factor 9	Homo sapiens	153-162
12370832-0	2002	Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.	Hydrogen	56-64	TATA-box binding protein associated factor 9	Homo sapiens	18-27
12370832-0	2002	Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.	Hydrogen	56-64	tumor protein p53	Homo sapiens	93-96
12234486-4	2002	Assays showed directly that recombinant ZPU1 (ZPU1r) expressed in Escherichia coli functions as a pullulanase-type enzyme, and 1H-NMR spectroscopy demonstrated that ZPU1r specifically hydrolyzes alpha(1--&gt;6) branch linkages.	Hydrogen	127-129	pullulanase-type starch debranching enzyme 1	Zea mays	165-170
12650588-3	2002	Molecular models of the complexes formed by indomethacin, sulindac, fenamates, 2-phenylpropionic acids and selective cyclooxygenase-2 (COX-2) inhibitors with the cyclooxygenase active site of human PGHS-2 have been built, paying particular attention to water molecules that participate in the hydrogen-bonding network at the polar active site entrance.	Hydrogen	293-301	prostaglandin-endoperoxide synthase 2	Homo sapiens	135-140
12495037-0	2002	1H, 13C and 15N resonance assignments of the human phosphatase PRL-3.	Hydrogen	0-2	protein tyrosine phosphatase 4A3	Homo sapiens	63-68
12192067-3	2002	Most of the amide hydrogens in the loop between the beta1 and beta4 sheets exhibited fast or moderately fast exchange, whereas in the amino acid 63-67 loop, located at the interface of the two subunits, the exchange was slow.	Hydrogen	18-27	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	52-67
12477485-2	2002	It is shown that known hGR ligands which induce the human cytochrome P450 enzyme CYP3A4 are able to fit the putative ligand-binding site of the nuclear hormone receptor and form hydrogen bonds with key amino acid residues within the binding pocket.	Hydrogen	178-186	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87
12237460-5	2002	In the case of H-FABP, the pH- and temperature-dependent behavior of selected side-chain resonances (Ser82 OgH and the imidazole ring protons of His93) indicated an unusually slow exchange with the solvent, implying that the intricate hydrogen-bonding network of amino-acid side-chains and water molecules in the protein interior is very rigid.	Hydrogen	235-243	fatty acid binding protein 3	Homo sapiens	15-21
12196629-0	2002	Cytochrome c folding pathway: kinetic native-state hydrogen exchange.	Hydrogen	51-59	cytochrome c, somatic	Homo sapiens	0-12
12197759-6	2002	Our calculations indicate that, in the AChE-ACh Michaelis complex, only two hydrogen bonds are formed between the carbonyl oxygen of ACh and the peptidic NH groups of Gly121 and Gly122.	Hydrogen	76-84	acetylcholinesterase (Cartwright blood group)	Homo sapiens	39-43
12449423-0	2002	1H, 15N and 13C resonance assignments for the DNA-binding domain of myocyte nuclear factor (Foxk1).	Hydrogen	0-2	forkhead box K1	Homo sapiens	68-90
12449423-0	2002	1H, 15N and 13C resonance assignments for the DNA-binding domain of myocyte nuclear factor (Foxk1).	Hydrogen	0-2	forkhead box K1	Homo sapiens	92-97
12396061-1	2002	Novel complexes of Co(II), Ni(II), Cu(II) and Pd(II) with the new ligand [N,N"-bis(2-carboxy-1-oxo-phenelenyl)ethylenediamine] (H2L) have been synthesized and characterized on the basis of elemental analyses, magnetic susceptibility, thermal, infrared, electronic, 1H NMR and EPR spectral studies.	Hydrogen	265-267	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
12118009-2	2002	In the present study, we investigate the stability of hFGF-1 by hydrogen-deuterium exchange as a function of urea concentration.	Hydrogen	64-72	fibroblast growth factor 1	Homo sapiens	54-60
12118009-4	2002	Hydrogen exchange in hFGF-1, under the experimental conditions used, occurs by the EX2 mechanism.	Hydrogen	0-8	fibroblast growth factor 1	Homo sapiens	21-27
12118009-5	2002	In contrast to the equilibrium unfolding events monitored by optical probes, native state hydrogen exchange data show that the beta-trefoil architecture of hFGF-1 does not behave as a single cooperative unit.	Hydrogen	90-98	fibroblast growth factor 1	Homo sapiens	156-162
12224920-1	2002	The equilibrium constant for binding of dimethyl phosphate to a Co(III) complex in water increases from 6.2 to 210 M-1 upon addition of a single hydrogen bond between the bound phosphate and the metal complex.	Hydrogen	145-153	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	64-71
12197713-2	2002	We analyzed the chemical shift modulation contribution of labile hydrogens in bovine pancreatic trypsin inhibitor (BPTI) to the transverse 1H spin relaxation rate, R2, of the bulk solvent.	Hydrogen	65-74	trophoblast Kunitz domain protein 1	Bos taurus	96-113
12197713-2	2002	We analyzed the chemical shift modulation contribution of labile hydrogens in bovine pancreatic trypsin inhibitor (BPTI) to the transverse 1H spin relaxation rate, R2, of the bulk solvent.	Hydrogen	139-141	trophoblast Kunitz domain protein 1	Bos taurus	96-113
12469807-13	2002	A mobility gradient of intercalated poly(ethylene oxide), PEO, segments is proven in 1H-3Si WISE experiments with spin diffusion.	Hydrogen	85-87	twinkle mtDNA helicase	Homo sapiens	58-61
12916171-10	2002	It is shown that polyamines stabilizes the inter-domain interface of p50 protein due to appearance of additional electrostatic and hydrogen bonds.	Hydrogen	131-139	nuclear factor kappa B subunit 1	Homo sapiens	69-72
12166938-11	2002	These studies suggested that the high CB1 affinity of the R,R stereoisomer is due to the ability of the headgroup to form an intramolecular hydrogen bond between the carboxamide oxygen and the headgroup hydroxyl that orients the C2 and C1" methyl groups to have hydrophobic interactions with valine 3.32(196), while the carboxamide oxygen forms a hydrogen bond with lysine 3.28(192) at CB1.	Hydrogen	347-355	cannabinoid receptor 1	Homo sapiens	38-41
12176048-4	2002	MSUM, CPPD, and fMLP stimulated a significant adherence of neutrophils to hOB after a 1h incubation.	Hydrogen	86-88	formyl peptide receptor 1	Homo sapiens	16-20
12065592-3	2002	Substitution of specific residues within the SHBG steroid-binding site confirmed that Ser(42) plays a key role in determining high affinity interactions by hydrogen bonding to functional groups at C3 of the androstanediols and levonorgestrel and the hydroxyl at C17 of estradiol.	Hydrogen	156-164	sex hormone binding globulin	Homo sapiens	45-49
12169661-1	2002	Na+/H+ exchanger regulatory factor (NHERF)-1 and NHERF-2, two structurally related protein adapters containing tandem PSD-95/Discs large/ZO-1 (PDZ) domains, were identified as essential factors for protein kinase A-mediated inhibition of the sodium-hydrogen exchanger, NHE3.	Hydrogen	249-257	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	Mus musculus	49-56
12169661-1	2002	Na+/H+ exchanger regulatory factor (NHERF)-1 and NHERF-2, two structurally related protein adapters containing tandem PSD-95/Discs large/ZO-1 (PDZ) domains, were identified as essential factors for protein kinase A-mediated inhibition of the sodium-hydrogen exchanger, NHE3.	Hydrogen	249-257	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	269-273
12166938-11	2002	These studies suggested that the high CB1 affinity of the R,R stereoisomer is due to the ability of the headgroup to form an intramolecular hydrogen bond between the carboxamide oxygen and the headgroup hydroxyl that orients the C2 and C1" methyl groups to have hydrophobic interactions with valine 3.32(196), while the carboxamide oxygen forms a hydrogen bond with lysine 3.28(192) at CB1.	Hydrogen	140-148	cannabinoid receptor 1	Homo sapiens	38-41
12166938-11	2002	These studies suggested that the high CB1 affinity of the R,R stereoisomer is due to the ability of the headgroup to form an intramolecular hydrogen bond between the carboxamide oxygen and the headgroup hydroxyl that orients the C2 and C1" methyl groups to have hydrophobic interactions with valine 3.32(196), while the carboxamide oxygen forms a hydrogen bond with lysine 3.28(192) at CB1.	Hydrogen	140-148	cannabinoid receptor 1	Homo sapiens	386-389
12166938-11	2002	These studies suggested that the high CB1 affinity of the R,R stereoisomer is due to the ability of the headgroup to form an intramolecular hydrogen bond between the carboxamide oxygen and the headgroup hydroxyl that orients the C2 and C1" methyl groups to have hydrophobic interactions with valine 3.32(196), while the carboxamide oxygen forms a hydrogen bond with lysine 3.28(192) at CB1.	Hydrogen	347-355	cannabinoid receptor 1	Homo sapiens	386-389
12145051-6	2002	These results suggest that anesthetics reduce the apparent agonist Kd of the nAChR by binding to a site that has a dipolarity and ability to accept hydrogen bonds that are similar to those of water, but a hydrogen bond-donating capacity that is less.	Hydrogen	148-156	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	77-82
12167006-2	2002	Hydrogen bonding between a ligand and a particular amino acid residue is identified from a comparison of activation energies measured for the complex of the unmodified scFv and the corresponding mutant.	Hydrogen	0-8	immunglobulin heavy chain variable region	Homo sapiens	168-172
12145051-6	2002	These results suggest that anesthetics reduce the apparent agonist Kd of the nAChR by binding to a site that has a dipolarity and ability to accept hydrogen bonds that are similar to those of water, but a hydrogen bond-donating capacity that is less.	Hydrogen	205-213	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	77-82
12145051-7	2002	IMPLICATIONS: Anesthetics representing a wide range of chemical classes reduce the apparent agonist dissociation constant of the Torpedo nicotinic acetylcholine receptor with aqueous potencies that are governed by their molecular volumes and hydrogen bond basicities.	Hydrogen	242-250	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	137-169
12146634-4	2002	The chief solute factors that control logKoc, log P, and logk" (on soil and on C18) are the solute size (V(I)/100) and hydrogen-bond basicity (betam).	Hydrogen	119-127	Bardet-Biedl syndrome 9	Homo sapiens	79-82
11925441-0	2002	Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17.	Hydrogen	110-118	ATP binding cassette subfamily B member 1	Homo sapiens	45-75
12398353-0	2002	1H, 15N and 13C resonance assignments of yeast Saccharomyces cerevisiae calmodulin in the Ca2+-free state.	Hydrogen	0-2	calmodulin	Saccharomyces cerevisiae S288C	72-82
12376574-3	2002	In CD(3)OD/D(2)O, 91:9 (v/v), containing 2 mM ammonium acetate, SP-C(Leu) and SP-C exchanged 40% of their exchangeable hydrogens within 1 min.	Hydrogen	119-128	surfactant protein C	Homo sapiens	78-82
12376574-5	2002	After approximately 300 h, four exchangeable hydrogen atoms in SP-C(Leu) and 10 in SP-C remained unexchanged.	Hydrogen	45-53	surfactant protein C	Homo sapiens	63-67
12203347-0	2002	Ab initio studies on the mechanism of the size-dependent hydrogen-loss reaction in Mg+(H2O)n. The mechanism of size-dependent intracluster hydrogen loss in the cluster ions Mg(+)(H(2)O)(n), which is switched on around n=6, and off around n=14, was studied by ab initio calculations at the MP2/6-31G* and MP2/6-31G** levels for n=1-6.	Hydrogen	57-65	major intrinsic protein of lens fiber	Homo sapiens	289-294
12203347-0	2002	Ab initio studies on the mechanism of the size-dependent hydrogen-loss reaction in Mg+(H2O)n. The mechanism of size-dependent intracluster hydrogen loss in the cluster ions Mg(+)(H(2)O)(n), which is switched on around n=6, and off around n=14, was studied by ab initio calculations at the MP2/6-31G* and MP2/6-31G** levels for n=1-6.	Hydrogen	57-65	major intrinsic protein of lens fiber	Homo sapiens	304-309
12203347-0	2002	Ab initio studies on the mechanism of the size-dependent hydrogen-loss reaction in Mg+(H2O)n. The mechanism of size-dependent intracluster hydrogen loss in the cluster ions Mg(+)(H(2)O)(n), which is switched on around n=6, and off around n=14, was studied by ab initio calculations at the MP2/6-31G* and MP2/6-31G** levels for n=1-6.	Hydrogen	139-147	major intrinsic protein of lens fiber	Homo sapiens	289-294
12203347-0	2002	Ab initio studies on the mechanism of the size-dependent hydrogen-loss reaction in Mg+(H2O)n. The mechanism of size-dependent intracluster hydrogen loss in the cluster ions Mg(+)(H(2)O)(n), which is switched on around n=6, and off around n=14, was studied by ab initio calculations at the MP2/6-31G* and MP2/6-31G** levels for n=1-6.	Hydrogen	139-147	major intrinsic protein of lens fiber	Homo sapiens	304-309
12203347-8	2002	Delocalization of the electron on the singly occupied molecular orbital (SOMO) away from the Mg(+) ion is observed for the hexamer core structure, while at the same time this isomer is the most reactive for the hydrogen-loss reaction, with an energy barrier of only 2.7 kcal mol(-1) at the MP2/6-31G** level.	Hydrogen	211-219	major intrinsic protein of lens fiber	Homo sapiens	290-295
12074582-4	2002	The overall structure of BTCe was stabilized by three disulfide bonds, a hydrophobic core, and 23 hydrogen bonds.	Hydrogen	98-106	betacellulin	Homo sapiens	25-29
12074600-4	2002	The predicted proline-rich protein consists of 432 amino acid residues with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus.	Hydrogen	107-109	complement component 4 binding protein alpha	Homo sapiens	14-34
12376574-3	2002	In CD(3)OD/D(2)O, 91:9 (v/v), containing 2 mM ammonium acetate, SP-C(Leu) and SP-C exchanged 40% of their exchangeable hydrogens within 1 min.	Hydrogen	119-128	surfactant protein C	Homo sapiens	64-68
12230195-4	2002	This membrane technology supported excellent NO3- and nitrite (NO2-) removal once H2 and carbon limitations were corrected.	Hydrogen	82-84	NBL1, DAN family BMP antagonist	Homo sapiens	45-48
12230195-5	2002	The membrane module achieved a maximum H2 flux of 1.79 x 10(-2) mg H2/m2 s, which was sufficient to completely remove 16.4 mg/L NO3(-)-N from a synthetic groundwater with no NO2- accumulation.	Hydrogen	39-41	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
12230195-5	2002	The membrane module achieved a maximum H2 flux of 1.79 x 10(-2) mg H2/m2 s, which was sufficient to completely remove 16.4 mg/L NO3(-)-N from a synthetic groundwater with no NO2- accumulation.	Hydrogen	67-69	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
12079394-2	2002	In the Src SH3 domain transition state, these regions are stabilized by a hydrogen bond between Glu30 in the diverging turn and Ser47 in the distal loop.	Hydrogen	74-82	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	7-10
12238597-0	2002	Assignments of the 1H, 13C, and 15N resonances of the winged helix domain of the proto-oncoprotein cQin (FoxG1B).	Hydrogen	19-21	forkhead box G1	Homo sapiens	105-111
12188129-0	2002	Effects of C18 long chain fatty acids on glucose, butyrate and hydrogen degradation.	Hydrogen	63-71	Bardet-Biedl syndrome 9	Homo sapiens	11-14
11925441-2	2002	We previously demonstrated that two hydrogen-bonding amino acid residues in the predicted transmembrane 17 (TM17) of MRP1, Thr(1242) and Trp(1246), were important for drug resistance and 17beta-estradiol 17-(beta-d-glucuronide) (E(2)17betaG) transport.	Hydrogen	36-44	ATP binding cassette subfamily B member 1	Homo sapiens	117-121
12099307-4	2002	An index of insulin sensitivity derived from the clamp (IS(CLAMP)) was obtained from glucose infusion rates adjusted for change in fat free mass and endogenous glucose production measured using [6,6(-2)H2]-glucose.	Hydrogen	202-204	insulin	Homo sapiens	12-19
11937361-9	2002	In both CPA small middle dot complexes, the phenyl ring in is fitted in the substrate recognition pocket at the S(1)" subsite, and the carboxylate of the inhibitors forms bifurcated hydrogen bonds with the guanidinium moiety of Arg-145 and a hydrogen bond with the guanidinium of Arg-127.	Hydrogen	182-190	carboxypeptidase A1	Homo sapiens	8-11
11937361-9	2002	In both CPA small middle dot complexes, the phenyl ring in is fitted in the substrate recognition pocket at the S(1)" subsite, and the carboxylate of the inhibitors forms bifurcated hydrogen bonds with the guanidinium moiety of Arg-145 and a hydrogen bond with the guanidinium of Arg-127.	Hydrogen	242-250	carboxypeptidase A1	Homo sapiens	8-11
11937361-10	2002	In the complex of CPA small middle dotD-, the carboxylate of the inhibitor is engaged in hydrogen bonding with the phenolic hydroxyl of the down-positioned Tyr-248.	Hydrogen	89-97	carboxypeptidase A1	Homo sapiens	18-21
12033911-6	2002	In [K(1,10-diaza-18-crown-6)][cis-IrH(4)(PPh(3))(2)], the potassium bonds to two hydrides so that one NH can form an intra-ion-pair protonic-hydridic hydrogen bond while the other forms an inter-ion-pair NH.HIr hydrogen bond to form chains through the lattice.	Hydrogen	150-158	caveolin 1	Homo sapiens	41-47
12033911-6	2002	In [K(1,10-diaza-18-crown-6)][cis-IrH(4)(PPh(3))(2)], the potassium bonds to two hydrides so that one NH can form an intra-ion-pair protonic-hydridic hydrogen bond while the other forms an inter-ion-pair NH.HIr hydrogen bond to form chains through the lattice.	Hydrogen	211-219	caveolin 1	Homo sapiens	41-47
12083555-3	2002	By 1H-NMR measurements, PEO and H2O protons show an absorption peak around 3.6 ppm and 4.5 ppm, respectively.	Hydrogen	3-5	twinkle mtDNA helicase	Homo sapiens	24-27
12222686-4	2002	These contacts, which are different in Msh2 and Msh6, likely facilitate stacking and hydrogen bonding interactions between side chains in Msh6 and the mismatched base, thus stabilizing a kinked DNA conformation that permits subsequent repair steps coordinated by the Mlh1-Pms1 heterodimer.	Hydrogen	85-93	mismatch repair ATPase MSH2	Saccharomyces cerevisiae S288C	39-43
12222686-4	2002	These contacts, which are different in Msh2 and Msh6, likely facilitate stacking and hydrogen bonding interactions between side chains in Msh6 and the mismatched base, thus stabilizing a kinked DNA conformation that permits subsequent repair steps coordinated by the Mlh1-Pms1 heterodimer.	Hydrogen	85-93	ATP-binding mismatch repair protein	Saccharomyces cerevisiae S288C	272-276
12021429-1	2002	The epitope of a monoclonal antibody raised against human thrombin has been determined by hydrogen/deuterium exchange coupled to MALDI mass spectrometry.	Hydrogen	90-98	coagulation factor II, thrombin	Homo sapiens	58-66
12021433-0	2002	Structural features of interferon-gamma aggregation revealed by hydrogen exchange.	Hydrogen	64-72	interferon gamma	Homo sapiens	23-39
12005500-1	2002	The Fe(III) and Co(III) complexes of the ligand N-(2-picolyl)picolinamide (pmpH; H represents the dissociable amide hydrogen), namely, [Fe(pmp)(2)]BF(4) (1) and [Co(pmp)(2)]ClO(4) (2), have been synthesized and structurally characterized.	Hydrogen	116-124	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	7-10
12010066-1	2002	Blackbody infrared radiative dissociation (BIRD) and functional group replacement are used to map the location and strength of hydrogen bonds between an antibody single chain fragment (scFv) and its natural trisaccharide receptor, alpha-D-Galp (1--&gt;2)[alpha-D-Abep (1--&gt;3)]alpha-D-Manp1--&gt;OMe (1), in the gaseous, multiply protonated complex.	Hydrogen	127-135	immunglobulin heavy chain variable region	Homo sapiens	185-189
12009397-11	2002	Fibronectin aggregation is driven by the formation of intermolecular hydrogen bonds responsible for intermolecular beta sheet structures.	Hydrogen	69-77	fibronectin 1	Homo sapiens	0-11
12005500-1	2002	The Fe(III) and Co(III) complexes of the ligand N-(2-picolyl)picolinamide (pmpH; H represents the dissociable amide hydrogen), namely, [Fe(pmp)(2)]BF(4) (1) and [Co(pmp)(2)]ClO(4) (2), have been synthesized and structurally characterized.	Hydrogen	116-124	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	16-23
11982365-3	2002	The method of calculation is based on the use of dimethyl phosphate as a reference state for evaluating relative pK(a) values, and on the optimization of the oxygen and acidic hydrogen van der Waals radii to give reasonable pK(1)(a), pK(2)(a), and pK(3)(a) for phosphoric acid in solution.	Hydrogen	176-184	pyruvate kinase L/R	Homo sapiens	224-229
12126645-2	2002	Injection of TNF (10 microg) to mice did markedly increase the number of platelet-derived microparticles in plasma, most pronounced 1h after injection.	Hydrogen	132-134	tumor necrosis factor	Mus musculus	13-16
12126645-3	2002	Injection of TNF induced a transient activation of platelet caspases, -1, -3, -6, -8, -9, as seen by the binding of caspases probes detected by flow cytometry, most pronounced 1h after injection.	Hydrogen	176-178	tumor necrosis factor	Mus musculus	13-16
11950482-6	2002	(2) After application of hCG for 1h, vasoconstriction by ANG II was significantly attenuated in MA.	Hydrogen	33-35	angiotensinogen	Homo sapiens	57-63
11993993-6	2002	As for the glycophorin A structure, we find backbone-to-backbone atomic contacts of the C alpha-H...O type in each of these 26 helix-helix interactions that display the stereochemical hallmarks of hydrogen bond formation.	Hydrogen	197-205	glycophorin A (MNS blood group)	Homo sapiens	11-24
11993993-7	2002	These glycophorin A-like helix-helix interactions are enriched in the general set of helix-helix interactions containing the GXXXG motif, suggesting that the inferred C alpha-H...O hydrogen bonds stabilize the helix-helix interactions.	Hydrogen	181-189	glycophorin A (MNS blood group)	Homo sapiens	6-19
11980473-6	2002	The frequency of this vibration is lower in eNOS than in P450(cam) and CPO, which can be explained by differences in hydrogen bonding to the proximal cysteine heme ligand.	Hydrogen	117-125	calmodulin 3	Homo sapiens	57-66
11964235-0	2002	Implications of threonine hydrogen bonding in the glycophorin A transmembrane helix dimer.	Hydrogen	26-34	glycophorin A (MNS blood group)	Homo sapiens	50-63
11886805-2	2002	Molecular substitutions were specifically designed to investigate the role of hydrogen bonding at the active site of ALR2.	Hydrogen	78-86	aldo-keto reductase family 1 member B	Homo sapiens	117-121
11886805-5	2002	The results, discussed in terms of balance between free energies of solvation and free energies of binding to ALR2, elucidate the importance of hydrogen bonding with Thr113 and with Trp111 and cofactor, and provide a rationale to the observed differences in binding affinities.	Hydrogen	144-152	aldo-keto reductase family 1 member B	Homo sapiens	110-114
11955010-3	2002	In most crystal structures of actin, the delta1-nitrogen of the methylated H73 forms a hydrogen bond with the carbonyl of G158.	Hydrogen	87-95	actin	Saccharomyces cerevisiae S288C	30-35
11971685-2	2002	1H NMR data indicate that the aziridine binds about three times more tightly to (S,S)L-Co(III) than to (R,R)L-Co(III).	Hydrogen	0-2	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	87-94
11971685-2	2002	1H NMR data indicate that the aziridine binds about three times more tightly to (S,S)L-Co(III) than to (R,R)L-Co(III).	Hydrogen	0-2	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	110-117
11961113-5	2002	The success of these validations suggests that a P-gp pharmacophore for 27 inhibitors of digoxin transport in Caco-2 cells consisted of four hydrophobes and one hydrogen bond acceptor.	Hydrogen	161-169	ATP binding cassette subfamily B member 1	Homo sapiens	49-53
11961113-7	2002	A third pharmacophore generated with 17 inhibitors of vinblastine accumulation in P-gp expressing LLC-PK1 cells contained four hydrophobes and one hydrogen bond acceptor.	Hydrogen	147-155	ATP binding cassette subfamily B member 1	Homo sapiens	82-86
11961113-8	2002	A final pharmacophore was generated for inhibition of calcein accumulation in P-gp expressing LLC-PK1 cells and found to contain two hydrophobes, a ring aromatic feature, and a hydrogen bond donor.	Hydrogen	177-185	ATP binding cassette subfamily B member 1	Homo sapiens	78-82
11943390-2	2002	Samples of GCP with hydrophobicity decreasing in the order GCP12&gt;GCP11&gt;GCP21 were synthesised and characterised by 1H NMR.	Hydrogen	121-123	golgin B1	Homo sapiens	11-14
11942823-0	2002	Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics.	Hydrogen	77-85	seed linoleate 13S-lipoxygenase-1	Glycine max	49-63
11942823-1	2002	The hydrogen-atom transfer in soybean lipoxygenase-1 (SLO) exhibits a large kinetic isotope effect on k(cat) (KIE = 81) near room temperature and a very weak temperature dependence (E(act) = 2.1 kcal/mol).	Hydrogen	4-12	seed linoleate 13S-lipoxygenase-1	Glycine max	38-52
11926819-3	2002	The replacement of Tyr160 on the F-helix of alpha1-antitrypsin to alanine results in the loss of a conserved hydrogen bond that dramatically reduces the stability of the protein to both heat and solvent denaturation, indicating the importance of Tyr160 in the stability of the molecule.	Hydrogen	109-117	serpin family A member 1	Homo sapiens	44-62
11955010-6	2002	In the closed-to-open transition in beta-actin, both of these hydrogen bonds are broken as the phosphate tail is exposed to solvent.	Hydrogen	62-70	actin	Saccharomyces cerevisiae S288C	41-46
11917017-9	2002	The non-detectable DNA binding of the 273H p53-CD is due mainly to the disruption of a hydrogen-bonding network involving R273, D281 and R280, leading to a loss of major groove binding by R280 and K120.	Hydrogen	87-95	tumor protein p53	Homo sapiens	43-46
11792457-6	2002	Mitochondrial membrane potential as well as the protein levels of Bcl-2 and Bcl-x(L) decreased 15-60 min and 1-3 h after the exposure to NaCN (1mM, 1h), respectively.	Hydrogen	148-150	BCL2, apoptosis regulator	Gallus gallus	66-71
12033392-2	2002	METHODS: DHP was oxidized by hydrogen peroxide, t-butylhydroperoxide, or peroxyl radicals derived from the thermal decomposition of 2,2"-azobis(2-amidinopropane) dihydrochloride (AAPH) in 40% (v/v) organic cosolvent and 5 mM buffer at or near 40 degrees C. Interactions between DHP and ]propane sulfonic acid and imidazole) and DH- were assessed by 1H-NMR spectroscopy.	Hydrogen	349-351	dihydropyrimidinase	Homo sapiens	9-12
11906285-6	2002	Binding of 9alpha-fluorocortisol to the AR(ccr) involves favorable hydrogen bond patterns on the C17 and C21 substituents of the ligand due to the mutations at 701 and 877 in the AR(ccr).	Hydrogen	67-75	androgen receptor	Homo sapiens	40-47
11906285-6	2002	Binding of 9alpha-fluorocortisol to the AR(ccr) involves favorable hydrogen bond patterns on the C17 and C21 substituents of the ligand due to the mutations at 701 and 877 in the AR(ccr).	Hydrogen	67-75	androgen receptor	Homo sapiens	179-186
11863429-0	2002	Direct detection of hydrogen bonds in monomeric superoxide dismutase: biological implications.	Hydrogen	20-28	superoxide dismutase 1	Homo sapiens	48-68
11887182-1	2002	Hydrogen exchange experiments monitored by NMR and mass spectrometry reveal that the amyloidogenic D67H mutation in human lysozyme significantly reduces the stability of the beta-domain and the adjacent C-helix in the native structure.	Hydrogen	0-8	lysozyme	Homo sapiens	122-130
11958479-7	2002	Molecular modeling studies indicate that the energy-minimized structure of 3,4-dihydroxymandelaldehyde bound to aldose reductase is similar to that of glyceraldehyde where the 2"-hydroxyl group forms hydrogen bonds with Trp111 and NADPH.	Hydrogen	200-208	aldo-keto reductase family 1 member B	Homo sapiens	112-128
11863429-1	2002	Hydrogen bonds were directly determined via NMR with different experimental approaches at 600 and 800 MHz for reduced monomeric superoxide dismutase (Q133M2SOD, 16 kDa).	Hydrogen	0-8	superoxide dismutase 1	Homo sapiens	128-148
11866578-15	2002	The pair of analytical expressions are used to calculate ring current contributions to the CSA (Deltasigma) of 1H(N) backbone amide resonances in a structure of the second type 2 module from the protein fibronectin.	Hydrogen	111-113	fibronectin 1	Homo sapiens	203-214
11851407-1	2002	Amide hydrogen exchange has been used to examine the structural dynamics and energetics of the interaction of a peptide corresponding to the calmodulin-binding domain of smooth muscle myosin light chain kinase (smMLCKp) with calcium-saturated calmodulin.	Hydrogen	6-14	calmodulin 1	Homo sapiens	141-151
11855980-3	2002	An ATP binding site model, derived by homology from the FGFR-1 tyrosine kinase crystal structure suggesting hydrogen bonds of one indole NH and the methanone oxygen with the backbone carbonyl and amide, respectively, of Cys684, explains why only one indole moiety is open for substitution and locates groups in the 5- or 6-position outside the pocket.	Hydrogen	108-116	fibroblast growth factor receptor 1	Homo sapiens	56-62
11851407-1	2002	Amide hydrogen exchange has been used to examine the structural dynamics and energetics of the interaction of a peptide corresponding to the calmodulin-binding domain of smooth muscle myosin light chain kinase (smMLCKp) with calcium-saturated calmodulin.	Hydrogen	6-14	calmodulin 1	Homo sapiens	243-253
12188021-9	2002	Binding to largely hydrophobic sites, such as the active site of p38, was significantly improved by introducing a correction factor selectively affecting only carbon and hydrogen energy grids, thus, providing an effective, although approximate, treatment of solvation.	Hydrogen	170-178	mitogen-activated protein kinase 14	Homo sapiens	65-68
11897155-8	2002	We postulate that the improved signaling properties of [Arg(11)]PTH(1-11) over wild type PTH(1-11) is due to a stable hydrogen bond between Arg(11) and E444, at the beginning of TM7.	Hydrogen	118-126	parathyroid hormone	Homo sapiens	64-67
11897155-8	2002	We postulate that the improved signaling properties of [Arg(11)]PTH(1-11) over wild type PTH(1-11) is due to a stable hydrogen bond between Arg(11) and E444, at the beginning of TM7.	Hydrogen	118-126	parathyroid hormone	Homo sapiens	89-92
11834591-6	2002	In the HS group, a small decrease in EAAT1-immunoreactivity (IR) was observed in CA4 and in the polymorphic and supragranular layer of the dentate gyrus, compared with the control group.	Hydrogen	7-9	solute carrier family 1 member 3	Homo sapiens	37-42
11738625-2	2002	1H NMR spectroscopy allows unambiguous assignment of the stereochemistry at C-10 in these dimers.	Hydrogen	0-2	homeobox C10	Homo sapiens	76-80
11917147-3	2002	The proposed alpha-helix structure for the SS1 segment, analyzed through molecular dynamics simulations in aqueous-phase, was validated by the plotting of Ramachandran diagrams for the averaged structures and by the analysis of i and i + 4 helical hydrogen bonding between the amino acid residues.	Hydrogen	248-256	major histocompatibility complex, class II, DR beta 1	Homo sapiens	43-46
11852248-3	2002	Whereas earlier proposed binding mechanisms relied almost entirely on a hydrogen bond match between the AFP and ice, it now seems probable that van der Waals and hydrophobic interactions make a significant contribution to the enthalpy of adsorption.	Hydrogen	72-80	alpha fetoprotein	Homo sapiens	104-107
11790100-5	2002	In this study, the three-dimensional structure of reduced apo-S100A1 was determined by NMR spectroscopy using a total of 2220 NOE distance constraints, 258 dihedral angle constraints, and 168 backbone hydrogen bond constraints derived from a series of 2D, 3D, and 4D NMR experiments.	Hydrogen	201-209	S100 calcium binding protein A1	Homo sapiens	62-68
11786020-4	2002	The second main receptor determinant is the hydroxyl group of Y183 forming a hydrogen bond with IL-4 E9 in cluster I.	Hydrogen	77-85	interleukin 4	Homo sapiens	96-100
11782202-5	2002	The FB1-cholesterol complex was reinforced by NaCl but was destabilized by NaF, a salt known to break hydrogen bonds.	Hydrogen	102-110	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
11811423-5	2002	After formation of the sol-gel, the bonds linking the spacer template to the matrix were cleaved in a manner that generated a pocket of the appropriate size bordered by amine groups that could aid in the binding of DDT through weak hydrogen bonding interactions.	Hydrogen	232-240	D-dopachrome tautomerase	Homo sapiens	215-218
11989718-8	2002	Evaluation of the interaction surfaces, including hydrophobic patch, shape, hydrogen bonding, and electrostatic compatibility, strongly suggested that the drosophila insulin receptor is a substrate of the DPTP.	Hydrogen	76-84	Protein tyrosine phosphatase 61F	Drosophila melanogaster	205-209
11979597-3	2002	The Raman spectra of CRP-(cAMP)(1) and CRP-(cAMP)(2) extracted from those of CRP-cAMP mixtures at varied mixing ratios clearly show that the hydrogen bonding state and the conformation of cAMP in both complexes in solution are very similar to those found in the X-ray crystal structure of CRP-(cAMP)(2), which is evidence that the cAMP binding mode does not differ between the two complexes.	Hydrogen	141-149	C-reactive protein	Homo sapiens	21-24
11979597-3	2002	The Raman spectra of CRP-(cAMP)(1) and CRP-(cAMP)(2) extracted from those of CRP-cAMP mixtures at varied mixing ratios clearly show that the hydrogen bonding state and the conformation of cAMP in both complexes in solution are very similar to those found in the X-ray crystal structure of CRP-(cAMP)(2), which is evidence that the cAMP binding mode does not differ between the two complexes.	Hydrogen	141-149	C-reactive protein	Homo sapiens	39-42
11979597-3	2002	The Raman spectra of CRP-(cAMP)(1) and CRP-(cAMP)(2) extracted from those of CRP-cAMP mixtures at varied mixing ratios clearly show that the hydrogen bonding state and the conformation of cAMP in both complexes in solution are very similar to those found in the X-ray crystal structure of CRP-(cAMP)(2), which is evidence that the cAMP binding mode does not differ between the two complexes.	Hydrogen	141-149	C-reactive protein	Homo sapiens	39-42
11979597-3	2002	The Raman spectra of CRP-(cAMP)(1) and CRP-(cAMP)(2) extracted from those of CRP-cAMP mixtures at varied mixing ratios clearly show that the hydrogen bonding state and the conformation of cAMP in both complexes in solution are very similar to those found in the X-ray crystal structure of CRP-(cAMP)(2), which is evidence that the cAMP binding mode does not differ between the two complexes.	Hydrogen	141-149	C-reactive protein	Homo sapiens	39-42
11834591-8	2002	In the non-HS group, increased EAAT2-IR was detected in the CA1 and CA2 field, compared with non-epileptic controls.	Hydrogen	11-13	solute carrier family 1 member 2	Homo sapiens	31-36
11834591-10	2002	Fewer EAAT3-positive cells were found in the HS group than in the non-HS and control group.	Hydrogen	45-47	solute carrier family 1 member 1	Homo sapiens	6-11
11834591-10	2002	Fewer EAAT3-positive cells were found in the HS group than in the non-HS and control group.	Hydrogen	70-72	solute carrier family 1 member 1	Homo sapiens	6-11
11834591-12	2002	In the HS group, the percentage of EAAT3-IR neurones was increased in CA2 and in the granule cell layer of the dentate gyrus.	Hydrogen	7-9	solute carrier family 1 member 1	Homo sapiens	35-40
11834591-16	2002	The results indicate an upregulation of EAAT2 protein expression in CA1 and CA2 in neurones in the non-HS group.	Hydrogen	103-105	solute carrier family 1 member 2	Homo sapiens	40-45
11834591-17	2002	This is in line with decreased EAAT2 protein levels in the HS group, since these hippocampi are characterized by severe neuronal cell loss.	Hydrogen	59-61	solute carrier family 1 member 2	Homo sapiens	31-36
11744605-0	2002	Computational models for cytochrome P450: a predictive electronic model for aromatic oxidation and hydrogen atom abstraction.	Hydrogen	99-107	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	25-40
11856334-5	2002	In contrast, OH-2 and -3 of the reducing sugar contribute to transition-state stabilization, by 5.8 and 4.1 kJ.mol-1, respectively, suggesting that these groups participate in neutral hydrogen bonds.	Hydrogen	184-192	thiamine thiazole synthase	Saccharomyces cerevisiae S288C	111-116
11858641-8	2002	Analysis of the structural and the energetic data provides evidence supporting that network of hydrogen bonds between Tyr355, Glu524, Arg120 and Arg513 might be involved in mediating the binding of the time-dependent inhibitors of PGHS-2.	Hydrogen	95-103	prostaglandin-endoperoxide synthase 2	Homo sapiens	231-237
11746698-3	2002	In addition, the N-terminal domain of p57 is both functionally independent as a cyclin A-CDK2 inhibitor and unstructured, as demonstrated by circular dichroism and fluorescence spectra indicative of unfolded proteins, a lack of 1H chemical shift dispersion and a hydrodynamic radius consistent with a highly unfolded structure.	Hydrogen	228-230	cyclin dependent kinase inhibitor 1C	Homo sapiens	38-41
11742125-0	2002	Early formation of a beta hairpin during folding of staphylococcal nuclease H124L as detected by pulsed hydrogen exchange.	Hydrogen	104-112	amyloid beta precursor protein	Homo sapiens	19-25
12200855-7	2002	Finally, the Western blotting results verified that the levels of protein expression of CDK2, cyclin A and cyclin E were relatively high in alpha 1H transfectants compared to control cultures.	Hydrogen	146-148	cyclin A2	Homo sapiens	94-102
12408104-6	2002	As with rhodopsin, conformational signaling appears to depend on the rearrangement of key electrostatic, hydrogen-bond, and hydrophobic interactions that normally serve to stabilize the inactive LHR conformation.	Hydrogen	105-113	rhodopsin	Homo sapiens	8-17
11755203-8	2001	Hydrogen bonds and hydrophobic interaction appear to be important in the binding of these inhibitors to EGFR.	Hydrogen	0-8	epidermal growth factor receptor	Homo sapiens	104-108
11602601-5	2001	Furthermore, correlation of the selectivity characteristics of the SGLT isoforms (SGLT1 transports both glucose and galactose, but SGLT2 and SGLT3 transport only glucose) with amino acid sequence differences, suggests that residue 460 (threonine in SGLT1, and serine in SGLT2 and SGLT3) are involved in hydrogen bonding to O4 of the pyranose.	Hydrogen	303-311	solute carrier family 5 member 1	Homo sapiens	82-87
11602601-5	2001	Furthermore, correlation of the selectivity characteristics of the SGLT isoforms (SGLT1 transports both glucose and galactose, but SGLT2 and SGLT3 transport only glucose) with amino acid sequence differences, suggests that residue 460 (threonine in SGLT1, and serine in SGLT2 and SGLT3) are involved in hydrogen bonding to O4 of the pyranose.	Hydrogen	303-311	solute carrier family 5 member 1	Homo sapiens	249-254
11677137-3	2001	The molecular modeling study for CPA(2R,3R)-3 complex suggested that the lone pair electrons on the nitrogen of the aziridine ring in the inhibitor forms a coordinative bond with the active site zinc ion and the proton on the nitrogen is engaged in hydrogen bonding with one of the carboxylate oxygens of Glu-270.	Hydrogen	249-257	carboxypeptidase A1	Homo sapiens	33-36
11591710-10	2001	We suggest that non-native hydrogen bonds between protein molecules within aggregates of recombinant human growth hormone are responsible for the rate-limiting kinetic barrier in pressure-induced disaggregation.	Hydrogen	27-35	growth hormone 1	Homo sapiens	107-121
11708930-1	2001	The phenolic "A-ring" of natural and synthetic estrogen receptor (ER) ligands was effectively replaced by a planar six-member ring formed through an intramolecular hydrogen bond within a salicylaldoxime.	Hydrogen	164-172	estrogen receptor 1	Homo sapiens	47-64
11708930-1	2001	The phenolic "A-ring" of natural and synthetic estrogen receptor (ER) ligands was effectively replaced by a planar six-member ring formed through an intramolecular hydrogen bond within a salicylaldoxime.	Hydrogen	164-172	estrogen receptor 1	Homo sapiens	66-68
11641390-6	2001	Purified Msh2-Msh6 with substitutions in the conserved Phe(337) and Glu(339) in Msh6 thought to stack or hydrogen bond, respectively, with the mismatched base do have reduced DNA binding affinity but normal ATPase activity.	Hydrogen	105-113	mismatch repair ATPase MSH2	Saccharomyces cerevisiae S288C	9-13
11641390-7	2001	Moreover, wild-type Msh2-Msh6 binds with lower affinity to mismatches with thymine replaced by difluorotoluene, which lacks the ability to hydrogen bond.	Hydrogen	139-147	mismatch repair ATPase MSH2	Saccharomyces cerevisiae S288C	20-24
11641390-8	2001	The results suggest that yeast Msh2-Msh6 interacts asymmetrically with the DNA through base-specific stacking and hydrogen bonding interactions and backbone contacts.	Hydrogen	114-122	mismatch repair ATPase MSH2	Saccharomyces cerevisiae S288C	31-35
11724565-3	2001	The type II tandem G.U pairs have a combination of wobble and bifurcated hydrogen bonds where the uracil 2-carbonyl oxygen is hydrogen-bonded to both G,H1 and G,H2.	Hydrogen	126-134	growth hormone 1	Homo sapiens	150-160
11717483-7	2001	Water molecules and O-H groups of CA10 form an extended network with cooperative O-H...O-H...O-H hydrogen bonds.	Hydrogen	97-105	carbonic anhydrase 10	Homo sapiens	34-38
11597414-1	2001	Several benzimidazole derivatives have been identified as potent thrombin receptor (PAR-1) antagonists as represented by compound 1h, which showed an IC(50) of 33 nM.	Hydrogen	130-132	coagulation factor II thrombin receptor	Homo sapiens	84-89
11749586-5	2001	The C-2 and C-22 hydroxyls are identified as hydrogen-bond acceptor sites which enhance activity.	Hydrogen	45-53	anon-17Cb	Drosophila melanogaster	4-7
11763065-2	2001	The results of the voltammetric measurements showed that the presence of both PTU and Co(II) gives rise to a new irreversible peak at about -1.5 V. Based upon our previous results obtained in the study of other sulfur compounds and the sulfide ion itself, the peak was ascribed to the catalytic hydrogen evolution superimposed on the reduction of the coordinated Co(II) ion.	Hydrogen	295-303	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
11763065-2	2001	The results of the voltammetric measurements showed that the presence of both PTU and Co(II) gives rise to a new irreversible peak at about -1.5 V. Based upon our previous results obtained in the study of other sulfur compounds and the sulfide ion itself, the peak was ascribed to the catalytic hydrogen evolution superimposed on the reduction of the coordinated Co(II) ion.	Hydrogen	295-303	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	363-369
11731301-9	2001	The increase in selectivity results from the displacement of a single bound water molecule common to the S1 site of both the uPA target and the tPA anti-target because of the ensuing deficit in hydrogen bonding of the arylamidine inhibitor when bound in the Ala190 protease anti-target.	Hydrogen	194-202	plasminogen activator, urokinase	Homo sapiens	125-128
11731301-9	2001	The increase in selectivity results from the displacement of a single bound water molecule common to the S1 site of both the uPA target and the tPA anti-target because of the ensuing deficit in hydrogen bonding of the arylamidine inhibitor when bound in the Ala190 protease anti-target.	Hydrogen	194-202	plasminogen activator, tissue type	Homo sapiens	144-147
11911269-0	2001	Differentiation of the P-gp and MRP1 multidrug resistance systems by mobile lipid 1H-NMR spectroscopy and phosphatidylserine externalization.	Hydrogen	82-84	ATP binding cassette subfamily B member 1	Homo sapiens	23-27
11911269-0	2001	Differentiation of the P-gp and MRP1 multidrug resistance systems by mobile lipid 1H-NMR spectroscopy and phosphatidylserine externalization.	Hydrogen	82-84	ATP binding cassette subfamily C member 1	Homo sapiens	32-36
11735996-2	2001	We have investigated the dynamics of protons along chains of hydrogen-bonded water molecules adsorbed on the surface of the globular protein lysozyme.	Hydrogen	61-69	lysozyme	Homo sapiens	141-149
11604254-9	2001	There are two types of binding sites in the albumin for PA1; with the electrostatic forces being discarded, the hydrophobic and hydrogen bond are more probable.	Hydrogen	128-136	PAXIP1 associated glutamate rich protein 1	Homo sapiens	56-59
11711890-2	2001	Phosphorylation of Akt (serine-473) was enhanced in cortex after 1-hour ischemia, and also after 1h and 6 h of reperfusion, but it returned back to that in controls by 24 h. After this first wave of Akt activation, a second increase was observed between 4 and 7 days.	Hydrogen	97-99	AKT serine/threonine kinase 1	Homo sapiens	19-22
11576542-3	2001	The conformational coupling between the transmembrane span and the cytoplasmic domain of PMP1 was investigated from 1H-nuclear magnetic resonance data of two synthetic fragments: F9-F38, i.e. 80% of the whole sequence, and Y25-F38, the isolated cytoplasmic domain.	Hydrogen	116-118	peroxisomal biogenesis factor 19	Homo sapiens	89-93
11576779-8	2001	The beta-ligand modulation efficiency could also be correlated to Pgp structural recognition elements such as hydrogen bonding potential, the presence of a basic nitrogen and planar aromatic ring.	Hydrogen	110-118	ATP binding cassette subfamily B member 1	Homo sapiens	66-69
11463790-15	2001	They demonstrate that Thr(297), Phe(302), and Ser(305) of the fourth EC domain of GRPR are the critical residues for determining GRPR selectivity and suggest that both receptor-ligand cation-pi interactions and hydrogen bonding are important for their high affinity interaction.	Hydrogen	211-219	gastrin releasing peptide receptor	Homo sapiens	82-86
11559075-5	2001	NMe4(+), NEt4(+), and NPr4(+) all suit this purpose, and in addition the cluster exhibits a preference in the binding of these three guests: NEt4(+) is bound 300 times more strongly than NPr4(+), which is in turn bound 4 times more strongly than NMe4(+), as determined by 1H NMR spectroscopy.	Hydrogen	272-274	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	0-4
11559075-5	2001	NMe4(+), NEt4(+), and NPr4(+) all suit this purpose, and in addition the cluster exhibits a preference in the binding of these three guests: NEt4(+) is bound 300 times more strongly than NPr4(+), which is in turn bound 4 times more strongly than NMe4(+), as determined by 1H NMR spectroscopy.	Hydrogen	272-274	tetraspanin 5	Homo sapiens	9-13
11559075-5	2001	NMe4(+), NEt4(+), and NPr4(+) all suit this purpose, and in addition the cluster exhibits a preference in the binding of these three guests: NEt4(+) is bound 300 times more strongly than NPr4(+), which is in turn bound 4 times more strongly than NMe4(+), as determined by 1H NMR spectroscopy.	Hydrogen	272-274	tetraspanin 5	Homo sapiens	141-145
11559075-5	2001	NMe4(+), NEt4(+), and NPr4(+) all suit this purpose, and in addition the cluster exhibits a preference in the binding of these three guests: NEt4(+) is bound 300 times more strongly than NPr4(+), which is in turn bound 4 times more strongly than NMe4(+), as determined by 1H NMR spectroscopy.	Hydrogen	272-274	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	246-250
11575777-7	2001	Structural analysis (e.g., covalent N-H bond lengthening) indicates that the hydrogen bond between H3A and 08 of imidazole and betaine respectively (HB2) is slightly stronger than the bond between H1A and O1A of imidazole and picric acid (HB1), although HB1 is shorter than HB2: (dN...O(HB1)= 2.614(1) A, dN...O(HB2) = 2.684(1) A, dH...O(HB1) = 1.630(1) A, dH...O(HB2)= 1.635(1) A, dN-H(HB1) = 1.046(1) A, dN-H(HB2) = 1.057(1) A).	Hydrogen	77-85	histocompatibility minor HB-1	Homo sapiens	239-242
11575777-7	2001	Structural analysis (e.g., covalent N-H bond lengthening) indicates that the hydrogen bond between H3A and 08 of imidazole and betaine respectively (HB2) is slightly stronger than the bond between H1A and O1A of imidazole and picric acid (HB1), although HB1 is shorter than HB2: (dN...O(HB1)= 2.614(1) A, dN...O(HB2) = 2.684(1) A, dH...O(HB1) = 1.630(1) A, dH...O(HB2)= 1.635(1) A, dN-H(HB1) = 1.046(1) A, dN-H(HB2) = 1.057(1) A).	Hydrogen	77-85	histocompatibility minor HB-1	Homo sapiens	254-257
11575777-7	2001	Structural analysis (e.g., covalent N-H bond lengthening) indicates that the hydrogen bond between H3A and 08 of imidazole and betaine respectively (HB2) is slightly stronger than the bond between H1A and O1A of imidazole and picric acid (HB1), although HB1 is shorter than HB2: (dN...O(HB1)= 2.614(1) A, dN...O(HB2) = 2.684(1) A, dH...O(HB1) = 1.630(1) A, dH...O(HB2)= 1.635(1) A, dN-H(HB1) = 1.046(1) A, dN-H(HB2) = 1.057(1) A).	Hydrogen	77-85	histocompatibility minor HB-1	Homo sapiens	254-257
11575777-7	2001	Structural analysis (e.g., covalent N-H bond lengthening) indicates that the hydrogen bond between H3A and 08 of imidazole and betaine respectively (HB2) is slightly stronger than the bond between H1A and O1A of imidazole and picric acid (HB1), although HB1 is shorter than HB2: (dN...O(HB1)= 2.614(1) A, dN...O(HB2) = 2.684(1) A, dH...O(HB1) = 1.630(1) A, dH...O(HB2)= 1.635(1) A, dN-H(HB1) = 1.046(1) A, dN-H(HB2) = 1.057(1) A).	Hydrogen	77-85	histocompatibility minor HB-1	Homo sapiens	254-257
11575777-7	2001	Structural analysis (e.g., covalent N-H bond lengthening) indicates that the hydrogen bond between H3A and 08 of imidazole and betaine respectively (HB2) is slightly stronger than the bond between H1A and O1A of imidazole and picric acid (HB1), although HB1 is shorter than HB2: (dN...O(HB1)= 2.614(1) A, dN...O(HB2) = 2.684(1) A, dH...O(HB1) = 1.630(1) A, dH...O(HB2)= 1.635(1) A, dN-H(HB1) = 1.046(1) A, dN-H(HB2) = 1.057(1) A).	Hydrogen	77-85	histocompatibility minor HB-1	Homo sapiens	254-257
11516798-10	2001	After pre-treatment with TPA for 1h, the TPA-induced COX-2 mRNA was suppressed by treatment with DEX for 1 or 2h incubation in a dose-dependent manner.	Hydrogen	33-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	53-58
11559355-0	2001	Hydrogen exchange of the tetramerization domain of the human tumour suppressor p53 probed by denaturants and temperature.	Hydrogen	0-8	tumor protein p53	Homo sapiens	79-82
11559355-1	2001	We have analysed the hydrogen/deuterium exchange of the tetramerization domain of human tumour suppressor p53 under mild chemical denaturation conditions, and at different temperatures.	Hydrogen	21-29	tumor protein p53	Homo sapiens	106-109
11502182-2	2001	Hydrogen bonding of these water molecules to the protein backbone or side chains may contribute favorably to the Ca2+ affinity, as suggested in an earlier study of two calbindin D(9k) mutants [E60D and E60Q; Linse et al.	Hydrogen	0-8	S100 calcium binding protein G	Homo sapiens	168-182
11518539-0	2001	Probing subtle differences in the hydrogen exchange behavior of variants of the human alpha-lactalbumin molten globule using mass spectrometry.	Hydrogen	34-42	lactalbumin alpha	Homo sapiens	86-103
11502182-0	2001	Symmetrical stabilization of bound Ca2+ ions in a cooperative pair of EF-hands through hydrogen bonding of coordinating water molecules in calbindin D(9k).	Hydrogen	87-95	S100 calcium binding protein G	Homo sapiens	139-153
11583160-8	2001	These results indicate that alterations in either the hydrogen bond between Tyr138 and Glu82 or contact interactions between aromatic amino acid side chains have the potential to initiate the structural collapse of CaM normally associated with target protein binding and activation.	Hydrogen	54-62	calmodulin 1	Homo sapiens	215-218
11495587-0	2001	Development of serine protease inhibitors displaying a multicentered short (&lt;2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.	Hydrogen	87-95	coagulation factor II, thrombin	Homo sapiens	15-30
11583154-2	2001	We have used 1H NMR spectroscopy to determine the high-resolution structure of human ITF, which has allowed detailed structural comparisons with the other trefoil cell motility factors.	Hydrogen	13-15	trefoil factor 3	Homo sapiens	85-88
11485457-4	2001	Formation of 36 takes place through a 1,5-hydrogen migration of the initially formed radical, a kind of process that has been observed for the first time in the S(RN)1 propagation steps.	Hydrogen	42-50	NPHS2 stomatin family member, podocin	Homo sapiens	161-167
11563561-0	2001	Assignment of 1H, 13C and 15N resonances of the a" domain of ERp57.	Hydrogen	14-16	protein disulfide isomerase family A member 3	Homo sapiens	61-66
11565846-5	2001	The study leads to propose a model for the dimeric association of the transmembrane domains of the oncogenic neu receptor showing left-handed interactions of the two helices stabilized by symmetrical hydrogen bonding interactions involving the Glu side chain on one helix and the facing carbonyl of Ala661 on the second helix.	Hydrogen	200-208	erb-b2 receptor tyrosine kinase 2	Homo sapiens	109-112
11554538-3	2001	We also analyzed the formation of intramolecular H-bonds of 5-methyl 4-N-[n-[6-(p-bromobenzamido) caproyl amino]alk-1-yl]-2"-deoxycytidine compounds, and confirmed their presence by 1H-NMR studies.	Hydrogen	182-184	secretory leukocyte peptidase inhibitor	Homo sapiens	112-117
11587644-7	2001	A comparison of the novel PPARalpha/AZ 242 complex with the PPARgamma/AZ 242 complex and previously solved PPARgamma structures reveals a conserved hydrogen bonding network between agonists and the AF2 helix.	Hydrogen	148-156	peroxisome proliferator activated receptor gamma	Homo sapiens	60-69
11468348-2	2001	In the structure, four out of the six hypervariable loops of the Fab (complementarity determining regions [CDRs] L1, H1, H2, and H3) are involved in peptide association through hydrogen bonding, salt bridge formation, and hydrophobic interactions.	Hydrogen	177-185	L1 cell adhesion molecule	Homo sapiens	113-131
11468363-5	2001	Phosphate binds to the catalytic site of both Ang and Q117G in essentially the same manner observed in the RNase A-phosphate complex, forming hydrogen bonds with the side chains of His 13, His 114, and Gln 12, and the main chain of Leu 115; it makes an additional interaction with the Lys 40 ammonium group in the Ang complex.	Hydrogen	142-150	ribonuclease pancreatic	Bos taurus	107-114
11587644-7	2001	A comparison of the novel PPARalpha/AZ 242 complex with the PPARgamma/AZ 242 complex and previously solved PPARgamma structures reveals a conserved hydrogen bonding network between agonists and the AF2 helix.	Hydrogen	148-156	peroxisome proliferator activated receptor gamma	Homo sapiens	107-116
11427889-0	2001	Interhelical hydrogen bonds in the CFTR membrane domain.	Hydrogen	13-21	CF transmembrane conductance regulator	Homo sapiens	35-39
11444967-7	2001	Both the competition with a known active site-directed ARI and the protective effect on AR inactivation by N-bromosuccinimide showed that the isomers bind to the active site of the enzyme, but the thermodynamic parameters for the binding to AR indicated that additional hydrogen bonds and/or van der Waals interactions contribute to the energetic stabilization in the E-R-isomer complex.	Hydrogen	270-278	aldo-keto reductase family 1 member B	Homo sapiens	88-90
11444967-8	2001	Molecular modeling, together with the deductions from spectroscopic studies, suggested that the succinimide ring and the 4-bromo-2-fluorobenzyl group of the R-isomer are optimally located for formation of a hydrogen-bonding network with AR, and that the latter benzyl group is also effective for the differentiation between AR and aldehyde reductase (a closely related enzyme).	Hydrogen	207-215	aldo-keto reductase family 1 member B	Homo sapiens	237-239
11444967-8	2001	Molecular modeling, together with the deductions from spectroscopic studies, suggested that the succinimide ring and the 4-bromo-2-fluorobenzyl group of the R-isomer are optimally located for formation of a hydrogen-bonding network with AR, and that the latter benzyl group is also effective for the differentiation between AR and aldehyde reductase (a closely related enzyme).	Hydrogen	207-215	aldo-keto reductase family 1 member B	Homo sapiens	324-326
11448682-4	2001	The 1H NMR spectrum in DMSO-d(6) shows that OH-2(g) is deprotonated and the signal of OH-1(f) is shifted strongly downfield by complexation with Co(III).	Hydrogen	4-6	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	145-152
11453698-0	2001	Origin of apparent fast and non-exponential kinetics of lysozyme folding measured in pulsed hydrogen exchange experiments.	Hydrogen	92-100	lysozyme	Homo sapiens	56-64
11427889-3	2001	Analysis of gel migration patterns of these constructs, in conjunction with circular dichroism spectroscopy, demonstrate that a neutral-to-charged, CF-phenotypic point mutation of a hydrophobic residue (V232D) in the CFTR transmembrane (TM) helix 4 induces a hydrogen bond with neighboring wild type Gln 207 in TM helix 3.	Hydrogen	259-267	CF transmembrane conductance regulator	Homo sapiens	217-221
11427889-4	2001	As an electrostatic crosslink within a hydrocarbon phase, such a hydrogen bond could alter the normal assembly and alignment of CFTR TM helices and/or impede their movement in response to substrate transport.	Hydrogen	65-73	CF transmembrane conductance regulator	Homo sapiens	128-132
11389637-2	2001	These experimental data establish that the ArNO enophile attacks the olefinic substrate along the novel skew trajectory, with preferred hydrogen abstraction at the corner (twix regioselectivity).	Hydrogen	136-144	cytohesin 2	Homo sapiens	43-47
11419947-9	2001	Thus, the role of LA is to hold Glc by hydrogen bonding with the O-1 hydroxyl group in the acceptor-binding site on beta4Gal-T1, while the N-acetyl group-binding pocket in beta4Gal-T1 adjusts to maximize the interactions with the Glc molecule.	Hydrogen	39-47	lactalbumin alpha	Homo sapiens	18-20
11414818-1	2001	Catalysis of (18)O exchange between CO(2) and water catalyzed by a Co(II)-substituted mutant of human carbonic anhydrase II is analyzed to show the rate of release of H(2)(18)O from the active site.	Hydrogen	167-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11304524-5	2001	Remarkably, the guanido group of arginine at position -1 of the CFTR peptide forms two salt bridges and two hydrogen bonds with PDZ1 residues Glu(43) and Asn(22), respectively, providing the structural basis for the contribution of the penultimate amino acid of the peptide ligand to the affinity of the interaction.	Hydrogen	108-116	CF transmembrane conductance regulator	Homo sapiens	64-68
11340654-1	2001	Weakly polar interactions between aromatic rings of amino acids and hydrogens of backbone amides (Ar-HN) have been shown to support local structures in proteins.	Hydrogen	68-77	Rho family GTPase 2	Homo sapiens	98-103
11356331-4	2001	The 15N/1H HSQC spectrum of XPA-EM closely maps onto the 15N/1H HSQC spectrum of XPA-MBD, suggesting the DNA-binding domain is intact in the larger XPA fragment.	Hydrogen	8-10	XPA, DNA damage recognition and repair factor	Homo sapiens	28-31
11356331-4	2001	The 15N/1H HSQC spectrum of XPA-EM closely maps onto the 15N/1H HSQC spectrum of XPA-MBD, suggesting the DNA-binding domain is intact in the larger XPA fragment.	Hydrogen	61-63	XPA, DNA damage recognition and repair factor	Homo sapiens	28-31
11356331-4	2001	The 15N/1H HSQC spectrum of XPA-EM closely maps onto the 15N/1H HSQC spectrum of XPA-MBD, suggesting the DNA-binding domain is intact in the larger XPA fragment.	Hydrogen	61-63	XPA, DNA damage recognition and repair factor	Homo sapiens	81-84
11356331-4	2001	The 15N/1H HSQC spectrum of XPA-EM closely maps onto the 15N/1H HSQC spectrum of XPA-MBD, suggesting the DNA-binding domain is intact in the larger XPA fragment.	Hydrogen	61-63	XPA, DNA damage recognition and repair factor	Homo sapiens	81-84
11356331-5	2001	Such a conclusion is corroborated by chemical shift mapping experiments of XPA-EM with a single strand DNA oligomer, dCCAATAACC (d9), that show the same set of 15N/1H HSQC cross peaks are effected by the addition of DNA.	Hydrogen	164-166	XPA, DNA damage recognition and repair factor	Homo sapiens	75-78
12947681-2	2001	1H NMR chemical shift non-equivalence of the methyl doublet of alpha-phenylethylamine was 0.08 ppm(base-line separation) in solvent CDCl3, when the concentration of the sample was 0.051 mol.L-1, the molar ratio between chiral solvating agent and the sample was 0.33.	Hydrogen	0-2	immunoglobulin kappa variable 1-16	Homo sapiens	190-193
12947682-4	2001	The results suggest that pulsed electric field exposure as heat exposure will after conformation of insulin molecular by breaking some hydrogen bonds and recombining another hydrogen bonds.	Hydrogen	135-143	insulin	Homo sapiens	100-107
12947682-4	2001	The results suggest that pulsed electric field exposure as heat exposure will after conformation of insulin molecular by breaking some hydrogen bonds and recombining another hydrogen bonds.	Hydrogen	174-182	insulin	Homo sapiens	100-107
11356331-6	2001	However, relative to DNA-free XPA-MBD, the 15N/1H HSQC cross peaks of many of the basic residues in the loop-rich subdomain of DNA-free XPA-EM are less intense, or gone altogether, suggesting the acidic ERRC1-binding region of XPA-EM may associate transiently with the basic DNA-binding surface.	Hydrogen	47-49	XPA, DNA damage recognition and repair factor	Homo sapiens	136-139
11356331-6	2001	However, relative to DNA-free XPA-MBD, the 15N/1H HSQC cross peaks of many of the basic residues in the loop-rich subdomain of DNA-free XPA-EM are less intense, or gone altogether, suggesting the acidic ERRC1-binding region of XPA-EM may associate transiently with the basic DNA-binding surface.	Hydrogen	47-49	XPA, DNA damage recognition and repair factor	Homo sapiens	136-139
11340654-4	2001	Ar-HN interactions were identified by calculating the chemical shift of the amide hydrogen caused by the proximal aromatic ring.	Hydrogen	82-90	Rho family GTPase 2	Homo sapiens	0-5
11389952-7	2001	A low number of endothelial cells expressed surface E-selectin as early as 1h post-stimulation and surface expression was sustained after both stimuli for 24-72h.	Hydrogen	75-77	selectin E	Bos taurus	52-62
11341833-0	2001	Short, strong hydrogen bonds at the active site of human acetylcholinesterase: proton NMR studies.	Hydrogen	14-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-77
11350059-2	2001	In daphnodorin A-human chymase complex, daphnodorin A was fixed to the active site via hydrogen bonds with Ala177, Phe29, and Gly199 in human chymase, and it formed hydrogen bonds with Ser182 and Gly180, and this complex was formed stably.	Hydrogen	87-95	chymase 1	Homo sapiens	23-30
11350059-2	2001	In daphnodorin A-human chymase complex, daphnodorin A was fixed to the active site via hydrogen bonds with Ala177, Phe29, and Gly199 in human chymase, and it formed hydrogen bonds with Ser182 and Gly180, and this complex was formed stably.	Hydrogen	87-95	chymase 1	Homo sapiens	142-149
11350059-2	2001	In daphnodorin A-human chymase complex, daphnodorin A was fixed to the active site via hydrogen bonds with Ala177, Phe29, and Gly199 in human chymase, and it formed hydrogen bonds with Ser182 and Gly180, and this complex was formed stably.	Hydrogen	165-173	chymase 1	Homo sapiens	23-30
11350059-2	2001	In daphnodorin A-human chymase complex, daphnodorin A was fixed to the active site via hydrogen bonds with Ala177, Phe29, and Gly199 in human chymase, and it formed hydrogen bonds with Ser182 and Gly180, and this complex was formed stably.	Hydrogen	165-173	chymase 1	Homo sapiens	142-149
11350059-3	2001	In daphnodorin B-human chymase complex, daphnodorin B formed hydrogen bonds with Lys28 and Phe29 in human chymase, but it could not form hydrogen bonds with Gly199, Ala177, and Lys179.	Hydrogen	61-69	chymase 1	Homo sapiens	23-30
11350059-5	2001	For the inhibition of human chymase by daphnodorins, we indicated that it was significant whether daphnodorins formed hydrogen bonds with Ala177 located in the P1 hole, Ser182 located in the active site, Gly180 located in the anion hole, and with Gly199, Phe29, and Lys28 in human chymase.	Hydrogen	118-126	chymase 1	Homo sapiens	28-35
11394288-0	2001	Investigation of water environments in a C18 bonded silica phase using 1H magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy.	Hydrogen	71-73	Bardet-Biedl syndrome 9	Homo sapiens	41-44
11457157-8	2001	These PT processes are attributed to the rearrangement of the hydrogen-bonding network of the protein associated with the transition between the oxidized and reduced state of Cyt-c.	Hydrogen	62-70	cytochrome c, somatic	Homo sapiens	175-180
18968272-4	2001	ATR-FTIR studies were used to determine the nature of the polymer-polynitroaromatic analyte interactions, and confirm the presence of hydrogen-bonding between polymer pendant groups and the nitro functional groups of polynitroaromatic explosive materials.	Hydrogen	134-142	ATR serine/threonine kinase	Homo sapiens	0-3
11394288-1	2001	High resolution 1H magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectra have been obtained on typical C18 bonded silicas used in chromatographic solid-phase extraction separations.	Hydrogen	16-18	Bardet-Biedl syndrome 9	Homo sapiens	117-120
11394020-13	2001	1H decoupled 31P NMR spectra of EYPC + C10 aqueous dispersions have shown that the lipid bilayer transforms into nonbilayer phases at C10:EYPC &gt; 1:1 molar ratios.	Hydrogen	0-2	homeobox C10	Homo sapiens	39-42
11394020-13	2001	1H decoupled 31P NMR spectra of EYPC + C10 aqueous dispersions have shown that the lipid bilayer transforms into nonbilayer phases at C10:EYPC &gt; 1:1 molar ratios.	Hydrogen	0-2	homeobox C10	Homo sapiens	134-137
11370779-2	2001	A beta-hairpin, the smallest beta-sheet motif, consists of two antiparallel hydrogen-bonded beta-strands linked by a loop region.	Hydrogen	76-84	amyloid beta precursor protein	Homo sapiens	0-6
11292354-5	2001	Two of the other hydrogen bonds between the inhibitor and active site of the trypsin and uPA complexes become short in the thrombin counterparts, extending the three-centered short hydrogen-bonding array into a tetrahedral array of atoms (three oxygen and one nitrogen) involved in short hydrogen bonds.	Hydrogen	17-25	plasminogen activator, urokinase	Homo sapiens	89-92
11292354-5	2001	Two of the other hydrogen bonds between the inhibitor and active site of the trypsin and uPA complexes become short in the thrombin counterparts, extending the three-centered short hydrogen-bonding array into a tetrahedral array of atoms (three oxygen and one nitrogen) involved in short hydrogen bonds.	Hydrogen	17-25	coagulation factor II, thrombin	Homo sapiens	123-131
11292354-5	2001	Two of the other hydrogen bonds between the inhibitor and active site of the trypsin and uPA complexes become short in the thrombin counterparts, extending the three-centered short hydrogen-bonding array into a tetrahedral array of atoms (three oxygen and one nitrogen) involved in short hydrogen bonds.	Hydrogen	181-189	plasminogen activator, urokinase	Homo sapiens	89-92
11292354-5	2001	Two of the other hydrogen bonds between the inhibitor and active site of the trypsin and uPA complexes become short in the thrombin counterparts, extending the three-centered short hydrogen-bonding array into a tetrahedral array of atoms (three oxygen and one nitrogen) involved in short hydrogen bonds.	Hydrogen	181-189	coagulation factor II, thrombin	Homo sapiens	123-131
11124966-3	2001	In addition, water-mediated interactions replace the hydrogen bonding interactions between the N(6) of anti-cAMP bound in the N-terminal domains of each subunit and the OH groups of the Thr(127) and Ser(128) residues in the C alpha-helix of wild type CRP.	Hydrogen	53-61	C-reactive protein	Homo sapiens	251-254
11292354-5	2001	Two of the other hydrogen bonds between the inhibitor and active site of the trypsin and uPA complexes become short in the thrombin counterparts, extending the three-centered short hydrogen-bonding array into a tetrahedral array of atoms (three oxygen and one nitrogen) involved in short hydrogen bonds.	Hydrogen	181-189	plasminogen activator, urokinase	Homo sapiens	89-92
11292354-5	2001	Two of the other hydrogen bonds between the inhibitor and active site of the trypsin and uPA complexes become short in the thrombin counterparts, extending the three-centered short hydrogen-bonding array into a tetrahedral array of atoms (three oxygen and one nitrogen) involved in short hydrogen bonds.	Hydrogen	181-189	coagulation factor II, thrombin	Homo sapiens	123-131
11292354-6	2001	In the uPA complexes, the extensive hydrogen-bonding interactions at the active site prevent the inhibitor S1 amidine from forming direct hydrogen bonds with Asp189 because the S1 site is deeper in uPA than in trypsin or thrombin.	Hydrogen	36-44	plasminogen activator, urokinase	Homo sapiens	7-10
11292354-6	2001	In the uPA complexes, the extensive hydrogen-bonding interactions at the active site prevent the inhibitor S1 amidine from forming direct hydrogen bonds with Asp189 because the S1 site is deeper in uPA than in trypsin or thrombin.	Hydrogen	36-44	plasminogen activator, urokinase	Homo sapiens	198-201
11292354-6	2001	In the uPA complexes, the extensive hydrogen-bonding interactions at the active site prevent the inhibitor S1 amidine from forming direct hydrogen bonds with Asp189 because the S1 site is deeper in uPA than in trypsin or thrombin.	Hydrogen	36-44	coagulation factor II, thrombin	Homo sapiens	221-229
11292354-6	2001	In the uPA complexes, the extensive hydrogen-bonding interactions at the active site prevent the inhibitor S1 amidine from forming direct hydrogen bonds with Asp189 because the S1 site is deeper in uPA than in trypsin or thrombin.	Hydrogen	138-146	plasminogen activator, urokinase	Homo sapiens	7-10
11292354-6	2001	In the uPA complexes, the extensive hydrogen-bonding interactions at the active site prevent the inhibitor S1 amidine from forming direct hydrogen bonds with Asp189 because the S1 site is deeper in uPA than in trypsin or thrombin.	Hydrogen	138-146	plasminogen activator, urokinase	Homo sapiens	198-201
11292354-6	2001	In the uPA complexes, the extensive hydrogen-bonding interactions at the active site prevent the inhibitor S1 amidine from forming direct hydrogen bonds with Asp189 because the S1 site is deeper in uPA than in trypsin or thrombin.	Hydrogen	138-146	coagulation factor II, thrombin	Homo sapiens	221-229
11254321-1	2001	A new anionic surfactant (M-LAMS) that is capable of forming intermolecular hydrogen bonds was investigated.	Hydrogen	76-84	laminin subunit beta 2	Homo sapiens	28-32
11349819-2	2001	This model, HINT for Hydropathic INTeractions, is shown to include, in very empirical and approximate terms, all components of biomolecular associations, including hydrogen bonding, Coulombic interactions, hydrophobic interactions, entropy and solvation/desolvation.	Hydrogen	164-172	histidine triad nucleotide binding protein 1	Homo sapiens	12-16
11248216-8	2001	These results indicate that cultures of human keratinocytes and melanocytes established from human skin and melanoma cells express the NHE-1 isoform of the sodium--hydrogen exchanger.	Hydrogen	164-172	solute carrier family 9 member A1	Homo sapiens	135-140
11374583-6	2001	As expected for six-coordinate CoIII complexes, 5 and 6 are diamagnetic in agreement with their 1H and 13C NMR spectra.	Hydrogen	96-98	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	31-36
11465405-5	2001	Initial interactive docking studies with a homology model of human CYP3A4 indicated that BFBFC was likely to be a selective substrate for CYP3A4 with a relatively high binding affinity, due to the presence of several key hydrogen bonds with active site amino acid residues.	Hydrogen	221-229	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-73
11465405-5	2001	Initial interactive docking studies with a homology model of human CYP3A4 indicated that BFBFC was likely to be a selective substrate for CYP3A4 with a relatively high binding affinity, due to the presence of several key hydrogen bonds with active site amino acid residues.	Hydrogen	221-229	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	138-144
11297347-1	2001	The possible influence of thermal motion on 1H chemical shifts is discussed for a small stable protein, the bovine pancreatic Kunitz trypsin inhibitor (BPTI).	Hydrogen	44-46	trophoblast Kunitz domain protein 1	Bos taurus	133-150
11223514-6	2001	Most of the receptor-binding residues identified in FGF1- and FGF2-receptor complexes are buried in the dimer interface, with the beta8-beta9 loop stabilized in a particular conformation by an intramolecular hydrogen-bonding network.	Hydrogen	208-216	fibroblast growth factor 1	Homo sapiens	52-56
11223514-6	2001	Most of the receptor-binding residues identified in FGF1- and FGF2-receptor complexes are buried in the dimer interface, with the beta8-beta9 loop stabilized in a particular conformation by an intramolecular hydrogen-bonding network.	Hydrogen	208-216	fibroblast growth factor 2	Homo sapiens	62-66
11289431-4	2001	The changes in the contrasts of porphyrin centers of Por-2H and Por-Zn/ Por-Ni were explained by facilitated electron tunneling due to hydrogen bond and metal coordination interactions, respectively, between porphyrin centers and the pyridyl group of 4MP on the tip.	Hydrogen	135-143	cytochrome p450 oxidoreductase	Homo sapiens	53-56
11289431-4	2001	The changes in the contrasts of porphyrin centers of Por-2H and Por-Zn/ Por-Ni were explained by facilitated electron tunneling due to hydrogen bond and metal coordination interactions, respectively, between porphyrin centers and the pyridyl group of 4MP on the tip.	Hydrogen	135-143	cytochrome p450 oxidoreductase	Homo sapiens	64-67
11289431-4	2001	The changes in the contrasts of porphyrin centers of Por-2H and Por-Zn/ Por-Ni were explained by facilitated electron tunneling due to hydrogen bond and metal coordination interactions, respectively, between porphyrin centers and the pyridyl group of 4MP on the tip.	Hydrogen	135-143	cytochrome p450 oxidoreductase	Homo sapiens	64-67
11333022-3	2001	The results demonstrate that the overall strength of hydrogen bonding between the 5" splice site, SD4, and the free 5" end of the U1 snRNA correlates with env expression efficiency, as long as env expression is suboptimal, and that a continuous stretch of 14 hydrogen bonds can lead to full env expression, as a result of stabilizing the pre-mRNA.	Hydrogen	53-61	endogenous retrovirus group W member 1, envelope	Homo sapiens	155-158
11333022-3	2001	The results demonstrate that the overall strength of hydrogen bonding between the 5" splice site, SD4, and the free 5" end of the U1 snRNA correlates with env expression efficiency, as long as env expression is suboptimal, and that a continuous stretch of 14 hydrogen bonds can lead to full env expression, as a result of stabilizing the pre-mRNA.	Hydrogen	53-61	endogenous retrovirus group W member 1, envelope	Homo sapiens	193-196
11333022-3	2001	The results demonstrate that the overall strength of hydrogen bonding between the 5" splice site, SD4, and the free 5" end of the U1 snRNA correlates with env expression efficiency, as long as env expression is suboptimal, and that a continuous stretch of 14 hydrogen bonds can lead to full env expression, as a result of stabilizing the pre-mRNA.	Hydrogen	53-61	endogenous retrovirus group W member 1, envelope	Homo sapiens	193-196
11333022-3	2001	The results demonstrate that the overall strength of hydrogen bonding between the 5" splice site, SD4, and the free 5" end of the U1 snRNA correlates with env expression efficiency, as long as env expression is suboptimal, and that a continuous stretch of 14 hydrogen bonds can lead to full env expression, as a result of stabilizing the pre-mRNA.	Hydrogen	259-267	endogenous retrovirus group W member 1, envelope	Homo sapiens	155-158
11225118-1	2001	A superoxochromium(III) ion, CraqOO2+, abstracts the hydrogen atom from the hydroxylic group of a substituted, cationic phenol (ArOH), kCrOO = 1.24 M-1 s-1 in acidic aqueous solution at 25 degrees C. The reaction has a large kinetic isotope effect, kArOH/kArOD approximately 12 and produces ArO., which also reacts with CraqOO2+ in a rapid second step, kArO = 1.26 x 10(4) M-1 s-1.	Hydrogen	53-61	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	128-131
11178915-1	2001	The kinetics of solvent accessibility at the protein-protein interface between thrombin and a fragment of thrombomodulin, TMEGF45, have been monitored by amide hydrogen/deuterium (H/2H) exchange detected by MALDI-TOF mass spectrometry.	Hydrogen	160-168	coagulation factor II, thrombin	Homo sapiens	79-87
11067854-3	2001	Multiple sequence alignment was used to predict His(1089) as the catalytic residue in human ACE C-domain that, by analogy with the prototypical gluzincin, thermolysin, stabilizes the scissile carbonyl bond through a hydrogen bond during transition state binding.	Hydrogen	216-224	angiotensin I converting enzyme	Homo sapiens	92-95
11327820-4	2001	We have examined the role of two lysines, Lys206 and Lys296, that form a hydrogen-bonded pair close to the N-lobe binding site of human Tf and have been proposed to form a pH-sensitive trigger for iron release.	Hydrogen	73-81	transferrin	Homo sapiens	136-138
11195366-4	2001	Variable-temperature 1H NMR spectroscopy shows that a mixture of [ReCl2(PPh3)2(biimH2)](benzoate) and [ReCl2(PPh3)2(biimH2)]Cl is in slow exchange below -50 degrees C in CD2Cl2, indicating that ion pairing is retained in solution.	Hydrogen	21-23	caveolin 1	Homo sapiens	72-76
11162118-1	2001	Fluorescence spectroscopy and 1H/2H-exchange techniques have been applied to characterize the folding of an scFv fragment, derived from the humanized anti-HER2 antibody hu4D5-8.	Hydrogen	30-32	immunglobulin heavy chain variable region	Homo sapiens	108-112
11162118-3	2001	A partially structured intermediate, with 1H/2H-exchange protection significantly less than that of the two isolated domains together, is detectable upon refolding the equilibrium-denatured scFv fragment.	Hydrogen	42-44	immunglobulin heavy chain variable region	Homo sapiens	190-194
11306056-7	2001	Residue Pro47 of the wild type ADH2 enzyme seems to strain the binding of coenzyme, which prevents a close approach between the coenzyme and substrate for efficient hydrogen transfer.	Hydrogen	165-173	alcohol dehydrogenase 4 (class II), pi polypeptide	Mus musculus	31-35
11148219-5	2001	In the crystal structure of the Ly49A/H-2D(d) complex, these residues are involved in hydrogen bonding to Ly49A in one of the two potential Ly49A binding sites on H-2D(d).	Hydrogen	86-94	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	32-37
11148219-5	2001	In the crystal structure of the Ly49A/H-2D(d) complex, these residues are involved in hydrogen bonding to Ly49A in one of the two potential Ly49A binding sites on H-2D(d).	Hydrogen	86-94	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	106-111
11148219-5	2001	In the crystal structure of the Ly49A/H-2D(d) complex, these residues are involved in hydrogen bonding to Ly49A in one of the two potential Ly49A binding sites on H-2D(d).	Hydrogen	86-94	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	106-111
11147777-1	2001	Cross-sectional studies in human subjects have used 1H magnetic resonance spectroscopy (HMRS) to demonstrate that insulin resistance correlates more tightly with the intramyocellular lipid (IMCL) concentration than with any other identified risk factor.	Hydrogen	52-54	insulin	Homo sapiens	114-121
11038349-1	2001	The refolding kinetics of the 140-residue, all beta-sheet, human fibroblast growth factor (hFGF-1) is studied using a variety of biophysical techniques such as stopped-flow fluorescence, stopped-flow circular dichroism, and quenched-flow hydrogen exchange in conjunction with multidimensional NMR spectroscopy.	Hydrogen	238-246	fibroblast growth factor 1	Homo sapiens	91-97
11038349-4	2001	Results of the quenched-flow hydrogen exchange experiments reveal that the hydrogen bonds linking the N- and C-terminal ends are the first to form during the refolding of hFGF-1.	Hydrogen	29-37	fibroblast growth factor 1	Homo sapiens	171-177
11038349-4	2001	Results of the quenched-flow hydrogen exchange experiments reveal that the hydrogen bonds linking the N- and C-terminal ends are the first to form during the refolding of hFGF-1.	Hydrogen	75-83	fibroblast growth factor 1	Homo sapiens	171-177
11249123-6	2001	The most potent compound 1h (Ki = 0.0506 microM) is superior in potency to the parent peptidic inhibitor Val-Pro-Phe-CF3 and has good selectivity for chymase over other proteases.	Hydrogen	25-27	chymase 1	Homo sapiens	150-157
11210867-5	2001	The purpose of this study was to investigate the profile of cytokines IFNgamma and IL-4 that occurs in vivo in anti-H2-treated patients with allergic rhinitis (AR).	Hydrogen	116-118	interferon gamma	Homo sapiens	70-78
11210867-5	2001	The purpose of this study was to investigate the profile of cytokines IFNgamma and IL-4 that occurs in vivo in anti-H2-treated patients with allergic rhinitis (AR).	Hydrogen	116-118	interleukin 4	Homo sapiens	83-87
11210867-7	2001	RESULTS: A comparison of the serum cytokine values recorded before and after anti-H2 treatment showed a significant increase in INF-gamma serum level (P = .003) and a decrease in IL-4 (P = .016).	Hydrogen	82-84	interleukin 4	Homo sapiens	179-183
11210867-9	2001	CONCLUSION: H2 antagonists probably induce their effects by enhancing the amount of IFN-gamma and by reducing IL-4 cytokines, which, respectively, induce a decrease and an increase in the IgE synthesis.	Hydrogen	12-14	interferon gamma	Homo sapiens	84-93
11210867-9	2001	CONCLUSION: H2 antagonists probably induce their effects by enhancing the amount of IFN-gamma and by reducing IL-4 cytokines, which, respectively, induce a decrease and an increase in the IgE synthesis.	Hydrogen	12-14	interleukin 4	Homo sapiens	110-114
11210867-9	2001	CONCLUSION: H2 antagonists probably induce their effects by enhancing the amount of IFN-gamma and by reducing IL-4 cytokines, which, respectively, induce a decrease and an increase in the IgE synthesis.	Hydrogen	12-14	immunoglobulin heavy constant epsilon	Homo sapiens	188-191
11180344-0	2001	6-Aminofulvene-1-aldimine: A Model Molecule for the Study of Intramolecular Hydrogen Bonds We are indebted to DGES/MEC (PB96-0001-C03) and Comunidad de Madrid (grant no.	Hydrogen	76-84	C-C motif chemokine ligand 28	Homo sapiens	115-118
11195366-4	2001	Variable-temperature 1H NMR spectroscopy shows that a mixture of [ReCl2(PPh3)2(biimH2)](benzoate) and [ReCl2(PPh3)2(biimH2)]Cl is in slow exchange below -50 degrees C in CD2Cl2, indicating that ion pairing is retained in solution.	Hydrogen	21-23	caveolin 1	Homo sapiens	109-113
11200534-0	2000	1H, 15N, and 13C NMR resonance assignments for the Eps15 homology domain of Reps1.	Hydrogen	0-2	epidermal growth factor receptor pathway substrate 15	Homo sapiens	51-56
11214651-0	2001	1H MR spectroscopy evidence for the varied nature of asymptomatic focal brain lesions in neurofibromatosis type 1.	Hydrogen	0-2	neurofibromin 1	Homo sapiens	89-113
11214651-1	2001	We present the MRI and 1H MR spectroscopy findings in six patients with neurofibromatosis type 1 (NF1) and asymptomatic focal brain lesions.	Hydrogen	23-25	neurofibromin 1	Homo sapiens	72-96
11162427-1	2000	The single tryptophan at position 121 of human interleukin-2 (IL-2) can form an NH-pi hydrogen bond with Phe 117 involving the indole nitrogen and the benzene aromatic ring.	Hydrogen	86-94	interleukin 2	Homo sapiens	47-60
11162427-1	2000	The single tryptophan at position 121 of human interleukin-2 (IL-2) can form an NH-pi hydrogen bond with Phe 117 involving the indole nitrogen and the benzene aromatic ring.	Hydrogen	86-94	interleukin 2	Homo sapiens	62-66
11123949-0	2000	NMR evidence for a short, strong hydrogen bond at the active site of a cholinesterase.	Hydrogen	33-41	butyrylcholinesterase	Equus caballus	71-85
10960471-15	2000	), indicate that the most likely positioning of fMLF in the binding pocket of FPR is approximately parallel to the fifth transmembrane helix with the formamide group of fMLF hydrogen-bonded to both Asp-106 and Arg-201, the leucine side chain pointing toward the second transmembrane region, and the COOH-terminal carboxyl group of fMLF ion-paired with Arg-205.	Hydrogen	174-182	formyl peptide receptor 1	Homo sapiens	78-81
11233675-1	2000	This study reports a comparison of Fluorine-18 deoxyglucose positron emission tomography (FDG-PET) and O-15 water (H2(15)O) PET with regard to lateralization of the seizure focus in patients with complex partial epilepsy.	Hydrogen	115-117	immunoglobulin kappa variable 2-36 (pseudogene)	Homo sapiens	103-107
11384861-10	2001	An X-ray crystal structure of the GC-1-TRbeta LBD complex suggests that the oxoacetate does participate in a network of hydrogen bonding in the TR LBD polar pocket.	Hydrogen	120-128	apoptosis antagonizing transcription factor	Mus musculus	39-45
11262979-5	2001	Hydrogen exchange rate constants for CspA fibrils were found to vary less than 3-fold from a mean value of 5 x 10(-5) min-1.	Hydrogen	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	118-123
11266599-5	2001	This TRIS molecule has hydrogen bonds to active site residues corresponding to the residues that interact with the small phenolic substrate ferulic acid in the horseradish peroxidase C (HRPC):ferulic acid complex.	Hydrogen	23-31	peroxidase	Glycine max	172-182
11087832-1	2000	We describe here experiments designed to characterize the secondary structure of amyloid fibrils of the Alzheimer"s amyloid plaque peptide Abeta, using hydrogen-deuterium exchange measurements evaluated by mass spectrometry.	Hydrogen	152-160	amyloid beta precursor protein	Homo sapiens	139-144
11200536-0	2000	1H, 13C and 15N resonance assignments of the SNT PTB domain in complex with FGFR1 peptide.	Hydrogen	0-2	fibroblast growth factor receptor 1	Homo sapiens	76-81
11097184-7	2000	Aligning the TXAS sequence with the structurally known P450s, we proposed that in TXAS the A-ring propionate of the heme is hydrogen bonded to Asn-110, Arg-413, and Arg-478, whereas D-ring propionate is hydrogen bonded to Trp-133 and Arg-137.	Hydrogen	203-211	thromboxane A synthase 1	Homo sapiens	82-86
11153935-6	2000	The (GRF) value varies with the connectivity ability of a functional group for extended conjugation, substitution, etc., but is most influenced by hydrogen bonding (H-bonding) with the stationary liquid phase.	Hydrogen	147-155	growth hormone releasing hormone	Homo sapiens	5-8
11097184-7	2000	Aligning the TXAS sequence with the structurally known P450s, we proposed that in TXAS the A-ring propionate of the heme is hydrogen bonded to Asn-110, Arg-413, and Arg-478, whereas D-ring propionate is hydrogen bonded to Trp-133 and Arg-137.	Hydrogen	124-132	thromboxane A synthase 1	Homo sapiens	13-17
11097184-7	2000	Aligning the TXAS sequence with the structurally known P450s, we proposed that in TXAS the A-ring propionate of the heme is hydrogen bonded to Asn-110, Arg-413, and Arg-478, whereas D-ring propionate is hydrogen bonded to Trp-133 and Arg-137.	Hydrogen	124-132	thromboxane A synthase 1	Homo sapiens	82-86
10995243-6	2000	In each structure, the imino and amino protons of the anti G are hydrogen bonded to the O6 and N7 acceptors of the syn G, respectively.	Hydrogen	65-73	synergin gamma	Homo sapiens	115-120
11152127-6	2000	Surprisingly, several highly conserved side-chain to main-chain hydrogen bonds were observed in the functionally crucial RT-Src loop between residues with little direct involvement in peptide binding.	Hydrogen	64-72	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	124-127
11015223-13	2000	At alkaline pH, PGHS-1 is converted to a second CO binding conformation (nu(Fe)(-)(CO): 496 cm(-1)) where disruption of the hydrogen bonding interactions to the proximal histidine may occur.	Hydrogen	124-132	prostaglandin-endoperoxide synthase 1	Homo sapiens	16-22
11069215-5	2000	H2 antagonists, proton pump inhibitors and prokinetic agents undergo metabolism by the cytochrome P450 (CYP) system present in the liver and gastrointestinal tract.	Hydrogen	0-2	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	87-102
11069215-5	2000	H2 antagonists, proton pump inhibitors and prokinetic agents undergo metabolism by the cytochrome P450 (CYP) system present in the liver and gastrointestinal tract.	Hydrogen	0-2	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	104-107
11106159-1	2000	A direct conflict between the stabilization free energy parameters of cytochrome c determined by optical methods and by hydrogen exchange (HX) is quantitatively explained when the partially folded intermediates seen by HX are taken into account.	Hydrogen	120-128	cytochrome c, somatic	Homo sapiens	70-82
11121731-2	2000	In addition, the hydrogen bond donor patterns (type I and type II) relevant for substrate recognition by P-glycoprotein were determined from the energy-minimized three-dimensional structure of these compounds.	Hydrogen	17-25	ATP binding cassette subfamily B member 1	Homo sapiens	105-119
11121731-5	2000	If two substrates are applied simultaneously to P-glycoprotein the compound with the higher potential to form hydrogen bonds generally acts as an inhibitor.	Hydrogen	110-118	ATP binding cassette subfamily B member 1	Homo sapiens	48-62
11121731-6	2000	We conclude that partitioning into the lipid membrane is the rate-limiting step for the interaction of a substrate with P-glycoprotein and that dissociation of the P-glycoprotein-substrate complex is determined by the number and strength of the hydrogen bonds formed between the substrate and the transporter.	Hydrogen	245-253	ATP binding cassette subfamily B member 1	Homo sapiens	164-178
11085653-1	2000	Solution 1H NMR spectroscopy was used to investigate the heme active-site structure and dynamics of rotation about the Fe-His bond of centrosymmetric etioheme-I reconstituted into sperm whale and horse myoglobin (Mb).	Hydrogen	9-11	myoglobin	Equus caballus	202-211
11101222-0	2000	Assignment of 1H(N), 15N, 13C(alpha), 13CO and 13C(beta) resonances in a 67 kDa p53 dimer using 4D-TROSY NMR spectroscopy.	Hydrogen	14-16	tumor protein p53	Homo sapiens	80-83
10995243-7	2000	An additional hydrogen-bond connects the syn G amino group to the 5" nonbridging pro-R(p) phosphate oxygen.	Hydrogen	14-22	synergin gamma	Homo sapiens	41-46
11032405-4	2000	We have solved the structure of an N-terminal peptide of Cx26 (MDWGTLQSILGGVNK) using 1H 2D NMR.	Hydrogen	86-88	gap junction protein beta 2	Homo sapiens	57-61
11011072-0	2000	Role of phospholipase A(2) on the variations of the choline signal intensity observed by 1H magnetic resonance spectroscopy in brain diseases.	Hydrogen	89-91	phospholipase A2 group IB	Homo sapiens	8-25
10970744-10	2000	Mouse ADH2 is known as an inefficient ADH with a slow hydrogen-transfer step.	Hydrogen	54-62	alcohol dehydrogenase 4 (class II), pi polypeptide	Mus musculus	6-10
10987422-1	2000	The intestinal permeability of benzamidine analogue thrombin inhibitor is correlated with molecular volume, lipophilicity (calculated log P and IAM column capacity factor), hydrogen bond acidity/basicity and dipolarity.	Hydrogen	173-181	coagulation factor II, thrombin	Homo sapiens	52-60
11198860-4	2000	Comparison with the new structurally characterized compound (BIK)WO2Cl2 (4) (BIK = bis(1-methylimidazol-2-yl)ketone), which has W-N bonds of about 2.30 A, confirms the unusual length of the W-N bond in 3, probably caused by repulsion between one of the oxo ligands and the peri-hydrogen atom (H6) of DMA.	Hydrogen	278-286	BCL2 interacting killer	Homo sapiens	61-64
11011072-1	2000	Phospholipase A(2) catalyzes the hydrolysis of membrane glycerophospholipids leading to the production of metabolites observable by both 1H and 31P magnetic resonance spectroscopy.	Hydrogen	137-139	phospholipase A2 group IB	Homo sapiens	0-18
11011072-6	2000	In this review, the relationships between the results of 1H and 31P magnetic resonance spectroscopy and the phospholipase A(2) assays are analyzed.	Hydrogen	57-59	phospholipase A2 group IB	Homo sapiens	108-126
11045613-1	2000	The rate and extent of hydrogen/deuterium (H/D) exchange into purine nucleoside phosphorylase (PNP) was monitored by electrospray ionization mass spectrometry (ESI-MS) to probe protein conformational and dynamic changes induced by a substrate analogue, products, and a transition state analogue.	Hydrogen	23-31	purine nucleoside phosphorylase	Homo sapiens	62-93
10966822-0	2000	Formation of hydrogen bonds precedes the rate-limiting formation of persistent structure in the folding of ACBP.	Hydrogen	13-21	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	107-111
10966822-1	2000	A burst phase in the early folding of the four-helix two-state folder protein acyl-coenzyme A binding protein (ACBP) has been detected using quenched-flow in combination with site-specific NMR-detected hydrogen exchange.	Hydrogen	202-210	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	78-109
10966822-1	2000	A burst phase in the early folding of the four-helix two-state folder protein acyl-coenzyme A binding protein (ACBP) has been detected using quenched-flow in combination with site-specific NMR-detected hydrogen exchange.	Hydrogen	202-210	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	111-115
11045613-1	2000	The rate and extent of hydrogen/deuterium (H/D) exchange into purine nucleoside phosphorylase (PNP) was monitored by electrospray ionization mass spectrometry (ESI-MS) to probe protein conformational and dynamic changes induced by a substrate analogue, products, and a transition state analogue.	Hydrogen	23-31	purine nucleoside phosphorylase	Homo sapiens	95-98
10993359-4	2000	Both the alpha,alpha- and alpha,beta-isomers of the bromomethyl porphyrins were converted to their aminomethyl derivatives, H2(alpha,alpha-AP) and H2(alpha,beta-AP), through the corresponding imidoporphyrin intermediates, H2(alpha,alpha-IP) and H2(alpha,beta-IP), by the Gabriel synthesis.	Hydrogen	124-126	tubulin alpha 4a	Homo sapiens	245-261
10993359-4	2000	Both the alpha,alpha- and alpha,beta-isomers of the bromomethyl porphyrins were converted to their aminomethyl derivatives, H2(alpha,alpha-AP) and H2(alpha,beta-AP), through the corresponding imidoporphyrin intermediates, H2(alpha,alpha-IP) and H2(alpha,beta-IP), by the Gabriel synthesis.	Hydrogen	147-149	tubulin alpha 4a	Homo sapiens	245-261
10896318-7	2000	Finally, a charged glutamate residue generates strong hydrogen bonding and electrostatic interactions with the hydroxyl groups at C10 and C15.	Hydrogen	54-62	homeobox C10	Homo sapiens	130-133
10987367-10	2000	Results from molecular modeling suggest that a strong reorganization of the hydrogen bonds in the active site of thrombin may result in the proteolytic stability found in this inhibitor series.	Hydrogen	76-84	coagulation factor II, thrombin	Homo sapiens	113-121
10887057-2	2000	The renal mechanism(s) responsible for the potent stimulation of renal hydrogen ion secretion by GH remain to be elucidated.	Hydrogen	71-79	growth hormone 1	Homo sapiens	97-99
10959635-0	2000	Letter to the editor: sequence-specific 1H, 13C and 15N chemical shift backbone NMR assignment and secondary structure of the Arabidopsis thaliana PIN1At protein.	Hydrogen	40-42	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Arabidopsis thaliana	147-153
10959965-11	2000	The rate of electron transfer at sp2 carbon electrodes is known to be mediated by surface carbonyl functionalities; however, this inner-sphere, catalytic pathway is absent on diamond due to the hydrogen termination.	Hydrogen	194-202	Sp2 transcription factor	Homo sapiens	33-36
10920035-6	2000	Hydrogen exchange measurements show that in solution these higher oligomers are in rapid equilibrium with monomeric insulin.	Hydrogen	0-8	insulin	Homo sapiens	116-123
10913275-11	2000	Tyr299, Tyr300 in CS2 modified by N-bromoacetyl-L-arginine, is hydrogen bonded to Glu146 (Glu147 in CS2) in this structure and well-positioned for reaction with the affinity label.	Hydrogen	63-71	chorionic somatomammotropin hormone 2	Homo sapiens	18-21
10913275-11	2000	Tyr299, Tyr300 in CS2 modified by N-bromoacetyl-L-arginine, is hydrogen bonded to Glu146 (Glu147 in CS2) in this structure and well-positioned for reaction with the affinity label.	Hydrogen	63-71	chorionic somatomammotropin hormone 2	Homo sapiens	100-103
10861225-6	2000	In addition, the serine mutant introduced a hydrogen-bonding potential at position 76 similar to that observed in human renin.	Hydrogen	44-52	renin	Homo sapiens	120-125
10913675-1	2000	We have examined the sequence of the cDNA encoding the sodium/hydrogen exchanger isoform 1 (NHE1), from 23 bases upstream of the start codon to 28 bases downstream of the stop codon.	Hydrogen	62-70	solute carrier family 9 member A1	Homo sapiens	92-96
10884290-6	2000	This reduction corresponds to a decrease in free energy of binding of approximately 600 cal/mol, consistent with the elimination of a hydrogen-bonded ion pair (salt bridge) between a lysine on apoE and an acidic residue on the LDLR.	Hydrogen	134-142	apolipoprotein E	Homo sapiens	193-197
10926216-0	2000	Evidence for a dinuclear mechanism in alkyne hydrogenations catalyzed by pyrazolate-bridged diiridium complexes The products obtained from the sequential reaction of [Ir2(mu-H)(mu-Pz)2H3(NCCH3)(PiPr3)2] (1) with diphenylacetylene and their subsequent reactions with hydrogen have been investigated in order to deduce the mechanisms operating in the hydrogenation reactions catalyzed by 1.	Hydrogen	45-53	familial progressive hyperpigmentation 1	Homo sapiens	171-175
10848604-4	2000	This interaction was disrupted by mutations designed to disrupt hydrophobic interactions (hpm mutation) or hydrogen bonding (Q241A mutation) based on the cyclin A-p27 crystal structure.	Hydrogen	107-115	zinc ribbon domain containing 2	Homo sapiens	163-166
10933493-4	2000	The three-dimensional structure of LB(1-2) has now been solved using two-dimensional 1H NMR spectroscopy and restrained molecular dynamics calculations.	Hydrogen	85-87	cytoskeleton associated protein 2	Homo sapiens	35-41
10941006-0	2000	Hydrogen-Bonded Dioxygen Adduct of an Iron Porphyrin with an Alkanethiolate Ligand: An Elaborate Model of Cytochrome P450 This research was supported by the Ministry of Education, Science, and Culture, Japan (Grant-in Aids #08CE2005, 09235225, and 11228207 to Y.N.)	Hydrogen	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	106-121
10873856-10	2000	The contacts between GPb and CP320626 comprise six hydrogen bonds and extensive van der Waals interactions that create a tight binding site in the T-state conformation of GPb.	Hydrogen	51-59	glycophorin B (MNS blood group)	Homo sapiens	21-24
10873856-10	2000	The contacts between GPb and CP320626 comprise six hydrogen bonds and extensive van der Waals interactions that create a tight binding site in the T-state conformation of GPb.	Hydrogen	51-59	glycophorin B (MNS blood group)	Homo sapiens	171-174
10845918-3	2000	Subsets of Ly-49A and Ly-49G2 NK share specificity for the same MHC class 1 ligand, D(d), binding of which results in an inhibitory signal to the NK cell but allows them to lyse H2(b) targets in vitro.	Hydrogen	178-180	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	11-17
10845918-6	2000	However, Ly-49A depletion did partially abrogate the ability of B10.BR (H2(k)) mice to reject H2(b) allografts.	Hydrogen	72-74	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	9-15
10841759-3	2000	The results show that individual (AAT)(6) and (ATT)(6) strands exist principally as monomeric non-hydrogen-bonded structures.	Hydrogen	98-106	serpin family A member 1	Homo sapiens	34-37
10921781-0	2000	Sequence-specific 1H, 13C, and 15N assignments of the MAR-binding domain of chicken MeCP2/ARBP.	Hydrogen	18-20	attachment region binding protein	Gallus gallus	90-94
10860725-7	2000	The 2" hydroxyl group of g15 is hydrogen bonded to O2P and O5" of g17, skipping the bulged adenine a16 and stabilizing the sugar-phosphate backbone of the hybrid.	Hydrogen	32-40	RNA binding motif protein 5	Homo sapiens	25-28
10727931-9	2000	Monitoring complex formation between Hsp25 and dithiothreitol-reduced alpha-lactalbumin by 1H NMR spectroscopy indicates that the C-terminal extension of Hsp25 retains its flexibility during this interaction.	Hydrogen	91-93	lactalbumin, alpha	Mus musculus	70-87
10805774-4	2000	Taking into account the trypsin-like arginine specificity of uPA, (4-aminomethyl)phenylguanidine was selected as a potential P1 residue and iterative derivatization of its amino group with various hydrophobic residues, and structure-activity relationship-based optimization of the spacer in terms of hydrogen bond acceptor/donor properties led to N-(1-adamantyl)-N"-(4-guanidinobenzyl)urea as a highly selective nonpeptidic uPA inhibitor.	Hydrogen	300-308	plasminogen activator, urokinase	Homo sapiens	61-64
10805774-5	2000	The x-ray crystal structure of the uPA B-chain complexed with this inhibitor revealed a surprising binding mode consisting of the expected insertion of the phenylguanidine moiety into the S1 pocket, but with the adamantyl residue protruding toward the hydrophobic S1" enzyme subsite, thus exposing the ureido group to hydrogen-bonding interactions.	Hydrogen	318-326	plasminogen activator, urokinase	Homo sapiens	35-38
10909867-1	2000	Cisproline(i - 1)-aromatic(i) interactions have been detected in several short peptides in aqueous solution by analysis of anomalous chemical shifts measured by 1H-NMR spectroscopy.	Hydrogen	161-163	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	0-16
10909871-0	2000	Sequence-specific 1H, 13C, and 15N assignment of the human melanoma inhibitory activity (MIA) protein.	Hydrogen	18-20	MIA SH3 domain containing	Homo sapiens	59-93
10909873-0	2000	Sequence-specific 1H, 15N, and 13C assignment of the N-terminal domain of the human oncoprotein MDM2 that binds to p53.	Hydrogen	18-20	tumor protein p53	Homo sapiens	115-118
12526562-2	2000	The coordination or ion pairing of the hydrogen-bonded anions H(CF3CO2)2- and H(CH3SO3)2- to NEt4+, Li+, Cu+, and/or Cu2+ was investigated.	Hydrogen	39-47	tetraspanin 5	Homo sapiens	93-97
10779411-7	2000	One selectivity determinant of the benzo[b]thiophene-2-carboxamidines for uPA involves a hydrogen bond at the S1 site to Ogamma(Ser190) that is absent in the Ala190 proteases, tPA, thrombin and factor Xa.	Hydrogen	89-97	plasminogen activator, urokinase	Homo sapiens	74-77
10819962-0	2000	1H NMR structural characterization of a nonmitogenic, vasodilatory, ischemia-protector and neuromodulatory acidic fibroblast growth factor.	Hydrogen	0-2	fibroblast growth factor 1	Homo sapiens	107-138
10698770-1	2000	It has recently been noted that a diversity of hyperthermophilic microorganisms have the ability to reduce Fe(III) with hydrogen as the electron donor, but the reduction of Fe(III) or other metals by these organisms has not been previously examined in detail.	Hydrogen	120-128	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	110-113
11017284-0	2000	Anomalous atomic hydrogen shock pattern in a supersonic plasma Jet A two-photon laser-induced fluorescence study on the transport of ground-state atomic hydrogen in a supersonic plasma jet, generated from an Ar-H (2) mixture, reveals an unexpected shock pattern.	Hydrogen	153-161	F-box and leucine rich repeat protein 15	Homo sapiens	185-188
11017284-0	2000	Anomalous atomic hydrogen shock pattern in a supersonic plasma Jet A two-photon laser-induced fluorescence study on the transport of ground-state atomic hydrogen in a supersonic plasma jet, generated from an Ar-H (2) mixture, reveals an unexpected shock pattern.	Hydrogen	211-216	F-box and leucine rich repeat protein 15	Homo sapiens	185-188
12953497-4	2000	All of which can be explained by the following mechanism: (1) Insertion of Ni+ into bonds of alcohols; (2)Following each insertion, a beta-hydrogen shift onto Ni+ to produce intermediate; (3) Dessociation of each intermediate by loss of neutral molecular to give product ion.	Hydrogen	139-147	amyloid beta precursor protein	Homo sapiens	132-138
10737748-11	2000	Replacement of a hydrogen atom of the 4-NH(2) with an acyl group, or replacement of the whole 4-NH(2) with a 4-oxo moiety, shifted the binding activity toward the A(3) AR.	Hydrogen	17-25	adenosine A3 receptor	Homo sapiens	163-170
10713531-8	2000	Since there are fewer hydrogen bonds to haem C17 propionate O atoms in ATP N than in HRP C, it is suggested that ATP N will lose haem more easily than HRP C. Unlike almost all other class III plant peroxidases, ATP N has a free cysteine residue at a similar position to the suggested secondary substrate-binding site in lignin peroxidase.	Hydrogen	22-30	peroxidase	Arabidopsis thaliana	198-208
10698770-8	2000	In addition to using hydrogen as an electron donor for Fe(III) reduction, P. islandicum grew via Fe(III) reduction in media in which peptone and yeast extract served as potential electron donors.	Hydrogen	21-29	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	58-61
10698770-4	2000	Poorly crystalline Fe(III) oxide could also serve as the electron acceptor for growth on hydrogen.	Hydrogen	89-97	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	22-25
10698770-5	2000	The stoichiometry of hydrogen uptake and Fe(III) oxide reduction was consistent with the oxidation of 1 mol of hydrogen resulting in the reduction of 2 mol of Fe(III).	Hydrogen	21-29	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	162-165
10698770-5	2000	The stoichiometry of hydrogen uptake and Fe(III) oxide reduction was consistent with the oxidation of 1 mol of hydrogen resulting in the reduction of 2 mol of Fe(III).	Hydrogen	111-119	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	44-47
10698770-5	2000	The stoichiometry of hydrogen uptake and Fe(III) oxide reduction was consistent with the oxidation of 1 mol of hydrogen resulting in the reduction of 2 mol of Fe(III).	Hydrogen	111-119	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	162-165
10739114-10	2000	An analysis of the putative transmembrane alpha-helices of MRP1 and P-gp reveals that the amino acid residues with hydrogen-bond donor side chains are arranged preferentially on one side of the helix and amino acid residues with inert (non-hydrogen-bonding) side chains on the other side.	Hydrogen	115-123	ATP binding cassette subfamily C member 1	Homo sapiens	59-63
10739114-10	2000	An analysis of the putative transmembrane alpha-helices of MRP1 and P-gp reveals that the amino acid residues with hydrogen-bond donor side chains are arranged preferentially on one side of the helix and amino acid residues with inert (non-hydrogen-bonding) side chains on the other side.	Hydrogen	240-248	ATP binding cassette subfamily C member 1	Homo sapiens	59-63
10739114-11	2000	In the case of MRP1, the hydrogen-bonding face also contains several cationic residues whereas, in the case of P-gp, it contains clusters of amino acid residues with beta-electron systems.	Hydrogen	25-33	ATP binding cassette subfamily C member 1	Homo sapiens	15-19
10739114-12	2000	CONCLUSIONS: We propose that P-gp and MRP1 recognize type I or type II units in chemical compounds having diverse structures, and that these transporters bind their substrates via hydrogen bond formation.	Hydrogen	180-188	ATP binding cassette subfamily C member 1	Homo sapiens	38-42
10671506-0	2000	Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2.	Hydrogen	21-29	prostaglandin-endoperoxide synthase 2	Homo sapiens	111-127
10805138-0	2000	Assignment of the 1H, 13C and 15N resonances of the C-terminal EF-hands of alpha-actinin in a 14 kDa complex with Z-repeat 7 of titin.	Hydrogen	18-20	actinin alpha 1	Homo sapiens	75-88
10860861-1	2000	The ubiquitous form of the sodium-hydrogen exchanger, NHE1, is devoted to the regulation of intracellular pH and cell volume.	Hydrogen	34-42	solute carrier family 9 member A1	Homo sapiens	54-58
10671506-7	2000	Remarkably, aspirin-treated COX-2 formed 15R-HETE with removal of the pro-S hydrogen at C-13 (3-9% retention of pro-S tritium label), the same stereoselectivity as in the formation of prostaglandins by native cyclooxygenase.	Hydrogen	76-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
10669786-1	2000	The last three C-terminal residues (129-131) of intestinal fatty acid-binding protein (IFABP) participate in four main-chain hydrogen bonds and two electrostatic interactions to sequentially distant backbone and side-chain atoms.	Hydrogen	125-133	fatty acid binding protein 2	Homo sapiens	87-92
10684598-3	2000	Possible explanations for the release of iron from transferrin at low pH include protonation of a histidine ligand and the existence of a pH-sensitive "trigger" involving a hydrogen-bonded pair of lysines in the N-lobe of transferrin.	Hydrogen	173-181	transferrin	Homo sapiens	51-62
11263244-6	2000	The N-terminal residues (especially Met1 and Gln4) of human CCR5 contacted with CD4 residues, mainly with one span (56-59) of CD4 in electrostatic interaction and hydrogen-bonds.	Hydrogen	163-171	CD4 molecule	Homo sapiens	80-83
10938824-6	2000	Plants producing both CDH and BADH generally accumulated higher amounts of glycine betaine than plants producing CDH alone, as determined by 1H NMR analysis.	Hydrogen	141-143	betaine aldehyde dehydrogenase, chloroplastic-like	Nicotiana tabacum	30-34
10633045-4	2000	In each case, the nitrogen at position-1 of the quinazoline accepted a hydrogen bond from a backbone NH (CDK2, Leu-83; p38, Met-109) of the domain connector strand, and aromatic hydrogen atoms at C2 and C8 interacted with backbone carbonyl oxygen atoms of the peptide strand.	Hydrogen	71-79	mitogen-activated protein kinase 14	Homo sapiens	119-122
10633045-4	2000	In each case, the nitrogen at position-1 of the quinazoline accepted a hydrogen bond from a backbone NH (CDK2, Leu-83; p38, Met-109) of the domain connector strand, and aromatic hydrogen atoms at C2 and C8 interacted with backbone carbonyl oxygen atoms of the peptide strand.	Hydrogen	178-186	mitogen-activated protein kinase 14	Homo sapiens	119-122
11263244-6	2000	The N-terminal residues (especially Met1 and Gln4) of human CCR5 contacted with CD4 residues, mainly with one span (56-59) of CD4 in electrostatic interaction and hydrogen-bonds.	Hydrogen	163-171	CD4 molecule	Homo sapiens	126-129
10838019-6	2000	Properties associated with the size of the molecular surface, polarizability and hydrogen bonding had the largest impact on the P-glycoprotein-associated ATPase activity.	Hydrogen	81-89	ATP binding cassette subfamily B member 1	Homo sapiens	128-142
10601869-0	2000	Assignment of heme methyl 1H-NMR resonances of high-spin and low-spin ferric complexes of cytochrome p450cam using one-dimensional and two-dimensional paramagnetic signals enhancement (PASE) magnetization transfer experiments.	Hydrogen	26-28	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	90-105
11291029-0	2000	Tracking lysozyme unfolding during salt-induced precipitation with hydrogen exchange and mass spectrometry.	Hydrogen	67-75	lysozyme	Homo sapiens	9-17
11291029-1	2000	We utilized electrospray ionization mass spectrometry (ESI-MS) and hydrogen-deuterium exchange (HX) to detect unfolding of hen egg white lysozyme during salt-induced precipitation.	Hydrogen	67-75	lysozyme	Homo sapiens	137-145
11325045-2	2000	This study examines the N-terminal domain 1 of CD2 (CD2-1) at different pHs, and in 2,2,2-trifluoroethanol (TFE), using nears- and far-UV circular dichroism (CD), fluorescence, and 1H nuclear magnetic resonance to elucidate factors contributing to the Ig beta-structure.	Hydrogen	181-183	complement C3d receptor 2	Homo sapiens	47-50
11325045-2	2000	This study examines the N-terminal domain 1 of CD2 (CD2-1) at different pHs, and in 2,2,2-trifluoroethanol (TFE), using nears- and far-UV circular dichroism (CD), fluorescence, and 1H nuclear magnetic resonance to elucidate factors contributing to the Ig beta-structure.	Hydrogen	181-183	complement C3d receptor 2	Homo sapiens	52-57
10601869-1	2000	An 1H-NMR study of ferric cytochrome P450cam in different paramagnetic states was performed.	Hydrogen	3-5	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-41
10949120-1	2000	New amide derivatives of 1-(m-chlorophenyl)piperazine, the 5-HT2A antagonists 3-6, with moderate in vitro and in vivo activity were obtained by enlargement of the indolin-2(1H)-one core with 3-arylidene substituents.	Hydrogen	173-175	5-hydroxytryptamine receptor 2A	Homo sapiens	59-65
10944848-4	2000	The results show that the K453E mutation is located at the dimer interface of the PPCA and reduces the hydrogen bond formation in the dimer.	Hydrogen	103-111	cathepsin A	Homo sapiens	82-86
10718615-0	2000	Sequence-specific 1H, 15N and 13C resonance assignments for the third EH domain of Eps15.	Hydrogen	18-20	epidermal growth factor receptor pathway substrate 15	Homo sapiens	83-88
10902168-0	2000	Flexibility and critical hydrogen bonds in cytochrome c.	Hydrogen	25-33	cytochrome c, somatic	Homo sapiens	43-55
10632045-3	1999	We have probed the possible bioactive conformations of thrombin receptor-activating peptides (TRAPs) by systematic introduction of certain conformational perturbations, involving alpha-methyl, ester psi(COO), and reduced-amide psi(CH2N) scans, into the minimum-essential agonist sequence (SFLLR) to probe the importance of the backbone conformation and amide NH hydrogen bonding.	Hydrogen	362-370	coagulation factor II, thrombin	Homo sapiens	55-63
11256749-6	2000	The allotype specificity of KIR2DL2 for HLA-Cw3 is the result of a single hydrogen bond from Lys44 of the KIR to Asn80 of HLA-C as all other HLA-C residues that contact KIR are conserved.	Hydrogen	74-82	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2	Homo sapiens	28-31
11256749-6	2000	The allotype specificity of KIR2DL2 for HLA-Cw3 is the result of a single hydrogen bond from Lys44 of the KIR to Asn80 of HLA-C as all other HLA-C residues that contact KIR are conserved.	Hydrogen	74-82	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2	Homo sapiens	106-109
10659948-9	2000	Consequently, it was found that the CYP2E1 active site exhibits complementarity with the structural characteristics of known substrates and inhibitors of this enzyme, including their relatively low molecular weights and disposition of hydrogen bond-forming groups.	Hydrogen	235-243	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	36-42
10600384-8	1999	In contrast to serine 29 of profilin I, tyrosine 29 in profilin II is capable of forming an additional stacking interaction and a hydrogen bond with poly-L-proline which may account for the increased affinity of the second isoform for proline-rich peptides.	Hydrogen	130-138	profilin 1	Homo sapiens	28-51
10631978-1	1999	Sequential 1H-NMR assignments of mouse [Cd7]-metallothionein-1 (MT1) have been carried out by standard homonuclear NMR methods and the use of an accordion-heteronuclear multiple quantum correlation (HMQC) experiment for establishing the metal, 113Cd2+, to cysteine connectivities.	Hydrogen	11-13	metallothionein 1	Mus musculus	64-67
10593884-0	1999	Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction.	Hydrogen	103-111	glutaredoxin 2	Homo sapiens	73-87
10593884-4	1999	In this report glutaredoxin 2 is shown to be the most effective hydrogen donor for the reduction of arsenate by ArsC.	Hydrogen	64-72	glutaredoxin 2	Homo sapiens	15-29
10572176-9	1999	A relationship between roll values and amino-amino and amino-carbonyl distances strongly suggests that electrostatics or bifurcated hydrogen-bonds could be responsible for induction of positive rolls in TpA steps.	Hydrogen	132-140	plasminogen activator, tissue type	Homo sapiens	203-206
10547320-3	1999	The comparison of the rotational constants and r(s) coordinates of the imino hydrogen atom with ones from the ab initio MO calculation at the MP2/6-31G(d, p) level of theory led to the conclusion that the spectra assigned were due to a half-chair conformer.	Hydrogen	77-85	major intrinsic protein of lens fiber	Homo sapiens	142-147
10584067-5	1999	Calculations show that the substrate binds to ALR2 through hydrogen bonds in an orientation that facilitates the stereospecific catalytic step in both models.	Hydrogen	59-67	aldo-keto reductase family 1 member B	Homo sapiens	46-50
11671255-0	1999	Electrochemistry of Macrocyclic Cobalt(III/II) Hexaamines: Electrocatalytic Hydrogen Evolution in Aqueous Solution.	Hydrogen	76-84	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	39-42
10531390-8	1999	Three-dimensional models built on the basis of the predicted structure of rhodopsin showed that Tyr(308) of the beta(2)AR covered the binding pocket formed by TM2 and TM7 from the upper side, and Thr(117) of the beta(1)AR located in the middle of the binding pocket to provide a hydrogen bonding for the beta(1)-selective agonists.	Hydrogen	279-287	rhodopsin	Homo sapiens	74-83
10512840-2	1999	Confocal fluorescence recovery after photobleaching (confocal-FRAP) was used to investigate intramolecular hydrogen bonding and electrostatic interactions in hyaluronan solutions.	Hydrogen	107-115	mechanistic target of rapamycin kinase	Homo sapiens	62-66
10512717-3	1999	The peptide adopted a beta-hairpin structure with a type I beta-turn between residues Gly4P and Gly7P, the conformation of the peptide being further stabilised by a pair of hydrogen bonds from the side-chain of Asn2P to main-chain atoms in Val9P.	Hydrogen	173-181	amyloid beta precursor protein	Homo sapiens	20-26
10496963-4	1999	The sum of the hydrogen bond acceptor strengths was calculated and correlated with EC(50) values for PGP inhibition.	Hydrogen	15-23	ATP binding cassette subfamily B member 1	Homo sapiens	101-104
10496963-6	1999	The interaction of the nitrogen atom with PGP therefore is nonional and is determined by the sum of the hydrogen acceptor strengths of the region.	Hydrogen	104-112	ATP binding cassette subfamily B member 1	Homo sapiens	42-45
10548050-5	1999	In this paper, we report the backbone dynamics of eotaxin determined through 15N-T1, T2, and [1H]-15N nuclear Overhauser effect heteronuclear multidimensional NMR experiments.	Hydrogen	94-96	C-C motif chemokine ligand 11	Homo sapiens	50-57
10497806-2	1999	Kinetic behavior during deprotonation and hydrogen/deuterium exchange reactions indicates that insulin B (ox) ions have two distinct structural types.	Hydrogen	42-50	insulin	Homo sapiens	95-102
10493789-0	1999	Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects.	Hydrogen	10-18	seed linoleate 13S-lipoxygenase-1	Glycine max	39-53
10504240-0	1999	Contribution of intra- and intermolecular hydrogen bonds to the conformational stability of human lysozyme(,).	Hydrogen	42-50	lysozyme	Homo sapiens	98-106
10480597-5	1999	The glucose is predicted to form hydrogen bond interactions with the side chains of glucokinase residues Thr 168, Lys 169, Asn 204, Asp 205, Asn 231, and Glu 290, similar to those observed for brain hexokinase I.	Hydrogen	33-41	hexokinase 1	Homo sapiens	199-211
10479306-4	1999	Molecular modeling showed additional hydrogen bond interactions provided by the (alpha-Me)pTyr residue with the Grb2 SH2 domain.	Hydrogen	37-45	growth factor receptor bound protein 2	Homo sapiens	112-116
10513557-2	1999	Both systemic capsaicin pretreatment and intravenous administration of CGRP receptor antagonist, human CGRP-(8-37), completely abolished the stimulatory effect of hepatic blood flow induced by intracisternal injection of TRH analog (RX-77368; p-Glu-His-(3,3"-dimethyl)-Pro-NH2, 100 ng), assessed by the hydrogen gas clearance method.	Hydrogen	303-311	calcitonin related polypeptide alpha	Homo sapiens	71-75
10513557-2	1999	Both systemic capsaicin pretreatment and intravenous administration of CGRP receptor antagonist, human CGRP-(8-37), completely abolished the stimulatory effect of hepatic blood flow induced by intracisternal injection of TRH analog (RX-77368; p-Glu-His-(3,3"-dimethyl)-Pro-NH2, 100 ng), assessed by the hydrogen gas clearance method.	Hydrogen	303-311	calcitonin related polypeptide alpha	Homo sapiens	103-107
10517163-9	1999	The crystal structure is stabilized by intermolecular hydrogen bonds involving NH of Val1 and carbonyl oxygen of a symmetry related (-x, y - 1/2, 1/2 + z) deltaPhe2 and NH of deltaPhe2 with carbonyl oxygen of a symmetry related (x, y1/2, 1/2 + z) Ile4.	Hydrogen	54-62	RNA, Ro60-associated Y1	Homo sapiens	232-245
10480261-7	1999	The compounds PCV, GCV, H2G and PMPA showed some activity in CD4+ T lymphocytes, but not in SupT1 cells.	Hydrogen	24-26	CD4 molecule	Homo sapiens	61-64
10927404-4	1999	The sentence should read "The out-of-plane displacement modifies the hydrogen-bonding pattern, allowing an approach of 2.21 (2) A to F2, see Table 4; the resulting increase in structural stability supports this model."	Hydrogen	69-77	coagulation factor II, thrombin	Homo sapiens	133-148
10450163-0	1999	Conformational stability of adsorbed insulin studied with mass spectrometry and hydrogen exchange.	Hydrogen	80-88	insulin	Homo sapiens	37-44
10450163-2	1999	The adsorption-induced conformational changes of insulin are studied using a combination of hydrogen/deuterium (H/D) exchange and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry.	Hydrogen	92-100	insulin	Homo sapiens	49-56
10450163-6	1999	Hydrogen-exchange experiments clearly demonstrate that the strong interaction of insulin with the hydrophobic surface is accompanied by a strong increase in the H/D-exchange rates and thus in a reduction in the insulin native structural stability.	Hydrogen	0-8	insulin	Homo sapiens	81-88
10336607-0	1999	Calcium-binding properties and molecular organization of bradykinin A solution 1H-NMR study.	Hydrogen	79-81	kininogen 1	Homo sapiens	57-67
10450163-6	1999	Hydrogen-exchange experiments clearly demonstrate that the strong interaction of insulin with the hydrophobic surface is accompanied by a strong increase in the H/D-exchange rates and thus in a reduction in the insulin native structural stability.	Hydrogen	0-8	insulin	Homo sapiens	211-218
10426379-6	1999	In conclusion, 1H and 13C NMR spectroscopy revealed intramyocellular abnormalities of lipid metabolism associated with whole body insulin resistance in subjects at high risk of developing diabetes, and might be useful tools for noninvasively monitoring these alterations in diabetes and prediabetic states.	Hydrogen	15-17	insulin	Homo sapiens	130-137
10737326-4	1999	The presence of insect specific N-glycan structures containing both alpha1,3- and alpha1,6- di-fucosylated innermost N-acetylglucosamine residue (23.3%), as below, was also confirmed by 600 MHz 1H-NMR spectroscopy.	Hydrogen	194-196	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	68-91
10439509-0	1999	Electrospray ionization mass spectrometry and hydrogen/deuterium exchange for probing the interaction of calmodulin with calcium.	Hydrogen	46-54	calmodulin 1	Homo sapiens	105-115
10439510-1	1999	Hydrogen/deuterium (H/D) exchange chemistry monitored by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is used to study solution phase conformational changes of bradykinin, alpha-melanocyte stimulating hormone, and melittin as water is added to methanol-d4, acetonitrile, and isopropanol-d8 solutions.	Hydrogen	0-8	kininogen 1	Homo sapiens	204-214
10439510-1	1999	Hydrogen/deuterium (H/D) exchange chemistry monitored by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is used to study solution phase conformational changes of bradykinin, alpha-melanocyte stimulating hormone, and melittin as water is added to methanol-d4, acetonitrile, and isopropanol-d8 solutions.	Hydrogen	0-8	proopiomelanocortin	Homo sapiens	216-252
10506884-0	1999	[In-vivo 1H-MR spectroscopy: the determination of the intra- and extramyocellular lipid content depending on the insulin effect in the direct offspring of type-2 diabetics].	Hydrogen	9-11	insulin	Homo sapiens	113-120
10506884-10	1999	CONCLUSIONS: A significantly increased intramyocellular lipid content in insulin resistant offspring of type II diabetic subjects was assessed non-invasively by 1H-MR spectroscopy.	Hydrogen	161-163	insulin	Homo sapiens	73-80
10481281-0	1999	1H, 13C and 15N resonance assignments and secondary structure of the N-terminal domain of human tissue inhibitor of metalloproteinases-1.	Hydrogen	0-2	TIMP metallopeptidase inhibitor 1	Homo sapiens	96-136
11671050-10	1999	When G has a 5"-phosphate group, rotamer distribution is also influenced by phosphate-NH(Bip) hydrogen bonds.	Hydrogen	94-102	heat shock protein family A (Hsp70) member 5	Homo sapiens	89-92
10452220-0	1999	Effects of GABA-transaminase inhibition on brain metabolism and amino-acid compartmentation: an in vivo study by 2D 1H-NMR spectroscopy coupled with microdialysis.	Hydrogen	116-118	4-aminobutyrate aminotransferase	Rattus norvegicus	11-28
10419471-11	1999	We suggest that water and polyols permeate AQP3 by forming successive hydrogen bonds with titratable sites.	Hydrogen	70-78	aquaporin 3 (Gill blood group) S homeolog	Xenopus laevis	43-47
10457450-3	1999	Only 1-3 ml min-1 of helium carrier gas from the gas chromatograph was necessary for sustaining the plasma while 0.15-1.5 ml min-1 of hydrogen was added as reagent gas.	Hydrogen	134-142	CD59 molecule (CD59 blood group)	Homo sapiens	125-130
10395831-1	1999	Hydrogen exchange results for cytochrome c have been interpreted in terms of transient hydrogen bond-breaking reactions that include large unfolding reactions and small fluctuational distortions.	Hydrogen	0-8	cytochrome c, somatic	Homo sapiens	30-42
10395831-1	1999	Hydrogen exchange results for cytochrome c have been interpreted in terms of transient hydrogen bond-breaking reactions that include large unfolding reactions and small fluctuational distortions.	Hydrogen	87-95	cytochrome c, somatic	Homo sapiens	30-42
10419058-6	1999	Selective insulin resistance and hyperinsulinism estimulates the tubular sodium-hydrogen exchanger and facilitates the active reabsorption of urate.	Hydrogen	80-88	insulin	Homo sapiens	10-17
10358065-7	1999	Our data indicate that the guanido group of Arg-120 of hPGHS-2 interacts with arachidonate through a hydrogen bond rather than an ionic bond and that this interaction is much less important for arachidonate binding to PGHS-2 than to PGHS-1.	Hydrogen	101-109	prostaglandin-endoperoxide synthase 2	Homo sapiens	55-62
10358065-7	1999	Our data indicate that the guanido group of Arg-120 of hPGHS-2 interacts with arachidonate through a hydrogen bond rather than an ionic bond and that this interaction is much less important for arachidonate binding to PGHS-2 than to PGHS-1.	Hydrogen	101-109	prostaglandin-endoperoxide synthase 2	Homo sapiens	56-62
10348919-1	1999	1H, 13C, and 15N NMR resonances of the SH2 domain of Grb2/Ash in both the free form and the form complexed with a phosphotyrosine-containing peptide derived from the EGF receptor were assigned by analysis of multi-dimensional, double- and triple-resonance NMR experiments.	Hydrogen	0-2	growth factor receptor bound protein 2	Homo sapiens	53-57
10348919-1	1999	1H, 13C, and 15N NMR resonances of the SH2 domain of Grb2/Ash in both the free form and the form complexed with a phosphotyrosine-containing peptide derived from the EGF receptor were assigned by analysis of multi-dimensional, double- and triple-resonance NMR experiments.	Hydrogen	0-2	growth factor receptor bound protein 2	Homo sapiens	58-61
10037750-15	1999	We conclude from these data that glutamine at position 188 stabilizes the UMP-GALT intermediate through hydrogen bonding and enables the double displacement of both glu-1-P and UDP-Gal.	Hydrogen	104-112	galactose-1-phosphate uridylyltransferase	Homo sapiens	78-82
10378001-3	1999	Our results are consistent with the conclusions of previous studies indicating that hypericin binds to HSA by means of a specific hydrogen-bonded interaction between its carbonyl oxygen and the N1-H of the tryptophan residue in the IIA subdomain of HSA.	Hydrogen	130-138	albumin	Homo sapiens	103-106
10378001-3	1999	Our results are consistent with the conclusions of previous studies indicating that hypericin binds to HSA by means of a specific hydrogen-bonded interaction between its carbonyl oxygen and the N1-H of the tryptophan residue in the IIA subdomain of HSA.	Hydrogen	130-138	albumin	Homo sapiens	249-252
10378001-6	1999	Energy transfer from the tryptophan residue of HSA to hypericin is very efficient and is characterized by a critical distance of 94 A, from which we estimate a time constant for energy transfer of approximately 3 x 10(-15) s. Although it is tightly bound to HSA, hypericin is still capable of executing excited-state intramolecular proton (or hydrogen atom) transfer in the approximately 5:1 complex, albeit to a lesser extent than when it is free in solution.	Hydrogen	343-351	albumin	Homo sapiens	47-50
10482174-4	1999	During ischemia, there is a metabolic mismatch between glycolysis and glucose oxidation that results in accumulation of hydrogen ions, which, in turn, activates the Na+/H+ exchange system (NHE-1), leading to Na+ and Ca2+ overload and cell death.	Hydrogen	120-128	solute carrier family 9 member A1	Homo sapiens	189-194
10231520-7	1999	Here we describe the solution structure of chicken CRP1 determined by homonuclear and 1H-15N heteronuclear magnetic resonance spectroscopy.	Hydrogen	86-88	cysteine and glycine rich protein 1	Gallus gallus	51-55
10092466-4	1999	In particular, we study the hydrogen protection factors in lysozyme studied in transient experiments by Gladwin and Evans and by Nash and Jonas using equilibrium pressure denaturation and the NMR order parameters measured by Dobson and Kim for the homologous protein alpha-lactalbumin.	Hydrogen	28-36	lactalbumin alpha	Homo sapiens	267-284
11670903-0	1999	Role of the Invariant Peptide Fragment Forming NH.S Hydrogen Bonds in the Active Site of Cytochrome P-450 and Chloroperoxidase: Synthesis and Properties of Cys-Containing Peptide Fe(III) and Ga(III) (Octaethylporphinato) Complexes as Models.	Hydrogen	52-60	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-126
10368294-9	1999	In addition, sequence changes in v-cyclin eliminate hydrogen-bonding partners for atoms of the p27(Kip1) inhibitor.	Hydrogen	52-60	dynactin subunit 6	Homo sapiens	95-98
10354286-0	1999	Insulin-dependent diabetic sibling pairs are concordant for sodium-hydrogen antiport activity.	Hydrogen	67-75	insulin	Homo sapiens	0-7
10354286-1	1999	UNLABELLED: Insulin-dependent diabetic sibling pairs are concordant for sodium-hydrogen antiport activity.	Hydrogen	79-87	insulin	Homo sapiens	12-19
10388841-1	1999	Backbone mimicry by the formation of closed-loop C7, C10 and C13 (mimics of gamma-, beta- and alpha-turns) conformations through side chain-main chain hydrogen bonds by polar groups is a frequent observation in protein structures.	Hydrogen	151-159	homeobox C10	Homo sapiens	53-56
10194369-1	1999	The bisphosphatase domain derived from the rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase was studied by 1H-13C HMQC NMR spectroscopy of the histidine C2" and H2" nuclei.	Hydrogen	121-123	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	53-105
10194369-1	1999	The bisphosphatase domain derived from the rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase was studied by 1H-13C HMQC NMR spectroscopy of the histidine C2" and H2" nuclei.	Hydrogen	175-177	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	53-105
10211818-6	1999	The ability of WAT1 to form four hydrogen bonds may explain why evolution has preserved a water molecule, rather than a side-chain atom, at the center of this intricate hydrogen bond network.	Hydrogen	33-41	MTOR associated protein, LST8 homolog	Homo sapiens	15-19
10211818-6	1999	The ability of WAT1 to form four hydrogen bonds may explain why evolution has preserved a water molecule, rather than a side-chain atom, at the center of this intricate hydrogen bond network.	Hydrogen	169-177	MTOR associated protein, LST8 homolog	Homo sapiens	15-19
10074345-7	1999	Second, the [1H,15N]HSQC NMR experiment was used to probe the interactions between p18INK4C and other proteins.	Hydrogen	13-15	cyclin dependent kinase inhibitor 2C	Homo sapiens	83-91
10049671-8	1999	1H NMR spectroscopy of rhBcl-2, both free and complexed with the Bax BH3 domain peptide, provided further evidence for the structural and functional integrity of the refolded protein.	Hydrogen	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	65-68
10074942-3	1999	Both are hydrogen-bonded to a conserved glutamate (eNOS E361, iNOS E377).	Hydrogen	9-17	nitric oxide synthase 2	Homo sapiens	62-66
10049337-4	1999	Here, 1H-NMR spectra of wild-type RNase A and the D121N and D121A variants were analyzed thoroughly as a function of pH.	Hydrogen	6-8	ribonuclease pancreatic	Bos taurus	34-41
10189177-7	1999	Recently, compounds which do not have the conventional hydrogen bonding capabilities of peptides have begun to appear in the thrombin literature.	Hydrogen	55-63	coagulation factor II, thrombin	Homo sapiens	125-133
10093213-0	1999	Conformations of protonated gas-phase bradykinin ions: evidence for intramolecular hydrogen bonding.	Hydrogen	83-91	kininogen 1	Homo sapiens	38-48
9990012-1	1999	Hen egg-white lysozyme dissolved in glycerol containing 1% water was studied by using CD and amide proton exchange monitored by two-dimensional 1H NMR.	Hydrogen	144-146	lysozyme	Homo sapiens	14-22
9931257-7	1999	The C-terminal carboxylate group of angiotensin I docked into the active-site cleft, with the last two residues extending beyond the active site, is perfectly localized to make a favorable hydrogen bond and salt bridge with the amide nitrogen of the Lys40-Phe41 peptide bond and with the epsilon-ammonium group of the Lys40 side-chain.	Hydrogen	189-197	angiotensinogen	Homo sapiens	36-49
10089402-2	1999	Two 2E8 Fab molecules in the asymmetric unit are related by noncrystallographic symmetry and are hydrogen bonded through a beta-sheet-like intermolecular contact between the heavy-chain complementarity-determining regions 3 (CDRH3) of each molecule.	Hydrogen	97-105	amyloid beta precursor protein	Homo sapiens	121-127
10048334-0	1999	Breaking the low barrier hydrogen bond in a serine protease.	Hydrogen	25-33	coagulation factor II, thrombin	Homo sapiens	44-59
18967489-2	1999	During the cathodic scan, the last one is reduced to a transient Co(0) species that catalyses the reduction of hydrogen ion to the hydrogen molecule by a mechanism alike to that emphasized for the Co(II)-sulfide ion system (F.G. Banica, N. Spataru, T. Spataru, Electroanalysis 9 (1997) 1341).	Hydrogen	111-119	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
18967489-2	1999	During the cathodic scan, the last one is reduced to a transient Co(0) species that catalyses the reduction of hydrogen ion to the hydrogen molecule by a mechanism alike to that emphasized for the Co(II)-sulfide ion system (F.G. Banica, N. Spataru, T. Spataru, Electroanalysis 9 (1997) 1341).	Hydrogen	131-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
9888793-6	1999	The second Gal-beta1,4-GlcNAc-Epo moiety was recognized via the carbohydrate-carbohydrate interaction with the first Gal-beta1, 4-GlcNAc-Epo moiety in addition to the protein-carbohydrate interaction with the "right-side" catalytic cleft of HL through a number of hydrogen bonds including water-mediated ones as well as many van der Waals contacts.	Hydrogen	264-272	erythropoietin	Homo sapiens	30-33
9888793-6	1999	The second Gal-beta1,4-GlcNAc-Epo moiety was recognized via the carbohydrate-carbohydrate interaction with the first Gal-beta1, 4-GlcNAc-Epo moiety in addition to the protein-carbohydrate interaction with the "right-side" catalytic cleft of HL through a number of hydrogen bonds including water-mediated ones as well as many van der Waals contacts.	Hydrogen	264-272	erythropoietin	Homo sapiens	137-140
10445042-6	1999	Typical azole inhibitors, such as ketoconazole, are able to fit the putative active site of CYP51 by a combination of haem ligation, hydrogen bonding, pi-pi stacking and hydrophobic interactions within the enzyme"s haem environment.	Hydrogen	133-141	sterol 14-demethylase	Saccharomyces cerevisiae S288C	92-97
9827990-1	1998	The rate constants for the processes that lead to local opening and closing of the structures around hydrogen bonds in native proteins have been determined for most of the secondary structure hydrogen bonds in the four-helix protein acyl coenzyme A binding protein.	Hydrogen	101-109	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	233-264
10576551-1	1999	The kidney is the major target of parathyroid hormone (PTH), and PTH influences the urinary excretion of calcium, phosphate and hydrogen ions.	Hydrogen	128-136	parathyroid hormone	Homo sapiens	34-53
10501470-10	1999	The paraventricular nucleus of the hypothalamus exhibited expression of corticotropin-releasing factor primary transcript that was associated with a sharp increase in the plasma corticosterone levels 1h after intravenous tumor necrosis factor-alpha administration.	Hydrogen	200-202	corticotropin releasing hormone	Rattus norvegicus	72-102
10501470-10	1999	The paraventricular nucleus of the hypothalamus exhibited expression of corticotropin-releasing factor primary transcript that was associated with a sharp increase in the plasma corticosterone levels 1h after intravenous tumor necrosis factor-alpha administration.	Hydrogen	200-202	tumor necrosis factor	Rattus norvegicus	221-248
10526369-1	1999	Three-dimensional (3D) models of four CASP3 targets were calculated using a simple modeling procedure that includes prediction of regular secondary structure, analysis of possible beta-sheet topologies, assembly of amphiphilic helices and beta-sheets to bury their nonpolar surfaces, and adjustment of side-chain conformers and loops to provide close packing and saturation of the "hydrogen bond potential" (exposure of all polar groups to water or their involvement in intramolecular hydrogen bonds).	Hydrogen	382-390	caspase 3	Homo sapiens	38-43
10526369-1	1999	Three-dimensional (3D) models of four CASP3 targets were calculated using a simple modeling procedure that includes prediction of regular secondary structure, analysis of possible beta-sheet topologies, assembly of amphiphilic helices and beta-sheets to bury their nonpolar surfaces, and adjustment of side-chain conformers and loops to provide close packing and saturation of the "hydrogen bond potential" (exposure of all polar groups to water or their involvement in intramolecular hydrogen bonds).	Hydrogen	485-493	caspase 3	Homo sapiens	38-43
9920380-0	1998	Solution structure of a fragment of the dimerization domain of DP-1 determined by 1H-nuclear magnetic resonance and distance geometry.	Hydrogen	82-84	transcription factor Dp-1	Homo sapiens	63-67
9920380-1	1998	The structure of a synthesized peptide with the sequence of NHILPNESAYDQKNIRRRVYDALNVLMAMNIISK that corresponds to residues 151-184 of transcription factor DP-1 (Girling et al., Nature 362 (1993) 83-87) was determined by 1H-nuclear magnetic resonance in water and 40% d3-trifluoroethanol/water, respectively.	Hydrogen	221-223	transcription factor Dp-1	Homo sapiens	156-160
9885896-5	1998	The peptide backbone adopted a polyproline II-like conformation with canonical hydrogen bonding between the peptide backbone and MHC II molecule.	Hydrogen	79-87	histocompatibility-2, MHC	Mus musculus	129-135
9788941-8	1998	Binding simulations of the ion at the "tight" site of H26Q mutant cytochrome c also showed integration of the ion into the protein"s hydrogen bond network.	Hydrogen	133-141	cytochrome c, somatic	Homo sapiens	66-78
9820830-5	1998	Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha).	Hydrogen	199-201	interleukin 1 beta	Rattus norvegicus	25-42
9820830-5	1998	Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha).	Hydrogen	199-201	interleukin 1 beta	Rattus norvegicus	44-52
9811813-7	1998	Our data, in conjunction with existing structural data, establish that the Abeta fibril is a hydrogen-bonded, parallel beta-sheet defining the long axis of the Abeta fibril propagation.	Hydrogen	93-101	amyloid beta precursor protein	Homo sapiens	75-80
9811813-7	1998	Our data, in conjunction with existing structural data, establish that the Abeta fibril is a hydrogen-bonded, parallel beta-sheet defining the long axis of the Abeta fibril propagation.	Hydrogen	93-101	amyloid beta precursor protein	Homo sapiens	160-165
9841654-3	1998	Results have shown that guanidylated cytochrome c readily forms a hydrophobic complex with dioleyl phosphoric acid (DOLPA) through hydrogen bonding between the phosphate moiety and the guanidinium groups.	Hydrogen	131-139	cytochrome c, somatic	Homo sapiens	37-49
9839944-6	1998	The presence of surface hydrophobic residues is confirmed by selective broadening of ethyl and aromatic signals in the 1H-NMR spectrum on the addition of the paramagnetic probe 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-N-oxy, OH-TEMPO, to wild-type TIMP-1.	Hydrogen	119-121	TIMP metallopeptidase inhibitor 1	Homo sapiens	248-254
9827990-1	1998	The rate constants for the processes that lead to local opening and closing of the structures around hydrogen bonds in native proteins have been determined for most of the secondary structure hydrogen bonds in the four-helix protein acyl coenzyme A binding protein.	Hydrogen	192-200	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	233-264
9782052-8	1998	Comparisons to other ankyrin-repeat-containing proteins (GABPbeta, 53BP2 and myotrophin) show similar structures with comparable hydrogen-bonding patterns and hydrophobic interactions.	Hydrogen	129-137	myotrophin	Homo sapiens	57-87
9778355-0	1998	Secondary structure of the exchange-resistant core from the nicotinic acetylcholine receptor probed directly by infrared spectroscopy and hydrogen/deuterium exchange.	Hydrogen	138-146	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	60-92
9778355-4	1998	Further exposure of the nAChR to 2H2O under conditions of both increasing pH and membrane "fluidity" led to additional exchange of peptide hydrogens for deuterium.	Hydrogen	139-148	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	24-29
9778355-5	1998	The greatest degree of peptide 1H/2H exchange (95%) under nondenaturing conditions was found for the nAChR reconstituted into the highly fluid egg phosphatidylcholine membranes lacking cholesterol and anionic lipids at pH 9.0.	Hydrogen	31-33	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	101-106
9833679-1	1998	The solution structure of a synthetic ET(B) selective agonist, ET-1[Cys(Acm)(1,15), Ala3, Leu7, dAsp8, Aib11] has been solved by 1H NMR and molecular modelling studies.	Hydrogen	129-131	endothelin receptor type B	Homo sapiens	38-43
9839011-3	1998	Of the three residues (Tyr 48, His 110, and Trp 111) that can form hydrogen bonds with the ionized portion of aldose reductase inhibitors, protonated His110 appears to play an important role in directing charged inhibitors to bind at the active site through charge interaction.	Hydrogen	67-75	aldo-keto reductase family 1 member B	Homo sapiens	110-126
9776086-3	1998	1H-NMR distinguished biochemical differences in regenerating muscles that were consistent with the extent of repair in three strains: mdx dystrophic mice; MyoD(-/-) mice that lack expression of the early myogenic regulatory gene MyoD; and a double-mutant mdx:MyoD(-/-) strain lacking expression of both MyoD and dystrophin.	Hydrogen	0-2	dystrophin, muscular dystrophy	Mus musculus	312-322
9833679-1	1998	The solution structure of a synthetic ET(B) selective agonist, ET-1[Cys(Acm)(1,15), Ala3, Leu7, dAsp8, Aib11] has been solved by 1H NMR and molecular modelling studies.	Hydrogen	129-131	endothelin 1	Homo sapiens	63-67
9833679-1	1998	The solution structure of a synthetic ET(B) selective agonist, ET-1[Cys(Acm)(1,15), Ala3, Leu7, dAsp8, Aib11] has been solved by 1H NMR and molecular modelling studies.	Hydrogen	129-131	beta-1,3-glucuronyltransferase 1	Homo sapiens	90-94
9751723-3	1998	A hydrogen bond between residues 128 and 178 provides a structural basis for the observed highly specific influence of a polymorphism in position 129 in human PrP on the disease phenotype that segregates with the mutation Asp-178-Asn.	Hydrogen	2-10	prion protein	Homo sapiens	159-162
9735295-14	1998	(3) Three well-ordered water molecules in hydrogen bond distance to side-chains of the catalytic triad may be significant for the proton release steps in DADH catalysis.A ternary structure-based sequence alignment with ten members of the SDR family with known three-dimensional structure has suggested to define a model consisting of four groups of residues, which relates the observed low degree of sequence identity to quite similar folding patterns and nearly identical distributions of residues involved in catalysis.	Hydrogen	42-50	Alcohol dehydrogenase	Drosophila melanogaster	154-158
9753463-1	1998	Calcium activation of the C-terminal domain of calmodulin was studied using 1H and 15N NMR spectroscopy.	Hydrogen	76-78	calmodulin 1	Homo sapiens	47-57
9814852-0	1998	NHE-1 is the sodium-hydrogen exchanger isoform present in erythroid cells.	Hydrogen	20-28	solute carrier family 9 member A1	Homo sapiens	0-5
9737858-7	1998	The oxygens of the residue to be glycosylated and several flanking residues may also be involved in a set of hydrogen bonds with the GalNAc-T1 and -T3 transferases.	Hydrogen	109-117	polypeptide N-acetylgalactosaminyltransferase 1	Homo sapiens	133-150
9726949-0	1998	Contributions of a highly conserved VH/VL hydrogen bonding interaction to scFv folding stability and refolding efficiency.	Hydrogen	42-50	immunglobulin heavy chain variable region	Homo sapiens	74-78
29711438-1	1998	Cooperative strong negatively charged and neutral O-H   O as well as weak charge-assisted C-Hdelta+    Odelta- hydrogen-bonding interactions have been utilized for the crystal engineering of organometallic FeII /CoIII and FeII /CrI sandwich complexes.	Hydrogen	111-119	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	212-217
9796859-3	1998	Therefore, 1H NMR techniques in conjunction with molecular modelling have been used here to determine the solution structure of Tat(1-9), I5-Tat(1-9) and L6-Tat(1-9) and to examine the influence of amino acid exchanges on structural features of these peptides.	Hydrogen	11-13	solute carrier family 26 member 8	Homo sapiens	128-135
9858895-6	1998	MDA-MB-453 and Novikoff cells contain cytsolic glycerol 3-phosphate dehydrogenase which is associated with glyceraldehyde 3-phosphate dehydrogenase within the glycolytic enzyme complex and which is responsible for the transport of cytoslic hydrogen in the mitochondria.	Hydrogen	70-78	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	107-147
9801813-2	1998	TSA 1 contains a bicyclo[2.2.1]heptene ring system that mimics the boat conformation of the Diels-Alder transition state and is designed to bind tightly to antibodies, nucleic acids, and imprinted polymers by means of hydrogen bonds and salt-bridges.	Hydrogen	218-226	lymphocyte antigen 6 family member E	Homo sapiens	0-5
9751532-9	1998	CONCLUSION: Blockade of P-selectin resulted in decreased hepatocellular injury and increased survival in our model of uncontrolled HS.	Hydrogen	131-133	selectin P	Rattus norvegicus	24-34
9745898-0	1998	Delineation of conformational preferences in human salivary statherin by 1H, 31P NMR and CD studies: sequential assignment and structure-function correlations.	Hydrogen	73-75	statherin	Homo sapiens	60-69
9731770-1	1998	It has been suggested that three partially unfolded forms detected in a native state hydrogen exchange study of oxidized cytochrome c may represent sequential intermediates in an unfolding-refolding pathway.	Hydrogen	85-93	cytochrome c, somatic	Homo sapiens	121-133
9712875-3	1998	Among these, the analog [Bpa1,Nle8,18,Arg13,26,27,L-2-Nal23,Tyr34]bPTH-(1-34)N H2 (Bpa1-PTH-(1-34)) displayed in vitro activity with potency similar to that of PTH-(1-34).	Hydrogen	79-81	parathyroid hormone	Homo sapiens	67-70
9712875-3	1998	Among these, the analog [Bpa1,Nle8,18,Arg13,26,27,L-2-Nal23,Tyr34]bPTH-(1-34)N H2 (Bpa1-PTH-(1-34)) displayed in vitro activity with potency similar to that of PTH-(1-34).	Hydrogen	79-81	parathyroid hormone	Homo sapiens	88-91
9736447-0	1998	Endothelin-1 and NO2/NO3 circulating levels after short-term (1h) oxygen supplementation in patients with chronic respiratory failure during long-term oxygen treatment (LTOT).	Hydrogen	62-64	endothelin 1	Homo sapiens	0-12
9731235-4	1998	In this communication, we describe the use of a novel methodology, based on 1H NMR spectroscopy, to study the PLTP-induced size changes in the HDL particles.	Hydrogen	76-78	phospholipid transfer protein	Homo sapiens	110-114
9745898-1	1998	Membrane-induced solution structure of human salivary statherin, a 43 amino acid residue acidic phosphoprotein, has been investigated by two-dimensional proton nuclear magnetic resonance (2D 1H NMR) spectroscopy.	Hydrogen	191-193	statherin	Homo sapiens	54-63
9727864-11	1998	The molecules are packed in an anti-parallel manner to generate N2-H2...O2 (-x, y -1/2, -z + 3/2) and N3epsilon1-H3epsilon1 ...O1(-X, y -1/2, -z + 3/2) hydrogen bonds.	Hydrogen	152-160	small Cajal body-specific RNA 9	Homo sapiens	136-150
9699636-0	1998	Important role of hydrogen bonds in the structurally polarized transition state for folding of the src SH3 domain.	Hydrogen	18-26	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	99-102
9699636-2	1998	Here we report that this picture does not hold generally: a hydrogen bond network involving two beta-turns and an adjacent hydrophobic cluster appear to be formed in the folding transition state of the src SH3 domain, while the remainder of the polypeptide chain is largely unstructured.	Hydrogen	60-68	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	202-205
9653199-4	1998	The purified recombinant enzyme (APR1p) can use GSH efficiently as a hydrogen donor in vitro, showing aKm[GSH] approximately of 0.6 mM.	Hydrogen	69-77	MAGE family member H1	Homo sapiens	33-38
9677298-5	1998	The hydrophobic clusters enable at least partial burial of many side-chains exposed by the loss of tertiary contacts on denaturation and provide models that may explain the experimentally observed protection of amides from hydrogen exchange and the existence of residual secondary structure in non-native species of lysozyme.	Hydrogen	223-231	lysozyme	Homo sapiens	316-324
9657677-8	1998	Novel N-TIMP-1-dependent changes in hydrogen bonding near the active site of MMP-3(DeltaC) are reported.	Hydrogen	36-44	TIMP metallopeptidase inhibitor 1	Homo sapiens	6-14
9653114-5	1998	The binding between the Sec7 domain and a soluble, truncated version of human Arf-1 was investigated by examining 1H-15N and 1H-13C chemical shift changes between the native protein and the Sec7/Arf-1 complex.	Hydrogen	114-116	cytohesin 1	Homo sapiens	24-28
9653114-5	1998	The binding between the Sec7 domain and a soluble, truncated version of human Arf-1 was investigated by examining 1H-15N and 1H-13C chemical shift changes between the native protein and the Sec7/Arf-1 complex.	Hydrogen	125-127	cytohesin 1	Homo sapiens	24-28
9657677-8	1998	Novel N-TIMP-1-dependent changes in hydrogen bonding near the active site of MMP-3(DeltaC) are reported.	Hydrogen	36-44	matrix metallopeptidase 3	Homo sapiens	77-82
9711498-1	1998	Based on the absorbance change of indicators with the concentration of hydrogen ion released from an enzyme-catalyzed reaction, a convenient colorimetric method was established for the assay of acidic phospholipase A2 and glycogen phosphorylase b.	Hydrogen	71-79	phospholipase A2 group IB	Homo sapiens	201-217
9642266-2	1998	The x-ray crystal structure of the N-lobe of human serum transferrin has shown that there is a hydrogen bond network, the so-called "second shell," around the transferrin iron binding site.	Hydrogen	95-103	transferrin	Homo sapiens	57-68
9642266-2	1998	The x-ray crystal structure of the N-lobe of human serum transferrin has shown that there is a hydrogen bond network, the so-called "second shell," around the transferrin iron binding site.	Hydrogen	95-103	transferrin	Homo sapiens	159-170
9700022-3	1998	This can be concluded from [1H]NMR experiments (an upfield shift of the PEO proton signal was found at FNa concentrations below the CMC of FNa), surface tension measurements (absence of a critical association concentration) and cloud point temperature determinations.	Hydrogen	28-30	twinkle mtDNA helicase	Homo sapiens	72-75
9644264-9	1998	Furthermore, strong hydrogen bonding of flavin at the N(1) moiety with the hydroxyl group of Thr136 in MCAD is probably responsible for the strong bond of the C(4a)=C(10a) of reduced flavin in the dehydrogenase.	Hydrogen	20-28	acyl-CoA dehydrogenase medium chain	Homo sapiens	103-107
9642094-7	1998	The Gly-1 carbonyl oxygen displays two hydrogen bonds.	Hydrogen	39-47	threonine aldolase GLY1	Saccharomyces cerevisiae S288C	4-9
9657677-9	1998	N-TIMP-1 binding causes the amide of Tyr223 of MMP-3(DeltaC) bound by N-TIMP-1 to exchange with water rapidly, implying a lack of the hydrogen bond observed in the crystal structure.	Hydrogen	134-142	TIMP metallopeptidase inhibitor 1	Homo sapiens	0-8
9657677-9	1998	N-TIMP-1 binding causes the amide of Tyr223 of MMP-3(DeltaC) bound by N-TIMP-1 to exchange with water rapidly, implying a lack of the hydrogen bond observed in the crystal structure.	Hydrogen	134-142	matrix metallopeptidase 3	Homo sapiens	47-52
9657677-10	1998	The backbone amide proton of Asn162 becomes protected from rapid exchange upon forming a complex with N-TIMP-1 and could form a hydrogen bond to N-TIMP-1.	Hydrogen	128-136	TIMP metallopeptidase inhibitor 1	Homo sapiens	145-153
9657677-11	1998	N-TIMP-1 binding dramatically increases the rate of amide hydrogen exchange of Asp177 of the fifth beta strand of MMP-3(DeltaC), disrupting its otherwise stable hydrogen bond.	Hydrogen	58-66	TIMP metallopeptidase inhibitor 1	Homo sapiens	0-8
9657677-11	1998	N-TIMP-1 binding dramatically increases the rate of amide hydrogen exchange of Asp177 of the fifth beta strand of MMP-3(DeltaC), disrupting its otherwise stable hydrogen bond.	Hydrogen	58-66	matrix metallopeptidase 3	Homo sapiens	126-127
9657677-11	1998	N-TIMP-1 binding dramatically increases the rate of amide hydrogen exchange of Asp177 of the fifth beta strand of MMP-3(DeltaC), disrupting its otherwise stable hydrogen bond.	Hydrogen	161-169	TIMP metallopeptidase inhibitor 1	Homo sapiens	0-8
9622505-0	1998	Solution structure of the cytoplasmic domain of the human CD4 glycoprotein by CD and 1H NMR spectroscopy: implications for biological functions.	Hydrogen	85-87	CD4 molecule	Homo sapiens	58-61
9622505-2	1998	Here the structure of a synthetic 38 amino acid peptide corresponding to the complete cytoplasmic domain of CD4 (CD4CYTO) has been investigated under a variety of solution conditions using a combination of circular dichroism and homonuclear two-dimensional 1H nuclear magnetic resonance spectroscopy.	Hydrogen	257-259	CD4 molecule	Homo sapiens	108-111
9622505-2	1998	Here the structure of a synthetic 38 amino acid peptide corresponding to the complete cytoplasmic domain of CD4 (CD4CYTO) has been investigated under a variety of solution conditions using a combination of circular dichroism and homonuclear two-dimensional 1H nuclear magnetic resonance spectroscopy.	Hydrogen	257-259	CD4 molecule	Homo sapiens	113-120
9871733-3	1998	X-ray crystallographic and NMR examination of the complex formed between (1) and the src SH2 domain revealed a hemithioacetal formed by addition of the thiol to the aldehyde group with an additional stabilizing hydrogen bond between the acetal hydroxyl and a backbone carbonyl.	Hydrogen	211-219	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	85-88
9841506-3	1998	A human urinary compound that reverses multidrug resistance and blocks [3H]azidopine photolabeling of P-glycoprotein was purified to homogeneity and identified by 1H-NMR and mass spectrometry as the synthetic surfactant nonylphenol ethoxylate (NPE).	Hydrogen	163-165	ATP binding cassette subfamily B member 1	Homo sapiens	102-116
9592168-3	1998	A three-dimensional structure for XPA-MBD was generated using distance geometry and simulated annealing methods from NOE-based distance restraints, hydrogen bond and Zn-S distance restraints, and dihedral restraints.	Hydrogen	148-156	XPA, DNA damage recognition and repair factor	Homo sapiens	34-37
9636705-1	1998	1H and 31P NMR spectroscopy have been used together with molecular modelling to determine the fine structure of a non-palindromic 16 bp DNA containing the NF-kappa B binding site.	Hydrogen	0-2	nuclear factor kappa B subunit 1	Homo sapiens	155-165
9610364-3	1998	Hydrogen peroxide treatment for 1h with or without zinc increased both Bcl-2 and Bax proteins.	Hydrogen	32-34	BCL2 apoptosis regulator	Homo sapiens	71-76
9610364-3	1998	Hydrogen peroxide treatment for 1h with or without zinc increased both Bcl-2 and Bax proteins.	Hydrogen	32-34	BCL2 associated X, apoptosis regulator	Homo sapiens	81-84
9601073-3	1998	Two-dimensional 1H-13C NMR spectroscopy of the complexes formed by the derivatized cytochromes with cytochrome b5 and cytochrome c peroxidase has been used to investigate the number and identity of lysine residues of cytochrome c that are involved in interprotein interactions of cytochrome c. The NMR data are incompatible with simple static models proposed previously for the complexes formed by these proteins, but are consistent with the presence of multiple, interconverting complexes of comparable stability, consistent with studies employing Brownian dynamics to model the complexes.	Hydrogen	16-18	cytochrome b5 type A	Bos taurus	100-113
9602041-0	1998	1H NMR studies of azide binding to cytochrome c.	Hydrogen	0-2	cytochrome c, somatic	Homo sapiens	35-47
9782385-0	1998	1H- and 2H-NMR studies of a fragment of PMP1, a regulatory subunit associated with the yeast plasma membrane H(+)-ATPase.	Hydrogen	0-2	proteolipid ATPase	Saccharomyces cerevisiae S288C	40-44
9593190-7	1998	The main structural feature is a hydrogen bond found also in the X-ray structure of the complex maize nsLTP/palmitate between the hydroxyl of Tyr81 and the carbonyl of the lipid.	Hydrogen	33-41	LOC100283691	Zea mays	102-107
9554882-2	1998	1H NMR chemical shift assignments for the mammalian NK1 receptor-selective agonists alpha-neurokinin (NKA) and beta-neurokinin (NKB) as well as the mammalian NK1 receptor-selective antagonists [d-Pro2,d-Phe7,d-Trp9]SP and [d-Arg1, d-Pro2,d-Phe7,d-His9]SP have been determined at 600 MHz in sodium dodecyl sulfate (SDS) micelles.	Hydrogen	0-2	tachykinin precursor 1	Homo sapiens	52-100
9554882-2	1998	1H NMR chemical shift assignments for the mammalian NK1 receptor-selective agonists alpha-neurokinin (NKA) and beta-neurokinin (NKB) as well as the mammalian NK1 receptor-selective antagonists [d-Pro2,d-Phe7,d-Trp9]SP and [d-Arg1, d-Pro2,d-Phe7,d-His9]SP have been determined at 600 MHz in sodium dodecyl sulfate (SDS) micelles.	Hydrogen	0-2	tachykinin precursor 1	Homo sapiens	102-105
9605187-1	1998	Carbonic anhydrase II (CA-II), an enzyme that catalyzes hydration of carbon dioxide to bicarbonate and hydrogen ions, is located exclusively in cholangiocytes in the liver.	Hydrogen	103-111	carbonic anhydrase 2	Mus musculus	0-21
9605187-1	1998	Carbonic anhydrase II (CA-II), an enzyme that catalyzes hydration of carbon dioxide to bicarbonate and hydrogen ions, is located exclusively in cholangiocytes in the liver.	Hydrogen	103-111	carbonic anhydrase 2	Mus musculus	23-28
9514759-1	1998	The structural stability of recombinant human growth hormone (rhGH) has been studied by differential scanning calorimetry, circular dichroism and by following the tyrosine and histidine chemical shifts in the 1H NMR spectrum.	Hydrogen	209-211	growth hormone 1	Homo sapiens	46-60
9568892-7	1998	This is true in both the wild-type and CP51/46 forms of the protein, and the hydrogen bonding interaction might thus help nucleate closure of the loop.	Hydrogen	77-85	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	39-43
9675879-2	1998	The initial reaction rate is linearly dependent on cytochrome c and H2O2 concentration; the reaction follows the Michaelis and Menten kinetics both for H2O2 and hydrogen donors.	Hydrogen	161-169	cytochrome c, somatic	Homo sapiens	51-63
9499782-15	1998	This mutation, characteristic of bulky carcinogens, substituted phenylalanine for cysteine 277, a residue that participates in hydrogen bonding to the p53 DNA binding consensus sequence.	Hydrogen	127-135	tumor protein p53	Homo sapiens	151-154
9559655-0	1998	Solution conformation of an ET(B) selective agonist, ET-1[Cys(Acm)1,15,Ala3,Leu7,Aib11], in CD3OH/H2O by 1H NMR and molecular modelling.	Hydrogen	105-107	beta-1,3-glucuronyltransferase 1	Homo sapiens	76-80
9871590-2	1998	It was revealed that the methyl group at the three carbon bridge of (-)-huperzine A can form a weak hydrogen bond with the phenol hydroxyl oxygen of Tyr121 and the main-chain oxygen of Gly118 of AChE, respectively.	Hydrogen	100-108	acetylcholinesterase (Cartwright blood group)	Homo sapiens	195-199
9520384-5	1998	In the RNase A dimer, the 3-stranded beta sheets of the two subunits are hydrogen-bonded at their edges to form a continuous 6-stranded sheet across the dimer interface; in the BS-RNase dimer, it is instead the two helices that abut.	Hydrogen	73-81	ribonuclease pancreatic	Bos taurus	7-14
9449681-6	1998	Bisphenols with two hydroxyl groups in the para position and an angular configuration are suitable for appropriate hydrogen bonding to the acceptor site of the estrogen receptor.	Hydrogen	115-123	estrogen receptor 1	Homo sapiens	160-177
9490052-2	1998	NOE and rotating-frame NOE (ROE) cross peaks between protein protons and protons of bound water molecules were observed in two-dimensional H2O-ROE/NOE-1H,15N-heteronuclear single quantum coherence spectra recorded from a uniformly 13C/15N-enriched sample of bovine heart FABP.	Hydrogen	151-153	fatty acid binding protein 3	Bos taurus	271-275
9498807-0	1998	[1H,13C] NMR determination of the order of lobe loading of human transferrin with iron: comparison with other metal ions.	Hydrogen	1-3	transferrin	Homo sapiens	65-76
9445403-0	1998	Hydrogen bonding changes of internal water molecules in rhodopsin during metarhodopsin I and metarhodopsin II formation.	Hydrogen	0-8	rhodopsin	Homo sapiens	56-65
9533627-1	1998	Recent hydrogen exchange experiments on native cytochrome c implicate a sequential unfolding pathway in contrast to a simple two-state process.	Hydrogen	7-15	cytochrome c, somatic	Homo sapiens	47-59
9484220-5	1998	On the basis of the effects of Co(III) hexammine on the 1H NMR spectrum and results of automatic docking into the IRE model, the IRE bound Co(III) hexammine at the pocket in the major groove; Mg2+ may bind to the IRE at the same site on the basis of an analogy to Co(III) hexammine and on the Mg2+ inhibition of Cu-(phen)2 cleavage at the site.	Hydrogen	56-58	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	139-146
9484220-5	1998	On the basis of the effects of Co(III) hexammine on the 1H NMR spectrum and results of automatic docking into the IRE model, the IRE bound Co(III) hexammine at the pocket in the major groove; Mg2+ may bind to the IRE at the same site on the basis of an analogy to Co(III) hexammine and on the Mg2+ inhibition of Cu-(phen)2 cleavage at the site.	Hydrogen	56-58	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	31-37
9477968-5	1998	We suggest that the formation of cooperative hydrogen-bonded networks by deprotonated and protonated PG in the vesicle surface retards the binding of cyt c to the liposome surface.	Hydrogen	45-53	cytochrome c, somatic	Homo sapiens	150-155
9490052-7	1998	In the delipidated heart FABP additional contacts between water molecules and NH protons could be observed using a three-dimensional rotating frame Overhauser 1H,15N heteronuclear single quantum coherence experiment obtained with a 15N-labeled sample of apo-heart FABP.	Hydrogen	159-161	fatty acid binding protein 3	Bos taurus	25-29
9514249-3	1998	Nondenaturing gel electrophoresis and 1D 1H NMR studies of (CAG)5 and (CAG)6 reveal the presence of hairpins and mismatched duplexes as the major and minor populations respectively.	Hydrogen	41-43	R3H domain containing 2	Homo sapiens	71-76
9448728-6	1998	The stereochemistry of the hydrogen which was removed from C-11 during the conversion of linoleic acid into hydroxy acids in the presence of PGHS-1 or PGHS-2 was determined by incubation of [(11R)-2H]- and [(11S)-2H]linoleic acids followed by mass spectrometric analysis of the isotope contents of the individual hydroxy acid isomers.	Hydrogen	27-35	prostaglandin-endoperoxide synthase 1	Homo sapiens	141-147
9464364-6	1998	The reactivity of the complex to model nucleobases 9-ethylguanine (9-EtGH) and 1-methylcytosine (1-MeC) has been investigated by 1H NMR spectroscopy at 45 degrees C in aqueous media.	Hydrogen	129-131	C-C motif chemokine ligand 28	Homo sapiens	99-102
9454604-1	1998	The role of noncovalent interactions in the catalytic mechanism of aldose reductase from the yeast Candida tenuis was determined by steady-state kinetic analysis of the NADH-dependent reduction of various aldehydes, differing in hydrophobicity and the hydrogen bonding capability with the binary enzyme-NADH complex.	Hydrogen	252-260	aldo-keto reductase family 1 member B	Homo sapiens	67-83
9448728-6	1998	The stereochemistry of the hydrogen which was removed from C-11 during the conversion of linoleic acid into hydroxy acids in the presence of PGHS-1 or PGHS-2 was determined by incubation of [(11R)-2H]- and [(11S)-2H]linoleic acids followed by mass spectrometric analysis of the isotope contents of the individual hydroxy acid isomers.	Hydrogen	27-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	151-157
9448728-9	1998	It is concluded that the initial steps of the PGHS-2- and PGHS-1-catalyzed oxygenations proceed with identical stereochemistry and involve stereospecific removal of the pro-S hydrogen from the omega 8-methylene group of the substrate.	Hydrogen	175-183	prostaglandin-endoperoxide synthase 2	Homo sapiens	46-52
9448728-9	1998	It is concluded that the initial steps of the PGHS-2- and PGHS-1-catalyzed oxygenations proceed with identical stereochemistry and involve stereospecific removal of the pro-S hydrogen from the omega 8-methylene group of the substrate.	Hydrogen	175-183	prostaglandin-endoperoxide synthase 1	Homo sapiens	58-64
9422719-9	1998	Based on this data and our earlier observations, we propose a model for the orientation of ligand within the binding pocket of ER in which the A-ring 3-phenol of estradiol is hydrogen bonded to Glu353 in helix-3 and the 17beta-hydroxyl of estradiol is hydrogen bonded to His524 in helix-11.	Hydrogen	175-183	estrogen receptor 1	Homo sapiens	127-129
9492317-7	1998	1H-NMR selective line broadening was apparent for several of the angiotensin II protons upon titration of an aqueous sample with less than stoichiometric amounts of 1,2-dimyristoyl-sn-glycero-3-phosphocholine bilayer vesicles.	Hydrogen	0-2	angiotensinogen	Homo sapiens	65-79
9422719-9	1998	Based on this data and our earlier observations, we propose a model for the orientation of ligand within the binding pocket of ER in which the A-ring 3-phenol of estradiol is hydrogen bonded to Glu353 in helix-3 and the 17beta-hydroxyl of estradiol is hydrogen bonded to His524 in helix-11.	Hydrogen	252-260	estrogen receptor 1	Homo sapiens	127-129
14517473-1	1998	The conformational requirements of suramin for its binding to basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) were examined by molecular modeling and docking simulations using the conformational features of suramin determined by the present proton nuclear magnetic resonance (1H-NMR) studies and the crystal structures of growth factors reported previously.	Hydrogen	308-310	fibroblast growth factor 2	Homo sapiens	62-92
9417062-1	1998	The M121H azurin mutant in solution presents various species in equilibrium that can be detected and studied by 1H NMR of the Cu(II) and Co(II) paramagnetic metalloderivatives.	Hydrogen	7-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-143
14517473-1	1998	The conformational requirements of suramin for its binding to basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) were examined by molecular modeling and docking simulations using the conformational features of suramin determined by the present proton nuclear magnetic resonance (1H-NMR) studies and the crystal structures of growth factors reported previously.	Hydrogen	308-310	fibroblast growth factor 2	Homo sapiens	94-98
14517473-7	1998	The interaction of suramin with bFGF or PDGF primarily involves ion-pair, hydrophobic and hydrogen bonding interactions, in addition to van der Waals" contacts.	Hydrogen	90-98	fibroblast growth factor 2	Homo sapiens	32-36
9454576-8	1998	Another structural feature stabilizing the loop, in the case of the B3P-G3PDH complex, is a hydrogen bond between the side chains of Y8 and D10 associated with a beta-turn of residues 8-11.	Hydrogen	92-100	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	72-77
9450557-10	1997	Hydrogen-deuterium exchange experiments show that all the slowly exchanging backbone amide protons in the IGF-I domain are either in the helical or the extended structural elements.	Hydrogen	0-8	insulin like growth factor 1	Homo sapiens	106-111
9433185-4	1998	In contrast, histatin 5 prefers largely alpha-helical conformation in dimethyl sulfoxide solution as evident from the JNH-C alpha H values (&lt; or = 6.4 Hz), slow 1H/2H exchange, low d delta/dT values (&lt; or = 0.003 ppm K-1) observed for amide resonances of residues 6-24, and the characteristic NH-NH (i, i + 1) and C alpha H-C beta H (i, i + 3) NOE connectivities.	Hydrogen	164-166	histatin 3	Homo sapiens	13-23
9449318-6	1998	Perturbation of helical hydrogen bonding in the residues before P14 (Aib10-P14, alamethicin; T11-P14, melittin) was characterized in both peptides by variable hydrogen bond patterns that included pi and gamma hydrogen bonds.	Hydrogen	24-32	cyclin dependent kinase inhibitor 2A	Homo sapiens	64-67
9449318-6	1998	Perturbation of helical hydrogen bonding in the residues before P14 (Aib10-P14, alamethicin; T11-P14, melittin) was characterized in both peptides by variable hydrogen bond patterns that included pi and gamma hydrogen bonds.	Hydrogen	24-32	cyclin dependent kinase inhibitor 2A	Homo sapiens	69-78
9568380-17	1998	We propose that, similar to a previous model for cationic inhibitors of AChE (13), the P = O delta- group of Me forms hydrogen bonds within the oxyanion-hole causing the leaving group (-SCH3) to orient towards the "gorge" opening.	Hydrogen	118-126	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-76
9449322-0	1998	Photoactivation of rhodopsin causes an increased hydrogen-deuterium exchange of buried peptide groups.	Hydrogen	49-57	rhodopsin	Homo sapiens	19-28
9449322-2	1998	In order to explore the nature of these conformational changes, time-resolved Fourier transform infrared spectroscopy was used to measure the kinetics of hydrogen/deuterium exchange in rhodopsin upon photoexcitation.	Hydrogen	154-162	rhodopsin	Homo sapiens	185-194
9398185-0	1997	NMR studies of the role of hydrogen bonding in the mechanism of triosephosphate isomerase.	Hydrogen	27-35	triosephosphate isomerase 1	Homo sapiens	64-89
9391046-7	1997	Backbone dynamics studies done by using the heteronuclear [1H]-15N nuclear Overhauser effect indicate that almost half of PrP(29-231), residues 29-124, is highly flexible.	Hydrogen	59-61	major prion protein	Mesocricetus auratus	122-125
9398185-7	1997	15N-labeled PGH was synthesized and the NH proton of free [15N]PGH shows a single 1H-15N HMQC cross peak with delta (1H) = 10.3 ppm and delta (15N) = 168 ppm which shifts to delta (1H) = 10.9 ppm and delta (15N) = 174 ppm in the TIM complex of [15N]PGH.	Hydrogen	82-84	triosephosphate isomerase 1	Homo sapiens	229-232
9398185-10	1997	This resonance shows a pH-independent exchange rate with water (kex = 3900 s-1 at 30 degrees C, Eact = 8.9 kcal/mol) which may reflect the dissociation of the TIM-PGH complex, and meets the criteria for a low-barrier hydrogen bond on the basis of the significant downfield shift of 6.2 ppm from the NOH proton of the model compound acetohydroxamic acid, and a very low fractionation factor phi = 0.38 +/- 0.06.	Hydrogen	217-225	triosephosphate isomerase 1	Homo sapiens	159-162
9398185-2	1997	TIM and its complexes with the reactive intermediate analogs, phosphoglycolic acid (PGA) and phosphoglycolohydroxamic acid (PGH), were studied by 1H NMR at 600 MHz and at low temperature (-4.8 degrees C).	Hydrogen	146-148	triosephosphate isomerase 1	Homo sapiens	0-3
9398185-13	1997	A low-barrier hydrogen bond from PGH NOH to Glu-165 suggests a dual role for Glu-165 in catalysis of proton transfer not only between the C1 and C2 carbons but also between the O1 and O2 oxygens in the interconversion of DHAP and GAP in wild type TIM.	Hydrogen	14-22	triosephosphate isomerase 1	Homo sapiens	247-250
9398185-4	1997	In the TIM-PGH complex, His-95 N epsilon H shows a slow, pH-independent exchange rate with water (kex = 80 s-1 at 30 degrees C, Eact = 19 kcal/mol), which is 44-fold slower than that of an exposed histidine suggesting partial shielding from bulk solvent, and a fractionation factor phi = 0.71 +/- 0.02 consistent with its donation of a normal hydrogen bond.	Hydrogen	343-351	triosephosphate isomerase 1	Homo sapiens	7-10
9461349-7	1997	The similarity in behaviour of hPTHrP(1-34) and the N-terminal fragments of PTH under various solution conditions is shown from the 1H NMR data presented here and an extensive review of the literature data.	Hydrogen	132-134	parathyroid hormone	Homo sapiens	32-35
9467970-1	1997	To understand the structural requirements for the biological activity of endothelin peptides and to develop receptor selective endothelin analogues further, the solution structure of the bicyclic 21 amino acid residue vasoactive peptide, endothelin-1, has been determined in methanol-d3/water using high-resolution 1H-NMR spectroscopy.	Hydrogen	315-317	endothelin 1	Homo sapiens	238-250
9400368-8	1997	Modeling of substrate at the chymase active site suggests that binding energy may be gained by three main-chain hydrogen bonds provided by substrate residues P2" and P4" and that discriminating interactions with substrate side chains are also likely.	Hydrogen	112-120	chymase 1	Homo sapiens	29-36
9367160-9	1997	Our analysis also shows that folding of a beta-hairpin captures much of the basic physics of protein folding, including stabilization by hydrogen bonding and hydrophobic interactions, two-state behaviour, and a funnel-like, partially rugged energy landscape.	Hydrogen	137-145	amyloid beta precursor protein	Homo sapiens	40-46
9376376-6	1997	These difference features are assigned to one or more tryptophan residues that reside in a hydrophobic, weakly hydrogen-bonding environment in rhodopsin and that are transferred to a less hydrophobic, non-hydrogen-bonding environment during rhodopsin activation.	Hydrogen	111-119	rhodopsin	Homo sapiens	143-152
9376376-6	1997	These difference features are assigned to one or more tryptophan residues that reside in a hydrophobic, weakly hydrogen-bonding environment in rhodopsin and that are transferred to a less hydrophobic, non-hydrogen-bonding environment during rhodopsin activation.	Hydrogen	205-213	rhodopsin	Homo sapiens	241-250
9398224-0	1997	Kinetics of cytochrome c folding examined by hydrogen exchange and mass spectrometry.	Hydrogen	45-53	cytochrome c, somatic	Homo sapiens	12-24
9398224-1	1997	Pulsed hydrogen exchange/mass spectrometry, a new method for studying protein folding, has been used to investigate folding of cytochrome c on the 5 ms to 15 s time scale.	Hydrogen	7-15	cytochrome c, somatic	Homo sapiens	127-139
9425735-3	1997	Here, Janusz Marcinkiewicz examines recent data indicating that chloramines, the neutrophil-specific products of the myeloperoxidase--hydrogen-peroxide--halide system, may provide a bridge between the afferent branches of the innate and acquired immune response.	Hydrogen	134-142	myeloperoxidase	Homo sapiens	117-132
9369953-2	1997	Cells that are chronically exposed to a low pH environment must adapt their hydrogen ion extrusion mechanisms to maintain their pHi in the physiologic range.	Hydrogen	76-84	glucose-6-phosphate isomerase	Cricetulus griseus	128-131
9374873-9	1997	The results, coupled with a molecular modeling study, suggest that Arg-717 of neprilysin corresponds to Arg-203 of thermolysin and that in both enzymes a hydrogen bond network exists, involving His-142, Asp-170, and Arg-203 in thermolysin and His-583, Asp-650, and Arg-717 in neprilysin, which is crucial for hydrolytic activity.	Hydrogen	154-162	membrane metalloendopeptidase	Homo sapiens	78-88
9374873-9	1997	The results, coupled with a molecular modeling study, suggest that Arg-717 of neprilysin corresponds to Arg-203 of thermolysin and that in both enzymes a hydrogen bond network exists, involving His-142, Asp-170, and Arg-203 in thermolysin and His-583, Asp-650, and Arg-717 in neprilysin, which is crucial for hydrolytic activity.	Hydrogen	154-162	membrane metalloendopeptidase	Homo sapiens	276-286
9490104-0	1997	[1H-NMR studies of the ACTH-like immunoregulatory peptides].	Hydrogen	1-3	proopiomelanocortin	Homo sapiens	23-27
9490104-1	1997	A comparative study of the conformational and dynamics properties of the ACTH-like linear peptides, sequences of which correspond to amino acid residues 11-20 of the heavy chain of human immunoglobulin G1 Eu, residues 78-85 of human pro-interleukin-1 alpha and site 10-18 of human ACTH, was performed in aqueous solution and dimethylsulfoxide by 1H-NMR spectroscopy at 400 MHz.	Hydrogen	346-348	proopiomelanocortin	Homo sapiens	73-77
9341205-0	1997	New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain.	Hydrogen	61-69	coagulation factor II, thrombin	Homo sapiens	18-26
9335525-3	1997	Nearly complete backbone 1H, 15N, and 13C resonances, and most 13Cbeta side-chain resonances have been assigned for the mutant RNase A using triple-resonance NMR data and a computer program, AUTOASSIGN, for automated analysis of resonance assignments.	Hydrogen	25-27	ribonuclease pancreatic	Bos taurus	127-134
9351809-6	1997	In addition, the structures show how an arginine residue (Arg77) of Nef interacts with Asp 100 of the so-called RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface.	Hydrogen	162-170	S100 calcium binding protein B	Homo sapiens	68-71
9351809-6	1997	In addition, the structures show how an arginine residue (Arg77) of Nef interacts with Asp 100 of the so-called RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface.	Hydrogen	162-170	S100 calcium binding protein B	Homo sapiens	239-242
9351810-8	1997	In E. coli PNP, the purine- and ribose-binding sites are generally hydrophobic, although a histidine residue from an adjacent subunit probably forms a hydrogen bond with a hydroxyl group of the sugar.	Hydrogen	151-159	purine nucleoside phosphorylase	Homo sapiens	11-14
9471120-0	1997	Assessment of cholesteryl ester transfer protein function in lipoprotein mixtures by 1H NMR spectroscopy.	Hydrogen	85-87	cholesteryl ester transfer protein	Homo sapiens	14-48
9324950-0	1997	Conformational properties of the A-state of cytochrome c studied by hydrogen/deuterium exchange and electrospray mass spectrometry.	Hydrogen	68-76	cytochrome c, somatic	Homo sapiens	44-56
9471120-3	1997	Here we present a new 1H NMR spectroscopy technique to assess the CETP function in lipoprotein mixtures.	Hydrogen	22-24	cholesteryl ester transfer protein	Homo sapiens	66-70
9305963-7	1997	The proposed PNP TS also entails a hydrogen bond between N7 and a highly conserved Asn.	Hydrogen	35-43	purine nucleoside phosphorylase	Homo sapiens	13-16
9305950-0	1997	Solution structure of the paramagnetic complex of the N-terminal domain of calmodulin with two Ce3+ ions by 1H NMR.	Hydrogen	108-110	calmodulin 1	Homo sapiens	75-85
9488135-10	1997	The side chain of Asp31 in two subunits of the TNF mutant is predicted to form hydrogen bond interactions with Ser59 or Cys70 of R1, while it has no predicted interactions with R2.	Hydrogen	79-87	tumor necrosis factor	Homo sapiens	47-50
9305964-9	1997	In an effort to alter the substrate specificity of human PNP, mutants of Asn243 and Glu201 were designed to reverse hydrogen bond donor and acceptor interactions with the purine base.	Hydrogen	116-124	purine nucleoside phosphorylase	Homo sapiens	57-60
9379452-10	1997	Alternatively, the CB2 selectivities may be a results of an amino acid change from a hydrogen bond-accepting residue in CB1 to a hydrogen bond-donating residue in CB2.	Hydrogen	85-93	cannabinoid receptor 2 (macrophage)	Mus musculus	19-22
9364740-10	1997	The involvement of these two isoforms in the O-demethylation of 4-nitroanisole can be rationalized in terms of a hydrogen bond interaction with the nitro group and the active site of CYP2A6 and a hydrophobic interaction with the active site of CYP2E1.	Hydrogen	113-121	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	244-250
9379452-10	1997	Alternatively, the CB2 selectivities may be a results of an amino acid change from a hydrogen bond-accepting residue in CB1 to a hydrogen bond-donating residue in CB2.	Hydrogen	85-93	cannabinoid receptor 2 (macrophage)	Mus musculus	163-166
9379452-10	1997	Alternatively, the CB2 selectivities may be a results of an amino acid change from a hydrogen bond-accepting residue in CB1 to a hydrogen bond-donating residue in CB2.	Hydrogen	129-137	cannabinoid receptor 2 (macrophage)	Mus musculus	19-22
9379452-10	1997	Alternatively, the CB2 selectivities may be a results of an amino acid change from a hydrogen bond-accepting residue in CB1 to a hydrogen bond-donating residue in CB2.	Hydrogen	129-137	cannabinoid receptor 2 (macrophage)	Mus musculus	163-166
9303000-1	1997	The folding of the beta-sheet protein, interleukin-1 beta, was examined at pH 5.0 and 25 degrees C using pulse-labelling hydrogen exchange and electrospray ionization mass spectrometric analysis, as well as stopped-flow circular dichroism and fluorescence spectroscopies.	Hydrogen	121-129	interleukin 1 beta	Homo sapiens	39-57
11670037-4	1997	Reduction of the rhenium(II) triflate 13 under 1 atm of hydrogen gas generates the complex fac-[Re(dien)(PPh(3))(PF(3))(dien)(H(2))](+) (fac-14).	Hydrogen	56-64	FA complementation group C	Homo sapiens	91-94
9300494-1	1997	The interactions between calcitonin gene-related peptide and FAB fragments prepared from two different high-affinity anti-CGRP monoclonal antibodies (CB3 and CD1) have been studied at physiological pH using the ability of 1H NMR to detect selectively regions of dynamic flexibility.	Hydrogen	222-224	calcitonin related polypeptide alpha	Homo sapiens	25-56
9254595-4	1997	The results were consistent with homology models of the Grb2-SH2-Shc hexapeptide complex which identified several possible hydrogen bonds between Grb2-SH2 and the phosphotyrosine and conserved asparagine(+2) side chains of the Shc hexapeptide.	Hydrogen	123-131	growth factor receptor bound protein 2	Homo sapiens	56-60
9254595-4	1997	The results were consistent with homology models of the Grb2-SH2-Shc hexapeptide complex which identified several possible hydrogen bonds between Grb2-SH2 and the phosphotyrosine and conserved asparagine(+2) side chains of the Shc hexapeptide.	Hydrogen	123-131	growth factor receptor bound protein 2	Homo sapiens	56-64
9234995-0	1997	Molecular modeling of c-erbB2 receptor dimerization: coiled-coil structure of wild and oncogenic transmembrane domains--stabilization by interhelical hydrogen bonds in the oncogenic form.	Hydrogen	150-158	erb-b2 receptor tyrosine kinase 2	Homo sapiens	22-29
11670037-4	1997	Reduction of the rhenium(II) triflate 13 under 1 atm of hydrogen gas generates the complex fac-[Re(dien)(PPh(3))(PF(3))(dien)(H(2))](+) (fac-14).	Hydrogen	56-64	FA complementation group C	Homo sapiens	137-140
11670037-4	1997	Reduction of the rhenium(II) triflate 13 under 1 atm of hydrogen gas generates the complex fac-[Re(dien)(PPh(3))(PF(3))(dien)(H(2))](+) (fac-14).	Hydrogen	126-131	FA complementation group C	Homo sapiens	91-94
11670037-4	1997	Reduction of the rhenium(II) triflate 13 under 1 atm of hydrogen gas generates the complex fac-[Re(dien)(PPh(3))(PF(3))(dien)(H(2))](+) (fac-14).	Hydrogen	126-131	FA complementation group C	Homo sapiens	137-140
9335118-1	1997	The NMR assignments of backbone 1H, 13C, and 15N resonances for calcium-bound human S100B were completed via heteronuclear multidimensional NMR spectroscopic techniques.	Hydrogen	32-34	S100 calcium binding protein B	Homo sapiens	84-89
9199804-9	1997	3) The helices in AQP1 undergo limited hydrogen/deuterium exchange and thus are not readily accessible to solvent.	Hydrogen	39-47	aquaporin 1 (Colton blood group)	Homo sapiens	18-22
9216834-4	1997	At this position, 3,4-dimethylphenyl is the best moiety for inhibiting chymase and showed high selectivity compared with chymotrypsin and cathepsin G. A 3-phenylsulfonyl moiety substituted with hydrogen-bond acceptors such as nitrile and methoxycarbonyl enhances its activity.	Hydrogen	194-202	chymase 1	Homo sapiens	71-78
9188686-8	1997	This conclusion is supported by comparisons of amide 1H/2H exchange rates which are significantly faster throughout the entire structure of [C65S, C72S] RNase A than in wt RNase A.	Hydrogen	53-55	ribonuclease pancreatic	Bos taurus	153-160
9188686-0	1997	NMR structural analysis of an analog of an intermediate formed in the rate-determining step of one pathway in the oxidative folding of bovine pancreatic ribonuclease A: automated analysis of 1H, 13C, and 15N resonance assignments for wild-type and [C65S, C72S] mutant forms.	Hydrogen	191-193	ribonuclease pancreatic	Bos taurus	153-167
9184137-6	1997	(1994) Biochemistry 33, 2151-2160], these values suggest that red and green pigments have very similar Schiff base environments, while the Schiff base group in rhodopsin is more strongly hydrogen-bonded to its protein environment.	Hydrogen	187-195	rhodopsin	Homo sapiens	160-169
9184137-10	1997	The increased hydrogen bonding of the protonated Schiff base group in rhodopsin is predicted to account for the 30 nm blue shift of its absorption maximum compared to that of the green pigment.	Hydrogen	14-22	rhodopsin	Homo sapiens	70-79
9195337-0	1997	Human nucleotide excision repair protein XPA: 1H NMR and CD solution studies of a synthetic peptide fragment corresponding to the zinc-binding domain (101-141).	Hydrogen	46-48	XPA, DNA damage recognition and repair factor	Homo sapiens	41-44
9195337-1	1997	A peptide corresponding to residues 101-141 of the human nucleotide excision repair protein XPA was synthesized with an isoleucine substituted for L138 and its solution structure studied by circular dichroism and homonuclear 1H NMR spectroscopy.	Hydrogen	225-227	XPA, DNA damage recognition and repair factor	Homo sapiens	92-95
9166767-3	1997	The solution structure of a 25-residue polypeptide corresponding to the N terminus of Nef (Nef1-25) has been investigated by 1H NMR spectroscopy.	Hydrogen	125-127	S100 calcium binding protein B	Homo sapiens	86-89
9194197-5	1997	The secondary structure of myotrophin has been determined by a combination of NOEs, NH exchange data, 3JHN alpha coupling constants, and chemical shifts of 1H alpha, 13C alpha, and 13 C beta.	Hydrogen	156-158	myotrophin	Homo sapiens	27-37
9166767-3	1997	The solution structure of a 25-residue polypeptide corresponding to the N terminus of Nef (Nef1-25) has been investigated by 1H NMR spectroscopy.	Hydrogen	125-127	S100 calcium binding protein B	Homo sapiens	91-98
9082985-2	1997	The GpA membrane-spanning alpha helices cross at an angle of -40 degrees and form a small but well-packed interface that lacks intermonomer hydrogen bonds.	Hydrogen	140-148	glycophorin A (MNS blood group)	Homo sapiens	4-7
9164865-4	1997	At the same time H2 was less effective than H9 in binding to the C-terminal peptides of calmodulin TR2C (residues 78-148) and TR3E (residues 107-148).	Hydrogen	17-19	calmodulin 1	Homo sapiens	88-98
9215577-0	1997	Trp128Tyr mutation in the N-lobe of recombinant human serum transferrin: 1H- and 15N-NMR and metal binding studies.	Hydrogen	73-75	transferrin	Homo sapiens	60-71
9150396-1	1997	The folding of lysozyme involves parallel events in which hydrogen exchange kinetics indicate the development of persistent structure at very different rates.	Hydrogen	58-66	lysozyme	Homo sapiens	15-23
9045680-6	1997	In addition, the P1 carbonyl of the ketone inhibitor is pointing into the oxyanion hole and forms a hydrogen bond with the peptidic nitrogen of Gly-122, resulting in a different state compared with the tetrahedral intermediate observed in the structure of ICE and CPP32 in complex with an aldehyde inhibitor.	Hydrogen	100-108	caspase 1	Homo sapiens	256-259
9140049-0	1997	Insulin-like growth factor I stimulates apical sodium/hydrogen exchange in human proximal tubule cells.	Hydrogen	54-62	insulin like growth factor 1	Homo sapiens	0-28
9140049-1	1997	To determine whether insulin-like growth factor I (IGF-I) stimulated apical sodium/hydrogen exchange (NHE), confluent primary human proximal tubule cells (PTC) were incubated for 48 h in serum-free media in the presence or absence of 100 ng/ml IGF-I.	Hydrogen	83-91	insulin like growth factor 1	Homo sapiens	51-56
9045680-6	1997	In addition, the P1 carbonyl of the ketone inhibitor is pointing into the oxyanion hole and forms a hydrogen bond with the peptidic nitrogen of Gly-122, resulting in a different state compared with the tetrahedral intermediate observed in the structure of ICE and CPP32 in complex with an aldehyde inhibitor.	Hydrogen	100-108	caspase 3	Homo sapiens	264-269
9065782-7	1997	These findings demonstrate that the hydrogen-bonding interaction of EP3 agonists and residue 309 in the seventh transmembrane domain of the EP3alpha receptor is sufficient for the functional activation of the EP3alpha receptor.	Hydrogen	36-44	prostaglandin E receptor 3	Homo sapiens	68-71
9119014-7	1997	The 15N and 1H resonances of the tightly bound residues of bradykinin show appreciable changes in chemical shift with respect to the free form, while the 15N and 1H linewidths indicate that the hydrodynamic behaviour of bound bradykinin is dominated by the high-molecular-mass Fab fragment.	Hydrogen	12-14	kininogen 1	Homo sapiens	59-69
9047300-7	1997	1H NMR studies showed that the peptide interacts with the aromatic residues in domains I and III of CaM.	Hydrogen	0-2	calmodulin	Nicotiana tabacum	100-103
9133623-0	1997	Hydrogen-exchange kinetics of reduced alpha-lactalbumin bound to the chaperonin GroEL.	Hydrogen	0-8	lactalbumin alpha	Homo sapiens	38-55
9132061-13	1997	However, they do show two differences of importance to peroxidase catalysis: (1) the asparagine residue linked with the active site distal histidine via hydrogen bonding is absent; (2) an N-glycosylation site is located right at the entrance to the heme channel.	Hydrogen	153-161	peroxidase	Arabidopsis thaliana	55-65
9058970-4	1997	A structural analysis by 1H- and 13C-nuclear magnetic resonance and methylation indicated that SHF contained polysaccharides consisting of -4Galp1-, -4Glcp1-, and -6Glcp1- as the major residues, and Galf1- and -6Galf1- as the minor residues.	Hydrogen	25-27	Src homology 2 domain containing F	Mus musculus	95-98
9048568-13	1997	Taken together, these results suggest that the same PGHS-2 tyrosyl radical serves as the oxidant for both cyclooxygenase and lipoxygenase catalysis and that acetylation of PGHS-2 by ASA favors arachidonate binding in an altered conformation which results in abstraction of the pro-R hydrogen from C13 and formation of 11(R)- and 15(R)-HETE.	Hydrogen	283-291	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-58
9048568-13	1997	Taken together, these results suggest that the same PGHS-2 tyrosyl radical serves as the oxidant for both cyclooxygenase and lipoxygenase catalysis and that acetylation of PGHS-2 by ASA favors arachidonate binding in an altered conformation which results in abstraction of the pro-R hydrogen from C13 and formation of 11(R)- and 15(R)-HETE.	Hydrogen	283-291	prostaglandin-endoperoxide synthase 2	Homo sapiens	172-178
9025272-4	1997	Such self-associative distant interactions are absent in solution phase, as observed from the 1H NMR spectrum (acetone-d6, TMS).	Hydrogen	94-96	PYD and CARD domain containing	Homo sapiens	123-126
9033390-1	1997	The heme propionate groups of both myoglobin (Mb) and cytochrome b5 form hydrogen bonds with nearby surface amino acids residues that are believed to stabilize the heme-protein complex.	Hydrogen	73-81	myoglobin	Equus caballus	35-44
9188848-6	1997	These results confirm previous structural data that hydrogen bonds between residues of MHC II molecules and the main chain of antigenic peptides play a major interacting role.	Hydrogen	52-60	histocompatibility-2, MHC	Mus musculus	87-93
9057846-6	1997	The specific changes in 1H-NMR chemical shifts of HMG1 box A are consistent with binding of the platinated duplex (intermediate exchange rate on the 1H-NMR time-scale) to the concave face of the protein via helices I and II and the intervening loop.	Hydrogen	24-26	high mobility group box 1 pseudogene 5	Homo sapiens	50-54
9057846-6	1997	The specific changes in 1H-NMR chemical shifts of HMG1 box A are consistent with binding of the platinated duplex (intermediate exchange rate on the 1H-NMR time-scale) to the concave face of the protein via helices I and II and the intervening loop.	Hydrogen	149-151	high mobility group box 1 pseudogene 5	Homo sapiens	50-54
9006047-7	1997	ftsA transcripts, which encode coenzyme F390 synthetase, were most abundant in cells growing with high H2 availability, consistent with coenzyme F390 synthesis signaling a high exogenous supply of reductant.	Hydrogen	103-105	coenzyme F390 synthetase	Methanothermobacter thermautotrophicus str. Delta H	31-55
9041633-0	1997	A calbindin D9k mutant containing a novel structural extension: 1H nuclear magnetic resonance studies.	Hydrogen	64-66	S100 calcium binding protein G	Homo sapiens	2-15
9003408-3	1997	However, 1H NMR spectroscopy and fluorimetry indicate that both peptides interact with CaM in the presence of Ca2+.	Hydrogen	9-11	calmodulin 1	Homo sapiens	87-90
9016333-1	1997	The natural peptide [Thr6]-bradykinin, Arg1-Pro2-Pro3-Gly4-Phe5-Thr6-Pro7-Phe8-Arg9, has been conformationally examined by molecular dynamics simulations using a two-phase box consisting of H2O and CCl4 to mimic the micellar environment utilized in the 1H-NMR studies.	Hydrogen	253-255	kininogen 1	Homo sapiens	27-37
9108691-7	1997	This channel, extending from the active site to the opposite surface of the enzyme, was first noted in the hirudin-thrombin structure and contains about 20 conserved water molecules linked together by a hydrogen bonding network that connects to the main chain of thrombin.	Hydrogen	203-211	coagulation factor II, thrombin	Homo sapiens	115-123
9108691-7	1997	This channel, extending from the active site to the opposite surface of the enzyme, was first noted in the hirudin-thrombin structure and contains about 20 conserved water molecules linked together by a hydrogen bonding network that connects to the main chain of thrombin.	Hydrogen	203-211	coagulation factor II, thrombin	Homo sapiens	263-271
9377710-0	1997	Characterization of the free energy spectrum of peptostreptococcal protein L. BACKGROUND: Native state hydrogen/deuterium exchange studies on cytochrome c and RNase H revealed the presence of excited states with partially formed native structure.	Hydrogen	103-111	cytochrome c, somatic	Homo sapiens	142-154
8942679-0	1996	Active site structure in cytochrome c peroxidase and myoglobin mutants: effects of altered hydrogen bonding to the proximal histidine.	Hydrogen	91-99	cytochrome c, somatic	Homo sapiens	25-37
9392832-2	1997	blocked close-intra-arterial infusion of VIP-induced increase in gastric mucosal blood flow (GMBF, measured by the hydrogen gas clearance), and decrease in mean arterial blood pressure while not influencing basal levels in urethane-anesthetized rats.	Hydrogen	115-123	vasoactive intestinal peptide	Rattus norvegicus	41-44
8980116-0	1996	1H NMR evidence that Glu-38 interacts with the N-terminal functional domain in interleukin-8.	Hydrogen	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
9606729-2	1997	Using 15N or 15N,13C, 60% 2H isotope labelled bradykinin, complete 1H, 13C and 15N assignments for bradykinin bound to the Fab-fragment have been obtained.	Hydrogen	67-69	kininogen 1	Homo sapiens	99-109
8978548-8	1996	Dimer formation of insulin is known to occur through hydrophobic interactions and four hydrogen bonds between the B chains.	Hydrogen	87-95	insulin	Homo sapiens	19-26
8943276-10	1996	Trp-104 in the receptor, a key residue in the hormone-receptor interaction, has an altered conformation in the low affinity site enabling a favorable hydrogen bond to be formed with Asp-116 of the hormone.	Hydrogen	150-158	nuclear receptor subfamily 4 group A member 1	Homo sapiens	46-62
8946804-9	1996	The solvent-water molecule forms two hydrogen bonds with peptide molecule involving NH of Val1 as an acceptor and another with CO of a symmetry related (1-x, y-1/2, 1/2 -z) delta Phe3 as a donor.	Hydrogen	37-45	RNA, Ro60-associated Y1	Homo sapiens	158-171
8976805-13	1996	In the whole population of patients with non-insulin-dependent diabetes mellitus, the increase in intracellular pH after exposure to angiotensin II was positively correlated with intracellular free calcium increase (r = 0.53; P &lt; 0.05), suggesting a possible role of intracellular free calcium levels in the activation of the sodium-hydrogen antiport.	Hydrogen	336-344	angiotensinogen	Homo sapiens	133-147
8942679-8	1996	Here we use site-specific mutagenesis to eliminate the strong proximal hydrogen bonding in cytochrome c peroxidase and to introduce strong proximal hydrogen bonding in myoglobin.	Hydrogen	71-79	cytochrome c, somatic	Homo sapiens	91-103
8931135-0	1996	1H NMR assignments of apo calcyclin and comparative structural analysis with calbindin D9k and S100 beta.	Hydrogen	0-2	S100 calcium binding protein A6	Homo sapiens	26-35
8939759-7	1996	The two inhibitors based on 4-aminopyridine bind in notably different ways: one forms a water-mediated hydrogen bond to the active site Ser195, the other induces a rotation of the Ser214-Trp215 peptide plane that is unprecedented in thrombin structures.	Hydrogen	103-111	coagulation factor II, thrombin	Homo sapiens	233-241
9048421-8	1996	It appears that the strong binding affinity of statherin for hydroxyapatite can be attributed primarily to the N-terminal sequence, which prefers to adopted helical conformation and provides both electrostatic and hydrogen bonding interactions, thereby inhibiting its mineralization.	Hydrogen	214-222	statherin	Homo sapiens	47-56
9048427-2	1996	Two-dimensional nuclear magnetic resonance (2D-NMR) experiments (i.e., correlated spectroscopy [COSY]) and low temperature coefficient measurements for particular NH chemical shifts suggest the presence of hydrogen bondings in both VIP (1-7, and VIP (1-11) fragments.	Hydrogen	206-214	vasoactive intestinal peptide	Homo sapiens	232-235
9048427-2	1996	Two-dimensional nuclear magnetic resonance (2D-NMR) experiments (i.e., correlated spectroscopy [COSY]) and low temperature coefficient measurements for particular NH chemical shifts suggest the presence of hydrogen bondings in both VIP (1-7, and VIP (1-11) fragments.	Hydrogen	206-214	vasoactive intestinal peptide	Homo sapiens	246-249
8931135-1	1996	The homodimeric S100 protein calcyclin has been studied in the apo state by two-dimensional 1H NMR spectroscopy.	Hydrogen	92-94	S100 calcium binding protein B	Homo sapiens	16-20
8931135-1	1996	The homodimeric S100 protein calcyclin has been studied in the apo state by two-dimensional 1H NMR spectroscopy.	Hydrogen	92-94	S100 calcium binding protein A6	Homo sapiens	29-38
8855243-2	1996	Despite containing a complex all-beta-sheet topology and eight prolines, the refolding of the 10th type III module of human fibronectin has been found to be very rapid, with native core packing, amide hydrogen bonding, and backbone conformation all recovered within 1 s at 5 degrees C. These observations indicate that this domain can overcome many structural characteristics often thought to slow the folding process.	Hydrogen	201-209	fibronectin 1	Homo sapiens	124-135
9552306-7	1996	It is hypothesized that the strength of these dried pellets may, in part, be due to the conversion of some of the intramolecular hydrogen bonded amorphous fibrils at the surface of the MCC particles to intermolecular hydrogen bonded fibrils with other MCC particles.	Hydrogen	129-137	MCC regulator of WNT signaling pathway	Homo sapiens	185-188
9552306-7	1996	It is hypothesized that the strength of these dried pellets may, in part, be due to the conversion of some of the intramolecular hydrogen bonded amorphous fibrils at the surface of the MCC particles to intermolecular hydrogen bonded fibrils with other MCC particles.	Hydrogen	129-137	MCC regulator of WNT signaling pathway	Homo sapiens	252-255
8901555-0	1996	beta-Lactamase binds to GroEL in a conformation highly protected against hydrogen/deuterium exchange.	Hydrogen	73-81	GroEL	Escherichia coli	24-29
8893838-6	1996	Compound 1h, 2-[[4-(o-methoxyphenyl)piperazin-1-yl] methyl]-1,3-dioxoperhydroimidazo [1,5-alpha]pyridine, bound at 5-HT1A sites with nanomolar affinity (Ki = 31.7 nM) and high selectivity over alpha 1, D2, and 5-HT2A receptors (Ki &gt; 1000, &gt; 10 000, and &gt; 1000 nM, respectively).	Hydrogen	9-11	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	115-121
8914271-1	1996	Essentially complete backbone and side-chain 1H, 15N and 13C resonance assignments for the 185-amino-acid cytokine interleukin-6 (IL-6) are presented.	Hydrogen	45-47	interleukin 6	Homo sapiens	115-128
8794768-4	1996	NOE, scalar coupling, secondary chemical shift, and amide proton exchange data were used to characterize the secondary structural elements and hydrogen-bonding network in the Grb2 SH2 domain.	Hydrogen	143-151	growth factor receptor bound protein 2	Homo sapiens	175-179
8805593-7	1996	The nucleotide complexes reveal a simple and elegant way for a beta hairpin to recognize specific nucleic acids: uracil is inserted into a distorted antiparallel beta hairpin and hydrogen bonds entirely to main-chain atoms.	Hydrogen	179-187	amyloid beta precursor protein	Homo sapiens	61-67
8914271-1	1996	Essentially complete backbone and side-chain 1H, 15N and 13C resonance assignments for the 185-amino-acid cytokine interleukin-6 (IL-6) are presented.	Hydrogen	45-47	interleukin 6	Homo sapiens	130-134
8752313-5	1996	The rates of formation of both hydrogen atoms and hydroxyl radicals were estimated to be equal to 25 microM min-1 in the sonolysis of pure water under argon.	Hydrogen	31-39	CD59 molecule (CD59 blood group)	Homo sapiens	108-113
8794881-5	1996	Furthermore, substitution of the 3-hydroxyl group in SPP with hydrogen decreased its ability to stimulate DNA synthesis and to stimulate AP-1 transcriptional activity.	Hydrogen	62-70	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-141
8718890-6	1996	The ability of the three SHA oxygen atoms to closely duplicate the hydrogen-bonding pattern of these three water molecules in the native enzyme is postulated to account for the strong binding of this inhibitor to MPO.	Hydrogen	67-75	myeloperoxidase	Homo sapiens	213-216
8718890-8	1996	Similarities in the hydrogen-bonding patterns of amino acid residues and water molecules in the distal heme pockets of myeloperoxidase and the nonhomologous cytochrome c peroxidase suggest that they may have similar mechanisms of compound I formation.	Hydrogen	20-28	myeloperoxidase	Homo sapiens	119-134
8718890-9	1996	A model is presented for a prereaction complex of myeloperoxidase in which hydrogen peroxide is hydrogen bonded to the distal histidine, as a prerequisite for deprotonation and subsequent binding at the sixth coordination site of the heme iron.	Hydrogen	75-83	myeloperoxidase	Homo sapiens	50-65
8757924-2	1996	Sequential assignments are presented for 1H NMR resonances of the N-terminal residues Asp1, Ala2 and His3 of human serum albumin (HSA).	Hydrogen	41-43	albumin	Homo sapiens	115-128
8756328-4	1996	The arginines help extend the influence of the phosphate group through a network of hydrogen bonds to both CDK2 and cyclinA.	Hydrogen	84-92	cyclin A2	Homo sapiens	116-123
8755709-5	1996	The terminal epoxide carbon C18 is covalently bound to the N7 atom of the central guanine, as evidenced by lability of the C8 hydrogen of this purine upon reaction with hedamycin.	Hydrogen	126-134	Bardet-Biedl syndrome 9	Homo sapiens	28-31
8688416-6	1996	Calcium binding to S100b also resulted in a shifting and broadening of several 1H resonances from the Ca-S100b form only including those from the side chains of residues F14, F70, and F73 but not those of residue Y17.	Hydrogen	79-81	S100 calcium binding protein B	Homo sapiens	19-24
8688416-6	1996	Calcium binding to S100b also resulted in a shifting and broadening of several 1H resonances from the Ca-S100b form only including those from the side chains of residues F14, F70, and F73 but not those of residue Y17.	Hydrogen	79-81	S100 calcium binding protein B	Homo sapiens	105-110
8756680-6	1996	The dependence of Nef 1H and 15N amide chemical shifts on peptide concentration indicates that the binding is in the fast chemical exchange limit, with a dissociation constant Kd of approximately 1 mM.	Hydrogen	22-24	S100 calcium binding protein B	Homo sapiens	18-21
8756691-0	1996	Conformations of human apolipoprotein E(263-286) and E(267-289) in aqueous solutions of sodium dodecyl sulfate by CD and 1H NMR.	Hydrogen	121-123	apolipoprotein E	Homo sapiens	23-39
8672464-1	1996	[1H, 13C] NMR investigations of metal-induced conformational changes in the blood serum protein transferrin (80 kDa) are reported.	Hydrogen	1-3	transferrin	Homo sapiens	96-107
8837242-8	1996	The percentage underestimation increased with increasing digestion times (1 h, 46.52 +/- 3.69%; 3 h, 77.5 +/- 7.18%; 4 h, 100%) and with increasing concentrations of Fn digest products (1h) added to normal plasma samples (n = 10) (40 micrograms, 23 +/- 8.1%; 125 micrograms, 36.33 +/- 5.1%; 250 micrograms, 43.66 +/- 6.5%).	Hydrogen	186-188	fibronectin 1	Homo sapiens	166-168
8663249-3	1996	Computational experiments with a 5-HT2A receptor model suggest that the same functional group of 5-hydroxytryptamine also forms a hydrogen bond with the side chain of Ser3.36(159), which is adjacent in space to Asp3.32(155).	Hydrogen	130-138	5-hydroxytryptamine receptor 2A	Homo sapiens	33-48
8670846-2	1996	Uracil binds in a rigid pocket at the base of the DNA-binding groove of human UDG and the specificity for uracil over the structurally related DNA bases thymine and cytosine is conferred by shape complementarity, as well as by main chain and Asn204 side chain hydrogen bonds.	Hydrogen	260-268	uracil DNA glycosylase	Homo sapiens	78-81
8673608-2	1996	Cytochrome P450eryF is unusual in having alanine in place of this threonine and an ordered active site water molecule (Wat 519) which is hydrogen bonded to the substrate 5-hydroxyl group and is in position to operate as an acid catalyst required for cleaving dioxygen.	Hydrogen	137-145	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
8683586-1	1996	A pH titration study of calbindin D9k was performed using heteronuclear 1H-13C two-dimensional NMR spectroscopy.	Hydrogen	72-74	S100 calcium binding protein G	Homo sapiens	24-37
8672464-3	1996	[1H, 13C] NMR resonance assignments are presented for all nine methionine 13CH3 groups of recombinant deglycosylated human transferrin on the basis of studies of recombinant N-lobe (40 kDa, five Met residues), NOESY-relayed [1H, 13C] HMQC spectra, and structural considerations.	Hydrogen	1-3	transferrin	Homo sapiens	123-134
8672464-3	1996	[1H, 13C] NMR resonance assignments are presented for all nine methionine 13CH3 groups of recombinant deglycosylated human transferrin on the basis of studies of recombinant N-lobe (40 kDa, five Met residues), NOESY-relayed [1H, 13C] HMQC spectra, and structural considerations.	Hydrogen	225-227	transferrin	Homo sapiens	123-134
8679526-19	1996	As in the ecDHFR dideazatetrahydrofolate complex, in both the P6(1) and P6(5) structures a water molecule bridges pteridine O4 and Trp-22(N epsilon 1) with ideal geometry for hydrogen bonding, perhaps contributing to the slow release of 5,6,7,8-tetrahydrofolate from the enzyme-product complex.	Hydrogen	175-183	dihydrofolate reductase	Escherichia coli	10-16
8664326-0	1996	Conformation of human serum apolipoprotein A-I(166-185) in the presence of sodium dodecyl sulfate or dodecylphosphocholine by 1H-NMR and CD.	Hydrogen	126-128	apolipoprotein A1	Homo sapiens	28-46
8928891-4	1996	HS inhibited plasma guanosine 3",5"-cyclic monophosphate (cGMP) levels, a biological market of endogenous ANP activity, in a dose-dependent manner from 21.8 +/- 2.2 to 7.2 +/- 1.4 pmol/ml (P &lt; 0.001), with concomitant significant increases in plasma ET-1 levels from 4.54 +/- 0.60 to 6.60 +/- 0.72 pg/ml (P &lt; 0.05).	Hydrogen	0-2	endothelin 1	Canis lupus familiaris	253-257
8652791-6	1996	In CD3CN solution, the conformer with a ci5 peptide bond is quite similar to that observed in the solid state, while the conformer containing all trans peptide bonds is characterized by an intramolecular hydrogen bond stabilizing a C10- and a C13-ring structure.	Hydrogen	204-212	homeobox C10	Homo sapiens	232-235
8681966-5	1996	1H-NMR spectra of rPsA contained features consistent with a high degree of beta-sheet in the N-terminal globular domain, a feature commonly observed in cell-adhesion proteins.	Hydrogen	0-2	aminopeptidase puromycin sensitive	Rattus norvegicus	18-22
8744012-5	1996	Moreover, 1H NMR signal intensities of N-acetyl groups and acetate strongly correlate with the myeloperoxidase activities in synovial fluids from patients with rheumatoid arthritis.	Hydrogen	10-12	myeloperoxidase	Homo sapiens	95-110
8792434-0	1996	Determination of molecular mobility of lyophilized bovine serum albumin and gamma-globulin by solid-state 1H NMR and relation to aggregation-susceptibility.	Hydrogen	106-108	albumin	Homo sapiens	58-71
8636987-5	1996	The activation enthalpies for hydrogen exchange for 36 of the 126 amide hydrogens in lysozyme and for 25 of 126 lysozyme amide hydrogens in the lysozyme-D1.3 complex are also reported.	Hydrogen	127-136	lysozyme like 1	Homo sapiens	144-155
8636987-5	1996	The activation enthalpies for hydrogen exchange for 36 of the 126 amide hydrogens in lysozyme and for 25 of 126 lysozyme amide hydrogens in the lysozyme-D1.3 complex are also reported.	Hydrogen	30-38	lysozyme like 1	Homo sapiens	144-155
8785495-0	1996	1H, 15N and 13C resonance assignments and monomeric structure of the amino-terminal extracellular domain of epithelial cadherin.	Hydrogen	0-2	cadherin 1	Homo sapiens	108-127
8613983-1	1996	1H-NMR studies of the 36 kDa R6 insulin hexamer.	Hydrogen	0-2	insulin	Homo sapiens	32-39
8613983-2	1996	The structure and dynamics of the R6 human insulin hexamer are investigated by two- and three-dimensional homonuclear 1H-NMR spectroscopy.	Hydrogen	118-120	insulin	Homo sapiens	43-50
8632468-2	1996	The D3 base has been previously shown to specifically recognize T-A and C-G base-pairs via intercalation on the 3" side (with respect to the purine strand) of the target base pair, instead of forming sequence-specific hydrogen bonds.	Hydrogen	218-226	iodothyronine deiodinase 3	Homo sapiens	4-6
8632468-3	1996	1H resonance assignments have been made for the D3 base and most of the non-loop portion of the triplex.	Hydrogen	0-2	iodothyronine deiodinase 3	Homo sapiens	48-50
8636987-5	1996	The activation enthalpies for hydrogen exchange for 36 of the 126 amide hydrogens in lysozyme and for 25 of 126 lysozyme amide hydrogens in the lysozyme-D1.3 complex are also reported.	Hydrogen	72-81	lysozyme like 1	Homo sapiens	144-155
8620875-0	1996	Hydrogen exchange in the carbon monoxide complex of soybean leghemoglobin.	Hydrogen	0-8	leghemoglobin A	Glycine max	60-73
8620875-1	1996	Hydrogen/deuterium exchange rates for individual amide protons have been measured for the carbon monoxide complex of soybean leghemoglobin.	Hydrogen	0-8	leghemoglobin A	Glycine max	125-138
11536750-1	1996	The reaction of iron sulfide (FeS) with H2S in water, in presence of CO2 under anaerobic conditions was found to yield H2 and a variety of organic sulfur compounds, mainly thiols and small amounts of CS2 and dimethyldisulfide.	Hydrogen	40-42	chorionic somatomammotropin hormone 2	Homo sapiens	200-203
8704108-1	1996	This study was designed to assess whether contrast-enhanced dynamic 1H magnetic resonance imaging (DMRI) can be used to detect the effects of the loop diuretic furosemide and the vasoactive peptide angiotensin II on tubular water reabsorption in the rat kidney.	Hydrogen	68-70	angiotensinogen	Rattus norvegicus	198-212
8845763-5	1996	The beta 1 strand is parallel to the beta 2 strand of the same subunit on the basis of cross stand NH(i)-NH(j) NOEs in a 2D 15N-edited 1H-NOESY spectrum of hexameric 4-OT containing two 15N-labeled subunits/hexamer.	Hydrogen	135-137	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	4-10
8603258-0	1996	Characterization of conformation and dynamics of CD4 Fragment (81-92) TYICEVEDQKEE and its benzylated derivative by 1H NMR spectroscopy and molecular modeling: Relevance of conformation to biological function.	Hydrogen	116-118	CD4 molecule	Homo sapiens	49-52
8652571-0	1996	Salt effects on the amide hydrogen exchange of bovine pancreatic trypsin inhibitor.	Hydrogen	26-34	trophoblast Kunitz domain protein 1	Bos taurus	65-82
8603258-1	1996	Two-dimensional 1H nuclear magnetic resonance (NMR) spectroscopy experiments were carried out to determine the conformation of a CD4 fragment (81-92) TYICEVEDQKEE and its di-benzylated analogue in aqueous solution.	Hydrogen	16-18	CD4 molecule	Homo sapiens	129-132
8605627-0	1996	Strong hydrogen bonding interactions involving a buried glutamic acid in the transmembrane sequence of the neu/erbB-2 receptor.	Hydrogen	7-15	erb-b2 receptor tyrosine kinase 2	Homo sapiens	107-110
8605627-0	1996	Strong hydrogen bonding interactions involving a buried glutamic acid in the transmembrane sequence of the neu/erbB-2 receptor.	Hydrogen	7-15	erb-b2 receptor tyrosine kinase 2	Homo sapiens	111-117
8652550-8	1996	The hydrogen bond with the N delta 2 moiety of Asn 18 appears to be the most conserved interaction, being similar to those observed for sulfate ion bound to human basic FGF (bFGF) and similar but not identical to interactions observed for bovine aFGF with heparin analogs.	Hydrogen	4-12	fibroblast growth factor 2	Homo sapiens	163-172
8617199-6	1996	Based on these studies, we propose a binding site model for the endogenous peptide ligand in the galanin receptor where the N-terminus of galanin hydrogen bonds with Glu271 of the receptor, Trp2 of galanin interacts with the Zn2+ sensitive pair of His264 and His267 of transmembrane domain VI, and Tyr9 of galanin interacts with Phe282 of transmembrane domain VII, while the C-terminus of galanin is pointing towards the N-terminus of th	Hydrogen	146-154	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	190-194
8652550-8	1996	The hydrogen bond with the N delta 2 moiety of Asn 18 appears to be the most conserved interaction, being similar to those observed for sulfate ion bound to human basic FGF (bFGF) and similar but not identical to interactions observed for bovine aFGF with heparin analogs.	Hydrogen	4-12	fibroblast growth factor 2	Homo sapiens	174-178
8615376-1	1996	A number of oligonucleotides were designed to bind through Hoogsteen triple helix or Watson-Crick hydrogen bonds to the p53 consensus sequence homology localized within the human nontranscribed rRNA spacer region.	Hydrogen	98-106	tumor protein p53	Homo sapiens	120-123
8932447-7	1996	RESULTS: We observe that the relative intensity of the SOD bands from 28 degrees C to 77 degrees C show graduate loss of beta-sheet "distorted" structure, loss of turns, and existence of an intermediate state around 50 degrees C. Beginning at 80 degrees C, changes are obtained in three temperature regions: (i) 80 degrees C, (ii) 92 degrees C, (iii) 109 degrees C. The result suggests that SOD folding/unfolding transition involves mostly the relative changes within the regions of helix-like hydrogen bonding pattern, turn, twisted beta-bend and irregular structures.	Hydrogen	494-502	superoxide dismutase 1	Homo sapiens	55-58
8697700-0	1996	Characteristics of the sodium/hydrogen exchange in non-insulin-dependent diabetic patients with microalbuminuria and hypertension.	Hydrogen	30-38	insulin	Homo sapiens	55-62
7493938-0	1995	Fourier transform infrared and hydrogen/deuterium exchange reveal an exchange-resistant core of alpha-helical peptide hydrogens in the nicotinic acetylcholine receptor.	Hydrogen	31-39	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	135-167
7503727-1	1995	Acute TPA treatment (1h, 100nM) of a human pancreatic carcinoid cell line (BON) depletes cell contents of chromogranin A (CGA) and pancreastatin (PST), a peptide derived posttranslationally from CGA.	Hydrogen	21-23	chromogranin A	Homo sapiens	106-120
7503727-1	1995	Acute TPA treatment (1h, 100nM) of a human pancreatic carcinoid cell line (BON) depletes cell contents of chromogranin A (CGA) and pancreastatin (PST), a peptide derived posttranslationally from CGA.	Hydrogen	21-23	chromogranin A	Homo sapiens	122-125
7493938-0	1995	Fourier transform infrared and hydrogen/deuterium exchange reveal an exchange-resistant core of alpha-helical peptide hydrogens in the nicotinic acetylcholine receptor.	Hydrogen	118-127	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	135-167
7493938-1	1995	The structure of the nicotinic acetylcholine receptor (nAChR) has been studied using a novel combination of hydrogen/deuterium exchange and attenuated total reflectance Fourier transform infrared spectroscopy.	Hydrogen	108-116	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	21-53
7493938-1	1995	The structure of the nicotinic acetylcholine receptor (nAChR) has been studied using a novel combination of hydrogen/deuterium exchange and attenuated total reflectance Fourier transform infrared spectroscopy.	Hydrogen	108-116	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	55-60
7493938-4	1995	The 30% of peptide hydrogens that exchange within seconds is highly exposed to solvent and likely involved in random and turn conformations, whereas the 25% of exchange-resistant peptide hydrogens is relatively inaccessible to solvent and likely located in the transmembrane domains of the nAChR.	Hydrogen	187-196	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	290-295
7578128-6	1995	However, in the absence of both cholesterol and anionic lipids, there is a slightly enhanced rate of exchange of alpha-helical peptide hydrogens for deuterium that occurs as a result of either an increase in nAChR dynamics or an increase in the accessibility of transmembrane peptide hydrogens to 2H2O.	Hydrogen	135-144	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	208-213
7499290-1	1995	A series of modified nucleotides was used to map the hydrogen-bonding and hydrophobic sites of the TerB DNA required for Tus interaction.	Hydrogen	53-61	DNA replication terminus site-binding protein	Escherichia coli	121-124
7473740-0	1995	Different subdomains are most protected from hydrogen exchange in the molten globule and native states of human alpha-lactalbumin.	Hydrogen	45-53	lactalbumin alpha	Homo sapiens	112-129
7578128-0	1995	Structure of both the ligand- and lipid-dependent channel-inactive states of the nicotinic acetylcholine receptor probed by FTIR spectroscopy and hydrogen exchange.	Hydrogen	146-154	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	81-113
8521850-4	1995	From a consideration of the NOE intensities, 3J(NH-alpha CH) coupling constants, 1H and 13C chemical shifts of backbone atoms and amide-proton exchange rates, the pNR-2/pS2 was found to contain two short antiparallel beta-strands (32-35 and 43-46), a short helix (25-30) and a type I beta-turn (11-15).	Hydrogen	81-83	trefoil factor 1	Homo sapiens	163-168
8521850-4	1995	From a consideration of the NOE intensities, 3J(NH-alpha CH) coupling constants, 1H and 13C chemical shifts of backbone atoms and amide-proton exchange rates, the pNR-2/pS2 was found to contain two short antiparallel beta-strands (32-35 and 43-46), a short helix (25-30) and a type I beta-turn (11-15).	Hydrogen	81-83	trefoil factor 1	Homo sapiens	169-172
8521850-6	1995	Similar 1H chemical shifts were noted for several conserved residues in pNR-2/pS2 and pSP and a characteristic Phe residue with a slowly flipping ring was found in the pNR-2/pS2 variant and in both domains of pSP.	Hydrogen	8-10	trefoil factor 1	Homo sapiens	72-77
8521850-6	1995	Similar 1H chemical shifts were noted for several conserved residues in pNR-2/pS2 and pSP and a characteristic Phe residue with a slowly flipping ring was found in the pNR-2/pS2 variant and in both domains of pSP.	Hydrogen	8-10	trefoil factor 1	Homo sapiens	78-81
8521850-8	1995	Correlation time measurements derived from 1H-1H NOE measurements indicate that the Cys58--&gt;Ser form of the pNR-2/pS2 protein used in this study is monomeric in solution at approximately 2 mM.	Hydrogen	43-45	trefoil factor 1	Homo sapiens	111-116
8521850-8	1995	Correlation time measurements derived from 1H-1H NOE measurements indicate that the Cys58--&gt;Ser form of the pNR-2/pS2 protein used in this study is monomeric in solution at approximately 2 mM.	Hydrogen	46-48	trefoil factor 1	Homo sapiens	111-116
8567184-9	1995	The backbone-modified insulin derivative [SarB26]des-(B27-B30)-insulin-B26-amide (sarcosine = N-methylglycine) exhibits an unexpectedly high receptor affinity of 1100% which demonstrates that the B26-amide hydrogen of the native hormone is not important for receptor binding.	Hydrogen	206-214	insulin	Homo sapiens	22-29
8567184-9	1995	The backbone-modified insulin derivative [SarB26]des-(B27-B30)-insulin-B26-amide (sarcosine = N-methylglycine) exhibits an unexpectedly high receptor affinity of 1100% which demonstrates that the B26-amide hydrogen of the native hormone is not important for receptor binding.	Hydrogen	206-214	insulin	Homo sapiens	63-70
7577910-0	1995	Measuring the strength of side-chain hydrogen bonds in peptide helices: the Gln.Asp (i, i + 4) interaction.	Hydrogen	37-45	PPP1R2C family member C	Homo sapiens	88-93
8563635-1	1995	The binding of calmodulin (CaM) to four synthetic peptide analogues of the skeletal muscle myosin light chain kinase (sk-MLCK) target sequence has been studied using 1H-NMR.	Hydrogen	166-168	calmodulin 1	Homo sapiens	15-25
8563635-1	1995	The binding of calmodulin (CaM) to four synthetic peptide analogues of the skeletal muscle myosin light chain kinase (sk-MLCK) target sequence has been studied using 1H-NMR.	Hydrogen	166-168	calmodulin 1	Homo sapiens	27-30
8563635-4	1995	1H-NMR spectroscopy indicates that the WF10 peptide interacts specifically with the C-domain of CaM, and the chemical shifts of the bound Trp side chain are very similar in the CaM:WF10 and CaM:WFF complexes.	Hydrogen	0-2	calmodulin 1	Homo sapiens	96-99
8590305-2	1995	CC8.1h constitutively produces IFN activity that shares physiochemical properties with mammalian IFN-gamma.	Hydrogen	4-6	interferon alpha 1	Homo sapiens	31-34
8590305-2	1995	CC8.1h constitutively produces IFN activity that shares physiochemical properties with mammalian IFN-gamma.	Hydrogen	4-6	interferon gamma	Homo sapiens	97-106
7577919-3	1995	All 10 1H-13C correlations in the heteronuclear single- and multiple-quantum coherence (HSMQC) spectrum of [13C-methyl] Met cTnC in the complex with cTnI(33-211) were previously assigned [Krudy, G. A., Kleerekoper, Q., Guo, X., Howarth, J. W., Solaro, R. J., &amp; Rosevear, P. R. (1994) J. Biol.	Hydrogen	7-9	troponin C1, slow skeletal and cardiac type	Homo sapiens	124-128
7577910-3	1995	Results are given for the glutamine--aspartate (i, i + 4) hydrogen-bond interaction.	Hydrogen	58-66	PPP1R2C family member C	Homo sapiens	26-56
7577919-6	1995	In the presence of oxidized spin label, nine of the 10 Met methyl 1H-13C correlations of cTnC were significantly broadened in the cTnC(C35S) monomer.	Hydrogen	66-68	troponin C1, slow skeletal and cardiac type	Homo sapiens	89-93
7577919-6	1995	In the presence of oxidized spin label, nine of the 10 Met methyl 1H-13C correlations of cTnC were significantly broadened in the cTnC(C35S) monomer.	Hydrogen	66-68	troponin C1, slow skeletal and cardiac type	Homo sapiens	130-134
8846686-6	1995	The areas under the curve (AUC) of free insulin concentration were smaller for group 2 (p = 0.01) than for group 1 (212.2 +/- 22.0 vs 316.8 +/- 25.3 mU l-1h).	Hydrogen	154-156	insulin	Homo sapiens	40-47
7487905-11	1995	Finally, the IC50 values for thiorphan and substituted thiorphans strongly suggest that Asn542 of neprilysin binds the substrate on the amino side of the P2" residue by formation of a unique hydrogen bond.	Hydrogen	191-199	membrane metalloendopeptidase	Homo sapiens	98-108
7588813-0	1995	A Fourier-transform infrared spectroscopic investigation of the hydrogen-deuterium exchange and secondary structure of the 28-kDa channel-forming integral membrane protein (CHIP28).	Hydrogen	64-72	aquaporin 1 (Colton blood group)	Homo sapiens	173-179
7588813-10	1995	This high hydrogen-deuterium exchange observed with the CHIP28 protein is consistent with the presence of an aqueous pore within the protein structure.	Hydrogen	10-18	aquaporin 1 (Colton blood group)	Homo sapiens	56-62
7666423-1	1995	The three-dimensional solution structure of (Cd2+)1-calbindin D9k has been determined by distance geometry, restrained molecular dynamics and relaxation matrix calculations using experimental constraints obtained from two-dimensional 1H and 15N-1H NMR spectroscopy.	Hydrogen	234-236	S100 calcium binding protein G	Homo sapiens	52-65
7574675-6	1995	Comparison of the specificity pocket of the APPA complexes of thrombin and trypsin reveals differences in hydrogen bonding and shows for the first time that the S1 site of thrombin is larger than that of trypsin and as a result thrombin may be able to accommodate a bulkier P1 group than trypsin.	Hydrogen	106-114	coagulation factor II, thrombin	Homo sapiens	62-70
7552698-1	1995	In cytochrome c, the unfolding reaction occurs in four discreet stops, as monitored by the exchange of solvent hydrogen for backbone aminde hydrogens under varying denaturant concentrations.	Hydrogen	111-119	cytochrome c, somatic	Homo sapiens	3-15
7563054-0	1995	A residue to residue hydrogen bond mediates the nucleotide specificity of ribonuclease A.	Hydrogen	21-29	ribonuclease pancreatic	Bos taurus	74-88
7666423-1	1995	The three-dimensional solution structure of (Cd2+)1-calbindin D9k has been determined by distance geometry, restrained molecular dynamics and relaxation matrix calculations using experimental constraints obtained from two-dimensional 1H and 15N-1H NMR spectroscopy.	Hydrogen	245-247	S100 calcium binding protein G	Homo sapiens	52-65
7669785-2	1995	In aldose reductase, the active site residue Tyr48 is the proton donor in a hydrogen-bonding network involving residues Asp43/Lys77, while His110 directs the orientation of substrates in the active site pocket.	Hydrogen	76-84	aldo-keto reductase family 1 member B	Homo sapiens	3-19
7556201-5	1995	1H-NMR studies of rabbit osteocalcin gave a set of resonance assignments and NOEs which could be interpreted in terms of distance constraints.	Hydrogen	0-2	osteocalcin	Oryctolagus cuniculus	25-36
7486814-2	1995	Using fluorescent dyes 2",7"-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF) and Fura-2 AM, changes was evaluated in the concentration of baseline and thrombin-stimulated increases in intracellular ionized calcium (Ca2+i) relative to hydrogen ions in the platelets from control, insulin-treated, and non-treated diabetic rats.	Hydrogen	236-244	coagulation factor II	Rattus norvegicus	153-161
8564420-0	1995	Solution structure of endothelin B receptor selective antagonist RES-701-1 determined by 1H NMR spectroscopy.	Hydrogen	89-91	endothelin receptor type B	Homo sapiens	22-43
8564420-1	1995	The three-dimensional structure of the endothelin B receptor (ETB) selective antagonist RES-701-1 has been determined by 1H NMR in deuterated dimethyl sulphoxide.	Hydrogen	121-123	endothelin receptor type B	Homo sapiens	39-60
8564420-1	1995	The three-dimensional structure of the endothelin B receptor (ETB) selective antagonist RES-701-1 has been determined by 1H NMR in deuterated dimethyl sulphoxide.	Hydrogen	121-123	endothelin receptor type B	Homo sapiens	62-65
8556358-2	1995	The peroxidase reaction of catalase requires substrates for hydrogen donation, other than H2O2, e.g. alcohols, aldehydes, formic acid.	Hydrogen	60-68	catalase	Homo sapiens	27-35
7654722-0	1995	Discontinuous equilibrium titrations of cooperative calcium binding to calmodulin monitored by 1-D 1H-nuclear magnetic resonance spectroscopy.	Hydrogen	99-101	calmodulin 1	Homo sapiens	71-81
7657098-5	1995	RESULTS: Perfusion of the antral sleeve lumen with media of increasing hydrogen ion concentration caused pH-dependent increases in CGRP and somatostatin release and decrease in gastrin release.	Hydrogen	71-79	somatostatin	Rattus norvegicus	140-152
8693488-12	1995	HS inhibited the natriuresis mediated by IL-1 beta, despite increases in plasma ANP and had no influence on plasma AVP and MABP.	Hydrogen	0-2	interleukin 1 beta	Rattus norvegicus	41-50
8535286-1	1995	Two synthetic peptides corresponding to N-terminal fragments of human and chicken transthyretin have been synthesized and their structures examined in solution using 1H NMR spectroscopy.	Hydrogen	166-168	transthyretin	Gallus gallus	82-95
7484029-9	1995	P50 for oxygen (3.6 and 3.6 kPa) and 2,3-DPG concentrations (5.3 and 5.1 mikromol/ml erythrocyte) in shed mediastinal blood (1h and 6h postoperatively) were not significantly different compared to patient-blood.	Hydrogen	125-127	nuclear factor kappa B subunit 1	Homo sapiens	0-3
8527706-3	1995	The mRNA coding for H/K ATPase and carbonic anhydrase II (CA II), the two enzymes responsible for the generation of hydrogen ions from the parietal cell, were also quantitated.	Hydrogen	116-124	carbonic anhydrase 2	Rattus norvegicus	58-63
7623386-0	1995	Local perturbations by ligand binding of hydrogen deuterium exchange kinetics in a four-helix bundle protein, acyl coenzyme A binding protein (ACBP).	Hydrogen	41-49	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	110-141
7623386-0	1995	Local perturbations by ligand binding of hydrogen deuterium exchange kinetics in a four-helix bundle protein, acyl coenzyme A binding protein (ACBP).	Hydrogen	41-49	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	143-147
7623386-1	1995	Amide hydrogen exchange kinetics of the individual amides in a four-helix bundle protein, acyl-coenzyme A binding protein, have been studied by nuclear magnetic resonance spectroscopy.	Hydrogen	6-14	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	90-121
7623386-6	1995	The results suggest that hydrogen exchange kinetics in the individual sites of acyl-coenzyme A binding protein are primarily determined by local structural features; they show that ligand binding gives rise mainly to changes localized at the sites of interaction between protein and ligand; they imply that the perturbation of exchange kinetics caused by ligation can be either, as in one example a local stabilisation of the pre-exchange equilibrium induced by formation of a hydrogen bond, or as seen here in several examples a reduction of the dynamic processes that lead to the opening and closing processes of the pre-exchange equilibrium.	Hydrogen	25-33	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	79-110
7623386-6	1995	The results suggest that hydrogen exchange kinetics in the individual sites of acyl-coenzyme A binding protein are primarily determined by local structural features; they show that ligand binding gives rise mainly to changes localized at the sites of interaction between protein and ligand; they imply that the perturbation of exchange kinetics caused by ligation can be either, as in one example a local stabilisation of the pre-exchange equilibrium induced by formation of a hydrogen bond, or as seen here in several examples a reduction of the dynamic processes that lead to the opening and closing processes of the pre-exchange equilibrium.	Hydrogen	477-485	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	79-110
7599122-2	1995	It was found that the average geometry of D-xylose in the active site of wild-type aldose reductase is characterized by strong hydrogen bonds involving the reactive carbonyl oxygen of the substrate and both Tyr48 and His110.	Hydrogen	127-135	aldo-keto reductase family 1 member B	Homo sapiens	83-99
7479707-0	1995	Phe-46(CD4) orients the distal histidine for hydrogen bonding to bound ligands in sperm whale myoglobin.	Hydrogen	45-53	T-cell surface glycoprotein CD4	Physeter catodon	7-10
7618079-1	1995	The hydrogen exchange behavior of native cytochrome c in low concentrations of denaturant reveals a sequence of metastable, partially unfolded forms that occupy free energy levels reaching up to the fully unfolded state.	Hydrogen	4-12	cytochrome c, somatic	Homo sapiens	41-53
7618079-4	1995	The partially unfolded forms detected by hydrogen exchange appear to represent the major intermediates in the reversible, dynamic unfolding reactions that occur even at native conditions and thus may define the major pathway for cytochrome c folding.	Hydrogen	41-49	cytochrome c, somatic	Homo sapiens	229-241
7775460-14	1995	A molecular model based on the structure of rhodopsin, in which the 5"-NH in NECA is hydrogen bonded to Ser-277 and His-278, was developed in order to visualize the environment of the ligand binding site.	Hydrogen	85-93	rhodopsin	Homo sapiens	44-53
8527874-4	1995	The structure of hCGRP is characterized by a rigid N-terminal disulfide-bonded loop followed by helix segments (Val8-Leu16), a gamma-turn (Ser19-Gly21) and several local hydrogen-bonded patterns.	Hydrogen	170-178	calcitonin related polypeptide alpha	Homo sapiens	17-22
7599173-1	1995	The effects of solvent, pH and temperature on the 1H-NMR spectra of recombinant murine interleukin-6 (IL-6) are described.	Hydrogen	50-52	interleukin 6	Mus musculus	87-100
7599173-1	1995	The effects of solvent, pH and temperature on the 1H-NMR spectra of recombinant murine interleukin-6 (IL-6) are described.	Hydrogen	50-52	interleukin 6	Mus musculus	102-106
7772042-7	1995	Thus it is likely that hydrogen-bonding of the enzyme to substituents containing oxygen or nitrogen increases the binding affinity of the hydrazides and enhances their oxidation by myeloperoxidase.	Hydrogen	23-31	myeloperoxidase	Homo sapiens	181-196
7870042-6	1995	The PDE4 and PDE3 both interact with cAMP through the 6-amino group, which most likely serves as a hydrogen bond donor.	Hydrogen	99-107	phosphodiesterase 4A	Homo sapiens	4-8
7737980-1	1995	Several mammalian livers contain monomeric 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) with A-stereospecificity in hydrogen transfer, which differs from the B-specific dimeric enzyme of human placenta in its ability to catalyze the oxidoreduction of xenobiotic trans-dihydrodiols of aromatic hydrocarbons and carbonyl compounds.	Hydrogen	68-76	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	81-92
7737737-7	1995	In contrast with microalbuminuria, sodium-hydrogen exchange covaried only with high-density lipoprotein cholesterol and insulin levels.	Hydrogen	42-50	insulin	Homo sapiens	120-127
7711039-0	1995	1H NMR of A beta amyloid peptide congeners in water solution.	Hydrogen	0-2	amyloid beta precursor protein	Homo sapiens	10-16
7744066-5	1995	1H-NMR studies show that both ligands bind with 1:1 stoichiometry to the embedded 5"-AAT site, and induce numerous shifts of NMR resonances of DNA protons located in the minor groove.	Hydrogen	0-2	serpin family A member 1	Homo sapiens	85-88
7873554-6	1995	A hitherto unobserved water molecule is hydrogen bonded to the pteridine N5 and O4 in both molecules of the asymmetric unit of the folate complex (but not the 5dfol or ddTHF complexes), supporting the hypothesis that N5 protonation of bound substrate, an important step of the DHFR reaction, occurs by way of such a water molecule.	Hydrogen	40-48	dihydrofolate reductase	Escherichia coli	277-281
7873581-1	1995	Analysis of the three dimensional structure of the class A beta-lactamases shows that Arg-244, a spatially conserved residue important for inactivation by clavulanic acid, is held in place by a hydrogen (H) bond from the residue at 276.	Hydrogen	194-202	amyloid beta precursor protein	Homo sapiens	57-63
7873586-7	1995	Proton nuclear magnetic resonance (1H-NMR) study revealed that rMIF was less thermostable (the denaturing temperature was from 50-60 degrees C) than human MIF (the denaturing temperature is about 80 degrees C (Nishihira et al.	Hydrogen	35-37	macrophage migration inhibitory factor	Rattus norvegicus	63-67
7873586-13	1995	The secondary structure of rMIF evaluated by 1H-NMR experiments revealed that the contents of alpha-helix, beta-strand, and coil were 13.8%, 55.6%, and 30.6%, respectively.	Hydrogen	45-47	macrophage migration inhibitory factor	Rattus norvegicus	27-31
7864183-3	1995	CGRP activity was evaluated by measuring local blood flow in neuromas using hydrogen polarography and laser-Doppler flowmetry.	Hydrogen	76-84	calcitonin related polypeptide alpha	Homo sapiens	0-4
7766681-1	1995	The kinetics of the thioltransferase-catalyzed symmetrical glutathione/glutathione disulfide (GSH/GSSG) interchange reaction have been studied by 1H-nuclear magnetic resonance spectroscopy.	Hydrogen	146-148	glutaredoxin-1	Sus scrofa	20-36
7752246-3	1995	Docking of the proline-rich peptide, 3BP1 on Grb2-N SH3, shows that the polyproline type II helix can bind the SH3 domain forming conserved hydrogen bonds between the main-chain carbonyl oxygens of Met4 and Pro7 of the proline-rich peptide and the reoriented side-chains of Trp36 and Asn51, respectively, and a hydrogen bond between the main-chain carbonyl of Leu8 of the proline rich peptide with the side-chain OH of Tyr52 of the Grb2-N SH3.	Hydrogen	140-148	growth factor receptor bound protein 2	Homo sapiens	45-49
7752246-3	1995	Docking of the proline-rich peptide, 3BP1 on Grb2-N SH3, shows that the polyproline type II helix can bind the SH3 domain forming conserved hydrogen bonds between the main-chain carbonyl oxygens of Met4 and Pro7 of the proline-rich peptide and the reoriented side-chains of Trp36 and Asn51, respectively, and a hydrogen bond between the main-chain carbonyl of Leu8 of the proline rich peptide with the side-chain OH of Tyr52 of the Grb2-N SH3.	Hydrogen	311-319	growth factor receptor bound protein 2	Homo sapiens	45-49
7644128-1	1995	The effect of endothelins (ETs) on sodium/hydrogen (Na+/H+) antiport system was examined in cultured rat brain capillary endothelium (RBEC).	Hydrogen	42-50	endothelin 1	Rattus norvegicus	14-25
7663341-1	1995	The backbone dynamics of the tetrameric p53 oligomerization domain (residues 319-360) have been investigated by two-dimensional inverse detected heteronuclear 1H-15N NMR spectroscopy at 500 and 600 MHz.	Hydrogen	159-161	tumor protein p53	Homo sapiens	40-43
7718556-0	1995	[Lys(-2)-Arg(-1)]endothelin-1 solution structure by two-dimensional 1H-NMR: possible involvement of electrostatic interactions in native disulfide bridge formation and in biological activity decrease.	Hydrogen	68-70	endothelin 1	Homo sapiens	17-29
7729428-4	1995	Here we describe the solution structure of the PML RING finger as solved by 1H NMR methods at physiological pH with r.m.s.	Hydrogen	76-78	promyelocytic leukemia	Mus musculus	47-50
7763134-6	1995	Everted membrane vesicles catalyzed hydrogen-dependent glyoxylate reduction to glycolate [86-207 nmol min-1 (mg protein)-1] coupled to ATP synthesis from ADP and Pi [38-82 nmol min-1 (mg protein)-1)].	Hydrogen	36-44	CD59 molecule (CD59 blood group)	Homo sapiens	102-122
7763134-6	1995	Everted membrane vesicles catalyzed hydrogen-dependent glyoxylate reduction to glycolate [86-207 nmol min-1 (mg protein)-1] coupled to ATP synthesis from ADP and Pi [38-82 nmol min-1 (mg protein)-1)].	Hydrogen	36-44	CD59 molecule (CD59 blood group)	Homo sapiens	177-197
8581429-3	1995	For compounds 1-4, an intramolecular hydrogen bond involving a 15-membered ring similar to that observed for PGE2, PGD2, and PGF2 alpha was found between the carboxyl and 15-carbonyl groups.	Hydrogen	37-45	prostaglandin D2 synthase	Homo sapiens	115-119
7697717-3	1995	In the UDG-6-aminouracil complex, uracil binds at the base of the groove within a rigid preformed pocket that confers selectivity for uracil over other bases by shape complementary and by main chain and Asn-204 side chain hydrogen bonds.	Hydrogen	222-230	uracil DNA glycosylase	Homo sapiens	7-10
7893684-1	1995	Amide hydrogen exchange has been used to examine the structural dynamics and energetics of the interaction of a peptide corresponding to the calmodulin binding domain of smooth muscle myosin light chain kinase with calcium-saturated calmodulin.	Hydrogen	6-14	calmodulin 1	Homo sapiens	141-151
7893684-1	1995	Amide hydrogen exchange has been used to examine the structural dynamics and energetics of the interaction of a peptide corresponding to the calmodulin binding domain of smooth muscle myosin light chain kinase with calcium-saturated calmodulin.	Hydrogen	6-14	calmodulin 1	Homo sapiens	233-243
7893684-7	1995	However, the slowing factors of the first hydrogen-bonded amide hydrogens are large, indicating the requirement for a reorganization of the calmodulin-peptide complex before the helix-coil transitions leading to exchange can occur.	Hydrogen	42-50	calmodulin 1	Homo sapiens	140-150
7893684-7	1995	However, the slowing factors of the first hydrogen-bonded amide hydrogens are large, indicating the requirement for a reorganization of the calmodulin-peptide complex before the helix-coil transitions leading to exchange can occur.	Hydrogen	64-73	calmodulin 1	Homo sapiens	140-150
7663402-0	1995	1H and 13C NMR study of the molecular interaction mechanism between chloramphenicol and human serum albumin.	Hydrogen	0-2	albumin	Homo sapiens	94-107
7663402-1	1995	Molecular mechanism of the interaction between human serum albumin and cloramphenicol was studied by 1H and 13C NMR-spectroscopy.	Hydrogen	101-103	albumin	Homo sapiens	53-66
7827077-5	1995	The results show that the [BPh]dA6.dT17 base pair propeller twists and buckles slightly to permit the covalently attached benzo[c]phenanthrenyl ring to intercalate between the [BPh]dA6.dT17 and dC7.dG16 base pairs to the 3"-side of the [BPh]dA6 lesion site without disrupting the Watson-Crick hydrogen bond alignments in the modified duplex.	Hydrogen	293-301	a6	Drosophila melanogaster	31-34
7827077-5	1995	The results show that the [BPh]dA6.dT17 base pair propeller twists and buckles slightly to permit the covalently attached benzo[c]phenanthrenyl ring to intercalate between the [BPh]dA6.dT17 and dC7.dG16 base pairs to the 3"-side of the [BPh]dA6 lesion site without disrupting the Watson-Crick hydrogen bond alignments in the modified duplex.	Hydrogen	293-301	a6	Drosophila melanogaster	181-184
7827090-8	1995	In both the rhodopsin and bathorhodopsin models, we have included a structural water molecule hydrogen bonded with the Schiff base to account for the high C = N stretching vibrations previously observed.	Hydrogen	94-102	rhodopsin	Homo sapiens	12-21
7827077-5	1995	The results show that the [BPh]dA6.dT17 base pair propeller twists and buckles slightly to permit the covalently attached benzo[c]phenanthrenyl ring to intercalate between the [BPh]dA6.dT17 and dC7.dG16 base pairs to the 3"-side of the [BPh]dA6 lesion site without disrupting the Watson-Crick hydrogen bond alignments in the modified duplex.	Hydrogen	293-301	a6	Drosophila melanogaster	181-184
7711252-2	1995	Two spectral species were found in the chlorophyll T-S spectra of CP47, which may arise from a difference in ligation of the pigments or from an additional hydrogen bond, similar to what has been found for Chl molecules in a variety of solvents.	Hydrogen	156-164	beaded filament structural protein 2	Homo sapiens	66-70
7605135-1	1995	The molecular mechanisms of interaction were investigated in a model system of human serum albumin and chloramphenicol by a spectroscopic method of 1H and 13C NMR.	Hydrogen	148-150	albumin	Homo sapiens	85-98
7874691-3	1995	In HeLa cells farnesol caused translocation of PKC from membrane fraction to cytosol after 1h of incubation and also prevented PMA-stimulated induction of PKC translocation from cytosol to membranes.	Hydrogen	91-93	proline rich transmembrane protein 2	Homo sapiens	47-50
7527658-6	1994	In the presence of MBP, the hydrogen bond network is replaced by electrostatic interactions of the protein with the polar headgroups of the lipid.	Hydrogen	28-36	myelin basic protein	Bos taurus	19-22
7880965-6	1995	Taken together, the results reported herein provide insights into the role of hydrogen bonding and steric interactions for binding to renin.	Hydrogen	78-86	renin	Homo sapiens	134-139
7773176-10	1995	The interaction between colipase and the C-terminal domain of lipase is stabilized by eight hydrogen bonds and about 80 van der Waals contacts.	Hydrogen	92-100	colipase	Homo sapiens	24-32
7727060-10	1994	Further, the detailed interactions between UpA and RNase A are characterized in terms of hydrogen bonds and energetics.	Hydrogen	89-97	proline rich acidic protein 1	Homo sapiens	43-46
7957953-0	1994	A 1H NMR NOE study on Co(II) stellacyanin: some clues about the structure of the metal site.	Hydrogen	2-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
7899259-6	1994	The enhancement of the neuropeptide Y-induced pressor response by the H1 specific antagonist mepyramine was significantly more pronounced compared to the H2-selective agent.	Hydrogen	154-156	neuropeptide Y	Rattus norvegicus	23-37
7773779-4	1994	1H NMR analysis of the complex between the Ser-32-GRB2-N-SH3 domain and the proline-rich peptide VPPPVPPRRR, derived from h-Sos, shows that relative to the SH3 peptide complexes described for PI3K, Fyn and Abl, the proline-rich peptide in this complex binds in the opposite orientation.	Hydrogen	0-2	growth factor receptor bound protein 2	Homo sapiens	50-54
7773779-4	1994	1H NMR analysis of the complex between the Ser-32-GRB2-N-SH3 domain and the proline-rich peptide VPPPVPPRRR, derived from h-Sos, shows that relative to the SH3 peptide complexes described for PI3K, Fyn and Abl, the proline-rich peptide in this complex binds in the opposite orientation.	Hydrogen	0-2	xylosyltransferase 2	Homo sapiens	124-127
7695089-0	1994	Quantitation of dermatan sulfate active site for heparin cofactor II by 1H nuclear magnetic resonance spectroscopy.	Hydrogen	72-74	serpin family D member 1	Sus scrofa	49-68
7957953-1	1994	The 1H NMR spectrum of Co(II) stellacyanin is reported, in which four signals not previously observed have been detected.	Hydrogen	4-6	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-29
7812156-0	1994	Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques.	Hydrogen	9-11	downstream of receptor kinase	Drosophila melanogaster	74-77
7881903-7	1994	The binding site of the ligand peptide (VPP-PVPPRRR) derived from the Sos protein was mapped on the GRB2 C-SH3 domain indirectly using 1H and 15N chemical shift changes, and directly using several intermolecular nuclear Overhauser effects.	Hydrogen	135-137	growth factor receptor bound protein 2	Homo sapiens	100-104
7947711-4	1994	In this paper, one- and two-dimensional (COSY and NOESY) 1H NMR are used to characterize the ligand-induced T to R transitions of wild-type and EB13Q mutant human zinc-insulin hexamers and to make sequence-specific assignments of all resonances in the aromatic region of the R6 complex with resorcinol.	Hydrogen	57-59	insulin	Homo sapiens	168-175
7873639-1	1994	The freezing water solutions of serum albumin in presence of additives of several organic compounds have been studied by 1H NMR spectroscopy.	Hydrogen	121-123	albumin	Homo sapiens	38-45
7812156-1	1994	The backbone 1H and 15N resonances of the N-terminal SH3 domain of the Drosophila signaling adapter protein, drk, have been assigned.	Hydrogen	13-15	downstream of receptor kinase	Drosophila melanogaster	109-112
7929400-7	1994	The mechanism of action of 15-lipoxygenase acting as an LTA4 synthase is proposed to involve removing the pro-R hydrogen atom at carbon-10 of 5(S)-HPETE, which is antarafacial to the hydroperoxy group to yield LTA4.	Hydrogen	112-120	arachidonate 15-lipoxygenase	Homo sapiens	27-42
7804727-0	1994	Effect of hydrogen on the pathway and products of PCB dechlorination.	Hydrogen	10-18	pyruvate carboxylase	Homo sapiens	50-53
7966276-4	1994	It was found that the N terminus of alpha-helices is characterized by recurring sch:mch and sch:sch bonds with elements of the preceding coil segment, while at the C terminus a frequent intra-helix sch:mch hydrogen bond was frequently observed.	Hydrogen	206-214	pro-melanin concentrating hormone	Homo sapiens	202-205
7804727-2	1994	Under H2/CO2, 2,3,4-CBP was dechlorinated to 2,4-,2,3-, and then 2-CBP.	Hydrogen	6-8	CREB binding protein	Homo sapiens	20-23
7804727-2	1994	Under H2/CO2, 2,3,4-CBP was dechlorinated to 2,4-,2,3-, and then 2-CBP.	Hydrogen	6-8	CREB binding protein	Homo sapiens	67-70
7849249-8	1994	Together, these data support the view that HS is a highly specific ligand for NP receptors, capable of antagonizing the renal effects not only of exogenous ANP, but also those of BNP and URO.	Hydrogen	43-45	natriuretic peptide B	Rattus norvegicus	179-182
8049234-6	1994	The contributions of hydrogen bonding and hydrophobic interactions to the stability of interleukin-1 beta are analyzed and compared to those for other globular proteins.	Hydrogen	21-29	interleukin 1 beta	Homo sapiens	87-105
7727373-6	1994	When the reaction was conducted in the presence of CO, H2, or titanium(III), or in the absence of any electron donor, the rate of demethylation of syringic acid at pH 7.2 was approximately 15 nmol min-1 mg-1.	Hydrogen	55-57	CD59 molecule (CD59 blood group)	Homo sapiens	197-207
8086423-0	1994	Amide hydrogen exchange of the central B-chain helix within the T- and R-states of insulin hexamers.	Hydrogen	6-14	insulin	Homo sapiens	83-90
8086423-1	1994	Comparative analysis of the 1H-NMR spectra of human insulin shows that in the presence of the allosteric ligand, phenol, the tertiary structure of the protein is altered as evidenced by the decreased rate of amide hydrogen-deuterium exchange.	Hydrogen	28-30	insulin	Homo sapiens	52-59
8086423-1	1994	Comparative analysis of the 1H-NMR spectra of human insulin shows that in the presence of the allosteric ligand, phenol, the tertiary structure of the protein is altered as evidenced by the decreased rate of amide hydrogen-deuterium exchange.	Hydrogen	214-222	insulin	Homo sapiens	52-59
8060992-2	1994	At the N-terminus of helix 2 of human growth hormone there are two residues, Ser71 and Glu74, which form two reciprocal hydrogen bonds between the side chains and the backbone nitrogens of either residue (the N-capping box).	Hydrogen	120-128	growth hormone 1	Homo sapiens	38-52
8033884-0	1994	Probing hydrogen-bonding interactions of bovine heart galectin-1 and methyl beta-lactoside by use of engineered ligands.	Hydrogen	8-16	galectin 1	Bos taurus	54-64
7518522-1	1994	The conformations of two backbone-cyclized substance P analogs as derived from 1H NMR and molecular dynamics simulations carried out in DMSO and water are described.	Hydrogen	79-81	tachykinin precursor 1	Homo sapiens	43-54
8048549-0	1994	Hydrogen and potassium regulation of (pro)renin processing and secretion.	Hydrogen	0-8	renin	Homo sapiens	42-47
7835410-1	1994	Two-dimensional 1H NMR spectroscopic studies are presented on bovine gamma S- and gamma B-crystallin.	Hydrogen	16-18	crystallin gamma B	Bos taurus	82-100
8025104-1	1994	Site-directed mutagenesis is used in conjunction with 1H nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopy in order to find an insulin species amenable for structure determination in aqueous solution by NMR spectroscopy.	Hydrogen	54-56	insulin	Homo sapiens	151-158
8025104-2	1994	A successful candidate in this respect, i.e., B16 Tyr--&gt;His mutant insulin, is identified and selected for detailed characterization by two-dimensional 1H NMR.	Hydrogen	155-157	insulin	Homo sapiens	70-77
7578804-9	1994	Other linkers formed hydrogen bonds with the thrombin S" subsite residues Glu39, leu40, and Gln 151.	Hydrogen	21-29	coagulation factor II, thrombin	Homo sapiens	45-53
8033884-6	1994	Hydrogen-bonding interactions are almost exclusively restricted to the other side of the molecule: the C-4" and C-6" hydroxyl groups act as donors of the strongest hydrogen bonds to charged groups of the lectin, while the C-3 hydroxyl group participates in a strong hydrogen bond with a neutral group.	Hydrogen	0-8	complement C4	Bos taurus	103-106
8033884-6	1994	Hydrogen-bonding interactions are almost exclusively restricted to the other side of the molecule: the C-4" and C-6" hydroxyl groups act as donors of the strongest hydrogen bonds to charged groups of the lectin, while the C-3 hydroxyl group participates in a strong hydrogen bond with a neutral group.	Hydrogen	164-172	complement C4	Bos taurus	103-106
8033884-6	1994	Hydrogen-bonding interactions are almost exclusively restricted to the other side of the molecule: the C-4" and C-6" hydroxyl groups act as donors of the strongest hydrogen bonds to charged groups of the lectin, while the C-3 hydroxyl group participates in a strong hydrogen bond with a neutral group.	Hydrogen	266-274	complement C4	Bos taurus	103-106
8195191-2	1994	In this study, we have elucidated the structure of this novel adduct with the use of mass spectrometry, as well as 1H and 13C NMR as a substitution product of a -C(Cl) = CCl2 moiety for a beta-hydrogen atom on the prosthetic heme"s ring I vinyl group.	Hydrogen	115-117	amyloid beta precursor protein	Homo sapiens	186-192
7664062-3	1994	Our results, obtained by molecular-sieve chromatography and hydrogen-exchange measurements, show that apo-alpha-lactalbumin in this molten globule state is not bound to GroEL either in the absence or in the presence of KCl.	Hydrogen	60-68	lactalbumin alpha	Homo sapiens	106-123
8195191-2	1994	In this study, we have elucidated the structure of this novel adduct with the use of mass spectrometry, as well as 1H and 13C NMR as a substitution product of a -C(Cl) = CCl2 moiety for a beta-hydrogen atom on the prosthetic heme"s ring I vinyl group.	Hydrogen	193-201	amyloid beta precursor protein	Homo sapiens	186-192
8196060-3	1994	In these instances, however, the sp2 nitrogen atoms tend to form stacked interactions with the aromatic rings, these geometries outnumbering amino/aromatic hydrogen bonds by around 2.5:1.	Hydrogen	156-164	Sp2 transcription factor	Homo sapiens	33-36
8140420-2	1994	An IL-8 analog was chemically synthesized, with the amide nitrogen of leucine-25 methylated to selectivity block formation of hydrogen bonds between monomers and thereby prevent dimerization.	Hydrogen	126-134	C-X-C motif chemokine ligand 8	Homo sapiens	3-7
8024054-7	1994	The adrenal sensitivity to ACTH increased after H2 on day 2 and was similar after H2 on both days.	Hydrogen	48-50	proopiomelanocortin	Canis lupus familiaris	27-31
8204599-0	1994	1H NMR studies of interleukin 8 analogs: characterization of the domains essential for function.	Hydrogen	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
8204599-1	1994	1H NMR studies were carried out on interleukin 8 (IL-8) analogs in order to probe the structural features that are essential for receptor binding and function.	Hydrogen	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
8204599-1	1994	1H NMR studies were carried out on interleukin 8 (IL-8) analogs in order to probe the structural features that are essential for receptor binding and function.	Hydrogen	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
8204659-8	1994	The 1H NMR spectra showed Pb-induced changes in the same aliphatic and aromatic resonances of osteocalcin that are also affected by Ca(2+)-binding, supporting interaction of Pb2+ at the Ca2+ site.	Hydrogen	4-6	bone gamma-carboxyglutamate protein	Homo sapiens	94-105
8180184-10	1994	Interestingly, parallels exist between this residue and Asp83 in the visual receptor rhodopsin which has recently been found to exist in a protonated form and to undergo an almost identical change in hydrogen bonding during rhodopsin activation.	Hydrogen	200-208	rhodopsin	Homo sapiens	85-94
8180184-10	1994	Interestingly, parallels exist between this residue and Asp83 in the visual receptor rhodopsin which has recently been found to exist in a protonated form and to undergo an almost identical change in hydrogen bonding during rhodopsin activation.	Hydrogen	200-208	rhodopsin	Homo sapiens	224-233
8155707-1	1994	Solution conformation of CD4 fragment 81-92 TYICEVEDQKEE and two of its benzylated analogues was determined by two-dimensional 1H NMR spectroscopy, distance geometry and simulated annealing techniques.	Hydrogen	127-129	CD4 molecule	Homo sapiens	25-28
8011951-2	1994	This database is made of all the pairing schemes of the triplets ATT, GCC+, ATA and GCG where the third base forms two hydrogen bonds with the purine of the first two Watson-Crick strands.	Hydrogen	119-127	glucagon	Homo sapiens	84-87
8180215-1	1994	Pulsed hydrogen exchange labeling has been used in conjunction with circular dichroism in the near and far UV to study the refolding of human lysozyme from its guanidinium chloride denatured state.	Hydrogen	7-15	lysozyme	Homo sapiens	142-150
8181476-1	1994	The solution structure of the human plasminogen kringle 1 domain complexed to the antifibrinolytic drug 6-aminohexanoic acid (epsilon Ahx) was obtained on the basis of 1H-NMR spectroscopic data and dynamical simulated annealing calculations.	Hydrogen	168-170	nuclear receptor subfamily 0 group B member 1	Homo sapiens	134-137
8142350-1	1994	We have used 2D 1H NMR to determine the structure of glucagon-like peptide-1-(7-36) amide bound to a dodecylphosphocholine micelle.	Hydrogen	16-18	glucagon	Homo sapiens	53-76
8132568-8	1994	Based on the crystal structure, Arg133 hydrogen bonds to the P-7 backbone carbonyl of PKI(5-24).	Hydrogen	39-47	solute carrier family 10 member 7	Homo sapiens	61-64
8144889-7	1994	Collectively, these data were consistent with the peptide binding in a nonrepeating conformation with the vast majority of the free energy of binding arising from hydrogen bonds with the peptide backbone and a single, key hydrophobic side chain interacting in a conserved pocket in both DRB1*0101 and DRB1*0401.	Hydrogen	163-171	major histocompatibility complex, class II, DR beta 1	Homo sapiens	287-291
8136365-7	1994	The 1H-15N NOE data indicate that the scFv backbone has a well-defined structure of limited conformational flexibility.	Hydrogen	4-6	immunglobulin heavy chain variable region	Homo sapiens	38-42
8144889-7	1994	Collectively, these data were consistent with the peptide binding in a nonrepeating conformation with the vast majority of the free energy of binding arising from hydrogen bonds with the peptide backbone and a single, key hydrophobic side chain interacting in a conserved pocket in both DRB1*0101 and DRB1*0401.	Hydrogen	163-171	major histocompatibility complex, class II, DR beta 1	Homo sapiens	301-305
8126706-0	1994	The solution structure of a monocyclic analogue of endothelin [1,15 Aba]-ET-1, determined by 1H NMR spectroscopy.	Hydrogen	93-95	endothelin 1	Homo sapiens	73-77
8177196-8	1994	These results suggest that postoperative PMN signal transduction mechanisms, mediated by protein kinase C, may activate myeloperoxidase-H2-O2-halide system but suppress NADPH oxidase system dependently of the degree of surgical stress, revealing a differential effect of protein kinase C activation on PMN microbicidal activity.	Hydrogen	136-138	myeloperoxidase	Homo sapiens	120-135
11539492-4	1994	These values correspond to fractional abundances relative to molecular hydrogen of fNS approximately 8 x 10(-10) for TMC-1, and fNS approximately 6 x 10(-10) for L134N.	Hydrogen	71-79	transmembrane channel like 1	Homo sapiens	117-122
7805525-6	1994	Both systolic pressure (SBP) and DBP were negatively correlated to Na(+)-K(+)-pump (P &lt; 0.01, 0.001), while Na(+)-K(+)-pump was negatively fasting, 1/2h, 1h, 2h insulin levels and insulin AUC (P &lt; 0.05, 0.05, 0.01, 0.01, respectively).	Hydrogen	157-159	D-box binding PAR bZIP transcription factor	Homo sapiens	33-36
8110770-0	1994	The structure of human parathyroid hormone from a study of fragments in solution using 1H NMR spectroscopy and its biological implications.	Hydrogen	87-89	parathyroid hormone	Homo sapiens	23-42
8142585-0	1994	Conformational analysis of CCK-B agonists using 1H-NMR and restrained molecular dynamics: comparison of biologically active Boc-Trp-(N-Me) Nle-Asp-Phe-NH2 and inactive Boc-Trp-(N-Me)Phe-Asp-Phe-NH2.	Hydrogen	48-50	cholecystokinin B receptor	Homo sapiens	27-32
8107091-1	1994	The solution structure of the kringle domain from urokinase-type plasminogen activator (u-PA) has been determined using 1H nuclear magnetic resonance spectroscopy and dynamical simulated annealing calculations.	Hydrogen	120-122	plasminogen activator, urokinase	Homo sapiens	50-86
8107091-1	1994	The solution structure of the kringle domain from urokinase-type plasminogen activator (u-PA) has been determined using 1H nuclear magnetic resonance spectroscopy and dynamical simulated annealing calculations.	Hydrogen	120-122	plasminogen activator, urokinase	Homo sapiens	88-92
8305444-9	1994	The temperature dependence of 1H spin-lattice (T1) relaxation time measurements revealed that the motional activation energies increased from the choline headgroup to the end of the acyl chains of AC2 molecules in the AC2 lipid particles formed by sonication.	Hydrogen	30-32	adenylate cyclase 2	Homo sapiens	197-200
8305444-9	1994	The temperature dependence of 1H spin-lattice (T1) relaxation time measurements revealed that the motional activation energies increased from the choline headgroup to the end of the acyl chains of AC2 molecules in the AC2 lipid particles formed by sonication.	Hydrogen	30-32	adenylate cyclase 2	Homo sapiens	218-221
8305444-8	1994	1H NMR experiments using Mn2+ as a broadening reagent indicated that Mn2+ was accessible to all of the AC2 phospholipid headgroups in the AC2 lipid particles formed by sonication.	Hydrogen	0-2	adenylate cyclase 2	Homo sapiens	103-106
8305444-8	1994	1H NMR experiments using Mn2+ as a broadening reagent indicated that Mn2+ was accessible to all of the AC2 phospholipid headgroups in the AC2 lipid particles formed by sonication.	Hydrogen	0-2	adenylate cyclase 2	Homo sapiens	138-141
8114677-12	1994	In addition, arguments are presented that suggest that a hydrogen-bonding interaction occurs between the human 5-HT2A receptor at Ser242 and the N1-hydrogen of N1-unsubstituted ergolines and tryptamines and may serve as an important contact point in the receptor.	Hydrogen	57-65	5-hydroxytryptamine receptor 2A	Homo sapiens	111-126
8114677-12	1994	In addition, arguments are presented that suggest that a hydrogen-bonding interaction occurs between the human 5-HT2A receptor at Ser242 and the N1-hydrogen of N1-unsubstituted ergolines and tryptamines and may serve as an important contact point in the receptor.	Hydrogen	148-156	5-hydroxytryptamine receptor 2A	Homo sapiens	111-126
8136324-3	1993	Maps of the water distribution in the cubic insulin crystal show some well-ordered waters, which are bound to surrounding protein atoms by multiple hydrogen bonds, and an ill-defined solvent structure at a greater distance from the protein surface.	Hydrogen	148-156	insulin	Homo sapiens	44-51
8292035-0	1994	The interaction of calmodulin and polylysine as studied by 1H NMR spectroscopy and sedimentation equilibrium centrifugation.	Hydrogen	59-61	calmodulin 1	Homo sapiens	19-29
8292035-4	1994	1H NMR studies of the aromatic region of calmodulin identified chemical shifts of three peaks at a calmodulin:polylysine molar ratio of 1:1.	Hydrogen	0-2	calmodulin 1	Homo sapiens	41-51
8292035-4	1994	1H NMR studies of the aromatic region of calmodulin identified chemical shifts of three peaks at a calmodulin:polylysine molar ratio of 1:1.	Hydrogen	0-2	calmodulin 1	Homo sapiens	99-109
8142894-1	1994	We have utilized Raman difference spectroscopy to investigate hydrogen bonding interactions of the guanine moiety in guanine nucleotides with the binding site of two G proteins, EF-Tu (elongation factor Tu from Escherichia coli) and the c-Harvey ras protein, p21 (the gene product of the human c-H-ras proto-oncogene).	Hydrogen	62-70	Tu translation elongation factor, mitochondrial	Homo sapiens	178-183
8142894-8	1994	Despite the structural similarity of the binding sites of EF-Tu and p21, the strengths of the observed hydrogen bonds at the 6-keto and 2-amino positions vary substantially, by up to a factor of 2.	Hydrogen	103-111	Tu translation elongation factor, mitochondrial	Homo sapiens	58-63
8262263-2	1993	The structure of the carboxy-terminal domain of bovine calmodulin, TR2C, in the calcium-free form was investigated using two-dimensional 1H NMR.	Hydrogen	137-139	calmodulin	Bos taurus	55-65
8138192-10	1993	Hydrogen-peroxide-dependent mitochondrial lipid peroxidation varied with cytochrome c concentration, remaining close to controls when cytochrome c concentration decreased by 66%, even though there was no catalase present.	Hydrogen	0-8	catalase	Rattus norvegicus	204-212
8129872-7	1993	The conformation of the type III C-telopeptide is mostly extended except for a beta-turn ranging from Gly8 to Glu11, which is stabilized by a hydrogen-bond between NH of Glu11 and the carbonyl group of Gly8.	Hydrogen	142-150	amyloid beta precursor protein	Homo sapiens	77-83
8308892-1	1994	The tertiary structure of the fourth and fifth type 1 module pair from the N terminus of human fibronectin, has been determined by two-dimensional homonuclear 1H nuclear magnetic resonance (NMR) spectroscopy.	Hydrogen	159-161	fibronectin 1	Homo sapiens	95-106
7507172-0	1994	1H NMR analysis of the partly-folded non-native two-disulphide intermediates (30-51,5-14) and (30-51,5-38) in the folding pathway of bovine pancreatic trypsin inhibitor.	Hydrogen	0-2	trophoblast Kunitz domain protein 1	Bos taurus	151-168
8307026-0	1994	1H resonance assignments and secondary structure of the carbon monoxide complex of soybean leghemoglobin determined by homonuclear two-dimensional and three-dimensional NMR spectroscopy.	Hydrogen	0-2	leghemoglobin A	Glycine max	91-104
8307026-1	1994	Homonuclear two-dimensional and three-dimensional 1H-NMR spectroscopy has been utilized to study the 15.9-kDa protein soybean leghemoglobin.	Hydrogen	50-52	leghemoglobin A	Glycine max	126-139
8307026-4	1994	The secondary structure of leghemoglobin in solution has been determined on the basis of NOE connectivity patterns, hydrogen exchange and chemical-shift analyses.	Hydrogen	116-124	leghemoglobin A	Glycine max	27-40
8307026-7	1994	The hydrogen exchange behavior for the F helix and at the beginning of the A helix suggests different dynamic stability compared to other helical regions in leghemoglobin.	Hydrogen	4-12	leghemoglobin A	Glycine max	157-170
8307040-1	1994	Two synthetic peptides corresponding to the C-terminal 19 residues of human and murine interleukin-6, respectively, have been synthesized and their structures in solution investigated using high-resolution 1H-NMR spectroscopy.	Hydrogen	206-208	interleukin 6	Mus musculus	87-100
8241165-1	1993	We report the NMR assignments for the main-chain 13C, 15N, and 1H resonances (1HN, 1H alpha, 15N alpha, 13C alpha, 13CO) for the 19.5-kDa catalytic domain of human stromelysin-1, a zinc endoproteinase thought to be involved in pathologic tissue degradation.	Hydrogen	63-65	matrix metallopeptidase 3	Homo sapiens	164-177
8241165-1	1993	We report the NMR assignments for the main-chain 13C, 15N, and 1H resonances (1HN, 1H alpha, 15N alpha, 13C alpha, 13CO) for the 19.5-kDa catalytic domain of human stromelysin-1, a zinc endoproteinase thought to be involved in pathologic tissue degradation.	Hydrogen	78-80	matrix metallopeptidase 3	Homo sapiens	164-177
8130365-1	1993	1H nuclear magnetic resonance has been used to determine the effect of acute iv administration of the arginine vasopressin analog 1-(3-mercaptopropionic acid)-8-D-arginine vasopressin monoacetate (ddAVP; 2 micrograms) on renal medullary trimethylamine (TMA) levels in human volunteers.	Hydrogen	0-2	arginine vasopressin	Homo sapiens	111-122
8130365-1	1993	1H nuclear magnetic resonance has been used to determine the effect of acute iv administration of the arginine vasopressin analog 1-(3-mercaptopropionic acid)-8-D-arginine vasopressin monoacetate (ddAVP; 2 micrograms) on renal medullary trimethylamine (TMA) levels in human volunteers.	Hydrogen	0-2	arginine vasopressin	Homo sapiens	172-183
8136024-5	1993	We further conclude that hydrogen-bonding capacity or special side-chain packing characteristics are required at the B26 position for insulin to display high biological activity.	Hydrogen	25-33	insulin	Homo sapiens	134-141
8216311-0	1993	Use of thiocyanate ion as a mediator ligand in connecting acidic and alkaline forms of ferric myoglobin via paramagnetic 1H-NMR saturation transfer.	Hydrogen	121-123	myoglobin	Equus caballus	94-103
7507750-0	1993	Sequence-specific 1H-NMR assignments and folding topology of human CD59.	Hydrogen	18-20	CD59 molecule (CD59 blood group)	Homo sapiens	67-71
8218216-0	1993	Role of hydrogen bonding to bound dioxygen in soybean leghemoglobin.	Hydrogen	8-16	leghemoglobin A	Glycine max	54-67
8218216-7	1993	A discussion of the contribution of this hydrogen bond to the pH-dependent O2 affinity of leghemoglobin is presented.	Hydrogen	41-49	leghemoglobin A	Glycine max	90-103
8215451-3	1993	The compound was isolated from the products of the 5-lipoxygenase reaction and its structure elucidated by UV spectroscopy, LC-MS, two-dimensional [1H]NMR spectroscopy and chemical reduction to the corresponding alcohol.	Hydrogen	148-150	arachidonate 5-lipoxygenase	Homo sapiens	51-65
8298016-4	1993	This asymmetry is ascribed to the emergence of a predominant lipid population consisting of free sn1- and hydrogen-bonded (hydrated) sn2-ester carbonyl groups.	Hydrogen	106-114	solute carrier family 38 member 5	Homo sapiens	133-136
8216311-1	1993	Paramagnetic 1H-NMR saturation transfer experiments have been used successfully to connect acidic and alkaline forms of equine ferric myoglobin through met-thiocyanate form as a mediator.	Hydrogen	13-15	myoglobin	Equus caballus	134-143
8261908-5	1993	The heritabilities for milk urea were estimated in German Simmental cows as h2 = 0.06 +/- 0.04 and in German Brown cows as h2 = 0.25 +/- 0.11.	Hydrogen	76-78	Weaning weight-maternal milk	Bos taurus	23-27
7690588-0	1993	Protein internal flexibility and global stability: effect of urea on hydrogen exchange rates of bovine pancreatic trypsin inhibitor.	Hydrogen	69-77	trophoblast Kunitz domain protein 1	Bos taurus	114-131
8399169-0	1993	Fourier transform infrared difference spectroscopy of rhodopsin mutants: light activation of rhodopsin causes hydrogen-bonding change in residue aspartic acid-83 during meta II formation.	Hydrogen	110-118	rhodopsin	Homo sapiens	54-63
8399169-0	1993	Fourier transform infrared difference spectroscopy of rhodopsin mutants: light activation of rhodopsin causes hydrogen-bonding change in residue aspartic acid-83 during meta II formation.	Hydrogen	110-118	rhodopsin	Homo sapiens	93-102
8399164-4	1993	Complete 1H and 15N NMR resonance assignment of a 50-residue TFIIS peptide-Zn2+ complex is obtained.	Hydrogen	9-11	transcription elongation factor A2	Homo sapiens	61-66
7690588-1	1993	The hydrogen isotope exchange kinetics of buried NH protons in bovine pancreatic trypsin inhibitor (BPTI) was measured in 8 M urea at 30 degrees C and pH 3.5.	Hydrogen	4-12	trophoblast Kunitz domain protein 1	Bos taurus	81-98
8357794-1	1993	The complete 1H NMR assignments have been obtained for five mutant proteins of calbindin D9k and the three-dimensional solution structures determined for two of the mutants.	Hydrogen	13-15	S100 calcium binding protein G	Homo sapiens	79-92
19213150-0	1993	Calcium-hydrogen exchange by the plasma membrane Ca-ATPase of voltage-clamped snail neurons.	Hydrogen	8-16	snail family transcriptional repressor 1	Homo sapiens	78-83
8349322-9	1993	These findings therefore indicate that the arginine vasopressin-induced increase in intracellular sodium concentration is augmented in vascular smooth muscle cells of SHR mediated through the enhancement of the mobilization of cytosolic free calcium and the activity of sodium-hydrogen exchange, which depends on an increase in V1 receptor number.	Hydrogen	277-285	arginine vasopressin	Rattus norvegicus	52-63
8214072-4	1993	Measurement of the mucosal blood flow at the injected area with three different methods (laser-Doppler flowmetry, hydrogen gas clearance, and reflectance spectrophotometry) revealed that injected ET-1 produced an extremely long-lasting vasoconstriction.	Hydrogen	114-122	endothelin 1	Rattus norvegicus	196-200
7689976-2	1993	High-field proton (1H) nuclear magnetic resonance (NMR) spectroscopy has been employed to evaluate the formation of substance P carbamate in aqueous solution.	Hydrogen	19-21	tachykinin precursor 1	Homo sapiens	116-127
8356059-4	1993	In this report we have characterized (i) a pentapeptide, SLWDQ, found in both CD4 and HIV-1 gp120, which surprisingly had remained undetected in these two well-studied molecules until now, and (ii) an HLA sequence corresponding to the putative functional site of H2 I-A.	Hydrogen	263-265	CD4 molecule	Homo sapiens	78-81
8394123-4	1993	The acid stabilization of insulin"s conformation was attributed to the protonation of histidine at position 5 on the B-chain (HB5) as determined by 1H-NMR of the histidines, selective amino acid alteration, and enthalpies of ionization.	Hydrogen	148-150	insulin	Homo sapiens	26-33
8101078-4	1993	In this study, the H2-antagonists in clinical use were found to be potent inhibitors of MPO-catalysed reactions (IC50 &lt; 3 microM) under conditions resembling those in experiments with intact neutrophils.	Hydrogen	19-21	myeloperoxidase	Homo sapiens	88-91
8314753-3	1993	The 1H spectrum is analogous to that of the K2 domain of tissue-type plasminogen activator (tPA) and other homologous domains from the plasminogen (Pgn) heavy chain.	Hydrogen	4-6	plasminogen activator, tissue type	Homo sapiens	57-90
8314753-3	1993	The 1H spectrum is analogous to that of the K2 domain of tissue-type plasminogen activator (tPA) and other homologous domains from the plasminogen (Pgn) heavy chain.	Hydrogen	4-6	plasminogen activator, tissue type	Homo sapiens	92-95
8400617-1	1993	The secondary structure of a human growth hormone-releasing factor (hGRF) fragment (Leu27-hGRF(15-32)NH2) has been studied by 1H NMR at 500 MHz in aqueous solutions containing varying concentrations of d25-sodium dodecyl sulfate (SDS).	Hydrogen	126-128	growth hormone releasing hormone	Homo sapiens	35-66
8400617-1	1993	The secondary structure of a human growth hormone-releasing factor (hGRF) fragment (Leu27-hGRF(15-32)NH2) has been studied by 1H NMR at 500 MHz in aqueous solutions containing varying concentrations of d25-sodium dodecyl sulfate (SDS).	Hydrogen	126-128	growth hormone releasing hormone	Homo sapiens	68-72
8393341-1	1993	1H NMR chemical shift assignments for neuropeptide K (NPK) and neurokinin A (NKA) have been determined at 600 MHz in 28% trifluoroethanol/water solution.	Hydrogen	0-2	tachykinin precursor 1	Homo sapiens	38-52
8393341-1	1993	1H NMR chemical shift assignments for neuropeptide K (NPK) and neurokinin A (NKA) have been determined at 600 MHz in 28% trifluoroethanol/water solution.	Hydrogen	0-2	tachykinin precursor 1	Homo sapiens	54-57
8393341-1	1993	1H NMR chemical shift assignments for neuropeptide K (NPK) and neurokinin A (NKA) have been determined at 600 MHz in 28% trifluoroethanol/water solution.	Hydrogen	0-2	tachykinin precursor 1	Homo sapiens	63-75
8393341-1	1993	1H NMR chemical shift assignments for neuropeptide K (NPK) and neurokinin A (NKA) have been determined at 600 MHz in 28% trifluoroethanol/water solution.	Hydrogen	0-2	tachykinin precursor 1	Homo sapiens	77-80
8323944-6	1993	These data were complemented by 1H-NMR studies on the complex formed by calmodulin and a phospholamban peptide.	Hydrogen	32-34	calmodulin 1	Homo sapiens	72-82
8504087-0	1993	Structure and stability of the molten globule state of guinea-pig alpha-lactalbumin: a hydrogen exchange study.	Hydrogen	87-95	alpha-lactalbumin	Cavia porcellus	66-83
8504863-0	1993	1H and 15N assignments and secondary structure of the Src SH3 domain.	Hydrogen	0-2	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	54-57
8504863-1	1993	The 1H and 15N sequential assignments of the Src SH3 domain have been determined through a combination of 2D and 3D Nuclear Magnetic Resonance (NMR) methods.	Hydrogen	4-6	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	45-48
8504087-1	1993	A partially folded state of guinea pig alpha-lactalbumin (the A-state or molten globule state), formed by denaturation at low pH, has been studied using hydrogen exchange methods.	Hydrogen	153-161	alpha-lactalbumin	Cavia porcellus	39-56
8473304-0	1993	1H NMR-based determination of the three-dimensional structure of the human plasma fibronectin fragment containing inter-chain disulfide bonds.	Hydrogen	0-2	fibronectin 1	Homo sapiens	82-93
8389885-0	1993	Two-dimensional 1H nuclear magnetic resonance studies of the half-saturated (Ca2+)1 state of calbindin D9k.	Hydrogen	16-18	S100 calcium binding protein G	Homo sapiens	93-106
8391516-0	1993	Three-dimensional structure of human insulin-like growth factor-I (IGF-I) determined by 1H-NMR and distance geometry.	Hydrogen	88-90	insulin like growth factor 1	Homo sapiens	37-65
8391516-0	1993	Three-dimensional structure of human insulin-like growth factor-I (IGF-I) determined by 1H-NMR and distance geometry.	Hydrogen	88-90	insulin like growth factor 1	Homo sapiens	67-72
8387280-0	1993	Heteronuclear 113Cd-1H NMR study of metal coordination in the human retinoic acid receptor-beta DNA binding domain.	Hydrogen	20-22	retinoic acid receptor beta	Homo sapiens	68-95
8389149-0	1993	Different structure of the complexes of two cytochrome P-450 isozymes with acetanilide by 1H-NMR relaxation and spectrophotometry.	Hydrogen	90-92	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	44-60
8503960-0	1993	Three-dimensional structure of the complex between acyl-coenzyme A binding protein and palmitoyl-coenzyme A. Multidimensional 1H, 13C and 15N nuclear magnetic resonance spectroscopy has been used to study the complex between palmitoyl-coenzyme A and acyl-coenzyme A binding protein.	Hydrogen	126-128	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	51-82
8461302-2	1993	(1) The binding of the synergistic anion oxalate and Ga3+ to human serum transferrin (HTF, 80 kDa) and its recombinant N-lobe (HTF/2N, 40 kDa) has been studied by one- and two-dimensional 1H NMR spectroscopy, at 310 K, pH*7.25.	Hydrogen	188-190	transferrin	Homo sapiens	73-84
8475124-1	1993	We have used two-dimensional 1H NMR spectroscopy to study the conformation of the thrombin-binding aptamer d(GGTTGGTGTGGTTGG) in solution.	Hydrogen	29-31	coagulation factor II, thrombin	Homo sapiens	82-90
8461303-8	1993	Molecular dynamics simulation of the inhibitors with 13-atom linkers suggested that some linkers serve as a functional domain with the amide bond of the linker interacting with thrombin through hydrogen bonds.	Hydrogen	194-202	coagulation factor II, thrombin	Homo sapiens	177-185
8464050-1	1993	The backbone dynamics of the cytokine interleukin-8, a symmetric homodimer of overall molecular mass 16 kDa, has been investigated at pH 5.2 by means of 15N relaxation measurements using heteronuclear two-dimensional inverse detected 1H-15N spectroscopy.	Hydrogen	234-236	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
8485956-3	1993	insulin infusion (244 pmol kg-1h-1) for 180 min in 43 Type 1 diabetic patients and 22 nondiabetic subjects.	Hydrogen	30-32	insulin	Homo sapiens	0-7
8459402-7	1993	The electronic nature of the substituent had no significant effect on the efficacy of the compound, indicating that hydrogen bonding or polar interactions between the C-10 substituent of colchicinoids and an amino acid in the colchicine binding site on tubulin are not present in the colchicine-tubulin complex.	Hydrogen	116-124	homeobox C10	Homo sapiens	167-171
8462740-1	1993	An antiserum (anti-H2) directed at the second helix of the helix-loop-helix (HLH) protein MyoD1 reacts with a protein expressed during avian cardiac myocyte differentiation.	Hydrogen	19-21	myogenic differentiation 1	Homo sapiens	90-95
8462740-5	1993	Protein extracts from similarly staged hearts, when incubated with the muscle-specific enhancer sequence of muscle creatinine kinase (MCK), gave a stage-specific band shift in electromobility shift assays (EMSA), and these protein-DNA complexes were recognized and supershifted by anti-H2.	Hydrogen	286-288	creatine kinase, M-type	Homo sapiens	134-137
8450529-0	1993	Hydrogen-bonding contacts in the major groove are required for human immunodeficiency virus type-1 tat protein recognition of TAR RNA.	Hydrogen	0-8	RNA binding motif protein 8A	Homo sapiens	126-129
7680725-0	1993	Local structure due to an aromatic-amide interaction observed by 1H-nuclear magnetic resonance spectroscopy in peptides related to the N terminus of bovine pancreatic trypsin inhibitor.	Hydrogen	65-67	trophoblast Kunitz domain protein 1	Bos taurus	167-184
8444842-4	1993	In this report, a specific hexasaccharide having high affinity for recombinant human bFGF was isolated and its structure deduced by analysis of its reduced disaccharide products after treatment with nitrous acid at pH 1.5, and by 1H NMR spectroscopy.	Hydrogen	230-232	fibroblast growth factor 2	Homo sapiens	85-89
8450529-5	1993	Modifications to purines in the stem of TAR RNA that affect hydrogen-bonding ability in either the major or the minor groove of duplex RNA were also tested.	Hydrogen	60-68	RNA binding motif protein 8A	Homo sapiens	40-43
8450529-9	1993	We conclude that tat forms multiple specific hydrogen bonds to a series of dispersed sites displayed in the major groove of the TAR RNA molecule.	Hydrogen	45-53	RNA binding motif protein 8A	Homo sapiens	128-131
8436619-2	1993	Endothelin-1 (25 microliters of 10(-7)-10(-4) M) was applied to the adventitial surface of an exposed middle cerebral artery and striatal blood flow assessed by the hydrogen clearance technique.	Hydrogen	165-173	endothelin 1	Rattus norvegicus	0-12
8436742-5	1993	Basal and maximal myocardial blood flow in the angioplasty region and a normal region were determined in nine patients wtih positron emission tomography with H2(15)0 at 1 day (PET1), 7 days (PET2) and 3 months (PET3) after angioplasty.	Hydrogen	158-160	FEV transcription factor, ETS family member	Homo sapiens	176-180
8450416-4	1993	The hydrogen discharge is favored by the basic centers of the molecule in Co(II)/ammonia-buffered media.	Hydrogen	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-80
8477186-2	1993	A recently proposed 3D NMR experiment, CBCA(CO)NH, correlates C alpha and C beta resonances to the backbone amide 1H and 15N resonances of the next residue (Grzesiek, S. and Bax, A.	Hydrogen	114-116	BCL2 associated X, apoptosis regulator	Homo sapiens	174-177
8439536-1	1993	Two-dimensional 1H-NMR spectroscopy has been used to study the acid-denatured molten globule (A-state) of alpha-lactalbumin.	Hydrogen	16-18	lactalbumin alpha	Homo sapiens	106-123
8381363-0	1993	Identification of the adsorbing site of lysozyme onto the hydroxyapatite surface using hydrogen exchange and 1H NMR.	Hydrogen	87-95	lysozyme	Homo sapiens	40-48
8444150-4	1993	Analysis of the disaccharide products by 1H-NMR spectroscopy demonstrated that only beta-1-4 linkages were formed by the recombinant gal-T.	Hydrogen	41-43	galactose-1-phosphate uridylyltransferase	Homo sapiens	133-138
8433367-1	1993	The structure of a variant of human pancreatic secretory trypsin inhibitor (PSTI) has been determined by 1H nuclear magnetic resonance (n.m.r.)	Hydrogen	105-107	serine peptidase inhibitor Kazal type 1	Homo sapiens	36-74
8433367-1	1993	The structure of a variant of human pancreatic secretory trypsin inhibitor (PSTI) has been determined by 1H nuclear magnetic resonance (n.m.r.)	Hydrogen	105-107	serine peptidase inhibitor Kazal type 1	Homo sapiens	76-80
8381060-4	1993	We found that 1) HS dose-dependently reversed ANP- or BNP-induced decreases in RVR; 2) ANP or BNP at 100 nM caused an eightfold increase in cGMP production.	Hydrogen	17-19	natriuretic peptide B	Rattus norvegicus	54-57
8381060-4	1993	We found that 1) HS dose-dependently reversed ANP- or BNP-induced decreases in RVR; 2) ANP or BNP at 100 nM caused an eightfold increase in cGMP production.	Hydrogen	17-19	natriuretic peptide B	Rattus norvegicus	94-97
8381363-0	1993	Identification of the adsorbing site of lysozyme onto the hydroxyapatite surface using hydrogen exchange and 1H NMR.	Hydrogen	109-111	lysozyme	Homo sapiens	40-48
8381363-1	1993	The lysozyme-hydroxyapatite interaction was studied by measuring individual hydrogen-deuterium (H-D) exchange rates of amide protons.	Hydrogen	76-84	lysozyme	Homo sapiens	4-12
8422347-7	1993	1H, 13C, and 15N chemical shift data suggest that TAR residue A35 has an unusual local environment, consistent with extrusion of its base from the terminal loop.	Hydrogen	0-2	RNA binding motif protein 8A	Homo sapiens	50-53
8454567-5	1993	The upfield shift of 2-13C of MCAD relative to that of FMN in the aqueous medium and its downfield shift relative to that of tetraacetylriboflavin in an apolar medium imply that a weaker hydrogen bond exists between C(2) = O and apoMCAD or a water molecule than that of free FMN with a water molecule.	Hydrogen	187-195	acyl-CoA dehydrogenase medium chain	Homo sapiens	30-34
8422374-1	1993	The effect of 2,2,2-trifluoroethanol (TFE) on the solution conformation of hen egg white lysozyme has been investigated using circular dichroism (CD) and 1H nuclear magnetic resonance (NMR) spectroscopy.	Hydrogen	154-156	lysozyme	Homo sapiens	89-97
8484811-1	1993	1H-NMR spectra of the interleukin-2 synthetic fragment Ac-Leu66-Glu-Glu-Val-Leu-Asn-Leu72-OCH3 in the presence or absence of the monoclonal antibody were analysed.	Hydrogen	0-2	interleukin 2	Homo sapiens	22-35
7678096-9	1993	The 1H nuclear magnetic resonance spectra of human II Ang and Ang II were determined both separately and when combined in the same cuvette.	Hydrogen	4-6	angiotensinogen	Homo sapiens	62-68
1474585-12	1992	Herein, we describe hydrogen bonding in the various secondary structure elements and hydration of calmodulin.	Hydrogen	20-28	calmodulin	Bos taurus	98-108
8285076-4	1993	With reference to the general degradation rule of ethereal compound and the structure of the degradation products, we deduced that the ether linkage of I splits in acidic solutions by the catalysis of hydrogen ion, producing 3-quinuclidinol (DP1) and 1-phenyl-1-cyclopentyl glycol.	Hydrogen	201-209	transcription factor Dp-1	Homo sapiens	242-245
1335516-13	1992	showed that polypeptide amide 1H-2H exchange was greater in the native forms of alpha 1-AT, alpha 1-ACT and C1-INH than in their cleaved forms, whereas for ovalbumin it was unchanged.	Hydrogen	30-32	serpin family A member 1	Homo sapiens	80-90
8445154-6	1993	Infusion of the PRL at 100 micrograms/rat/day in pulses of 1h duration was ineffective at frequencies of either 4 or 8/day, whereas pulses of 2h duration were effective at both of these frequencies.	Hydrogen	59-61	prolactin	Rattus norvegicus	16-19
1483454-0	1992	1H-NMR assignments and local environments of aromatic residues in bovine, human and guinea pig variants of alpha-lactalbumin.	Hydrogen	0-2	alpha-lactalbumin	Cavia porcellus	107-124
1463719-10	1992	An extensive comparison with refined crystal structures of RNase-A reveals that the core of the molecule which is held together with extensive hydrogen bonds is in identical pattern in all cases.	Hydrogen	143-151	ribonuclease pancreatic	Bos taurus	59-66
1445905-3	1992	The interactions of D-Phe1"-Pro2"-beta-homoArg3" with the active site of thrombin were essentially identical to those of related structures of PPACK- (D-Phe-Pro-Arg chloromethyl ketone) and hirulog 1-thrombin, with the guanidinium function of the arginyl P1 residue forming a hydrogen-bonding ion pair with Asp189 of the S1 site.	Hydrogen	276-284	coagulation factor II, thrombin	Homo sapiens	73-81
1483454-1	1992	1H-NMR assignments have been defined for the aromatic-ring protons of the bovine, guinea pig and human variants of alpha-lactalbumin.	Hydrogen	0-2	lactalbumin alpha	Homo sapiens	115-132
1287652-4	1992	Even for serine and threonine side chains only two minimum energy sites are found in general of which one is in an expected position within hydrogen bonding of the hydroxyl hydrogen atom (unless this is blocked from interaction with solvent molecules by, for example, Oi-4 or Oi-3.	Hydrogen	140-148	collagen type I alpha 2 chain	Homo sapiens	268-272
1287652-4	1992	Even for serine and threonine side chains only two minimum energy sites are found in general of which one is in an expected position within hydrogen bonding of the hydroxyl hydrogen atom (unless this is blocked from interaction with solvent molecules by, for example, Oi-4 or Oi-3.	Hydrogen	173-181	collagen type I alpha 2 chain	Homo sapiens	268-272
1304890-0	1992	Crystal structure of the Y52F/Y73F double mutant of phospholipase A2: increased hydrophobic interactions of the phenyl groups compensate for the disrupted hydrogen bonds of the tyrosines.	Hydrogen	155-163	phospholipase A2 group IB	Homo sapiens	52-68
1359966-6	1992	The binding of Co(II) at pH 7.2 was also found to affect its 1H-NMR spectrum and this effect was reversed by lowering the pH to 6.1.	Hydrogen	61-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
1433291-2	1992	The solution structure of the B9(Asp) mutant of human insulin has been determined by two-dimensional 1H nuclear magnetic resonance spectroscopy.	Hydrogen	101-103	insulin	Homo sapiens	54-61
1337000-1	1992	1H alpha, 13C alpha, and 15N alpha secondary shifts, defined as the difference between the observed value and the random coil value, have been calculated for interleukin-1 receptor antagonist protein and interleukin-1 beta.	Hydrogen	0-2	interleukin 1 beta	Homo sapiens	204-222
1448813-5	1992	1H nuclear magnetic resonance (NMR) spectra show for the 17 beta-methyl epimer a chemical shift for the C-18 protons (singlet) of about 0.175 ppm (in deuterochloroform) to a lower field.	Hydrogen	0-2	Bardet-Biedl syndrome 9	Homo sapiens	104-108
1390775-1	1992	The fibronectin C-terminal interchain disulfide-linked heptapeptide dimer (Val-Asn-Cys-Pro-Ile-Glu-Cys)2 has been investigated via 1H NMR spectroscopy in both water and dimethyl sulfoxide (DMSO) solutions.	Hydrogen	131-133	fibronectin 1	Homo sapiens	4-15
1327776-7	1992	The purified hydrogenase showed a specific activity of 62 kU/mg of protein in the H2-uptake assay, and the H2-uptake activity was higher than H2-evolution activity.	Hydrogen	82-84	DVU2400	Desulfovibrio vulgaris str. Hildenborough	13-24
1456441-0	1992	N-glycosylation site mapping of human serotransferrin by serial lectin affinity chromatography, fast atom bombardment-mass spectrometry, and 1H nuclear magnetic resonance spectroscopy.	Hydrogen	141-143	transferrin	Homo sapiens	38-53
1329082-1	1992	Tyr-67 of mitochondrial cytochrome c is thought to be involved in important hydrogen bonding interactions in the hydrophobic heme pocket of the protein (Takano, T., Dickerson, R. E. (1981) J. Mol.	Hydrogen	76-84	cytochrome c, somatic	Homo sapiens	24-36
1322837-3	1992	Comparisons of hydrogen-deuterium solvent exchange rates for the NH protons of RNase A and RNase B were made using two-dimensional 1H correlation spectroscopy.	Hydrogen	15-23	ribonuclease pancreatic	Bos taurus	79-86
1390632-1	1992	To determine what drives the closure of the active-site loop in the reaction catalyzed by triosephosphate isomerase, several residues involved in hydrogen bonding between the loop and the bulk of the protein have been altered.	Hydrogen	146-154	triosephosphate isomerase 1	Homo sapiens	90-115
1390633-0	1992	Segmental motion in catalysis: investigation of a hydrogen bond critical for loop closure in the reaction of triosephosphate isomerase.	Hydrogen	50-58	triosephosphate isomerase 1	Homo sapiens	109-134
1390633-1	1992	A residue essential for proper closure of the active-site loop in the reaction catalyzed by triosephosphate isomerase is tyrosine-208, the hydroxyl group of which forms a hydrogen bond with the amide nitrogen of alanine-176, a component of the loop.	Hydrogen	171-179	triosephosphate isomerase 1	Homo sapiens	92-117
1422154-1	1992	The solution conformation of human big endothelin-1, a 38-residue peptide which serves as the putative precursor to the potent vasoconstrictor endothelin-1 has been examined by 1H NMR.	Hydrogen	177-179	endothelin 1	Homo sapiens	39-51
1333262-5	1992	Preliminary 1H studies of the RIF-1 tumor indicate that: (i) there are no significant changes in metabolite levels relative to tumor water during 4 days of untreated tumor growth; (ii) tumor response to chemotherapy with 5-fluorouracil results in a decrease in intensity of all metabolite 1H resonances relative to tumor water, with total choline decreasing the most and lactate the least; and (iii) acute tumor blood flow reduction induced by administration of hydralazine results in doubling of the lactate intensity relative to water.	Hydrogen	12-14	replication timing regulatory factor 1	Mus musculus	30-35
1525157-0	1992	1H, 13C, and 15N NMR backbone assignments and secondary structure of human interferon-gamma.	Hydrogen	0-2	interferon gamma	Homo sapiens	75-91
1525157-1	1992	1H, 13C, and 15N NMR assignments of the protein backbone of human interferon-gamma, a homodimer of 31.4 kDa, have been made using the recently introduced three-dimensional (3D) triple-resonance NMR techniques.	Hydrogen	0-2	interferon gamma	Homo sapiens	66-82
1322837-3	1992	Comparisons of hydrogen-deuterium solvent exchange rates for the NH protons of RNase A and RNase B were made using two-dimensional 1H correlation spectroscopy.	Hydrogen	131-133	ribonuclease pancreatic	Bos taurus	79-86
1629626-5	1992	Four amino acid replacements, resulting in a net positive change in non-hydrogen atoms in the S1" subsite of MC-CPA, were associated with less alteration in substrate specificity, relative to bovine CPA, than might be expected from studies using rat CPA1 and CPA2.	Hydrogen	72-80	carboxypeptidase A3	Homo sapiens	109-115
1637822-1	1992	Primary hydrogen isotope effects and steady-state kinetics have been used to study the mechanism of glyceraldehyde-3-phosphate (GAP) dehydrogenase at pH 8.6.	Hydrogen	8-16	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	100-146
1629626-5	1992	Four amino acid replacements, resulting in a net positive change in non-hydrogen atoms in the S1" subsite of MC-CPA, were associated with less alteration in substrate specificity, relative to bovine CPA, than might be expected from studies using rat CPA1 and CPA2.	Hydrogen	72-80	carboxypeptidase A1	Homo sapiens	112-115
1567880-0	1992	1H, 15N, 13C, and 13CO assignments of human interleukin-4 using three-dimensional double- and triple-resonance heteronuclear magnetic resonance spectroscopy.	Hydrogen	0-2	interleukin 4	Homo sapiens	44-57
1353610-4	1992	The new crystal structures of human SOD show that amino-acid site chains that are implicated in electrostatic guidance (Glu 132, Glu 133 and Lys 136) form a hydrogen-bonding network.	Hydrogen	157-165	superoxide dismutase 1	Homo sapiens	36-39
1524698-3	1992	The main mechanism of most drug interactions involving cimetidine appears to be inhibition of the hepatic microsomal enzyme cytochrome P450, an effect which may be related to the different structures of H2-antagonists.	Hydrogen	203-205	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	124-139
1588554-6	1992	SAR data suggested that the 1,3-dioxabutyl group (methoxymethyl ether) interacted by hydrogen bonding to groups in the S4 domain of renin.	Hydrogen	85-93	renin	Homo sapiens	132-137
1321662-1	1992	An 80 amino acid polypeptide corresponding to the DNA-binding domain (DBD) of the human retinoic acid receptor beta (hRAR-beta) has been studied by 1H homonuclear and 15N-1H heteronuclear two- and three-dimensional (2D and 3D) NMR spectroscopy.	Hydrogen	148-150	retinoic acid receptor beta	Homo sapiens	88-115
1608447-3	1992	Although the pattern of main-chain hydrogen bonding in other aspartic proteinase inhibitor complexes is conserved in renins, differences in the positions of secondary structure elements (particularly helices) also lead to improved specificity in renins for angiotensinogen substrates.	Hydrogen	35-43	angiotensinogen	Homo sapiens	257-272
1577733-0	1992	Studies of the association and conformational properties of metal-free insulin in alkaline sodium chloride solutions by one- and two-dimensional 1H NMR.	Hydrogen	145-147	insulin	Homo sapiens	71-78
1577733-1	1992	One- and two-dimensional 1H NMR spectroscopy have been employed to probe the association and subsequent conformational changes of metal-free insulin in sodium chloride solution at pH 9 and 9.4.	Hydrogen	25-27	insulin	Homo sapiens	141-148
1567880-1	1992	The assignment of the 1H, 15N, 13CO, and 13C resonances of recombinant human interleukin-4 (IL-4), a protein of 133 residues and molecular mass of 15.4 kDa, is presented based on a series of 11 three-dimensional (3D) double- and triple-resonance heteronuclear NMR experiments.	Hydrogen	22-24	interleukin 4	Homo sapiens	77-90
1567880-1	1992	The assignment of the 1H, 15N, 13CO, and 13C resonances of recombinant human interleukin-4 (IL-4), a protein of 133 residues and molecular mass of 15.4 kDa, is presented based on a series of 11 three-dimensional (3D) double- and triple-resonance heteronuclear NMR experiments.	Hydrogen	22-24	interleukin 4	Homo sapiens	92-96
1312711-6	1992	Compared with other proteins studied by pulse labeling, including cytochrome c, ribonuclease, and barnase, the initial formation of hydrogen-bonded structure in ubiquitin occurs at a more rapid rate and slow-folding species are less prominent.	Hydrogen	132-140	cytochrome c, somatic	Homo sapiens	66-78
1560535-2	1992	We investigated the hypothesis that the essential uridine residue at position 23 in the bulge of TAR RNA is involved in intramolecular hydrogen bonding to stabilize an unique RNA structure required for recognition by Tat.	Hydrogen	135-143	RNA binding motif protein 8A	Homo sapiens	97-100
1325687-8	1992	If glutamate 387 of rat brain sodium channel II is the ion-pairing site for the guanidinium group, then the carbonyl oxygen of asparagine 388 is the hydrogen acceptor for the C-9 and C-10 -OHs.	Hydrogen	149-157	complement C9	Rattus norvegicus	175-178
1313424-2	1992	The structural domains of salivary statherin that are partly responsible for the protection and recalcification of tooth enamel were examined with respect to charge, sequence, hydrophobicity, hydrogen bonding potential, and conformation.	Hydrogen	192-200	statherin	Homo sapiens	35-44
1313424-10	1992	The C-terminal SC15 and SC25 fragments elicit a much higher affinity for HAP surface than that of the middle sequence (SM15), indicating that hydrogen bonding potential of the C-terminal sequence also contributes to the interaction of statherin with HAP.	Hydrogen	142-150	statherin	Homo sapiens	235-244
1499021-3	1992	Deprotonated O-3 is an acceptor of three hydrogen bonds, but does not interact with Li+.	Hydrogen	41-49	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	13-16
1364175-0	1992	[H2 antagonists as inhibitors of cytochrome P-450 in rat liver: in vitro and in vivo effects].	Hydrogen	1-3	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	33-49
1319992-0	1992	1H-NMR assignment and secondary structure of human insulin-like growth factor-I (IGF-I) in solution.	Hydrogen	0-2	insulin like growth factor 1	Homo sapiens	51-79
1319992-0	1992	1H-NMR assignment and secondary structure of human insulin-like growth factor-I (IGF-I) in solution.	Hydrogen	0-2	insulin like growth factor 1	Homo sapiens	81-86
1319992-1	1992	Human insulin-like growth factor-I (IGF-I) was studied by two-dimensional 1H-NMR spectroscopy.	Hydrogen	74-76	insulin like growth factor 1	Homo sapiens	6-34
1319992-1	1992	Human insulin-like growth factor-I (IGF-I) was studied by two-dimensional 1H-NMR spectroscopy.	Hydrogen	74-76	insulin like growth factor 1	Homo sapiens	36-41
1554355-4	1992	Although the two enzymes reduced various xenobiotic carbonyl compounds and the 3-oxo group of C19- and C21-steroids, and were A-specific in the hydrogen transfer from NADPH, only the pI 5.4 enzyme showed reductase activity towards 7 alpha-hydroxy-5 beta-cholestan-3-one and dehydrolithocholic acid.	Hydrogen	144-152	TBL1X/Y related 1	Homo sapiens	103-106
1617146-7	1992	The structures observed during molecular dynamics support the conclusion of the previous paper that hydrogen bonding will play the dominant role in antibody-insulin recognition.	Hydrogen	100-108	insulin	Homo sapiens	157-164
1542027-7	1992	Small values of a transcellular pH gradient can have large effects on enhancing transcellular calcium flow, provided the hydrogen ion concentration affects the binding of calcium to calbindin or the rate of diffusion of the calcium/calbindin complex.	Hydrogen	121-129	calbindin 1	Rattus norvegicus	182-191
1542027-7	1992	Small values of a transcellular pH gradient can have large effects on enhancing transcellular calcium flow, provided the hydrogen ion concentration affects the binding of calcium to calbindin or the rate of diffusion of the calcium/calbindin complex.	Hydrogen	121-129	calbindin 1	Rattus norvegicus	232-241
1372979-9	1992	The predictions from this method are compared to known hydrogen positions for bovine pancreatic trypsin inhibitor, insulin, RNase-A, and trypsin for which the neutron diffraction structures have been determined.	Hydrogen	55-63	ribonuclease pancreatic	Bos taurus	124-131
1531616-10	1992	The pathways for DNA damage involving C4" and C5" hydrogen atom abstraction thus share many common features, several of which are consistent with a mechanism for the production of NCS-mediated bistranded lesions at AGT.ACT that involves a tetraoxide bridge joining the lesions on opposite strands of DNA.	Hydrogen	50-58	angiotensinogen	Homo sapiens	215-218
1736987-1	1992	The conformational features of endothelin-1 (ET-1) in mixed water/ethylene glycol media have been studied by two-dimensional 1H NMR experiments throughout the pH range 3.2-7.2.	Hydrogen	125-127	endothelin 1	Homo sapiens	31-43
1550991-10	1992	A role for the vacuolar alpha-mannosidase in generating at least some heterogeneity in vivo was inferred from the 1H NMR spectrum of the AMS1 Man11GlcNAc pool, which showed more structural isomerism than seen in the spectrum of a comparable ams1 Man11GlcNAc preparation.	Hydrogen	114-116	alpha-mannosidase	Saccharomyces cerevisiae S288C	137-141
1370625-4	1992	Sufficient purified LAR-D1 and LAR-D1D2 PTPases were available to demonstrate enzymatic exchange of 18O from 18O4 inorganic phosphate into H2(16)O at rates of approximately 1 x 10(-2) s-1.	Hydrogen	139-141	protein tyrosine phosphatase receptor type F	Homo sapiens	20-23
1370625-4	1992	Sufficient purified LAR-D1 and LAR-D1D2 PTPases were available to demonstrate enzymatic exchange of 18O from 18O4 inorganic phosphate into H2(16)O at rates of approximately 1 x 10(-2) s-1.	Hydrogen	139-141	protein tyrosine phosphatase receptor type F	Homo sapiens	31-34
1311202-0	1992	1H NMR assignment and secondary structure of the cell adhesion type III module of fibronectin.	Hydrogen	0-2	fibronectin 1	Homo sapiens	82-93
1550991-10	1992	A role for the vacuolar alpha-mannosidase in generating at least some heterogeneity in vivo was inferred from the 1H NMR spectrum of the AMS1 Man11GlcNAc pool, which showed more structural isomerism than seen in the spectrum of a comparable ams1 Man11GlcNAc preparation.	Hydrogen	114-116	alpha-mannosidase	Saccharomyces cerevisiae S288C	24-41
1537398-1	1992	1H nuclear magnetic resonance longitudinal relaxation time (T1) measurements were used to study the interaction of 1,3,6-H-benzo(a)pyrene (1,3,6-H-BaP) with microsomal cytochrome P-450 from livers of phenobarbital- and beta-naphthoflavone-treated rats.	Hydrogen	0-2	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	168-184
1731872-0	1992	1H and 15N NMR characterization of free and bound states of an amphiphilic peptide interacting with calmodulin.	Hydrogen	0-2	calmodulin 1	Homo sapiens	100-110
1377513-8	1992	Based on this model, it is suggested that hydrogen bonding may be key in the interaction between the human insulin A chain loop antigenic epitope and 125.	Hydrogen	42-50	insulin	Homo sapiens	107-114
1744095-5	1991	Hydrogen bonding occurs between Arg151 and the ring oxygen and 4-hydroxyl of the sugar ligand, two backbone carbonyls, and a side chain in ABP, and similar interactions in the lac repressor would be anticipated.	Hydrogen	0-8	sex hormone binding globulin	Homo sapiens	139-142
15092026-1	1992	Hydrogen ions in precipitation vary primarily with (SO4 + NO3) concentration.	Hydrogen	0-8	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
1501538-2	1992	One or two hours following exposure to CCl4, a localized edematous region was detected in the liver by 1H MRI.	Hydrogen	103-105	C-C motif chemokine ligand 4	Rattus norvegicus	39-43
1501538-5	1992	Pretreatment with alpha-phenyl-tert-butyl nitrone (PBN), a free radical spin trap, 30 min prior to CCl4 exposure, was found to reduce the CCl4-induced edematous response in the liver observed in either 1H or 23Na-NMR images.	Hydrogen	202-204	C-C motif chemokine ligand 4	Rattus norvegicus	138-142
1501538-7	1992	In addition, with the use of a 31P/1H double frequency tuned bird-cage imaging/spectroscopy coil, localized 31P spectra (ISIS) were obtained from the regions of CCl4-induced "tissue damage" observed in the 1H-MRI images.	Hydrogen	35-37	C-C motif chemokine ligand 4	Rattus norvegicus	161-165
1501538-7	1992	In addition, with the use of a 31P/1H double frequency tuned bird-cage imaging/spectroscopy coil, localized 31P spectra (ISIS) were obtained from the regions of CCl4-induced "tissue damage" observed in the 1H-MRI images.	Hydrogen	206-208	C-C motif chemokine ligand 4	Rattus norvegicus	161-165
1764074-5	1991	We here report the assignment of the structural reporter groups of each of them, and general rules applicable for the 1H-NMR spectrum analysis of linear manno-oligosaccharide of general structure: Man(beta 1-2) [Man(beta 1-2)]nMan	Hydrogen	118-120	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	201-209
1764074-5	1991	We here report the assignment of the structural reporter groups of each of them, and general rules applicable for the 1H-NMR spectrum analysis of linear manno-oligosaccharide of general structure: Man(beta 1-2) [Man(beta 1-2)]nMan	Hydrogen	118-120	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	216-224
1764475-1	1991	Two peroxidase isoenzymes from Cucumber seedlings, one acidic (pI = 4) and one basic (pI = 9), were characterized by 1H-NMR spectroscopy.	Hydrogen	117-119	peroxidase 2-like	Cucumis sativus	4-14
1761045-1	1991	A two-dimensional 1H-NMR study of des-(B26-B30)-insulin in combination with distance geometry and restrained molecular dynamics.	Hydrogen	18-20	insulin	Homo sapiens	48-55
1761045-2	1991	The solution conformation of des-(B26-B30)-insulin (DPI) has been investigated by 1H-NMR spectroscopy.	Hydrogen	82-84	insulin	Homo sapiens	43-50
1337977-5	1992	Moreover, the total amount of lipoxins synthesized by AM from AP was 2 fold higher than that synthesized by AM from HS, thus showing an enhanced cell activation via the 5-lipoxygenase (5-LO) pathway.	Hydrogen	116-118	arachidonate 5-lipoxygenase	Homo sapiens	169-183
1284147-2	1992	Several mechanisms have been proposed to explain hyperinsulinemia, insulin resistance and its relationship to hypertension; reduced sodium excretion, activation of the sympathetic nervous system, increased activity of the sodium/hydrogen pump, and stimulation of cellular growth.	Hydrogen	229-237	insulin	Homo sapiens	54-61
1824254-6	1991	The direct interaction of the IFN with GM-CFC was confirmed by showing its ability to rapidly activate the sodium/hydrogen antiport in GM-CFC, as do the mitogens GM-CSF, M-CSF, and IL-3.	Hydrogen	114-122	interferon alpha 1	Homo sapiens	30-33
1794972-0	1991	1H and 15N NMR study of human lysozyme.	Hydrogen	0-2	lysozyme	Homo sapiens	30-38
1794972-1	1991	The 15N signal assignment of human lysozyme was carried out by using 1H-1H and 1H-15N two dimensional experiments.	Hydrogen	69-71	lysozyme	Homo sapiens	35-43
1794972-1	1991	The 15N signal assignment of human lysozyme was carried out by using 1H-1H and 1H-15N two dimensional experiments.	Hydrogen	72-74	lysozyme	Homo sapiens	35-43
1794972-1	1991	The 15N signal assignment of human lysozyme was carried out by using 1H-1H and 1H-15N two dimensional experiments.	Hydrogen	72-74	lysozyme	Homo sapiens	35-43
1794991-0	1991	1H-NMR study on the structure of lysozyme from guinea hen egg white.	Hydrogen	0-2	lysozyme	Homo sapiens	33-41
1824254-7	1991	However, the effect of IFN-gamma on intracellular pH and DNA synthesis was transient and pretreatment with IFN markedly inhibited the ability of GM-CSF, M-CSF, and IL-3 to activate the sodium/hydrogen antiport.	Hydrogen	192-200	interferon gamma	Homo sapiens	23-32
1824254-7	1991	However, the effect of IFN-gamma on intracellular pH and DNA synthesis was transient and pretreatment with IFN markedly inhibited the ability of GM-CSF, M-CSF, and IL-3 to activate the sodium/hydrogen antiport.	Hydrogen	192-200	interferon alpha 1	Homo sapiens	23-26
1915851-6	1991	However, the 15N chemical shift of [5-15N]folate in the binary DHFR/folate complex is 7.28 ppm upfield from that of the ternary complex, suggesting the possible loss of a hydrogen bonding to N5 of folate in the ternary complex.	Hydrogen	171-179	dihydrofolate reductase	Escherichia coli	63-67
1932015-5	1991	The data show that the guanine amino group of the nucleotide interacts differently with both EF-Tu and p21 than it does with water, showing a change in hydrogen-bonding properties upon binding.	Hydrogen	152-160	Tu translation elongation factor, mitochondrial	Homo sapiens	93-98
1783604-0	1991	Mastoparan binding induces Ca(2+)-transfer between two globular domains of calmodulin: a 1H NMR study.	Hydrogen	89-91	calmodulin 1	Homo sapiens	75-85
1783604-1	1991	The interaction between calmodulin and mastoparan at various concentrations of calcium ions was studied by 1H NMR.	Hydrogen	107-109	calmodulin 1	Homo sapiens	24-34
1942057-4	1991	The hirugen-thrombin complex is the first thrombin structure determined to have an unobstructed active site; this site is practically identical in positioning of catalytic residues and in its hydrogen bonding pattern with that of other serine proteinases.	Hydrogen	192-200	coagulation factor II, thrombin	Homo sapiens	12-20
1942057-4	1991	The hirugen-thrombin complex is the first thrombin structure determined to have an unobstructed active site; this site is practically identical in positioning of catalytic residues and in its hydrogen bonding pattern with that of other serine proteinases.	Hydrogen	192-200	coagulation factor II, thrombin	Homo sapiens	42-50
1918053-0	1991	1H NMR and CD secondary structure analysis of cell adhesion promoting peptide F-9 from laminin.	Hydrogen	0-2	coagulation factor IX	Homo sapiens	78-81
1918053-1	1991	A heparin binding, cell adhesion promoting domain, termed peptide F-9, from the B1 chain of human laminin, residues 641 to 660, i.e. RYVVLPRPVCFEKGMNYTVR, has been investigated by 1H NMR (500 MHz) spectroscopy and CD spectropolarimetry.	Hydrogen	180-182	coagulation factor IX	Homo sapiens	66-69
1895380-11	1991	We hypothesize that the invariant U is involved in hydrogen bond interactions with either another part of TAR or the TAR-binding domain in Tat.	Hydrogen	51-59	RNA binding motif protein 8A	Homo sapiens	106-109
1895380-11	1991	We hypothesize that the invariant U is involved in hydrogen bond interactions with either another part of TAR or the TAR-binding domain in Tat.	Hydrogen	51-59	RNA binding motif protein 8A	Homo sapiens	117-120
1798698-0	1991	The solution structure and conformational dynamics of tumor necrosis factor-alpha and a (Cys69----Asp; Cys101----Arg) analog as examined by IR spectroscopy and hydrogen exchange.	Hydrogen	160-168	tumor necrosis factor	Homo sapiens	54-81
1920434-4	1991	The alpha-amino group of Ile1" of hirudin makes a hydrogen bond with OG of Ser195 of thrombin, the side-chains of Ile1" and Tyr3" occupy the apolar site, Thr2" is at the entrance to, but does not enter, the S1 specificity site and Ile1" to Tyr3" form a parallel beta-strand with Ser214 to Gly219.	Hydrogen	50-58	coagulation factor II, thrombin	Homo sapiens	85-93
1654278-1	1991	The interaction of Zn2+ with angiotensin I, a decapeptide containing two histidyl residues, has been studied by 1H-NMR spectroscopy in both water and dimethylsulfoxide.	Hydrogen	112-114	angiotensinogen	Homo sapiens	29-42
1911782-0	1991	Hydrogen exchange in thermally denatured ribonuclease A.	Hydrogen	0-8	ribonuclease pancreatic	Bos taurus	41-55
1911782-1	1991	Hydrogen exchange has been used to test for the presence of nonrandom structure in thermally denatured ribonuclease A (RNase A).	Hydrogen	0-8	ribonuclease pancreatic	Bos taurus	103-117
1911782-1	1991	Hydrogen exchange has been used to test for the presence of nonrandom structure in thermally denatured ribonuclease A (RNase A).	Hydrogen	0-8	ribonuclease pancreatic	Bos taurus	119-126
1924300-1	1991	Replacing Leu-182 by Ala in yeast alcohol dehydrogenase (YADH; alcohol:NAD+ oxidoreductase, EC 1.1.1.1) yields a mutant that retains 34% of its kcat value and makes one stereochemical "mistake" every 850,000 turnovers (instead of approximately 1 error every 7,000,000,000 turnovers in native YADH) in its selection of the 4-Re hydrogen of NADH.	Hydrogen	44-52	oxidoreductase	Saccharomyces cerevisiae S288C	76-90
1895291-8	1991	The crystallographic structure of the 2-PGA TIM complex shows that the ligand binds fully within the active site of TIM, with partners for all but one of the ligand"s strongly hydrogen bonding groups.	Hydrogen	176-184	triosephosphate isomerase 1	Homo sapiens	44-47
1895291-8	1991	The crystallographic structure of the 2-PGA TIM complex shows that the ligand binds fully within the active site of TIM, with partners for all but one of the ligand"s strongly hydrogen bonding groups.	Hydrogen	176-184	triosephosphate isomerase 1	Homo sapiens	116-119
1936111-2	1991	Plasma renin activity increased from 0.8 +/- 0.1 ng ml-1 h-1 basally to 1.0 +/- 0.2 ng ml-1 h-1 during the 0.5 mU infusion to 1.4 +/- 0.1 ng ml-1 h-1 during the 1 mU infusion but did not change during control infusion (0.9 +/- 0.3 ng ml-1h-1 to 0.9 +/- 0.2 ng ml-1h-1 to 1.0 +/- 0.1 ng ml-1h-1) (P less than 0.001 insulin vs. control by ANOVAR).	Hydrogen	237-239	renin	Homo sapiens	7-12
1651238-4	1991	Here we report the location of the principal polyphosphate binding site on the surface of cytochrome c for both hexametaphosphate and a second polyphosphate, tripolyphosphate determined using 1H-NMR spectroscopy in conjunction with the relaxation probe potassium hexacyanochromium(III).	Hydrogen	192-194	cytochrome c, somatic	Homo sapiens	90-102
1952062-0	1991	1H nuclear magnetic resonance assay of erythrocyte triosephosphate isomerase.	Hydrogen	0-2	triosephosphate isomerase 1	Homo sapiens	51-76
1952062-1	1991	A direct method for measuring the activity of erythrocyte triosephosphate isomerase using 1H NMR spectroscopy was developed.	Hydrogen	90-92	triosephosphate isomerase 1	Homo sapiens	58-83
1936111-2	1991	Plasma renin activity increased from 0.8 +/- 0.1 ng ml-1 h-1 basally to 1.0 +/- 0.2 ng ml-1 h-1 during the 0.5 mU infusion to 1.4 +/- 0.1 ng ml-1 h-1 during the 1 mU infusion but did not change during control infusion (0.9 +/- 0.3 ng ml-1h-1 to 0.9 +/- 0.2 ng ml-1h-1 to 1.0 +/- 0.1 ng ml-1h-1) (P less than 0.001 insulin vs. control by ANOVAR).	Hydrogen	263-265	renin	Homo sapiens	7-12
1936111-2	1991	Plasma renin activity increased from 0.8 +/- 0.1 ng ml-1 h-1 basally to 1.0 +/- 0.2 ng ml-1 h-1 during the 0.5 mU infusion to 1.4 +/- 0.1 ng ml-1 h-1 during the 1 mU infusion but did not change during control infusion (0.9 +/- 0.3 ng ml-1h-1 to 0.9 +/- 0.2 ng ml-1h-1 to 1.0 +/- 0.1 ng ml-1h-1) (P less than 0.001 insulin vs. control by ANOVAR).	Hydrogen	263-265	renin	Homo sapiens	7-12
1856865-5	1991	Additionally, the structure of this complex shows a strong hydrogen bond between the carboxyl group of Glu35 and the beta-anomeric hydroxyl group of the NAM residue in site D. The hydrogen-bonded environment of Asp52 in the native enzyme and in the complex coupled with the very unfavorable direction of approach of the potential carboxylate nucleophile makes it most unlikely that there is a covalent glycosylenzyme intermediate on the hydrolysis pathway of hen egg-white lysozyme.	Hydrogen	59-67	SH3 and cysteine rich domain 3	Homo sapiens	153-156
1856233-4	1991	Tyrosine L32 which hydrogen bonds with ligand was also characterized at the haptenic level through the use of 9-hydroxyphenylfluoron which lacks the carboxyl group to which L32 tyrosine forms a hydrogen bond.	Hydrogen	19-27	ribosomal protein L32	Homo sapiens	9-12
1856233-4	1991	Tyrosine L32 which hydrogen bonds with ligand was also characterized at the haptenic level through the use of 9-hydroxyphenylfluoron which lacks the carboxyl group to which L32 tyrosine forms a hydrogen bond.	Hydrogen	194-202	ribosomal protein L32	Homo sapiens	9-12
1856233-4	1991	Tyrosine L32 which hydrogen bonds with ligand was also characterized at the haptenic level through the use of 9-hydroxyphenylfluoron which lacks the carboxyl group to which L32 tyrosine forms a hydrogen bond.	Hydrogen	194-202	ribosomal protein L32	Homo sapiens	173-176
1856865-5	1991	Additionally, the structure of this complex shows a strong hydrogen bond between the carboxyl group of Glu35 and the beta-anomeric hydroxyl group of the NAM residue in site D. The hydrogen-bonded environment of Asp52 in the native enzyme and in the complex coupled with the very unfavorable direction of approach of the potential carboxylate nucleophile makes it most unlikely that there is a covalent glycosylenzyme intermediate on the hydrolysis pathway of hen egg-white lysozyme.	Hydrogen	59-67	lysozyme	Homo sapiens	473-481
1856865-5	1991	Additionally, the structure of this complex shows a strong hydrogen bond between the carboxyl group of Glu35 and the beta-anomeric hydroxyl group of the NAM residue in site D. The hydrogen-bonded environment of Asp52 in the native enzyme and in the complex coupled with the very unfavorable direction of approach of the potential carboxylate nucleophile makes it most unlikely that there is a covalent glycosylenzyme intermediate on the hydrolysis pathway of hen egg-white lysozyme.	Hydrogen	180-188	SH3 and cysteine rich domain 3	Homo sapiens	153-156
1856865-5	1991	Additionally, the structure of this complex shows a strong hydrogen bond between the carboxyl group of Glu35 and the beta-anomeric hydroxyl group of the NAM residue in site D. The hydrogen-bonded environment of Asp52 in the native enzyme and in the complex coupled with the very unfavorable direction of approach of the potential carboxylate nucleophile makes it most unlikely that there is a covalent glycosylenzyme intermediate on the hydrolysis pathway of hen egg-white lysozyme.	Hydrogen	180-188	lysozyme	Homo sapiens	473-481
2069576-1	1991	We have recorded 1H NMR spectra in H2O for exchangeable protons of four pyridoxal phosphate-dependent enzymes: D-serine dehydratase, aspartate aminotransferase, tryptophan: indole-lyase and glutamate decarboxylase.	Hydrogen	17-19	glutamate-ammonia ligase	Homo sapiens	190-213
2069952-0	1991	Investigation of the solution structure of the human parathyroid hormone fragment (1-34) by 1H NMR spectroscopy, distance geometry, and molecular dynamics calculations.	Hydrogen	92-94	parathyroid hormone	Homo sapiens	53-72
2069952-1	1991	The structure of human parathyroid hormone fragment (1-34) in a solvent mixture of water and trifluoroethanol has been determined by 1H nuclear magnetic resonance spectroscopy and a combination of distance geometry and molecular dynamic simulations.	Hydrogen	133-135	parathyroid hormone	Homo sapiens	23-42
2067016-5	1991	Virtually complete 1H resonance assignments have been obtained for both the (Cd2+)1 and the (Cd2+)2 states.	Hydrogen	19-21	CD22 molecule	Bos taurus	93-99
1904870-2	1991	For subtilisin BPN", a bacterial serine protease, structural data suggest that two hydrogen bonds stabilize the tetrahedral-like oxyanion intermediate: one from the main chain NH of Ser221 and another from the side chain NH2 of Asn155.	Hydrogen	83-91	coagulation factor II, thrombin	Homo sapiens	33-48
1956581-1	1991	Dihydropteridine reductase (DHPR) catalyzes the regeneration of tetrahydrobiopterin (BH4) from quinonoid dihydrobiopterin by using NADH as a hydrogen donor.	Hydrogen	141-149	quinoid dihydropteridine reductase	Homo sapiens	0-26
1956581-1	1991	Dihydropteridine reductase (DHPR) catalyzes the regeneration of tetrahydrobiopterin (BH4) from quinonoid dihydrobiopterin by using NADH as a hydrogen donor.	Hydrogen	141-149	quinoid dihydropteridine reductase	Homo sapiens	28-32
2005096-13	1991	1H NMR spectroscopy revealed Man8GlcNAc2 to be the alpha 1,2-mannosidase-trimming product described earlier (Byrd, J. C., Tarentino, A. L., Maley, F., Atkinson, P. H., and Trimble, R. B.	Hydrogen	0-2	mannosidase alpha class 1A member 2	Homo sapiens	51-72
2050136-1	1991	The solution structure of transforming growth factor alpha has been determined by a combination of high-resolution 1H-nuclear magnetic resonance and distance geometry and restrained molecular dynamics.	Hydrogen	115-117	tumor necrosis factor	Homo sapiens	26-58
2036420-1	1991	The solution structure and dynamics of human insulin are investigated by 2D 1H NMR spectroscopy in reference to a previously analyzed analogue, des-pentapeptide(B26-B30) insulin (DPI; Hua, Q.X., &amp; Weiss, M.A.	Hydrogen	76-78	insulin	Homo sapiens	45-52
2033520-4	1991	By comparing EC50 and the maximum depolarization caused by GTX analogs, the main factors affecting potency were found to be: the formation of 1) electrostatic interaction, 2) a hydrogen bond between groups on the D-ring of GTX and part of the Na channel protein and 3) balance between hydrophilicity and hydrophobicity in the GTX molecule.	Hydrogen	177-185	NK6 homeobox 2	Homo sapiens	59-62
2033520-4	1991	By comparing EC50 and the maximum depolarization caused by GTX analogs, the main factors affecting potency were found to be: the formation of 1) electrostatic interaction, 2) a hydrogen bond between groups on the D-ring of GTX and part of the Na channel protein and 3) balance between hydrophilicity and hydrophobicity in the GTX molecule.	Hydrogen	177-185	NK6 homeobox 2	Homo sapiens	223-226
2033520-4	1991	By comparing EC50 and the maximum depolarization caused by GTX analogs, the main factors affecting potency were found to be: the formation of 1) electrostatic interaction, 2) a hydrogen bond between groups on the D-ring of GTX and part of the Na channel protein and 3) balance between hydrophilicity and hydrophobicity in the GTX molecule.	Hydrogen	177-185	NK6 homeobox 2	Homo sapiens	223-226
2018796-2	1991	Localized edema in the centrilobular region of the liver, following exposure to ethanol and CCl4, was detected by 1H-MRI techniques.	Hydrogen	114-116	C-C motif chemokine ligand 4	Rattus norvegicus	92-96
2015897-1	1991	The solution conformation of a 21-residue vasoconstrictor peptide endothelin-1 (ET-1) in water-ethylene glycol has been determined by two-dimensional 1H-NMR spectroscopy and constrained molecular dynamics simulations.	Hydrogen	150-152	endothelin 1	Homo sapiens	66-78
2015897-1	1991	The solution conformation of a 21-residue vasoconstrictor peptide endothelin-1 (ET-1) in water-ethylene glycol has been determined by two-dimensional 1H-NMR spectroscopy and constrained molecular dynamics simulations.	Hydrogen	150-152	endothelin 1	Homo sapiens	80-84
1654782-9	1991	These results therefore suggest that the interaction of phenolic compounds, presumably by hydrogen-bonding, with the activity limiting distal amino acid residue(s) or with the ferryl oxygen of peroxidase may be an important contributing factor in the enhanced myeloperoxidase-dependent metabolism of hydroquinone in the presence of other phenolic compounds.	Hydrogen	90-98	myeloperoxidase	Homo sapiens	260-275
2007145-0	1991	Porcine pancreatic phospholipase A2: sequence-specific 1H and 15N NMR assignments and secondary structure.	Hydrogen	55-57	phospholipase A2 group IB	Homo sapiens	19-35
2007145-1	1991	The solution structure of porcine pancreatic phospholipase A2 (124 residues, 14 kDa) has been studied by two-dimensional homonuclear 1H and two- and three-dimensional heteronuclear 15N-1H nuclear magnetic resonance spectroscopy.	Hydrogen	185-187	phospholipase A2 group IB	Homo sapiens	45-61
2010918-0	1991	A nuclear magnetic resonance study of the hydrogen-exchange behaviour of lysozyme in crystals and solution.	Hydrogen	42-50	lysozyme	Homo sapiens	73-81
2010918-7	1991	Hydrogen exchange was also monitored in both tetragonal and triclinic crystals of lysozyme, by allowing exchange to take place in the crystals prior to dissolution and recording of n.m.r.	Hydrogen	0-8	lysozyme	Homo sapiens	82-90
1646718-0	1991	EPR and 1H-NMR spectroscopic studies on the paramagnetic iron at the active site of phenylalanine hydroxylase and its interaction with substrates and inhibitors.	Hydrogen	8-10	phenylalanine hydroxylase	Bos taurus	84-109
1646718-1	1991	The paramagnetic iron at the active site of highly purified, catalytically active phenylalanine hydroxylase was studied by EPR at 3.6 K and one-dimensional 1H-NMR spectroscopy at 293 K. The EPR-detectable iron of the bovine enzyme was found to be present as a high-spin form (S = 5/2) in different ligand field symmetries depending on medium conditions (buffer ions) and the presence of ligands known to bind at the active site.	Hydrogen	156-158	phenylalanine hydroxylase	Bos taurus	82-107
1889390-6	1991	These results suggest that a hydrophilic interaction, such as hydrogen bond or van der Waals interaction, plays an important role in the binding of plasma fibronectin to gelatin.	Hydrogen	62-70	fibronectin 1	Homo sapiens	155-166
1851482-0	1991	Assignment of active-site protons in the 1H-NMR spectrum of reduced human Cu/Zn superoxide dismutase.	Hydrogen	41-43	superoxide dismutase 1	Homo sapiens	74-100
1852113-4	1991	Corynanthine pretreatment attenuated the vasopressin response to H2 in males, potentiated this response in proestrous females, but had no effect in estrous females.	Hydrogen	65-67	arginine vasopressin	Rattus norvegicus	41-52
1820763-2	1991	It is suggested that each activator is hydrogen-bonded to sulfhydryl groups of cysteine residues and to the carbonyl of an asparagine within the cysteine-rich regions of PKC.	Hydrogen	39-47	proline rich transmembrane protein 2	Homo sapiens	170-173
2018758-0	1991	1H NMR identification of a beta-sheet structure and description of folding topology in putidaredoxin.	Hydrogen	0-2	amyloid beta precursor protein	Homo sapiens	25-31
1901789-2	1991	A recombinant 90-residue polypeptide fragment containing the three-loop kringle-2 domain of human tissue-type plasminogen activator (t-PA) has been studied by two-dimensional 1H-NMR spectroscopy at 500 MHz.	Hydrogen	175-177	plasminogen activator, tissue type	Homo sapiens	98-131
1850488-11	1991	ACTH, cortisol, and AVP responses were promptly attenuated in the HS group, but remained greater than control.	Hydrogen	66-68	proopiomelanocortin	Canis lupus familiaris	0-4
2039611-2	1991	The indole NH group is hydrogen bonded to the amide oxygen, O15" (related by chi, 0.5 -y, -0.5 + z), of the indolizine moiety with relevant parameters: N...O 2.79 (2)A, H...O 2.02 (15) A, N-H...O 145 (14) degrees.	Hydrogen	23-31	immunoglobulin kappa variable 2-36 (pseudogene)	Homo sapiens	60-63
1900207-6	1991	This stereoselective hydrogen removal conforms to the properties of an 8S-lipoxygenase.	Hydrogen	21-29	arachidonate 8-lipoxygenase	Mus musculus	71-86
1847303-3	1991	In addition, the 31P-NMR spectrum indicated rather high levels of UDPG, a finding confirmed by 1H-NMR spectra of perchloric acid extracts.	Hydrogen	95-97	UDP-glucose pyrophosphorylase 2	Homo sapiens	66-70
2018499-0	1991	1H NMR resonance assignments in a paramagnetic heme protein by two-dimensional spectroscopy: heme resonances in equine met-azido myoglobin.	Hydrogen	0-2	myoglobin	Equus caballus	129-138
2018499-1	1991	Specific heme protons for the majority of resonances in the downfield resolved region of equine met-azido myoglobin have been assigned using solely the two-dimensional 1H NMR experiments NOESY and COSY.	Hydrogen	168-170	myoglobin	Equus caballus	106-115
1901038-0	1991	Chemical modification and 1H-NMR studies on the receptor-binding region of human interleukin 6.	Hydrogen	26-28	interleukin 6	Homo sapiens	81-94
1869369-0	1991	Solution conformation of endothelin-1 by 1H NMR, CD, and molecular modeling.	Hydrogen	41-43	endothelin 1	Homo sapiens	25-37
1869369-1	1991	The solution conformation of Endothelin-1, a recently discovered bicyclic, 21 amino acid peptide, has been examined by 1H NMR in deuterated dimethylsulphoxide and circular dichroism in aqueous and organic solvents.	Hydrogen	119-121	endothelin 1	Homo sapiens	29-41
2000138-5	1991	For alpha-lactalbumin, hydrogen exchange kinetics monitored by NMR proved to be crucial for identifying native-like structural features in the stable molten globule state.	Hydrogen	23-31	lactalbumin alpha	Homo sapiens	4-21
1991117-14	1991	The berenil molecule binds at the 5"-AAT (identical to 5"-ATT on the complementary strand) site such that (i) favorable hydrogen bonds are formed between the charged amidinium groups and the N3 atoms of Ado 6 and Ado 18 and (ii) the ligand is closely isohelical with the floor of the minor groove.	Hydrogen	120-128	serpin family A member 1	Homo sapiens	37-40
1991121-10	1991	The energy-minimized conformation of the central d(A6-oxo-G7-T8).d(A17-A18-T19) segment requires that the 8-oxo-7H-dG7(syn).dA18(anti) alignment be stabilized by two hydrogen bonds from NH7 and O6 of 8-oxo-7H-dG7(syn) to N1 and NH2-6 of dA18(anti), respectively, at the lesion site.	Hydrogen	166-174	a6	Drosophila melanogaster	51-53
1991121-10	1991	The energy-minimized conformation of the central d(A6-oxo-G7-T8).d(A17-A18-T19) segment requires that the 8-oxo-7H-dG7(syn).dA18(anti) alignment be stabilized by two hydrogen bonds from NH7 and O6 of 8-oxo-7H-dG7(syn) to N1 and NH2-6 of dA18(anti), respectively, at the lesion site.	Hydrogen	166-174	broad	Drosophila melanogaster	71-74
1991121-10	1991	The energy-minimized conformation of the central d(A6-oxo-G7-T8).d(A17-A18-T19) segment requires that the 8-oxo-7H-dG7(syn).dA18(anti) alignment be stabilized by two hydrogen bonds from NH7 and O6 of 8-oxo-7H-dG7(syn) to N1 and NH2-6 of dA18(anti), respectively, at the lesion site.	Hydrogen	166-174	broad	Drosophila melanogaster	124-128
1991121-10	1991	The energy-minimized conformation of the central d(A6-oxo-G7-T8).d(A17-A18-T19) segment requires that the 8-oxo-7H-dG7(syn).dA18(anti) alignment be stabilized by two hydrogen bonds from NH7 and O6 of 8-oxo-7H-dG7(syn) to N1 and NH2-6 of dA18(anti), respectively, at the lesion site.	Hydrogen	166-174	broad	Drosophila melanogaster	237-241
1989688-0	1991	Analysis of phi and chi 1 torsion angles for hen lysozyme in solution from 1H NMR spin-spin coupling constants.	Hydrogen	75-77	lysozyme	Homo sapiens	49-57
1988044-1	1991	The structure of human calcitonin gene-related peptide 1 (hCGRP-1) has been determined by 1H NMR in a mixed-solvent system of 50% trifluoroethanol/50% H2O at pH 3.7 and 27 degrees C. Complete resonance assignment was achieved by using two-dimensional methods.	Hydrogen	90-92	calcitonin related polypeptide alpha	Homo sapiens	23-56
1988044-1	1991	The structure of human calcitonin gene-related peptide 1 (hCGRP-1) has been determined by 1H NMR in a mixed-solvent system of 50% trifluoroethanol/50% H2O at pH 3.7 and 27 degrees C. Complete resonance assignment was achieved by using two-dimensional methods.	Hydrogen	90-92	calcitonin related polypeptide alpha	Homo sapiens	58-65
1725379-6	1991	In a second series using hydrogen clearance technique for measurement of local cerebral blood flow in the caudate nucleus, we have shown that flow ipsilateral to application of ET-1 (0.25 nmol) is significantly reduced compared with saline controls for 80 min.	Hydrogen	25-33	endothelin 1	Rattus norvegicus	177-181
1993480-2	1991	The solution structure of endothelin-1, a newly discovered potent bicyclic peptide vaso-constrictor agent, has been investigated using 1H NMR conformational constraints and distance geometry calculations.	Hydrogen	135-137	endothelin 1	Homo sapiens	26-38
1988016-0	1991	1H resonance assignment and secondary structure determination of the dimerization domain of transcription factor LFB1.	Hydrogen	0-2	HNF1 homeobox A	Homo sapiens	113-117
1793509-2	1991	The rate of hydrolysis was subject to apparent specific acid catalysis, the specific hydrogen ion catalytic rate constant being 4.9 x 10(-2) M-1 min-1 at 80 degrees C and mu = 0.5.	Hydrogen	85-93	myoregulin	Homo sapiens	141-150
1663899-8	1991	Cytochrome c not only introduces an artifact when determining PI, but is also may act as a hydrogen donor for CCP when monitoring H2O2 formation, thus decreasing the sensitivity of this method.	Hydrogen	91-99	cytochrome c, somatic	Homo sapiens	0-12
2014028-5	1991	Half-lives were calculated from the mean values of all experiments by a two-compartment system; INT-PTH: 11.1 +/- 3.9 min, HS-PTH: 9.6 +/- 1.7 hrs., MM-PTH: 11.1 +/- 2.9 hrs., C-PTH: 10.1 +/- 1.2 hrs.	Hydrogen	123-125	parathyroid hormone	Homo sapiens	126-129
2269352-7	1990	This positioning facilitates the compensatory hydrogen bonding between solvent and residues P-3 and P-4 (relative to proline, P), through the formation of the kink.	Hydrogen	46-54	solute carrier family 10 member 3	Homo sapiens	92-95
2014028-5	1991	Half-lives were calculated from the mean values of all experiments by a two-compartment system; INT-PTH: 11.1 +/- 3.9 min, HS-PTH: 9.6 +/- 1.7 hrs., MM-PTH: 11.1 +/- 2.9 hrs., C-PTH: 10.1 +/- 1.2 hrs.	Hydrogen	123-125	parathyroid hormone	Homo sapiens	126-129
2014028-5	1991	Half-lives were calculated from the mean values of all experiments by a two-compartment system; INT-PTH: 11.1 +/- 3.9 min, HS-PTH: 9.6 +/- 1.7 hrs., MM-PTH: 11.1 +/- 2.9 hrs., C-PTH: 10.1 +/- 1.2 hrs.	Hydrogen	123-125	parathyroid hormone	Homo sapiens	126-129
2271664-0	1990	Toward the solution structure of human insulin: sequential 2D 1H NMR assignment of a des-pentapeptide analogue and comparison with crystal structure.	Hydrogen	62-64	insulin	Homo sapiens	39-46
2268669-1	1990	Partial assignments for the 1H-NMR resonances of the aromatic residues in human interleukin 6 (IL-6) are reported.	Hydrogen	28-30	interleukin 6	Homo sapiens	80-93
2268669-1	1990	Partial assignments for the 1H-NMR resonances of the aromatic residues in human interleukin 6 (IL-6) are reported.	Hydrogen	28-30	interleukin 6	Homo sapiens	95-99
2075195-1	1990	In the active centre of pancreatic phospholipase A2 His48 is at hydrogen-bonding distance to Asp99.	Hydrogen	64-72	phospholipase A2 group IB	Homo sapiens	35-51
2265195-0	1990	31P- and 1H-NMR investigations of the effect of n-alcohols on the hydrolysis by phospholipase A2 of phospholipid vesicular membranes.	Hydrogen	9-11	phospholipase A2 group IB	Homo sapiens	80-96
2226430-3	1990	31P- and 1H-NMR spectra showed significant differences between cls11 and wild-type cells at the level of amino acids, the storage carbohydrate trehalose (higher in mutant cells), and sugar phosphates (higher in wild-type cells).	Hydrogen	9-11	H(+)-transporting V1 sector ATPase subunit H	Saccharomyces cerevisiae S288C	63-68
2241171-6	1990	In addition, the data of FAB-MS and 1H NMR suggested that the unknown residues (modified histidine) within AGT-1 and AGT-2 should have the 2-imidazolone structure.	Hydrogen	36-38	alanine--glyoxylate aminotransferase 2	Homo sapiens	117-122
2078191-0	1990	2D 1H NMR studies of monomeric insulin.	Hydrogen	3-5	insulin	Homo sapiens	31-38
2226459-0	1990	Effect of the tyrosine 96 hydrogen bond on the inactivation of cytochrome P-450cam induced by hydrostatic pressure.	Hydrogen	26-34	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-79
2172341-1	1990	Neutrophil myeloperoxidase (MPO) adsorbs to bacteria as a pre-requisite for killing by the MPO/hydrogen-peroxide/chloride system.	Hydrogen	95-103	myeloperoxidase	Homo sapiens	11-26
2172341-1	1990	Neutrophil myeloperoxidase (MPO) adsorbs to bacteria as a pre-requisite for killing by the MPO/hydrogen-peroxide/chloride system.	Hydrogen	95-103	myeloperoxidase	Homo sapiens	28-31
2172341-1	1990	Neutrophil myeloperoxidase (MPO) adsorbs to bacteria as a pre-requisite for killing by the MPO/hydrogen-peroxide/chloride system.	Hydrogen	95-103	myeloperoxidase	Homo sapiens	91-94
2252901-6	1990	In the 1H NMR spectrum of proinsulin significant variation is observed in the line widths of insulin-specific amide resonances, reflecting exchange among conformational substates; similar exchange is observed in insulin and is not damped by the connecting peptide.	Hydrogen	7-9	insulin	Homo sapiens	26-36
2170130-1	1990	The association of the tryptic fragment of bovine microsomal cytochrome b5 with cytochrome c has been studied by one- and two-dimensional 1H-NMR spectroscopy.	Hydrogen	138-140	cytochrome b5 type A	Bos taurus	61-74
2290835-6	1990	The orientation of histidine residues is usually stabilized through hydrogen bonding; ND1-protonated form of a helical residue can form a hydrogen bond with the carbonyl oxygen atom in the preceding turn of the helix.	Hydrogen	68-76	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	86-89
2290835-6	1990	The orientation of histidine residues is usually stabilized through hydrogen bonding; ND1-protonated form of a helical residue can form a hydrogen bond with the carbonyl oxygen atom in the preceding turn of the helix.	Hydrogen	138-146	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	86-89
2171514-0	1990	Tyrosinate fluorescence lifetimes for oxytocin and vasopressin in receptor-simulating environments: relationship to biological activity and 1H-NMR data.	Hydrogen	140-142	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	38-46
2171514-0	1990	Tyrosinate fluorescence lifetimes for oxytocin and vasopressin in receptor-simulating environments: relationship to biological activity and 1H-NMR data.	Hydrogen	140-142	arginine vasopressin	Rattus norvegicus	51-62
2171514-2	1990	Long-lifetime tyrosinate fluorescence (LTF), characteristic of stable intramolecular hydrogen bond formation of the Tyr hydroxyl group, was present for OXT but not AVP in propylene glycol.	Hydrogen	85-93	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	152-155
2171514-4	1990	The spectroscopic data illustrate that the Tyr hydroxyl in OXT participates in an intramolecular hydrogen bond in certain receptor-simulating environments; the absence of potent LTF for [Ala5] OXT suggests that the Tyr hydroxyl of OXT forms an H-bond with the Asn5 carboxamide side-chain.	Hydrogen	97-105	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	59-62
2252901-7	1990	The aromatic 1H NMR resonances of proinsulin are assigned by analogy to the spectrum of insulin, and assignments are verified by chemical modification.	Hydrogen	13-15	insulin	Homo sapiens	34-44
2252901-7	1990	The aromatic 1H NMR resonances of proinsulin are assigned by analogy to the spectrum of insulin, and assignments are verified by chemical modification.	Hydrogen	13-15	insulin	Homo sapiens	37-44
2252901-6	1990	In the 1H NMR spectrum of proinsulin significant variation is observed in the line widths of insulin-specific amide resonances, reflecting exchange among conformational substates; similar exchange is observed in insulin and is not damped by the connecting peptide.	Hydrogen	7-9	insulin	Homo sapiens	29-36
2252901-6	1990	In the 1H NMR spectrum of proinsulin significant variation is observed in the line widths of insulin-specific amide resonances, reflecting exchange among conformational substates; similar exchange is observed in insulin and is not damped by the connecting peptide.	Hydrogen	7-9	insulin	Homo sapiens	93-100
2261437-0	1990	Solution structures of human transforming growth factor alpha derived from 1H NMR data.	Hydrogen	75-77	tumor necrosis factor	Homo sapiens	29-61
2261471-0	1990	Assignment of the side-chain 1H and 13C resonances of interleukin-1 beta using double- and triple-resonance heteronuclear three-dimensional NMR spectroscopy.	Hydrogen	29-31	interleukin 1 beta	Homo sapiens	54-72
2261471-1	1990	The assignment of the aliphatic 1H and 13C resonances of IL-1 beta, a protein of 153 residues and molecular mass 17.4 kDa, is presented by use of a number of novel three-dimensional (3D) heteronuclear NMR experiments which rely on large heteronuclear one-bond J couplings to transfer magnetization and establish through-bond connectivities.	Hydrogen	32-34	interleukin 1 beta	Homo sapiens	57-66
2146972-11	1990	In addition, the enzyme is B-side specific, catalyzing the transfer of the 4B-hydrogen from the dihydronicotinamide moiety of the cofactor, for both C-18 and C-21 steroid substrates.	Hydrogen	78-86	Bardet-Biedl syndrome 9	Homo sapiens	149-153
2146972-11	1990	In addition, the enzyme is B-side specific, catalyzing the transfer of the 4B-hydrogen from the dihydronicotinamide moiety of the cofactor, for both C-18 and C-21 steroid substrates.	Hydrogen	78-86	TBL1X/Y related 1	Homo sapiens	158-162
2261466-0	1990	1H NMR assignment and secondary structure of the Ca2(+)-free form of the amino-terminal epidermal growth factor like domain in coagulation factor X.	Hydrogen	0-2	coagulation factor X	Mus musculus	127-147
2261438-3	1990	By use of a combination of two-dimensional NMR techniques, the 1H NMR spectrum of thymosin beta 4 is assigned.	Hydrogen	63-65	thymosin beta 4 X-linked	Homo sapiens	82-97
2261437-1	1990	The 600-MHz 1H NMR spectrum of the des-Val-Val mutant of human transforming growth factor alpha (TGF-alpha) was reassigned at pH = 6.3.	Hydrogen	12-14	tumor necrosis factor	Homo sapiens	63-95
2388269-0	1990	Low resolution structure of interleukin-1 beta in solution derived from 1H-15N heteronuclear three-dimensional nuclear magnetic resonance spectroscopy.	Hydrogen	72-74	interleukin 1 beta	Homo sapiens	28-46
2388269-1	1990	A low resolution solution structure of the cytokine interleukin-1 beta, a 153 residue protein of molecular weight 17,400, has been determined on the basis of 446 nuclear Overhauser effect (NOE) derived approximate interproton distance restraints involving solely NH, C alpha H and C beta H protons, supplemented by 90 distance restraints for 45 hydrogen bonds, and 79 phi torsion angle restraints.	Hydrogen	345-353	interleukin 1 beta	Homo sapiens	52-70
2384166-5	1990	We propose that at high NaF concentrations, 3 hydrogen-bonded fluorides in the gamma-phosphate site of T alpha GDP entrap a magnesium counterion and this induces the transconformation to the T alpha GTP form.	Hydrogen	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
2223770-0	1990	Analysis of the backbone dynamics of interleukin-1 beta using two-dimensional inverse detected heteronuclear 15N-1H NMR spectroscopy.	Hydrogen	113-115	interleukin 1 beta	Homo sapiens	37-55
2223770-1	1990	The backbone dynamics of uniformly 15N-labeled interleukin-1 beta are investigated by using two-dimensional inverse detected heteronuclear 15N-1H NMR spectroscopy.	Hydrogen	143-145	interleukin 1 beta	Homo sapiens	47-65
2390059-5	1990	The delta S++ for dissociation was negative, and the enthalpy of activation for dissociation was about 20.3 kJ.mol-1 larger than that for association, indicating that the PRL-receptor complex is further stabilized by contributions of hydrogen bonds and van der Waals contacts after the initial interaction.	Hydrogen	234-242	prolactin	Oryctolagus cuniculus	171-174
2167380-1	1990	In human metallothionein-2, the exchange rate constants of ten amide protons were found to range from 1.7 x 10(-4) to 1 x 10(-1) min-1 at pH 6.3 and 8 degrees C. Most of these slowly exchanging protons could be associated with hydrogen bonds in secondary structure elements of the alpha-domain.	Hydrogen	227-235	CD59 molecule (CD59 blood group)	Homo sapiens	129-134
2199196-2	1990	The shortened analogue of insulin, des-(B26-B30)-pentapeptide insulin, has been characterized by two-dimensional 1H NMR.	Hydrogen	113-115	insulin	Homo sapiens	26-33
2199196-2	1990	The shortened analogue of insulin, des-(B26-B30)-pentapeptide insulin, has been characterized by two-dimensional 1H NMR.	Hydrogen	113-115	insulin	Homo sapiens	62-69
2374926-3	1990	Residues Ile1 to Tyr3 of hirudin form a parallel beta-strand with Ser214 to Glu217 of thrombin with the nitrogen atom of Ile1 making a hydrogen bond with Ser195 O gamma atom of the catalytic site, but the specificity pocket of thrombin is not involved in the interaction.	Hydrogen	135-143	coagulation factor II, thrombin	Homo sapiens	86-94
2230716-4	1990	1H NMR analysis showed that both kinds of mannan contained alpha-1,2 and beta-1,2 linkages.	Hydrogen	0-2	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	73-81
2374926-3	1990	Residues Ile1 to Tyr3 of hirudin form a parallel beta-strand with Ser214 to Glu217 of thrombin with the nitrogen atom of Ile1 making a hydrogen bond with Ser195 O gamma atom of the catalytic site, but the specificity pocket of thrombin is not involved in the interaction.	Hydrogen	135-143	coagulation factor II, thrombin	Homo sapiens	227-235
2164789-1	1990	H(+)-K(+)-ATPase and carbonic anhydrase II (CA II) are two enzymes that are involved in the production and secretion of the hydrogen ion by the gastric parietal cell and maintenance of intracellular pH therein.	Hydrogen	124-132	carbonic anhydrase 2	Rattus norvegicus	21-42
2164789-1	1990	H(+)-K(+)-ATPase and carbonic anhydrase II (CA II) are two enzymes that are involved in the production and secretion of the hydrogen ion by the gastric parietal cell and maintenance of intracellular pH therein.	Hydrogen	124-132	carbonic anhydrase 2	Rattus norvegicus	44-49
9903857-0	1990	Effects of alignment and interference in resonant transfer and excitation for F6+ and O5+ collisions with H2 in 0 degrees Auger measurements.	Hydrogen	106-108	ATP synthase peripheral stalk subunit F6	Homo sapiens	78-88
2391767-0	1990	A 1H-NMR comparison of calmodulin activation by calcium and by cadmium.	Hydrogen	2-4	calmodulin	Bos taurus	23-33
2383553-0	1990	Identification and localization of bound internal water in the solution structure of interleukin 1 beta by heteronuclear three-dimensional 1H rotating-frame Overhauser 15N-1H multiple quantum coherence NMR spectroscopy.	Hydrogen	139-141	interleukin 1 beta	Homo sapiens	85-103
2166565-0	1990	Ca2+ binding to calbindin D9k strongly affects backbone dynamics: measurements of exchange rates of individual amide protons using 1H NMR.	Hydrogen	131-133	S100 calcium binding protein G	Homo sapiens	16-29
2383553-0	1990	Identification and localization of bound internal water in the solution structure of interleukin 1 beta by heteronuclear three-dimensional 1H rotating-frame Overhauser 15N-1H multiple quantum coherence NMR spectroscopy.	Hydrogen	172-174	interleukin 1 beta	Homo sapiens	85-103
2383553-1	1990	The presence and location of bound internal water molecules in the solution structure of interleukin 1 beta have been investigated by means of three-dimensional 1H rotating-frame Overhauser 1H-15N multiple quantum coherence spectroscopy (ROESY-HMQC).	Hydrogen	161-163	interleukin 1 beta	Homo sapiens	89-107
2359115-1	1990	The solution structure of apo calbindin D9K, a member of the calmodulin superfamily of calcium-binding regulatory proteins, has been investigated by 1H nuclear magnetic resonance spectroscopy and the results compared with a corresponding study of the calcium-loaded protein.	Hydrogen	149-151	S100 calcium binding protein G	Homo sapiens	30-43
2383553-1	1990	The presence and location of bound internal water molecules in the solution structure of interleukin 1 beta have been investigated by means of three-dimensional 1H rotating-frame Overhauser 1H-15N multiple quantum coherence spectroscopy (ROESY-HMQC).	Hydrogen	190-192	interleukin 1 beta	Homo sapiens	89-107
2383553-4	1990	By this means, the problems that prevent, in all but a very few limited cases, the interpretation, identification, and assignment of ROE peaks between NH protons and water in a 2D 1H-1H ROESY spectrum of a large protein such as interleukin 1 beta, namely, extensive NH chemical shift degeneracy and ROE peaks obscured by much stronger chemical exchange peaks, are completely circumvented.	Hydrogen	180-182	interleukin 1 beta	Homo sapiens	228-246
2383553-4	1990	By this means, the problems that prevent, in all but a very few limited cases, the interpretation, identification, and assignment of ROE peaks between NH protons and water in a 2D 1H-1H ROESY spectrum of a large protein such as interleukin 1 beta, namely, extensive NH chemical shift degeneracy and ROE peaks obscured by much stronger chemical exchange peaks, are completely circumvented.	Hydrogen	183-185	interleukin 1 beta	Homo sapiens	228-246
2383553-8	1990	209, 779-791], the results can be attributed to 11 water molecules that are involved in interactions bridging hydrogen-bonding interactions with backbone amide and carbonyl groups which stabilize the 3-fold pseudosymmetric topology of interleukin 1 beta and thus constitute an integral part of the protein structure in solution.	Hydrogen	110-118	interleukin 1 beta	Homo sapiens	235-253
1694115-0	1990	Unique structure of glycopeptide from alpha-fetoprotein produced in human hepatoma cell line, as determined by 1H-nuclear magnetic resonance spectroscopy.	Hydrogen	111-113	alpha fetoprotein	Homo sapiens	38-55
2194578-0	1990	Sequence-specific 1H-NMR assignments for the aromatic region of several biologically active, monomeric insulins including native human insulin.	Hydrogen	18-20	insulin	Homo sapiens	103-110
2194578-1	1990	The aromatic region of the 1H-FT-NMR spectrum of the biologically fully-potent, monomeric human insulin mutant, B9 Ser----Asp, B27 Thr----Glu has been investigated in D2O.	Hydrogen	27-29	insulin	Homo sapiens	96-103
2365059-4	1990	An intramolecular hydrogen bond between purine ring substituents is detected in the X-ray structure and may be an important structural feature of sangivamycin related to its degree of inhibition of rhodopsin kinase and of protein kinases C and A.	Hydrogen	18-26	G protein-coupled receptor kinase 7	Homo sapiens	198-214
2166134-3	1990	1H NMR spectra on the cobalt substituted PEG-modified SOD, Cu2Co2-PEG-SOD, have been recorded.	Hydrogen	0-2	superoxide dismutase 1	Homo sapiens	54-57
2166134-3	1990	1H NMR spectra on the cobalt substituted PEG-modified SOD, Cu2Co2-PEG-SOD, have been recorded.	Hydrogen	0-2	superoxide dismutase 1	Homo sapiens	70-73
2166134-6	1990	The analysis has shown that the histidine hydrogens involved in metal binding at the enzyme active site are the same in both native and PEG-modified SOD.	Hydrogen	42-51	superoxide dismutase 1	Homo sapiens	149-152
2372550-0	1990	Determination of the secondary structure and molecular topology of interleukin-1 beta by use of two- and three-dimensional heteronuclear 15N-1H NMR spectroscopy.	Hydrogen	141-143	interleukin 1 beta	Homo sapiens	67-85
2187994-0	1990	Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site.	Hydrogen	83-91	renin	Homo sapiens	29-34
2187994-2	1990	Molecular modeling suggests that the heterocyclic oxygen hydrogen bonds as an acceptor to the flap region of renin and that the second hydroxyl in the glycol-based inhibitors behaves similarly.	Hydrogen	57-65	renin	Homo sapiens	109-114
2342109-1	1990	An equation for calculating the distances between the atoms involved in forming an idealized hydrogen bond in a parallel or antiparallel beta-barrel has been derived by adjusting the corresponding data given by Pauling and Corey for a beta-sheet.	Hydrogen	93-101	amyloid beta precursor protein	Homo sapiens	233-239
2156832-3	1990	cAMP specificity is conferred by hydrogen bonding at the N-6 and N-7 positions.	Hydrogen	33-41	cathelicidin antimicrobial peptide	Cricetulus griseus	0-4
2339118-3	1990	We have used a HeLa cell-free system in which HSF DNA-binding is activated by conditions that affect protein conformation, including increasing concentrations of hydrogen ions, urea, or nonionic detergents.	Hydrogen	162-170	interleukin 6	Homo sapiens	46-49
2108140-0	1990	1H NMR spectrum of the native human insulin monomer.	Hydrogen	0-2	insulin	Homo sapiens	36-43
2108140-2	1990	The effects of high dilution on the 1H Fourier transform NMR spectrum of native human insulin at pH* 8.0 and 9.3 have been examined at 500 MHz resolution.	Hydrogen	36-38	insulin	Homo sapiens	86-93
2108140-4	1990	Under these conditions of dilution, ionic strength, and pH*, human insulin and the SerB9----Asp mutant exhibit nearly identical 1H NMR spectra.	Hydrogen	128-130	insulin	Homo sapiens	67-74
2207181-1	1990	The life-time of excited h-b-1 hydrogen bond in paired guanine-cytosine bases].	Hydrogen	31-39	HBN1	Homo sapiens	25-30
2184238-2	1990	In an effort to decrease the size and to increase the hydrophilicity of the previously prepared renin inhibitory peptides, it was postulated that one might be able to take advantage of the polar Thr-84 on the flap region of the enzyme renin by potential hydrogen bonding to polar functionality on the inhibitory peptide at the P-2 site.	Hydrogen	254-262	renin	Homo sapiens	96-101
2184238-2	1990	In an effort to decrease the size and to increase the hydrophilicity of the previously prepared renin inhibitory peptides, it was postulated that one might be able to take advantage of the polar Thr-84 on the flap region of the enzyme renin by potential hydrogen bonding to polar functionality on the inhibitory peptide at the P-2 site.	Hydrogen	254-262	renin	Homo sapiens	235-240
2354151-1	1990	The complete sequence-specific assignment of the 15N and 1H backbone resonances of the NMR spectrum of recombinant human interleukin 1 beta (153 residues, Mr = 17,400) has been obtained by using primarily 15N-1H heteronuclear three-dimensional (3D) NMR techniques in combination with 15N-1H heteronuclear and 1H homonuclear two-dimensional NMR.	Hydrogen	57-59	interleukin 1 beta	Homo sapiens	121-139
2354151-1	1990	The complete sequence-specific assignment of the 15N and 1H backbone resonances of the NMR spectrum of recombinant human interleukin 1 beta (153 residues, Mr = 17,400) has been obtained by using primarily 15N-1H heteronuclear three-dimensional (3D) NMR techniques in combination with 15N-1H heteronuclear and 1H homonuclear two-dimensional NMR.	Hydrogen	209-211	interleukin 1 beta	Homo sapiens	121-139
2354151-1	1990	The complete sequence-specific assignment of the 15N and 1H backbone resonances of the NMR spectrum of recombinant human interleukin 1 beta (153 residues, Mr = 17,400) has been obtained by using primarily 15N-1H heteronuclear three-dimensional (3D) NMR techniques in combination with 15N-1H heteronuclear and 1H homonuclear two-dimensional NMR.	Hydrogen	209-211	interleukin 1 beta	Homo sapiens	121-139
2354151-1	1990	The complete sequence-specific assignment of the 15N and 1H backbone resonances of the NMR spectrum of recombinant human interleukin 1 beta (153 residues, Mr = 17,400) has been obtained by using primarily 15N-1H heteronuclear three-dimensional (3D) NMR techniques in combination with 15N-1H heteronuclear and 1H homonuclear two-dimensional NMR.	Hydrogen	209-211	interleukin 1 beta	Homo sapiens	121-139
2323343-5	1990	At one end of the drug the amidinium group is in hydrogen-bonded contact with N3 of the adenine base complementary to the thymine of the AAT.	Hydrogen	49-57	serpin family A member 1	Homo sapiens	137-140
2334691-0	1990	1H NMR sequential assignments and secondary structure analysis of human fibrinogen gamma-chain C-terminal residues 385-411.	Hydrogen	0-2	fibrinogen gamma chain	Homo sapiens	72-94
2334691-2	1990	This peptide was isolated from cyanogen bromide degraded human fibrinogen and was investigated by 1H NMR (500 MHz) spectroscopy.	Hydrogen	98-100	fibrinogen beta chain	Homo sapiens	63-73
2320585-0	1990	Solution conformations of the B-loop fragments of human transforming growth factor alpha and epidermal growth factor by 1H nuclear magnetic resonance and restrained molecular dynamics.	Hydrogen	120-122	tumor necrosis factor	Homo sapiens	56-88
2186804-0	1990	Complete sequence-specific 1H NMR assignments for human insulin.	Hydrogen	27-29	insulin	Homo sapiens	56-63
2154181-5	1990	From the phospholipid-induced changes of the protein spectral features it is concluded that the first 2 equivalents of cardiolipin cause a conformational change at the lower part of the solvent-exposed haem edge, involving a rearrangement of the hydrogen-bond interactions of propionate 6, thus partly accounting for the lowered redox potential of cytochrome c in the presence of cardiolipin.	Hydrogen	246-254	cytochrome c, somatic	Homo sapiens	348-360
2186807-7	1990	Molecular modeling indicates the substrate histidine could hydrogen bond to Asp-226 of the enzyme (renin numbering), thus perturbing the ionization of the catalytic aspartyl groups (Asp-38 and Asp-226).	Hydrogen	59-67	renin	Homo sapiens	99-104
2331517-2	1990	The substructural units, 5-14 linear and 5-14 cyclic, have been used as models for MCH-- H-Asp1-Thr-Met-Arg-Cys-Met-Val-Gly-Arg HO-Val17-Glu-Trp-Cys-Pro-Arg-Tyr-Val in 1H-nmr conformational studies.	Hydrogen	168-170	pro-melanin concentrating hormone	Homo sapiens	83-86
2334702-9	1990	We propose that the energetically stressed native alpha 1-AT structure is the consequence of a significantly reduced number of hydrogen bonds in secondary structure components and that reactive-site cleavage between Met358 and Ser359 is the key for the development of the fully hydrogen bonded more stable serpin structure.	Hydrogen	127-135	serpin family A member 1	Homo sapiens	50-60
2334702-9	1990	We propose that the energetically stressed native alpha 1-AT structure is the consequence of a significantly reduced number of hydrogen bonds in secondary structure components and that reactive-site cleavage between Met358 and Ser359 is the key for the development of the fully hydrogen bonded more stable serpin structure.	Hydrogen	278-286	serpin family A member 1	Homo sapiens	50-60
16348146-5	1990	Kinetic analysis gave, for hydrogen inhibition, K(p(H(2))) = 0.11 atm (= 11.1 kPa, 71.5 muM), q(m) = 2.40 mmol/g of MLVSS per day, and n = 1.51 and, for acetate inhibition, K(p(HAc)) = 48.6 muM, q(m) = 1.85 mmol/g of MLVSS per day, and n = 0.96.	Hydrogen	27-35	latexin	Homo sapiens	88-91
16348146-5	1990	Kinetic analysis gave, for hydrogen inhibition, K(p(H(2))) = 0.11 atm (= 11.1 kPa, 71.5 muM), q(m) = 2.40 mmol/g of MLVSS per day, and n = 1.51 and, for acetate inhibition, K(p(HAc)) = 48.6 muM, q(m) = 1.85 mmol/g of MLVSS per day, and n = 0.96.	Hydrogen	27-35	latexin	Homo sapiens	190-193
2188741-2	1990	After 1h incubation with insulin there was a higher proportion of polysomes in the cytoskeletal fraction with a decrease occurring in the membrane-bound fraction.	Hydrogen	6-8	insulin	Homo sapiens	25-32
2154849-1	1990	The complex formed in solution by native and chemically modified cytochrome c with cytochrome b5 has been studied by 1H and 13C nuclear magnetic resonance spectroscopy (NMR).	Hydrogen	117-119	cytochrome c, somatic	Homo sapiens	65-77
2154849-4	1990	As individual cytochrome c lysyl residues are resolved in the 1H NMR spectrum of N-acetimidylated cytochrome c, the interaction of this modified protein with cytochrome b5 has been studied to evaluate the number of cytochrome c lysyl residues involved in binding to cytochrome b5.	Hydrogen	62-64	cytochrome c, somatic	Homo sapiens	98-110
2154849-4	1990	As individual cytochrome c lysyl residues are resolved in the 1H NMR spectrum of N-acetimidylated cytochrome c, the interaction of this modified protein with cytochrome b5 has been studied to evaluate the number of cytochrome c lysyl residues involved in binding to cytochrome b5.	Hydrogen	62-64	cytochrome c, somatic	Homo sapiens	98-110
2163402-1	1990	Seven well-resolved signals could be observed in the field lower than 9.5 ppm in the 1H-NMR spectrum of the H2O solution of cyclic AMP receptor protein (CRP).	Hydrogen	85-87	C-reactive protein	Homo sapiens	124-151
2163402-1	1990	Seven well-resolved signals could be observed in the field lower than 9.5 ppm in the 1H-NMR spectrum of the H2O solution of cyclic AMP receptor protein (CRP).	Hydrogen	85-87	C-reactive protein	Homo sapiens	153-156
2292433-2	1990	Hydroxyl radicals abstract hydrogen atoms from glycerol-2-phosphate with a specific rate constant of (7.0 +/- 1.5) x 10(8) M-1s-1 forming the beta-phospho radical as the major product.	Hydrogen	27-35	tumor associated calcium signal transducer 2	Homo sapiens	123-129
2083145-0	1990	Calmodulin discriminates between the two enantiomers of the receptor-operated calcium channel blocker SK&amp;F 96365: a study using 1H-NMR and chiral HPLC.	Hydrogen	132-134	calmodulin 1	Homo sapiens	0-10
2083145-1	1990	1H nuclear magnetic resonance at 360 MHz shows that SK&amp;F 96365 (1-(beta-[3-(p-methoxyphenyl)-propyloxy]-p-methoxyphenethyl)-1H- imidazole hydrochloride), an antagonist of mammalian receptor-operated calcium channels, interacts with the calcium-binding regulatory protein calmodulin (CaM).	Hydrogen	0-2	calmodulin 1	Homo sapiens	275-285
2083145-1	1990	1H nuclear magnetic resonance at 360 MHz shows that SK&amp;F 96365 (1-(beta-[3-(p-methoxyphenyl)-propyloxy]-p-methoxyphenethyl)-1H- imidazole hydrochloride), an antagonist of mammalian receptor-operated calcium channels, interacts with the calcium-binding regulatory protein calmodulin (CaM).	Hydrogen	0-2	calmodulin 1	Homo sapiens	287-290
2131820-0	1990	Low kinetic hydrogen isotope effects in the dehydrogenation of 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (nifedipine) by cytochrome P-450 enzymes are consistent with an electron/proton/electron transfer mechanism.	Hydrogen	12-20	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	167-183
2131820-7	1990	These results are interpreted in terms of an electron/proton/electron transfer mechanism previously postulated for the oxidation of other dihydropyridines by cytochrome P-450 enzymes and model one-electron acceptors and argue against a mechanism involving hydrogen atom abstraction from nifedipine.	Hydrogen	256-264	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	158-174
1876050-0	1990	A computer-aided investigation into the role of hydrogen bonding in the binding conformation of the endo-ethenotetrahydrooripavine, PEO.	Hydrogen	48-56	twinkle mtDNA helicase	Homo sapiens	132-135
2167270-1	1990	Acute intoxication by CCl4 induces morphological changes in rat liver which are readily detectable by 1H-NMR imaging techniques in situ.	Hydrogen	102-104	C-C motif chemokine ligand 4	Rattus norvegicus	22-26
33774150-0	2021	Hydrogen enriched saline alleviates morphine tolerance via inhibiting neuroinflammation, GLT-1, GS nitration and NMDA receptor trafficking and functioning in the spinal cord of rats.	Hydrogen	0-8	solute carrier family 1 member 2	Rattus norvegicus	89-94
2100004-1	1990	Conformation of the renin inhibitor peptide, Pro-His-Pro-Phe-His-Phe-Phe-Val-Tyr-Lys (RIP) has been studied in aqueous solution and in lipid bilayers using 500 MHz 1H NMR spectroscopy.	Hydrogen	164-166	renin	Homo sapiens	20-25
33773191-13	2021	Molecular docking simulation further evidenced that DS-1 interacts with MDM2 within the p53-binding domain by carbon-hydrogen bond interaction at Lys27, pi-alkyl interactions at Ile37 and Leu30, and van der Waals interactions at Ile75, Val51, Val69, Phe67, Met38, Tyr43, Gly34, and Phe31.	Hydrogen	117-125	tumor protein p53	Homo sapiens	88-91
33774150-9	2021	Our result showed that hydrogen pretreatment prevented morphine tolerance by reducing neuroinflammation, GLT-1, GS nitration, NMDA receptor trafficking in the spinal dorsal horn.	Hydrogen	23-31	solute carrier family 1 member 2	Rattus norvegicus	105-110
33773206-0	2021	Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.	Hydrogen	0-8	DNA methyltransferase (cytosine-5) 1	Mus musculus	104-109
33773206-0	2021	Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.	Hydrogen	0-8	DNA methyltransferase 3A	Mus musculus	114-120
33772471-9	2021	Besides, the formation of networking between the formed AgNPs and beta-CD through hydrogen bonding prevented the agglomeration of AgNPs, ensuring their high catalytic ability.	Hydrogen	82-90	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	66-73
33822449-3	2021	The chiral information of CSA are effectively transferred to the microcrystals by hydrogen bonding to afford full-color CPL from deep-blue to red with g lum in the order of 10 -2 and Phi FL up to 80%.	Hydrogen	82-90	lumican	Homo sapiens	153-156
33764593-7	2021	The stability of most active/PARP-2 complex is confirmed by hydrogen bonding and pi-pi stacking interaction parameters.	Hydrogen	60-68	poly(ADP-ribose) polymerase 2	Homo sapiens	29-35
33767697-8	2021	Hydrogen significantly improved the survival rate of mice, reduced pulmonary edema and hemorrhage, infiltration of neutrophils, and IL-6 secretion.	Hydrogen	0-8	interleukin 6	Mus musculus	132-136
33816577-11	2021	Structural modeling of the AAT-RC-2/FXIa encounter complex suggested that both E (Glu) substitutions at P3 and P3" may promote FXIa binding via hydrogen bonding to K192 in FXIa.	Hydrogen	144-152	serpin family A member 1	Homo sapiens	27-30
33809196-0	2021	Biflavonoid-Induced Disruption of Hydrogen Bonds Leads to Amyloid-beta Disaggregation.	Hydrogen	34-42	amyloid beta precursor protein	Homo sapiens	58-70
33809196-9	2021	Hydrogen bond analysis further supported that the substitution of hydroxyl groups capable of hydrogen bond formation at two positions on the biflavonoid scaffold leads to significantly disaggregation of Abeta fibrils.	Hydrogen	0-8	amyloid beta precursor protein	Homo sapiens	203-208
33809196-9	2021	Hydrogen bond analysis further supported that the substitution of hydroxyl groups capable of hydrogen bond formation at two positions on the biflavonoid scaffold leads to significantly disaggregation of Abeta fibrils.	Hydrogen	93-101	amyloid beta precursor protein	Homo sapiens	203-208
33804289-2	2021	These effects arise from the inhibition of two distinct cancer targets: the trypsin-like serine protease urokinase-type plasminogen activator (uPA), a cell-surface mediator of matrix degradation and tumor cell invasiveness, and the sodium-hydrogen exchanger isoform-1 (NHE1), a central regulator of transmembrane pH that supports carcinogenic progression.	Hydrogen	239-247	plasminogen activator, urokinase	Homo sapiens	143-146
33799840-0	2021	Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents.	Hydrogen	0-8	interleukin 6	Homo sapiens	72-85
33767697-9	2021	Inhalation of hydrogen decreased tissue factor (TF) expression and MMP-9 activity, while Trx1 expression was increased in the lungs and serum of endotoxemia mice.	Hydrogen	14-22	coagulation factor III	Mus musculus	33-46
33767697-9	2021	Inhalation of hydrogen decreased tissue factor (TF) expression and MMP-9 activity, while Trx1 expression was increased in the lungs and serum of endotoxemia mice.	Hydrogen	14-22	coagulation factor III	Mus musculus	48-50
32795534-0	2020	Disruption of Hydrogen-Bond Network in Rhodopsin Mutations Cause Night Blindness.	Hydrogen	14-22	rhodopsin	Homo sapiens	39-48
33803465-0	2021	Regulation of K+ Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels.	Hydrogen	34-42	potassium voltage-gated channel subfamily A member 2	Homo sapiens	69-74
33350827-7	2021	Hydrogen/deuterium exchange mass spectrometry demonstrates that cholesterol in the membrane induces asymmetric, long-range changes in the distributions and exchange kinetics of conformations of the nucleotide-binding domains, correlating the effects of lipid composition on activity with specific changes in the P-gp conformational landscape.	Hydrogen	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	312-316
28395511-7	2017	We find that C6D6-derived products recovered from P &lt; 35 GPa actively react with moisture, forming polymers with higher sp3 hydrogen contents.	Hydrogen	127-135	Sp3 transcription factor	Homo sapiens	123-126
28894978-0	2018	Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-beta in Guinea Pigs.	Hydrogen	0-8	forkhead box protein P3	Cavia porcellus	119-124
28894978-3	2018	We herein aim to verify the protective effects of hydrogen on CD4+CD25+Foxp3+Treg cells in guinea pigs with AR and to explore the effect of hydrogen-rich saline (HRS) on CD4+CD25+Foxp3+Treg cells in animals with AR and investigate the underlying anti-inflammatory mechanism.	Hydrogen	50-58	forkhead box protein P3	Cavia porcellus	71-76
17973474-3	2007	Structural and spectroscopic studies show that there are four hydrogen-bond (H-bond) donors near the CoII-micro-OH-CoII moiety; however, they are too far away to be form intramolecular H-bonds with the bridging hydroxo ligand.	Hydrogen	62-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-105
26429211-6	2015	The best catalytic performance was obtained for the Co(III) corrole, whose onset potential was as positive as 0.81 V versus the reversible hydrogen electrode (RHE).	Hydrogen	139-147	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	52-59
25527812-11	2015	CONCLUSIONS: The between-person variation of hs-cTnT in the dialysis population is markedly greater than within-person variation indicating that hs-cTnT testing is best applied in this population using a relative change strategy.	Hydrogen	45-47	troponin T2, cardiac type	Homo sapiens	48-52
19138732-3	2009	In the copolymers permeability of B12 is controlled by both intramolecular and intermolecular hydrogen-bonding between the pyrrolidinone and carboxylic acid side chains.	Hydrogen	94-102	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	34-37
19914718-4	2010	NF-kappaB p65 and TNF-alpha were elevated at both 10 min and 1h post exposure.	Hydrogen	61-63	tumor necrosis factor	Homo sapiens	18-27
17973474-3	2007	Structural and spectroscopic studies show that there are four hydrogen-bond (H-bond) donors near the CoII-micro-OH-CoII moiety; however, they are too far away to be form intramolecular H-bonds with the bridging hydroxo ligand.	Hydrogen	62-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-119
34309842-9	2022	The molecular docking results showed that two peptides could bind angiotensin-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) tightly by hydrogen bonding and hydrophobic interaction.	Hydrogen	150-158	angiotensin I converting enzyme	Homo sapiens	66-95
34802756-4	2022	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).	Hydrogen	104-112	chromogranin A	Homo sapiens	275-278
34715300-6	2022	MATERIALS AND METHODS: The main compounds in CBP extract were analyzed by UPLC, 1H-NMR and 13C-NMR spectroscopic techniques.	Hydrogen	80-82	CREB binding protein	Homo sapiens	45-48
34959176-5	2022	According to this data, it is possible to infer that extra hydrophobic interactions and the hydrogen interactions with the triazole core may improve the selectivity towards the COX-2 active site.	Hydrogen	92-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
12147223-4	2002	CML-BSA also stimulated DNA-binding activity of activator protein-1 (AP-1) within 3h, but the stimulatory effect decreased in 5h, and nuclear factor-kappaB (NF-kappaB) with a peak activity at 1h and the stimulatory effect diminished in 3h.	Hydrogen	192-194	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-155
12147223-4	2002	CML-BSA also stimulated DNA-binding activity of activator protein-1 (AP-1) within 3h, but the stimulatory effect decreased in 5h, and nuclear factor-kappaB (NF-kappaB) with a peak activity at 1h and the stimulatory effect diminished in 3h.	Hydrogen	192-194	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
8510409-5	1993	While in control cells the cell-associated heparan sulfate accounts for about 30% of the total glycosaminoglycans under the influence of bFGF the HS percentage increases to approximately 60%.	Hydrogen	146-148	fibroblast growth factor 2	Bos taurus	137-141
34973200-5	2022	The functional group from the three-dimensional skeleton structures of ALP-p for BPA anchoring endowed chemisorption via pi-pi interaction between benzene rings and hydrogen-bonding (O-H O, C-H N, C-H O and C-H C) with the hydrogen atom of benzene ring, -OH from BPA and -OH, NN from ALP-p, respectively.	Hydrogen	165-173	alkaline phosphatase, placental	Homo sapiens	71-74
34973200-5	2022	The functional group from the three-dimensional skeleton structures of ALP-p for BPA anchoring endowed chemisorption via pi-pi interaction between benzene rings and hydrogen-bonding (O-H O, C-H N, C-H O and C-H C) with the hydrogen atom of benzene ring, -OH from BPA and -OH, NN from ALP-p, respectively.	Hydrogen	165-173	alkaline phosphatase, placental	Homo sapiens	284-287
34973200-5	2022	The functional group from the three-dimensional skeleton structures of ALP-p for BPA anchoring endowed chemisorption via pi-pi interaction between benzene rings and hydrogen-bonding (O-H O, C-H N, C-H O and C-H C) with the hydrogen atom of benzene ring, -OH from BPA and -OH, NN from ALP-p, respectively.	Hydrogen	223-231	alkaline phosphatase, placental	Homo sapiens	71-74
34954480-4	2022	The analysis results of thermodynamic parameters confirmed that the dominate interaction forces were the hydrophobic and hydrogen-bonding interactions for stabilizing the estradiol-beta-CD complex, and were the hydrogen bonding interaction and van der Waals forces for stabilizing the estradiol-HP-beta-CD complex.	Hydrogen	121-129	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	181-188
34954480-4	2022	The analysis results of thermodynamic parameters confirmed that the dominate interaction forces were the hydrophobic and hydrogen-bonding interactions for stabilizing the estradiol-beta-CD complex, and were the hydrogen bonding interaction and van der Waals forces for stabilizing the estradiol-HP-beta-CD complex.	Hydrogen	211-219	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	298-305
34802756-7	2022	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-pi, pi-pi, cation-pi interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.	Hydrogen	144-152	chromogranin A	Homo sapiens	256-259
34802756-7	2022	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-pi, pi-pi, cation-pi interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.	Hydrogen	166-174	chromogranin A	Homo sapiens	256-259
34952091-5	2022	According to our computations, compared with raw BC2NNTs, the role of hydrogen bonds between 3-ASH molecules" active sites and carboxyl-functionalized BC2NNTs in the complexes" fixation, adsorption, and thermodynamic energy is of great importance.	Hydrogen	70-78	arylsulfatase family member H	Homo sapiens	95-98
34970349-12	2022	In addition the protein expression levels of RIP1 and RIP3 and the cytokines NF-kappaB, TNF-alpha, IL-1beta and IL-6 were downregulated compared with the TBI group, which demonstrated that hydrogen-rich saline-induced inhibition of necroptosis and neuroinflammation ameliorated neuronal death following TBI.	Hydrogen	189-197	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	45-49
34970349-12	2022	In addition the protein expression levels of RIP1 and RIP3 and the cytokines NF-kappaB, TNF-alpha, IL-1beta and IL-6 were downregulated compared with the TBI group, which demonstrated that hydrogen-rich saline-induced inhibition of necroptosis and neuroinflammation ameliorated neuronal death following TBI.	Hydrogen	189-197	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	77-86
34970349-12	2022	In addition the protein expression levels of RIP1 and RIP3 and the cytokines NF-kappaB, TNF-alpha, IL-1beta and IL-6 were downregulated compared with the TBI group, which demonstrated that hydrogen-rich saline-induced inhibition of necroptosis and neuroinflammation ameliorated neuronal death following TBI.	Hydrogen	189-197	tumor necrosis factor	Mus musculus	88-97
34970349-12	2022	In addition the protein expression levels of RIP1 and RIP3 and the cytokines NF-kappaB, TNF-alpha, IL-1beta and IL-6 were downregulated compared with the TBI group, which demonstrated that hydrogen-rich saline-induced inhibition of necroptosis and neuroinflammation ameliorated neuronal death following TBI.	Hydrogen	189-197	interleukin 6	Mus musculus	112-116
34970349-13	2022	The neuroprotective capacity of hydrogen-rich saline was demonstrated to be partly dependent on the ROS/heme oxygenase-1 signaling pathway.	Hydrogen	32-40	heme oxygenase 1	Mus musculus	104-120
34309842-9	2022	The molecular docking results showed that two peptides could bind angiotensin-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) tightly by hydrogen bonding and hydrophobic interaction.	Hydrogen	150-158	angiotensin I converting enzyme	Homo sapiens	97-100
34896364-4	2022	Using hydrogen-deuterium exchange with mass spectrometry (HDX), CD4 peptides showed differential rates of deuteration (either enhanced or slowed) in the presence of the adnectin that mapped predominantly to the interface of domains 2 and 3 (D2-D3).	Hydrogen	6-14	CD4 molecule	Homo sapiens	64-67
34757082-5	2022	sirt1 contributed to the repair of LPS-induced ALI by hydrogen through the regulation of NF-kappaB and catalase expression.	Hydrogen	54-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	89-98
34757082-5	2022	sirt1 contributed to the repair of LPS-induced ALI by hydrogen through the regulation of NF-kappaB and catalase expression.	Hydrogen	54-62	catalase	Mus musculus	103-111
34757082-6	2022	In conclusion, 66.7 % hydrogen protected against LPS-induced ALI by suppressing inflammatory response and oxidative stress mediated by NF-kappaB and catalase in a sirt1-dependent manner.	Hydrogen	22-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
34757082-6	2022	In conclusion, 66.7 % hydrogen protected against LPS-induced ALI by suppressing inflammatory response and oxidative stress mediated by NF-kappaB and catalase in a sirt1-dependent manner.	Hydrogen	22-30	catalase	Mus musculus	149-157
34536893-3	2022	Through the analysis of a series of structural parameters related to hydrogen bonding interactions, it could be found that the hydrogen bonds of the three derivatives are all enhanced in the S1 state, and more importantly, the excited-state hydrogen bonds of HOF are stronger than those of SHOF and NSHOF.	Hydrogen	69-77	zinc finger and BTB domain containing 20	Homo sapiens	259-262
34536893-3	2022	Through the analysis of a series of structural parameters related to hydrogen bonding interactions, it could be found that the hydrogen bonds of the three derivatives are all enhanced in the S1 state, and more importantly, the excited-state hydrogen bonds of HOF are stronger than those of SHOF and NSHOF.	Hydrogen	127-135	zinc finger and BTB domain containing 20	Homo sapiens	259-262
34536893-3	2022	Through the analysis of a series of structural parameters related to hydrogen bonding interactions, it could be found that the hydrogen bonds of the three derivatives are all enhanced in the S1 state, and more importantly, the excited-state hydrogen bonds of HOF are stronger than those of SHOF and NSHOF.	Hydrogen	241-249	zinc finger and BTB domain containing 20	Homo sapiens	259-262
34536893-5	2022	We find that for HOF, SHOF, and NSHOF, the strength of the excited-state hydrogen bonds increases as the solvent polarity decreases.	Hydrogen	73-81	zinc finger and BTB domain containing 20	Homo sapiens	17-20
34919400-4	2022	We show that the inhibitor induces an increase of the enzyme radius of gyration due to the expansion on one of the dimer interfaces; the structural changes observed, including the active site pocket volume increase and the decrease in the monomer-monomer buried surface area and of the number of hydrogen bonds (as compared to the inactive enzyme control simulation), indicate that the catalytically competent (open) conformation of hTK1 can be assumed in the presence of an activating ligand.	Hydrogen	296-304	thymidine kinase 1	Homo sapiens	433-437
34793155-5	2022	Furthermore, using room-temperature X-ray crystallography, we show that MCULE-5948770040 binds to a cleft in the primary binding site of Mpro forming stable hydrogen bond and hydrophobic interactions.	Hydrogen	157-165	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	137-141
34388430-11	2022	Meanwhile, the fluorescence intensity of PIM declines with the decrease of pH because the Schiff base of PIM is hydrolyzed, which was affirmed by 1H NMR, LC-MS and fluorescence spectra.	Hydrogen	146-148	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	41-44
34388430-11	2022	Meanwhile, the fluorescence intensity of PIM declines with the decrease of pH because the Schiff base of PIM is hydrolyzed, which was affirmed by 1H NMR, LC-MS and fluorescence spectra.	Hydrogen	146-148	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	105-108
34716642-1	2022	A photoinitiated anti -hydropentafluorosulfanylation of terminal alkynes using SF 5 Cl and (TMS) 3 SiH as the hydrogen atom donor is reported.	Hydrogen	110-118	PYD and CARD domain containing	Homo sapiens	92-95
34914357-1	2022	Electrocatalytic nitrate (NO3-) reduction to N2 via atomic hydrogen (H*) is a promising approach for advanced water treatment.	Hydrogen	59-67	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
34602005-9	2022	The results of FTIR and 1H NMR spectra confirmed the successful synthesis of poly(AAc-co-SA-AC-co-allyl-beta-CD).	Hydrogen	24-26	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	104-111
34655499-4	2022	Here, we report a pH-responsive metal-organic framework hydrogen generation nanoparticle (Pd(H)@ZIF-8), which is encapsulated with ascorbate palmitate (AP) hydrogel.	Hydrogen	56-64	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	90-101
34655499-6	2022	The released Pd(H)@ZIF-8 nanoparticles are further decomposed by gastric acid to generate zinc ions (Zn2+ ) and hydrogen, thus effectively killing H. pylori, alleviating inflammation and restoring impaired gastric mucosa simultaneously.	Hydrogen	112-120	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	13-24
34655499-7	2022	Unexpectedly, this metal-organic framework hydrogen generation platform (Pd(H)@ZIF-8@AP) also has an inappreciable impact toward intestinal flora, which thus provides a more precise, effective and healthy strategy for the treatment of H. pylori infection.	Hydrogen	43-51	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	73-84
34523465-7	2022	The mechanisms of Pb(II) removal from aqueous solutions involved electrostatic attraction, hydrogen bonding, physical adsorption, ion exchange and oxidoreduction.	Hydrogen	91-99	submaxillary gland androgen regulated protein 3B	Homo sapiens	18-24
34976136-0	2022	NLRP3 inflammasome activation in gestational diabetes mellitus placentas is associated with hydrogen sulfide synthetase deficiency.	Hydrogen	92-100	NLR family pyrin domain containing 3	Homo sapiens	0-5
34896463-3	2022	FTIR spectra demonstrated that the interactions between starches or starch and CAT/beta-CD were enhanced by hydrogen bonds.	Hydrogen	108-116	chloramphenicol acetyltransferase	Staphylococcus aureus	79-82
34762267-8	2022	are active against the three virulent factors such as cag-A, vac-A, and Htr-A with multiple hydrogen, vdW, electrostatic interactions, and mild pi-hydrophobic bindings with the libdock energy score for CagA, VacA and HtrA are 175.625, 158.603 and 89.397 kcal/mol.	Hydrogen	92-100	telomerase RNA component	Homo sapiens	72-75
34966948-7	2021	Furthermore, after phosphorylating the C-terminal tail and intracellular loop 3 (ICL3) of NF-alpha1/CPE-5-HTR1E, it recruited beta-arrestin1 by forming numerous salt bridges and hydrogen bonds to ICL2 and ICL3, leading to activation of beta-arrestin1.	Hydrogen	178-186	5-hydroxytryptamine receptor 1E	Homo sapiens	106-111
34979448-5	2021	Molecular docking experiments indicated that A1 formed a hydrogen bond between the 12-OH and amino acid Thr131 of TGR5, which is significant for its allosteric property.	Hydrogen	57-65	G protein-coupled bile acid receptor 1	Homo sapiens	114-118
34302583-0	2022	Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques.	Hydrogen	89-97	profilin 1	Homo sapiens	73-83
34825490-0	2022	Engineering In-Plane Nickel Phosphide Heterointerfaces with Interfacial sp H P Hybridization for Highly Efficient and Durable Hydrogen Evolution at 2 A cm-2.	Hydrogen	126-134	surfactant associated 3	Homo sapiens	72-76
34966948-7	2021	Furthermore, after phosphorylating the C-terminal tail and intracellular loop 3 (ICL3) of NF-alpha1/CPE-5-HTR1E, it recruited beta-arrestin1 by forming numerous salt bridges and hydrogen bonds to ICL2 and ICL3, leading to activation of beta-arrestin1.	Hydrogen	178-186	arrestin beta 1	Homo sapiens	126-140
34966948-7	2021	Furthermore, after phosphorylating the C-terminal tail and intracellular loop 3 (ICL3) of NF-alpha1/CPE-5-HTR1E, it recruited beta-arrestin1 by forming numerous salt bridges and hydrogen bonds to ICL2 and ICL3, leading to activation of beta-arrestin1.	Hydrogen	178-186	arrestin beta 1	Homo sapiens	236-250
34883021-3	2021	The dual cross-linked network of the PSNC hydrogel combined the double hydrogen bonding of N-(2-amino-2-oxyethyl)acrylamide (NAGA) with a covalently cross-linked zwitterionic network, endowing the hydrogel with skin-like mechanical properties with a high stretchability of 1613.8 +- 79.8%, a tensile strength of 77.5 +- 1.8 kPa, and a tensile modulus of 1.9 +- 0.1 kPa.	Hydrogen	71-79	alpha-N-acetylgalactosaminidase	Homo sapiens	125-129
34939532-5	2021	The 33 amino acid residues of cocoonase shows interaction with 38 aa residues of sericin involving 4 disulphide bonds, 22 hydrogen bonds and 319 non-bonded contacts.	Hydrogen	122-130	cocoonase	Bombyx mori	30-39
34904615-0	2021	1D alignment of Co(II) metalated porphyrin-napthalimide based self-assembled nanowires for photocatalytic hydrogen evolution.	Hydrogen	106-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-22
34936214-5	2022	Molecular modeling study indicated that compound 5 formed hydrogen bond network with key residues of FXR.	Hydrogen	58-66	nuclear receptor subfamily 1, group H, member 4	Mus musculus	101-104
34904615-5	2021	Detailed studies suggest that the Co(II) substituent D-A system (PN2) displayed a well-aligned one-dimensional (1D) nanowire with high electrical conductivity promoting remarkable photocatalytic hydrogen production rate (18 mM g-1 h-1) when compared to that of porphyrin-based derivatives reported until now.	Hydrogen	195-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
34904615-5	2021	Detailed studies suggest that the Co(II) substituent D-A system (PN2) displayed a well-aligned one-dimensional (1D) nanowire with high electrical conductivity promoting remarkable photocatalytic hydrogen production rate (18 mM g-1 h-1) when compared to that of porphyrin-based derivatives reported until now.	Hydrogen	195-203	amyloid beta precursor protein	Homo sapiens	65-68
34953939-0	2022	Hydrogen attenuated inflammation response and oxidative in hypoxic ischemic encephalopathy via Nrf2 mediated the inhibition of NLRP3 and NF-kappaB.	Hydrogen	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
34953939-0	2022	Hydrogen attenuated inflammation response and oxidative in hypoxic ischemic encephalopathy via Nrf2 mediated the inhibition of NLRP3 and NF-kappaB.	Hydrogen	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	137-146
34953939-6	2022	Herein, the research focuses on the mechanisms by which Nrf2 participates in the protection of hydrogen against HIE.	Hydrogen	95-103	nuclear factor, erythroid derived 2, like 2	Mus musculus	56-60
34953939-8	2022	First, Nrf2 pathway activity was detected after hypoxia-ischaemia (HI) followed or not by hydrogen treatment.	Hydrogen	90-98	nuclear factor, erythroid derived 2, like 2	Mus musculus	7-11
34874023-2	2021	The hydrogen evolution rate of CTF-7 is 7430 mumol g-1 h-1, which is about 5.6 times that of CTF-8.	Hydrogen	4-12	chromosome transmission fidelity factor 8	Homo sapiens	93-98
34882410-0	2021	Hydrogen-Rich 2D Halide Perovskite Scintillators for Fast Neutron Radiography.	Hydrogen	0-8	Fas activated serine/threonine kinase	Homo sapiens	53-57
34882410-4	2021	Here, we demonstrate a hydrogen-rich long-chain organic amine modified two-dimensional (2D) perovskite fast neutron scintillator, Mn-(C18H37NH3)2PbBr4(Mn-STA2PbBr4).	Hydrogen	23-31	Fas activated serine/threonine kinase	Homo sapiens	103-107
34882410-5	2021	Its hydrogen density can reach 9.51 x 1028 m-3, and the photoluminescence quantum yield can reach 58.58%, so it is possible to integrate fast neutron absorption and luminescence into a single compound.	Hydrogen	4-12	Fas activated serine/threonine kinase	Homo sapiens	137-141
34902253-0	2021	Photochemical Deracemization at sp3-Hybridized Carbon Centers via a Reversible Hydrogen Atom Transfer.	Hydrogen	79-87	Sp3 transcription factor	Homo sapiens	32-35
34921410-8	2021	Compared with benzoic acid, 2,4-dihydroxycinnamic acid was easier to form more hydrogen bonds in the active site of PPO, making the interaction more stable.	Hydrogen	79-87	protoporphyrinogen oxidase	Homo sapiens	116-119
34953939-13	2022	In addition, the absence of Nrf2 abolished the suppressive effect of hydrogen on the expression of Nacht, Lrr, and Pyd domains-containing protein 3 (NLRP3) pathway members and p65 NF-kappaB after HI.	Hydrogen	69-77	nuclear factor, erythroid derived 2, like 2	Mus musculus	28-32
34953939-14	2022	Taken together, our findings showed that hydrogen alleviated cellular injury and apoptosis, neurobehavioural deficits, the inflammatory response and oxidative stress via the Nrf2-mediated NLRP3 and NF-kappaB pathways.	Hydrogen	41-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	174-178
34953939-14	2022	Taken together, our findings showed that hydrogen alleviated cellular injury and apoptosis, neurobehavioural deficits, the inflammatory response and oxidative stress via the Nrf2-mediated NLRP3 and NF-kappaB pathways.	Hydrogen	41-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	198-207
34907850-12	2021	Amentoflavone has the ability to inhibit acetylcholinesterase when tested in vitro, having an IC50 of 8.68 +- 0.73 microg/mL, corroborating its effect in the in silico test, presenting four strong covalent hydrogen bonds for having a bond length up to 2.5 A.	Hydrogen	206-214	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-61
34808043-7	2021	The obtained thermodynamic parameters reveal interactions driven by van der Waals forces and hydrogen bonds in the lapatinib-AChE system (DeltaH  and DeltaS  < 0).	Hydrogen	93-101	acetylcholinesterase (Cartwright blood group)	Homo sapiens	125-129
34325175-4	2021	The molecular docking and isothermal titration calorimetry (ITC) results showed that sodium benzoate entered the depression of the surface of lysozyme molecule both through hydrophobic interaction and hydrogen bond.	Hydrogen	201-209	lysozyme	Homo sapiens	142-150
34946702-3	2021	Structural and energetic computation results revealed that hydrogen bonds and van der Waals interactions played significant roles in the stabilization of the formed Dex@beta-CD complex.	Hydrogen	59-67	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	169-176
34948107-0	2021	Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model.	Hydrogen	23-31	gastrin	Mus musculus	32-35
34993488-4	2021	Doping of 7 wt% NP-TiH2@G enables a full dehydrogenation of NaAlH4 at 80 C and rehydrogenation at 30 C under 100 atm H2 with a reversible hydrogen capacity of 5 wt%, superior to all literature results reported so far.	Hydrogen	138-146	RuvB like AAA ATPase 2	Homo sapiens	19-23
34993488-5	2021	This indicates that nanostructured TiH2 is much more effective than Ti-dopants in improving the hydrogen storage performance of NaAlH4.	Hydrogen	96-104	RuvB like AAA ATPase 2	Homo sapiens	35-39
34274637-2	2021	Out of seventeen possible isomers of this molecule located on the singlet potential energy surface the most stable one, APA1 comprising intramolecular O-H   N and N-H   O hydrogen bonds, was detected experimentally in the matrix after deposition.	Hydrogen	171-179	zinc finger protein 410	Homo sapiens	120-124
34907481-5	2021	In addition, the high-affinity PDE9A inhibitors always interact with the conservative hydrophobic pocket as well as Tyr424 and Ala452 of PDE9A, while PDE10A selective inhibitors need to have two hydrophobic groups and two hydrogen bond donors to interact with the conservative Tyr693, Gln726, and Phe729 of PDE10A.	Hydrogen	222-230	phosphodiesterase 10A	Homo sapiens	150-156
34907481-5	2021	In addition, the high-affinity PDE9A inhibitors always interact with the conservative hydrophobic pocket as well as Tyr424 and Ala452 of PDE9A, while PDE10A selective inhibitors need to have two hydrophobic groups and two hydrogen bond donors to interact with the conservative Tyr693, Gln726, and Phe729 of PDE10A.	Hydrogen	222-230	phosphodiesterase 10A	Homo sapiens	307-313
34955862-9	2021	Treatment of curcumin alleviated the compensatory activation of the Nrf2 pathway induced by oxidative stress, by virtue of its antioxidant ability to transfer hydrogen atoms to free radicals.	Hydrogen	159-167	NFE2 like bZIP transcription factor 2	Rattus norvegicus	68-72
34948107-2	2021	In the present study, we investigated the effects of hydrogen (H2) gas inhalation in trimethyltin (TMT)-induced neurotoxicity and cognitive dysfunction in the C57BL/6 mice.	Hydrogen	53-61	gastrin	Mus musculus	67-70
34870594-6	2021	Here we identify a hydrogen bond between the side chain of arginine 117 and the backbone carbonyl group of glutamate 1124 in the cryo-electronmicroscopic structure of phosphorylated, ATP-bound CFTR.	Hydrogen	19-27	CF transmembrane conductance regulator	Homo sapiens	193-197
34705466-6	2021	In vitro enzyme inhibition assays and room-temperature X-ray structures demonstrated the effect of chemical modifications on Mpro inhibition, showing that (1) maintaining correct geometry of an inhibitor"s P1 group is essential to preserve the hydrogen bond with the protonated His163; (2) a positively charged linker is preferred; and (3) subsite S2 prefers nonbulky modestly electronegative groups.	Hydrogen	244-252	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	125-129
34809430-0	2021	Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers.	Hydrogen	148-156	androgen receptor	Homo sapiens	21-38
34809430-6	2021	Furthermore, 92 inhibited the formation of the AR LBD dimer, possibly through attenuating the hydrogen-bonding network between the two monomers.	Hydrogen	94-102	androgen receptor	Homo sapiens	47-49
34943069-5	2021	Large kinetic isotope effects (KIE, kH/kD) were observed for the hydrogen-transfer reaction from Trolox to the beta-CD-solubilized DPPH  in the whole temperature range.	Hydrogen	65-73	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	111-118
34846390-3	2021	UV/Vis absorption data of ThTCF show subtle correlations with hydrogen bond accepting (HBA) ability-related measurands such as Kamlet-Taft beta, Freire"s EHB, and Laurence beta1 parameter as a function of anion and cation structure.	Hydrogen	62-70	BCL2 related protein A1	Homo sapiens	172-177
34839662-3	2021	Herein, beta-cyclodextrin (beta-CD) is first demonstrated as a multifunctional filler that can form a continuous hydrogen bond network with the ether oxygen unit from the PEO matrix, thus improving the comprehensive performances of the PEO-based CSE.	Hydrogen	113-121	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	27-34
34839662-4	2021	By relevant characterizations, it is demonstrated that beta-CD is uniformly dispersed into the PEO substrate, inducing adequate dissociation of lithium salt and enhancing mechanical strength through hydrogen bond interactions.	Hydrogen	199-207	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	55-62
34865653-7	2021	Additionally, dieckol exhibited a high affinity with SARS-CoV-2 Mpro using surface plasmon resonance (SPR) analysis and could bind to the catalytic sites of Mpro through hydrogen-bond interactions in the predicted docking model.	Hydrogen	170-178	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	64-68
34865653-7	2021	Additionally, dieckol exhibited a high affinity with SARS-CoV-2 Mpro using surface plasmon resonance (SPR) analysis and could bind to the catalytic sites of Mpro through hydrogen-bond interactions in the predicted docking model.	Hydrogen	170-178	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	157-161
34926886-6	2021	The computational results suggest that the chemical nature of inhibitors affects the binding mode and their association with PSMA is primarily dominated by hydrogen bonding, salt bridge, electrostatic, and pi-pi interactions.	Hydrogen	156-164	folate hydrolase 1	Homo sapiens	125-129
34884849-8	2021	HIF1 binding in the HRE containing -964G allele results in more hydrogen bonds and van der Waals contact formation than HRE with -964A allele.	Hydrogen	64-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-4
34885967-7	2021	Pharmacophore model analysis further revealed that the aromatic ring, hydrogen bond donor, and hydrophobic group are the essential infrastructure of Mpro inhibitors.	Hydrogen	70-78	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	149-153
34634688-3	2021	This current research aims to observe the therapeutic effect of high concentration hydrogen (67%, HCH) on lipopolysaccharide (LPS) induced acute lung injury (ALI), and further investgate the role of Nrf2 signaling pathway.	Hydrogen	83-91	nuclear factor, erythroid derived 2, like 2	Mus musculus	199-203
34943036-0	2021	A Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl4-Induced Chronic Liver Injury in Rats.	Hydrogen	37-45	C-C motif chemokine ligand 4	Rattus norvegicus	71-75
34943036-3	2021	The purpose of this study was to investigate the effect of hydrogen gas (3%) on early chronic liver injury (CLI) induced by CCl4 and to preliminarily explore the protective mechanism of hydrogen gas on hepatocytes by observing the expression of uncoupling protein 2 (UCP2) in liver tissue.	Hydrogen	59-67	C-C motif chemokine ligand 4	Rattus norvegicus	124-128
34656558-5	2021	The thermodynamics results from ITC revealed DCF-HSA interaction was exothermic and spontaneous and involved hydrophobic interactions and hydrogen bonding.	Hydrogen	138-146	albumin	Homo sapiens	49-52
34710811-8	2021	Furthermore, the hydrogen bond acceptor/donator ratio was approximately 4:1 in Cpd38-BRD4 system compared with 2:1 in Cpd38-EP300 system.	Hydrogen	17-25	bromodomain containing 4	Homo sapiens	85-89
34926555-2	2021	The surface hydrophobicity of the BPC/SPI complex driven by hydrogen bonds and electrostatic attractions was improved.	Hydrogen	60-68	chromogranin A	Homo sapiens	38-41
34634688-0	2021	High concentration of hydrogen gas alleviates Lipopolysaccharide-induced lung injury via activating Nrf2 signaling pathway in mice.	Hydrogen	22-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	100-104
34619494-9	2021	In silico docking simulation revealed that SHQA established specific interactions with the key amino acid residues of PI3K, Akt, and Nrf2-Keap1 via hydrogen bonding and van der Waals interactions, which may affect the biological capacities of target markers.	Hydrogen	148-156	AKT serine/threonine kinase 1	Rattus norvegicus	124-127
34619494-9	2021	In silico docking simulation revealed that SHQA established specific interactions with the key amino acid residues of PI3K, Akt, and Nrf2-Keap1 via hydrogen bonding and van der Waals interactions, which may affect the biological capacities of target markers.	Hydrogen	148-156	NFE2 like bZIP transcription factor 2	Rattus norvegicus	133-137
34643743-3	2021	The conformations of the different Abeta species are stabilized by intra- and inter-molecular hydrogen bonds and by electrostatic and hydrophobic interactions, all depending on the chemical and physical environment (e.g., solvent, ions, pH) and interactions with other molecules, such as lipids and proteins.	Hydrogen	94-102	amyloid beta precursor protein	Homo sapiens	35-40
34773716-10	2021	Finally, miconazole and niacin were predicted as potential therapeutic drugs for gastric adenocarcinoma that bond stably with NOS3 and NNMT through hydrogen interactions.	Hydrogen	148-156	nitric oxide synthase 3	Homo sapiens	126-130
33557647-4	2021	Molecular docking study showed that 23 binds to the active site of AChE and interacts via extensive pi-pi stacking with the indole and phenol side chains of Trp86 and Tyr337, besides the hydrogen bonding with the hydration site and pi-pi interaction with the phenol side chain of Y72.	Hydrogen	187-195	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-71
34747965-4	2021	Molecular docking and molecular dynamics simulation suggested that berberine bound stably to the active site of GR via hydrogen bonding and hydrophobic interactions.	Hydrogen	119-127	nuclear receptor subfamily 3 group C member 1	Homo sapiens	112-114
34247034-4	2021	Homologous modeling and molecular docking results indicated that the key amino acids of KA/2A9/3 scFv are TYR-92 (CDRL3), SER-93 (CDRL3), ASP-155 (CDRH1) and GLY-226 (CDRH3), and the hydrogen bond is the main force.	Hydrogen	183-191	immunglobulin heavy chain variable region	Homo sapiens	97-101
34845959-6	2021	Instead of significant hydrogen bondings with amino acid residue Ans140 as reported in previous research, the molecular docking modelling suggested a novel docking pose that involves the amino acid residues (Trp81, Pro82, Val87, Leu92, Leu94, Cys136, Asp144, and Ile146) at the active site of BRD4.	Hydrogen	23-31	bromodomain containing 4	Homo sapiens	293-297
34624571-5	2021	The different hydrophobic interactions among helices alpha1, alpha2, and alpha3 between these two states might correlate with efficient Z-DNA binding achieved by the hydrogen bonding interactions between its side-chains and the phosphate backbone of Z-DNA.	Hydrogen	166-174	BCL2 related protein A1	Homo sapiens	53-67
34783331-6	2021	Molecular docking analysis indicated that WGAP formed stable hydrogen bonds with ACE residues His353, Ala354 and ALA356.	Hydrogen	61-69	angiotensin I converting enzyme	Rattus norvegicus	81-84
34787160-11	2021	The guanidinium groups of the drugs have powerful interactions with adjacent residues due to the formation of more hydrogen bonds, suggesting that this may be the critical site for drug design against TMPRSS2.	Hydrogen	115-123	transmembrane serine protease 2	Homo sapiens	201-208
34822072-6	2022	Molecular docking results also showed that ( -)-gallocatechin gallate, ( +)-gallocatechin and baicalein can non-covalently bind to Mpro through pi-pi stacking and hydrogen bonds in the Cys145 catalytic site.	Hydrogen	163-171	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	131-135
34761900-2	2021	Herein, an innovative single electron transfer (SET) model has been expanded by using the nonadiabatic crossing integrated with the rate-determining step of 1,5-hydrogen atom transfer (HAT) reaction to provide the control mechanism of radical decay dynamics through calculating excited-state relaxation paths of a paradigm example of the amide-directed distal sp3 C-H bond alkylation mediated by Ir-complex-based photocatalysts.	Hydrogen	161-169	Sp3 transcription factor	Homo sapiens	360-363
34884494-5	2021	The mechanism by which these drugs exert their cardioprotective effects is unknown, although recent studies have shown that cardiovascular homeostasis occurs through the interplay of the sodium-hydrogen exchangers (NHE), specifically NHE1 and NHE3, with SGLT2i.	Hydrogen	194-202	solute carrier family 9 member A1	Homo sapiens	234-238
34159782-0	2021	Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin.	Hydrogen	0-8	coagulation factor II, thrombin	Homo sapiens	128-143
34159782-0	2021	Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin.	Hydrogen	0-8	coagulation factor II, thrombin	Homo sapiens	144-152
34670076-5	2021	Molecular dynamics simulations of a visual rhodopsin indicate that the conserved hydrogen-bond network from static structure can recruit dynamic hydrogen bonds and extend throughout most of the receptor.	Hydrogen	81-89	rhodopsin	Homo sapiens	43-52
34662824-2	2021	Different derivatives of beta-cyclodextrin (beta-CD) were employed as hydrogen bond acceptors (HBA) in SUPRADESs and the extraction performance investigated.	Hydrogen	70-78	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	44-51
34762436-4	2021	By changing of the sequence length, the assembly morphology changes from flat ribbon to left-handed twisted ribbon, implying a relationship between beta-sheet twist and strength of interstrand hydrogen bonds.	Hydrogen	193-201	twist family bHLH transcription factor 1	Homo sapiens	159-164
34670076-5	2021	Molecular dynamics simulations of a visual rhodopsin indicate that the conserved hydrogen-bond network from static structure can recruit dynamic hydrogen bonds and extend throughout most of the receptor.	Hydrogen	145-153	rhodopsin	Homo sapiens	43-52
34830999-2	2021	This study aims to exploit the straightforward 1H-NMR lipoproteins analysis to investigate the alterations of the circulating lipoproteins" fractions in HER2-positive breast cancer and their modulations induced by treatments.	Hydrogen	47-49	erb-b2 receptor tyrosine kinase 2	Homo sapiens	153-157
34868265-5	2021	Modeling of all R116 substitutions in the resolved SOD1 protein structure revealed a shared mechanism with destroyed hydrogen bonds between R116 and other two residues, which might lead to protein unfolding and oligomer formation, ultimately conferring neurotoxicity.	Hydrogen	117-125	superoxide dismutase 1	Homo sapiens	51-55
34869235-6	2021	Furthermore, we calculated the light absorption characteristics of CdO/As vdW heterostructure by optical absorption spectrum and conversion efficiency of a novel solar-to-hydrogen efficiency (eta STH) about 11.67%, which is much higher than that of other 2D photocatalysts.	Hydrogen	171-179	cell adhesion associated, oncogene regulated	Homo sapiens	67-70
34824662-6	2021	The measurements are supported by density functional theory calculations providing a complete picture of the hydrogen-deficient surface of TiH2 being the basis of its high catalytic activity.	Hydrogen	109-117	RuvB like AAA ATPase 2	Homo sapiens	139-143
34830999-3	2021	The baseline 1H-NMR plasma lipoproteins profiles were measured in 43 HER2-positive breast cancer patients and compared with those of 28 healthy women.	Hydrogen	13-15	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-73
34830999-10	2021	Moreover, the lipoproteins profiles alterations induced by the therapeutic interventions could predict the clinical outcome supporting the application of 1H-NMR lipoproteins profiles analysis for longitudinal monitoring of HER2-positive breast cancer in large clinical studies.	Hydrogen	154-156	erb-b2 receptor tyrosine kinase 2	Homo sapiens	223-227
34869093-9	2021	Pro-inflammatory factors and CD16/32 in M1 macrophages were decreased, and the expression of CD16/32 in lamina propria were inhibited after treatment with hydrogen, but the changes has no effects in other tissues.	Hydrogen	155-163	Fc receptor, IgG, low affinity III	Mus musculus	29-33
34869093-9	2021	Pro-inflammatory factors and CD16/32 in M1 macrophages were decreased, and the expression of CD16/32 in lamina propria were inhibited after treatment with hydrogen, but the changes has no effects in other tissues.	Hydrogen	155-163	Fc receptor, IgG, low affinity III	Mus musculus	93-100
34746944-10	2021	Moreover, the geranate ions strongly interacted with the water molecules and thereby, eliminating the intermolecular hydrogen bonding (H-bonding) interactions towards the insulin at 0.30-0.50 mole fraction of CAGE ILs.	Hydrogen	117-125	insulin	Homo sapiens	171-178
34785728-6	2021	As a result, we found that the energetic changes in the hydrogen-bond network of the Na+ pocket, extracellular N-terminus-TM2-ECL1-TM3 interface including D2.63-K3.28 salt-bridge, and extracellular ECL2-TM5-ECL3-TM6 interface directly linked to the toggle switch contribute to the stability of CB1 by the broken aromatic interaction of the toggle switch.	Hydrogen	56-64	cannabinoid receptor 1	Homo sapiens	294-297
34719928-8	2021	The mechanism studies showed that Ery promoted the translocation of Nrf2 from cytoplasm to nucleus, and the molecular simulation docking results of Ery and Nrf2 showed that there was a hydrogen bond between them.	Hydrogen	185-193	nuclear factor, erythroid derived 2, like 2	Mus musculus	68-72
34392097-6	2021	It was proposed that these conjugates with PS as skeleton (PS-PN) dominate granular stability by affecting hydrophobicity interactions and hydrogen bonds system, which are two important parameters to gel properties, constituting a crucial finding of this work.	Hydrogen	139-147	persephin	Homo sapiens	59-64
34719928-8	2021	The mechanism studies showed that Ery promoted the translocation of Nrf2 from cytoplasm to nucleus, and the molecular simulation docking results of Ery and Nrf2 showed that there was a hydrogen bond between them.	Hydrogen	185-193	nuclear factor, erythroid derived 2, like 2	Mus musculus	156-160
34672608-3	2021	In the neutral solution, the electrocatalytic performance of the CNP@PNS-4 catalyst exhibits an onset potential of 0.98 V (vs reversible hydrogen electrode) and a half-wave potential of 0.91 V for ORR, which greatly surpasses commercial Pt/C (40%).	Hydrogen	137-145	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	65-68
34750459-5	2021	The interaction of the PBA and diol containing insulin via boronate ester bond and its interchange with glucose was investigated by FT-IR, 1H NMR and XPS.	Hydrogen	139-141	insulin	Homo sapiens	47-54
34636548-4	2021	In addition, molecular docking results revealed that the cations and organic anions of ILs bound to specific amino acid residues of AChE through noncovalent interactions such as pi interactions and hydrogen bonds.	Hydrogen	198-206	acetylcholinesterase (Cartwright blood group)	Homo sapiens	132-136
34959129-2	2022	Most routine 1H NMR spectroscopy references the chemical shift of TMS to zero.	Hydrogen	13-15	PYD and CARD domain containing	Homo sapiens	66-69
34769482-0	2021	The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration.	Hydrogen	32-40	gastrin	Mus musculus	41-44
34769482-4	2021	Hydrogen gas (H2) has been demonstrated as an antioxidant and plays a role in the regulation of oxidative stress and inflammation.	Hydrogen	0-8	gastrin	Mus musculus	9-12
34670095-3	2021	This transformation probably occurs through the hydrogen atom transfer process, and a Co(III)-six-membered cyclic intermediate is recommended.	Hydrogen	48-56	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	86-93
34778450-4	2021	1H NMR spectroscopy was carried out on the samples using Carr Purcell Meiboom Gill spin echo; also, Partial Least Squares Discriminant Analysis was performed in MATLAB software using the ProMetab program to obtain the classifying chemical shifts; the metabolites were identified by using the Human Metabolome Database (HMDB) in both the experimental and control groups.	Hydrogen	0-2	arrestin 3	Homo sapiens	57-61
34534549-6	2021	To elucidate the possible interaction between liraglutide and the DNMT1 protein, we performed an in silico study that indicates liraglutide binding in the catalytic cleft via hydrogen bonds and salt bridges with the interdomain contacts and disturbs the overall enzyme conformation.	Hydrogen	175-183	DNA methyltransferase (cytosine-5) 1	Mus musculus	66-71
34543755-8	2021	Molecular docking studies indicated that bilirubin probably interacted with P2X7R by forming hydrogen-pi interactions with residues V173, E174 and K311.	Hydrogen	93-101	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	76-81
34529977-1	2021	X-Ray crystallography shows that the hydroxyl group of Thr-45 in the fermentative alcohol dehydrogenase (ADH1) from Saccharomyces cerevisiae is hydrogen-bonded to the hydroxyl group of the alcohol bound to the catalytic zinc and is part of a proton relay system linked to His-48.	Hydrogen	144-152	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	105-109
34759379-5	2021	In phases also containing RNA polymerase II CTD, many residue types form contacts, including both cation-pi and hydrogen-bonding interactions formed by the conserved human CTD lysines.	Hydrogen	112-120	CTD	Homo sapiens	172-175
34535977-5	2021	The docking simulation revealed that the probable hydrogen bonds to FFAR4 differ between various ligands.	Hydrogen	50-58	free fatty acid receptor 4	Meleagris gallopavo	68-73
34714059-3	2021	Thanks to synergistic interactions, including hydrogen bonding, electrostatic interaction, and covalent bonding between PAA and PIP molecules, together with the increased viscosity of the solution, PIP diffusion was rationally controlled.	Hydrogen	46-54	prolactin induced protein	Homo sapiens	198-201
34746315-10	2021	Western blotting showed that hydrogen treatment reduced Bax and TNFalpha levels.	Hydrogen	29-37	tumor necrosis factor	Mus musculus	64-72
34770990-10	2021	Moreover, analysis of the binding modes of 8a,e,f into COX-2 revealed partial superposition with the co-crystallized ligand, SC-558 with the formation of essential hydrogen bonds, electrostatic, or hydrophobic interactions with the key amino acid His90 and Arg513.	Hydrogen	164-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
34746315-11	2021	Finally, cytokine assays showed that IL-2 and IL-10 levels significantly differed between the hydrogen-treated and nontreated groups.	Hydrogen	94-102	interleukin 10	Mus musculus	46-51
34746315-13	2021	Hydrogen treatment also decreased Bax and TNFalpha levels and induced an anti-inflammatory response via regulation of IL-2 and IL-10.	Hydrogen	0-8	tumor necrosis factor	Mus musculus	42-50
34746315-13	2021	Hydrogen treatment also decreased Bax and TNFalpha levels and induced an anti-inflammatory response via regulation of IL-2 and IL-10.	Hydrogen	0-8	interleukin 10	Mus musculus	127-132
34671894-7	2021	Molecular docking analysis, which was employed to make some predictions on the interaction of the most active derivatives with the binding site of Bcl-2 and Bcl-xL proteins, suggested that the compounds may be well accommodated within the binding sites of these anti-apoptotic proteins via hydrogen-bonding and hydrophobic interactions.	Hydrogen	290-298	BCL2 apoptosis regulator	Homo sapiens	147-152
34699176-6	2021	In situ high-resolution TEM observations of the decomposition process together with other analyses revealed that the nanosize effect caused by the nanoconfinement and the multiphasic interfaces between MgH2(Mg) and Ti-MX, especially the in situ formed catalytic TiH2, were main reasons accounting for the superior hydrogen sorption performances.	Hydrogen	314-322	RuvB like AAA ATPase 2	Homo sapiens	262-266
34617740-1	2021	The binding of C-4-halogenated 1-(4-X-2,5-dimethoxyphenyl)-2-aminopropane (DOX) serotonin agonist psychedelics at all three 5-HT2 receptor subtypes is up to two orders of magnitude stronger for X = Cl, Br, or I (but not F) than when C-4 bears a hydrogen atom and more than expected from their hydrophobicities.	Hydrogen	245-253	5-hydroxytryptamine receptor 2A	Homo sapiens	124-138
34610591-1	2021	N-acylated substituted beta3-oligoamides are known to form unique supramolecular nanorods based on a 3-point hydrogen-bond self-assembly motif.	Hydrogen	109-117	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	23-28
34610591-2	2021	This motif is an intermolecular extension of the hydrogen bonding network that stabilizes the 14-helix secondary structure unique to beta3-oligoamides.	Hydrogen	49-57	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	133-138
34671894-7	2021	Molecular docking analysis, which was employed to make some predictions on the interaction of the most active derivatives with the binding site of Bcl-2 and Bcl-xL proteins, suggested that the compounds may be well accommodated within the binding sites of these anti-apoptotic proteins via hydrogen-bonding and hydrophobic interactions.	Hydrogen	290-298	BCL2 like 1	Homo sapiens	157-163
34364604-4	2021	The crosslinking between CH and CHCH in cellulose modified by maleic anhydride led to the in-situ formation of a chemical crosslinking network, and hydrogen bonds acted as a sacrificial physical crosslinking network.	Hydrogen	148-156	churchill domain containing 1	Homo sapiens	32-36
34478701-11	2021	Furthermore, we found shifting populations of hydrogen bonds and salt bridges reduce pair-wise electrostatic energies within p53DBD in its DNA-bound state.	Hydrogen	46-54	tumor protein p53	Homo sapiens	125-128
34684790-4	2021	TOF-SIMS analysis evidenced that hydrogen species were introduced into the MgB2 films by using two types of ion exchangers: proton exchange resin and formic acid.	Hydrogen	33-41	secretoglobin family 2A member 1	Homo sapiens	75-79
34721070-9	2021	Unlike vitamin C, hydrogen inhalation did not blunt post-exercise mitochondrial biogenetic signals, but resulted in an increase in complex IV concentration, activation of PGC-1alpha, and TFAM and NRF-2 gene transcription, and up-regulation of PGC-1alpha protein expression.	Hydrogen	18-26	PPARG coactivator 1 alpha	Rattus norvegicus	171-181
34721070-9	2021	Unlike vitamin C, hydrogen inhalation did not blunt post-exercise mitochondrial biogenetic signals, but resulted in an increase in complex IV concentration, activation of PGC-1alpha, and TFAM and NRF-2 gene transcription, and up-regulation of PGC-1alpha protein expression.	Hydrogen	18-26	NFE2 like bZIP transcription factor 2	Rattus norvegicus	196-201
34721070-9	2021	Unlike vitamin C, hydrogen inhalation did not blunt post-exercise mitochondrial biogenetic signals, but resulted in an increase in complex IV concentration, activation of PGC-1alpha, and TFAM and NRF-2 gene transcription, and up-regulation of PGC-1alpha protein expression.	Hydrogen	18-26	PPARG coactivator 1 alpha	Rattus norvegicus	243-253
34684790-7	2021	The ion-exchange treatment using formic acid was more efficient compared to the resin treatment; with respect to the amount of hydrogen species introduced into the MgB2 films.	Hydrogen	127-135	secretoglobin family 2A member 1	Homo sapiens	164-168
34101142-0	2021	1H, 15N and 13C sequence specific backbone assignment of the MAP kinase binding domain of the dual specificity phosphatase 1 and its interaction with the MAPK p38.	Hydrogen	0-2	dual specificity phosphatase 1	Homo sapiens	94-124
34691352-15	2021	Both the relative expression levels of HO-1 and NQO1 proteins in skin specimens of cGVHD mice in the hydrogen group were lower than that in the nonhydrogen group (2.47 versus 6.21 and 1.83 versus 3.59, p < 0.05).	Hydrogen	101-109	heme oxygenase 1	Mus musculus	39-43
34691215-7	2021	Furthermore, molecular docking results showed that osthole could bind to TRPV1 with a hydrogen bond by anchoring to the amino acid residue ARG557 in the binding pocket of TRPV1.	Hydrogen	86-94	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	73-78
34691215-7	2021	Furthermore, molecular docking results showed that osthole could bind to TRPV1 with a hydrogen bond by anchoring to the amino acid residue ARG557 in the binding pocket of TRPV1.	Hydrogen	86-94	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	171-176
34355483-5	2021	The Cs 2 Pt x Sn 1-x Cl 6 solid solution with small amount of Pt 4+ substitution exhibits photocatalytic hydrogen evolution activity.	Hydrogen	105-113	solute carrier family 38 member 3	Homo sapiens	14-18
34633106-11	2022	A docking model shows that NP1 interacted primarily with TK-EGFR via hydrogen bonding.	Hydrogen	69-77	epidermal growth factor receptor	Homo sapiens	57-64
34644772-9	2021	The neuroprotective capacity of hydrogen-rich saline is partly dependent on the ROS/Nrf2/heme oxygenase-1 (HO-1) signaling pathway.	Hydrogen	32-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
34644772-9	2021	The neuroprotective capacity of hydrogen-rich saline is partly dependent on the ROS/Nrf2/heme oxygenase-1 (HO-1) signaling pathway.	Hydrogen	32-40	heme oxygenase 1	Mus musculus	89-105
34644772-9	2021	The neuroprotective capacity of hydrogen-rich saline is partly dependent on the ROS/Nrf2/heme oxygenase-1 (HO-1) signaling pathway.	Hydrogen	32-40	heme oxygenase 1	Mus musculus	107-111
34640262-2	2021	W-0.5 wt.% TiC powders with core-shell (TiC/W) structure are prepared by ball-milling and controlled hydrogen reduction processes.	Hydrogen	101-109	pleckstrin and Sec7 domain containing 4	Homo sapiens	11-14
34623713-2	2021	Herein, Co is introduced into conductive Cu-catecholate (Cu-CAT) nanorod arrays directly grown on a flexible carbon cloth for hydrogen evolution reaction (HER).	Hydrogen	126-134	catalase	Homo sapiens	60-63
34565139-7	2021	Moreover, the GV971 components mainly interact directly with the charged residues D1, R5, K16, and K28 by forming salt bridges and hydrogen bonds, which specifically bind to the N-terminal region of Abeta42.	Hydrogen	131-139	keratin 28	Homo sapiens	99-102
34101142-0	2021	1H, 15N and 13C sequence specific backbone assignment of the MAP kinase binding domain of the dual specificity phosphatase 1 and its interaction with the MAPK p38.	Hydrogen	0-2	mitogen-activated protein kinase 14	Homo sapiens	159-162
34303738-0	2021	Conformational changes and binding property of the periplasmic binding protein BtuF during vitamin B12 transport revealed by collision-induced unfolding, hydrogen-deuterium exchange mass spectrometry and molecular dynamic simulation.	Hydrogen	154-162	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	99-102
34436734-0	2021	The 1H, 15N and 13C resonance assignments of the C-terminal domain of Serpine mRNA binding protein 1 (SERBP1).	Hydrogen	4-6	SERPINE1 mRNA binding protein 1	Homo sapiens	102-108
34436734-6	2021	Here we report the production and purification of the intrinsically disordered C-terminal domain of SERBP1, the assignment of the 1H, 13C, 15N backbone resonances of the protein by solution-state NMR, and secondary structure predictions.	Hydrogen	130-132	SERPINE1 mRNA binding protein 1	Homo sapiens	100-106
34524269-9	2021	In addition, serum levels of endotoxin, syndecan-1, malondialdehyde, and tumor necrosis factor-alpha decreased, whereas superoxide dismutase levels increased, indicating that inhalation of 2% hydrogen attenuated the damage to the vascular endothelial glycocalyx through its antioxidative and anti-inflammatory effects.	Hydrogen	192-200	tumor necrosis factor	Rattus norvegicus	73-100
34264536-3	2021	The model compounds are the hydrogen-terminated diamond and graphene analogs as the typical compounds in the ideal sp3 - and sp2 -environment, respectively.	Hydrogen	28-36	Sp3 transcription factor	Homo sapiens	115-118
34264536-3	2021	The model compounds are the hydrogen-terminated diamond and graphene analogs as the typical compounds in the ideal sp3 - and sp2 -environment, respectively.	Hydrogen	28-36	Sp2 transcription factor	Homo sapiens	125-128
34638934-0	2021	Esterase Activity of Serum Albumin Studied by 1H NMR Spectroscopy and Molecular Modelling.	Hydrogen	46-48	albumin	Homo sapiens	21-34
34303738-3	2021	In the present work, conformational changes of BtuF upon B12 binding and release were investigated using hybrid approaches including collision-induced unfolding (CIU), hydrogen deuterium exchange mass spectrometry (HDX-MS) and molecular dynamics (MD) simulation.	Hydrogen	168-176	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	57-60
34543373-5	2021	This results in the nearby environment of Me2 only being composed of hydrogen atoms.	Hydrogen	69-77	malic enzyme 2	Homo sapiens	42-45
34246046-4	2021	Forty-two patients and 45 controls underwent 1H-MRS using a MEGA-PRESS sequence to quantify dACC GABA+ and Glu (contrasted against creatine (Cr)).	Hydrogen	45-47	Acetyl-CoA carboxylase	Drosophila melanogaster	92-96
34523921-5	2021	The results of 1H NMR analyses further confirmed that Ag-1 can efficiently activate hydroxyl groups and promote the reaction.	Hydrogen	15-17	thioredoxin domain containing 12	Homo sapiens	54-58
34524424-12	2021	The results predicted that SPINK3 and TESP1 had strong binding affinity, with a dock score of -430.70 and 14 hydrogen bonds as key active site residues.	Hydrogen	109-117	serine peptidase inhibitor Kazal type 1	Homo sapiens	27-33
34524424-12	2021	The results predicted that SPINK3 and TESP1 had strong binding affinity, with a dock score of -430.70 and 14 hydrogen bonds as key active site residues.	Hydrogen	109-117	protease, serine 39	Mus musculus	38-43
34684397-7	2021	Heat treatment could alter the conformations of TM allergenic peptides, impact their intramolecular hydrogen bonding, and subsequently decrease the binding between these peptides and IgE.	Hydrogen	100-108	immunoglobulin heavy constant epsilon	Homo sapiens	183-186
34641399-5	2021	Next, conventional hydrogen bonding interactions contribute to the stability of the BTS-lysozyme coupling complex.	Hydrogen	19-27	lysozyme	Homo sapiens	88-96
34569409-6	2021	Estimation of total number of intermolecular hydrogen bonds and binding free energy confirmed the stability of these Mpro-polyphenol complexes over Mpro-curcumin complex.	Hydrogen	45-53	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	117-121
34491753-5	2021	The occupied Exosite-I blocked fibrinogen binding, which prolonged fibrinogen clotting time to 28 s from 18.5 s. Molecule dynamics demonstrated the interaction of P-2-CG and thrombin Exosite-I involved in eight hydrogen bonds and lots of electrostatic forces.	Hydrogen	211-219	coagulation factor II	Mus musculus	174-182
34679660-11	2021	Thus, we propose that Arg can offer a hydrogen bond-rich, acidic-like microenvironment in RDL2 in which thiosulfate decomposes to release sulfane sulfur.	Hydrogen	38-46	thiosulfate sulfurtransferase RDL2	Saccharomyces cerevisiae S288C	90-94
34638561-6	2021	Conclusively, we propose that Nepalensinol B, characterized by the lowest free energy of binding and by a higher number of hydrogen bonds with TNF, qualifies as a potential lead compound for TNF inhibitors" drug development.	Hydrogen	123-131	tumor necrosis factor	Mus musculus	143-146
34638708-6	2021	Besides, docking results showed that compounds 2 and 5 could strongly combine with the Src homology 2 (SH2) domain of STAT3 via hydrogen bond and hydrophobic interaction, which is one of the key oncogenes and crucial therapeutic targets.	Hydrogen	128-136	signal transducer and activator of transcription 3	Homo sapiens	118-123
34548852-11	2021	Strong interactions between P3 and the Mpro active site, including four major hydrogen bonds to HIS41, ASN142, GLU166, GLN189 residues, and many hydrophobic interactions from which the interaction with CYS145 as a catalytic residue is worth mentioning.	Hydrogen	78-86	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	39-43
34449202-3	2021	The new Co(III) complexes possessed both acidic hydrogen-bond donating (HBD) NH moieties and nucleophilic counteranions and operate as bifunctional chiral catalysts for the challenging kinetic resolution of terminal and disubstituted epoxides by the reaction with CO2 under mild conditions.	Hydrogen	48-56	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	8-15
34374386-4	2021	The interaction with human serum albumin in terms of kinetic aspects, binding strength and possible binding sites was studied in detail by means of various methods such as 1H NMR spectroscopy, UV-visible spectrophotometry, steady-state and time-resolved fluorometry, ultrafiltration and capillary zone electrophoresis.	Hydrogen	172-174	albumin	Homo sapiens	27-40
34507982-6	2021	Here, we investigated the mechanism of arrestin-2 scaffolding of cRaf, MEK1, and ERK2 using hydrogen/deuterium exchange-mass spectrometry, tryptophan-induced bimane fluorescence quenching, and NMR.	Hydrogen	92-100	arrestin beta 1	Homo sapiens	39-49
34507982-6	2021	Here, we investigated the mechanism of arrestin-2 scaffolding of cRaf, MEK1, and ERK2 using hydrogen/deuterium exchange-mass spectrometry, tryptophan-induced bimane fluorescence quenching, and NMR.	Hydrogen	92-100	mitogen-activated protein kinase 1	Homo sapiens	81-85
34572383-8	2021	The binding mode analysis displayed hydrogen bond interactions with the hinge region residues Met94 and Glu95, DFG motif residue Asp155, ATP-binding site residues Thr96, Asp97, and Gln141, and quintessential residue outside the kinase domain, Cys312 of CDK7.	Hydrogen	36-44	cyclin dependent kinase 7	Homo sapiens	253-257
34541552-9	2021	To map protonation states in the hAChE active site gorge we collected 3.5 A neutron diffraction data paving the way for obtaining higher resolution datasets that will be needed to determine locations of individual hydrogen atoms.	Hydrogen	214-222	acetylcholinesterase (Cartwright blood group)	Homo sapiens	33-38
34575955-2	2021	Preliminary molecular dynamics simulations on the apo form of Mpro were performed taking into account both the hydrogen donor and acceptor natures of the Ndelta and Nepsilon of His41, a member of the catalytic dyad.	Hydrogen	111-119	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	62-66
34557512-2	2021	Fourier transform IR (FT-IR) showed that hydrogen bonds generated in BCNs/SPI colloidal particles via the anti-solvent precipitation were stronger than those generated in BCNs/SPI colloidal particles self-assembled by a simple complex method.	Hydrogen	41-49	chromogranin A	Homo sapiens	74-77
34495156-7	2021	Our results suggested that axillarin binds with the most crucial catalytic residues CYS145 and HIS41 of the Mpro, moreover axillarin shows 5 hydrogen bond interactions and 5 hydrophobic interactions with various residues of Mpro.	Hydrogen	141-149	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	108-112
34511720-2	2021	Observations of the redshifted 21-cm line of neutral hydrogen can provide valuable new insight into fundamental physics and astrophysics during these eras that no other probe can provide, and drives the design of many future ground-based instruments such as the Square Kilometre Array (SKA) and the Hydrogen Epoch of Reionization Array (HERA).	Hydrogen	53-61	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	337-341
34182093-5	2021	The docking study supported that we confirmed that compound 8h binds to DYRK1B through various hydrogen bonding interactions and hydrophobic interactions.	Hydrogen	95-103	dual specificity tyrosine phosphorylation regulated kinase 1B	Homo sapiens	72-78
34256607-4	2021	Proton MR spectroscopy (1H-MRS) estimates of dACC levels of GABA (N=67) and glutamate (N=64) were acquired before start of treatment and again approximately 14 days after randomization.	Hydrogen	24-26	Acetyl-CoA carboxylase	Drosophila melanogaster	45-49
34376064-6	2021	The objective was to externally validate the proposed cut-off, and if necessary, derive and internally as well as externally validate novel 0/3h-criteria for the observe-zone of the ESC 0/1h-hs-cTnT-algorithm in an independent multicenter cohort.	Hydrogen	188-190	troponin T2, cardiac type	Homo sapiens	194-198
34077816-4	2021	In this study, we demonstrate that the H3 peptide can be converted from nonbinder to a moderate binder of HER2 by just adding an orthogonal noncovalent interaction system (X O H) between a halogen bond (X O) and a hydrogen bond (H O) involving peptide Phe358 residue and HER2 Val948/Trp951 residues.	Hydrogen	214-222	erb-b2 receptor tyrosine kinase 2	Homo sapiens	106-110
34271119-8	2021	Both hydrophobic interactions and hydrogen bonds contributed to the 20(R, S)-PPT-EGFR binding.	Hydrogen	34-42	epidermal growth factor receptor	Homo sapiens	81-85
34473745-9	2021	An examination of the molecular docking process showed that the FCLYELAR peptide was primarily able to provide ACE-inhibitory qualities as a consequence of the hydrogen bond interactions taking place between ACE and the peptide.	Hydrogen	160-168	angiotensin I converting enzyme	Homo sapiens	111-114
34473745-9	2021	An examination of the molecular docking process showed that the FCLYELAR peptide was primarily able to provide ACE-inhibitory qualities as a consequence of the hydrogen bond interactions taking place between ACE and the peptide.	Hydrogen	160-168	angiotensin I converting enzyme	Homo sapiens	208-211
34343891-11	2021	Hydrogen bonding interactions between NEP with Zn2+and Abeta peptide confirm the degradation of the Abeta peptide.	Hydrogen	0-8	membrane metalloendopeptidase	Homo sapiens	38-41
34343891-11	2021	Hydrogen bonding interactions between NEP with Zn2+and Abeta peptide confirm the degradation of the Abeta peptide.	Hydrogen	0-8	amyloid beta precursor protein	Homo sapiens	55-60
34343891-11	2021	Hydrogen bonding interactions between NEP with Zn2+and Abeta peptide confirm the degradation of the Abeta peptide.	Hydrogen	0-8	amyloid beta precursor protein	Homo sapiens	100-105
34197882-8	2021	Molecular docking showed that both hydrogen-bonding and hydrophobic interactions helped to stabilize alpha-boswellic acid-GR binding.	Hydrogen	35-43	nuclear receptor subfamily 3 group C member 1	Homo sapiens	122-124
34273429-9	2021	Both hydrophobic and hydrogen bonding interactions play a crucial role in the stabilization between MBP and GR conducted by molecular docking and dynamics simulation.	Hydrogen	21-29	nuclear receptor subfamily 3 group C member 1	Homo sapiens	108-110
34265335-7	2021	The temperature-concentration phase diagram shows a characteristic topology with LLPS boundary metastable with respect to tetragonal microcrystals, which in turn become less stable than rod-shaped orthorhombic crystals above 40  C. Interestingly, dynamic light scattering, hydrogen-ion titrations and isothermal titration calorimetry reveal that lysozyme-HEPES interactions were found to be weakly attractive and exothermic.	Hydrogen	273-281	lysozyme	Homo sapiens	346-354
34429443-6	2021	Ligplot tool was identified the intermolecular hydrogen bonds between vaccine candidates and TLR-2, iMOD server confirmed the stability of the docking complexes.	Hydrogen	47-55	toll like receptor 2	Homo sapiens	93-98
34481534-7	2021	Molecular dynamics simulations showed that Rg3 molecules could bind stably to PTCH1 protein through hydrophobic interactions, hydrogen bonds, and pi-pi stacking forces.	Hydrogen	126-134	patched 1	Homo sapiens	78-83
34427168-8	2021	Based on the negative DeltaG , DeltaH  and DeltaS  values, the binding between azinphos-methyl and bovine serum albumin was spontaneous, and docking studies confirmed hydrogen bonding and van der Waals forces between them.Communicated by Ramaswamy H. Sarma.	Hydrogen	167-175	albumin	Homo sapiens	106-119
34402164-0	2021	Hydrogen gas inhalation ameliorates cardiac remodelling and fibrosis by regulating NLRP3 inflammasome in myocardial infarction rats.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	83-88
34836871-4	2021	Two compounds of the series 1g and 1h were found to be active against AChE whereas no derivative was active against BChE while the whole series showed excellent 1, 1-diphenyl-2-picrylhydrazyl scavenging activity.	Hydrogen	35-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74
34341816-0	2021	A NiS co-catalyst decorated Zn3In2S6/g-C3N4 type-II ball-flower-like nanosphere heterojunction for efficient photocatalytic hydrogen production.	Hydrogen	124-132	solute carrier family 5 member 5	Homo sapiens	2-5
34362978-7	2021	The binding process is spontaneous whereas hydrogen bonding interactions and van der Waals forces play a major role in the interaction between the compounds and HSA.	Hydrogen	43-51	albumin	Homo sapiens	161-164
34584766-3	2021	The parallel adtp4- ligands with an alternately reversed arrangement further link adjacent CoII ribbons into (010) layers, which are assembled into a three-dimensional supra-molecular network via inter-molecular hydrogen bonds.	Hydrogen	212-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-95
34443464-4	2021	Additionally, according to the results of pair correlation function, it turns out that H-O hydrogen bonds and H-F hydrogen bonds exist between F2311 molecules and the molecules in CL-20/TNT.	Hydrogen	91-99	chromosome 16 open reading frame 82	Homo sapiens	186-189
34443464-4	2021	Additionally, according to the results of pair correlation function, it turns out that H-O hydrogen bonds and H-F hydrogen bonds exist between F2311 molecules and the molecules in CL-20/TNT.	Hydrogen	114-122	chromosome 16 open reading frame 82	Homo sapiens	186-189
34440456-5	2021	The behaviors of mutant and native TNNI3K were compared by performing all-atom long-term molecular dynamics simulations, which revealed changes at the protein surface and in the hydrogen bond network.	Hydrogen	178-186	TNNI3 interacting kinase	Homo sapiens	35-41
34440024-9	2021	The molecular dynamics simulation confirmed the complex rigidity and stability of the docked ligand-Mpro complexes based on the analysis of mean radical variations, root-mean-square fluctuations, solvent-accessible surface area, radius of gyration, and hydrogen bond formation.	Hydrogen	253-261	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	100-104
34445264-3	2021	This is consistent with earlier drug structure-activity relationships that implicated the importance of hydrogen bonds in drug recognition by ABCB1.	Hydrogen	104-112	ATP binding cassette subfamily B member 1	Homo sapiens	142-147
34283575-4	2021	Simulations showed that NiCoSx@CoCH NAs have an optimized hydrogen adsorption free energy (DeltaGH*) of 0.02 eV, owing to the synergistic effect of CoCH (DeltaGH* = 1.36 eV) and NiCoSx (DeltaGH* = 0.03 eV).	Hydrogen	58-66	cochlin	Homo sapiens	31-35
34314184-0	2021	Protein Stability Depends Critically on the Surface Hydrogen-Bonding Network: A Case Study of Bid Protein.	Hydrogen	52-60	BH3 interacting domain death agonist	Homo sapiens	94-97
34667573-1	2021	Polymerization-induced self-assembly (PISA) is exploited to design hydrogen-bonded poly(stearyl methacrylate)-poly(benzyl methacrylate) (PSMA-PBzMA) worm gels in n-dodecane.	Hydrogen	67-75	folate hydrolase 1	Homo sapiens	137-141
34667573-4	2021	This is achieved via two complementary routes: (i) an in situ approach using binary mixtures of acid- and ester-capped PSMA stabilizer chains during PISA or (ii) a post-polymerization processing strategy using a thermally-induced worm-to-sphere transition to mix acid- and ester-functionalized spheres at 110  C that fuse to form worms on cooling to 20  C. SAXS and rheology studies of these hydrogen-bonded worm gels provide detailed insights into their inter-worm interactions and physical behavior, respectively.	Hydrogen	392-400	folate hydrolase 1	Homo sapiens	119-123
34283575-4	2021	Simulations showed that NiCoSx@CoCH NAs have an optimized hydrogen adsorption free energy (DeltaGH*) of 0.02 eV, owing to the synergistic effect of CoCH (DeltaGH* = 1.36 eV) and NiCoSx (DeltaGH* = 0.03 eV).	Hydrogen	58-66	cochlin	Homo sapiens	148-152
34149882-7	2021	Hydrogen gas post-conditioning significantly alleviated brain edema and improved neurologic function, reduced ROS production and neuronal pyroptosis, suppressed the expression of IL-1beta and IL-18 whilst upregulating ERK1/2 phosphorylation, but downregulated p38 MAPK activation 24 h post-SAH.	Hydrogen	0-8	interleukin 1 alpha	Rattus norvegicus	179-187
34350846-2	2021	The molecule crystallizes in the space group P-1, with Z = 2, and features two intramolecular sp2-C-H...N hydrogen bonds that co-operatively hold the arylethynyl molecule in a rhombus conformation.	Hydrogen	106-114	Sp2 transcription factor	Homo sapiens	94-97
34062127-5	2021	Molecular docking simulation indicated that DHT could form a hydrogen bond with catalytic site of ERp57.	Hydrogen	61-69	protein disulfide isomerase family A member 3	Homo sapiens	98-103
34242035-3	2021	The interaction at the GDYO-STAT3 interface, driven by structure matching, hydrogen bonding, and salt bridges, simultaneously triggers the immune response in the tumor microenvironment, facilitating cancer immunotherapy.	Hydrogen	75-83	signal transducer and activator of transcription 3	Homo sapiens	28-33
34281489-4	2021	The docking results showed that Leucoefdin interacted with the MPro by forming hydrogen bonds, at Leu 141, His163, His 164, and Glu 166.	Hydrogen	79-87	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	63-67
34321660-7	2021	Two amino acids-leucine 642 on GluN2A (homologous to leucine 643 on GluN2B) and asparagine 616 on GluN1-were identified as key residues that form hydrophobic and hydrogen-bond interactions with ketamine, and mutations at these residues reduced the potency of ketamine in blocking NMDA receptor channel activity.	Hydrogen	162-170	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	98-103
34281338-3	2021	We first prepare the Pd@Pt core-shell nanoparticles exposed with the Pt(100) and Pt(111) facets, respectively, via the Pd-seeded epitaxial growth, and then convert the Pd core to PdH0.43 by hydrogen intercalation.	Hydrogen	190-198	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	179-182
34319220-11	2021	The compounds exhibited good hydrogen bonds with ZIKV NS2B-NS3 protease.	Hydrogen	29-37	ns2b-ns3 protease	None	54-71
34337604-4	2021	Here, we use an expanded genetic code to examine the impact of hydrogen bonding interactions on ferryl heme structure and reactivity, by replacing the N-H group of the active site Trp51 of cytochrome c peroxidase by an S atom.	Hydrogen	63-71	cytochrome c, somatic	Homo sapiens	189-201
34400901-0	2021	Hydrogen Attenuates Myocardial Injury in Rats by Regulating Oxidative Stress and NLRP3 Inflammasome Mediated Pyroptosis.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	81-86
34232651-6	2021	For lysozyme, cardiovascular drugs were bound in the protein cavity mainly by the electrostatic and hydrogen bond interactions with residues ASP53, GLN58, ILE59, ARG62, TRP64, ASP102, and TRP109.	Hydrogen	100-108	lysozyme	Homo sapiens	4-12
34312395-4	2021	Here, we report that high-silica HY zeolite supported RuW alloy catalyst enables in situ refining of lignin, exclusively to benzene via coupling Bronsted acid catalyzed transformation of the Csp2-Csp3 bonds on the local structure of lignin molecule and RuW catalyzed hydrogenolysis of the Csp2-O bonds using the locally abstracted hydrogen from lignin molecule, affording a benzene yield of 18.8% on lignin weight basis in water system.	Hydrogen	331-339	regulator of calcineurin 2	Homo sapiens	289-293
34253022-11	2021	Hydrogen bonds are the dominant contribution to the detachment of one chain from the Abeta fibril fragment.	Hydrogen	0-8	amyloid beta precursor protein	Homo sapiens	85-90
34196520-4	2021	We have used hydrogen-deuterium exchange mass spectrometry to investigate the impact of binding of CPR and of three different substrates (7-benzyloxy-4-trifluoromethyl-coumarin, testosterone, and progesterone) on the conformational dynamics of CYP3A4.	Hydrogen	13-21	cytochrome p450 oxidoreductase	Homo sapiens	99-102
34185514-6	2021	Moreover, pH-dependent protonation exerts a significant effect on the hydrogen bonding interactions of CS9, C6U, and 6WE to BACE1, which correspondingly alters the binding abilities of the three inhibitors to BACE1.	Hydrogen	70-78	beta-secretase 1	Homo sapiens	124-129
34185514-6	2021	Moreover, pH-dependent protonation exerts a significant effect on the hydrogen bonding interactions of CS9, C6U, and 6WE to BACE1, which correspondingly alters the binding abilities of the three inhibitors to BACE1.	Hydrogen	70-78	beta-secretase 1	Homo sapiens	209-214
34251177-4	2021	The resulting a-TiO2-x/TiC exhibits a low overpotential and high H2O2 selectivity (94.1% at 0.5 V vs reversible hydrogen electrode (RHE)), and it also demonstrates robust stability with a remarkable productivity of 7.19 mol gcat.-1 h-1 at 0.30 V vs RHE.	Hydrogen	112-120	pleckstrin and Sec7 domain containing 4	Homo sapiens	23-26
34227626-8	2021	We perceive that, through hydrogen bonding and aromatic stacking interactions, Vit-C molecules interact with UA molecules.	Hydrogen	26-34	vitrin	Homo sapiens	79-82
34196520-4	2021	We have used hydrogen-deuterium exchange mass spectrometry to investigate the impact of binding of CPR and of three different substrates (7-benzyloxy-4-trifluoromethyl-coumarin, testosterone, and progesterone) on the conformational dynamics of CYP3A4.	Hydrogen	13-21	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	244-250
34275224-14	2021	The binding site of ZOL with the conformation of VEGF was located in the hydrophobic region and hydrogen-bonding region of amino acids.	Hydrogen	96-104	vascular endothelial growth factor A	Homo sapiens	49-53
34247323-5	2021	Hydrogen bond interaction with Met1160 was also found necessary for effective type II ligand binding to c-Met.	Hydrogen	0-8	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	104-109
34105527-3	2021	Under the synergistic effect of hydrogen bonding and electrostatic adsorption, Fe3O4@PANI can rapidly and easily enrich N-glycopeptides derived from standard protein (bovine fetuin and transferrin) tryptic digests and serum haptoglobin tryptic digests.	Hydrogen	32-40	serotransferrin	Bos taurus	185-196
34165113-1	2021	New van der Waals (vdW) heterostructures obtained by stacking monolayers of recently synthesized graphenylene (Gr) and two-dimensional 1H-MoX2 (X = S, Te, and Se) are proposed and analyzed using ab initio calculations.	Hydrogen	135-137	mesenchyme homeobox 2	Homo sapiens	138-142
34322022-13	2021	CC docking studies in iNOS and eNOS active site revealed hydrogen bonding of the hydroxylated chain with residues Glu377 and Glu361, involved in the substrate recognition, and explains its higher binding affinity than CA.	Hydrogen	57-65	nitric oxide synthase 2	Rattus norvegicus	22-26
34225394-3	2022	For this purpose, these novel Ag(I)-NHC complex (2) was characterized by spectroscopic techniques (1H, 13C{1H} nuclear magnetic resonance (NMR), and Fourier-transform infrared spectroscopy (FT-IR)).	Hydrogen	99-101	high mobility group nucleosomal binding domain 4	Homo sapiens	36-39
34225394-3	2022	For this purpose, these novel Ag(I)-NHC complex (2) was characterized by spectroscopic techniques (1H, 13C{1H} nuclear magnetic resonance (NMR), and Fourier-transform infrared spectroscopy (FT-IR)).	Hydrogen	107-109	high mobility group nucleosomal binding domain 4	Homo sapiens	36-39
34208928-7	2021	Based on docking experiments driven by experimental evidence, we propose a non-covalent mechanism for Mpro inhibition in which a hydrogen bond between the selenium atom and Gln189 residue in the catalytic pocket could explain the higher Mpro activity of 2d and, as a result, its better antiviral profile.	Hydrogen	129-137	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	102-106
34202468-8	2021	The secondary structures of sequence pairs showed the formation of hydrogen-bonded structures with a beta-sheet signal in FTIR spectroscopy.	Hydrogen	67-75	amyloid beta precursor protein	Homo sapiens	99-105
34210014-4	2021	All Fh-NPs interacted with HST with low affinity, and the binding was driven by hydrogen bonding and van der Waals forces for simple Fh-NPs and by hydrophobic interactions for Cu-Fh-NPs and Co-Fh-NPs binding, respectively.	Hydrogen	80-88	fibroblast growth factor 4	Homo sapiens	27-30
34132273-4	2021	In the entrance channel of SN2 a significant front-side complex formation is revealed, and in the product channel the global minimum of the title reactions is obtained at the hydrogen-bonded CH3CH2OHY- complex.	Hydrogen	175-183	solute carrier family 38 member 5	Homo sapiens	27-30
34085813-3	2021	We report photoinduced VT in benzene solvated crystals of Co(diox)2(4-CN-py)2 illuminated with blue 450 nm light at 30 K with a very high yield (80%) of metastable hs-CoII states, and we also show evidence of the de-excitation of these photoinduced metastable states using red 660 nm light.	Hydrogen	164-166	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-171
34206395-5	2021	We identify NKG2C, the HLA-Ealpha2 domain, and the nonameric peptide as the key elements involved in the molecular machinery of signal transduction via an intertwined hydrogen bond network.	Hydrogen	167-175	killer cell lectin like receptor C2	Homo sapiens	12-17
34139975-7	2022	RESULTS: The inhibitory activity of ligands against HER2 was mainly due to the strong hydrophobic and hydrogen bonding interactions.	Hydrogen	102-110	erb-b2 receptor tyrosine kinase 2	Homo sapiens	52-56
34151456-7	2022	The molecular docking method was used to explore the binding mode of compound 14p and PARP-1, and implied that the formation of hydrogen bond was essential for PARP-1 inhibition activities.	Hydrogen	128-136	poly(ADP-ribose) polymerase 1	Homo sapiens	86-92
34151456-7	2022	The molecular docking method was used to explore the binding mode of compound 14p and PARP-1, and implied that the formation of hydrogen bond was essential for PARP-1 inhibition activities.	Hydrogen	128-136	poly(ADP-ribose) polymerase 1	Homo sapiens	160-166
34222311-5	2021	First, near-infrared (NIR) spectra of Ara h1 were acquired from 25 to 80 C. Then, aquaphotomics processing tools including principal component analysis (PCA), continuous wavelet transform (CWT), and two-dimensional correlation spectroscopy (2D-COS) were utilized for better understanding the thermodynamic changes, secondary structure, and the hydrogen bond network of Ara h1.	Hydrogen	344-352	allergen Ara h 1, clone P17	Arachis hypogaea	369-375
34222311-8	2021	Moreover, it could reveal the interaction between the water structure and Ara h1 from the perspective of water molecules, and explain the effect of temperature on the Ara h1 structure and hydrogen-bonding system.	Hydrogen	188-196	allergen Ara h 1, clone P17	Arachis hypogaea	74-80
34249600-5	2021	Molecular docking studies of CAT and CGA to Keap1 kelch domain showed that they have - 9.2 kJ/mol and - 9.1 kJ/mol binding energies respectively with CAT having four hydrogen bond interactions with Keap1 while CGA had three.	Hydrogen	166-174	kelch like ECH associated protein 1	Homo sapiens	44-49
34249600-5	2021	Molecular docking studies of CAT and CGA to Keap1 kelch domain showed that they have - 9.2 kJ/mol and - 9.1 kJ/mol binding energies respectively with CAT having four hydrogen bond interactions with Keap1 while CGA had three.	Hydrogen	166-174	kelch like ECH associated protein 1	Homo sapiens	198-203
34220507-7	2021	In the binding pocket of SARS-CoV-2 Mpro, the chromone ring of Myricetin interacts with His41 through pi-pi stacking, and the 3"-, 4"- and 7-hydroxyl of Myricetin interact with Phe140, Glu166and Asp187 through hydrogen bonds.	Hydrogen	210-218	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	36-40
34076027-4	2021	The ET-1 was wrapped within the network of crosslinked GelMA hydrogels via intermolecular hydrogen bonding interactions, effectively avoiding oxidization by atmospheric oxygen and in vivo enzymatic biodegradation.	Hydrogen	90-98	endothelin 1	Homo sapiens	4-8
34075750-5	2021	When NO2 is evacuated, MOF A quickly changes from a conductor back to an insulator in 42 s. In the crystal structure of NO2-adsorbed MOF (termed as A-NO2), NO2 molecule connects Co(II) and uncoordinated carboxylate groups through hydrogen-bonding interactions to form a conductive pathway, greatly reducing the electron transmission distance between each two metal clusters.	Hydrogen	230-238	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-184
34100598-3	2021	Herein, we report an original three-dimensional self-supporting graphdiyne/molybdenum oxide (GDY/MoO3) material for efficient hydrogen evolution reaction via a rational design of "sp C-O-Mo hybridization" on the interface.	Hydrogen	126-134	surfactant protein C	Homo sapiens	180-184
34117368-5	2022	In terms of the underlying mechanism, oroxylin A may interact with histone deacetylase 1 (HDAC1) by forming hydrogen bonds with GLY149 residue and induce proteasome-mediated degradation of HDAC1 subsequently impairing HDAC1-mediated deacetylation of C/EBPbeta and promoting the expression of NAG-1.	Hydrogen	108-116	histone deacetylase 1	Homo sapiens	67-88
34117368-5	2022	In terms of the underlying mechanism, oroxylin A may interact with histone deacetylase 1 (HDAC1) by forming hydrogen bonds with GLY149 residue and induce proteasome-mediated degradation of HDAC1 subsequently impairing HDAC1-mediated deacetylation of C/EBPbeta and promoting the expression of NAG-1.	Hydrogen	108-116	histone deacetylase 1	Homo sapiens	90-95
34080416-3	2021	Noncovalent interactions including van der Waals force, hydrogen bonding, and hydrophobic effect were determined to be staple interactions between the sulfonamide metabolites and sheep serum albumin by fluorescence spectroscopy and molecular docking technology, and an 80% acetonitrile-water solution/(NH4)2SO4 was used as ATPS in order to release combined sulfonamide metabolites and minimize the influence of sheep serum albumin.	Hydrogen	56-64	albumin	Homo sapiens	185-198
34110521-1	2021	PURPOSE OF REVIEW: The sodium (Na+) and hydrogen (H+) exchanger 3 (NHE3), known as solute carrier family 9 member 3 (SLC9A3), mediates active transcellular Na+ and bicarbonate reabsorption in the small intestine of the gut and proximal tubules of the kidney.	Hydrogen	40-48	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	67-71
34110521-1	2021	PURPOSE OF REVIEW: The sodium (Na+) and hydrogen (H+) exchanger 3 (NHE3), known as solute carrier family 9 member 3 (SLC9A3), mediates active transcellular Na+ and bicarbonate reabsorption in the small intestine of the gut and proximal tubules of the kidney.	Hydrogen	40-48	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	117-123
34097593-8	2022	Molecular docking model displayed a hydrogen bond between Met-769 amide nitrogen and N-1 in pteridine motif of 7m which lay at the ATP binding site of EGFR kinase domain.	Hydrogen	36-44	epidermal growth factor receptor	Homo sapiens	151-155
34177781-14	2021	In silico analysis demonstrated that the E142A and M279R mutations in NDUFAF5 protein significantly perturbed the normal conformation of the protein due to alterations in the hydrogen bonding patterns around the evolutionarily conserved catalytic domains, leading to its loss of function in the early stage of mitochondrial complex I assembly.	Hydrogen	175-183	NADH:ubiquinone oxidoreductase complex assembly factor 5	Homo sapiens	70-77
34088839-4	2021	After confirming that LRRK2RCKW retains full kinase activity, we used hydrogen-deuterium exchange mass spectrometry to capture breathing dynamics in the presence and absence of MLi-2.	Hydrogen	70-78	leucine rich repeat kinase 2	Homo sapiens	22-27
34073489-9	2021	Structural modelling revealed that the mutation disrupts the hydrogen bonding network in the AAT shutter region.	Hydrogen	61-69	serpin family A member 1	Homo sapiens	93-96
34073781-4	2021	In silico docking and molecular interaction studies revealed the affinity and interaction of BSD with ERbeta through hydrophobic interaction and hydrogen bond pairing.	Hydrogen	145-153	estrogen receptor 1	Homo sapiens	102-108
34093209-8	2021	Molecular docking results suggested that Alp was docked into the active site of PPARgamma with the docking score of -7.6 kcal/mol, forming a hydrogen bond interaction with PPARgamma protein amino acid residue HIS449 with a bond length of 3.3 A.	Hydrogen	141-149	peroxisome proliferator activated receptor gamma	Homo sapiens	80-89
34093209-8	2021	Molecular docking results suggested that Alp was docked into the active site of PPARgamma with the docking score of -7.6 kcal/mol, forming a hydrogen bond interaction with PPARgamma protein amino acid residue HIS449 with a bond length of 3.3 A.	Hydrogen	141-149	peroxisome proliferator activated receptor gamma	Homo sapiens	172-181
34068636-5	2021	They prevent the formation of a dense bulk core and shorten the average lifetime of intramolecular hydrogen bonds in Abeta.	Hydrogen	99-107	amyloid beta precursor protein	Homo sapiens	117-122
34063471-6	2021	It seems that both alpha- and beta-CD interact with furanyl and methoxy moieties of CA, gamma-CD forms a more diverse pattern of interactions with CA, which are not observed in other CDs, whereas 2HP-beta-CD binds CA with the contribution of hydrogen bonding.	Hydrogen	242-250	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	200-207
34306816-0	2021	From Hydrogenation to Transfer Hydrogenation to Hydrogen Auto-Transfer in Enantioselective Metal-Catalyzed Carbonyl Reductive Coupling: Past, Present, and Future.	Hydrogen	48-56	EH domain containing 1	Homo sapiens	136-140
34306816-4	2021	This perspective (a) highlights past milestones in catalytic hydrogenation, hydrogen transfer and hydrogen auto-transfer, (b) summarizes current methods for catalytic enantioselective carbonyl reductive couplings, and (c) describes future opportunities based on the patterns of reactivity that animate transformations of this type.	Hydrogen	76-84	EH domain containing 1	Homo sapiens	32-36
34306816-4	2021	This perspective (a) highlights past milestones in catalytic hydrogenation, hydrogen transfer and hydrogen auto-transfer, (b) summarizes current methods for catalytic enantioselective carbonyl reductive couplings, and (c) describes future opportunities based on the patterns of reactivity that animate transformations of this type.	Hydrogen	98-106	EH domain containing 1	Homo sapiens	32-36
34090694-8	2021	Conversely, the preadministration of glutamate transporter-1 inhibitor diminished the suppression of spinal ischemia-induced glutamate increase observed during the inhalation of 3% hydrogen gas.	Hydrogen	181-189	solute carrier family 1 member 2	Rattus norvegicus	37-60
34090694-9	2021	Immunofluorescence indicated the expression of glutamate transporter-1 in the spinal ischemia group was significantly decreased compared with the sham group, which was attenuated by 3% hydrogen gas inhalation (P < .05).	Hydrogen	185-193	solute carrier family 1 member 2	Rattus norvegicus	47-70
34090694-10	2021	CONCLUSIONS: Our study demonstrated hydrogen gas inhalation exhibits a protective and concentration-dependent effect against spinal ischemic injury, and glutamate transporter-1 has an important role in the protective effects against spinal cord injury.	Hydrogen	36-44	solute carrier family 1 member 2	Rattus norvegicus	153-176
35468374-7	2022	The OCN and OCN-T molecules are obvious hydrogen bonding systems.	Hydrogen	40-48	bone gamma-carboxyglutamate protein	Homo sapiens	4-7
34123322-6	2021	1H NMR kinetic analysis of salt degradation has evidenced thermal degradation to methyl iodide and the parent aniline, consistent with a closed-shell SN2-centred degradative pathway, and methyl iodide being the key reactive species in applied methylation procedures.	Hydrogen	0-2	solute carrier family 38 member 5	Homo sapiens	150-153
34168784-2	2021	Reaction dynamics simulations on a newly developed high-level ab initio analytical potential energy surface for the F- + NH2Cl nitrogen-centered SN2 and proton-transfer reactions reveal a hydrogen-bond-formation-induced multiple-inversion mechanism undermining the stereospecificity of the N-centered SN2 channel.	Hydrogen	188-196	solute carrier family 38 member 5	Homo sapiens	145-148
34168784-2	2021	Reaction dynamics simulations on a newly developed high-level ab initio analytical potential energy surface for the F- + NH2Cl nitrogen-centered SN2 and proton-transfer reactions reveal a hydrogen-bond-formation-induced multiple-inversion mechanism undermining the stereospecificity of the N-centered SN2 channel.	Hydrogen	188-196	solute carrier family 38 member 5	Homo sapiens	301-304
34121971-9	2021	Additionally, molecular docking-study revealed that Vin competed with Nrf2 for Keap1-binding site, with hydrogen and stearic interactions.	Hydrogen	104-112	NFE2 like bZIP transcription factor 2	Homo sapiens	70-74
34121971-9	2021	Additionally, molecular docking-study revealed that Vin competed with Nrf2 for Keap1-binding site, with hydrogen and stearic interactions.	Hydrogen	104-112	kelch like ECH associated protein 1	Homo sapiens	79-84
34393447-4	2021	Results of the docking studies indicate that stevioside had more than two hydrogen bond interactions with the AKT and PPAR gamma protein for further consideration.	Hydrogen	74-82	AKT serine/threonine kinase 1	Homo sapiens	110-113
34393447-4	2021	Results of the docking studies indicate that stevioside had more than two hydrogen bond interactions with the AKT and PPAR gamma protein for further consideration.	Hydrogen	74-82	peroxisome proliferator activated receptor gamma	Homo sapiens	118-128
35417841-4	2022	Raman and Fourier transform infrared spectroscopy studies revealed that the carboxyl group of OA entered into the beta-CD cavity to form hydrogen bonds, which was confirmed by conformational search and weak interactions analysis.	Hydrogen	137-145	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	114-121
35417841-6	2022	Topological analysis showed that four moderate hydrogen bonds were formed between OA and beta-CD with the bond energy ranging from -76.05 to -30.25 kJ/mol.	Hydrogen	47-55	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	89-96
34141086-5	2021	X-ray crystallographic analysis demonstrated a key hydrogen bonding network in the P2 binding pocket of BCL-XL, while the bent-back moiety achieved efficient occupancy of the P4 pocket in a manner similar to that of navitoclax.	Hydrogen	51-59	BCL2 like 1	Homo sapiens	104-110
34927838-0	2021	Engineering Heterogeneous NiS2 /NiS Cocatalysts with Progressive Electron Transfer from Planar p-Si Photocathodes for Solar Hydrogen Evolution.	Hydrogen	124-132	solute carrier family 5 member 5	Homo sapiens	32-35
34375519-4	2021	Molecular docking simulations of ganolucidic acid A/D and ganoderic acid A/B predicted the strongest binding affinity via hydrogen bonding, suggesting the inhibition of HIV-1 gp120 attachment to CD4.	Hydrogen	122-130	CD4 molecule	Homo sapiens	195-198
35334317-6	2022	Finally, molecular docking results showed more hydrogen bonds between octanal and SPI.	Hydrogen	47-55	chromogranin A	Homo sapiens	82-85
35334317-7	2022	The results showed that aldehyde groups were more likely to interact with SPI than others, probably due to their tendency to form more hydrogen bonds.	Hydrogen	135-143	chromogranin A	Homo sapiens	74-77
35413530-3	2022	The unique spatial size and hydrophilicity of beta-CD on the surface of AgNPs could selectively capture the target molecule (NFX) through some weak interactions, including hydrogen-bond interaction, electrostatic interaction, etc.	Hydrogen	172-180	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	46-53
35217462-7	2022	Thermodynamic analysis and molecular docking results showed that the main forces present between SPI and catechin were hydrophobic interactions and hydrogen bonds.	Hydrogen	148-156	chromogranin A	Homo sapiens	97-100
35219988-4	2022	Asc - removed hydrogen atoms from amino and sulfhydryl groups, resulting in a decrease in their content.	Hydrogen	14-22	PYD and CARD domain containing	Homo sapiens	0-3
35364410-5	2022	In addition, the chelation mechanism of NPP with Al3+ ions was proposed and substantiated by the density functional theory (DFT) and time-dependent density functional theory (TD-DFT), IR spectrum and 1H NMR titration experiments.	Hydrogen	200-202	proopiomelanocortin	Homo sapiens	40-43
35219988-7	2022	Therefore, the grafting mechanism is presumed that the Asc - catches hydrogen atoms in protein-sensitive amino acids and generates macromolecular radicals that induce the formation of WPI-EGCG graft.	Hydrogen	69-77	PYD and CARD domain containing	Homo sapiens	55-58
35452649-0	2022	Hydrogen production via photoreforming of wastewater under LED light-driven over CuO@exfoliated g-C3N4 nanoheterojunction.	Hydrogen	0-8	small integral membrane protein 10 like 2A	Homo sapiens	59-62
35278280-0	2022	Hydrogen-rich and hyperoxygenate saline inhibits lipopolysaccharide-induced lung injury through mediating NF-kappaB/NLRP3 signaling pathway in C57BL/6 mice.	Hydrogen	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	106-115
35490765-4	2022	ART was linked by hydrogen bond to HP-beta-CD to form hydrophilic supramolecules, which are loaded into PS under the action of hydrogen bond.	Hydrogen	18-26	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	38-45
35490765-4	2022	ART was linked by hydrogen bond to HP-beta-CD to form hydrophilic supramolecules, which are loaded into PS under the action of hydrogen bond.	Hydrogen	127-135	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	38-45
35417087-5	2022	Structural analysis shows that phosphorylation of these serine residues increases binding affinity by producing multiple hydrogen bonds with ATG8s that cannot be mimicked by acidic residues.	Hydrogen	121-129	GABA type A receptor associated protein like 1	Homo sapiens	141-145
35613096-3	2022	The hydrocarbon tail and tetracyclic ring of cholesterol interact with the hydrophobic tunnel of OSBP, and the hydroxyl group of cholesterol forms a hydrogen bond network at the bottom of the tunnel.	Hydrogen	149-157	oxysterol binding protein	Homo sapiens	97-101
35367313-0	2022	PPARalpha contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression.	Hydrogen	51-59	peroxisome proliferator activated receptor alpha	Mus musculus	0-9
35367313-0	2022	PPARalpha contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression.	Hydrogen	51-59	cAMP responsive element binding protein 1	Mus musculus	132-136
35618679-0	2022	Fast, Sensitive, and Highly Selective Room-Temperature Hydrogen Sensing of Defect-Rich Orthorhombic Nb2O5-x Nanobelts with an Abnormal p-Type Sensor Response.	Hydrogen	55-63	Fas activated serine/threonine kinase	Homo sapiens	0-4
35149868-4	2022	Modelled on the ESC hs-cTnT/I 0/1h-algorithms, we derived a 0/1h-cMyC-algorithm.	Hydrogen	62-64	troponin T2, cardiac type	Homo sapiens	23-27
35418544-6	2022	Furthermore, translocation of Bax to mitochondria was associated with the release of Cytochrome C. Molecular docking analysis revealed three hydrogen-bonds existed in Compound 3 with PARP receptor (PDB code: 5DSY), which may be the target of the anti-ovarian cancer effect of Compound 3.	Hydrogen	141-149	BCL2 associated X, apoptosis regulator	Homo sapiens	30-33
35272121-9	2022	Fluorescence assay and molecular docking indicated that hydrogen bond and electrostatic gravitation were the main forces between the two 5-LOX and SOG.	Hydrogen	56-64	arachidonate 5-lipoxygenase	Homo sapiens	137-142
35418544-6	2022	Furthermore, translocation of Bax to mitochondria was associated with the release of Cytochrome C. Molecular docking analysis revealed three hydrogen-bonds existed in Compound 3 with PARP receptor (PDB code: 5DSY), which may be the target of the anti-ovarian cancer effect of Compound 3.	Hydrogen	141-149	PDB1	Homo sapiens	198-201
35536915-0	2022	1H-Detected Biomolecular NMR under Fast Magic-Angle Spinning.	Hydrogen	0-2	Fas activated serine/threonine kinase	Homo sapiens	35-39
35351434-5	2022	Furthermore, the mutant AR failed to bind to ligand due to the loss of hydrogen bond with dihydrotestosterone (DHT).	Hydrogen	71-79	androgen receptor	Homo sapiens	24-26
35557499-0	2022	Hydrogen-Bond Disrupting Electrolytes for Fast and Stable Proton Batteries.	Hydrogen	0-8	Fas activated serine/threonine kinase	Homo sapiens	42-46
35346675-5	2022	Secondly, molecular dynamics simulations of heterodimeric STAT3-PIM1 complex with curcumin revealed binding of curcumin on PIM-1 interface of the complex through hydrogen bonds (Asp155) and hydrophobic interactions (Leu13, Phe18, Val21, etc.)	Hydrogen	162-170	signal transducer and activator of transcription 3	Homo sapiens	58-63
35346675-5	2022	Secondly, molecular dynamics simulations of heterodimeric STAT3-PIM1 complex with curcumin revealed binding of curcumin on PIM-1 interface of the complex through hydrogen bonds (Asp155) and hydrophobic interactions (Leu13, Phe18, Val21, etc.)	Hydrogen	162-170	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	64-68
35346675-5	2022	Secondly, molecular dynamics simulations of heterodimeric STAT3-PIM1 complex with curcumin revealed binding of curcumin on PIM-1 interface of the complex through hydrogen bonds (Asp155) and hydrophobic interactions (Leu13, Phe18, Val21, etc.)	Hydrogen	162-170	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	123-128
35610266-4	2022	We show the Rev1 R324 protein-template forms sub-optimal hydrogen bonds with incoming dTTP, dGTP, and dATP that prevents Rev1 from adopting a catalytically competent conformation.	Hydrogen	57-65	REV1 DNA directed polymerase	Homo sapiens	121-125
35609013-0	2022	Morphology Tuned Pt3 Ge Accelerates Water Dissociation to Industrial Standard Hydrogen Production over a wide pH Range.	Hydrogen	78-86	zinc finger protein 135	Homo sapiens	17-20
35609013-2	2022	We introduce a novel electrocatalyst, Pt3 Ge, engineered with a desired crystallographic facet (202) accelerates hydrogen production by water electrolysis and records industrially desired operational stability compared to the commercial catalyst platinum.	Hydrogen	113-121	zinc finger protein 135	Homo sapiens	38-41
35609013-5	2022	Pt3 Ge-(202) also displayed low overpotential of 96 mV for 10 mA/cm2 current density in the alkaline medium, rationalizing its hydrogen production ability over a wide pH range required commercial operations.	Hydrogen	127-135	zinc finger protein 135	Homo sapiens	0-3
35596855-6	2022	The CEA aptamer on AuNPs can be adsorbed onto the surface of UCNPs@PDA due to the interactions of pi-pi stacking and hydrogen bonding, triggering the process of fluorescence resonance energy transfer (FRET) from UCNPs@PDA to AuNPs-CEA aptamer.	Hydrogen	117-125	CEA cell adhesion molecule 3	Homo sapiens	4-7
35604200-3	2022	The reaction exhibits a normal secondary kinetic isotope effect ( k 1H / k 1D = 1.065+-0.026) with a beta,gamma-deuterated substrate.	Hydrogen	68-70	amyloid beta precursor protein	Homo sapiens	99-105
35624145-3	2022	Thirteen kinases were found to activate sodium/hydrogen exchanger (NHE1) in normal hematopoietic progenitors, of which FLT3-ITD, KRASG12D, and BTK phosphorylated NHE1 maintained alkaline intracellular pH (pHi) and supported survival of AML cells.	Hydrogen	47-55	solute carrier family 9 member A1	Homo sapiens	67-71
35624145-3	2022	Thirteen kinases were found to activate sodium/hydrogen exchanger (NHE1) in normal hematopoietic progenitors, of which FLT3-ITD, KRASG12D, and BTK phosphorylated NHE1 maintained alkaline intracellular pH (pHi) and supported survival of AML cells.	Hydrogen	47-55	fms related receptor tyrosine kinase 3	Homo sapiens	119-123
35624145-3	2022	Thirteen kinases were found to activate sodium/hydrogen exchanger (NHE1) in normal hematopoietic progenitors, of which FLT3-ITD, KRASG12D, and BTK phosphorylated NHE1 maintained alkaline intracellular pH (pHi) and supported survival of AML cells.	Hydrogen	47-55	solute carrier family 9 member A1	Homo sapiens	162-166
35503527-5	2022	The results of 1H NMR spectroscopy, EPR measurements, and DFT calculations revealed that SpI is generated via three steps: (1) intramolecular hydrogen transfer from the tBu group to the nitrogen atom of the imidazole ring, (2) intramolecular cyclization of alkyl radicals, and (3) intermolecular hydrogen transfer with another tBu-TPIR.	Hydrogen	15-17	chromogranin A	Homo sapiens	89-92
35503527-5	2022	The results of 1H NMR spectroscopy, EPR measurements, and DFT calculations revealed that SpI is generated via three steps: (1) intramolecular hydrogen transfer from the tBu group to the nitrogen atom of the imidazole ring, (2) intramolecular cyclization of alkyl radicals, and (3) intermolecular hydrogen transfer with another tBu-TPIR.	Hydrogen	142-150	chromogranin A	Homo sapiens	89-92
35503527-5	2022	The results of 1H NMR spectroscopy, EPR measurements, and DFT calculations revealed that SpI is generated via three steps: (1) intramolecular hydrogen transfer from the tBu group to the nitrogen atom of the imidazole ring, (2) intramolecular cyclization of alkyl radicals, and (3) intermolecular hydrogen transfer with another tBu-TPIR.	Hydrogen	296-304	chromogranin A	Homo sapiens	89-92
35507916-4	2022	Herein, we set out to determine the relative roles of hydrogen bonds involved in ET via an established heme-to-surface tunneling pathway in cytochrome (cyt) c (i.e., heme-W59-D60-E61-N62).	Hydrogen	54-62	cytochrome c, somatic	Homo sapiens	140-158
35506927-7	2022	Specifically, the addition of TNT molecules in the CL-20/TNT co-crystal introduces intermolecular hydrogen bonds between CL-20 and TNT molecules in the system, thereby increasing the thermal stability of the co-crystal.	Hydrogen	98-106	epithelial membrane protein 1	Homo sapiens	51-56
35506927-7	2022	Specifically, the addition of TNT molecules in the CL-20/TNT co-crystal introduces intermolecular hydrogen bonds between CL-20 and TNT molecules in the system, thereby increasing the thermal stability of the co-crystal.	Hydrogen	98-106	epithelial membrane protein 1	Homo sapiens	121-126
35578172-6	2022	RESULTS: Docking analysis using PyRx version 0.8 along with AutoDockVina reveals that among the screened phyto compounds, Genistein shows the maximum binding affinity towards the hydrophobic substrate-binding site of TMPRSS2 with three hydrogen bonds interaction ( - 7.5 kcal/mol).	Hydrogen	236-244	transmembrane serine protease 2	Homo sapiens	217-224
35581255-3	2022	In order to elucidate the structure of perm beta-CD)/LysH+ complex in the gas phase, we carry out quantum chemical calculations to assign the two strong peaks at 3,340 and 3,560 cm-1 in the IRMPD spectrum, finding that the carboxyl forms loose hydrogen bonding with the perm beta-CD, whereas the ammonium group of L-Lysine is away from the perm beta-CD unit.	Hydrogen	244-252	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	44-51
35578853-8	2022	RESULTS: In the tested example, SEPA bash script was able to identify the tripeptide YYH ranked within top 20 based on the essential hydrogen bond interaction towards the essential amino acid residue ASP837 in the EGFR-TK receptor.	Hydrogen	133-141	epidermal growth factor receptor	Homo sapiens	214-218
35578172-7	2022	On the other hand, molecular docking analysis using Schrodinger identified Quercetin as the most potent phyto compound with a maximum binding affinity towards the hydrophilic catalytic site of TMPRSS2 ( - 7.847 kcal/mol) with three hydrogen bonds interaction.	Hydrogen	232-240	transmembrane serine protease 2	Homo sapiens	193-200
35119839-3	2022	Hydrogen bonding of bovine serum albumin with electroneutral PhG NPs endows them with additional ligand binding affinity and enables the electrostatically governed attachment of methotrexate (MTX), a therapeutic agent commonly used in the treatment of cancer and arthritis diseases, to the protein-capped NPs.	Hydrogen	0-8	albumin	Homo sapiens	27-40
35319201-2	2022	Here, we use direct ab initio molecular dynamics simulations at accelerated temperatures and hydrogen pressures to probe the hydrogenation chemistry of the candidate material MgB2 without a priori assumption of reaction pathways.	Hydrogen	93-101	secretoglobin family 2A member 1	Homo sapiens	175-179
35319201-7	2022	Our results provide guidance for devising kinetic improvement strategies for MgB2-based hydrogen storage materials, while also providing a template for exploring chemical pathways in other solid-state energy storage reactions.	Hydrogen	88-96	secretoglobin family 2A member 1	Homo sapiens	77-81
35471922-9	2022	The polymer formed multiple hydrogen bonds with the polar and charged amino acid residues of the glucagon molecule, shielding the peptide surface from aggregation.	Hydrogen	28-36	glucagon	Homo sapiens	97-105
35441652-8	2022	Meanwhile, molecular docking results showed that the strong binding force of CA and PI3K was due to the higher number of hydrogen- and pi-bonds with active site residues.	Hydrogen	121-129	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	77-79
35527546-10	2022	The number of hydrogen bonds was such that the flexibility of the enzyme protein structure due to inhibitor binding reduced AChE function.	Hydrogen	14-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	124-128
35149482-6	2022	The binding constants of AuNPs with proteins are in the range from 106 to 1010 L mol-1, and the order is pepsin > gamma-globulin > hemoglobin > trypsin > lysozyme at 298 K. Van der Waals forces and hydrogen bonds are the main forces for the lysozyme-AuNPs system.	Hydrogen	198-206	lysozyme	Homo sapiens	154-162
35467876-0	2022	Theoretical, Semiempirical, and Experimental Solvatochromic Comparison Methods for the Construction of the alpha1 Scale of Hydrogen-Bond Donation of Solvents.	Hydrogen	123-131	BCL2 related protein A1	Homo sapiens	107-113
35341785-0	2022	Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress.	Hydrogen	0-8	angiotensin II receptor, type 1b	Rattus norvegicus	86-116
35341785-5	2022	Serum brain natriuretic peptide expression was also attenuated by hydrogen treatment.	Hydrogen	66-74	natriuretic peptide B	Rattus norvegicus	6-31
35341785-8	2022	Additionally, western blotting results showed that hydrogen inhalation inhibited the expression of cardiac nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2), angiotensin II type 1 receptor, sarcoplasmic reticulum Ca2+-ATPase (SERCA2), phospho-phospholamban and alpha-myosin heavy chain proteins.	Hydrogen	51-59	angiotensin II receptor, type 1b	Rattus norvegicus	169-199
35441632-6	2022	The conformational changes, including the A-loop alpha-structure breaking and the stronger hydrogen bond network formation, are accompanied by the extension of the A-loop and more intramolecular interactions in p38alpha.	Hydrogen	91-99	mitogen-activated protein kinase 14	Homo sapiens	211-219
35389096-0	2022	Epitope mapping of antibodies in C-reactive protein assay kits by hydrogen-deuterium exchange mass spectrometry explains differential results across kits.	Hydrogen	66-74	C-reactive protein	Homo sapiens	33-51
35217022-4	2022	MP12 sequence showed a significant binding score and has multiple hydrogen bond interactions with the proteins that play a vital role in apoptotic pathways such as Bcl-2, caspase-3, caspase-7, and XIAP.	Hydrogen	66-74	BCL2 apoptosis regulator	Homo sapiens	164-169
35227839-6	2022	1H-NMR analyses revealed the complex formation considering the shifts of the protons of the APIs as well as HP-beta-CD.	Hydrogen	0-2	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	111-118
35378129-4	2022	As elucidated in our 2.37 A crystal structure, SETMAR forms a dimeric complex with each DNA-binding domain bound specifically to TIR-DNA through the formation of 32 hydrogen bonds.	Hydrogen	165-173	SET domain and mariner transposase fusion gene	Homo sapiens	47-53
35307397-4	2022	To understand how LPL binds ANGPTL3/8 and ApoA5 blocks this interaction, we used hydrogen-deuterium exchange mass-spectrometry (HDXMS) and molecular modeling to map binding sites of LPL and ApoA5 on ANGPTL3/8.	Hydrogen	81-89	angiopoietin like 3	Homo sapiens	28-37
35307397-4	2022	To understand how LPL binds ANGPTL3/8 and ApoA5 blocks this interaction, we used hydrogen-deuterium exchange mass-spectrometry (HDXMS) and molecular modeling to map binding sites of LPL and ApoA5 on ANGPTL3/8.	Hydrogen	81-89	apolipoprotein A5	Homo sapiens	42-47
35289053-4	2022	The thermodynamic parameters obtained at different temperatures showed van der Waals" interactions and hydrogen bonds played the main roles in the interaction of myricetin with trypsin and lysozyme, hydrophobic force was dominant both in myricetin with alpha-chymotrypsin interaction and dihydromyricetin with trypsin and lysozyme interaction, as for the electrostatic forces, it was the mainly driving force in dihydromyricetin binding to alpha-chymotrypsin.	Hydrogen	103-111	lysozyme	Homo sapiens	189-197
35341807-10	2022	The molecular docking analysis suggested that PBD-2 interacted with porcine SLC25A4 mainly through strong hydrogen binding, with the predicted binding affinity being -13.23 kcal/mol.	Hydrogen	106-114	defensin beta 1	Sus scrofa	46-51
35063548-1	2022	To develop a zero energy consumption electrokinetic remediation method of Pb(II) in water and soil, a primary cell system was constructed via synergistic effects of the electromigration, ion exchange, precipitation and hydrogen bond.	Hydrogen	219-227	submaxillary gland androgen regulated protein 3B	Homo sapiens	74-80
35593213-7	2022	Specifically, compared to PRE, a significant increase in ET-1 was observed at 1H (p = 0.017) and 3H (p = 0.025).	Hydrogen	78-80	endothelin 1	Homo sapiens	57-61
35593213-8	2022	In addition, concentrations of ET-1 were significantly lower at 24H compared to PRE (p = 0.019), 1H (p < 0.001), and 3H (p < 0.001).	Hydrogen	97-99	endothelin 1	Homo sapiens	31-35
35566232-9	2022	We found that TDD can directly bind to Cav1 through hydrogen bonds and van der Waals forces.	Hydrogen	52-60	caveolin 1	Homo sapiens	39-43
35582645-7	2022	In addition, the R47H mutant reduced the interaction between ApoE and TREM2 protein, which may be attributed to decreased hydrogen-bonding interactions, hydrophobic interactions, and electrostatic forces between ApoE and TREM2.	Hydrogen	122-130	apolipoprotein E	Homo sapiens	61-65
35582645-7	2022	In addition, the R47H mutant reduced the interaction between ApoE and TREM2 protein, which may be attributed to decreased hydrogen-bonding interactions, hydrophobic interactions, and electrostatic forces between ApoE and TREM2.	Hydrogen	122-130	triggering receptor expressed on myeloid cells 2	Homo sapiens	70-75
35380691-0	2022	Hydrogen-deuterium exchange mass spectrometry of Mtr4 with diverse RNAs reveals substrate-dependent dynamics and interfaces in the arch.	Hydrogen	0-8	ATP-dependent RNA helicase MTR4	Saccharomyces cerevisiae S288C	49-53
35490326-7	2022	Binding mode analysis showed that hydrogen bond, hydrophobic and pi-pi stacking interactions dominated the bindings of these compounds to Pim-1.	Hydrogen	34-42	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	138-143
35528164-0	2022	Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway.	Hydrogen	10-18	AKT serine/threonine kinase 1	Homo sapiens	61-64
35452465-11	2022	All three imidazoquinoline derivatives can form stable hydrogen bonds with D555 of TLR7 and the corresponding D543 of TLR8.	Hydrogen	55-63	toll like receptor 7	Homo sapiens	83-87
35452465-11	2022	All three imidazoquinoline derivatives can form stable hydrogen bonds with D555 of TLR7 and the corresponding D543 of TLR8.	Hydrogen	55-63	toll like receptor 8	Homo sapiens	118-122
35504219-5	2022	Protein coupling analysis revealed that the three mutants favour the robust binding of LPXN than the wild type by altering the hydrogen bonding network.	Hydrogen	127-135	leupaxin	Homo sapiens	87-91
35467350-6	2022	The docking calculations and molecular dynamics simulations showed how 1 enters the PSMA funnel region and how pharmacophore Glu-urea-Lys interacts with the arginine patch, the S1", and S1 subpockets by forming hydrogen and van der Waals bonds.	Hydrogen	211-219	folate hydrolase 1	Homo sapiens	84-88
35229489-7	2022	Among the three molecules, asymmetric CoII porphyrin (as-PorCo) showed the lowest onset potential of -288 mV and faradaic efficiencies exceeding 93 % at -0.6 V vs. reversible hydrogen electrode, which is highly competitive among the reported state-of-art porphyrin-based electrocatalysts.	Hydrogen	175-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
35514347-1	2022	The sodium (Na+)/hydrogen (H+) exchanger 3 (NHE3) is one of the most important Na+/H+ antiporters in the small intestines of the gastrointestinal tract and the proximal tubules of the kidney.	Hydrogen	17-25	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	44-48
35420470-8	2022	X-ray crystallographic studies, molecular docking, and molecular dynamics simulations of the OXA-23-MA-1-206 complex show that the C6 hydroxymethyl group forms a hydrogen bond with the carboxylated catalytic lysine of OXA-23, effectively preventing deacylation.	Hydrogen	162-170	class D beta-lactamase OXA-23	Acinetobacter baumannii	93-99
35296453-7	2022	The lead inhibitor interacted with FAAH and MAGL via pi-pi stacking via phenyl ring and hydrogen bonding through sulfonyl oxygen atoms or amide NH.	Hydrogen	88-96	fatty acid amide hydrolase	Homo sapiens	35-39
35420470-8	2022	X-ray crystallographic studies, molecular docking, and molecular dynamics simulations of the OXA-23-MA-1-206 complex show that the C6 hydroxymethyl group forms a hydrogen bond with the carboxylated catalytic lysine of OXA-23, effectively preventing deacylation.	Hydrogen	162-170	class D beta-lactamase OXA-23	Acinetobacter baumannii	218-224
35425086-4	2022	Our results suggest that resveratrol binds to the MBD proteins with higher binding affinity toward MeCP2 protein (DeltaG = -6.5) by sharing four hydrogen bonds as predicted by molecular docking studies.	Hydrogen	145-153	methyl-CpG binding protein 2	Homo sapiens	99-112
35417618-8	2022	Host-guest complexation studies show that macrocycle BP1 decorated interior OH moieties could strongly encapsulate neutral guests by forming inner hydrogen bonds, giving a high association constant of 4.59x10 4 M -1 in non-polar media.	Hydrogen	147-155	BP1	Homo sapiens	53-56
35380142-3	2022	With the analyses of non-covalent intermolecular interactions including the quantum theory of atoms, Johnson"s non-covalent interactions and natural bond orbital, the observed global minimum is stabilized by a combination of one sp2-C O tetrel bond and a network of multiple C-H O weak hydrogen bonds.	Hydrogen	286-294	Sp2 transcription factor	Homo sapiens	229-232
35479493-8	2022	Elevated serum IL-6 levels were associated with increased Glx levels in left HPC, left MTC, and right DLPFC, after processing the 1H-MRS data with Tarquin.	Hydrogen	130-132	interleukin 6	Homo sapiens	15-19
35444425-3	2022	Methods: The pharmacophore features consisted of seven features, ie, three hydrophobic, one negative ion, and three hydrogen bond acceptors, which were developed based on the structure of COX-2 inhibitor, (R)-naproxen.	Hydrogen	116-124	prostaglandin-endoperoxide synthase 2	Homo sapiens	188-193
35381900-9	2022	The data obtained from hydrogen bond analysis revealed a more equilibrated and stable form of the ClyA-affiEGFR-GALA structure upon interaction with EGFR.	Hydrogen	23-31	epidermal growth factor receptor	Homo sapiens	149-153
35408774-4	2022	At the catalytic site of COX-2, docking protocols with ChemPLP, GoldScore and AutoDock scoring functions were carried out to reveal hydrogen bonding interactions with key polar contacts and hydrophobic pi-interactions.	Hydrogen	132-140	prostaglandin-endoperoxide synthase 2	Homo sapiens	25-30
35227978-6	2022	The results of molecular docking and dynamics study demonstrated that compound 21 formed four key hydrogen bonds with c-Met kinase.	Hydrogen	98-106	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	118-123
35458602-7	2022	The molecular docking simulation indicated that the binding pattern of 3s into PI3Kgamma was preferable than that of PI3Kalpha, with more hydrogen bond, more pi-involved interactions, and fewer pi-sulfur interactions.	Hydrogen	138-146	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	117-126
35507105-6	2022	We found that glycan-involved hydrogen bonds and glycan-dimer occlusion were useful metrics predicting the proteolytic stability and dimerization propensity of insulin, respectively, as was in part the solvent-accessible surface area of proteolytic sites.	Hydrogen	30-38	insulin	Homo sapiens	160-167
35383180-5	2022	We identify specific contacts between SUMO2 and the USPL1 subdomains, including a unique hydrogen bond network of the SUMO2 C-terminal tail.	Hydrogen	89-97	ubiquitin specific peptidase like 1	Homo sapiens	52-57
35168158-6	2022	Docking experiments showed that, compounds 7c, 7o and 7 v bind within active sites of epidermal growth factor receptor EGFR (Pdb ID: 6P8Q) by strong hydrogen bonds with residue MET793, Pi-Sulfur with residue MET790 and Pi-Alkyl type interactions with residues LEU788, ALA743.	Hydrogen	149-157	PDB1	Homo sapiens	125-128
35362514-8	2022	IL-1beta and IL-6 were up-regulated after 1h, but IL-1beta decreased right after 3h, while IL-6 sustained up-regulation throughout all time points.	Hydrogen	42-44	interleukin 6	Homo sapiens	13-17
35061233-6	2022	The dynamics of this domain was obtained, and our hydrogen-deuterium exchange experiment reveals that the first helix in BIR1 is exposed to the solvent.	Hydrogen	50-58	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	121-125
35362361-9	2022	The network of hydrogen bonds for the intramolecular protein secondary structure and with the solvent system for the apo-protein and the uPA-ligand complex was found to be consistent.Communicated by Ramaswamy H. Sarma.	Hydrogen	15-23	plasminogen activator, urokinase	Homo sapiens	137-140
35129312-0	2022	Interfacial Electron Transfer Strategy to Improve the Hydrogen Evolution Catalysis of CrP Heterostructure.	Hydrogen	54-62	C-reactive protein	Homo sapiens	86-89
35038671-2	2022	In this study, the associations of posterior cingulate gyrus tau and amyloid beta (Abeta) deposition on PET with 1H MRS metabolite ratios acquired from bilateral posterior cingulate gyri were investigated in cognitively unimpaired older adults.	Hydrogen	113-115	amyloid beta precursor protein	Homo sapiens	69-81
35038671-2	2022	In this study, the associations of posterior cingulate gyrus tau and amyloid beta (Abeta) deposition on PET with 1H MRS metabolite ratios acquired from bilateral posterior cingulate gyri were investigated in cognitively unimpaired older adults.	Hydrogen	113-115	amyloid beta precursor protein	Homo sapiens	83-88
35199465-6	2022	The fabricated Ag1 /CN SAC proved a higher efficiency for photocatalytic hydrogen evolution activity (3690 mummol g-1 h-1 ) than Pt nanoparticles on CN (3192 mummol g-1 h-1 ).	Hydrogen	73-81	thioredoxin domain containing 12	Homo sapiens	15-18
35307952-0	2022	Superior Dehydrogenation Performance of alpha-AlH3 Catalyzed by Li3 N: Realizing 8.0 wt.% Capacity at 100  C. The high dehydrogenation temperature of aluminum hydride (AlH3 ) has always been an obstacle to its application as a portable hydrogen source.	Hydrogen	236-244	cytochrome P450 family 4 subfamily F member 22	Homo sapiens	64-67
35224845-0	2022	Ruthenium Complex of sp2 Carbon-Conjugated Covalent Organic Frameworks as an Efficient Electrocatalyst for Hydrogen Evolution.	Hydrogen	107-115	Sp2 transcription factor	Homo sapiens	21-24
35129312-5	2022	Density functional theory (DFT) calculations suggest that electronic modulation at the interface (CrP/NPC) optimizes the hydrogen adsorption energy.	Hydrogen	121-129	C-reactive protein	Homo sapiens	98-101
35409252-6	2022	The complex structures revealed that these inhibitors formed an extra hydrogen bond to AF9, with respect to known ENL inhibitors.	Hydrogen	70-78	MLLT3 super elongation complex subunit	Homo sapiens	87-90
35091222-0	2022	Hydrogen atom abstraction mechanism for organic compound oxidation by acetylperoxyl radical in Co(II)/peracetic acid activation system.	Hydrogen	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
35411221-8	2022	Given the increased water-solubility, hydrogen bonds were found on Ala262 and Ile347 residues in the docked complex of derivative (HD2) to produce more steady interaction and initiate signaling pathways that were not observed in the case of heliomycin.	Hydrogen	38-46	histone deacetylase 2	Homo sapiens	131-134
35346014-9	2022	The studied molecules interacted with the active site of AChE through hydrophobic and hydrogen bonds and with NOS through hydrogen interactions only but in a meaningful manner.	Hydrogen	86-94	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-61
35023611-0	2022	Binary Solvent Regulated Architecture of Ultra-Microporous Hydrogen-Bonded Organic Frameworks with Tunable Polarization for Highly-Selective Gas Separation.	Hydrogen	59-67	PAXIP1 associated glutamate rich protein 1	Homo sapiens	141-144
35408551-5	2022	As the vibration energy transfer is the bridge of the intermolecular interactions, the weak intermolecular interactions were visualized using the IGMH method, and the results demonstrate that the intermolecular non-covalent interactions of TNT/CL-20 include van der Waals (vdW) interactions and hydrogen bonds, while the intermolecular non-covalent interactions of HMX/CL-20 are mainly comprised of vdW interactions.	Hydrogen	295-303	epithelial membrane protein 1	Homo sapiens	244-249
35315740-6	2022	We conducted two parallel simulation experiments where EBAI was intentionally destabilized to demonstrate its high-affinity recognition potential of the BHRF1 pocket, which binds BH3.Thus, although the potential inhibitor was in close proximity to the site of interaction, it contacted it only through orientation interactions (hydrogen and Coulomb interactions).	Hydrogen	328-336	apoptosis regulator BHRF1	Human gammaherpesvirus 4	153-158
35424731-3	2022	This effect was explained as dependent on the ratio (ArO-)/(ArOH) and for diluted ArOH corresponds to an increased contribution of much faster electron transfer (ET, ArO-/dpph ) over the Hydrogen Atom Transfer (HAT, ArOH/dpph ).	Hydrogen	187-195	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	53-56
35315040-6	2022	Bioinformatics analysis predicted that the leucine at position 253 was highly conserved among various species, and the c.758T>A variant may impact the formation of hydrogen bonds between Leu253 and Asp249 and Met257 residues, which in turn may affect the combination of GTP/GDP and function of the TUBB2B protein.	Hydrogen	164-172	tubulin beta 2B class IIb	Homo sapiens	298-304
35335157-3	2022	The molecular docking showed the hydrogen bonding and hydrophobic interactions of all the compounds in the pocket of SARS-CoV-2 main protease (Mpro), which plays an important role for the division and proliferation of the virus into the cell.	Hydrogen	33-41	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	143-147
35335160-7	2022	The interaction mode further revealed that the hydrogen bonding (via the C-7 amide or C-9 carbonyl group) and hydrophobic effect (at ring A or C) were both responsible for ZO-1-related gastrointestinal toxicity of COL analogues, while metabolic transformation via phase I and/or phase II reaction would significantly attenuate the gastrointestinal toxicity of colchicine, indicating an effective detoxication pathway through metabolism.	Hydrogen	47-55	tight junction protein 1	Homo sapiens	172-176
35244034-5	2022	The physiological and biochemical indexes, including immune inflammation indicators, electrolytes, myocardial enzyme profile, and functions of liver and kidney, were examined and investigated before and after hydrogen-oxygen therapy.The results showed significant decreases in the neutrophil percentage and the concentration and abnormal proportion of C-reactive protein in COVID-19 patients received additional hydrogen-oxygen therapy.This novel therapeutic may alleviate clinical symptoms of COVID-19 patients by suppressing inflammation responses.	Hydrogen	209-217	C-reactive protein	Homo sapiens	352-370
35171175-0	2022	Two Co(II)/Ni(II) complexes based on nitrogenous heterocyclic ligands as high-performance electrocatalysts for the hydrogen evolution reaction.	Hydrogen	115-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
35260173-5	2022	The contact of QDs with PTM (prothrombin), PLG (plasminogen) and FIB (fibrinogen) which are primary coagulation-related proteins in the coagulation and fibrinolysis systems formed QDs-protein conjugates through hydrogen-bonding and hydrophobic interaction.	Hydrogen	211-219	coagulation factor II, thrombin	Homo sapiens	29-40
35260173-5	2022	The contact of QDs with PTM (prothrombin), PLG (plasminogen) and FIB (fibrinogen) which are primary coagulation-related proteins in the coagulation and fibrinolysis systems formed QDs-protein conjugates through hydrogen-bonding and hydrophobic interaction.	Hydrogen	211-219	fibrinogen beta chain	Homo sapiens	65-68
35260173-5	2022	The contact of QDs with PTM (prothrombin), PLG (plasminogen) and FIB (fibrinogen) which are primary coagulation-related proteins in the coagulation and fibrinolysis systems formed QDs-protein conjugates through hydrogen-bonding and hydrophobic interaction.	Hydrogen	211-219	fibrinogen beta chain	Homo sapiens	70-80
35300173-0	2022	Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway.	Hydrogen	19-27	NFE2 like bZIP transcription factor 2	Homo sapiens	106-111
35300173-11	2022	Besides, hydrogen-rich medium relieved the oxidative stress via the activation of the Nrf-2/heme oxygenase-1 (HO-1) pathway.	Hydrogen	9-17	NFE2 like bZIP transcription factor 2	Homo sapiens	86-91
35300173-13	2022	Hydrogen relieves the oxidative stress in the wound microenvironment via Nrf-2/HO-1 signaling pathway.	Hydrogen	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	73-78
35188163-5	2022	Molecular docking indicated that PVTQPL bound to SGLT1 by forming two hydrogen bonds with Trp257 through the NH2 group and Ile253 through the carbonyl group, ATPase with Phe139 via one arene-H interaction, and GPR40 with Thr39, Ser41, Arg104, Arg2218 and Arg2221 residues through eight hydrogen interactions of its carbonyl groups and hydroxyl groups.	Hydrogen	70-78	solute carrier family 5 member 1	Homo sapiens	49-54
35188163-5	2022	Molecular docking indicated that PVTQPL bound to SGLT1 by forming two hydrogen bonds with Trp257 through the NH2 group and Ile253 through the carbonyl group, ATPase with Phe139 via one arene-H interaction, and GPR40 with Thr39, Ser41, Arg104, Arg2218 and Arg2221 residues through eight hydrogen interactions of its carbonyl groups and hydroxyl groups.	Hydrogen	286-294	solute carrier family 5 member 1	Homo sapiens	49-54
34995654-7	2022	Small molecules are mainly connected to lysozyme through hydrophobic interaction, electrostatic interaction, pi-pi interaction, van der Waals force and hydrogen bond.	Hydrogen	152-160	lysozyme	Homo sapiens	40-48
35188741-7	2022	The results from MD simulations suggest that the hinge region residues Glu1948 and Ala1950 play a significant role in maintaining the intermolecular hydrogen bond interaction with the G2019S LRRK2 protein and inhibitor.	Hydrogen	149-157	leucine rich repeat kinase 2	Homo sapiens	191-196
35188741-8	2022	The strong hinge hydrogen bond with an occupancy rate of more than 95% represents the high activity of LRRK2 inhibitors, and the hydrogen bond interaction with the kinase catalytic loop region could compromise selectivity.	Hydrogen	17-25	leucine rich repeat kinase 2	Homo sapiens	103-108
35188741-8	2022	The strong hinge hydrogen bond with an occupancy rate of more than 95% represents the high activity of LRRK2 inhibitors, and the hydrogen bond interaction with the kinase catalytic loop region could compromise selectivity.	Hydrogen	129-137	leucine rich repeat kinase 2	Homo sapiens	103-108
35188741-9	2022	Further pharmacophore modeling reveals that the high activity LRRK2 inhibitor should have one aromatic ring, one hydrogen bond acceptor, and one hydrogen bond donor.	Hydrogen	113-121	leucine rich repeat kinase 2	Homo sapiens	62-67
35188741-9	2022	Further pharmacophore modeling reveals that the high activity LRRK2 inhibitor should have one aromatic ring, one hydrogen bond acceptor, and one hydrogen bond donor.	Hydrogen	145-153	leucine rich repeat kinase 2	Homo sapiens	62-67
35142315-5	2022	The oxygen atom transfer nitrite reduction of the Cu(II) nitrite complexes leads to the formation of copper(I)-PPh3 and O PPh3 which were confirmed by 1H and 31P NMR.	Hydrogen	151-153	caveolin 1	Homo sapiens	111-115
35142315-5	2022	The oxygen atom transfer nitrite reduction of the Cu(II) nitrite complexes leads to the formation of copper(I)-PPh3 and O PPh3 which were confirmed by 1H and 31P NMR.	Hydrogen	151-153	caveolin 1	Homo sapiens	122-126
35217815-10	2022	In molecular docking analysis we found that trimetazidine directly bound to Akt via a hydrogen bond with Asp292 and a pi-pi bond with Trp80.	Hydrogen	86-94	thymoma viral proto-oncogene 1	Mus musculus	76-79
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Hydrogen	127-135	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-106
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Hydrogen	127-135	nuclear factor, erythroid derived 2, like 2	Mus musculus	186-191
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Hydrogen	127-135	nuclear factor, erythroid derived 2, like 2	Mus musculus	259-263
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Hydrogen	127-135	nuclear factor, erythroid derived 2, like 2	Mus musculus	325-330
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Hydrogen	127-135	heme oxygenase 1	Mus musculus	345-349
35065958-7	2022	Molecular dynamics simulations highlighted two features characterizing the ICL4/NBD1 interface of F508del/R1070W-CFTR: flexibility, with frequent transient formation of interdomain hydrogen bonds, and loosely stacked aromatic sidechains (F1068, R1070W, and F1074, mimicking F1068, F508 and F1074 in wild-type CFTR).	Hydrogen	181-189	CF transmembrane conductance regulator	Homo sapiens	113-117
35065958-8	2022	F508del-CFTR displayed a distorted aromatic stack, with F1068 displaced towards the space vacated by F508, while, in F508del/R1070F-CFTR, which largely retained F508del defects, R1070F could not form hydrogen bonds and the interface was less flexible.	Hydrogen	200-208	CF transmembrane conductance regulator	Homo sapiens	8-12
35065958-8	2022	F508del-CFTR displayed a distorted aromatic stack, with F1068 displaced towards the space vacated by F508, while, in F508del/R1070F-CFTR, which largely retained F508del defects, R1070F could not form hydrogen bonds and the interface was less flexible.	Hydrogen	200-208	CF transmembrane conductance regulator	Homo sapiens	132-136
35148100-5	2022	The interaction between ACE and Fru-His occurred spontaneously mainly through hydrogen bonding, and the process was accompanied by fluorescence quenching and the alteration of the secondary structure of ACE.	Hydrogen	78-86	angiotensin I converting enzyme	Homo sapiens	24-27
35281253-6	2022	Hydrogen-deuterium exchange mass spectrometry (HDX-MS) was used to study the glycosaminoglycan (GAG)-peptide complex and identified V12HHQKL17 as the binding site of GAG at Abeta.	Hydrogen	0-8	amyloid beta precursor protein	Homo sapiens	173-178
35284727-4	2022	In methanol, friction and wear are determined by the hydrogen bonding structure, where friction coefficients relate on saturation effects of sp3-CH, and the wear properties depend on the "collapse effect" that the more the sp3-CH3 and sp3-CH2, the easier the wear out of bulk a-C:H films.	Hydrogen	53-61	Sp3 transcription factor	Homo sapiens	141-144
35284727-4	2022	In methanol, friction and wear are determined by the hydrogen bonding structure, where friction coefficients relate on saturation effects of sp3-CH, and the wear properties depend on the "collapse effect" that the more the sp3-CH3 and sp3-CH2, the easier the wear out of bulk a-C:H films.	Hydrogen	53-61	Sp3 transcription factor	Homo sapiens	223-226
35284727-4	2022	In methanol, friction and wear are determined by the hydrogen bonding structure, where friction coefficients relate on saturation effects of sp3-CH, and the wear properties depend on the "collapse effect" that the more the sp3-CH3 and sp3-CH2, the easier the wear out of bulk a-C:H films.	Hydrogen	53-61	Sp3 transcription factor	Homo sapiens	235-238
35148100-5	2022	The interaction between ACE and Fru-His occurred spontaneously mainly through hydrogen bonding, and the process was accompanied by fluorescence quenching and the alteration of the secondary structure of ACE.	Hydrogen	78-86	angiotensin I converting enzyme	Homo sapiens	203-206
35148100-7	2022	Fru-His was attached to ACE"s S1 active pocket through hydrogen bonds and interacted with zinc ions in active sites.	Hydrogen	55-63	angiotensin I converting enzyme	Homo sapiens	24-27
35090651-3	2022	We herein reported a hydrogen-bond competing fluorescent sensor, BANP, for the detection of dibutyl phthalate (DBP).	Hydrogen	21-29	BTG3 associated nuclear protein	Homo sapiens	65-69
35090651-5	2022	BANP was found to be a turn-on fluorescent probe for DBP in water with a detection limit of 0.13 mug/g; the DBP-water system acts as a hydrogen bond switch to turn on the fluorescence.	Hydrogen	135-143	BTG3 associated nuclear protein	Homo sapiens	0-4
35107451-9	2022	At the interface of the Mpro dimer, we detected three regions that are rich in interfacial water which stabilize the SARS-CoV-2 Mpro dimer by forming hydrogen bonds with two protomers.	Hydrogen	150-158	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	24-28
35192607-2	2022	Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and molecular dynamics (MD) simulations, we generated a comprehensive dynamic allosteric portrait of the C-terminal domains of LRRK2 (LRRK2RCKW).	Hydrogen	6-14	leucine rich repeat kinase 2	Homo sapiens	188-193
35192607-2	2022	Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and molecular dynamics (MD) simulations, we generated a comprehensive dynamic allosteric portrait of the C-terminal domains of LRRK2 (LRRK2RCKW).	Hydrogen	6-14	leucine rich repeat kinase 2	Homo sapiens	195-204
35139301-3	2022	When the benzyl cation ((Me5PACP)Sr(CH2Ph))(BAr4)2 (Ar = C6H3-3,5-Me2 or C6H4-4-nBu) was reacted with dihydrogen or n-octylsilane, dihydride complexes ((Me5PACP)2Sr2(mu-H)2)(BAr4)2 containing a dinuclear core bridged by two hydride ligands were obtained.	Hydrogen	102-112	familial progressive hyperpigmentation 1	Homo sapiens	166-172
35129355-2	2022	Selective C(O)-C bond activation, which employs aminopyridine as a temporary directing group and ethyl vinyl ketone as a hydride acceptor, occurs on the alkyl chain containing a beta-position hydrogen.	Hydrogen	192-200	amyloid beta precursor protein	Homo sapiens	176-182
34978889-6	2022	In the crystallographic analysis of compound-protease (PR) complexes, it was demonstrated that the Tp-THF rings at the P2 moiety of GRL-08513 and GRL-08613 form robust hydrogen-bond interactions with the active-site of HIV-1 PR.	Hydrogen	168-176	nuclear receptor subfamily 3 group C member 1	Homo sapiens	132-135
34978889-6	2022	In the crystallographic analysis of compound-protease (PR) complexes, it was demonstrated that the Tp-THF rings at the P2 moiety of GRL-08513 and GRL-08613 form robust hydrogen-bond interactions with the active-site of HIV-1 PR.	Hydrogen	168-176	nuclear receptor subfamily 3 group C member 1	Homo sapiens	146-149
35107451-9	2022	At the interface of the Mpro dimer, we detected three regions that are rich in interfacial water which stabilize the SARS-CoV-2 Mpro dimer by forming hydrogen bonds with two protomers.	Hydrogen	150-158	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	128-132
35168606-11	2022	Decreased expressions of GPCPD1 and GDE1 in choline metabolism led to an increased GPC levels in the PTX-resistant EOCs, which was observed as an elevated total choline (tCho) on in vivo 1H-MRS.	Hydrogen	187-189	glycerophosphodiester phosphodiesterase 1	Homo sapiens	36-40
35150368-5	2022	The docking study showed that the multiple epitopes on the IgY-scFv interacted with multiple residues on SARS-CoV-2 S1 RBD to form hydrogen bonds.	Hydrogen	131-139	immunglobulin heavy chain variable region	Homo sapiens	63-67
35076199-4	2022	As expected, the fabricated "breathable" wooden electrode exhibits remarkable hydrogen evolution activity in 1.0 M KOH, only requiring a low overpotential of 80 mV to sustain a current density of 10 mA cm-2, and can maintain this current density for 100 h. Further, the spectroscopic characterization and density functional theory (DFT) calculations manifest that the electron interaction between Pd and NiS is beneficial to reduce the water dissociation energy barriers, optimize the adsorption/desorption of H, and ultimately accelerate the catalytic activity.	Hydrogen	78-86	solute carrier family 5 member 5	Homo sapiens	404-407
35224383-10	2022	Furthermore, our studies indicated that the hydrophobic residues and hydrogen bonds from the hinge region (Glu957 and Leu959) of JAK1 played an essential role in stabilizing the inhibitors.	Hydrogen	69-77	Janus kinase 1	Homo sapiens	129-133
35099929-2	2022	The FlexLP ligand encompasses a diphenylphosphine oxide Lewis base and a dimesitylborane Lewis acid attached to a bithiophene scaffold, which can switch between an open unbound Lewis pair and a bound P-O-B Lewis adduct depending on the hydrogen bond-donating (HBD) strength of the solvent.	Hydrogen	236-244	ER membrane protein complex subunit 3	Homo sapiens	200-205
35145184-2	2022	The binding mechanism of CNP for Sn2+ was confirmed by UV-Vis, 1H, and 13C NMR titrations.	Hydrogen	63-65	solute carrier family 38 member 5	Homo sapiens	33-36
35076038-2	2022	NMR spectral evidence indicated that the meso-methyl group and BF2 core of BODIPYs formed C-H N and C-H F-B pseudo-hydrogen bonds with pyridine, respectively.	Hydrogen	115-123	forkhead box G1	Homo sapiens	63-66
35186496-8	2022	Binding energies higher than -102 kcal/mol, RMSD values <0.22 nm, formation of several hydrogen bonds with Mpro, favourable electrostatic contributions, and low radii of gyration were among the estimated factors contributing to the strength of the binding of these three compounds with Mpro.	Hydrogen	87-95	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	107-111
35159611-9	2022	With the addition of CNC, electrostatic interactions, hydrophobic interactions, and hydrogen bonds in the SPI gel network were significantly strengthened.	Hydrogen	84-92	chromogranin A	Homo sapiens	106-109
35014636-5	2022	A new binding mode of CYP2D6 is defined, and two key residues (residue Asp301 and residue Glu216) are discovered working simultaneously to stabilize the DM at the reactive site by forming water bridge hydrogen bonds when CYP2D6 binds DM.	Hydrogen	201-209	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	22-28
35048792-6	2022	The detailed interactions between the analogues of Apigenin and SARS-CoV-2 Mpro inhibitors were determined as hydrogen bonds, electronic bonds and hydrophobic interactions.	Hydrogen	110-118	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	75-79
35049285-2	2022	It was found that the Co(II)-Co(II) bond allows for protonation by (HPPh3)(BF4) resulting in a bridging hydride, (1H)+, with pKa ~ 7.6 in CH2Cl2.	Hydrogen	114-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
35049285-2	2022	It was found that the Co(II)-Co(II) bond allows for protonation by (HPPh3)(BF4) resulting in a bridging hydride, (1H)+, with pKa ~ 7.6 in CH2Cl2.	Hydrogen	114-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-35
35124382-17	2022	Moreover, Tan I interacted with BNIP3 and NIX through hydrogen bond.	Hydrogen	54-62	BCL2 interacting protein 3	Homo sapiens	32-37
35014636-5	2022	A new binding mode of CYP2D6 is defined, and two key residues (residue Asp301 and residue Glu216) are discovered working simultaneously to stabilize the DM at the reactive site by forming water bridge hydrogen bonds when CYP2D6 binds DM.	Hydrogen	201-209	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	221-227
34985081-7	2022	Residue-based free energy decomposition reveals that the inhibitor-Mpro interaction networks involving hydrogen bonding interactions and hydrophobic interactions provide significant information for the design of potent inhibitors against Mpro.	Hydrogen	103-111	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	67-71
34991150-5	2022	The structure of the Co(II) complexes was investigated using 1H NMR spectroscopy and computational methods.	Hydrogen	61-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
34991150-10	2022	The presence of highly shifted 1H NMR signals due to the amide protons in slow exchange with bulk water results in sizeable CEST signals, which are observed at +67 and +15 ppm for the Co(II) complex with 3,9-PC2AMH and +42 and +7 ppm for the Ni(II) analogue at 25  C.	Hydrogen	31-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-190
34994203-5	2022	Further computational calculations demonstrated the adjustable IPA position in STR1 upon the binding of secologanin, and Tyr151-OH facilitates the productive PSR binding mode via an advantageous hydrogen-bond network.	Hydrogen	195-203	matrix metallopeptidase 3	Homo sapiens	79-83
34951620-1	2022	The alpha/beta-peptide 11/9-helix and the beta-peptide 12/10-helix belong to "mixed" helices, in which two types of hydrogen bonds with opposite directionality alternate along the helical axis.	Hydrogen	116-124	amyloid beta precursor protein	Homo sapiens	4-14
35164019-8	2022	Gene expression of GST-P, PCNA, PDK, and PIK3CA decreased in the DMBA group treated with alpha-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one, whereas PIK3R1 and BAX increased in the DMBA group treated with alpha-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one.	Hydrogen	322-324	glutathione S-transferase pi 1	Rattus norvegicus	19-24
34985081-7	2022	Residue-based free energy decomposition reveals that the inhibitor-Mpro interaction networks involving hydrogen bonding interactions and hydrophobic interactions provide significant information for the design of potent inhibitors against Mpro.	Hydrogen	103-111	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	238-242
35013561-6	2022	The epithelial sodium-hydrogen exchanger, NHE1, is a ubiquitous plasma membrane protein tasked with the maintenance of cytoplasmic pH at neutrality.	Hydrogen	22-30	solute carrier family 9 member A1	Homo sapiens	42-46
34978431-2	2022	To understand how these mutations so dramatically alter one activity over the other, we compared the backbone dynamics of wild type thrombin to those of the W215A/E217A mutant thrombin by hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS).	Hydrogen	188-196	coagulation factor II, thrombin	Homo sapiens	132-140
34978431-2	2022	To understand how these mutations so dramatically alter one activity over the other, we compared the backbone dynamics of wild type thrombin to those of the W215A/E217A mutant thrombin by hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS).	Hydrogen	188-196	coagulation factor II, thrombin	Homo sapiens	176-184
35310501-6	2022	Such hydrogen bonding interactions are also present with the C9 and C10 axles resulting in a compression of the alkyl chain with gauche conformations in the solid state.	Hydrogen	5-13	homeobox C10	Homo sapiens	68-71
35111810-3	2021	In addition, molecular docking studies were achieved, which showed that all the newly synthesized compounds are interacting with the active site region of the target enzymes, the targets UDP-N-acetylmuramatel-alanine ligase (MurC), and human lanosterol14alpha-demethylase, through hydrogen bonds and pi-stacked interactions.	Hydrogen	281-289	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	242-271
35053900-6	2022	The binding constant between baicalein and AChE was an order of magnitude of 104 L mol-1, and hydrogen bonding and hydrophobic interaction were the major forces for forming the baicalein-AChE complex.	Hydrogen	94-102	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-47
35053900-6	2022	The binding constant between baicalein and AChE was an order of magnitude of 104 L mol-1, and hydrogen bonding and hydrophobic interaction were the major forces for forming the baicalein-AChE complex.	Hydrogen	94-102	acetylcholinesterase (Cartwright blood group)	Homo sapiens	187-191
35114918-15	2022	Further, molecular simulations indicated that hypericin could strongly interact with ASP98, PHE307, and ARG355 to form four hydrogen bonds within hCE2.	Hydrogen	124-132	carboxylesterase 2	Homo sapiens	146-150
34672031-2	2022	This reaction follows the mechanism of hydrogen atom transfer (HAT) and is facilitated by the Ob .- radical center.	Hydrogen	39-47	cadherin 11	Homo sapiens	94-96
35069453-10	2021	In silico docking, the method utilized indicated that more hydrogen bonds formation contributed to the stronger inhibition of 3,5-DBP than 3-BP.	Hydrogen	59-67	D-box binding PAR bZIP transcription factor	Homo sapiens	130-133
35079241-7	2022	The results indicate that GSH is the leading inhibitor model among the other tested vitamins in the active site of Mpro with a RR value of 94% and MEV of - 5.5 kcal/mol, its RMSD, RMSF, Rg, and hydrogen bonds show stability with Mpro.	Hydrogen	194-202	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	115-119
34653813-0	2022	Computer analysis of the relation between hydrogen bond stability in SOD1 mutants and the survival time of amyotrophic lateral sclerosis patients.	Hydrogen	42-50	superoxide dismutase 1	Homo sapiens	69-73
34653813-4	2022	RESULTS: The stability of hydrogen bonds in 72 mutants of the SOD1 protein was calculated.	Hydrogen	26-34	superoxide dismutase 1	Homo sapiens	62-66
35059257-0	2022	Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial.	Hydrogen	13-21	insulin	Homo sapiens	85-92
35129191-4	2022	We demonstrated that TANVBC71 was absorbed faster in high amounts by cancer cells than nanovesicles owing to its high affinity for the epidermal growth factor receptor and extracellular matrix components that are driven by van der Waals attraction as well as hydrogen bonding and hydrophobic interactions in a complex manner.	Hydrogen	259-267	epidermal growth factor receptor	Homo sapiens	135-167
35264206-4	2022	The SPc could assemble with dsRNA spontaneously through electrostatic force, hydrogen bond and van der Waals force.	Hydrogen	77-85	surfactant protein C	Homo sapiens	4-7
35178955-11	2022	Molecular docking showed that PPI bound to the extracellular domain of EGFR and formed hydrogen bond with Gln366 residue.	Hydrogen	87-95	epidermal growth factor receptor	Homo sapiens	71-75
2561421-10	1989	Only one transannular hydrogen bond, between Ist1 NH and Leu3 carbonyl, stabilizes the conformation of the depsipeptide, which has an irregular non-planar configuration.	Hydrogen	22-30	IST1 factor associated with ESCRT-III	Homo sapiens	45-49
2561421-11	1989	The small temperature coefficients (less than 2.0 x 10(-3) ppm/degrees C) for the NHs of Ist1 and Leu3 are consistent with their involvement in these hydrogen bonding interactions.	Hydrogen	150-158	IST1 factor associated with ESCRT-III	Homo sapiens	89-93
2615366-1	1989	The stereospecificity of hydrogen transfer between steroid (17-hydroxyprogesterone) and both natural cofactors by bovine testicular 20 alpha-hydroxysteroid dehydrogenase (20 alpha-HSD) has been determined.	Hydrogen	25-33	placental and ovary 20alpha hydroxysteroid dehydrogenase protein	Bos taurus	171-183
2550705-2	1989	EIAs using beta-galactosidase linked to P11-HS, 11 alpha-hydroxyprogesterone 11-hemimaleate (P11-HM), 11 alpha-hydroxyprogesterone 11-glucuronide (P11-Glu) or progesterone 3-(o-carboxymethyl) oxime (P3-CMO) were compared.	Hydrogen	43-46	galactosidase beta 1	Homo sapiens	11-29
2596609-5	1989	In vitamin D-deficient rat animals, G6PD activity in the middle part of the villus was approximately 60% lower than in normal animals [10.05 +/- 0.35 vs. 3.95 +/- 0.26 (means +/- SE) A585.min-1.micron-3 X 10(5), P less than 0.001] with reduced NADPH utilization via the H2 pathway (8.39 +/- 0.49 vs. 2.73 +/- 0.43 A585.min-1.micron-3 X 10(5), P less than 0.001) but not the H1 pathway (1.65 +/- 0.17 vs. 1.22 +/- 0.19 A585.min-1.micron-3 X 10(5), P = NS).	Hydrogen	270-272	glucose-6-phosphate dehydrogenase	Rattus norvegicus	36-40
2666135-4	1989	Comparison of the 500-MHz 1H-NMR spectra of the mutant proteins with that of wild-type phosphoglycerate kinase shows that the overall fold of the mutants remains essentially unaltered from that of the native enzyme.	Hydrogen	26-28	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	87-110
2615366-10	1989	The results indicate that bovine testicular 20 alpha-HSD catalyzes transfer of the 4A-hydrogen from the dihydronicotinamide moiety of the reduced cofactor.	Hydrogen	86-94	placental and ovary 20alpha hydroxysteroid dehydrogenase protein	Bos taurus	44-56
2819050-0	1989	1H NMR sequential resonance assignments, secondary structure, and global fold in solution of the major (trans-Pro43) form of bovine calbindin D9k.	Hydrogen	0-2	S100 calcium binding protein G	Bos taurus	132-145
2775745-0	1989	1H NMR studies of porcine calbindin D9k in solution: sequential resonance assignment, secondary structure, and global fold.	Hydrogen	0-2	S100 calcium binding protein G	Bos taurus	26-39
2775745-1	1989	The 1H nuclear magnetic resonance (NMR) spectrum of Ca2+-saturated porcine calbindin D9k (78 amino acids, Mr 8800) has been assigned.	Hydrogen	4-6	S100 calcium binding protein G	Bos taurus	75-88
2556483-3	1989	The rCBF in brain and/or tumour tissues was sequentially measured by inhalation hydrogen clearance method.	Hydrogen	80-88	CCAAT/enhancer binding protein zeta	Rattus norvegicus	4-8
2592252-4	1989	In periportal and pericentral areas, Vmax values for G6PDH activity were 4.48 +/- 1.03 mumol H2 cm-3 min-1) and 3.47 +/- 0.78 mumol H2 cm-3 min-1), respectively.	Hydrogen	93-95	glucose-6-phosphate dehydrogenase	Rattus norvegicus	53-58
2819050-1	1989	A wide range of two-dimensional 1H NMR experiments have been used to completely assign the 500-MHz 1H NMR spectrum of recombinant Ca2+-saturated bovine calbindin D9k (76 amino acids, Mr = 8500).	Hydrogen	32-34	S100 calcium binding protein G	Bos taurus	152-165
2819050-1	1989	A wide range of two-dimensional 1H NMR experiments have been used to completely assign the 500-MHz 1H NMR spectrum of recombinant Ca2+-saturated bovine calbindin D9k (76 amino acids, Mr = 8500).	Hydrogen	99-101	S100 calcium binding protein G	Bos taurus	152-165
2470644-4	1989	The nucleotide sequence of H1 RNA, which shows little homology to the known sequences of its analogs from prokaryotes and yeast, can be drawn as a two-dimensional, hydrogen-bonded structure that resembles similar structures proposed for the RNA subunit of RNase P from these other sources.	Hydrogen	164-172	ribonuclease P RNA component H1	Homo sapiens	27-33
2792084-6	1989	A network of seven hydrogen bonds connects oxygen atoms O-3, O-4, O-5 and O-6 of the mannoside to residues Asn14, Leu99, Tyr100, Asp208 and Arg228.	Hydrogen	19-27	immunoglobulin kappa variable 1D-37 (non-functional)	Homo sapiens	61-77
2517949-1	1989	Transformation of murine NIH3T3 fibroblasts with retroviral vectors carrying the mos, myc and the Ha-ras oncogene, respectively, was associated with a strong reduction of H2 antigen expression in the cell membrane.	Hydrogen	171-173	myelocytomatosis oncogene	Mus musculus	86-89
2753306-8	1989	The determination of t1/2 E seems to be a good approach to the duration of action of H2-antagonists.	Hydrogen	85-87	interleukin 1 receptor like 1	Homo sapiens	21-27
2723680-7	1989	The sequential measurements of regional cerebral blood flow (rCBF) in the bilateral hippocampus by the hydrogen clearance method disclosed a steady decrease in rCBF after the occlusion, 51% of the pre-occlusion state at 10 min, 35% at 25 min and 32% at 40 min.	Hydrogen	103-111	CCAAT/enhancer binding protein zeta	Rattus norvegicus	61-65
2723680-7	1989	The sequential measurements of regional cerebral blood flow (rCBF) in the bilateral hippocampus by the hydrogen clearance method disclosed a steady decrease in rCBF after the occlusion, 51% of the pre-occlusion state at 10 min, 35% at 25 min and 32% at 40 min.	Hydrogen	103-111	CCAAT/enhancer binding protein zeta	Rattus norvegicus	160-164
2785403-1	1989	The 1H NMR spectrum of human transforming growth factor alpha (TGF-alpha) was analyzed almost completely by the sequential assignment method using two-dimensional NMR techniques.	Hydrogen	4-6	transforming growth factor alpha	Homo sapiens	63-72
2713333-1	1989	The 1H NMR spectrum of human transforming growth factor alpha (hTGF-alpha) has been completely assigned, and secondary structural elements have been identified as a preliminary step in determining the structure of this protein by distance geometry methods.	Hydrogen	4-6	transforming growth factor alpha	Homo sapiens	63-73
2719924-11	1989	1H NMR experiments indicate that citrate synthase catalyzes the exchange of the alpha-hydrogens of Ac(= S)CoA with turnover numbers of 0.13 and 0.54 s-1 at pD 7.9 and 7.2, respectively.	Hydrogen	0-2	citrate synthase	Homo sapiens	33-49
2647858-3	1989	In the presence of CsA, photolysis of BBa results in hydrogen abstraction and random insertion into the cyclosporine molecule, generating a population of CsA with carboxyl groups at various positions.	Hydrogen	53-61	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	19-22
2719924-11	1989	1H NMR experiments indicate that citrate synthase catalyzes the exchange of the alpha-hydrogens of Ac(= S)CoA with turnover numbers of 0.13 and 0.54 s-1 at pD 7.9 and 7.2, respectively.	Hydrogen	86-95	citrate synthase	Homo sapiens	33-49
2464057-13	1989	These data provide evidence for involvement of calmodulin in the acid secretory process and suggest that the pursuit of selective calmodulin antagonists such as CGS-9343B may prove useful for understanding the regulation of the hydrogen ion secretory process.	Hydrogen	228-236	calmodulin 1	Rattus norvegicus	130-140
2646637-3	1989	This report describes sequence-specific 1H-NMR resonance assignments for recombinant human TGF alpha (hTGF alpha).	Hydrogen	40-42	transforming growth factor alpha	Homo sapiens	91-112
2642135-5	1989	Regional cerebral blood flow (rCBF) in the ectosylvian region was measured by a hydrogen clearance method.	Hydrogen	80-88	CCAAT/enhancer binding protein zeta	Rattus norvegicus	30-34
2910900-3	1989	With these methods, it was observed that a reduction in blood flow occurred shortly after insertion of an electrode into the striatum for hydrogen clearance measurement, affecting rCBF throughout the impaled hemisphere.	Hydrogen	138-146	CCAAT/enhancer binding protein zeta	Rattus norvegicus	180-184
2928298-2	1989	A technique for proton labelling of selected amino acids in deuterated calbindin D9K, heterologously expressed in E. coli, was developed in order to simplify and obtain higher resolution in 1H-NMR spectra.	Hydrogen	190-192	S100 calcium binding protein G	Bos taurus	71-84
2851291-4	1988	The nucleotide sequence of H1, R1 and M1 reveals the possibility of the formation of hairpin structures, stabilized by hydrogen bond formation, between three or four consecutive bases.	Hydrogen	119-127	histocompatibility 1	Mus musculus	27-40
2910900-7	1989	These results clearly demonstrate that reduction of CBF subsequent to electrode placement can account for the low values frequently obtained with the hydrogen clearance method in small animals.	Hydrogen	150-158	CCAAT/enhancer binding protein zeta	Rattus norvegicus	52-55
2618663-1	1989	1H and 13C NMR spectra of d,l- and meso-HM-PAO in different solvents were studied at different resonance frequencies.	Hydrogen	0-2	spermine oxidase	Homo sapiens	43-46
2913308-9	1989	The interaction of the p-hydroxyl group of the tyramine moiety may involve hydrogen bonding since the corresponding methyl ethers show a greatly reduced affinity for the active site of PNMT (Ki = 34 and 389 microM for methoxy analogues 28 and 35, compared to Ki = 4.7 and 111 microM for the corresponding phenolic analogues 14 and 23).	Hydrogen	75-83	phenylethanolamine N-methyltransferase	Homo sapiens	185-189
2907107-2	1988	The model was used to investigate the patterns of changes of regional cerebral blood flow (rCBF) for up to 16 h following MCA occlusion by the hydrogen clearance technique and to explore the correlation among changes of rCBF, neurological deficits, and pathological changes.	Hydrogen	143-151	CCAAT/enhancer binding protein zeta	Rattus norvegicus	91-95
3171590-0	1988	Intracellular pH, lactate, and energy metabolism in neonatal brain during partial ischemia measured in vivo by 31P and 1H nuclear magnetic resonance spectroscopy.	Hydrogen	119-121	glucose-6-phosphate isomerase	Homo sapiens	14-16
3241783-3	1988	The calculated h2 for GH was moderate.	Hydrogen	15-17	growth hormone	Gallus gallus	22-24
3138908-3	1988	H2 mean excretion was 78.3 +/- 5.49 ppm after administration of intact whole milk 500 ml (test A), 43.5 +/- 4.99 ppm when lactase 2000 U was added to milk 500 ml immediately before administration (test B); 36.7 +/- 5.01 ppm when milk 500 ml was incubated for 12 h with lactase 1000 U (test C), and 29.7 +/- 4.35 ppm when the incubation was prolonged for 24 h (test D).	Hydrogen	0-2	lactase	Homo sapiens	122-129
3416869-7	1988	The C-2 hydroxyl group of the sugar is also a hydrogen-bond donor to APA.	Hydrogen	46-54	glutamyl aminopeptidase	Homo sapiens	69-72
3416869-9	1988	The C-6 hydroxyl group of the sugar is weakly hydrogen bonded with neutral groups of EIL, EAL, and APA.	Hydrogen	46-54	complement C6	Homo sapiens	4-7
3416869-9	1988	The C-6 hydroxyl group of the sugar is weakly hydrogen bonded with neutral groups of EIL, EAL, and APA.	Hydrogen	46-54	glutamyl aminopeptidase	Homo sapiens	99-102
3072564-8	1988	In the crystal structure of insulin a hydrogen bond bridges the alpha-nitrogen of A21 with the backbone carbonyl of B23 glycine.	Hydrogen	38-46	insulin	Sus scrofa	28-35
3214155-9	1988	This was attributed to release of sulfate from the mucin which enabled SRB to outcompete methanogenic bacteria for H2.	Hydrogen	115-117	LOC100508689	Homo sapiens	51-56
2451933-0	1988	Calculation of NH...pi hydrogen bond energies in basic pancreatic trypsin inhibitor.	Hydrogen	23-31	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	66-83
3416869-11	1988	The C-6 hydroxyl groups is a hydrogen-bond acceptor for EIL and EAL, a hydrogen-bond donor for APA and BSL-I, and appears not to be involved in binding to RCA-I.	Hydrogen	29-37	complement C6	Homo sapiens	4-7
3416869-11	1988	The C-6 hydroxyl groups is a hydrogen-bond acceptor for EIL and EAL, a hydrogen-bond donor for APA and BSL-I, and appears not to be involved in binding to RCA-I.	Hydrogen	71-79	complement C6	Homo sapiens	4-7
3323092-2	1987	Hydrogen bonding involving peptide bonds of the backbone of the insulin molecule may play an important role in insulin-receptor interaction.	Hydrogen	0-8	insulin receptor	Rattus norvegicus	111-127
3214155-10	1988	SRB stimulated by mucin were acetate-utilizing Desulfobacter spp., lactate- and H2-utilizing Desulfovibrio spp., and propionate-utilizing Desulfobulbus spp.	Hydrogen	80-82	LOC100508689	Homo sapiens	18-23
3653391-1	1987	The hyperfine shifted resonances arising from all four individual haem carbons of the paramagnetic low-spin met-cyano complex of sperm whale myoglobin have been clearly identified and assigned for the first time with the aid of 1H-13C heteronuclear chemical shift correlated spectroscopy.	Hydrogen	228-230	myoglobin	Physeter catodon	141-150
2832166-0	1988	15N- and 1H-NMR investigations of the active-site amino acids in semisynthetic RNase S" and RNase A.	Hydrogen	9-11	ribonuclease A family member 1, pancreatic	Homo sapiens	92-99
3232904-1	1988	In a double-blind study using the hydrogen breath-excretion test to identify lactase status, we found 45% of absorbers in a group of 64 patients with senile cataracts compared with 71% of absorbers in the control group.	Hydrogen	34-42	lactase	Homo sapiens	77-84
2832166-10	1988	For comparison with the 15N-NMR titration curves of His-12 in RNase S" the 1H-NMR titration curves of RNase A were also recorded.	Hydrogen	75-77	ribonuclease A family member 1, pancreatic	Homo sapiens	102-109
3673112-5	1987	An isomer of TR-2, a minor component of the bile of sheep given verruculogen, has been defined by 1H-n.m.r.	Hydrogen	98-100	nuclear receptor subfamily 2, group C, member 1	Rattus norvegicus	13-17
2976601-8	1988	With the aid of NMR spectrometry, the two replaced hydrogen atoms are found to be incorporated into the C-2 and C-6 positions of the bicyclo-diyne-ene ring of NCS-chrom and are derived neither from borodeuteride nor from the hydroxyl functions of the solvents.	Hydrogen	51-59	complement C6	Homo sapiens	112-115
3571255-2	1987	As deduced from its 1H NMR spectrum, oncomodulin"s solution conformation is very similar to the tertiary structure of other single domain 2-site calcium-binding proteins of the troponin C class.	Hydrogen	20-22	oncomodulin	Homo sapiens	37-48
3571255-5	1987	Lineshape analyses of several 1H NMR resonances generated by the Lu(III) titration of Ca2-oncomodulin indicated that Ca(II)----Ln(III) exchange at the CD site was 15-20 s-1, approximately 100 times faster than exchange at the CD site of parvalbumins.	Hydrogen	30-32	oncomodulin	Homo sapiens	90-101
3356609-1	1988	The binding of the antibiotic kirromycin (mocimycin) to its target protein, bacterial elongation factor Tu (EF-Tu), has been studied by 1H NMR spectroscopy using deuterated protein.	Hydrogen	136-138	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	86-106
3356609-1	1988	The binding of the antibiotic kirromycin (mocimycin) to its target protein, bacterial elongation factor Tu (EF-Tu), has been studied by 1H NMR spectroscopy using deuterated protein.	Hydrogen	136-138	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	108-113
3167026-8	1988	A search for the amino acid residues in the primary sequence of trypanothione reductase functionally active in binding/catalysis in human erythrocyte glutathione reductase shows that only the two arginine residues (Arg-37 and Arg-347), shown by X-ray crystallographic data to hydrogen bond to the GS1 glutathione glycyl carboxylate, are absent.	Hydrogen	276-284	glutathione-disulfide reductase	Homo sapiens	150-171
3248674-7	1988	Enzymes in this category are mitochondrial MAO from different tissues; (b) The second type of deamination involves the abstraction of pro-S hydrogen.	Hydrogen	140-148	monoamine oxidase A	Rattus norvegicus	43-46
3479798-6	1987	These base pairs have a high positive propeller twist so that in the major groove the adenine amino group is located intermediate between the carbonyl O-4 groups of two adjacent thymines of the opposite strand, making bifurcated hydrogen bonds to the two thymine residues.	Hydrogen	229-237	immunoglobulin kappa variable 1D-37 (non-functional)	Homo sapiens	151-154
2883568-0	1987	On the structure-activity relationship of histamine H2-receptor antagonists based on the X-ray crystal structures and 1H-NMR spectra of amidine derivatives.	Hydrogen	118-120	histamine receptor H2	Homo sapiens	42-63
3197695-2	1988	Measurement of regional cerebral blood flow (rCBF) in the limbic structure and cerebral cortex was performed by means of the hydrogen clearance method.	Hydrogen	125-133	CCAAT/enhancer binding protein zeta	Rattus norvegicus	45-49
3822822-7	1987	Results from high resolution mass spectrometry and 1H NMR indicate that the new photoproduct comprises a mixture of two stereoisomers whose formation involves covalent coupling of the adenine bases in d(ApA) and concomitant incorporation of the elements of one molecule of water.	Hydrogen	51-53	glutamyl aminopeptidase	Homo sapiens	203-206
3118327-4	1987	It was established that pretreatment of milk with beta-galactosidase has a beneficial effect in adult lactose maldigestion, since it stops dyspeptic complaints and diarrhoea due to milk, it reduces the H2 content of expired air increases blood glucose concentration.	Hydrogen	202-204	galactosidase beta 1	Homo sapiens	50-68
3801398-8	1986	Interesting features of the structure include possible intra- and interchain sugar-phosphate attractions and a hydration tunnel inside the minor groove capable of accommodating three types of water molecules that aid in helix stabilization via hydrogen bonding.	Hydrogen	244-252	activation induced cytidine deaminase	Homo sapiens	213-216
3741842-5	1986	These data may be utilized as an aid in the elucidation of the nature of hydrogen bonding between mismatched base pairs in DNA oligomers containing cytosine or adenine residues.	Hydrogen	73-81	activation induced cytidine deaminase	Homo sapiens	33-36
3722173-7	1986	Examination of the hydrogen bonding patterns in the calcium-binding loops of ICaBP and the related protein, parvalbumin, reveals several conserved hydrogen bonds which are evidently important for loop stabilization.	Hydrogen	19-27	parvalbumin	Bos taurus	108-119
3699165-3	1986	Here we report their binding to Pr3+ and demonstrate, by 1H NMR, the peptide-mediated transport of Pr3+ across dimyristoylphosphatidylcholine unilamellar vesicles via a 2:1 ion-sandwich complex.	Hydrogen	57-59	proteinase 3	Homo sapiens	99-102
3485542-3	1986	In contrast, Vmax,app values were substantially decreased by substitution of deuterium for hydrogen on the tetrahydropyridinium ring, especially at C-6.	Hydrogen	91-99	complement C6	Homo sapiens	148-151
3123631-8	1987	In conclusion, lactase activity in Chinese children decreases gradually after 3 years of age, a finding that correlates well with the results of the breath hydrogen test.	Hydrogen	156-164	lactase	Homo sapiens	15-22
3590284-8	1987	The finding that eta rose with HT more steeply when the HS:HT ratio rather than HS was held constant suggested that the absolute level of HS may be more useful than the HS:HT ratio as a guide for a transfusion regimen.	Hydrogen	56-58	endothelin receptor type A	Homo sapiens	17-20
3690723-4	1987	The implications are that the binding sites of cytochromes P-448 contain a number of hydrophobic aromatic amino acid residues orientated so as to allow occupation by similar substrates containing co-planar aromatic rings, whereas those of the phenobarbital-induced cytochromes P-450 contain hydrophilic amino acid residues capable of hydrogen bonding to greater than C = O moieties and at least one leucine or valine residue, as these contain the complementary isopropyl function.	Hydrogen	334-342	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	277-282
3031314-5	1986	Measurements of the 1H spin-lattice (R1) and spin-spin (R2) relaxation rates of the exchangeable thymine (Tim) and guanine (Gim) imino protons have been used to probe the internal dynamics of the B and Z-forms of poly[d(A-br5C).d(G-T)] and the mechanism of the B-Z transition.	Hydrogen	20-22	Rho guanine nucleotide exchange factor 5	Homo sapiens	106-109
3098249-7	1986	Permeability studies revealed that preincubation with 2.0 X 10(-5) M aspirin increased the permeability of mucin to hydrogen ion by 10%, while an 18% increase was obtained with 4.0 X 10(-5) M aspirin.	Hydrogen	116-124	LOC100508689	Homo sapiens	107-112
3090211-3	1986	A significant increase in regional cerebral blood flow (rCBF), measured by the hydrogen clearance method, was demonstrated in the CA-depleted cortex under normocapnia as compared with rCBF in the control cortex (CA-depleted cortex 47.0 +/- 2.8 ml/100 gm/min; control cortex 38.5 +/- 3.5 ml/100 gm/min; p less than 0.005).	Hydrogen	79-87	CCAAT/enhancer binding protein zeta	Rattus norvegicus	56-60
3092418-1	1986	The adult lactase phenotype, lactose absorber or malabsorber, was determined using the lactose tolerance test with breath hydrogen assay in a group of young, healthy, male Turks.	Hydrogen	122-130	lactase-phlorizin hydrolase	Meleagris gallopavo	10-17
3722173-7	1986	Examination of the hydrogen bonding patterns in the calcium-binding loops of ICaBP and the related protein, parvalbumin, reveals several conserved hydrogen bonds which are evidently important for loop stabilization.	Hydrogen	147-155	parvalbumin	Bos taurus	108-119
2874026-7	1986	We observed an increase in the permeability of thylakoid membrane to hydrogen ions that correlated with indications of coupling factor activity: the onset of ATP synthesis, the release of tightly bound ADP and, in dithiothreitol treated membranes, the initiation of ATPase activity.	Hydrogen	69-77	dynein axonemal heavy chain 8	Homo sapiens	266-272
3720670-8	1986	We postulate on the basis of these results that a hydrogen gradient across the membrane either of the rough endoplasmic reticulum or the transitional vesicle is coupled to the rough endoplasmic reticulum to Golgi translocation step such that dissipation of the proton gradient blocks the secretion of hCG.	Hydrogen	50-58	chorionic gonadotropin subunit beta 5	Homo sapiens	301-304
3718973-9	1986	These data indicate that the steroid-binding site of hSBP and rSBP is a nonpolar cavity containing a proton acceptor that participates in a specific interaction, possibly a hydrogen bond, with the 3"-hydroxyl group of the bound steroid.	Hydrogen	173-181	selenium binding protein 1	Homo sapiens	53-57
3749868-0	1986	1H NMR investigation of the binding of methyl-beta-D-galactoses with sialic acid residues on hepatic binding protein--the effect of divalent calcium ions.	Hydrogen	0-2	heme binding protein 1	Homo sapiens	93-116
3929623-8	1985	Higher intravenous infusion rates of TRH (1 and 2 mg X kg-1h-1) prevented the postnephrectomy natriuresis without affecting the kaliuresis.	Hydrogen	58-60	thyrotropin releasing hormone	Rattus norvegicus	37-40
2863229-7	1985	An equilibrium involving two gamma turn conformations stabilized respectively by Cys2-D-Trp4 and Phe3-Lys5 hydrogen bonds, is responsible for the large upfield shift observed for the Lys5 gamma protons and is compatible with the measured JNH-C alpha H coupling constants.	Hydrogen	107-115	dihydrolipoamide dehydrogenase	Homo sapiens	97-101
3981537-9	1985	The higher activity of the C-6 methyl and methoxyl analogues (R)-15 and (R)-22 relative to hydrogen-substituted (R)-19 indicates that C-6 alkyl substitution enhances analgesic potency.	Hydrogen	91-99	complement C6	Homo sapiens	134-137
2580699-1	1985	The conductance observed for single proton channels formed by proteolipids of ATPase (Schindler and Nelson 1982) is rationalized in terms of a hydrogen bonded network model.	Hydrogen	143-151	dynein axonemal heavy chain 8	Homo sapiens	78-84
6510415-4	1984	360-MHz 1H nuclear magnetic resonance spectroscopy in (2H)dimethylsulfoxide of deuterium-exchanged native B-III and B-IV identified all carbohydrate components, their sites of attachment, the anomeric nature of their glycosidic linkages and the sequential arrangement within the oligosaccharide chain.	Hydrogen	8-10	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	106-111
6519584-4	1984	rCBF of the cortex (suprasylvian gyrus) and the internal capsule was monitored by the hydrogen clearance method.	Hydrogen	86-94	CCAAT/enhancer binding protein zeta	Rattus norvegicus	0-4
6466614-9	1984	In good agreement with this, it was found by photochemically induced dynamic nuclear polarization 1H NMR that aromatic resonances of Trp-3 and Tyr-69 are affected by transamination.	Hydrogen	98-100	transient receptor potential cation channel subfamily C member 3	Bos taurus	133-138
6145771-0	1984	The effect of intramolecular hydrogen bonding on the thermodynamics of partitioning of an isomer of the histamine H2-receptor antagonist metiamide.	Hydrogen	29-37	histamine receptor H2	Homo sapiens	104-125
6712956-1	1984	The redox potential-pH characteristics of the enzyme L-amino-acid oxidase (L-amino-acid: oxygen oxidoreductase (deaminating), EC 1.4.3.2) have been measured in the pH range 6.2 to 8.3 at 4 degrees C. All potentials are reported versus the standard hydrogen electrode.	Hydrogen	248-256	interleukin 4 induced 1	Homo sapiens	53-73
6697240-0	1984	Pathways of hydrogen utilization from NADPH generated by glucose-6-phosphate dehydrogenase in circumventricular organs and the hypothalamo-neurohypophysial system: a cytochemical study.	Hydrogen	12-20	glucose-6-phosphate dehydrogenase	Rattus norvegicus	57-90
6697240-1	1984	Cytochemistry was used to examine the distribution of two pathways of utilization of hydrogen (Type I and Type II H) generated by glucose-6-phosphate dehydrogenase (G6PD) in circumventricular organs (CVOs) and the hypothalamo-neurohypophysial system in cryostat sections of rat brain.	Hydrogen	85-93	glucose-6-phosphate dehydrogenase	Rattus norvegicus	130-163
6697240-1	1984	Cytochemistry was used to examine the distribution of two pathways of utilization of hydrogen (Type I and Type II H) generated by glucose-6-phosphate dehydrogenase (G6PD) in circumventricular organs (CVOs) and the hypothalamo-neurohypophysial system in cryostat sections of rat brain.	Hydrogen	85-93	glucose-6-phosphate dehydrogenase	Rattus norvegicus	165-169
6706914-5	1984	These results indicate that the introduced deuterium (or hydrogen) is in the pro-R position at C-1 of putrescine, and consequently the ornithine decarboxylase reaction proceeds with retention of configuration.	Hydrogen	57-65	ornithine decarboxylase 1	Homo sapiens	135-158
6317075-1	1983	Four exchangeable protons with large hyperfine shifts are assigned in the heme pocket of sperm whale met-cyano myoglobin reconstituted with heme possessing acetyl groups, ethyl groups, bromines, and hydrogens at the 2,4 position, using both relaxation and chemical-shift data.	Hydrogen	199-208	myoglobin	Physeter catodon	111-120
3085481-1	1986	The adult lactase phenotype, lactose absorber or malabsorber, was determined using the lactose tolerance test with breath hydrogen assay in a group of Tuareg, a traditionally nomadic pastoralist population in the central Sahara.	Hydrogen	122-130	lactase	Homo sapiens	10-17
3416320-7	1988	The conformations in aqueous solution were similar, whereas crystalline galabiose or methyl beta-D-galabioside in solution in methyl sulfoxide adopted different conformations that showed intramolecular hydrogen bonds (O-5".	Hydrogen	202-210	immunoglobulin kappa variable 2D-36 (pseudogene)	Homo sapiens	218-221
3008818-0	1986	1H NMR investigation of cytochrome cd1: complexes with electron-donor proteins.	Hydrogen	0-2	CD1c molecule	Homo sapiens	35-38
3487502-5	1986	This suggests that although the N-glycolyl (-CH2OH) group of HD3 is the most important determinant for manifestation of HD antigenicity, it is likely that the antibody recognizes both the N-glycolyl and carboxyl groups together when they form a hydrogen bond (-CH2OH---OOC-), aided by their possible proximity, and that substitution of either group therefore reduces the reaction of HD3 with HD antibody dramatically.	Hydrogen	245-253	histone deacetylase 3	Homo sapiens	61-64
6175644-1	1982	Resonances of 1H NMR spectra (360 MHz) due to several individual substituents of myelin basic protein reconstituted into phospholipid micelles have been resolved and assigned.	Hydrogen	14-16	myelin basic protein	Homo sapiens	81-101
7080129-0	1982	Measurement of rCBF by H2 clearance: theoretical analysis of diffusion effects.	Hydrogen	23-25	CCAAT/enhancer binding protein zeta	Rattus norvegicus	15-19
3289613-4	1988	1H NMR spectra of enzyme/D-gluco-octenitol digests in D2O showed that the alpha-anomer of [2-2H]-D-gluco-octulose was exclusively produced by each alpha-glucosidase, whereas the beta-anomer was formed by action of the trehalase.	Hydrogen	0-2	trehalase	Homo sapiens	218-227
3754862-8	1986	1H NMR studies suggested that the pale colored species was a complex of fully reduced adrenodoxin reductase and NADPH, and that the semiquinone also bound 1 mol of the pyridine nucleotide per mol of the reductase.	Hydrogen	0-2	ferredoxin reductase	Homo sapiens	86-107
2895992-9	1988	The drugs appeared to affect the hydrogen donor system of the reductase complex, since the activity of the ribonucleotide reductase enzyme itself was not affected but both thioredoxin and glutaredoxin were markedly inactivated by the sesquiterpene lactones.	Hydrogen	33-41	glutaredoxin	Homo sapiens	188-200
2417625-2	1985	Correlated exchange under an EX1 regime was observed only for the most slowly exchanging protons in the central hydrogen bonds of the antiparallel beta-sheet and only over a narrow range of temperature and p2H, i.e., above ca.	Hydrogen	112-120	FERM domain containing 6	Homo sapiens	29-32
4063376-0	1985	Assignment of heme and distal amino acid resonances in the 1H-NMR spectra of the carbon monoxide and oxygen complexes of sperm whale myoglobin.	Hydrogen	59-61	myoglobin	Physeter catodon	133-142
4077438-6	1985	In tissues which contain both fat and water, the chemically shifted 1H resonance peaks from -OH and -CH-are in phase with symmetric spin echo sequences but out of phase with asymmetric sequences.	Hydrogen	68-70	FAT atypical cadherin 1	Rattus norvegicus	30-33
3966805-7	1985	Analysis of the Km and Vmax of glucocerebrosidase at various hydrogen ion concentrations revealed that the heat-stable factor and phosphatidylserine together dramatically increase the catalytic efficiency (Vmax/Km) of glucocerebrosidase while making apparent three ionizable groups that participate in the catalysis.	Hydrogen	61-69	glucosylceramidase beta	Rattus norvegicus	31-49
3966805-7	1985	Analysis of the Km and Vmax of glucocerebrosidase at various hydrogen ion concentrations revealed that the heat-stable factor and phosphatidylserine together dramatically increase the catalytic efficiency (Vmax/Km) of glucocerebrosidase while making apparent three ionizable groups that participate in the catalysis.	Hydrogen	61-69	glucosylceramidase beta	Rattus norvegicus	218-236
3930838-11	1985	The sepiapterin reductase catalyzed the transfer of the pro-S hydrogen of NADPH during the reduction of sepiapterin to BH2.	Hydrogen	62-70	sepiapterin reductase	Homo sapiens	4-25
6209138-0	1984	Two-dimensional 1H NMR of two chemically modified analogs of the basic pancreatic trypsin inhibitor.	Hydrogen	16-18	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	82-99
6209138-2	1984	Two-dimensional nuclear magnetic resonance was used to obtain sequence specific assignments for the 1H NMR spectra of two chemically modified analogs of the basic pancreatic trypsin inhibitor.	Hydrogen	100-102	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	174-191
6209139-0	1984	Amide-proton exchange studies by two-dimensional correlated 1H NMR in two chemically modified analogs of the basic pancreatic trypsin inhibitor.	Hydrogen	60-62	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	126-143
6498167-0	1984	Conformational differences between various myoglobin ligated states as monitored by 1H NMR spectroscopy.	Hydrogen	84-86	myoglobin	Physeter catodon	43-52
6465896-4	1984	However, during the early stages of thermolysin digestion of HCS(hPL), both difference and second-order absorption spectra do indicate the transient presence of a similar hydrogen-bonded Trp-carboxylate complex.	Hydrogen	171-179	holocarboxylase synthetase	Homo sapiens	61-64
6746625-0	1984	A 1H NMR comparison of the met-cyano complexes of elephant and sperm whale myoglobin.	Hydrogen	2-4	myoglobin	Physeter catodon	75-84
6746625-2	1984	The met-cyano complex of elephant myoglobin has been investigated by high field 1H NMR spectroscopy, with special emphasis on the use of exchangeable proton resonances in the heme cavity to obtain structural information on the distal glutamine.	Hydrogen	80-82	myoglobin	Physeter catodon	34-43
6466635-1	1984	Butyryl-CoA dehydrogenase from Megasphera elsdenii catalyzes the exchange of the alpha- and beta-hydrogens of substrate with solvent [Gomes, B., Fendrich, G., &amp; Abeles, R. H. (1981) Biochemistry 20, 1481-1490].	Hydrogen	97-106	acyl-CoA dehydrogenase short chain	Sus scrofa	0-25
6487436-1	1984	The relationship between neuronal epileptic activity and regional cerebral blood flow was studied by means of hydrogen clearance method (rCBF).	Hydrogen	110-118	CCAAT/enhancer binding protein zeta	Rattus norvegicus	137-141
6380217-6	1984	Regional cerebral blood flow (rCBF) was assessed by the heat clearance and H2 clearance methods.	Hydrogen	75-77	CCAAT/enhancer binding protein zeta	Rattus norvegicus	30-34
17742920-3	1984	In hydrogen-evolving photoelectrodes, electron-hole pairs photogenerated in the semiconductor are separated at electrical microcontacts between the semiconductor and group VIII metal catalyst islands.	Hydrogen	3-11	cytochrome c oxidase subunit 8A	Homo sapiens	172-176
6312971-2	1983	The interaction between eukaryotic cytochrome c and the tryptic fragment of bovine liver microsomal cytochrome b5 was studied by 1H-n.m.r.	Hydrogen	129-131	LOC104968582	Bos taurus	35-47
6306250-0	1983	Assignment of the 1H nuclear magnetic resonance spectrum of the proteinase inhibitor IIA from bull seminal plasma by two-dimensional nuclear magnetic resonance at 500 MHz.	Hydrogen	18-20	endogenous retrovirus group K member 18	Homo sapiens	64-74
6838819-0	1983	Structure of hen phosvitin: A 31P NMR, 1H NMR, and laser photochemically induced dynamic nuclear polarization 1H NMR study.	Hydrogen	39-41	casein kinase 2 beta	Homo sapiens	17-26
6838819-0	1983	Structure of hen phosvitin: A 31P NMR, 1H NMR, and laser photochemically induced dynamic nuclear polarization 1H NMR study.	Hydrogen	110-112	casein kinase 2 beta	Homo sapiens	17-26
6282258-1	1982	Rat liver ornithine aminotransferase is found to exchange the pro-S hydrogen on the delta-carbon atom of ornithine exclusively, thus showing that the mammalian enzyme transfers the delta-amino group and not the alpha-amino group as has been demonstrated with the plant enzyme [Mestichelli, Gupta &amp; Spenser (1979) J. Biol.	Hydrogen	68-76	ornithine aminotransferase	Homo sapiens	10-36
6895053-3	1981	The hydrogen in the NADH generated is transferred by diaphorase (EC 1.6.4.3) to nitrotetrazolium blue to yield diformazan 540 nm).	Hydrogen	4-12	dihydrolipoamide dehydrogenase	Homo sapiens	53-63
574134-4	1979	G-6-PD activity was measured in the presence and absence of an intermediate hydrogen acceptor, phenazine methosulphate, to provide a measure of the quantity of Type I and Type II Hydrogen (H) generated: Type I H is considered to be related to hydroxylating reactions such as those of steroids and Type II H to other general biosynthetic activities of cells.	Hydrogen	76-84	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-6
574134-4	1979	G-6-PD activity was measured in the presence and absence of an intermediate hydrogen acceptor, phenazine methosulphate, to provide a measure of the quantity of Type I and Type II Hydrogen (H) generated: Type I H is considered to be related to hydroxylating reactions such as those of steroids and Type II H to other general biosynthetic activities of cells.	Hydrogen	179-187	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-6
352081-2	1978	Somatostatin 0.5-5 microgram kg-1h-1 produced a dose dependent reduction of both acid and pepsin secretions stimulated by insulin 0.2 u kg-1h-1.	Hydrogen	32-34	insulin	Felis catus	122-129
352081-2	1978	Somatostatin 0.5-5 microgram kg-1h-1 produced a dose dependent reduction of both acid and pepsin secretions stimulated by insulin 0.2 u kg-1h-1.	Hydrogen	139-141	insulin	Felis catus	122-129
352081-5	1978	The results indicate that somatostatin is a more potent inhibitor of insulin 0.2 u kg-1h-1 stimulated acid secretion than pentagastrin 8 microgram kg-1h-1 stimulated acid secretion, but is a more potent inhibitor of pentagastrin--than insulin--stimulated pepsin secretion.	Hydrogen	86-88	insulin	Felis catus	69-76
658047-0	1978	A 1H nuclear-magnetic-resonance study of the conformation and the molecular dynamics of the glycoprotein cow-colostrum trypsin inhibitor.	Hydrogen	2-4	colostrum trypsin inhibitor	Bos taurus	109-136
658047-1	1978	The glycoprotein cow colostrum trypsin inhibitor was investigated by high resolution 1H nuclear magnetic resonance (NMR) at 360 MHz and, on the basis of the NMR data, compared with the basic pancreatic trypsin inhibitor (Kunitz) from bovine tissue.	Hydrogen	85-87	colostrum trypsin inhibitor	Bos taurus	21-48
20928-0	1977	Ca2+ and Mg2+ dependent conformations of troponin C as determined by 1H and 19F nuclear magnetic resonance.	Hydrogen	69-71	mucin 7, secreted	Homo sapiens	9-12
198987-7	1977	Lactate dehydrogenase and alcohol dehydrogenases from yeast and horse liver do not catalize hydrogen transfer from their substrates to any other alkyl analog but [4-(3-acetylpyridinio)-n-butyl]adenosine pyrophosphate, aldehyde dehydrogenase from horse liver catalizes hydrogen transfer from acetaldehyde to the pentyl derivative and glyceraldehyde-3-phosphate dehydrogenase catalizes hydrogen transfer to both analogs.	Hydrogen	10-18	glyceraldehyde-3-phosphate dehydrogenase	Equus caballus	333-373
198987-7	1977	Lactate dehydrogenase and alcohol dehydrogenases from yeast and horse liver do not catalize hydrogen transfer from their substrates to any other alkyl analog but [4-(3-acetylpyridinio)-n-butyl]adenosine pyrophosphate, aldehyde dehydrogenase from horse liver catalizes hydrogen transfer from acetaldehyde to the pentyl derivative and glyceraldehyde-3-phosphate dehydrogenase catalizes hydrogen transfer to both analogs.	Hydrogen	36-44	glyceraldehyde-3-phosphate dehydrogenase	Equus caballus	333-373
198987-7	1977	Lactate dehydrogenase and alcohol dehydrogenases from yeast and horse liver do not catalize hydrogen transfer from their substrates to any other alkyl analog but [4-(3-acetylpyridinio)-n-butyl]adenosine pyrophosphate, aldehyde dehydrogenase from horse liver catalizes hydrogen transfer from acetaldehyde to the pentyl derivative and glyceraldehyde-3-phosphate dehydrogenase catalizes hydrogen transfer to both analogs.	Hydrogen	36-44	glyceraldehyde-3-phosphate dehydrogenase	Equus caballus	333-373
14667-1	1977	The hydrogen ion activity within isolated chromaffin granules can be estimated from the distribution of the weak base methylamine and from phosphorus-31 nuclear magnetic resonance spectra of ATP contained in the granules.	Hydrogen	4-12	ATPase phospholipid transporting 8A2	Homo sapiens	191-194
618355-6	1977	The changes in the ODC"s are thought to be secondary to the hyperchylomicronemia for the following reasons: (1) the change was minimized by incubating red cells from the patients in normal donor plasma; (2) normal red cells increased their oxygen affinity when incubated in lactescent plasma; (3) the change was not explainable by a decrease in red cell 2,3-diphosphoglycerate content or in arterial blood hydrogen ion concentration.	Hydrogen	406-414	ornithine decarboxylase 1	Homo sapiens	19-22
6891122-2	1982	Progesterone treatment of estrogen-primed fetuses leads to a rapid (before 1h) transfer of cytosol progesterone receptor into the nucleus which is, however, short-lived (less than 3h).	Hydrogen	75-77	LOW QUALITY PROTEIN: progesterone receptor	Cavia porcellus	99-120
6951186-0	1982	Hydrogen exchange in RNase A: neutron diffraction study.	Hydrogen	0-8	ribonuclease A family member 1, pancreatic	Homo sapiens	21-28
6951186-1	1982	Hydrogen exchange has been studied in a single crystal of RNase A [ribonuclease (pancreatic), EC 3.1.27.5] in the course of a neutron structure investigation.	Hydrogen	0-8	ribonuclease A family member 1, pancreatic	Homo sapiens	58-65
6800386-4	1981	The rCBF in the thalamus was measured by the initial slope method of hydrogen clearance curves.	Hydrogen	69-77	CCAAT/enhancer binding protein zeta	Rattus norvegicus	4-8
6795631-5	1981	The diene character of some of the metabolites formed suggests another role for cytochrome P-450--i.e., participation in hydrogen abstraction reactions for the activation of various substrates.	Hydrogen	121-129	cytochrome P450, family 2, subfamily c, polypeptide 12	Rattus norvegicus	80-99
6165013-11	1981	The resistance of the 5" end of U-1 RNA to T1 RNase was unexpected inasmuch as this region has been implicated in hydrogen bonding with heterogeneous nuclear RNA splice junctions.	Hydrogen	114-122	RNA, U1 small nuclear 1	Homo sapiens	32-35
7036106-4	1981	On the basis of this observation, the tritium labeling of GnRH and angiotensin I by direct catalytic hydrogen-tritium exchange was found to be useful for the labeling of these peptides at remarkably high specific radioactivity.	Hydrogen	101-109	gonadotropin releasing hormone 1	Homo sapiens	58-62
6776792-10	1980	From these studies the following conclusions can be reached: 1)a low lactose breath hydrogen test in the postgastrectomy subject correctly identifies the individual with normal lactase activity.	Hydrogen	84-92	lactase	Homo sapiens	177-184
6776792-11	1980	However, high breath hydrogen responses, may be found in either those with lactase deficiency or normal lactase activity.	Hydrogen	21-29	lactase	Homo sapiens	75-82
518909-2	1979	1H-NMR spectra have been recorded for sperm whale met-aquo myoglobin intercalated with xenon, cyclopropane, mercuric triiodide and auric triiodide.	Hydrogen	0-2	myoglobin	Physeter catodon	59-68
458815-2	1979	Low-energy conformers of carbinol substituents on C7-C19-R1R2OH are found with and without intramolecular hydrogen bonding to the C6-OCH3 group.	Hydrogen	106-114	complement C6	Homo sapiens	130-143
43839-0	1979	Hydrogen-tritium exchange titration of the histidine residues in bovine heart cytochrome c and analysis of their microenvironment.	Hydrogen	0-8	LOC104968582	Bos taurus	78-90
710579-0	1978	Structure determination of the single glycan of rabbit serotransferrin by methylation analysis and 360 MHz 1H NMR spectroscopy.	Hydrogen	107-109	serotransferrin	Oryctolagus cuniculus	55-70
657494-4	1978	The hydrogen in the generated NADH is transferred by diaphorase (EC 1.6.4.3) to resazurin to yield resorfin, the fluorophore.	Hydrogen	4-12	dihydrolipoamide dehydrogenase	Homo sapiens	53-63
80938-1	1978	High resolution 13C and 1H NMR spectra of myelin basic protein over a range of pH and concentrations indicate that intramolecular folding of the polypeptide chain occurs in aqueous solution in the region of residues 85 to 116.	Hydrogen	24-26	myelin basic protein	Homo sapiens	42-62
680727-6	1978	The failure of dealkylative nitrosation reactions in the latter tetracyclines is explained by the formation of intramolecular hydrogen bridge linkages between epidimethylamino groups at C-4 and OH groups at C-6.	Hydrogen	126-134	complement C6	Homo sapiens	207-210
301904-3	1977	The anti-Lac B precursor cells from BALB/c (H-2)d mice which survive cytotoxic treatment with anti-Iak and complement will respond to Lac-KLH in culture but require more KLH helper T cells than unselected B cell populations or B cells surviving anti-Ig killing.	Hydrogen	44-47	aurora kinase A	Mus musculus	99-102
835150-7	1977	It is possible that H2 electrodes provide low values for supposedly "cortical" rCBF in the very small mouse brain, because is such brains the electrode is usually close enough to a slow clearing compartment for the electrode reading to be influenced by that compartment.	Hydrogen	20-22	CCAAT/enhancer binding protein zeta	Rattus norvegicus	79-83
185137-1	1976	The stereochemistry of the hydrogen transfer to NAD catalyzed by ribitol dehydrogenase (ribitol:NAD 2-oxidoreductase, EC 1.1.1.56) from Klebsiella pneumoniae and D-mannitol-1-phosphate dehydrogenase (D-mannitol-1-phosphate:NAD 2-oxidoreductase, EC 1.1.1.17) from Escherichia coli was investigated.	Hydrogen	27-35	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	102-116
185137-1	1976	The stereochemistry of the hydrogen transfer to NAD catalyzed by ribitol dehydrogenase (ribitol:NAD 2-oxidoreductase, EC 1.1.1.56) from Klebsiella pneumoniae and D-mannitol-1-phosphate dehydrogenase (D-mannitol-1-phosphate:NAD 2-oxidoreductase, EC 1.1.1.17) from Escherichia coli was investigated.	Hydrogen	27-35	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	229-243
185137-8	1976	When L-iditol dehydrogenase utilizes ribitol as hydrogen donor, the same A-type classification for this oxidoreductase, as expected, holds true.	Hydrogen	16-24	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	104-118
1238108-13	1975	There is strong evidence that one of the two tryptophans whose identity and structural role in myoglobin is known, is present also in plant leghemoglobins, hydrogen-bonded and in a similar nonpolar environment whether heme is present or not.	Hydrogen	156-164	myoglobin	Physeter catodon	95-104
1239731-3	1975	The renal vein renin concentration was 673 +/- 81 (SE) ng ml-1h-1 which was significantly higher than the concentration in the aorta of 456 +/- 50 (SE) ng ml-1h-1.	Hydrogen	61-63	renin	Rattus norvegicus	15-20
1239731-3	1975	The renal vein renin concentration was 673 +/- 81 (SE) ng ml-1h-1 which was significantly higher than the concentration in the aorta of 456 +/- 50 (SE) ng ml-1h-1.	Hydrogen	158-160	renin	Rattus norvegicus	15-20
4831886-0	1974	Studies on hydrogen-deuterium exchange in basic trypsin inhibitor.	Hydrogen	11-19	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	48-65
4722437-4	1973	The relative inhibition constants of d-glucose and its deoxy, epimeric and fluorinated analogues are consistent with the combination of beta-d-glucopyranose with the carrier by hydrogen bonds at C-1, C-3, probably C-4, and possibly C-6 of the sugar.	Hydrogen	177-185	complement C6	Homo sapiens	232-235
5012976-0	1972	Mechanism of the isotopic exchange of the C-8 hydrogen of purines in nucleosides and in deoxyribonucleic acid.	Hydrogen	46-54	homeobox C8	Homo sapiens	42-45
11826889-2	1970	Fat is most efficient because it has a higher ratio of carbon and hydrogen to oxygen than do protein and carbohydrate, so stored food systems for long missions would logically rely heavily on this form of calories.	Hydrogen	66-74	FAT atypical cadherin 1	Homo sapiens	0-3
5671066-0	1968	Hydrogen ion equilibria and sedimentation behavior of goat beta-lactoglobulin.	Hydrogen	0-8	beta-lactoglobulin	Capra hircus	59-77
20068706-3	1968	The fluorescence, excitation, and absorption spectra of FAP:Nd are partially polarized, as expected for Nd(3+) substituting Ca II sites of C(1h) symmetry.	Hydrogen	141-143	fibroblast activation protein alpha	Homo sapiens	56-59
13997-3	1977	By 1H nuclear magnetic resonance spectroscopy it has been shown that phenylpyruvate tautomerase from beef kidney catalyses the stereospecific exchange of one of the enantiotopic 3H-atoms in the side-chain of the substrate with solvent protons, the rate of spontaneous exchange being slow under physiological conditions.	Hydrogen	3-5	macrophage migration inhibitory factor	Homo sapiens	69-95
8143-7	1976	It was concluded from the results of purification, electrofocusing and inhibition studies that glutathione reductase is a single enzyme which used both NADPH and NADH as hydrogen donors.	Hydrogen	170-178	glutathione-disulfide reductase	Homo sapiens	95-116
7783-6	1976	The results demonstrate a novel hydrogen transport system in E. coli consisting of NADPH, glutathione, glutathione reductase, and a heat-stable enzyme called "glutaredoxin".	Hydrogen	32-40	glutaredoxin	Homo sapiens	159-171
2826431-8	1987	The 1H NMR spectrum of peaks representing amide hydrogens of the carboxyl-terminal Arg-74, Gly-75, and Gly-76 of the processed mono-ubiquitin was identical with that of human ubiquitin.	Hydrogen	4-6	ubiquitin	Saccharomyces cerevisiae S288C	132-141
4855440-0	1974	1H nmr study on the binding of CMP inhibitors to RNase A.	Hydrogen	0-2	ribonuclease A family member 1, pancreatic	Homo sapiens	49-56
17837562-0	1954	Appeal to the Western Evolutionists against the Hydrogen Bomb by the Japanese Society for the Study of Organic Evolution.	Hydrogen	48-56	WW and C2 domain containing 2	Homo sapiens	57-61
2826431-8	1987	The 1H NMR spectrum of peaks representing amide hydrogens of the carboxyl-terminal Arg-74, Gly-75, and Gly-76 of the processed mono-ubiquitin was identical with that of human ubiquitin.	Hydrogen	4-6	ubiquitin	Saccharomyces cerevisiae S288C	175-184
2826431-8	1987	The 1H NMR spectrum of peaks representing amide hydrogens of the carboxyl-terminal Arg-74, Gly-75, and Gly-76 of the processed mono-ubiquitin was identical with that of human ubiquitin.	Hydrogen	48-57	ubiquitin	Saccharomyces cerevisiae S288C	132-141
13192314-0	1954	The position of the cell nucleus in pathways of hydrogen transfer: cytochrome C, flavoproteins, glutathione, and ascorbic acid.	Hydrogen	48-56	LOC104968582	Bos taurus	67-79
2826431-8	1987	The 1H NMR spectrum of peaks representing amide hydrogens of the carboxyl-terminal Arg-74, Gly-75, and Gly-76 of the processed mono-ubiquitin was identical with that of human ubiquitin.	Hydrogen	48-57	ubiquitin	Saccharomyces cerevisiae S288C	175-184
14332045-0	1965	[STUDIES ON THE COURSE OF THE ATPASE REACTION WITH THE APPEARANCE OF HYDROGEN IONS IN THE MEDIUM].	Hydrogen	69-77	dynein axonemal heavy chain 8	Homo sapiens	30-36
2854260-2	1987	The intact form of protein C inhibitor was predicted with an alpha-carbon model based on its hydrophilicity and hydrogen bond pattern.	Hydrogen	112-120	serpin family A member 5	Homo sapiens	19-38
14165900-0	1964	KINETICS OF HYDROGEN TRANSFER BETWEEN HYPOXANTHINE AND DIMETHYLBIACRIDYLIUM NITRATE IN THE PRESENCE OF CHICK LIVER XANTHINE DEHYDROGENASE.	Hydrogen	12-20	xanthine dehydrogenase	Gallus gallus	115-137
19312020-0	1937	The Investigation of Intermediary Metabolism with the Aid of Heavy Hydrogen: Harvey Lecture, January 21, 1937.	Hydrogen	67-75	activation induced cytidine deaminase	Homo sapiens	54-57
3427016-2	1987	The most significant effects of binding were large downfield shifts in the amino nitrogen resonance of Phe-3 of vasopressin and in its associated proton, providing evidence that the peptide bond between residues 2 and 3 of the hormones is hydrogen-bonded to the protein within hormone-neurophysin complexes.	Hydrogen	239-247	dihydrolipoamide dehydrogenase	Homo sapiens	103-108
33548783-6	2021	X-ray spectroscopy data and DFT calculations illustrated that the adsorption of SSA on MIP-4 was mainly dependent on the strong electrostatic interaction between the protonated amine group on the resin and -SO3- of SSA, as well as, the hydrogen bond between the neutral amine group and -OH and -COOH of SSA; the order of the three functional groups in identification was -OH > -COOH > -SO3H.	Hydrogen	236-244	C-C motif chemokine ligand 18	Homo sapiens	87-92
33838788-3	2021	The structure of COS-g-Cit1-3 was confirmed by UV-vis, FT-IR, 1H NMR and elemental analysis.	Hydrogen	62-64	COPG2 imprinted transcript 1	Homo sapiens	23-29
33619758-7	2021	These RBD residues also engage in significant hydrogen bonding with the human receptor ACE2.	Hydrogen	46-54	angiotensin converting enzyme 2	Homo sapiens	87-91
3116836-7	1987	Peak hydrogen excretion after consumption of frozen yogurt with high beta-gal was less than one-half of that observed after the other five test meals and intolerance symptoms were absent.	Hydrogen	5-13	galactosidase beta 1	Homo sapiens	69-77
33988965-2	2021	In the present work, the hydrogen storage mechanism and structural transformations of core (Pd)-shell (Pt) (CS) and solid-solution (SS) NPs during hydrogen absorption and desorption (PHAD) processes are investigated.	Hydrogen	147-155	citrate synthase	Homo sapiens	108-110
34037039-8	2021	In addition, molecular docking results confirmed that 25 dipeptides mainly interacted with the core targets (ALB, JAK2, and STAT3) by hydrogen-bonding interactions.	Hydrogen	134-142	Janus kinase 2	Homo sapiens	114-118
2891832-0	1987	Dipole-mediated hydrogen bonding interactions between cimetidine analogues and the histamine H2 receptor.	Hydrogen	16-24	histamine receptor H2	Homo sapiens	83-104
34022432-0	2021	Revealing the dynamic allosteric changes required for formation of the cysteine synthase complex by hydrogen-deuterium exchange mass spectrometry.	Hydrogen	100-108	citrate synthase	Homo sapiens	71-88
34027667-4	2021	The results from the molecular dynamics study shows that tozasertib-Aurora kinase A complex is stabilized through hydrogen bonding, polar interactions, and water bridges.	Hydrogen	114-122	aurora kinase A	Rattus norvegicus	68-83
3124004-4	1987	The substitution of deuterium for hydrogens in the alpha-carbon of the alkyl-side chain of phenylethylamines decreases the rate of deamination by MAO.	Hydrogen	34-43	monoamine oxidase A	Rattus norvegicus	146-149
33746012-8	2021	(S)-flurbiprofen was easy to form stronger hydrogen bonding with -CONH group of skin lipids due to its steric configuration, which disturbed lipids arrangement more easily according to the results of ATR-FTIR (DeltanuasCH2 = 1.00 cm-1), Raman spectra (Delta I2882/I2853= 0.32) and the DSC (DeltaTm stratum corneum = 11.75  C).	Hydrogen	43-51	ATR serine/threonine kinase	Rattus norvegicus	200-203
33957043-3	2021	Electron-rich histidine acted as a Lewis base effectively immobilizing Co2+ (Lewis acid) via the electrostatic effect and hydrogen bonds, thus achieving the scalable synthesis of Co-SAs-HCS.	Hydrogen	122-130	holocarboxylase synthetase	Homo sapiens	186-189
16665718-5	1987	In a related type reaction, purothionin, inhibited the activity of either Escherichia coli or calf thymus ribonucleotide reductase with reduced thioredoxin as hydrogen donor.	Hydrogen	159-167	thioredoxin	Bos taurus	144-155
33979162-3	2021	By performing all-atom molecular dynamics (MD) simulations, we identified an extended network of salt bridges, hydrophobic and electrostatic interactions, and hydrogen bonds between the receptor-binding domain (RBD) of the S protein and ACE2.	Hydrogen	159-167	angiotensin converting enzyme 2	Homo sapiens	237-241
33953162-5	2021	Structural and Hydrogen-Deuterium-Exchange mass spectrometry analyses demonstrate antibody interaction with an N-terminal region of CXCR2 that is part of the IL-8 epitope.	Hydrogen	15-23	chemokine (C-X-C motif) ligand 15	Mus musculus	158-162
33984041-6	2021	Hydrogen bonding, salt-bridge and water mediated interactions supported by MM-GBSA free energy of binding revealed strong binding of cordifolide A and sitoindoside IX to RdRP.	Hydrogen	0-8	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	170-174
3611103-3	1987	When the reaction catalyzed by 5-oxoprolinase of Pseudomonas putida was carried out to 90% completion in H2(18)O, the residual 5-oxoproline was found to contain 18O in the amide carbonyl oxygen atom.	Hydrogen	105-107	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	31-45
33980604-4	2021	Substrate pharmacophores for ENT1 and ENT2 are distinct, with partial overlap of hydrogen bond donors, while the inhibitor pharmacophores predominantly feature hydrogen bond acceptors.	Hydrogen	81-89	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	29-33
34022685-5	2021	Further experiments showed that 6:2 Cl-PFESA formed more hydrogen bonds with PPAR-gamma than PFOS, Rosi and GW9662, and the binding affinity of 6:2 Cl-PFESA toward PPAR-gamma was the highest among the ligands.	Hydrogen	57-65	peroxisome proliferator activated receptor gamma	Mus musculus	77-87
32329410-6	2021	In addition, the hydrogen bond interaction is the pivotal factor for the Kv1.3-Kaliotoxin association.	Hydrogen	17-25	potassium voltage-gated channel subfamily A member 3	Homo sapiens	73-78
3746811-4	1986	The 4-alkyl compounds, in contrast, formed a pyridine derivative in which a hydrogen atom was present at the 4-position and the alkyl group was lost; these compounds also inactivated cytochrome P-450 and caused the loss of nifedipine oxidase activity after enzymatic oxidation.	Hydrogen	76-84	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	194-199
33965498-5	2021	The procyanidine effectively inhibited the aggregation of hIAPP and Abeta through hydrophobic and hydrogen bonding interactions, it dissolved the aged fibrils into nanoscale particles.	Hydrogen	98-106	islet amyloid polypeptide	Homo sapiens	58-63
3800936-19	1986	Its mechanism of formation probably involves hydrogen atom abstraction by .OH radicals from the C-5" of the 2"-deoxyguanosine moiety followed by intramolecular cyclization with the formation of a covalent bond between the C-5" and C-8 and subsequent oxidation of the resulting N-7-centred radical.	Hydrogen	45-53	homeobox C8	Homo sapiens	231-234
33599060-6	2021	There are only two of four possible intramolecular hydrogen bonds formed, namely, between Aib4 and Gly1 forming a beta-turn of type III" and between Aib6 and Gly3 forming a beta-turn of type I.	Hydrogen	51-59	threonine aldolase 1, pseudogene	Homo sapiens	99-103
33987026-7	2021	Molecular dynamics simulations indicated that the MMF bond with COX-2 was stable, as evidenced by a low root-mean-square deviation of atomic positions, complementary per-residue root-mean-square fluctuation, and 0-4 hydrogen bonds during the 50-ns simulation time.	Hydrogen	216-224	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	64-69
3709529-0	1986	Typing of core and backbone domains of mucin-type oligosaccharides from human ovarian-cyst glycoproteins by 500-MHz 1H-NMR spectroscopy.	Hydrogen	116-118	LOC100508689	Homo sapiens	39-44
33935562-4	2021	The molecular simulation dynamics analysis of doxorubicin, Reference Mean Square Deviation (RMSD), Root Mean Square fluctuation (RMSF), Radius of Gyration (Rg), and formation of hydrogen bonds plot interpretation suggested, a significant deviation and fluctuation of Doxorubicin-Spike RBD complex during the whole simulation period.	Hydrogen	178-186	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	279-284
3697358-3	1986	Since OSCN- can form the weak acid HOSCN (pKa = 5.3), the equilibrium constant expression (Kox) for thiocyanate peroxidation is dependent on the concentration of hydrogen ions as well as the concentrations of H2O2, SCN-, HOSCN, OSCN- and water, and on the HOSCN ionization constant, Ka: (Formula: see text).	Hydrogen	162-170	NADPH oxidase 4	Homo sapiens	91-94
33926020-6	2021	The binding affinity of ADL and beta-CD was confirmed by 1H NMR and 2D ROSEY studies.	Hydrogen	57-59	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	32-39
33899541-4	2021	An atherosclerosis model in vitro was constructed by ox-LDL-induced injury of human umbilical vein endothelial cells and in vitro testing indicated hydrogen inhibited ox-LDL-induced oxidative stress and inflammatory response by down-regulating LOX-1/NF-kB signaling pathway.	Hydrogen	148-156	oxidized low density lipoprotein receptor 1	Homo sapiens	244-249
3934358-2	1985	The present study is aimed at redefining lactase insufficiency by comparing intestinal lactase activity and results of the lactose breath hydrogen test.	Hydrogen	138-146	lactase	Homo sapiens	41-48
3934358-3	1985	Primary "insufficient" lactase activity was considered to be present when a child with a normal small bowel histology showed lactose malabsorption as measured by the lactose breath hydrogen test.	Hydrogen	181-189	lactase	Homo sapiens	23-30
3878727-4	1985	Ca(II) binding broadens all 1H resonances, so severely at four Ca(II) ions per molecule that few structural conclusions can be made.	Hydrogen	28-30	carbonic anhydrase 2	Bos taurus	0-5
33922914-10	2021	Analysis of the RBD-DK07 interaction suggested the formation of hydrogen bonds, electrostatic interactions, and hydrophobic interactions with key residues mediating the ACE2-RBD interaction.	Hydrogen	64-72	angiotensin converting enzyme 2	Homo sapiens	169-173
33874887-11	2021	RESULTS: The pancreatic pathological changes, plasma amylase and lipase activity, and the increase of plasma IL-1 and IL-6 levels in AP mice were significantly improved by the hydrogen-rich gases pretreatment, Meanwhile, the pancreatic GSH content increased and the pancreatic MDA content decreased.	Hydrogen	176-184	interleukin 1 complex	Mus musculus	109-113
3878727-4	1985	Ca(II) binding broadens all 1H resonances, so severely at four Ca(II) ions per molecule that few structural conclusions can be made.	Hydrogen	28-30	carbonic anhydrase 2	Bos taurus	0-6
33092925-7	2021	Hydrogen bonds and electrostatic interactions may play vital roles in blocking the receptor ACE2 binding with SARS-CoV-2.	Hydrogen	0-8	angiotensin converting enzyme 2	Homo sapiens	92-96
3888618-4	1985	Sepiapterin reductase catalyzed the transfer of the pro-S hydrogen of NADPH during the reduction of sepiapterin to 7,8-dihydrobiopterin.	Hydrogen	58-66	sepiapterin reductase	Homo sapiens	0-21
33921209-8	2021	GLP-1 and gastrin decrease the expression of Na+-K+/ATPase and increase the phosphorylation of sodium/hydrogen exchanger type 3 (NHE3) in human renal proximal tubule cells (hRPTCs).	Hydrogen	102-110	glucagon like peptide 1 receptor	Homo sapiens	0-5
3882669-3	1985	Transconjugants containing the nif/hup cosmid were identified by their resistance to tetracycline (Tcr) and ability to grow chemoautotrophically (Aut+) with hydrogen.	Hydrogen	157-165	DNA-binding protein HU	Escherichia coli	35-38
33867777-3	2021	Ivermectin binds with LEU492, GLN493, GLY496, and TRY505 residues in the spike protein through hydrogen bonds and levosalbutamol binds with TYR453 and TYR505 residues.	Hydrogen	95-103	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	73-78
3882669-12	1985	These results indicate that the nif/hup gene cosmids contain a gene involved in both nitrogenase and hydrogenase activities and at least one and perhaps other hup genes which are exclusively involved in H2 uptake activity.	Hydrogen	203-205	DNA-binding protein HU	Escherichia coli	36-39
33917059-4	2021	In addition, we characterize through the hydrogen/deuterium (H/D) exchange assay the interface between Scs2 and Epo1.	Hydrogen	41-49	phosphatidylinositol-binding protein SCS2	Saccharomyces cerevisiae S288C	103-107
3882669-12	1985	These results indicate that the nif/hup gene cosmids contain a gene involved in both nitrogenase and hydrogenase activities and at least one and perhaps other hup genes which are exclusively involved in H2 uptake activity.	Hydrogen	203-205	DNA-binding protein HU	Escherichia coli	159-162
3967655-2	1985	400-MHz 1H-NMR spectra revealed characteristic changes which show that the conformation of actin alters by exchanging Ca2+ for Mg2+ in the single high-affinity cation binding site.	Hydrogen	8-10	mucin 7, secreted	Homo sapiens	127-130
33918458-6	2021	These results indicated electrostatic interaction and hydrogen bonding between chitosan and mucin on the mucosa.	Hydrogen	54-62	LOC100508689	Homo sapiens	92-97
33439102-10	2021	Sirt1 induction by molecular hydrogen via the HO-1/AMPK/PPARalpha/PPARgamma pathway suppresses palmitate-mediated abnormal fat metabolism.	Hydrogen	29-37	peroxisome proliferator activated receptor gamma	Mus musculus	66-75
6514011-4	1984	Replacement of the para-hydrogen atom in the mexiletine aromatic ring by bromine increased potency towards both MAO-A and SSAO.	Hydrogen	24-32	monoamine oxidase A	Rattus norvegicus	112-117
32935194-0	2021	1H, 13C, 15 N backbone resonance assignment of the recognition lobe subdomain 3 (Rec3) from Streptococcus pyogenes CRISPR-Cas9.	Hydrogen	0-2	type II CRISPR RNA-guided endonuclease Cas9	Streptococcus pyogenes	122-126
6370138-3	1984	Conversely, when hydrogenase activity is mediated by polyanionic metatungstate or ferredoxin, H2 production is strongly inhibited by anions (e.g., 70-77% inhibition by 0.2 M NaCl).	Hydrogen	94-96	uncharacterized protein	Chlamydomonas reinhardtii	82-92
32718369-2	2021	The removal of molecular hydrogen (H2) by methanogenesis is postulated to eliminate the inhibitory effect of H2 on the microbial degradation of feed material.	Hydrogen	25-33	anon-H2	Drosophila melanogaster	35-37
32718369-2	2021	The removal of molecular hydrogen (H2) by methanogenesis is postulated to eliminate the inhibitory effect of H2 on the microbial degradation of feed material.	Hydrogen	25-33	anon-H2	Drosophila melanogaster	109-111
33608073-3	2021	While in the presence of Pb(II), the G-quadruplex structure originating from two G-quartet planes by the intramolecular hydrogen bond with Pb(II) also causes the HEX approaching the (G)4 terminal and consequently the fluorescence quenching.	Hydrogen	120-128	hematopoietically expressed homeobox	Homo sapiens	162-165
6202020-5	1984	The degree of affinity of GAGs for PF4 (heparin greater than DeS greater than HS) seems to correlate with PF4 release.	Hydrogen	78-80	platelet factor 4	Homo sapiens	35-38
33656879-5	2021	For CYP17A1 with 17OH-PROG, a characteristic shift of the Fe-O mode is observed in the presence of Mn-b5, indicating reorientation of a hydrogen bond between the 17OH group of the substrate from the terminal to the proximal oxygen atom of the Fe-O-O moiety, a configuration favorable for the lyase catalysis.	Hydrogen	136-144	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	4-11
6202020-5	1984	The degree of affinity of GAGs for PF4 (heparin greater than DeS greater than HS) seems to correlate with PF4 release.	Hydrogen	78-80	platelet factor 4	Homo sapiens	106-109
6209415-1	1984	The interaction of the myelin basic protein (MBP) and the major endogenous ganglioside GM1 in myelin of the central nervous system has been investigated using both 500-MHz 1H and 67.89 MHz 13C NMR.	Hydrogen	172-174	myelin basic protein	Homo sapiens	23-43
33162036-8	2021	Combined with other characterizations such as XRD, XPS, SEM and BET, the possible hydrogen production mechanism was proposed.	Hydrogen	82-90	delta/notch like EGF repeat containing	Homo sapiens	64-67
33586743-0	2021	CdS/Ag2S/g-C3N4 ternary composites with superior photocatalytic performance for hydrogen evolution under visible light irradiation.	Hydrogen	80-88	angiotensin II receptor type 1	Homo sapiens	4-8
33586743-3	2021	Compared with the pure samples and binary composites, CdS/Ag2S/g-C3N4 ternary composites showed enhanced hydrogen production activities, and the maximum hydrogen production rate of CdS/Ag2S(2%)/CN is about 1020.54 mumol g-1 h-1 in Na2S-Na2SO3 solution.	Hydrogen	105-113	angiotensin II receptor type 1	Homo sapiens	58-62
33738956-7	2021	A collaborative hydrogen production mechanism via Volmer-Heyrovsky pathway is suggested: Te2 2- adsorbs protons and assists the mass transfer to adjacent Pt atoms where the protons are reduced and released as hydrogen.	Hydrogen	16-24	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	89-92
33738956-7	2021	A collaborative hydrogen production mechanism via Volmer-Heyrovsky pathway is suggested: Te2 2- adsorbs protons and assists the mass transfer to adjacent Pt atoms where the protons are reduced and released as hydrogen.	Hydrogen	209-217	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	89-92
33586743-3	2021	Compared with the pure samples and binary composites, CdS/Ag2S/g-C3N4 ternary composites showed enhanced hydrogen production activities, and the maximum hydrogen production rate of CdS/Ag2S(2%)/CN is about 1020.54 mumol g-1 h-1 in Na2S-Na2SO3 solution.	Hydrogen	153-161	angiotensin II receptor type 1	Homo sapiens	58-62
6209415-1	1984	The interaction of the myelin basic protein (MBP) and the major endogenous ganglioside GM1 in myelin of the central nervous system has been investigated using both 500-MHz 1H and 67.89 MHz 13C NMR.	Hydrogen	172-174	myelin basic protein	Homo sapiens	45-48
33870658-4	2021	Such a design allows Pep-HCO3 ((nap-RAGLQFPVGRLLRRLLRRLLR) nHCO3 ) to self-assemble into nanoparticles (NP-Pep) due to disrupting helix folding and the formation of intermolecular hydrogen bonding between bicarbonates and guanidine groups.	Hydrogen	180-188	prolyl endopeptidase	Mus musculus	21-24
33870658-4	2021	Such a design allows Pep-HCO3 ((nap-RAGLQFPVGRLLRRLLRRLLR) nHCO3 ) to self-assemble into nanoparticles (NP-Pep) due to disrupting helix folding and the formation of intermolecular hydrogen bonding between bicarbonates and guanidine groups.	Hydrogen	180-188	prolyl endopeptidase	Mus musculus	107-110
6414519-1	1983	The 250 MHz 1H-NMR spectrum of horse carbonic anhydrase I (or B) (carbonate hydro-lyase, EC 4.2.1.1) was measured as a function of pH under various conditions.	Hydrogen	12-14	carbonic anhydrase 1	Equus caballus	37-57
33864317-0	2021	Hydrogen-Bonded Complexes of Star Polymers.	Hydrogen	0-8	steroidogenic acute regulatory protein	Homo sapiens	29-33
33864317-1	2021	The effect of molecular architecture, star versus linear, poly(ethylene oxide) (PEO) on the formation of hydrogen-bonded complexes with linear poly(methacrylic acid) (PMAA) is investigated experimentally and rationalized theoretically.	Hydrogen	105-113	steroidogenic acute regulatory protein	Homo sapiens	38-42
33860009-4	2021	The ligand-receptor complexes" accuracy in preventing the Spike (S) protein of SARS-CoV-2 penetration inside the host cells has been analyzed through hydrogen-hydrophobic bond interactions, principal component analysis (PCA), root mean square deviation (RMSD), root mean square fluctuation (RMSF), and B-Factor.	Hydrogen	150-158	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	58-63
33860009-4	2021	The ligand-receptor complexes" accuracy in preventing the Spike (S) protein of SARS-CoV-2 penetration inside the host cells has been analyzed through hydrogen-hydrophobic bond interactions, principal component analysis (PCA), root mean square deviation (RMSD), root mean square fluctuation (RMSF), and B-Factor.	Hydrogen	150-158	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	58-59
33864317-4	2021	These results are rationalized based on a higher localized density of hydrogen bonds formed between sPEO and the polyacid which prevents penetration of star molecules into PMAA coils.	Hydrogen	70-78	steroidogenic acute regulatory protein	Homo sapiens	152-156
6833249-4	1983	We have investigated this hydrogen exchange using palmitoyl-[1-R-3H]DHAP and a 1000-fold purified preparation of alkyl-DHAP synthase.	Hydrogen	26-34	alkylglycerone phosphate synthase	Homo sapiens	113-132
33655750-10	2021	A close match (337 A2) was found for a single low Gibbs energy structure that displayed a binding pocket with Ser 2 and Ser 5 residues forming hydrogen bonds to the adrenaline catechol hydroxyls.	Hydrogen	143-151	jagged canonical Notch ligand 2	Homo sapiens	110-115
32066337-4	2021	The results showed two conditions which appear to be essential that peptides presented ACE inhibition capacity: i) to interact with Zn2+ coordinated residues, such as His383, His387, and Glu411, by short hydrogen bonds, for peptides with high inhibitory capacity in vitro, as ALNEINQFYQK (IACE = 80.7%), NAVPITPTLNR (IACE = 80.7%), and FALPQYLK (IACE = 79.0%); or interact by electrostatic and hydrophobic interactions with the same residues, for peptides with intermediate inhibition capacity in vitro, as HQGLPQEVLNENLLR (IACE = 49.2%), FFVAPFPEVFGK (IACE = 47.8%) and YLGYLEQLLR (IACE = 47.8%); ii) to interact with the S1 active site residues (Ala354, Glu384, and Tyr523) by hydrogen bonds.	Hydrogen	204-212	angiotensin I converting enzyme	Bos taurus	87-90
32066337-4	2021	The results showed two conditions which appear to be essential that peptides presented ACE inhibition capacity: i) to interact with Zn2+ coordinated residues, such as His383, His387, and Glu411, by short hydrogen bonds, for peptides with high inhibitory capacity in vitro, as ALNEINQFYQK (IACE = 80.7%), NAVPITPTLNR (IACE = 80.7%), and FALPQYLK (IACE = 79.0%); or interact by electrostatic and hydrophobic interactions with the same residues, for peptides with intermediate inhibition capacity in vitro, as HQGLPQEVLNENLLR (IACE = 49.2%), FFVAPFPEVFGK (IACE = 47.8%) and YLGYLEQLLR (IACE = 47.8%); ii) to interact with the S1 active site residues (Ala354, Glu384, and Tyr523) by hydrogen bonds.	Hydrogen	679-687	angiotensin I converting enzyme	Bos taurus	87-90
6291598-2	1982	The proton resonances of beta 2, beta 143, and beta 146 histidyl residues are assigned by a parallel 1H NMR titration of appropriate mutant and chemically modified hemoglobins.	Hydrogen	101-103	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	25-31
32902889-5	2021	In comparison with SARS-CoV PLpro , in SARS-CoV-2, the PLpro had a conserved catalytic triad of C111, H278 and D293, with a slightly lower number of polar interface residues and of hydrogen bonds, a higher number of buried interface sizes and a lower number of residues that interact with ubiquitin and PLpro .	Hydrogen	181-189	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	55-60
32902889-5	2021	In comparison with SARS-CoV PLpro , in SARS-CoV-2, the PLpro had a conserved catalytic triad of C111, H278 and D293, with a slightly lower number of polar interface residues and of hydrogen bonds, a higher number of buried interface sizes and a lower number of residues that interact with ubiquitin and PLpro .	Hydrogen	181-189	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	55-60
33916785-8	2021	Molecular docking studies predicted that NDGA would adopt a stable conformation at the COMT active site, mainly owing to the hydrogen bond network.	Hydrogen	125-133	catechol-O-methyltransferase	Homo sapiens	87-91
6126173-0	1982	[H2-antihistaminics, VIII: Synthesis of potential H2-antihistaminics with ethylenediamine structure (author"s transl)].	Hydrogen	50-52	cytochrome c oxidase subunit 8A	Homo sapiens	21-25
33219414-8	2021	We here report the near-complete NMR backbone and sidechain resonance assignment (1H,13C,15N) of isolated nsp7 from SARS-CoV-2 in solution.	Hydrogen	82-84	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	106-110
33869168-10	2021	Molecular docking suggested that bilirubin entered the hydrophobic pocket pre-formed in 5-HT3A receptor with potential hydrogen bonding.	Hydrogen	119-127	5-hydroxytryptamine receptor 3A	Rattus norvegicus	88-94
33673467-0	2021	Influences of pH and EDTA Additive on the Structure of Ni Films Electrodeposited by Using Bubble Templates as Electrocatalysts for Hydrogen Evolution Reaction.	Hydrogen	131-139	phenylalanine hydroxylase	Homo sapiens	14-16
33673467-2	2021	The pH value and EDTA (ethylene diamine tetraacetic acid) additive are important factors for the structure control of electrodeposited metal films due to their adjustment of metal electrocrystallization and hydrogen evolution side reactions.	Hydrogen	207-215	phenylalanine hydroxylase	Homo sapiens	4-6
33673467-6	2021	When pH <= 7.7, hydrogen bubbles with large break-off diameter are easily adsorbed on film surface acting as porous structure templates, and the electroactive ion species, Ni2+ and Ni(NH3)n2+ complexes with low coordination number (n <= 3), possess high reduction overpotential, which is beneficial to forming protrusions and smaller particles.	Hydrogen	16-24	phenylalanine hydroxylase	Homo sapiens	5-7
33749235-0	2021	Enhanced Visible-Light-Driven Hydrogen Production through MOF/MOF Heterojunctions.	Hydrogen	30-38	lysine acetyltransferase 8	Homo sapiens	58-61
33749235-0	2021	Enhanced Visible-Light-Driven Hydrogen Production through MOF/MOF Heterojunctions.	Hydrogen	30-38	lysine acetyltransferase 8	Homo sapiens	62-65
7110118-0	1982	1H Fourier transform nuclear magnetic resonance relaxation rate studies on the interaction of acetanilide with purified isozymes of rabbit liver microsomal cytochrome P-450 and with cytochrome b5.	Hydrogen	0-2	cytochrome P-450	Oryctolagus cuniculus	156-172
33754285-0	2021	1H, 13C and 15N backbone resonance assignment of HIV-1 Gag (276-432) encompassing the C-terminal domain of the capsid protein, the spacer peptide 1 and the nucleocapsid protein.	Hydrogen	0-2	Pr55(Gag)	Human immunodeficiency virus 1	55-58
34046625-6	2021	According to the molecular docking analysis, compounds 11, 12 and 25 formed hydrogen bonds with the hinge region residues Lys857, Leu932 and Glu930 and hydrophobically came into contact with Leu983 at the catalytic site of JAK2, while compound 25 formed a hydrogen bond with Met769 at the hinge region, Lys721 near a glycine loop, and Asp831 at the activation loop of EGFR.	Hydrogen	256-264	Janus kinase 2	Homo sapiens	223-227
6462181-1	1982	It has been shown that the induction of earlier described system of potassium-dependent transport of hydrogen ions in mitochondria at low pH values of the incubation medium is inhibited by the inhibitors of mitochondria respiratory chain and ATPase.	Hydrogen	101-109	dynein axonemal heavy chain 8	Homo sapiens	242-248
33577335-6	2021	Further surface plasmon resonance (SPR) and hydrogen/deuterium exchange mass spectroscopic experiments confirm that the evaluated complex type N-glycan impedes the binding between IL-17A and its receptor IL-17RA.	Hydrogen	44-52	interleukin 17 receptor A	Homo sapiens	204-211
33656342-10	2021	The identified inhibitors have a molecular weight of approximately 500 Dal and are predicted to form primarily hydrogen bonds with CD73 in addition to hydrophobic stacking interactions.	Hydrogen	111-119	5'-nucleotidase ecto	Homo sapiens	131-135
33635645-0	2021	Mutagenesis, Hydrogen-Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase.	Hydrogen	13-21	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	120-149
6799200-5	1982	The resonance of HO-2 of the uronate residue of chondrosinate also shows anomalies that may arise from intra-residue hydrogen-bonding.	Hydrogen	117-125	heme oxygenase 2	Homo sapiens	17-21
33599654-2	2021	It is a monomer at high temperature (>323 K), but exists as an associated 12-membered macrocyclic trimer below 273 K. The PH/B FLP splits dihydrogen and serves as a metal-free hydrogenation catalyst.	Hydrogen	138-148	phenylalanine hydroxylase	Homo sapiens	122-124
33352382-5	2021	This method allowed to observe for the first time nitrate reduction up to pH 10 and 100 mM nitrate with dihydrogen, or up to pH 10 and 400 mM nitrate with acetate.	Hydrogen	104-114	phenylalanine hydroxylase	Homo sapiens	74-76
7322685-3	1981	The results indicate that an increase in breath hydrogen of greater than 10 ppm above base line values (delta ppm) by 120 minutes ("early increase" response) completely discriminates between biopsy-proven isolated lactase-insufficient and lactase-sufficient children.	Hydrogen	48-56	lactase	Homo sapiens	214-246
33564771-5	2021	Modeling analysis showed that the N501Y mutation would allow a potential aromatic ring-ring interaction and an additional hydrogen bond between the RBD and ACE2.	Hydrogen	122-130	angiotensin converting enzyme 2	Homo sapiens	156-160
33552834-4	2021	Our comprehensive structure analysis revealed that the natural substitution of amino acid residues Gln24, His34, Phe40, Leu79 and Met82 in the N-terminal alpha1 and alpha2 helices of the ACE2 receptor results in loss of crucial network of hydrogen-bonded and hydrophobic interactions with receptor binding domain of SARS-CoV-2 spike protein.	Hydrogen	239-247	angiotensin converting enzyme 2	Homo sapiens	187-191
33552834-4	2021	Our comprehensive structure analysis revealed that the natural substitution of amino acid residues Gln24, His34, Phe40, Leu79 and Met82 in the N-terminal alpha1 and alpha2 helices of the ACE2 receptor results in loss of crucial network of hydrogen-bonded and hydrophobic interactions with receptor binding domain of SARS-CoV-2 spike protein.	Hydrogen	239-247	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	327-332
33713702-8	2021	The compound interacts with Kir3.1 residues E141 and D173 through hydrogen bonds that proved critical for its inhibitory activity.	Hydrogen	66-74	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	28-34
7322685-5	1981	Breath hydrogen responses predicted assayed lactase activity in all patients with isolated lactase insufficiency, but were "falsely negative" in four of ten children whose lactase insufficiency was secondary to mucosal injury.	Hydrogen	7-15	lactase	Homo sapiens	44-51
33084150-5	2021	Molecular docking and molecular dynamics simulations explained why the chemical affinity of the new SARS-CoV-2 for hACE2 is much higher than in the case of SARS-CoV, revealing an intricate pattern of hydrogen bonds and hydrophobic interactions and estimating a free energy of binding, consistently much more negative in the case of SARS-CoV-2.	Hydrogen	200-208	angiotensin converting enzyme 2	Homo sapiens	115-120
7295640-0	1981	Hydrogen exchange rates in pancreatic trypsin inhibitor are not correlated to thermal stability in urea.	Hydrogen	0-8	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	38-55
33648410-4	2021	Similarly, the pharmacophore model for FFAR-4 (r2 = 0.92, q2 = 0.87) suggested that the presence of a hydrogen bond acceptor, one negative atom, two aromatic rings, and three hydrophobic groups plays a vital role in the binding of an inhibitor of FFAR-4.	Hydrogen	102-110	free fatty acid receptor 4	Homo sapiens	39-45
33387633-3	2021	The viscoelastic and protective properties of mucus are mainly produced by its mucin network, which is stabilized through electrostatic, hydrophobic and hydrogen bonding interactions.	Hydrogen	153-161	LOC100508689	Homo sapiens	79-84
28035500-0	1981	Population screening for the human adult lactase phenotypes with a multiple breaths version of the breath hydrogen test.	Hydrogen	106-114	lactase	Homo sapiens	41-48
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	90-98	angiotensin converting enzyme 2	Homo sapiens	159-164
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	90-98	angiotensin converting enzyme 2	Homo sapiens	159-164
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	90-98	angiotensin converting enzyme 2	Homo sapiens	159-164
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	185-193	angiotensin converting enzyme 2	Homo sapiens	159-164
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	185-193	angiotensin converting enzyme 2	Homo sapiens	159-164
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	185-193	angiotensin converting enzyme 2	Homo sapiens	159-164
33604973-3	2021	Then, a highly electronically insulating (0.11 mS cm-1 ) but highly Zn2+ ion conductive (80.2 mS cm-1 ) ZnF2 solid ion conductor with high Zn2+ transfer number (0.65) is constructed to isolate Zn metal from liquid electrolyte, which not only prohibits over 99.2% parasitic hydrogen evolution but also guides uniform Zn electrodeposition.	Hydrogen	273-281	zinc finger protein 2	Homo sapiens	104-108
33604973-4	2021	Precisely quantitated, the Zn@ZnF2 //Zn@ZnF2 cell only produces 0.02 mmol h-1 cm-2 of hydrogen (0.53% of the Zn//Zn cell).	Hydrogen	86-94	zinc finger protein 2	Homo sapiens	30-34
33604973-4	2021	Precisely quantitated, the Zn@ZnF2 //Zn@ZnF2 cell only produces 0.02 mmol h-1 cm-2 of hydrogen (0.53% of the Zn//Zn cell).	Hydrogen	86-94	zinc finger protein 2	Homo sapiens	40-44
33604973-5	2021	Encouragingly, a high-areal-capacity Zn@ZnF2 //MnO2 ( 3.2 mAh cm-2 ) full cell only produces maximum hydrogen flux of 0.06 mmol h-1 cm-2 (0.78% of the Zn//Zn cell) at the fully charging state.	Hydrogen	101-109	zinc finger protein 2	Homo sapiens	40-44
33646592-6	2021	A docking study revealed that the nitroxyethyl moiety of compound 5c may form hydrogen bonds with caspase-8 amino acid residues (SER256 and HIS255).	Hydrogen	78-86	caspase 8	Homo sapiens	98-107
33127052-8	2021	In absence of sacrificial agent, the NH4+ generation rate was66.35mumol.g-1h-1 for Cu2O/SnS2/SnO2, which is 1.9-fold higher than SnS2/SnO2.	Hydrogen	74-76	sodium voltage-gated channel alpha subunit 11	Homo sapiens	88-92
7221524-1	1981	To determine the sensitivity and specificity of breath hydrogen (H2) in detecting lactase deficiency, breath H2 collected by end-expiratory sampling and capillary blood glucose were measured after ingestion of 50 g of lactose in 36 patients with biopsy-proved isolated lactase deficiency, 42 with normal lactase activity and 6 with lactase deficiency secondary to mucosal lesions.	Hydrogen	65-67	lactase	Homo sapiens	82-89
33531790-11	2021	The docking analysis of CPT against the spike glycoprotein of SARS-CoV-2 showed hydrogen bonding with the amino acids at K466 with a bond distance of 2.56A  and K355 with a bond distance of 2.40A .	Hydrogen	80-88	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	40-45
33352382-8	2021	Denitrification with dihydrogen strongly increases the pH while with acetate the pH evolution depends on the initial pH.	Hydrogen	21-31	phenylalanine hydroxylase	Homo sapiens	55-57
33352382-8	2021	Denitrification with dihydrogen strongly increases the pH while with acetate the pH evolution depends on the initial pH.	Hydrogen	21-31	phenylalanine hydroxylase	Homo sapiens	81-83
33535500-0	2021	Comparative Study of the Photocatalytic Hydrogen Evolution over Cd1-xMnxS and CdS-beta-Mn3O4-MnOOH Photocatalysts under Visible Light.	Hydrogen	40-48	CD1c molecule	Homo sapiens	64-67
7221524-3	1981	The maximum increase in breath H2 concentration was more than 1.1 mumol/l (25 ppm) in all patients with isolated lactase deficiency, and less than 0.88 mumol/l (20 ppm) in 88% of patients with normal lactase activity; there were 5 false-positive results, attributed in one case to small bowel colonization and in another case to rapid transit after gastric surgery.	Hydrogen	31-33	lactase	Homo sapiens	113-120
33458732-0	2021	Quantitative analysis of the synergistic effect of Au nanoparticles on SnO2-rGO nanocomposites for room temperature hydrogen sensing.	Hydrogen	116-124	strawberry notch homolog 1	Homo sapiens	71-74
33352382-8	2021	Denitrification with dihydrogen strongly increases the pH while with acetate the pH evolution depends on the initial pH.	Hydrogen	21-31	phenylalanine hydroxylase	Homo sapiens	81-83
6788675-0	1981	Population screening for the human adult lactase phenotypes with a multiple breath version of the breath hydrogen test.	Hydrogen	105-113	lactase	Homo sapiens	41-48
33554856-3	2021	Here, using amide hydrogen-deuterium exchange mass spectrometry and molecular dynamics simulations, we have mapped the S:ACE2 interaction interface and uncovered long-range allosteric propagation of ACE2 binding to sites necessary for host-mediated proteolysis of S protein, critical for viral host entry.	Hydrogen	18-26	angiotensin converting enzyme 2	Homo sapiens	199-203
33347268-2	2021	Based on the unique pH-dependent disassembly/reassembly characteristic of apoFt, approximately 44.3 molecules of Ir(ppy)3 aggregated in the single cavity through both intermolecular pi-pi-stacking interactions and hydrogen bonds that efficiently restricted the intramolecular motions to trigger the AIECL effect.	Hydrogen	214-222	insulin receptor	Homo sapiens	113-121
18962841-2	1980	Values on the hydrogen scale are 1.06 V for A(3)Fe(II), 0.78 for A(2)B, 0.58 for A(2)C, 0.60 for AB(2), 0.39 for B(3), 0.39 for ABC, 0.21 for AC(2), 0.22 for B(2)C, 0.06 for BC(2), and -0.10 for C(3) at pH 11.0, 25 degrees , and ionic strength 0.2.	Hydrogen	14-22	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	128-131
33387885-9	2021	N-(4[(2E)-3-(4-dimetilaminophenyl)-1-(phenyl)-prop-2-en-1-one]) acetamide (PAAPA) chalcone had a better affinity with ACE2, with strong hydrogen interactions.	Hydrogen	136-144	angiotensin converting enzyme 2	Homo sapiens	118-122
33592857-9	2021	The molecular structure of GNRHR protein showed that p.Q174R mutation brought in a new stable hydrogen bond between position 174 and 215, may impede conformational mobility of the TMD4 and TMD5.	Hydrogen	94-102	gonadotropin releasing hormone receptor	Homo sapiens	27-32
33332093-7	2021	Furthermore, MEF could induce the abnormal expression of CYP3A65, GSTM1, p53, and DNMT1 genes in the liver due to the formation of hydrogen bonds between MEF and the protein residues of those genes.	Hydrogen	131-139	cytochrome P450, family 3, subfamily A, polypeptide 65	Danio rerio	57-64
33482814-0	2021	Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis.	Hydrogen	0-8	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	95-101
7412612-4	1980	At a CO concentration of 10%, the specific growth rate of the bacterium was 0.25 hr-1 (mu) and the coefficient for utilizing the energy of hydrogen oxidation was 19.6% (eta); at a CO concentration of 20%, mu was 0.18 hr-1 and eta was 14.2%; at a CO concentration of 30%, mu was 0.07 hr-1 and eta was 10.2%.	Hydrogen	139-147	endothelin receptor type A	Homo sapiens	169-172
33482814-0	2021	Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis.	Hydrogen	0-8	microRNA 124a-3	Mus musculus	102-112
33405914-2	2021	Different ligand configurations were observed for [Th(nPr-BTP)3]4+ complexes depending on the solvent"s ability to actively form hydrogen bonds.	Hydrogen	129-137	neuronal pentraxin receptor	Homo sapiens	54-57
33517493-4	2021	In the present study, we have highlighted the role of water molecules in hydrogen-bond optimization, in determining pKa values and protonation states of titratable residues in JH2 domain of JAK2 apo protein.	Hydrogen	73-81	Janus kinase 2	Homo sapiens	190-194
33382255-0	2021	Correction to "Observation of Exceptionally Strong Binding of Molecular Hydrogen in a Porous Material: Formation of an eta2-H2 Complex in a Cu-Exchanged ZSM-5 Zeolite".	Hydrogen	72-80	DNA polymerase iota	Homo sapiens	119-123
7412612-4	1980	At a CO concentration of 10%, the specific growth rate of the bacterium was 0.25 hr-1 (mu) and the coefficient for utilizing the energy of hydrogen oxidation was 19.6% (eta); at a CO concentration of 20%, mu was 0.18 hr-1 and eta was 14.2%; at a CO concentration of 30%, mu was 0.07 hr-1 and eta was 10.2%.	Hydrogen	139-147	endothelin receptor type A	Homo sapiens	226-229
33346259-5	2021	Functionalization of the NiO QDs electrodes with either heterogeneous Pt or the molecular nickel bis(diphosphine) complex (1) as the hydrogen evolving catalysts (HECs) yields active photocathodes capable of promoting hydrogen evolution upon photoirradiation (maximum photocurrent densities of -16(+-2) and -20(+-1) muA cm-2 for Pt and 1 HECs, respectively, at 0 V vs. NHE, 70-80% faradaic efficiency, maximum IPCE of ca.	Hydrogen	217-225	solute carrier family 9 member C1	Homo sapiens	368-371
7412612-4	1980	At a CO concentration of 10%, the specific growth rate of the bacterium was 0.25 hr-1 (mu) and the coefficient for utilizing the energy of hydrogen oxidation was 19.6% (eta); at a CO concentration of 20%, mu was 0.18 hr-1 and eta was 14.2%; at a CO concentration of 30%, mu was 0.07 hr-1 and eta was 10.2%.	Hydrogen	139-147	endothelin receptor type A	Homo sapiens	226-229
33347888-12	2021	We propose that the differences are due to a network of hydrogen bonds that gets disrupted when Cdc42 is bound to GDP, a disruption that does not exist in other Rho GTP-ases.	Hydrogen	56-64	cell division cycle 42	Homo sapiens	96-101
6158016-1	1980	The effect of brain neovascularization by omental transposition on somatosensory evoked potentials and on regional cerebral blood flow (rCBF) measured by hydrogen clearance was evaluated in rabbits exposed to experimental ischemia after occlusion of the middle cerebral artery (MCA).	Hydrogen	154-162	CCAAT/enhancer binding protein zeta	Rattus norvegicus	136-140
33469055-9	2021	These changes resulted in extending the distance and losing the hydrogen bonds between CD155 and CD226, thus weakening CD155/CD226 binding activity.	Hydrogen	64-72	CD226 molecule	Homo sapiens	97-102
33469055-9	2021	These changes resulted in extending the distance and losing the hydrogen bonds between CD155 and CD226, thus weakening CD155/CD226 binding activity.	Hydrogen	64-72	CD226 molecule	Homo sapiens	125-130
33325709-4	2021	Experiments conducted under varying bias potential, pH, illumination intensity, and scan rate reveal two distinct mechanisms of photoelectrochemical hydrogen production.	Hydrogen	149-157	phenylalanine hydroxylase	Homo sapiens	52-54
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	Hydrogen	8-10	galanin and GMAP prepropeptide	Bos taurus	65-68
33020904-4	2021	Molecular dynamics simulations support the inference that crowding reduces binding interaction between actin filaments and fascin or the calphonin homology 1 domain of alpha-actinin evidenced by interaction energy and hydrogen bonding analysis.	Hydrogen	218-226	fascin actin-bundling protein 1	Homo sapiens	123-129
33189750-4	2021	The structure of COS-g-Lin1-3 were characterized by UV-vis, FT-IR, 1H NMR and elemental analysis in order to show the COS-g-Lin1-3 successfully synthesized.	Hydrogen	67-69	CD2 cytoplasmic tail binding protein 2	Homo sapiens	23-29
33284343-0	2021	Hydrogen Deuterium Exchange Mass Spectrometry identifies the dominant paratope in CD20 antigen binding to the NCD1.2 monoclonal antibody.	Hydrogen	0-8	membrane spanning 4-domains A1	Canis lupus familiaris	82-86
33284343-6	2021	Using light chain-7 as a reference sequence, hydrogen-deuterium exchange mass spectrometry was used to identify the dominant CDR region implicated in CD20 antigen binding.	Hydrogen	45-53	membrane spanning 4-domains A1	Canis lupus familiaris	150-154
33189750-4	2021	The structure of COS-g-Lin1-3 were characterized by UV-vis, FT-IR, 1H NMR and elemental analysis in order to show the COS-g-Lin1-3 successfully synthesized.	Hydrogen	67-69	CD2 cytoplasmic tail binding protein 2	Homo sapiens	23-27
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	Hydrogen	8-10	galanin and GMAP prepropeptide	Bos taurus	88-91
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	Hydrogen	8-10	galanin and GMAP prepropeptide	Bos taurus	88-91
7378351-3	1980	Specifically, the assignments of the 1H resonances of the two diastereoisomers of d-ApA (designated as 1 and 2) were reaffirmed by comparing with the unmodified, parent d-ApA.	Hydrogen	37-39	prostaglandin D2 receptor	Homo sapiens	100-110
32444370-18	2021	imaging window, TTN (mean [95% confidence interval]) remained high in all key organs: Liver (1h p.i.	Hydrogen	93-95	titin	Homo sapiens	16-19
33385956-6	2021	Molecular modeling studies of 22d docked inside the Sph binding pocket of both SphK1 and SphK2 indicate essential hydrogen bond between the 2-(hydroxymethyl)pyrrolidine head to interact with aspartic acid and serine residues near the ATP binding pocket, which provide the basis for dual inhibition.	Hydrogen	114-122	sphingosine kinase 2	Homo sapiens	89-94
33397109-3	2021	These collision adducts undergo a nonstatistical unimolecular decomposition through atomic hydrogen elimination to at least the cyclic 1-vinyl-cyclopropene (p5/p26), 1-methyl-3-methylenecyclopropene (p28), and 1,2-bis(methylene)cyclopropane (p29) in overall exoergic reactions.	Hydrogen	91-99	SYF2 pre-mRNA splicing factor	Homo sapiens	242-245
32590694-13	2021	The present study showed that hydrogen gas therapy increased the 7-day survival rate, improved cognitive function, increased the mitochondrial function (MMP, ATP level, complex I activity) and expression of mitochondrial biogenesis parameters (PGC-1alpha, NRF2, Tfam).	Hydrogen	30-38	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	244-254
6893010-4	1980	N-Methylpyridinium cations bearing 3-CONH2, 3-CONHCH3, 3-COCH3, 3-CO2- or 3-CN substituents are readily oxidized at C-6 and this suggests an important hydrogen-bonding interaction between an enzyme donor and the C-3 carbonyl substituent.	Hydrogen	151-159	complement C6	Homo sapiens	116-119
32590694-13	2021	The present study showed that hydrogen gas therapy increased the 7-day survival rate, improved cognitive function, increased the mitochondrial function (MMP, ATP level, complex I activity) and expression of mitochondrial biogenesis parameters (PGC-1alpha, NRF2, Tfam).	Hydrogen	30-38	transcription factor A, mitochondrial	Mus musculus	262-266
32590694-15	2021	Therefore, these results indicate that hydrogen gas alleviates sepsis-induced brain injury in mice by improving mitochondrial biogenesis through the activation of PGC-1alpha.	Hydrogen	39-47	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	163-173
33420032-3	2021	Here we report an experimental structure of drug-bound EmrE in phospholipid bilayers, determined using 19F and 1H solid-state NMR and a fluorinated substrate, tetra(4-fluorophenyl) phosphonium (F4-TPP+).	Hydrogen	111-113	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	55-59
33532188-5	2021	The half maximal inhibitory concentrations of 1H against UT-B in mouse, rat, and human erythrocyte were 1.60, 0.64, and 0.13 mumol/L, respectively.	Hydrogen	46-48	solute carrier family 14 (urea transporter), member 1	Mus musculus	57-61
7255197-2	1980	The method involves the use of kinetic secondary alpha-hydrogen isotope effects which are expected to accompany sp2 to sp3 rehybridization of C-6 of the pyrimidine ring if they occur prior to or at the rate determining step.	Hydrogen	55-63	complement C6	Homo sapiens	142-145
365254-3	1978	The novel method described depends on the measurement of changes in chemical shift of the 1H-NMR choline head-group signals as Pr3+ is transported from outside to inside the vesicles.	Hydrogen	90-92	proteinase 3	Homo sapiens	127-130
33285409-4	2021	The molecular dynamic simulation and the isothermal titration calorimetric (ITC) assay further demonstrated the potential of cAIMP isomers with 2"-5" phosphate to form the hydrogen binding with R232 and R238 residues of hSTING in an entropically driven manner compared to cGAMP isomers.	Hydrogen	172-180	stimulator of interferon response cGAMP interactor 1	Homo sapiens	220-226
28747-0	1978	Nuclear magnetic resonance measurement of hydrogen exchange kinetics of single protons in basic pancreatic trypsin inhibitor.	Hydrogen	42-50	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	107-124
33390512-8	2021	Molecular modeling simulation of the designed compounds revealed that they were well fitted into CDK2 active site and their complexes were stabilized through the essential hydrogen bonding.	Hydrogen	172-180	cyclin dependent kinase 2	Homo sapiens	97-101
694230-6	1978	C1A was not dose-dependent in the HF or LF groups (mean 177.9 ml/min and 168.4 ml/min) but was dose-dependent in the HS group (mean 74.6 ml/min) which differed significantly from the LS group (mean 113.4 ml/min).	Hydrogen	117-119	endogenous retrovirus group K member 1	Homo sapiens	0-3
33125650-1	2021	Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is, nowadays, an increasingly important technique in studying protein conformation and dynamics.	Hydrogen	0-8	highly divergent homeobox	Homo sapiens	47-50
33012565-2	2021	BACKGROUND AND OBJECTIVES: dRTA is a genetic or acquired rare disease, characterized by an unability to excrete hydrogens (H+) into urine, hypobicarbonatemia, hyperchloremia, and frequently hypercalciuria and hypokalaemia.	Hydrogen	112-121	rta	Drosophila melanogaster	27-31
24708-1	1978	The proportions of the main components present in gentamicin sulphate complex, gentamicins C1, C1a and C2, can be monitored by 1H nuclear magnetic resonance (nmr) spectrometry.	Hydrogen	127-129	endogenous retrovirus group K member 1	Homo sapiens	95-98
33285471-14	2021	The molecular simulation study showed that ST interacted with the ligand binding domain of liver X receptor beta (LXRbeta), a known binding receptor of ST, through multiple hydrogen bonding.	Hydrogen	173-181	nuclear receptor subfamily 1 group H member 3	Homo sapiens	114-121
23288-1	1977	1H NMR spectroscopy at 100 MHz was used to determine the first-order rate constants for the 1H-2H exchange of the H-2 histidine resonances of RNase-A in 2H2O at 35 degrees C and pH meter readings of 7, 9, 10 and 10.5.	Hydrogen	0-2	ribonuclease A family member 1, pancreatic	Homo sapiens	142-149
32484077-16	2021	We optimized the 2 h cleavage reaction times for both wt-hMC4R-TM2 and m-hMC4R-TM2 depending on the purity based on mass spectra and 1H-15N HSQC spectra and the yield after final purification.	Hydrogen	133-135	tropomyosin 1, alpha	Mus musculus	79-82
32484077-17	2021	The 1D 1H-15N CP (Cross polarization) solid-state NMR spectra suggest that the wt/m-hMC4R-TM2 undergo rotational diffusion around a perpendicular axis along the bilayer normal.	Hydrogen	7-9	tropomyosin 1, alpha	Mus musculus	90-93
23288-1	1977	1H NMR spectroscopy at 100 MHz was used to determine the first-order rate constants for the 1H-2H exchange of the H-2 histidine resonances of RNase-A in 2H2O at 35 degrees C and pH meter readings of 7, 9, 10 and 10.5.	Hydrogen	92-94	ribonuclease A family member 1, pancreatic	Homo sapiens	142-149
23288-7	1977	1H NMR spectra of S-protein and S-peptide, and of material partially deuterated at the C-2 positions of the histidine residues confirm the reassignment of the histidine resonances of RNase-A [Bradbury, J. H. &amp; Teh, J. S. (1975) Chem.	Hydrogen	0-2	ribonuclease A family member 1, pancreatic	Homo sapiens	183-190
301863-2	1977	HD1 cells are more resistant than H4 to ionizing radiation, actinomycin D and cordycepin.	Hydrogen	34-36	histone deacetylase 1	Rattus norvegicus	0-3
33295347-4	2020	The results showed that the RBD of 2019-nCov bound much stronger with ACE2 than that of SARS-CoV due to a better organized hydrogen bond network between the former pair with most of the residues at the contact interface sharing the responsibility to hold the pair tightly.	Hydrogen	123-131	angiotensin converting enzyme 2	Homo sapiens	70-74
193566-2	1977	ESR analysis revealed the induction of hydrogen adduct free radicals at C-6 position of thymine, only with those furocoumarin derivatives which show a skin-photosensitizing ability.	Hydrogen	39-47	complement C6	Homo sapiens	72-75
33470198-8	2020	The amide 1H dispersion of 3.6 ppm (6.6-10.2 ppm) in the 15N-HSQC-spectra of instantly refolded NEP-N confirmed the folded state.	Hydrogen	10-12	nephrocan, pseudogene	Homo sapiens	96-101
576136-1	1977	Intestinal lactase activity was assessed indirectly in 156 American Indians by measuring breath hydrogen after an oral lactose load.	Hydrogen	96-104	lactase	Homo sapiens	11-18
33319692-0	2022	A Combined approach of Pharmacophore Modeling, QSAR Study, Molecular Docking and in silico ADME/Tox prediction of 4-Arylthio & 4- Aryloxy-3- Iodopyridine-2(1H)-one analogs to identify potential Reverse Transcriptase inhibitor: Anti-HIV agents.	Hydrogen	156-158	thymocyte selection associated high mobility group box	Homo sapiens	96-99
4369451-0	1974	1H nuclear magnetic resonance studies of thyrotropin releasing factor (TRF).	Hydrogen	0-2	thyrotropin releasing hormone	Homo sapiens	41-69
33201708-0	2020	Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions.	Hydrogen	100-108	transient receptor potential cation channel subfamily V member 4	Homo sapiens	54-59
4369451-0	1974	1H nuclear magnetic resonance studies of thyrotropin releasing factor (TRF).	Hydrogen	0-2	thyrotropin releasing hormone	Homo sapiens	71-74
4549968-0	1974	Analytical application of the stereospecific hydrogen exchange reaction between (R)-carnitine and water, catalyzed by (R)-carnitine dehydrogenase and alpha-lipoamide dehydrogenase (diaphorase).	Hydrogen	45-53	dihydrolipoamide dehydrogenase	Homo sapiens	181-191
33216521-1	2020	The employment of hybrid perovskite MAPbX3 (MA = CH3NH3+, X = Br or I) as photocatalysts in a photocatalytic hydrogen evolution reaction represents a promising approach to store solar energy.	Hydrogen	109-117	PBX homeobox 3	Homo sapiens	36-42
33335340-4	2020	Using two-dimensional infrared spectroscopy, we show that hyaluronan chains become connected by hydrogen bonds when the pH is changed from 7.0 to 2.5 and that the bond density at pH 2.5 is independent of temperature.	Hydrogen	96-104	phenylalanine hydroxylase	Homo sapiens	120-122
33335340-5	2020	Temperature-dependent rheology measurements show that because of this hydrogen bonding the stress relaxation at pH 2.5 is strongly slowed down in comparison to pH 7.0, consistent with the sticky reptation model of associative polymers.	Hydrogen	70-78	phenylalanine hydroxylase	Homo sapiens	112-114
33335340-5	2020	Temperature-dependent rheology measurements show that because of this hydrogen bonding the stress relaxation at pH 2.5 is strongly slowed down in comparison to pH 7.0, consistent with the sticky reptation model of associative polymers.	Hydrogen	70-78	phenylalanine hydroxylase	Homo sapiens	160-162
33211784-6	2020	The acid catalyzed isomerization of MVK-oxide proceeds by a double hydrogen-bonded interaction followed by a concerted H-atom transfer via submerged barriers to produce HPBD and regenerate formic acid.	Hydrogen	67-75	mevalonate kinase	Homo sapiens	36-39
4753200-0	1973	The stereospecificity of D-glucose-6-phosphate: 1L-myo-inositol-1-phosphate cycloaldolase on the hydrogen atoms at C-6.	Hydrogen	97-105	complement C6	Homo sapiens	115-118
33207866-8	2020	In-depth investigation reveals that the beta-sheets formed between Leu12-His18 and Leu27-Gly33 enhance the peptide-peptide interactions that are broken by norepinephrine, which itself interacts with the peptides via hydrogen bonding, hydrophobic, and aromatic stacking interactions, preferentially with the C-terminal residues of hIAPP.	Hydrogen	216-224	islet amyloid polypeptide	Homo sapiens	330-335
5799639-0	1969	Location of hydrogen transfer steps in the mechanism of reduction of L-amino acid oxidase.	Hydrogen	12-20	interleukin 4 induced 1	Homo sapiens	69-89
32898834-6	2020	In our findings, the highest-ranked 4 feature pharmacophore model possessed one hydrogen bond acceptor, one hydrophobic feature and two ring features (AHRR).	Hydrogen	80-88	aryl hydrocarbon receptor repressor	Homo sapiens	151-155
4387233-8	1968	It is suggested that glutathione reductase activity can occur only when accompanied by an oxidative reaction, and that this close link between the two reactions represents a mechanism of electron transport which transfers hydrogen to molecular O(2).	Hydrogen	222-230	glutathione-disulfide reductase	Homo sapiens	21-42
33166654-11	2020	The three-finger-like structure is stabilized by a network of hydrogen bonds between residues 331-361 and 379-387, thus forming a molecular surface unique to Smad7.	Hydrogen	62-70	SMAD family member 7	Mus musculus	158-163
33320594-5	2020	The CS-based ionic network and PEGDA-based covalent network as well as the hydrogen bonds between them jointly induce excellent mechanical properties, which can be regulated by changing the PEGDA/CS content and ionic cross-linking time.	Hydrogen	75-83	citrate synthase	Homo sapiens	190-198
13584424-0	1958	Catalysis of hydrogen transfer between pyridine nucleotides by 3 alpha-hydroxysteroid dehydrogenase.	Hydrogen	13-21	aldo-keto reductase family 1 member C3	Homo sapiens	63-99
33287208-1	2020	Potential of hydrogen (pH) is one of the most relevant parameters characterizing aqueous solutions.	Hydrogen	13-21	phenylalanine hydroxylase	Homo sapiens	23-25
33490624-5	2021	Methods: This was a randomized, double-blind, crossover placebo-controlled trial to study the effect of lactase tablets on symptoms and hydrogen breath levels in adults with lactose intolerance, confirmed by Lactose HBT.	Hydrogen	136-144	lactase	Homo sapiens	104-111
33490624-9	2021	Clinical symptoms, mean clinical score (P < 0.05), and mean hydrogen breath levels (P < 0.05) were improved when the patients were given lactase.	Hydrogen	60-68	lactase	Homo sapiens	137-144
33490624-10	2021	Reduction in cumulative hydrogen breath level over 180 min was 55% when patients received lactase compared to placebo.	Hydrogen	24-32	lactase	Homo sapiens	90-97
33894546-4	2021	The covalent imine bonds between originally hydrophilic PAH and hydrophobic BA are dynamic in that their formation and breakage is a function of solution pH, confirmed by 1H NMR and dynamic interfacial tension measurement.	Hydrogen	171-173	phenylalanine hydroxylase	Homo sapiens	154-156
33181018-0	2020	Hydrogen-Deuterium Exchange within Adenosine Deaminase, a TIM Barrel Hydrolase, Identifies Networks for Thermal Activation of Catalysis.	Hydrogen	0-8	adenosine deaminase	Mus musculus	35-54
33276663-3	2020	On the other hand, an anhydride CA4 formed a dimer by hydrogen bonds between adjacent molecules in the crystal, which were aggregated by van der Waals forces and placed in parallel planar cyclic sites.	Hydrogen	54-62	carbonic anhydrase 4	Homo sapiens	32-35
32947081-6	2020	The aptamer APT12TM can be folded into a stable B-DNA structure, and its strong interaction with LCN 1, including hydrogen bonding and hydrophobic interactions, is an important factor for targeted recognition and high-affinity binding.	Hydrogen	114-122	lipocalin 1	Homo sapiens	97-102
33681755-4	2021	Here, using Molecular Dynamics simulations (MD) and Monte Carlo (MC) sampling, we show that the N501 mutation enhanced the electrostatic interactions due to the formation of a strong hydrogen bond between SARS-CoV-2-T500 and ACE2-D355 near the mutation site.	Hydrogen	183-191	angiotensin converting enzyme 2	Homo sapiens	225-229
33073977-1	2020	A dynamic frequency shift (DFS) in the 1H NMR resonance of the HD unit of the deuterium-labeled dihydrogen complex [Ru(D)(eta2-HD)(P3P3iPr)][BPh4] [P3P3iPr = P(CH2CH2CH2PiPr2)3] has been observed and analyzed.	Hydrogen	96-106	DNA polymerase iota	Homo sapiens	122-126
32736114-9	2020	In silico docking methods elucidate the contribution of hydrogen bonds and hydrophobic contacts towards the binding of 2"-OH-PCB61 and 2"-OH-PCB65 with CES1 and CES2.	Hydrogen	56-64	carboxylesterase 1	Homo sapiens	152-156
34036731-4	2021	Compound B4 was identified as a selective AChE inhibitor (IC 50 = 8.93 muM), which was nicely fallen into Tc AChE via hydrogen interactions between delta-pyridylsultone scaffold with Asp72, Ser122, Phe288, Phe290 and Trp84.	Hydrogen	118-126	acetylcholinesterase	Mus musculus	42-46
34036731-4	2021	Compound B4 was identified as a selective AChE inhibitor (IC 50 = 8.93 muM), which was nicely fallen into Tc AChE via hydrogen interactions between delta-pyridylsultone scaffold with Asp72, Ser122, Phe288, Phe290 and Trp84.	Hydrogen	118-126	acetylcholinesterase	Mus musculus	109-113
33950203-4	2021	The RNA engages in hydrogen-bonded contacts and stacking interactions with the PIN and ZnF domains simultaneously.	Hydrogen	19-27	zinc finger protein 763	Homo sapiens	87-90
32424143-5	2020	LOXL1-D515 interacted with BAG2-K186 through a hydrogen bond, and its lysyl oxidase activity prevented BAG2 degradation by competing with K186 ubiquitylation.	Hydrogen	47-55	lysyl oxidase like 1	Homo sapiens	0-5
34015629-7	2021	Moreover, these alterations were related to the abnormal transcriptional levels of peroxisome proliferator-activated receptor alpha (PPAR-alpha) and liver x receptor alpha (LXR-alpha), which were predicted to bind to tebuconazole via hydrogen bonding interactions.	Hydrogen	234-242	nuclear receptor subfamily 1 group H member 3	Homo sapiens	173-182
33105999-6	2020	Adsorption onto cellulose stabilizes in this configuration, with the help of a large number of hydrogen bonds developed between cellulose and the three receptor-binding domains of the glycoprotein spike.	Hydrogen	95-103	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	197-202
33092043-0	2020	Sodium Hydrogen Exchanger Regulatory Factor-1 (NHERF1) Regulates Fetal Membrane Inflammation.	Hydrogen	7-15	SLC9A3 regulator 1	Homo sapiens	47-53
33939417-6	2021	A new crystal structure of ADAR2 bound to duplex RNA bearing a cytidine analog revealed a close contact between E488, stabilized by an additional hydrogen bond and altered charge distribution when compared to cytidine.	Hydrogen	146-154	adenosine deaminase RNA specific B1	Homo sapiens	27-32
33066044-7	2020	Molecular dynamics simulation results showed that A14 formed a stable complex with 1LPB protein via hydrogen bonds with important residues in regulating enzyme activity (Ser152 and Phe77).	Hydrogen	100-108	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	50-53
32236803-0	2020	1H, 13C, 15N chemical shift assignments of SHP2 SH2 domains in complex with PD-1 immune-tyrosine motifs.	Hydrogen	0-2	programmed cell death 1	Homo sapiens	76-80
33994655-6	2021	The MD simulations of ligand-free, Rutin DAB10-bound, and Swertiapuniside-bound ACE2-Spike complex revealed abrogation of the hydrogen bonding network between the two proteins.	Hydrogen	126-134	angiotensin converting enzyme 2	Homo sapiens	80-84
33994655-6	2021	The MD simulations of ligand-free, Rutin DAB10-bound, and Swertiapuniside-bound ACE2-Spike complex revealed abrogation of the hydrogen bonding network between the two proteins.	Hydrogen	126-134	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	85-90
33955998-4	2021	Molecular docking with T1R1/T1R3 receptors showed that the interaction forces were mainly hydrogen bonds, electrostatic interaction and van der Waals force.	Hydrogen	90-98	taste 1 receptor member 1	Homo sapiens	23-27
33195009-6	2020	The chemical structures of the synthesized EP and CP were confirmed by Fourier transform infrared (FTIR), nuclear magnetic resonance (1H, 13C, 31P NMR), and single crystal XRD (only in the case of EP).	Hydrogen	134-136	epiregulin	Homo sapiens	43-52
33195009-6	2020	The chemical structures of the synthesized EP and CP were confirmed by Fourier transform infrared (FTIR), nuclear magnetic resonance (1H, 13C, 31P NMR), and single crystal XRD (only in the case of EP).	Hydrogen	134-136	epiregulin	Homo sapiens	43-45
32895690-6	2020	Electropositive CSH-AuNCs could be bound to the main nucleating region of amylin via hydrogen bonding and endowed the nanocomplex with more positive net charges (amylin monomer with a positive +26.23 +- 0.80 mV zeta potential), which would inhibit the misfolding and aggregation of amylin via electrostatic repulsion and steric hindrance.	Hydrogen	85-93	islet amyloid polypeptide	Homo sapiens	74-80
32666189-5	2020	All the contact residues contributing to hydrogen bonds are located in VH-CDR2 or its neighboring region, and two of them were mutants of the closest germline sequence.	Hydrogen	41-49	cerebellar degeneration related protein 2	Homo sapiens	74-78
32827996-6	2020	The combination of solvent-suppressed 1H detected PISEMO and the use of a strip shield-solenoid coil probe configuration provides a two-fold sensitivity enhancement in both the crystal sample and Pf1 coat protein sample compared to the 15N direct detection method.	Hydrogen	38-40	PHD finger protein 12	Homo sapiens	196-199
32838564-6	2022	Disperse black 9 shows more strong binding by occupying a groove and forming one hydrogen bond with Tyr465 of acetyl choline esterase enzyme while Disperse blue-124 shows surface binding without forming any hydrogen bond.	Hydrogen	81-89	Acetylcholine esterase	Drosophila melanogaster	110-133
32811353-5	2021	However, although part of a flexible loop, ETGE itself is firmly attached to the DPP III surface by strong hydrogen bonds.	Hydrogen	107-115	dipeptidyl peptidase 3	Homo sapiens	81-88
32823913-2	2020	The evaluation of their cytotoxic activities against two human cancer cell lines (SKOV-3 and HCT116) using the MTT assay in vitro revealed a distinctive structure activity relationship (SAR) associated with the intramolecular hydrogen bonding of the amide moiety at C-23.	Hydrogen	226-234	nucleolin	Homo sapiens	266-270
32773036-2	2020	Hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS) was used to map the membrane and NDP52 binding sites of the ULK1 complex to unique regions of the coiled coil of the FIP200 subunit.	Hydrogen	0-8	calcium binding and coiled-coil domain 2	Homo sapiens	99-104
32773036-2	2020	Hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS) was used to map the membrane and NDP52 binding sites of the ULK1 complex to unique regions of the coiled coil of the FIP200 subunit.	Hydrogen	0-8	unc-51 like autophagy activating kinase 1	Homo sapiens	126-130
32270438-5	2020	Molecular docking of the drug-polymer conjugate with ocular surface mucin (MUC-1) suggested that amino acid residues Arg1095, Asn1091, and Gln1070 of mucin are involved in hydrogen bonding with carboxyl residues in the polymer structure.	Hydrogen	172-180	mucin 1, cell surface associated	Homo sapiens	75-80
32270438-5	2020	Molecular docking of the drug-polymer conjugate with ocular surface mucin (MUC-1) suggested that amino acid residues Arg1095, Asn1091, and Gln1070 of mucin are involved in hydrogen bonding with carboxyl residues in the polymer structure.	Hydrogen	172-180	LOC100508689	Homo sapiens	150-155
32658222-7	2020	A SAPT analysis revealed that the complexes BLiR and BNaR have larger electrostatic contributions to De than do the hydrogen- and halogen-bonded counterparts BHCl and BClF.	Hydrogen	116-124	FRAS1 related extracellular matrix 1	Homo sapiens	53-57
32558829-1	2020	An unprecedented nickel-catalyzed hydroarylative and hydroalkenylative cyclization of unsymmetrically substituted 1,6-dienes with organoboronic acid was developed by using MeOH as the hydrogen source and employing commercially available Ni(eta2-1,5-cyclooctadiene)2 as the catalyst.	Hydrogen	184-192	DNA polymerase iota	Homo sapiens	240-244
32619162-7	2021	p28 interacted with all the three viral proteins and the host ACE-2 receptor by forming several electrostatic and hydrogen bonds with the S-protein, 3CLpro, and PLpro.	Hydrogen	114-122	angiotensin converting enzyme 2	Homo sapiens	62-67
32619162-7	2021	p28 interacted with all the three viral proteins and the host ACE-2 receptor by forming several electrostatic and hydrogen bonds with the S-protein, 3CLpro, and PLpro.	Hydrogen	114-122	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	161-166
32371117-6	2020	Docking studies, confirmed that, the sulfonamide SO2 oxygen was involved in a hydrogen bond with Lys162 and Lys122 in AURKA and AURKB, respectively, whereas, the sulfonamide NH could catch hydrogen bond interaction with the surrounding amino acid residues Lys141, Glu260, and Asn261 in AURKA and Lys101, Glu177, and Asp234 in AURKB.	Hydrogen	78-86	aurora kinase A	Homo sapiens	118-123
32371117-6	2020	Docking studies, confirmed that, the sulfonamide SO2 oxygen was involved in a hydrogen bond with Lys162 and Lys122 in AURKA and AURKB, respectively, whereas, the sulfonamide NH could catch hydrogen bond interaction with the surrounding amino acid residues Lys141, Glu260, and Asn261 in AURKA and Lys101, Glu177, and Asp234 in AURKB.	Hydrogen	189-197	aurora kinase A	Homo sapiens	286-291
32371117-7	2020	Furthermore, N1 nitrogen of the quinoline scaffold formed an essential hydrogen bond with the hinge region key amino acids Ala213 and Ala173 in AURKA and AURKB, respectively.	Hydrogen	71-79	aurora kinase A	Homo sapiens	144-149
32350570-15	2020	Hydrogen increased Nrf2 expression and inhibited the SAE-induced expression of NLRP3, caspase-1, cytokines IL-1beta and IL-18, neuronal apoptosis, and mitochondrial dysfunction in WT mice but not Nrf2 KO mice.	Hydrogen	0-8	caspase 1	Mus musculus	86-95
32350570-15	2020	Hydrogen increased Nrf2 expression and inhibited the SAE-induced expression of NLRP3, caspase-1, cytokines IL-1beta and IL-18, neuronal apoptosis, and mitochondrial dysfunction in WT mice but not Nrf2 KO mice.	Hydrogen	0-8	interleukin 18	Mus musculus	120-125
32361189-9	2020	Importantly, hydrogen treatment prevented mitochondrial depolarization, cytochrome c release, and activity of caspase-3, caspase-9, and PARP.	Hydrogen	13-21	caspase 9	Mus musculus	121-130
32361189-10	2020	Moreover, the decreased expression of Bcl-xl and Bcl-2 and the increased expression of Bax protein were also blocked by hydrogen treatment.	Hydrogen	120-128	BCL2-like 1	Mus musculus	38-44
32265369-2	2020	However, whether this relaxation is associated with the activity of sensory calcitonin gene-related peptide (CGRP) nerves and whether this is modulated by hydrogen protons (H), facilitating the release of CGRP from sensory CGRPergic nerve terminals in the MCA, remains unclear.	Hydrogen	155-163	calcitonin-related polypeptide alpha	Rattus norvegicus	205-209
32470284-3	2020	The hydrogen bonds network which are constructed by the uncoordinated anionic tetrazolium, and the coordinated and free water molecules endowed this Eu-MOF with the highest proton conductivity of 4.45x10-2 S/cm at 373 K and 93% RH.	Hydrogen	4-12	lysine acetyltransferase 8	Homo sapiens	152-155
32672165-5	2020	By contrast, the Vf at 20 A/cm2 in the TJ microLEDs utilizing SAG is significantly reduced to be 3.24 to 3.31 V. Moreover, the Vf in the SAG TJ microLEDs is independent on sizes, suggesting that the hydrogen is effectively removed through the holes on top of the p-GaN surface by SAG.	Hydrogen	199-207	gigaxonin	Homo sapiens	265-268
32200349-2	2020	This boost in glycolytic flux supports proliferation, but also generates acid in the form of hydrogen ions that must be eliminated from the cytoplasm to maintain the alkaline intracellular pH (pHi) associated with transformation.	Hydrogen	93-101	glucose-6-phosphate isomerase	Homo sapiens	193-196
32167173-6	2020	Regarding contact modes, hydrophobic interactions contribute significantly in binding and additional hydrogen bonds were found between theaflavin and RdRp.	Hydrogen	101-109	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	150-154
33274246-7	2020	The structural investigations of the vaccine-TLR3 complex revealed the formation of fifteen interchain hydrogen bonds, thus validating its integrity and stability.	Hydrogen	103-111	toll like receptor 3	Homo sapiens	45-49
33203097-3	2020	By comparing the distance between the donor and the acceptor and these unique angles to the statistical preferences observed in the Protein Data Bank (PDB), we were able to identify a set of conserved geometries (15 for donor atoms and 7 for acceptor atoms) for hydrogen-mediated interactions in proteins.	Hydrogen	262-270	B cell scaffold protein with ankyrin repeats 1	Homo sapiens	145-149
33073977-1	2020	A dynamic frequency shift (DFS) in the 1H NMR resonance of the HD unit of the deuterium-labeled dihydrogen complex [Ru(D)(eta2-HD)(P3P3iPr)][BPh4] [P3P3iPr = P(CH2CH2CH2PiPr2)3] has been observed and analyzed.	Hydrogen	39-41	DNA polymerase iota	Homo sapiens	122-126
32604560-8	2020	In addition, the formation of crystal defects increased the oxygen transfer capacity of red mud from 1.75% to 2.25% at 15 vol.% hydrogen.	Hydrogen	128-136	adaptor related protein complex 5 subunit mu 1	Homo sapiens	92-95
31659777-8	2020	The results indicate that the delta22 component (with its direction approximately being co-planar with the formate anion and perpendicular to the C-H bond) is more sensitive to the adsorbate molecules inside the MOF channel due to the weak C-H   O hydrogen bonding or the ring current effect of benzene.	Hydrogen	248-256	lysine acetyltransferase 8	Homo sapiens	212-215
33254553-4	2020	In fact, in a single ACE2 molecule, 34 lysine residues are present in the extracellular portion, and at least one of these is co-involved in a fundamental hydrogen-bond interaction with the SARS-CoV-2 receptor binding domain (RBD).	Hydrogen	155-163	angiotensin converting enzyme 2	Homo sapiens	21-25
33194650-1	2020	ATP6V1s participate in the biological process of transporting hydrogen ions and are associated with various cancers in expression and clinicopathological features, while its role in kidney renal clear cell carcinoma is unknown.	Hydrogen	62-70	mitochondrially encoded ATP synthase 6	Homo sapiens	0-4
33066199-8	2020	The solvolysis liquefaction of CS could be classified into the mechanism of electrophilic substitution reaction attacked by the hydrogen cation.	Hydrogen	128-136	citrate synthase	Homo sapiens	31-33
33037300-5	2020	Recent crystal structures of the KDEL receptor in the apo and peptide bound state suggested that peptide binding drives the formation of a short-hydrogen bond that locks the KDEL sequence in the receptor and activates the receptor for COPI binding in the cytoplasm.	Hydrogen	145-153	KDEL endoplasmic reticulum protein retention receptor 1	Homo sapiens	33-46
32852951-5	2020	An increase in the rate of the HO2 self-reaction was also observed as a function of acetone (CH3C(O)CH3) concentration which is interpreted as a chaperone effect resulting from hydrogen-bond complexation between HO2 and CH3C(O)CH3.	Hydrogen	177-185	heme oxygenase 2	Homo sapiens	31-34
32852951-5	2020	An increase in the rate of the HO2 self-reaction was also observed as a function of acetone (CH3C(O)CH3) concentration which is interpreted as a chaperone effect resulting from hydrogen-bond complexation between HO2 and CH3C(O)CH3.	Hydrogen	177-185	heme oxygenase 2	Homo sapiens	212-215
32902991-3	2020	The n=1-3 entrance channel complexes show peaks around 2800 and 3000 cm-1 which indicates methane eta3 hydrogen coordination, while the n=4 complex has two peaks around 2800 cm-1 indicative of methane eta2 hydrogen coordination.	Hydrogen	206-214	DNA polymerase iota	Homo sapiens	201-205
32747741-3	2020	By dispersing Pd atoms onto Cu nanomaterials with different exposed facets, Cu(111) and Cu(100), we demonstrate in this work that while the hydrogen spillover from Pd to Cu is facet independent, the spillover hydrogenation only occurs on Pd1/Cu(100), where the hydrogen atoms spilled from Pd are readily utilized for the semi-hydrogenation of alkynes.	Hydrogen	140-148	programmed cell death 1	Homo sapiens	238-241
33029259-7	2020	Conclusions: Changes in Glu level measured by 1H-MRS were inversely correlated with those in EAAT2 and GluR2 protein levels following HI, and the results demonstrated that 1H-MRS can reflect the early changes of glutamatergic activity in vivo.	Hydrogen	172-174	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	103-108
33029472-4	2020	By measuring this distinct dumbbell shape together with the molecular orientation, a strategy is proposed to determine the conformation of the ferrocene moiety, herein on CaF2(111) surfaces, by using the protruding hydrogen atoms as markers.	Hydrogen	215-223	CCR4-NOT transcription complex subunit 8	Homo sapiens	171-175
32588927-2	2020	These pseudo-anomeric effects are apparent when electronegative CF 2 groups are placed at the C-2, C-4 and C-6 positions of the cyclohexane ring to render the C-3/5 axial hydrogens electropositive.	Hydrogen	171-180	complement C6	Homo sapiens	107-110
33886267-7	2021	In particular, HIV-1 Tat forms hydrogen bond interactions with side chains of hNET residues Y84, K88, and T544.	Hydrogen	31-39	tyrosine aminotransferase	Homo sapiens	21-24
33886267-8	2021	The favorable hydrogen bonding interactions of HIV-1 Tat with the hNET side chain residues Y84 and T544 have been validated by our subsequently performed DA uptake activity assays and site-directed mutagenesis, suggesting that the modeled HIV-1 Tat-hNET binding mode is reasonable.	Hydrogen	14-22	tyrosine aminotransferase	Homo sapiens	53-56
33886267-8	2021	The favorable hydrogen bonding interactions of HIV-1 Tat with the hNET side chain residues Y84 and T544 have been validated by our subsequently performed DA uptake activity assays and site-directed mutagenesis, suggesting that the modeled HIV-1 Tat-hNET binding mode is reasonable.	Hydrogen	14-22	tyrosine aminotransferase	Homo sapiens	245-248
32786538-5	2020	Two sets of star-shaped glycopolymers with on average 1, 3, 7, 8, and 15 arms were successfully synthesized and characterized via 1H-NMR, GPC and DLS.	Hydrogen	130-132	steroidogenic acute regulatory protein	Homo sapiens	12-16
33882231-4	2021	The reversible quadruple hydrogen-bonded UPy moieties provided a high binding constant and significantly improved the strength and toughness of the obtained mica paper.	Hydrogen	25-33	MHC class I polypeptide-related sequence A	Homo sapiens	157-161
32815956-2	2020	Using the first-principles calculation, we studied the effects of multi-hydrogen-tin/oxygen vacancy complex impurities on the electronic properties of the p-type monolayer SnO.	Hydrogen	72-80	strawberry notch homolog 1	Homo sapiens	172-175
32815956-9	2020	Our results indicated that limitation of hydrogen is necessary for the preparation of high-quality p-type two-dimensional SnO, as a small amount of hydrogen produces positive effect on p-type SnO; however, the higher concentration of hydrogen is destructive to the p-type character of monolayer SnO.	Hydrogen	41-49	strawberry notch homolog 1	Homo sapiens	122-125
32815956-9	2020	Our results indicated that limitation of hydrogen is necessary for the preparation of high-quality p-type two-dimensional SnO, as a small amount of hydrogen produces positive effect on p-type SnO; however, the higher concentration of hydrogen is destructive to the p-type character of monolayer SnO.	Hydrogen	148-156	strawberry notch homolog 1	Homo sapiens	122-125
32815956-9	2020	Our results indicated that limitation of hydrogen is necessary for the preparation of high-quality p-type two-dimensional SnO, as a small amount of hydrogen produces positive effect on p-type SnO; however, the higher concentration of hydrogen is destructive to the p-type character of monolayer SnO.	Hydrogen	148-156	strawberry notch homolog 1	Homo sapiens	192-195
32815956-9	2020	Our results indicated that limitation of hydrogen is necessary for the preparation of high-quality p-type two-dimensional SnO, as a small amount of hydrogen produces positive effect on p-type SnO; however, the higher concentration of hydrogen is destructive to the p-type character of monolayer SnO.	Hydrogen	148-156	strawberry notch homolog 1	Homo sapiens	192-195
32815956-9	2020	Our results indicated that limitation of hydrogen is necessary for the preparation of high-quality p-type two-dimensional SnO, as a small amount of hydrogen produces positive effect on p-type SnO; however, the higher concentration of hydrogen is destructive to the p-type character of monolayer SnO.	Hydrogen	148-156	strawberry notch homolog 1	Homo sapiens	122-125
32815956-9	2020	Our results indicated that limitation of hydrogen is necessary for the preparation of high-quality p-type two-dimensional SnO, as a small amount of hydrogen produces positive effect on p-type SnO; however, the higher concentration of hydrogen is destructive to the p-type character of monolayer SnO.	Hydrogen	148-156	strawberry notch homolog 1	Homo sapiens	192-195
32815956-9	2020	Our results indicated that limitation of hydrogen is necessary for the preparation of high-quality p-type two-dimensional SnO, as a small amount of hydrogen produces positive effect on p-type SnO; however, the higher concentration of hydrogen is destructive to the p-type character of monolayer SnO.	Hydrogen	148-156	strawberry notch homolog 1	Homo sapiens	192-195
33711765-6	2021	The co-crystal structure of 3b in complex with fully active CDK2 was solved, revealing the binding mode of 3b in the ATP pocket and a hydrogen bonding interaction with hinge region residue Leu83.	Hydrogen	134-142	cyclin dependent kinase 2	Homo sapiens	60-64
32881988-6	2020	The NS5-V372A and NS5-H386Y variations resulted in alterations in the number of hydrogen bonds formed with neighboring residues, which were associated with the different ability of the GI and GIII strains to inhibit IFN-alpha and beta production.	Hydrogen	80-88	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	4-7
32881988-6	2020	The NS5-V372A and NS5-H386Y variations resulted in alterations in the number of hydrogen bonds formed with neighboring residues, which were associated with the different ability of the GI and GIII strains to inhibit IFN-alpha and beta production.	Hydrogen	80-88	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	18-21
33792323-8	2021	The hydrogen bonding, hydrophobic, pi-pi, and N-H-pi stacking interactions are the driving forces for the ATP induced inhibition of hIAPP aggregation.	Hydrogen	4-12	islet amyloid polypeptide	Homo sapiens	132-137
32881988-6	2020	The NS5-V372A and NS5-H386Y variations resulted in alterations in the number of hydrogen bonds formed with neighboring residues, which were associated with the different ability of the GI and GIII strains to inhibit IFN-alpha and beta production.	Hydrogen	80-88	interferon alpha 2	Homo sapiens	216-225
32707278-8	2020	Formation of hydrogen bonds favour selective inhibition of COX-2 while hydrophobic interactions favour selective inhibition of COX-1.	Hydrogen	13-21	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	59-64
33858315-14	2022	Binding mode analysis for CDK2 inhibition studies indicate that hydrogen bonding interaction with Lys 33 and Leu83 are important for the activity.	Hydrogen	64-72	cyclin dependent kinase 2	Homo sapiens	26-30
32115907-0	2020	Breaking a single hydrogen bond in the mitochondrial tRNAPhe -PheRS complex leads to phenotypic pleiotropy of human disease.	Hydrogen	18-26	phenylalanyl-tRNA synthetase 2, mitochondrial	Homo sapiens	62-67
32115907-8	2020	Asp364 is hydrogen bonded (HB) to G34 in WT hmit-PheRS.	Hydrogen	10-18	phenylalanyl-tRNA synthetase 2, mitochondrial	Homo sapiens	49-54
33159807-0	2021	1H, 13C, and 15N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10.	Hydrogen	0-2	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	93-98
33392924-2	2021	To capture insights into the dynamics of the protein"s backbone in solution and accelerate the identification and mapping of ligand-binding surfaces through chemical shift perturbation studies, the backbone 1H, 13C, and 15N NMR chemical shifts for Nsp9 have been extensively assigned.	Hydrogen	207-209	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	248-252
32739833-4	2020	However, for native RNase 2, molecular dynamics and NMR studies revealed that the mannopyranosyl residue favors a specific conformation, which optimally stabilizes the protein fold through a network of hydrogen bonds and which leads to a significant reduction of the protein dynamics on the microsecond timescale.	Hydrogen	202-210	ribonuclease A family member 2	Homo sapiens	20-27
33392924-4	2021	A major feature of the assignments was the "missing" amide resonances for N96-L106 in the 1H-15N HSQC spectrum, a region that comprises almost the complete C-terminal alpha-helix that forms a major part of the homodimer interface in the crystal structure of SARS-CoV-2 Nsp9, suggesting this region either undergoes intermediate motion in the ms to mus timescale and/or is heterogenous.	Hydrogen	90-92	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	269-273
32667811-8	2020	The hydrogen exchange behavior of the Ste11 dimer under physiological salt concentration reveals two metastable partially folded intermediate states, which may be generated by a sequential and cooperative unfolding of the five helices of the fold.	Hydrogen	4-12	mitogen-activated protein kinase kinase kinase STE11	Saccharomyces cerevisiae S288C	38-43
33827004-7	2021	Several hydrogen bonds and pi-stacking restrict the position of CPZ isomers in the active cavity of CYPs so that the 4"-nitrogen on the triazole ring can bind closely to the heme of CYP, which results in the metabolism of CPZ isomers.	Hydrogen	8-16	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	100-103
32762417-5	2021	In silico mutational analysis revealed loss of important intermolecular hydrogen bonds and other non-bonded contacts, critical for molecular recognition of SARS-CoV-2 RBD to ACE2, which is well supported by saturation mutagenesis study of binding interface residues.	Hydrogen	72-80	angiotensin converting enzyme 2	Homo sapiens	174-178
33554430-5	2021	The results reveal that the Zn@ZnF2 electrode can effectively inhibit dendrites growth, restrain the hydrogen evolution reactions, and endow excellent plating/stripping reversibility.	Hydrogen	101-109	zinc finger protein 2	Homo sapiens	31-35
32126674-8	2020	Finally, it was found that the average amount of hydrogen bond in SPA was reduced in the presence of Ag which was origin of antimicrobial activity of Ag.	Hydrogen	49-57	surfactant protein A1	Homo sapiens	66-69
32126720-2	2020	Mg- Ni alloys have been considered promising materials for hydrogen storage systems as the Mg2Ni intermetallic phase enhances the kinetics of hydrogen absorption in Mg-Ni alloys through a catalytic effect.	Hydrogen	59-67	mucin 7, secreted	Homo sapiens	91-94
32126720-2	2020	Mg- Ni alloys have been considered promising materials for hydrogen storage systems as the Mg2Ni intermetallic phase enhances the kinetics of hydrogen absorption in Mg-Ni alloys through a catalytic effect.	Hydrogen	142-150	mucin 7, secreted	Homo sapiens	91-94
33445156-9	2021	Molecular modeling studies revealed key nonpolar interactions with Val308, Phe548, His556, and Cys533 and hydrogen bonds with both Asp211 and Asp308 as responsible for the high SphK2 inhibition and selectivity.	Hydrogen	106-114	sphingosine kinase 2	Homo sapiens	177-182
32844025-6	2020	All structures except III display weak hydrogen-bonding inter-actions between the N-H of the ligand and the mu2 and mu3-I- atoms.	Hydrogen	39-47	adaptor related protein complex 1 subunit mu 2	Homo sapiens	108-121
33173250-10	2021	A rich pattern of hydrogen and hydrophobic interactions of the construct was observed with the TLR3 allowing stable binding of the construct at the docked site as predicted by the molecular dynamics simulation and MM-PBSA binding energies.	Hydrogen	18-26	toll like receptor 3	Homo sapiens	95-99
32614348-6	2020	Furthermore, for the hydrogen evolution reaction (HER), a low overpotential of 243 mV at a current density of 10 mA cm-2 and a small Tafel slope of 111 mV dec-1 in acidic media were shown.	Hydrogen	21-29	deleted in esophageal cancer 1	Homo sapiens	155-160
32490196-6	2020	Hydrogen atom transfer proceeds via a sigma-channel in AlkBH2-dsDNA and AlkB-dsDNA; in AlkB-ssDNA, there is a competition between sigma- and pi-channels, implying that the nature of the complexed DNA has potential to alter molecular orbital interactions during the substrate oxidation.	Hydrogen	0-8	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	55-61
32618322-0	2020	Cobalt doping of FePS3 promotes intrinsic active sites for the efficient hydrogen evolution reaction.	Hydrogen	73-81	sodium voltage-gated channel alpha subunit 11	Homo sapiens	17-22
33043577-4	2021	Unambiguously identified among nine possible isomers by multinuclear solution NMR (1H, 13C and 29Si), MALDI-MS, FTIR and computational studies, this represents the largest single-isomer functionalized Tn compound isolated to date.	Hydrogen	83-85	C-type lectin domain family 3 member B	Homo sapiens	201-203
32331779-6	2020	The chiral recognition mechanism was investigated by molecular docking and molecular mechanics, which revealed strong hydrogen bonding between Kynurenine enantiomers and the SD-CSs as compared to individual CS as the key player in binding, formation of stable complexes which led to the ultimate separation.	Hydrogen	118-126	citrate synthase	Homo sapiens	177-179
32314827-0	2020	Structural Transformation of SnS2 to SnS by Mo Doping Produces Electro/Photocatalyst for Hydrogen Production.	Hydrogen	89-97	sodium voltage-gated channel alpha subunit 11	Homo sapiens	29-33
32314827-1	2020	SnS and SnS 2 are layered semiconductors, with potential promising properties for electro-catalytic and photocatalytic hydrogen (H 2 ) production.	Hydrogen	119-127	sodium voltage-gated channel alpha subunit 11	Homo sapiens	8-13
32314827-3	2020	Here, we provide the first report of structural transformation of SnS 2 into SnS with Mo-doping as a bifunctional catalyst for the hydrogen evolution reaction (HER).	Hydrogen	131-139	sodium voltage-gated channel alpha subunit 11	Homo sapiens	66-71
32371482-0	2020	Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol O-methyltransferase reaction.	Hydrogen	0-8	catechol-O-methyltransferase	Homo sapiens	95-123
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	90-98	angiotensin converting enzyme 2	Homo sapiens	72-77
32371482-8	2020	Here, we present a hydrogen/deuterium exchange (HDX)-mass spectrometric study of wild type and mutant COMT, comparing temperature dependences of HDX against corresponding kinetic and cofactor binding parameters.	Hydrogen	19-27	catechol-O-methyltransferase	Homo sapiens	102-106
33602511-10	2021	Reorientation of several crucial residues at the RBD-ACE2 interface facilitates additional hydrogen bond formation for the V367F variant which enhances the binding energy during ACE2 recognition.	Hydrogen	91-99	angiotensin converting enzyme 2	Homo sapiens	53-57
32088442-0	2020	Facile fabrication of novel Ag2S/K-g-C3N4 composite and its enhanced performance in photocatalytic H2 evolution.	Hydrogen	99-101	angiotensin II receptor type 1	Homo sapiens	28-32
33602511-10	2021	Reorientation of several crucial residues at the RBD-ACE2 interface facilitates additional hydrogen bond formation for the V367F variant which enhances the binding energy during ACE2 recognition.	Hydrogen	91-99	angiotensin converting enzyme 2	Homo sapiens	178-182
32088442-1	2020	This work synthesized a novel Ag2S/K-g-C3N4 photocatalyst which was effective in photocatalytic hydrogen production under simulated sunlight and visible light.	Hydrogen	96-104	angiotensin II receptor type 1	Homo sapiens	30-34
33387885-7	2021	The formation of two strong hydrogen bonds between N-(4[(2E)-3-(phenyl)-1-(phenyl)-prop-2-en-1-one]) acetamide (PAAB) and the NSP16-NSP10 heterodimer methyltransferase was also noted.	Hydrogen	28-36	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	132-137
33404211-6	2021	We suggest that the higher stability of the Pt(111)-Mad interface stems from melamine"s ability to form intermolecular hydrogen bonds, which effectively turns the melamine molecules into larger macromolecular entities with multiple anchoring sites and thus more difficult to remove.	Hydrogen	119-127	MAX dimerization protein 1	Homo sapiens	52-55
32000156-4	2020	With an overpotential of 150 mV at a current density of -10 mA/cm2 and a Tafel slope of 39 mV dec-1, this material exhibited excellent catalytic hydrogen evolution activity, which could open the path for designing commercial electrocatalysts.	Hydrogen	145-153	deleted in esophageal cancer 1	Homo sapiens	94-99
33462277-3	2021	Moreover, we designed an effective nanoparticle system for the doxorubicin (DOX) delivery targeting the oral squamous cell carcinoma (OSCC) by mediating the HN-1 (TSPLNIHNGQKL) through hydrogen and pi-pi bonds.	Hydrogen	185-193	Jupiter microtubule associated homolog 1	Homo sapiens	157-161
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Hydrogen	57-65	deleted in esophageal cancer 1	Homo sapiens	170-175
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Hydrogen	57-65	deleted in esophageal cancer 1	Homo sapiens	244-249
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Hydrogen	180-188	deleted in esophageal cancer 1	Homo sapiens	170-175
32347283-3	2020	This hybrid delivers superior catalytic performances for hydrogen/oxygen evolution reactions and overall water splitting: it shows an ultra-small Tafel slope of 28.56 mV dec-1 for hydrogen evolution in acid, and a small Tafel slope of 42.77 mV dec-1 for the oxygen evolution reaction; particularly, in a two-electrode setup for water splitting, it requires an ultra-small potential of 1.59 V to obtain 10 mA cm-2 with nearly 100% faradaic efficiencies for H2 and O2.	Hydrogen	180-188	deleted in esophageal cancer 1	Homo sapiens	244-249
33443672-10	2021	In silico analysis and molecular structural modeling, the mutation not only caused the loss of a hydrogen bond within the p150 protein but also affected the formation of hydrogen bonds between p150 and EB.	Hydrogen	97-105	chromatin assembly factor 1 subunit A	Homo sapiens	122-126
33443672-10	2021	In silico analysis and molecular structural modeling, the mutation not only caused the loss of a hydrogen bond within the p150 protein but also affected the formation of hydrogen bonds between p150 and EB.	Hydrogen	97-105	chromatin assembly factor 1 subunit A	Homo sapiens	193-197
33443672-10	2021	In silico analysis and molecular structural modeling, the mutation not only caused the loss of a hydrogen bond within the p150 protein but also affected the formation of hydrogen bonds between p150 and EB.	Hydrogen	170-178	chromatin assembly factor 1 subunit A	Homo sapiens	122-126
33443672-10	2021	In silico analysis and molecular structural modeling, the mutation not only caused the loss of a hydrogen bond within the p150 protein but also affected the formation of hydrogen bonds between p150 and EB.	Hydrogen	170-178	chromatin assembly factor 1 subunit A	Homo sapiens	193-197
32156684-7	2020	Metabolite analysis of the urine of Fmo1-null mice by 1H NMR spectroscopy revealed a build-up of hypotaurine and a deficit of taurine in comparison with the concentrations of these compounds in the urine of wild-type mice.	Hydrogen	54-56	flavin containing monooxygenase 1	Mus musculus	36-40
33283643-2	2021	Tenapanor is a non-binder, sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor that reduces paracellular intestinal phosphate absorption.	Hydrogen	34-42	solute carrier family 9 member A3	Rattus norvegicus	64-68
32302306-5	2020	NADPH oxidase NOX1 downregulation in response to cuff injury was shown in the hydrogen group, but the expression levels of NADPH oxidase subunits, p40phox and p47phox, did not differ significantly between the hydrogen and control groups.	Hydrogen	78-86	NADPH oxidase 1	Mus musculus	14-18
33272568-10	2021	Reorientation of several crucial residues at the RBD-ACE2 interface facilitates additional hydrogen bond formation for the V367F variant which enhances the binding energy during ACE2 recognition.	Hydrogen	91-99	angiotensin converting enzyme 2	Homo sapiens	53-57
32236261-5	2020	Our results show that the CO molecule mainly interacts with the mu2-OH hydroxo groups of InOF-1 through O-HO hydrogen bonds, and Cpi interactions by the biphenyl rings of the MOF.	Hydrogen	109-117	adaptor related protein complex 1 subunit mu 2	Homo sapiens	64-67
32058932-13	2020	In both animal and cell research, hydrogen reduced TNF-alpha, IL-6 and HMGB1 levels and M1 polarization, but increased IL-10 and TGF-beta levels and M2 polarization.	Hydrogen	34-42	high mobility group box 1	Mus musculus	71-76
33272568-10	2021	Reorientation of several crucial residues at the RBD-ACE2 interface facilitates additional hydrogen bond formation for the V367F variant which enhances the binding energy during ACE2 recognition.	Hydrogen	91-99	angiotensin converting enzyme 2	Homo sapiens	178-182
32108985-0	2020	Hydrogen exerts neuroprotection by activation of the miR-21/PI3K/AKT/GSK-3beta pathway in an in vitro model of traumatic brain injury.	Hydrogen	0-8	glycogen synthase kinase 3 alpha	Rattus norvegicus	69-78
33122085-6	2021	The formation of Y4: P38 hydrogen-bond interaction between the peptide and eIF4E is a rate limiting event in the efficient recognition of the protein since it occurs through the disordered region of the peptide.	Hydrogen	25-33	eukaryotic translation initiation factor 4E	Homo sapiens	75-80
32108985-2	2020	In this study, we explored neuroprotection of hydrogen-rich medium through activation of the miR-21/PI3K/AKT/GSK-3beta pathway in an in vitro model of traumatic brain injury.	Hydrogen	46-54	glycogen synthase kinase 3 alpha	Rattus norvegicus	109-118
32108985-12	2020	In conclusion, hydrogen exerted a neuroprotective effect against neuronal apoptosis and impaired nerve regeneration through activation of miR-21/PI3K/AKT/GSK-3beta signalling in this in vitro model of traumatic brain injury.	Hydrogen	15-23	glycogen synthase kinase 3 alpha	Rattus norvegicus	154-163
32110802-8	2020	The molecular docking and molecular dynamic simulation results of HSF1/Sch A suggested that Sch A formed key hydrogen bond and hydrophobic interactions with HSF1, which may contribute to its potent HSF1 inhibition.	Hydrogen	109-117	heat shock transcription factor 1	Homo sapiens	66-70
33645072-19	2021	The results of molecular docking showed that limonin, palmatine and berberine could bind to CASP3 and MMP9 by hydrogen bond.	Hydrogen	110-118	matrix metallopeptidase 9	Mus musculus	102-106
32110802-8	2020	The molecular docking and molecular dynamic simulation results of HSF1/Sch A suggested that Sch A formed key hydrogen bond and hydrophobic interactions with HSF1, which may contribute to its potent HSF1 inhibition.	Hydrogen	109-117	heat shock transcription factor 1	Homo sapiens	157-161
32110802-8	2020	The molecular docking and molecular dynamic simulation results of HSF1/Sch A suggested that Sch A formed key hydrogen bond and hydrophobic interactions with HSF1, which may contribute to its potent HSF1 inhibition.	Hydrogen	109-117	heat shock transcription factor 1	Homo sapiens	157-161
32853467-2	2020	The release of   CF3 radical occurred from temperature above 85  C. Deeper 1H and 19F nuclear magnetic resonance spectroscopies of the resulting fluorinated polystyrenes (CF3-PSts) evidenced the presence of both CF3 end-group of the PSt chain and the trifluoromethylation of the phenyl ring (in meta position mainly).	Hydrogen	75-77	sulfotransferase family 1A member 1	Homo sapiens	175-178
32083865-2	2020	While performing Arrhenius studies during H2 oxidation over Au/TiO2 catalysts, we found different apparent activation energies (Eapp) depending on the feed water pressure.	Hydrogen	42-44	E2F associated phosphoprotein	Homo sapiens	128-132
33277614-6	2020	Hydrogen deuterium exchange MS showed that Rab1, Rab11 and Rab43 share a conserved binding interface.	Hydrogen	0-8	RAB1A, member RAS oncogene family	Homo sapiens	43-47
32050066-8	2020	To provide insight into further structure-based lead optimization, we solved the crystal structure of hFXR complexed with compound XJ034 that uncovers a unique hydrogen bond between compound XJ034 and residue Y375.	Hydrogen	160-168	nuclear receptor subfamily 1 group H member 4	Homo sapiens	102-106
33277614-6	2020	Hydrogen deuterium exchange MS showed that Rab1, Rab11 and Rab43 share a conserved binding interface.	Hydrogen	0-8	RAB11A, member RAS oncogene family	Homo sapiens	49-54
31995783-8	2020	We showed that V230E stabilized Kv7.4 channel in the closed state by forming an additional hydrogen bond with a basic residue K325, while G287R distorted the selectivity filter and blocked the pore region of Kv7.4 channel.	Hydrogen	91-99	potassium voltage-gated channel subfamily Q member 4	Homo sapiens	32-37
33291618-1	2020	The hydrogen production reaction of the proton exchange membrane (PEM) water electrolysis cell stack is the reverse reaction of the fuel cell, but the water electrolysis operation requires high pressure, and the high pressure decomposes hydrogen molecules, thus aging or causing failure in the water electrolysis cell stack.	Hydrogen	4-12	mucin 1, cell surface associated	Homo sapiens	66-69
33291618-1	2020	The hydrogen production reaction of the proton exchange membrane (PEM) water electrolysis cell stack is the reverse reaction of the fuel cell, but the water electrolysis operation requires high pressure, and the high pressure decomposes hydrogen molecules, thus aging or causing failure in the water electrolysis cell stack.	Hydrogen	237-245	mucin 1, cell surface associated	Homo sapiens	66-69
32739091-5	2020	During the 50 days period, the average hydrogen and caproate production were 1.78 +- 0.75 LH2/L/d and 133.4 +- 17.9 mmol C/L/d, respectively.	Hydrogen	39-47	LIM homeobox 2	Homo sapiens	90-93
31903655-0	2020	Hydrogen Bond Assisted L to D Conversion of alpha-Amino Acids Rui Fu, Soon Mog So, Alan J. Lough, and Jik Chin.	Hydrogen	0-8	myelin oligodendrocyte glycoprotein	Homo sapiens	75-78
31924613-6	2020	Hydrogen-dependent reduction of TrxR was 7-fold less efficient than when NADPH was the electron donor.	Hydrogen	0-8	thioredoxin-disulfide reductase	Thermococcus onnurineus NA1	32-36
32413669-2	2020	This study aimed to investigate whether dehydroabietic acid (DA), a naturally occurred compound, can bind to and activate both PPAR-gamma and PPAR-alpha to ameliorate IR and hepatic steatosis in high-fat diet (HFD)-fed mice.. We found that DA formed stable hydrogen bonds with the ligand-binding domains of PPAR-gamma and PPAR-alpha.	Hydrogen	257-265	peroxisome proliferator activated receptor gamma	Mus musculus	127-137
32560476-4	2020	Meanwhile, the tensile strength of PVA-2CNC-1LNP increased from 26 for neat PVA to 35.4 MPa, without sacrificing the ductility, which could be explained by a sacrificial hydrogen bond reinforcing mechanism induced by spherical-like LNP.	Hydrogen	170-178	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	40-45
33330626-10	2020	Also, the stable hydrogen bonds between Ala83 (nsp16) and Tyr96 (nsp10), and between Gln87 (nsp16) and Leu45 (nsp10) play a vital role in the dimerization of nsp16 and nsp10.	Hydrogen	17-25	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	65-70
32459480-5	2020	This results in a high barrier for hydride formation but a facile addition and activation of CO2 via an eta2 coordination and stabilizing hydrogen bonding by the amine group.	Hydrogen	138-146	DNA polymerase iota	Homo sapiens	104-108
31744771-5	2020	We further recognised that the C NMR chemical shifts of the nominal phenyl carbons (C(3)/C(7) and C(4)/C(6)) encode information for intramolecular hydrogen bonding network formed by GA conformers.	Hydrogen	147-155	complement C6	Homo sapiens	103-107
33330626-10	2020	Also, the stable hydrogen bonds between Ala83 (nsp16) and Tyr96 (nsp10), and between Gln87 (nsp16) and Leu45 (nsp10) play a vital role in the dimerization of nsp16 and nsp10.	Hydrogen	17-25	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	110-115
33330626-10	2020	Also, the stable hydrogen bonds between Ala83 (nsp16) and Tyr96 (nsp10), and between Gln87 (nsp16) and Leu45 (nsp10) play a vital role in the dimerization of nsp16 and nsp10.	Hydrogen	17-25	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	110-115
31911441-3	2020	In the SETD3 active site, Asn255 engages in a unique hydrogen-bonding interaction with the target histidine of actin that likely contributes to its >1300-fold greater catalytic efficiency (k cat/Km ) on histidine than on lysine.	Hydrogen	53-61	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	7-12
33228044-9	2020	Computational molecular docking experiments corroborated these site-competitive experiments, revealing key hydrogen bonding interactions involved in stabilization of both AICAR-HSA complexes, reaffirming that AICAR binds to both site I and site II.	Hydrogen	107-115	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	171-176
32420740-4	2020	Secondly, final product formation involves a hydrogen atom transfer (HAT) from a neutral radical intermediate to TRIP radical, instead of single electron transfer (SET) to *[IrIII].	Hydrogen	45-53	TRAF interacting protein	Homo sapiens	113-117
32420740-6	2020	The calculated results rationalize the experimentally observed enantio- and regioselectivities, and reveal that enantioselectivity of the reaction originates from the hydrogen bond interaction between TRIP and the N-H group of the carbon-centered radical, and the regioselectivity arises from the electron-withdrawing inductive effect from protonated N-atom and intramolecular hydrogen bond interaction between the acetylamino group and the protonated pyridine ring.	Hydrogen	167-175	TRAF interacting protein	Homo sapiens	201-205
32420740-6	2020	The calculated results rationalize the experimentally observed enantio- and regioselectivities, and reveal that enantioselectivity of the reaction originates from the hydrogen bond interaction between TRIP and the N-H group of the carbon-centered radical, and the regioselectivity arises from the electron-withdrawing inductive effect from protonated N-atom and intramolecular hydrogen bond interaction between the acetylamino group and the protonated pyridine ring.	Hydrogen	377-385	TRAF interacting protein	Homo sapiens	201-205
32040646-0	2020	Hydrogen Can Passivate Carbon Impurities in Mg-Doped GaN.	Hydrogen	0-8	gigaxonin	Homo sapiens	53-56
32040646-1	2020	The effect of unintentionally doped hydrogen on the properties of Mg-doped p-GaN samples grown via metal-organic chemical vapor deposition (MOCVD) is investigated through room temperature photoluminescence (PL) and Hall and secondary ion mass spectroscopy (SIMS) measurements.	Hydrogen	36-44	gigaxonin	Homo sapiens	77-80
32905943-12	2020	Both Galloflavin and Ellagic acid were able to form hydrogen bonds with Asp188 and Gly6 in SIRT6.	Hydrogen	52-60	sirtuin 6	Homo sapiens	91-96
32040646-5	2020	This suggests that the co-doped hydrogen not only passivate MgGa, but also can passivate carbon impurities in Mg-doped p-GaN.	Hydrogen	32-40	gigaxonin	Homo sapiens	121-124
32324398-11	2020	According to potential-energy mapping, MA1+  was separated from energetically favorable non-canonical cation radicals by a high-energy barrier that was calculated to be above the dissociation threshold for loss of a methyl hydrogen atom, thus preventing isomerization.	Hydrogen	223-231	PNMA family member 1	Homo sapiens	39-42
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	126-134	glycogen synthase kinase 3 alpha	Homo sapiens	42-50
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	126-134	glycogen synthase kinase 3 alpha	Homo sapiens	220-228
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	126-134	glycogen synthase kinase 3 alpha	Homo sapiens	220-228
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	324-332	glycogen synthase kinase 3 alpha	Homo sapiens	42-50
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	324-332	glycogen synthase kinase 3 alpha	Homo sapiens	220-228
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	324-332	glycogen synthase kinase 3 alpha	Homo sapiens	220-228
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	324-332	glycogen synthase kinase 3 alpha	Homo sapiens	42-50
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	324-332	glycogen synthase kinase 3 alpha	Homo sapiens	220-228
32292127-3	2020	More importantly, inhibition of PI3 K/Akt/GSK3beta signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3beta signal pathway and was related to the inhibition of autophagy.Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3beta signal pathway.	Hydrogen	324-332	glycogen synthase kinase 3 alpha	Homo sapiens	220-228
32916221-8	2020	Notably, the protection of XQ-1H was abolished by Wnt/GSK3beta/beta-catenin inhibitor XAV939 or beta-catenin siRNA, indicating XQ-1H exerted protection in a Wnt/GSK3beta/beta-catenin dependent profile.	Hydrogen	30-32	glycogen synthase kinase 3 alpha	Mus musculus	54-62
32451705-0	2020	Hydrogen bonds in anoplin peptides aid in identification of a structurally stable therapeutic drug scaffold.	Hydrogen	0-8	activation induced cytidine deaminase	Homo sapiens	35-38
32916221-8	2020	Notably, the protection of XQ-1H was abolished by Wnt/GSK3beta/beta-catenin inhibitor XAV939 or beta-catenin siRNA, indicating XQ-1H exerted protection in a Wnt/GSK3beta/beta-catenin dependent profile.	Hydrogen	30-32	glycogen synthase kinase 3 alpha	Mus musculus	161-169
33463500-0	2020	[Hydrogen plays a protective role in intestinal injury of mice with severe sepsis by regulating the release of heme oxygenase-1 and high mobility group protein B1].	Hydrogen	1-9	high mobility group box 1	Mus musculus	132-162
32406800-5	2021	According to the molecular dynamics simulations, the N340D substitution rearranged complicated hydrogen bond networks in an extensive surface region of neuraminidase.	Hydrogen	95-103	neuraminidase 1	Homo sapiens	152-165
33463500-1	2020	OBJECTIVE: To investigate the protective effect of the hydrogen (H2) inhalation on intestinal injury in severe sepsis mice and its relationship with nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/high mobility group protein B1 (HMGB1) pathway.	Hydrogen	55-63	high mobility group box 1	Mus musculus	215-245
33463500-1	2020	OBJECTIVE: To investigate the protective effect of the hydrogen (H2) inhalation on intestinal injury in severe sepsis mice and its relationship with nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/high mobility group protein B1 (HMGB1) pathway.	Hydrogen	55-63	high mobility group box 1	Mus musculus	247-252
33192289-7	2020	Analysis of the polar contacts and hydrogen bonds, and the root mean square derivation results showed that R726 and R727 of CaMBD formed polar contacts or high occupancy hydrogen bonds with SUMO1.	Hydrogen	170-178	small ubiquitin like modifier 1	Homo sapiens	190-195
32297610-2	2020	The as-obtained electrocatalyst with a defect-rich structure is highly efficient for the hydrogen evolution reaction (HER), delivering a low overpotential of 96 mV at an HER current density of 10 mA cm-2, a small Tafel slope of 60 mV dec-1, and outstanding durability.	Hydrogen	89-97	deleted in esophageal cancer 1	Homo sapiens	234-239
32302111-4	2020	In the acidic media, the Co-SA/P-in situ catalyst with Co-P1N3 interfacial structure exhibits excellent activity and durability for hydrogen evolution reaction (HER) with a low overpotential of 98 mV at 10 mA cm-2 and a small Tafel slope of 47 mV dec-1, which are greatly superior to those of catalyst with Co-N4 interfacial structure.	Hydrogen	132-140	deleted in esophageal cancer 1	Homo sapiens	247-252
32535425-0	2020	Investigation on various photo-generated carrier transfer processes of SnS2/g-C3N4 heterojunction photocatalysts for hydrogen evolution.	Hydrogen	117-125	sodium voltage-gated channel alpha subunit 11	Homo sapiens	71-75
32344647-5	2020	The crystal structure of the AnxA11 core highlights main-chain hydrogen bonding interactions formed through this bridging segment, which are likely conserved in most annexins.	Hydrogen	63-71	annexin A11	Homo sapiens	29-35
32320994-4	2020	Our results showed that the lifespans of the N2, sod-3 and sod-5 mutant strains were extended by approximately 22.7%, 9.5%, and 8.7%, respectively, after hydrogen treatment, but hydrogen had no effect on the lifespans of the daf-2 and daf-16 mutant strains.	Hydrogen	154-162	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	49-54
32535836-4	2020	Here we report the backbone 1H, 13C, 15N assignments of the 38 kDa human CaMK1D protein in its free state, including both the canonical bi-lobed kinase fold as well as the autoinhibitory and calmodulin binding domains.	Hydrogen	28-30	calcium/calmodulin dependent protein kinase ID	Homo sapiens	73-79
32152224-5	2020	Using hydrogen-deuterium exchange (HDX)-MS to monitor the dynamics of HO2 with and without Fe3+-heme bound to the HRMs and to the core, we detected conformational changes in the catalytic core only in one state of the catalytic cycle-when Fe3+-heme is bound to the HRMs and the core is in the apo state.	Hydrogen	6-14	heme oxygenase 2	Homo sapiens	70-73
32736076-2	2020	In this study, a series of novel 2,4-diaminopyrimidine FAK-targeted inhibitors were designed, synthesized and characterized by 1H NMR, 13C HNMR, and HRMS spectra.	Hydrogen	127-129	protein tyrosine kinase 2	Homo sapiens	55-58
31982658-1	2020	O-H   O=C Hydrogen bonding (H-bonding) results in spectral shifts in both nuO-H and nuC=O modes.	Hydrogen	10-18	nucleobindin 1	Homo sapiens	84-87
32945408-6	2020	Liver histopathologic changes evaluated with hematoxylin and eosin as well as Oil Red O staining revealed lower lipid deposition in hydrogen inhalation groups, consistent with the decrease in the expression of the lipid synthesis gene SREBP-1c.	Hydrogen	132-140	sterol regulatory element binding transcription factor 1	Rattus norvegicus	235-243
32090570-0	2020	Aspect Ratio Dependent Charge Carrier Dynamics in Matchstick-like Ag2S-ZnS Nanorods for Solar Hydrogen Generation.	Hydrogen	94-102	angiotensin II receptor type 1	Homo sapiens	66-70
32090570-4	2020	The interfacial electron transfer rate constant (ket) from ZnS to Ag2S could be enhanced about two-orders of magnitude from 5.27 106 to 3.24 108 s-1, leading to a significant efficiency improvement in solar hydrogen generation (SHG).	Hydrogen	207-215	angiotensin II receptor type 1	Homo sapiens	66-70
32090552-5	2020	Thus, the obtained catalyst established by electrocatalytic activity in the course of the oxygen evolution reaction (OER) and the hydrogen evolution reaction (HER) in 1 M KOH solution requires overpotentials (eta) of 290 and 150 mV to achieve a current density of 50 and 10 mA cm-2 for both OER and HER.	Hydrogen	130-138	endothelin receptor type A	Homo sapiens	209-212
33094105-9	2020	These VEGFs are divided mainly into two types and a significant increase in the number of hydrogen bonds within the NZ7-like VEGF dimers was observed.	Hydrogen	90-98	vascular endothelial growth factor A	Ovis aries	6-10
32183375-4	2020	We hypothesized that in early ADPKD, the reactive oxygen species (ROS)-producing nicotinamide adenine dinucleotide phosphate hydrogen (NAD(P)H)-oxidase complex-4 (NOX4), a major source of ROS in renal tubular epithelial cells (TECs) and endothelial cells (ECs), induces EC mitochondrial abnormalities, contributing to endothelial dysfunction, vascular abnormalities, and renal disease progression.	Hydrogen	125-133	NADPH oxidase 4	Homo sapiens	163-167
32344342-2	2020	In this study, 1H NMR validated polyphenols and polysaccharides extracted from sprouted quinoa yoghurt were used as isolates and conjugates to upregulate the stimulation of GLP-1 release in NCI-H716 cells.	Hydrogen	15-17	glucagon like peptide 1 receptor	Homo sapiens	173-178
32178350-0	2020	Evaluations of the Peroxidative Susceptibilities of Cod Liver Oils by a 1H NMR Analysis Strategy: Peroxidative Resistivity of a Natural Collagenous and Biogenic Amine-Rich Fermented Product.	Hydrogen	72-74	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	52-55
32869754-4	2020	For eight hydrogen-bonded clusters involving a chromophore (represented as PsiA) and the glycylglycine molecule [represented as rhoB(r)], FDET is used to derive excitation energies.	Hydrogen	10-18	ras homolog family member B	Homo sapiens	128-132
31993727-0	2020	Mapping binding epitopes of monoclonal antibodies targeting major histocompatibility complex class I chain-related A (MICA) with hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry.	Hydrogen	129-137	MHC class I polypeptide-related sequence A	Homo sapiens	60-116
31993727-0	2020	Mapping binding epitopes of monoclonal antibodies targeting major histocompatibility complex class I chain-related A (MICA) with hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry.	Hydrogen	129-137	MHC class I polypeptide-related sequence A	Homo sapiens	118-122
31993727-4	2020	In this study, we describe the practical utility of hydrogen/deuterium exchange mass spectrometry (HDX-MS) in epitope mapping studies of a cohort of four monoclonal antibodies targeting MICA in a rapid manner.	Hydrogen	52-60	MHC class I polypeptide-related sequence A	Homo sapiens	186-190
32820775-8	2020	Based on voltammetry, it was found that the overpotential of the hydrogen evolution reaction on graphitic carbon nitride equalled 215 mV (at 10 mA cm-2) and the Tafel slope was 95 mV dec-1.	Hydrogen	65-73	deleted in esophageal cancer 1	Homo sapiens	183-188
31923589-8	2020	Structural comparison with uncleaved SEA domains suggests that the number of residues evolutionarily inserted in the cleaved loop of MUC1 SEA precludes the formation of a properly hydrogen-bonded beta turn.	Hydrogen	180-188	mucin 1, cell surface associated	Homo sapiens	133-137
31868085-6	2020	ChIP assay was used to detect the H3 and H4 histone acetylation levels at the ANCR promoter region.	Hydrogen	41-43	Angelman syndrome chromosome region	Homo sapiens	78-82
31868085-11	2020	H3/H4 histone acetylation levels at the ANCR promoter region were elevated in HCC tissues and cells, and interfering histone deacetylases 3 (HDAC3) significantly up-regulated ANCR expression.	Hydrogen	3-5	Angelman syndrome chromosome region	Homo sapiens	40-44
32738139-4	2020	Furthermore, the modelling suggests that TSHbeta and TSHbetav proteins clasped the concave surface of the leucine rich region of the TSHR ECD in a similar way to the native TSH using dynamic hydrogen bonding.	Hydrogen	191-199	glycoprotein hormones, alpha polypeptide	Homo sapiens	41-48
31922747-2	2020	Hydrogen atom transfer (HAT) by 3O2 and HO2  from arenols (ArOH), aryloxyls (ArO ), their tautomers (ArH), and auxiliary compounds has been investigated by means of CBS-QB3 computations.	Hydrogen	0-8	heme oxygenase 2	Homo sapiens	40-43
32033016-2	2020	The results of a molecular docking study showed that the oxygen atom in the five-membered ring of octenyl succinic anhydride (OSA) formed a strong hydrogen bond interaction (1.89 A) with the hydrogen atom in the hydroxyl group of C-6.	Hydrogen	147-155	complement C6	Homo sapiens	230-233
32154208-6	2019	The ESP and Hirshfeld surface analysis indicated that a large number of hydrogen bonds as well as pi-pi stacking interactions within molecules might be the key reason for their low sensitivities and high energy-density levels.	Hydrogen	72-80	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	4-7
32033016-2	2020	The results of a molecular docking study showed that the oxygen atom in the five-membered ring of octenyl succinic anhydride (OSA) formed a strong hydrogen bond interaction (1.89 A) with the hydrogen atom in the hydroxyl group of C-6.	Hydrogen	191-199	complement C6	Homo sapiens	230-233
32464777-5	2020	Besides, SA and A can stabilize IA clusters by the formation of more halogen bonds and hydrogen bonds as well as proton transfers, and the binary nucleation of IA-SA/A rather than the self-nucleation of IA appears to be the dominant pathways in polluted coastal regions, especially in winter.	Hydrogen	87-95	acyl-CoA synthetase medium chain family member 3	Homo sapiens	9-11
31780264-0	2020	Hydrogen treatment prevents lipopolysaccharide-induced pulmonary endothelial cell dysfunction through RhoA inhibition.	Hydrogen	0-8	ras homolog family member A	Mus musculus	102-106
31780264-11	2020	Hydrogen treatment can prevent LPS-induced junctional injury and cell death by inhibiting the activity of RhoA.	Hydrogen	0-8	ras homolog family member A	Mus musculus	106-110
32628440-0	2020	MOF-Derived Sulfide-Based Electrocatalyst and Scaffold for Boosted Hydrogen Production.	Hydrogen	67-75	lysine acetyltransferase 8	Homo sapiens	0-3
31925629-7	2020	We find that this 2-protein biohybrid system produces H2 in aqueous solutions via light-induced interprotein electron transfer reactions (TON > 2500 H2/FNR), providing insight about using native protein-protein interactions as a method for fuel generation.	Hydrogen	54-56	ferredoxin reductase	Homo sapiens	152-155
32064385-10	2020	The computational efficiency and beneficial scaling of the method allow for application to larger systems, as shown for hydrogen abstraction from 2-butanone by HO2  .	Hydrogen	120-128	heme oxygenase 2	Homo sapiens	160-163
32039235-5	2020	Post-dynamics analysis showed that DLG1/4 formed extensive interactions with phosphorylated ligands, including hydrophobic and hydrogen bonding interactions.	Hydrogen	127-135	discs large MAGUK scaffold protein 1	Homo sapiens	35-39
32005101-13	2020	For Danish Jersey, wavenumbers that interact with C-H were associated to genes that are involved in fatty acid synthesis, such as AGPAT3, AGPAT6, PPARGC1A, SREBF1, and FADS1.	Hydrogen	50-53	glycerol-3-phosphate acyltransferase 4	Bos taurus	138-144
32569457-1	2020	Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful tool for protein structure analysis that is well suited for biotherapeutic development and characterization.	Hydrogen	0-8	highly divergent homeobox	Homo sapiens	47-50
31880451-2	2020	Here, 15N/13C spin-echo magic-angle spinning (MAS) solid-state NMR experiments are applied to "view" intermolecular CH   N hydrogen bonding in two selectively labelled organic compounds, 4-[15N] cyano-4"-[13C2] ethynylbiphenyl (1) and [15N3,13C6]-2,4,6-triethynyl-1,3,5-triazine (2).	Hydrogen	123-131	chimerin 1	Homo sapiens	116-122
31880451-4	2020	Experimentally determined hydrogen-bond mediated 2hJCN couplings (4.7 +- 0.4 Hz (1), 4.1 +- 0.3 Hz (2)) are compared with density functional theory (DFT) gauge-including projector augmented wave (GIPAW) calculations, whereby species independent coupling values 2hKCN (28.1 (1), 26.1 (2) x 1019 kg m-2 s-2 A-2) quantitatively demonstrate the J couplings for these CH   N hydrogen bonds to be of a similar magnitude to those for conventionally observed NH   O hydrogen-bonding interactions in uracil (2hKNO: 28.1 and 36.8 x 1019 kg m-2 s-2 A-2).	Hydrogen	26-34	chimerin 1	Homo sapiens	363-369
31899620-5	2020	It is likely that the radical species generated from UV-activated YM-53601 abstract hydrogen atoms from the SQS peptide, leading to the photolysis of the entire protein.	Hydrogen	84-92	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	108-111
32708121-0	2020	Coupling Hydrogenation of Guaiacol with In Situ Hydrogen Production by Glycerol Aqueous Reforming over Ni/Al2O3 and Ni-X/Al2O3 (X = Cu, Mo, P) Catalysts.	Hydrogen	9-17	BCL2 interacting protein 3 like	Homo sapiens	116-120
31859325-1	2020	Rare examples of molecular, dinuclear CeIII and PrIII complexes with robust Ln-coordination are accessible by use of the tetraphenolate pTP as a supporting, chelating O-donor ligand platform, pTP = [{2-(OC6H2R2-2,4)2CH}-C6H4-1,4]4- that favours the higher formal oxidation states accessible to rare earths.	Hydrogen	198-230	protein tyrosine phosphatase receptor type U	Homo sapiens	136-139
31841328-3	2020	Molecular docking predicted that RGM-(Hyp)-GF and the ACE residues of Glu384, His513 and Lys511 formed hydrogen-bonding interactions at distances of 2.57, 2.99 and 2.42+3.0 A. RGL-(Hyp)-GL formed hydrogen bonds with Lys511 and Tyr523 and generated hydrogen-bonding interactions with His387 and Glu411 in the zinc(II) complexation motif at distances of 2.74 and 3.03+1.93 A.	Hydrogen	103-111	angiotensin I converting enzyme	Bos taurus	54-57
31841328-3	2020	Molecular docking predicted that RGM-(Hyp)-GF and the ACE residues of Glu384, His513 and Lys511 formed hydrogen-bonding interactions at distances of 2.57, 2.99 and 2.42+3.0 A. RGL-(Hyp)-GL formed hydrogen bonds with Lys511 and Tyr523 and generated hydrogen-bonding interactions with His387 and Glu411 in the zinc(II) complexation motif at distances of 2.74 and 3.03+1.93 A.	Hydrogen	196-204	angiotensin I converting enzyme	Bos taurus	54-57
31841328-3	2020	Molecular docking predicted that RGM-(Hyp)-GF and the ACE residues of Glu384, His513 and Lys511 formed hydrogen-bonding interactions at distances of 2.57, 2.99 and 2.42+3.0 A. RGL-(Hyp)-GL formed hydrogen bonds with Lys511 and Tyr523 and generated hydrogen-bonding interactions with His387 and Glu411 in the zinc(II) complexation motif at distances of 2.74 and 3.03+1.93 A.	Hydrogen	196-204	angiotensin I converting enzyme	Bos taurus	54-57
31793618-5	2020	The detection mechanisms of probe PPN for Cu2+/Ag+ were confirmed by 1H NMR and HRMS-ESI.	Hydrogen	69-71	porcupine O-acyltransferase	Homo sapiens	34-37
32031748-1	2020	Thioredoxin (Txn) is a hydrogen carrier protein and exists widely in organism.	Hydrogen	23-31	thioredoxin	Gallus gallus	0-11
31739034-6	2020	Thermodynamic data showed that hydrogen bonds have a main role in the ELA-catalase complex formation.	Hydrogen	31-39	catalase	Bos taurus	74-82
31919457-7	2020	Compared with 63 other dog breeds, Greyhounds had the highest CYP2B11-H3 allele frequency, while CYP2B11-H2 was widely distributed across most breeds.	Hydrogen	105-107	cytochrome P450 2B11	Canis lupus familiaris	97-104
31777983-8	2020	Graphene, Cd3 C2 , T-VTe2 , H-VTe2 , and H-TaTe2 CSs lead to subthreshold swing below 60 mV dec-1 .	Hydrogen	28-34	deleted in esophageal cancer 1	Homo sapiens	92-97
32031748-1	2020	Thioredoxin (Txn) is a hydrogen carrier protein and exists widely in organism.	Hydrogen	23-31	thioredoxin	Gallus gallus	13-16
31919457-9	2020	Truncated mRNA transcripts were observed in CYP2B11-H2 and CYP2B11-H3 but not CYP2B11-H1 transfected cells.	Hydrogen	52-54	cytochrome P450 2B11	Canis lupus familiaris	44-51
32056049-4	2020	Resistance to neuraminidase inhibitors has remained at low levels to date and the majority of resistance is seen in influenza A H1N1 pdm09 infected immunocompromised individuals receiving oseltamivir but is also seen less frequently with influenza A H3N2 and B.	Hydrogen	250-254	neuraminidase 1	Homo sapiens	14-27
31911600-5	2020	The synergistic function of Pd1 and PdNPs is assigned so that the partial Pd1 dispersion contributes enough sites for the activation of C=O group while PdNPs site boosts the dissociation of H2 molecules to H atoms.	Hydrogen	190-192	programmed cell death 1	Homo sapiens	28-31
31911600-5	2020	The synergistic function of Pd1 and PdNPs is assigned so that the partial Pd1 dispersion contributes enough sites for the activation of C=O group while PdNPs site boosts the dissociation of H2 molecules to H atoms.	Hydrogen	190-192	programmed cell death 1	Homo sapiens	74-77
30632771-7	2020	Moreover, recent studies related to beta-lactoglobulin (BLG)-mucin interactions have clarified the importance of hydrophobic as well as hydrophilic interactions, such as hydrogen bonding.	Hydrogen	170-178	LOC100508689	Homo sapiens	61-66
31702499-9	2020	RESULT: The PI3K/AKT signaling pathway was significantly activated, while FoxO1, Bim, and Caspase-3 mRNA and protein levels were significantly decreased in the hydrogen-rich water group compared with those in the pre-ischemic and ischemic phase groups.	Hydrogen	160-168	forkhead box O1	Rattus norvegicus	74-79
31702499-9	2020	RESULT: The PI3K/AKT signaling pathway was significantly activated, while FoxO1, Bim, and Caspase-3 mRNA and protein levels were significantly decreased in the hydrogen-rich water group compared with those in the pre-ischemic and ischemic phase groups.	Hydrogen	160-168	caspase 3	Rattus norvegicus	90-99
31702499-10	2020	PI3K, AKT and p-AKT mRNA and protein expression levels were increased, while the FoxO1, Bim and Caspase-3 expression levels were significantly decreased in the hydrogen-water group compared with those in the control group in the ischemia-reperfusion phase (P&amp;lt;0.05).	Hydrogen	160-168	forkhead box O1	Rattus norvegicus	81-86
31702499-10	2020	PI3K, AKT and p-AKT mRNA and protein expression levels were increased, while the FoxO1, Bim and Caspase-3 expression levels were significantly decreased in the hydrogen-water group compared with those in the control group in the ischemia-reperfusion phase (P&amp;lt;0.05).	Hydrogen	160-168	caspase 3	Rattus norvegicus	96-105
32432891-6	2020	The other is denoting an agonist by at least one best docking pose having one hydrogen bond to LXRalpha Helix12 His421.	Hydrogen	78-86	nuclear receptor subfamily 1 group H member 3	Homo sapiens	95-103
31888168-0	2019	Low Temperature Characteristics of Hydrogen Storage Alloy LaMm-Ni4.1Al0.3Mn0.4Co0.45 for Ni-MH Batteries.	Hydrogen	35-43	laminin subunit alpha 2	Homo sapiens	58-62
32409058-5	2020	Here, the CRM ligand with active isocyanate group may be chemically grafted onto the collagen receptor via covalent and hydrogen bonds.	Hydrogen	120-128	integrin subunit alpha 2	Homo sapiens	85-102
31847290-2	2019	Under ambient pressure, the imidazolium C2-H and C4,5-H absorption bands of [C4MIM][PF6]/DNA mixture were red-shifted in comparison with those of pure [C4MIM][PF6].	Hydrogen	49-55	sperm associated antigen 17	Homo sapiens	84-87
31847290-2	2019	Under ambient pressure, the imidazolium C2-H and C4,5-H absorption bands of [C4MIM][PF6]/DNA mixture were red-shifted in comparison with those of pure [C4MIM][PF6].	Hydrogen	49-55	sperm associated antigen 17	Homo sapiens	159-162
31847290-4	2019	With the increase of pressure from ambient to 2.5 GPa, the C2-H and C4,5-H absorption bands of pure [C4MIM][PF6] displayed significant blue shifts.	Hydrogen	68-74	sperm associated antigen 17	Homo sapiens	108-111
31847290-7	2019	Under ambient pressure, the imidazolium C2-H and C4,5-H absorption bands of [C3MIM][PF6]/DNA mixture displayed negligible shifts in frequency compared with those of pure [C3MIM][PF6].	Hydrogen	49-55	sperm associated antigen 17	Homo sapiens	84-87
31842357-3	2019	SWI2/SNF2-Related 1 Chromatin Remodeling Complex (SWR1-C) belongs to the INO80 chromatin remodeling family and mainly catalyzes the exchange of H2A-H2B with the H2A.Z-H2B dimer.	Hydrogen	144-151	switch 2	Arabidopsis thaliana	0-4
31714570-3	2019	The present work shows the first case of employing pressure hydrogenation to prepare hydrogenated ZnIn2S4 (H-ZIS) microspheres with surface-deficient porous structures, which are favorable for furnishing sufficient surface sulfur vacancies to realize excellent photocatalytic hydrogen evolution reactions.	Hydrogen	60-68	zinc finger RANBP2-type containing 2	Homo sapiens	109-112
31714570-4	2019	The hydrogen evolution rate (HER) of H-ZIS is as high as 1.9 mmol h-1 g-1 (nearly 8.6 times that of the pristine ZIS sample), which rivals or exceeds those of previously-reported ZIS-based photocatalysts under visible light irradiation.	Hydrogen	4-12	zinc finger RANBP2-type containing 2	Homo sapiens	39-42
31802759-3	2019	The single-crystal X-ray structure analysis revealed an angle of 13.36 (8)  between the planes of the rings, as well as molecules linked by Nsp2-H...N hydrogen bonds forming dimers along the crystal.	Hydrogen	151-159	reticulon 2	Homo sapiens	140-144
31802759-5	2019	The existence of Nsp2-H...N hydrogen bonds in the crystal was confirmed spectroscopically by the IR peaks from the N-H stretching vibration shifting to lower wavenumbers in the solid state relative to those in the gas phase.	Hydrogen	28-36	reticulon 2	Homo sapiens	17-21
31802759-5	2019	The existence of Nsp2-H...N hydrogen bonds in the crystal was confirmed spectroscopically by the IR peaks from the N-H stretching vibration shifting to lower wavenumbers in the solid state relative to those in the gas phase.	Hydrogen	115-118	reticulon 2	Homo sapiens	17-21
31328318-1	2019	Catalytic transformation of COx (x = 1, 2) with renewable H2 into valuable fuels and chemicals provides practical processes to mitigate the worldwide energy crisis.	Hydrogen	58-60	cytochrome c oxidase subunit 8A	Homo sapiens	28-31
31328318-5	2019	Control synthesis of FeCx -based nanomaterials and their catalytic applications in COx hydrogenation and electrochemical hydrogen evolution reaction (HER) are reviewed.	Hydrogen	87-95	cytochrome c oxidase subunit 8A	Homo sapiens	83-86
31355457-9	2019	CONCLUSIONS AND IMPLICATIONS: Our investigations indicate that low pH selectively impairs mu-opioid receptor signalling modulated by ligands capable of forming hydrogen bonds with H2976.52 .	Hydrogen	160-168	phenylalanine hydroxylase	Homo sapiens	67-69
31535412-16	2019	In addition, H2 inhalation also inhibited BLM-induced epithelial-mesenchymal transitions (EMT) by inhibiting TGF-beta1 to increase the expression level of epithelial cell marker E-cadherin while decrease the expression level of mesenchymal cell marker vimentin in a time-dependent manner.	Hydrogen	13-15	vimentin	Rattus norvegicus	252-260
31613590-1	2019	This study investigates perovskite hydrides (ABH3) comprising alkali metals of A, where A is Li, Na, K, Rb, or Cs, and alkaline-earth metals of B, where B is Be, Mg, Ca, Sr, or Ba, to screen the highest potential hydrides for hydrogen release.	Hydrogen	226-234	alkB homolog 3, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	45-49
31613603-5	2019	The redox-active complex was used as a heterogeneous catalyst for electrochemical hydrogen evolution from aqueous medium at pH 7 with a turnover frequency (TOF) of 384 h-1 and a Tafel slope of 274 mV dec-1.	Hydrogen	82-90	deleted in esophageal cancer 1	Homo sapiens	200-205
31737059-11	2019	In contrast, knockdown of RFX1 in CD14+ monocytes reduced the recruitments of HDAC1 and SUV39H1 in the MCP1 promoter region, thereby facilitating H3 and H4 acetylation and H3K9 tri-methylation in this region.	Hydrogen	153-155	CD14 molecule	Homo sapiens	34-38
31737609-3	2019	The results show that after the tetralin liquid reacts with high-pressure hydrogen, 90% of the reaction product is in liquid state, the gaseous products mainly include alkane gas and COx gas.	Hydrogen	74-82	cytochrome c oxidase subunit 8A	Homo sapiens	183-186
31553612-4	2019	Assessing the asynchronicity parameter (eta) for the studied substituents reveals that pKa is a larger driving force in the rate-determining hydrogen transfer reaction than the BDFE, which suggest a reasonable amount of protic character in the transition state, and possible routes to the design of more active catalysts with greater substrate scope.	Hydrogen	141-149	endothelin receptor type A	Homo sapiens	40-43
31687022-8	2019	Per Glu380Lys, Glu with negative charges has been changed into Lys with positive charges, which may affect the hydrogen bond formation between amino acids and the stability of the local structure, thus affecting the binding of zinc iron to MKRN3 protein.	Hydrogen	111-119	makorin ring finger protein 3	Homo sapiens	240-245
30937734-7	2019	1H, 13C and 15N chemical shifts of Scm3 have been obtained by various 2D and 3D heteronuclear NMR experiments at pH 7.4 and 283 K.	Hydrogen	0-2	Scm3p	Saccharomyces cerevisiae S288C	35-39
31030336-6	2019	Here, we report 1H, 13C and 15N resonance assignments for the GTP 9-12-aptamer bound to GTP as the prerequisite for the structure determination by solution NMR.	Hydrogen	16-18	mitochondrial ribosome associated GTPase 1	Homo sapiens	62-65
31030336-6	2019	Here, we report 1H, 13C and 15N resonance assignments for the GTP 9-12-aptamer bound to GTP as the prerequisite for the structure determination by solution NMR.	Hydrogen	16-18	mitochondrial ribosome associated GTPase 1	Homo sapiens	88-91
30486742-6	2019	The binding mode of TAA found in Site 1 formed hydrogen bonds with Lys37 and Asp125 on p65, important residues near DNA-binding region.	Hydrogen	47-55	RELA proto-oncogene, NF-kB subunit	Homo sapiens	87-90
31509818-1	2020	A palladium nanoparticles decorated three-dimensional polyacrylonitrile nanofiber network (Pd-PAN) is prepared as a hydrogen sensor by a chemical bath method.	Hydrogen	116-124	adenosine deaminase 2	Homo sapiens	94-97
31509818-3	2020	The prepared Pd-PAN device exhibits stable performance for hydrogen detection with high sensitivity, especially under low-concentration hydrogen environment.	Hydrogen	59-67	adenosine deaminase 2	Homo sapiens	16-19
31509818-3	2020	The prepared Pd-PAN device exhibits stable performance for hydrogen detection with high sensitivity, especially under low-concentration hydrogen environment.	Hydrogen	136-144	adenosine deaminase 2	Homo sapiens	16-19
31509818-9	2020	The systematic measurements demonstrate the promising application of Pd-PAN sensor for low-concentration hydrogen detecting.	Hydrogen	105-113	adenosine deaminase 2	Homo sapiens	72-75
31919301-4	2020	The molecules in the linear hexadepsipeptide amide in (S)-Pms-Acp-(S)-Pms-Acp-(S)-Pms-Acp-NMe2 acetonitrile solvate, C47H58N4O9 C2H3N, (3b), as well as in the related linear tetradepsipeptide amide (S)-Pms-Aib-(S)-Pms-Aib-NMe2, C28H37N3O6, (5a), the diastereoisomeric mixture (S,R)-Pms-Acp-(R,S)-Pms-Acp-NMe2/(R,S)-Pms-Acp-(R,S)-Pms-Acp-NMe2 (1:1), C32H41N3O6, (5b), and (R,S)-Mns-Acp-(S,R)-Mns-Acp-NMe2, C30H37N3O6, (5c) (Pms is phenyllactic acid, Acp is 1-aminocyclopentanecarboxylic acid and Mns is mandelic acid), generally adopt a beta-turn conformation in the solid state, which is stabilized by intramolecular N-H...O hydrogen bonds.	Hydrogen	623-633	CPAT1	Homo sapiens	62-65
31919301-4	2020	The molecules in the linear hexadepsipeptide amide in (S)-Pms-Acp-(S)-Pms-Acp-(S)-Pms-Acp-NMe2 acetonitrile solvate, C47H58N4O9 C2H3N, (3b), as well as in the related linear tetradepsipeptide amide (S)-Pms-Aib-(S)-Pms-Aib-NMe2, C28H37N3O6, (5a), the diastereoisomeric mixture (S,R)-Pms-Acp-(R,S)-Pms-Acp-NMe2/(R,S)-Pms-Acp-(R,S)-Pms-Acp-NMe2 (1:1), C32H41N3O6, (5b), and (R,S)-Mns-Acp-(S,R)-Mns-Acp-NMe2, C30H37N3O6, (5c) (Pms is phenyllactic acid, Acp is 1-aminocyclopentanecarboxylic acid and Mns is mandelic acid), generally adopt a beta-turn conformation in the solid state, which is stabilized by intramolecular N-H...O hydrogen bonds.	Hydrogen	623-633	CPAT1	Homo sapiens	74-77
31919301-4	2020	The molecules in the linear hexadepsipeptide amide in (S)-Pms-Acp-(S)-Pms-Acp-(S)-Pms-Acp-NMe2 acetonitrile solvate, C47H58N4O9 C2H3N, (3b), as well as in the related linear tetradepsipeptide amide (S)-Pms-Aib-(S)-Pms-Aib-NMe2, C28H37N3O6, (5a), the diastereoisomeric mixture (S,R)-Pms-Acp-(R,S)-Pms-Acp-NMe2/(R,S)-Pms-Acp-(R,S)-Pms-Acp-NMe2 (1:1), C32H41N3O6, (5b), and (R,S)-Mns-Acp-(S,R)-Mns-Acp-NMe2, C30H37N3O6, (5c) (Pms is phenyllactic acid, Acp is 1-aminocyclopentanecarboxylic acid and Mns is mandelic acid), generally adopt a beta-turn conformation in the solid state, which is stabilized by intramolecular N-H...O hydrogen bonds.	Hydrogen	623-633	CPAT1	Homo sapiens	74-77
31919301-4	2020	The molecules in the linear hexadepsipeptide amide in (S)-Pms-Acp-(S)-Pms-Acp-(S)-Pms-Acp-NMe2 acetonitrile solvate, C47H58N4O9 C2H3N, (3b), as well as in the related linear tetradepsipeptide amide (S)-Pms-Aib-(S)-Pms-Aib-NMe2, C28H37N3O6, (5a), the diastereoisomeric mixture (S,R)-Pms-Acp-(R,S)-Pms-Acp-NMe2/(R,S)-Pms-Acp-(R,S)-Pms-Acp-NMe2 (1:1), C32H41N3O6, (5b), and (R,S)-Mns-Acp-(S,R)-Mns-Acp-NMe2, C30H37N3O6, (5c) (Pms is phenyllactic acid, Acp is 1-aminocyclopentanecarboxylic acid and Mns is mandelic acid), generally adopt a beta-turn conformation in the solid state, which is stabilized by intramolecular N-H...O hydrogen bonds.	Hydrogen	623-633	CPAT1	Homo sapiens	74-77
31919301-4	2020	The molecules in the linear hexadepsipeptide amide in (S)-Pms-Acp-(S)-Pms-Acp-(S)-Pms-Acp-NMe2 acetonitrile solvate, C47H58N4O9 C2H3N, (3b), as well as in the related linear tetradepsipeptide amide (S)-Pms-Aib-(S)-Pms-Aib-NMe2, C28H37N3O6, (5a), the diastereoisomeric mixture (S,R)-Pms-Acp-(R,S)-Pms-Acp-NMe2/(R,S)-Pms-Acp-(R,S)-Pms-Acp-NMe2 (1:1), C32H41N3O6, (5b), and (R,S)-Mns-Acp-(S,R)-Mns-Acp-NMe2, C30H37N3O6, (5c) (Pms is phenyllactic acid, Acp is 1-aminocyclopentanecarboxylic acid and Mns is mandelic acid), generally adopt a beta-turn conformation in the solid state, which is stabilized by intramolecular N-H...O hydrogen bonds.	Hydrogen	623-633	CPAT1	Homo sapiens	74-77
31919301-4	2020	The molecules in the linear hexadepsipeptide amide in (S)-Pms-Acp-(S)-Pms-Acp-(S)-Pms-Acp-NMe2 acetonitrile solvate, C47H58N4O9 C2H3N, (3b), as well as in the related linear tetradepsipeptide amide (S)-Pms-Aib-(S)-Pms-Aib-NMe2, C28H37N3O6, (5a), the diastereoisomeric mixture (S,R)-Pms-Acp-(R,S)-Pms-Acp-NMe2/(R,S)-Pms-Acp-(R,S)-Pms-Acp-NMe2 (1:1), C32H41N3O6, (5b), and (R,S)-Mns-Acp-(S,R)-Mns-Acp-NMe2, C30H37N3O6, (5c) (Pms is phenyllactic acid, Acp is 1-aminocyclopentanecarboxylic acid and Mns is mandelic acid), generally adopt a beta-turn conformation in the solid state, which is stabilized by intramolecular N-H...O hydrogen bonds.	Hydrogen	623-633	CPAT1	Homo sapiens	74-77
31919301-4	2020	The molecules in the linear hexadepsipeptide amide in (S)-Pms-Acp-(S)-Pms-Acp-(S)-Pms-Acp-NMe2 acetonitrile solvate, C47H58N4O9 C2H3N, (3b), as well as in the related linear tetradepsipeptide amide (S)-Pms-Aib-(S)-Pms-Aib-NMe2, C28H37N3O6, (5a), the diastereoisomeric mixture (S,R)-Pms-Acp-(R,S)-Pms-Acp-NMe2/(R,S)-Pms-Acp-(R,S)-Pms-Acp-NMe2 (1:1), C32H41N3O6, (5b), and (R,S)-Mns-Acp-(S,R)-Mns-Acp-NMe2, C30H37N3O6, (5c) (Pms is phenyllactic acid, Acp is 1-aminocyclopentanecarboxylic acid and Mns is mandelic acid), generally adopt a beta-turn conformation in the solid state, which is stabilized by intramolecular N-H...O hydrogen bonds.	Hydrogen	623-633	CPAT1	Homo sapiens	74-77
31919301-4	2020	The molecules in the linear hexadepsipeptide amide in (S)-Pms-Acp-(S)-Pms-Acp-(S)-Pms-Acp-NMe2 acetonitrile solvate, C47H58N4O9 C2H3N, (3b), as well as in the related linear tetradepsipeptide amide (S)-Pms-Aib-(S)-Pms-Aib-NMe2, C28H37N3O6, (5a), the diastereoisomeric mixture (S,R)-Pms-Acp-(R,S)-Pms-Acp-NMe2/(R,S)-Pms-Acp-(R,S)-Pms-Acp-NMe2 (1:1), C32H41N3O6, (5b), and (R,S)-Mns-Acp-(S,R)-Mns-Acp-NMe2, C30H37N3O6, (5c) (Pms is phenyllactic acid, Acp is 1-aminocyclopentanecarboxylic acid and Mns is mandelic acid), generally adopt a beta-turn conformation in the solid state, which is stabilized by intramolecular N-H...O hydrogen bonds.	Hydrogen	623-633	CPAT1	Homo sapiens	74-77
31919301-4	2020	The molecules in the linear hexadepsipeptide amide in (S)-Pms-Acp-(S)-Pms-Acp-(S)-Pms-Acp-NMe2 acetonitrile solvate, C47H58N4O9 C2H3N, (3b), as well as in the related linear tetradepsipeptide amide (S)-Pms-Aib-(S)-Pms-Aib-NMe2, C28H37N3O6, (5a), the diastereoisomeric mixture (S,R)-Pms-Acp-(R,S)-Pms-Acp-NMe2/(R,S)-Pms-Acp-(R,S)-Pms-Acp-NMe2 (1:1), C32H41N3O6, (5b), and (R,S)-Mns-Acp-(S,R)-Mns-Acp-NMe2, C30H37N3O6, (5c) (Pms is phenyllactic acid, Acp is 1-aminocyclopentanecarboxylic acid and Mns is mandelic acid), generally adopt a beta-turn conformation in the solid state, which is stabilized by intramolecular N-H...O hydrogen bonds.	Hydrogen	623-633	CPAT1	Homo sapiens	74-77
31919301-4	2020	The molecules in the linear hexadepsipeptide amide in (S)-Pms-Acp-(S)-Pms-Acp-(S)-Pms-Acp-NMe2 acetonitrile solvate, C47H58N4O9 C2H3N, (3b), as well as in the related linear tetradepsipeptide amide (S)-Pms-Aib-(S)-Pms-Aib-NMe2, C28H37N3O6, (5a), the diastereoisomeric mixture (S,R)-Pms-Acp-(R,S)-Pms-Acp-NMe2/(R,S)-Pms-Acp-(R,S)-Pms-Acp-NMe2 (1:1), C32H41N3O6, (5b), and (R,S)-Mns-Acp-(S,R)-Mns-Acp-NMe2, C30H37N3O6, (5c) (Pms is phenyllactic acid, Acp is 1-aminocyclopentanecarboxylic acid and Mns is mandelic acid), generally adopt a beta-turn conformation in the solid state, which is stabilized by intramolecular N-H...O hydrogen bonds.	Hydrogen	623-633	CPAT1	Homo sapiens	74-77
31707537-9	2020	This review is on the structural and functional aspects of plant histone chaperone families, specifically those which bind to H2A-H2B, viz nucleosome assembly protein (NAP), nucleoplasmin (NPM), and facilitates chromatin transcription (FACT).	Hydrogen	126-133	nucleophosmin 1	Homo sapiens	174-187
31707537-9	2020	This review is on the structural and functional aspects of plant histone chaperone families, specifically those which bind to H2A-H2B, viz nucleosome assembly protein (NAP), nucleoplasmin (NPM), and facilitates chromatin transcription (FACT).	Hydrogen	126-133	nucleophosmin 1	Homo sapiens	189-192
31735420-9	2020	Thermodynamic parameters demonstrated that MBP-aD interacted with anti-HBsAg and PAMAM G4, through van der Waals and hydrogen bonding.	Hydrogen	117-125	myelin basic protein	Homo sapiens	43-46
31775157-8	2020	SSRP1 also contributes to DNA binding, and can assume two conformations, depending on whether a second H2A-H2B dimer is present.	Hydrogen	103-110	structure specific recognition protein 1	Homo sapiens	0-5
33731981-4	2020	1H NMR titrations show that P1 and P2 are poor hosts toward hydrophobic (di)cations 6 - 11 (P1: Ka = 375-1400 M-1; P2: Ka = 1950-19800 M-1) compared to Tet1 and Tet2 (Tet1: Ka = 3.09 x 106 to 4.69 x 108 M-1; Tet2: Ka = 4.59 x 108 to 1.30 x 1010 M-1).	Hydrogen	0-2	tet methylcytosine dioxygenase 2	Homo sapiens	161-165
33731981-4	2020	1H NMR titrations show that P1 and P2 are poor hosts toward hydrophobic (di)cations 6 - 11 (P1: Ka = 375-1400 M-1; P2: Ka = 1950-19800 M-1) compared to Tet1 and Tet2 (Tet1: Ka = 3.09 x 106 to 4.69 x 108 M-1; Tet2: Ka = 4.59 x 108 to 1.30 x 1010 M-1).	Hydrogen	0-2	tet methylcytosine dioxygenase 2	Homo sapiens	208-212
31514881-2	2020	The incorporation of amino groups (hydrogen bonding sites) into hydrophobic MON-NH2 networks led to their good enrichment for four typical EDCs bisphenol A (BPA), 4-alpha-cumylphenol (4-alpha-CP), 4-tert-octylphenol (4-t-OP) and 4-nonylphenol (4-NP) relying on the pre-designed hydrogen bonding, pi-pi and hydrophobic interactions.	Hydrogen	35-43	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	186-194
31843910-6	2019	Using a mouse model of MHC I-dependent (H-2Dk) virus immunity, we discovered that NK cells depend on the Ly49G2 inhibitory self-receptor to mediate virus control, which coincided with host survival during murine cytomegalovirus infection.	Hydrogen	40-45	killer cell lectin-like receptor, subfamily A, member 7	Mus musculus	105-111
31725288-6	2019	Together, 41 is a novel Hsp90-Cdc37 disruptor by binding to Cdc37 (hydrogen bond and/or covalent bond).	Hydrogen	67-75	cell division cycle 37, HSP90 cochaperone	Homo sapiens	30-35
31725288-6	2019	Together, 41 is a novel Hsp90-Cdc37 disruptor by binding to Cdc37 (hydrogen bond and/or covalent bond).	Hydrogen	67-75	cell division cycle 37, HSP90 cochaperone	Homo sapiens	60-65
31693378-5	2019	As a proof-of-concept demonstration, the 2D Ni-MOF@Pt hybrid with well-defined interfaces is applied to boost the electrochemical hydrogen evolution reaction (HER) and delivers decent electrocatalytic activity under both acidic and alkaline conditions.	Hydrogen	130-138	lysine acetyltransferase 8	Homo sapiens	47-50
31729224-13	2019	The photogenerated MV+  by the two hybrid photosystems is used to catalyze H2-evolution in the presence of Pt nanoparticle catalysts, and to mediate the reduction of NADP+ to NADPH in the presence of ferredoxin-NADP+ reductase, FNR.	Hydrogen	75-77	ferredoxin reductase	Homo sapiens	200-226
31755485-6	2019	Therefore, the dual-defective SnS2 monolayer can serve as an efficient photocatalyst for overall water splitting to produce hydrogen fuel.	Hydrogen	124-132	sodium voltage-gated channel alpha subunit 11	Homo sapiens	30-34
31690920-3	2019	To demonstrate the applicability of RMCF to reactivity, we link the kinetic energy distribution within a reactive mode with the asynchronicity (eta) in C-H bond activation, as they both evolve in a series of coupled proton-electron transfer (CPET) reactions between FeIVO oxidants and 1,4-cyclohexadiene.	Hydrogen	152-155	endothelin receptor type A	Homo sapiens	144-147
31640987-9	2019	Employing hydrogen-deuterium exchange MS, we identified an MA-MA interface in the MA trimer that is implicated in Gag assembly and Env incorporation.	Hydrogen	10-18	Pr55(Gag)	Human immunodeficiency virus 1	114-117
31713427-0	2019	Influence of Hydrogen Bonding Between Ions of Like Charge on the Ionic Liquid Interfacial Structure at a Mica Surface.	Hydrogen	13-21	MHC class I polypeptide-related sequence A	Homo sapiens	105-109
31651920-2	2019	By using a cross-linking reagent capable of forming hydrogen bonds and disulfide linkages within the gel network, we were able to produce mucin-based hydrogels with viscoelastic properties similar to natural mucus as measured by bulk rheology.	Hydrogen	52-60	LOC100508689	Homo sapiens	138-143
31418487-4	2019	Although, shape complementarity clearly dominated this binding model and aptamers are known to be somewhat flexible, the model demonstrates hydrogen bond stabilization within each of the two different aptamers and between the aptamers and the BNP target, thus suggesting a strong binding and high affinity sandwich assay that matches the author"s former published assay results (Bruno et al., Microchem.	Hydrogen	140-148	natriuretic peptide B	Homo sapiens	243-246
31781954-5	2019	Among the various compositions of Cux@NC, the electrode modified with Cu3@NC showed the strongest reduction peak, typically at a potential of -0.30 V vs. reversible hydrogen electrode (RHE).	Hydrogen	165-173	cut like homeobox 1	Homo sapiens	34-37
32610453-0	2020	A DVD-MoS2/Ag2S/Ag Nanocomposite Thiol-Conjugated with Porphyrins for an Enhanced Light-Mediated Hydrogen Evolution Reaction.	Hydrogen	97-105	angiotensin II receptor type 1	Homo sapiens	11-15
32610453-1	2020	We have recently demonstrated in a previous work an appreciable photoelectrocatalytic (PEC) behavior towards hydrogen evolution reaction (HER) of a MoS2/Ag2S/Ag nanocomposite electrochemically deposited on a commercial writable Digital Versatile Disc (DVD), consisting therefore on an interesting strategy to convert a common waster product in an added-value material.	Hydrogen	109-117	angiotensin II receptor type 1	Homo sapiens	153-157
32590364-6	2020	Moreover, it is discovered that when the IL is hydrophilic, its hydrogen bonding ability can be utilized to designate an interaction site on MOF"s ligand structure which will lead to a lower reduction in thermal stability limits.	Hydrogen	64-72	lysine acetyltransferase 8	Homo sapiens	141-144
32433911-5	2020	Signal transmission between the allosteric and catalytic sites take place through intramolecular aromatic interactions and a hydrogen bond network that involves residues and water molecules of the MIF solvent channel.	Hydrogen	125-133	macrophage migration inhibitory factor	Homo sapiens	197-200
32448098-7	2021	The nCoV RBD was found binding to ACE2 receptor with 11 hydrogen bonds and 1 salt bridge.	Hydrogen	56-64	angiotensin converting enzyme 2	Homo sapiens	34-38
32448098-9	2021	Based on the hydrogen bonding, RMSD and RMSF, total and potential energies, the nCoV was found binding to ACE2 receptor with higher stability and rigidity.	Hydrogen	13-21	angiotensin converting enzyme 2	Homo sapiens	106-110
32695440-4	2020	The crystal structure displays an O-H O hydrogen bond between a mu2-OH group and an acetone solvent mol-ecule.	Hydrogen	40-48	adaptor related protein complex 1 subunit mu 2	Homo sapiens	64-67
31558672-3	2020	In the present study, Hydrogen- deuterium exchange mass spectrometry was employed to gain insight into the FVIII binding region on Von Willebrand Factor.	Hydrogen	22-30	coagulation factor VIII	Homo sapiens	107-112
32392076-5	2020	The downfield shift of RAF amide proton, resolved under UF-MAS, and its correlations with aliphatic protons of PVP, serve as a strong evidence of the existence of intermolecular hydrogen bonding.	Hydrogen	178-186	zinc fingers and homeoboxes 2	Homo sapiens	23-26
32292127-0	2020	Hydrogen improves cell viability partly through inhibition of autophagy and activation of PI3K/Akt/GSK3beta signal pathway in a microvascular endothelial cell model of traumatic brain injury.	Hydrogen	0-8	glycogen synthase kinase 3 alpha	Homo sapiens	99-107
32514327-5	2020	Consistent with experimental data, the acidic tail was predicted to adopt an extended conformation that allows it to make a range of hydrogen-bonding and electrostatic interactions with the box-like domains that stabilize the overall structure of HMGB1.	Hydrogen	133-141	high mobility group box 1	Homo sapiens	247-252
32227621-6	2020	FeP-CoMoP HNSs reveal super activity for hydrogen evolution reaction (HER) with an ultralow cathodic overpotential of 33 mV at 10 mA cm -2 and a Tafel slope of 51 mV dec -1 .	Hydrogen	41-49	deleted in esophageal cancer 1	Homo sapiens	166-172
32371991-2	2020	Here we quantified these dynamic equilibria in the beta1-adrenergic receptor in its apo form and seven ligand complexes using 1H/15N NMR spectroscopy.	Hydrogen	126-128	adrenoceptor beta 1	Homo sapiens	51-76
32371996-2	2020	Studies have shown that serine with ability to form a hydrogen bond in loop C of some insect nAChR alpha subunits and glutamate with a negative charge at the corresponding position in vertebrate nAChRs may contribute to enhancing and reducing the neonicotinoid actions, respectively.	Hydrogen	54-62	cholinergic receptor nicotinic beta 3 subunit	Gallus gallus	93-98
31667482-0	2019	MOF-derived cobalt-nickel phosphide nanoboxes as electrocatalysts for the hydrogen evolution reaction.	Hydrogen	74-82	lysine acetyltransferase 8	Homo sapiens	0-3
31667482-3	2019	Herein, we adopt a unique MOF-derived strategy to synthesize transition metal phosphide nanoboxes which can be employed as electrocatalysts for the hydrogen evolution reaction.	Hydrogen	148-156	lysine acetyltransferase 8	Homo sapiens	26-29
31679334-5	2019	Specifically, the hydrogen plasma engraved Co-MOF-74 shows enhanced catalytic activity of oxygen evolution reaction, which exhibits a low overpotential (337 mV at 15 mA cm-2), high turnover frequency (0.0219 s-1), and large mass activity (54.3 A g-1).	Hydrogen	18-26	lysine acetyltransferase 8	Homo sapiens	43-52
31617515-3	2019	Isotope labeling studies along with B3LYP geometry optimization DFT modeling studies indicate a mechanism involving a Re-H-Re bridging complex that leads to a dimeric Re-Re(eta2-H2) state prior to dissociating H2 gas.	Hydrogen	178-180	carboxylesterase 1	Homo sapiens	118-122
31661237-5	2019	Thus, the uniquely-formed stable carbon network achieves active hydrogen evolution with a Tafel slope of 39 mV dec^-1 and a double layer capacitance of 12.41 mF cm^-2, which breaks the conventional limit of graphene-based catalysis, suggesting a promising strategy for metal-free catalyst engineering and hydrogen production.	Hydrogen	64-72	deleted in esophageal cancer 1	Homo sapiens	111-117
31661237-5	2019	Thus, the uniquely-formed stable carbon network achieves active hydrogen evolution with a Tafel slope of 39 mV dec^-1 and a double layer capacitance of 12.41 mF cm^-2, which breaks the conventional limit of graphene-based catalysis, suggesting a promising strategy for metal-free catalyst engineering and hydrogen production.	Hydrogen	305-313	deleted in esophageal cancer 1	Homo sapiens	111-117
31693344-7	2019	The latter mixture can also react with HS-, giving HNO and HS2- (hydrogen disulfide), a S0(sulfane)-transfer reagent toward {(H)SNO}, leading to SSNO-, a moderately stable species that slowly decomposes in aqueous sulfide-containing solutions in the minute-hour time scale, depending on [O2].	Hydrogen	65-83	strawberry notch homolog 1	Homo sapiens	128-131
31621324-3	2019	As a model application, the open-shell ALMO-MP2-EDA is applied to study the first solvation step of halogenated benzene radical cations, where both halogen- and hydrogen-bonded isomers are possible.	Hydrogen	161-169	ectodysplasin A	Homo sapiens	48-51
31698846-8	2019	By analyzing structural deviations, energetic components, and the number of hydrogen bonds in the interface region, we propose that the KIRA inhibitors act at an early stage of IRE1 activation by interfering with IRE1 face-to-face dimer formation thus disabling the activation of the RNase domain.	Hydrogen	76-84	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	177-181
31698846-8	2019	By analyzing structural deviations, energetic components, and the number of hydrogen bonds in the interface region, we propose that the KIRA inhibitors act at an early stage of IRE1 activation by interfering with IRE1 face-to-face dimer formation thus disabling the activation of the RNase domain.	Hydrogen	76-84	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	213-217
31472452-14	2019	Molecular docking indicated that hydrogen bonds and hydrophobic interactions contributed to the interaction between PFASs and UGT isoforms.	Hydrogen	33-41	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	126-129
31433121-6	2019	More interestingly, the class-II drugs established a highly coordinated binding at the DRD2 active site with a pertinent and recurrent involvement of Asp114 via strong hydrogen interactions.	Hydrogen	168-176	dopamine receptor D2	Homo sapiens	87-91
31621701-2	2019	Molecular modelling further established the relationship between the evolutive water-hydrogen bonded network and the "electrical" isotherm for this water-mediated proton conducting MOF.	Hydrogen	85-93	lysine acetyltransferase 8	Homo sapiens	181-184
31576854-1	2019	Herein, an ultrasensitive electrochemical biosensor is proposed for the quantification of the Flu A virus biomarker DNA (fDNA), and is based on loop-mediated isothermal amplification-generated hydrogen ions (LAMP-H+) which induce the formation of the dimer i-motif structure (DiMS) for signal transduction, coupled with exonuclease III (ExoIII)-assisted DNA walking for signal dual-amplification.	Hydrogen	193-201	lysosomal associated membrane protein 3	Homo sapiens	208-212
31614645-7	2019	Therefore, the variation of hydrogen bond competition can be supplemented by the intensity ratio of PHW/FHW ((IC2 + IC3)/IC1).	Hydrogen	28-36	dynein cytoplasmic 1 intermediate chain 2	Homo sapiens	110-113
31350216-3	2019	The protective mechanism of hydrogen molecules is based on selectively reducing highly strong oxidants in cells, thereby reducing inflammation and decreasing the contents of MDA, FOXO3a, and other pathways that result in flap necrosis.	Hydrogen	28-36	forkhead box O3	Rattus norvegicus	179-185
31533957-6	2019	Structural comparison of the monomer and dimer revealed that a hydrogen bond network of water molecules is formed at the entry surface of the proton transfer pathway, termed the K-pathway, in monomeric CcO, whereas this network is altered in dimeric CcO.	Hydrogen	63-71	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	202-205
31533957-6	2019	Structural comparison of the monomer and dimer revealed that a hydrogen bond network of water molecules is formed at the entry surface of the proton transfer pathway, termed the K-pathway, in monomeric CcO, whereas this network is altered in dimeric CcO.	Hydrogen	63-71	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	250-253
31100687-2	2019	On this basis, the hydrogen production performance of the bimetallic sulfide CuCo2S4 (CCS-3) was compared with that of the single metal sulfides Cu31S16 and CoS2.	Hydrogen	19-27	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	86-91
31100687-3	2019	The results showed that the bimetallic sulfide CCS-3 significantly improved the photocatalytic hydrogen production performance.	Hydrogen	95-103	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	47-52
31100687-4	2019	The unique structure of the bimetallic sulfide CCS-3 made the photocatalytic activity of H2 2.47 times and 178.08 times higher than that of Cu31S16 and CoS2, respectively.	Hydrogen	89-91	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	47-52
31100687-5	2019	In addition, the hydrogen production activity in CCS-3 was also very stable after XRD comparison before and after the reaction.	Hydrogen	17-25	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	49-54
31158420-1	2019	Novel polymer-drug conjugates (CNC) were prepared from carboxymethyl chitosan (CMCS) and norcantharidin (NCTD) via amidation reaction and characterized by FTIR and 1H NMR spectroscopy.	Hydrogen	164-166	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	31-34
31063984-5	2019	When lattice constant a increases to 3.17 A, monolayer 1H-TcN2 undergoes N-N nonbonding-bonding transition at which the distance between the N atoms d N-N suddenly drops by almost 25%.	Hydrogen	55-57	transcobalamin 2	Homo sapiens	58-62
31063984-6	2019	In particular, due to the bonding between two neighboring N atoms, the magnetic moment of N atoms in 1H-TcN2 are quenched and the ground state transfers to non-magnetic.	Hydrogen	101-103	transcobalamin 2	Homo sapiens	104-108
31294426-4	2019	Solution 1H and 13C NMR studies of [Pd(C^N)([9]aneS2O)](PF6) complexes demonstrate complicated [9]aneS2O behavior at room temperature.	Hydrogen	9-11	sperm associated antigen 17	Homo sapiens	56-59
30889560-0	2019	A high-performance hydrogen sensor based on a reverse-biased MoS2/GaN heterojunction.	Hydrogen	19-27	gigaxonin	Homo sapiens	66-69
31100396-3	2019	Based on dynamic rheological analysis, ZC-3 solution showed the highest G" value and the crossover point at the lowest frequency, representing the strongest entanglement and hydrogen bonding.	Hydrogen	174-182	misshapen like kinase 1	Homo sapiens	39-43
31195794-4	2019	As a result, WC@NC demonstrates remarkable hydrogen evolution reaction (HER) electrocatalytic performance with overpotentials of 127 and 141 mV at a current density of 10 mA cm-2 and Tafel slopes of 56.3 and 78.7 mV dec-1 in acid and alkaline media, respectively.	Hydrogen	43-51	deleted in esophageal cancer 1	Homo sapiens	216-221
31116484-5	2019	The system has a positively shifted onset potential of hydrogen evolution reaction (HER) by 0.4 V compared to a typical HER under alkaline conditions and facile HER kinetics with low Tafel slope of 34 mV dec-1 .	Hydrogen	55-63	deleted in esophageal cancer 1	Homo sapiens	204-209
30978352-11	2019	The binding conformation of YAP/TAZ distorted by decreased non-polar interaction and the lost hydrogen bonds would lead to reduced interaction activity.	Hydrogen	94-102	yes-associated protein 1	Mus musculus	28-31
31214674-2	2019	Also, 1T SnS2 exhibited advantages over commercial SnS2 (mixed with 1T and 1H phases) in cell resistance and lithium-storage performance.	Hydrogen	75-77	sodium voltage-gated channel alpha subunit 11	Homo sapiens	9-13
30058436-5	2019	Moreover, it is observed that BRD9 is anchored by the formation of a stable hydrogen bond between the carbonyl of the inhibitors and the residue Asn100 (at BC loop), and a strong pi-pi stacking interaction formed between the residue Tyr106 (at BC loop) and the inhibitors.	Hydrogen	76-84	bromodomain containing 9	Homo sapiens	30-34
31441411-0	2019	[Effects of hydrogen on lung injury in wild-type and Nrf2 gene knockout mice: relationship with Nrf2/HO-1/HMGB1 pathway].	Hydrogen	12-20	high mobility group box 1	Mus musculus	106-111
31441411-15	2019	CONCLUSIONS: H2 inhibits lung injury in septic mice through Nrf2/HO-1/HMGB1 pathway.	Hydrogen	13-15	high mobility group box 1	Mus musculus	70-75
31145582-0	2019	Ag2S/MoS2 Nanocomposites Anchored on Reduced Graphene Oxide: Fast Interfacial Charge Transfer for Hydrogen Evolution Reaction.	Hydrogen	98-106	angiotensin II receptor type 1	Homo sapiens	0-4
31145582-5	2019	Compared with the bare MoS2 and MoS2/RGO, the Ag2S/MoS2 anchored on the RGO surface (the ternary system Ag2S/MoS2/RGO) demonstrated a high catalytic activity toward hydrogen evolution reaction (HER).	Hydrogen	165-173	angiotensin II receptor type 1	Homo sapiens	46-50
31145582-5	2019	Compared with the bare MoS2 and MoS2/RGO, the Ag2S/MoS2 anchored on the RGO surface (the ternary system Ag2S/MoS2/RGO) demonstrated a high catalytic activity toward hydrogen evolution reaction (HER).	Hydrogen	165-173	angiotensin II receptor type 1	Homo sapiens	104-108
31091075-4	2019	Featuring densely exposed and periodic Cu2+ active sites (2.1 x 106 per mum2), as well as ultrathin nature (5 nm) and significant pores (18 A), this nanosheet demonstrated remarkable performance of electrocatalytic hydrogen evolution.	Hydrogen	215-223	trafficking protein particle complex subunit 1	Homo sapiens	72-76
30920109-1	2019	A hydrogen-bonding donor-acceptor system, [Co2 Fe2 (bpy*)4 (CN)6 (tp*)2 ](PF6 )2  2ABA 4BN 2PE (1 solv ), was prepared by co-crystallization of an external stimuli-responsive cyanide-bridged tetranuclear [Co2 Fe2 ] complex and bifunctional hydrogen-bonding donors, p-aminobenzoic acid.	Hydrogen	2-10	sperm associated antigen 17	Homo sapiens	74-77
30920109-1	2019	A hydrogen-bonding donor-acceptor system, [Co2 Fe2 (bpy*)4 (CN)6 (tp*)2 ](PF6 )2  2ABA 4BN 2PE (1 solv ), was prepared by co-crystallization of an external stimuli-responsive cyanide-bridged tetranuclear [Co2 Fe2 ] complex and bifunctional hydrogen-bonding donors, p-aminobenzoic acid.	Hydrogen	240-248	sperm associated antigen 17	Homo sapiens	74-77
30982633-7	2019	Small-angle X-ray scattering and hydrogen-deuterium exchange mass spectrometry analyses determined the existence of a stable heterodimeric complex in solution and provide evidence that binding of Spx to YjbH reduces the overall conformational flexibility of Spx.	Hydrogen	33-41	spexin hormone	Homo sapiens	196-199
30419364-4	2019	The mesoporous structure within the MBG microspheres and the hydrogen bonding between the scaffolds and UA drugs made the MBG/CS/UA scaffolds have controlled drug release performances.	Hydrogen	61-69	citrate synthase	Homo sapiens	126-128
30968189-6	2019	To explore the alternate hypothesis, we report here the in vitro binding of uncharged tRNA to RelA in the absence of ribosome using formaldehyde cross-linking, fluorescence spectroscopy, surface plasmon resonance, size-exclusion chromatography, and hydrogen-deuterium exchange mass spectrometry.	Hydrogen	249-257	RELA proto-oncogene, NF-kB subunit	Homo sapiens	94-98
32375375-1	2020	The objective of the present study was to determine the physiological role of voltage-gated hydrogen channels 1 (HVCN1 channels) during in vitro capacitation of pig spermatozoa.	Hydrogen	92-100	hydrogen voltage gated channel 1	Sus scrofa	113-118
31216515-6	2019	The resultant membrane, the mica supported IL membrane (M-SILM), has about 80 GPU for CO2 permeance, and selectivity for CO2/H2, CO2/CH4 and CO2/N2 of 7.7, 28.6 and 87, respectively.	Hydrogen	125-127	MHC class I polypeptide-related sequence A	Homo sapiens	28-32
31101996-14	2019	RESULTS: KS1 was synthesized and characterized using 1H NMR spectra.	Hydrogen	53-55	zinc finger protein 382	Homo sapiens	9-12
31238073-9	2019	The interactions within the toxin-pep5 complex were due to hydrogen bond and hydrophobic interaction.	Hydrogen	59-67	VPS11 core subunit of CORVET and HOPS complexes	Homo sapiens	34-38
32365525-5	2020	Caspase 8 was determined to interact with rutaecarpine through five amino acid residues, specifically Thr337, Lys353, Val354, Phe355, and Phe356, and two hydrogen bonds (ligand: H35-A: LYS353:O and A:PHE355: N-ligand: N5).	Hydrogen	154-162	caspase 8	Homo sapiens	0-9
31407917-6	2019	The redox species generated by the photosensitizer-aptamer/electron acceptor supramolecular systems mediate the ferredoxin-NADP+ reductase, FNR, catalyzed synthesis of NADPH, and the Pt-nanoparticle-catalyzed evolution of hydrogen (H2).	Hydrogen	222-230	ferredoxin reductase	Homo sapiens	112-138
30900285-2	2019	Hydrogen in gaseous form is known to be a strong reducing agent and can potentially react with the secondary building units of a MOF and decompose the porous framework structure.	Hydrogen	0-8	lysine acetyltransferase 8	Homo sapiens	129-132
30900285-3	2019	Moreover, rapid pressure swings expected in vehicular hydrogen storage could create significant mechanical stresses within MOF crystals that cause partial or complete pore collapse.	Hydrogen	54-62	lysine acetyltransferase 8	Homo sapiens	123-126
30844566-6	2019	It is found that Fe/N-HCS improve the hydrogen evolution reaction activity after electrodeposition trace quantity of Pt, which shows 170 mV of overpotential to deliver 100 mA cm-2.	Hydrogen	38-46	holocarboxylase synthetase	Homo sapiens	22-25
30951745-7	2019	Furthermore, relative higher levels of LC3-II/I ratio and Beclin-1, with decreased expression of p62, were found after H2 administrated.	Hydrogen	119-121	beclin 1	Rattus norvegicus	58-66
30951745-7	2019	Furthermore, relative higher levels of LC3-II/I ratio and Beclin-1, with decreased expression of p62, were found after H2 administrated.	Hydrogen	119-121	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	97-100
32354206-5	2020	Comparison between protein solvent interactions and the hydrophobicity of these two forms of serine proteases showed that THM had more burial of nonpolar areas, and less protein solvent hydrogen bonds (HBs), indicating that solvent entropy maximization and mobility may play a significant role in THM"s adaption to high temperature environments.	Hydrogen	186-194	THM	Homo sapiens	122-125
30951745-10	2019	H2 could inhibit the activation of p38 and JNK, suggesting H2 played an active part in resisting renal injury via MAPK.	Hydrogen	0-2	mitogen activated protein kinase 14	Rattus norvegicus	35-38
30951745-10	2019	H2 could inhibit the activation of p38 and JNK, suggesting H2 played an active part in resisting renal injury via MAPK.	Hydrogen	59-61	mitogen activated protein kinase 14	Rattus norvegicus	35-38
30951745-11	2019	SIGNIFICANCE: Taken together, our study reveals that H2 can ameliorate CIH-induced kidney injury by decreasing endoplasmic reticulum stress and activating autophagy through inhibiting oxidative stress-dependent p38 and JNK MAPK activation.	Hydrogen	53-55	mitogen activated protein kinase 14	Rattus norvegicus	211-214
31345030-5	2019	With the aid of the absolutely localized molecular orbital energy decomposition analysis (ALMO EDA), this structure-based partitioning is found to largely correlate with the character of different many-body interactions, such as cooperative and anticooperative hydrogen bonding, within each fragment.	Hydrogen	261-269	ectodysplasin A	Homo sapiens	95-98
32007740-5	2020	To generate a current density of 10 mA cm-2, CoSe2@N/C-CNT exerted as low as overpotential (eta) of 185 mV vs. RHE (reversible hydrogen electrode) and 340 mV vs. RHE for HER and OER, the corresponding Tafel slopes were 98 and 107 mV dec-1 respectively.	Hydrogen	127-135	endothelin receptor type A	Homo sapiens	92-95
30198396-8	2019	Enzyme-inhibitor complex is stabilized by intermolecular hydrogen bonding network, electrostatic and hydrophobic interactions which mostly involve constituent amino acid residues of the hDPP III substrate binding subsites S1, S1", S2, S2" and S3".	Hydrogen	57-65	dipeptidyl peptidase 3	Homo sapiens	186-194
31040202-12	2019	Therefore, we conclude that Tet and the CCND1/CDK4 compound could form hydrogen bonds and a stable compound structure, which can inhibit colon cancer cells proliferation by regulating CCND1/CDK4 compound and its downstream proteins phosphorylated Rb (p-Rb).	Hydrogen	71-79	cyclin D1	Homo sapiens	40-45
31040202-12	2019	Therefore, we conclude that Tet and the CCND1/CDK4 compound could form hydrogen bonds and a stable compound structure, which can inhibit colon cancer cells proliferation by regulating CCND1/CDK4 compound and its downstream proteins phosphorylated Rb (p-Rb).	Hydrogen	71-79	cyclin dependent kinase 4	Homo sapiens	46-50
31040202-12	2019	Therefore, we conclude that Tet and the CCND1/CDK4 compound could form hydrogen bonds and a stable compound structure, which can inhibit colon cancer cells proliferation by regulating CCND1/CDK4 compound and its downstream proteins phosphorylated Rb (p-Rb).	Hydrogen	71-79	cyclin D1	Homo sapiens	184-189
31040202-12	2019	Therefore, we conclude that Tet and the CCND1/CDK4 compound could form hydrogen bonds and a stable compound structure, which can inhibit colon cancer cells proliferation by regulating CCND1/CDK4 compound and its downstream proteins phosphorylated Rb (p-Rb).	Hydrogen	71-79	cyclin dependent kinase 4	Homo sapiens	190-194
30973014-3	2019	Systematic changes in MOF 13C NMR peak positions and 1H NMR line widths, as well as dramatic reductions in the MOF 1H T1rho relaxation times, are observed as the PEO content increases, and when the pores have been filled, a further increase in PEO results in the formation of semicrystalline PEO outside the UiO-66 particles.	Hydrogen	115-117	lysine acetyltransferase 8	Homo sapiens	111-114
31576228-4	2019	While AIMP2GST and EPRSGST interact via conventional GST heterodimerization, DRS strongly interacts with AIMP2GST via hydrogen bonds between the alpha7-beta9 loop of DRS and the beta2-alpha2 loop of AIMP2GST, where Ser156 of AIMP2GST is essential for the assembly.	Hydrogen	118-126	sushi repeat containing protein X-linked	Homo sapiens	77-80
31576228-4	2019	While AIMP2GST and EPRSGST interact via conventional GST heterodimerization, DRS strongly interacts with AIMP2GST via hydrogen bonds between the alpha7-beta9 loop of DRS and the beta2-alpha2 loop of AIMP2GST, where Ser156 of AIMP2GST is essential for the assembly.	Hydrogen	118-126	aminoacyl tRNA synthetase complex interacting multifunctional protein 2	Homo sapiens	105-110
32141454-1	2020	Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) is a well-established technique for structural analysis of proteins.	Hydrogen	0-8	highly divergent homeobox	Homo sapiens	58-61
31576228-4	2019	While AIMP2GST and EPRSGST interact via conventional GST heterodimerization, DRS strongly interacts with AIMP2GST via hydrogen bonds between the alpha7-beta9 loop of DRS and the beta2-alpha2 loop of AIMP2GST, where Ser156 of AIMP2GST is essential for the assembly.	Hydrogen	118-126	sushi repeat containing protein X-linked	Homo sapiens	166-169
31576228-4	2019	While AIMP2GST and EPRSGST interact via conventional GST heterodimerization, DRS strongly interacts with AIMP2GST via hydrogen bonds between the alpha7-beta9 loop of DRS and the beta2-alpha2 loop of AIMP2GST, where Ser156 of AIMP2GST is essential for the assembly.	Hydrogen	118-126	aminoacyl tRNA synthetase complex interacting multifunctional protein 2	Homo sapiens	105-110
30942073-12	2019	Hydrogen-bonded adducts of HO2 with the precursors, HO2 CH3OH and HO2 CH3CHO, played a role at lower temperatures; as part of this work, rate enhancements of the HO2 self-reaction due to reactions of the adducts with HO2 were also measured.	Hydrogen	0-8	heme oxygenase 2	Homo sapiens	27-30
30942073-12	2019	Hydrogen-bonded adducts of HO2 with the precursors, HO2 CH3OH and HO2 CH3CHO, played a role at lower temperatures; as part of this work, rate enhancements of the HO2 self-reaction due to reactions of the adducts with HO2 were also measured.	Hydrogen	0-8	heme oxygenase 2	Homo sapiens	52-55
31335149-2	2019	In the presence of HS- in aqueous solution, the stochastic collision and adsorption of Ag nanoparticles at a Au microelectrode initiates the partial anodic transformation of Ag to Ag2S at each particle.	Hydrogen	19-21	angiotensin II receptor type 1	Homo sapiens	180-184
31440160-13	2019	Furthermore, pretreatment with hydrogen resulted in cardioprotection during septic cardiomyopathy via inhibiting the expression of pro-inflammatory cytokines TNFalpha, IL-1beta, and IL-18; suppressing the phosphorylation of ERK1/2, p38, and JNK; and reducing the nuclear translocation of NF-kappaB and the expression of TLR4 by LPS.	Hydrogen	31-39	interleukin 18	Mus musculus	182-187
30877542-2	2019	The AT-HBP was characterized by Fourier transformed infrared (FTIR), dynamic light scattering (DLS), and proton nuclear magnetic resonance (1H NMR) analysis.	Hydrogen	140-142	heme binding protein 1	Homo sapiens	7-10
31463759-0	2020	Complete 1H, 13C, 15N resonance assignments and secondary structure of the Vpr binding region of hHR23A (residues 223-363).	Hydrogen	9-11	RAD23 homolog A, nucleotide excision repair protein	Homo sapiens	97-103
30665156-10	2019	The hit compounds interacted with POP effectively via hydrogen bonds with important active site residues along with hydrophobic interactions.	Hydrogen	54-62	prolyl endopeptidase	Homo sapiens	34-37
30665156-12	2019	A potential new hydrogen bond interaction was discovered between Hit 2 with the Arg252 residue of POP.	Hydrogen	16-24	prolyl endopeptidase	Homo sapiens	98-101
31440160-13	2019	Furthermore, pretreatment with hydrogen resulted in cardioprotection during septic cardiomyopathy via inhibiting the expression of pro-inflammatory cytokines TNFalpha, IL-1beta, and IL-18; suppressing the phosphorylation of ERK1/2, p38, and JNK; and reducing the nuclear translocation of NF-kappaB and the expression of TLR4 by LPS.	Hydrogen	31-39	mitogen-activated protein kinase 3	Mus musculus	224-230
31440160-13	2019	Furthermore, pretreatment with hydrogen resulted in cardioprotection during septic cardiomyopathy via inhibiting the expression of pro-inflammatory cytokines TNFalpha, IL-1beta, and IL-18; suppressing the phosphorylation of ERK1/2, p38, and JNK; and reducing the nuclear translocation of NF-kappaB and the expression of TLR4 by LPS.	Hydrogen	31-39	mitogen-activated protein kinase 14	Mus musculus	232-235
32244587-7	2020	In addition, mutagenesis experiments showed that the residue His390 is the anchor residue for the binding to the Dap-type PGN and forms a hydrogen bond with MurNAc rather than meso-Dap, which interacts with the anchor residue Arg413 of PGRP-LCx in Drosophila.	Hydrogen	138-146	Peptidoglycan recognition protein LC	Drosophila melanogaster	236-244
31860884-4	2020	The optical properties of the as-obtained FePS3 show good light-harvesting ability, which endows it with excellent photocatalytic hydrogen evolution performance (402.4 mumol g-1 h-1) under the simulated solar illumination.	Hydrogen	130-138	sodium voltage-gated channel alpha subunit 11	Homo sapiens	42-47
31147316-8	2019	Molecular docking manifested the generation of strong hydrogen-bonding interactions of Ser116 in CYP1A1 and Ser127 in CYP1B1 with methoxy moiety of NC.	Hydrogen	54-62	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	118-124
31459857-3	2019	The in situ-synthesized CZTS/GO (I-CZTS/GO) composite is used as an efficient electrocatalyst for hydrogen evolution reaction (HER) which revealed superior electrocatalytic activity with a reduced overpotential (39.3 mV at 2 mA cm-2), Tafel slope (70 mV dec-1), a larger exchange current density of 908 mA cm-2, and charge transfer resistance (5 Omega), significantly different from pure CZTS.	Hydrogen	98-106	deleted in esophageal cancer 1	Homo sapiens	254-259
31110803-5	2019	In the crystal, C-H S and C-H O hydrogen bonds link the molecules, forming layers parallel to the ac plane.	Hydrogen	32-40	lysosomal trafficking regulator	Homo sapiens	16-29
32119520-3	2020	Taking advantage of the synergy of Fe(OH)3 and NiNH, the optimized Fe(OH)3@NiNH/NF sample shows a very promising electrocatalytic OER activity in 1 M KOH solution, requiring a very low overpotential of 212 mV vs. reversible hydrogen electrode (RHE) to deliver a geometrical catalytic current density of 100 mA cm-2 and a low Tafel slope of 49 mV dec-1.	Hydrogen	224-232	deleted in esophageal cancer 1	Homo sapiens	346-351
31271171-3	2019	Bis-HPTA forms a hydrogen bonded complex with DMF molecules, which shift the conformer equilibrium.	Hydrogen	17-25	hepatocyte growth factor	Homo sapiens	4-8
31271171-7	2019	They regenerate bis-HPTA-I by removing the intermolecular hydrogen bond and thereby they reestablish the proton transfer triggered proton transfer (PTTPT).	Hydrogen	58-66	hepatocyte growth factor	Homo sapiens	20-24
31944516-5	2020	Density functional theory calculations indicate that the in situ reconstructed Sn/SnO x interface facilitates formic acid production by optimizing the binding of the reaction intermediate HCOO* while promotes Faradaic efficiency of C 1 products by suppressing the competitive hydrogen evolution reaction, resulting in high Faradaic efficiency, current density and stability of CO 2 RR at low overpotentials.	Hydrogen	276-284	strawberry notch homolog 1	Homo sapiens	82-85
31058500-6	2019	Additionally, molecular dynamics (MD) simulations indicate that enthalpic stabilization of GDP binding compared to GTP binding originates in the backbone hydrogen bonding network of EF-Tu.	Hydrogen	154-162	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	182-187
30875216-4	2019	We show that an inhibitor analogue with a single-atom hydrogen-to-fluorine modification can selectively target a spastin allele with an engineered cysteine mutation in its active site.	Hydrogen	54-62	spastin	Homo sapiens	113-120
32226892-4	2020	Catalytic activities of Pt/PGR and RuO x /PGR for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) were evaluated using neutral 1 M Na2SO4 aqueous electrolyte, respectively.	Hydrogen	50-58	progesterone receptor	Homo sapiens	27-30
30882199-4	2019	Benefiting from their unique 2D structure and highly exposed active sites, the few-layer NbS2 nanosheets drop-casted on carbon paper exhibited excellent catalytic activity for the hydrogen evolution reaction (HER) in acid with an overpotential of 90 mV at a current density of 10 mA cm-2 and a low Tafel slope of 83 mV dec-1, which are superior to those reported for other NbS2-based HER electrocatalysts.	Hydrogen	180-188	deleted in esophageal cancer 1	Homo sapiens	319-324
31103405-3	2019	Docking simulation of compound 2 toward NAMPT using the crystal structure of the FK866-NAMPT complex (PDB code: 2GVJ) with replacing the boron atom type by the C3 atom type of carboranes predicted that the NAMPT inhibitory activity of 2c was improved by the hydrogen bond formation between the carborane amide and H191 of NAMPT.	Hydrogen	258-266	nicotinamide phosphoribosyltransferase	Homo sapiens	40-45
31103405-3	2019	Docking simulation of compound 2 toward NAMPT using the crystal structure of the FK866-NAMPT complex (PDB code: 2GVJ) with replacing the boron atom type by the C3 atom type of carboranes predicted that the NAMPT inhibitory activity of 2c was improved by the hydrogen bond formation between the carborane amide and H191 of NAMPT.	Hydrogen	258-266	nicotinamide phosphoribosyltransferase	Homo sapiens	87-92
31103405-3	2019	Docking simulation of compound 2 toward NAMPT using the crystal structure of the FK866-NAMPT complex (PDB code: 2GVJ) with replacing the boron atom type by the C3 atom type of carboranes predicted that the NAMPT inhibitory activity of 2c was improved by the hydrogen bond formation between the carborane amide and H191 of NAMPT.	Hydrogen	258-266	nicotinamide phosphoribosyltransferase	Homo sapiens	87-92
32226892-4	2020	Catalytic activities of Pt/PGR and RuO x /PGR for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) were evaluated using neutral 1 M Na2SO4 aqueous electrolyte, respectively.	Hydrogen	50-58	progesterone receptor	Homo sapiens	42-45
31103405-3	2019	Docking simulation of compound 2 toward NAMPT using the crystal structure of the FK866-NAMPT complex (PDB code: 2GVJ) with replacing the boron atom type by the C3 atom type of carboranes predicted that the NAMPT inhibitory activity of 2c was improved by the hydrogen bond formation between the carborane amide and H191 of NAMPT.	Hydrogen	258-266	nicotinamide phosphoribosyltransferase	Homo sapiens	87-92
30696771-9	2019	Hydrogen-deuterium exchange MS revealed that beta-sheets in NHERF1"s PDZ2 domain display lower deuterium uptake than those in the structurally similar PDZ1, implying that PDZ1 is more cloistered.	Hydrogen	0-8	SLC9A3 regulator 1	Homo sapiens	60-66
30590233-6	2019	The optimal ternary catalyst Os-Ag-Si with mass ratio of 15:15:70 (Os:Ag:Si) was synthesized by a facile SiH bond reduction method, which shows superior hydrogen evolution reaction performance with a low Tafel slope of 40 mV dec-1.	Hydrogen	153-161	deleted in esophageal cancer 1	Homo sapiens	225-230
32039429-0	2020	MOF-derived electrocatalysts for oxygen reduction, oxygen evolution and hydrogen evolution reactions.	Hydrogen	72-80	lysine acetyltransferase 8	Homo sapiens	0-3
31785324-0	2020	The intrinsic stability of H2B-ubiquitylated nucleosomes and their in vitro assembly/disassembly by histone chaperone NAP1.	Hydrogen	27-30	nucleosome assembly protein 1-like 1	Mus musculus	118-122
30793148-1	2019	A series of novel (NHC)PdCl2-PR3 complexes were synthesized and fully characterized by 1H, 13C, 31P NMR and FT-IR spectroscopy.	Hydrogen	87-89	proteinase 3	Homo sapiens	29-32
30828707-4	2019	It is found that hydrogen vacancies mainly contribute to the redshift of the measured absorption edges of both KDP and ADP crystals.	Hydrogen	17-25	WNK lysine deficient protein kinase 1	Homo sapiens	111-114
30820880-0	2019	Assessing the Metabolomic Profile of Multiple Sclerosis Patients Treated with Interferon Beta 1a by 1H-NMR Spectroscopy.	Hydrogen	100-102	interferon beta 1	Homo sapiens	78-95
31785324-5	2020	Despite the robust H2A/H2B dimer-displacement effect of mNAP1 with the H2BK34ub (but not unmodified) nucleosomes, NAP1 could assemble symmetrically- or asymmetrically ubiquitylated nucleosomes under "physiological" conditions in vitro.	Hydrogen	23-26	nucleosome assembly protein 1-like 1	Mus musculus	56-61
31785324-5	2020	Despite the robust H2A/H2B dimer-displacement effect of mNAP1 with the H2BK34ub (but not unmodified) nucleosomes, NAP1 could assemble symmetrically- or asymmetrically ubiquitylated nucleosomes under "physiological" conditions in vitro.	Hydrogen	23-26	nucleosome assembly protein 1-like 1	Mus musculus	57-61
30645027-0	2019	Unique 1D Cd1- x Znx S@O-MoS2 /NiOx Nanohybrids: Highly Efficient Visible-Light-Driven Photocatalytic Hydrogen Evolution via Integrated Structural Regulation.	Hydrogen	102-110	CD1c molecule	Homo sapiens	10-13
32035750-4	2020	Molecular docking studies indicated that 12Aj appeared to form stable hydrogen bonds with either Aurora A or Aurora B.	Hydrogen	70-78	aurora kinase A	Homo sapiens	97-105
30972932-8	2019	This synthesis strategy reported for FePS3 porous nanosheets paves a new pathway for designing other dianion-based inorganic nanocrystals for hydrogen energy applications.	Hydrogen	142-150	sodium voltage-gated channel alpha subunit 11	Homo sapiens	37-42
30857263-8	2019	The obtained results showed that this binding is thermodynamically favorable and beta-glucuronidase inhibition of the selected compounds increases with the number of hydrogen bonding established in selected compound-beta-glucuronidase complexes.	Hydrogen	166-174	glucuronidase beta	Homo sapiens	81-99
30857263-8	2019	The obtained results showed that this binding is thermodynamically favorable and beta-glucuronidase inhibition of the selected compounds increases with the number of hydrogen bonding established in selected compound-beta-glucuronidase complexes.	Hydrogen	166-174	glucuronidase beta	Homo sapiens	216-234
31911176-4	2020	The FTIR test showed the forming of new hydrogen bonds between the CS hydroxyl groups and nanoparticles.	Hydrogen	40-48	citrate synthase	Homo sapiens	67-69
30758936-8	2019	These beneficial factors make the optimized C60-decorated SnS2/CuInS2 photocathode exhibit much higher photocathodic current (4.51 mA cm-2 at applied potential -0.45 V vs reversible hydrogen electrode ) and stability than the individual CuInS2 (2.58 mA cm-2) and SnS2 (1.92 mA cm-2) nanosheet film photocathodes.	Hydrogen	182-190	sodium voltage-gated channel alpha subunit 11	Homo sapiens	58-62
31223650-3	2019	Here, we show that, under a geoelectrochemical condition realizable in the early ocean hydrothermal systems, several metal sulfides (FeS, Ag2S, CuS, and PbS) undergo hour- to day-scale conversion to the corresponding metals at &lt;=-0.7 V (versus the standard hydrogen electrode).	Hydrogen	260-268	angiotensin II receptor type 1	Homo sapiens	138-142
32017556-4	2020	In this study, a H2/alpha-keto acid EFC was developed for the conversion from chemically inert nitrogen gas to chiral amino acids, powered by H2 oxidation.	Hydrogen	17-19	H2A clustered histone 18	Homo sapiens	15-16
31197487-1	2019	Quantum chemical computations were applied to investigate the characteristics of open-shell hydrogen-bonding interactions in the complexes of carbamic acid (NH2COOH, CA) with HO2, HOS and HSO radicals.	Hydrogen	92-100	heme oxygenase 2	Homo sapiens	175-178
30842554-7	2019	The observed interaction energies and hydrogen bonds in dsRNA-bound TLR3 wild-type and mutant complexes indicate the presence of a weak dimer interface at the TLR3 ECD C-terminal site, which is required for effective dsRNA binding.	Hydrogen	38-46	toll like receptor 3	Homo sapiens	68-72
30842554-7	2019	The observed interaction energies and hydrogen bonds in dsRNA-bound TLR3 wild-type and mutant complexes indicate the presence of a weak dimer interface at the TLR3 ECD C-terminal site, which is required for effective dsRNA binding.	Hydrogen	38-46	toll like receptor 3	Homo sapiens	159-163
32085471-2	2020	Following suitable organic chemistry transformation, the -OH end groups were converted to moieties able to form complementary hydrogen bonds including 2,6-diaminopurine, Dap, thymine, Thy, and the so-called Hamilton receptor, Ham.	Hydrogen	126-134	death associated protein	Homo sapiens	170-173
30612031-5	2019	The maximum SMA of acetate and hydrogen was 0.61 and 0.45 g COD-CH4/g VSS/d, respectively under 0.8 atm HPP.	Hydrogen	31-39	survival of motor neuron 1, telomeric	Homo sapiens	12-15
32085471-3	2020	The formation of hydrogen bonds was examined between the polymers PS-Dap and PS-b-PI-Thy, along with the polymers PS-Ham and PS-b-PI-Thy.	Hydrogen	17-25	death associated protein	Homo sapiens	69-72
32104537-6	2020	Furthermore, H2 inhalation reduced the expression of Bcl-2-associated X protein (BAX) and caspase-3 while promoting the expression of Bcl-2, nuclear factor erythroid-2-related factor 2, and heme oxygenase-1 (HO-1).	Hydrogen	13-15	caspase 3	Rattus norvegicus	90-99
30801087-3	2019	The total amount of hydrogen evolution and the turnover number (TON) of catalysis using this AP system were 385.7 mumol and 3857 (per Rh ion), respectively; these values are higher than those of [Rh(dtBubpy)3](PF6)3, which is the most efficient HEC among the mononuclear rhodium complexes, and RhCl3.	Hydrogen	20-28	sperm associated antigen 17	Homo sapiens	210-213
31917549-3	2020	Viperin orients the C4" hydrogen atom of CTP and UTP similarly for abstraction by a 5"-deoxyadenosyl radical, but the uracil moiety introduces unfavorable interactions that prevent tight binding of UTP.	Hydrogen	24-32	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7
31406663-0	2019	Stimulated Electrocatalytic Hydrogen Evolution Activity of MOF-Derived MoS2 Basal Domains via Charge Injection through Surface Functionalization and Heteroatom Doping.	Hydrogen	28-36	lysine acetyltransferase 8	Homo sapiens	59-62
31406663-4	2019	The zinc-nitrogen coordinated cobalt-molybdenum disulfide shows exceptional catalytic activity and stability toward the hydrogen evolution reaction with a low overpotential of 72.6 mV at -10 mA cm-2 and a small Tafel slope of 37.6 mV dec-1.	Hydrogen	120-128	deleted in esophageal cancer 1	Homo sapiens	234-239
30591552-3	2019	Molecular simulations showed that Ser-6 in Pep8 forms a hydrogen bond with Asp-202 in eIF4E.	Hydrogen	56-64	eukaryotic translation initiation factor 4E	Homo sapiens	86-91
30615440-4	2019	Here, we utilize vibrational sum frequency generation spectroscopy (vSFG) to characterize the orientation and hydrogen-bonding environment of near-surface hydroxyls inside mica.	Hydrogen	110-118	MHC class I polypeptide-related sequence A	Homo sapiens	172-176
30523058-4	2019	Structural studies of Sirt5 in complex with four succinyl peptides indicate an essential role for the conserved main chain hydrogen bonds formed by the succinyl lysine (0), +1, and +3 sites for substrate-enzyme recognition.	Hydrogen	123-131	sirtuin 5	Homo sapiens	22-27
32029879-7	2020	Hydrogen abrogated ovalbumin sensitization and challenge-induced upregulation of glycolytic enzymes and hypoxia-inducible factor-1alpha, and downregulation of mitochondrial respiratory chain complexes and peroxisome proliferator activated receptor-gamma coactivator-1alpha.	Hydrogen	0-8	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	205-272
31633226-10	2020	The binding free energy of the spinosine (-15.30 kcal/mol) is relatively higher than the venenatine (-11.8 kcal/mol); this increment is attributed to the strong hydrogen bonding interactions of spinosine molecule with the active site amino acid residues of p300.	Hydrogen	161-169	E1A binding protein p300	Homo sapiens	257-261
30788005-0	2019	Postconditioning with inhaled hydrogen attenuates skin ischemia/reperfusion injury through the RIP-MLKL-PGAM5/Drp1 necrotic pathway.	Hydrogen	30-38	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Rattus norvegicus	104-109
31838617-5	2020	While the applied different concentrations (1%, 10%, 50% and 100%) of hydrogen-rich water (HRW) conducted different affects in alleviating the senescence of cut roses, and 1% HRW displayed the best ornamental quality and the longest vase life by reducing ethylene production, supported by the decrease of 1-aminocyclopropene-1-carboxylate (ACC) accumulation, ACC synthase (ACS) and ACC oxidase (ACO) activities, and Rh-ACS3 and Rh-ACO1 expressions in ethylene biosynthesis.	Hydrogen	70-78	aconitase 1	Homo sapiens	431-435
30446621-9	2019	Further analysis of the CAIV-binding site revealed that the His-88 in CAIV can either act as H donor or H acceptor for the hydrogen bond, depending on the charge of the binding residue in the chaperone.	Hydrogen	123-131	carbonic anhydrase 4	Homo sapiens	24-28
30446621-9	2019	Further analysis of the CAIV-binding site revealed that the His-88 in CAIV can either act as H donor or H acceptor for the hydrogen bond, depending on the charge of the binding residue in the chaperone.	Hydrogen	123-131	carbonic anhydrase 4	Homo sapiens	70-74
31816684-3	2020	The sensor utilizes polystyrene-based 2D PC colloidal arrays (2D PCCA) hydrogel with methacrylic acid as the functional monomer which can imprint the L-KYN template by hydrogen bonding.	Hydrogen	168-176	propionyl-CoA carboxylase subunit alpha	Homo sapiens	65-69
30539957-2	2019	The reduction proceeded smoothly with a chiral diamine ruthenium complex as a catalyst and a HCOOH-NEt3 azeotrope as both a hydrogen source and solvent under mild conditions.	Hydrogen	124-132	tetraspanin 2	Homo sapiens	99-103
32038231-13	2019	Molecular docking assay showed that the oxygen atom on the five-membered ring of ATLIII was capable of forming a hydrogen bond with Leu905-NH2 site of Jak3 protein.	Hydrogen	113-121	Janus kinase 3	Mus musculus	151-155
30798936-11	2019	From the simulation studies, we observed higher deviation, lower protein compactness, and a decrease in the number of intramolecular hydrogen bonds in the mutant W764C MSH2-MSH6 protein complex.	Hydrogen	133-141	mutS homolog 2	Homo sapiens	168-172
30145443-1	2019	Polyacrylonitrile polymeric (PAN/CoAc) and metal oxide (Co3O4/Nfs) nanofibrous structured composite catalysts for the hydrogen production are successfully fabricated by simple, low cost, high yield, and effective technique: electrospinning.	Hydrogen	118-126	phosphopantothenoylcysteine decarboxylase	Homo sapiens	33-37
31924176-0	2020	Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.	Hydrogen	0-8	caspase 1	Mus musculus	60-69
30560918-3	2018	Here we report, using hydrogen/deuterium exchange, mechanistic models for dysregulated RIG-I proofreading that ultimately result in the improper recognition of cellular RNAs bearing 7-methylguanosine and N1-2"-O-methylation (Cap1) on the 5" end.	Hydrogen	22-30	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	225-229
31924176-9	2020	Hydrogen pretreatment upregulated ROS and the expression of pyroptosis-related proteins, and increased the number of PI- and TUNEL-positive cells, as well as the release of LDH and IL-1beta, however, GSDMD depletion reduced their release.	Hydrogen	0-8	gasdermin D	Homo sapiens	200-205
31789019-2	2020	Here, synergistic effect of electrochemiluminescence (ECL) is observed unprecedentedly in a new cyclometalated dinuclear Ir(III) complex [Ir2(dfppy)4(imiphenH)]PF6 (1 PF6, PF6- = hexafluorophosphate) in which two {Ir(dfppy)2}+ units are bridged by an imiphenH- ligand.	Hydrogen	150-158	sperm associated antigen 17	Homo sapiens	160-163
30775234-6	2019	As a result, hollow FeP/C nanosheets exhibit excellent electrocatalytic performance for the hydrogen evolution reaction in 0.5 m H2SO4 with a quite low overpotential of 51.1 mV at 10 mA cm-2, small Tafel slope of 41.7 mV dec-1, and remarkable long-term stability.	Hydrogen	92-100	deleted in esophageal cancer 1	Homo sapiens	221-226
31458326-5	2018	To exploit this idea, here, in the present work, we have synthesized semiconducting Ag2S nanoparticles and successfully doped them with different transition metals like Mn, Fe, Co, and Ni to study their electrocatalytic activity for the hydrogen evolution reaction from neutral water (pH = 7).	Hydrogen	237-245	angiotensin II receptor type 1	Homo sapiens	84-88
29994198-6	2018	In this paper, bent dipole antennas tuned to 1H were integrated with a four channel 31P loop coil array, in a manner providing strong geometric decoupling between dipoles and loops.	Hydrogen	45-47	coilin	Homo sapiens	93-97
30176257-5	2018	The results of DSC, TLC, 1H NMR spectroscopy, and 2D ROESY showed that the Sit-HP-beta-CD inclusion complex was successfully synthesized.	Hydrogen	25-27	beta-carotene oxygenase 1	Mus musculus	82-89
30513583-0	2018	Corrosion of Hydrogen Storage Metal Alloy LaMm-Ni4.1Al0.3Mn0.4Co0.45 in the Aqueous Solutions of Alkali Metal Hydroxides.	Hydrogen	13-21	laminin subunit alpha 2	Homo sapiens	42-46
29986579-8	2018	Detailed analyses of hIAPP-SWCNT-OH interactions reveal that hydrogen bonding, van der Waals, and pi-stacking interactions between hIAPP and SWCNT-OH significantly weaken the inter- and intrapeptide interactions that are crucial for beta-sheet formation.	Hydrogen	61-69	islet amyloid polypeptide	Homo sapiens	21-26
29986579-8	2018	Detailed analyses of hIAPP-SWCNT-OH interactions reveal that hydrogen bonding, van der Waals, and pi-stacking interactions between hIAPP and SWCNT-OH significantly weaken the inter- and intrapeptide interactions that are crucial for beta-sheet formation.	Hydrogen	61-69	islet amyloid polypeptide	Homo sapiens	131-136
30338972-4	2018	Specifically, as a hydrogen evolution reaction catalyst, the optimal Ir/g-C3N4/NG exhibits a Tafel slope of 22 mV dec-1.	Hydrogen	19-27	deleted in esophageal cancer 1	Homo sapiens	114-119
30254073-0	2018	Dimerization interface of osteoprotegerin revealed by hydrogen-deuterium exchange mass spectrometry.	Hydrogen	54-62	TNF receptor superfamily member 11b	Homo sapiens	26-41
30254073-3	2018	Employing hydrogen-deuterium exchange MS methods, here we investigated the structure of full-length OPG in complex with HS or RANKL in solution.	Hydrogen	10-18	TNF receptor superfamily member 11b	Homo sapiens	100-103
30368623-4	2018	The MD analyses focus on the location of the ligands with respect to the experimental binding site and on the direct and water-mediated hydrogen bonds (H bonds) they form with CD58.	Hydrogen	136-144	CD58 molecule	Homo sapiens	176-180
30500804-7	2018	In addition, composites with Ag2S loading of 1% possessed the highest hydrogen production ability of photolysis water, indicating that the introduction of Ag2S had significantly enhanced the catalytic performance.	Hydrogen	70-78	angiotensin II receptor type 1	Homo sapiens	29-33
30500804-7	2018	In addition, composites with Ag2S loading of 1% possessed the highest hydrogen production ability of photolysis water, indicating that the introduction of Ag2S had significantly enhanced the catalytic performance.	Hydrogen	70-78	angiotensin II receptor type 1	Homo sapiens	155-159
30212210-12	2018	The rearrangement of AT1R is then propagated to the intracellular side of the receptor through the conformational change of residue Trp253 (the toggle switch), which results in an expansion of the pocket for G protein binding and the breakage of the hydrogen bond containing the conserved residue Arg126.	Hydrogen	250-258	angiotensin II receptor type 1	Homo sapiens	21-25
30145050-5	2018	Furthermore, we determined the crystal structures of JAK1, JAK2, JAK3, and TYK2 in a complex with peficitinib, and revealed that the 1H-pyrrolo[2,3-b]pyridine-5-carboxamide scaffold of peficitinib forms triple hydrogen bonds with the hinge region.	Hydrogen	210-218	tyrosine kinase 2	Homo sapiens	75-79
30015176-7	2018	The molecular docking studies showed that amines group have good binding interaction on active site residues of TP such as compounds 2j and 2o exhibited hydrogen bond interaction with amino acid residues GLY152, THR151 and HIS116 of thymidine phosphorylase (PDB ID: 1UOU).	Hydrogen	153-161	thymidine phosphorylase	Homo sapiens	112-114
30015176-7	2018	The molecular docking studies showed that amines group have good binding interaction on active site residues of TP such as compounds 2j and 2o exhibited hydrogen bond interaction with amino acid residues GLY152, THR151 and HIS116 of thymidine phosphorylase (PDB ID: 1UOU).	Hydrogen	153-161	thymidine phosphorylase	Homo sapiens	233-256
30310274-0	2018	1H-NMR-based metabolic profiling of healthy individuals and high-resolution CT-classified phenotypes of COPD with treatment of tiotropium bromide.	Hydrogen	0-2	COPD	Homo sapiens	104-108
30310274-7	2018	The method of metabolomics based on 1H nuclear magnetic resonance (1H-NMR) was used to compare the changes in serum metabolites between COPD patients and normal controls and between different phenotypes of COPD patients in pre- and post-therapy.	Hydrogen	67-69	COPD	Homo sapiens	136-140
30310274-13	2018	Conclusion: The efficacy of tiotropium bromide on COPD phenotype E is better than that of phenotype M. Metabolites detected by 1H-NMR metabolomics have potentialities of differentiation of COPD and healthy people, discrimination of different COPD phenotypes, and giving insight into the individualized treatment of COPD.	Hydrogen	127-129	COPD	Homo sapiens	50-54
30310274-13	2018	Conclusion: The efficacy of tiotropium bromide on COPD phenotype E is better than that of phenotype M. Metabolites detected by 1H-NMR metabolomics have potentialities of differentiation of COPD and healthy people, discrimination of different COPD phenotypes, and giving insight into the individualized treatment of COPD.	Hydrogen	127-129	COPD	Homo sapiens	189-193
30310274-13	2018	Conclusion: The efficacy of tiotropium bromide on COPD phenotype E is better than that of phenotype M. Metabolites detected by 1H-NMR metabolomics have potentialities of differentiation of COPD and healthy people, discrimination of different COPD phenotypes, and giving insight into the individualized treatment of COPD.	Hydrogen	127-129	COPD	Homo sapiens	189-193
30310274-13	2018	Conclusion: The efficacy of tiotropium bromide on COPD phenotype E is better than that of phenotype M. Metabolites detected by 1H-NMR metabolomics have potentialities of differentiation of COPD and healthy people, discrimination of different COPD phenotypes, and giving insight into the individualized treatment of COPD.	Hydrogen	127-129	COPD	Homo sapiens	189-193
31950689-0	2018	In Situ Decoration of Znx Cd1-x S with FeP for Efficient Photocatalytic Generation of Hydrogen under Irradiation with Visible Light.	Hydrogen	86-94	CD1c molecule	Homo sapiens	26-29
29614516-8	2018	According to the docked pose and MD simulation, compound 13 was expected to interact with the S1" specificity loop of MMP-2 and had 2 pi-pi interactions and a stable hydrogen bond with the MMP-2 active site.	Hydrogen	166-174	matrix metallopeptidase 2	Homo sapiens	189-194
29782975-6	2018	While, when this interaction was repaired whether by forming hydrogen bond or salt bond, it would cause JAK2 activation.	Hydrogen	61-69	Janus kinase 2	Homo sapiens	104-108
29921037-6	2018	Meanwhile, H2 inhibited the overexpression of MCP-1, E-selectin, P-selectin and ICAM-1 in oxidant-induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines (TNF-alpha, IL-1, IL-6 and IL-8) production in the wound.	Hydrogen	11-13	intercellular adhesion molecule 1	Mus musculus	80-86
29921037-6	2018	Meanwhile, H2 inhibited the overexpression of MCP-1, E-selectin, P-selectin and ICAM-1 in oxidant-induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines (TNF-alpha, IL-1, IL-6 and IL-8) production in the wound.	Hydrogen	11-13	interleukin 1 complex	Mus musculus	203-207
29921037-6	2018	Meanwhile, H2 inhibited the overexpression of MCP-1, E-selectin, P-selectin and ICAM-1 in oxidant-induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines (TNF-alpha, IL-1, IL-6 and IL-8) production in the wound.	Hydrogen	11-13	chemokine (C-X-C motif) ligand 15	Mus musculus	218-222
29921037-7	2018	Furthermore, H2 promoted the expression of pro-healing factors (IL-22, TGF-beta, VEGF and IGF1) and inhibited the production of MMP9 in wound tissue in parallel with acceleration of cutaneous collagen synthesis.	Hydrogen	13-15	insulin-like growth factor 1	Mus musculus	90-94
29921037-7	2018	Furthermore, H2 promoted the expression of pro-healing factors (IL-22, TGF-beta, VEGF and IGF1) and inhibited the production of MMP9 in wound tissue in parallel with acceleration of cutaneous collagen synthesis.	Hydrogen	13-15	matrix metallopeptidase 9	Mus musculus	128-132
31391979-2	2019	There are two N-H O hydrogen bonds in the structure: one hydrogen bond links mol-ecules related by a 41 screw axis to form a C(6) chain, and the other links inversion-related pairs of mol-ecules to form an R 2 2(8) ring.	Hydrogen	20-28	complement C6	Homo sapiens	125-129
31391979-2	2019	There are two N-H O hydrogen bonds in the structure: one hydrogen bond links mol-ecules related by a 41 screw axis to form a C(6) chain, and the other links inversion-related pairs of mol-ecules to form an R 2 2(8) ring.	Hydrogen	57-65	complement C6	Homo sapiens	125-129
31002240-4	2019	Optoelectronic measurements reveal that the MOF-modified electrode is catalytically active to hydrogen evolution under light irradiation in neutral solution.	Hydrogen	94-102	lysine acetyltransferase 8	Homo sapiens	44-47
30873691-4	2019	The Pd1 /N-graphene catalyst exhibits outstanding activity and selectivity for the hydrogenation of C2 H2 with H2 in the presence of excess C2 H4 under photothermal heating (UV and visible-light irradiation from a Xe lamp), achieving 99% conversion of acetylene and 93.5% selectivity to ethylene at 125  C. This remarkable catalytic performance is attributed to the high concentration of Pd active sites on the catalyst surface and the weak adsorption energy of ethylene on isolated Pd atoms, which prevents C2 H4 hydrogenation.	Hydrogen	103-105	programmed cell death 1	Homo sapiens	4-7
30632402-6	2019	RESULTS: N-methyl quaternization of CS was confirmed by 1H NMR.	Hydrogen	56-58	citrate synthase	Homo sapiens	36-38
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Hydrogen	44-46	Janus kinase 2	Homo sapiens	27-31
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Hydrogen	44-46	mutS homolog 2	Homo sapiens	84-88
29687635-4	2018	The binding modes of the compounds obtained using Glide docking have exhibited up to 2 hinge-region hydrogen bonds to CDK2 and differed in the orientation of the inhibitor core and the placement of the 8-substituents.	Hydrogen	100-108	cyclin dependent kinase 2	Homo sapiens	118-122
29389052-1	2018	Easy-to-prepare eta2 -coordinated phosphine-borane ligands are demonstrated to liberate hydrogen upon treatment with different sigma-donor/pi-acceptor ligands (CO, tBuNC, CN- ).	Hydrogen	88-96	DNA polymerase iota	Homo sapiens	16-20
31789019-2	2020	Here, synergistic effect of electrochemiluminescence (ECL) is observed unprecedentedly in a new cyclometalated dinuclear Ir(III) complex [Ir2(dfppy)4(imiphenH)]PF6 (1 PF6, PF6- = hexafluorophosphate) in which two {Ir(dfppy)2}+ units are bridged by an imiphenH- ligand.	Hydrogen	150-158	sperm associated antigen 17	Homo sapiens	167-170
29852353-13	2018	All data suggested that H2 inhibited lung cancer progression through down-regulating SMC3, a regulator for chromosome condensation, which provided a new method for the treatment of lung cancer.	Hydrogen	24-26	structural maintenance of chromosomes 3	Homo sapiens	85-89
31789019-2	2020	Here, synergistic effect of electrochemiluminescence (ECL) is observed unprecedentedly in a new cyclometalated dinuclear Ir(III) complex [Ir2(dfppy)4(imiphenH)]PF6 (1 PF6, PF6- = hexafluorophosphate) in which two {Ir(dfppy)2}+ units are bridged by an imiphenH- ligand.	Hydrogen	150-158	sperm associated antigen 17	Homo sapiens	167-170
31947886-7	2020	The H6 in CETP (beta = 0.52, p = 0.015; odds ratio (OR) = 1.87, p = 0.009) and H5 in LIPC (beta = 0.56, p &lt; 0.001; OR = 1.51, p = 0.002) have a significant increasing effect on TG/HDL-C ratio and have shown higher prevalence among the Roma, as compared to Hungarian general population.	Hydrogen	79-81	lipase C, hepatic type	Homo sapiens	85-89
29673582-8	2018	In silico analysis of this region showed that it is in contact with several residues of the E1beta subunit mainly through polar contacts, hydrogen bonds, and hydrophobic interactions.	Hydrogen	138-146	branched chain keto acid dehydrogenase E1 subunit beta	Homo sapiens	92-106
30735837-8	2019	We also found that hydrogen decreased the expression of the DNA damage-related protein ATM, cyclinD1 and NF-kappaB but increased the expression of the DNA repair-related protein HMGB1, suggesting that hydrogen inhibits senescence in retinas of NaIO3 mice.	Hydrogen	19-27	ataxia telangiectasia mutated	Mus musculus	87-90
30735837-8	2019	We also found that hydrogen decreased the expression of the DNA damage-related protein ATM, cyclinD1 and NF-kappaB but increased the expression of the DNA repair-related protein HMGB1, suggesting that hydrogen inhibits senescence in retinas of NaIO3 mice.	Hydrogen	19-27	high mobility group box 1	Mus musculus	178-183
30735837-8	2019	We also found that hydrogen decreased the expression of the DNA damage-related protein ATM, cyclinD1 and NF-kappaB but increased the expression of the DNA repair-related protein HMGB1, suggesting that hydrogen inhibits senescence in retinas of NaIO3 mice.	Hydrogen	201-209	ataxia telangiectasia mutated	Mus musculus	87-90
30735837-8	2019	We also found that hydrogen decreased the expression of the DNA damage-related protein ATM, cyclinD1 and NF-kappaB but increased the expression of the DNA repair-related protein HMGB1, suggesting that hydrogen inhibits senescence in retinas of NaIO3 mice.	Hydrogen	201-209	high mobility group box 1	Mus musculus	178-183
31704785-3	2020	Here, we showed that mice (both females and males) with a heterozygous mutation in the first coding exon of Hnrnph1 (H1+/-) showed reduced methamphetamine reinforcement and intake and dose-dependent changes in methamphetamine reward as measured via conditioned place preference.	Hydrogen	117-119	heterogeneous nuclear ribonucleoprotein H1	Mus musculus	108-115
30558837-2	2019	The aim of the study was to investigate the biochemical profile of SMA in PSP patients, using proton magnetic resonance spectroscopy (1H-MRS).	Hydrogen	134-136	survival of motor neuron 1, telomeric	Homo sapiens	67-70
29791776-5	2018	Structural analysis of rod-like apoC-II fibrils, using hydrogen-deuterium exchange and NMR analysis showed exchange protection consistent with a core cross-beta structure comprising the C-terminal 58-76 region.	Hydrogen	55-63	apolipoprotein C2	Homo sapiens	32-39
29947280-7	2018	Furthermore, binding mode analysis revealed that all the compounds bound to the ATP site and most of the hydrogen bonding interactions are conserved as in GSK3beta structures deposited in PDB.	Hydrogen	105-113	glycogen synthase kinase 3 beta	Homo sapiens	155-163
31704785-6	2020	Surprisingly, there was a two-fold increase in hnRNP H protein in the striatal synaptosome of H1+/- mice with no change in whole tissue levels.	Hydrogen	94-97	heterogeneous nuclear ribonucleoprotein H1	Mus musculus	47-54
31036024-10	2019	CONCLUSIONS: This study indicates that the combination of BMP-2/HA within Mg screws enhances new bone formation and therefore has the potential to decrease the complications of hydrogen gas formation around these implants.	Hydrogen	177-185	bone morphogenetic protein 2	Oryctolagus cuniculus	58-63
31896753-6	2020	The electrocatalytic activity of the nanograin film is comprehensively examined by micro-electrochemical measurements, showing an excellent hydrogen-evolution performance (onset potential: -25 mV and Tafel slope: 54 mV dec-1), thus indicating an intrinsically high activation of the TMD GBs.	Hydrogen	140-148	deleted in esophageal cancer 1	Homo sapiens	219-224
30882832-7	2019	These data suggest an attractor ordering of H- &gt; CO &gt; H2 &gt; PR3 &gt; Cl- ~ CH3CN.	Hydrogen	60-62	proteinase 3	Homo sapiens	68-71
30960753-0	2018	Improved Hydrogen Separation Using Hybrid Membrane Composed of Nanodiamonds and P84 Copolyimide.	Hydrogen	9-17	THO complex 1	Homo sapiens	80-83
31818479-12	2020	Docking simulations discovers hydrogen bonding and hydrophobic interactions as responsible for the binding affinities of hits to the CYP17A1 Protein Data Bank structure.	Hydrogen	30-38	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	133-140
29989628-2	2018	The 1H NMR and crystal structure measurements indicate that both 1 PF6 and 2 PF6 contain intramolecular pipi stacking interactions between the non-coordinated N-methylbenzoimidazole/benzimidazole unit and the tpy ligand, but there are no such pipi interactions in 3 PF6.	Hydrogen	4-6	sperm associated antigen 17	Homo sapiens	67-70
29989628-2	2018	The 1H NMR and crystal structure measurements indicate that both 1 PF6 and 2 PF6 contain intramolecular pipi stacking interactions between the non-coordinated N-methylbenzoimidazole/benzimidazole unit and the tpy ligand, but there are no such pipi interactions in 3 PF6.	Hydrogen	4-6	sperm associated antigen 17	Homo sapiens	77-80
29989628-2	2018	The 1H NMR and crystal structure measurements indicate that both 1 PF6 and 2 PF6 contain intramolecular pipi stacking interactions between the non-coordinated N-methylbenzoimidazole/benzimidazole unit and the tpy ligand, but there are no such pipi interactions in 3 PF6.	Hydrogen	4-6	sperm associated antigen 17	Homo sapiens	77-80
29754833-6	2018	In the course of modification, renin inhibitory activity was enhanced by the formation of an additional hydrogen bonding with the hydroxyl group of Thr77.	Hydrogen	104-112	renin	Rattus norvegicus	31-36
30997425-0	2019	Modelling and evaluation of PEM hydrogen technologies for frequency ancillary services in future multi-energy sustainable power systems.	Hydrogen	32-40	mucin 1, cell surface associated	Homo sapiens	28-31
30997425-3	2019	Next, the technical characteristics of PEM hydrogen technologies and their potential uses within the electrical power system are discussed to evaluate their adequacy to the requirements of ancillary services markets.	Hydrogen	43-51	mucin 1, cell surface associated	Homo sapiens	39-42
30997425-7	2019	The obtained results show that PEM hydrogen technologies can improve the frequency response when compared to the procurement with synchronous generators of the same reserve value.	Hydrogen	35-43	mucin 1, cell surface associated	Homo sapiens	31-34
31746080-7	2020	In addition, by mutating potential amino acid residues of ATP1A3, which were predicted by modelling and docking to interact with CS-6, we demonstrated that abrogating hydrogen bonding of the amino acid Thr794 interferes with the activation of ATP1A3 by CS-6 and that the Thr794Ala mutation directly affects the synergistic treatment efficacy of CS-6 and TMZ.	Hydrogen	167-175	ATPase Na+/K+ transporting subunit alpha 3	Homo sapiens	58-64
30827111-4	2019	In particular, a strong suppression of HER (below 5% Faradaic efficiency (FE) at -0.8 V vs the reversible hydrogen electrode, RHE) during 20 h was observed.	Hydrogen	106-114	factor interacting with PAPOLA and CPSF1	Homo sapiens	126-129
30018557-10	2018	Proton acceptors constituting the structure of these compounds and hydrogen bonds with AMPK in the binding site appeared to be the important factors determining the efficacy of these compounds.	Hydrogen	67-75	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	87-91
31746080-7	2020	In addition, by mutating potential amino acid residues of ATP1A3, which were predicted by modelling and docking to interact with CS-6, we demonstrated that abrogating hydrogen bonding of the amino acid Thr794 interferes with the activation of ATP1A3 by CS-6 and that the Thr794Ala mutation directly affects the synergistic treatment efficacy of CS-6 and TMZ.	Hydrogen	167-175	ATPase Na+/K+ transporting subunit alpha 3	Homo sapiens	243-249
31746080-8	2020	CONCLUSIONS: As the main potential target of CS-6, ATP1A3 activation critically depends on the hydrogen bonding of Thr794 with CS-6.	Hydrogen	95-103	ATPase Na+/K+ transporting subunit alpha 3	Homo sapiens	51-57
30265352-8	2018	Computational modeling indicates that removal of a Gly from CDR2 does not perturb contact with RTA per se, but results in the loss of an intramolecular hydrogen bond network involved in stabilizing CDR2 in the unbound state.	Hydrogen	152-160	cerebellar degeneration related protein 2	Homo sapiens	60-64
30265352-8	2018	Computational modeling indicates that removal of a Gly from CDR2 does not perturb contact with RTA per se, but results in the loss of an intramolecular hydrogen bond network involved in stabilizing CDR2 in the unbound state.	Hydrogen	152-160	cerebellar degeneration related protein 2	Homo sapiens	198-202
31526998-8	2020	Furthermore, hydrogen bonds between As(III) and PSMPs were broken at high temperatures, resulting in a decrease in As(III) adsorption onto PSMP, which indicated that the adsorption process was exothermic.	Hydrogen	13-21	microseminoprotein, prostate associated	Homo sapiens	48-52
30536727-3	2019	Statistically significant correlation was observed when docking experiments in the extra precision mode carried out by applying core constraints in the ligand molecule which forms two specific hydrogen bonds with Val 96 of CDK4.	Hydrogen	193-201	cyclin dependent kinase 4	Homo sapiens	223-227
30536727-5	2019	The presence of a water molecule which forms a hydrogen bond with Asp158 increased the binding affinity between the ligand and CDK4.	Hydrogen	47-55	cyclin dependent kinase 4	Homo sapiens	127-131
31284868-9	2020	The binding free energies predicted are in good agreement with the experimental bioactivities and the free energy calculations showed that the binding of GSK3beta/inhibitors was mainly contributed from hydrogen bonding and hydrophobic interaction.	Hydrogen	202-210	glycogen synthase kinase 3 alpha	Homo sapiens	154-162
30660872-0	2019	Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.	Hydrogen	0-8	high mobility group box 1	Mus musculus	21-26
30660872-8	2019	RESULTS: The results indicated that 2% H2 gas treatment increased the survival rates, decreased the W/D weight ratio and the lung injury score, alleviated the injuries caused by oxidative stress and inflammation, and induced HO-1 level but reduced HMGB1 level in WT but not Krf2-KO mice.	Hydrogen	39-41	high mobility group box 1	Mus musculus	248-253
30660872-9	2019	These data reveal that H2 gas could suppress lung injury in septic mice through regulation of HO-1 and HMGB1 expression and that Nrf2 plays a main role in the protective effects of H2 gas on lung damage caused by sepsis.	Hydrogen	23-25	high mobility group box 1	Mus musculus	103-108
29847724-2	2018	By minimizing the number of hydrogen bond donors while targeting a previously uncovered selectivity pocket adjacent to the ATP binding site of PI3Kgamma, we discovered a series of azaisoindolinones as selective, brain penetrant inhibitors of PI3Kgamma.	Hydrogen	28-36	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	242-251
29546905-0	2018	A chiral aluminum solvating agent (CASA) for 1H NMR chiral analysis of alcohols at low temperature.	Hydrogen	45-47	casein alpha s1	Homo sapiens	35-39
32003675-9	2020	RESULTS: The results reveal that Doxorubicin, Neratinib maleate, Epirubicin and Lapatinib Ditosylate has good hydrogen bonding interaction with GPR116 receptor protein binding site.	Hydrogen	110-118	adhesion G protein-coupled receptor F5	Homo sapiens	144-150
29546905-1	2018	A chiral aluminum solvating agent (CASA) was demonstrated to be a general and efficient reagent for 1H NMR chiral analysis of alcohols.	Hydrogen	100-102	casein alpha s1	Homo sapiens	35-39
29946338-10	2018	1H NMR spectroscopy was employed to determine the Lac/Cr ratio.	Hydrogen	0-2	lactase	Homo sapiens	50-53
30708245-8	2019	In addition, the possible mechanism showing high photo-catalytic activity of hydrogen evolution for CoP and WP is proposed by a series of other characterizations, such as SEM, TEM, XPS, BET, transient photo-current response, steady-state fluorescence, transient-state fluorescence and Mott-Schottky studies etc.	Hydrogen	77-85	delta/notch like EGF repeat containing	Homo sapiens	186-189
30888362-5	2019	For the optimized Cu3P 0.75Co2P catalyst, a low overpotential of 124.6 mV@-20 mA cm-2 is required with a Tafel slope of 65 mV dec-1 for the hydrogen evolution reaction (HER) and an overpotential of 334 mV (at 20 mA cm-2) is required for the oxygen evolution reaction (OER).	Hydrogen	140-148	deleted in esophageal cancer 1	Homo sapiens	126-131
31937177-0	2020	Saturated hydrogen alleviates CCl4-induced acute kidney injury via JAK2/STAT3/p65 signaling.	Hydrogen	10-18	Janus kinase 2	Homo sapiens	67-71
30655288-6	2019	Unlike the canonical PIP box of p68, the PIP box of p12 lacks the conserved glutamine; binds through a 2-fork plug made of an isoleucine and a tyrosine residue at +3 and +8 positions, respectively; and is stabilized by an aspartate at +6 position, which creates a network of intramolecular hydrogen bonds.	Hydrogen	290-298	DNA polymerase delta 4, accessory subunit	Homo sapiens	52-55
30828707-0	2019	Comparison of hydrogen vacancies in KDP and ADP crystals: a combination of density functional theory calculations and experiment.	Hydrogen	14-22	WNK lysine deficient protein kinase 1	Homo sapiens	36-39
30828707-1	2019	The hydrogen vacancy (VH) is the most common point defect that may lead to optical damage of potassium dihydrogen phosphate (KDP) and its analog ammonium dihydrogen phosphate (ADP), further limiting their practical application in high-power laser systems.	Hydrogen	4-12	WNK lysine deficient protein kinase 1	Homo sapiens	125-128
29133131-5	2018	SRS spectra of 2M NaOH water solution with ice-VII and ice-VIII structures have been successfully obtained in forward and backward, respectively, as OH- greatly reduce the quantum nature of hydrogen bonds by neutralizing H+ in water.	Hydrogen	190-198	cytochrome c oxidase subunit 8A	Homo sapiens	59-63
29575754-3	2018	Most potent MIF tautomerase inhibitors incorporate a phenol, which hydrogen bonds to Asn97 in the active site.	Hydrogen	67-75	macrophage migration inhibitory factor	Homo sapiens	12-15
31937177-0	2020	Saturated hydrogen alleviates CCl4-induced acute kidney injury via JAK2/STAT3/p65 signaling.	Hydrogen	10-18	RELA proto-oncogene, NF-kB subunit	Homo sapiens	78-81
29575754-5	2018	Crystal structures of complexes of MIF with the pyrazoles highlight the contributions of hydrogen bonding with Lys32 and Asn97, and aryl-aryl interactions with Tyr36, Tyr95, and Phe113 to the binding.	Hydrogen	89-97	macrophage migration inhibitory factor	Homo sapiens	35-38
31513206-3	2019	Complex 2a immediately reacted with the liberated dihydrogen to yield mu-eta2-dihydrobipyridine (dhbpy) complex 4a via C-C bond formation between the two pyridyl groups, in which one of the pyridine rings underwent partial hydrogenation.	Hydrogen	50-60	DNA polymerase iota	Homo sapiens	73-77
29408005-1	2018	The effect of mucin hydrogen bonding on the structure of intestinal mucus has been studied with micro-differential scanning mirocalorimetry (mu-DSC), supported by spectroscopy.	Hydrogen	20-28	LOC100508689	Homo sapiens	14-19
29408005-6	2018	The above are complemented by UV spectroscopy: A blue shift of the conjugated aminoacids in the presence of DMSO suggests that the inherent stability of mucin is not only due to steric volume exclusions, but also due to extensive hydrogen bonding on behalf of the sugar moieties.	Hydrogen	230-238	LOC100508689	Homo sapiens	153-158
30069319-13	2018	Results: H2 ameliorated CS-induced lung function decline, emphysema, inflammatory cell infiltration, small-airway remodelling, goblet-cell hyperplasia in tracheal epithelium and activated ERK1/2 and NF-kappaB in mouse lung.	Hydrogen	9-11	mitogen-activated protein kinase 3	Mus musculus	188-194
30069319-16	2018	Conclusions: These findings demonstrated that H2 inhalation could inhibit CS-induced COPD development in mice, which is associated with reduced ERK1/2 and NF-kappaB-dependent inflammatory responses.	Hydrogen	46-48	mitogen-activated protein kinase 3	Mus musculus	144-150
30593826-0	2019	Hydrogen bond analysis of the EGFR-ErbB3 heterodimer related to non-small cell lung cancer and drug resistance.	Hydrogen	0-8	erb-b2 receptor tyrosine kinase 3	Homo sapiens	35-40
31513206-5	2019	Complex 4a was reversibly converted to 5a via the elimination of dihydrogen in which the dhbpy moiety adopts a mu-eta2:eta2 mode.	Hydrogen	65-75	DNA polymerase iota	Homo sapiens	114-118
29847807-0	2018	Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange.	Hydrogen	77-85	immunoglobulin kappa variable 1-5	Homo sapiens	34-37
31513206-5	2019	Complex 4a was reversibly converted to 5a via the elimination of dihydrogen in which the dhbpy moiety adopts a mu-eta2:eta2 mode.	Hydrogen	65-75	DNA polymerase iota	Homo sapiens	119-123
30354009-7	2019	Our results elucidate the importance of three hydrogen bond acceptors (A), one hydrogen bond donor (D), one hydrophobic group (H), and one positive ionic charge (P) toward inhibition of the Ak2.	Hydrogen	46-54	adenylate kinase 2	Homo sapiens	190-193
31871445-4	2019	We analysed the result of the hydrogen breath test with lactose loading, two single nucleotide polymorphisms of the LCT gene (LCT-13910CC and LCT-22018GG).	Hydrogen	30-38	lactase	Homo sapiens	116-119
30354009-7	2019	Our results elucidate the importance of three hydrogen bond acceptors (A), one hydrogen bond donor (D), one hydrophobic group (H), and one positive ionic charge (P) toward inhibition of the Ak2.	Hydrogen	79-87	adenylate kinase 2	Homo sapiens	190-193
29466765-3	2018	Previous investigations described association between a genetic superoxide-hydrogen (S-HP) imbalance caused by a superoxide dismutase manganese dependent gene polymorphism (Val16Ala-SOD2 SNP, rs4880) and differential anti-inflammatory response of some drugs and bioactive molecules.	Hydrogen	75-83	superoxide dismutase 2	Homo sapiens	182-186
31575642-2	2019	2H is incorporated into fatty acids via exchange between body water and the hydrogens of acetyl-CoA, malonyl-CoA, and NADPH.	Hydrogen	76-85	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	118-123
29548571-4	2018	Differential hydrogen-deuterium exchange experiments were used to help understand the structural basis for binding to ERRgamma and aid in the development of more potent ligands.	Hydrogen	13-21	estrogen related receptor gamma	Homo sapiens	118-126
29548571-4	2018	Differential hydrogen-deuterium exchange experiments were used to help understand the structural basis for binding to ERRgamma and aid in the development of more potent ligands.	Hydrogen	13-21	activation induced cytidine deaminase	Homo sapiens	131-134
29339227-9	2018	The in-situ deprotonation of the ligand on both Mg2+ and Zn2+ ions binding was confirmed by 1H NMR titration studies.	Hydrogen	92-94	mucin 7, secreted	Homo sapiens	48-51
29511086-4	2018	In this work we measured the local dynamics of the IF state of P-gp in lipid nanodiscs and in detergent solution by hydrogen-deuterium (H/D) exchange MS. We observed "EX1 exchange kinetics," or bimodal kinetics, for several peptides distributed in both NBDs, particularly for P-gp in the lipid nanodiscs.	Hydrogen	116-124	FERM domain containing 6	Homo sapiens	167-170
29595949-9	2018	The binding of UMP to OMPDC results in an unusually large &gt;12 unit decrease in the p Ka = 29 for abstraction of the C-6 substrate hydrogen, due to stabilization of an enzyme-bound vinyl carbanion, which is also an intermediate of OMPDC-catalyzed decarboxylation.	Hydrogen	133-141	complement C6	Homo sapiens	119-122
29643478-0	2018	Mucin gel assembly is controlled by a collective action of non-mucin proteins, disulfide bridges, Ca2+-mediated links, and hydrogen bonding.	Hydrogen	123-131	LOC100508689	Homo sapiens	0-5
29090418-5	2018	Here we report the 1H, 13C and 15N backbone and side-chain chemical shift assignments of frataxin from Chaetomium thermophilum, a thermophile increasingly used by virtue of its stability.	Hydrogen	19-21	frataxin	Homo sapiens	89-97
29448111-8	2018	DKC1 showed significant hydrogen bonding as well as remarkable binding affinity values of -17.4 kcal/mol with miR-720 (2 H-bonds), -16 kcal/mol with miR-1246 (1 H-bond) and -16.9 kcal/mol with miR-1308 (3 H-bonds).	Hydrogen	24-32	dyskerin pseudouridine synthase 1	Homo sapiens	0-4
29301981-5	2018	We found that targeted deuteration efficiently redirected the preferable cleavage site and suppressed reaction rate by APAO and SMOX in vitro We found a three- to six-fold decline in Vmax with moderate variable effect on Km when deuterium was located at the preferred hydrogen abstraction site of the analogue.	Hydrogen	268-276	spermine oxidase	Homo sapiens	128-132
29350035-1	2018	Ion current densities near 1 A cm-2 at modest bias voltages (&lt;200 mV) are reported for proton and deuteron transmission across single-layer graphene in polyelectrolyte-membrane (PEM)-style hydrogen pump cells.	Hydrogen	192-200	mucin 1, cell surface associated	Homo sapiens	155-179
29350035-1	2018	Ion current densities near 1 A cm-2 at modest bias voltages (&lt;200 mV) are reported for proton and deuteron transmission across single-layer graphene in polyelectrolyte-membrane (PEM)-style hydrogen pump cells.	Hydrogen	192-200	mucin 1, cell surface associated	Homo sapiens	181-184
29240969-2	2018	4 reacts with H2 to give [Ru(IPr)2 (CO)(eta2 -H2 )(InMe)(H)][BArF4 ], 5, while CO induces formation of the indyl complex [Ru(IPr)2 (CO)3 (InMe2 )][BArF4 ], 7.	Hydrogen	14-16	DNA polymerase iota	Homo sapiens	40-44
31938167-9	2018	This present study demonstrates that comparatively conservative intraspecific genetic variations of E. multilocularis exist in Xinjiang Uyghur Autonomous Region and the main epidemic haplotypes in Xinjiang are H1 (cox1) and H1 (cytb).	Hydrogen	224-226	CYTB	Echinococcus multilocularis	228-232
30686295-1	2018	An optimal H2 minimization framework is proposed in this paper for devising a controller of PID in nature, based on a refined IMC filter configuration.	Hydrogen	11-13	metastasis associated 1 family member 2	Homo sapiens	92-95
29198892-6	2018	Plasma IDUA levels for all treated groups were high at 1h after injection and decreased by 95% at 4h, indicating efficient distribution into tissues.	Hydrogen	55-57	iduronidase, alpha-L	Mus musculus	7-11
29379131-7	2018	Molecular modeling studies exhibited additional hydrogen bond interaction between 1i and the residue Lys37 of p65, indicating that 1i could form covalent protein adducts with Cys38 on p65.	Hydrogen	48-56	RELA proto-oncogene, NF-kB subunit	Homo sapiens	110-113
29379131-7	2018	Molecular modeling studies exhibited additional hydrogen bond interaction between 1i and the residue Lys37 of p65, indicating that 1i could form covalent protein adducts with Cys38 on p65.	Hydrogen	48-56	RELA proto-oncogene, NF-kB subunit	Homo sapiens	184-187
29024174-0	2018	Li2 NH-LiBH4 : a Complex Hydride with Near Ambient Hydrogen Adsorption and Fast Lithium Ion Conduction.	Hydrogen	51-59	ATP binding cassette subfamily A member 12	Homo sapiens	0-3
29024174-3	2018	The Li2 NH-LiBH4 sample (in a molar ratio of 1:1) shows excellent hydrogenation kinetics, starting to absorb H2 at 310 K, which is more than 100 K lower than that of pristine Li2 NH.	Hydrogen	109-111	ATP binding cassette subfamily A member 12	Homo sapiens	4-7
29024174-3	2018	The Li2 NH-LiBH4 sample (in a molar ratio of 1:1) shows excellent hydrogenation kinetics, starting to absorb H2 at 310 K, which is more than 100 K lower than that of pristine Li2 NH.	Hydrogen	109-111	ATP binding cassette subfamily A member 12	Homo sapiens	175-178
29024174-4	2018	Furthermore, the Li+ ion conductivity of the Li2 NH-LiBH4 sample is about 1.0x10-5  S cm-1 at room temperature, and is higher than that of either Li2 NH or LiBH4 at 373 K. Those unique properties of the Li2 NH-LiBH4 complex render it a promising candidate for hydrogen storage and Li ion conduction.	Hydrogen	260-268	ATP binding cassette subfamily A member 12	Homo sapiens	45-48
29382075-3	2018	Compound 1h is the most potent URAT1 inhibitor discovered in our laboratories so far and also comparable to the most potent ones currently under development in clinical trials.	Hydrogen	9-11	solute carrier family 22 member 12	Homo sapiens	31-36
29348627-7	2018	In silico analysis showed close (&lt;=1.7 A) polar interaction (hydrogen bond) between Glu4, Arg7, 96, 225 of nsP2 with Lys256, 206, Val367 and Phe312 of nsP1 respectively.	Hydrogen	64-72	reticulon 2	Homo sapiens	110-114
28873532-3	2018	Electrostatic-interactions and hydrogen-bonding contributed to the intermolecular aggregation in the myosin-SA system and enhanced its intermolecular interactions by overcoming the steric hindrance effect of SA with heavier molecules.	Hydrogen	31-39	myosin, heavy chain 15	Gallus gallus	101-107
29763919-15	2018	The expression levels of Cox8b, Cox6a2, Cox7a1, Hspb7, and Atp2a1 were inhibited by hydrogen treatment.	Hydrogen	84-92	cytochrome c oxidase subunit 8B	Mus musculus	25-30
29763919-19	2018	Cox8b, Cox6a2, Cox7a1, Hspb7, and Atp2a1 were identified as potential target genes of hydrogen treatment.	Hydrogen	86-94	cytochrome c oxidase subunit 8B	Mus musculus	0-5
30445348-10	2019	Furthermore, the synthetic catalyst shows the low-value overpotential of 108 mV and Tafel slope of 48 mV dec-1 during the hydrogen evolution process in acidic media.	Hydrogen	122-130	deleted in esophageal cancer 1	Homo sapiens	105-110
30594033-6	2019	Adiabatic mapping calculations indicated that H110 and R48 residues play essential catalyst roles for CS enzyme catalysis by transition state (TS) and product stabilizations via charge polarization and hydrogen bonding to EPSP and/or FMNH2.	Hydrogen	202-210	citrate synthase	Homo sapiens	102-104
30714593-7	2019	We find C60(OH)24 binds to hIAPP via hydrogen bonding interactions with polar residues T9, Q10, N14, N21, N22, N31, N35 and T36 as well as the collective van der Waals and hydrogen-bonding interaction with Y37.	Hydrogen	37-45	islet amyloid polypeptide	Homo sapiens	27-32
30714593-7	2019	We find C60(OH)24 binds to hIAPP via hydrogen bonding interactions with polar residues T9, Q10, N14, N21, N22, N31, N35 and T36 as well as the collective van der Waals and hydrogen-bonding interaction with Y37.	Hydrogen	172-180	islet amyloid polypeptide	Homo sapiens	27-32
30960263-0	2019	Hydrogen Storage, Magnetism and Electrochromism of Silver Doped FAU Zeolite: First-Principles Calculations and Molecular Simulations.	Hydrogen	0-8	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	64-67
30960263-4	2019	The H2 adsorption capacities and binding energies represent significant dependence on the content, location, and electronic property of Ag cations introduced into the FAU zeolites.	Hydrogen	4-6	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	167-170
30136377-13	2019	CONCLUSION: Exercise training restores bleomycin-induced downregulation of pulmonary CBS/CSE expression, thus contributing to the increased H2 S generation and suppression of TGF-beta1/Smad and LRP-6/beta-catenin signalling pathways, EMT and lung fibrosis.	Hydrogen	140-142	cystathionase (cystathionine gamma-lyase)	Mus musculus	89-92
30353291-2	2019	In-electrospray ionization (ESI) hydrogen/deuterium exchange-mass spectrometry (HDX-MS) is a promising technique for studying carbohydrate conformations since rapidly exchanging functional groups, e.g., hydroxyls, can be labeled on the timeframe of ESI.	Hydrogen	33-41	highly divergent homeobox	Homo sapiens	80-83
29310523-8	2019	Hydrogen bond occupancy of NS7 and NS9 generated from MD trajectories showed good interaction with the flap residues Gln73, Thr72 of BACE-1 and Arg141, Thr138 residues of GSK-3beta.	Hydrogen	0-8	glycogen synthase kinase 3 beta	Homo sapiens	171-180
31250600-1	2019	OBJECTIVE: To investigate the hypothesis that hydrogen could ameliorate cecal ligation and puncture (CLP)-induced lung injury of rats by inhibiting cystathionine-gamma-lyase/hydrogen sulfide (CSE/H2S) system.	Hydrogen	46-54	cystathionine gamma-lyase	Rattus norvegicus	148-173
30106070-9	2019	A plecstatin analogue that substituted a hydrogen bond acceptor with a hydrogen bond donor abrogated the target selectivity for plectin in HCT116 whole cell lysates, underlining the necessity of this hydrogen bond acceptor for a strong interaction between plecstatin and plectin.	Hydrogen	41-49	plectin	Homo sapiens	128-135
30106070-9	2019	A plecstatin analogue that substituted a hydrogen bond acceptor with a hydrogen bond donor abrogated the target selectivity for plectin in HCT116 whole cell lysates, underlining the necessity of this hydrogen bond acceptor for a strong interaction between plecstatin and plectin.	Hydrogen	71-79	plectin	Homo sapiens	128-135
30106070-9	2019	A plecstatin analogue that substituted a hydrogen bond acceptor with a hydrogen bond donor abrogated the target selectivity for plectin in HCT116 whole cell lysates, underlining the necessity of this hydrogen bond acceptor for a strong interaction between plecstatin and plectin.	Hydrogen	71-79	plectin	Homo sapiens	128-135
30479216-7	2019	RESULTS: Results indicated a strong affinity of antifolate inhibitors for the conserved active site of PPAT molecule encompassing a number of hydrophobic, hydrogen bonding, Vander Waals and electrostatic interactions.	Hydrogen	155-163	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	103-107
30907314-9	2019	The expression levels of p- JAK2/JAK2, p-STAT3/STAT3 were upregulated in the hydrogen-rich water group compared with the control group, and p-STAT1/STAT1 was downregulated in the hydrogen-rich water group compared with the control group.	Hydrogen	77-85	signal transducer and activator of transcription 1	Rattus norvegicus	142-147
30907314-9	2019	The expression levels of p- JAK2/JAK2, p-STAT3/STAT3 were upregulated in the hydrogen-rich water group compared with the control group, and p-STAT1/STAT1 was downregulated in the hydrogen-rich water group compared with the control group.	Hydrogen	77-85	signal transducer and activator of transcription 1	Rattus norvegicus	148-153
31274955-0	2019	Thermally Stable Cross-linked P84 with Superior Membrane H2/CO2 Separation Properties at 100  C. Polymers with a strong size-sieving ability and superior H2/CO2 selectivity are of great interests for pre-combustion CO capture at 100  C or above.	Hydrogen	57-59	THO complex 1	Homo sapiens	30-33
31274955-0	2019	Thermally Stable Cross-linked P84 with Superior Membrane H2/CO2 Separation Properties at 100  C. Polymers with a strong size-sieving ability and superior H2/CO2 selectivity are of great interests for pre-combustion CO capture at 100  C or above.	Hydrogen	154-156	THO complex 1	Homo sapiens	30-33
31274955-4	2019	An exemplary sample based on P84 crosslinked by BuDA for 6 h exhibits a H2 permeability of 47 Barrers (1 Barrer = 3.35 x 10-16 mol m/m2 s Pa) and H2/CO2 selectivity of 14 at 100  C, which is on the Robeson"s upper bound, indicating their potential for practical applications.	Hydrogen	72-74	THO complex 1	Homo sapiens	29-32
30588060-7	2018	Citrin is aspartate/glutamate transporter in mitochondria, a component of malate-aspartate nicotinamide adenine dinucleotide hydrogen shuttle, and is essential for the hepatic glycolysis.	Hydrogen	125-133	solute carrier family 25 member 13	Homo sapiens	0-6
30518154-6	2018	Molecular docking studies indicate that capsaicin exhibits the highest binding efficacy to TRPV1 because it has a hydrogen bond that anchors it to TRPV1.	Hydrogen	114-122	transient receptor potential cation channel subfamily V member 1	Homo sapiens	91-96
30518154-6	2018	Molecular docking studies indicate that capsaicin exhibits the highest binding efficacy to TRPV1 because it has a hydrogen bond that anchors it to TRPV1.	Hydrogen	114-122	transient receptor potential cation channel subfamily V member 1	Homo sapiens	147-152
30041222-7	2018	Also, results of immunostaining analysis revealed increased vimentin and apoptotic cells in the membrane of the PD group, indicating that H2 may play a role in ameliorating PDS-induced peritoneal injury and preserving peritoneal integrity.	Hydrogen	138-140	vimentin	Rattus norvegicus	60-68
28390099-8	2018	Diabetic nephropathy analysis showed significant reductions in urine volume, urinary total protein and beta2-microglobulin, kidney/bodyweight ratio, and kidney fibrosis associated with subcutaneous injection of H2 .	Hydrogen	211-213	beta-2 microglobulin	Mus musculus	103-122
31575642-7	2019	Transfer of glucose 2H into fatty acid position 3 was more extensive (0.46 +- 0.04 relative to 13C, P < 10-5 vs. position 2), indicating a more limited exchange of those glucose hydrogens that were transferred via NADPH.	Hydrogen	178-187	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	214-219
29459541-0	2018	[Measurement Accuracy of Fat and Iron Deposits in the Liver Using 1H-MRS (HISTO)].	Hydrogen	66-68	FAT atypical cadherin 1	Homo sapiens	25-28
31850366-5	2019	DNA in nucleosomes lacking a histone H2A/H2B dimer was drastically deformed due to loss of local interactions between DNA and histones.	Hydrogen	41-44	H2A clustered histone 18	Homo sapiens	37-40
29459541-1	2018	1H-MRS, which is a method of measuring fat and iron deposits in the liver, has a single voxel spectroscopy imaging method called high-speed T2-corrected multiecho (HISTO) based on the STEAM method.	Hydrogen	0-2	FAT atypical cadherin 1	Homo sapiens	39-42
31850366-6	2019	In contrast, conformation of DNA in nucleosomes lacking H3/H4 was similar to the canonical nucleosome, as the H2A C-terminal domain infiltrated the space originally occupied by the dissociated H3/H4 histones and restricted DNA dynamics in close proximity.	Hydrogen	196-198	H2A clustered histone 18	Homo sapiens	110-113
28642078-0	2018	Experimental tests on commercial Sweet Product Residue (SPR) as a suitable feed for anaerobic bioenergy (H2+CH4) production.	Hydrogen	105-108	sepiapterin reductase	Homo sapiens	56-59
31850366-7	2019	Our results suggest that, besides histone chaperones, the intrinsic dynamics of nucleosomes support the exchange of H2A/H2B, which is significantly more frequent than that of H3/H4.	Hydrogen	120-123	H2A clustered histone 18	Homo sapiens	116-119
31850366-7	2019	Our results suggest that, besides histone chaperones, the intrinsic dynamics of nucleosomes support the exchange of H2A/H2B, which is significantly more frequent than that of H3/H4.	Hydrogen	178-180	H2A clustered histone 18	Homo sapiens	116-119
32647818-10	2020	The potent character of CB-1158 is presumably due to its increased rigidity compared to ABH as well as the formation of an additional hydrogen-bond network as observed by resolution of the Arginase-1/CB-1158 crystal structure.	Hydrogen	134-142	arginase 1	Homo sapiens	189-199
29199739-0	2017	A Cu(ii)-MOF capable of fixing CO2 from air and showing high capacity H2 and CO2 adsorption.	Hydrogen	70-72	lysine acetyltransferase 8	Homo sapiens	9-12
29199739-1	2017	A porous Cu(ii)-MOF shows an adsorption of 6.6 wt% of H2 at 77 K and 62 bar and a very high 60 wt% of CO2 at 298 K and 32 bar.	Hydrogen	54-56	lysine acetyltransferase 8	Homo sapiens	16-19
29284910-6	2017	Asn41 made more interactions with glucokinase than the other residues in the peptide, including hydrogen bonds and salt-bridge These bioactive peptides appear to help glucokinase to bind glucose, since the number of hydrogen bonds between the protein and the glucose was higher and their distances shorter in the complex with the peptides without disturbing the glucose position for phosphorylation.	Hydrogen	216-224	glucokinase	Capra hircus	167-178
31005352-0	2019	Corrigendum to "FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia" [Behav.	Hydrogen	99-107	forkhead box O1	Rattus norvegicus	16-21
32499664-1	2017	Described herein is a comprehensive project-a large-scale test of an integrated refrigeration and storage system called the Ground Operations and Demonstration Unit for Liquid Hydrogen (GODU LH2), sponsored by the Advanced Exploration Systems Program and constructed at Kennedy Space Center.	Hydrogen	176-184	LIM homeobox 2	Homo sapiens	191-194
31476557-3	2019	Various residues capable of forming hydrogen bonds as well as salt bridges were placed in this pocket via a carboxamides linkage, which led to drastic improvement of potency and selectivity towards hCA IV.	Hydrogen	36-44	carbonic anhydrase 4	Homo sapiens	198-204
28235359-1	2017	Dimorfolido-N-trichloroacetylphosphorylamide (HL1) and dimorfolido-N-benzoylphosphorylamide (HL2) as representatives of carbacylamidophosphates were synthesized and identified by the methods of IR, 1H, and 31P NMR spectroscopy.	Hydrogen	198-200	intelectin 2	Homo sapiens	93-96
27931177-14	2017	In silico analysis revealed that vitexin binds effectively with AChE through strong hydrogen bonding.	Hydrogen	84-92	acetylcholinesterase	Mus musculus	64-68
31400653-4	2019	HRT 2 d resulted in (1) maximum removal efficiencies for COD, carbohydrate, lipid and protein contents with values of 58.5, 58.4, 62.6 and 79.1%, respectively; (2) peak hydrogen and methane production rates of 714 and 254 mL/L-d, respectively; and (3) biogas contents of hydrogen 8.6% and methane 48.0% in the produced gas.	Hydrogen	169-177	hes related family bHLH transcription factor with YRPW motif 2	Homo sapiens	0-5
29225478-6	2017	In this article, we look at approaches used to identify biomarkers of HCC using proton nuclear magnetic resonance (1H-NMR) spectroscopy of urine samples.	Hydrogen	115-117	HCC	Homo sapiens	70-73
29250399-8	2017	In both salt and co-crystal, the water mol-ecule links the chloranilic acid and 2-carb-oxy-pyridine mol-ecules through O-H O and N-H O hydrogen bonds.	Hydrogen	135-143	syntaxin 8	Homo sapiens	82-86
29250399-9	2017	The 2-carb-oxy-pyridine mol-ecules are connected into a head-to-head inversion dimer by a short O-H O hydrogen bond, in which the H atom is disordered over two positions.	Hydrogen	102-110	syntaxin 8	Homo sapiens	6-10
29250399-11	2017	The water mol-ecule links the chloranilic acid and 2-carb-oxy-quinoline mol-ecules through O-H O hydrogen bonds.	Hydrogen	97-105	syntaxin 8	Homo sapiens	53-57
31400653-4	2019	HRT 2 d resulted in (1) maximum removal efficiencies for COD, carbohydrate, lipid and protein contents with values of 58.5, 58.4, 62.6 and 79.1%, respectively; (2) peak hydrogen and methane production rates of 714 and 254 mL/L-d, respectively; and (3) biogas contents of hydrogen 8.6% and methane 48.0% in the produced gas.	Hydrogen	271-279	hes related family bHLH transcription factor with YRPW motif 2	Homo sapiens	0-5
29250399-12	2017	The 2-carb-oxy-quinoline mol-ecules are connected into a head-to-tail inversion dimer by a pair of N-H O hydrogen bonds.	Hydrogen	105-113	syntaxin 8	Homo sapiens	6-10
30982748-0	2019	Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.	Hydrogen	0-8	FAT atypical cadherin 1	Homo sapiens	34-37
29250212-8	2017	The MBP-cholesterol interaction suggests a significant concentrations and surface pressure dependence and is probably governed by hydrogen bonds.	Hydrogen	130-138	myelin basic protein	Homo sapiens	4-7
30189949-3	2018	After electrochemical treatment, the obtained N-NPCs-ET with Pt as counter electrode exhibited an unexpected high hydrogen evolution activity, which had low onset overpotential of 100 mV and a Tafel slope of 60 mV dec-1.	Hydrogen	114-122	deleted in esophageal cancer 1	Homo sapiens	214-219
30982748-3	2019	The aim of this study was to analyze the effects of 28-day hydrogen-rich water intake on liver fat deposition, body composition and lab chemistry profiles in overweight patients suffering from mild-to-moderate NAFLD.	Hydrogen	59-67	FAT atypical cadherin 1	Homo sapiens	95-98
30982748-8	2019	Baseline liver fat content was reduced from 284.0 +- 118.1 mM to 256.5 +- 108.3 mM after hydrogen treatment at 28-day follow-up (percent change 2.9%; 95% CI from 0.5 to 5.5).	Hydrogen	89-97	FAT atypical cadherin 1	Homo sapiens	15-18
29035047-9	2017	Importantly, for these two oxidation events, the calculated potential values of Ep,a = 1.01 and 1.59 V vs normal hydrogen electrode (NHE) agree well with the experimental values of Ep,a = 0.93 and 1.51 V vs NHE in pH 10 carbonate buffer.	Hydrogen	113-121	solute carrier family 9 member C1	Homo sapiens	133-136
31401268-9	2019	The presence of a "blind zone" in the 1H NMR spectrum obviously indicated the binding of Cr(III) to GLP.	Hydrogen	38-40	euchromatic histone methyltransferase 1	Mus musculus	100-103
29035047-9	2017	Importantly, for these two oxidation events, the calculated potential values of Ep,a = 1.01 and 1.59 V vs normal hydrogen electrode (NHE) agree well with the experimental values of Ep,a = 0.93 and 1.51 V vs NHE in pH 10 carbonate buffer.	Hydrogen	113-121	solute carrier family 9 member C1	Homo sapiens	207-210
28869216-5	2017	Furthermore, the Ni9S8/O-MoS2 nanocomposite also shows highly electrocatalytic features for hydrogen production with an onset overpotential of ~150 mV and a low Tafel slope of ~81 mV dec-1.	Hydrogen	92-100	deleted in esophageal cancer 1	Homo sapiens	183-188
30746074-3	2019	Herein we present the first example of reversible HSe- binding in two distinct synthetic supramolecular receptors, using hydrogen bonds from N-H and aromatic C-H moieties.	Hydrogen	121-129	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	50-53
30350837-3	2018	GQDs initiated contact with IAPP through electrostatic and hydrophobic interactions as well as hydrogen bonding, which subsequently drove the peptide fibrillization off-pathway to eliminate the toxic intermediates.	Hydrogen	95-103	islet amyloid polypeptide	Homo sapiens	28-32
31398569-8	2019	The significant enhancement is ascribed to CQDs @ Pd promoting the charge carrier separation on SnS2 and increasing the adsorption of active hydrogen from the hydrolysis of NaBH4.	Hydrogen	141-149	sodium voltage-gated channel alpha subunit 11	Homo sapiens	96-100
29201197-14	2017	In the HS+CGRP group, apoptotic cells and caspase-3 protein in the brain were significantly decreased when compared with those in the HS group (P&lt;0.05), while they were significantly increased in the HS+CGRP8-37 group (P&lt;0.05 vs. HS group).	Hydrogen	7-9	calcitonin-related polypeptide alpha	Rattus norvegicus	10-14
29201197-14	2017	In the HS+CGRP group, apoptotic cells and caspase-3 protein in the brain were significantly decreased when compared with those in the HS group (P&lt;0.05), while they were significantly increased in the HS+CGRP8-37 group (P&lt;0.05 vs. HS group).	Hydrogen	7-9	caspase 3	Rattus norvegicus	42-51
30334032-1	2018	The double excited state intramolecular proton transfer (ESIPT) of 3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazole (bis-HPTA), a molecule possessing two intramolecular hydrogen bonded donor-acceptor pairs, has been investigated.	Hydrogen	163-171	hepatocyte growth factor	Homo sapiens	115-119
29772390-2	2019	CS is due to loss-of-function mutations in SLC9A6, encoding NHE6, a sodium-hydrogen exchanger involved in the regulation of early endosomal pH.	Hydrogen	75-83	solute carrier family 9 (sodium/hydrogen exchanger), member 6	Mus musculus	43-49
30205977-11	2018	Based on these findings, we propose that during local yield events, OC and OPN rely on ionic interactions of their charged side chains and on hydrogen bonding to dissipate energy in bone.	Hydrogen	142-150	secreted phosphoprotein 1	Mus musculus	75-78
29044144-2	2017	The stability of this novel gem-diol compound is found owning to the hydrogen bonds with lattice water molecules and electrophilic tetrazolyl groups.	Hydrogen	69-77	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	28-31
29038582-0	2017	Direct visualization of critical hydrogen atoms in a pyridoxal 5"-phosphate enzyme.	Hydrogen	33-41	pyridoxal phosphatase	Homo sapiens	53-75
29772390-2	2019	CS is due to loss-of-function mutations in SLC9A6, encoding NHE6, a sodium-hydrogen exchanger involved in the regulation of early endosomal pH.	Hydrogen	75-83	solute carrier family 9 (sodium/hydrogen exchanger), member 6	Mus musculus	60-64
31450226-12	2019	In silico study revealed that curcumolide bound with ATP-binding sites of the VEGFR2 kinase unit by the formation of a hydrogen bond and hydrophobic interactions.	Hydrogen	119-127	kinase insert domain protein receptor	Mus musculus	78-84
28807355-0	2017	Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.	Hydrogen	0-8	regucalcin	Mus musculus	81-86
28807355-9	2017	Administration of H2-rich water attenuated the CS-induced lung damage in the SMP30-KO mice and reduced the mean linear intercept and destructive index of the lungs.	Hydrogen	18-20	regucalcin	Mus musculus	77-82
30269486-1	2018	Hydrogen-rich DNA dinucleotide cation radicals (dGG + 2H)+ , (dCG + 2H)+ , and (dGC + 2H)+  represent transient species comprising protonated and hydrogen atom adducted nucleobase rings that serve as models for proton and radical migrations in ionized DNA.	Hydrogen	0-8	gamma-glutamyl carboxylase	Drosophila melanogaster	80-83
30269486-1	2018	Hydrogen-rich DNA dinucleotide cation radicals (dGG + 2H)+ , (dCG + 2H)+ , and (dGC + 2H)+  represent transient species comprising protonated and hydrogen atom adducted nucleobase rings that serve as models for proton and radical migrations in ionized DNA.	Hydrogen	146-154	gamma-glutamyl carboxylase	Drosophila melanogaster	80-83
30207028-3	2018	During the hydrogen evolution reaction (HER) catalysis, the optimized porous Mo3 P/Mo nanobelts exhibited a small overpotential of 78 mV at a current density of 10 mA cm-2 and a low Tafel slope of 43 mV dec-1 , as well as long-term stability in alkaline media, surpassing Pt wire.	Hydrogen	11-19	deleted in esophageal cancer 1	Homo sapiens	203-208
31454650-9	2019	EFL1 interacted with proteins via hydrogen bonding.	Hydrogen	34-42	elongation factor like GTPase 1	Homo sapiens	0-4
28919439-3	2017	We characterized the structure of the ScR2TP complex made up of two AAA+ ATPases, Rvb1/2p, and two Hsp90 binding proteins, Tah1p and Pih1p, and its interaction with the snoRNP protein Nop58p by a combination of analytical ultracentrifugation, isothermal titration calorimetry, chemical crosslinking, hydrogen-deuterium exchange, and cryoelectron microscopy methods.	Hydrogen	300-308	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	38-42
30486721-13	2019	In silico docking showed that hydrogen bonds and hydrophobic interactions contributed to the inhibition of Schisandrin B on CES1, Anwuligan on CES2, and Schisandrin B on CES2.	Hydrogen	30-38	carboxylesterase 1	Homo sapiens	124-128
28930439-0	2017	Controlled Synthesis of MOF-Encapsulated NiPt Nanoparticles toward Efficient and Complete Hydrogen Evolution from Hydrazine Borane and Hydrazine.	Hydrogen	90-98	lysine acetyltransferase 8	Homo sapiens	24-27
28930439-3	2017	The resultant Ni0.9Pt0.1/MOF core-shell composite with a low Pt content exerted exceedingly high activity and durability for complete H2 evolution (100% hydrogen selectivity) from alkaline N2H4BH3 and N2H4 H2O solution.	Hydrogen	134-136	lysine acetyltransferase 8	Homo sapiens	25-28
31655912-0	2019	Chemisorption-repulsion energies of H2 on surface (110) of Mg1-xMx alloys (M = Al, Ni, Zn; 0.0 &lt;= x &lt;= 0.20) as a function of temperature.	Hydrogen	36-38	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	59-62
28930439-3	2017	The resultant Ni0.9Pt0.1/MOF core-shell composite with a low Pt content exerted exceedingly high activity and durability for complete H2 evolution (100% hydrogen selectivity) from alkaline N2H4BH3 and N2H4 H2O solution.	Hydrogen	153-161	lysine acetyltransferase 8	Homo sapiens	25-28
28549396-8	2017	After noise exposure, the concentrations of IL-1, IL-6, TNF-alpha, and ICAM-1 in the cochlea of guinea pigs in the hydrogen-saturated saline group were dramatically reduced compared to those in the normal saline group.	Hydrogen	115-123	tumor necrosis factor	Cavia porcellus	56-65
28549396-9	2017	The concentrations of HMGB-1 and IL-10 in the hydrogen-saturated saline group were significantly higher than in those in the normal saline group immediately and at 7 d after noise exposure.	Hydrogen	46-54	high mobility group protein B1	Cavia porcellus	22-28
30144244-1	2018	A biomimetic (titin protein molecular structure) strategy is reported for preparing transparent and healable elastomers featuring supertoughness (345 MJ m-3 ) and high tensile strength (44 MPa) after self-healing enabled by hierarchical (single, double, and quadruple) hydrogen-bonding moieties in the polymer backbone.	Hydrogen	269-277	titin	Homo sapiens	14-19
31566359-3	2019	Impressively, the optimized hybrid exhibits an outstanding hydrogen evolution reaction (HER) activity with the quite small Tafel slope of 19.77 mV dec-1 and ultralow overpotential of just 25 mV to reach a current density of 10 mA cm-2 in alkaline media.	Hydrogen	59-67	deleted in esophageal cancer 1	Homo sapiens	147-152
30284974-22	2018	In the structures of compounds (I), (VI), (VII) and (VIII), hydrogen bonds generate simple chains, while a chain of rings is formed in (V).	Hydrogen	60-68	cytochrome c oxidase subunit 8A	Homo sapiens	53-57
28271277-5	2017	Here we report the 1H, 13C and 15N backbone resonance assignments of human EDN (RNase 2) and its molecular dynamics simulation on the microsecond timescale, providing means to pursue this comparative atomic-scale functional and dynamical analysis by NMR and computation over multiple time frames.	Hydrogen	19-21	ribonuclease A family member 2	Homo sapiens	75-78
28271277-5	2017	Here we report the 1H, 13C and 15N backbone resonance assignments of human EDN (RNase 2) and its molecular dynamics simulation on the microsecond timescale, providing means to pursue this comparative atomic-scale functional and dynamical analysis by NMR and computation over multiple time frames.	Hydrogen	19-21	ribonuclease A family member 2	Homo sapiens	80-87
29842959-5	2018	When F556 was replaced by other amino acids except Trp, the hydrogen bond, JH2 domain"s structural conformation and JH1-JH2 domains" interactions disrupted for changing the helix between beta2 and beta3 strands which finally caused JAK2 activation.	Hydrogen	60-68	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	197-202
31352109-8	2019	Based on these findings and the characterization of supernatants from HGF migration assays on Mg membranes, we propose, that the slower migration rate of HGF can be explained by the altered ratio of Mg2+ to Ca2+, caused by increasing concentrations of Mg2+ and decreasing concentrations of Ca2+ in the vicinity of the corroding Mg implant, combined with a constantly increased molecular hydrogen concentration in the supernatant.	Hydrogen	387-395	hepatocyte growth factor	Homo sapiens	154-157
29987523-9	2018	In the case of D2HGDH protein, the mutations I147S and V444A that are positioned in the beta sheet region exhibited higher Root Mean Square Deviation (RMSD), decrease in compactness and number of intramolecular hydrogen bonds compared to the mutations N439D and D375Y that are positioned in the turn and loop region, respectively.	Hydrogen	211-219	D-2-hydroxyglutarate dehydrogenase	Homo sapiens	15-21
28808919-2	2017	Here, we report the 1H, 15N, and 13C resonance assignments of Msi1 second RNA-binding domain in free form and in complex with RNA.	Hydrogen	20-22	musashi RNA binding protein 1	Homo sapiens	62-66
31352109-11	2019	This study uncovers for the first time the combinatory effect of slightly increased molecular hydrogen and the change in Mg2+/Ca2+ ratio on HGF cell migration.	Hydrogen	94-102	hepatocyte growth factor	Homo sapiens	140-143
28387464-4	2017	In this work, we reported the roles of a novel pH-controlled H2 S donor (JK-1) in NSAID-related gastric lesions.	Hydrogen	61-63	reticulophagy regulator 1	Homo sapiens	73-77
31601767-2	2019	Here, we report a direct electrosynthesis strategy that delivers separate hydrogen (H2) and oxygen (O2) streams to an anode and cathode separated by a porous solid electrolyte, wherein the electrochemically generated H+ and HO2 - recombine to form pure aqueous H2O2 solutions.	Hydrogen	74-82	heme oxygenase 2	Homo sapiens	224-227
28600983-8	2017	Structure-based molecular docking simulations indicated that HPW-RX40 binds to the active site of PDI by forming hydrogen bonds.	Hydrogen	113-121	prolyl 4-hydroxylase subunit beta	Homo sapiens	98-101
30058229-4	2018	We use as a model the YAP:TEAD interface, where one YAP (IDP) and two TEAD residues form hydrogen bonds via their side chain.	Hydrogen	89-97	Yes1 associated transcriptional regulator	Homo sapiens	22-25
30058229-4	2018	We use as a model the YAP:TEAD interface, where one YAP (IDP) and two TEAD residues form hydrogen bonds via their side chain.	Hydrogen	89-97	Yes1 associated transcriptional regulator	Homo sapiens	52-55
31601767-2	2019	Here, we report a direct electrosynthesis strategy that delivers separate hydrogen (H2) and oxygen (O2) streams to an anode and cathode separated by a porous solid electrolyte, wherein the electrochemically generated H+ and HO2 - recombine to form pure aqueous H2O2 solutions.	Hydrogen	84-86	heme oxygenase 2	Homo sapiens	224-227
28747437-7	2017	Intersubunit interactions involving 11 hydrogen bonds and numerous hydrophobic contacts account for stable complex formation with a buried surface area of 3094 A2 Comparative structural analysis of p59-p261C with the corresponding Polalpha complex revealed significant differences between the B-subunits and CTDs, as well as their interaction interfaces.	Hydrogen	39-47	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	231-239
31490645-4	2019	Through exploiting hydrogen evolution at the microneedle array, changes in local pH can induce swelling within the needle structure and could lay the foundations for a new approach to the smart device controlled delivery of therapeutic agents.	Hydrogen	19-27	phenylalanine hydroxylase	Homo sapiens	81-83
29018344-1	2017	Xanthates (alkyl or aryl derivatives of dithiocarbonic acid) have been shown to be selective mechanism-based inactivators of cytochromes P450 2B1/2B6 and 2E1 due to covalent binding of a reactive intermediate to apoprotein after double hydrogen abstraction at alpha-carbon atom, suggesting interaction of the xanthate dithiocarbonic head with the enzyme heme.	Hydrogen	236-244	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	125-157
30320260-9	2018	The analysis of the MD simulations shows hydrogen bonds for BT13 and significant hydrophobic interactions with GFRalpha1 for BT13 and BT18 at the allosteric site.	Hydrogen	41-49	GDNF family receptor alpha 1	Homo sapiens	111-120
31437794-6	2019	Computer-aided molecular docking predicted that DHA bound to PPARgamma via hydrogen bonding with residues Ser289, His323, Tyr473, and His499.	Hydrogen	75-83	peroxisome proliferator activated receptor gamma	Mus musculus	61-70
30077971-2	2018	X-ray structural features have suggested that CcO pumps protons via a mechanism involving electrostatic repulsions between pumping protons in the hydrogen-bond network of a proton-conducting pathway (the H-pathway) and net positive charges created upon oxidation of an iron site, heme a (Fe a2+), for reduction of O2 at another iron site, heme a3 (Fe a32+).	Hydrogen	146-154	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	46-49
28862847-3	2017	Five-coordinate Ir-H complexes generated by addition of triflic acid to (tBu)4(POCOP)Ir(CO) species show an Ir-H 1H NMR chemical shift dependence on the number of equivalents of acid present.	Hydrogen	113-115	C-X-C motif chemokine ligand 12	Homo sapiens	16-20
28862847-3	2017	Five-coordinate Ir-H complexes generated by addition of triflic acid to (tBu)4(POCOP)Ir(CO) species show an Ir-H 1H NMR chemical shift dependence on the number of equivalents of acid present.	Hydrogen	113-115	C-X-C motif chemokine ligand 12	Homo sapiens	108-112
30188552-1	2018	This work provides a rigorous procedure, within the framework of the Reaction Class Transition State Theory (RC-TST) and the Structure-Activity Relationship (SAR), for predicting reliable thermal rate constants on-the-fly for hydrogen abstraction reactions by methyl/ethyl radicals from Polycyclic Aromatic Hydrocarbons (PAHs) in a temperature range of 300-3000 K. All necessary RC-TST parameters were derived from ab initio calculations for a representative set of 36 reactions on which different error analyses and comparisons with available literature data were carried out.	Hydrogen	226-234	twister	Drosophila melanogaster	112-115
30431391-1	2019	According to the X-ray crystal structures of CYP17A1 (including its complexes with inhibitors), it is shown that a hydrogen bond exists between CYP17A1 and its inhibitors (such as abiraterone and TOK-001).	Hydrogen	115-123	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	45-52
30188552-1	2018	This work provides a rigorous procedure, within the framework of the Reaction Class Transition State Theory (RC-TST) and the Structure-Activity Relationship (SAR), for predicting reliable thermal rate constants on-the-fly for hydrogen abstraction reactions by methyl/ethyl radicals from Polycyclic Aromatic Hydrocarbons (PAHs) in a temperature range of 300-3000 K. All necessary RC-TST parameters were derived from ab initio calculations for a representative set of 36 reactions on which different error analyses and comparisons with available literature data were carried out.	Hydrogen	226-234	twister	Drosophila melanogaster	382-385
28612863-5	2017	In(OH)PDG exhibits strong intra- and interlayer hydrogen bonding, which prevents the layers from close packing and results in larger cylindrical pores running parallel to the indium hydroxide chains, producing a total accessible volume of 25% of the unit cell volume.	Hydrogen	48-56	phosphoglycerate dehydrogenase	Homo sapiens	6-9
30431391-1	2019	According to the X-ray crystal structures of CYP17A1 (including its complexes with inhibitors), it is shown that a hydrogen bond exists between CYP17A1 and its inhibitors (such as abiraterone and TOK-001).	Hydrogen	115-123	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	144-151
30017564-6	2018	Exposed bases of the aptamer interleave with the guanidinium groups of two arginines of Rev, forming stacking interactions and hydrogen bonds.	Hydrogen	127-135	Rev	Human immunodeficiency virus 1	88-91
30431391-4	2019	In the case of abiraterone binding, the unfilled volume in the active site cavity increases the freedom of movement of abiraterone within CYP17A1, leading to the collective motions of the helices G and B" as well as the breaking of hydrogen bond existing between the 3beta-OH group of abiraterone and N202 of CYP17A1.	Hydrogen	232-240	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	138-145
30431391-4	2019	In the case of abiraterone binding, the unfilled volume in the active site cavity increases the freedom of movement of abiraterone within CYP17A1, leading to the collective motions of the helices G and B" as well as the breaking of hydrogen bond existing between the 3beta-OH group of abiraterone and N202 of CYP17A1.	Hydrogen	232-240	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	309-316
31569521-2	2019	Its lipid inhibition effects indicated that the synthetic peptide PP1 exhibits a good inhibitory effect against porcine pancreatic lipase (PL) (47.95%) at 200 mug/mL, which could be attributed to its hydrogen binding into catalytic sites of PL (Ser153, Asp177, and His 264) by docking analysis.	Hydrogen	200-208	protein phosphatase 1 catalytic subunit gamma	Mus musculus	66-69
27900730-13	2018	The interactions between DNA and HMGB1 are defined by hydrogen bonds and van der Waals contacts.	Hydrogen	54-62	high mobility group box 1	Homo sapiens	33-38
28852144-6	2017	ELISA analyses showed that inhalation of hydrogen-oxygen mixed gas blocked CMS-induced increase in the serum levels of corticosterone, adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor-alpha in mice exposed to chronic mild stress.	Hydrogen	41-49	pro-opiomelanocortin-alpha	Mus musculus	135-162
31212267-5	2019	As for catalyst of oxygen evolution reaction, the reduced Co3O4 delivers a smaller potential of 1.55 V versus the reversible hydrogen electrode to realize a current density of 10 mA cm-2 and a lower Tafel slope of 71 mV dec-1 in alkaline solution, and these values are smaller than those of pristine Co3O4.	Hydrogen	125-133	deleted in esophageal cancer 1	Homo sapiens	220-225
28696262-8	2017	Examination of available sequence data suggests that Arg-135 may have originated for l-THA-like beta-elimination function in earlier evolutionary variants, and examination of available structural data suggests that a Ser84-H2O-Lys114 hydrogen-bonding network in human serine racemase lowers the pKa of the Ser84re-face base.	Hydrogen	234-242	serine racemase	Homo sapiens	268-283
29936999-6	2018	We hypothesized that T/HS results in the molecular association and nuclear colocalization of ALOX5 and ALOX5AP, which ultimately increases leukotriene production and potentiates lung injury.	Hydrogen	23-25	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	103-110
29853075-1	2018	New morpholine derived Schiff base ligands (HL1 and HL2) and their Cu(II) complexes [Cu(L1)2] (1) and [Cu(L2)2] (2) have been synthesized and characterized by 1H NMR, IR, UV-Vis, EPR studies and cyclic voltammetric analyses.	Hydrogen	159-161	intelectin 2	Homo sapiens	52-55
30294900-7	2018	We first demonstrated that GYY4137 (an H2 S donor molecule) directly suppresses ghrelin secretion in rat primary gastric culture, in part through the activation of the protein kinase B (AKT) pathway.	Hydrogen	39-41	ghrelin	Mus musculus	80-87
29892732-1	2018	The hydrogen abstraction reactions of phenyl formate (PF) by different radicals (H/O(3P)/OH/HO2) were theoretically investigated.	Hydrogen	4-12	heme oxygenase 2	Homo sapiens	92-95
29655151-0	2018	Fabrication of 2D SnS2/g-C3N4 heterojunction with enhanced H2 evolution during photocatalytic water splitting.	Hydrogen	59-61	sodium voltage-gated channel alpha subunit 11	Homo sapiens	18-22
29655151-4	2018	The H2 production rate over 5 wt% SnS2/g-C3N4 can reach 972.6 mumol h-1 g-1 under visible light irradiation (lambda &gt; 420 nm) using TEOA as the sacrifice agent and Pt as the electron trap, which is 2.9 and 25.6 times higher than those of the pristine g-C3N4 and SnS2, respectively.	Hydrogen	4-6	sodium voltage-gated channel alpha subunit 11	Homo sapiens	34-38
29655151-4	2018	The H2 production rate over 5 wt% SnS2/g-C3N4 can reach 972.6 mumol h-1 g-1 under visible light irradiation (lambda &gt; 420 nm) using TEOA as the sacrifice agent and Pt as the electron trap, which is 2.9 and 25.6 times higher than those of the pristine g-C3N4 and SnS2, respectively.	Hydrogen	4-6	sodium voltage-gated channel alpha subunit 11	Homo sapiens	265-269
29969902-3	2018	An association between axial anomer stability and the sum of 1H NMR downfield chemical shifts for protons H-3 and H-5 was observed in D2O with gluco- and galactopyranoses as reference compounds.	Hydrogen	61-63	septin 5	Homo sapiens	114-117
29979570-8	2018	Moreover, the Tafel slope of 58.9 mV dec-1 for hydrogen evolution reaction is also attained.	Hydrogen	47-55	deleted in esophageal cancer 1	Homo sapiens	37-42
30383070-2	2018	Among the different genes that are upregulated by hypoxia is carbonic anhydrase IX, which combines carbon dioxide and water to form bicarbonate and hydrogen.	Hydrogen	148-156	carbonic anhydrase 9	Homo sapiens	61-82
29458585-5	2018	The ring-opening mechanism of the rhodamine spirolactam was induced by Zn2+ binding, and the 3:1 stoichiometric structure between Rh6G-Cin and Zn2+ was adequately supported by the Job"s plot evaluation, optical titration and 1H NMR results.	Hydrogen	225-227	pyridoxal phosphatase	Homo sapiens	135-138
29633446-10	2018	Structural analysis of this variant suggested disruption of a critical hydrogen bond between insulin and the insulin receptor; however, the clinical picture in some individuals also suggested abnormal insulin processing and insulin deficiency.	Hydrogen	71-79	insulin receptor	Homo sapiens	109-125
30071584-5	2018	All results indicated that interactions occurred between the mucin and the HA, being stronger with HA 0.30%, due to the physical entanglements and hydrogen bounding.	Hydrogen	147-155	LOC100508689	Homo sapiens	61-66
30068164-7	2018	Almost 83% of atomic hydrogen elimination occurs through the asynchronous concerted mechanism from the terminal carbon atom via triple dissociation leading to CH3 + C2H4 + H products.	Hydrogen	21-29	COP9 signalosome subunit 3	Drosophila melanogaster	159-162
29897158-5	2018	Importantly, Ru SAs@PN is an excellent electrocatalyst for the hydrogen evolution reaction (HER) in 0.5 m H2 SO4 , delivering a low overpotential of 24 mV at 10 mA cm-2 and a Tafel slope of 38 mV dec-1 .	Hydrogen	63-71	deleted in esophageal cancer 1	Homo sapiens	196-201
30960654-7	2018	BET surface areas of solid products were 11.3, 98.5, and 183.9 m2/g for Ar., H2, and CO2 as the atmosphere, respectively.	Hydrogen	77-79	delta/notch like EGF repeat containing	Homo sapiens	0-3
29911863-5	2018	Furthermore, this MOF could behave as a highly active photocatalyst for H2 evolution without additional photosensitizers and cocatalyst.	Hydrogen	72-74	lysine acetyltransferase 8	Homo sapiens	18-21
29911863-6	2018	Remarkably, the as-prepared MOF shows enhanced photocatalytic Cr(VI) reduction and H2 evolution performances compared with the pristine light-harvesting ligand under the same conditions.	Hydrogen	83-85	lysine acetyltransferase 8	Homo sapiens	28-31
29988358-11	2018	Conclusions: Our results suggest that it is the first time to report the compound-1H with benzimidazoleisoquinolinone core playing antitumor activity in human glioblastoma cells by inhibiting Raf/MEK/ERK and PI3K/AKT signaling pathways, and it could be as a lead compound for the further development of targeted glioblastoma cancer therapy.	Hydrogen	82-84	zinc fingers and homeoboxes 2	Homo sapiens	192-195
29792704-0	2018	Double Hydrogen-Atom Exchange Reactions of HX (X = F, Cl, Br, I) with HO2.	Hydrogen	7-15	heme oxygenase 2	Homo sapiens	70-73
29946538-8	2018	Some of the derivatives showed good interaction with the active site of bacterial and neuraminidase enzymes through hydrogen, hydrophobic and pi-pi interactions, and could inhibit the activity of the selected enzymes.	Hydrogen	116-124	neuraminidase 1	Homo sapiens	86-99
29622678-6	2018	Structural differences between active (WT) and inactive (EF hand variant) CalDAG-GEFI protein were determined by hydrogen-deuterium exchange MS.	Hydrogen	113-121	RAS guanyl releasing protein 2	Homo sapiens	74-85
29680736-5	2018	Docking experiments exposed hydrogen bonding interactions with hinge region residues, salt bridge formation and l-l stacking interaction as the leading non-covalent interactions causative of the inhibitory activity of CDK4 inhibitors.	Hydrogen	28-36	cyclin dependent kinase 4	Homo sapiens	218-222
29750440-0	2018	3D Architectures of Cox P Using Silk Fibroin Scaffolds: An Active and Stable Electrocatalyst for Hydrogen Generation in Acidic and Alkaline Media.	Hydrogen	97-105	cytochrome c oxidase subunit 8A	Homo sapiens	20-23
29855822-6	2018	Here, we report vertical 1T-WS2 nanosheets as efficient catalysts for hydrogen evolution with low overpotential of 118 mV at 10 mA cm-2 and a Tafel slope of 43 mV dec-1.	Hydrogen	70-78	deleted in esophageal cancer 1	Homo sapiens	163-168
29738258-9	2018	Importantly, (kappa4-Ph2PPrPDI)Mn(mu-eta1,eta2-CO)K(18-crown-6) was found to react instantaneously with either HBF4 OEt2 or HOTf to evolve H2 and generate the corresponding Mn(I) complex, [(Ph2PPrPDI)Mn(CO)][BF4] or [(Ph2PPrPDI)Mn(CO)][OTf], respectively.	Hydrogen	139-141	DNA polymerase iota	Homo sapiens	42-46
29625198-4	2018	Both hydrogen-deuterium exchange mass spectrometry and molecular dynamics simulations indicate the formation of an interface between the N-terminal DNA-binding domains only in the RelA homodimer.	Hydrogen	5-13	RELA proto-oncogene, NF-kB subunit	Homo sapiens	180-184
29567338-5	2018	On the other hand, substituting hydrogen with deuterium produces a notable increase (~30%) in the molecules" half-lives in both rat and human microsomes, while maintaining sEH inhibition potency.	Hydrogen	32-40	epoxide hydrolase 2	Homo sapiens	172-175
29383749-8	2018	Subtle differences in the intra BB loop hydrogen bonding network between TLR3 and TLR2 are also observed.	Hydrogen	40-48	toll like receptor 3	Homo sapiens	73-77
29533404-0	2018	Reaction kinetics of hydrogen atom abstraction from isopentanol by the H atom and HO2  radical.	Hydrogen	21-29	heme oxygenase 2	Homo sapiens	82-85
29533404-4	2018	In this study, rate constants are determined for the hydrogen atom abstraction reactions from isopentanol by the H atom and HO2  radical by implementing the CBS-QB3 composite method.	Hydrogen	53-61	heme oxygenase 2	Homo sapiens	124-127
29533404-7	2018	The formation of hydrogen bonding is found to affect the kinetics of the H atom abstraction reactions by the HO2  radical.	Hydrogen	17-25	heme oxygenase 2	Homo sapiens	109-112
29533404-8	2018	Further above 750 K, the calculated high pressure limit rate constants indicate that the total contribution from delta carbon sites (Cdelta) is predominant for hydrogen atom abstraction by the H atom and HO2  radical.	Hydrogen	160-168	heme oxygenase 2	Homo sapiens	204-207
29406617-6	2018	Electrochemical properties were investigated and, upon electrolysis at 1.30 V versus a normal hydrogen electrode (NHE), both dioxygen production and oxygenation of the indane moiety were observed.	Hydrogen	94-102	solute carrier family 9 member C1	Homo sapiens	114-117
28861857-0	2018	1H, 13C and 15N resonance assignment of human guanylate kinase.	Hydrogen	0-2	guanylate kinase 1	Homo sapiens	46-62
29280056-0	2018	Assignment of 1H, 13C and 15N resonances and secondary structure of the Rgd1-RhoGAP domain.	Hydrogen	14-16	GTPase-activating protein RGD1	Saccharomyces cerevisiae S288C	72-76
29353448-0	2018	1H, 13C and 15N NMR assignments of cyclophilin LRT2 (OsCYP2) from rice.	Hydrogen	0-2	LOC100037525	Triticum aestivum	35-46
29353448-4	2018	Here, we report the backbone and sidechain resonance assignments of 1H, 13C, 15N in the LRT2 protein using several 2D and 3D heteronuclear NMR experiments at pH 6.7 and 298 K. Our chemical shift data analysis predicts a secondary structure like the cytosolic wheat cyclophilin TaCypA-1 with 87.7% sequence identity.	Hydrogen	68-70	LOC100037525	Triticum aestivum	265-276
29372459-0	2018	1H, 13C, 15N resonance assignment of human YAP 50-171 fragment.	Hydrogen	0-2	Yes1 associated transcriptional regulator	Homo sapiens	43-46
29453714-0	2018	Backbone 1H, 13C, and 15N assignments of the extracellular region of human Fcgamma receptor IIIb.	Hydrogen	9-11	Fc gamma receptor IIIb	Homo sapiens	75-96
29590585-6	2018	As a result, water-mediated hydrogen bonding remains an important form for Mg2+-RNA interaction.	Hydrogen	28-36	mucin 7, secreted	Homo sapiens	75-78
29527609-6	2018	Through the condition optimization, the enhanced electrocatalytic activity with an onset potential of 0.87 V versus the normal hydrogen electrode (NHE) towards oxygen evolution reaction with the highest Faradaic efficiency of 99% could be obtained.	Hydrogen	127-135	solute carrier family 9 member C1	Homo sapiens	147-150
31458596-12	2018	Upon activation, the initially formed [H-Bi-H]- ion transforms to an anionic eta2-H2 complex, which eliminates dihydrogen to form the bismuthide anion (Bi-).	Hydrogen	111-121	DNA polymerase iota	Homo sapiens	77-81
29292866-6	2018	Co2 P/WC@NC facilitated the generation of hydrogen in the electrolysis process, which had an overpotential of only 91 mV at a current density of 10 mA cm-2 in the acid solution; an excellent HER performance (2 H+ +2 e-  H2 ) and Tafel slope (40 mV dec-1 ) as well as durability over a period of 50 h were achieved.	Hydrogen	42-50	deleted in esophageal cancer 1	Homo sapiens	248-253
29546582-8	2018	Our simulation study showed that the A18-NA complex is as stable as the OTV-NA complex during the MD simulation of 50 ns through the analysis of RMSD, RMSF, total energy, hydrogen bonding, and MM/PBSA free energy calculations.	Hydrogen	171-179	neuraminidase 1	Homo sapiens	41-43
29499069-0	2018	Peptide Inhibitor of Complement C1 (PIC1) demonstrates antioxidant activity via single electron transport (SET) and hydrogen atom transfer (HAT).	Hydrogen	116-124	small ubiquitin like modifier 1	Homo sapiens	0-34
29499069-0	2018	Peptide Inhibitor of Complement C1 (PIC1) demonstrates antioxidant activity via single electron transport (SET) and hydrogen atom transfer (HAT).	Hydrogen	116-124	small ubiquitin like modifier 1	Homo sapiens	36-40
29487457-2	2018	Different interactions were observed between SSBP and xanthan at different pH (3-7) including electrostatic interactions and hydrogen bonding.	Hydrogen	125-133	single stranded DNA binding protein 1	Homo sapiens	45-49
29265027-8	2017	RESULTS: Molecular docking study revealed that cubebin was well bound within the binding site of the AChE enzyme showing interactions such as pi-pi stacking and hydrogen bonding with residues present therein.	Hydrogen	161-169	acetylcholinesterase	Mus musculus	101-105
28615457-4	2017	Here, we comprehensively analyze nucleotide binding to wild-type and mutant AMPK protein complexes by quantitative competition assays and by hydrogen-deuterium exchange MS. We also demonstrate that NADPH, in addition to the known AMPK ligand NADH, directly and competitively binds AMPK at the AMP-sensing CBS3 site.	Hydrogen	141-149	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	76-80
28506525-7	2017	Further examination of occurrences in these eight contexts led to the characterization of three different Mg2+ binding modes: 1) direct binding via N7 coordination, 2) direct binding via O6 coordination, and 3) binding via hydrogen-bonding interaction with the first-shell water molecules.	Hydrogen	223-231	mucin 7, secreted	Homo sapiens	106-109
28427888-6	2017	TPEN added 1h before, but not after, dopamine treatment suppressed the dopamine-induced elevation of LC3 II level.	Hydrogen	11-13	annexin A3	Rattus norvegicus	101-104
28608888-5	2017	In solution, 1 PF6 and 2 show acid/base-induced structural transformation due to the protonation/deprotonation of their pyridyl groups and/or imidazole units, which can be confirmed by their 1H NMR spectra.	Hydrogen	191-193	sperm associated antigen 17	Homo sapiens	15-24
28608888-9	2017	It was found that the amount of evolved hydrogen and the PS turnover number are 512 mumol and 102 for 1 PF6, and 131 mumol and 26 for 2, respectively.	Hydrogen	40-48	sperm associated antigen 17	Homo sapiens	104-107
28596568-0	2017	Influence of rovibrational excitation on the non-diabatic state-to-state dynamics for the Li(2p) + H2   LiH + H reaction.	Hydrogen	99-101	ATP binding cassette subfamily A member 12	Homo sapiens	90-95
28596568-5	2017	With the increase of the collision energy, the sideways and backward scattered tendencies of LiH for the Li(2p) + H2(v = 0, j = 0, 1)   LiH + H reactions are enhanced slightly, while the backward scattering tendency of LiH for the Li(2p) + H2(v = 1, j = 0)   LiH + H reaction becomes remarkably weakened.	Hydrogen	114-116	ATP binding cassette subfamily A member 12	Homo sapiens	105-110
28596568-5	2017	With the increase of the collision energy, the sideways and backward scattered tendencies of LiH for the Li(2p) + H2(v = 0, j = 0, 1)   LiH + H reactions are enhanced slightly, while the backward scattering tendency of LiH for the Li(2p) + H2(v = 1, j = 0)   LiH + H reaction becomes remarkably weakened.	Hydrogen	114-116	ATP binding cassette subfamily A member 12	Homo sapiens	231-236
28587205-6	2017	Moreover, NMR hydrogen-deuterium exchange measurements reveal that the backbone amides in Bet v 1.0102 are significantly more solvent exposed, in agreement with this isoform"s higher susceptibility to proteolytic cleavage.	Hydrogen	14-22	delta/notch like EGF repeat containing	Homo sapiens	90-93
28267170-2	2017	Here we report photocatalytic H2 production by a hybrid assembly of a sulfonate-functionalized [FeFe]-hydrogenase mimic (1) and CdSe quantum dot (QD), which is denoted as 1/beta-CD-6-S-CdSe (beta-CD-6-SH = 6-mercapto-beta-cyclodextrin).	Hydrogen	30-32	prostaglandin D2 receptor	Homo sapiens	168-172
28497772-4	2017	The modification of Fe-incorporated nitrogen-rich-carbons (Fe-CNx) on CNTs lowers the ORR half-wave-potential by ~190 mV, giving this catalyst with an onset ORR potential of 0.95 V (versus reversible hydrogen electrode (RHE)), a half-wave potential of 0.82 V (versus RHE), and the limiting current density of 5.39 mA cm-2 in 0.1 M KOH.	Hydrogen	200-208	calnexin	Homo sapiens	62-65
28550305-0	2017	Dynamics and ligand-induced conformational changes in human prolyl oligopeptidase analyzed by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	94-102	prolyl endopeptidase	Homo sapiens	60-81
28550305-5	2017	Here we used Hydrogen Deuterium eXchange Mass Spectrometry (HDX-MS) to derive the first near-residue resolution analysis of global PREP dynamics in the presence or absence of inhibitor bound in the active site.	Hydrogen	13-21	prolyl endopeptidase	Homo sapiens	131-135
28465432-10	2017	The same set of hydrogen bonds involving either the oxygen on phospho-Thr4 and the hydroxyl on Ser2, or the phosphate on Ser2 and the Thr4 hydroxyl, can be formed by rotation of an arginine side chain, leaving the intermolecular interface otherwise unperturbed.	Hydrogen	16-24	jagged canonical Notch ligand 2	Homo sapiens	95-99
28465432-10	2017	The same set of hydrogen bonds involving either the oxygen on phospho-Thr4 and the hydroxyl on Ser2, or the phosphate on Ser2 and the Thr4 hydroxyl, can be formed by rotation of an arginine side chain, leaving the intermolecular interface otherwise unperturbed.	Hydrogen	16-24	jagged canonical Notch ligand 2	Homo sapiens	121-125
28383885-5	2017	Herein, we have demonstrated a facile strategy for the regulation of stepwise intermolecular bond conversions from the metal-organic coordination bond (Cu-N) to the weak hydrogen bond (CH   N) by increasing the surface molecular coverage.	Hydrogen	170-178	chimerin 1	Homo sapiens	185-191
28442745-4	2017	Moreover, the crystal structure of LC3B in complex with the Nix LIR peptide containing glutamic acids as phosphomimetic residues and NMR experiments revealed that LIR phosphorylation stabilizes the Nix:LC3B complex via formation of two additional hydrogen bonds between phosphorylated serines of Nix LIR and Arg11, Lys49 and Lys51 in LC3B.	Hydrogen	247-255	microtubule associated protein 1 light chain 3 beta	Homo sapiens	35-39
28442745-4	2017	Moreover, the crystal structure of LC3B in complex with the Nix LIR peptide containing glutamic acids as phosphomimetic residues and NMR experiments revealed that LIR phosphorylation stabilizes the Nix:LC3B complex via formation of two additional hydrogen bonds between phosphorylated serines of Nix LIR and Arg11, Lys49 and Lys51 in LC3B.	Hydrogen	247-255	BCL2 interacting protein 3 like	Homo sapiens	60-63
28442745-4	2017	Moreover, the crystal structure of LC3B in complex with the Nix LIR peptide containing glutamic acids as phosphomimetic residues and NMR experiments revealed that LIR phosphorylation stabilizes the Nix:LC3B complex via formation of two additional hydrogen bonds between phosphorylated serines of Nix LIR and Arg11, Lys49 and Lys51 in LC3B.	Hydrogen	247-255	BCL2 interacting protein 3 like	Homo sapiens	198-201
28442745-4	2017	Moreover, the crystal structure of LC3B in complex with the Nix LIR peptide containing glutamic acids as phosphomimetic residues and NMR experiments revealed that LIR phosphorylation stabilizes the Nix:LC3B complex via formation of two additional hydrogen bonds between phosphorylated serines of Nix LIR and Arg11, Lys49 and Lys51 in LC3B.	Hydrogen	247-255	BCL2 interacting protein 3 like	Homo sapiens	198-201
28420213-4	2017	The SMA-FA conjugate was first synthesized and characterized by 1H NMR, FTIR and DSC.	Hydrogen	64-66	survival of motor neuron 1, telomeric	Homo sapiens	4-7
28332389-5	2017	Pt/octahedral PbS NCs with exposed PbS(111) facets show the highest photoinduced enhancement of hydrogen evolution reaction activity, which is ~14.38 times higher than that of the ones with only PbS(100) facets (Pt/cubic PbS NCs).	Hydrogen	96-104	cholinergic receptor muscarinic 3	Homo sapiens	14-17
28332389-5	2017	Pt/octahedral PbS NCs with exposed PbS(111) facets show the highest photoinduced enhancement of hydrogen evolution reaction activity, which is ~14.38 times higher than that of the ones with only PbS(100) facets (Pt/cubic PbS NCs).	Hydrogen	96-104	cholinergic receptor muscarinic 3	Homo sapiens	35-38
28332389-5	2017	Pt/octahedral PbS NCs with exposed PbS(111) facets show the highest photoinduced enhancement of hydrogen evolution reaction activity, which is ~14.38 times higher than that of the ones with only PbS(100) facets (Pt/cubic PbS NCs).	Hydrogen	96-104	cholinergic receptor muscarinic 3	Homo sapiens	35-38
28253447-6	2017	The onset for As(III) reduction at pH &lt;= 3.5 coincides with the potential for hydrogen electroadsorption on pyrite, E   +0.1 V (versus RHE).	Hydrogen	81-89	factor interacting with PAPOLA and CPSF1	Homo sapiens	138-141
28298086-0	2017	Ag2S/Ag Heterostructure: A Promising Electrocatalyst for the Hydrogen Evolution Reaction.	Hydrogen	61-69	angiotensin II receptor type 1	Homo sapiens	0-4
28298086-2	2017	In the present study, Ag2S/Ag is revealed as an efficient catalyst for hydrogen evolution.	Hydrogen	71-79	angiotensin II receptor type 1	Homo sapiens	22-26
28368283-4	2017	The crystal from which the human MnSOD data set was obtained is the crystal with the largest unit-cell edge (240 A) from which data have been collected via neutron diffraction to sufficient resolution (2.30 A) where hydrogen positions can be observed.	Hydrogen	216-224	superoxide dismutase 2	Homo sapiens	33-38
28091961-3	2017	Here we report the 1H, 13C and 15N backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2.	Hydrogen	19-21	zinc finger protein 763	Homo sapiens	88-91
28166210-5	2017	The polar spine residue and water network of AurA are essential for phosphorylation-driven activation, but an alternative form of the water network found in related kinases can support Tpx2-driven activation, suggesting that variations in the water-mediated hydrogen bond network mediate regulatory diversification in protein kinases.	Hydrogen	258-266	aurora kinase A	Homo sapiens	45-49
28265627-7	2017	In addition, cis-1,2-disulfide-bridged complex 3 can slowly convert into trans-1,2-disulfide-bridged complex 4 and the complex [Cp*Fe(mu-eta2:eta2-S2)(cis-mu-eta1:eta1-S2)FeCp*] (5) by self-assembly reaction at ambient temperature, which is evidenced by time-dependent 1H NMR spectroscopy.	Hydrogen	269-271	DNA polymerase iota	Homo sapiens	137-141
28265627-7	2017	In addition, cis-1,2-disulfide-bridged complex 3 can slowly convert into trans-1,2-disulfide-bridged complex 4 and the complex [Cp*Fe(mu-eta2:eta2-S2)(cis-mu-eta1:eta1-S2)FeCp*] (5) by self-assembly reaction at ambient temperature, which is evidenced by time-dependent 1H NMR spectroscopy.	Hydrogen	269-271	DNA polymerase iota	Homo sapiens	142-146
28267320-10	2017	The 1H NMR spectrum of [Nd(bpcd)]PF6 in D2O consists of eight considerably line-broadened, paramagnetic-shifted singlets.	Hydrogen	4-6	sperm associated antigen 17	Homo sapiens	33-36
28386317-4	2017	Our molecular docking showed that ALS preferentially bound AURKA over AURKB via hydrogen bond formation, charge interaction, and pi-pi stacking.	Hydrogen	80-88	aurora kinase A	Homo sapiens	59-64
28272449-7	2017	Moreover, the detailed interaction network of iso-PhABA/PYL10 was disclosed and involves hydrogen bonds and multiple hydrophobic interactions that provide a robust framework for the design of novel ABA receptor agonists/antagonists.	Hydrogen	89-97	PYR1-like 10	Arabidopsis thaliana	56-61
28003144-2	2017	Herein, we demonstrate a novel supramolecular poly(epsilon-caprolactone) (PCL) containing self-complementary sextuple hydrogen-bonded uracil-diamidopyridine (U-DPy) moieties, which undergoes spontaneous self-assembly to form supramolecular polymer networks.	Hydrogen	118-126	dumpy	Mus musculus	160-163
28189393-8	2017	This selectivity was also supported by computational docking models that suggest DY181 forms more extensive hydrogen bound network with ERRbeta which should result in higher binding affinity on ERRbeta over ERRgamma.	Hydrogen	108-116	estrogen related receptor gamma	Homo sapiens	207-215
28079952-1	2017	The reaction of nitrones with enals through iminium activation can be modulated by using cooperative hydrogen-bonding catalysis to induce the participation of a nitrone ylide (C-N-C) instead of the classical C-N-O dipole.	Hydrogen	101-109	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	176-181
28079952-1	2017	The reaction of nitrones with enals through iminium activation can be modulated by using cooperative hydrogen-bonding catalysis to induce the participation of a nitrone ylide (C-N-C) instead of the classical C-N-O dipole.	Hydrogen	101-109	biogenesis of lysosomal organelles complex 1 subunit 4	Homo sapiens	208-213
28121127-4	2017	The enhanced sorption kinetics of the nanocomposite is attributed to the synergistic catalytic effects of the in situ formed MgS, Ni and Mg2Ni multiple-phase catalysts during the hydrogenation/dehydrogenation process, the porthole effects for the volume expansion and microstrain of the phase transformation of Mg2Ni and Mg2NiH4 and the reduced hydrogen diffusion distance caused by nanosized Mg.	Hydrogen	179-187	MGS	Homo sapiens	125-128
28193005-0	2017	Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis.	Hydrogen	77-85	interleukin 37	Homo sapiens	45-59
28193005-3	2017	Here, we report the identification of an energetic epitope by determining the interfacial hot-spot that dominates the binding affinity for an anti-interleukin-23 (anti-IL-23) antibody by using the complementary approaches of hydrogen/deuterium exchange mass spectrometry (HDX-MS), fast photochemical oxidation of proteins (FPOP), alanine shave mutagenesis, and binding analytics.	Hydrogen	225-233	interleukin 37	Homo sapiens	147-161
28225078-6	2017	The tetrahedral electronic distribution around the N5 atom of FAD in b5R is stabilized by hydrogen bonding with CalphaH of Tyr65 and amide-H of Thr66.	Hydrogen	90-98	cytochrome b5 reductase 3	Homo sapiens	69-72
28107010-3	2017	The HBP water model describes hydrogen bonds between water and CO2 explicitly.	Hydrogen	30-38	heme binding protein 1	Homo sapiens	4-7
27566228-5	2017	While both hydroxylase and lyase substrates have similar orientations with respect to the heme, subtle differences in hydrogen bonding between CYP17A1 and the C3 substituent at the opposite end of ligands appear to correlate with differential substrate utilization and product formation.	Hydrogen	118-126	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	143-150
28093910-4	2017	A detailed analysis of the NMR spectra (including 2D experiments) revealed previously unknown effects associated with the existence of an intramolecular hydrogen bond (CH   N) between the six-membered ethene bridge and the azole substituents.	Hydrogen	153-161	chimerin 1	Homo sapiens	168-174
28155884-6	2017	Further computational modeling analysis shows that talin2 S339 formed a hydrogen bond with E353, which is critical for inducing key hydrogen bonds between talin2 N326 and beta1-integrin R760, and between talin2 K327 and beta1-integrin D759.	Hydrogen	72-80	talin 2	Homo sapiens	51-57
28155884-6	2017	Further computational modeling analysis shows that talin2 S339 formed a hydrogen bond with E353, which is critical for inducing key hydrogen bonds between talin2 N326 and beta1-integrin R760, and between talin2 K327 and beta1-integrin D759.	Hydrogen	72-80	talin 2	Homo sapiens	155-161
28155884-6	2017	Further computational modeling analysis shows that talin2 S339 formed a hydrogen bond with E353, which is critical for inducing key hydrogen bonds between talin2 N326 and beta1-integrin R760, and between talin2 K327 and beta1-integrin D759.	Hydrogen	72-80	talin 2	Homo sapiens	155-161
28155884-6	2017	Further computational modeling analysis shows that talin2 S339 formed a hydrogen bond with E353, which is critical for inducing key hydrogen bonds between talin2 N326 and beta1-integrin R760, and between talin2 K327 and beta1-integrin D759.	Hydrogen	132-140	talin 2	Homo sapiens	51-57
28155884-6	2017	Further computational modeling analysis shows that talin2 S339 formed a hydrogen bond with E353, which is critical for inducing key hydrogen bonds between talin2 N326 and beta1-integrin R760, and between talin2 K327 and beta1-integrin D759.	Hydrogen	132-140	talin 2	Homo sapiens	155-161
28155884-6	2017	Further computational modeling analysis shows that talin2 S339 formed a hydrogen bond with E353, which is critical for inducing key hydrogen bonds between talin2 N326 and beta1-integrin R760, and between talin2 K327 and beta1-integrin D759.	Hydrogen	132-140	talin 2	Homo sapiens	155-161
28155884-8	2017	These hydrogen bonds were not observed in talin1/beta1-integrin, but did exist in talin1C336S/beta1-integrin complex.	Hydrogen	6-14	talin 1	Homo sapiens	42-48
28155884-9	2017	These results suggest that talin2 S339 forms a hydrogen bond with E353 to mediate its high affinity to beta1-integrin.	Hydrogen	47-55	talin 2	Homo sapiens	27-33
31260766-4	2019	The results of three assays including circular dichroism, fluorescence, and Fourier transform infrared spectroscopy (FTIR) illustrated that these oligosaccharides could stabilize the secondary and tertiary structure of beta-Gal under thermal conditions through hydrogen bond interaction.	Hydrogen	261-269	galactosidase beta 1	Homo sapiens	219-227
31483550-5	2019	Results from obtained data showed that H2 S decreased the expression of SRA, Grp78, PERK, CHOP and Caspase-3, and increased that of LC3-II/LC3-I, in addition to alleviating the pathological changes of liver and reducing the levels of ALT, AST, LDH TBARS and MDA.	Hydrogen	39-41	caspase 3	Rattus norvegicus	99-108
31228295-6	2019	Specific variants in GAA, when investigated in the context of its protein structure, suggested gene-specific information like the disruption of local backbone torsional geometry and disruption of particular sidechain-sidechain hydrogen bonds as some potential sources for pathogenicity.	Hydrogen	227-235	alpha glucosidase	Homo sapiens	21-24
31305832-3	2019	The MOF was applied as an efficient bifunctional hydrogen-bonding catalyst for Michael additions of 1,3-dicarbonyl compounds to nitroalkenes in pure water, boosting the catalytic efficiency by up to approximately five times the value afforded by the homogeneous control and exhibiting a highly size-selective catalytic performance and good renewability.	Hydrogen	49-57	lysine acetyltransferase 8	Homo sapiens	4-7
31642258-5	2019	Through the fusion of SNAP-tag and the target protein, the probes could recognize the mitochondrial proteins (e. g., cytochrome oxidase, Cox8A) and nuclear proteins (e. g., H2B) in living cells.	Hydrogen	173-176	cytochrome c oxidase subunit 8A	Homo sapiens	137-142
30889560-3	2019	Upon hydrogen exposure, the molecular adsorption tuned the barrier height at the MoS2/GaN interface under the reverse biased condition, thus resulting in high sensitivity.	Hydrogen	5-13	gigaxonin	Homo sapiens	86-89
30889560-6	2019	The sensing mechanism was demonstrated based on an energy band diagram at the MoS2/GaN interface in the presence and absence of hydrogen exposure.	Hydrogen	128-136	gigaxonin	Homo sapiens	83-86
31853358-9	2019	Specifically, oncogenic upregulation for hydrogen-bonding amino acid substitutions (G12C, G12S) is achieved by stabilizing beta-interface interactions with Raf, while a bulkier, hydrophobic G12V substitution leads to destabilization of this interface and instead increases the proximity of residues along the alpha-helical bundles.	Hydrogen	41-49	zinc fingers and homeoboxes 2	Homo sapiens	156-159
27056562-6	2017	The evaluation of ligands was carried out by binding energy and weak interactions, such as hydrogen bond interactions and hydrophobic contacts, in the target site that favors LMTK3 inhibition.	Hydrogen	91-99	lemur tyrosine kinase 3	Homo sapiens	175-180
27999834-4	2017	The structure of the C18/EA/SMCC/FITC-g-PSI copolymer was confirmed using 1H-NMR and FTIR spectroscopy, and its cell binding ability was investigated by flow cytometry and confocal laser scanning microscopy.	Hydrogen	74-76	transgelin	Homo sapiens	28-32
31351645-3	2019	The results showed that CNC was covalently bonded to PUE, and specifically concerned with the hard segments of PUE resulting from the strong hydrogen bonding.	Hydrogen	141-149	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	24-27
28055194-2	2017	This work presents an example of that adding nonredox metal ions as Lewis acid can enhance dioxygen activation by oxidovanadium(IV) complex, [VIV(O)Cl(TPA)]PF6 (where TPA is tris-[(2-pyridy)methyl]amine), which leads to efficient hydrogen abstraction at ambient temperature, whereas, in the absence of a Lewis acid, the catalytic hydrogen abstraction of the oxidovanadium(IV) complex is very sluggish.	Hydrogen	230-238	sperm associated antigen 17	Homo sapiens	156-159
31082197-5	2019	A low coordination number and maximum utilization of the single molecular MoS2 surface enable MoS2-cPAN to demonstrate electrochemical performance significantly better than that of bulk MoS2 by two orders of exchange current density ( jo) and turnover frequency to the hydrogen evolution.	Hydrogen	269-277	DNA fragmentation factor subunit beta	Homo sapiens	99-103
27925347-1	2017	Co-crystallization of a cyanide-bridged tetranuclear complex [Co2 Fe2 ] with 4-cyanophenol (CP) gave a hydrogen bonding donor-acceptor system, [Co2 Fe2 (bpy*)4 (CN)6 (tp*)2 ](PF6 )2  2 CP 8 BN (1).	Hydrogen	103-111	sperm associated antigen 17	Homo sapiens	175-178
29454290-9	2018	Later, upon docking the active hits into the TrkA binding pocket, important interactions were revealed including hydrogen bonding with the amino acids Asp668 and Lys544 in addition to the cation-pi interactions with the sidechain of Arg559.	Hydrogen	113-121	neurotrophic receptor tyrosine kinase 1	Homo sapiens	45-49
30822754-1	2019	We report on a deep level transient spectroscopy study of annealing kinetics of a deep, vacancy-hydrogen related level, labeled E5*, at 0.42 eV below the conduction band in hydrogen-implanted n-type silicon.	Hydrogen	96-104	Rho guanine nucleotide exchange factor 15	Homo sapiens	128-131
28063424-2	2017	A step-like increase of the elastic constants of ice VIII phase occurred at 100-110 GPa due to hydrogen bond symmetrization.	Hydrogen	95-103	cytochrome c oxidase subunit 8A	Homo sapiens	53-57
30822754-1	2019	We report on a deep level transient spectroscopy study of annealing kinetics of a deep, vacancy-hydrogen related level, labeled E5*, at 0.42 eV below the conduction band in hydrogen-implanted n-type silicon.	Hydrogen	173-181	Rho guanine nucleotide exchange factor 15	Homo sapiens	128-131
27966717-5	2017	The formation of a type II heterojunction structure at the interface between Ag2S and MoS2 facilitates the separation of photogenerated charge carriers, and thus is responsible for the enhanced photoelectrocatalytic activity and photocatalytic H2 production rate (628 mumol h-1 g-1).	Hydrogen	244-246	angiotensin II receptor type 1	Homo sapiens	77-81
29347821-6	2018	Further, 3hECN exhibits a narrower fluorescence line shape and a larger quantum yield than CAN because its excited-state motions are hindered by a hydrogen bonding interaction between the 3"-hydroxyl group on its beta2 ring and Leu37 in the N-terminal domain.	Hydrogen	147-155	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	213-218
30822754-2	2019	The E5* annealing correlates with the formation of another commonly observed vacancy-hydrogen related level, labeled E5, at 0.45 eV below the conduction band.	Hydrogen	85-93	Rho guanine nucleotide exchange factor 15	Homo sapiens	4-7
31212801-5	2019	With a PVA nanodomain precursor (PS1/PVA 90/10 wt%), the integration of PVA nanodroplets on the AAO2 wall due to the hydrogen bonding that induces the phase separation between PS1-PVA results in the formation of VAPNs after removal of the PVA segment.	Hydrogen	117-125	taste 2 receptor member 62 pseudogene	Homo sapiens	33-46
29283561-4	2018	Here we show that the identity of the residue at position 202 in human CYP17A1, thought to form a hydrogen bond with the A-ring alcohol substituent on the pregnene- nucleus, is a key driver of this enzyme"s native preference for OHPREG.	Hydrogen	98-106	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	71-78
28215576-0	2017	Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model.	Hydrogen	71-79	interleukin-13	Cavia porcellus	20-25
28215576-2	2017	This study explored the possible roles of H2 on the pathogenesis of AR and observed the influences of H2 on cytokines IL-4 and IL-13.	Hydrogen	102-104	interleukin-13	Cavia porcellus	127-132
31212801-5	2019	With a PVA nanodomain precursor (PS1/PVA 90/10 wt%), the integration of PVA nanodroplets on the AAO2 wall due to the hydrogen bonding that induces the phase separation between PS1-PVA results in the formation of VAPNs after removal of the PVA segment.	Hydrogen	117-125	taste 2 receptor member 62 pseudogene	Homo sapiens	33-36
29266417-0	2018	MOF-Derived Bifunctional Cu3 P Nanoparticles Coated by a N,P-Codoped Carbon Shell for Hydrogen Evolution and Oxygen Reduction.	Hydrogen	86-94	lysine acetyltransferase 8	Homo sapiens	0-3
30785000-5	2019	The results of the biofilm community analyses suggested that Thauera was the dominant bacteria in the cathode biofilm of HPR and may prefer hydrogen as an electron donor for autotrophic denitrification, while the relative abundance of Pseudomonas were similar in the cathode biofilm and pyrite biofilm.	Hydrogen	140-148	haptoglobin-related protein	Homo sapiens	121-124
29073521-3	2018	Methanogens can consume H2 to produce CH4 in MECs, which has led to a drop of H2 production efficiency, H2 production rate (HPR) and also a low percentage of H2 in the produced biogas.	Hydrogen	24-26	haptoglobin-related protein	Homo sapiens	104-122
29073521-3	2018	Methanogens can consume H2 to produce CH4 in MECs, which has led to a drop of H2 production efficiency, H2 production rate (HPR) and also a low percentage of H2 in the produced biogas.	Hydrogen	24-26	haptoglobin-related protein	Homo sapiens	124-127
29040978-0	2017	Hydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3beta Signaling Pathway in Rats.	Hydrogen	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	150-158
30849493-7	2019	Surface-enhanced raman spectroscopy (SERS) indicated that nitration of hIAPP impaired the intermolecular hydrogen bonding.	Hydrogen	105-113	islet amyloid polypeptide	Homo sapiens	71-76
28008853-2	2016	Using Hydrogen-Deuterium Exchange-Mass Spectrometry (HDX-MS) we show that Ric-8A disrupts the secondary structure of the Galpha Ras-like domain that girds the guanine nucleotide-binding site, and destabilizes the interface between the Galphai1 Ras and helical domains, allowing domain separation and nucleotide release.	Hydrogen	6-14	RIC8 guanine nucleotide exchange factor A	Homo sapiens	74-80
29386581-0	2018	Hydrogen storage of Li4&amp;B36 cluster.	Hydrogen	0-8	lipase family member N	Homo sapiens	20-23
30849493-8	2019	On the basis of these results, we hypothesize that nitration of hIAPP may block the intermolecular hydrogen bonding, leading to the inhibition of its fibril formation.	Hydrogen	99-107	islet amyloid polypeptide	Homo sapiens	64-69
29386581-1	2018	The Saturn-like charge-transfer complex Li4&amp;B36, which was recently predicted with extensive first-principles theory calculations, were studied as a candidate for hydrogen storage material in the present work.	Hydrogen	167-175	lipase family member N	Homo sapiens	40-43
29386581-3	2018	Each Li atom in Li4&amp;B36 cluster can bind six H2 molecules at most, which results into the gravimetric density of 10.4%.	Hydrogen	49-51	lipase family member N	Homo sapiens	16-19
29386581-4	2018	The adsorption energies of H2 molecules on Li4&amp;B36 cluster are predicted in the range of 0.08-0.14 eV at the wB97x level of theory.	Hydrogen	27-29	lipase family member N	Homo sapiens	43-46
27989170-1	2016	A highly stable layered zirconium phosphate, (NH4)2[ZrF2(HPO4)2] (ZrP-1), was synthesized by an ionothermal method and contains an extremely dense two-dimensional hydrogen-bond network that is thermally stable up to 573 K, leading to combined ultrahigh water-assisted proton conductivities of 1.45 x 10-2 S cm-1 at 363 K/95% relative humidity and sustainable anhydrous proton conductivity of 1.1 x 10-5 S cm-1 at 503 K.	Hydrogen	163-171	thyroid hormone receptor interactor 6	Homo sapiens	66-71
30908780-7	2019	All systems can be used in the hydrogen evolution reaction (HER), where Cd7 P4 Cl6 has the highest activity and Cd3 PCl3 the lowest.	Hydrogen	31-39	PHD finger protein 19	Homo sapiens	116-120
27596062-0	2016	Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies.	Hydrogen	89-97	nuclear receptor subfamily 1 group H member 4	Homo sapiens	33-53
29382075-2	2018	The three-round systematic SAR exploration led to the discovery of a highly potent novel URAT1 inhibitor, 1h, which was 200- and 8-fold more potent than parent lesinurad and benzbromarone, respectively (IC50 = 0.035 muM against human URAT1 for 1h vs. 7.18 muM and 0.28 muM for lesinurad and benzbromarone, respectively).	Hydrogen	106-108	solute carrier family 22 member 12	Homo sapiens	89-94
29382075-2	2018	The three-round systematic SAR exploration led to the discovery of a highly potent novel URAT1 inhibitor, 1h, which was 200- and 8-fold more potent than parent lesinurad and benzbromarone, respectively (IC50 = 0.035 muM against human URAT1 for 1h vs. 7.18 muM and 0.28 muM for lesinurad and benzbromarone, respectively).	Hydrogen	106-108	solute carrier family 22 member 12	Homo sapiens	234-239
30990703-4	2019	The RPMD rate coefficients for H + H2O2   OH + H2O are larger than H + H2O2   H2 + HO2, but at very low temperatures below the room temperature, the H2 + HO2 channel becomes dominant due to significant quantum tunneling effects in the H atom transfer process.	Hydrogen	35-37	heme oxygenase 2	Homo sapiens	154-157
29382075-2	2018	The three-round systematic SAR exploration led to the discovery of a highly potent novel URAT1 inhibitor, 1h, which was 200- and 8-fold more potent than parent lesinurad and benzbromarone, respectively (IC50 = 0.035 muM against human URAT1 for 1h vs. 7.18 muM and 0.28 muM for lesinurad and benzbromarone, respectively).	Hydrogen	244-246	solute carrier family 22 member 12	Homo sapiens	89-94
29027272-4	2018	Compared with pure MoS2 , the MoS2 @HKUST-1 hybrids exhibit enhanced performance on hydrogen evolution reaction with an onset potential of -99 mV, a smaller Tafel slope of 69 mV dec-1 , and a Faradaic efficiency of nearly 100 %.	Hydrogen	84-92	deleted in esophageal cancer 1	Homo sapiens	178-183
27815120-5	2016	The binding mode analysis indicates that the activities of the inhibitors appear to be achieved by the establishment of multiple hydrogen bonds and hydrophobic interactions in the ATP-binding site of GSK3beta.	Hydrogen	129-137	glycogen synthase kinase 3 beta	Homo sapiens	200-208
30942073-12	2019	Hydrogen-bonded adducts of HO2 with the precursors, HO2 CH3OH and HO2 CH3CHO, played a role at lower temperatures; as part of this work, rate enhancements of the HO2 self-reaction due to reactions of the adducts with HO2 were also measured.	Hydrogen	0-8	heme oxygenase 2	Homo sapiens	52-55
27419805-8	2016	Our findings suggested that H2 S exacerbated taurocholate-induced AP by over-activating autophagy via activation of AMPK and subsequently, inhibition of mTOR.	Hydrogen	28-30	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	116-120
30942073-12	2019	Hydrogen-bonded adducts of HO2 with the precursors, HO2 CH3OH and HO2 CH3CHO, played a role at lower temperatures; as part of this work, rate enhancements of the HO2 self-reaction due to reactions of the adducts with HO2 were also measured.	Hydrogen	0-8	heme oxygenase 2	Homo sapiens	52-55
30942073-12	2019	Hydrogen-bonded adducts of HO2 with the precursors, HO2 CH3OH and HO2 CH3CHO, played a role at lower temperatures; as part of this work, rate enhancements of the HO2 self-reaction due to reactions of the adducts with HO2 were also measured.	Hydrogen	0-8	heme oxygenase 2	Homo sapiens	52-55
29215207-4	2018	As a result, the Pt@MOF/Au presents an exceptionally high photocatalytic H2 production rate by water splitting under visible light irradiation, far superior to Pt/MOF/Au, MOF/Au and other counterparts with similar Pt or Au contents, highlighting the important role of each component and the Pt location in the catalyst.	Hydrogen	73-75	lysine acetyltransferase 8	Homo sapiens	20-23
30685646-9	2019	Molecular docking study for the most potent cytotoxic compounds (7c and 8a-c) rationalized their superior CDK2 inhibitory activity through their hydrogen bonding and hydrophobic interactions with the key amino acids in the CDK2 binding site.	Hydrogen	145-153	cyclin dependent kinase 2	Homo sapiens	106-110
29848281-4	2018	METHOD: Owing to the potential role of GSK-3beta in nervous disorders, we have attempted to develop the quantitative four featured pharmacophore model comprising two Hydrogen Bond Acceptors (HBA), one Ring Aromatic (RA), and one Hydrophobe (HY), which were further affirmed by costfunction analysis, rm2 matrices, internal and external test set validation and Guner-Henry (GH) scoring analysis.	Hydrogen	166-174	glycogen synthase kinase 3 beta	Homo sapiens	39-48
27886256-5	2016	The structure shows that the Phe111, Leu113 and Phe114 residues of P2 insert into a hydrophobic pocket formed by the Tyr183, Arg235, Phe240 and Ile251 residues of RTA, while Asp115 of P2 forms hydrogen bonds with Arg235 of RTA.	Hydrogen	193-201	RNA binding fox-1 homolog 2	Homo sapiens	163-166
27777004-2	2016	This exercise identified a greatly simplified 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazole scaffold that afforded nanomolar inhibition of both activating peptide and gamma-thrombin mediated PAR4 stimulation, while reducing both molecular weight and the number of hydrogen bond donors/acceptors by ~50%.	Hydrogen	267-275	Prader Willi/Angelman region RNA 4	Homo sapiens	194-198
30772534-0	2019	One-pot aqueous synthesis of two-dimensional porous bimetallic PtPd alloyed nanosheets as highly active and durable electrocatalyst for boosting oxygen reduction and hydrogen evolution.	Hydrogen	166-174	protein tyrosine phosphatase receptor type D	Homo sapiens	63-67
29768885-1	2018	In this research work, 4,4"-(butane-1,4-diyl)bis(1-sulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium) tetrachloride (NS-C4(DABCO-SO3H)2   4Cl) as a new nano-sized N-sulfonic acid was prepared and characterized using different types of spectroscopic methods including FT-IR, 1H NMR, 13C NMR, XRD, TGA and SEM analysis.	Hydrogen	270-272	T-box transcription factor 1	Homo sapiens	292-295
30907580-2	2019	An exceptionally high Li-ion conductivity is found for the Li-B-H complex with 7.5 wt % H2 desorption under 3 bar H2 pressure, which reaches 2.7 x 10-4 S cm-1 at 35  C, more than 4 orders higher than that of LiBH4.	Hydrogen	88-90	leucine rich repeat containing 15	Homo sapiens	59-63
30422758-1	2018	Azo linked salicyldehyde and a new 2-hydroxy acetophenone based ligands (HL1 and HL2) with their copper(II) complexes [Cu(L1)2] (1) and [Cu(L2)2] (2) were synthesized and characterized by spectroscopic methods such as 1H, 13C NMR, UV-Vis spectroscopy and elemental analyses.	Hydrogen	218-220	intelectin 2	Homo sapiens	81-84
27727502-3	2016	We found that hydrogen bond interactions between the graft and the surface hydroxyl groups of the MOF are essential in determining the peptides conformation(s).	Hydrogen	14-22	lysine acetyltransferase 8	Homo sapiens	98-101
27723332-0	2016	Ion Aggregation and R3N+-C(R)-H   NR3 Hydrogen Bonding in a Fluorous Phase.	Hydrogen	38-46	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	34-37
27723332-4	2016	These observations are consistent with the formation of R3N+-C(R)-H   NR3 type hydrogen bonds between the nitrogen atom of the ionophore and the hydrogen atoms in the alpha position to the positively charged quaternary ammonium center of NBu4+.	Hydrogen	79-87	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	70-73
27723332-4	2016	These observations are consistent with the formation of R3N+-C(R)-H   NR3 type hydrogen bonds between the nitrogen atom of the ionophore and the hydrogen atoms in the alpha position to the positively charged quaternary ammonium center of NBu4+.	Hydrogen	145-153	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	70-73
30907580-2	2019	An exceptionally high Li-ion conductivity is found for the Li-B-H complex with 7.5 wt % H2 desorption under 3 bar H2 pressure, which reaches 2.7 x 10-4 S cm-1 at 35  C, more than 4 orders higher than that of LiBH4.	Hydrogen	114-116	leucine rich repeat containing 15	Homo sapiens	59-63
30238347-0	2019	1H, 15N and 13C resonance assignments of the C-terminal domain of the P protein of the Nishigahara strain of rabies virus.	Hydrogen	0-2	OCA2 melanosomal transmembrane protein	Homo sapiens	70-79
27544700-5	2016	Here we report results of an examination of the effects on the protein structure of ten pathogenic mutations of hE3 using hydrogen/deuterium-exchange mass spectrometry (HDX-MS), a new and state-of-the-art approach of solution structure elucidation.	Hydrogen	122-130	dihydrolipoamide dehydrogenase	Homo sapiens	112-115
27548075-10	2016	CONCLUSION AND IMPLICATIONS: Collectively, our results demonstrate that, by attenuating the phosphorylation of proteins downstream of FcepsilonRI cross-linking on mast cells, H2 S diminishes [Ca+2 ]i availability and thus mast cell degranulation and renin release.	Hydrogen	175-177	Fc epsilon receptor Ia	Homo sapiens	134-145
29138865-5	2018	Furthermore, silencing of ATP6V0C in PC-3M-1E8 cells inhibited V-ATPase activity (by ~5-fold), decreased extracellular hydrogen ion concentration and successively decreased activation of secreted MMP-9 (by ~3.6-fold), which coincided with the inhibition of cell migration and invasion in vitro, as well as a marked decrease in the expression of LASS2/TMSG1 probably through positive feedback.	Hydrogen	119-127	ATPase H+ transporting V0 subunit c	Homo sapiens	26-33
30238347-2	2019	Here we report the 1H, 13C and 15N chemical shift assignments of this domain from P protein of the Nishigahara strain of rabies virus, a pathogenic laboratory strain well established for studies of virulence functions of rabies virus proteins, including P protein.	Hydrogen	19-21	OCA2 melanosomal transmembrane protein	Homo sapiens	82-91
30242623-5	2019	Here, we report the 1H, 13C, and 15N resonance assignments of the isolated MBD domain of AtMBD6.	Hydrogen	20-22	methyl-CPG-binding domain 6	Arabidopsis thaliana	89-95
28738528-7	2017	Mutation of sod-2, sod-3, or aak-2 further suppressed the recovery effect of simulated microgravity toxicity in nematodes after simulated microgravity treatment for 1h.	Hydrogen	165-167	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	19-24
30284668-0	2019	1H, 15N, and 13C resonance assignments of the intrinsically disordered SH4 and Unique domains of Hck.	Hydrogen	0-2	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	97-100
28738528-7	2017	Mutation of sod-2, sod-3, or aak-2 further suppressed the recovery effect of simulated microgravity toxicity in nematodes after simulated microgravity treatment for 1h.	Hydrogen	165-167	5'-AMP-activated protein kinase catalytic subunit alpha-2	Caenorhabditis elegans	29-34
27518466-0	2016	Hydrogen-Rich Saline Attenuates Acute Hepatic Injury in Acute Necrotizing Pancreatitis by Inhibiting Inflammation and Apoptosis, Involving JNK and p38 Mitogen-Activated Protein Kinase-dependent Reactive Oxygen Species.	Hydrogen	0-8	mitogen activated protein kinase 14	Rattus norvegicus	147-183
27518466-9	2016	CONCLUSIONS: Hydrogen-rich saline plays a protective role in ANP-induced AHI through inhibiting inflammation and apoptosis, involving JNK and p38 MAPK-dependent reactive oxygen species.	Hydrogen	13-21	mitogen activated protein kinase 14	Rattus norvegicus	142-145
30284668-5	2019	Here, we report the 1H, 15N and 13C chemical shifts of the Hck SH4-Unique domains at pH 4.5.	Hydrogen	20-22	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-62
30836005-1	2019	Synthetic peroxo-bridged high-spin (HS) heme-(mu-eta2:eta1-O22-)-Cu(L) complexes incorporating (as part of the copper ligand) intramolecular hydrogen-bond (H-bond) capabilities and/or steric effects are herein demonstrated to affect the complex"s electronic and geometric structure, notably impacting the spin state.	Hydrogen	141-149	DNA polymerase iota	Homo sapiens	49-53
27833552-13	2016	H2 blocked the excessive expression of NADPH oxidase and the accumulation of ROS, attenuated the decrease of MMP, and inhibited ROS-sensitive ERK1/2, p38, and JNK signaling pathways.	Hydrogen	0-2	mitogen-activated protein kinase 3	Mus musculus	142-148
27833552-13	2016	H2 blocked the excessive expression of NADPH oxidase and the accumulation of ROS, attenuated the decrease of MMP, and inhibited ROS-sensitive ERK1/2, p38, and JNK signaling pathways.	Hydrogen	0-2	mitogen-activated protein kinase 14	Mus musculus	150-153
27833552-15	2016	H2 exerts its protective effects partially through blocking ROS-sensitive ERK1/2, p38, and JNK signaling pathways.	Hydrogen	0-2	mitogen-activated protein kinase 3	Mus musculus	74-80
27833552-15	2016	H2 exerts its protective effects partially through blocking ROS-sensitive ERK1/2, p38, and JNK signaling pathways.	Hydrogen	0-2	mitogen-activated protein kinase 14	Mus musculus	82-85
29286333-5	2017	In silico docking analysis of cyanidin and delphinidin, the core portions of the compound that fits within the ligand-binding pocket of ERbeta, showed that similarly to 17beta-estradiol, hydrogen bonds formed with the ERbeta residues Glu305, Arg346, and His475.	Hydrogen	187-195	estrogen receptor 2	Homo sapiens	136-142
29286333-5	2017	In silico docking analysis of cyanidin and delphinidin, the core portions of the compound that fits within the ligand-binding pocket of ERbeta, showed that similarly to 17beta-estradiol, hydrogen bonds formed with the ERbeta residues Glu305, Arg346, and His475.	Hydrogen	187-195	estrogen receptor 2	Homo sapiens	218-224
29200256-0	2017	A Novel Type of Battery-Supercapacitor Hybrid Device with Highly Switchable Dual Performances Based on a Carbon Skeleton/Mg2Ni Free-Standing Hydrogen Storage Electrode.	Hydrogen	141-149	mucin 7, secreted	Homo sapiens	121-124
27727349-2	2016	The investigated complexes, available in the form of PF6- salts, have been identified by means of FT-IR, 1H and 31P NMR spectroscopy and X-ray diffraction studies.	Hydrogen	105-107	sperm associated antigen 17	Homo sapiens	53-56
30640044-8	2019	Two major degradation products (DP2 and DP3) were isolated using preparative HPLC and their structures were confirmed by conducting 1H and 13C NMR experiments.	Hydrogen	132-134	APC regulator of WNT signaling pathway	Homo sapiens	40-43
27653243-6	2016	Stabilizing hydrogen bonds (H-bonds) formed by the hydroxyl substituent in 5hmC or from a bridging water in the 5mC structure provide approximately 1.5-2 kcal/mol per interaction of stability to the junction, which is mostly offset by entropy compensation, thereby leaving the overall stability of the G5hmCC and G5mCC constructs similar to that of the GCC core.	Hydrogen	12-20	guanylate cyclase 2C	Homo sapiens	353-356
29194993-0	2017	Nonstoichiometric Cux Iny S Quantum Dots for Efficient Photocatalytic Hydrogen Evolution.	Hydrogen	70-78	cut like homeobox 1	Homo sapiens	18-21
29194993-1	2017	Unlike their bulk counterpart, Cux Iny S quantum dots (QDs) prepared by an aqueous synthetic approach, show promising activity for photocatalytic hydrogen evolution, which is competitive with the state-of-the-art Cd chalcogen QDs.	Hydrogen	146-154	cut like homeobox 1	Homo sapiens	31-34
30858420-1	2019	The full length human histone 3 lysine 4 demethylase KDM5B (PLU-1/Jarid1B) has been studied using Hydrogen/Deuterium exchange mass spectrometry, homology modelling, sequence analysis, small angle X-ray scattering and electron microscopy.	Hydrogen	98-106	lysine demethylase 5B	Homo sapiens	53-58
29107538-5	2017	Hydrogen-deuterium exchange was used to map the Rag binding site to the outer face of the Lamtor2:Lamtor3 dimer and to the N-terminal intrinsically disordered region of Lamtor1.	Hydrogen	0-8	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	Homo sapiens	90-97
27711735-4	2016	Ultrathin nanoflakes having a minimized feature size exhibit the best photocurrent of 0.5 mA cm-2 (1.23 V vs. RHE, RHE is reversible hydrogen electrode) among the samples tested as a result of facilitated hole diffusion to the electrolyte and thus lowered carrier recombination.	Hydrogen	133-141	factor interacting with PAPOLA and CPSF1	Homo sapiens	110-113
27711735-4	2016	Ultrathin nanoflakes having a minimized feature size exhibit the best photocurrent of 0.5 mA cm-2 (1.23 V vs. RHE, RHE is reversible hydrogen electrode) among the samples tested as a result of facilitated hole diffusion to the electrolyte and thus lowered carrier recombination.	Hydrogen	133-141	factor interacting with PAPOLA and CPSF1	Homo sapiens	115-118
27830032-5	2016	Since H2O2 treatment activates MAPK, NF-kappaB and TGF-beta1 in cells, our study suggested that H2 could inhibit H2O2 activated MAPK and NF-kappaB activation as well as TGF-beta1 expression in treated cells.	Hydrogen	6-8	transforming growth factor, beta 1	Mus musculus	51-60
27830032-5	2016	Since H2O2 treatment activates MAPK, NF-kappaB and TGF-beta1 in cells, our study suggested that H2 could inhibit H2O2 activated MAPK and NF-kappaB activation as well as TGF-beta1 expression in treated cells.	Hydrogen	6-8	transforming growth factor, beta 1	Mus musculus	169-178
30764609-3	2019	The HOMO/LUMO energy levels are found to be distributed nearly symmetrically around the 0 V value versus normal hydrogen electrode (NHE), becoming more positive/negative, respectively, with increasing GQD size.	Hydrogen	112-120	solute carrier family 9 member C1	Homo sapiens	132-135
28946204-7	2017	These methanogens syntrophically support Syntrophobacter by degrading HPr catabolism by-products (H2 and acetate).	Hydrogen	98-100	haptoglobin-related protein	Homo sapiens	70-73
29166710-16	2017	(2) At PIH 24, the content of HMGB1 and IL-6 in serum and lung tissue of mice in hydrogen group was close to that in sham injury group (with P values above 0.05).	Hydrogen	81-89	high mobility group box 1	Mus musculus	30-35
30758362-2	2019	The resultant Mn-porphyrin-MoS2 exhibits excellent electrocatalytic activity toward the hydrogen evolution reaction, with a Tafel slope of 35 mV dec-1 and 10 mA cm-2 at an overpotential of 0.125 V. Spin-polarized density functional theory calculations confirmed that the intercalation of Mn-porphyrin into 1T"-MoS2 is quite favourable due to strong charge transfer from Mn metals.	Hydrogen	88-96	deleted in esophageal cancer 1	Homo sapiens	145-150
29166710-18	2017	The content of HMGB1 and IL-6 in serum and lung tissue of mice in burn+ hydrogen group was significantly lower than that in pure burn group (with P values below 0.001).	Hydrogen	72-80	high mobility group box 1	Mus musculus	15-20
27487322-5	2016	We found that the intrahelical hydrogen bond formed by the T202 hydroxyl group in the C-terminal zinc finger of TIS11d is necessary to allow for pi-pi stacking between the side chains of a conserved phenylalanine and the zinc-coordinating histidine.	Hydrogen	31-39	ZFP36 ring finger protein like 2	Homo sapiens	112-118
30765775-5	2019	Biochemical experiments, including mutation analysis and hydrogen-deuterium exchange assays, validated the binding of MCDC to MIF.	Hydrogen	57-65	macrophage migration inhibitory factor	Homo sapiens	126-129
27647193-9	2016	RESULTS: Immune POF model, model group exhibited markedly reduced serum AMH levels compared with those of the control group (5.41 +- 0.91 ng/ml vs. 16.23 +- 1.97 ng/ml, P = 0.033) and the hydrogen group (19.65 +- 7.82 ng/ml, P = 0.006).	Hydrogen	188-196	anti-Mullerian hormone	Mus musculus	72-75
27647193-10	2016	The model-hydrogen group displayed significantly higher AMH concentrations compared with that of the model group (15.03 +- 2.75 ng/ml vs. 5.41 +- 0.91 ng/ml, P = 0.021).	Hydrogen	10-18	anti-Mullerian hormone	Mus musculus	56-59
27647193-14	2016	CONCLUSIONS: Hydrogen-rich water may improve serum AMH levels and reduce ovarian GC apoptosis in a mouse immune POF model induced by ZP3.	Hydrogen	13-21	anti-Mullerian hormone	Mus musculus	51-54
28986508-5	2017	15N-1H heteronuclear single quantum coherence (HSQC) NMR studies reveal that these polysaccharides interact primarily with the F-face of the Gal-3 carbohydrate recognition domain.	Hydrogen	4-6	galectin 3	Homo sapiens	141-146
30736477-3	2019	Here we describe an extension of the technology by substituting 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) for cholesterol oxidase, making the method applicable to sterols with a 3alpha-hydroxy-5beta-hydrogen structure.	Hydrogen	88-96	aldo-keto reductase family 1 member C3	Homo sapiens	101-111
28692057-7	2017	Mechanistically, we demonstrate that CAIX associates with MMP14 through potential phosphorylation residues within its intracellular domain, and that CAIX enhances MMP14-mediated collagen degradation by directly contributing hydrogen ions required for MMP14 catalytic activity.	Hydrogen	224-232	carbonic anhydrase 9	Homo sapiens	149-153
28692057-7	2017	Mechanistically, we demonstrate that CAIX associates with MMP14 through potential phosphorylation residues within its intracellular domain, and that CAIX enhances MMP14-mediated collagen degradation by directly contributing hydrogen ions required for MMP14 catalytic activity.	Hydrogen	224-232	matrix metallopeptidase 14	Homo sapiens	163-168
28692057-7	2017	Mechanistically, we demonstrate that CAIX associates with MMP14 through potential phosphorylation residues within its intracellular domain, and that CAIX enhances MMP14-mediated collagen degradation by directly contributing hydrogen ions required for MMP14 catalytic activity.	Hydrogen	224-232	matrix metallopeptidase 14	Homo sapiens	163-168
27711538-0	2016	Concerted nitrogen inversion and hydrogen bonding to Glu451 are responsible for protein-controlled suppression of the reverse reaction in human DPP III.	Hydrogen	33-41	dipeptidyl peptidase 3	Homo sapiens	144-151
27711628-9	2016	In ice VIII the variance, and therefore the hydrogen bond strength, increases with pressure yielding a phase transition toward ice X in which the hydrogen bond is characterized as very strong.	Hydrogen	44-52	cytochrome c oxidase subunit 8A	Homo sapiens	7-11
27711628-9	2016	In ice VIII the variance, and therefore the hydrogen bond strength, increases with pressure yielding a phase transition toward ice X in which the hydrogen bond is characterized as very strong.	Hydrogen	146-154	cytochrome c oxidase subunit 8A	Homo sapiens	7-11
30650258-4	2019	The optimal ORR performance exhibits that onset potential and tafel slope can reach 0.937 V (vs reversible hydrogen electrode (RHE)) and 74 mV dec-1 , respectively, which is attributed to the synergistic effects of good electrical conductivity, large electrochemically active areas, and strong interfacial charge polarization.	Hydrogen	107-115	deleted in esophageal cancer 1	Homo sapiens	143-148
27529639-0	2016	Predicted Chemical Activation Rate Constants for HO2 + CH2NH: The Dominant Role of a Hydrogen-Bonded Pre-reactive Complex.	Hydrogen	85-93	heme oxygenase 2	Homo sapiens	49-52
27618313-6	2016	LY2874455, a type I inhibitor for FGFR4, binds to the ATP-binding pocket of FGFR4 in a DFG-in active conformation with three hydrogen bonds and a number of van der Waals contacts.	Hydrogen	125-133	fibroblast growth factor receptor 4	Homo sapiens	34-39
28898570-3	2017	Unfortunately, it has been quite challenging to explore a material with suitable band alignment using SnS2 nanomaterials for photocatalytic hydrogen generation.	Hydrogen	140-148	sodium voltage-gated channel alpha subunit 11	Homo sapiens	102-106
28898570-4	2017	Herein, a new strategy is used to systematically tailor the band alignment in SnS2 based heterostructure to realize efficient H2 production under sunlight.	Hydrogen	126-128	sodium voltage-gated channel alpha subunit 11	Homo sapiens	78-82
28898570-5	2017	A Type-I to Type-II band alignment transition is demonstrated via introducing an interlayer of Ce2 S3 , a potential photocatalyst for H2 evolution, between SnS2 and CeO2 .	Hydrogen	134-136	sodium voltage-gated channel alpha subunit 11	Homo sapiens	156-160
27618313-6	2016	LY2874455, a type I inhibitor for FGFR4, binds to the ATP-binding pocket of FGFR4 in a DFG-in active conformation with three hydrogen bonds and a number of van der Waals contacts.	Hydrogen	125-133	fibroblast growth factor receptor 4	Homo sapiens	76-81
30586302-5	2019	The resulting IL-1Ra/caspase-8(9) adducts are stabilized by hydrophobic and by few key hydrogen bonding interactions, formed by residues fully conserved across distinct caspases (-3, -6, -7, -8, and -9), and closely resemble the binding mode of the caspases inhibitors XIAP (X-linked inhibitor of apoptosis) and c-FLIP (cellular FLICE-like inhibitory protein).	Hydrogen	87-95	caspase 8	Homo sapiens	21-30
30460758-6	2019	Significantly, the optimized catalyst has a low onset potential of -42 mV versus reversible hydrogen electrode (RHE), a calculated Tafel slope of only 42 mV dec-1 , and good cycling stability of more than 40 h. This favored hydrogen evolution reaction (HER) activity is caused by the synergistic effects of MoO2 and PDDA-rGO, rapid charge transport, and sufficient exposed active sites of MoO2 /PDDA-rGO.	Hydrogen	224-232	deleted in esophageal cancer 1	Homo sapiens	157-162
27486675-3	2016	The interaction of the IL ions of [Rmim][NTf2] with water molecules through hydrogen bonding is suspected to disrupt IL ion layering and precursor film growth on mica.	Hydrogen	76-84	MHC class I polypeptide-related sequence A	Homo sapiens	162-166
27465104-7	2016	abstracts hydrogen rapidly from H2 O2 to produce HO2 (.)	Hydrogen	10-18	heme oxygenase 2	Homo sapiens	49-52
27500290-2	2016	In this work, we prepared Ni-Mn3O4 nanocomposites on Ni foam which exhibit an excellent hydrogen evolution reaction catalytic activity with a current density (j) of 10 mA cm(-2) at an overpotential (eta) of 91 mV and show good stability in an alkaline medium.	Hydrogen	88-96	endothelin receptor type A	Homo sapiens	199-202
27531909-4	2016	The quinone reductase inhibitor 2-n-heptyl-4-hydroxyquinoline-N-oxide (HQNO) was used to specifically inhibit the H2-utilizing respiratory chain of outer membrane-permeabilized bacterial cells; that level of inhibitor also greatly attenuated CagA translocation into AGS cells, indicating the H2-generated transmembrane potential is a contributor to toxin translocation.	Hydrogen	114-116	S100 calcium binding protein A8	Homo sapiens	242-246
27531909-11	2016	Delivery of the known carcinogenic factor CagA into host cells is augmented by the H2-utilizing respiratory chain of the bacterium.	Hydrogen	83-85	S100 calcium binding protein A8	Homo sapiens	42-46
26194018-7	2016	Furthermore, molecular docking studies of the active products into the HNE binding site revealed two types of HNE inhibitors: molecules with cinnolin-4(1H)-one scaffold, which were attacked by the HNE Ser195 hydroxyl group at the amido moiety, and cinnoline derivatives containing an ester function at C-4, which is the point of attack of Ser195.	Hydrogen	152-154	elastase, neutrophil expressed	Homo sapiens	71-74
26194018-7	2016	Furthermore, molecular docking studies of the active products into the HNE binding site revealed two types of HNE inhibitors: molecules with cinnolin-4(1H)-one scaffold, which were attacked by the HNE Ser195 hydroxyl group at the amido moiety, and cinnoline derivatives containing an ester function at C-4, which is the point of attack of Ser195.	Hydrogen	152-154	elastase, neutrophil expressed	Homo sapiens	110-113
26194018-7	2016	Furthermore, molecular docking studies of the active products into the HNE binding site revealed two types of HNE inhibitors: molecules with cinnolin-4(1H)-one scaffold, which were attacked by the HNE Ser195 hydroxyl group at the amido moiety, and cinnoline derivatives containing an ester function at C-4, which is the point of attack of Ser195.	Hydrogen	152-154	elastase, neutrophil expressed	Homo sapiens	110-113
26804000-4	2016	At high concentrations, H2 S augments Cav3.2 currents, an observation which has led to the suggestion that H2 S exerts its pro-nociceptive effects via this channel, since Cav3.2 plays a central role in sensory nerve excitability.	Hydrogen	24-26	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	38-44
26804000-4	2016	At high concentrations, H2 S augments Cav3.2 currents, an observation which has led to the suggestion that H2 S exerts its pro-nociceptive effects via this channel, since Cav3.2 plays a central role in sensory nerve excitability.	Hydrogen	24-26	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	171-177
26804000-4	2016	At high concentrations, H2 S augments Cav3.2 currents, an observation which has led to the suggestion that H2 S exerts its pro-nociceptive effects via this channel, since Cav3.2 plays a central role in sensory nerve excitability.	Hydrogen	107-109	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	38-44
26804000-4	2016	At high concentrations, H2 S augments Cav3.2 currents, an observation which has led to the suggestion that H2 S exerts its pro-nociceptive effects via this channel, since Cav3.2 plays a central role in sensory nerve excitability.	Hydrogen	107-109	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	171-177
27374698-6	2016	The results obtained provide experimental support for the strength of hydrogen bonds between the alcohols and the NTf2 and PF6 anions, providing insights into the IL intermolecular interactions, namely by indicating the ability of the alcohols to discriminate the IL anion hydrogen bond basicity.	Hydrogen	273-281	sperm associated antigen 17	Homo sapiens	123-126
28742947-3	2017	The dendritic nanostructure of this photoanode with an increased solid-liquid junction area further improves the surface charge collection efficiency, generating a photocurrent of about 2.5 mA cm-2 at 1.23 V versus the reversible hydrogen electrode (vs. RHE) under air mass 1.5G illumination.	Hydrogen	230-238	factor interacting with PAPOLA and CPSF1	Homo sapiens	254-257
28807355-12	2017	These results demonstrated that H2-rich pure water attenuated CS-induced emphysema in SMP30-KO mice by reducing CS-induced oxidative DNA damage and premature cell senescence in the lungs.	Hydrogen	32-34	regucalcin	Mus musculus	86-91
27070271-5	2017	The results showed that the increase in IP3 after HS was partially dependent on AtPLC3 activity.	Hydrogen	50-52	phospholipase C1	Arabidopsis thaliana	80-86
28873669-2	2017	The hydrolysate generated with Corolase PP for 1h (SG-C1) had the highest angiotensin converting enzyme (ACE, IC50=0.13+-0.05mgmL-1) and dipeptidyl peptidase IV (DPP-IV, IC50=0.08+-0.01mgmL-1) inhibitory activities, and oxygen radical absorbance capacity (ORAC, 540.94+-9.57mumolTEg-1d.w.).	Hydrogen	47-49	dipeptidylpeptidase 4	Rattus norvegicus	137-160
28873669-2	2017	The hydrolysate generated with Corolase PP for 1h (SG-C1) had the highest angiotensin converting enzyme (ACE, IC50=0.13+-0.05mgmL-1) and dipeptidyl peptidase IV (DPP-IV, IC50=0.08+-0.01mgmL-1) inhibitory activities, and oxygen radical absorbance capacity (ORAC, 540.94+-9.57mumolTEg-1d.w.).	Hydrogen	47-49	dipeptidylpeptidase 4	Rattus norvegicus	162-168
28723093-6	2017	We compare the photocatalytic rates of H2 generation with and without Pt cocatalysts added to Au-TiO2 aerogels and demonstrate electrochemical linkage of the SPR-generated carriers at the Au TiO2 interfaces to downfield Pt nanoparticle cocatalysts.	Hydrogen	39-41	sepiapterin reductase	Homo sapiens	158-161
28803477-4	2017	An evaluation of the effect of coordination on the ionic hydration microstructures for both nanopores showed that the positioning of the modified groups could better fit a hydrated Mg2+ than a hydrated Li+, as if Mg2+ was not dehydrated according to hydrogen bond analysis of the ionic hydration shells.	Hydrogen	250-258	mucin 7, secreted	Homo sapiens	181-184
28816457-0	2017	A Coupled Cluster Investigation of SNO Radical Isomers and Their Reactions with Hydrogen Atom: Insight into Structures, Conformers, Barriers, and Energetics.	Hydrogen	80-88	strawberry notch homolog 1	Homo sapiens	35-38
28816457-4	2017	The CCSD(T)/aug-cc-pV5Z//CCSD(T)/aug-cc-pVTZ results suggest that the reaction between SNO radical isomers and hydrogen atom result in the formation of their [H,N,S,O] hydrides with HNSO hydrides being the most stable ones.	Hydrogen	111-119	strawberry notch homolog 1	Homo sapiens	87-90
28966947-7	2017	The structural integrity of the final recombinant p300-CH1 has been verified to be optimal using onedimensional 1H NMR spectroscopy and circular dichroism.	Hydrogen	112-114	E1A binding protein p300	Homo sapiens	50-54
28234792-0	2017	Hydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release.	Hydrogen	0-8	high mobility group box 1	Mus musculus	130-135
28234792-9	2017	The results showed that therapy with 2% H2 increased the survival rate, alleviated the injuries caused by oxidative stress and inflammation, reduced HMGB1 levels but increased HO-1 levels in WT septic mice, but not in Nrf2-KO mice.	Hydrogen	40-42	high mobility group box 1	Mus musculus	149-154
28234792-10	2017	These data demonstrate that 2% H2 inhalation may be a promising therapeutic strategy for intestinal injuries caused by severe sepsis through the regulation of HO-1 and HMGB1 release.	Hydrogen	31-33	high mobility group box 1	Mus musculus	168-173
28783328-0	2017	Single-Crystal Time-of-Flight Neutron Diffraction and Magic-Angle-Spinning NMR Spectroscopy Resolve the Structure and 1H and 7Li Dynamics of the Uranyl Peroxide Nanocluster U60.	Hydrogen	118-120	small nucleolar RNA, C/D box 60	Homo sapiens	173-176
30578314-5	2019	Here, we identify an amphipathic helix named H2 as a novel vinculin-binding site in vinexin alpha.	Hydrogen	45-47	vinculin	Homo sapiens	59-67
30447027-4	2019	Remarkably, Cu@Cu3 P/NF-50, with a molar ratio of Cu/Cu3 P of around 2.63, reveals a highly efficient catalytic performance for the hydrogen evolution reaction in alkaline solution with a Tafel slope of 59 mV dec-1 and a long durability of 48 h. Overpotentials as low as 218 and 302 mV are required to reach current densities of 10 and 100 mA cm-2 , respectively.	Hydrogen	132-140	deleted in esophageal cancer 1	Homo sapiens	209-214
33266801-5	2019	The effects of the temperature, the hydrogen utilization factor at the anode, and the molar ratio of the syngas into burner and steam reformer on the performance of a PEM fuel cell are discussed.	Hydrogen	36-44	mucin 1, cell surface associated	Homo sapiens	167-170
31459403-2	2019	In particular, NMR 1H and pulsed-field gradient spin-echo titrations allowed us to characterize the hydrogen bond (HB) between the -NH2 moieties of SeU and the anions PF6 - and ClO4 -, whereas 77Se NMR spectroscopy allowed us to characterize the Au-Se bond.	Hydrogen	100-108	sperm associated antigen 17	Homo sapiens	167-170
28819260-8	2017	The observations suggest decreased RNA hydrogen bonding and changed RNA conformation upon IRP1 binding and illustrate how small, conserved, sequence differences among IRE-mRNAs selectively influence thermodynamic and kinetic selectivity of the protein/RNA interactions.	Hydrogen	39-47	aconitase 1	Homo sapiens	90-94
31655738-2	2019	In cases where zero-valent (elemental) sulfur, sulfate and other oxidized forms are used as electron acceptor in (primarily) anaerobic microbial metabolisms, the end product is hydrogen sulfide (HS- or H2S, dependent on pH).	Hydrogen	195-197	phenylalanine hydroxylase	Homo sapiens	220-222
28585804-6	2017	While electrostatic interactions are main attractive forces to drive the hIAPP aggregates to adsorb on both bilayers, the introduction of the more hydrophilic head groups of POPE lipids further promote the formation of the interfacial hydrogen bonds.	Hydrogen	235-243	islet amyloid polypeptide	Homo sapiens	73-78
28796245-9	2017	Moreover, the molecular docking assay showed that dioscin processed powerful affinity toward to ERbeta mainly through the strong hydrogen bonding and hydrophobic effects, and the actions of dioscin on ERbeta activation and tumor cells inhibition were significantly weakened in the mutational (Phe-336, Phe-468) PC3 cells.	Hydrogen	129-137	estrogen receptor 2 (beta)	Mus musculus	96-102
29946833-1	2019	To recover a nitrogen resource from high-ammonia-nitrogen wastewater, two amphitrophic hydrogen-oxidizing bacteria (HOB), Paracoccus denitrificans Y5 and P. versutus D6, capable of nitrogen assimilation for single-cell protein (SCP) production were isolated.	Hydrogen	87-95	urocortin 3	Homo sapiens	228-231
28796245-9	2017	Moreover, the molecular docking assay showed that dioscin processed powerful affinity toward to ERbeta mainly through the strong hydrogen bonding and hydrophobic effects, and the actions of dioscin on ERbeta activation and tumor cells inhibition were significantly weakened in the mutational (Phe-336, Phe-468) PC3 cells.	Hydrogen	129-137	estrogen receptor 2 (beta)	Mus musculus	201-207
29885845-0	2019	FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia.	Hydrogen	83-91	forkhead box O1	Rattus norvegicus	0-5
30155226-3	2017	In this study, Fl incorporated into a short peptide, flavopeptide (Fl-Pep), was designed by a rational top-down approach using a computational method, which could stabilize the corresponding 4a-hydroperoxy adduct (FlOOH-Pep) through intramolecular hydrogen bonds.	Hydrogen	248-256	prolyl endopeptidase	Homo sapiens	70-73
30155226-3	2017	In this study, Fl incorporated into a short peptide, flavopeptide (Fl-Pep), was designed by a rational top-down approach using a computational method, which could stabilize the corresponding 4a-hydroperoxy adduct (FlOOH-Pep) through intramolecular hydrogen bonds.	Hydrogen	248-256	prolyl endopeptidase	Homo sapiens	220-223
28461893-4	2016	Presented in this article, along with only the second neutron structure of a clinical drug-bound hCA, is an in-depth structural comparison and analyses of differences in hydrogen-bonding network, water-molecule orientation and solvent displacement that take place upon the binding of AZM and MZM in the active site of hCA II.	Hydrogen	170-178	HCA1	Homo sapiens	97-100
27282318-5	2016	Specifically, the photocatalytic hydrogen evolution rate per mole of CN was found to be 11 times higher for the CN/SNO composite compared to pristine CN.	Hydrogen	33-41	strawberry notch homolog 1	Homo sapiens	115-118
29885845-12	2019	FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of VD.	Hydrogen	83-91	forkhead box O1	Rattus norvegicus	0-5
28695953-7	2017	Addition of NEt3 attenuated the water and alcohol loss from 5-9 to allow 1H, 13C, 31P, and 11B NMR data to be collected for all the compounds, confirming the determined structures.	Hydrogen	73-75	tetraspanin 2	Homo sapiens	12-16
30204870-4	2019	15N-1H HSQC NMR studies with 15N-labeled Gal-3 carbohydrate recognition domain (CRD) indicate that each of these galactans interacts primarily with residues in beta-strands 4, 5 and 6 on the canonical, beta-galactoside sugar binding S-face.	Hydrogen	4-6	galectin 3	Homo sapiens	41-46
27249784-1	2016	A chromium(II)-based metal-organic framework Cr3 [(Cr4 Cl)3 (BTT)8 ]2 (Cr-BTT; BTT(3-) =1,3,5-benzenetristetrazolate), featuring coordinatively unsaturated, redox-active Cr(2+) cation sites, was synthesized and investigated for potential applications in H2 storage and O2 production.	Hydrogen	254-256	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	45-48
27406992-6	2016	Under solar-light irradiation, the optimized H-TiO2 120(H2-plasma treatment time: 120 min) photocatalysts showed unprecedentedly excellent removal capability for phenol (Ph), reactive black 5(RB 5), rhodamine B (Rho B) and methylene blue (MB) - approximately four-times higher than those of the other photocatalysts (a-TiO2 and P25) - resulting in complete purification of the water.	Hydrogen	56-58	ras homolog family member B	Homo sapiens	199-210
30204870-6	2019	Following assignment of galactan 13C and 1H resonances using HSQC, HMBC and TOCSY experiments, we used 13C-1H HSQC data to demonstrate that the Gal-3 CRD binds to the terminal, non-reducing end of these galactans, regardless of their size, but with binding affinity increasing as the galactan chain length increases.	Hydrogen	41-43	galectin 3	Homo sapiens	144-149
27406992-6	2016	Under solar-light irradiation, the optimized H-TiO2 120(H2-plasma treatment time: 120 min) photocatalysts showed unprecedentedly excellent removal capability for phenol (Ph), reactive black 5(RB 5), rhodamine B (Rho B) and methylene blue (MB) - approximately four-times higher than those of the other photocatalysts (a-TiO2 and P25) - resulting in complete purification of the water.	Hydrogen	56-58	ras homolog family member B	Homo sapiens	212-217
30204870-6	2019	Following assignment of galactan 13C and 1H resonances using HSQC, HMBC and TOCSY experiments, we used 13C-1H HSQC data to demonstrate that the Gal-3 CRD binds to the terminal, non-reducing end of these galactans, regardless of their size, but with binding affinity increasing as the galactan chain length increases.	Hydrogen	107-109	galectin 3	Homo sapiens	144-149
30453148-10	2019	Furthermore, molecular modeling suggested that EC suppressed p38 MAPK signaling by hydrogen bonding with Glu71, Ala 111, Asp112, and Leu171 in the active site of p38alpha.	Hydrogen	83-91	mitogen-activated protein kinase 14	Mus musculus	61-64
27143440-7	2016	A western blot analysis revealed that Res treatment at 1h before ischemia significantly increased ERK1/2 phosphorylation and cyclic-AMP response element binding protein (CREB) phosphorylation in the CA1 region of the hippocampus, which can be prevented with U0126 pretreatment.	Hydrogen	55-57	mitogen activated protein kinase 3	Rattus norvegicus	98-104
28678159-3	2017	Our results show that PHF, HMB, and DHMBP formed a partial hydrogen bond with GluR2 in its ligand-binding domain.	Hydrogen	59-67	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	78-83
30453148-10	2019	Furthermore, molecular modeling suggested that EC suppressed p38 MAPK signaling by hydrogen bonding with Glu71, Ala 111, Asp112, and Leu171 in the active site of p38alpha.	Hydrogen	83-91	mitogen-activated protein kinase 14	Mus musculus	162-170
28297133-8	2017	Our study demonstrates the inhibitory mechanism of EGCG on fibrillation and aggregation of hIAPP-NH2 in which EGCG interacts with hIAPP-NH2 through hydrogen bonding and pi-pi interactions between the A ring and residue Phe23 as well as hydrophobic interactions between the A ring and residue Ile26, which can thus inhibit the interpeptide interaction between hIAPP-NH2 monomers and finally inhibit fibrillation of hIAPP-NH2 .	Hydrogen	148-156	islet amyloid polypeptide	Homo sapiens	91-96
28297133-8	2017	Our study demonstrates the inhibitory mechanism of EGCG on fibrillation and aggregation of hIAPP-NH2 in which EGCG interacts with hIAPP-NH2 through hydrogen bonding and pi-pi interactions between the A ring and residue Phe23 as well as hydrophobic interactions between the A ring and residue Ile26, which can thus inhibit the interpeptide interaction between hIAPP-NH2 monomers and finally inhibit fibrillation of hIAPP-NH2 .	Hydrogen	148-156	islet amyloid polypeptide	Homo sapiens	130-135
28297133-8	2017	Our study demonstrates the inhibitory mechanism of EGCG on fibrillation and aggregation of hIAPP-NH2 in which EGCG interacts with hIAPP-NH2 through hydrogen bonding and pi-pi interactions between the A ring and residue Phe23 as well as hydrophobic interactions between the A ring and residue Ile26, which can thus inhibit the interpeptide interaction between hIAPP-NH2 monomers and finally inhibit fibrillation of hIAPP-NH2 .	Hydrogen	148-156	islet amyloid polypeptide	Homo sapiens	130-135
30145443-4	2019	It is concluded that nanofibrous metal oxide structured Co3O4/Nfs-1 composite provides the best catalytic activity in terms of hydrogen production rate with 2.54 l H2 min-1 gcat-1 and good repeatability.	Hydrogen	127-135	NFS1 cysteine desulfurase	Homo sapiens	62-67
28297133-8	2017	Our study demonstrates the inhibitory mechanism of EGCG on fibrillation and aggregation of hIAPP-NH2 in which EGCG interacts with hIAPP-NH2 through hydrogen bonding and pi-pi interactions between the A ring and residue Phe23 as well as hydrophobic interactions between the A ring and residue Ile26, which can thus inhibit the interpeptide interaction between hIAPP-NH2 monomers and finally inhibit fibrillation of hIAPP-NH2 .	Hydrogen	148-156	islet amyloid polypeptide	Homo sapiens	130-135
27322598-0	2016	Engineering the Electronic Structure of 2D WS2 Nanosheets Using Co Incorporation as Cox W(1- x ) S2 for Conspicuously Enhanced Hydrogen Generation.	Hydrogen	127-135	cytochrome c oxidase subunit 8A	Homo sapiens	84-87
27322598-6	2016	Benefiting from the modification in the electronic structure, the resultant material requires overpotential of 121 mV versus reversible hydrogen electrode (RHE) to achieve current density of 10 mA cm(-2) and shows Tafel slope of 67 mV dec(-1) .	Hydrogen	136-144	deleted in esophageal cancer 1	Homo sapiens	235-241
27302079-7	2016	Structural analysis and free energy calculations showed that the most important determinants of regioselectivity among the CYP2C isoforms are the geometrical features of the active sites, as well as the hydrogen bonds and the hydrophobic interactions, mainly presenting as the various locations of Arg108 and substitutions of Phe205 for Ile205 in CYP2C8.	Hydrogen	203-211	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	347-353
28540718-0	2017	Oriented Built-in Electric Field Introduced by Surface Gradient Diffusion Doping for Enhanced Photocatalytic H2 Evolution in CdS Nanorods.	Hydrogen	109-111	solute carrier family 22 member 5	Homo sapiens	125-128
30145443-4	2019	It is concluded that nanofibrous metal oxide structured Co3O4/Nfs-1 composite provides the best catalytic activity in terms of hydrogen production rate with 2.54 l H2 min-1 gcat-1 and good repeatability.	Hydrogen	164-166	NFS1 cysteine desulfurase	Homo sapiens	62-67
30406794-5	2018	The few graphitic carbon layer-encapsulated nanoparticles with the main W2C phase prepared by this simple method exhibit high efficiency for hydrogen generation with a low overpotential of 240 mV at a current density of 10 mA cm-2 and a low Tafel slope of 86 mV dec-1.	Hydrogen	141-149	deleted in esophageal cancer 1	Homo sapiens	262-267
28559343-9	2017	In the intramolecular oxidation of PDI, a transition state is only observed if hydrogen bond donors are nearby the mixed disulfide intermediate, which emphasizes that the thermochemistry of thiol-disulfide exchange in PDI is influenced by the presence of hydrogen bond donors.	Hydrogen	79-87	prolyl 4-hydroxylase subunit beta	Homo sapiens	35-38
28559343-9	2017	In the intramolecular oxidation of PDI, a transition state is only observed if hydrogen bond donors are nearby the mixed disulfide intermediate, which emphasizes that the thermochemistry of thiol-disulfide exchange in PDI is influenced by the presence of hydrogen bond donors.	Hydrogen	79-87	prolyl 4-hydroxylase subunit beta	Homo sapiens	218-221
28559343-9	2017	In the intramolecular oxidation of PDI, a transition state is only observed if hydrogen bond donors are nearby the mixed disulfide intermediate, which emphasizes that the thermochemistry of thiol-disulfide exchange in PDI is influenced by the presence of hydrogen bond donors.	Hydrogen	255-263	prolyl 4-hydroxylase subunit beta	Homo sapiens	35-38
28559343-9	2017	In the intramolecular oxidation of PDI, a transition state is only observed if hydrogen bond donors are nearby the mixed disulfide intermediate, which emphasizes that the thermochemistry of thiol-disulfide exchange in PDI is influenced by the presence of hydrogen bond donors.	Hydrogen	255-263	prolyl 4-hydroxylase subunit beta	Homo sapiens	218-221
27251953-0	2016	Biomolecule-assisted synthesis of defect-mediated Cd1-xZnxS/MoS2/graphene hollow spheres for highly efficient hydrogen evolution.	Hydrogen	110-118	CD1c molecule	Homo sapiens	50-53
27198730-2	2016	Computational analysis suggested that tin monosulfide (SnS) would be more efficient than SnS2 as a photocathode for hydrogen production because of the low ionization potential and weak ionic character of SnS.	Hydrogen	116-124	sodium voltage-gated channel alpha subunit 11	Homo sapiens	89-93
30526872-5	2018	By hydrogen bonding with multiple backbone carbonyls of the peptides, KLHDC2 further locks in the otherwise degenerate degrons with a compact interface and unexpected high affinities.	Hydrogen	3-11	kelch domain containing 2	Homo sapiens	70-76
26784277-12	2016	CD11b expression on CD14 CD16 was significantly greater at IP (P &lt; 0.014) and 1H (P = 0.009).	Hydrogen	81-83	CD14 molecule	Homo sapiens	20-24
27347307-6	2016	The enhanced HPSE next released HS-bonded latent TGF-beta from myofibroblast ECM by cleaving HS chains to promote the initiation and progression of BOS.	Hydrogen	32-34	transforming growth factor, beta 1	Mus musculus	49-57
28453785-9	2017	Hydrogen-deuterium exchange indicates protection of a surface on the PNKP phosphatase domain that may contact XRCC4-LigIV.	Hydrogen	0-8	X-ray repair cross complementing 4	Homo sapiens	110-115
30380511-8	2018	RESULTS: Therapy with 2% H2 increased PaO2/FiO2 ratios, MMP and ATP levels, RCR, complex I activity and MFN2 expression but decreased histological score and Drp1 levels in the presence of sepsis.	Hydrogen	25-27	mitofusin 2	Mus musculus	104-108
28195409-1	2017	Isolable dialkylsilylene 5 reacts with dihydrogen in the presence of a small amount of a conventional Lewis acid (BPh3 , BEt3 ) or a base (PPh3 , PEt3 , NPh3 , NEt3 ) at low temperatures in a hydrocarbon solvent, giving the corresponding dihydrosilane 10 in high yields.	Hydrogen	39-49	tetraspanin 2	Homo sapiens	160-164
26813142-1	2016	BACKGROUND: Hydrogen sulfide (H2 S) is endogenously generated from L-cysteine (L-Cys) by the enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-Lyase (CSE).	Hydrogen	30-32	cystathionine gamma-lyase	Rattus norvegicus	139-164
26813142-1	2016	BACKGROUND: Hydrogen sulfide (H2 S) is endogenously generated from L-cysteine (L-Cys) by the enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-Lyase (CSE).	Hydrogen	30-32	cystathionine gamma-lyase	Rattus norvegicus	166-169
30607149-4	2018	Based on the results, the compounds L1, L2, L4, L5, L6, L7, L10, L15, and L18 may be promising EGFR inhibitors based on docking score and hydrogen bonds.	Hydrogen	138-146	immunoglobulin kappa variable 1D-16	Homo sapiens	65-68
28425695-4	2017	Moreover, the enhanced mechanical properties including both the tensile strength and compressive strength of rGO/poly(AMPS-co-AAm) hydrogels are improved by the hydrogen-bond interactions between the rGO nanosheets and polymer chains, which could dissipate the strain energy in the polymeric networks of the hydrogels.	Hydrogen	161-169	adenylosuccinate lyase	Homo sapiens	118-122
30607149-8	2018	The results indicated that the three compounds bound to EGFR active site in a stable manner during the simulation through the formation of new hydrogen bonds with Phe699, Leu694, Gly700, Lys721, Met769, Arg817, and Asp831 with the superiority of compound L15.	Hydrogen	143-151	immunoglobulin kappa variable 1D-16	Homo sapiens	255-258
30354105-0	2018	NMR-Based Investigation of Hydrogen Bonding in a Dihydroanthracen-1(4 H)one from Rubia philippinensis and Its Soluble Epoxide Hydrolase Inhibitory Potential.	Hydrogen	27-35	epoxide hydrolase 2	Homo sapiens	110-135
28302724-2	2017	Significant positive-charge localization on one of the Chl constituents, PD1 or PD2, in P680+ has been proposed to contribute to this high Em To identify the Chl molecule on which the charge is mainly localized, we genetically introduced a hydrogen bond to the 131-keto C=O group of PD1 and PD2 by changing the nearby D1-Val-157 and D2-Val-156 residues to His, respectively.	Hydrogen	240-248	programmed cell death 1	Homo sapiens	73-76
28302724-2	2017	Significant positive-charge localization on one of the Chl constituents, PD1 or PD2, in P680+ has been proposed to contribute to this high Em To identify the Chl molecule on which the charge is mainly localized, we genetically introduced a hydrogen bond to the 131-keto C=O group of PD1 and PD2 by changing the nearby D1-Val-157 and D2-Val-156 residues to His, respectively.	Hydrogen	240-248	programmed cell death 1	Homo sapiens	283-286
29923387-0	2016	[Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury].	Hydrogen	12-20	aquaporin 1	Rattus norvegicus	53-64
29923387-12	2016	The mRNA and protein expressions of AQP1 in cerebral cortex were significantly decreased after hydrogen-rich water treatment [24-hour AQP1 mRNA (2-  Ct):5.40+-0.21 vs.7.50+-0.26, 24-hour AQP1 protein (gray value): 1.246+-0.137 vs.1.986+-0.110, both P &lt; 0.05].	Hydrogen	95-103	aquaporin 1	Rattus norvegicus	36-40
29923387-12	2016	The mRNA and protein expressions of AQP1 in cerebral cortex were significantly decreased after hydrogen-rich water treatment [24-hour AQP1 mRNA (2-  Ct):5.40+-0.21 vs.7.50+-0.26, 24-hour AQP1 protein (gray value): 1.246+-0.137 vs.1.986+-0.110, both P &lt; 0.05].	Hydrogen	95-103	aquaporin 1	Rattus norvegicus	134-138
29923387-12	2016	The mRNA and protein expressions of AQP1 in cerebral cortex were significantly decreased after hydrogen-rich water treatment [24-hour AQP1 mRNA (2-  Ct):5.40+-0.21 vs.7.50+-0.26, 24-hour AQP1 protein (gray value): 1.246+-0.137 vs.1.986+-0.110, both P &lt; 0.05].	Hydrogen	95-103	aquaporin 1	Rattus norvegicus	134-138
29923387-14	2016	Early treatment with an intraperitoneally injection of hydrogen-rich water is capable of attenuating the extent of TBI-induced up-regulation of AQP1 mRNA and protein, alleviating cerebral edema, and achieving its protective effects.	Hydrogen	55-63	aquaporin 1	Rattus norvegicus	144-148
28302724-3	2017	Successful hydrogen bond formation at PD1 and PD2 in the obtained D1-V157H and D2-V156H mutants, respectively, was monitored by detecting 131-keto C=O vibrations in Fourier transfer infrared (FTIR) difference spectra upon oxidation of P680 and the symmetrically located redox-active tyrosines YZ and YD, and they were simulated by quantum-chemical calculations.	Hydrogen	11-19	programmed cell death 1	Homo sapiens	38-41
30360101-4	2018	Ni-NiO/C HPPAs@NF shows a small overpotential of ~49.48 mV at the current density of 10 mA cm-2, low Tafel slope of 74 mV dec-1 and robust stability for hydrogen evolution reaction (HER) in alkaline media.	Hydrogen	153-161	deleted in esophageal cancer 1	Homo sapiens	122-127
28306549-1	2017	Variable temperature magic angle spinning (MAS) NMR measurements are reported on 1H and 31P nuclei in KH2PO4 (KDP) in the vicinity of its paraelectric-ferroelectric phase transition temperature, T c, of 123 K, to examine the transition mechanism, in particular if this is a model order-disorder type or whether it also involves a displacive component.	Hydrogen	81-83	WNK lysine deficient protein kinase 1	Homo sapiens	110-113
26991070-9	2016	In contrast to QTAIM, NCI analysis allowed for the identification of relatively weak intramolecular hydrogen bonding interactions between neighbouring oxo and hydroxido ligands in both [Os(VIII)O4(OH)](-) and cis-[Os(VIII)O4(OH)2](2-) complexes.	Hydrogen	100-108	cytochrome c oxidase subunit 8A	Homo sapiens	189-193
26991070-9	2016	In contrast to QTAIM, NCI analysis allowed for the identification of relatively weak intramolecular hydrogen bonding interactions between neighbouring oxo and hydroxido ligands in both [Os(VIII)O4(OH)](-) and cis-[Os(VIII)O4(OH)2](2-) complexes.	Hydrogen	100-108	cytochrome c oxidase subunit 8A	Homo sapiens	217-221
30229757-0	2018	Group-VIII transition metal boride as promising hydrogen evolution reaction catalysts.	Hydrogen	48-56	cytochrome c oxidase subunit 8A	Homo sapiens	6-10
26914368-3	2016	This newly prepared catalyst exhibited outstanding hydrogenolysis activity under 1 MPa H2 pressure with a very high space-time yield towards 1,3-propanediol (3.78 g gPt (-1)  h(-1) ) in Pt-W catalysts.	Hydrogen	87-89	glutamic--pyruvic transaminase	Homo sapiens	165-172
30441777-4	2018	The host-guest mechanism between PP5 and L-carnitine was studied by 1H NMR and molecular docking, indicating that more affinity binding force of CP5 with L-carnitine.	Hydrogen	68-70	protein phosphatase 5 catalytic subunit	Homo sapiens	33-36
26896627-10	2016	The NLRP3inh given 1h after reperfusion also significantly decreased caspase-1 activity and infarct size measured at 24h, whereas the NLRP3inh did not when given with a delay of 3h.	Hydrogen	19-21	caspase 1	Mus musculus	69-78
28406454-6	2017	The binding affinity of 3 for PKCdelta, which is involved in growth inhibition and apoptosis, was several times lower than those of 1 and 2, possibly due to the absence of the hydrogen bond and CH/pi interaction between its side chain and either Met-239 or Pro-241 in the PKCdelta-C1B domain.	Hydrogen	176-184	protein kinase C delta	Homo sapiens	30-38
30409010-0	2018	Rate coefficients of the H + H2O2   H2 + HO2 reaction on an accurate fundamental invariant-neural network potential energy surface.	Hydrogen	29-31	heme oxygenase 2	Homo sapiens	41-44
26973998-4	2016	Notably, an interlayer of dielectric silica (SiO2) between the GS-NSs and the ZIS photocatalyst provided another parameter to enhance the production of hydrogen and to distinguish the charge-transfer mechanisms.	Hydrogen	152-160	zinc finger RANBP2-type containing 2	Homo sapiens	78-81
30222362-10	2018	Poorly permeable compounds and MDR1 substrates were more likely to be large, flexible, and more capable of forming external hydrogen bonds.	Hydrogen	124-132	ATP binding cassette subfamily B member 1	Canis lupus familiaris	31-35
26973998-6	2016	Of the 10 particle samples examined in this study, the greatest hydrogen gas evolution rate was observed for GS-NSs having a SiO2 interlayer thickness of ~17 nm and an SPR absorption centered at ~700 nm, yielding a rate 2.6 times higher than that of the ZIS without GS-NSs.	Hydrogen	64-72	zinc finger RANBP2-type containing 2	Homo sapiens	254-257
26849428-6	2016	Restricted side-chain dynamics are observed for a number of polar residues including K13, D22, E27, K31, D36, N37, D46, D47, K50, and E56, which we attribute to the effects of salt bridges and hydrogen bonds.	Hydrogen	193-201	keratin 31	Homo sapiens	100-103
29883929-3	2018	The hydrogen production amount over EY-sensitized rGO/MOF/Ni4S3 photocatalyst has reached 280 mumol for 5 h, which is about 14 times than that of the pure Ni4S3 photocatalyst and 185 times than that of the pure rGO/MOF photocatalyst under visible light irradiation (lambda &gt;= 420 nm).	Hydrogen	4-12	lysine acetyltransferase 8	Homo sapiens	54-57
26808649-5	2016	Furthermore, simulations of hIAPP dimerization reveal that binding with the dendrimer significantly reduces formation of interpeptide contacts and hydrogen bonds, thereby prohibiting peptide self-association and amyloidosis.	Hydrogen	147-155	islet amyloid polypeptide	Homo sapiens	28-33
29883929-3	2018	The hydrogen production amount over EY-sensitized rGO/MOF/Ni4S3 photocatalyst has reached 280 mumol for 5 h, which is about 14 times than that of the pure Ni4S3 photocatalyst and 185 times than that of the pure rGO/MOF photocatalyst under visible light irradiation (lambda &gt;= 420 nm).	Hydrogen	4-12	lysine acetyltransferase 8	Homo sapiens	215-218
30280744-5	2018	It requires 202 mV to drive the hydrogen evolution reaction to reach 10 mA cm-2, while long-term durability and faster charge-transfer kinetics confirm the good hydrogen evolution reaction performance on FeS2/C/Ni foam.	Hydrogen	32-40	5'-nucleotidase, cytosolic IA	Homo sapiens	209-213
26879409-8	2016	The results clearly reveal the involvement of anion-pi bonding, as well as a weak, yet significant, hydrogen bonding interaction between the benzene C-H on 1 and the anion of NO3(-) or PF6(-).	Hydrogen	100-108	sperm associated antigen 17	Homo sapiens	185-188
26894942-5	2016	All three compounds demonstrate hydrogen bonds, as indicated by the intensities and half-widths of the bands in the vibrational spectra and by short N-H   F distances in the crystal structures of ZnF2(NH3)3 and ZnF2(NH3)2.	Hydrogen	32-40	zinc finger protein 2	Homo sapiens	196-200
30280744-5	2018	It requires 202 mV to drive the hydrogen evolution reaction to reach 10 mA cm-2, while long-term durability and faster charge-transfer kinetics confirm the good hydrogen evolution reaction performance on FeS2/C/Ni foam.	Hydrogen	161-169	5'-nucleotidase, cytosolic IA	Homo sapiens	209-213
26894942-5	2016	All three compounds demonstrate hydrogen bonds, as indicated by the intensities and half-widths of the bands in the vibrational spectra and by short N-H   F distances in the crystal structures of ZnF2(NH3)3 and ZnF2(NH3)2.	Hydrogen	32-40	zinc finger protein 2	Homo sapiens	211-215
30380790-1	2018	Recently, a project was initiated in Japan to transport a large amount of liquid hydrogen (LH2) from Australia to Japan by sea.	Hydrogen	81-89	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	91-94
30380790-4	2018	During this zigzag maneuver, the pressure of gaseous hydrogen (GH2) in the small LH2 tank increased to roughly 0.67 MPaG/h, and the temperature of the GH2 in the small LH2 tank increased at the position of gaseous hydrogen at roughly 1.0 K/min when the maximum rolling angle was 5 ; the average rolling and liquid-oscillation periods were 114 and 118 s, respectively, as detected by the MgB2 level sensors, which therefore detected a long-period LH2 wave due to the ship"s motion.	Hydrogen	53-61	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	81-84
26978186-5	2016	The results indicate that the superior performance largely depends on the higher lithium ion diffusion efficiency in PAN which results from the weak interaction between lithium ions and PAN polymer chain, and the hydrogen bonds among the nitrile group (C N) of PAN, Si nanoparticles, and the current collector, which will lead to an efficient coating of PAN with the Si particles and well-improved adhesion strength, synergistically depressing the structural deterioration of silicon electrodes.	Hydrogen	213-221	adenosine deaminase 2	Homo sapiens	117-120
30333031-1	2018	BACKGROUND: Sodium/hydrogen exchanger 1 (NHE1), encoded by the SLC9A1 gene (SoLute Carrier family 9A1) in humans, is the main H+ efflux mechanism in maintaining alkaline intracellular pH (pHi) and Warburg effects in glioma.	Hydrogen	19-27	glucose-6-phosphate isomerase	Homo sapiens	188-191
26875562-6	2016	Treatment with hydrogen reduced Ang II- or AAC-induced oxidative stress, which was reflected by diminishing the induction of reactive oxygen species (ROS) in Ang II-stimulated VSMCs, inhibiting the levels of 3-nitrotyrosine (3-NT) in vascular and serum malondialdehyde (MDA).	Hydrogen	15-23	angiogenin	Homo sapiens	32-35
30322084-4	2018	Furthermore, this paper describes an innovative membrane system (Membrane Gas-Liquid Contactor) for the extraction of hydrogen isotopes from liquid LiPb blankets.	Hydrogen	118-126	lipase B, lysosomal acid type	Homo sapiens	148-152
29917336-14	2016	Conclusion: Hydrogen-rich medium can effectively attenuate LPS-induced dysfunction of intestinal epithelial barrier in human Caco2 cells by ameliorating cell viability as well as regulating claudin-1 and occludin expression and structure.	Hydrogen	12-20	occludin	Homo sapiens	204-212
30322084-6	2018	Compared to the conventional hydrogen isotope extraction processes from LiPb that use the "permeator against vacuum" concept, the proposed process significantly reduces mass-transfer resistance by improving the efficiency of the tritium recovery system.	Hydrogen	29-37	lipase B, lysosomal acid type	Homo sapiens	72-76
30217558-4	2018	Using hydrogen/deuterium exchange mass spectrometry and physical mapping, we define minimal domains necessary for interaction between POLE3-POLE4 and histones H3-H4.	Hydrogen	6-14	DNA polymerase epsilon 3, accessory subunit	Homo sapiens	134-139
30850186-2	2018	As a kind of endo-beta-glucuronidase, heparanase is the known only enzyme in mammals which could degrade heparan sulfate(HS) specifically.	Hydrogen	121-123	glucuronidase beta	Homo sapiens	18-36
29858729-0	2018	1H, 15N, 13C backbone resonance assignment of human Alkbh5.	Hydrogen	0-2	alkB homolog 5, RNA demethylase	Homo sapiens	52-58
29858729-4	2018	Herein, we report the backbone 1H, 15N, 13C chemical shift assignment of a fully active, 26 kDa construct of human Alkbh5.	Hydrogen	31-33	alkB homolog 5, RNA demethylase	Homo sapiens	115-121
31950612-5	2018	In particular, the Co3 O4 /ZnO hybrid nanostructured electrode (60 s) exhibits the lowest onset potential of 1.5 V (vs. reversible hydrogen electrode, RHE).	Hydrogen	131-139	factor interacting with PAPOLA and CPSF1	Homo sapiens	151-154
30100327-12	2018	The expressions of superoxide dismutase (p = 0.022) and heme oxygenase-1 (p = 0.047) were significantly higher in the hydrogen group.	Hydrogen	118-126	heme oxygenase 1	Sus scrofa	56-72
30114912-5	2018	A diiron eta2-H2 intermediate in the formation of H2 is proposed, and is evidenced by the H/D exchange reactions of [1(mu-H)H]+ with D2, D2O, and CD3OD.	Hydrogen	14-16	DNA polymerase iota	Homo sapiens	9-13
30114912-5	2018	A diiron eta2-H2 intermediate in the formation of H2 is proposed, and is evidenced by the H/D exchange reactions of [1(mu-H)H]+ with D2, D2O, and CD3OD.	Hydrogen	50-52	DNA polymerase iota	Homo sapiens	9-13
30095844-1	2018	A high-performance dye-sensitized photocatalytic H2 evolution system was developed based on Forster resonance energy transfer (FRET) by employing water-soluble and highly photoluminescent N,S codoped graphene quantum dots (NSGQDs) as the homogeneous energy donor, erythrosin B (ErB) as the sensentizing dye, and platinum nanoparticles (Pt NPs) as the catalyst.	Hydrogen	49-51	estrogen receptor 2	Homo sapiens	264-276
30095844-1	2018	A high-performance dye-sensitized photocatalytic H2 evolution system was developed based on Forster resonance energy transfer (FRET) by employing water-soluble and highly photoluminescent N,S codoped graphene quantum dots (NSGQDs) as the homogeneous energy donor, erythrosin B (ErB) as the sensentizing dye, and platinum nanoparticles (Pt NPs) as the catalyst.	Hydrogen	49-51	estrogen receptor 2	Homo sapiens	278-281
30095844-2	2018	NSGQDs absorbed high-energy photons that undergo FRET to transfer the excitation energy to the sensitizing ErB for maximizing light absorption and also served as an electron transfer and loading matrix of Pt NPs for accelarating the electron transfer; as a result, the ErB-sensitized NSGQD-Pt system afforded much higher H2 evolution activity than the NSGQD-free dye-sensitized system.	Hydrogen	321-323	estrogen receptor 2	Homo sapiens	107-110
30542593-9	2018	Our results suggest that the rate limiting step for WT TET2 involves a hydrogen atom abstraction from the hydroxyl group of 5hmC by the ferryl moiety in the WT.	Hydrogen	71-79	tet methylcytosine dioxygenase 2	Homo sapiens	55-59
30022581-0	2018	Rational Design of MOF/COF Hybrid Materials for Photocatalytic H2 Evolution in the Presence of Sacrificial Electron Donors.	Hydrogen	63-65	lysine acetyltransferase 8	Homo sapiens	19-22
28529774-5	2017	In the crystal, the complex cations and the PF-6- anions are connected through weak N-H F, C-H F and C-H S hydrogen bonds into a three-dimensional structure.	Hydrogen	107-115	sperm associated antigen 17	Homo sapiens	44-48
30022581-5	2018	Especially, NH2 -UiO-66/TpPa-1-COF (4:6) exhibits the maximum photocatalytic H2 evolution rate of 23.41 mmol g-1  h-1 (with the TOF of 402.36 h-1 ), which is approximately 20 times higher than that of the parent TpPa-1-COF and the best performance photocatalyst for H2 evolution among various MOF- and COF-based photocatalysts.	Hydrogen	13-15	lysine acetyltransferase 8	Homo sapiens	293-296
30022581-5	2018	Especially, NH2 -UiO-66/TpPa-1-COF (4:6) exhibits the maximum photocatalytic H2 evolution rate of 23.41 mmol g-1  h-1 (with the TOF of 402.36 h-1 ), which is approximately 20 times higher than that of the parent TpPa-1-COF and the best performance photocatalyst for H2 evolution among various MOF- and COF-based photocatalysts.	Hydrogen	77-79	lysine acetyltransferase 8	Homo sapiens	293-296
30049206-4	2018	The hydrogen bonding between gelatin and BMP-2 on nHAp-BMP-2 enhanced the compatibility between inorganic and organic components.	Hydrogen	4-12	bone morphogenetic protein 2	Rattus norvegicus	41-46
28332657-0	2017	Enhanced hydrogen sorption in a Li-Mg-N-H system by the synergistic role of Li4(NH2)3BH4 and ZrFe2.	Hydrogen	9-17	lipase family member N	Homo sapiens	76-79
28332657-1	2017	The present investigation describes the synergistic role of Li4(BH4)(NH2)3 and ZrFe2 in the hydrogen storage behaviour of a Li-Mg-N-H hydride system.	Hydrogen	92-100	lipase family member N	Homo sapiens	60-63
28332657-3	2017	Native Mg(NH2)2-LiH-Li4(BH4)(NH2)3 absorbed only 2.78 wt% of H2 within 30 min.	Hydrogen	11-13	lipase family member N	Homo sapiens	20-23
28332657-4	2017	On the other hand, the ZrFe2-catalysed Mg(NH2)2-LiH-Li4(BH4)(NH2)3 sample absorbed 3.70 wt% of hydrogen within 30 min and 5 wt% of H2 in 6 h at 180  C and 7 MPa H2 pressure.	Hydrogen	95-103	lipase family member N	Homo sapiens	52-55
28332657-4	2017	On the other hand, the ZrFe2-catalysed Mg(NH2)2-LiH-Li4(BH4)(NH2)3 sample absorbed 3.70 wt% of hydrogen within 30 min and 5 wt% of H2 in 6 h at 180  C and 7 MPa H2 pressure.	Hydrogen	43-45	lipase family member N	Homo sapiens	52-55
30049206-4	2018	The hydrogen bonding between gelatin and BMP-2 on nHAp-BMP-2 enhanced the compatibility between inorganic and organic components.	Hydrogen	4-12	bone morphogenetic protein 2	Rattus norvegicus	55-60
28194820-4	2017	For the hydrogen evolution reaction (HER), the Ni-Mo2 C/C MF displays a low overpotential of 99 mV at a current density of -10 mA cm-2 and a small Tafel slope of 73 mV dec-1 in 1.0 m KOH.	Hydrogen	8-16	deleted in esophageal cancer 1	Homo sapiens	168-173
30030381-4	2018	Mutational studies disclosed that the hydroxyl group on the side chain of Tyr-245 in fungal viperin is the likely source of hydrogen in the last step of the radical addition, providing mechanistic insight into the radical reaction catalyzed by fungal viperin.	Hydrogen	124-132	radical S-adenosyl methionine domain containing 2	Homo sapiens	92-99
28740727-4	2017	The developed molecular model allowed us to uncover new Tdp1 inhibitors whose sulfo group is capable of occupying the position of the 3"-phosphate group of the substrate and forming hydrogen bonds with Lys265, Lys495, and other amino acid residues in the phosphotyrosine binding site.	Hydrogen	182-190	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	56-60
30030381-4	2018	Mutational studies disclosed that the hydroxyl group on the side chain of Tyr-245 in fungal viperin is the likely source of hydrogen in the last step of the radical addition, providing mechanistic insight into the radical reaction catalyzed by fungal viperin.	Hydrogen	124-132	radical S-adenosyl methionine domain containing 2	Homo sapiens	251-258
30271430-1	2018	A series of perimidine derivatives (L1-5) were prepared and characterized by IR, 1H NMR, mass spectroscopy, UV-Vis, XRD, thermal, and SEM analysis.	Hydrogen	81-83	immunoglobulin kappa variable 1D-16	Homo sapiens	36-40
27911498-3	2017	60 % after 12 h at -0.6 V vs. reversible hydrogen electrode, RHE], and its selectivity was tuned by the introduction of p-block elements (In, Sn, Ga, Al) into the catalyst.	Hydrogen	41-49	factor interacting with PAPOLA and CPSF1	Homo sapiens	61-64
30542572-3	2018	As compared to PBP and PNP pincer complexes, which are known to be good hydride and proton acceptors (respectively), complex 1 is found to be an effective hydrogen atom acceptor.	Hydrogen	155-163	dedicator of cytokinesis 3	Homo sapiens	15-18
31962031-0	2017	Co-SiO2 Nanocomposite Catalysts for COx -Free Hydrogen Production by Ammonia Decomposition.	Hydrogen	46-54	cytochrome c oxidase subunit 8A	Homo sapiens	36-39
29428499-8	2018	These differences mainly result from a combination of distinct electrostatic, van der Waals, hydrogen bonding and salt-bridge interactions between hIAPP and lipid bilayers.	Hydrogen	93-101	islet amyloid polypeptide	Homo sapiens	147-152
31962031-2	2017	These materials catalyze the decomposition of ammonia to produce COx -free hydrogen.	Hydrogen	75-83	cytochrome c oxidase subunit 8A	Homo sapiens	65-68
27859871-5	2017	The HAp crystals are organized into nano-rods oriented with c-axis preferentially parallel to the long axis of AS due to hydrogen bonds and electrostatic interaction and finally aggregated into HAp globule.	Hydrogen	121-129	reticulon 3	Homo sapiens	4-7
26914173-1	2016	Ammonia has high gravimetric and volumetric hydrogen densities and is, therefore, considered a promising carrier for the production of COx -free molecular H2 for forthcoming energy systems.	Hydrogen	155-157	cytochrome c oxidase subunit 8A	Homo sapiens	135-138
30154313-5	2018	Under conditions where the Pt deposition occurs and H2 evolution is occurring at the diffusion-limited rate (-0.3 V vs. NHE), Pt forms larger structures on the surface of HOPG, and the electrodeposition of Pt is not limited by diffusion.	Hydrogen	52-54	solute carrier family 9 member C1	Homo sapiens	120-123
26847163-8	2016	The piH-bonded water molecules are found to have faster translational dynamics and also found to follow a fast jump mechanism of reorientation to change their hydrogen bonded partners.	Hydrogen	159-167	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	4-7
28134630-4	2017	In this study, we examined the role of the polyamines in the regulation of connexin 43 (Cx43)-based gap junction channels under elevated intracellular concentrations of hydrogen ([H]i) and calcium ([Ca]i) ions.	Hydrogen	169-177	gap junction protein alpha 1	Homo sapiens	75-86
28134630-4	2017	In this study, we examined the role of the polyamines in the regulation of connexin 43 (Cx43)-based gap junction channels under elevated intracellular concentrations of hydrogen ([H]i) and calcium ([Ca]i) ions.	Hydrogen	169-177	gap junction protein alpha 1	Homo sapiens	88-92
30104375-8	2018	In addition, structural dynamics of Fzd4 associated with Norrin binding investigated by hydrogen/deuterium exchange MS revealed Norrin-induced conformational changes on the linker domain and the intracellular loop 3 (ICL3) region of Fzd4.	Hydrogen	88-96	frizzled class receptor 4	Homo sapiens	36-40
27986851-6	2017	Using hydrogen-deuterium eXchange coupled to mass spectrometry, we obtained experimental evidences that the Trm11-Trm112 interaction relies on the same molecular bases as those described for other Trm112-methyltransferases complexes.	Hydrogen	6-14	tRNA methyltransferase 11 homolog	Homo sapiens	108-113
26815033-6	2016	In addition, U18666a interacts with FAD by newly forming three hydrogen bonds with Lys292, Lys367, and Gly438 of DHCR24.	Hydrogen	63-71	24-dehydrocholesterol reductase	Homo sapiens	113-119
30104375-8	2018	In addition, structural dynamics of Fzd4 associated with Norrin binding investigated by hydrogen/deuterium exchange MS revealed Norrin-induced conformational changes on the linker domain and the intracellular loop 3 (ICL3) region of Fzd4.	Hydrogen	88-96	norrin cystine knot growth factor NDP	Homo sapiens	57-63
26732688-3	2016	H2 binding energies were calculated using the LMP2, DFT and DFT-D3 approaches with several exchange-correlation functionals and the results indicate a physisorption mechanism.	Hydrogen	0-2	proteasome 20S subunit beta 9	Homo sapiens	46-50
30104375-8	2018	In addition, structural dynamics of Fzd4 associated with Norrin binding investigated by hydrogen/deuterium exchange MS revealed Norrin-induced conformational changes on the linker domain and the intracellular loop 3 (ICL3) region of Fzd4.	Hydrogen	88-96	norrin cystine knot growth factor NDP	Homo sapiens	128-134
28055196-5	2017	Optimization of compound AQ-390/10779040 (IC50 = 4.6 muM) from the virtual screening, which holds a novel scaffold of benzo[cd]indol-2(1H)-one among PDE inhibitors, leads to discovery of a new compound LHB-8 with a significant improvement of inhibition (IC50 = 570 nM).	Hydrogen	135-137	phosphodiesterase 2A	Homo sapiens	149-152
30104375-8	2018	In addition, structural dynamics of Fzd4 associated with Norrin binding investigated by hydrogen/deuterium exchange MS revealed Norrin-induced conformational changes on the linker domain and the intracellular loop 3 (ICL3) region of Fzd4.	Hydrogen	88-96	frizzled class receptor 4	Homo sapiens	233-237
29803791-4	2018	The formation of HP-beta-CD/MLT inclusion complex was confirmed by 1H and 13C nuclear magnetic resonance spectroscopy and wide-angle X-ray diffraction.	Hydrogen	67-69	beta-carotene oxygenase 1	Mus musculus	20-27
27619973-8	2017	The substitution of Ca2+ by Cr3+ also greatly affected the vibration of the hydrogens associate to water, ranged from 3500 to 2600cm-1 in FTIR.	Hydrogen	76-85	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	28-31
26909920-10	2016	The damage to pulmonary epithelial cells improved after hydrogen treatment in rats with sepsis; hydrogen could protect the pulmonary epithelial barrier function by acting on AQP-1.	Hydrogen	56-64	aquaporin 1	Rattus norvegicus	174-179
26909920-10	2016	The damage to pulmonary epithelial cells improved after hydrogen treatment in rats with sepsis; hydrogen could protect the pulmonary epithelial barrier function by acting on AQP-1.	Hydrogen	96-104	aquaporin 1	Rattus norvegicus	174-179
26621199-2	2016	The synthesized MOF exhibits BET surface areas of 574 m(2) g(-1), showing the highest H2 adsorption capacity (1.05 wt% at 77 K, 1 bar) and the highest CO2 uptake (51 cm(3) g(-1) at 273 K, 1 bar) for currently known salen-based MOFs.	Hydrogen	86-88	lysine acetyltransferase 8	Homo sapiens	16-19
29920974-3	2018	Herein, we report a new photoreformation of cellulose into H2 over TiO2 that is modified with nickel sulfide (Nix Sy ) and chemisorbed sulfate species (SO42- ) by a one-pot approach.	Hydrogen	59-61	BCL2 interacting protein 3 like	Homo sapiens	110-113
26695379-3	2016	The as-synthesized nanohybrids exhibited high catalytic ability for the hydrogen evolution electrochemical reaction with an onset overpotential of 0.165 mV and a Tafel slope of 46 mV dec(-1).	Hydrogen	72-80	deleted in esophageal cancer 1	Homo sapiens	183-189
27266724-2	2017	The generation of H2 gas in PRBs, however, can decrease the permeability of PRBs and reduce the contact area between the PRB and contaminated groundwater.	Hydrogen	18-20	RB transcriptional corepressor 1	Homo sapiens	28-31
27727489-6	2017	In addition, the intermolecular hydrogen bond network that kept the AM stable in the binding site of KLHL3 was disrupted, and the forces for the hydrophobic interactions between the AM of WNK4 and KLHL3 were also reduced.	Hydrogen	32-40	kelch like family member 3	Homo sapiens	101-106
29920974-6	2018	Specifically, Nix Sy acts as a cocatalyst for photocatalytic H2 production, and we infer that SO42- ions promote cellulose hydrolysis and the consequent accessibility of the biomass to catalysts.	Hydrogen	61-63	BCL2 interacting protein 3 like	Homo sapiens	14-17
26790958-9	2016	Conversely, overexpression of PMA1 conferred sensitivity to IILs, suggesting that hydrogen ion efflux may be coupled to influx of the toxic imidazolium cation.	Hydrogen	82-90	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	30-34
29920974-8	2018	Overall, our strategy for the modification of TiO2 with SO42- and Nix Sy provides a new perspective for the concurrent acceleration of cellulose hydrolysis and increase of the number of hydrogen evolution sites for the efficient photocatalytic reformation of cellulose into H2 .	Hydrogen	186-194	BCL2 interacting protein 3 like	Homo sapiens	66-69
29920974-8	2018	Overall, our strategy for the modification of TiO2 with SO42- and Nix Sy provides a new perspective for the concurrent acceleration of cellulose hydrolysis and increase of the number of hydrogen evolution sites for the efficient photocatalytic reformation of cellulose into H2 .	Hydrogen	274-276	BCL2 interacting protein 3 like	Homo sapiens	66-69
27727489-6	2017	In addition, the intermolecular hydrogen bond network that kept the AM stable in the binding site of KLHL3 was disrupted, and the forces for the hydrophobic interactions between the AM of WNK4 and KLHL3 were also reduced.	Hydrogen	32-40	kelch like family member 3	Homo sapiens	197-202
30098248-9	2018	Analysis using Pymol indicated that the number of hydrogen bonds has changed, which led to a transformation of the structure of the FXI protein.	Hydrogen	50-58	coagulation factor XI	Homo sapiens	132-135
27727489-8	2017	In conclusion, phosphorylation of KLHL3 at S433 disrupts the hydrogen bonds, hydrophobic and electrostatic interactions between the Kelch domain of KLHL3 and the AM of WNK4.	Hydrogen	61-69	kelch like family member 3	Homo sapiens	34-39
27727489-8	2017	In conclusion, phosphorylation of KLHL3 at S433 disrupts the hydrogen bonds, hydrophobic and electrostatic interactions between the Kelch domain of KLHL3 and the AM of WNK4.	Hydrogen	61-69	kelch like family member 3	Homo sapiens	148-153
26658549-3	2016	In this work, we present calculations including all paths for two prototype combustion reactions, namely the two hydrogen abstraction reactions from tert-butanol by HO2 radical.	Hydrogen	113-121	heme oxygenase 2	Homo sapiens	165-168
26985314-2	2016	The cocrystal structure of 18 bound to the active site indicated two hydrogen-bond interactions between the dimethylisoxazole and threonine 72 and glutamine 73 of the flap.	Hydrogen	69-77	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	167-171
29852353-0	2018	Hydrogen gas inhibits lung cancer progression through targeting SMC3.	Hydrogen	0-8	structural maintenance of chromosomes 3	Homo sapiens	64-68
27342272-9	2017	RESULTS: The results showed that both profiles of high-dose H2 breathing reduced the size of the endometrial explants, inhibited cell proliferation, improved superoxide dismutase, glutathione peroxidase, malondialdehyde, and catalase activities, and regulated the expression of matrix metalloproteinase 9 and cyclooxygenase 2.	Hydrogen	60-62	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	309-325
29852353-8	2018	Besides, H2 down-regulated the expression of NIBPL, SMC3, SMC5 and SMC6, and also reduced the expression of Cyclin D1, CDK4 and CDK6.	Hydrogen	9-11	structural maintenance of chromosomes 3	Homo sapiens	52-56
29852353-8	2018	Besides, H2 down-regulated the expression of NIBPL, SMC3, SMC5 and SMC6, and also reduced the expression of Cyclin D1, CDK4 and CDK6.	Hydrogen	9-11	structural maintenance of chromosomes 5	Homo sapiens	58-62
26542736-0	2016	Guanine nucleotide induced conformational change of Cdc42 revealed by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	70-78	cell division cycle 42	Homo sapiens	52-57
29852353-8	2018	Besides, H2 down-regulated the expression of NIBPL, SMC3, SMC5 and SMC6, and also reduced the expression of Cyclin D1, CDK4 and CDK6.	Hydrogen	9-11	cyclin D1	Homo sapiens	108-117
27918646-6	2017	In acidic media, the CBC/MoSe2 hybrid catalyst exhibits fast hydrogen evolution kinetics with onset overpotential of 91 mV and Tafel slope of 55 mV dec-1 , which is much more outstanding than both bulk MoSe2 aggregates and CBC nanofibers.	Hydrogen	61-69	deleted in esophageal cancer 1	Homo sapiens	148-153
29852353-8	2018	Besides, H2 down-regulated the expression of NIBPL, SMC3, SMC5 and SMC6, and also reduced the expression of Cyclin D1, CDK4 and CDK6.	Hydrogen	9-11	cyclin dependent kinase 4	Homo sapiens	119-123
29852353-9	2018	H2 translocated the subcellular location of SMC3 during cell division and decreased its stability and increased its ubiquitination in both A549 and H1975 cells.	Hydrogen	0-2	structural maintenance of chromosomes 3	Homo sapiens	44-48
29852353-10	2018	In addition, inhibition of the proliferation, migration and invasion and promotion of the apoptosis of A549 and H1975 cells induced by H2 were all abolished when overexpressed SMC3 in the presence of H2.	Hydrogen	135-137	structural maintenance of chromosomes 3	Homo sapiens	176-180
26889236-5	2016	The results showed that hydrogen-rich saline significantly decreased the levels of VEGF, TM and LPO and increased the GSH level in steroid-associated necrosis of the femoral head in the rabbit model.	Hydrogen	24-32	thrombomodulin	Oryctolagus cuniculus	89-91
29852353-10	2018	In addition, inhibition of the proliferation, migration and invasion and promotion of the apoptosis of A549 and H1975 cells induced by H2 were all abolished when overexpressed SMC3 in the presence of H2.	Hydrogen	200-202	structural maintenance of chromosomes 3	Homo sapiens	176-180
28085263-7	2017	Such in-depth structural study of Htt presents a number of unique challenges: the long homopolymeric polyQ tract contains nearly identical residues, exon 1 displays a high degree of conformational flexibility leading to a scaling of the NMR chemical shift dispersion, and a large portion of the backbone amide groups are solvent-exposed leading to fast hydrogen exchange and causing extensive line broadening.	Hydrogen	353-361	huntingtin	Homo sapiens	34-37
28768463-5	2018	Our results indicated that PcTx1can mainly regulate ASIC1a gating process through hydrogen bonds, which can affect their relative positions of several key domains in ASIC1a, further, a long-range conformational changes path was determined, which is composed of beta1, beta2, beta10, alpha6, alpha7, beta11, and beta12 in ASIC1a.	Hydrogen	82-90	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	268-273
27936804-1	2017	With first-principles calculations, we find a new strategy for developing high-performance catalysts for hydrogen evolution reaction (HER) via controlling the morphology and size of nanopolygons of monolayer transition-metal dichalcogenides (npm-MS2, with M = Mo, W, or V).	Hydrogen	105-113	nucleophosmin 1	Homo sapiens	242-245
26649316-7	2016	Peptide-lipid interaction analyses show that the different binding features of hIAPP at POPC and POPG bilayers are attributed to different magnitudes of electrostatic and hydrogen-bonding interactions with lipids.	Hydrogen	171-179	islet amyloid polypeptide	Homo sapiens	79-84
26916499-7	2016	Additionally, the presence of a group that is capable of performing hydrogen bonding interactions as either a donor or acceptor in the 4" position is important for the interaction with the Glu-268 residue; this group is the primary pharmacophore that should be attached to the scaffold of the aromatic nucleus of an ideal inhibitor of ALDH-2.	Hydrogen	68-76	aldehyde dehydrogenase 2 family member	Homo sapiens	335-341
26642107-7	2015	High current efficiency (83-99%) confirmed absence of any side reaction and 328.05 kJ mol-H2(-1) energy was required for to produce 1 mol of H2 by electrolytic cell with SCP-1.33 membrane.	Hydrogen	90-92	synaptonemal complex protein 1	Homo sapiens	170-175
29764757-0	2018	Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition.	Hydrogen	142-144	TTK protein kinase	Homo sapiens	184-188
26319330-0	2015	Pt-decorated GaN nanowires with significant improvement in H2 gas-sensing performance at room temperature.	Hydrogen	59-61	gigaxonin	Homo sapiens	13-16
27491936-10	2017	Docking simulation has also been performed to analyze the binding mode of compounds and the results showed that compound 2, the most active compound, formed a hydrogen bond with Glu202 for binding to the MMP-2 active site.	Hydrogen	159-167	matrix metallopeptidase 2	Homo sapiens	204-209
26319330-1	2015	Superior sensitivity towards H2 gas was successfully achieved with Pt-decorated GaN nanowires (NWs) gas sensor.	Hydrogen	29-31	gigaxonin	Homo sapiens	80-83
29870234-3	2018	Among them, the 1T"-phase ReSSe nanodot exhibits the highest hydrogen evolution activity, with a Tafel slope of 50.1 mV dec-1 and a low overpotential of 84 mV at current density of 10 mA cm-2.	Hydrogen	61-69	deleted in esophageal cancer 1	Homo sapiens	120-125
26319330-4	2015	The Pt-decorated GaN NWs sensor shows a high response of 250-2650% upon exposure to H2 gas concentration from 7 to 1000ppm respectively at room temperature (RT), and then increases to about 650-4100% when increasing the operating temperature up to 75 C. The gas-sensing measurements indicated that the Pt-decorated GaN NWs based sensor exhibited efficient detection of H2 at low concentration with excellent sensitivity, repeatability, and free hysteresis phenomena over a period of time of 100min.	Hydrogen	84-86	gigaxonin	Homo sapiens	17-20
26319330-4	2015	The Pt-decorated GaN NWs sensor shows a high response of 250-2650% upon exposure to H2 gas concentration from 7 to 1000ppm respectively at room temperature (RT), and then increases to about 650-4100% when increasing the operating temperature up to 75 C. The gas-sensing measurements indicated that the Pt-decorated GaN NWs based sensor exhibited efficient detection of H2 at low concentration with excellent sensitivity, repeatability, and free hysteresis phenomena over a period of time of 100min.	Hydrogen	369-371	gigaxonin	Homo sapiens	17-20
26319330-5	2015	The large surface-to-volume ratio of GaN NWs and the catalytic activity of Pt metal are the most influential factors leading to the enhancement of H2 gas-sensing performances through the improvement of the interaction between the target molecules (H2) and the sensing NWs surface.	Hydrogen	147-149	gigaxonin	Homo sapiens	37-40
26319330-5	2015	The large surface-to-volume ratio of GaN NWs and the catalytic activity of Pt metal are the most influential factors leading to the enhancement of H2 gas-sensing performances through the improvement of the interaction between the target molecules (H2) and the sensing NWs surface.	Hydrogen	248-250	gigaxonin	Homo sapiens	37-40
26319330-6	2015	The attractive low-cost, low power consumption and high-performance of the resultant decorated GaN NWs gas sensor assure their uppermost potential for H2 gas sensor working at low operating temperature.	Hydrogen	151-153	gigaxonin	Homo sapiens	95-98
28451182-8	2017	It is expected that the proton shuttle mechanisms unravelled for hGBP1 apply to many classes of GTPases/ATPases that possess an optimally-arranged hydrogen bonding network, which connects the catalytic water to a proton acceptor.	Hydrogen	147-155	guanylate binding protein 1	Homo sapiens	65-70
30147990-4	2018	The lowest-energy transition states (TSs) from density functional theory computational analyses have N-H   O hydrogen-bonding interactions between PhN(H)Beg and O atoms in Beg ligands.	Hydrogen	109-117	carbamoyl-phosphate synthase 1	Homo sapiens	147-150
27757847-7	2017	Intriguingly, the side chain of LC3B Lys49 shifts remarkably and forms a hydrogen bond and electrostatic interaction with the phosphate group of FUNDC1 pS17.	Hydrogen	73-81	microtubule associated protein 1 light chain 3 beta	Homo sapiens	32-36
27757847-7	2017	Intriguingly, the side chain of LC3B Lys49 shifts remarkably and forms a hydrogen bond and electrostatic interaction with the phosphate group of FUNDC1 pS17.	Hydrogen	73-81	FUN14 domain containing 1	Homo sapiens	145-151
26707983-8	2016	An increase of BOD5/COD ratio from 0.012 to 0.44 was obtained after 1h EF treatment, along with 47% TOC removal and a significant decrease of toxicity, demonstrating the feasibility of a post-biological treatment.	Hydrogen	68-70	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	20-23
26474790-5	2015	Our results demonstrate that ESP ensembles, though much smaller in size comparing to regular ensembles, perform equally or even better sometimes in all four different types of experimental data used in the assessment, namely, the residual dipolar couplings, residual chemical shift anisotropy, hydrogen exchange rates, and solution scattering profiles.	Hydrogen	294-302	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	29-32
26492815-8	2015	In sum, our results suggest that activity of GalE-like TDH can be regulated by remote interaction, such as hydrogen bonding and hydrophobic interaction around the Arg180 of mTDH.	Hydrogen	107-115	L-threonine dehydrogenase	Mus musculus	55-58
30147990-6	2018	1H NMR experiments show that N-borylation fully generates PhN(Me)Beg prior to CHB.	Hydrogen	0-2	carbamoyl-phosphate synthase 1	Homo sapiens	58-61
26497733-0	2015	Enhance photoelectrochemical hydrogen-generation activity and stability of TiO2 nanorod arrays sensitized by PbS and CdS quantum dots under UV-visible light.	Hydrogen	29-37	cholinergic receptor muscarinic 3	Homo sapiens	109-112
29971960-5	2018	By virtue of the favorable hydrogen adsorption energies on Ni0 and OHads energy on NiO or NiOOH, the 3D electrode exhibits high performance in hydrogen evolution reaction with 146 mV at eta10 mA cm-2 and Tafel value of 72 mV dec-1 , and oxygen evolution reaction with 382 mV at eta10 mA cm-2 and Tafel value of 103 mV dec-1 in 1 m KOH.	Hydrogen	27-35	deleted in esophageal cancer 1	Homo sapiens	225-230
26436856-1	2015	Interactions of hydrogen sulfide (HS(-)/H2S), a reducing signaling species, with superoxide dimutases (SOD) are poorly understood.	Hydrogen	34-36	superoxide dismutase 2	Homo sapiens	103-106
27573935-0	2016	Application of amide hydrogen/deuterium exchange mass spectrometry for epitope mapping in human cystatin C.	Hydrogen	21-29	cystatin C	Homo sapiens	96-106
27841335-0	2016	Hydrogen-bond potential for ice VIII-X phase transition.	Hydrogen	0-8	cytochrome c oxidase subunit 8A	Homo sapiens	32-36
29971960-5	2018	By virtue of the favorable hydrogen adsorption energies on Ni0 and OHads energy on NiO or NiOOH, the 3D electrode exhibits high performance in hydrogen evolution reaction with 146 mV at eta10 mA cm-2 and Tafel value of 72 mV dec-1 , and oxygen evolution reaction with 382 mV at eta10 mA cm-2 and Tafel value of 103 mV dec-1 in 1 m KOH.	Hydrogen	27-35	deleted in esophageal cancer 1	Homo sapiens	318-323
29971960-5	2018	By virtue of the favorable hydrogen adsorption energies on Ni0 and OHads energy on NiO or NiOOH, the 3D electrode exhibits high performance in hydrogen evolution reaction with 146 mV at eta10 mA cm-2 and Tafel value of 72 mV dec-1 , and oxygen evolution reaction with 382 mV at eta10 mA cm-2 and Tafel value of 103 mV dec-1 in 1 m KOH.	Hydrogen	143-151	deleted in esophageal cancer 1	Homo sapiens	225-230
26449991-2	2015	467-MOF exhibits superior thermal and chemical stability and, moreover, shows high CO2 sorption selectivity over H2 , with a selectivity, based on the ideal adsorbed solution theory (IAST) of approximately 45 at 273 or 293 K. Furthermore, its solvent-dependent photoluminescence makes it an applicable sensor in the detection of nitrobenzene explosives through fluorescence quenching.	Hydrogen	113-115	lysine acetyltransferase 8	Homo sapiens	4-7
29971960-5	2018	By virtue of the favorable hydrogen adsorption energies on Ni0 and OHads energy on NiO or NiOOH, the 3D electrode exhibits high performance in hydrogen evolution reaction with 146 mV at eta10 mA cm-2 and Tafel value of 72 mV dec-1 , and oxygen evolution reaction with 382 mV at eta10 mA cm-2 and Tafel value of 103 mV dec-1 in 1 m KOH.	Hydrogen	143-151	deleted in esophageal cancer 1	Homo sapiens	318-323
30424240-9	2018	Interestingly, the deposition of single mucin layers (mucin/water)3 has also been proven, however, the capsules were unstable, most probably due to additional (to hydrogen bonding) electrostatic interactions in the case of the two polymers used.	Hydrogen	163-171	LOC100508689	Homo sapiens	40-45
26509703-6	2015	In spite of these similarities, they catalyze very different reactions: Nap abstracts an oxygen atom from nitrate releasing nitrite, whereas FdH catalyzes a hydrogen atom transfer from formate and releases carbon dioxide.	Hydrogen	157-165	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	141-144
27605664-1	2016	Bovine heart cytochrome c oxidase (CcO) pumps four proton equivalents per catalytic cycle through the H-pathway, a proton-conducting pathway, which includes a hydrogen bond network and a water channel operating in tandem.	Hydrogen	159-167	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	13-33
27605664-1	2016	Bovine heart cytochrome c oxidase (CcO) pumps four proton equivalents per catalytic cycle through the H-pathway, a proton-conducting pathway, which includes a hydrogen bond network and a water channel operating in tandem.	Hydrogen	159-167	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	35-38
30424240-9	2018	Interestingly, the deposition of single mucin layers (mucin/water)3 has also been proven, however, the capsules were unstable, most probably due to additional (to hydrogen bonding) electrostatic interactions in the case of the two polymers used.	Hydrogen	163-171	LOC100508689	Homo sapiens	54-59
29868660-0	2018	Size structure-catalytic performance correlation of supported Ni/MCF-17 catalysts for COx-free hydrogen production.	Hydrogen	95-103	cytochrome c oxidase subunit 8A	Homo sapiens	86-89
27693566-6	2016	To analyze the effect of P188 on autophagy, the LC3 protein levels were assessed by western blotting 1h, 6h, 12h, 24h, and 48h after TBI.	Hydrogen	101-103	annexin A3	Rattus norvegicus	48-51
26463124-1	2015	The alkali metal amidozincates Li4 [Zn(NH2)4](NH2)2 and K2[Zn(NH2)4] were, to the best of our knowledge, studied for the first time as hydrogen storage media.	Hydrogen	135-143	lipase family member N	Homo sapiens	31-34
26397063-6	2015	The results showed that PPARgamma, as a target of miR-27b, played a significant role in suppressing cervical cancer progression by downregulating the sodium-hydrogen exchanger isoform 1 (NHE1).	Hydrogen	157-165	microRNA 27b	Homo sapiens	50-57
27808173-0	2016	Metabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A 1H NMR-based metabolomics investigation.	Hydrogen	95-97	fibroblast growth factor 2	Rattus norvegicus	21-51
29868660-1	2018	Herein, supported Ni/MCF-17 catalysts with the size of nickel nanocrystal in the range of 1.5-8.0 nm were synthesized and employed for COx-free hydrogen production for fuel cells via the ammonia decomposition reaction.	Hydrogen	144-152	cytochrome c oxidase subunit 8A	Homo sapiens	135-138
26412242-1	2015	We demonstrate the redox potential calculation relative to the normal hydrogen electrode (NHE) in nonaqueous solution using a density functional theory-based molecular dynamics (DFT-MD) simulation.	Hydrogen	70-78	solute carrier family 9 member C1	Homo sapiens	90-93
29868660-4	2018	It was later revealed that Ni nanoparticles with different particle sizes exhibited significant differences in catalyzing the COx-free hydrogen production reaction.	Hydrogen	135-143	cytochrome c oxidase subunit 8A	Homo sapiens	126-129
29845997-3	2018	Abundant hydrogen-bonding and pi-pi interactions in the MOF facilitate electron transfer from ligand-to-metal, resulting in a good luminescence peak at 412 nm and an efficient fluorescence quenching of MOF 1 in the presence of Cu2+ ions, due to the inner filter effect.	Hydrogen	9-17	lysine acetyltransferase 8	Homo sapiens	56-59
26490223-6	2015	Three stable and metallic species with stoichiometries of HSe2, HSe and H3Se are identified above ~120 GPa and they all exhibit superconductive behaviors, of which the hydrogen-rich HSe and H3Se phases show high Tc in the range of 40-110 K. Our simulations established the high-temperature superconductive nature of selenium hydrides and provided useful route for experimental verification.	Hydrogen	168-176	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	58-61
26490223-6	2015	Three stable and metallic species with stoichiometries of HSe2, HSe and H3Se are identified above ~120 GPa and they all exhibit superconductive behaviors, of which the hydrogen-rich HSe and H3Se phases show high Tc in the range of 40-110 K. Our simulations established the high-temperature superconductive nature of selenium hydrides and provided useful route for experimental verification.	Hydrogen	168-176	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	64-67
29845997-3	2018	Abundant hydrogen-bonding and pi-pi interactions in the MOF facilitate electron transfer from ligand-to-metal, resulting in a good luminescence peak at 412 nm and an efficient fluorescence quenching of MOF 1 in the presence of Cu2+ ions, due to the inner filter effect.	Hydrogen	9-17	lysine acetyltransferase 8	Homo sapiens	202-205
29782672-0	2018	High-Yield Production of Monolayer FePS3 Quantum Sheets via Chemical Exfoliation for Efficient Photocatalytic Hydrogen Evolution.	Hydrogen	110-118	sodium voltage-gated channel alpha subunit 11	Homo sapiens	35-40
26103094-8	2015	Surprisingly, the activation of AMP-activated protein kinase (AMPK) was considerably increased by pretreatment with CTRP3 for 1h.	Hydrogen	126-128	C1q and tumor necrosis factor related protein 3	Mus musculus	116-121
29806525-1	2018	Atom-based three dimensional-quantitative structure-activity relationship (3D-QSAR) model was developed on the basis of 5-point pharmacophore hypothesis (AARRR) with two hydrogen bond acceptors (A) and three aromatic rings for the derivatives of thieno[2,3-b]pyridine, which modulates the activity to inhibit the mGluR5 receptor.	Hydrogen	170-178	glutamate receptor, ionotropic, kainate 1	Mus musculus	313-319
26113037-6	2015	These results suggest that exogenous H2 S recovers PC-induced cardioprotection via MAPK pathway in the aged hearts.	Hydrogen	37-39	mitogen activated protein kinase 3	Rattus norvegicus	83-87
29505789-5	2018	Notably, the consequence of TLR3 activation on neuronal function was reproduced in iPSC-derived cortical neurons, with poly I:C (25 mug/ml, 1h) significantly inhibiting sAP firing.	Hydrogen	140-142	toll like receptor 3	Homo sapiens	28-32
26435764-0	2015	Exsolution of Fe and SrO Nanorods and Nanoparticles from Lanthanum Strontium Ferrite La0.6Sr0.4FeO3-delta Materials by Hydrogen Reduction.	Hydrogen	119-127	stomatin like 3	Homo sapiens	21-24
26435764-7	2015	In contrast, formation of SrO rods following reduction in dry hydrogen is a catalytic process aided by Ni particles.	Hydrogen	62-70	stomatin like 3	Homo sapiens	26-29
29716191-5	2018	The pH- and light-induced self-assembly behaviors of SPB-functionalized Au NPs in the absence and presence of DIN, respectively, were systematically studied by various techniques including UV-vis spectrum, transmission electron microscope, nuclear magnetic resonance, and Fourier transform infrared spectroscopy, which evidently confirmed that the stimuli-responsive self-assembly was controlled by the hydrogen-bonding interactions between phenylboronic acid moieties.	Hydrogen	403-411	surfactant protein B	Homo sapiens	53-56
29672051-1	2018	The medically important drug target galectin-3 binds galactose-containing moieties on glycoproteins through an intricate pattern of hydrogen bonds to a largely polar surface-exposed binding site.	Hydrogen	132-140	galectin 3	Homo sapiens	36-46
26188301-5	2015	BW30 films deserved lower roughness rates than BW20 (and even BW10) films, indicating more advantageous microstructure and higher hydrogen connections in BW30 films and justifying similar melting points attained for BW30 films to BW20 or 10 ones.	Hydrogen	130-138	BW30	Homo sapiens	0-4
26065652-4	2015	Hydrogen-deuterium exchange mass spectrometry corroborated the importance of the C1 domain in D"D3 binding and implicates additional surface regions on FVIII in the interaction.	Hydrogen	0-8	coagulation factor VIII	Homo sapiens	152-157
29455102-2	2018	The synergistic effect of g-C3N4/SrTiO3 (CN/STO) heterojunction and NiS cocatalyst enhanced the photocatalytic hydrogen evolution activity of NS/CN/STO.	Hydrogen	111-119	nuclear receptor binding SET domain protein 1	Homo sapiens	44-47
26196342-0	2015	Hydrogen/Deuterium Exchange and Molecular Dynamics Analysis of Amyloid Fibrils Formed by a D69K Charge-Pair Mutant of Human Apolipoprotein C-II.	Hydrogen	0-8	apolipoprotein C2	Homo sapiens	124-143
29455102-2	2018	The synergistic effect of g-C3N4/SrTiO3 (CN/STO) heterojunction and NiS cocatalyst enhanced the photocatalytic hydrogen evolution activity of NS/CN/STO.	Hydrogen	111-119	nuclear receptor binding SET domain protein 1	Homo sapiens	142-151
29455102-5	2018	The heterojunction and cocatalyst in NS/CN/STO improved the charge separation efficiency and the lifetime of the charge carriers, leading to the enhanced generation of electrons for photocatalytic hydrogen production.	Hydrogen	197-205	nuclear receptor binding SET domain protein 1	Homo sapiens	37-46
25967263-6	2015	We found that intra-VTA microinjection of 1, 2, and 4mug of ghrelin, induced a dose-related increase of 1h of reward-based feeding on HFD in sated rats, as well as a 24-h body weight gain.	Hydrogen	104-106	ghrelin and obestatin prepropeptide	Rattus norvegicus	60-67
29723265-3	2018	We here report a novel CLK inhibitor family based on a 6,7-dihydropyrrolo[3,4-g]indol-8(1H)-one core scaffold.	Hydrogen	88-90	CDC like kinase 1	Homo sapiens	23-26
26200797-12	2015	Disorder of PF6(-) anion is not observed in the LS state but in the HS state.	Hydrogen	68-70	sperm associated antigen 17	Homo sapiens	12-15
29780435-2	2018	Visible light irradiation of the porphyrin-covered TiO2 NTs under cathodic polarization up to -0.3 V vs. Normal hydrogen electrode (NHE) photocatalytically produces H2O2 in pH neutral electrolyte, at room temperature and without need of sacrificial electron donors.	Hydrogen	112-120	solute carrier family 9 member C1	Homo sapiens	132-135
26092203-5	2015	Daily repeated exposure to 1h of immobilization reduced the ACTH response to the stressor, regardless of the genotype, demonstrating that adaptation occurred to the same extent in absence of CB1R.	Hydrogen	27-29	pro-opiomelanocortin-alpha	Mus musculus	60-64
29546986-7	2018	Moreover, we present the first direct evidence for formation of a CH   O hydrogen bond between an MBP and 5-methylcytosine by using experimental (NMR) and quantum mechanical chemical shift analysis of the mC methyl protons.	Hydrogen	73-81	myelin basic protein	Homo sapiens	98-101
26108919-2	2015	The RGO/SnO2 QD based sensor shows a high response of ~89.3% to H2 and ~92.4% to LPG for 500 ppm test gas concentration at operating temperatures of 200  C and 250  C, respectively.	Hydrogen	64-66	strawberry notch homolog 1	Homo sapiens	8-11
26108919-3	2015	Further, the RGO/SnO2 QD based sensor shows good selectivity for H2 and LPG in the presence of other interfering gases such as ammonia, chloroform, toluene, benzene, acetone, n-butylacetate, acetic acid and formic acid.	Hydrogen	65-67	strawberry notch homolog 1	Homo sapiens	17-20
29577153-6	2018	IAPP and Abeta42 displayed marked differences in formation of oligomeric species, as observed by 1D 1H, pulsed-field gradient (PFG) diffusion and saturation transfer difference (STD) NMR experiments.	Hydrogen	100-102	islet amyloid polypeptide	Homo sapiens	0-4
26197239-9	2015	According to the AE model, the familiality-estimate h2 of YKL-40 was 0.45 (SE 0.13).	Hydrogen	52-54	chitinase 3 like 1	Homo sapiens	58-64
29561002-7	2018	Zn-MOF 1 with openly accessible Lewis basic sites exhibited selective sorption of CO2 over N2, H2, and CH4 at low temperature.	Hydrogen	95-97	lysine acetyltransferase 8	Homo sapiens	3-6
25903134-4	2015	Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and SPR interaction analysis on a library of lysine replacement variants as two independent approaches, we demonstrate that the interaction between factor VIII (FVIII) and LRP1 occurs over an extended surface containing multiple lysine residues.	Hydrogen	6-14	coagulation factor VIII	Homo sapiens	209-220
25903134-4	2015	Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and SPR interaction analysis on a library of lysine replacement variants as two independent approaches, we demonstrate that the interaction between factor VIII (FVIII) and LRP1 occurs over an extended surface containing multiple lysine residues.	Hydrogen	6-14	coagulation factor VIII	Homo sapiens	222-227
29512246-5	2018	By virtue of the abundant edge sites and excellent electrical transport property, such vertical 1T-TaS2 is employed as high-efficiency electrocatalysts in the hydrogen evolution reaction, featured with rather low Tafel slopes  67-82 mV dec-1 and an ultrahigh exchange current density  67.61 microA cm-2 .	Hydrogen	159-167	deleted in esophageal cancer 1	Homo sapiens	236-241
25882412-4	2015	The aggregation of AuNPs is accelerated by TGA(2-), due to the strong hydrogen-bonds (NH OC and OH OC) formed between TGA(2)(-) and DA.	Hydrogen	70-78	T-box transcription factor 1	Homo sapiens	43-46
25882412-4	2015	The aggregation of AuNPs is accelerated by TGA(2-), due to the strong hydrogen-bonds (NH OC and OH OC) formed between TGA(2)(-) and DA.	Hydrogen	70-78	T-box transcription factor 1	Homo sapiens	118-121
27649550-3	2016	Crystal structure analysis, high-level quantum chemistry (QC) calculations and combined quantum mechanics/molecular mechanics (QM/MM) modeling revealed that halogen substitution at position 3 of the benzene moiety of peptide Phe3 residue can constitute a putative halogen bonding, which is shown to be geometrically perpendicular to and energetically independent of a native hydrogen bonding that share a common carbonyl oxygen acceptor.	Hydrogen	375-383	dihydrolipoamide dehydrogenase	Homo sapiens	225-229
26035438-0	2015	Probing the Hydrogen Bonding of the Ferrous-NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance.	Hydrogen	12-20	nitric oxide synthase 1	Homo sapiens	62-66
28916982-9	2018	Here we report nearly complete 1H, 13C and 15N resonance assignments of Est3 from the yeast Hansenula polymorpha.	Hydrogen	31-33	telomerase subunit EST3	Saccharomyces cerevisiae S288C	72-76
26035438-4	2015	In this work, pulsed electron-nuclear double resonance (ENDOR) spectroscopy was used to probe the hydrogen bonding of the NO ligand in the ferrous-NO heme center of neuronal NOS (nNOS) without a substrate and with L-Arg or N-hydroxy-L-arginine (NOHA) substrates.	Hydrogen	98-106	nitric oxide synthase 1	Homo sapiens	165-177
26035438-4	2015	In this work, pulsed electron-nuclear double resonance (ENDOR) spectroscopy was used to probe the hydrogen bonding of the NO ligand in the ferrous-NO heme center of neuronal NOS (nNOS) without a substrate and with L-Arg or N-hydroxy-L-arginine (NOHA) substrates.	Hydrogen	98-106	nitric oxide synthase 1	Homo sapiens	179-183
25933199-5	2015	Addition of H2 during the growth reaction enables selective determination of either n-type SnS2 or p-type SnS 2D crystal of dissimilar energy band gap of 2.77 eV (SnS2) or 1.26 eV (SnS) as a final product.	Hydrogen	12-14	sodium voltage-gated channel alpha subunit 11	Homo sapiens	91-95
25933199-5	2015	Addition of H2 during the growth reaction enables selective determination of either n-type SnS2 or p-type SnS 2D crystal of dissimilar energy band gap of 2.77 eV (SnS2) or 1.26 eV (SnS) as a final product.	Hydrogen	12-14	sodium voltage-gated channel alpha subunit 11	Homo sapiens	163-167
27555551-10	2016	Biochemically, hydrogen inhalation decreased brain caspase-3, 3-nitrotyrosine and 8-hydroxy-2-deoxyguanosine-positive cells and inflammation factors concentration.	Hydrogen	15-23	caspase 3	Rattus norvegicus	51-60
29328989-9	2018	Molecular docking indicated that both hydrogen bonds formation and hydrophobic interactions significantly contributed to the interaction between phthalate monoesters and UGT isoforms.	Hydrogen	38-46	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	170-173
27587587-8	2016	The inspection of extrahelical positioning of the AP sites, bulge and non Watson-Crick hydrogen bonding corroborates the experimental measurements of repair efficiencies by bacterial or human AP endonucleases Nfo and APE1, respectively.	Hydrogen	87-95	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	217-221
25818978-11	2015	CONCLUSIONS: H2 plays a significant role in regulating the release of the inflammatory cytokine HMGB1 in septic mice, which is partially mediated through the activation of HO-1 as a downstream molecule of Nrf2.	Hydrogen	13-15	high mobility group box 1	Mus musculus	96-101
25739357-2	2015	We hypothesized that HS-induced enhanced vascular relaxation through A2AAR and epoxyeicosatrienoic acid (EETs) is dependent on peroxisome proliferator-activated receptor gamma (PPARgamma) and ATP-sensitive potassium channels (KATP channels) in A2AAR(+/+) mice, while HS-induced vascular contraction to adenosine is dependent on soluble epoxide hydrolase (sEH) that degrades EETs in A2AAR(-/-) mice.	Hydrogen	21-23	adenosine A2a receptor	Mus musculus	69-74
25739357-2	2015	We hypothesized that HS-induced enhanced vascular relaxation through A2AAR and epoxyeicosatrienoic acid (EETs) is dependent on peroxisome proliferator-activated receptor gamma (PPARgamma) and ATP-sensitive potassium channels (KATP channels) in A2AAR(+/+) mice, while HS-induced vascular contraction to adenosine is dependent on soluble epoxide hydrolase (sEH) that degrades EETs in A2AAR(-/-) mice.	Hydrogen	21-23	peroxisome proliferator activated receptor gamma	Mus musculus	127-175
25739357-2	2015	We hypothesized that HS-induced enhanced vascular relaxation through A2AAR and epoxyeicosatrienoic acid (EETs) is dependent on peroxisome proliferator-activated receptor gamma (PPARgamma) and ATP-sensitive potassium channels (KATP channels) in A2AAR(+/+) mice, while HS-induced vascular contraction to adenosine is dependent on soluble epoxide hydrolase (sEH) that degrades EETs in A2AAR(-/-) mice.	Hydrogen	21-23	peroxisome proliferator activated receptor gamma	Mus musculus	177-186
29044685-11	2018	The CPA-induced activation of NF-kappaB signals appeared to cause CSE overexpression in the bladder, contributing to bladder pain and in part swelling, possibly through H2 S/Cav 3.2 signaling.	Hydrogen	169-171	cystathionase (cystathionine gamma-lyase)	Mus musculus	66-69
25739357-2	2015	We hypothesized that HS-induced enhanced vascular relaxation through A2AAR and epoxyeicosatrienoic acid (EETs) is dependent on peroxisome proliferator-activated receptor gamma (PPARgamma) and ATP-sensitive potassium channels (KATP channels) in A2AAR(+/+) mice, while HS-induced vascular contraction to adenosine is dependent on soluble epoxide hydrolase (sEH) that degrades EETs in A2AAR(-/-) mice.	Hydrogen	21-23	adenosine A2a receptor	Mus musculus	244-249
25739357-2	2015	We hypothesized that HS-induced enhanced vascular relaxation through A2AAR and epoxyeicosatrienoic acid (EETs) is dependent on peroxisome proliferator-activated receptor gamma (PPARgamma) and ATP-sensitive potassium channels (KATP channels) in A2AAR(+/+) mice, while HS-induced vascular contraction to adenosine is dependent on soluble epoxide hydrolase (sEH) that degrades EETs in A2AAR(-/-) mice.	Hydrogen	21-23	adenosine A2a receptor	Mus musculus	244-249
27733124-14	2016	CONCLUSIONS: The results suggest that 10 % HS could alleviate cerebral oedema possibly through reducing the ischemia induced BBB permeability as a consequence of inhibiting VEGF-VEGFR2-mediated down-regulation of ZO-1, claudin-5.	Hydrogen	43-45	claudin 5	Rattus norvegicus	219-228
29451289-5	2018	Owing to this trade-off, the Pt complex with a moderate hydrogen bonding acceptor, PF6-, most effectively shows dimer emission.	Hydrogen	56-64	sperm associated antigen 17	Homo sapiens	83-86
27552660-1	2016	We report on potential energies for the transition state, reactant, and product complexes along the reaction pathways for hydrogen transfer reactions to hydroperoxyl radical from formaldehyde H2CO + HO2   HCO + H2O2 and another hydroperoxyl radical 2HO2   H2O2 + O2 in the presence of one carbon dioxide molecule.	Hydrogen	122-130	heme oxygenase 2	Homo sapiens	199-202
27722466-2	2016	In this work, aluminium boride, AlB2, has been investigated as a boron source for the formation of borohydrides under hydrogen pressures of p(H2) = 100 or 600 bar at elevated temperatures (350 or 400  C).	Hydrogen	118-126	afamin	Homo sapiens	32-36
27722466-2	2016	In this work, aluminium boride, AlB2, has been investigated as a boron source for the formation of borohydrides under hydrogen pressures of p(H2) = 100 or 600 bar at elevated temperatures (350 or 400  C).	Hydrogen	142-144	afamin	Homo sapiens	32-36
25818040-4	2015	In the present study, systemic corticosterone (CORT; 25mg/kg) administration 1h after fear conditioning did not impair the consolidation process but significantly suppressed the return of fear evoked by a subthreshold conditioning (SC) procedure and elevated platform (EP) stress.	Hydrogen	77-79	cortistatin	Rattus norvegicus	47-51
26064449-2	2015	Sodium-hydrogen exchange (NHE) is an important contributor to pHi control in PASMCs.	Hydrogen	7-15	solute carrier family 9 member C1	Homo sapiens	26-29
26064449-2	2015	Sodium-hydrogen exchange (NHE) is an important contributor to pHi control in PASMCs.	Hydrogen	7-15	glucose-6-phosphate isomerase	Homo sapiens	62-65
29187296-5	2018	This work presents a concise appraisal of adsorption properties of MOFs and graphene-MOF hybrids toward CO2, volatile organic compounds, hydrogen and methane.	Hydrogen	137-145	lysine acetyltransferase 8	Homo sapiens	67-70
25933136-4	2015	The results are interpreted using auxiliary molecular dynamics (MD) simulation data in order to correlate the observed eta(T,x) trends with the interactions in each mixture, including the balance between electrostatic forces and hydrogen bonding.	Hydrogen	229-237	endothelin receptor type A	Homo sapiens	119-122
26178498-0	2015	[Effects of hydrogen-rich saline on Akt/GSK3beta signaling pathways and cardiac function during myocardial ischemia-reperfusion in rats].	Hydrogen	12-20	glycogen synthase kinase 3 beta	Rattus norvegicus	40-48
26178498-1	2015	OBJECTIVE: To explore the effects of hydrogen-rich saline on Akt/GSK3beta signaling pathways and cardiac function during myocardial ischemia-reperfusion (I/R) in rats.	Hydrogen	37-45	glycogen synthase kinase 3 beta	Rattus norvegicus	65-73
27154288-10	2016	Importantly, the canonical Wnt pathway inhibitor DKK1 blocked the osteogenesis effect and rescued the ratio of RANKL/OPG in PDLSCs under force treatment for 1h.	Hydrogen	157-159	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	49-53
27454617-5	2016	The molecular docking studies were performed to elucidate the binding modes of the compounds with the GSK-3beta target and two crucial interactions namely, hydrogen bond formation with Val 135 and Lys 183 residues in the active site of GSK-3beta were observed.	Hydrogen	156-164	glycogen synthase kinase 3 beta	Homo sapiens	236-245
25903303-3	2015	In PRDM9, two conserved tyrosine residues Tyr357 and Tyr276 surrounding the amino group of the substrate lysine may influence the methylation activity through hydrogen bond interactions with AdoMet or the substrate lysine.	Hydrogen	159-167	PR/SET domain 9	Homo sapiens	3-8
29317221-6	2018	The perturbations identify a local network of hydrogen bonds and salt bridges that is more extended than previously thought, and includes interactions between the catalytic loop and the alpha2/alpha3 turn in the PPIase core.	Hydrogen	46-54	peptidylprolyl isomerase like 3	Homo sapiens	212-218
25511009-2	2015	It exhibits an excellent solar absorption and a record-breaking quantum yield (Phi = 46%) and a high photon-hydrogen energy conversion efficiency (eta = 34%,) for solar photocatalytic H2 production, which are all higher than that of the black hydrogen-doped TiO2 (Phi = 35%, eta = 24%).	Hydrogen	108-116	endothelin receptor type A	Homo sapiens	147-150
29378123-0	2018	Tuning the Strength of the Resonance-Assisted Hydrogen Bond in o-Hydroxybenzaldehyde by Substitution in the Aromatic Ring1.	Hydrogen	46-54	ring finger protein 1	Homo sapiens	117-122
25511009-2	2015	It exhibits an excellent solar absorption and a record-breaking quantum yield (Phi = 46%) and a high photon-hydrogen energy conversion efficiency (eta = 34%,) for solar photocatalytic H2 production, which are all higher than that of the black hydrogen-doped TiO2 (Phi = 35%, eta = 24%).	Hydrogen	184-186	endothelin receptor type A	Homo sapiens	147-150
25511009-2	2015	It exhibits an excellent solar absorption and a record-breaking quantum yield (Phi = 46%) and a high photon-hydrogen energy conversion efficiency (eta = 34%,) for solar photocatalytic H2 production, which are all higher than that of the black hydrogen-doped TiO2 (Phi = 35%, eta = 24%).	Hydrogen	184-186	endothelin receptor type A	Homo sapiens	275-278
25511009-2	2015	It exhibits an excellent solar absorption and a record-breaking quantum yield (Phi = 46%) and a high photon-hydrogen energy conversion efficiency (eta = 34%,) for solar photocatalytic H2 production, which are all higher than that of the black hydrogen-doped TiO2 (Phi = 35%, eta = 24%).	Hydrogen	243-251	endothelin receptor type A	Homo sapiens	275-278
27578247-0	2016	Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering.	Hydrogen	27-35	collagen type XI alpha 2 chain	Homo sapiens	107-111
27578247-1	2016	During the lead generation and optimization of PARP inhibitors blocking centrosome clustering, it was discovered that increasing hydrogen bond acceptor (HBA) strength improved cellular potency but led to elevated Caco2 and MDR1 efflux and thus poor oral bioavailability.	Hydrogen	129-137	collagen type XI alpha 2 chain	Homo sapiens	47-51
29063678-5	2018	X-ray crystallography studies reveal that hydrogen bonding with the DFG motif of CDK2 is the likely mechanism of greater enzymatic potency.	Hydrogen	42-50	cyclin dependent kinase 2	Homo sapiens	81-85
27460952-7	2016	Pretreatment with TAT-SOD 1h prior to UVB radiation promoted a mean minimal erythema dose (MED) increase of 36.6+-18.4% (p=0.013&lt;0.05. n=10) compared to vehicle control.	Hydrogen	26-28	tyrosine aminotransferase	Homo sapiens	18-21
27372840-8	2016	This result was supported by computational docking models that suggest 6EUDCA forms a more extensive hydrogen bound network with FXR.	Hydrogen	101-109	nuclear receptor subfamily 1 group H member 4	Homo sapiens	129-132
25728056-3	2015	Compound 1 is a 0D discrete molecule, in which Zn(II) is in a trigonal bipyramidal coordination geometry, whereas the guest Hpta(-) as counteranion is hydrogen-bonded with the [Zn(bpz)2(H2O)3].	Hydrogen	151-159	hepatocyte growth factor	Homo sapiens	124-128
25859271-4	2015	AD3BF2D had several interactions, including hydrogen bonds, with the residues in the catalytic site of neuraminidase as identified by molecular dynamics simulation.	Hydrogen	44-52	neuraminidase 1	Homo sapiens	103-116
29487230-5	2018	Mapping studies using site-directed mutagenesis and hydrogen-deuterium exchange with mass spectrometry revealed that the lateral ridge on domain III of the envelope protein was a primary recognition epitope for our panel of strongly neutralizing MAbs.	Hydrogen	52-60	endogenous retrovirus group K member 6, envelope	Homo sapiens	156-172
27695294-6	2016	Hydrogen bonds and salt bridges played a main role in the critical binding of AS1 to BSA, and water bridges served a supporting role.	Hydrogen	0-8	prostaglandin D2 receptor	Homo sapiens	78-81
29352967-8	2018	This occurs by abstraction of the proR and proS hydrogens at C-11 and C-8, respectively, in agreement with different "head to tail" orientation in the active site.	Hydrogen	48-57	homeobox C8	Homo sapiens	70-73
27632381-7	2016	Acteoside formed hydrogen bonds with at least six residues of caspase-3: ThrA177, SerA178, GlyA238, SerB339, ArgB341 and TrpB348.	Hydrogen	17-25	caspase 3	Rattus norvegicus	62-71
29359551-5	2018	More importantly, we demonstrated that the inorganic Cu-based nanocomposite [+0.34 V vs normal hydrogen electrode (NHE)] was degradable in an endogenous H2O2 (+1.78 V vs NHE) environment.	Hydrogen	95-103	solute carrier family 9 member C1	Homo sapiens	115-118
27634255-5	2016	The main reason for huge reduction in the strength of this N-H N hydrogen bond in these complexes is due to loss of the C-H N hydrogen bond, through substitution of fluorine atoms in 2 and 6 positions, which induces major structural changes by bending the hydrogen bond and introducing the n   pi(*) interaction.	Hydrogen	65-73	chimerin 1	Homo sapiens	120-125
27634255-5	2016	The main reason for huge reduction in the strength of this N-H N hydrogen bond in these complexes is due to loss of the C-H N hydrogen bond, through substitution of fluorine atoms in 2 and 6 positions, which induces major structural changes by bending the hydrogen bond and introducing the n   pi(*) interaction.	Hydrogen	126-134	chimerin 1	Homo sapiens	120-125
27634255-5	2016	The main reason for huge reduction in the strength of this N-H N hydrogen bond in these complexes is due to loss of the C-H N hydrogen bond, through substitution of fluorine atoms in 2 and 6 positions, which induces major structural changes by bending the hydrogen bond and introducing the n   pi(*) interaction.	Hydrogen	126-134	chimerin 1	Homo sapiens	120-125
29175029-4	2018	Knocking out D3R suppressed the METH-induced increase in Pde4b in the Hip of mice 24h after the final METH injection and augmented the METH-induced increase in Atf3 in the CPu of mice 1h after the final METH injection.	Hydrogen	184-186	dopamine receptor D3	Mus musculus	13-16
27994744-0	2016	Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.	Hydrogen	7-15	complement factor D	Homo sapiens	68-87
27531909-0	2016	Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation.	Hydrogen	0-8	S100 calcium binding protein A8	Homo sapiens	103-107
29258818-5	2018	Here we used hydrogen exchange mass spectrometry (HX MS) to compare the solution conformation of Nef alone and in complexes with the SH3 or the SH3-SH2 domains of the Src-family kinase Hck.	Hydrogen	13-21	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	185-188
28858298-6	2018	The hydrogen bond mediated by crystallographic water between MS0 and His191 or Val350 of NAMPT did not exist in FK866.	Hydrogen	4-12	nicotinamide phosphoribosyltransferase	Homo sapiens	89-94
27482717-1	2016	Potential energy profiles and electronic structural interpretation of the CO and H2 binding reactions to molybdenocene and tungstenocene complexes [MCp2] (M = Mo and W, Cp = cycropentadienyl) were studied using density functional theory calculations and ab initio multiconfigurational electronic structure calculations.	Hydrogen	81-83	C-C motif chemokine ligand 8	Homo sapiens	148-152
29391908-4	2018	Using 15O-H2 PET, changes in regional cerebral blood flow (rCBF) coupled to neuronal activity were reported in states of fasting, satiation after feeding, and sensory stimulation.	Hydrogen	10-12	CCAAT/enhancer binding protein zeta	Rattus norvegicus	59-63
29209909-9	2018	Molecular dynamic simulation (MDS) of the two structures also revealed that rNAP1 dimer is more stable owing to the extensive hydrogen bonding in comparison to yNAP1.	Hydrogen	126-134	NCK-associated protein 1	Rattus norvegicus	76-81
29371621-6	2018	Most importantly, based on the simulation observation that resveratrol has a high probability of forming hydrogen bonds with sn-1 and sn-2 ester groups, we discovered a new mechanism using experimental approach, in which resveratrol protects both sn-1 and sn-2 ester bonds of DPPC and distearoyl phosphatidylcholine (DSPC) from phospholipase A1 (PLA1) and phospholipase A2 (PLA2) cleavage.	Hydrogen	105-113	lipase H	Homo sapiens	328-344
29171122-1	2018	A 2D coordination polymer containing a free ligand (Lf ), fixed by hydrogen bonds, transformed into a 3D metal-organic framework (MOF) in a single-crystal to single-crystal fashion.	Hydrogen	67-75	lysine acetyltransferase 8	Homo sapiens	102-134
29564983-7	2018	RESULTS: Ligplot analysis indicated that abietic acid had strong binding efficiency with AchE and HDAC3 receptors forming one and four hydrogen bonds respectively.	Hydrogen	135-143	histone deacetylase 3	Homo sapiens	98-103
30509471-6	2018	Besides coupling to ACS, CODH can interact with hydrogenases to couple CO oxidation to H2 formation.	Hydrogen	87-89	acyl-CoA synthetase short chain family member 2	Homo sapiens	20-23
29211071-3	2017	Interaction energies, charge transfers and hydrogen bonds between the cation and anions of each studied GDIL were investigated by DFT calculations and also AIM.	Hydrogen	43-51	GDP dissociation inhibitor 1	Homo sapiens	104-108
29088535-5	2017	This is consistent with the widely held view that cytochrome c oxidase (complex IV of the mitochondrial electron-transport system) is the principal molecular target involved in the acute toxicity of "sulfide" (H2S/HS-).	Hydrogen	214-216	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	50-70
29088535-7	2017	Respirometric measurements showed the BPAEC to possess a robust sulfide oxidizing system, which was able to out-compete cytochrome c oxidase for available H2S/HS- at micromolar concentrations.	Hydrogen	159-161	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	120-140
29263462-13	2017	CONCLUSION: Specific siRNA silencing of ATP6V0C gene inhi-bits the invasion of human prostate cancer cells in vitro by mechanism of inhibiting V-ATPase activity and then reducing the extracellular hydrogen ion concentration, inhibiting MMP-9 activation and affecting ECM degradation and reconstruction.	Hydrogen	197-205	ATPase H+ transporting V0 subunit c	Homo sapiens	40-47
28882824-4	2017	One hypothesis is that hydrogen may be bound to the mucin polymers themselves as they are convected away from the mucosal surface and eventually degraded in the stomach lumen.	Hydrogen	23-31	LOC100508689	Homo sapiens	52-57
27822979-4	2017	Our results indicate that all the 12 hits showed good CNS drug-like properties, have better binding free energy and ADME profile as compared to co-crystallized ligand with the best ligand hit retaining conserved hydrogen bond interactions with Ala-166, Thr-168, Ser-145, and Arg-61 residues in bilobatevenus fly-trap domain of mGluR2 receptor.	Hydrogen	212-220	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	327-333
25809263-2	2015	Our previous work showed that the formation of hydrogen bonds between the C-terminal residue E220 and the residues of the linker region stabilized a compact structure of TIS11d in the absence of RNA.	Hydrogen	47-55	ZFP36 ring finger protein like 2	Homo sapiens	170-176
29116740-3	2017	The hydrogen storage capacity of the material was over 300 mAh g-1 at a rate of 100 mAg-1.	Hydrogen	4-12	dentin matrix protein 1	Mus musculus	84-89
25663604-2	2015	The solid-state structures of o-PF6, m-PF6, m-ClO4, and m-BF4 showed that the cations form twisted cavities in which the anions are fixed by multiple hydrogen bonds.	Hydrogen	150-158	sperm associated antigen 17	Homo sapiens	32-35
25663604-2	2015	The solid-state structures of o-PF6, m-PF6, m-ClO4, and m-BF4 showed that the cations form twisted cavities in which the anions are fixed by multiple hydrogen bonds.	Hydrogen	150-158	sperm associated antigen 17	Homo sapiens	39-42
29091437-6	2017	X-ray crystallographic analysis reveals that 12 adopts a similar binding mode in both rat and human nNOS, in which the 2-aminopyridine and the fluorobenzene linker form crucial hydrogen bonds with glutamate and tyrosine residues, respectively.	Hydrogen	177-185	nitric oxide synthase 1	Homo sapiens	100-104
28925020-0	2017	One-Pot Synthesis of Size-Controllable Core-Shell CdS and Derived CdS@Znx Cd1-x S Structures for Photocatalytic Hydrogen Production.	Hydrogen	112-120	CD1c molecule	Homo sapiens	74-77
25775415-6	2015	Solution Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) analysis reveals an increased mobility of the thumb subdomain of RdRp in the context of the full length NS5 protein which correlates well with the analysis of the crystallographic temperature factors.	Hydrogen	9-17	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	168-171
28925020-8	2017	Furthermore, CdS@Znx Cd1-x S core-double shell structures exhibited excellent stability over 20 h of hydrogen production.	Hydrogen	101-109	CD1c molecule	Homo sapiens	21-24
29057644-4	2017	This strongly coupled structure together with the highly exposed MoS2 morphology accelerates the electron injection from graphene to the active sites of MoS2, and thus the hydrogen evolution reaction (HER) can achieve an overpotential of ~275 mV at ~-740 mA cm-2, and a Pt-like Tafel slope of ~35 mV dec-1.	Hydrogen	172-180	deleted in esophageal cancer 1	Homo sapiens	300-305
25604896-3	2015	The catalysis is fulfilled via the two-step cycle comprising: 1) the reaction of Li2NH and 3d TM(N) to form ternary nitride of LiTMN and H2, and 2) the ammoniation of LiTMN to Li2NH, TM(N) and N2 resulting in the neat reaction of 2 NH3 N2+3 H2.	Hydrogen	137-139	ATP binding cassette subfamily A member 12	Homo sapiens	81-84
25597011-3	2015	A docking study of 15 with our hTRPV1 homology model indicates that there is crucial hydrogen bonding between the ring nitrogen and the receptor, contributing to its potency.	Hydrogen	85-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-37
29259749-3	2017	Three crystal structures are reported for complexes of MIF with 3a, 4a, and 4b, which show that the desired hydrogen bond is formed with O-N distances of 2.8-3.0 A.	Hydrogen	108-116	macrophage migration inhibitory factor	Homo sapiens	55-58
29020447-0	2017	Efficiently Synergistic Hydrogen Evolution Realized by Trace Amount of Pt-Decorated Defect-Rich SnS2 Nanosheets.	Hydrogen	24-32	sodium voltage-gated channel alpha subunit 11	Homo sapiens	96-100
25650239-4	2015	Steered molecular dynamics (SMD) simulations predicted that the E47A and R33A mutations in the YS1 scaffold substantially destabilize the YS1-MBP interface by reducing the bond rupture force and the lifetime of single hydrogen bonds.	Hydrogen	218-226	myelin basic protein	Homo sapiens	142-145
25650239-5	2015	SMD simulations further indicated that the R33A mutation weakens the hydrogen binding between all scaffold residues and MBP and not just between R33 and MBP.	Hydrogen	69-77	myelin basic protein	Homo sapiens	120-123
27182431-0	2015	Excited-state hydrogen atom abstraction initiates the photochemistry of beta-2"-deoxycytidine.	Hydrogen	14-22	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	72-78
28817220-6	2017	This difference in binding affinity is largely explained by the higher stability of the hydrogen-bond networks in KLK14/HAI-1 along the simulation trajectory.	Hydrogen	88-96	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	120-125
27342729-4	2016	As early as 1h after HN2 treatment, high mDPC was achieved and the level maintained for up to 24h.	Hydrogen	12-14	MT-RNR2 like 2 (pseudogene)	Homo sapiens	21-24
25404235-4	2015	A four-point pharmacophore with two hydrogen bond acceptor, one aromatic ring and one hydrophobic feature, was generated for six highly active isothiazolone derivatives as PCAF inhibitors in order to elucidate their anticancer activity.	Hydrogen	36-44	lysine acetyltransferase 2B	Homo sapiens	172-176
29052507-4	2017	METHODS: Using 1D 1H-NMR spectroscopy, transcriptomic arrays, and flow cytometry, we observed that the density-dependent differentiation of ESCs into FLK1+ VPCs positively correlated with a shift in metabolism and cellular growth.	Hydrogen	18-20	kinase insert domain protein receptor	Mus musculus	150-154
25205294-9	2015	In conclusion, we have determined that the l-cysteine/CSE/H2 S pathway is involved in melanoma progression.	Hydrogen	58-60	cystathionase (cystathionine gamma-lyase)	Mus musculus	54-57
27444853-4	2016	For this purpose, alterations of rCBF were explored in a case-control study using H2(15)O positron emission tomography, where each group was exposed to four different conditions, including rest and different levels of non-painful electrical stimulation of the neck.	Hydrogen	82-84	CCAAT/enhancer binding protein zeta	Rattus norvegicus	33-37
28984574-3	2017	To address this deficit, we generated samples of a wild-type GPCR (A2AR) that are deuterated apart from 1H/13C NMR probes at isoleucine delta1 methyl groups, which facilitated 1H/13C methyl TROSY NMR measurements with opposing ligands.	Hydrogen	176-178	G protein-coupled receptor 166 pseudogene	Homo sapiens	61-65
25411908-0	2014	Monodisperse SnS2 nanosheets for high-performance photocatalytic hydrogen generation.	Hydrogen	65-73	sodium voltage-gated channel alpha subunit 11	Homo sapiens	13-17
27327514-9	2016	The results show that the CH3NH3(+) interacts with the PbX3(-) octahedral framework via the NH3(+) end through N(+)-HX hydrogen bonding whose strength can be tuned by the composition of halides but is insensitive to the size of the organic cations.	Hydrogen	119-127	PBX homeobox 3	Homo sapiens	55-59
28972563-9	2017	Genetic evidence suggested that in the presence of H2, Arabidopsis mutants nia2 (in particular) and nia1 (two nitrate reductases (NR)-defective mutants) exhibited defects in lateral root length.	Hydrogen	51-53	nitrate reductase 2	Arabidopsis thaliana	75-79
27328012-2	2016	In the present work, Li4(NH2)3BH4 doped Mg(NH2)2-2LiH was formed by milling the 2LiNH2-MgH2-0.2LiBH4 composite and posterior annealing under hydrogen pressure to reduce the kinetic barrier of the Li-Mg-N-H system.	Hydrogen	141-149	lipase family member N	Homo sapiens	21-24
25411908-9	2014	SnS2 nanosheets exhibit high photocatalytic H2 evolution activity of 1.06 mmol h(-1) g(-1) under simulated sunlight irradiation, much higher than that of SnS2 with different morphologies and P25-TiO2.	Hydrogen	44-46	sodium voltage-gated channel alpha subunit 11	Homo sapiens	0-4
27328012-6	2016	The presence of Li4(NH2)3BH4 in the composite stabilized the hydrogen storage capacity after successive sorption cycles.	Hydrogen	61-69	lipase family member N	Homo sapiens	16-19
28575792-7	2017	The production of hydrogen and syngas is 1.5% higher in the pilot scale gasifier as compared to TGA-MS setup.	Hydrogen	18-26	T-box transcription factor 1	Homo sapiens	96-99
27328012-9	2016	Detailed structural investigations revealed the effective influence of Li4(NH2)3BH4 in different reactions: the irreversible dehydrogenation in the presence of MgH2 and the reversible hydrogen release when it reacts with Li2Mg2(NH)3.	Hydrogen	127-135	lipase family member N	Homo sapiens	71-74
25356997-9	2014	Bet v 1-type protein folding of the NCS variant was evaluated by 1H-15N-HSQC NMR spectroscopy.	Hydrogen	65-67	delta/notch like EGF repeat containing	Homo sapiens	0-3
28589219-0	2017	1H, 13C, and 15N backbone chemical shift assignments of 4E-BP144-87 and 4E-BP144-87 bound to eIF4E.	Hydrogen	0-2	eukaryotic translation initiation factor 4E	Homo sapiens	93-98
27275663-2	2016	The nanobubbles are created between graphene and mica by reducing intercalated water to hydrogen.	Hydrogen	88-96	MHC class I polypeptide-related sequence A	Homo sapiens	49-53
25184335-6	2014	TGA and TPR analyses help to follow the reduction properties under Ar/5% H2 and show high Pr reducible rates at low temperatures (T &lt; 250  C).	Hydrogen	73-75	T-box transcription factor 1	Homo sapiens	0-3
27634290-6	2017	The binding energy decomposition indicated that the hydrophobic and hydrogen bond interactions play important roles for the binding of compounds to P2Y12.	Hydrogen	68-76	purinergic receptor P2Y12	Homo sapiens	148-153
26292580-5	2016	As anticipated in the phorbol ester binding, hydrogen bonds are formed through the backbone atoms of Thr242, Leu251, and Gly253 of PKC.	Hydrogen	45-53	protein kinase C delta	Homo sapiens	131-134
28760780-6	2017	In KCa3.1, SKA-121 forms an additional hydrogen bond network with R362.	Hydrogen	39-47	potassium calcium-activated channel subfamily N member 4	Homo sapiens	3-9
26292580-7	2016	For the PKC delta-bryostatin complex, hydrogen bonds are formed between the Gly253 backbone carbonyl and the C30 carbomethoxy substituent of the ligand.	Hydrogen	38-46	protein kinase C delta	Homo sapiens	8-17
26851769-5	2016	NAC 50mg/kg/d administered 1h after initiation of hypothermia significantly decreased iNOS expression and caspase 3 activation in the injured hemisphere versus hypothermia alone.	Hydrogen	27-29	caspase 3	Rattus norvegicus	106-115
25044684-0	2014	Photothermal conversion of CO2 into CH4 with H2 over Group VIII nanocatalysts: an alternative approach for solar fuel production.	Hydrogen	45-47	cytochrome c oxidase subunit 8A	Homo sapiens	59-63
25140613-1	2014	Molybdenum phosphide was adopted as a new electrocatalyst for the hydrogen evolution reaction for the first time, exhibiting an excellent electrocatalytic activity with a small Tafel slope of 60 mV dec(-1), which is amongst the most active, acid-stable, earth abundant HER electrocatalysts reported to date.	Hydrogen	66-74	deleted in esophageal cancer 1	Homo sapiens	198-204
28760780-7	2017	In contrast, NS309 sits more "forward" and directly hydrogen bonds with R362 in KCa3.1.	Hydrogen	52-60	potassium calcium-activated channel subfamily N member 4	Homo sapiens	80-86
27393453-3	2016	The binding pocket sites, the internal energy, the hydrogen bond interactions and the interacting amino acid residues of the human GM-CSFR with Withanolides were analyzed through molecular docking method.	Hydrogen	51-59	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	131-138
28849153-8	2017	These results demonstrated that H2 significantly reduced the number of apoptotic cells, and the protein expression of p38 MAPK and caspase-3, compared with the IR group.	Hydrogen	32-34	mitogen activated protein kinase 14	Rattus norvegicus	118-121
26800298-11	2016	In addition, our MD simulations exhibit additional strong hydrogen bond networks between the protein and PLP: the phosphate group is held in place by the donation of at least three hydrogen bonds while the carbonyl oxygen of the pyridine ring interacts with Gln301; Phe181 forms a pi-pi stacking interaction with the pyridine ring and works as a gate keeper with the assistance of Val300.	Hydrogen	58-66	pyridoxal phosphatase	Homo sapiens	105-108
26800298-11	2016	In addition, our MD simulations exhibit additional strong hydrogen bond networks between the protein and PLP: the phosphate group is held in place by the donation of at least three hydrogen bonds while the carbonyl oxygen of the pyridine ring interacts with Gln301; Phe181 forms a pi-pi stacking interaction with the pyridine ring and works as a gate keeper with the assistance of Val300.	Hydrogen	181-189	pyridoxal phosphatase	Homo sapiens	105-108
24037519-0	2014	1H, 13C and 15N resonance assignments of the VWA domain of Saccharomyces cerevisiae Rpn10, a regulatory subunit of 26S proteasome.	Hydrogen	0-2	proteasome regulatory particle base subunit RPN10	Saccharomyces cerevisiae S288C	84-89
24469996-0	2014	1H, 15N, and 13C backbone chemical shift assignment of titin domains A59-A60 and A60 alone.	Hydrogen	0-2	titin	Homo sapiens	55-60
25099487-8	2014	o-HB forms the least hydrogen bonds and is therefore the most mobile, and p-HB, which forms the most hydrogen bonds with water, is the least mobile isomer.	Hydrogen	101-109	prohibitin 1	Homo sapiens	74-78
28849153-8	2017	These results demonstrated that H2 significantly reduced the number of apoptotic cells, and the protein expression of p38 MAPK and caspase-3, compared with the IR group.	Hydrogen	32-34	caspase 3	Rattus norvegicus	131-140
25061635-2	2014	The immobilized biomimetic [Fe2S2] catalyst inside the MOF shows great improvement in hydrogen generation compared to the reference homogeneous catalyst complex 1.	Hydrogen	86-94	lysine acetyltransferase 8	Homo sapiens	55-58
28841025-0	2017	Comparative Study of REDOR and CPPI Derived Order Parameters by 1H-Detected MAS NMR and MD Simulations.	Hydrogen	64-66	cathepsin C	Homo sapiens	31-35
24827113-11	2014	CONCLUSIONS AND IMPLICATIONS: Low and continuous exposure to H2 S targets metabolic processes and pH homeostasis in cancer cells, potentially serving as a novel and selective anti-cancer strategy.	Hydrogen	61-63	glucose-6-phosphate isomerase	Homo sapiens	98-100
27254650-3	2016	Meanwhile, the catalytic effect of water, water dimers and water trimers is mainly taken from the contribution of a single water vapor molecule, since the total effective rate constant of HO2H2O + HS and H2OHO2 + HS reactions was, respectively, larger by 7-9 and 9-12 orders of magnitude than that of SH + HO2(H2O)2 and SH + HO2(H2O)3 reactions.	Hydrogen	197-199	heme oxygenase 2	Homo sapiens	188-191
28861561-4	2017	In the potential region of hydrogen underpotential deposition (HUPD), C1 can be separated into two parts, C1a and C1b.	Hydrogen	27-35	endogenous retrovirus group K member 1	Homo sapiens	106-109
27114072-1	2016	The reaction of Fe(eta-C5H4NHC(O)PPh2)2 () with PtX2(PPh3)2 selectively formed cage-shaped complexes formulated as [(PtX)4()6]X4 CHCl3 (X = Cl, Br), in which the four square-planar Pt fragments were situated at each vertex and the six s were located in each side of a tetrahedral framework and hydrogen bonds existed between the NH groups in s and X(-) ions inside the cage.	Hydrogen	294-302	endothelin receptor type A	Homo sapiens	19-22
25038572-9	2014	The analysis of the model structure of N212D APE1 provides evidence for alternate hydrogen bonding between Asn-212 and Asp-210 residues, whereas N212A possesses an extended active site pocket due to Asn removal.	Hydrogen	82-90	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	45-49
28857556-1	2017	In this study, we report the electrocatalytic behavior of the neutral, monomeric Cu(II) complex of diacetyl-bis(N-4-methyl-3-thiosemicarbazonato), CuL1, for metal-assisted ligand-centered hydrogen evolution in acetonitrile and dimethylformamide.	Hydrogen	188-196	cullin 1	Homo sapiens	147-151
25036847-1	2014	In this work, we had investigated sputtering deposition of p-type SnO using the widely used and robust SnO2 target in a hydrogen-containing reducing atmosphere.	Hydrogen	120-128	strawberry notch homolog 1	Homo sapiens	66-69
25036847-3	2014	Results show that polycrystalline and SnO-dominant films could be readily obtained by carefully controlling the hydrogen gas ratio in the sputtering gas and the extent of reduction reaction.	Hydrogen	112-120	strawberry notch homolog 1	Homo sapiens	38-41
26975372-2	2016	Studies investigating mechanisms whereby peptide ligands activate GLP-1R have utilized mutagenesis, receptor chimeras, photo-affinity labeling, hydrogen-deuterium exchange, and crystallography of the ligand-binding ectodomain to establish receptor homology models.	Hydrogen	144-152	glucagon like peptide 1 receptor	Homo sapiens	66-72
28857556-4	2017	Gas analysis from controlled potential electrolysis confirms CuL1 as an electrocatalyst to produce H2 with a minimum Faradaic efficiency of 81% and turnover numbers as high as 73 while showing no sign of degradation over 23 h. The H2 evolution reaction (HER) was probed using deuterated acid, demonstrating a kinetic isotope effect of 7.54.	Hydrogen	99-101	cullin 1	Homo sapiens	61-65
27174982-5	2016	More important, the Pd1/TiO2-EG system could activate H2 in a heterolytic pathway, leading to a catalytic enhancement in hydrogenation of aldehydes by a factor of more than 55.	Hydrogen	54-56	programmed cell death 1	Homo sapiens	20-23
29082075-3	2017	We utilize terahertz absorption spectroscopy and molecular dynamics simulation to investigate the variation of binding-induced collective vibration of hydrogen bond network in a mixed solution of MUC1 peptide and anti-MUC1 aptamer.	Hydrogen	151-159	mucin 1, cell surface associated	Homo sapiens	196-200
25027934-6	2014	Molecular docking analysis showed that 11 was hydrogen bonded with the Arg-31 and Gln-110 residues of the IKKbeta.	Hydrogen	46-54	activity regulated cytoskeleton associated protein	Homo sapiens	71-77
29082075-3	2017	We utilize terahertz absorption spectroscopy and molecular dynamics simulation to investigate the variation of binding-induced collective vibration of hydrogen bond network in a mixed solution of MUC1 peptide and anti-MUC1 aptamer.	Hydrogen	151-159	mucin 1, cell surface associated	Homo sapiens	218-222
28571783-8	2017	Bic was found to make hydrogen bonding and hydrophobic interactions with BSA by spectroscopic studies and molecular docking.	Hydrogen	22-30	MIR155 host gene	Homo sapiens	0-3
25068594-1	2014	The hydrogen bond between formaldehyde and the luminescent metal-organic framework (MOF) [Zn(NH2bdc)(bix)]n was investigated using density functional theory and time-dependent density functional theory.	Hydrogen	4-12	lysine acetyltransferase 8	Homo sapiens	59-88
25068594-4	2014	Strengthening of the hydrogen bond weakens the radioactive transition of [Zn(NH2bdc)(bix)]n, which thus leads to a luminescence decrease or quenching phenomenon, meaning that the luminescent MOF [Zn(NH2bdc)(bix)]n may be applied to the detection of formaldehyde.	Hydrogen	21-29	lysine acetyltransferase 8	Homo sapiens	191-194
24937348-11	2014	In addition, hydrogen-rich saline treatment reduced caspase-3 activity in cortex and hippocampus after cardiac arrest/resuscitation.	Hydrogen	13-21	caspase 3	Rattus norvegicus	52-61
28792029-2	2017	The crystal structure of [Mn(sal-N-1,5,8,12)]PF6, a complex known to exhibit an abrupt SCO behavior with an 8 K hysteresis window, reveals that this complex has a temperature-dependent anion order-disorder transition that disrupts the hydrogen-bonding chain upon SCO, indicating that hydrogen bonds between cations and anions greatly influence the magnetic properties.	Hydrogen	235-243	sperm associated antigen 17	Homo sapiens	45-48
25010490-3	2014	Complexes that contain a dihydrogen bond or a OH   X interaction are the most stable in comparison with other possible BeX2 complexation patterns in which no other weak interactions are involved apart from the beryllium bond.	Hydrogen	25-35	brain expressed X-linked 2	Homo sapiens	119-123
24939240-1	2014	To develop a metal-organic framework (MOF) for hydrogen storage, SNU-200 incorporating a 18-crown-6 ether moiety as a specific binding site for selected cations has been synthesized.	Hydrogen	47-55	lysine acetyltransferase 8	Homo sapiens	13-42
28792029-2	2017	The crystal structure of [Mn(sal-N-1,5,8,12)]PF6, a complex known to exhibit an abrupt SCO behavior with an 8 K hysteresis window, reveals that this complex has a temperature-dependent anion order-disorder transition that disrupts the hydrogen-bonding chain upon SCO, indicating that hydrogen bonds between cations and anions greatly influence the magnetic properties.	Hydrogen	284-292	sperm associated antigen 17	Homo sapiens	45-48
24674915-4	2014	The Raman study also gives an evidence of breaking of weak intermolecular hydrogen bonds associated with ester groups and formation of new hydrogen bonds through CN bond at Cr SmA phase transition.	Hydrogen	139-147	survival of motor neuron 1, telomeric	Homo sapiens	176-179
28544420-5	2017	Rare eta2 coordinated and HX (X=F or OH) associated H2 complexes are produced during interaction with a single ion of stronger acidity, H2 F+ or H3 O+ .	Hydrogen	52-54	DNA polymerase iota	Homo sapiens	5-9
25007222-2	2014	In this issue of Structure, Guttman and colleagues use hydrogen-deuterium exchange (HDX) to provide new insights into the structure of the HIV-1 Env trimer and enhance our understanding of how HIV-1 Env is activated for virus fusion.	Hydrogen	55-63	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	145-148
25007222-2	2014	In this issue of Structure, Guttman and colleagues use hydrogen-deuterium exchange (HDX) to provide new insights into the structure of the HIV-1 Env trimer and enhance our understanding of how HIV-1 Env is activated for virus fusion.	Hydrogen	55-63	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	199-202
28817657-4	2017	Ferredoxin-NADP reductase, present in bacteria in genus Azotobacter, is an important enzyme for NADH/NAD+ equilibrium regulation in hydrogen production.	Hydrogen	132-140	ferredoxin reductase	Homo sapiens	0-25
28812535-11	2017	For SLC3A1, functional information is currently insufficient to make confident predictions but mutations often result in the loss of hydrogen bonds and largely appear to affect protein stability.	Hydrogen	133-141	solute carrier family 3 member 1	Homo sapiens	4-10
24895096-2	2014	The ZIS MSs co-loaded with CQDs and Pt exhibited a high photocatalytic H2 production rate of 1032.2 mumol h(-1)  g(-1) with an apparent quantum efficiency of 2.2 % (420 nm) in triethanolamine aqueous solution under visible-light irradiation, which was much higher than the respective photocatalytic rates of pure ZIS, Pt loaded ZIS, and CQDs-decorated ZIS.	Hydrogen	71-73	zinc finger RANBP2-type containing 2	Homo sapiens	4-7
24895096-2	2014	The ZIS MSs co-loaded with CQDs and Pt exhibited a high photocatalytic H2 production rate of 1032.2 mumol h(-1)  g(-1) with an apparent quantum efficiency of 2.2 % (420 nm) in triethanolamine aqueous solution under visible-light irradiation, which was much higher than the respective photocatalytic rates of pure ZIS, Pt loaded ZIS, and CQDs-decorated ZIS.	Hydrogen	71-73	zinc finger RANBP2-type containing 2	Homo sapiens	313-316
24895096-2	2014	The ZIS MSs co-loaded with CQDs and Pt exhibited a high photocatalytic H2 production rate of 1032.2 mumol h(-1)  g(-1) with an apparent quantum efficiency of 2.2 % (420 nm) in triethanolamine aqueous solution under visible-light irradiation, which was much higher than the respective photocatalytic rates of pure ZIS, Pt loaded ZIS, and CQDs-decorated ZIS.	Hydrogen	71-73	zinc finger RANBP2-type containing 2	Homo sapiens	313-316
24895096-2	2014	The ZIS MSs co-loaded with CQDs and Pt exhibited a high photocatalytic H2 production rate of 1032.2 mumol h(-1)  g(-1) with an apparent quantum efficiency of 2.2 % (420 nm) in triethanolamine aqueous solution under visible-light irradiation, which was much higher than the respective photocatalytic rates of pure ZIS, Pt loaded ZIS, and CQDs-decorated ZIS.	Hydrogen	71-73	zinc finger RANBP2-type containing 2	Homo sapiens	313-316
28516506-1	2017	The geometric and electronic ground-state structures of 30 isomers of six MS4 molecules (M=Group 8 metals Fe, Ru, Os, Hs, Sm, and Pu) have been studied by using quantum-chemical density functional theory and correlated wavefunction approaches.	Hydrogen	118-120	MS4	Homo sapiens	74-77
24836941-0	2014	Development of a Ru complex-incorporated MOF photocatalyst for hydrogen production under visible-light irradiation.	Hydrogen	63-71	lysine acetyltransferase 8	Homo sapiens	41-44
24836941-2	2014	Ti-MOF-Ru(tpy)2 promotes photocatalytic hydrogen production from water containing a sacrificial electron donor under visible-light irradiation up to 620 nm.	Hydrogen	40-48	lysine acetyltransferase 8	Homo sapiens	3-6
28661686-6	2017	The tetramers share several features with structures reported for IAPP fibrils and demonstrate the importance of hydrogen bonding and hydrophobic interactions in the oligomerization of IAPP-derived peptides.	Hydrogen	113-121	islet amyloid polypeptide	Homo sapiens	185-189
24892388-6	2014	Stable heterointeractions between hIAPP and rIAPP were shown to arise from hydrophobic contacts and hydrogen bonds at the interface, particularly at N- and C-terminal beta-sheet regions.	Hydrogen	100-108	islet amyloid polypeptide	Homo sapiens	34-39
28614179-9	2017	Moreover, H2 treatment markedly improved blood-brain barrier integrity and reduced caspase-3 activity in the hippocampus of surgery-challenged animals.	Hydrogen	10-12	caspase 3	Rattus norvegicus	83-92
28651979-4	2017	Molecular docking of 4d to ATP binding site of CDK9 kinase demonstrated a new hydrogen bonding between F atom of 4-(3-fluorobenzyloxy) group and ASN116 residue, compared with the positive control, LEE011.	Hydrogen	78-86	cyclin-dependent kinase 9 (CDC2-related kinase)	Mus musculus	47-51
24763362-3	2014	Among the synthesized compounds, four nepodin (1f, 1g, 1h and 1i) and three chrysophanol (2e, 2f and 2h) derivatives displayed more pronounced COX-2 inhibition than their respective lead molecule.	Hydrogen	55-57	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	143-148
28388287-10	2017	Our study shows that the N109T variant may directly or indirectly weaken amino acid interactions and hydrogen bond networks of the DAZL protein, which we predicted may result in altered DAZL protein function.	Hydrogen	101-109	deleted in azoospermia like	Homo sapiens	131-135
24644296-11	2014	The adsorption of NH3 as a probe molecule indicates that the acidity can affect the hydrogen-bonding interaction between (N-H   O2) and (N   H-O2).	Hydrogen	84-92	heme oxygenase 2	Homo sapiens	141-145
28388287-10	2017	Our study shows that the N109T variant may directly or indirectly weaken amino acid interactions and hydrogen bond networks of the DAZL protein, which we predicted may result in altered DAZL protein function.	Hydrogen	101-109	deleted in azoospermia like	Homo sapiens	186-190
28654298-4	2017	Combined with in situ ambient-pressure X-ray photoelectron spectroscopy, IR, and Raman spectroscopic studies, the results together point to a heterolytic dissociation mechanism of H2 over ceria, leading to either homolytic products (surface OHs) on a close-to-stoichiometric ceria surface or heterolytic products (Ce-H and OH) with the presence of induced oxygen vacancies in ceria.	Hydrogen	180-182	epoxide hydrolase 2	Homo sapiens	314-325
24815319-4	2014	This study presents clear evidence that the mechanical properties of MOF materials can be substantially tuned via hydrogen-bonding interactions.	Hydrogen	114-122	lysine acetyltransferase 8	Homo sapiens	69-72
24826797-3	2014	Herein we demonstrate that Si-doped GaN nanowires (NWs) with a 97% rationally constructed m-plane can directly convert methane into benzene and molecular hydrogen under ultraviolet (UV) illumination at rt.	Hydrogen	154-162	gigaxonin	Homo sapiens	36-39
24444018-7	2014	Furthermore, we observed many notable changes (such as conformation, residues motions, hydrogen bonds, and binding free energy) in the mutated GSK3beta-PKB complexes.	Hydrogen	87-95	glycogen synthase kinase 3 beta	Homo sapiens	143-151
28627884-0	2017	Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Calcium Binding Properties and Allosteric Regulation of Downstream Regulatory Element Antagonist Modulator (DREAM).	Hydrogen	0-8	potassium voltage-gated channel interacting protein 3	Homo sapiens	110-160
24673410-11	2014	In conclusion, H2 S donors protected BBB integrity following experimental stroke possibly by acting through NF-kappaB inhibition to suppress neuroinflammation induction of MMP9 and NOX4-derived free radicals.	Hydrogen	15-17	NADPH oxidase 4	Homo sapiens	181-185
28627884-0	2017	Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Calcium Binding Properties and Allosteric Regulation of Downstream Regulatory Element Antagonist Modulator (DREAM).	Hydrogen	0-8	potassium voltage-gated channel interacting protein 3	Homo sapiens	162-167
28627884-4	2017	Here we describe the application of hydrogen-deuterium exchange mass spectrometry (HDX-MS) and site-directed mutagenesis to investigate the Ca2+ binding properties and the subsequent conformational changes of full-length DREAM.	Hydrogen	36-44	potassium voltage-gated channel interacting protein 3	Homo sapiens	221-226
27773654-2	2017	With the increase of magnetic field strength, whereas localized 1H-MRS benefits from higher sensitivity and spectral dispersion, it is challenged by increased spatial inhomogeneity of the B0 and B1 fields, larger chemical shift displacement error, and shortened T2 relaxation times of metabolites.	Hydrogen	64-66	CD80 molecule	Homo sapiens	188-197
24648448-6	2014	An equivalent hydrogen bond cannot be formed by LPyV VP1.	Hydrogen	14-22	VP1	Human polyomavirus 9	53-56
28602090-8	2017	This is the rate-determining step in the reaction cycle and is followed by hydrogen-atom transfer from the CE1-H group of trimethyl histidine substrate to iron(II)-superoxo.	Hydrogen	75-83	carboxylesterase 1	Homo sapiens	107-110
24652202-9	2014	Ligplot shows hydrogen bondings (S16, S17, V18, G19, K20, T21, S22, S31, T33, A35, S38, T39 and G65) and hydrophobic interacting residues (F25, F32, P34, F36, V37, D62 and A64) with the GTP ligands in the binding site of Rab3A protein.	Hydrogen	14-22	alpha and gamma adaptin binding protein	Homo sapiens	149-152
24912641-13	2014	Compared with sepsis group, the expression of HMGB1 was down-regulated significantly at 24 hours after CLP in hydrogen treatment group (1.147 +- 0.152 vs. 1.507 +- 0.220, t=2.805, P=0.023).	Hydrogen	110-118	high mobility group box 1	Mus musculus	46-51
24912641-15	2014	CONCLUSIONS: Through activation of Nrf2-antioxidant response element (ARE) pathway, hydrogen may increase the level of Nrf2, which is a kind of protective protein, in the intestine of mice, thus decreases the level of late pro-inflammatory factor, HMGB1, and it may protect the intestinal tissues in septic mice and increase the survival rate significantly.	Hydrogen	84-92	high mobility group box 1	Mus musculus	248-253
26714831-3	2016	The molecular docking studies were performed to elucidate the binding modes of the compounds with the target, and a crucial interaction involving hydrogen bond formation with Val-135 to the active site of GSK-3beta was observed.	Hydrogen	146-154	glycogen synthase kinase 3 beta	Homo sapiens	205-214
28266678-4	2017	Whilst not active for ammonia synthesis, the silicon nitride based materials were found to possess activity for the COx-free production of H2 from methane, which makes them candidates for applications in which the presence of low levels of CO in H2 feedstreams is detrimental.	Hydrogen	139-141	cytochrome c oxidase subunit 8A	Homo sapiens	116-119
24768637-4	2014	The structure reveals that the PDZ2-CXCR2 binding specificity is achieved by numerous hydrogen bonds and hydrophobic contacts with the last four CXCR2 residues contributing to specific interactions.	Hydrogen	86-94	C-X-C motif chemokine receptor 2	Homo sapiens	36-41
26878264-7	2016	Objectives Several potential hydrogen bonding partners of D666 and Y1792 across the A2-A3 interface were selected from the low-resolution FVIII crystal structure, and we used mutagenesis and biochemical analysis to examine the bonding interactions occurring at D666 and Y1792.	Hydrogen	29-37	coagulation factor VIII	Homo sapiens	138-143
28266678-4	2017	Whilst not active for ammonia synthesis, the silicon nitride based materials were found to possess activity for the COx-free production of H2 from methane, which makes them candidates for applications in which the presence of low levels of CO in H2 feedstreams is detrimental.	Hydrogen	246-248	cytochrome c oxidase subunit 8A	Homo sapiens	116-119
28650016-2	2017	In this work, we calculated 1H NMR chemical shifts of 1-ethyl-3-methylimidazolium (C2mim+) ionic liquids combined with various anions such as chloride (Cl), tetrafluoroborate (BF4), hexafluorophosphate (PF6), acetate (OAc), trifluoroacetate (TFA), and dicyanamide (DCA).	Hydrogen	28-30	sperm associated antigen 17	Homo sapiens	203-206
26983928-1	2016	A combined approach, using Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) and solid-state NMR (Nuclear Magnetic Resonance), shows a high degree of polymorphism exhibited by Abeta species in forming hydrogen-bonded networks.	Hydrogen	222-230	succinate-CoA ligase ADP-forming subunit beta	Homo sapiens	197-202
26983928-4	2016	Specifically, about one-third of the Abeta peptides were found to be involved in the formation of a specific >C (17)O   H-(15)N hydrogen bond with their neighbor peptide molecules, and we hypothesize that the rest of the molecules undergo +- n off-registry shifts in their hydrogen bonding networks.	Hydrogen	128-136	succinate-CoA ligase ADP-forming subunit beta	Homo sapiens	37-42
26983928-4	2016	Specifically, about one-third of the Abeta peptides were found to be involved in the formation of a specific >C (17)O   H-(15)N hydrogen bond with their neighbor peptide molecules, and we hypothesize that the rest of the molecules undergo +- n off-registry shifts in their hydrogen bonding networks.	Hydrogen	273-281	succinate-CoA ligase ADP-forming subunit beta	Homo sapiens	37-42
24687039-3	2014	Significantly, when secondary irradiation at 550 nm is introduced to simultaneously excite Au SPR, we observed 2.5 times higher activity for H2 generation.	Hydrogen	141-143	sepiapterin reductase	Homo sapiens	94-97
24631513-3	2014	In the current study, we found that the replacement of the 2-hydrogen atom (H) or N-methyl group (CH3) by the butyl group (C4C9) caused the more than 3-fold potent cytotoxic effects on cells transformed by the JAK2 V617F mutant.	Hydrogen	61-69	Janus kinase 2	Homo sapiens	210-214
28523734-4	2017	Such synergistic effects lead to superior HER catalytic activity with an overpotential of 152 mV versus reversible hydrogen electrode (RHE) for the electrocatalytic current density of j = -10 mA cm-2 , and a Tafel slope of 52 mV dec-1 .	Hydrogen	115-123	deleted in esophageal cancer 1	Homo sapiens	229-234
24390173-6	2014	HS produced concentration-dependent relaxation to non-selective adenosine analog, NECA in A(2A)AR+/+, whereas contraction was observed in A(2A)AR-/- mice and this was attenuated by A1AR antagonist (DPCPX).	Hydrogen	0-2	adenosine A1 receptor	Mus musculus	181-185
26777153-5	2016	RESULTS: After an ethyl-acetate group was introduced to the His(18) of hIAPP by diethylpyrocarbonate (DEPC) modification, the pH dependent hIAPP fibrillation went to the opposite order and the number of intra-molecular hydrogen bonds decreased, while the possibility of His(18) participating in the formation of alpha-helical structures increased.	Hydrogen	219-227	islet amyloid polypeptide	Homo sapiens	71-76
26777153-7	2016	CONCLUSIONS: The intramolecular hydrogen bond formation by His(18) and the possibility of His(18) participating in the formation of alpha-helical structures greatly modulated the manner of hIAPP amyloid formation.	Hydrogen	32-40	islet amyloid polypeptide	Homo sapiens	189-194
26286320-0	2016	1H, 13C and 15N resonance assignments of a C-terminal domain of human CHD1.	Hydrogen	0-2	chromodomain helicase DNA binding protein 1	Homo sapiens	70-74
28004495-5	2017	The origin of the N-methylated peptide inhibitor inhibiting IAPP aggregation is that it can keep good binding with IAPP template by stable hydrogen bonding interaction.	Hydrogen	139-147	islet amyloid polypeptide	Homo sapiens	60-64
24788925-2	2014	Here we show that a major structural solution for these HV1-69-sBnAbs is achieved through a critical triad comprising two CDR-H2 loop anchor residues (a hydrophobic residue at position 53 (Ile or Met) and Phe54), and CDR-H3-Tyr at positions 98+-1; together with distinctive V-segment CDR amino acid substitutions that occur in positions sparse in AID/polymerase-eta recognition motifs.	Hydrogen	126-128	hydrogen voltage gated channel 1	Homo sapiens	56-59
24788925-2	2014	Here we show that a major structural solution for these HV1-69-sBnAbs is achieved through a critical triad comprising two CDR-H2 loop anchor residues (a hydrophobic residue at position 53 (Ile or Met) and Phe54), and CDR-H3-Tyr at positions 98+-1; together with distinctive V-segment CDR amino acid substitutions that occur in positions sparse in AID/polymerase-eta recognition motifs.	Hydrogen	126-128	activation induced cytidine deaminase	Homo sapiens	347-350
28764534-3	2017	In our method, a glass flask acting as a dummy target is filled with liquid hydrogen (LH2) and is then irradiated with 2-mum light.	Hydrogen	76-84	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	86-89
24649965-4	2014	When a Pt nanoparticle is attached to the molecular wire by reductive cleavage of the disulfide and reaction with the resulting thiol, the PS I-NQ(CH2)15S-Pt nanoconstruct evolves dihydrogen at a rate of 67.3 mumol of H2 (mg of Chl)(-1) h(-1) [3.4 e(-) (PS I)(-1) s(-1)] after illumination for 1 h at pH 6.4.	Hydrogen	148-150	chordin like 1	Homo sapiens	228-231
26526668-4	2016	Based on differences between the Chlorella fusca FDX1 and C. reinhardtii FDX2 structures, we generated and purified point-mutated versions of the FDX2 protein and assayed them in vitro for their ability to catalyze hydrogen and NADPH photo-production.	Hydrogen	215-223	uncharacterized protein	Chlamydomonas reinhardtii	146-150
26808198-7	2016	Itk and Btk SH3 underwent a clear EX1 cooperative unfolding event, which was localized using pepsin digestion and mass spectrometry after hydrogen exchange labeling.	Hydrogen	138-146	FERM domain containing 6	Homo sapiens	34-37
28464408-3	2017	Our approach mimics the immunoglobulin-like domains of Titin, whose structure directs mechanical force towards the scission of sacrificial intramolecular hydrogen bonds, absorbing mechanical energy while unfolding.	Hydrogen	154-162	titin	Homo sapiens	55-60
27026206-8	2016	Over-expression of caspase-1 (the IL-1beta converting enzyme) and excessive reactive oxygen species (ROS) production in the hippocampus and prefrontal cortex (PFC) was successfully suppressed by hydrogen-rich water treatment.	Hydrogen	195-203	caspase 1	Mus musculus	19-28
27026206-8	2016	Over-expression of caspase-1 (the IL-1beta converting enzyme) and excessive reactive oxygen species (ROS) production in the hippocampus and prefrontal cortex (PFC) was successfully suppressed by hydrogen-rich water treatment.	Hydrogen	195-203	caspase 1	Mus musculus	34-60
24107872-2	2014	Compounds 13 and 14 lose H2 to give [1,3-mu-(H)-1,1-(PR3)2-3-(Py)-isonido-1,2-RhSB9H8](+), where PR3 = PMe2Ph (18), PPh3 and PMe2Ph (21), or PMePh2 (22).	Hydrogen	25-27	proteinase 3	Homo sapiens	53-56
24107872-2	2014	Compounds 13 and 14 lose H2 to give [1,3-mu-(H)-1,1-(PR3)2-3-(Py)-isonido-1,2-RhSB9H8](+), where PR3 = PMe2Ph (18), PPh3 and PMe2Ph (21), or PMePh2 (22).	Hydrogen	25-27	proteinase 3	Homo sapiens	97-100
28553742-5	2017	Regression analysis also showed that serum anti-RNase H2 levels were strongly correlated to that of CAF-1 in SLE patients.	Hydrogen	54-56	chromatin assembly factor 1 subunit A	Homo sapiens	100-105
24332566-8	2014	An 82% increase in NGF mRNA levels was detected after 1h of isoproterenol (beta-AR agonist) treatment, which increased an additional 22% at 24h.	Hydrogen	54-56	nerve growth factor	Rattus norvegicus	19-22
27011163-2	2016	The best operating conditions were preliminarily identified by testing different solvents and organic hydrogen donors in a batch hydrogenation process where micron-sized FAU seeds were employed as catalyst support.	Hydrogen	102-110	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	170-173
28387522-7	2017	Finally, differences in the hydrogen-bond pattern of the substrates were detected both in the CYP17A1-Cpd I and CYP17A1-POA complexes, with the former found to be more pivotal for the hydroxylation site than the latter, suggesting a possible explanation for the slower conversion of CYP17A1 for 17alpha-hydroxyprogesterone over 17alpha-hydroxypregnenolone.	Hydrogen	28-36	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	94-101
26929369-5	2016	Comparison between SRX and SFX structures revealed that photoreduction changes the coordination manner of the substrate and that catalytically important His255 can switch hydrogen bond partners between the backbone carbonyl oxygen of nearby Glu279 and the side-chain hydroxyl group of Thr280.	Hydrogen	171-179	sulfiredoxin 1	Homo sapiens	19-22
24491483-4	2014	The previous study generated a preliminary pharmacophore for the quercetin binding site on SIRT6, containing 3 hydrogen bond donors and one hydrogen bond acceptor.	Hydrogen	111-119	sirtuin 6	Homo sapiens	91-96
24491483-4	2014	The previous study generated a preliminary pharmacophore for the quercetin binding site on SIRT6, containing 3 hydrogen bond donors and one hydrogen bond acceptor.	Hydrogen	140-148	sirtuin 6	Homo sapiens	91-96
28387522-7	2017	Finally, differences in the hydrogen-bond pattern of the substrates were detected both in the CYP17A1-Cpd I and CYP17A1-POA complexes, with the former found to be more pivotal for the hydroxylation site than the latter, suggesting a possible explanation for the slower conversion of CYP17A1 for 17alpha-hydroxyprogesterone over 17alpha-hydroxypregnenolone.	Hydrogen	28-36	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	112-119
26910206-4	2016	The reduction process was carried out by TGA under 10% H2 diluted in argon, and its kinetics is analyzed and modeled.	Hydrogen	55-57	T-box transcription factor 1	Homo sapiens	41-44
24493739-4	2014	Using hydrogen/deuterium exchange coupled to mass spectrometry (H/DX-MS), we elucidate the concerted binding-folding of DAXX with histone variants H3.3/H4 and H3.2/H4 and find that high local stability at the variant-specific recognition residues rationalizes its known selectivity for H3.3.	Hydrogen	6-14	death domain associated protein	Homo sapiens	120-124
28387522-7	2017	Finally, differences in the hydrogen-bond pattern of the substrates were detected both in the CYP17A1-Cpd I and CYP17A1-POA complexes, with the former found to be more pivotal for the hydroxylation site than the latter, suggesting a possible explanation for the slower conversion of CYP17A1 for 17alpha-hydroxyprogesterone over 17alpha-hydroxypregnenolone.	Hydrogen	28-36	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	112-119
28369637-4	2017	This method compares pairwise the 2D 15N-1H NMR spectra of APOBEC3A bearing a deactivating mutation E72A in the presence of 36 slightly different DNA substrates.	Hydrogen	41-43	apolipoprotein B mRNA editing enzyme catalytic subunit 3A	Homo sapiens	59-67
26755752-4	2016	The more important aspects investigated pertain to the visible-light-induced generation of hydrogen by using semiconductor heterostructures of the type ZnO/Pt/Cd1-xZnxS and dye-sensitized semiconductors.	Hydrogen	91-99	CD1c molecule	Homo sapiens	159-162
28426082-0	2017	Deciphering of interactions between platinated DNA and HMGB1 by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	64-72	high mobility group box 1	Homo sapiens	55-60
28426082-3	2017	In the present work, we described a hydrogen/deuterium exchange mass spectrometry (HDX-MS) method in combination with docking simulation to decipher the interactions of platinated DNA with domain A of HMGB1.	Hydrogen	36-44	high mobility group box 1	Homo sapiens	201-206
26823274-2	2016	The kinetic isotope effect k(CH3)/k(CT3) for methyl transfer within a cage with a short axial distance becomes less inverse for shorter equatorial C   O distances: a decrease of 0.5 A results in a 3 % increase at 298 K. Kinetic isotope effects in AdoMet-dependent methyltransferases may be m odulated by CH   O hydrogen bonding, and factors other than axial compression may contribute, at least partially, to recently reported isotope-effect variations for catechol-O-methyltransferase and its mutant structures.	Hydrogen	311-319	catechol-O-methyltransferase	Homo sapiens	457-485
28485395-3	2017	The hybrid nanostructures exhibit overpotentials of 70 mV for hydrogen evolution and 235 mV for oxygen evolution at 10 mA cm-2 with long-term stability, which have superior kinetics for hydrogen- and oxygen-evolution with Tafel slope values of 38.1 and 45.7 mV dec-1.	Hydrogen	62-70	deleted in esophageal cancer 1	Homo sapiens	261-266
26799843-5	2016	In accordance with previous experimental reports, our computational results suggest that TET2 can bind to different substrates with comparable binding affinities and the hydrogen abstraction step in the catalytic cycle acts as the rate-limiting step.	Hydrogen	170-178	tet methylcytosine dioxygenase 2	Homo sapiens	89-93
26806274-0	2016	Synthesis of MOF templated Cu/CuO@TiO2 nanocomposites for synergistic hydrogen production.	Hydrogen	70-78	lysine acetyltransferase 8	Homo sapiens	13-16
28485395-3	2017	The hybrid nanostructures exhibit overpotentials of 70 mV for hydrogen evolution and 235 mV for oxygen evolution at 10 mA cm-2 with long-term stability, which have superior kinetics for hydrogen- and oxygen-evolution with Tafel slope values of 38.1 and 45.7 mV dec-1.	Hydrogen	186-194	deleted in esophageal cancer 1	Homo sapiens	261-266
28406633-7	2017	In this work, we apply newly developed 1H-detected 15N-HSQC type experiments under moderate magic angle spinning speeds to detect the conformationally excited states of phospholamban (PLN), a single-pass cardiac membrane protein that regulates Ca2+ transport across sarcoplasmic reticulum membrane.	Hydrogen	39-41	phospholamban	Homo sapiens	184-187
26815407-1	2016	(GaN)1-x(ZnO)x solid-solution nanostructures with superior crystallinity, large surface areas and visible light absorption have been regarded as promising photocatalysts for overall water splitting to produce H2.	Hydrogen	209-211	gigaxonin	Homo sapiens	1-4
26815407-6	2016	The efficiency and versatility of our strategy in the band-gap and facet engineering of (GaN)1-x(ZnO)x solid-solution nanorods will enhance their promising photocatalytic utilizations like an overall water splitting for H2 production under visible-light irradiation.	Hydrogen	220-222	gigaxonin	Homo sapiens	89-92
28406633-10	2017	By hybridizing 1H detected solution and solid-state NMR techniques, it is possible to detect and resolve the amide resonances of the R state of PLN in liquid crystalline lipid bilayers.	Hydrogen	15-17	phospholamban	Homo sapiens	144-147
28414434-5	2017	Significantly, the weakened N-H bonds in (iPrPDI)Mo(NH3)2(eta2-C2H4) enabled hydrogen atom abstraction and synthesis of a terminal nitride from coordinated ammonia, a key step in NH3 oxidation.	Hydrogen	77-85	DNA polymerase iota	Homo sapiens	58-62
26762541-6	2016	This finding was confirmed by all-atom molecular dynamics simulations and detailed analysis revealed that the hydrogens of the methylene groups at C22, C23, and C24 are magnetically inequivalent.	Hydrogen	110-119	nucleolin	Homo sapiens	152-155
28327740-5	2017	Results show that the moderate stability of intramolecular hydrogen bonds between SER71 and THR120 allows the CC" loop to sample both the open and closed states in apo-PD-1.	Hydrogen	59-67	programmed cell death 1	Homo sapiens	168-172
26900446-0	2016	Deciphering the Mode of Action of the Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 by Hydrogen-Deuterium Exchange Mass Spectrometry.	Hydrogen	113-121	dermatan sulfate epimerase	Homo sapiens	81-109
26529665-0	2016	HYDROGEN-RICH MEDIUM AMELIORATES LIPOPOLYSACCHARIDE-INDUCED BARRIER DYSFUNCTION VIA RHOA-MDIA1 SIGNALING IN CACO-2 CELLS.	Hydrogen	0-8	diaphanous related formin 1	Mus musculus	89-94
26529665-11	2016	Moreover, H2 improved the down-regulated expression and redistribution of occludin and E-cadherin caused by LPS.	Hydrogen	10-12	occludin	Homo sapiens	74-82
26529665-14	2016	Furthermore, H2-rich medium increased mDia1 expression, and mDia1 knockdown abolished protections of H2 on barrier permeability.	Hydrogen	13-15	diaphanous related formin 1	Mus musculus	38-43
26529665-16	2016	These findings suggest that H2 improves LPS-induced hyperpermeability of the intestinal barrier and disruptions of TJ and AJ by moderating RhoA-mDia1 signaling.	Hydrogen	28-30	diaphanous related formin 1	Mus musculus	144-149
28496315-9	2017	RESULTS: The results showed that hydrogen inhalation significantly reduced the number of inflammatory cells in the bronchoalveolar lavage fluid, and the mRNA and protein expression levels of tumor necrosis factor alpha, IL-6, IL-17, IL-23, matrix metalloproteinase-12, caspase-3, and caspase-8, but increased the tissue inhibitor of metalloproteinase-1 expression.	Hydrogen	33-41	matrix metallopeptidase 12	Rattus norvegicus	240-267
26653077-1	2016	Recently we presented structure-reactivity correlations for the gas-phase ambient-temperature rate constants for hydrogen abstraction from sp(3)-hybridized carbon by chlorine atom and hydroxyl radical (Cl /HO  + HCR3   HCl/HOH +  CR3); the reaction enthalpy effect was represented by the independent variable DeltarH and the "polar effect" by the independent variables F and R, the Hammett constants for field/inductive and resonance effects.	Hydrogen	113-121	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	213-216
28496315-9	2017	RESULTS: The results showed that hydrogen inhalation significantly reduced the number of inflammatory cells in the bronchoalveolar lavage fluid, and the mRNA and protein expression levels of tumor necrosis factor alpha, IL-6, IL-17, IL-23, matrix metalloproteinase-12, caspase-3, and caspase-8, but increased the tissue inhibitor of metalloproteinase-1 expression.	Hydrogen	33-41	caspase 3	Rattus norvegicus	269-278
28430238-2	2017	The hydrogen-environment thermal etching performed well in undercutting the AlGaN microdisks owing to the selective etching for the GaN layer.	Hydrogen	4-12	gigaxonin	Homo sapiens	78-81
26600404-8	2016	Strong hydrogen bonds between (alpha1 + alpha2) and alpha3 differ between SC1 and SC2 but are nearly invariant within each SC.	Hydrogen	7-15	transcription factor 19	Homo sapiens	74-77
28232482-3	2017	In aspartate aminotransferase (AAT), an extended hydrogen bond network is coupled to the pyridinyl nitrogen of the PLP, influencing the electrophilicity of the cofactor.	Hydrogen	49-57	pyridoxal phosphatase	Homo sapiens	115-118
26515654-2	2016	CS is caused by mutations in the SLC9A6 gene, which encodes a multipass transmembrane sodium (potassium)-hydrogen exchanger 6 (NHE6) protein, functional in early recycling endosomes.	Hydrogen	105-113	solute carrier family 9 (sodium/hydrogen exchanger), member 6	Mus musculus	33-39
26515654-2	2016	CS is caused by mutations in the SLC9A6 gene, which encodes a multipass transmembrane sodium (potassium)-hydrogen exchanger 6 (NHE6) protein, functional in early recycling endosomes.	Hydrogen	105-113	solute carrier family 9 (sodium/hydrogen exchanger), member 6	Mus musculus	127-131
26434626-0	2015	Analysis of distinct molecular assembly complexes of keratin K8 and K18 by hydrogen-deuterium exchange.	Hydrogen	75-83	keratin 18	Mus musculus	68-71
28232482-5	2017	We demonstrate that this hydrogen bond network directly influences the protonation state of the pyridine nitrogen of PLP, which affects the rates of catalysis.	Hydrogen	25-33	pyridoxal phosphatase	Homo sapiens	117-120
28232482-8	2017	Thus, PLP activation is controlled by the proximity of the pyridinyl nitrogen to the hydrogen bond microenvironment.	Hydrogen	85-93	pyridoxal phosphatase	Homo sapiens	6-9
27991832-1	2017	The phospho-transfer mechanism of yeast phosphoglycerate kinase (PGK) has been probed through formation of trifluoromagnesate (MgF3-) and tetrafluoroaluminate (AlF4-) transition state analogue complexes and analyzed using 19F, 1H waterLOGSY and 1H chemical shift perturbation NMR spectroscopy.	Hydrogen	227-229	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	40-63
26438213-7	2015	Activation of IRE1alpha RNase activity appears to be promoted by a network of hydrogen bond interactions between highly conserved residues across the RNase dimer interface that place key catalytic residues poised for reaction.	Hydrogen	78-86	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	14-23
26435515-5	2015	We also found that a strong YAP WW1 binder should have a negatively charged N-terminus, a positively charged C-terminus and a nonpolar core to match the electrostatic distribution pattern in peptide-binding pocket of YAP WW1 domain, which may also form additional nonbonded interactions such as hydrogen bond, salt bridge and pi-pi stacking to confer stability and specificity for the domain-peptide recognition.	Hydrogen	295-303	Yes1 associated transcriptional regulator	Homo sapiens	28-31
27991832-1	2017	The phospho-transfer mechanism of yeast phosphoglycerate kinase (PGK) has been probed through formation of trifluoromagnesate (MgF3-) and tetrafluoroaluminate (AlF4-) transition state analogue complexes and analyzed using 19F, 1H waterLOGSY and 1H chemical shift perturbation NMR spectroscopy.	Hydrogen	227-229	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	65-68
26435515-5	2015	We also found that a strong YAP WW1 binder should have a negatively charged N-terminus, a positively charged C-terminus and a nonpolar core to match the electrostatic distribution pattern in peptide-binding pocket of YAP WW1 domain, which may also form additional nonbonded interactions such as hydrogen bond, salt bridge and pi-pi stacking to confer stability and specificity for the domain-peptide recognition.	Hydrogen	295-303	Yes1 associated transcriptional regulator	Homo sapiens	217-220
27991832-1	2017	The phospho-transfer mechanism of yeast phosphoglycerate kinase (PGK) has been probed through formation of trifluoromagnesate (MgF3-) and tetrafluoroaluminate (AlF4-) transition state analogue complexes and analyzed using 19F, 1H waterLOGSY and 1H chemical shift perturbation NMR spectroscopy.	Hydrogen	245-247	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	40-63
27991832-1	2017	The phospho-transfer mechanism of yeast phosphoglycerate kinase (PGK) has been probed through formation of trifluoromagnesate (MgF3-) and tetrafluoroaluminate (AlF4-) transition state analogue complexes and analyzed using 19F, 1H waterLOGSY and 1H chemical shift perturbation NMR spectroscopy.	Hydrogen	245-247	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	65-68
28179147-5	2017	The structure reveals that the PDZ-CXCR2 binding specificity is achieved by numerous hydrogen bonds and hydrophobic contacts with the last four CXCR2 residues contributing to specific interactions.	Hydrogen	85-93	C-X-C motif chemokine receptor 2	Homo sapiens	35-40
26472372-2	2015	In particular, proton chemical shift anisotropy (CSA) has become an important tool for obtaining specific insights into inter/intra-molecular hydrogen bonding.	Hydrogen	142-150	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	49-52
26240146-4	2015	Here, we report a hydrogen/deuterium exchange and MS approach to investigate the effect of N-glycosylation on the binding of antibodies against different hCG glycoforms.	Hydrogen	18-26	chorionic gonadotropin subunit beta 5	Homo sapiens	154-157
26240146-8	2015	Hydrogen/deuterium exchange-MS reveals that the peptide beta65-83 of the hCG beta subunit is the epitope for MCA1024.	Hydrogen	0-8	chorionic gonadotropin subunit beta 5	Homo sapiens	73-76
28179147-5	2017	The structure reveals that the PDZ-CXCR2 binding specificity is achieved by numerous hydrogen bonds and hydrophobic contacts with the last four CXCR2 residues contributing to specific interactions.	Hydrogen	85-93	C-X-C motif chemokine receptor 2	Homo sapiens	144-149
27981425-0	2017	1H, 15N, 13C backbone resonance assignments of human soluble catechol O-methyltransferase in complex with S-adenosyl-L-methionine and 3,5-dinitrocatechol.	Hydrogen	0-2	catechol-O-methyltransferase	Homo sapiens	61-89
26166725-3	2015	Brain levels increased significantly within 1h following a single 50-mug dose of GDNF in a liposomal formulation, returning to baseline by 24h.	Hydrogen	44-46	glial cell derived neurotrophic factor	Rattus norvegicus	81-85
24624315-10	2014	Second, although the static co-crystal structure shows two large hydrogen-bonding networks in the GP1/hTfR1 interface, our simulations indicate that one of them may not be important for tight binding.	Hydrogen	65-73	transferrin receptor	Homo sapiens	102-107
27981425-4	2017	Here we report the backbone 1H, 15N and 13C chemical shift assignments of S-COMT in complex with S-adenosyl-L-methionine, 3,5-dinitrocatechol and Mg2+.	Hydrogen	28-30	catechol-O-methyltransferase	Homo sapiens	76-80
24753636-2	2014	As investigated by 1H NMR, the receptor forms both 1:1 and 1:2 complex yielding the binding constants of 2.32(3) (in log beta1 ) and 4.39(4) (in log beta2 ), respectively; where quinoline groups are protonated by the fluoride-induced proton transfer from the solution to the host molecule.	Hydrogen	19-21	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	149-154
28091961-0	2017	1H, 13C and 15N backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2.	Hydrogen	0-2	zinc finger protein 763	Homo sapiens	69-72
26025641-3	2015	Both smtB and mt2 mRNAs increased in the hepatic and brain tissues following 1h of cold stress, but only smtB exhibited a significant increase in the gills at 1 h and 6 h after transfer to 12  C. Furthermore, cellular apoptosis in the brain was not evident after cold shock, but liver and gills showed cellular apoptosis at 1-3 h, with another peak in the liver at 6 h after cold shock.	Hydrogen	77-79	metallothionein-B-like	Danio rerio	5-9
28147229-7	2017	Structural and thermodynamic characterization by native-state hydrogen-deuterium exchange mass spectrometry studies indicate that the precursor conformation is a partially unfolded form of PrP that forms under misfolding-prone solvent conditions.	Hydrogen	62-70	prion protein	Mus musculus	189-192
24200908-0	2014	A hydrogen bond network in the active site of Anabaena ferredoxin-NADP(+) reductase modulates its catalytic efficiency.	Hydrogen	2-10	ferredoxin reductase	Homo sapiens	55-83
28164863-3	2017	With the porous surface structure of FeP nanorods and the synergetic effect from the electronic conductive Ti support, this binder-free FeP electrode brings about a desirable electrocatalytic activity for the hydrogen evolution reaction (HER), showing a low onset overpotential of 23 mV and a small Tafel slope of 39 mV dec-1.	Hydrogen	209-217	deleted in esophageal cancer 1	Homo sapiens	320-325
24081608-2	2014	We found that these compounds adopt a scorpion-shaped conformation and they accept a hydrogen bond (HB) from the residue Val135 of the GSK3beta ATP-binding site hinge region.	Hydrogen	85-93	glycogen synthase kinase 3 beta	Homo sapiens	135-143
27485571-4	2014	As a result, a detailed map of the hydrogen bonds (HBs) and hydrophobic interactions between the T-loop residues of CDK2 and the residues of cycA that are different among nonphosphorylated and phosphorylated complexes were described.	Hydrogen	35-43	cyclin dependent kinase 2	Homo sapiens	116-120
28220917-2	2017	The X-ray structure of [CuL3(SO4)] shows that the sulfate anion is involved in cooperative binding via coordination to the metal ion and hydrogen-bonding to the urea unit.	Hydrogen	137-145	cullin 3	Homo sapiens	24-28
24593563-2	2014	A recent experiment in the NIFS-R&amp;D ion source has suggested that a "double ion plasma layer" which is a region consisting of hydrogen positive and negative ions exists near the plasma grid (PG).	Hydrogen	130-138	NFS1 cysteine desulfurase	Homo sapiens	27-31
28096195-9	2017	In addition, our findings demonstrate that MitEpac1 inhibits isocitrate dehydrogenase 2 via the mitochondrial recruitment of CaMKII (Ca2+/calmodulin-dependent protein kinase II), which decreases nicotinamide adenine dinucleotide phosphate hydrogen synthesis, thereby, reducing the antioxidant capabilities of the cardiomyocyte.	Hydrogen	74-82	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	125-131
24392950-0	2014	Structural diversity of copper(I) complexes formed by pyrrole- and dipyrrolylmethane-based diphosphine ligands with cu-X   HN hydrogen bonds.	Hydrogen	126-134	cut like homeobox 1	Homo sapiens	116-120
28096195-9	2017	In addition, our findings demonstrate that MitEpac1 inhibits isocitrate dehydrogenase 2 via the mitochondrial recruitment of CaMKII (Ca2+/calmodulin-dependent protein kinase II), which decreases nicotinamide adenine dinucleotide phosphate hydrogen synthesis, thereby, reducing the antioxidant capabilities of the cardiomyocyte.	Hydrogen	74-82	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	133-176
28111942-4	2017	It was demonstrated that the titanium-supported Ag NPs played an important role in motivating integrin alpha5 through triggering the galvanic hydrogen evolution reactions, which was found in positive correlation with the distribution density of the immobilized Ag NPs.	Hydrogen	142-150	integrin subunit alpha 5	Rattus norvegicus	94-109
24326302-10	2014	The movements of the hydrogen atoms during the hcp to intermediate phase transition are consistent with the result from the Raman spectra.	Hydrogen	21-29	alpha-1-microglobulin/bikunin precursor	Homo sapiens	47-50
24721310-12	2014	CONCLUSIONS: Hydrogen which may contribute to reduce rCklf1 expression prevents infiltration of inflammation and expression of MMP2 thus decreasing destruction and degradation of elastic fibers, therefore ameliorates development of AAA.	Hydrogen	13-21	matrix metallopeptidase 2	Rattus norvegicus	127-131
28055194-2	2017	This work presents an example of that adding nonredox metal ions as Lewis acid can enhance dioxygen activation by oxidovanadium(IV) complex, [VIV(O)Cl(TPA)]PF6 (where TPA is tris-[(2-pyridy)methyl]amine), which leads to efficient hydrogen abstraction at ambient temperature, whereas, in the absence of a Lewis acid, the catalytic hydrogen abstraction of the oxidovanadium(IV) complex is very sluggish.	Hydrogen	330-338	sperm associated antigen 17	Homo sapiens	156-159
28144570-1	2017	The aim of this research is to study the role of nanocrystalline TiO2/SnO2 n-n heterojunctions for hydrogen sensing.	Hydrogen	99-107	strawberry notch homolog 1	Homo sapiens	70-73
24967391-0	2014	Effects of exogenous lactase administration on hydrogen breath excretion and intestinal symptoms in patients presenting lactose malabsorption and intolerance.	Hydrogen	47-55	lactase	Homo sapiens	21-28
24967391-1	2014	OBJECTIVE: To establish whether supplementation with a standard oral dose of Beta-Galactosidase affects hydrogen breath excretion in patients presenting with lactose malabsorption.	Hydrogen	104-112	galactosidase beta 1	Homo sapiens	77-95
28144570-8	2017	The recovery time of SnO2-based heterostructures, despite their large responses over the whole measuring range, is much longer than that of TiO2-rich samples at higher H2 flows.	Hydrogen	168-170	strawberry notch homolog 1	Homo sapiens	21-24
27062905-5	2017	MAJOR CONCLUSIONS: Excessive nSMase activation by polyunsaturated fatty acids (PUFA), such as arachidonic acid (ARA) leads to disruption of the SM molecules and associated hydrogen bond network, with subsequent access of host antibodies and immune effectors to the outer membrane and eventual parasite death.	Hydrogen	172-180	sphingomyelin phosphodiesterase 2	Homo sapiens	29-35
24496246-10	2014	Transcript levels of IP3 receptor IP3R2 and of IP3R2 regulating transcription factor ETS1 were significantly higher in akt2(+/+) than in akt2(-/-) DCs prior to maturation and were upregulated by LPS stimulation (1h) in akt2(+/+) and to a lower extent in akt2(-/-) DCs.	Hydrogen	212-214	E26 avian leukemia oncogene 1, 5' domain	Mus musculus	85-89
27593109-9	2017	CONCLUSIONS: Our findings suggest that patients with LM and a serum DAO activity level&lt;10U/mL had higher end-expiratory H2 levels and tended to be more symptomatic during the LHBT compared to LM patients with DAO activity levels &gt;=10U/mL.	Hydrogen	123-125	amine oxidase copper containing 1	Homo sapiens	68-71
27756127-6	2016	When ions traveled through nanopores, Li+ had to overcome a greater energy barrier than Mg2+ because it had to shed more water molecules and break more hydrogen bonds in the second hydration shell compared with Mg2+.	Hydrogen	152-160	mucin 7, secreted	Homo sapiens	88-91
28060324-5	2016	For this reason, the rate-of-pressure rise (RoR) method is often used to measure the outgassing of hydrogen after bakeout.	Hydrogen	99-107	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	21-42
28060324-5	2016	For this reason, the rate-of-pressure rise (RoR) method is often used to measure the outgassing of hydrogen after bakeout.	Hydrogen	99-107	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	44-47
27793802-1	2016	The development of cystic fibrosis transmembrane conductance regulator (CFTR) targeted therapy for cystic fibrosis has generated interest in maximizing membrane residence of mutant forms of CFTR by manipulating interactions with scaffold proteins, such as sodium/hydrogen exchange regulatory factor-1 (NHERF1).	Hydrogen	263-271	CF transmembrane conductance regulator	Canis lupus familiaris	19-70
27793802-1	2016	The development of cystic fibrosis transmembrane conductance regulator (CFTR) targeted therapy for cystic fibrosis has generated interest in maximizing membrane residence of mutant forms of CFTR by manipulating interactions with scaffold proteins, such as sodium/hydrogen exchange regulatory factor-1 (NHERF1).	Hydrogen	263-271	CF transmembrane conductance regulator	Canis lupus familiaris	72-76
27634386-11	2016	Similarly, we saw a decrease in pS127-YAP and an increase in total YAP levels with short (1h) SPC treatment as well as a subsequent transient increase in YAP target gene expression.	Hydrogen	90-92	Yes1 associated transcriptional regulator	Homo sapiens	32-41
27634386-11	2016	Similarly, we saw a decrease in pS127-YAP and an increase in total YAP levels with short (1h) SPC treatment as well as a subsequent transient increase in YAP target gene expression.	Hydrogen	90-92	Yes1 associated transcriptional regulator	Homo sapiens	38-41
27634386-11	2016	Similarly, we saw a decrease in pS127-YAP and an increase in total YAP levels with short (1h) SPC treatment as well as a subsequent transient increase in YAP target gene expression.	Hydrogen	90-92	Yes1 associated transcriptional regulator	Homo sapiens	67-70
27908108-2	2016	For binary TrOH   FA adducts, the presence of dual hydrogen-bond linkages gives rise to three low-lying isomers designated (in relative energy order) as INT, EXT1, and EXT2 depending on whether docking of the FA ligand to the TrOH substrate takes place internal or external to the five-membered reaction cleft of tropolone.	Hydrogen	51-59	exostosin glycosyltransferase 1	Homo sapiens	158-162
27812562-5	2016	Importantly, heterodinuclear complex 3[PF6] and hydride bridged complex 4[BF4] can serve as effective catalysts to promote proton reduction for hydrogen evolution, as evidenced by cyclic voltammetry.	Hydrogen	144-152	sperm associated antigen 17	Homo sapiens	39-42
27704834-4	2016	The exchange of a 1,2-bis(dimethylsilyl)benzene ligand with ethylene and hydrogen gives a disilaferracycle bearing eta2-(CH2 CH2) and eta2-H2 ligands.	Hydrogen	73-81	DNA polymerase iota	Homo sapiens	115-119
26162428-5	2015	After fine mapping, a gene encoding a calcium(2+)/hydrogen(+) antiporter, cation/hydrogen(+) exchanger1 (CAX1), was identified as a candidate gene for the second QTL of Cd tolerance in A. halleri.	Hydrogen	50-58	cation exchanger 1	Arabidopsis thaliana	105-109
26162428-5	2015	After fine mapping, a gene encoding a calcium(2+)/hydrogen(+) antiporter, cation/hydrogen(+) exchanger1 (CAX1), was identified as a candidate gene for the second QTL of Cd tolerance in A. halleri.	Hydrogen	81-89	cation exchanger 1	Arabidopsis thaliana	105-109
27704834-4	2016	The exchange of a 1,2-bis(dimethylsilyl)benzene ligand with ethylene and hydrogen gives a disilaferracycle bearing eta2-(CH2 CH2) and eta2-H2 ligands.	Hydrogen	73-81	DNA polymerase iota	Homo sapiens	134-138
27796781-6	2016	Graphical Abstract Arachidonic acid docked in the active site of CYP2J2 assumes a catalytically competent binding mode stabilised by hydrogen bonds to Arg117.	Hydrogen	133-141	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	65-71
26327295-0	2015	Morpho-Functional 1H-MRI of the Lung in COPD: Short-Term Test-Retest Reliability.	Hydrogen	18-20	COPD	Homo sapiens	40-44
26327295-11	2015	CONCLUSION: Morpho-functional 1H-MRI can be obtained with reproducible image quality and high short-term test-retest reliability for COPD-related morphological and functional changes of the lung.	Hydrogen	30-32	COPD	Homo sapiens	133-137
26204267-9	2015	Moreover, we also established the active roles of base NEt3 in directing the heterolytic H2 splitting and assisting product release through the formation of an acid-base complex.	Hydrogen	89-91	tetraspanin 2	Homo sapiens	55-59
28246464-4	2016	Prevalence of literature study, we found that doxorubicin form strong hydrogen bond interactions with crystallized form of DDX3 using in-silico molecular docking approach.	Hydrogen	70-78	DEAD-box helicase 3 X-linked	Homo sapiens	123-127
26051108-14	2015	MD simulations revealed the binding modes of the 3 hit compounds: all of them showed a large number of hydrogen bonds and hydrophobic interactions with the active site and specificity pocket residues of AKR1B10.	Hydrogen	103-111	aldo-keto reductase family 1 member B10	Homo sapiens	203-210
27734966-6	2016	This high-resolution structure allows the accurate mapping of the interaction including water-mediated hydrogen bonds and provides, for the first time, a coherent explanation of PD-1 antagonism by pembrolizumab.	Hydrogen	103-111	programmed cell death 1	Homo sapiens	178-182
25681223-6	2015	But the secretion of hCG was both inhibited by 50-500 mumol/L molecular hydrogen and high levels of vitamin C and E, separately or combined.	Hydrogen	72-80	chorionic gonadotropin subunit beta 5	Homo sapiens	21-24
25681223-8	2015	Meanwhile hydrogen showed no such effects on cell proliferation and TNF-alpha expression, but it could affect the level of hCG, indicating hydrogen as a potential candidate of antioxidant in the management of preeclampsia (PE) should be further studied.	Hydrogen	10-18	chorionic gonadotropin subunit beta 5	Homo sapiens	123-126
25681223-8	2015	Meanwhile hydrogen showed no such effects on cell proliferation and TNF-alpha expression, but it could affect the level of hCG, indicating hydrogen as a potential candidate of antioxidant in the management of preeclampsia (PE) should be further studied.	Hydrogen	139-147	chorionic gonadotropin subunit beta 5	Homo sapiens	123-126
27541982-4	2016	As compared to its precursor, [C12mpip][AcSa] has low CAC values, indicating enhanced favorable interactions between the [alkylmpip]+ cation   bulky [AcSa]- anion and also hydrogen bonding of both of the ions with water.	Hydrogen	172-180	acyl-CoA synthetase short chain family member 2	Homo sapiens	40-44
25988615-5	2015	Molecular docking study of 37 showed binding with the amino acid residues of CYP17 through hydrogen bonds and hydrophobic interaction.	Hydrogen	91-99	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	77-82
27541982-4	2016	As compared to its precursor, [C12mpip][AcSa] has low CAC values, indicating enhanced favorable interactions between the [alkylmpip]+ cation   bulky [AcSa]- anion and also hydrogen bonding of both of the ions with water.	Hydrogen	172-180	acyl-CoA synthetase short chain family member 2	Homo sapiens	150-154
26227784-6	2015	Structure-activity relationship study proposed a binding mode for NAMPT inhibitor F671-0003 and highlighted the importance of hydrogen bonding, hydrophobic and pi-pi interactions in inhibitor binding.	Hydrogen	126-134	nicotinamide phosphoribosyltransferase	Homo sapiens	66-71
27386874-0	2016	Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-kappaB Expression.	Hydrogen	26-34	microRNA 210	Rattus norvegicus	139-146
26010059-1	2015	The transfer of photosynthetic electrons by the ferredoxin PetF to the [FeFe] hydrogenase HydA1 in the microalga Chlamydomonas reinhardtii is a key step in hydrogen production.	Hydrogen	78-86	uncharacterized protein	Chlamydomonas reinhardtii	48-58
25907510-4	2015	Results evidence that all blocks contribute similarly to the model; moreover, hydrogen bonding donor (HBD) properties of solutes favor the interaction with mucin; and thus, support their detrimental role on drug permeability.	Hydrogen	78-86	LOC100508689	Homo sapiens	156-161
25895145-11	2015	H2 therapy in the animals with severe sepsis was associated with reduced intestinal injury, decreased numbers of colony-forming unit and apoptotic cells, reduced levels of biochemical markers, oxidative products, and high-mobility group box 1 protein.	Hydrogen	0-2	high mobility group box 1	Mus musculus	217-242
27719669-12	2016	DEHP and each of its five metabolites formed a hydrogen bonding interaction with residue Gln-725 of PR.	Hydrogen	47-55	progesterone receptor	Homo sapiens	100-102
25988324-0	2015	Can a single water molecule really affect the HO2 + NO2 hydrogen abstraction reaction under tropospheric conditions?	Hydrogen	56-64	heme oxygenase 2	Homo sapiens	46-49
25988324-1	2015	The effect of a single water molecule on the HO2 + NO2 hydrogen abstraction reaction has been investigated by employing B3LYP and CCSD(T) theoretical approaches with the aug-cc-pVTZ basis set.	Hydrogen	55-63	heme oxygenase 2	Homo sapiens	45-48
27598838-0	2016	Bare Cd1-xZnxS ZB/WZ Heterophase Nanojunctions for Visible Light Photocatalytic Hydrogen Production with High Efficiency.	Hydrogen	80-88	CD1c molecule	Homo sapiens	5-8
25774984-8	2015	Hydrogen bonds are formed between the alpha1,6 branch and the backbone of Trp99 and Lys102 side chain of beta2-CBM.	Hydrogen	0-8	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	105-110
26120483-9	2015	RESULTS: Lawsone and THN can be considered to efficiently bind with NOS, CAT, GSH, GR, G6PDH and NADPH, which has been confirmed through hydrogen bond affinity with the respective amino acids.	Hydrogen	137-145	glutathione-disulfide reductase	Homo sapiens	83-85
25302382-2	2014	The process occurs via atomic hydrogen addition reactions leading to the formation of super-hydrogenated PAH species, followed by molecular hydrogen forming abstraction reactions.	Hydrogen	30-38	phenylalanine hydroxylase	Homo sapiens	105-108
25302382-2	2014	The process occurs via atomic hydrogen addition reactions leading to the formation of super-hydrogenated PAH species, followed by molecular hydrogen forming abstraction reactions.	Hydrogen	92-100	phenylalanine hydroxylase	Homo sapiens	105-108
24862279-6	2014	In addition, hypoxia induces (1) the HIF-1-dependent expression of BCL2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) and BNIP3-like (BNIP3L), which trigger mitochondrial autophagy, thereby decreasing the oxidative metabolism of both fatty acids and glucose, and (2) the expression of the sodium-hydrogen exchanger NHE1, which maintains an alkaline intracellular pH.	Hydrogen	302-310	BCL2 interacting protein 3 like	Homo sapiens	128-138
24862279-6	2014	In addition, hypoxia induces (1) the HIF-1-dependent expression of BCL2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) and BNIP3-like (BNIP3L), which trigger mitochondrial autophagy, thereby decreasing the oxidative metabolism of both fatty acids and glucose, and (2) the expression of the sodium-hydrogen exchanger NHE1, which maintains an alkaline intracellular pH.	Hydrogen	302-310	BCL2 interacting protein 3 like	Homo sapiens	140-146
27598838-8	2016	Our results demonstrate that Cd1-xZnxS ZB/WZ heterophase junctions stabilized by l-cysteine molecules can effectively separate charge carriers and achieve highly visible light photocatalytic hydrogen production.	Hydrogen	191-199	CD1c molecule	Homo sapiens	29-32
27436807-5	2016	These studies provided the binding model where the carbonyl group at position 27, the hydroxyl group at position 30, and the phenolic hydroxyl group at position 20 of ATX were involved in intermolecular hydrogen bonding with the PKCdelta C1B domain, which would be useful for the rational design of ATX derivatives as anticancer lead compounds.	Hydrogen	203-211	protein kinase C delta	Homo sapiens	229-237
24477114-4	2014	We observe substantial and differential effects upon amide-to-ester mutation in PDZ2 of postsynaptic density protein 95 and other PDZ domains, suggesting that hydrogen bonding at the carboxylate-binding site contributes to both affinity and selectivity.	Hydrogen	159-167	discs large MAGUK scaffold protein 4	Homo sapiens	88-119
26199614-5	2015	Results at 24 hours, 48 hours, 1 week and 2 weeks after injury showed that hydrogen-rich saline markedly reduced cell death, inflammatory cell infiltration, serum malondialdehyde content, and caspase-3 immunoreactivity, elevated serum superoxide dismutase activity and calcitonin gene-related peptide immunoreactivity, and improved motor function in the hindlimb.	Hydrogen	75-83	caspase 3	Rattus norvegicus	192-201
27402847-8	2016	The data generated in this study are combined to input constraints for a molecular model of the Hsp90/Tom70 interaction, which has been validated by small angle x-ray scattering, hydrogen/deuterium exchange, and mass spectrometry.	Hydrogen	179-187	translocase of outer mitochondrial membrane 70	Homo sapiens	102-107
25862210-4	2015	Based on the binding mode, N-ethylmethylamine was identified as a promising scaffold that forms hydrogen bonds with the catalytic residues of sEH, Asp335, Tyr383, and Tyr466.	Hydrogen	96-104	epoxide hydrolase 2	Homo sapiens	142-145
24175616-2	2013	This work details an ab initio and chemical kinetic study of the hydrogen atom abstraction reactions by the hydroperoxyl radical (HO2) on the following esters: methyl ethanoate, methyl propanoate, methyl butanoate, methyl pentanoate, methyl isobutyrate, ethyl ethanoate, propyl ethanoate, and isopropyl ethanoate.	Hydrogen	65-73	heme oxygenase 2	Homo sapiens	130-133
26457828-6	2016	The unfolded state of mutant structure established more number of inter-molecular hydrogen bonding interaction at interface level due to the conformational variability, thus mediated high binding affinity with its interacting partner, Cdc42.	Hydrogen	82-90	cell division cycle 42	Homo sapiens	235-240
24076403-2	2013	Analysis of the intact enzyme with hydrogen/deuterium exchange mass spectrometry reveals conformational perturbations of AMPK in response to binding of nucleotides, cyclodextrin, and a synthetic small molecule activator, A769662.	Hydrogen	35-43	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	121-125
25954931-11	2015	Ussing chamber studies revealed increase in 3H-5-HT uptake in mouse ileum treated ex vivo with TGF-beta1 (10 ng/ml, 1h).	Hydrogen	116-118	transforming growth factor, beta 1	Mus musculus	95-104
27450300-5	2016	Moreover the acidic hydrogens in CuL(1) increase its cytotoxicity much more than methyl substitution as in CuL(3).	Hydrogen	20-29	cullin 1	Homo sapiens	33-39
25711379-4	2015	Many of the predicted hydrogen bonds were present in less than 50% of the simulation; however, persistent hydrogen bonds between G5/15 and the formamido group of f-ImPyIm were observed.	Hydrogen	106-114	G-patch domain and ankyrin repeats 1	Homo sapiens	129-134
23864610-0	2013	Transport of H2S and HS(-) across the human red blood cell membrane: rapid H2S diffusion and AE1-mediated Cl(-)/HS(-) exchange.	Hydrogen	21-23	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	93-96
27072779-5	2016	Our MD simulation suggested that the beta2-dimer is potentially stable and remains relatively close to its initial conformation due to the presence of a number of hydrogen bonds, ionic salt bridges, and other favorable interactions.	Hydrogen	163-171	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	37-42
24099939-3	2013	EA and TGA-MS results showed that the hydrogen content decreased continuously and the oxygen content increased up to 260  C then decreased and the carbon content increased passively during thermostabilization.	Hydrogen	38-46	T-box transcription factor 1	Homo sapiens	7-10
25060390-6	2015	A ground state complex was formed by hydrogen bonding between the carboxyl group of CuInS2 /ZnS/TGA QDs and the amino group of TKI.	Hydrogen	37-45	T-box transcription factor 1	Homo sapiens	96-99
27560716-6	2016	We have also demonstrated the presence of H2 and LeY antigens on LAMP-1 by a targeted nanoLC-MS(3) and the decreased levels of fucosylation on LAMP-2 by MALDI-TOF analysis upon FUT1 knockdown.	Hydrogen	42-44	lysosomal associated membrane protein 1	Homo sapiens	65-71
25419488-3	2013	Here, RNP-4F is believed to initially bind to a recognition sequence on U6-snRNA, serving as a chaperone to facilitate its association with U4-snRNA by intermolecular hydrogen bonding.	Hydrogen	167-175	RNA-binding protein 4F	Drosophila melanogaster	6-12
27558766-0	2016	Red Mud as an Efficient, Stable, and Cost-Free Catalyst for COx-Free Hydrogen Production from Ammonia.	Hydrogen	69-77	cytochrome c oxidase subunit 8A	Homo sapiens	60-63
23886934-10	2013	This result in conjugation with the molecular modeling revealed the crucial role of hydrogen-bonding interaction of Asn228 on CYP1B1.1 with the methoxy moiety of berberine.	Hydrogen	84-92	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	126-132
27558766-3	2016	For instance, stable hydrogen production rates were measured as 72 and 196 mmol H2 min(-1) gcat(-1) for the corresponding space velocities of 72 000 and 240 000 cm(3) NH3 h(-1) gcat(-1), respectively, at 700  C. These results offer opportunities to utilize one of the key hazardous industrial wastes as an eco-friendly, efficient, stable, and almost cost-free catalyst for COx-free hydrogen production from ammonia decomposition.	Hydrogen	21-29	cytochrome c oxidase subunit 8A	Homo sapiens	373-376
27558766-3	2016	For instance, stable hydrogen production rates were measured as 72 and 196 mmol H2 min(-1) gcat(-1) for the corresponding space velocities of 72 000 and 240 000 cm(3) NH3 h(-1) gcat(-1), respectively, at 700  C. These results offer opportunities to utilize one of the key hazardous industrial wastes as an eco-friendly, efficient, stable, and almost cost-free catalyst for COx-free hydrogen production from ammonia decomposition.	Hydrogen	80-82	cytochrome c oxidase subunit 8A	Homo sapiens	373-376
24030544-6	2013	These comparative studies show that Cat4, although based on a noble metal, is about four times less active, while Cat2 and Cat3 produce more than one hundred times less hydrogen than Cat1.	Hydrogen	169-177	solute carrier family 7 member 4	Homo sapiens	36-40
24030544-6	2013	These comparative studies show that Cat4, although based on a noble metal, is about four times less active, while Cat2 and Cat3 produce more than one hundred times less hydrogen than Cat1.	Hydrogen	169-177	solute carrier family 7 member 2	Homo sapiens	114-118
27406796-4	2016	The molecular docking studies revealed multiple hydrogen bond interactions by the synthesized compounds with various amino acid residues, viz, ASP-133, LYS-183, PRO-136, VAL-135, TYR-134, or LYS-60 at the GSK-3beta receptor site.	Hydrogen	48-56	glycogen synthase kinase 3 beta	Homo sapiens	205-214
23995840-4	2013	Hydrogen-deuterium exchange coupled with mass spectrometry confirmed the highly dynamic intrinsically disordered property of the NTD within the context of full-length PR.	Hydrogen	0-8	progesterone receptor	Homo sapiens	167-169
23996000-1	2013	X-ray structural and mutational analyses have shown that bovine heart cytochrome c oxidase (CcO) pumps protons electrostatically through a hydrogen bond network using net positive charges created upon oxidation of a heme iron (located near the hydrogen bond network) for O2 reduction.	Hydrogen	139-147	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	70-90
23996000-1	2013	X-ray structural and mutational analyses have shown that bovine heart cytochrome c oxidase (CcO) pumps protons electrostatically through a hydrogen bond network using net positive charges created upon oxidation of a heme iron (located near the hydrogen bond network) for O2 reduction.	Hydrogen	139-147	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	92-95
27525951-8	2016	The glycopentalone was well mapped to CDK-2 and VEGFR-2 which involve six pharmacophore features (two hydrophobic centers and four hydrogen bond acceptors) and nine pharmacophore features (five hydrophobic, two hydrogen bond acceptors and two hydrogen bond donors), respectively.	Hydrogen	131-139	cyclin dependent kinase 2	Homo sapiens	38-43
24009077-3	2013	To unambiguously identify the apparent "hot spot" on FVIII to which this antibody binds, we have employed hydrogen-deuterium exchange mass spectrometry.	Hydrogen	106-114	coagulation factor VIII	Homo sapiens	53-58
24009077-4	2013	The results showed that KM33 protects FVIII regions 2091-2104 and 2157-2162 from hydrogen-deuterium exchange.	Hydrogen	81-89	coagulation factor VIII	Homo sapiens	38-43
27525951-8	2016	The glycopentalone was well mapped to CDK-2 and VEGFR-2 which involve six pharmacophore features (two hydrophobic centers and four hydrogen bond acceptors) and nine pharmacophore features (five hydrophobic, two hydrogen bond acceptors and two hydrogen bond donors), respectively.	Hydrogen	211-219	cyclin dependent kinase 2	Homo sapiens	38-43
27525951-8	2016	The glycopentalone was well mapped to CDK-2 and VEGFR-2 which involve six pharmacophore features (two hydrophobic centers and four hydrogen bond acceptors) and nine pharmacophore features (five hydrophobic, two hydrogen bond acceptors and two hydrogen bond donors), respectively.	Hydrogen	211-219	cyclin dependent kinase 2	Homo sapiens	38-43
27472896-2	2016	The pre-catalyst [Ir(cod)(kappaP,C,P"-NHO(PPh2))]PF6 has shown excellent activities in the transfer hydrogenation of aldehydes, ketones and imines using (i)PrOH as a hydrogen source, while [IrCl(cod)(kappaC-NHO(OMe))] decomposes throughout the reaction to give low yields of the hydrogenated product.	Hydrogen	100-108	sperm associated antigen 17	Homo sapiens	49-52
24132903-6	2013	We use this approach to determine if prior data implicating the sodium/hydrogen exchanger 9 gene (SLC9A9) in ADHD implicate sodium/hydrogen exchange (NHE) inhibitors as potential treatments.	Hydrogen	71-79	solute carrier family 9 member C1	Homo sapiens	150-153
27490527-10	2016	It revealed that CA might downregulate the PPAR-gamma2 expression by directly binding with amino acids of PPAR-gamma2 by hydrogen at 3.26 distance and hydrophobic interactions at 3.90 contact distances.	Hydrogen	121-129	peroxisome proliferator activated receptor gamma	Mus musculus	43-54
24392614-9	2013	RESULTS: Heritability of renal function biomarkers ranged from .19-.32 (all P &lt; .001), and was highest for cystatin C (h2 = .32, P &lt; .0001).	Hydrogen	122-124	cystatin C	Homo sapiens	110-120
27490527-10	2016	It revealed that CA might downregulate the PPAR-gamma2 expression by directly binding with amino acids of PPAR-gamma2 by hydrogen at 3.26 distance and hydrophobic interactions at 3.90 contact distances.	Hydrogen	121-129	peroxisome proliferator activated receptor gamma	Mus musculus	106-117
27271261-4	2016	Graphical abstract Glucose-phosphate sugars (Glc-1P and Glc-6P) detected in muscle by 1H HR-MAS NMR.	Hydrogen	86-88	GLC1P	Homo sapiens	45-51
23806658-4	2013	IRP1/IRE binding occurs through two separate interfaces, which together contribute about two-dozen hydrogen bonds.	Hydrogen	99-107	aconitase 1	Homo sapiens	0-4
23800761-0	2013	Mobility on the reconstructed Pt(100)-hex surface in ethylene and in its mixture with hydrogen and carbon monoxide.	Hydrogen	86-94	hematopoietically expressed homeobox	Homo sapiens	38-41
27374698-6	2016	The results obtained provide experimental support for the strength of hydrogen bonds between the alcohols and the NTf2 and PF6 anions, providing insights into the IL intermolecular interactions, namely by indicating the ability of the alcohols to discriminate the IL anion hydrogen bond basicity.	Hydrogen	70-78	sperm associated antigen 17	Homo sapiens	123-126
27443692-6	2016	As a result, the optimal solar-to-hydrogen efficiency of ZnO/Au/Al2O3 with 5 cycles was 6.7 times that of pristine ZnO, ascribed to the synergistic effect of SPR and surface passivation.	Hydrogen	34-42	sepiapterin reductase	Homo sapiens	158-161
23843363-4	2013	Herein, a series of homoleptic tris-cyclometalated iridium complexes, based on different 2-phenylpyridine ligands, were utilized as PSs in photocatalytic systems for hydrogen production with [Rh(dtb-bpy)3 ](PF6 )3 (dtb-bpy=4,4"-di-tert-butyl-2,2"-dipyridyl) serving as the water reduction catalyst (WRC) and triethanolamine (TEOA) as the electron donor.	Hydrogen	166-174	sperm associated antigen 17	Homo sapiens	207-210
27385829-5	2016	We used hydrogen-deuterium exchange coupled to mass spectrometry and negative-stain electron microscopy to map NRBF2 to the base of the V-shaped complex.	Hydrogen	8-16	nuclear receptor binding factor 2	Homo sapiens	111-116
23740770-5	2013	Our results show that sulfation stabilizes the dimeric state of the CXCR4:SDF-1 complex through hydrogen bonding across the dimer interface, conformational changes in residues at the dimer interface, and an enhancement in electrostatic binding energies associated with dimerization.	Hydrogen	96-104	C-X-C motif chemokine ligand 12	Homo sapiens	74-79
23883429-2	2013	In this work, highly efficient three-dimensional (3D) Cd1-xZnxS photocatalysts for hydrogen generation under the irradiation of visible light were synthesized via one-step solvothermal pathway.	Hydrogen	83-91	CD1c molecule	Homo sapiens	54-57
27128573-11	2016	In a mice proof-of-principle study, cryab-20-peptide was synthesized and administered 1h before LAD-ligation and ECG-proven MI.	Hydrogen	86-88	crystallin, alpha B	Mus musculus	36-41
23713783-7	2013	Results of the theoretically calculated rate coefficients indicate that the hydrogen abstraction by HO2 from the C2 carbon of both MTHF and DMTHF is the most dominant path among all reaction pathways attributed to its lowest barrier height.	Hydrogen	76-84	heme oxygenase 2	Homo sapiens	100-103
23785468-5	2013	Among the interface mutations studied, those located in the cluster of hydrophobic contacts at NTD-NTD interface and those that disrupted NTD-CTD inter-domain helix capping hydrogen bonds were the most detrimental, indicating that these interactions are particularly important for maintaining capsid structure and/or function.	Hydrogen	173-181	fuzzy planar cell polarity protein	Homo sapiens	95-98
23785468-5	2013	Among the interface mutations studied, those located in the cluster of hydrophobic contacts at NTD-NTD interface and those that disrupted NTD-CTD inter-domain helix capping hydrogen bonds were the most detrimental, indicating that these interactions are particularly important for maintaining capsid structure and/or function.	Hydrogen	173-181	fuzzy planar cell polarity protein	Homo sapiens	99-102
23785468-5	2013	Among the interface mutations studied, those located in the cluster of hydrophobic contacts at NTD-NTD interface and those that disrupted NTD-CTD inter-domain helix capping hydrogen bonds were the most detrimental, indicating that these interactions are particularly important for maintaining capsid structure and/or function.	Hydrogen	173-181	fuzzy planar cell polarity protein	Homo sapiens	99-102
27254650-1	2016	In this article, the reaction mechanisms of H2S + (3)O2 formation by the HO2 + HS reaction without and with catalyst X (X = H2O, (H2O)2 and (H2O)3) have been investigated theoretically at the CCSD(T)/6-311++G(3df,2pd)//B3LYP/6-311+G(2df,2p) level of theory, coupled with rate constant calculations by using conventional transition state theory.	Hydrogen	79-81	heme oxygenase 2	Homo sapiens	73-76
27225027-0	2016	Fabrication of COF-MOF Composite Membranes and Their Highly Selective Separation of H2/CO2.	Hydrogen	84-86	lysine acetyltransferase 8	Homo sapiens	19-22
23590552-2	2013	This work presents an ab initio and chemical kinetic study of the reaction mechanisms of hydrogen atom abstraction by the HO2 radical on five ketones: dimethyl, ethyl methyl, n-propyl methyl, iso-propyl methyl, and iso-butyl methyl ketones.	Hydrogen	89-97	heme oxygenase 2	Homo sapiens	122-125
27225027-3	2016	The resultant COF-MOF composite membranes demonstrate higher separation selectivity of H2/CO2 gas mixtures than the individual COF and MOF membranes.	Hydrogen	87-89	lysine acetyltransferase 8	Homo sapiens	18-21
27225027-4	2016	A sound proof for the synergy between two porous materials is the fact that the COF-MOF composite membranes surpass the Robeson upper bound of polymer membranes for mixture separation of a H2/CO2 gas pair and are among the best gas separation MOF membranes reported thus far.	Hydrogen	189-191	lysine acetyltransferase 8	Homo sapiens	84-87
25865253-0	2015	Hydration and Hydrogen Bond Network of Water during the Coil-to-Globule Transition in Poly(N-isopropylacrylamide) Aqueous Solution at Cloud Point Temperature.	Hydrogen	14-22	coilin	Homo sapiens	56-60
27090615-4	2016	CDK2 X-ray cocrystal structures have revealed a DFG-loop adaption for the 5-(trifluoromethyl) substituent, while for hydrogen and bromo substituents the DFG loop remains in its characteristic type I inhibitor position.	Hydrogen	117-125	cyclin dependent kinase 2	Homo sapiens	0-4
23685943-5	2013	Docking analysis of 53S using our hTRPV1 homology model indicated that the A- and B-region 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamide made important hydrophobic and hydrogen bonding interactions with Tyr511 and that the C-region 6-trifluoromethyl and 2-benzyloxy groups of pyridine occupied the two hydrophobic binding pockets, respectively.	Hydrogen	174-182	transient receptor potential cation channel subfamily V member 1	Homo sapiens	34-40
27105921-1	2016	An actinyl peroxide cage cluster, Li48+m K12 (OH)m [UO2 (O2 )(OH)]60 (H2 O)n (m 20 and n 310; U60 ), discriminates precisely between Na(+) and K(+) ions when heated to certain temperatures, a most essential feature for K(+) selective filters.	Hydrogen	70-72	small nucleolar RNA, C/D box 60	Homo sapiens	94-97
23745864-3	2013	The hydrogen atom is unique, since it only has one electron and, in a dc electric field, the Stark Hamiltonian is exactly separable in terms of parabolic coordinates (eta, xi, phi).	Hydrogen	4-12	endothelin receptor type A	Homo sapiens	167-170
25835183-4	2015	In light of the reactivity of metal-coordinated thiolates to ROS, several hypotheses have been proffered and include the coordination of His1-Ndelta to the Ni(II) and Ni(III) forms of NiSOD, as well as hydrogen bonding or full protonation of a coordinated S(Cys).	Hydrogen	202-210	viral integration site 1	Homo sapiens	137-141
25807267-7	2015	During MD, NTSR1-GW5 becomes more hydrated compared to wild type NTSR1, with tight hydrogen bonded water clusters within the transmembrane core of the receptor, thus providing evidence that water plays an important role in improving helical packing in the thermostable mutant.	Hydrogen	83-91	neurotensin receptor 1	Homo sapiens	11-16
23535462-8	2013	The mice exhibited significant blood pressure increases during the awake phase (night) that were larger in COX-2(-/-) on HS diet compared with COX-2(+/+).	Hydrogen	121-123	prostaglandin-endoperoxide synthase 2	Mus musculus	107-112
27279733-6	2016	It appears that the destabilized subpopulation of CP47 complexes could feature a weakened hydrogen bond between the 13(1)-keto group of Chl29 and the PsbH protein subunit, though other possibilities cannot be entirely excluded, as discussed in this work.	Hydrogen	90-98	photosystem II reaction center protein H	Spinacia oleracea	150-154
23535462-9	2013	Water intake, diuresis, Na(+), and osmolyte excretions and NOx and cGMP excretions were significantly and similarly elevated with HS in COX-2(-/-) and COX-2(+/+).	Hydrogen	130-132	prostaglandin-endoperoxide synthase 2	Mus musculus	136-141
23535462-9	2013	Water intake, diuresis, Na(+), and osmolyte excretions and NOx and cGMP excretions were significantly and similarly elevated with HS in COX-2(-/-) and COX-2(+/+).	Hydrogen	130-132	prostaglandin-endoperoxide synthase 2	Mus musculus	151-156
26784277-11	2016	CCR2 expression on CD14 monocytes was significantly lower at IP, 1H, 2H, and 5H (P values &lt; 0.05).	Hydrogen	65-67	CD14 molecule	Homo sapiens	19-23
27056331-4	2016	Here we identified this allosteric site for efavirenz on CYP46A1 by using a combination of hydrogen-deuterium exchange coupled to MS, computational modeling, site-directed mutagenesis, and analysis of the CYP46A1 crystal structure.	Hydrogen	91-99	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	57-64
23795064-2	2013	The mol-ecular structure of each zwitterion is stabilized by an intra-molecular six-membered (C 6 ) N-H O hydrogen bond.	Hydrogen	106-114	complement C6	Homo sapiens	94-97
23541574-9	2013	The 1h cyclic stretching protocol acutely increased the phosphorylation of Akt (+4.5-fold; P&lt;0.05) and its downstream targets, FOXO3a (+4.2-fold; P&lt;0.05) and GSK-3beta (+1.8-fold; P&lt;0.05), which returned to baseline by 48 h after cessation of stretch.	Hydrogen	4-6	glycogen synthase kinase 3 beta	Homo sapiens	164-173
27164019-0	2016	Theoretical Prediction of Rate Constants for Hydrogen Abstraction by OH, H, O, CH3, and HO2 Radicals from Toluene.	Hydrogen	45-53	heme oxygenase 2	Homo sapiens	88-91
23458502-2	2013	In the present study, we evaluated the possible involvement of COX-2-related signaling in the activation of the hypothalamic-pituitary-adrenal (HPA) axis under three different stress conditions, namely infectious (lipopolysaccharide, LPS), hypoglycemic (2-deoxy-d-glucose, 2DG) and restraint (1h) stresses in rats.	Hydrogen	293-295	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	63-68
23613840-0	2013	RNAi knock-down of LHCBM1, 2 and 3 increases photosynthetic H2 production efficiency of the green alga Chlamydomonas reinhardtii.	Hydrogen	60-62	uncharacterized protein	Chlamydomonas reinhardtii	19-34
27164019-1	2016	Hydrogen abstraction from toluene by OH, H, O, CH3, and HO2 radicals are important reactions in oxidation process of toluene.	Hydrogen	0-8	heme oxygenase 2	Homo sapiens	56-59
27140863-3	2016	Very little HO2(+) is seen from the reaction of H3(+) with O2, which is attributed to an efficient secondary reaction between HO2(+) and H2.	Hydrogen	137-139	heme oxygenase 2	Homo sapiens	12-15
22639973-6	2013	KEY RESULTS Calculated hydrogen bonding energies between a series of synthetic carboxylic acid compounds and the homology models of the FFA1 receptor and GPR120, using docking simulations, correlated well with the effects of the compounds on ERK phosphorylation in transfected cells (R(2) = 0.65 for FFA1 receptor and 0.76 for GPR120).	Hydrogen	23-31	free fatty acid receptor 4	Mus musculus	154-160
22639973-6	2013	KEY RESULTS Calculated hydrogen bonding energies between a series of synthetic carboxylic acid compounds and the homology models of the FFA1 receptor and GPR120, using docking simulations, correlated well with the effects of the compounds on ERK phosphorylation in transfected cells (R(2) = 0.65 for FFA1 receptor and 0.76 for GPR120).	Hydrogen	23-31	free fatty acid receptor 4	Mus musculus	327-333
27140863-3	2016	Very little HO2(+) is seen from the reaction of H3(+) with O2, which is attributed to an efficient secondary reaction between HO2(+) and H2.	Hydrogen	137-139	heme oxygenase 2	Homo sapiens	126-129
27094704-7	2016	In the active state of the GCGR, the Arg173(2.46)-Ser350(6.41) and Glu245(3.50)-Thr351(6.42) hydrogen bonds break, and the chi1 rotamer of Phe322(5.54) changes from perpendicular to parallel to helix VI.	Hydrogen	93-101	glucagon receptor	Homo sapiens	27-31
23667716-1	2013	The design, synthesis, thermodynamic and crystallographic characterization of a potent, broad spectrum, second-generation HIV-1 entry inhibitor that engages conserved carbonyl hydrogen bonds within gp120 has been achieved.	Hydrogen	176-184	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	198-203
23667716-4	2013	The crystal structure of the small molecule-gp120 complex reveals the displacement of crystallographic water and the formation of a hydrogen bond with a backbone carbonyl of the bridging sheet.	Hydrogen	132-140	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	44-49
27070195-2	2016	We report here on the discovery that weakly cohesive peptide nanostructures in terms of intermolecular hydrogen bonding, when combined with low concentrations of osteogenic growth factor, enhance both BMP-2 and Wnt mediated signaling in myoblasts and bone marrow stromal cells, respectively.	Hydrogen	103-111	bone morphogenetic protein 2	Homo sapiens	201-206
23348062-6	2013	With these direct evidences weak hydrogen bond of TGA with ethanol is proposed to be responsible for these large agglomerates and consequently super PL behavior.	Hydrogen	33-41	T-box transcription factor 1	Homo sapiens	50-53
23340693-0	2013	Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation             and neointimal hyperplasia by inhibiting reactive oxygen species production and             inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways.	Hydrogen	0-8	mitogen activated protein kinase 3	Rattus norvegicus	199-205
27070195-3	2016	Conversely, analogous nanostructures with enhanced levels of internal hydrogen bonding and cohesion lead to an overall reduction in BMP-2 signaling.	Hydrogen	70-78	bone morphogenetic protein 2	Homo sapiens	132-137
23340693-0	2013	Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation             and neointimal hyperplasia by inhibiting reactive oxygen species production and             inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways.	Hydrogen	0-8	mitogen activated protein kinase kinase 1	Rattus norvegicus	206-212
27152739-4	2016	U14-NTD exists as a dimer exhibiting broad electrostatic interactions and a network of hydrogen bonds.	Hydrogen	87-95	small nucleolar RNA, C/D box 14B	Homo sapiens	0-7
26901099-1	2016	Hydrogen sulphide (H2 S) is generated endogenously from L-cysteine (L-Cys) by the enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen	19-21	cystathionine gamma-lyase	Rattus norvegicus	128-153
22773246-1	2013	BACKGROUND: Mucopolysaccharidosis I (MPS I) is a metabolic disorder caused by alpha-L-Iduronidase (IDUA) deficiency, resulting in lysosomal accumulation of heparan (HS) and dermatan sulphate (DS).	Hydrogen	165-167	iduronidase, alpha-L	Mus musculus	78-97
22773246-1	2013	BACKGROUND: Mucopolysaccharidosis I (MPS I) is a metabolic disorder caused by alpha-L-Iduronidase (IDUA) deficiency, resulting in lysosomal accumulation of heparan (HS) and dermatan sulphate (DS).	Hydrogen	165-167	iduronidase, alpha-L	Mus musculus	99-103
26901099-1	2016	Hydrogen sulphide (H2 S) is generated endogenously from L-cysteine (L-Cys) by the enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen	19-21	cystathionine gamma-lyase	Rattus norvegicus	155-158
29920028-0	2016	[Role of Rho/ROCK signaling pathway in the protective effects of hydrogen against acute lung injury in septic mice].	Hydrogen	65-73	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	13-17
29920028-1	2016	Objective: To investigate the role of Rho/ROCK signaling pathway in the protective effects of hydrogen gas (H2) on acute lung injury (ALI) in a mouse model of sepsis.	Hydrogen	94-102	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	42-46
29920028-1	2016	Objective: To investigate the role of Rho/ROCK signaling pathway in the protective effects of hydrogen gas (H2) on acute lung injury (ALI) in a mouse model of sepsis.	Hydrogen	108-110	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	42-46
23210831-6	2013	In addition, K1/K(E) = 200 (where K(E) is the acidity constant of the monomethylester of 1) was greater than the intramolecular hydrogen bonding threshold value of 2.	Hydrogen	128-136	keratin 1	Homo sapiens	13-26
29920028-6	2016	Conclusion: H2 could improve endothelial permeability and suppress inflammation and oxidative stress to alleviate ALI in septic mice through inhibition of Rho/ROCK signaling pathway.	Hydrogen	12-14	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	159-163
28721265-0	2016	Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1alpha to enhance fatty acid metabolism.	Hydrogen	10-18	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	81-91
23258532-9	2013	Our results suggest that C. reinhardtii employs a clostridial type H(2) production pathway in the dark, especially because C. reinhardtii PFR1 was also able to allow H(2) evolution in reaction mixtures containing Clostridium acetobutylicum 2[4Fe-4S]-ferredoxin and [Fe-Fe]-hydrogenase HYDA.	Hydrogen	67-71	uncharacterized protein	Chlamydomonas reinhardtii	250-260
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Hydrogen	32-34	fibroblast growth factor 21	Mus musculus	182-209
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Hydrogen	32-34	fibroblast growth factor 21	Mus musculus	211-216
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Hydrogen	61-63	fibroblast growth factor 21	Mus musculus	182-209
23262083-9	2013	The expression of Hax-1 was 87%+-4.6, 78%+-4.9 and 54%+-8.2 of control in the murine brain endothelial cell (bEND5 cell) at 1h, 2h and 16h OGD, respectively.	Hydrogen	124-126	HCLS1 associated X-1	Mus musculus	18-23
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Hydrogen	61-63	fibroblast growth factor 21	Mus musculus	211-216
23324138-0	2013	Growth of beta-Ga2O3 and GaN nanowires on GaN for photoelectrochemical hydrogen generation.	Hydrogen	71-79	gigaxonin	Homo sapiens	25-28
28721265-10	2016	The expression of PGC-1alpha might be regulated indirectly through sequential regulation by H2, 4-hydroxy-2-nonenal, and Akt/FoxO1 signaling, as suggested in cultured cell experiments.	Hydrogen	92-94	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	18-28
23324138-0	2013	Growth of beta-Ga2O3 and GaN nanowires on GaN for photoelectrochemical hydrogen generation.	Hydrogen	71-79	gigaxonin	Homo sapiens	42-45
28721265-12	2016	H2 induces expression of the PGC-1alpha gene, followed by stimulation of the PPARalpha pathway that regulates FGF21, and the fatty acid and steroid metabolism.	Hydrogen	0-2	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	29-39
28721265-12	2016	H2 induces expression of the PGC-1alpha gene, followed by stimulation of the PPARalpha pathway that regulates FGF21, and the fatty acid and steroid metabolism.	Hydrogen	0-2	fibroblast growth factor 21	Mus musculus	110-115
27003615-4	2016	Hydrogen/deuterium-exchange mass spectrometry (HDX-MS) was used to measure local structural dynamics across a panel of variable loop truncation mutants of HIV-1 gp120, including full-length gp120, DeltaV3, DeltaV1/V2, and extended core, which includes DeltaV1/V2 and V3 loop truncations.	Hydrogen	0-8	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	161-166
23280413-6	2013	A five-point pharmacophore model consisting of one hydrogen-bond acceptor (A), two hydrogen bond donors (D), and two aromatic rings (R) was generated for both the polymorphic forms of COMT.	Hydrogen	51-59	catechol-O-methyltransferase	Homo sapiens	184-188
23280413-6	2013	A five-point pharmacophore model consisting of one hydrogen-bond acceptor (A), two hydrogen bond donors (D), and two aromatic rings (R) was generated for both the polymorphic forms of COMT.	Hydrogen	83-91	catechol-O-methyltransferase	Homo sapiens	184-188
26878852-0	2016	Complete 1H, 15N and 13C assignment of trappin-2 and 1H assignment of its two domains, elafin and cementoin.	Hydrogen	9-11	peptidase inhibitor 3	Homo sapiens	39-55
23231091-5	2013	(2)H- and (31)P-electron nuclear double resonance studies, supported by computations, show that the position for hydrogen atom abstraction from 2,5-DAPn and 2,4-DAB by the 5"-deoxyadenosyl radical occurs at the carbon adjacent to the imine, resulting in overstabilized radicals by spin delocalization through the imine into the pyridine ring of PLP.	Hydrogen	113-121	pyridoxal phosphatase	Homo sapiens	345-348
26775239-0	2016	Mesoporous Cd1-xZnxS microspheres with tunable bandgap and high specific surface areas for enhanced visible-light-driven hydrogen generation.	Hydrogen	121-129	CD1c molecule	Homo sapiens	11-14
23169449-6	2013	Nanosecond transient absorption spectroscopy measurements show that the initial step of the photocatalytic H(2)-evolution mechanism is a reductive quenching of the PS1 excited state by ascorbate, leading to the reduced form of PS1, which is then able to reduce [Rh(III)(dmbpy)(2)Cl(2)](+) to [Rh(I)(dmbpy)(2)](+).	Hydrogen	107-111	taste 2 receptor member 62 pseudogene	Homo sapiens	164-167
23169449-6	2013	Nanosecond transient absorption spectroscopy measurements show that the initial step of the photocatalytic H(2)-evolution mechanism is a reductive quenching of the PS1 excited state by ascorbate, leading to the reduced form of PS1, which is then able to reduce [Rh(III)(dmbpy)(2)Cl(2)](+) to [Rh(I)(dmbpy)(2)](+).	Hydrogen	107-111	taste 2 receptor member 62 pseudogene	Homo sapiens	227-230
26756197-3	2016	In this article, we describe an application of hydrogen deuterium exchange mass spectrometry (HDX-MS) to identify dynamic regions within type III phosphatidylinositol 4 kinase beta (PI4KIIIbeta) in complex with the GTPase Rab11.	Hydrogen	47-55	RAB11A, member RAS oncogene family	Homo sapiens	222-227
23194976-4	2013	Hydrogen/deuterium exchange mass spectrometry (HDX-MS) provides a map of the dynamic interactions unique to each of the isotypes.	Hydrogen	0-8	highly divergent homeobox	Homo sapiens	47-50
26859070-5	2016	Theoretical findings indicate that the 3,4-dihydroisocoumarin derivative 10a forms hydrogen bonds with Ser190 and Gln192 residues of KLK5.	Hydrogen	83-91	kallikrein related peptidase 5	Homo sapiens	133-137
23457571-5	2013	Hydrogen exchange lifetimes at pH 7.6 and 37 C vary between ~5 h for the unstructured N-terminus to 600 h for amide protons in the two beta-strands that form inter-molecular hydrogen bonds between amylin monomers along the length of the fibril.	Hydrogen	0-8	islet amyloid polypeptide	Homo sapiens	197-203
23457571-5	2013	Hydrogen exchange lifetimes at pH 7.6 and 37 C vary between ~5 h for the unstructured N-terminus to 600 h for amide protons in the two beta-strands that form inter-molecular hydrogen bonds between amylin monomers along the length of the fibril.	Hydrogen	174-182	islet amyloid polypeptide	Homo sapiens	197-203
27034988-2	2016	A common linear correlation between hydrogen binding energy (HBE) and pH is observed for four supported platinum-group metal catalysts (Pt/C, Ir/C, Pd/C, and Rh/C) over a broad pH range (0 to 13), suggesting that the pH dependence of HBE is metal-independent.	Hydrogen	36-44	HCL2	Homo sapiens	142-162
24171321-0	2013	Hydrogen/hydride ion relay--a mechanism for early electron transfer in cytochrome c oxidases.	Hydrogen	0-8	LOC104968582	Bos taurus	71-83
24171321-4	2013	Recently, we proposed that electrons travel from the haem edge of cytochrome c to CuA, the first metal redox centre of COX, by a hydrogen/hydride ion relay using six residues.	Hydrogen	129-137	LOC104968582	Bos taurus	66-78
23439742-0	2012	Hydrogen/Deuterium Exchange Reflects Binding of Human Centrin 2 to Ca(2+) and Xeroderma Pigmentosum Group C Peptide: An Example of EX1 Kinetics.	Hydrogen	0-8	FERM domain containing 6	Homo sapiens	131-134
26886055-5	2016	An appraisal of the energetic difference between the CDR2 conformations at 300 K revealed a localized order-disorder free-energy transition of roughly equivalent to two peptide hydrogen bonds in solution.	Hydrogen	177-185	cerebellar degeneration related protein 2	Homo sapiens	53-57
26829225-5	2016	Snu114 harbours GTP, but its putative catalytic histidine is held away from the gamma-phosphate by hydrogen bonding to a tyrosine in the amino-terminal domain of Prp8.	Hydrogen	99-107	U5 snRNP GTPase SNU114	Saccharomyces cerevisiae S288C	0-6
26829225-5	2016	Snu114 harbours GTP, but its putative catalytic histidine is held away from the gamma-phosphate by hydrogen bonding to a tyrosine in the amino-terminal domain of Prp8.	Hydrogen	99-107	U4/U6-U5 snRNP complex subunit PRP8	Saccharomyces cerevisiae S288C	162-166
26660592-3	2016	FT-IR and TGA experiments indicated that hydrogen bonding is the extensive driving force for vesicle formation.	Hydrogen	41-49	T-box transcription factor 1	Homo sapiens	10-13
25786104-0	2015	Nucleotides with altered hydrogen bonding capacities impede human DNA polymerase eta by reducing synthesis in the presence of the major cisplatin DNA adduct.	Hydrogen	25-33	DNA polymerase eta	Homo sapiens	66-84
25884403-0	2016	Meningeal blood flow is controlled by H2 S-NO crosstalk activating a HNO-TRPA1-CGRP signalling pathway.	Hydrogen	38-40	calcitonin-related polypeptide alpha	Rattus norvegicus	79-83
25579800-3	2015	A semiempirical calculation with GULP program was used to estimate the strength of hydrogen bonds in crystals: in glycolic acid they have energies of -0.337 eV/mol, -0.329 eV/mol, -0.262 eV/mol and -0.242 eV/mol, while in lactic acid two hydrogen bonds have energies of -0.283 eV/mol and -0.202 eV/mol.	Hydrogen	83-91	GULP PTB domain containing engulfment adaptor 1	Homo sapiens	33-37
25579800-3	2015	A semiempirical calculation with GULP program was used to estimate the strength of hydrogen bonds in crystals: in glycolic acid they have energies of -0.337 eV/mol, -0.329 eV/mol, -0.262 eV/mol and -0.242 eV/mol, while in lactic acid two hydrogen bonds have energies of -0.283 eV/mol and -0.202 eV/mol.	Hydrogen	238-246	GULP PTB domain containing engulfment adaptor 1	Homo sapiens	33-37
25884403-14	2016	CONCLUSIONS AND IMPLICATIONS: NO and H2 S cooperatively increased meningeal blood flow by forming HNO, which activated TRPA1 cation channels in trigeminal fibres, inducing CGRP release.	Hydrogen	37-39	calcitonin-related polypeptide alpha	Rattus norvegicus	172-176
26653463-4	2016	hIAPP(11-20) had a higher binding affinity for Tris than other selected buffers because multiple hydrogen bonds form, resulting in weaker self-aggregation of hIAPP(11-20) at the early stage of aggregation and prolonging the fibril formation process.	Hydrogen	97-105	islet amyloid polypeptide	Homo sapiens	0-5
26653463-4	2016	hIAPP(11-20) had a higher binding affinity for Tris than other selected buffers because multiple hydrogen bonds form, resulting in weaker self-aggregation of hIAPP(11-20) at the early stage of aggregation and prolonging the fibril formation process.	Hydrogen	97-105	islet amyloid polypeptide	Homo sapiens	158-163
26673530-2	2016	The experimental H2 uptake at 77 K and 1.0 atm was observed to be 0.96 wt%, which is quite impressive for a Mg(2+)-based MOF that has a BET surface area of only 150 m(2) g(-1).	Hydrogen	17-19	delta/notch like EGF repeat containing	Homo sapiens	136-139
25601566-1	2015	A recent hydrogen-deuterium exchange study of folding of the GroEL/GroES-dependent bacterial enzyme DapA has suggested that the DapA folding pathway when free in solution may differ from the folding pathway used in the presence of the GroEL/GroES chaperonin.	Hydrogen	9-17	heat shock protein family E (Hsp10) member 1	Homo sapiens	67-72
25601566-1	2015	A recent hydrogen-deuterium exchange study of folding of the GroEL/GroES-dependent bacterial enzyme DapA has suggested that the DapA folding pathway when free in solution may differ from the folding pathway used in the presence of the GroEL/GroES chaperonin.	Hydrogen	9-17	heat shock protein family E (Hsp10) member 1	Homo sapiens	241-246
26785146-3	2016	To understand the basic principle of Hsf1 activation we analyzed temperature-induced alterations in the conformational dynamics of Hsf1 by hydrogen exchange mass spectrometry.	Hydrogen	139-147	heat shock transcription factor 1	Homo sapiens	37-41
25542181-4	2015	A treatment of EAG2-expressing cells with the Ca(2+) ionophore A23187 for 1h reduces the full-length protein by ~80% with a concomitant appearance of 30-35-kDa peptides.	Hydrogen	74-76	potassium voltage-gated channel subfamily H member 5	Rattus norvegicus	15-19
26785146-3	2016	To understand the basic principle of Hsf1 activation we analyzed temperature-induced alterations in the conformational dynamics of Hsf1 by hydrogen exchange mass spectrometry.	Hydrogen	139-147	heat shock transcription factor 1	Homo sapiens	131-135
32020923-8	2016	The column density to the hardest emission component, N H ~1024 H cm-2, marked one of the highest values ever observed for eta Car, strongly suggesting the increased obscuration of the wind-wind colliding X-ray emission by the thick primary stellar wind prior to superior conjunction.	Hydrogen	54-57	endothelin receptor type A	Homo sapiens	123-126
26659906-7	2016	Accordingly, hydrogen bonding, salt bridges and pi-pi stacking interactions coexist in the highly ordered packing network proposed for the Fmoc-RGDS amphiphile.	Hydrogen	13-21	ral guanine nucleotide dissociation stimulator	Homo sapiens	144-148
26625841-6	2016	DMD simulations indicated that the strong binding of hIAPP to GO nanosheets was driven by hydrogen bonding and aromatic stacking and that the strong peptide-GO binding efficiently inhibited hIAPP self-association and aggregation on the nanosheet surface.	Hydrogen	90-98	islet amyloid polypeptide	Homo sapiens	53-58
25354586-6	2015	Consistent with these data, mice exposed to 250 ppm CO (1h/day for 14 days) exhibited a marked decrease in FGF-2-induced Matrigel plug angiogenesis (p&lt;0.05).	Hydrogen	56-58	fibroblast growth factor 2	Mus musculus	107-112
25377300-4	2015	In THP-1 cells, AMPKalpha1 was phosphorylated within 1h of menadione (15 muM)-triggered increases in [reactive oxygen species (ROS)]cyto, an effect which was followed by upregulation of PPARgamma and several of its target genes (PGC-1alpha, liver X receptor alpha [LXRalpha] and ATP-binding cassette subfamily A, member 1 [ABCA1]; 24-72 h), with these effects being blunted by co-administration of vitamin C (62.5 muM).	Hydrogen	53-55	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	16-26
25377300-4	2015	In THP-1 cells, AMPKalpha1 was phosphorylated within 1h of menadione (15 muM)-triggered increases in [reactive oxygen species (ROS)]cyto, an effect which was followed by upregulation of PPARgamma and several of its target genes (PGC-1alpha, liver X receptor alpha [LXRalpha] and ATP-binding cassette subfamily A, member 1 [ABCA1]; 24-72 h), with these effects being blunted by co-administration of vitamin C (62.5 muM).	Hydrogen	53-55	nuclear receptor subfamily 1 group H member 3	Homo sapiens	265-273
25601683-2	2015	Here, htt aggregate structure has been examined using hydrogen-deuterium exchange techniques coupled with tandem mass spectrometry.	Hydrogen	54-62	huntingtin	Homo sapiens	6-9
25363721-1	2014	First-principles calculations were performed to study the hydrogen bond in the camphorsulfonic (CSA) acid-doped polyaniline system.	Hydrogen	58-66	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	96-99
26290993-8	2012	The resulting SMP2/aDZ, MP2(erfc, aDZ), and MP2(terfc, aDZ) methods perform far better than MP2/aDZ across systems with hydrogen-bonding, dispersion, and mixed interactions at a fraction of MP2/CBS computational cost.	Hydrogen	120-128	lipin 3	Homo sapiens	14-18
22824487-3	2012	The N-terminal sequences upstream of TGF-beta-type cysteine-knot domains in BMP-2, 7 and 14 contain the basic residues arginine and lysine, which are key components of the heparin/HS-binding sites, with these residues being highly non-conserved.	Hydrogen	180-182	bone morphogenetic protein 2	Homo sapiens	76-81
22995912-8	2012	Here we show that mutations of two distant Kir2.1 cytosolic residues, Leu-222 and Asn-251, form a two-way molecular switch that controls channel modulation by cholesterol and affects critical hydrogen bonding.	Hydrogen	192-200	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	43-49
23014263-0	2012	Cooperativity between hydrogen bonds and beryllium bonds in (H2O)(n)BeX2 (n = 1-3, X = H, F) complexes.	Hydrogen	22-30	brain expressed X-linked 2	Homo sapiens	68-72
23046344-0	2012	Mapping the conformational stability of maltose binding protein at the residue scale using nuclear magnetic resonance hydrogen exchange experiments.	Hydrogen	118-126	myelin basic protein	Homo sapiens	40-63
23046344-3	2012	Here we determined, by using hydrogen exchange (HX) nuclear magnetic resonance experiments, the apparent stabilization free energies of 101 residues of MBP bound to beta-cyclodextrin (MBP-betaCD) under native conditions.	Hydrogen	29-37	myelin basic protein	Homo sapiens	152-155
23046344-3	2012	Here we determined, by using hydrogen exchange (HX) nuclear magnetic resonance experiments, the apparent stabilization free energies of 101 residues of MBP bound to beta-cyclodextrin (MBP-betaCD) under native conditions.	Hydrogen	29-37	myelin basic protein	Homo sapiens	184-187
23284480-3	2012	In the crystal, the mol-ecules are linked by non-classical C-H N and C-H O hydrogen bonds, building an infinite three-dimensional network.	Hydrogen	75-83	chimerin 1	Homo sapiens	59-72
22863680-6	2012	Furthermore, pre-treatment of the co-cultured cells with 12-(3-adamantan-1-yl-ureido)-dodecanoic acid, an inhibitor of the EET metabolizing enzyme, soluble epoxide hydrolase (sEH), before H(2)O(2) stimulation (1mM, for 1h) increased cell viability.	Hydrogen	219-221	epoxide hydrolase 2	Homo sapiens	175-178
23066313-11	2012	There were no significant difference between Hydrogen-group and contrast-group at pre-operation (P = 0.653, P = 0.423), but after massive hepatotectomy, the TNF-alpha and IL-6 levels increase, and its in Hydrogen-group was significantly low compared with contrast-group (P = 0.022, P = 0.013, vs. P = 0.016, P = 0.012), respectively.	Hydrogen	204-212	tumor necrosis factor	Sus scrofa	157-166
22902635-8	2012	Hydrogen treatment also induced the transcription factors C/EBPalpha and C/EBPbeta, which are known regulators of surfactant-related genes.	Hydrogen	0-8	CCAAT enhancer binding protein beta	Homo sapiens	73-82
22798378-5	2012	The predicted binding mode of 4HPR with mTOR was based on a homology computer model, which showed that 4HPR could bind in the ATP-binding pocket of the mTOR protein through hydrogen bonds and hydrophobic interactions.	Hydrogen	173-181	haptoglobin-related protein	Homo sapiens	31-34
22609436-4	2012	The increase in the e(2)qQ/h and eta describing EFG tendency towards non-spherical symmetry was significantly greater upon the reduction of NO(2) site than upon hydrogen abstraction from NH site.	Hydrogen	161-169	endothelin receptor type A	Homo sapiens	33-36
22782901-10	2012	The inhibitor binds MIF mainly on the protein surface through hydrophobic interactions that are stabilized by hydrogen bonding with four highly specific residues from three different monomers.	Hydrogen	110-118	macrophage migration inhibitory factor	Homo sapiens	20-23
22857012-7	2012	The free energy decomposition of each residue reveals that the residue Trp334 dominates the most binding free energies among all residues and that the activities for these molecules to the sEH are not decided by hydrogen bonds or a certain residue but by the common effect of multiple side chains in the active site.	Hydrogen	212-220	epoxide hydrolase 2	Homo sapiens	189-192
25548518-10	2014	A molecular docking study showed that XKB bound to the active site of human cytochrome P450 3A4 and rat Cyp3a2 homology model via the formation of hydrogen bonds.	Hydrogen	147-155	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	104-110
26729491-11	2016	The former is aided by the unusual polar nature of the triazole ring, allowing it to potentially form a unique C-H...O 2.9-A hydrogen bond with S130 in KPC-2.	Hydrogen	125-133	UBA domain containing 1	Homo sapiens	152-157
25304362-5	2014	The results showed that miR-134 expression levels increased in primary cultured neuronal cells and mouse brain from 12h to 7 day reoxygenation/reperfusion after 1h OGD or 1h MCAO treatment.	Hydrogen	161-163	microRNA 134	Mus musculus	24-31
25304362-5	2014	The results showed that miR-134 expression levels increased in primary cultured neuronal cells and mouse brain from 12h to 7 day reoxygenation/reperfusion after 1h OGD or 1h MCAO treatment.	Hydrogen	171-173	microRNA 134	Mus musculus	24-31
25490155-4	2014	The dynamics of the complex were defined using hydrogen-deuterium exchange, revealing a novel 20-residue ordered region C-terminal to the VPS34 C2 domain.	Hydrogen	47-55	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	138-143
22610453-0	2012	Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors.	Hydrogen	27-35	serine protease 3	Homo sapiens	102-113
22615146-4	2012	This hydrogen bond results in the increase of delta((1) H-6) and (1) J(C-6,H-6) parameters.	Hydrogen	5-13	complement C6	Homo sapiens	71-74
26870589-3	2016	In addition, inversion-related pairs of mol-ecules are linked into dimers by pairs of weak C-Cl pi(pyrid-yl) inter-actions, which link the hydrogen-bonded chains into (100) sheets.	Hydrogen	139-147	crystallin gamma C	Homo sapiens	91-95
22702513-2	2012	The current study sought to exploit the C-terminal binding site of Hsp90 to determine whether the optimization of hydrogen bonding and hydrophobic interactions of second-generation novologues could enhance neuroprotective activity.	Hydrogen	114-122	heat shock protein, 3	Mus musculus	67-72
26151827-7	2016	Interestingly, 8%HS caused a more profound and earlier ANG II-induced hypertension in UB(Bdkrb2-/-) (129 +- 2 to 166 +- 3 mmHg) as compared to control (128 +- 2 to 158 +- 2 mmHg) and it was accompanied by body weight loss and increased mortality.	Hydrogen	17-19	bradykinin receptor, beta 2	Mus musculus	89-95
25929263-6	2016	Molecular docking studies revealed that the curcumin binds in the large hydrophobic cavity of kinase domain of CAMK4 through several hydrophobic and hydrogen-bonded interactions.	Hydrogen	149-157	calcium/calmodulin dependent protein kinase IV	Homo sapiens	111-116
22612449-6	2012	In contrast to the classical reductive SMSI in the TiO(2) supported group VIII metals which appears after high temperature reduction in H(2) with electron transfer from the support to metals, the oxidative SMSI in Au/ZnO-nanorod system gives oxygen-induced burial and electron transfer from gold to support.	Hydrogen	136-140	cytochrome c oxidase subunit 8A	Homo sapiens	74-78
26832618-1	2016	Human aldehyde dehydrogenase 2 (ALDH2) is a 56 kDa mitochondrial protein that forms homodimers through hydrogen bonding interactions between the Glu487 and Arg475 residues of two ALDH2 proteins.	Hydrogen	17-25	aldehyde dehydrogenase 2 family member	Homo sapiens	32-37
22562405-0	2012	Rational design of hyperbranched 3D heteroarrays of SrS/CdS: synthesis, characterization and evaluation of photocatalytic properties for efficient hydrogen generation and organic dye degradation.	Hydrogen	147-155	Russell-Silver dwarfism	Homo sapiens	52-55
22562405-3	2012	The prepared 3D SrS/CdS exhibited improved photocatalytic activity for water splitting leading to H(2) generation (AQY 10%) and nearly complete degradation of methyl orange (MO) dye.	Hydrogen	98-102	Russell-Silver dwarfism	Homo sapiens	16-19
26832618-1	2016	Human aldehyde dehydrogenase 2 (ALDH2) is a 56 kDa mitochondrial protein that forms homodimers through hydrogen bonding interactions between the Glu487 and Arg475 residues of two ALDH2 proteins.	Hydrogen	17-25	aldehyde dehydrogenase 2 family member	Homo sapiens	179-184
26456770-1	2015	A g-C3N4/nanocarbon/ZnIn2S4 (CN/C/ZIS) nanocomposite with enhanced photocatalytic H2 production performance has been successfully synthesized.	Hydrogen	82-84	zinc finger RANBP2-type containing 2	Homo sapiens	34-37
22293507-9	2012	The levels of two fragments of caspase 9 in the cortex were higher in the control group compared with the hyperbaric oxygen-exposed group 1h after seizures (p&lt;0.01).	Hydrogen	138-140	caspase 9	Mus musculus	31-40
26172469-2	2015	Two intramolecular hydrogen bonds (HB1 and HB2) are formed between hydroxyl and carbonyl groups of AS1.	Hydrogen	19-27	keratin 82	Homo sapiens	43-46
22803330-8	2012	Thus, present study reveals that hydrogen bonding with 03 of PLP with a hydrogen bond donor residue provided by the enzyme plays an important role in the decarboxylation process.	Hydrogen	33-41	pyridoxal phosphatase	Homo sapiens	61-64
22803330-8	2012	Thus, present study reveals that hydrogen bonding with 03 of PLP with a hydrogen bond donor residue provided by the enzyme plays an important role in the decarboxylation process.	Hydrogen	72-80	pyridoxal phosphatase	Homo sapiens	61-64
22426808-11	2012	The docking data suggested that C-K forms hydrogen bonds with Lys253, Thr904 and Gly362 in caspase 8, and with Thr62, Ser63 and Arg207 in caspase 9.	Hydrogen	42-50	caspase 8	Homo sapiens	91-100
26524525-6	2015	However, the hydroxyl group of 5hmC and carbonyl group of 5fC face towards the opposite direction because the hydroxymethyl group of 5hmC and formyl group of 5fC adopt restrained conformations through forming hydrogen bonds with the 1-carboxylate of NOG and N4 exocyclic nitrogen of cytosine, respectively.	Hydrogen	209-217	noggin	Homo sapiens	250-253
22813587-5	2012	In accordance with the proposed hypothesis, Rp-3":5"-AMPS similarly to 3":5"-AMP forms a hydrogen bond with the amide group of A326; however, the properties of this bond together with the position of the sulfur atom prevent the movement of A326.	Hydrogen	89-97	adenylosuccinate lyase	Homo sapiens	53-57
26524525-7	2015	Biochemical analyses indicate that the substrate preference of TET2 results from the different efficiencies of hydrogen abstraction in TET2-mediated oxidation.	Hydrogen	111-119	tet methylcytosine dioxygenase 2	Homo sapiens	63-67
26524525-7	2015	Biochemical analyses indicate that the substrate preference of TET2 results from the different efficiencies of hydrogen abstraction in TET2-mediated oxidation.	Hydrogen	111-119	tet methylcytosine dioxygenase 2	Homo sapiens	135-139
26682016-6	2015	Considering on the effect of hydrophobic interaction and hydrogen bonding between abiraterone and CYP17A1, the key residues of Phe114, Ile371, Val482, and Asn202 were identified.	Hydrogen	57-65	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	98-105
23807909-0	2012	Novel Fe3+-Based 1H MRI beta-Galactosidase Reporter Molecules** There is increasing interest in the development of reporter agents to reveal enzyme activity in vivo using small animal imaging.	Hydrogen	17-19	galactosidase beta 1	Homo sapiens	24-42
23807909-5	2012	We now report the design and successful synthesis of novel analogues together with characterization of 1H MRI contrast based on both T1 and T2 response to beta-gal activity in vitro for the lead agent.	Hydrogen	103-105	galactosidase beta 1	Homo sapiens	155-163
22366186-1	2012	Regulation of intracellular pH (pHi) and protection against cytosolic acidification is primarily a function of the ubiquitous plasma membrane Na+/H+exchanger-1 (NHE1), which uses a highly conserved process to transfer cytosolic hydrogen ions (H+) across plasma membranes in exchange for extracellular sodium ions (Na+).	Hydrogen	228-236	glucose-6-phosphate isomerase	Homo sapiens	32-35
26422179-3	2015	In this work, the stability of the immobilized Re(hoz)2 complex is shown to depend on kinetic competition between three processes: (1) ReV(hoz)2 oxidation by ClO4- and its reduction intermediates ClOx-, (2) ReVII(hoz)2 reduction by Pd-activated hydrogen, and (3) hydrolytic ReVII(hoz)2 decomposition.	Hydrogen	245-253	cut like homeobox 1	Homo sapiens	196-200
22417889-8	2012	The results from the fittings indicated that partition processes govern mainly the ZIC-HILIC separation, but also adsorption processes via hydrogen bonds occurred for hydrogen donor analytes.	Hydrogen	167-175	Zic family member 1	Homo sapiens	83-86
30090268-3	2015	The rate-determining step in the catalytic cycle is hydrogen atom transfer from H3Trip to O2 in the H3Trip/O2 complex to produce the radical pair (H3Trip + HO2 ) as an intermediate, which was detected as a triplet EPR signal with fine-structure by the EPR measurements at low temperature.	Hydrogen	52-60	heme oxygenase 2	Homo sapiens	156-159
22321795-7	2012	The results suggest that a large hydrophobic effect combined with extensive main-chain hydrogen bonding enables Caf1M to rapidly bind an early folding intermediate of Caf1 and direct its partial folding.	Hydrogen	87-95	F1 capsule protein	Yersinia pestis	112-117
22321795-7	2012	The results suggest that a large hydrophobic effect combined with extensive main-chain hydrogen bonding enables Caf1M to rapidly bind an early folding intermediate of Caf1 and direct its partial folding.	Hydrogen	87-95	chromatin assembly factor 1 subunit A	Homo sapiens	112-116
21779926-0	2012	1H, 15N and 13C backbone chemical shift assignment of the titin A67-A68 domain tandem.	Hydrogen	0-2	titin	Homo sapiens	58-63
25547287-1	2015	Hydrogen release from the splitting of water by simply using sunlight as the only energy source is an old human dream that could finally become a reality.	Hydrogen	0-8	potassium voltage-gated channel interacting protein 3	Homo sapiens	112-117
26103447-4	2015	The results demonstrated that HS induced apoptosis in the SCs exposed to 43 C for 1h as Fas/FasL was activated and caspase-3 was cleaved, the cells apoptotic rate was decreased.	Hydrogen	82-84	caspase 3	Bos taurus	115-124
22370337-0	2012	Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.	Hydrogen	15-23	nitric oxide synthase 1	Homo sapiens	90-120
22370337-5	2012	Crystal structures of the inhibitors in the nNOS active site confirm the predicted non-intramolecular hydrogen bonded binding mode.	Hydrogen	102-110	nitric oxide synthase 1	Homo sapiens	44-48
26230135-4	2015	Key intermediates of the proposed mechanism for the pathway leading to H2 are the porphyrin dye"s highly oxidizing singlet excited state (1)A* (E ~ +1.3 V vs NHE), its strongly reducing isobacteriochlorin analogue (E ~ +0.95 V), and the Co(I) form of C (E ~ -0.8 V), acting as catalyst for H2 formation.	Hydrogen	71-73	solute carrier family 9 member C1	Homo sapiens	158-161
22527961-6	2012	Macrocycles with an ether linker have potent JAK2 activity with the ether oxygen forming a hydrogen bond to Ser936.	Hydrogen	91-99	Janus kinase 2	Homo sapiens	45-49
22527961-7	2012	A hydrogen bond to the equivalent residues of JAK3 and most CDKs cannot be formed resulting in good selectivity for JAK2 over JAK3 and CDKs.	Hydrogen	2-10	Janus kinase 2	Homo sapiens	116-120
26230135-4	2015	Key intermediates of the proposed mechanism for the pathway leading to H2 are the porphyrin dye"s highly oxidizing singlet excited state (1)A* (E ~ +1.3 V vs NHE), its strongly reducing isobacteriochlorin analogue (E ~ +0.95 V), and the Co(I) form of C (E ~ -0.8 V), acting as catalyst for H2 formation.	Hydrogen	290-292	solute carrier family 9 member C1	Homo sapiens	158-161
26440750-3	2015	In the present study, hydrogen exchange mass spectrometry (HX MS) was used to study conformational changes in downregulated Hck that result from Nef binding, as well as the impact of DFP-4AB on these changes.	Hydrogen	22-30	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	124-127
22755010-5	2012	The TGA results at temperatures up to 600 degrees C indicate that silver reduction is less complete in an argon stream than in a hydrogen stream.	Hydrogen	129-137	T-box transcription factor 1	Homo sapiens	4-7
25183649-14	2014	We predict that mutations in ArsA propagate changes in hydrogen bonding and salt bridges to the ArsA-ArsD interface that affect their interactions.	Hydrogen	55-63	arylsulfatase A	Homo sapiens	29-33
25183649-14	2014	We predict that mutations in ArsA propagate changes in hydrogen bonding and salt bridges to the ArsA-ArsD interface that affect their interactions.	Hydrogen	55-63	arylsulfatase A	Homo sapiens	96-100
26292934-4	2015	The results can be well explained by the presence of an oppositely oriented quasi-bilayer structure of butanol molecules, where the bottom layer is strongly bound by hydrogen-bonding with the PF6(-) anion.	Hydrogen	166-174	sperm associated antigen 17	Homo sapiens	192-195
25293653-0	2014	Enhanced visible-light photocatalytic H2 production by Znx Cd1-x S modified with earth-abundant nickel-based cocatalysts.	Hydrogen	38-40	CD1c molecule	Homo sapiens	59-62
25293653-1	2014	The application of various earth-abundant Ni species, such as NiS, Ni, Ni(OH)2 , and NiO, as a co-catalyst in a Znx Cd1-x S system for visible-light photocatalytic H2 production was investigated for the first time.	Hydrogen	164-166	CD1c molecule	Homo sapiens	116-119
25293653-3	2014	Surprisingly, Ni(OH)2 -loaded Znx Cd1-x S exhibits a very high photocatalytic H2 -production rate of 7160 mumol h(-1)  g(-1) with a quantum efficiency of 29.5 % at 420 nm, which represents one of the most efficient metal sulfide photocatalysts without a Pt co-catalyst to date.	Hydrogen	78-80	CD1c molecule	Homo sapiens	34-37
25293653-6	2014	This paper reports the optimization of the Znx Cd1-x S system by selecting an appropriate Ni-based co-catalyst, Ni(OH)2 , from a series of Ni species to achieve the highest photocatalytic H2 -production activity for the first time and also reveals the roles of these Ni species in the photocatalytic activity.	Hydrogen	188-190	CD1c molecule	Homo sapiens	47-50
26137510-7	2014	HbA1c level of less than 7.0% was achieved in 52.5% of the MES + HS-treated T2DM patients in contrast to 15% of the non-treated period.	Hydrogen	65-67	hemoglobin subunit alpha 1	Homo sapiens	0-4
25260221-5	2014	The binding was studied by isothermal titration calorimetry (ITC) and the result revealed that the complexation is enthalpy driven, the DeltaH &lt;0, DeltaS &lt;0 indicates the formation of hydrogen bonds between beta-galactosidase and CuO NPs occurs.	Hydrogen	190-198	galactosidase beta 1	Homo sapiens	213-231
22085909-1	2012	Cytochrome c(6A) is a eukaryotic member of the Class I cytochrome c family possessing a high structural homology with photosynthetic cytochrome c(6) from cyanobacteria, but structurally and functionally distinct through the presence of a disulfide bond and a heme mid-point redox potential of +71mV (vs normal hydrogen electrode).	Hydrogen	310-318	Cytochrome c	Arabidopsis thaliana	0-12
22085909-1	2012	Cytochrome c(6A) is a eukaryotic member of the Class I cytochrome c family possessing a high structural homology with photosynthetic cytochrome c(6) from cyanobacteria, but structurally and functionally distinct through the presence of a disulfide bond and a heme mid-point redox potential of +71mV (vs normal hydrogen electrode).	Hydrogen	310-318	Cytochrome c	Arabidopsis thaliana	55-67
22266943-6	2012	Whereas the overall structure of CYP17A1 provides a rationale for understanding many mutations that are found in patients with steroidogenic diseases, the active site reveals multiple steric and hydrogen bonding features that will facilitate a better understanding of the enzyme"s dual hydroxylase and lyase catalytic capabilities and assist in rational drug design.	Hydrogen	195-203	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	33-40
22396159-8	2012	The distinct topologies of the HBS of FGF19 and FGF23 prevent HS from direct hydrogen bonding with the backbone atoms of the HBS of these ligands and accordingly decrease the HS binding affinity of this subfamily.	Hydrogen	77-85	fibroblast growth factor 19	Homo sapiens	38-43
21990279-5	2012	Colored products were yielded from single substrates possessing a value of the oxidation peak (E(o)) lower than 1,150 mV vs. normal hydrogen electrode (NHE).	Hydrogen	132-140	solute carrier family 9 member C1	Homo sapiens	152-155
26292934-5	2015	MD simulations reveal that the hydrogen-bonding of butanol with the PF6(-) anion causes the preferential orientation of the butanols; the restriction on the rotational distribution of the terminal methyl group along their C3 axis enhances the r(-) mode.	Hydrogen	31-39	sperm associated antigen 17	Homo sapiens	68-71
26455726-1	2015	Creating an artificial functional mimic of the mitochondrial enzyme cytochrome c oxidase (CcO) has been a long-term goal of the scientific community as such a mimic will not only add to our fundamental understanding of how CcO works but may also pave the way for efficient electrocatalysts for oxygen reduction in hydrogen/oxygen fuel cells.	Hydrogen	314-322	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	68-88
26455726-1	2015	Creating an artificial functional mimic of the mitochondrial enzyme cytochrome c oxidase (CcO) has been a long-term goal of the scientific community as such a mimic will not only add to our fundamental understanding of how CcO works but may also pave the way for efficient electrocatalysts for oxygen reduction in hydrogen/oxygen fuel cells.	Hydrogen	314-322	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	90-93
26669179-3	2015	It is showed that the compound 1 is composed of V12B16 clusters unit and dap which is as a counter ion, and a two-dimensional layered structure is obtained by the effect of hydrogen bonding between the cluster units and dap, and between the layers via strong hydrogen bonds to form a three-dimensional supramolecular structure.	Hydrogen	173-181	death associated protein	Homo sapiens	220-223
25197769-3	2014	We successfully controlled the proton conductivity by cleavage of the hydrogen bonds in a proton-conducting pathway, showing that the 2-D hydrogen-bonding networks in the MOF truly contribute to the high proton conductivity.	Hydrogen	138-146	lysine acetyltransferase 8	Homo sapiens	171-174
26253656-9	2015	H2 could suppress the release of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1), and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and high-mobility group box 1 protein (HMGB1).	Hydrogen	0-2	intercellular adhesion molecule 1	Mus musculus	113-151
25197769-4	2014	This is the first example of the control of proton conductivity by ion substitution in a well-defined hydrogen-bonding network within a MOF.	Hydrogen	102-110	lysine acetyltransferase 8	Homo sapiens	136-139
26253656-9	2015	H2 could suppress the release of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1), and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and high-mobility group box 1 protein (HMGB1).	Hydrogen	0-2	intercellular adhesion molecule 1	Mus musculus	153-159
26253656-9	2015	H2 could suppress the release of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1), and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and high-mobility group box 1 protein (HMGB1).	Hydrogen	0-2	high mobility group box 1	Mus musculus	264-289
24906731-2	2014	Both ionic (band at 1131 cm(-1)) and hydrogen bond (bands at 2500 and 3500 cm(-1)) interactions between polyaniline and iota-CGN were determined by infrared spectroscopy.	Hydrogen	37-45	cingulin	Homo sapiens	125-128
26253656-9	2015	H2 could suppress the release of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1), and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and high-mobility group box 1 protein (HMGB1).	Hydrogen	0-2	high mobility group box 1	Mus musculus	299-304
26051784-6	2015	Molecular docking study of 21 was performed and showed the hydrogen bonds and hydrophobic interaction with the amino acid residues of the active site of CYP17.	Hydrogen	59-67	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	153-158
24239247-0	2014	An 1H-MRS framework predicts the onset of Alzheimer"s disease symptoms in PSEN1 mutation carriers.	Hydrogen	3-5	presenilin 1	Homo sapiens	74-79
26226559-0	2015	Allosteric Breakage of the Hydrogen Bond within the Dual-Histidine Motif in the Active Site of Human Pin1 PPIase.	Hydrogen	27-35	peptidylprolyl isomerase like 3	Homo sapiens	106-112
24953769-0	2014	Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.	Hydrogen	72-80	nuclear receptor subfamily 1 group H member 4	Homo sapiens	33-36
22154552-10	2012	The hydrogen-rich saline also inhibited the expression of glial fibrillary acidic protein (GFAP) in Muller cells, CD11b in microglia, and iNOS and GRP78 in glial cells.	Hydrogen	4-12	glial fibrillary acidic protein	Cavia porcellus	58-89
22154552-10	2012	The hydrogen-rich saline also inhibited the expression of glial fibrillary acidic protein (GFAP) in Muller cells, CD11b in microglia, and iNOS and GRP78 in glial cells.	Hydrogen	4-12	glial fibrillary acidic protein	Cavia porcellus	91-95
22154552-10	2012	The hydrogen-rich saline also inhibited the expression of glial fibrillary acidic protein (GFAP) in Muller cells, CD11b in microglia, and iNOS and GRP78 in glial cells.	Hydrogen	4-12	nitric oxide synthase, inducible	Cavia porcellus	138-142
26130721-4	2015	Using amine crosslinking and hydrogen-deuterium exchange coupled to mass spectrometry, we describe the architecture of the Prp19 sub-complex that contains CTNNBL1.	Hydrogen	29-37	pre-mRNA processing factor 19	Homo sapiens	123-128
21956503-5	2012	However, the number of cells secreting TH2 cytokines IL-4 and IL-5 in hydrogen -peroxide-treated group did not change.	Hydrogen	70-78	interleukin 5	Homo sapiens	62-66
25068438-5	2014	Using group-balanced isodesmic reactions, the standard enthalpies of formation for HFE-449mecf and radicals generated by hydrogen abstraction, are also reported.	Hydrogen	121-129	homeostatic iron regulator	Homo sapiens	83-86
22158899-4	2011	The paracaspase and the Ig domains appear as a single folding unit and interact with each other through extensive van der Waals contacts and hydrogen bonds.	Hydrogen	141-149	MALT1 paracaspase	Homo sapiens	4-15
26263895-3	2015	RESULTS: We show that the Sec4p residue serine 29 forms a hydrogen bond with the nucleotide.	Hydrogen	58-66	Rab family GTPase SEC4	Saccharomyces cerevisiae S288C	26-31
22015602-11	2011	Importantly, hydrogen inhibited the activation of P-JNK, and also reversed changes in Bax, Bcl-xl and caspase-3.	Hydrogen	13-21	BCL2-like 1	Mus musculus	91-97
25132342-6	2014	In vivo, after 1h of an OF exposure-with habituation to the environment-, there was an increase in GluN1 and GluN2A subunits in the rat hippocampus, without significant changes in GluN2B.	Hydrogen	15-17	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	99-104
26252778-0	2015	1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents.	Hydrogen	0-2	FAT atypical cadherin 1	Homo sapiens	24-27
25093354-4	2014	The methanol and NCL molecules interact via short O-H...O hydrogen bonds.	Hydrogen	58-66	nucleolin	Homo sapiens	17-20
22105349-4	2011	We provide evidence that cortactin-cofilin binding is regulated by local pH changes at invadopodia that are mediated by the sodium-hydrogen exchanger NHE1.	Hydrogen	131-139	cofilin 1	Homo sapiens	35-42
26110992-0	2015	Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry.	Hydrogen	112-120	furin, paired basic amino acid cleaving enzyme	Homo sapiens	60-65
22101937-6	2011	A hydrogen bond network in the SMN Tudor domain, including Glu134 and a tyrosine hydroxyl of the aromatic cage, enhances cation-pi interactions and is impaired by a mutation causing an E134K substitution associated with spinal muscular atrophy.	Hydrogen	2-10	survival of motor neuron 1, telomeric	Homo sapiens	31-34
21703367-4	2011	Model studies indicate that protonation of the pyridine ring of PLP leads to a dominance of the ketoenamine form, where the intramolecular OHN hydrogen bond of PLP exhibits a zwitterionic state.	Hydrogen	143-151	pyridoxal phosphatase	Homo sapiens	64-67
21703367-4	2011	Model studies indicate that protonation of the pyridine ring of PLP leads to a dominance of the ketoenamine form, where the intramolecular OHN hydrogen bond of PLP exhibits a zwitterionic state.	Hydrogen	143-151	pyridoxal phosphatase	Homo sapiens	160-163
24837392-11	2014	We propose that Methanocella methanogens cope with low H2 and syntrophic growth by (i) stabilizing the Mvh/Hdr/Fwd complex and (ii) activating formatedependent methanogenesis.	Hydrogen	55-57	CoB--CoM heterodisulfide reductase iron-sulfur subunit B family protein	Methanocella conradii HZ254	107-110
24972791-2	2014	As an example, we show the specific binding of the common antihypertension drug felodipine to the oncogenic Aurora A kinase protein via hydrogen bonding interactions with Tyr-212 residue to specifically inhibit its activity.	Hydrogen	136-144	aurora kinase A	Homo sapiens	108-116
26110992-6	2015	In this manuscript, we measured the pKa values of histidines within the propeptides of furin and proprotein convertase 1/3 using a histidine hydrogen-deuterium exchange mass spectrometry approach.	Hydrogen	141-149	furin, paired basic amino acid cleaving enzyme	Homo sapiens	87-92
26146187-5	2015	Molecular dynamics simulations revealed that TRPV4-K462 generated an alternating hydrogen network with E745 (TRP box) and D425 (pre-S1 linker), and that K462Q mutation affected subunit folding.	Hydrogen	81-89	transient receptor potential cation channel subfamily V member 4	Homo sapiens	45-50
24819164-7	2014	The surface and mass specific activities of the Pt-Y(2)O(3)/C catalyst towards the ORR at 0.9 V (vs. the reversible hydrogen electrode, RHE) are (54.3+-1.2) muA cm(-2)(Pt) and MA=(23.1+-0.5) mA mg(-1)(Pt), respectively.	Hydrogen	116-124	factor interacting with PAPOLA and CPSF1	Homo sapiens	136-139
22038805-1	2011	In the present study, the molecular dynamics simulation technique is employed to investigate the hydrogen abstraction possibility from sugar of DNA in two designed complexes of copper-based chemical nuclease [Cu(BPA)](2+) bis(2-pyridylmethyl) amine (BPA) or [Cu(IDB)](2+) N,N-bis(2-benzimidazolylmethyl) amine (IDB) bound to the zinc finger protein Tramtrack (TTK).	Hydrogen	97-105	TTK protein kinase	Homo sapiens	349-358
22038805-1	2011	In the present study, the molecular dynamics simulation technique is employed to investigate the hydrogen abstraction possibility from sugar of DNA in two designed complexes of copper-based chemical nuclease [Cu(BPA)](2+) bis(2-pyridylmethyl) amine (BPA) or [Cu(IDB)](2+) N,N-bis(2-benzimidazolylmethyl) amine (IDB) bound to the zinc finger protein Tramtrack (TTK).	Hydrogen	97-105	TTK protein kinase	Homo sapiens	360-363
22038805-4	2011	The positions of copper-based chemical nucleases bound to TTK may substantially influence the hydrogen abstraction possibility.	Hydrogen	94-102	TTK protein kinase	Homo sapiens	58-61
25010341-4	2014	We found that the orientations that these compounds adopt inside GSK3beta binding site prioritize the formation of hydrogen bond (HB) interactions between the maleimide group and the residues at the hinge region (residues Val135 and Asp133), and adopt propeller-like conformations (where the maleimide is the propeller axis and the heterocyclic substituents are two slanted blades).	Hydrogen	115-123	glycogen synthase kinase 3 beta	Homo sapiens	65-73
25789870-0	2015	Different conformational dynamics of PDZ1 and PDZ2 in full-length EBP50 analyzed by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	84-92	SLC9A3 regulator 1	Homo sapiens	66-71
24909783-0	2014	Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	101-109	progesterone receptor	Homo sapiens	67-88
21965542-4	2011	These structures and Nuclear Magnetic Resonance (NMR) data indicate that the nematode Ascaris suum eIF4E binds the two different caps in a similar manner except for the loss of a single hydrogen bond on binding the m(2,2,7)G-cap.	Hydrogen	186-194	eukaryotic translation initiation factor 4E	Homo sapiens	99-104
21880708-4	2011	All N-methylated analogues showed impaired binding affinities to IR, which suggests a direct IR-interacting role for the respective amide hydrogens.	Hydrogen	138-147	insulin receptor	Homo sapiens	65-67
21880708-4	2011	All N-methylated analogues showed impaired binding affinities to IR, which suggests a direct IR-interacting role for the respective amide hydrogens.	Hydrogen	138-147	insulin receptor	Homo sapiens	93-95
24909783-2	2014	A hydrogen/deuterium exchange (HDX) mass-spectrometry-based investigation of TATA box-binding protein (TBP) interaction with various domains of progesterone receptor (PR) demonstrate that agonist-bound PR interaction with TBP via AF1 impacts the mobility of the C-terminal AF2.	Hydrogen	2-10	progesterone receptor	Homo sapiens	144-165
24909783-2	2014	A hydrogen/deuterium exchange (HDX) mass-spectrometry-based investigation of TATA box-binding protein (TBP) interaction with various domains of progesterone receptor (PR) demonstrate that agonist-bound PR interaction with TBP via AF1 impacts the mobility of the C-terminal AF2.	Hydrogen	2-10	progesterone receptor	Homo sapiens	167-169
24909783-2	2014	A hydrogen/deuterium exchange (HDX) mass-spectrometry-based investigation of TATA box-binding protein (TBP) interaction with various domains of progesterone receptor (PR) demonstrate that agonist-bound PR interaction with TBP via AF1 impacts the mobility of the C-terminal AF2.	Hydrogen	2-10	progesterone receptor	Homo sapiens	202-204
25861734-4	2015	In this paper, we propose two modifications of the ARIA protocol: (1) the softening of the force field together with adapted hydrogen radii, which is meaningful in the context of the log-harmonic potential with Bayesian weighting, (2) a procedure that automatically adjusts the violation tolerance used in the selection of active restraints, based on the fitting of the structure to the input data sets.	Hydrogen	125-133	endothelial cell surface expressed chemotaxis and apoptosis regulator	Homo sapiens	51-55
24951883-0	2014	Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3beta in the DRG in rats.	Hydrogen	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	127-136
24951883-10	2014	We also discovered that hydrogen-rich saline not 2.5 ml/kg but 5 and 10 ml/kg could dose-dependently attenuate mechanical and thermal hyperalgesia without affecting baseline nociceptive threshold, reduce expressions of inflammatory mediators (TNF-alpha, IL-1beta, and IL-6) and decrease NR1 trafficking mediated by GSK-3beta, and minimal effective concentration was observed to be higher than 10 mumol/L, namely peak concentration in arterial blood after administration of HRS 2.5 ml/kg without any influence on hyperalgesia.	Hydrogen	24-32	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	287-290
21918198-6	2011	As a consequence, H2-M/H2-O ratios significantly increased for CD8alpha(-) but not for CD8alpha(+) DCs.	Hydrogen	18-20	CD8 antigen, alpha chain	Mus musculus	63-71
21918198-6	2011	As a consequence, H2-M/H2-O ratios significantly increased for CD8alpha(-) but not for CD8alpha(+) DCs.	Hydrogen	23-25	CD8 antigen, alpha chain	Mus musculus	63-71
25740079-3	2015	Both homocysteine levels and endogenous HS(-) production are mainly regulated by two transsulfuration enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Hydrogen	40-45	cystathionase (cystathionine gamma-lyase)	Mus musculus	149-174
22058791-2	2011	Within the hydrogen-bonded network, R(4) (2)(22) ring motifs are stacked along [010].	Hydrogen	11-19	CD1a molecule	Homo sapiens	36-40
24951883-10	2014	We also discovered that hydrogen-rich saline not 2.5 ml/kg but 5 and 10 ml/kg could dose-dependently attenuate mechanical and thermal hyperalgesia without affecting baseline nociceptive threshold, reduce expressions of inflammatory mediators (TNF-alpha, IL-1beta, and IL-6) and decrease NR1 trafficking mediated by GSK-3beta, and minimal effective concentration was observed to be higher than 10 mumol/L, namely peak concentration in arterial blood after administration of HRS 2.5 ml/kg without any influence on hyperalgesia.	Hydrogen	24-32	glycogen synthase kinase 3 beta	Rattus norvegicus	315-324
24951883-11	2014	CONCLUSION: Our results indicated that antihyperalgesic effect of hydrogen-rich saline might depend predominantly on its ability to reverse NR1 trafficking via inhibition of GSK-3beta activity in DRG in a dose-dependent manner.	Hydrogen	66-74	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	140-143
24951883-11	2014	CONCLUSION: Our results indicated that antihyperalgesic effect of hydrogen-rich saline might depend predominantly on its ability to reverse NR1 trafficking via inhibition of GSK-3beta activity in DRG in a dose-dependent manner.	Hydrogen	66-74	glycogen synthase kinase 3 beta	Rattus norvegicus	174-183
24895096-1	2014	ZnIn(2)S(4) microspheres (ZIS MSs) were for the first time decorated with carbon quantum dots (CQDs) and platinum nanoparticles (NPs) as dual co-catalysts of for photocatalytic H(2) production.	Hydrogen	177-181	zinc finger RANBP2-type containing 2	Homo sapiens	26-29
21442609-6	2011	Specifically, the correct folding pattern of GSK3beta was disrupted in the K85M mutant, resulting in the loss of two key hydrogen bonds between K214 of FRATide and E290 and K292 of GSK3beta, respectively.	Hydrogen	121-129	glycogen synthase kinase 3 beta	Homo sapiens	45-53
25740079-3	2015	Both homocysteine levels and endogenous HS(-) production are mainly regulated by two transsulfuration enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Hydrogen	40-45	cystathionase (cystathionine gamma-lyase)	Mus musculus	176-179
26233131-3	2015	It is found that the associated fractionation factor Phi is correlated with the strength of the intramolecular hydrogen bonds.	Hydrogen	111-119	glucose-6-phosphate isomerase	Homo sapiens	53-56
21461930-0	2011	1H, 15N and 13C chemical shift assignments of the SH2 domain of human tensin2 (TENC1).	Hydrogen	0-2	tensin 2	Homo sapiens	70-77
21461930-0	2011	1H, 15N and 13C chemical shift assignments of the SH2 domain of human tensin2 (TENC1).	Hydrogen	0-2	tensin 2	Homo sapiens	79-84
24820620-0	2014	A role for hydrogen bonding in DNA recognition by the non-classical CCHHC type zinc finger, NZF-1.	Hydrogen	11-19	myelin transcription factor 1 like	Homo sapiens	92-97
25095616-8	2014	CONCLUSION: The reduced expressions of CBS and CSE may inhibit the H2 S signaling pathway, which might be one of the mechanisms underlying androgen deficiency-induced ED in rats.	Hydrogen	67-69	cystathionine gamma-lyase	Rattus norvegicus	47-50
26088037-5	2015	We conclude that the double-layer SnO is a promising material for visible-light driven photocatalysts for hydrogen evolution.	Hydrogen	106-114	strawberry notch homolog 1	Homo sapiens	34-37
24825430-1	2014	A multi-wall carbon nanotube supported Pd and Ni catalyst efficiently catalyzes the hydrogen storage of magnesium hydride prepared by HCS + MM.	Hydrogen	84-92	holocarboxylase synthetase	Homo sapiens	134-137
21756288-3	2011	We found that the most active compounds established three hydrogen bonds with the residues of the hinge region of GSK3beta, but some of the less active compounds have other binding modes.	Hydrogen	58-66	glycogen synthase kinase 3 beta	Homo sapiens	114-122
25899385-4	2015	Using hydrogen-deuterium exchange mass spectrometry, we demonstrate here that the Escherichia coli Y-family DNA polymerase DinB and its human ortholog DNA polymerase kappa undergo a conserved nucleotide-induced conformational change in the presence of undamaged DNA and the correct incoming nucleotide.	Hydrogen	6-14	DNA polymerase kappa	Homo sapiens	151-171
21211106-10	2011	Taken together, our data indicate that the hippocampal histaminergic system modulates the consolidation of fear extinction through a mechanism involving the H2-dependent activation of ERK signalling.	Hydrogen	157-159	mitogen activated protein kinase 3	Rattus norvegicus	184-187
24853947-2	2014	The single-crystal X-ray structures reveal that, in paramagnetic and electron paramagnetic resonance active 1 and reported diamagnetic [5]PF6, nearly planar monoanionic HL(-) coordinates to the metal ion via the N,N donors forming a five-membered chelate ring with hydrogen-bonded O-H   O function at the backbone of the ligand framework, as has also been reported in other metal complexes.	Hydrogen	265-273	sperm associated antigen 17	Homo sapiens	138-141
25882008-9	2015	At 1h in brain following ketamine only, the levels of TRH and TRH-like peptides were significantly increased in 52 instances (due to increased biosynthesis and/or decreased release) or decreased in five instances.	Hydrogen	3-5	thyrotropin releasing hormone	Rattus norvegicus	54-57
24914717-11	2014	However, based on our metods, the CRMYPC ligand has sufficient hydrogen bonding interactions with residues of the active side of neuraminidase-1 and can be therefore proposed as a potential inhibitor of neuraminidase-1.	Hydrogen	63-71	neuraminidase 1	Homo sapiens	129-144
24914717-11	2014	However, based on our metods, the CRMYPC ligand has sufficient hydrogen bonding interactions with residues of the active side of neuraminidase-1 and can be therefore proposed as a potential inhibitor of neuraminidase-1.	Hydrogen	63-71	neuraminidase 1	Homo sapiens	203-218
21489782-1	2011	Dark fermentative H2 production (DFHP) has received increasing attention in recent years due to its high H2 production rate (HPR) as well as the versatility of the substrates used in the process.	Hydrogen	18-20	haptoglobin-related protein	Homo sapiens	105-123
21489782-1	2011	Dark fermentative H2 production (DFHP) has received increasing attention in recent years due to its high H2 production rate (HPR) as well as the versatility of the substrates used in the process.	Hydrogen	18-20	haptoglobin-related protein	Homo sapiens	125-128
25882008-9	2015	At 1h in brain following ketamine only, the levels of TRH and TRH-like peptides were significantly increased in 52 instances (due to increased biosynthesis and/or decreased release) or decreased in five instances.	Hydrogen	3-5	thyrotropin releasing hormone	Rattus norvegicus	62-65
21721540-2	2011	Here, we demonstrate a metal-organic framework (MOF) having both hydrogen-bonding donor and acceptor sites that are quite effective for selective sorption.	Hydrogen	65-73	lysine acetyltransferase 8	Homo sapiens	23-52
26125623-5	2015	Structurally, hydrogen/deuterium exchange mass spectrometry (DXMS) studies revealed that solvent accessibility profiles of infectious and non-infectious autocatalytic recombinant PrP conformers are remarkably similar throughout their protease-resistant cores, except for two domains encompassing residues 91-115 and 144-163.	Hydrogen	14-22	prion protein	Mus musculus	179-182
21721540-3	2011	The MOF selectively interacts with hydroxylic guests in contrast to aprotic hydrogen-bonding guests and shows a sorption selectivity for protic H(2)O, MeOH, and EtOH guests.	Hydrogen	76-84	lysine acetyltransferase 8	Homo sapiens	4-7
24629044-10	2014	Moreover, H2 S could also reduce cigarette smoking-induced inflammation by inhibiting the phosphorylation of ERK 1/2, JNK and p38 MAPKs and negatively regulating NF-kappaB activation.	Hydrogen	10-12	mitogen activated protein kinase 3	Rattus norvegicus	109-116
26013958-0	2015	Inverted Fuel Cell: Room-Temperature Hydrogen Separation from an Exhaust Gas by Using a Commercial Short-Circuited PEM Fuel Cell without Applying any Electrical Voltage.	Hydrogen	37-45	mucin 1, cell surface associated	Homo sapiens	115-118
23875805-3	2014	The biocompatible E1/2 of ~+300 mV versus normal hydrogen electrode (NHE) allows powerful SOD mimics as mild oxidants and antioxidants (alike O2 (-)) to readily traffic electrons among reactive species and signaling proteins, serving as fine mediators of redox-based signaling pathways.	Hydrogen	49-57	solute carrier family 9 member C1	Homo sapiens	69-72
21655633-0	2011	Lithium-doped MOF impregnated with lithium-coated fullerenes: a hydrogen storage route for high gravimetric and volumetric uptakes at ambient temperatures.	Hydrogen	64-72	lysine acetyltransferase 8	Homo sapiens	14-17
21688374-0	2011	Benzylic ligand hydroxylation starting from a dicopper mu-eta2:eta2 peroxo intermediate: dramatic acceleration of the reaction by hydrogen-atom donors.	Hydrogen	130-138	DNA polymerase iota	Homo sapiens	58-62
26013958-1	2015	A short-circuited PEM fuel cell with a Nafion membrane has been evaluated in the room-temperature separation of hydrogen from exhaust gas streams.	Hydrogen	112-120	mucin 1, cell surface associated	Homo sapiens	18-21
21688374-0	2011	Benzylic ligand hydroxylation starting from a dicopper mu-eta2:eta2 peroxo intermediate: dramatic acceleration of the reaction by hydrogen-atom donors.	Hydrogen	130-138	DNA polymerase iota	Homo sapiens	63-67
25953903-3	2015	This substitution also attenuates exchange line broadening in the underlying beta2 and beta3a strands that is centered near a bifurcated main chain hydrogen bond interaction between these two strands.	Hydrogen	148-156	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	77-82
21469159-3	2011	The results obtained from the ONIOM geometry optimization and AIM analysis corroborated the presence of bridging water molecules that form hydrogen bonds with protein side chain of Thr138 and/or backbone of Gln185, and mediate interactions with inhibitors in the 10 selected GSK3beta-inhibitor complexes.	Hydrogen	139-147	glycogen synthase kinase 3 beta	Homo sapiens	275-283
24940221-2	2014	In the crystal, N-H O, C-H N and C-H O hydrogen bonds link the mol-ecules, forming chains along the b-axis direction.	Hydrogen	39-47	chimerin 1	Homo sapiens	23-36
24763696-0	2014	Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway.	Hydrogen	26-34	glycogen synthase kinase 3 beta	Rattus norvegicus	169-177
24763696-5	2014	In the present study, we aimed to evaluate whether hydrogen alleviates EBI after SAH, specifically neuronal apoptosis, partially via the Akt/GSK3beta signaling pathway.	Hydrogen	51-59	glycogen synthase kinase 3 beta	Rattus norvegicus	141-149
25974050-1	2015	The kinetics of hydrogen abstraction by five radicals (H, O((3)P), OH, CH3, and HO2) from methyl acetate (MA) is investigated theoretically in order to gain further understanding of certain aspects of the combustion chemistry of biodiesels, such as the effect of the ester moiety.	Hydrogen	16-24	heme oxygenase 2	Homo sapiens	80-83
24955162-5	2014	RESULTS: Fluid resuscitation with 2% hydrogen inhalation decreased serum creatinine, blood urea nitrogen, and neutrophil gelatinase-associated lipocalin.	Hydrogen	37-45	lipocalin 2	Rattus norvegicus	110-152
21464198-6	2011	The structure of ClW bound to GluA3 LBD exhibits a unique partially open hydrogen bonding structure that may be associated with these alternative kinetics.	Hydrogen	73-81	glutamate ionotropic receptor AMPA type subunit 3	Homo sapiens	30-35
25818978-0	2015	Hydrogen gas inhibits high-mobility group box 1 release in septic mice by upregulation of heme oxygenase 1.	Hydrogen	0-8	high mobility group box 1	Mus musculus	22-47
21443905-6	2011	These results, together with the structures of these compounds, suggest that hydrogen-bonding interactions between the polar amino or guanidino functions and complementary groups in the neuraminidase active site (e.g. Asp151, Glu 119) may be essential for strong inhibition of the neuraminidase enzyme and, in turn, the inhibition of influenza A virus replication.	Hydrogen	77-85	neuraminidase 1	Homo sapiens	186-199
24642259-4	2014	The structure reveals that the PDZ1-PLCbeta3 binding specificity is achieved by numerous hydrogen bonds and hydrophobic contacts with the last four PLCbeta3 residues contributing to specific interactions.	Hydrogen	89-97	phospholipase C beta 3	Homo sapiens	36-44
24642259-4	2014	The structure reveals that the PDZ1-PLCbeta3 binding specificity is achieved by numerous hydrogen bonds and hydrophobic contacts with the last four PLCbeta3 residues contributing to specific interactions.	Hydrogen	89-97	phospholipase C beta 3	Homo sapiens	148-156
21443905-6	2011	These results, together with the structures of these compounds, suggest that hydrogen-bonding interactions between the polar amino or guanidino functions and complementary groups in the neuraminidase active site (e.g. Asp151, Glu 119) may be essential for strong inhibition of the neuraminidase enzyme and, in turn, the inhibition of influenza A virus replication.	Hydrogen	77-85	neuraminidase 1	Homo sapiens	281-294
25818978-9	2015	However, therapy with H2 increased the survival rate and alleviated the severity of lung injury, reduced the HMGB1 level, and increased the HO-1 and Nrf2 levels in septic mice.	Hydrogen	22-24	high mobility group box 1	Mus musculus	109-114
25907383-2	2015	Our calculations show that when the two reactants approach each other, three prereaction complexes, RC1, RC2, and RC3, can be formed through van der Waals force or hydrogen bonding.	Hydrogen	164-172	neurogranin	Homo sapiens	114-117
21543258-2	2011	The stimulatory effect of hydrogen ion on these sensory nerves is generated by activation of two major types of ion channels expressed in these neurons: a rapidly activating and inactivating current mediated through ASICs, and a slow sustaining current via activation of TRPV1.	Hydrogen	26-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	271-276
25707580-9	2015	Western blot analysis showed that H2 attenuated ERK, p38 MAPK, and NF-kappaB signaling in mouse livers.	Hydrogen	34-36	mitogen-activated protein kinase 14	Mus musculus	53-56
21541840-10	2011	The docking results showed that the three important determinant residues Arg68, Val70 and Arg108 in catalase were binding with H(2)O(2) as they had strong hydrogen bonding contacts with the substrate.	Hydrogen	155-163	catalase	Bos taurus	100-108
23995979-2	2014	In this study, a Dehalobacter species strain TCP1 was isolated from a digester sludge sample, which is able to dechlorinate 2,4,6-trichlorophenol (2,4,6-TCP) to 4-monochlorophenol (4-MCP) with H2 as the sole electron donor and acetate as the carbon source.	Hydrogen	193-195	t-complex 1	Homo sapiens	45-49
25800379-5	2015	Hydrogen-bonding network analyses suggest that the elimination of the hydrogen bond between the linker ether and aspartate 321 (D321) of human trehalase is the key for lactulose and melibiose to avoid the hydrolyzation.	Hydrogen	0-8	trehalase	Homo sapiens	143-152
24589771-9	2014	RESULTS: NOX2 expression increased rapidly following TBI in male mice, with an early peak at 1h, followed by a second peak at 24h.	Hydrogen	93-95	cytochrome b-245, beta polypeptide	Mus musculus	9-13
20659751-5	2011	In conclusion, the cellular damage to the heart and liver is highest after 1h of transportation, Hsp27 and alphaB-crystallin play dissimilar roles and show tissue-specific response in different tissues during transportation.	Hydrogen	75-77	crystallin alpha B	Sus scrofa	107-124
25800379-5	2015	Hydrogen-bonding network analyses suggest that the elimination of the hydrogen bond between the linker ether and aspartate 321 (D321) of human trehalase is the key for lactulose and melibiose to avoid the hydrolyzation.	Hydrogen	70-78	trehalase	Homo sapiens	143-152
25712529-2	2015	The fast exponential decay of (3)B* (life-time tauT   200 ns) is accompanied by hydrogen atom abstraction from E with a formation of BH  and a polymer free radical R .	Hydrogen	80-88	solute carrier family 6 member 6	Homo sapiens	47-51
21437341-0	2011	Effects of varying water adsorption on a Cu3(BTC)2 metal-organic framework (MOF) as studied by 1H and 13C solid-state NMR spectroscopy.	Hydrogen	95-97	lysine acetyltransferase 8	Homo sapiens	76-79
21488645-5	2011	The HScO(0,+) structures are obtained by covalent or dative interaction of hydrogen and ScO(0,+).	Hydrogen	75-83	ETHE1 persulfide dioxygenase	Homo sapiens	4-8
24492486-0	2014	Ag2S/g-C3N4 composite photocatalysts for efficient Pt-free hydrogen production.	Hydrogen	59-67	angiotensin II receptor type 1	Homo sapiens	0-4
24492486-5	2014	The results demonstrated that the photocatalytic H2-production activity of g-C3N4 can be remarkably increased by the combination of Ag2S.	Hydrogen	49-51	angiotensin II receptor type 1	Homo sapiens	132-136
24492486-6	2014	The optimal Ag2S loading was found to be 5 wt%, giving a H2 production of 10 mumol h(-1), around 100 times that of pure g-C3N4.	Hydrogen	57-59	angiotensin II receptor type 1	Homo sapiens	12-16
24492486-8	2014	This work showed the possibility for utilization of Ag2S or Ag/Ag2S as a substitute for Pt in the photocatalytic production of H2 using g-C3N4.	Hydrogen	127-129	angiotensin II receptor type 1	Homo sapiens	52-56
24492486-8	2014	This work showed the possibility for utilization of Ag2S or Ag/Ag2S as a substitute for Pt in the photocatalytic production of H2 using g-C3N4.	Hydrogen	127-129	angiotensin II receptor type 1	Homo sapiens	63-67
25799018-6	2015	The nitride is also catalytically active in sour methanation of syngas with &gt;80% CO and H2 conversion at 723 K. Our formulated route for the synthesis of 3R-MoN2 is at a moderate pressure of 3.5 GPa and, thus, is feasible for industrial-scale catalyst production.	Hydrogen	91-93	MON2 homolog, regulator of endosome-to-Golgi trafficking	Homo sapiens	160-164
24528177-4	2014	The conformation beta2 is stabilized by the intramolecular N-H   N hydrogen bond and predominates in the low polar environment.	Hydrogen	67-75	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	17-22
21431140-4	2011	These photochemical products most likely form, after hydrogen bonding between C(24)H(12) and H(2)O, through ionization of the PAH and subsequent reactivity with water upon irradiation.	Hydrogen	53-61	phenylalanine hydroxylase	Homo sapiens	126-129
25666614-7	2015	Hydrogen/deuterium exchange mass spectrometry revealed that RGS14 is a very dynamic protein that undergoes allosteric conformational changes when inactive Galphai1-GDP binds the GPR motif.	Hydrogen	0-8	regulator of G protein signaling 14	Homo sapiens	60-65
21528977-2	2011	Using density functional theory (DFT) at the GGA-PBE level, the chemical binding of atomic hydrogen to pyrene is found to be exothermic by up to 1.6 eV with a strong site dependence.	Hydrogen	91-99	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	49-52
23943053-5	2014	The hydrogen bond network readily collapses if worms are subjected to hypoxic conditions, likely via activation of the parasite tegument-associated neutral sphingomyelinase, and consequent excessive SM hydrolysis.	Hydrogen	4-12	sphingomyelin phosphodiesterase 2	Homo sapiens	148-172
25666614-8	2015	Pure RGS14 forms a ternary complex with Galphao-AlF4(-) and an AlF4(-)-insensitive mutant (G42R) of Galphai1-GDP, as observed by size exclusion chromatography and differential hydrogen/deuterium exchange.	Hydrogen	176-184	regulator of G protein signaling 14	Homo sapiens	5-10
21295090-6	2011	Computer modeling verified that MT1-AF7p binds to the MT-loop region of MT1-MMP and interacts with MT1-MMP through hydrogen bonding and hydrophobic interactions.	Hydrogen	115-123	matrix metallopeptidase 14	Homo sapiens	99-106
25746665-6	2015	Importantly, hydrogen-rich saline treatment significantly inhibited the activation of p-p38 and NF-kappaB while suppressing the production of several proinflammatory mediators.	Hydrogen	13-21	mitogen activated protein kinase 14	Rattus norvegicus	88-91
21711801-3	2011	Increasing the H2 content leads to an increase in the growth rate, a reduction in the areal density of the GaN NWs and a suppression of the underlying amorphous (alpha)-like GaN layer which occurs without H2.	Hydrogen	15-17	gigaxonin	Homo sapiens	107-110
21711801-3	2011	Increasing the H2 content leads to an increase in the growth rate, a reduction in the areal density of the GaN NWs and a suppression of the underlying amorphous (alpha)-like GaN layer which occurs without H2.	Hydrogen	15-17	gigaxonin	Homo sapiens	174-177
21711801-4	2011	The increase in growth rate with H2 content is a direct consequence of the reaction of Ga with H2 which leads to the formation of Ga hydride that reacts efficiently with NH3 at the top of the GaN NWs.	Hydrogen	33-35	gigaxonin	Homo sapiens	192-195
21711801-4	2011	The increase in growth rate with H2 content is a direct consequence of the reaction of Ga with H2 which leads to the formation of Ga hydride that reacts efficiently with NH3 at the top of the GaN NWs.	Hydrogen	95-97	gigaxonin	Homo sapiens	192-195
24270708-8	2014	We suggest that further reactive processes may be responsible for part of this deuterium loss, indicating that PAHs adsorbed on hydrogenated carbonaceous grains in warm interstellar environments may serve as a route to release H2 as well as forming superhydrogenated PAH species.	Hydrogen	227-229	phenylalanine hydroxylase	Homo sapiens	111-114
24417681-3	2014	Unlike one-dimensional binders, hyperbranched network structure of beta-CDp presents multidimensional hydrogen-bonding interactions with Si particles and therefore offers robust contacts between both components.	Hydrogen	102-110	cut like homeobox 1	Homo sapiens	72-75
24392950-9	2014	In all the structures, the Cu-X   HN type of hydrogen bonds involving the metal halide ion as acceptor and the pyrrolic NH as donor are present with the Cu-X   H angles, which deviate from the favored 90 , as observed in their solid state structures.	Hydrogen	45-53	cut like homeobox 1	Homo sapiens	27-31
24392950-9	2014	In all the structures, the Cu-X   HN type of hydrogen bonds involving the metal halide ion as acceptor and the pyrrolic NH as donor are present with the Cu-X   H angles, which deviate from the favored 90 , as observed in their solid state structures.	Hydrogen	45-53	cut like homeobox 1	Homo sapiens	153-157
24055376-5	2014	As seen in the crystal structure of THp-(1-43) complexed with 14-3-3gamma, the region surrounding pSer19 adopts an extended conformation in the bound state, whereas THp-(1-43) adopts a bent conformation when free in solution, with higher content of secondary structure and higher number of internal hydrogen bonds.	Hydrogen	299-307	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Homo sapiens	62-73
24183425-5	2014	Owing to sensitizing with a narrow bandgap material like Ag2S and the homogeneous distribution of the Ag2S NP heterojunction structures over the surface of the TNAs, the synthesized nanocomposite samples exhibited remarkable capability to absorb visible light and showed a significant enhancement in the photocatalytic efficiency of hydrogen generation.	Hydrogen	333-341	angiotensin II receptor type 1	Homo sapiens	102-106
24183425-6	2014	Under visible light illumination (100mW/cm(2)), a maximum photoconversion efficiency of 1.21% and the highest hydrogen production rate of 1.13mL/cm(2)h were obtained from the TNA electrodes sensitized with Ag2S NPs.	Hydrogen	110-118	angiotensin II receptor type 1	Homo sapiens	206-210
24140975-5	2013	The molecular docking study further revealed that the ACEI activity of IW-11 is mainly attributed to the formation of hydrogen bonds between the N-terminal residue of IW-11 and the S1 pocket (Ala354 and Tyr523) and the S2" region (His513 and His353) of ACE.	Hydrogen	118-126	angiotensin-converting enzyme	Pelodiscus sinensis	54-57
24147985-0	2013	NMR studies of protonation and hydrogen bond states of internal aldimines of pyridoxal 5"-phosphate acid-base in alanine racemase, aspartate aminotransferase, and poly-L-lysine.	Hydrogen	31-39	pyridoxal phosphatase	Homo sapiens	77-99
24191053-1	2013	Kinetic folding of the large two-domain maltose binding protein (MBP; 370 residues) was studied at high structural resolution by an advanced hydrogen-exchange pulse-labeling mass-spectrometry method (HX MS).	Hydrogen	141-149	myelin basic protein	Homo sapiens	65-68
24100137-2	2013	Crystal structures reported here reveal a surprising Trp112 native conformation stabilized by a specific Gln114-centered hydrogen bond network in the AKR1B10 holoenzyme, and suggest that AKR1B1 inhibitors could retain their binding affinities toward AKR1B10 by inducing Trp112 flip to result in an "AKR1B1-like" active site in AKR1B10, while selective AKR1B10 inhibitors can take advantage of the broader active site of AKR1B10 provided by the native Trp112 side-chain orientation.	Hydrogen	121-129	aldo-keto reductase family 1 member B10	Homo sapiens	150-157
24100137-2	2013	Crystal structures reported here reveal a surprising Trp112 native conformation stabilized by a specific Gln114-centered hydrogen bond network in the AKR1B10 holoenzyme, and suggest that AKR1B1 inhibitors could retain their binding affinities toward AKR1B10 by inducing Trp112 flip to result in an "AKR1B1-like" active site in AKR1B10, while selective AKR1B10 inhibitors can take advantage of the broader active site of AKR1B10 provided by the native Trp112 side-chain orientation.	Hydrogen	121-129	aldo-keto reductase family 1 member B10	Homo sapiens	250-257
24100137-2	2013	Crystal structures reported here reveal a surprising Trp112 native conformation stabilized by a specific Gln114-centered hydrogen bond network in the AKR1B10 holoenzyme, and suggest that AKR1B1 inhibitors could retain their binding affinities toward AKR1B10 by inducing Trp112 flip to result in an "AKR1B1-like" active site in AKR1B10, while selective AKR1B10 inhibitors can take advantage of the broader active site of AKR1B10 provided by the native Trp112 side-chain orientation.	Hydrogen	121-129	aldo-keto reductase family 1 member B10	Homo sapiens	250-257
24100137-2	2013	Crystal structures reported here reveal a surprising Trp112 native conformation stabilized by a specific Gln114-centered hydrogen bond network in the AKR1B10 holoenzyme, and suggest that AKR1B1 inhibitors could retain their binding affinities toward AKR1B10 by inducing Trp112 flip to result in an "AKR1B1-like" active site in AKR1B10, while selective AKR1B10 inhibitors can take advantage of the broader active site of AKR1B10 provided by the native Trp112 side-chain orientation.	Hydrogen	121-129	aldo-keto reductase family 1 member B10	Homo sapiens	250-257
24100137-2	2013	Crystal structures reported here reveal a surprising Trp112 native conformation stabilized by a specific Gln114-centered hydrogen bond network in the AKR1B10 holoenzyme, and suggest that AKR1B1 inhibitors could retain their binding affinities toward AKR1B10 by inducing Trp112 flip to result in an "AKR1B1-like" active site in AKR1B10, while selective AKR1B10 inhibitors can take advantage of the broader active site of AKR1B10 provided by the native Trp112 side-chain orientation.	Hydrogen	121-129	aldo-keto reductase family 1 member B10	Homo sapiens	250-257
23831226-6	2013	Determination of the oxidized b5R structure, including the hydrogen atoms, determined at 0.78A resolution revealed the details of a hydrogen-bonding network from the N5 atom of FAD to His49 via Thr66.	Hydrogen	59-67	cytochrome b5 reductase 3	Homo sapiens	30-33
23831226-6	2013	Determination of the oxidized b5R structure, including the hydrogen atoms, determined at 0.78A resolution revealed the details of a hydrogen-bonding network from the N5 atom of FAD to His49 via Thr66.	Hydrogen	132-140	cytochrome b5 reductase 3	Homo sapiens	30-33
24076403-0	2013	Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	55-63	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	14-42
24257230-8	2013	In addition, hydrogen-rich saline also suppressed the expression of p38-mitogen-activated protein kinase (p38MAPK) and brain-derived neurotrophic factor (BDNF) in the spinal cord by 7 days post-chronic constriction injury (p&lt;0.01, p&lt;0.01, respectively), but had no effect on P2X4R (p&gt;0.05), an ATP receptor.	Hydrogen	13-21	mitogen activated protein kinase 14	Rattus norvegicus	68-104
24257230-8	2013	In addition, hydrogen-rich saline also suppressed the expression of p38-mitogen-activated protein kinase (p38MAPK) and brain-derived neurotrophic factor (BDNF) in the spinal cord by 7 days post-chronic constriction injury (p&lt;0.01, p&lt;0.01, respectively), but had no effect on P2X4R (p&gt;0.05), an ATP receptor.	Hydrogen	13-21	mitogen activated protein kinase 14	Rattus norvegicus	106-113
24257230-9	2013	CONCLUSION: Intrathecal injection of hydrogen-rich saline can decrease oxidative stress and the expression of p38MAPK and BDNF that may contribute to the elevated threshold of neuropathic pain in rat CCI model.	Hydrogen	37-45	mitogen activated protein kinase 14	Rattus norvegicus	110-117
24026578-0	2013	Conformational analysis and intramolecular hydrogen bonding of cis-3-aminoindan-1-ol: a quantum chemical study.	Hydrogen	43-51	suppressor of cytokine signaling 3	Homo sapiens	63-68
23848594-8	2013	The Asn198 is located in the amphipathic cavity comprising Leu869(IN), Glu868(IN), Thr872(IN), Tyr197(AurA) and Tyr199(AurA) and the interactions mediated via hydrogen bonds are important to stabilize the Aurora-A(G198N) - INCENP complex.	Hydrogen	159-167	aurora kinase A	Homo sapiens	205-210
24073894-2	2013	Interestingly, there are two spectrally distinct hydrogen-bond (H-bond) configurations in aqueous NaPF6 solutions: water molecules that are H-bonded to PF6(-) (ODA) or other water molecules (ODW).	Hydrogen	49-57	sperm associated antigen 17	Homo sapiens	100-103
23770402-6	2013	However, the long pentadecyl alkyl chain of CTPB produces a barrier and reducing the chance of forming hydrogen bonding with p300.	Hydrogen	103-111	E1A binding protein p300	Homo sapiens	125-129
23996000-1	2013	X-ray structural and mutational analyses have shown that bovine heart cytochrome c oxidase (CcO) pumps protons electrostatically through a hydrogen bond network using net positive charges created upon oxidation of a heme iron (located near the hydrogen bond network) for O2 reduction.	Hydrogen	244-252	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	70-90
23996000-1	2013	X-ray structural and mutational analyses have shown that bovine heart cytochrome c oxidase (CcO) pumps protons electrostatically through a hydrogen bond network using net positive charges created upon oxidation of a heme iron (located near the hydrogen bond network) for O2 reduction.	Hydrogen	244-252	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	92-95
23707248-5	2013	We further confirmed that green light illumination for 1h in the dark period suppressed orexin neuronal activity in vivo using c-Fos expression.	Hydrogen	55-57	hypocretin	Mus musculus	88-94
23707248-6	2013	Continuous 1h silencing of orexin neurons in freely moving orexin-tTA; TetO ArchT mice during the night (the active period, 20:00-21:00) significantly increased total time spent in slow-wave sleep (SWS) and decreased total wake time.	Hydrogen	11-13	hypocretin	Mus musculus	27-33
23707248-6	2013	Continuous 1h silencing of orexin neurons in freely moving orexin-tTA; TetO ArchT mice during the night (the active period, 20:00-21:00) significantly increased total time spent in slow-wave sleep (SWS) and decreased total wake time.	Hydrogen	11-13	hypocretin	Mus musculus	59-65
23893931-7	2013	However, two hydrogen bonded barricades formed as ARG28-GLY297-GLY295-GLY131 and TRP129-ARG28-ALA130-LEU29-TRP129 obstruct the B3N from exploring the B channels in HDAC3.	Hydrogen	13-21	histone deacetylase 3	Homo sapiens	164-169
23712771-5	2013	Docking results showed that binding between ligands and ERbeta was stabilized by hydrogen bond and hydrophobic interactions.	Hydrogen	81-89	estrogen receptor 2	Homo sapiens	56-62
23065337-0	2013	1H, 13C, and 15N backbone resonance assignments of the connexin43 carboxyl terminal domain attached to the 4th transmembrane domain in detergent micelles.	Hydrogen	0-2	gap junction protein alpha 1	Homo sapiens	55-65
23070844-0	2013	1H, 15N and 13C backbone resonance assignments of the TPR1 and TPR2A domains of mouse STI1.	Hydrogen	0-2	tetratricopeptide repeat domain 1	Mus musculus	54-58
23179059-0	2013	1H, 13C and 15N resonance assignments of human parvulin 17.	Hydrogen	0-2	peptidylprolyl cis/trans isomerase, NIMA-interacting 4	Homo sapiens	47-58
21711801-5	2011	Moreover, the reduction in the areal density of the GaN NWs and suppression of the alpha-like GaN layer is attributed to the reaction of H2 with Ga in the immediate vicinity of the Au NPs.	Hydrogen	137-139	gigaxonin	Homo sapiens	52-55
21711801-5	2011	Moreover, the reduction in the areal density of the GaN NWs and suppression of the alpha-like GaN layer is attributed to the reaction of H2 with Ga in the immediate vicinity of the Au NPs.	Hydrogen	137-139	gigaxonin	Homo sapiens	94-97
21247217-5	2011	Our simulations show that RPAR binds NRP-1 through specific interactions of the RPAR C-terminus: three hydrogen bonds and a salt bridge anchor the ligand in the receptor pocket.	Hydrogen	103-111	neuropilin 1	Homo sapiens	37-42
21250662-0	2011	Alteration of hydrogen bonding in the vicinity of histidine 48 disrupts millisecond motions in RNase A.	Hydrogen	14-22	ribonuclease A family member 1, pancreatic	Homo sapiens	95-102
21250662-3	2011	These studies suggested that RNase A relies on an intricate network of hydrogen bonding interactions involved in propagating functionally relevant, long-range ms motions to the catalytic site of the enzyme.	Hydrogen	71-79	ribonuclease A family member 1, pancreatic	Homo sapiens	29-36
21302953-2	2011	X-ray crystal structures revealed unique interactions for a benzoxazole template in addition to the conserved hydrogen bonds with the catalytic machinery of sEH.	Hydrogen	110-118	epoxide hydrolase 2	Homo sapiens	157-160
21237148-5	2011	Pretreatment with IL-10 (10-100ng, intracerebroventricularly) 1h before intravenous LPS significantly reduced the LPS-induced changes in extracellular glutamate, hydroxyl radicals, and PGE(2) in the hypothalamus and fever, but not the increased levels of TNF-alpha in rabbits.	Hydrogen	62-64	interleukin-10	Oryctolagus cuniculus	18-23
21180693-0	2011	BET specific surface area and pore structure of MOFs determined by hydrogen adsorption at 20 K. Low-pressure high-resolution hydrogen adsorption for the metal-organic framework MIL-101 are measured at 19.5 K and pressures below 57 kPa.	Hydrogen	67-75	delta/notch like EGF repeat containing	Homo sapiens	0-3
21180693-0	2011	BET specific surface area and pore structure of MOFs determined by hydrogen adsorption at 20 K. Low-pressure high-resolution hydrogen adsorption for the metal-organic framework MIL-101 are measured at 19.5 K and pressures below 57 kPa.	Hydrogen	125-133	delta/notch like EGF repeat containing	Homo sapiens	0-3
21180693-1	2011	The BET specific surface area and micropore volume are determined and compared to results from nitrogen adsorption at 77 K. Steps in the hydrogen adsorption isotherm are correlated to the pore structure of MIL-101.	Hydrogen	137-145	delta/notch like EGF repeat containing	Homo sapiens	4-7
21035569-2	2011	In this article, we characterized individual residues in both non-myristoylated (non-myr) and myristoylated (myr) neuronal calcium sensor-1 (NCS-1) that access alternate states by measuring nonlinear temperature dependence of the backbone amide-proton (1H(N)) chemical shifts.	Hydrogen	253-255	neuronal calcium sensor 1	Homo sapiens	114-139
21035569-2	2011	In this article, we characterized individual residues in both non-myristoylated (non-myr) and myristoylated (myr) neuronal calcium sensor-1 (NCS-1) that access alternate states by measuring nonlinear temperature dependence of the backbone amide-proton (1H(N)) chemical shifts.	Hydrogen	253-255	neuronal calcium sensor 1	Homo sapiens	141-146
21190891-2	2011	Potential of hydrogen bond is the function which relates its energy to geometrical parameters of hydrogen bridge: its length R(O...O) and angles between direction O...O and OH group [phi (H-O...O)] and/or lone pair of proton accepting oxygen atom [chi(-O...O)].	Hydrogen	13-21	glucose-6-phosphate isomerase	Homo sapiens	183-186
21190891-2	2011	Potential of hydrogen bond is the function which relates its energy to geometrical parameters of hydrogen bridge: its length R(O...O) and angles between direction O...O and OH group [phi (H-O...O)] and/or lone pair of proton accepting oxygen atom [chi(-O...O)].	Hydrogen	97-105	glucose-6-phosphate isomerase	Homo sapiens	183-186
21522869-2	2011	Intra-molecular C-H N and C-H O hydrogen bonds occur.	Hydrogen	32-40	chimerin 1	Homo sapiens	16-29
21042611-3	2011	As a result, the networks formed by the hydrogen-bonded molecules presented interesting properties as a function of eta, including small-world patterns and percolation transitions.	Hydrogen	40-48	endothelin receptor type A	Homo sapiens	116-119
21141952-1	2011	Here we report the first in situ high-pressure study of sodium amide (NaNH(2)) as an agent in potential hydrogen storage applications by using combined Raman and infrared (IR) spectroscopies at room temperature and pressures up to ~16 GPa.	Hydrogen	104-112	neuraminidase 1	Homo sapiens	70-74
20979085-1	2011	Cyclic octapeptides composed of alpha-amino acids alternated with cis-3-aminocycloalkanecarboxylic acids, self-assemble as drumlike dimers through beta-sheet-like, backbone-to-backbone hydrogen bonding.	Hydrogen	185-193	suppressor of cytokine signaling 3	Homo sapiens	66-71
21217827-4	2010	The experimental reduction in enzyme activity in the AKR1C2 variants F46Y and L172Q, as determined by Takahashi et al., is predicted to be due to increased instability in cofactor binding, caused by disruptions to the hydrogen bonds between NADP and AKR1C2, resulting from the insertion of polar residues into largely non-polar environments near the site of cofactor binding.	Hydrogen	218-226	aldo-keto reductase family 1 member C2	Homo sapiens	53-59
21098298-4	2010	Using molecular dynamics simulations with three force fields we show that spontaneous formation of two ordered one-dimensional water wires in the pore between the two sheets of the Sup35 protofilaments results in long-lived structures, which are stabilized by a network of hydrogen bonds between the water molecules in the wires and the polar side chains in the beta-sheet.	Hydrogen	273-281	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	181-186
21041096-4	2010	The preferential hydrogen bonding network formation between His-12 and His-119 of RNase A with the polar carboxylic and amino groups of these compounds has been evidenced from the docking studies.	Hydrogen	17-25	ribonuclease A family member 1, pancreatic	Homo sapiens	82-89
20875812-6	2010	For analysis after 1h at 22 C, the addition of NPM decreased the loss of ACTH from 15+-2% to 2+-2% (p&lt;0.002).	Hydrogen	19-21	nucleophosmin 1	Homo sapiens	47-50
20937275-0	2010	NMR study of hydrogen exchange during the B-Z transition of a DNA duplex induced by the Zalpha domains of yatapoxvirus E3L.	Hydrogen	13-21	double-strand RNA-binding protein	Vaccinia virus	119-122
20937275-4	2010	Here we have performed NMR hydrogen exchange experiments on the complexes between yabZalpha(E3L) and d(CGCGCG)(2) with a variety of protein-to-DNA molar ratios.	Hydrogen	27-35	double-strand RNA-binding protein	Vaccinia virus	92-95
20942406-1	2010	Amide hydrogen/deuterium exchange (HDX) rate constants of bovine ubiquitin in an ammonium acetate solution containing 1% of the electrospray ionization (ESI) "supercharging" reagent m-nitrobenzyl alcohol (m-NBA) were obtained using top-down, electron transfer dissociation (ETD) tandem mass spectrometry (MS).	Hydrogen	6-14	ubiquitin	Bos taurus	65-74
20685848-4	2010	We calculated the hydrogen bonding energies between the compounds and the GPR120 model.	Hydrogen	18-26	free fatty acid receptor 4	Mus musculus	74-80
20849073-3	2010	The entropy of activation (DeltaS( ) = -25.3 +- 2.5 cal mol(-1) K(-1)) and the kinetic isotope effect of 7.2 supported a bimolecular associative mechanism in the rate-determining hydrogen atom transfer from Ir(ttp)H to TEMPO.	Hydrogen	179-187	ZFP36 ring finger protein	Homo sapiens	210-213
20947024-4	2010	Both RRM1 in RRM1-RNA and RRM2 in RRM1/2-RNA complexes use similar principles to target UGU(U/G) elements, with recognition mediated by face-to-edge stacking and water-mediated hydrogen-bonding networks.	Hydrogen	177-185	ribonucleotide reductase catalytic subunit M1	Homo sapiens	5-9
20947024-4	2010	Both RRM1 in RRM1-RNA and RRM2 in RRM1/2-RNA complexes use similar principles to target UGU(U/G) elements, with recognition mediated by face-to-edge stacking and water-mediated hydrogen-bonding networks.	Hydrogen	177-185	ribonucleotide reductase catalytic subunit M1	Homo sapiens	13-17
20947024-4	2010	Both RRM1 in RRM1-RNA and RRM2 in RRM1/2-RNA complexes use similar principles to target UGU(U/G) elements, with recognition mediated by face-to-edge stacking and water-mediated hydrogen-bonding networks.	Hydrogen	177-185	ribonucleotide reductase catalytic subunit M1	Homo sapiens	34-40
20623209-0	2010	1H, 15N and 13C chemical shift assignments of the Cdt1 binding domain of human Mcm6.	Hydrogen	0-2	chromatin licensing and DNA replication factor 1	Homo sapiens	50-54
25733631-4	2015	DESIGN: Heat map analysis was performed to identify correlations between 1H nuclear magnetic resonance (NMR) spectral regions and SSB intakes in participants of the National Adult Nutrition Survey (n = 565).	Hydrogen	73-75	small RNA binding exonuclease protection factor La	Homo sapiens	130-133
25916785-0	2015	[Role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion injury in rats].	Hydrogen	30-38	forkhead box O3	Rattus norvegicus	9-15
25916785-1	2015	OBJECTIVE: To investigate the role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion (I/R) injury in rats.	Hydrogen	59-67	forkhead box O3	Rattus norvegicus	38-44
25916785-12	2015	CONCLUSION: Hydrogen-rich saline can attenuate global cerebral I/R injure through inhibiting JNK, reducing the expression of FOXO3a.	Hydrogen	12-20	forkhead box O3	Rattus norvegicus	125-131
25183402-11	2015	Structure-activity relationship analysis showed that CYP2B6 and CYP3A4 inducers are bulky lipophilic molecules with a higher number of heavy atoms and a lower number of hydrogen bond donors.	Hydrogen	169-177	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	53-59
25532047-1	2015	The intermolecular complex with a CHN hydrogen bond formed by 1,1-dinitroethane (DNE) and 2,4,6-trimethylpyridine (collidine) dissolved in CD2Cl2 was studied experimentally by (1)H NMR spectroscopy at 180-300 K. Equilibrium between the molecular CH   N form and the zwitterionic C(-)/HN(+) form was detected in the slow exchange regime in the NMR time scale.	Hydrogen	38-46	chimerin 1	Homo sapiens	246-252
25624750-5	2015	Our docking study showed that ALS, MLN8054, and VX-680 preferentially bound to AURKA over AURKB via hydrogen bond formation, charge interaction, and pi-pi stacking.	Hydrogen	100-108	aurora kinase A	Homo sapiens	79-84
26422353-1	2015	OBJECTIVE: The purpose of this study was to investigate the effects of intraperitoneal hydrogen (H2) injection on the mRNA expression levels of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) as well as the serum malondialdehyde (MDA) level in a rabbit model of limb ischemia-reperfusion (I/R)-induced skeletal muscle injury.	Hydrogen	87-95	nitric oxide synthase, inducible	Oryctolagus cuniculus	144-175
26422353-1	2015	OBJECTIVE: The purpose of this study was to investigate the effects of intraperitoneal hydrogen (H2) injection on the mRNA expression levels of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) as well as the serum malondialdehyde (MDA) level in a rabbit model of limb ischemia-reperfusion (I/R)-induced skeletal muscle injury.	Hydrogen	87-95	nitric oxide synthase, inducible	Oryctolagus cuniculus	177-181
26422353-1	2015	OBJECTIVE: The purpose of this study was to investigate the effects of intraperitoneal hydrogen (H2) injection on the mRNA expression levels of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) as well as the serum malondialdehyde (MDA) level in a rabbit model of limb ischemia-reperfusion (I/R)-induced skeletal muscle injury.	Hydrogen	97-99	nitric oxide synthase, inducible	Oryctolagus cuniculus	144-175
26422353-1	2015	OBJECTIVE: The purpose of this study was to investigate the effects of intraperitoneal hydrogen (H2) injection on the mRNA expression levels of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) as well as the serum malondialdehyde (MDA) level in a rabbit model of limb ischemia-reperfusion (I/R)-induced skeletal muscle injury.	Hydrogen	97-99	nitric oxide synthase, inducible	Oryctolagus cuniculus	177-181
26422353-8	2015	Intraperitoneal injection of H2 can down-regulate iNOS mRNA expression and up-regulate eNOS mRNA expression in the I/R process, suggesting a protective effect of H2 in I/R-induced skeletal muscle injury.	Hydrogen	29-31	nitric oxide synthase, inducible	Oryctolagus cuniculus	50-54
25373502-6	2015	The complexes were stabilized inside a large LOX-1 cavity by establishing a network of hydrogen bonds and steric interactions.	Hydrogen	87-95	oxidized low density lipoprotein receptor 1	Homo sapiens	45-50
20655112-0	2010	Solution 1H NMR characterization of substrate-free C. diphtheriae heme oxygenase: pertinence for determining magnetic axes in paramagnetic substrate complexes.	Hydrogen	9-11	biliverdin-producing heme oxygenase	Corynebacterium diphtheriae	66-80
20660185-0	2010	Local conformational stability of HIV-1 gp120 in unliganded and CD4-bound states as defined by amide hydrogen/deuterium exchange.	Hydrogen	101-109	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	40-45
20660185-4	2010	Here we use amide hydrogen/deuterium exchange coupled to mass spectrometry to provide quantifications of local conformational stability for HIV-1 gp120 in unliganded and CD4-bound states.	Hydrogen	18-26	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	146-151
23715206-4	2013	[(Ph2HP)2BH2][BAr(F)4] reacts with RhH(PPh3)3, by elimination of H2, forming [Rh(kappa(1),eta-PPh2BH2 PPh2H)(PPh3)2][BAr(F)4] which shows a beta-B-agostic interaction from the resulting base stabilised phosphino-borane ligand.	Hydrogen	10-12	endothelin receptor type A	Homo sapiens	90-93
26118050-2	2015	It was set that the starting dose of enzyme lactase must depend on the degree of severity of displays of transient lactase insufficiency, taking into account the indexes of hydrogen respiratory test.	Hydrogen	173-181	lactase	Homo sapiens	44-51
23715401-1	2013	New functionally diverse urea-derived MOF hydrogen-bond-donating heterogeneous catalysts were achieved via postsynthetic modification, which exhibit excellent catalytic activity and very broad substrate scopes for the Friedel-Crafts alkylation reactions.	Hydrogen	42-50	lysine acetyltransferase 8	Homo sapiens	38-41
21160910-1	2010	BACKGROUND: Sodium/hydrogen exchanger-1 (NHE-1) contributes to maintaining intracellular pH (pHi).	Hydrogen	19-27	glucose-6-phosphate isomerase	Homo sapiens	93-96
25469552-0	2014	Unprecedented chemical reactivity of a paramagnetic endohedral metallofullerene La@C(s)-C82 that leads hydrogen addition in the 1,3-dipolar cycloaddition reaction.	Hydrogen	103-111	lactase	Homo sapiens	80-84
23907820-9	2013	An antiparallel beta-sheet-type aggregate consisting of an infinite one-dimensional hydrogen-bonding network of amide groups and pi-stacking of PdCl(dpb) moieties was observed in the supramolecular gel fiber of L-2, even though discrete dimers are assembled through hydrogen bonding in the thermodynamically stable single crystal of L-2.	Hydrogen	84-92	immunoglobulin kappa variable 3-15	Homo sapiens	211-214
23907820-9	2013	An antiparallel beta-sheet-type aggregate consisting of an infinite one-dimensional hydrogen-bonding network of amide groups and pi-stacking of PdCl(dpb) moieties was observed in the supramolecular gel fiber of L-2, even though discrete dimers are assembled through hydrogen bonding in the thermodynamically stable single crystal of L-2.	Hydrogen	84-92	immunoglobulin kappa variable 3-15	Homo sapiens	333-336
23907820-9	2013	An antiparallel beta-sheet-type aggregate consisting of an infinite one-dimensional hydrogen-bonding network of amide groups and pi-stacking of PdCl(dpb) moieties was observed in the supramolecular gel fiber of L-2, even though discrete dimers are assembled through hydrogen bonding in the thermodynamically stable single crystal of L-2.	Hydrogen	266-274	immunoglobulin kappa variable 3-15	Homo sapiens	211-214
25469552-1	2014	Synthesizing unprecedented diamagnetic adducts of an endohedral metallofullerene was achieved by using 1,3-dipolar cycloaddition reaction of paramagnetic La@C(s)-C82 with a simultaneous hydrogen addition.	Hydrogen	186-194	lactase	Homo sapiens	154-158
25327985-5	2014	Spin mixing at LACs allows one to polarize substrates at high fields as well; the achievable NMR enhancements are around 360 for the ortho-protons of partially deuterated pyridine used as a substrate and around 700 for H2 and substrate in the active complex with the catalyst.	Hydrogen	219-221	acyl-CoA synthetase long chain family member 1	Homo sapiens	15-19
24040334-13	2013	pluriSelect separation was substantially faster than MACS (1h vs. 2.5h) and no pre-enrichment steps were necessary.	Hydrogen	59-61	myristoylated alanine rich protein kinase C substrate	Homo sapiens	53-57
25251696-5	2014	Molecular docking studies demonstrated quite similar binding patterns of all new pregnenolone derivatives at the active site of CYP17 through hydrogen bonding and hydrophobic interaction.	Hydrogen	142-150	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	128-133
25292410-13	2014	CONCLUSIONS &amp; INFERENCES: These results suggest that exogenous H2 S sulfhydrates KV 4.3 to decrease the membrane potential, thereby enhancing the basal tension of gastric antral smooth muscle.	Hydrogen	67-69	potassium voltage-gated channel subfamily D member 3	Homo sapiens	85-91
25429931-6	2014	For complete basis set (CBS) predictions of hydrogen transfer reaction energies, the OMP2.5 method exhibits a substantially better performance than MP2.5, providing a mean absolute error of 1.1 kcal mol(-1), which is more than 10 times lower than that of MP2.5 (11.8 kcal mol(-1)), and comparing to MP2 (14.6 kcal mol(-1)) there is a more than 12-fold reduction in errors.	Hydrogen	44-52	synaptojanin 2 binding protein	Homo sapiens	85-91
25424294-8	2014	The histochemical study showed lesser expression of COX-2 (p=0.0015) and Bcl-2 (p=0.0012) on HS+PTX group.	Hydrogen	93-95	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	52-57
25172853-7	2014	Indeed, pathway reconstruction using recently published Sakinaw Lake single-cell genomes affiliated with OP9/JS1 and OP8 revealed complete coverage of the Wood-Ljungdahl pathway with potential to drive syntrophic acetate oxidation to hydrogen and carbon dioxide under methanogenic conditions.	Hydrogen	234-242	carboxymethylenebutenolidase homolog	Homo sapiens	109-112
25151121-6	2014	In the early phase of exposure (1h), nicotine mediated intracellular Ca(2+) fluxes and activation of protein kinase C, which in its turn activated NOX1, leading to cellular and mitochondrial oxidative stress.	Hydrogen	32-34	NADPH oxidase 1	Homo sapiens	147-151
25189282-1	2014	A new family of Ir(III) complexes were synthesised and employed as light-induced hydrogen-production photosensitisers in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of &gt;0.2 V between E(PS*/PS(-)) and E(NEt3(+)/NEt3) is required for efficient hydrogen production [i.e., E(PS*/PS(-)) &gt;1.19 V versus NHE].	Hydrogen	81-89	tetraspanin 2	Homo sapiens	232-236
25189282-1	2014	A new family of Ir(III) complexes were synthesised and employed as light-induced hydrogen-production photosensitisers in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of &gt;0.2 V between E(PS*/PS(-)) and E(NEt3(+)/NEt3) is required for efficient hydrogen production [i.e., E(PS*/PS(-)) &gt;1.19 V versus NHE].	Hydrogen	81-89	tetraspanin 2	Homo sapiens	325-329
25189282-1	2014	A new family of Ir(III) complexes were synthesised and employed as light-induced hydrogen-production photosensitisers in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of &gt;0.2 V between E(PS*/PS(-)) and E(NEt3(+)/NEt3) is required for efficient hydrogen production [i.e., E(PS*/PS(-)) &gt;1.19 V versus NHE].	Hydrogen	81-89	tetraspanin 2	Homo sapiens	325-329
25189282-1	2014	A new family of Ir(III) complexes were synthesised and employed as light-induced hydrogen-production photosensitisers in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of &gt;0.2 V between E(PS*/PS(-)) and E(NEt3(+)/NEt3) is required for efficient hydrogen production [i.e., E(PS*/PS(-)) &gt;1.19 V versus NHE].	Hydrogen	81-89	solute carrier family 9 member C1	Homo sapiens	423-426
25189282-1	2014	A new family of Ir(III) complexes were synthesised and employed as light-induced hydrogen-production photosensitisers in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of &gt;0.2 V between E(PS*/PS(-)) and E(NEt3(+)/NEt3) is required for efficient hydrogen production [i.e., E(PS*/PS(-)) &gt;1.19 V versus NHE].	Hydrogen	144-152	tetraspanin 2	Homo sapiens	232-236
25189282-1	2014	A new family of Ir(III) complexes were synthesised and employed as light-induced hydrogen-production photosensitisers in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of &gt;0.2 V between E(PS*/PS(-)) and E(NEt3(+)/NEt3) is required for efficient hydrogen production [i.e., E(PS*/PS(-)) &gt;1.19 V versus NHE].	Hydrogen	144-152	tetraspanin 2	Homo sapiens	325-329
25189282-1	2014	A new family of Ir(III) complexes were synthesised and employed as light-induced hydrogen-production photosensitisers in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of &gt;0.2 V between E(PS*/PS(-)) and E(NEt3(+)/NEt3) is required for efficient hydrogen production [i.e., E(PS*/PS(-)) &gt;1.19 V versus NHE].	Hydrogen	144-152	tetraspanin 2	Homo sapiens	325-329
25189282-1	2014	A new family of Ir(III) complexes were synthesised and employed as light-induced hydrogen-production photosensitisers in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of &gt;0.2 V between E(PS*/PS(-)) and E(NEt3(+)/NEt3) is required for efficient hydrogen production [i.e., E(PS*/PS(-)) &gt;1.19 V versus NHE].	Hydrogen	144-152	solute carrier family 9 member C1	Homo sapiens	423-426
25189282-1	2014	A new family of Ir(III) complexes were synthesised and employed as light-induced hydrogen-production photosensitisers in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of &gt;0.2 V between E(PS*/PS(-)) and E(NEt3(+)/NEt3) is required for efficient hydrogen production [i.e., E(PS*/PS(-)) &gt;1.19 V versus NHE].	Hydrogen	144-152	tetraspanin 2	Homo sapiens	232-236
25189282-1	2014	A new family of Ir(III) complexes were synthesised and employed as light-induced hydrogen-production photosensitisers in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of &gt;0.2 V between E(PS*/PS(-)) and E(NEt3(+)/NEt3) is required for efficient hydrogen production [i.e., E(PS*/PS(-)) &gt;1.19 V versus NHE].	Hydrogen	144-152	tetraspanin 2	Homo sapiens	325-329
25189282-1	2014	A new family of Ir(III) complexes were synthesised and employed as light-induced hydrogen-production photosensitisers in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of &gt;0.2 V between E(PS*/PS(-)) and E(NEt3(+)/NEt3) is required for efficient hydrogen production [i.e., E(PS*/PS(-)) &gt;1.19 V versus NHE].	Hydrogen	144-152	tetraspanin 2	Homo sapiens	325-329
25189282-1	2014	A new family of Ir(III) complexes were synthesised and employed as light-induced hydrogen-production photosensitisers in aqueous systems, where hydrogen evolution was observed only when the PS* was reduced by the sacrificial agent, NEt3, signifying that a minimum potential difference of &gt;0.2 V between E(PS*/PS(-)) and E(NEt3(+)/NEt3) is required for efficient hydrogen production [i.e., E(PS*/PS(-)) &gt;1.19 V versus NHE].	Hydrogen	144-152	solute carrier family 9 member C1	Homo sapiens	423-426
25198547-3	2014	Interestingly, the hydroxyl stretch band in the FTIR spectrum of aqueous NaPF6 solution can be resolved into contributions from three distinct subsets of water: (1) water molecules hydrogen-bonded to other water (i.e. bulk water), (2) water molecules in the hydration shells of Na(+) ions (i.e. cationic hydration shell), and (3) water molecules hydrogen-bonded to PF6(-) ions (i.e. anionic hydration shell).	Hydrogen	346-354	sperm associated antigen 17	Homo sapiens	75-78
25162936-12	2014	The analysis shows that the intermolecular hydrogen bonding between active site residues and the phenolic oxygen of PLP shifts the tautomeric equilibrium toward the N-protonated ketoenamine tautomeric form.	Hydrogen	43-51	pyridoxal phosphatase	Homo sapiens	116-119
25197769-1	2014	Proton conductivity through two-dimensional (2-D) hydrogen-bonding networks within a layered metal-organic framework (MOF) (NH4)2(H2adp)[Zn2(ox)3] 3H2O (H2adp = adipic acid; ox = oxalate) has been successfully controlled by cation substitution.	Hydrogen	50-58	lysine acetyltransferase 8	Homo sapiens	93-122
21587603-2	2010	In the crystal, weak C-H N and C-H O hydrogen bonds link the mol-ecules.	Hydrogen	37-45	chimerin 1	Homo sapiens	21-34
25197769-2	2014	We synthesized a cation-substituted MOF, K2(H2adp)[Zn2(ox)3] 3H2O, where the ammonium ions in a well-defined hydrogen-bonding network are substituted with non-hydrogen-bonding potassium ions, without any apparent change in the crystal structure.	Hydrogen	109-117	lysine acetyltransferase 8	Homo sapiens	36-39
25197769-2	2014	We synthesized a cation-substituted MOF, K2(H2adp)[Zn2(ox)3] 3H2O, where the ammonium ions in a well-defined hydrogen-bonding network are substituted with non-hydrogen-bonding potassium ions, without any apparent change in the crystal structure.	Hydrogen	159-167	lysine acetyltransferase 8	Homo sapiens	36-39
25197769-3	2014	We successfully controlled the proton conductivity by cleavage of the hydrogen bonds in a proton-conducting pathway, showing that the 2-D hydrogen-bonding networks in the MOF truly contribute to the high proton conductivity.	Hydrogen	70-78	lysine acetyltransferase 8	Homo sapiens	171-174
20596565-1	2010	The electrochemical adsorption of underpotential deposited hydrogen (upd-H(ad)) and OH(ad) on structurally well-defined Pt(x)Ru(1-x)/Ru(0001) surface alloys was investigated by cyclic voltammetry and density functional theory (DFT) calculations.	Hydrogen	59-67	uroporphyrinogen decarboxylase	Homo sapiens	69-72
25060863-1	2014	The effects of the planar aromatic organic molecules anthracene and pyrene on the catalytic performance of the intramolecular hydrogen evolving photocatalyst [Ru(tbbpy)2(tpphz)PdCl2](PF6)2 functioning as a photocatalytic dyad have been studied.	Hydrogen	126-134	sperm associated antigen 17	Homo sapiens	183-186
21587572-3	2010	The crystal structure is stabilized through N-H O hydrogen bonds, forming a chain extending along the b axis and through C-H N and C-H Cl inter-actions.	Hydrogen	50-58	chimerin 1	Homo sapiens	121-132
21587549-3	2010	In the crystal, inter-molecular N-H O, C-H N and C-H O hydrogen bonds link the mol-ecules into sheets parallel to the ac plane.	Hydrogen	55-63	chimerin 1	Homo sapiens	39-52
25060863-5	2014	Studies on the photocatalytic hydrogen production show a decreased induction phase and increased turn over frequencies during the initial phase of the catalysis in the presence of anthracene and pyrene utilising the catalyst [Ru(tbbpy)2(tpphz)PdCl2](PF6)2 irrespective of the nature of the polycyclic aromatic hydrocarbon.	Hydrogen	30-38	sperm associated antigen 17	Homo sapiens	250-253
25229150-7	2014	In this study, we have mapped direct interactions between a specific cyclic nucleotide phosphodiesterase (PDE8A) and a PKA regulatory subunit (RIalpha isoform) in mammalian cAMP signaling, by a combination of amide hydrogen/deuterium exchange mass spectrometry, peptide array, and computational docking.	Hydrogen	215-223	phosphodiesterase 8A	Homo sapiens	106-111
20635468-4	2010	The ligand HL3 contains a second phenol group and this is makes an intermolecular hydrogen bond with the phosphine oxide of a neighbouring molecule O2-O3 (under symmetry operation -x, 0.5+y, 0.5-z).	Hydrogen	82-90	dynein cytoplasmic 1 heavy chain 1	Homo sapiens	11-14
25229150-8	2014	The interaction interface of the PDE8A:RIalpha complex, probed by peptide array and hydrogen/deuterium exchange mass spectrometry, brings together regions spanning the phosphodiesterase active site and cAMP-binding sites of RIalpha.	Hydrogen	84-92	phosphodiesterase 8A	Homo sapiens	33-38
20687533-8	2010	Instead, the SA2 assembly immediately disintegrated in hydrogen breaking solvents such dimethylsulfoxide and dimethylformamide, suggesting the involvement of additional intermolecular interactions via hydrogen bonding.	Hydrogen	55-63	stromal antigen 2	Homo sapiens	13-16
25042007-1	2014	The palladium nanoparticle (Pd NP)-decorated LaAlO3 /SrTiO3 (LAO/STO) heterostructure is for the first time used as a hydrogen-gas sensor with very high sensitivity and workability at room temperature.	Hydrogen	118-126	interleukin 4 induced 1	Homo sapiens	61-64
20687533-8	2010	Instead, the SA2 assembly immediately disintegrated in hydrogen breaking solvents such dimethylsulfoxide and dimethylformamide, suggesting the involvement of additional intermolecular interactions via hydrogen bonding.	Hydrogen	201-209	stromal antigen 2	Homo sapiens	13-16
20687533-9	2010	Circular dichroism and Fourier transform infrared spectroscopy excluded well-defined patterns of intramolecular hydrogen bonding and indicated the polyproline type II as the dominant SA2 peptide conformation, which enables intermolecular hydrogen bonding.	Hydrogen	238-246	stromal antigen 2	Homo sapiens	183-186
25042007-1	2014	The palladium nanoparticle (Pd NP)-decorated LaAlO3 /SrTiO3 (LAO/STO) heterostructure is for the first time used as a hydrogen-gas sensor with very high sensitivity and workability at room temperature.	Hydrogen	118-126	nuclear receptor binding SET domain protein 1	Homo sapiens	65-68
20566661-5	2010	Zinc and hydrogen ions regulate Drosophila KCNK0 and mammalian TASK channels, respectively, by interacting with the inactivation gate of these channels.	Hydrogen	9-17	Open rectifier K[+] channel 1	Drosophila melanogaster	43-48
25180755-4	2014	The main objective of this study was to use Hydrogen/deuterium exchange (HDX) to identify how the amide hydrogen bonding network of peptide ligands and the extracellular domain of GLP-1R (nGLP-1R) were altered by binding interactions and to then use this platform to validate direct binding events for putative GLP-1R small molecule ligands.	Hydrogen	44-52	glucagon like peptide 1 receptor	Homo sapiens	180-186
20561551-4	2010	The expression of apelin mRNA was found to be upregulated in the lung tissue in the early several hours after APE induction and decreased at 24 h. The expression of apelin protein in the pulmonary arteries did not change within 24 h after APE, but significantly increased in the bronchial epithelial cells as early as 1h and decreased at 24 h. In normal anesthetized dogs, intravenous bolus administration of apelin significantly reduced the mean arterial pressure (MAP), but did not significantly affect the mean pulmonary arterial pressure (MPAP).	Hydrogen	318-320	apelin	Canis lupus familiaris	18-24
20561551-4	2010	The expression of apelin mRNA was found to be upregulated in the lung tissue in the early several hours after APE induction and decreased at 24 h. The expression of apelin protein in the pulmonary arteries did not change within 24 h after APE, but significantly increased in the bronchial epithelial cells as early as 1h and decreased at 24 h. In normal anesthetized dogs, intravenous bolus administration of apelin significantly reduced the mean arterial pressure (MAP), but did not significantly affect the mean pulmonary arterial pressure (MPAP).	Hydrogen	318-320	apelin	Canis lupus familiaris	165-171
23836469-8	2013	The idea is corroborated by the fact that the most important residues in the hCC sequence are Ser-98 and Tyr-102; these residues are able to form hydrogen bonds via their hydroxyl groups.	Hydrogen	146-154	HCC	Homo sapiens	77-80
20561551-4	2010	The expression of apelin mRNA was found to be upregulated in the lung tissue in the early several hours after APE induction and decreased at 24 h. The expression of apelin protein in the pulmonary arteries did not change within 24 h after APE, but significantly increased in the bronchial epithelial cells as early as 1h and decreased at 24 h. In normal anesthetized dogs, intravenous bolus administration of apelin significantly reduced the mean arterial pressure (MAP), but did not significantly affect the mean pulmonary arterial pressure (MPAP).	Hydrogen	318-320	apelin	Canis lupus familiaris	165-171
23846855-2	2013	Three-dimensional (3D) molecular docking demonstrates the strong hydrogen bonding and hydrophobic interactions of MC with amino acids of aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) within 4 A and subsequent inhibition of cAMP response element-binding protein (CREB), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors.	Hydrogen	65-73	aryl hydrocarbon receptor	Homo sapiens	137-162
25180755-4	2014	The main objective of this study was to use Hydrogen/deuterium exchange (HDX) to identify how the amide hydrogen bonding network of peptide ligands and the extracellular domain of GLP-1R (nGLP-1R) were altered by binding interactions and to then use this platform to validate direct binding events for putative GLP-1R small molecule ligands.	Hydrogen	44-52	glucagon like peptide 1 receptor	Homo sapiens	189-195
23846855-2	2013	Three-dimensional (3D) molecular docking demonstrates the strong hydrogen bonding and hydrophobic interactions of MC with amino acids of aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) within 4 A and subsequent inhibition of cAMP response element-binding protein (CREB), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors.	Hydrogen	65-73	aryl hydrocarbon receptor	Homo sapiens	164-167
21588662-3	2010	However, intra-molecular C-H N and O-H O hydrogen bonds result in six-membered rings and inter-molecular C-H O inter-actions stabilize the crystal structure.	Hydrogen	41-49	chimerin 1	Homo sapiens	25-38
25180755-4	2014	The main objective of this study was to use Hydrogen/deuterium exchange (HDX) to identify how the amide hydrogen bonding network of peptide ligands and the extracellular domain of GLP-1R (nGLP-1R) were altered by binding interactions and to then use this platform to validate direct binding events for putative GLP-1R small molecule ligands.	Hydrogen	104-112	glucagon like peptide 1 receptor	Homo sapiens	180-186
25180755-4	2014	The main objective of this study was to use Hydrogen/deuterium exchange (HDX) to identify how the amide hydrogen bonding network of peptide ligands and the extracellular domain of GLP-1R (nGLP-1R) were altered by binding interactions and to then use this platform to validate direct binding events for putative GLP-1R small molecule ligands.	Hydrogen	104-112	glucagon like peptide 1 receptor	Homo sapiens	189-195
25180755-6	2014	Furthermore, HDX can detect stabilization of exendin-4 and exendin-4[9-39] hydrogen bonding networks at the N-terminal helix [Val19 to Lys27] upon binding to the N-terminal extracellular domain of GLP-1R (nGLP-1R).	Hydrogen	75-83	glucagon like peptide 1 receptor	Homo sapiens	197-203
25180755-7	2014	In addition we show hydrogen bonding network stabilization on nGLP-1R in response to ligand binding, and validate direct binding events with the extracellular domain of the receptor for putative GLP-1R small molecule ligands.	Hydrogen	20-28	glucagon like peptide 1 receptor	Homo sapiens	63-69
25044801-3	2014	Remarkably, as an integrated three-dimensional hydrogen-evolving cathode operating in acidic electrolytes, Cu3 P NW/CF maintains its activity for at least 25 hours and exhibits an onset overpotential of 62 mV, a Tafel slope of 67 mV dec(-1) , and a Faradaic efficiency close to 100 %.	Hydrogen	47-55	deleted in esophageal cancer 1	Homo sapiens	233-239
20662494-5	2010	Electrochemical studies of Pt/Ti(0.7)W(0.3)O(2) show unique CO-tolerant electrocatalytic activity for hydrogen oxidation compared to commercial E-TEK PtRu/C catalysts.	Hydrogen	102-110	TEK receptor tyrosine kinase	Homo sapiens	146-149
23982741-5	2013	Similar to other TRAFs, both intermolecular hydrophobic interaction in super helical "stalk" and hydrogen bonds in "cap" regions contribute directly to the formation of TRAF4 trimer.	Hydrogen	97-105	TNF receptor associated factor 4	Homo sapiens	169-174
24196871-6	2014	Treatment with H2 reduced mRNA levels of osteoclast-specific markers including tartrate resistant acid phosphatase, calcitonin receptor, cathepsin K, metalloproteinase-9, carbonic anhydrase typeII, and vacuolar-type H(+)-ATPase.	Hydrogen	15-17	calcitonin receptor	Mus musculus	116-135
23822586-0	2013	Hydrogen abstraction from n-butyl formate by H  and HO2 .	Hydrogen	0-8	heme oxygenase 2	Homo sapiens	52-55
20542892-8	2010	Both compounds exhibited a strong binding ability to wild-type ERRgamma due to the hydrogen bonding to Glu275 and Arg316.	Hydrogen	83-91	estrogen related receptor gamma	Homo sapiens	63-71
24196871-6	2014	Treatment with H2 reduced mRNA levels of osteoclast-specific markers including tartrate resistant acid phosphatase, calcitonin receptor, cathepsin K, metalloproteinase-9, carbonic anhydrase typeII, and vacuolar-type H(+)-ATPase.	Hydrogen	15-17	cathepsin K	Mus musculus	137-148
24196871-7	2014	Treatment with H2 decreased intracellular reactive oxygen species (ROS) formation, suppressed NADPH oxidase activity, down-regulated Rac1 activity and Nox1 expression, reduced mitochondrial ROS formation, and enhanced nuclear factor E2-related factor 2 nuclear translocation and heme oxygenase-1 activity.	Hydrogen	15-17	Rac family small GTPase 1	Mus musculus	133-137
24196871-7	2014	Treatment with H2 decreased intracellular reactive oxygen species (ROS) formation, suppressed NADPH oxidase activity, down-regulated Rac1 activity and Nox1 expression, reduced mitochondrial ROS formation, and enhanced nuclear factor E2-related factor 2 nuclear translocation and heme oxygenase-1 activity.	Hydrogen	15-17	NADPH oxidase 1	Mus musculus	151-155
24196871-9	2014	Furthermore, treatment with H2 suppressed NF-kappaB activation and reduced phosphorylation of p38, extracellular signal-regulated kinase, c-Jun-N-terminal kinase, and protein kinases B (AKT) stimulated with RANKL.	Hydrogen	28-30	mitogen-activated protein kinase 14	Mus musculus	94-97
23950901-4	2013	SULF1 and SULF2 are highly homologous, extracellular endosulfatases, which post-synthetically edit the sulfation status of HS by removing 6OS from intact chains.	Hydrogen	123-125	sulfatase 2	Mus musculus	10-15
20305288-3	2010	The intestinal infusion of TCA into the CBF rat rapidly (1h) activated the AKT (approximately 9-fold) and ERK1/2 (3- to 5-fold) signaling pathways, downregulated (approximately 50%, 30 min) the mRNA levels of PEPCK and G-6-Pase, and induced (14-fold in 3 h) SHP mRNA.	Hydrogen	57-59	mitogen activated protein kinase 3	Rattus norvegicus	106-112
24949823-0	2014	Enhanced photocatalytic hydrogen production activity via dual modification of MOF and reduced graphene oxide on CdS.	Hydrogen	24-32	lysine acetyltransferase 8	Homo sapiens	78-81
20492513-10	2010	Additionally, hydrogen-rich saline markedly increased the activities of anti-oxidant enzymes superoxide dismutase and catalase and downregulated extracellular signal-regulated protein kinase (ERK)1/2 activation.	Hydrogen	14-22	mitogen activated protein kinase 3	Rattus norvegicus	145-199
20492513-11	2010	CONCLUSIONS: Hydrogen-rich saline attenuates BDL-induced liver damage, possibly by the reduction of inflammation and oxidative stress and the inhibition of the ERK1/2 pathway.	Hydrogen	13-21	mitogen activated protein kinase 3	Rattus norvegicus	160-166
24187844-3	2013	The structure of ACS was confirmed by FT-IR, 1H NMR and element analysis.	Hydrogen	45-47	acyl-CoA synthetase short chain family member 2	Homo sapiens	17-20
24857825-2	2014	Hydrogen abstraction by FeIIIOH- of soybean LOX-1 (sLOX-1) is associated with a large deuterium kinetic isotope effect (D-KIE).	Hydrogen	0-8	oxidized low density lipoprotein receptor 1	Homo sapiens	51-57
23763627-0	2013	AAAA-DDDD quadruple hydrogen-bond arrays featuring NH   N and CH   N hydrogen bonds.	Hydrogen	20-28	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	5-9
23763627-0	2013	AAAA-DDDD quadruple hydrogen-bond arrays featuring NH   N and CH   N hydrogen bonds.	Hydrogen	69-77	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	5-9
23763627-1	2013	The X-ray crystal structure of a previously reported extremely strong quadruple NH   N AAAA-DDDD hydrogen-bond array [5 4] (K(a) = 1.5 x 10(6) M(-1) in CH3CN; K(a) &gt; 3 x 10(12) M(-1) in CH2Cl2) features four short linear hydrogen bonds.	Hydrogen	97-105	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	92-96
23763627-1	2013	The X-ray crystal structure of a previously reported extremely strong quadruple NH   N AAAA-DDDD hydrogen-bond array [5 4] (K(a) = 1.5 x 10(6) M(-1) in CH3CN; K(a) &gt; 3 x 10(12) M(-1) in CH2Cl2) features four short linear hydrogen bonds.	Hydrogen	224-232	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	92-96
23763627-2	2013	Changing the two benzimidazole groups of the DDDD unit to triazole groups replaces two of the NH   N hydrogen bonds with CH   N interactions (complex [5 6]), but only reduces the association constant in CH3CN by 2 orders of magnitude (K(a) = 2.6 x 10(4) M(-1) in CH3CN; K(a) &gt; 1 x 10(7) M(-1) in CH2Cl2).	Hydrogen	101-109	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	45-49
20979846-9	2010	The concentrations of IL-10 in the large V(T) for 2 h group (24 +- 4) ng/L and 4 h group (26 +- 5) ng/L were higher than that in the conventional ventilation group (15 +- 2) ng/L (P all &lt; 0.05), and that in the Large V(T) for 4 h group was higher than that in the 1h group (19 +- 4) ng/L(P &lt; 0.05).	Hydrogen	267-269	interleukin-10	Oryctolagus cuniculus	22-27
20979846-12	2010	(2) The DNA-binding activity of AP-1 in the large V(T) for 2 h group (33.77 +- 8.23) and 4 h group (38 +- 9) were higher than that in the conventional ventilation group (23 +- 9) (P all &lt; 0.01), and that in Large V(T) for 4 h group was higher than that in 1h group (25 +- 9) (P &lt; 0.01).	Hydrogen	259-261	transcription factor Jun	Oryctolagus cuniculus	32-36
20550193-5	2010	Together with the observation of strong peptide-water cross-peaks in (1)H spin diffusion spectra, these results indicate that TAT binding to the membrane-water interface is stabilized not only by electrostatic attraction to the anionic lipids but also by intermolecular hydrogen bonding with the lipid phosphates and water, which may take the role of intramolecular hydrogen bonds in canonical secondary structures.	Hydrogen	270-278	tyrosine aminotransferase	Homo sapiens	126-129
20550193-5	2010	Together with the observation of strong peptide-water cross-peaks in (1)H spin diffusion spectra, these results indicate that TAT binding to the membrane-water interface is stabilized not only by electrostatic attraction to the anionic lipids but also by intermolecular hydrogen bonding with the lipid phosphates and water, which may take the role of intramolecular hydrogen bonds in canonical secondary structures.	Hydrogen	366-374	tyrosine aminotransferase	Homo sapiens	126-129
23763627-3	2013	Related complexes without the triazole groups range in K(a) from 18 to 270 M(-1) in CH3CN, suggesting that the CH   N interactions can be considered part of a strong AAAA-DDDD quadruple hydrogen-bonding array.	Hydrogen	186-194	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	171-175
24857825-7	2014	The kinetic differences between 13R-MnLOX and sLOX-1 may be due to protein dynamics, hydrogen donor-acceptor distances, and to the metal ligands, which may not equalize the 0.7V-gap between the redox potentials of the free metals.	Hydrogen	85-93	oxidized low density lipoprotein receptor 1	Homo sapiens	46-52
24920673-10	2014	LC8 recognizes the signature TQT motif in the first LC8 binding site of Ana2, forming extensive van der Waals contacts and hydrogen bonding with the peptide, whereas the Ana2 site 2 TQC motif forms a uniquely extended beta-strand, not observed in other dynein light chain-target complexes.	Hydrogen	123-131	anastral spindle 2	Drosophila melanogaster	72-76
23956800-4	2013	The CO2 reduction, determined by cyclic voltammetry, occurs at approximately -1150 mV versus the normal hydrogen electrode (NHE).	Hydrogen	104-112	solute carrier family 9 member C1	Homo sapiens	124-127
20541525-4	2010	In pig islets, thapsigargin decreased the insulin secretion by high glucose stimulation in a time-dependent manner (1h, 1.35+/-0.16; 2h, 1.21+/-0.13; 4h, 1.17+/-0.16 vs. 0h, 1.81+/-0.15, n=4, p&lt;0.05, respectively).	Hydrogen	116-118	insulin	Sus scrofa	42-49
24871686-1	2014	Simulations of H2 and CO2 sorption were performed in the metal-organic framework (MOF), [Cu(Me-4py-trz-ia)].	Hydrogen	15-17	lysine acetyltransferase 8	Homo sapiens	57-87
19997046-0	2010	Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release.	Hydrogen	22-30	high mobility group box 1	Mus musculus	100-105
19997046-7	2010	In addition, we found that the beneficial effects of H2 treatment on sepsis and sepsis-associated organ damage were associated with the decreased levels of oxidative product, increased activities of antioxidant enzymes, and reduced levels of high-mobility group box 1 in serum and tissue.	Hydrogen	53-55	high mobility group box 1	Mus musculus	242-267
23567286-3	2013	The inhibition is, at least partially, due to the formation of hydrogen bonds between catalase and flavonoids.	Hydrogen	63-71	catalase	Bos taurus	86-94
24871767-2	2014	The Tafel slope and the exchange current density values associated with hydrogen evolution reaction are determined to be 46 mV dec(-1) and 1.4 x 10(-4) A cm(-2) respectively.	Hydrogen	72-80	deleted in esophageal cancer 1	Homo sapiens	127-133
24830634-0	2014	Ternary Pt/SnO(x)/TiO2 photocatalysts for hydrogen production: consequence of Pt sites for synergy of dual co-catalysts.	Hydrogen	42-50	strawberry notch homolog 1	Homo sapiens	11-14
23602763-11	2013	At 1h post injection, the uptake of (18)F-AlF-NOTA-AE105 in PC-3 tumors was 4.22 +- 0.13%ID/g.	Hydrogen	3-5	afamin	Homo sapiens	42-45
21579414-3	2010	Inter-molecular C-H N and C-H O hydrogen bonds further consolidate the structure into a three-dimensional network.	Hydrogen	32-40	chimerin 1	Homo sapiens	16-29
24873257-0	2014	Synthesis of porous ZnS:Ag2S nanosheets by ion exchange for photocatalytic H2 generation.	Hydrogen	75-77	angiotensin II receptor type 1	Homo sapiens	24-28
21579372-2	2010	The crystal structure is stabilized by inter-molecular N-H S hydrogen bonds, resulting in the formation of eight-membered rings lying about inversion centers and representing R(2) (2)(8) and R(4) (2)(8) motifs.	Hydrogen	61-69	CD1a molecule	Homo sapiens	191-195
20364849-4	2010	Hydrogen adsorption measurements at 740 Torr and 77 K reveal that hydrogen uptakes of 0.68 and 0.83 wt % were observed in 1 and 2, respectively, with BET surface areas of 309 and 328 m(2)/g.	Hydrogen	0-8	delta/notch like EGF repeat containing	Homo sapiens	150-153
20364849-4	2010	Hydrogen adsorption measurements at 740 Torr and 77 K reveal that hydrogen uptakes of 0.68 and 0.83 wt % were observed in 1 and 2, respectively, with BET surface areas of 309 and 328 m(2)/g.	Hydrogen	66-74	delta/notch like EGF repeat containing	Homo sapiens	150-153
20060291-5	2010	During the entire cultivation period (408 h), the highest average hydrogen production rate (HPR(av)) of 11.1 + or - 3.1 ml l(-1) h(-1) was achieved at an irradiance of 320 W m(-2).	Hydrogen	66-74	haptoglobin-related protein	Homo sapiens	92-95
20378345-4	2010	Five other derivatives, that is, 1a, 1g, 1h, 2f, and 2h were slightly less potent than previous compounds but still relatively selective versus TRPV1 and TRPA1.	Hydrogen	41-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	144-149
20378345-4	2010	Five other derivatives, that is, 1a, 1g, 1h, 2f, and 2h were slightly less potent than previous compounds but still relatively selective versus TRPV1 and TRPA1.	Hydrogen	41-43	transient receptor potential cation channel subfamily A member 1	Homo sapiens	154-159
20379517-5	2010	The two hIAPP peptides studied (with and without disulfide bridge) show negative alpha(p), which is close to zero at 250 K and decreases to approximately -1.5 x 10(-3) K(-1) upon heating to 450 K. The analysis of various structural properties of peptides shows a correlation between the intrinsic peptide volumes and the number of intrapeptide hydrogen bonds.	Hydrogen	344-352	islet amyloid polypeptide	Homo sapiens	8-13
20441253-8	2010	The SCP-DFT approach holds promise as an efficient and accurate method for describing large hydrogen-bonded systems, and has the potential to model complex systems with minimal parametrization.	Hydrogen	92-100	urocortin 3	Homo sapiens	4-7
20199107-7	2010	This includes a bidentate hydrogen bonding pattern between PEPA and N754 of the flop isoforms of GluA2 and GluA3 (the corresponding position in the flip isoform is S754).	Hydrogen	26-34	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	97-102
20199107-7	2010	This includes a bidentate hydrogen bonding pattern between PEPA and N754 of the flop isoforms of GluA2 and GluA3 (the corresponding position in the flip isoform is S754).	Hydrogen	26-34	glutamate ionotropic receptor AMPA type subunit 3	Homo sapiens	107-112
20127209-0	2010	Sequence-specific 1H, 13C, and 15N resonance assignments of Diva (Boo), an apoptosis regulator of the Bcl-2 family.	Hydrogen	18-20	Bcl2-like 10	Mus musculus	60-64
20127209-0	2010	Sequence-specific 1H, 13C, and 15N resonance assignments of Diva (Boo), an apoptosis regulator of the Bcl-2 family.	Hydrogen	18-20	Bcl2-like 10	Mus musculus	66-69
19917284-3	2010	Expression and activity profiles of cyp19 and srd5 beta were first established during Silurana (Xenopus) tropicalis embryogenesis from Nieuwkoop-Faber (NF) stage 2 (2-cell stage; 1h post-fertilization) to NF stage 46 (beginning of feeding; 72 h post-fertilization).	Hydrogen	179-181	cytochrome P450 family 19 subfamily A member 1	Xenopus tropicalis	36-41
20496675-6	2010	It revealed that there were no new functional groups in the composite membrane material, and the level of molecular compatibility was achieved, which was based on the existence of inter-molecular hydrogen bond association between PES and micro-nano cellulose.	Hydrogen	196-204	pescadillo ribosomal biogenesis factor 1	Homo sapiens	230-233
20070080-1	2010	Infrared (IR) absorption spectroscopy measurements, performed at 300 K and high pressures (27-55 bar) on several prototypes of metal organic framework (MOF) materials, reveal that the MOF ligands are weakly perturbed upon incorporation of guest molecules and that the molecular hydrogen (H(2)) stretch mode is red-shifted (30-40 cm(-1)) from its unperturbed value (4155 cm(-1) for ortho H(2)).	Hydrogen	278-286	lysine acetyltransferase 8	Homo sapiens	184-187
20078047-6	2010	The resulting supramolecular ABC triblock copolymers were further characterized by a series of methods including 2-D NOESY, isothermal titration calorimetry, and viscometry, proving that the two orthogonal hydrogen-bonding interactions are strong enough to hold the three polymer chains together.	Hydrogen	206-214	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	29-32
19144006-7	2010	Similarly, matured oocytes were found to be enriched with genes involved in cytoskeleton (ACTB), hydrogen ion transporting (ATP6V1C2) and structural constituent of ribosome (RPS27A).	Hydrogen	97-105	ATPase H+ transporting V1 subunit C2	Bos taurus	124-132
19965677-6	2010	Our findings provide direct evidence that the HS chains of syndecan-1 are crucial for the growth and survival of MM cells within the bone marrow environment, and indicate the HS biosynthesis machinery as a potential treatment target in MM.	Hydrogen	46-48	syndecan 1	Homo sapiens	59-69
19965677-6	2010	Our findings provide direct evidence that the HS chains of syndecan-1 are crucial for the growth and survival of MM cells within the bone marrow environment, and indicate the HS biosynthesis machinery as a potential treatment target in MM.	Hydrogen	175-177	syndecan 1	Homo sapiens	59-69
26602503-9	2009	Thermal decomposition of benzyl hydroperoxide, formed by hydrogen abstraction reactions in the benzylperoxy radical and at low temperatures in the benzylperoxy + H and benzyl + HO2 reactions, is also investigated.	Hydrogen	57-65	heme oxygenase 2	Homo sapiens	177-180
19905015-7	2009	The gauche rotamer presents two degenerate conformers, which differ by the position of the SeH (TeH) hydrogen atom above or below the molecular plane.	Hydrogen	101-109	epoxide hydrolase 2	Homo sapiens	91-94
19592162-5	2009	Decreasing the pH lower than the pH(zpc) increased the DCAA adsorption capacities of these adsorbents due to electrostatic interaction and hydrogen bonding caused by protonation of the hydronium ion.	Hydrogen	139-147	zona pellucida glycoprotein 3	Homo sapiens	36-39
21578795-2	2009	Weak C-H N and C-H O hydrogen bonding is present in the crystal structure.	Hydrogen	21-29	chimerin 1	Homo sapiens	5-18
23583298-5	2013	In silico molecular docking analyses showed that parabens fitted well into the active site of ERRgamma, with hydrogen bonds forming between the p-hydroxyl group of parabens and the Glu275/Arg316 of ERRgamma.	Hydrogen	109-117	estrogen related receptor gamma	Homo sapiens	94-102
23583298-5	2013	In silico molecular docking analyses showed that parabens fitted well into the active site of ERRgamma, with hydrogen bonds forming between the p-hydroxyl group of parabens and the Glu275/Arg316 of ERRgamma.	Hydrogen	109-117	estrogen related receptor gamma	Homo sapiens	198-206
24873257-3	2014	With the Ag2S nanocrystals playing the role of hole scavengers, the porous nanosheets exhibit a high photocatalytic H2 generation rate of 104.9 mumol/h/g without using any noble metal cocatalyst.	Hydrogen	116-118	angiotensin II receptor type 1	Homo sapiens	9-13
24710069-7	2014	Modeling suggests that the two hydrogen bonds between the highly conserved residues Ser-528 and glycine-525 are required for PDRP-mediated phosphorylation of the active-site Thr-527 of PPDK.	Hydrogen	31-39	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	185-189
23677982-1	2013	Sodium-hydrogen exchangers (NHE) of the Slc9 gene family are the major regulators of intracellular pH against acidosis in mammalian cells.	Hydrogen	7-15	solute carrier family 9 member C1	Homo sapiens	28-31
24737316-6	2014	All compounds bind to the active site of beta-Gal with the sugar-mimicking moiety making hydrogen bonds to active site residues.	Hydrogen	89-97	galactosidase beta 1	Homo sapiens	41-49
24046613-4	2013	Mol-ecules in the crystal are linked into a three-dimensional network by C-H S and C-H O hydrogen bonds.	Hydrogen	89-97	lysosomal trafficking regulator	Homo sapiens	73-86
24721313-4	2014	More significantly, compound 1h showed greater than 4 folds selectivity over highly homologous TCPTP.	Hydrogen	29-31	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	95-100
23592585-0	2013	How is a metabolic intermediate formed in the mechanism-based inactivation of cytochrome P450 by using 1,1-dimethylhydrazine: hydrogen abstraction or nitrogen oxidation?	Hydrogen	126-134	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	89-93
24643582-0	2014	Heterostructured ZnO/SnO(2-x) nanoparticles for efficient photocatalytic hydrogen production.	Hydrogen	73-81	strawberry notch homolog 1	Homo sapiens	21-24
23576395-0	2013	Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry.	Hydrogen	13-21	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	39-44
24826173-3	2014	These chains help form parallel chains of cations through N-H O, C-H N and C-H Br hydrogen bonds.	Hydrogen	82-90	chimerin 1	Homo sapiens	65-78
23357360-9	2013	Similar results were obtained in hot-plate test, PC/beta-CD, in all doses, significantly reduces (p&lt;0.01 or p&lt;0.001) nociceptive behavior for 8h while isolated PC for 1h, did so only in higher dose.	Hydrogen	173-175	beta-carotene oxygenase 1	Mus musculus	52-59
24782664-6	2014	PID controller is presented to control flow of hydrogen and oxygen to FC and improve transient and steady state responses of the output voltage to load disturbances.	Hydrogen	47-55	metastasis associated 1 family member 2	Homo sapiens	0-3
26417228-6	2013	In this context, two novel compounds (ChemBank ID 2110359 and 3075417) were found to be more potent inhibitors of neuraminidase than control drugs as zanamivir and oseltamivir in terms of their robust binding energies, strong inhibition constant (Ki) and better hydrogen bond interactions between the protein-ligand complex.	Hydrogen	262-270	neuraminidase 1	Homo sapiens	114-127
24748754-10	2014	Kaempferol-3-O-b-D-glucopyranoside, a Secondary metabolite of S.interrupta form 6 hydrogen bond interactions with Arg 202, Gln 207, Gly 227, Gly 229, Thr 231 and Ala 232 human DEAD box RNA helicase, DDX3 protein and is equivalent to crystal structure of adenosine mono phosphate to DDX3.	Hydrogen	82-90	DEAD-box helicase 3 X-linked	Homo sapiens	199-203
23537018-6	2013	In the standard comet assay, GSE significantly diminished hydrogen-peroxide-induced DNA damage in a dose-dependent manner.	Hydrogen	58-66	CELIAC2	Homo sapiens	29-32
24748754-10	2014	Kaempferol-3-O-b-D-glucopyranoside, a Secondary metabolite of S.interrupta form 6 hydrogen bond interactions with Arg 202, Gln 207, Gly 227, Gly 229, Thr 231 and Ala 232 human DEAD box RNA helicase, DDX3 protein and is equivalent to crystal structure of adenosine mono phosphate to DDX3.	Hydrogen	82-90	DEAD-box helicase 3 X-linked	Homo sapiens	282-286
23095256-3	2013	With this aim, a 3D pharmacophore model was created based on known ABCB1 inhibitors with correlation coefficient of 0.94, comprising three hydrophobic features and one hydrogen bond acceptor.	Hydrogen	168-176	ATP binding cassette subfamily B member 1	Canis lupus familiaris	67-72
24603692-8	2014	Molecular docking studies confirmed that the higher renin-inhibitory activity of RALP may be due to formation of several hydrogen bonds (H-bonds) with the enzyme"s active site residues.	Hydrogen	121-129	renin	Rattus norvegicus	52-57
24345161-0	2014	H2 S modulates duodenal motility in male rats via activating TRPV1 and K(ATP) channels.	Hydrogen	0-2	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	61-66
23262274-6	2013	In primary embryonic cerebellar neuron cultures treated under hypoxia (0.5% O(2)) and low glucose (1g/L) conditions (HLG) for 1h, GH levels increased 1.16-fold compared to the control.	Hydrogen	126-128	growth hormone	Gallus gallus	130-132
23340693-9	2013	These results showed that hydrogen-rich saline was able to attenuate             FBS-induced VSMC proliferation and neointimal hyperplasia by inhibiting ROS production             and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways.	Hydrogen	26-34	mitogen activated protein kinase 3	Rattus norvegicus	205-211
23340693-9	2013	These results showed that hydrogen-rich saline was able to attenuate             FBS-induced VSMC proliferation and neointimal hyperplasia by inhibiting ROS production             and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways.	Hydrogen	26-34	mitogen activated protein kinase kinase 1	Rattus norvegicus	212-218
24096061-2	2014	Cd-MOF is a 2D infinite layer framework, which is further interconnected by hydrogen-bond interactions leading to a 3D supramolecular architecture.	Hydrogen	76-84	lysine acetyltransferase 8	Homo sapiens	3-6
23229515-4	2013	We demonstrate that CLOCK and BMAL1 bHLH domains can be mutually selected, and that hydrogen-bonding networks mediate their E-box recognition.	Hydrogen	84-92	clock circadian regulator	Homo sapiens	20-25
24225950-8	2014	Remarkably, Pep2-8 mimicked secondary structural elements of the EGF(A) domain that interact with PCSK9, notably the beta-strand and a discontinuous short alpha-helix, and it engaged in the same beta-sheet hydrogen bonds as EGF(A) does.	Hydrogen	206-214	VPS11 core subunit of CORVET and HOPS complexes	Homo sapiens	12-18
24211359-5	2014	The structures determined for the epsilon- and eta-forms supported the presence of hydrogen bonds between the ST molecules, as the IR and solid-state NMR spectra indicated.	Hydrogen	83-91	endothelin receptor type A	Homo sapiens	47-50
24299040-4	2013	Ultrathin MoS2 nanoplates exhibit an excellent activity for hydrogen evolution reaction (HER) with a small onset potential of 0.09 V, a low Tafel slope of 53 mV dec(-1), and remarkable stability.	Hydrogen	60-68	deleted in esophageal cancer 1	Homo sapiens	161-167
19806008-3	2009	Interestingly, KLHL1 upregulates high and low voltage-gated calcium currents (Ca(V)2.1 and Ca(V)3.2) and interacts with their respective principal subunits, alpha(1A) and alpha(1H).	Hydrogen	177-179	kelch-like 1	Mus musculus	15-20
19806008-7	2009	In contrast, actin-F stabilization on its own increased basal alpha(1H) activity similar to KLHL1 but without synergy in its presence, suggesting KLHL1 requires actin-polymerization to increase alpha(1H) currents.	Hydrogen	200-202	kelch-like 1	Mus musculus	146-151
19806008-9	2009	Interestingly, pharmacological or genetic disruption of endosomal recycling eliminated the increase in channel number by KLHL1 demonstrating this effect occurs via enhanced alpha(1H) re-insertion through the recycling endosome.	Hydrogen	179-181	kelch-like 1	Mus musculus	121-126
24320225-2	2013	For example, X-ray diffraction studies demonstrate that [kappa(4)-Tptm]ZnF forms an adduct with water in which hydrogen bonding between the fluoride ligands and water molecules serves to link pairs of [kappa(4)-Tptm]ZnF molecules with a [F   (H-O-H)2   F] motif.	Hydrogen	111-119	zinc finger protein 763	Homo sapiens	71-74
19767119-5	2009	IL-1beta treatment for 1h activated JNK and resulted in both post-translational modification and reduction of nuclear RXRalpha.	Hydrogen	23-25	retinoid X receptor alpha	Mus musculus	118-126
24320225-2	2013	For example, X-ray diffraction studies demonstrate that [kappa(4)-Tptm]ZnF forms an adduct with water in which hydrogen bonding between the fluoride ligands and water molecules serves to link pairs of [kappa(4)-Tptm]ZnF molecules with a [F   (H-O-H)2   F] motif.	Hydrogen	111-119	zinc finger protein 763	Homo sapiens	216-219
24141568-11	2013	In molecular docking study, JG6 appeared to interact with CXCL12 via multiple polar interactions, including 6 ionic bonds and 7 hydrogen bonds.	Hydrogen	128-136	C-X-C motif chemokine ligand 12	Homo sapiens	58-64
19446049-7	2009	Short-term treatment of HUVECs with Ti for 1h effectively enhanced the phosphorylation of eNOS, PKC (pan) and ERK1/2.	Hydrogen	43-45	mitogen activated protein kinase 3	Rattus norvegicus	110-116
23886864-3	2013	By exposure to stress (1h/day), the heartbeat and cardiac output in vitamin C-insufficient Gulo(-/-) mice were definitely decreased, despite a significant increase of adrenaline (ADR) and noradrenaline (NA) production.	Hydrogen	23-25	gulonolactone (L-) oxidase	Mus musculus	91-95
19817549-3	2009	This technology uses the helicase"s capability to disrupt the hydrogen bonds of a Watson-Crick base pair in order to separate dsDNA.	Hydrogen	62-70	helicase for meiosis 1	Homo sapiens	25-33
24152306-0	2013	Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry.	Hydrogen	95-103	coagulation factor VIII	Homo sapiens	68-91
19583443-4	2009	In this study, a QSAR model and pharmacophore map of neuraminidase (NA) type 1 (N1) contained two hydrogen bond acceptor features, one hydrogen bond donor feature, and one positive ionizable feature.	Hydrogen	98-106	neuraminidase 1	Homo sapiens	53-66
19583443-4	2009	In this study, a QSAR model and pharmacophore map of neuraminidase (NA) type 1 (N1) contained two hydrogen bond acceptor features, one hydrogen bond donor feature, and one positive ionizable feature.	Hydrogen	135-143	neuraminidase 1	Homo sapiens	53-66
24152306-5	2013	OBJECTIVES: To map the epitopes of anti-FVIII mAbs, three of which are classic inhibitors and one of which is a non-classic inhibitor, by the use of hydrogen-deuterium exchange coupled with mass spectrometry (HDX-MS).	Hydrogen	149-157	coagulation factor VIII	Homo sapiens	40-45
20024801-6	2009	The two domains of the protein are bound by a set of approximately 12 hydrogen bonds, specific to the particular POP protein.	Hydrogen	70-78	prolyl endopeptidase	Homo sapiens	113-116
23848935-6	2013	For Br2 elimination, a pathway from the isomer on the singlet PES is found which involves a simultaneous Br2 loss with 1,2-hydrogen shift; this pathway lies lower in energy than a concerted three-center elimination from the parent 1,1-EDB.	Hydrogen	123-131	vesicle associated membrane protein 8	Homo sapiens	235-238
19545622-9	2009	These results demonstrate that CaMKII plays a critical upstream role in mediating the effects of H(2)O(2) on ERK1/2, PKB, and IGF-1R phosphorylation.	Hydrogen	97-101	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	31-37
19672534-1	2009	Hydrogen and dihydrogen bonding of the fluorinated alcohol (CF(3))(2)CHOH with the transition metal complex WH(CO)(2)(NO)(PMe(3))(2) has been explored by a set of four exemplary density functional theory methods that comprises the BP86, PBE, B3LYP and TPSS functionals.	Hydrogen	13-23	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	237-240
19655724-4	2009	We estimate the dispersion, polar, and hydrogen bonding Hansen parameter for the nanotubes to be &lt;delta(D)&gt; = 17.8 MPa(1/2), &lt;delta(P)&gt; = 7.5 MPa(1/2), and &lt;delta(H)&gt; = 7.6 MPa(1/2).	Hydrogen	39-47	guanylate binding protein 4	Homo sapiens	121-128
19606845-0	2009	A large-surface-area boracite-network-topology porous MOF constructed from a conjugated ligand exhibiting a high hydrogen uptake capacity.	Hydrogen	113-121	lysine acetyltransferase 8	Homo sapiens	54-57
20055160-6	2009	The degree of interaction between vancomycin and ofloxacin is determined as follows: hydrogen bond occurring with carboxylic group at C-6 of ofloxacin and hydroxyl group of sugar part of vancomycin, the matching degree of molecular sizes of ofloxacin with the pocket in domain I of vancomycin and the hydrophobic interaction between methyl group at C-10 of piperidine group of ofloxacin and N-methyl leucine of vancomycin.	Hydrogen	85-93	complement C6	Homo sapiens	134-137
19515843-8	2009	The C3-ketone of finasteride accepts hydrogen bonds from the catalytic residues Tyr-58 and Glu-120 in the active site of AKR1D1, providing an explanation for the competitive inhibition observed.	Hydrogen	37-45	aldo-keto reductase family 1 member D1	Homo sapiens	121-127
19530697-4	2009	In addition, relative to the conventional carboxamide carbonyl, serving as a key hydrogen-bond acceptor during ligand-CB1 receptor interaction, the corresponding polarizable thione carbonyl might play a more critical role in stabilizing the Asp366-Lys192 salt bridge in the proposed CB1-receptor homology model and inducing significant selectivity for CB1R over CB2R.	Hydrogen	81-89	cannabinoid receptor 1 (brain)	Mus musculus	118-121
19184379-4	2009	A hook type profile of rotational reorientation time (tau(r)) vs viscosity (eta) is obtained for all the solutes in dipolar aprotic mixture of dimethyl sulphoxide-water, with the rotational reorientation times being longer in organic solvent-rich zone, compared to the corresponding isoviscous point in water-rich zone due to strong hydrogen bonding.	Hydrogen	333-341	endothelin receptor type A	Homo sapiens	76-79
19636953-0	2009	1H, 13C, 15N backbone and side-chain resonance assignments of the Bright/ARID domain from the human histone demethylase JARID1B.	Hydrogen	0-2	lysine demethylase 5B	Homo sapiens	120-127
19636955-0	2009	Backbone and side-chain 1H, 13C, 15N resonance assignments of rat lipocalin2.	Hydrogen	24-26	lipocalin 2	Rattus norvegicus	66-76
23414864-11	2013	RESULTS: After 1h exposure, E12 cultures adhered or internalised more NEC-derived bacteria than standard strain E. coli and more suspended in FF than BM (P&lt;0.001).	Hydrogen	15-17	epididymal sperm binding protein 1	Homo sapiens	28-31
23318673-7	2013	Exposure of neurons to LTD4 for 1h showed activation of NF-kappaB pathway, by assessing the levels of p65 or phospho-p65 in the nucleus, and either CysLT(1)R antagonist pranlukast or NF-kappaB inhibitor PDTC prevented the nuclear translocation of p65 and the consequent phosphorylation.	Hydrogen	32-34	RELA proto-oncogene, NF-kB subunit	Homo sapiens	102-105
23318673-7	2013	Exposure of neurons to LTD4 for 1h showed activation of NF-kappaB pathway, by assessing the levels of p65 or phospho-p65 in the nucleus, and either CysLT(1)R antagonist pranlukast or NF-kappaB inhibitor PDTC prevented the nuclear translocation of p65 and the consequent phosphorylation.	Hydrogen	32-34	RELA proto-oncogene, NF-kB subunit	Homo sapiens	117-120
23318673-7	2013	Exposure of neurons to LTD4 for 1h showed activation of NF-kappaB pathway, by assessing the levels of p65 or phospho-p65 in the nucleus, and either CysLT(1)R antagonist pranlukast or NF-kappaB inhibitor PDTC prevented the nuclear translocation of p65 and the consequent phosphorylation.	Hydrogen	32-34	RELA proto-oncogene, NF-kB subunit	Homo sapiens	117-120
23223579-0	2013	Critical hydrogen bond formation for activation of the angiotensin II type 1 receptor.	Hydrogen	9-17	angiotensin II receptor type 1	Homo sapiens	55-85
23326519-6	2013	Further investigations through the residue/base motion correlation and DNA dynamics analyses predicted that the binding of Smad4 protein to DNA molecule in the heteromeric Smad4+DNA+Smad1/3 model induces an allosteric communication from the Smad4-DNA interface to Smad1/Smad3-DNA interface via DNA base-pair helical motions, surface conformation changes and new hydrogen bond formations.	Hydrogen	362-370	SMAD family member 4	Homo sapiens	123-128
23326519-6	2013	Further investigations through the residue/base motion correlation and DNA dynamics analyses predicted that the binding of Smad4 protein to DNA molecule in the heteromeric Smad4+DNA+Smad1/3 model induces an allosteric communication from the Smad4-DNA interface to Smad1/Smad3-DNA interface via DNA base-pair helical motions, surface conformation changes and new hydrogen bond formations.	Hydrogen	362-370	SMAD family member 4	Homo sapiens	172-177
23326519-6	2013	Further investigations through the residue/base motion correlation and DNA dynamics analyses predicted that the binding of Smad4 protein to DNA molecule in the heteromeric Smad4+DNA+Smad1/3 model induces an allosteric communication from the Smad4-DNA interface to Smad1/Smad3-DNA interface via DNA base-pair helical motions, surface conformation changes and new hydrogen bond formations.	Hydrogen	362-370	SMAD family member 1	Homo sapiens	182-189
23326519-6	2013	Further investigations through the residue/base motion correlation and DNA dynamics analyses predicted that the binding of Smad4 protein to DNA molecule in the heteromeric Smad4+DNA+Smad1/3 model induces an allosteric communication from the Smad4-DNA interface to Smad1/Smad3-DNA interface via DNA base-pair helical motions, surface conformation changes and new hydrogen bond formations.	Hydrogen	362-370	SMAD family member 4	Homo sapiens	172-177
23326519-6	2013	Further investigations through the residue/base motion correlation and DNA dynamics analyses predicted that the binding of Smad4 protein to DNA molecule in the heteromeric Smad4+DNA+Smad1/3 model induces an allosteric communication from the Smad4-DNA interface to Smad1/Smad3-DNA interface via DNA base-pair helical motions, surface conformation changes and new hydrogen bond formations.	Hydrogen	362-370	SMAD family member 1	Homo sapiens	182-187
23326519-6	2013	Further investigations through the residue/base motion correlation and DNA dynamics analyses predicted that the binding of Smad4 protein to DNA molecule in the heteromeric Smad4+DNA+Smad1/3 model induces an allosteric communication from the Smad4-DNA interface to Smad1/Smad3-DNA interface via DNA base-pair helical motions, surface conformation changes and new hydrogen bond formations.	Hydrogen	362-370	SMAD family member 3	Homo sapiens	270-275
23326534-4	2013	The results show that H(2) promoted 2-[(14)C]-deoxy-d-glucose (2-DG) uptake into C2C12 cells via the translocation of glucose transporter Glut4 through activation of phosphatidylinositol-3-OH kinase (PI3K), protein kinase C (PKC), and AMP-activated protein kinase (AMPK), although it did not stimulate the translocation of Glut2 in Hep G2 cells.	Hydrogen	22-26	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	323-328
23148501-5	2012	2D 1H-1H NMR TOCSY provided evidence of covalent binding of the europium analog of the C-6 compound to HSA-Cys34.	Hydrogen	3-5	complement C6	Homo sapiens	87-90
23148501-5	2012	2D 1H-1H NMR TOCSY provided evidence of covalent binding of the europium analog of the C-6 compound to HSA-Cys34.	Hydrogen	6-8	complement C6	Homo sapiens	87-90
23129151-1	2012	Active in alkaline environment: The activity of nickel, silver, and copper catalysts for the electrochemical transformation of water to molecular hydrogen in alkaline solutions was enhanced by modification of the metal surfaces by Ni(OH)(2) (see picture; I = current density and eta = overpotential).	Hydrogen	146-154	endothelin receptor type A	Homo sapiens	214-217
24072185-1	2013	Using a density functional theory calculation including van der Waals (vdW) corrections, we report that H2 adsorption in a cubic-crystalline microporous metal-organic framework (MOF-5) leads to volume shrinkage, which is in contrast to the intuition that gas adsorption in a confined system (e.g., pores in a material) increases the internal pressure and then leads to volumetric expansion.	Hydrogen	104-106	lysine acetyltransferase 8	Homo sapiens	178-181
22579959-0	2012	Direct interaction of ONO-5046 with human neutrophil elastase through 1H NMR and molecular docking.	Hydrogen	70-72	elastase, neutrophil expressed	Homo sapiens	42-61
24072185-2	2013	This extraordinary phenomenon is closely related to the vdW interactions between MOF and H2 along with the H2-H2 interaction, rather than the Madelung-type electrostatic interaction.	Hydrogen	89-91	lysine acetyltransferase 8	Homo sapiens	81-84
24072185-2	2013	This extraordinary phenomenon is closely related to the vdW interactions between MOF and H2 along with the H2-H2 interaction, rather than the Madelung-type electrostatic interaction.	Hydrogen	107-109	lysine acetyltransferase 8	Homo sapiens	81-84
24072185-3	2013	At low temperatures, H2 molecules adsorbed in the MOF-5 form highly symmetrical interlinked nanocages that change from a cube-like shape to a sphere-like shape with H2 loading, helping to exert centrosymmetric forces and hydrostatic (volumetric) stresses from the collection of dispersive interactions.	Hydrogen	21-23	lysine acetyltransferase 8	Homo sapiens	50-53
24072185-3	2013	At low temperatures, H2 molecules adsorbed in the MOF-5 form highly symmetrical interlinked nanocages that change from a cube-like shape to a sphere-like shape with H2 loading, helping to exert centrosymmetric forces and hydrostatic (volumetric) stresses from the collection of dispersive interactions.	Hydrogen	165-167	lysine acetyltransferase 8	Homo sapiens	50-53
24093586-4	2013	The insensitivity of the studied compounds to other anions (Cl, Br, HSO4, PF6) is consequence of the instability of the corresponding hydrogen-bonded complexes.	Hydrogen	134-142	sperm associated antigen 17	Homo sapiens	74-77
22883448-2	2012	The use of (2)H MAS allows one to measure the chemical shift, delta, quadrupolar coupling constant, C(Q), and asymmetry in the quadrupolar interaction, eta(Q), for each type of hydrogen bond present in the system.	Hydrogen	177-185	endothelin receptor type A	Homo sapiens	152-155
22967955-12	2012	CONCLUSIONS: We confirm a t-Pa effect using this stroke model in the C57BL76 mouse strain and demonstrate a chronological sequence MRI imaging after t-PA using a 1H surface cryo coil in a 9.4 T MRI.	Hydrogen	162-164	plasminogen activator, tissue	Mus musculus	149-153
23864610-6	2013	The data indicate that HS(-) is a very good substrate for AE1; the Cl(-)/HS(-) exchange rate is about one-third as rapid as Cl(-)/HCO3(-) exchange.	Hydrogen	23-25	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	58-61
24085537-5	2013	The substituted groups on the pyrrolidine ring of Lig1 also show a strong tendency to mediate protein-ligand interactions through the hydrogen bonds formed between the amino or amide groups of Lig1 and the carboxyl O atoms of Glu234, Glu278, and Asp292 of PKBalpha.	Hydrogen	134-142	DNA ligase 1	Homo sapiens	50-54
26605715-3	2012	We find that in the first epitaxial water adlayer, water molecules that form strong hydrogen bonds with the oxygen on the mica surface show little motions, thereby solid-like, while those "bridging" water molecules on top of the first water adlayer exhibit "itinerant" behavior, thereby liquid-like.	Hydrogen	84-92	MHC class I polypeptide-related sequence A	Homo sapiens	122-126
24085537-5	2013	The substituted groups on the pyrrolidine ring of Lig1 also show a strong tendency to mediate protein-ligand interactions through the hydrogen bonds formed between the amino or amide groups of Lig1 and the carboxyl O atoms of Glu234, Glu278, and Asp292 of PKBalpha.	Hydrogen	134-142	DNA ligase 1	Homo sapiens	193-197
24050618-11	2013	The hydrogen abstraction of HO2( ) from the F-adduct radical affords fluorobenzene and H2O2 as the final products.	Hydrogen	4-12	heme oxygenase 2	Homo sapiens	28-31
23037534-1	2012	Hydrogen generation through direct photoelectrolysis of water was studied using photoelectrochemical (PEC) cells made of Mn-doped GaN photoelectrodes.	Hydrogen	0-8	gigaxonin	Homo sapiens	130-133
22618865-0	2013	1H, 13C and 15N resonance assignments of the pyrin domain from human PYNOD.	Hydrogen	0-2	MEFV innate immuity regulator, pyrin	Homo sapiens	45-50
22776858-5	2012	The porous structure with increased BET surface area and pore volume shows a much higher hydrogen production rate under simulated sunlight irradiation than thiourea-derived and dicyanamide-derived g-C3N4.	Hydrogen	89-97	delta/notch like EGF repeat containing	Homo sapiens	36-39
22752790-0	2013	1H, 13C and 15N assignment of D2 domain of human fibroblast growth factor receptor 4.	Hydrogen	0-2	fibroblast growth factor receptor 4	Homo sapiens	49-84
24106224-3	2013	The optimized Cu(2+)-surface-modified Znx Cd1-x S photocatalyst has a high H2-production rate of 4638.5 mumolh(-1) g(-1) and an apparent quantum efficiency of 20.9% at 420 nm, exceeding that of Cu(2+)-bulk-modified catalyst at the same copper content.	Hydrogen	75-77	CD1c molecule	Homo sapiens	42-45
22822061-8	2012	Prediction of whole hTLR9 ECD-CpG ODN interactions revealed that Arg-337 and Lys-338 directly contact CpG ODN through hydrogen bonding, whereas Lys-347, Arg-348, and His-353 contribute to stabilizing the shape of the ligand binding region.	Hydrogen	118-126	toll like receptor 9	Homo sapiens	20-25
23940029-0	2013	Dynamics of cleft closure of the GluA2 ligand-binding domain in the presence of full and partial agonists revealed by hydrogen-deuterium exchange.	Hydrogen	118-126	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	33-38
22530954-5	2012	We then show that the non-conserved K347 (6.58) appears to facilitate in guiding Esmolol to the extracellular surface via hydrogen bonds in the beta(1) adrenoceptor.	Hydrogen	122-130	adrenoceptor beta 1	Homo sapiens	144-164
23940029-6	2013	Here, we used NMR measurements of hydrogen-deuterium exchange to determine the stability of hydrogen bonds in the GluA2 (AMPA receptor) ligand-binding domain in the presence of several full and partial agonists.	Hydrogen	34-42	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	114-119
23940029-6	2013	Here, we used NMR measurements of hydrogen-deuterium exchange to determine the stability of hydrogen bonds in the GluA2 (AMPA receptor) ligand-binding domain in the presence of several full and partial agonists.	Hydrogen	92-100	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	114-119
22931625-0	2012	[Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide- induced acute lung injury].	Hydrogen	11-19	mitogen activated protein kinase 14	Rattus norvegicus	34-37
23934108-5	2013	Structural and functional analysis illustrates that MEK inhibitors with superior efficacy in KRAS-driven tumours (GDC-0623 and G-573, the former currently in phase I clinical trials) form a strong hydrogen-bond interaction with S212 in MEK that is critical for blocking MEK feedback phosphorylation by wild-type RAF.	Hydrogen	197-205	zinc fingers and homeoboxes 2	Homo sapiens	312-315
22931625-7	2012	RESULTS: Hydrogen inhalation decreased the expression of p-p38 MAPK in the lung tissue, and significantly reduced TNF-alpha content in the lung tissue and serum of rats with ALI.	Hydrogen	9-17	mitogen activated protein kinase 14	Rattus norvegicus	59-62
22931625-8	2012	CONCLUSION: Hydrogen inhalation can decrease the expression of TNF-alpha in the lung tissue and serum, and this effect may be related with reduced p38 MAPK expression and inhibition of p38 MAPK activation.	Hydrogen	12-20	mitogen activated protein kinase 14	Rattus norvegicus	147-150
22931625-8	2012	CONCLUSION: Hydrogen inhalation can decrease the expression of TNF-alpha in the lung tissue and serum, and this effect may be related with reduced p38 MAPK expression and inhibition of p38 MAPK activation.	Hydrogen	12-20	mitogen activated protein kinase 14	Rattus norvegicus	185-188
24044061-2	2013	METHODS: Lactase persistence phenotype was tested by hydrogen breath test in 52 Omani Adults using the Micro H2 analyzer.	Hydrogen	53-61	lactase	Homo sapiens	9-16
23853097-5	2013	Here, we report the 2.8 A crystal structure of 6C2 Fab in complex with the A-chain of ricin (RTA), which reveals an extensive antigen-antibody interface that contains both hydrogen bonds and van der Waals contacts.	Hydrogen	172-180	RNA binding fox-1 homolog 2	Homo sapiens	93-96
22830687-7	2012	Test calculations by MP2 and DFT functionals with homogeneous and heterogeneous solvation, involving hydrogen bonding, vdW interaction, metal-ligand binding, cation-pi, and ionic interaction, show the robustness and adaptability of the EDA-PCM method.	Hydrogen	101-109	ectodysplasin A	Homo sapiens	236-239
23977131-8	2013	Homology modeling based on the structure of a bacterial Kir channel protein suggested that the effect of R162W mutation is a result of loss of hydrogen bonding by the regulatory lipid binding domain of the cytoplasmic structure.	Hydrogen	143-151	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	56-59
22525098-4	2012	Because previous studies of the related enzyme from bovine liver had suggested loss of the C-5 hydrogen from UDP-gluco-hexodialdose due to keto-enol tautomerism, we examined incorporation of solvent deuterium into product(s) of UDP-glucose oxidation by hUGDH.	Hydrogen	95-103	complement C5	Bos taurus	91-94
19264848-9	2009	Our results strongly suggest that antidepressants interact with Kir4.1 channel pore residues by hydrogen bond and ionic interactions, which account for their preferential inhibitory action on Kir4.1 current.	Hydrogen	96-104	potassium inwardly rectifying channel subfamily J member 10 L homeolog	Xenopus laevis	64-70
19264848-9	2009	Our results strongly suggest that antidepressants interact with Kir4.1 channel pore residues by hydrogen bond and ionic interactions, which account for their preferential inhibitory action on Kir4.1 current.	Hydrogen	96-104	potassium inwardly rectifying channel subfamily J member 10 L homeolog	Xenopus laevis	192-198
23727062-8	2013	Our results showed that the expression of Cdh1 was decreased while Skp2 (the downstream substrate of APC-Cdh1) was increased in astrocytes after 1h oxygen-glucose deprivation and reperfusion.	Hydrogen	145-147	S-phase kinase associated protein 2	Homo sapiens	67-71
22699229-9	2012	The results of this investigation indicated that the enhancement of selectivity of Sil-poly(ODA-alt-DGMI) towards the test analytes arose from the multiple interaction mechanism such as hydrophobic effect, carbonyl-pi and hydrogen-bonding interactions, and such integrated interactions originated from the addition of two amide groups in the N-substituted maleimide monomer.	Hydrogen	222-230	STIL centriolar assembly protein	Homo sapiens	83-86
23631473-4	2013	The catalytic rate observed in dry acetonitrile for the oxidation of H2 depends on base size, with larger bases (NEt3, t-BuNH2) resulting in much slower catalysis than n-BuNH2.	Hydrogen	69-71	tetraspanin 2	Homo sapiens	113-117
22658537-2	2012	Hydroxycinnamic acid or analogs of natural products are important for potent inhibitory and selectivity against MMPs, and the solvent effect in the S1" pocket can affect the hydrophobic interactions and hydrogen bonds between MMPIs and MMPS, making MMPIs exhibit certain selectivity for a specific MMP isoenzyme.	Hydrogen	203-211	matrix metallopeptidase 2	Homo sapiens	112-116
22658537-2	2012	Hydroxycinnamic acid or analogs of natural products are important for potent inhibitory and selectivity against MMPs, and the solvent effect in the S1" pocket can affect the hydrophobic interactions and hydrogen bonds between MMPIs and MMPS, making MMPIs exhibit certain selectivity for a specific MMP isoenzyme.	Hydrogen	203-211	matrix metallopeptidase 2	Homo sapiens	236-240
22658537-2	2012	Hydroxycinnamic acid or analogs of natural products are important for potent inhibitory and selectivity against MMPs, and the solvent effect in the S1" pocket can affect the hydrophobic interactions and hydrogen bonds between MMPIs and MMPS, making MMPIs exhibit certain selectivity for a specific MMP isoenzyme.	Hydrogen	203-211	matrix metallopeptidase 2	Homo sapiens	112-115
19450486-3	2009	The models differed in the protonation site of His(260) in the chromophore-binding pocket such that either the delta-nitrogen (M-HSD) or the epsilon-nitrogen (M-HSE) carried a hydrogen.	Hydrogen	176-184	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	161-164
19317426-0	2009	Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry.	Hydrogen	74-82	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	38-58
19317426-3	2009	We utilized hydrogen-deuterium (H-D) exchange mass spectrometry for investigating CYP46A1-ligand interactions.	Hydrogen	12-20	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	82-89
23631473-5	2013	The addition of water accelerates the rate of catalysis by facilitating deprotonation of the hydrogen addition product before oxidation, especially for the larger bases NEt3 and t-BuNH2.	Hydrogen	93-101	tetraspanin 2	Homo sapiens	169-173
23300027-9	2013	Notably, we noticed the decrease in number of hydrogen bonds between CDK2 and flavopiridol mutant complexes in the whole dynamic period.	Hydrogen	46-54	cyclin dependent kinase 2	Homo sapiens	69-73
19428995-7	2009	Furthermore, intraperitoneal (IP) injection of synthesized goldfish 26RFa/QRFP at a dose of 1 microg/g bodyweight significantly increased serum LH levels at 1h.	Hydrogen	157-159	pyroglutamylated RFamide peptide	Homo sapiens	68-73
19428995-7	2009	Furthermore, intraperitoneal (IP) injection of synthesized goldfish 26RFa/QRFP at a dose of 1 microg/g bodyweight significantly increased serum LH levels at 1h.	Hydrogen	157-159	pyroglutamylated RFamide peptide	Homo sapiens	74-78
22429570-2	2012	Quantitative pharmacophore models were generated using HypoGen module of Discovery Studio 2.1, whereby the best pharmacophore model possessing two hydrophobic, one ring aromatic, and one hydrogen bond acceptor feature for inhibition of acyl coenzyme A cholesterol acyltransferase showed a very good correlation coefficient (r = 0.942) along with satisfactory cost analysis.	Hydrogen	187-195	carboxylesterase 1	Homo sapiens	236-279
22564968-3	2012	The main finding of these studies is that mucin binding to wax disordered slightly the conformation of the hydrocarbon chains of wax and caused the wax carbonyls to become hydrogen bonded or experience a more hydrophilic environment.	Hydrogen	172-180	LOC100508689	Homo sapiens	42-47
23869809-11	2013	At C-8 position, an oxygenated substitution at C-8 is essential for trichothecene toxicity, indicating a decrease in the toxicity if substituent change from isovaleryloxy through hydrogen to the hydroxyl group.	Hydrogen	179-187	homeobox C8	Homo sapiens	47-50
19328688-2	2009	N-Oxide pyridine analog (7b) was identified as a promising FXR agonist with potent binding affinity and good efficacy, supporting our hypothesis that through an additional hydrogen bond interaction between the pyridine substituent of isoxazole analogs and Tyr373 and Ser336 of FXR, binding affinity and functional activity could be improved.	Hydrogen	172-180	nuclear receptor subfamily 1 group H member 4	Homo sapiens	59-62
19328688-2	2009	N-Oxide pyridine analog (7b) was identified as a promising FXR agonist with potent binding affinity and good efficacy, supporting our hypothesis that through an additional hydrogen bond interaction between the pyridine substituent of isoxazole analogs and Tyr373 and Ser336 of FXR, binding affinity and functional activity could be improved.	Hydrogen	172-180	nuclear receptor subfamily 1 group H member 4	Homo sapiens	277-280
18698640-2	2009	It is shown in this work that the chiral-induced equilibrium shift of [Tb(CDA)3](6-) by L-amino acids (i.e. L-proline or L-arginine) was largely influenced by the hydrogen-bonding networks formed between the ligand interface of racemic [Tb(CDA)3](6-) and these added chiral agents.	Hydrogen	163-171	CDAN3	Homo sapiens	74-79
18698640-2	2009	It is shown in this work that the chiral-induced equilibrium shift of [Tb(CDA)3](6-) by L-amino acids (i.e. L-proline or L-arginine) was largely influenced by the hydrogen-bonding networks formed between the ligand interface of racemic [Tb(CDA)3](6-) and these added chiral agents.	Hydrogen	163-171	CDAN3	Homo sapiens	240-245
22535964-2	2012	The structure of Asoprisnil bound to the agonist state of PR demonstrates the contribution of the ligand to increasing stability of the agonist conformation of helix-12 via a specific hydrogen-bond network including Glu(723).	Hydrogen	184-192	progesterone receptor	Homo sapiens	58-60
18698640-3	2009	The capping of potential hydrogen-bonding sites by acetylation in L-proline led to a approximately 100-fold drop in the induced optical activity of the [Tb(CDA)3](6-):N-acetyl-L-proline system.	Hydrogen	25-33	CDAN3	Homo sapiens	156-161
23826519-5	2013	RESULTS: The results demonstrated a marked down-regulation of miR-9 and miR-21 and up-regulation of miR-199 by hydrogen treatment; the expression of Myd88 and IKK-beta was decreased after hydrogen treatment, whereas PDCD4 was increased, and there was no significant change in NF-kappaB expression.	Hydrogen	111-119	MYD88 innate immune signal transduction adaptor	Homo sapiens	149-154
18698640-4	2009	This result suggested that the hydrogen-bonding networks serve as the basis for further noncovalent discriminatory interactions between racemic [Tb(CDA)3](6-) and added L-amino acids.	Hydrogen	31-39	CDAN3	Homo sapiens	148-153
19143551-4	2009	The intermolecular hydrogen-bonding interactions between the adjacent amides of ALA and OXA induce the parallel packing of the CCC planes of corresponding alkyl chains, while the chains are uniaxially oriented in the monolayers of OA and EDA.	Hydrogen	19-27	ectodysplasin A	Homo sapiens	238-241
22543062-13	2012	Furthermore, the up-regulation of cleaved caspase-3, Bax and down-regulation of Bcl-xl expression were blocked by hydrogen treatment.	Hydrogen	114-122	Bcl2-like 1	Rattus norvegicus	80-86
23826519-5	2013	RESULTS: The results demonstrated a marked down-regulation of miR-9 and miR-21 and up-regulation of miR-199 by hydrogen treatment; the expression of Myd88 and IKK-beta was decreased after hydrogen treatment, whereas PDCD4 was increased, and there was no significant change in NF-kappaB expression.	Hydrogen	188-196	MYD88 innate immune signal transduction adaptor	Homo sapiens	149-154
23826519-5	2013	RESULTS: The results demonstrated a marked down-regulation of miR-9 and miR-21 and up-regulation of miR-199 by hydrogen treatment; the expression of Myd88 and IKK-beta was decreased after hydrogen treatment, whereas PDCD4 was increased, and there was no significant change in NF-kappaB expression.	Hydrogen	188-196	programmed cell death 4	Homo sapiens	216-221
23664099-4	2013	Molecular modeling studies suggested the derivatives have bound in the active site of Aurora A kinase through the formation of four hydrogen bonds.	Hydrogen	132-140	aurora kinase A	Homo sapiens	86-94
22590246-2	2012	The dihedral angles between the carboxyl groups and the benzene ring are 64.02 (9) and 21.67 (9) , the larger angle being associated with an intra-molecular N-H O(carbox-yl) hydrogen bond, resulting from proton transfer from the carb-oxy-lic acid group to the quinoline N atom and giving an S(9) ring motif.	Hydrogen	174-182	syntaxin 8	Homo sapiens	32-36
19137564-6	2009	An electron donor-electron acceptor (EDA) mechanism between the carbon of CO(2) and the nitrogen of the heterocycle and weak hydrogen bonds stabilize the complex, with important contributions from dispersion and induction forces.	Hydrogen	125-133	ectodysplasin A	Homo sapiens	37-40
23559439-3	2013	Whereas [(1H O)Cp*IrCl] (4) is formed quantitatively upon treatment with NEt3, the corresponding rhodium compound [(1H O)Cp*RhCl] (5) undergoes tautomerization upon formation of the lambda(5)sigma(4)-phosphinine rhodium(III) complex [(1 OH)Cp*RhCl] (6) as confirmed by single-crystal X-ray diffraction.	Hydrogen	10-12	tetraspanin 2	Homo sapiens	73-77
18930806-5	2009	Compared to PRE, the proportion of CD14+/CD16+ monocytes was 27% greater POST and 49% less at 1H and was associated with changes in the CD16(++bright) pro-inflammatory subtype (p&lt;0.05).	Hydrogen	94-96	CD14 molecule	Homo sapiens	35-39
22486153-10	2012	Hydrogen exchange proceeds in the EX1 regime.	Hydrogen	0-8	FERM domain containing 6	Homo sapiens	34-37
23528042-7	2013	Binding-competition experiments implicated the Kunitz 1, Kunitz 3 and C-terminal domains of TFPI in aptamer binding, a finding that is supported by hydrogen-deuterium exchange experiments, and indicated that aptamer and FXa can bind simultaneously to TFPI.	Hydrogen	148-156	tissue factor pathway inhibitor	Homo sapiens	92-96
22424482-4	2012	Herein, we provide a structure-based model for the tropomyosin-binding domain of CHASM using a combination of hydrogen/deuterium exchange mass spectrometry (HDX-MS) and NMR analyses.	Hydrogen	110-118	smoothelin like 1	Homo sapiens	81-86
19063863-3	2009	Fully differentiated 3T3-L1 adipocytes were treated with 10 microM FCCP for 1h, resulting in increased serine-307 phosphorylation of IRS-1 and decreased insulin-stimulated tyrosine phosphorylation, association of p85alpha subunit of phosphatidylinositol 3-kinase (PI 3-kinase) with IRS-1, decreased insulin-stimulated PI 3-kinase activity and H(3)-2-deoxyglucose (2DOG) uptake.	Hydrogen	76-78	insulin receptor substrate 1	Canis lupus familiaris	133-138
19063863-3	2009	Fully differentiated 3T3-L1 adipocytes were treated with 10 microM FCCP for 1h, resulting in increased serine-307 phosphorylation of IRS-1 and decreased insulin-stimulated tyrosine phosphorylation, association of p85alpha subunit of phosphatidylinositol 3-kinase (PI 3-kinase) with IRS-1, decreased insulin-stimulated PI 3-kinase activity and H(3)-2-deoxyglucose (2DOG) uptake.	Hydrogen	76-78	insulin receptor substrate 1	Canis lupus familiaris	282-287
23563525-5	2013	The PFO PPC-to-pore transition therefore converts TMHs in a dynamic folding intermediate far above the membrane into TMHs that are hydrogen bonded to those of adjacent subunits in the bilayer-embedded beta-barrel.	Hydrogen	131-139	LHFPL tetraspan subfamily member 5	Homo sapiens	50-54
19072118-5	2009	Molecular shape overlay of 3 with a known FAAH inhibitor indicated that these compounds might act as transition-state analogues, forming putative hydrogen bonds with catalytic residues and mimicking the charge distribution of the tetrahedral transition state.	Hydrogen	146-154	fatty-acid amide hydrolase-like	Rattus norvegicus	42-46
22236806-6	2012	Bovine heart CcO has a proton conducting pathway that includes a hydrogen-bond network and a water-channel which, in tandem, connect the positive side phase with the negative side phase.	Hydrogen	65-73	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	13-16
23563525-5	2013	The PFO PPC-to-pore transition therefore converts TMHs in a dynamic folding intermediate far above the membrane into TMHs that are hydrogen bonded to those of adjacent subunits in the bilayer-embedded beta-barrel.	Hydrogen	131-139	LHFPL tetraspan subfamily member 5	Homo sapiens	117-121
19768687-5	2009	Moreover, the newly developed atomic structural refinement algorithm was tested in CASP8 and found to improve the hydrogen-bonding networks and the overall TM-score, which is mainly due to its ability of removing steric clashes so that the models can be generated from cluster centroids.	Hydrogen	114-122	caspase 8	Homo sapiens	83-88
22467566-1	2012	Four- and five-bond heteronuclear J-couplings between the hydrogen H-8 and carbons C-6 and C-2 in a series of 7- and 9-benzyl substituted purine derivaties with variuous substituents in positions 2 and 6 were studied by coupled (13)  C NMR and H,C-HMBC experiments and by DFT calculations.	Hydrogen	58-66	complement C6	Homo sapiens	83-86
23558312-2	2013	Low-energy electron induced chemical modifications of 11-mercaptoundecanoic acid (MUA, HS-(CH2)10-COOH) SAMs deposited on gold were probed in situ as a function of the irradiation energy (&lt;11 eV) by combining two complementary techniques: High Resolution Electron Energy Loss Spectroscopy (HREELS), a surface sensitive vibrational spectroscopy technique, and Electron Stimulated Desorption (ESD) analysis of neutral fragments.	Hydrogen	87-89	methionine adenosyltransferase 1A	Homo sapiens	104-108
18984590-0	2008	Analysis of conformational changes during activation of protein kinase Pak2 by amide hydrogen/deuterium exchange.	Hydrogen	85-93	p21 (RAC1) activated kinase 2	Homo sapiens	71-75
23462097-5	2013	The high stability of RPAR-receptor domain complex stems from the formation of a characteristic pattern of three hydrogen bonds between the peptide C-terminus and the residues in the NRP-1 loop III.	Hydrogen	113-121	neuropilin 1	Homo sapiens	183-188
18563875-12	2008	Studies with an extra hydrogen-bonded ethanol molecule in the model, mimicking the active site of the CYP121 P450, show that the resting state and azole binding structures are close in energy, which may lead to chemical equilibrium between the two structures, as indeed observed with recent protein structural studies that have demonstrated two distinct azole binding mechanisms to P450 heme.	Hydrogen	22-30	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	109-113
18563875-12	2008	Studies with an extra hydrogen-bonded ethanol molecule in the model, mimicking the active site of the CYP121 P450, show that the resting state and azole binding structures are close in energy, which may lead to chemical equilibrium between the two structures, as indeed observed with recent protein structural studies that have demonstrated two distinct azole binding mechanisms to P450 heme.	Hydrogen	22-30	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	382-386
22301880-7	2012	Molecular docking of DATs (1b-4b) with PKCdelta C1b showed that the DATs form hydrogen bonds with the polar residues and backbone of the protein, at the same binding site, as that of DAG and phorbol esters.	Hydrogen	78-86	protein kinase C delta	Homo sapiens	39-47
23132142-4	2013	AHP1 binds AHK5(RD) via a prominent hydrogen bond docking ridge and a hydrophobic patch.	Hydrogen	36-44	histidine-containing phosphotransmitter 1	Arabidopsis thaliana	0-4
22463422-2	2012	In particular, we show that, by using a recently developed nonlocal van der Waals functional and by taking into account hydrogen zero point motion, one can properly describe the zero temperature equation of state, the vibrational spectra, and the dielectric properties of ice at low pressure and of ice VIII, a stable phase between 2 and 60 GPa.	Hydrogen	120-128	cytochrome c oxidase subunit 8A	Homo sapiens	303-307
19043415-3	2008	The crystal structure of MBNL1 ZnF3/4 bound to r(CGCUGU) establishes that both ZnF3 and ZnF4 target GC steps, with site-specific recognition mediated by a network of hydrogen bonds formed primarily with main chain groups of the protein.	Hydrogen	166-174	muscleblind like splicing regulator 1	Homo sapiens	25-30
23562162-6	2013	Surprisingly, both groups had improvements in behavior tests, and normalization of GAG levels in the brain and IDUA injection resulted in detectable levels of enzyme in the brain tissue 1h after administration.	Hydrogen	186-188	iduronidase, alpha-L	Mus musculus	111-115
18775986-8	2008	Therefore, proregion Asp and Glu side chains inhibit the RMAD-4 component of full-length proRMAD-4((20-94)), perhaps by a combination of charge-neutralizing and hydrogen-bonding interactions.	Hydrogen	161-169	neutrophil defensin 6	Macaca mulatta	57-63
22412560-4	2012	These are sustained by O-H N(piperazine) hydrogen bonds, and are connected into the three-dimensional crystal structure by C-H S and C-H O inter-actions.	Hydrogen	41-49	lysosomal trafficking regulator	Homo sapiens	123-136
22209213-7	2012	Besides, real-time PCR and Western blot analysis disclosed that hepatic scavenger receptor class B type I (SR-BI), ATP-binding cassette (ABC) transporters ABCG8, ABCB4, ABCB11, and macrophage SR-BI, were all induced by hydrogen treatment.	Hydrogen	219-227	scavenger receptor class B, member 1	Mus musculus	72-105
23597102-4	2013	At high concentrations (millimolar), E3330 interacts with two regions in the endonuclease active site of APE1, as mapped by hydrogen-deuterium exchange mass spectrometry.	Hydrogen	124-132	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	105-109
22209213-7	2012	Besides, real-time PCR and Western blot analysis disclosed that hepatic scavenger receptor class B type I (SR-BI), ATP-binding cassette (ABC) transporters ABCG8, ABCB4, ABCB11, and macrophage SR-BI, were all induced by hydrogen treatment.	Hydrogen	219-227	scavenger receptor class B, member 1	Mus musculus	192-197
22388820-7	2012	Our structural and biochemical analyses identify the molecular mechanism for UVR8-mediated ultraviolet-B perception, in which ultraviolet-B radiation results in destabilization of the intramolecular cation-pi interactions, causing disruption of the critical intermolecular hydrogen bonds mediated by Arg 286 and Arg 338 and subsequent dissociation of the UVR8 homodimer.	Hydrogen	273-281	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	77-81
22296523-7	2012	To the best of our knowledge, this approach is the first example of specific engineering of successful hydrogen-bonding catalysis into a MOF material.	Hydrogen	103-111	lysine acetyltransferase 8	Homo sapiens	137-140
22252288-1	2012	We report an ultrafast and sensitive hydrogen (H(2)) sensing platform using semiconducting single-walled carbon nanotubes (SWCNTs) decorated with tin oxide (SnO(2)) nanocrystals (NCs).	Hydrogen	37-45	strawberry notch homolog 1	Homo sapiens	157-160
22252288-1	2012	We report an ultrafast and sensitive hydrogen (H(2)) sensing platform using semiconducting single-walled carbon nanotubes (SWCNTs) decorated with tin oxide (SnO(2)) nanocrystals (NCs).	Hydrogen	47-52	strawberry notch homolog 1	Homo sapiens	157-160
22252288-2	2012	The hybrid SnO(2) NC-SWCNT platform shows a response time of 2-3 seconds to 1% H(2) under room temperature and can fully recover within a few minutes in air.	Hydrogen	79-83	strawberry notch homolog 1	Homo sapiens	11-14
22169633-4	2012	A docking study of 54S with our hTRPV1 homology model highlighted crucial hydrogen bonds between the ligand and the receptor contributing to its potency.	Hydrogen	74-82	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-38
23285125-13	2012	This is confirmed by the simulations of hNaa50p/AcCoA/EEE and hNaa10p/AcCoA/MLG, where these hydrogen bonds are still observed.	Hydrogen	93-101	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	62-69
23077523-4	2012	Based on the structure of IDE, Asn 575 was identified as a potential hydrogen bond partner for Cys904 and mutation of this residue also reduced activity and decreased polyanion activation.	Hydrogen	69-77	insulin degrading enzyme	Rattus norvegicus	26-29
22443056-8	2012	The increase of p-HSF1 begining at 1h, up to the peak at 3h; and the increase of HSP70 to the peak at 6h and then recovered to the original level at 24h.	Hydrogen	35-37	heat shock transcription factor 1	Homo sapiens	18-22
22052909-10	2011	15N-1H heteronuclear single quantum coherence experiments identified residues of alphaM and beta2 tails that may be involved in the formation of a tail-tail heterocomplex.	Hydrogen	4-6	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	92-97
22052909-13	2011	Docked structures of tail-tail complexes delineated that the alphaM/beta2 interface at the cytosolic region could be sustained by a network of polar interactions, ionic interactions, and/or hydrogen bonds.	Hydrogen	190-198	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	68-73
22041171-5	2011	Particularly, some of these compounds (e.g., 1b and 1h) showed low nanomolar K(I) values and excellent selectivity for hCA IX and hCA XIV versus hCA I and II inhibition.	Hydrogen	52-54	carbonic anhydrase 9	Homo sapiens	119-125
21409570-5	2011	The docking results for menadione and the lead molecules at the ligand binding site of SBD of Siah2 revealed that the residue Ser39 (corresponding to Ser167 in the full-length protein) is consistently involved in strong hydrogen bonding, and plays an important role in phosphorylation and the enhanced activity of Siah2.	Hydrogen	220-228	siah E3 ubiquitin protein ligase 2	Homo sapiens	94-99
22143461-0	2011	Amide hydrogen/deuterium exchange &amp; MALDI-TOF mass spectrometry analysis of Pak2 activation.	Hydrogen	6-14	p21 (RAC1) activated kinase 2	Homo sapiens	80-84
18937477-5	2008	1H NMR spectroscopy, identification of the catalyst structure, and deuterium-labeling experiments all suggest that reactions catalyzed by 2 and 4 occur by turnover-limiting generation of an eta2-imine complex.	Hydrogen	0-2	DNA polymerase iota	Homo sapiens	190-194
18959747-0	2008	Hydrogen bond residue positioning in the 599-611 loop of thimet oligopeptidase is required for substrate selection.	Hydrogen	0-8	thimet oligopeptidase 1	Homo sapiens	57-78
18706888-0	2008	Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice.	Hydrogen	0-8	regucalcin	Mus musculus	93-98
18706888-0	2008	Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice.	Hydrogen	0-8	regucalcin	Mus musculus	99-102
18706888-2	2008	To clarify the mechanism of hydrogen"s effect in the brain, we administered hydrogen-rich pure water (H(2)) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant.	Hydrogen	28-36	regucalcin	Mus musculus	141-146
18706888-2	2008	To clarify the mechanism of hydrogen"s effect in the brain, we administered hydrogen-rich pure water (H(2)) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant.	Hydrogen	76-84	regucalcin	Mus musculus	141-146
18680750-6	2008	Binding of p19 to p40 is mediated primarily by an arginine residue on helix D of p19 that forms an extensive charge and hydrogen-bonding network with residues at the base of a pocket on p40.	Hydrogen	120-128	interleukin 9	Homo sapiens	18-21
18680750-6	2008	Binding of p19 to p40 is mediated primarily by an arginine residue on helix D of p19 that forms an extensive charge and hydrogen-bonding network with residues at the base of a pocket on p40.	Hydrogen	120-128	interleukin 9	Homo sapiens	186-189
18778097-8	2008	The cellulose I-EDA complex was stable up to a temperature of approximately 130 degrees C, whereas the boiling point of EDA is 117 degrees C. This thermal stability of the complex is probably caused by intermolecular hydrogen bonds between EDA molecules and cellulose.	Hydrogen	217-225	G protein-coupled receptor 149	Homo sapiens	14-19
18600471-1	2008	Unlike photosystem II (PSII) that catalyzes formation of the O-O bond, the cytochromes P450 (P450), members of a superfamily of hemoproteins, catalyze the scission of the O-O bond of dioxygen molecules and insert a single oxygen atom into unactivated hydrocarbons through a hydrogen abstraction-oxygen rebound mechanism.	Hydrogen	274-282	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	87-91
18600471-1	2008	Unlike photosystem II (PSII) that catalyzes formation of the O-O bond, the cytochromes P450 (P450), members of a superfamily of hemoproteins, catalyze the scission of the O-O bond of dioxygen molecules and insert a single oxygen atom into unactivated hydrocarbons through a hydrogen abstraction-oxygen rebound mechanism.	Hydrogen	274-282	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	93-97
18384152-4	2008	In principle, ALTA does not require prior knowledge of known inhibitors, but receptor-based pharmacophore information (hydrogen bonds with the hinge region) is additionally used here to identify molecules with optimal anchor fragments for the ATP-binding site of the EphB4 receptor tyrosine kinase.	Hydrogen	119-127	EPH receptor B4	Homo sapiens	267-272
18657627-6	2008	Treprostinil, inhaled 1h after sildenafil, reduced PVR to 66.3+/-3.8%, mPAP to 77.8+/-3.3%, and increased CO to 107.1+/-3.3% (mean+/-95% confidence interval).	Hydrogen	22-24	phospholipid phosphatase 1	Mus musculus	71-75
18928620-11	2008	At 24, 48 and 72 hours, the expression of Qa-1 on NIH3T3 cells decreased as in the following: H2-T231: 60.9%, 81.9%, 43.6%; H2-T232: 64.5%, 73.9%, 61.1%; H2-T233: 61.9%, 71.2%, 47.5%.	Hydrogen	94-96	histocompatibility 2, T region locus 23	Mus musculus	42-46
18928620-11	2008	At 24, 48 and 72 hours, the expression of Qa-1 on NIH3T3 cells decreased as in the following: H2-T231: 60.9%, 81.9%, 43.6%; H2-T232: 64.5%, 73.9%, 61.1%; H2-T233: 61.9%, 71.2%, 47.5%.	Hydrogen	124-126	histocompatibility 2, T region locus 23	Mus musculus	42-46
18928620-11	2008	At 24, 48 and 72 hours, the expression of Qa-1 on NIH3T3 cells decreased as in the following: H2-T231: 60.9%, 81.9%, 43.6%; H2-T232: 64.5%, 73.9%, 61.1%; H2-T233: 61.9%, 71.2%, 47.5%.	Hydrogen	124-126	histocompatibility 2, T region locus 23	Mus musculus	42-46
18644376-6	2008	In addition, our structural model suggests a hydrogen bond between the hydroxyl group of the aromatic ring of Y8 and the carboxyl group of E496, thus explaining the critical role of the PxxDY motif tyrosine residue in binding to Eps8 family SH3.	Hydrogen	45-53	epidermal growth factor receptor pathway substrate 8	Homo sapiens	229-233
18956096-5	2008	For HB2, the structure of the constituent amino acid residue also plays a crucial role by interfering with the neighboring moieties; (2) the large contribution of the cooperative effect to the overall hydrogen bonding energy has claimed the importance of cooperativity in our systems; (3) the non-hydrogen bonding weak interaction components are found to be non-negligible in these trimer systems; (4) moreover, the cooperative effect between these non-hydrogen bonding components is always found to be positive.	Hydrogen	201-209	keratin 82	Homo sapiens	4-7
18956096-5	2008	For HB2, the structure of the constituent amino acid residue also plays a crucial role by interfering with the neighboring moieties; (2) the large contribution of the cooperative effect to the overall hydrogen bonding energy has claimed the importance of cooperativity in our systems; (3) the non-hydrogen bonding weak interaction components are found to be non-negligible in these trimer systems; (4) moreover, the cooperative effect between these non-hydrogen bonding components is always found to be positive.	Hydrogen	297-305	keratin 82	Homo sapiens	4-7
18956096-5	2008	For HB2, the structure of the constituent amino acid residue also plays a crucial role by interfering with the neighboring moieties; (2) the large contribution of the cooperative effect to the overall hydrogen bonding energy has claimed the importance of cooperativity in our systems; (3) the non-hydrogen bonding weak interaction components are found to be non-negligible in these trimer systems; (4) moreover, the cooperative effect between these non-hydrogen bonding components is always found to be positive.	Hydrogen	297-305	keratin 82	Homo sapiens	4-7
18752964-10	2008	The crucial interaction between the acetate group of the natural sex pheromone and the PBP is most likely to be a hydrogen bonding and the substitution of hydrogen atoms by electronegative atoms in the pheromone molecule reduces the hydrogen acceptor capacity.	Hydrogen	114-122	dedicator of cytokinesis 3	Homo sapiens	87-90
18752964-10	2008	The crucial interaction between the acetate group of the natural sex pheromone and the PBP is most likely to be a hydrogen bonding and the substitution of hydrogen atoms by electronegative atoms in the pheromone molecule reduces the hydrogen acceptor capacity.	Hydrogen	155-163	dedicator of cytokinesis 3	Homo sapiens	87-90
18752964-10	2008	The crucial interaction between the acetate group of the natural sex pheromone and the PBP is most likely to be a hydrogen bonding and the substitution of hydrogen atoms by electronegative atoms in the pheromone molecule reduces the hydrogen acceptor capacity.	Hydrogen	155-163	dedicator of cytokinesis 3	Homo sapiens	87-90
18784102-2	2008	Data from animal models suggest that sodium-hydrogen exchanger regulatory factor 1 (NHERF1) controls renal phosphate transport.	Hydrogen	44-52	SLC9A3 regulator 1	Homo sapiens	84-90
18665614-7	2008	The p K a values of three of four histidine residues (His12, -105, and -119) in RNase A were successfully determined by this method and were in good agreement with those determined by (1)H NMR and hydrogen-tritium exchange methods.	Hydrogen	197-205	ribonuclease A family member 1, pancreatic	Homo sapiens	80-87
18646867-0	2008	Yeast ribonuclease III uses a network of multiple hydrogen bonds for RNA binding and cleavage.	Hydrogen	50-58	ribonuclease III	Saccharomyces cerevisiae S288C	6-22
18538917-0	2008	Solution 1H NMR study of the active site structure for the double mutant H64Q/V68F cyanide complex from mouse neuroglobin.	Hydrogen	9-11	neuroglobin	Mus musculus	110-121
18262646-8	2008	1h after irradiation by the lethal doses 5 and 10 Gy we detected by Western blot a decrease in repair proteins Mre11, Rad50, and Nbs1.	Hydrogen	0-2	RAD50 double strand break repair protein	Homo sapiens	118-123
18262646-9	2008	While phosphorylation of H2A.X 1h after irradiation was detected by both confocal microscopy and Western blot, phosphorylation of Nbs1 on serine 343 was not detectable in MOLT-4 cells.	Hydrogen	31-33	H2A.X variant histone	Homo sapiens	25-30
18507375-1	2008	The organometallic compound trans-(tetrafluoropyrid-2-yl)bis(triethylphosphine)-fluoronickel(II) (NiF) is shown to serve as a strong hydrogen bond and halogen bond acceptor in solution via intermolecular interactions with the fluoride ligand.	Hydrogen	133-141	S100 calcium binding protein A8	Homo sapiens	98-101
19325796-1	2008	Photoinduced biohydrogen production systems, coupling saccharaides biomass such as sucrose, maltose, cellobiose, cellulose, or saccharides mixture hydrolysis by enzymes and glucose dehydrogenase (GDH), and hydrogen production with platinum colloid as a catalyst using the visible light-induced photosensitization of Mg chlorophyll-a (Mg Chl-a) from higher green plant or artificial chlorophyll analog, zinc porphyrin, are introduced.	Hydrogen	16-24	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	173-194
19325796-1	2008	Photoinduced biohydrogen production systems, coupling saccharaides biomass such as sucrose, maltose, cellobiose, cellulose, or saccharides mixture hydrolysis by enzymes and glucose dehydrogenase (GDH), and hydrogen production with platinum colloid as a catalyst using the visible light-induced photosensitization of Mg chlorophyll-a (Mg Chl-a) from higher green plant or artificial chlorophyll analog, zinc porphyrin, are introduced.	Hydrogen	16-24	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	196-199
23530208-7	2013	Polar residues that create a hydrogen bond cluster form one of the anchor points of VMAT2.	Hydrogen	29-37	solute carrier family 18 member A2	Homo sapiens	84-89
23391334-0	2013	Novel molecular platform integrated iron chelation therapy for 1H-MRI detection of beta-galactosidase activity.	Hydrogen	63-65	galactosidase beta 1	Homo sapiens	83-101
23448130-7	2013	H2-transfer to alkynes, olefins, imines, PhN NPh, and ketones was explored, but only stoichiometric reactions were affected.	Hydrogen	0-2	carbamoyl-phosphate synthase 1	Homo sapiens	41-44
23257339-4	2013	The hydrogen bonds and van der Waals forces play a major role in the interaction between OMZH and mucin.	Hydrogen	4-12	LOC100508689	Homo sapiens	98-103
23368960-6	2013	(4) Hydrogen sulfide (H(2)S/HS(-)) inhibits CO oxidation but not CO(2) reduction--the complex on/off characteristics are consistent with it binding at the same oxidation level as C(ox) and forming a modified version of this inactive state rather than reacting directly with C(red1).	Hydrogen	28-30	adenosine deaminase RNA specific B1	Homo sapiens	276-280
23258532-0	2013	Pyruvate:ferredoxin oxidoreductase is coupled to light-independent hydrogen production in Chlamydomonas reinhardtii.	Hydrogen	67-75	uncharacterized protein	Chlamydomonas reinhardtii	9-19
23258532-2	2013	H(2) is generated mostly by the [Fe-Fe]-hydrogenase HYDA1, which uses plant type ferredoxin PETF/FDX1 (PETF) as an electron donor.	Hydrogen	0-4	uncharacterized protein	Chlamydomonas reinhardtii	81-91
23258532-5	2013	PFR1 has long been suggested to be responsible for the low but significant H(2) accumulation in the dark because the catalytic mechanism of pyruvate:ferredoxin oxidoreductase involves the reduction of ferredoxin.	Hydrogen	75-79	uncharacterized protein	Chlamydomonas reinhardtii	149-159
23258532-5	2013	PFR1 has long been suggested to be responsible for the low but significant H(2) accumulation in the dark because the catalytic mechanism of pyruvate:ferredoxin oxidoreductase involves the reduction of ferredoxin.	Hydrogen	75-79	uncharacterized protein	Chlamydomonas reinhardtii	201-211
23320928-5	2013	The groups with hydrogen donor or electron-withdrawing groups at the C-6 position were found to be favorable for antiviral activity.	Hydrogen	16-24	complement C6	Homo sapiens	69-72
18175324-4	2008	Consequently, D151 lying on the 150-loop (residues 147-152) of group-1 neuraminidase (N1, N4, N5, and N8) was considerably shifted to form direct hydrogen bonds with the --OH group of the PRV, which was located rather far from the 150-loop.	Hydrogen	146-154	neuraminidase 1	Homo sapiens	71-84
18270200-3	2008	One of these is Nar1, which intriguingly is homologous to iron-only hydrogenases, ancient enzymes that catalyze the formation of hydrogen gas in anaerobic bacteria.	Hydrogen	68-76	cytosolic iron-sulfur assembly component 3	Homo sapiens	16-20
18384689-7	2008	Chicken PXR possesses a symmetrical pharmacophore with four hydrophobes, a hydrogen bond acceptor, as well as excluded volumes.	Hydrogen	75-83	nuclear receptor subfamily 1 group I member 2	Xenopus tropicalis	8-11
18174163-9	2008	Finally, quantitative structure-activity relationship analysis of the nine antivirals" physicochemical descriptors with their OAT affinity indicates that antiviral preferences of mOat1 are explained by high polar surface areas (e.g. phosphate groups), whereas mOat3 prefers hydrogen bond acceptors (e.g. amines, ketones) and low rotatable bond numbers.	Hydrogen	274-282	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	179-184
18302150-0	2008	Electrostatic stabilization and general base catalysis in the active site of the human protein disulfide isomerase a domain monitored by hydrogen exchange.	Hydrogen	137-145	prolyl 4-hydroxylase subunit beta	Homo sapiens	87-114
18192347-0	2008	Destabilizing mutations alter the hydrogen exchange mechanism in ribonuclease A.	Hydrogen	34-42	ribonuclease A family member 1, pancreatic	Homo sapiens	65-79
18192347-5	2008	Simulation of RNase A hydrogen exchange indicates that the most protected protons in RNase A and the V108G variant exchange via the EX2 regime, whereas those of I106A exchange through a mixed EX1 + EX2 process.	Hydrogen	22-30	ribonuclease A family member 1, pancreatic	Homo sapiens	14-21
18192347-5	2008	Simulation of RNase A hydrogen exchange indicates that the most protected protons in RNase A and the V108G variant exchange via the EX2 regime, whereas those of I106A exchange through a mixed EX1 + EX2 process.	Hydrogen	22-30	ribonuclease A family member 1, pancreatic	Homo sapiens	85-92
18236417-1	2008	1H-1H scalar coupling across two stacked (parallel and eclipsed) aromatic rings has been revealed through the 1D and 2D 1H NMR analysis of a [2,2]paracyclophane and rationalized by means of density functional theory (DFT) calculation of the J values.	Hydrogen	0-2	leiomodin 1	Homo sapiens	110-122
18236417-1	2008	1H-1H scalar coupling across two stacked (parallel and eclipsed) aromatic rings has been revealed through the 1D and 2D 1H NMR analysis of a [2,2]paracyclophane and rationalized by means of density functional theory (DFT) calculation of the J values.	Hydrogen	3-5	leiomodin 1	Homo sapiens	110-122
18179184-0	2008	Ab initio modeling of defect signatures in infrared reflection-absorption spectra of SAMs exposing methyl- and hydrogen-terminated oligo(ethylene glycols).	Hydrogen	111-119	methionine adenosyltransferase 1A	Homo sapiens	85-89
17766341-8	2008	A network of hydrogen-bonded water molecules leading from the bulk water to the zinc-coordinated ligands in the ABP1 binding site was formed in all simulations.	Hydrogen	13-21	amine oxidase copper containing 1	Homo sapiens	112-116
17766341-10	2008	These results suggest that the hydrogen-bonded water molecules may assist in protonation and deprotonation of auxin molecules and their egress from the ABP1 binding site.	Hydrogen	31-39	amine oxidase copper containing 1	Homo sapiens	152-156
19192719-1	2008	The properties and effects of neutral pH hydrogen-enriched electrolyzed water (NHE water) on tumor cells were examined.	Hydrogen	41-49	solute carrier family 9 member C1	Homo sapiens	79-82
19192719-6	2008	In the human oral cavity, a dissolved hydrogen concentrations (DH) of NHE water was drastically declined from 1.1 to 0.5 ppm, but settled to 0.3-0.4 ppm until 180 s, upon static holding without gargling.	Hydrogen	38-46	solute carrier family 9 member C1	Homo sapiens	70-73
17999505-8	2007	This reduction potential corresponds to an overpotential for the reaction of the charge carriers with O2 of approximately 0.6 V. N,N"-1H,1H-Perfluorobutyl derivatives of the perylene-based semiconductors were also synthesized and used to fabricate OFETs, resulting in air-stable devices for all fluorocarbon-substituted materials, despite generally having E(red1) &lt; -0.1 V. This behavior is consistent with a fluorocarbon-based O2 barrier mechanism.	Hydrogen	134-136	adenosine deaminase RNA specific B1	Homo sapiens	358-362
21424594-7	2011	And the major difference about binding mode from the crystal structures of beta(1)- and beta(2)-ARs is the hydrogen-bonding interaction with the residue Arg315, which corresponds to the residue Asn313 of beta(1)-AR and the residue His296 of beta(2)-AR, respectively.	Hydrogen	107-115	adrenoceptor beta 1	Homo sapiens	204-214
22064942-2	2011	The crystal packing features inter-molecular O-H N, O-H O and N-H O hydrogen bonds involving the water mol-ecule and weak C-H O, C-H Cg and pi-pi stacking inter-actions [centroid-centroid distances = 3.8743 (7), 3.7229 (7) and 3.7076 (8) A].	Hydrogen	68-76	non-SMC condensin I complex subunit G	Homo sapiens	122-135
22065715-3	2011	The crystal packing is stabilized by C-H O hydrogen bonds, which generate C(6) chains, and C-H pi inter-actions.	Hydrogen	43-51	complement C6	Homo sapiens	74-78
21718684-6	2011	The proton-pumping pathway of bovine heart cytochrome c oxidase includes a hydrogen-bond network and a water channel located in tandem between the positive and negative side of the mitochondrial membrane.	Hydrogen	75-83	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	43-63
21298564-0	2011	Secondary structure and 1H, 13C, 15N resonance assignments of the Golgi-specific PH domain of FAPP1.	Hydrogen	24-26	pleckstrin homology domain containing A3	Homo sapiens	94-99
21516336-0	2011	1H, 13C and 15N resonance assignment of a 114-residue fragment of Engrailed 2 homeoprotein, a partially disordered protein.	Hydrogen	0-2	engrailed homeobox 2	Homo sapiens	66-77
21872570-4	2011	Also, the Kir channels lack the Trp that hydrogen bonds to Asp80 in KcsA.	Hydrogen	41-49	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	10-13
22058982-4	2011	In the crystal, mol-ecules are linked via inter-molecular C-H N and C-H O hydrogen bonds into a three-dimensional network.	Hydrogen	74-82	chimerin 1	Homo sapiens	58-71
21599856-3	2011	In the present study, we have made a comprehensive analysis on similarities and differences observed in hydrophobic interactions and hydrogen bond interactions of 170 X-ray crystal structures of active and inactive cyclin-dependent kinase-2 (CDK-2) ligand complexes obtained from the Protein Data Bank.	Hydrogen	133-141	cyclin dependent kinase 2	Homo sapiens	215-240
21599856-3	2011	In the present study, we have made a comprehensive analysis on similarities and differences observed in hydrophobic interactions and hydrogen bond interactions of 170 X-ray crystal structures of active and inactive cyclin-dependent kinase-2 (CDK-2) ligand complexes obtained from the Protein Data Bank.	Hydrogen	133-141	cyclin dependent kinase 2	Homo sapiens	242-247
21697807-8	2011	Infusion of the pressor dose decreased, whereas the non-pressor dose of angiotensin II increased the phosphorylation of the sodium and hydrogen exchanger 3 (NHE-3) in membrane fractions of proximal tubules.	Hydrogen	135-143	solute carrier family 9 member A3	Rattus norvegicus	157-162
21717014-3	2011	Our strategy started from its five 2"-deoxyadenosine residues (A5, A9, A11, A12, and A15) in the loop based on the capability of the N7 atom to form hydrogen bonds in tertiary structures.	Hydrogen	149-157	immunoglobulin kappa variable 2D-19 (pseudogene)	Homo sapiens	76-79
21728354-4	2011	Mutagenesis experiments suggest that efficient phosphorylation rates are maintained by an extensive hydrogen bonding and electrostatic network between the RS domain of the SR protein and the active site and docking groove of the kinase.	Hydrogen	100-108	RNA binding protein with serine rich domain 1	Homo sapiens	172-182
21817793-5	2011	Compound (I) forms hydrogen-bonded parallel beta-sheet-like tapes, with the carbonyl groups of Aib1 and Aib2 acting as hydrogen-bond acceptors.	Hydrogen	119-127	ANIB2	Homo sapiens	104-108
21626699-11	2011	Finally, binding to PDZ domains of PSD-95, syntrophin, and DVL3 was studied using 1H,15N HSQC NMR spectroscopy.	Hydrogen	82-84	discs large MAGUK scaffold protein 4	Homo sapiens	35-41
21626699-11	2011	Finally, binding to PDZ domains of PSD-95, syntrophin, and DVL3 was studied using 1H,15N HSQC NMR spectroscopy.	Hydrogen	82-84	dishevelled segment polarity protein 3	Homo sapiens	59-63
21600196-3	2011	Sulfation of the GAG chain is key as evidenced by the renal agenesis phenotype in mice deficient in the HS biosynthetic enzyme, heparan sulfate 2-O sulfotransferase (Hs2st; an enzyme which catalyzes the 2-O-sulfation of uronic acids in heparan sulfate).	Hydrogen	104-106	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	166-171
21723254-5	2011	Hydrogen treatment inhibited LPS/IFNgamma-induced phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) and its downstream signaling molecules, p38 MAP kinase and JNK, as well as IkappaBalpha, but did not affect activation of NADPH oxidase and production of reactive oxygen species (ROS).	Hydrogen	0-8	mitogen-activated protein kinase 14	Mus musculus	153-156
21293445-0	2011	Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice.	Hydrogen	10-18	fibroblast growth factor 21	Mus musculus	69-74
21721644-3	2011	Using the computed solvation free energy of H(+) as reference, the deprotonation and oxidation free energies of an aqueous species can be converted to pK(a) and normal hydrogen electrode (NHE) potentials.	Hydrogen	168-176	solute carrier family 9 member C1	Homo sapiens	188-191
21740154-9	2011	The difference in lactase persistence between populations, even if small, is significant when using individuals concordant for both excretion of breath hydrogen and the lactose tolerance blood glucose test phenotypes (P = 0.018, 25% for Kazakh vs. 11% for Tajiko-Uzbeks), and the difference in frequency of the -13.910*T allele is almost significant (P = 0.06, 30% for Kazakhs vs. 19% for Tajiko-Uzbeks).	Hydrogen	152-160	lactase	Equus caballus	18-25
27467155-8	2011	The hydrogen bond donor feature in the phenol part was a favorable contribution to ERbeta selectivity, whereas the one in the benzopyran part of the ligand was important for ERalpha selectivity.	Hydrogen	4-12	estrogen receptor 2	Homo sapiens	83-89
18004418-4	2007	Nevertheless, the thermal analytical techniques (TGA, DSC and TPD-MS) indicate that the hydrogen has access to the catalyst present and the nickel is able to generate hydrogen species capable of interacting with the support.	Hydrogen	88-96	T-box transcription factor 1	Homo sapiens	49-52
18004418-4	2007	Nevertheless, the thermal analytical techniques (TGA, DSC and TPD-MS) indicate that the hydrogen has access to the catalyst present and the nickel is able to generate hydrogen species capable of interacting with the support.	Hydrogen	88-96	desmocollin 3	Homo sapiens	54-57
18004418-4	2007	Nevertheless, the thermal analytical techniques (TGA, DSC and TPD-MS) indicate that the hydrogen has access to the catalyst present and the nickel is able to generate hydrogen species capable of interacting with the support.	Hydrogen	167-175	T-box transcription factor 1	Homo sapiens	49-52
18004418-4	2007	Nevertheless, the thermal analytical techniques (TGA, DSC and TPD-MS) indicate that the hydrogen has access to the catalyst present and the nickel is able to generate hydrogen species capable of interacting with the support.	Hydrogen	167-175	desmocollin 3	Homo sapiens	54-57
23258275-1	2013	We report the formation of left- (M-helix) and right-handed (P-helix) nanoassemblies of a porphyrin-diaminopurine conjugate (Por-DAP) templated by a single stranded oligodeoxythymidine (dT40) via directional hydrogen bonding.	Hydrogen	208-216	death associated protein	Homo sapiens	129-132
23011899-5	2013	Performing unbiased molecular dynamics simulations, we show that the F76del mutation may enlarge the HIF binding pocket in pVHL and induce the formation of an internal cavity in the hydrophobic core of the beta-domain, which can lead to a partial destabilization of the beta-sheets S1, S4, and S7 and a consequent loss of hydrogen bonds with a conserved recognition motif in HIF.	Hydrogen	322-330	von Hippel-Lindau tumor suppressor	Homo sapiens	123-127
21200685-3	2007	In the crystal structure, weak inter-molecular C-H N and C-H O hydrogen bonds link the mol-ecules into layers parallel to the bc plane.	Hydrogen	63-71	chimerin 1	Homo sapiens	47-60
23220672-9	2013	Hydrogen bonding in protic solvents produces red shifts in Chl a (-60 cm(-1)) and BChl a (-100 cm(-1)), but not in Chl b.	Hydrogen	0-8	chordin like 1	Homo sapiens	59-62
17768618-2	2007	Cultures amended with hydrogen and acetate readily dechlorinated PCE and cis-DCE; however, this transformation was incomplete and resulted in the accumulation of chlorinated intermediates and only small amounts of ethene within 60 days of incubation.	Hydrogen	22-30	24-dehydrocholesterol reductase	Homo sapiens	77-80
23220672-9	2013	Hydrogen bonding in protic solvents produces red shifts in Chl a (-60 cm(-1)) and BChl a (-100 cm(-1)), but not in Chl b.	Hydrogen	0-8	chordin like 1	Homo sapiens	83-86
22964516-6	2013	Further studies revealed increased caspase-9 and caspase-3/7 activation in VSMC beginning as early as 0.5 and 1h following treatment, respectively.	Hydrogen	110-112	caspase 9	Mus musculus	35-44
17705402-1	2007	The oxidation of six derivatives of terfenadone by recombinant human CYP2J2 (CYP = cytochrome P450) was studied by high-performance liquid chromatography coupled to mass spectrometry (MS) using tandem MS techniques and by 1H NMR spectroscopy.	Hydrogen	222-224	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	69-75
23142567-7	2013	The results of a theoretical docking study suggest a binding mode of PI3-K with the hydroxyl groups of the catechol moiety forming hydrogen bonds with the side chains of Asp964 and Asp841 in the p110gamma catalytic subunit.	Hydrogen	131-139	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	195-204
17701062-4	2007	Potentiometric titrations, monitored by UV-vis absorption and electron paramagnetic resonance (EPR) spectroscopy, reveal that the hemes within MtrC titrate over a broad potential range spanning between approximately +100 and approximately -500 mV (vs. the standard hydrogen electrode).	Hydrogen	265-273	OmcA/MtrC family decaheme c-type cytochrome	Shewanella oneidensis MR-1	143-147
17698013-4	2007	Our data support a model in which the gating motion of the TM helices is controlled by an intrasubunit hydrogen bond between TM1 and TM2 at the helix-bundle crossing, and we show that this defines a common gating motif in the Kir channel superfamily.	Hydrogen	103-111	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	226-229
23931275-5	2013	Docking analyses predicted that a hydrogen bond, formed between the 3-hydroxyl group of estradiol and His278 of PDIp"s E2-binding site, is critical for the binding interaction.	Hydrogen	34-42	prolyl 4-hydroxylase subunit beta	Homo sapiens	112-116
17595078-1	2007	Dinuclear eta2,micro2-bonded amidinate complexes to group 13 element hydrides are of potential interest for applications in the field of hydrogen storage.	Hydrogen	137-145	DNA polymerase iota	Homo sapiens	10-14
24148794-9	2013	Moreover, H2 treatment dose-dependently attenuated the increased levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta, HMGB1), but further increased the level of anti-inflammatory cytokine IL-10 at 3 h, 6 h, 12 h and 24 h after LPS stimulation.	Hydrogen	10-12	high mobility group box 1	Homo sapiens	124-129
17636907-1	2007	The peptide group connecting Tyr440 and Ser441 of the bovine cytochrome c oxidase is involved in a recently proposed proton-transfer path (H-path) where, at variance with other pathways (D- and K-paths), a usual hydrogen-bond network is interrupted, thus making this proton propagation rather unconventional.	Hydrogen	212-220	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	61-81
23824069-7	2013	Hydrogen deuterium exchange mass spectrometry shows that the p84 adaptor subunit interacts with the p110gamma helical domain, and reveals an unexpected mechanism of PI3Kgamma regulation.	Hydrogen	0-8	THO complex 1	Homo sapiens	61-64
17568454-1	2007	The 1H and 13C NMR data for 3-azabicyclo[3.3.1]nonanes having C-1 methylsuccinimidoanthranilate esters and C-6 methyl ethers were measured and assigned using 1D (DEPT) and 2D (COSY, HSQC, HMBC, NOESY) experiments.	Hydrogen	4-6	complement C6	Homo sapiens	62-110
23484001-9	2013	This decreased the damage of PAHs to hydrogen bonds in double-stranded DNA by isolating DNA molecules from PAHs and consequently enhanced the transformation efficiency of DNA exposed to PAH contaminants.	Hydrogen	37-45	phenylalanine hydroxylase	Homo sapiens	29-32
17678282-3	2007	As a result, the value of the induced pseudoscalar coupling, g(P)(exp), extracted from a recent hydrogen 1S singlet capture experiment is increased by about 21% to g(P)(exp)=7.3+/-1.2 and brought into good agreement with the prediction of chiral perturbation theory, g(P)(theory)=8.2+/-0.2.	Hydrogen	96-107	muscleblind like splicing regulator 1	Homo sapiens	66-69
17678282-3	2007	As a result, the value of the induced pseudoscalar coupling, g(P)(exp), extracted from a recent hydrogen 1S singlet capture experiment is increased by about 21% to g(P)(exp)=7.3+/-1.2 and brought into good agreement with the prediction of chiral perturbation theory, g(P)(theory)=8.2+/-0.2.	Hydrogen	96-107	muscleblind like splicing regulator 1	Homo sapiens	124-127
17566136-2	2007	The reaction is a complex process that involves, in the first stage, a pre-reactive hydrogen-bonded complex (C1), which is formed previous to two transition states (TS1 and TS2) involving the addition of the hydroxyl radical to ozone, and leads to the formation of HO4 polyoxide radical before the release of the products HO2 and O2.	Hydrogen	84-92	heme oxygenase 2	Homo sapiens	322-325
23457571-0	2013	Amide proton solvent protection in amylin fibrils probed by quenched hydrogen exchange NMR.	Hydrogen	69-77	islet amyloid polypeptide	Homo sapiens	35-41
19636817-0	2007	1H, 13C, and 15N resonance assignments of subunit F of the A(1)A (O) ATP synthase from Methanosarcina mazei Go1.	Hydrogen	0-2	hypothetical protein	Methanosarcina mazei Go1	69-81
19636819-0	2007	1H, 13C and 15N resonance assignments for proapoptotic protein Nix (residue 1 approximately 156) from Danio rerio.	Hydrogen	0-2	BCL2 interacting protein 3 like a	Danio rerio	63-66
23121134-4	2013	The molecular docking showed that hydrogen-bond and hydrophobic interactions were the major driving forces for the binding of ligands to AhR, and several key amino acid residues were also identified.	Hydrogen	34-42	aryl hydrocarbon receptor	Homo sapiens	137-140
19636819-2	2007	Here we reported the 1H, 13C and 15N resonance assignments of zebrafish Nix protein for further understanding the structure and function relationship.	Hydrogen	21-23	BCL2 interacting protein 3 like a	Danio rerio	72-75
19636821-0	2007	1H, 13C, and 15N assignment of the muscular LIM protein MLP/CRP3.	Hydrogen	0-2	cysteine and glycine rich protein 3	Homo sapiens	56-59
19636821-0	2007	1H, 13C, and 15N assignment of the muscular LIM protein MLP/CRP3.	Hydrogen	0-2	cysteine and glycine rich protein 3	Homo sapiens	60-64
19636837-0	2007	Backbone and sidechain 1H, 13C and 15N resonance assignments of the RGS domain from human RGS14.	Hydrogen	23-25	regulator of G protein signaling 14	Homo sapiens	90-95
19636837-1	2007	We have assigned 1H, 13C and 15N resonances of the RGS domain from the human RGS14 protein, a multi-domain member of the RGS (Regulators of G-protein signalling) family of proteins, important in the down-regulation of specific G-protein signalling pathways.	Hydrogen	17-19	regulator of G protein signaling 14	Homo sapiens	77-82
21643454-1	2011	Discovery of EX1 kinetics in hydrogen exchange (HX) mass spectrometry (MS) experiments is rare.	Hydrogen	29-37	FERM domain containing 6	Homo sapiens	13-16
23276293-8	2013	Protein-protein docking investigation of P16-INK4 revealed four ionic bonds illustrating Arg47, Arg80,Cys72 and Met1 residues as actively participating in interactions with CDK4 while docking results of RB1 showed four hydrogen bonds involving Glu864, Ser567, Asp36 and Arg861 residues which interact strongly with its respective functional interactor E2F1.	Hydrogen	219-227	RB transcriptional corepressor 1	Homo sapiens	203-206
21125132-2	2011	The structures based on zeolitic rho, gme and fau nets are shown to be stable and have high total hydrogen uptake (6.9-7.8 wt.%) comparable with that of MOF-177.	Hydrogen	98-106	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	46-49
17586773-1	2007	The role of hither-to-fore unrecognized long-range hydrogen bonds between main-chain amide hydrogens and polar side chains on the stability of a well-studied (betaalpha)8, TIM barrel protein, the alpha subunit of tryptophan synthase (alphaTS), was probed by mutational analysis.	Hydrogen	51-59	Rho guanine nucleotide exchange factor 5	Homo sapiens	172-175
17586773-6	2007	Kinetic studies suggest that the three clamp hydrogen bonds act in concert to stabilize the transition state leading to the fully folded TIM barrel motif.	Hydrogen	45-53	Rho guanine nucleotide exchange factor 5	Homo sapiens	137-140
23126503-4	2012	In addition, docking experiments and molecular dynamics (MD) simulations showed that the complex binds via hydrogen bonding (HB), to an allosteric site of LOX-1, revealing that this enzyme has more than one accessible site for complex metallotherapeutic molecules.	Hydrogen	107-115	oxidized low density lipoprotein receptor 1	Homo sapiens	155-160
17470807-7	2007	The model identifies key ionic and hydrophobic interactions at the binding interface, including hydrogen-bonding between His-87 of actin to Ser-89 of cofilin that may control the charge dependence of cofilin binding.	Hydrogen	96-104	cofilin 1	Homo sapiens	150-157
17470807-7	2007	The model identifies key ionic and hydrophobic interactions at the binding interface, including hydrogen-bonding between His-87 of actin to Ser-89 of cofilin that may control the charge dependence of cofilin binding.	Hydrogen	96-104	cofilin 1	Homo sapiens	200-207
20703835-0	2011	The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing.	Hydrogen	4-6	serine and arginine rich splicing factor 2	Homo sapiens	76-80
23076806-1	2012	Undoped nanostructured tin oxide (SnO(2)) arrays were prepared on oxidized Si substrates by nanosecond pulsed laser interference irradiation for hydrogen gas sensing applications.	Hydrogen	145-153	strawberry notch homolog 1	Homo sapiens	34-37
21147246-7	2011	Shorter sampling intervals of 1h in the morning when lights were switched gradually on and food was offered to the larvae demonstrated a marked drop in the relative gut CCK levels and a concurrent increase in the CCK carcass to gut ratio, 1h after introduction of food followed by a return to prefeeding levels after 2h.	Hydrogen	30-32	cholecystokinin a	Clupea harengus	169-172
21147246-7	2011	Shorter sampling intervals of 1h in the morning when lights were switched gradually on and food was offered to the larvae demonstrated a marked drop in the relative gut CCK levels and a concurrent increase in the CCK carcass to gut ratio, 1h after introduction of food followed by a return to prefeeding levels after 2h.	Hydrogen	30-32	cholecystokinin a	Clupea harengus	213-216
17425297-3	2007	X-ray crystal structures of complexes of nNOS with two nNOS-selective inhibitors, (4S)-N-{4-amino-5-[(2-aminoethylamino]pentyl}-N"-nitroguanidine (1) and 4-N-(Nomega-nitro-l-argininyl)-trans-4-amino-l-proline amide (2), led to the discovery of a conserved structural water molecule that was hydrogen bonded between the two heme propionates and the inhibitors (Figure 2).	Hydrogen	291-299	nitric oxide synthase 1	Homo sapiens	41-45
23076806-4	2012	The observed electrical response of SnO(2) towards hydrogen at low concentrations and room temperature drastically improved in the nanostructured array as compared to the thin film.	Hydrogen	51-59	strawberry notch homolog 1	Homo sapiens	36-39
17408804-1	2007	The present studies assessed the extent to which the adiposity signal leptin and the brain-gut hormone cholecystokinin (CCK), administered alone or in combination, give rise to interoceptive sensory cues like those that are produced by a low (1h) level of food deprivation.	Hydrogen	243-245	leptin	Rattus norvegicus	70-76
23076806-5	2012	The results suggest that this method to fabricate SnO(2) nanostructured arrays has the potential to produce nanodevices that have ultra-low detection limits, and fast response and recovery times, which are suited for practical hydrogen sensing applications.	Hydrogen	227-235	strawberry notch homolog 1	Homo sapiens	50-53
21266166-6	2011	Incubation of wild-type extensor digitorum longus muscles for 1h with the ATM inhibitor KU55933 caused a ~50% reduction (P&lt;0.05, n = 5/group) in COX activity compared to muscles incubated with vehicle alone.	Hydrogen	62-64	ataxia telangiectasia mutated	Mus musculus	74-77
22899869-8	2012	The potency of MPEP was also greatly affected by S809A (52-fold), suggesting that a Ser809-mediated hydrogen bond is also a key interaction between MPEP and mGluR5.	Hydrogen	100-108	glutamate receptor, ionotropic, kainate 1	Mus musculus	157-163
17388541-6	2007	For the reaction in solution, it is found that the hydrogen bond network near the reaction center undergoes a significant change, and there is a strong shift in electrostatic field from the prereaction state to the transition state, whereas for the enzyme reaction, such an effect is much smaller and the enzyme SET7/9 is found to provide a preorganized electrostatic environment to facilitate the methyl-transfer reaction.	Hydrogen	51-59	PR/SET domain containing protein 7	Drosophila melanogaster	312-318
23074198-4	2012	We hypothesized that CAIX contributes to the extrusion of hydrogen ions into the extracellular space, thereby moderating intra- and extracellular pH and creating an environment conductive to enhanced invasion.	Hydrogen	58-66	carbonic anhydrase 9	Homo sapiens	21-25
17360500-1	2007	X-ray structures of bovine heart cytochrome c oxidase have suggested that the enzyme, which reduces O(2) in a process coupled with a proton pumping process, contains a proton pumping pathway (H-pathway) composed of a hydrogen bond network and a water channel located in tandem across the enzyme.	Hydrogen	217-225	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	33-53
17302499-0	2007	Photoelectrochemical reaction and H2 generation at zero bias optimized by carrier concentration of n-type GaN.	Hydrogen	34-36	gigaxonin	Homo sapiens	106-109
17092635-8	2007	Following a 1h exposure to 500 nM STC-1, mitochondria from both organs displayed significant increases in respiration rate as compared to controls.	Hydrogen	12-14	stanniocalcin 1	Homo sapiens	34-39
17038435-2	2007	Pulsed-field gradient NMR methods have now followed gradient-dependent changes in the distinct 1H NMR gamma CH3 Val E11 signal of MbO2 in perfused rat myocardium to obtain the endogenous Mb translational diffusion coefficient (D(Mb)) of 4.24 x 10(-7) cm2 s(-1) at 22 degrees C. The D(Mb) matches precisely the value predicted by in vivo NMR rotational diffusion measurements of Mb and shows no orientation preference.	Hydrogen	95-97	myoglobin	Rattus norvegicus	130-132
17041908-8	2007	We postulate that presentation of charged, hydrogen bonding and hydrophobic structural elements within the disulfide-constrained peptide drives IL5Ralpha recruitment by AF17121.	Hydrogen	43-51	interleukin 5 receptor subunit alpha	Homo sapiens	144-153
17041908-9	2007	We hypothesize from these results and previous receptor mutagenesis studies that Arg 6 recruitment of IL5Ralpha occurs through hydrogen bonding as well as charge-charge interactions with Asp 55 in site one of domain 1 of IL5Ralpha, and that this interaction is complemented by additional charged and hydrophobic interactions around the Asp 55 locus.	Hydrogen	127-135	interleukin 5 receptor subunit alpha	Homo sapiens	102-111
17661322-6	2007	These were predicted to undergo intramolecular hydrogen-atom transfer to form [VO(OH)2(eta1-OCHR)]- followed by eta1-O--&gt;eta2-C,O rearrangements to form [VO(OH)2(eta2-OCHR)]-.	Hydrogen	47-55	DNA polymerase iota	Homo sapiens	124-128
17661322-6	2007	These were predicted to undergo intramolecular hydrogen-atom transfer to form [VO(OH)2(eta1-OCHR)]- followed by eta1-O--&gt;eta2-C,O rearrangements to form [VO(OH)2(eta2-OCHR)]-.	Hydrogen	47-55	DNA polymerase iota	Homo sapiens	165-169
17219454-0	2007	Hydrogen-atom transfer in open-shell organometallic chemistry: the reactivity of Rh(II)(cod) and Ir(II)(cod) radicals.	Hydrogen	0-8	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	81-92
17219454-0	2007	Hydrogen-atom transfer in open-shell organometallic chemistry: the reactivity of Rh(II)(cod) and Ir(II)(cod) radicals.	Hydrogen	0-8	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	88-91
17219454-12	2007	The kinetic data are in agreement with bimolecular hydrogen-atom transfer from M(II)(cod) to another M(II) species (DeltaH( not equal)=11.5+/-2 kcal mol(-1), DeltaS( not equal)=-27+/-10 cal K(-1) mol(-1), and DeltaG( not equal)(298 K)=19.5+/-5 kcal mol(-1)).	Hydrogen	51-59	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	85-88
17492819-0	2007	Low-temperature adsorption/storage of hydrogen on FAU, MFI, and MOR zeolites with various Si/Al ratios: effect of electrostatic fields and pore structures.	Hydrogen	38-46	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	50-53
17143275-2	2007	Here we generated a soluble mutant HLA-DR1 with a histidine-to-asparagine substitution at position 81 of the beta-chain (DR1betaH81N) to perturb an important hydrogen bond between MHC class II and peptide.	Hydrogen	158-166	down-regulator of transcription 1	Homo sapiens	39-42
17143275-2	2007	Here we generated a soluble mutant HLA-DR1 with a histidine-to-asparagine substitution at position 81 of the beta-chain (DR1betaH81N) to perturb an important hydrogen bond between MHC class II and peptide.	Hydrogen	158-166	down-regulator of transcription 1	Homo sapiens	121-132
17143275-4	2007	Reintroduction of an appropriate hydrogen bond (DR1betaH81N betaV85H) restored DM-mediated peptide dissociation.	Hydrogen	33-41	down-regulator of transcription 1	Homo sapiens	48-59
17140233-1	2006	The isomerization of complex [Cp*Fe(dppe)(eta2-H2)]+, generated in situ by low-temperature protonation of Cp*Fe(dppe)H with either HBF4 or CF3COOH, to the dihydride tautomer trans-[Cp*Fe(dppe)(H)2]+ is irreversible and follows first-order kinetics in the -10 to +15 degrees C range with Delta H double dagger = 21.6 +/- 0.8 kcal mol(-1) and DeltaS double dagger = 5 +/- 3 eu.	Hydrogen	47-49	DNA polymerase iota	Homo sapiens	42-46
17128986-4	2006	Sequence alignment and homology modeling of the CvaB nucleotide-binding domain predicted that the aromatic stacking region of CvaB (Y501DSQ loop) had a role in the differential binding of nucleotides, and Ser503 and Gln504 provided potential hydrogen bonds to GTP but not to ATP.	Hydrogen	242-250	CvaB	Escherichia coli	48-52
17128986-4	2006	Sequence alignment and homology modeling of the CvaB nucleotide-binding domain predicted that the aromatic stacking region of CvaB (Y501DSQ loop) had a role in the differential binding of nucleotides, and Ser503 and Gln504 provided potential hydrogen bonds to GTP but not to ATP.	Hydrogen	242-250	CvaB	Escherichia coli	126-130
17249202-11	2006	1H MRS can monitor the early stage metabolic changes of HCC after TACE but limitation like quantification still exists.	Hydrogen	0-2	HCC	Homo sapiens	56-59
17028274-7	2006	With MeGAXn from sweetgum as a preferred substrate, XynC exhibited a Vmax of 59.9 units/mg XynC, a Km of 1.63 mg MeGAXn/ml, and a k(cat) of 2,635/minute at pH 6.0 and 37 degrees C. Matrix-assisted laser desorption ionization-time of flight mass spectrometry and 1H nuclear magnetic resonance data revealed that each hydrolysis product has a single glucuronosyl substitution penultimate to the reducing terminal xylose.	Hydrogen	262-264	secreted endo-xylanase	Bacillus subtilis subsp. subtilis str. 168	52-56
17028274-7	2006	With MeGAXn from sweetgum as a preferred substrate, XynC exhibited a Vmax of 59.9 units/mg XynC, a Km of 1.63 mg MeGAXn/ml, and a k(cat) of 2,635/minute at pH 6.0 and 37 degrees C. Matrix-assisted laser desorption ionization-time of flight mass spectrometry and 1H nuclear magnetic resonance data revealed that each hydrolysis product has a single glucuronosyl substitution penultimate to the reducing terminal xylose.	Hydrogen	262-264	secreted endo-xylanase	Bacillus subtilis subsp. subtilis str. 168	91-95
17112254-2	2006	The key step is found to be the abstraction of the hydrogen atom resulting in the formation of a PdI/HO2 (triplet) radical pair, which then proceeds to form a singlet palladium hydroperoxo species.	Hydrogen	51-59	prolyl 4-hydroxylase subunit beta	Homo sapiens	97-100
17112254-2	2006	The key step is found to be the abstraction of the hydrogen atom resulting in the formation of a PdI/HO2 (triplet) radical pair, which then proceeds to form a singlet palladium hydroperoxo species.	Hydrogen	51-59	heme oxygenase 2	Homo sapiens	101-104
17042485-1	2006	Crystal structures of 6-phosphogluconate dehydrogenase (6PGDH) from sheep liver indicate that S128 and N187 are within hydrogen-bonding distance of 6PG in the E:6PG binary complex and NADPH in the E:NADPH binary complex.	Hydrogen	43-51	6-phosphogluconate dehydrogenase, decarboxylating	Ovis aries	56-61
17032756-3	2006	1H-1H NOE buildup measurements were performed for the 472-kDa complex of the 72-kDa cochaperonin GroES with a 400-kDa single-ring variant of the chaperonin GroEL (SR1).	Hydrogen	0-2	heat shock protein family E (Hsp10) member 1	Homo sapiens	97-102
17032756-3	2006	1H-1H NOE buildup measurements were performed for the 472-kDa complex of the 72-kDa cochaperonin GroES with a 400-kDa single-ring variant of the chaperonin GroEL (SR1).	Hydrogen	3-5	heat shock protein family E (Hsp10) member 1	Homo sapiens	97-102
17017773-1	2006	Oxidation of Cp*Ir((rac-TsDPEN)H (DPEN = H2NCHPhCHPhNTs) with Cp2FePF6 or Ph3CPF6 in MeCN solution generates [Cp*Ir(TsDPEN)(NCMe)]PF6 ([1H(NCMe)]PF6) together with H2 and Ph3CH, respectively.	Hydrogen	41-43	sperm associated antigen 17	Homo sapiens	67-70
17017773-1	2006	Oxidation of Cp*Ir((rac-TsDPEN)H (DPEN = H2NCHPhCHPhNTs) with Cp2FePF6 or Ph3CPF6 in MeCN solution generates [Cp*Ir(TsDPEN)(NCMe)]PF6 ([1H(NCMe)]PF6) together with H2 and Ph3CH, respectively.	Hydrogen	41-43	sperm associated antigen 17	Homo sapiens	78-81
17073575-1	2006	CYP2B6 metabolizes a number of drug substrates, that are usually non-planar, neutral or weakly basic, fairly lipophilic with one or two hydrogen bond acceptors, on which it catalyses various oxidative reactions.	Hydrogen	136-144	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-6
16982895-5	2006	A specific hydrogen-bonding network between PIM2 and CD1d orients the headgroup in the center of the binding groove and above the A" pocket.	Hydrogen	11-19	proviral integration site 2	Mus musculus	44-48
16673402-6	2006	The model also predicted that Tyr66 forms hydrogen bond with the phosphate moiety of PLP and interacts with the side chain attached to beta-carbon of the amino acid substrate.	Hydrogen	42-50	pyridoxal phosphatase	Homo sapiens	85-88
16819819-8	2006	Using this approach, amide hydrogen exchange kinetics were measured for regions comprising 78% of the MnSOD backbone.	Hydrogen	27-35	superoxide dismutase 2	Homo sapiens	102-107
16611635-4	2006	M1 aminopeptidases recognize the N-terminal amino group of substrates or inhibitors through hydrogen-bonding to two conserved residues (Gln-213 and exopeptidase motif Glu-355 in human APN), whereas interactions involved in recognition of pyroglutamyl residue by PPII are unknown.	Hydrogen	92-100	alanyl aminopeptidase, membrane	Homo sapiens	184-187
21094126-8	2011	Hydrogen/deuterium (H/D) exchange of the RNase A C-dimer reveal that the H-bonds formed between the swapped C-terminal beta-strand and the other subunit are strong.	Hydrogen	0-8	ribonuclease A family member 1, pancreatic	Homo sapiens	41-48
21186389-3	2011	Variable temperature 1H NMR investigations on [W(C=CH2)(dppe)(eta-C7H7)][PF6], 3, estimate the energy barrier to rotation about the W=C(alpha) bond as 62.5 +- 2 kJ mol-1; approximately 10 kJ mol-1 greater than for the molybdenum analogue.	Hydrogen	21-23	endothelin receptor type A	Homo sapiens	62-65
21542288-4	2011	The pharmacophore of FTIs is constituted by a hydrogen bonding acceptor, an aromatic ring, a positive ionizable and two hydrophobic regions; the pharmacophore of Raf-1 kinase is constituted by a hydrogen donor, a hydrogen acceptor, a hydrophobic regions and an aromatic ring.	Hydrogen	46-54	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	162-167
21542288-4	2011	The pharmacophore of FTIs is constituted by a hydrogen bonding acceptor, an aromatic ring, a positive ionizable and two hydrophobic regions; the pharmacophore of Raf-1 kinase is constituted by a hydrogen donor, a hydrogen acceptor, a hydrophobic regions and an aromatic ring.	Hydrogen	195-203	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	162-167
21542288-4	2011	The pharmacophore of FTIs is constituted by a hydrogen bonding acceptor, an aromatic ring, a positive ionizable and two hydrophobic regions; the pharmacophore of Raf-1 kinase is constituted by a hydrogen donor, a hydrogen acceptor, a hydrophobic regions and an aromatic ring.	Hydrogen	195-203	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	162-167
21404492-10	2011	CONCLUSIONS: The pilot study confirmed that examination of fat content using 1H MRS at 3T is well tolerated by patients.	Hydrogen	77-79	FAT atypical cadherin 1	Homo sapiens	59-62
21404492-11	2011	Significant correlation was found between the results of histology and 1H MRS measurement of liver fat content.	Hydrogen	71-73	FAT atypical cadherin 1	Homo sapiens	99-102
22242116-7	2011	The nuclear gene disrupted in the high H2 producing mutant stm6glc4 encodes for the mitochondrial transcription termination factor (mTERF) MOC1, whose expression strongly increases during -S-induced H2 production in WT strains.	Hydrogen	39-41	tripartite motif-containing 17	Mus musculus	132-137
22242116-7	2011	The nuclear gene disrupted in the high H2 producing mutant stm6glc4 encodes for the mitochondrial transcription termination factor (mTERF) MOC1, whose expression strongly increases during -S-induced H2 production in WT strains.	Hydrogen	199-201	tripartite motif-containing 17	Mus musculus	132-137
21853086-8	2011	Hydrogen-deuterium exchange in Galphai1[ ] bound to Ric-8A is 1.5-fold more extensive than in Galphai1 GDP.	Hydrogen	0-8	RIC8 guanine nucleotide exchange factor A	Homo sapiens	52-58
21829511-10	2011	These results suggested that a hydrogen bond between the L4/5 and L6/7 modulates the overall structure of the exposed surface of the CA, but the amino acid residue at position 120 is also directly involved in CM TRIM5alpha recognition.	Hydrogen	31-39	tripartite motif-containing protein 5	Macaca fascicularis	212-222
21698148-5	2011	Moreover, an application of hydrogen bonding penalty into a high throughput docking campaign for EphB4 inhibitors is presented, and remarkably, three novel scaffolds are discovered out of seven tested.	Hydrogen	28-36	EPH receptor B4	Homo sapiens	97-102
21557925-6	2011	Cumulative analysis of all genes (SC4MOL, HSP1A1A, SOD2 and GPX4) revealed a similar pattern of expression, with a tendency for peak transcript abundance 1h after HP treatment.	Hydrogen	154-156	methylsterol monooxygenase 1	Bos taurus	34-40
21522521-2	2010	Intra-molecular C-H N and C-H O hydrogen bonds occur.	Hydrogen	32-40	chimerin 1	Homo sapiens	16-29
20961754-6	2010	The excellent performance of CoMFA to the affinity differences among these compounds was attributed to the contributions of electrostatic/hydrogen-bonding and steric/hydrophobic interactions, which was supported by the Surflex-Dock and CDOCKER molecular-docking simulations based on the 3D model of NOP built by the homology modeling method.	Hydrogen	138-146	opioid related nociceptin receptor 1	Homo sapiens	299-302
20655199-1	2010	High purity hydrogen (&gt;95%) was produced at 600 degrees C and 1 atm by steam reforming of waste cooking oil at a molar steam to carbon ratio of 4 using chemical looping, a process that features redox cycles of a Ni catalyst with the in-situ carbonation/calcination of a CO(2) sorbent (dolomite) in a packed bed reactor under alternated feedstreams of fuel-steam and air.	Hydrogen	12-20	cullin associated and neddylation dissociated 1	Homo sapiens	59-66
20728510-5	2010	The most obvious attenuation of occludin, claudin-5 and F-actin protein was observed at 1h after papaverine perfusion, companied by a significant decrease in expression levels of PKA protein.	Hydrogen	88-90	occludin	Rattus norvegicus	32-40
20728510-5	2010	The most obvious attenuation of occludin, claudin-5 and F-actin protein was observed at 1h after papaverine perfusion, companied by a significant decrease in expression levels of PKA protein.	Hydrogen	88-90	claudin 5	Rattus norvegicus	42-51
21151444-6	2010	Hydrogen has unconventional values of IC and X(IC), lower than that of boron.	Hydrogen	0-8	X chromosome inactivation center	Homo sapiens	45-50
20354830-0	2010	1H, 13C, and 15N resonance assignment of the TIR domain of human MyD88.	Hydrogen	0-2	MYD88 innate immune signal transduction adaptor	Homo sapiens	65-70
20407887-0	2010	1H, 13C, 15N backbone NMR assignments of the Staphylococcus aureus small multidrug-resistance pump (Smr) in a functionally active conformation.	Hydrogen	0-2	multidrug resistance efflux protein Smr	Staphylococcus aureus	100-103
20455034-0	2010	Backbone and side chain 1H, 15N and 13C assignments for a thiol-disulphide oxidoreductase from the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125.	Hydrogen	24-26	PSHA_RS10305	Pseudoalteromonas haloplanktis TAC125	75-89
21137824-2	2010	The structure and purity of TR1 were carefully characterized by 1H NMR, UV/vis and photoluminescent spectroscopy, mass spectroscopy, and thermal analyses.	Hydrogen	64-66	taste 1 receptor member 1	Homo sapiens	28-31
20580928-5	2010	Genetic deletion of a functional Nox1 lead to a 55% attenuation in lesion size at 24h after induction of 1h ischemia (p&lt;0.05).	Hydrogen	105-107	NADPH oxidase 1	Mus musculus	33-37
20639133-8	2010	In the wild type betaB2-crystallin (WT), only about 20% of the backbone amide hydrogen was exchanged, suggesting an overall low accessibility of betaB2-crystallin in solution.	Hydrogen	78-86	crystallin beta B2	Homo sapiens	17-34
20936717-0	2010	[Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice].	Hydrogen	12-20	high mobility group box 1	Mus musculus	45-70
20936717-6	2010	Hydrogen gas treatment increased the 7-d survival rate of severe CLP mice to 60 % (Compared with severe sepsis group, P &lt;0.05) and significantly reduced the serum HMGB1 levels at different time points (Compared with severe sepsis group, P &lt;0.05).	Hydrogen	0-8	high mobility group box 1	Mus musculus	166-171
20307581-0	2010	Regional metabolic alteration of Alzheimer"s disease in mouse brain expressing mutant human APP-PS1 by 1H HR-MAS.	Hydrogen	103-105	presenilin 1	Homo sapiens	96-99
20520869-0	2010	"(eta(6)-arene)Ru(bis-NHC)" complexes for the reduction of CO(2) to formate with hydrogen and by transfer hydrogenation with iPrOH.	Hydrogen	81-89	endothelin receptor type A	Homo sapiens	2-5
20520869-2	2010	The use of one of the "(eta(6)-arene)Ru(bis-NHC)" complexes (labeled as 1 in the text) in the reduction of carbon dioxide with hydrogen affords a maximum TON value of 23000 at 200 degrees C. The same complexes were used in the reduction of carbon dioxide with iPrOH by the transfer hydrogenation methodology.	Hydrogen	127-135	endothelin receptor type A	Homo sapiens	24-27
16632350-5	2006	X-ray co-crystallization studies with mutated p38alpha showed that these trisubstituted ureas interact with the ATP-binding pocket in a pseudo-bicyclic conformation brought about by the presence of an intramolecular hydrogen bonding interaction.	Hydrogen	216-224	mitogen activated protein kinase 14	Rattus norvegicus	46-54
16804578-4	2006	Successive treatment of [Ru(eta2-BH4)(CO)HL2], , with ethene and then CO yields propanal, but turning this into a catalytic cycle is hindered by the greater readiness of to yield propanal non-catalytically (reacting with CO) than catalytically (reacting with H2).	Hydrogen	259-261	DNA polymerase iota	Homo sapiens	28-32
23023805-1	2012	There"s something in the air ... A nanocomposite consisting of well-dispersed SnO(2) and Pt nanoparticles on reduced graphene oxide (see the high-resolution TEM image) exhibited very high responses to hydrogen at concentrations between 0.5 and 3% in air, with response times of 3-7 s and recovery times of 2-6 s. The sensor was prepared by a straightforward microwave-assisted non-aqueous sol-gel approach.	Hydrogen	201-209	strawberry notch homolog 1	Homo sapiens	78-81
16640382-4	2006	In this study, conceptual DFT tools such as local hardness, eta(r) and local softness, s(r), have been used in order to get an alternative view on solving this hydrogen-bonding puzzle as described by Gilli et al.	Hydrogen	160-168	endothelin receptor type A	Homo sapiens	60-66
16410407-11	2006	The key coupling residues Tyr144/Lys147 (Ci2) are predicted to orient internally, forming hydrogen and ionic bonds with Asp133/Arg134 (Ni2 DRY motif) and Glu340 (Ci3) to stabilize the Gprotein coupling domain.	Hydrogen	90-98	eukaryotic translation initiation factor 3 subunit K	Homo sapiens	127-133
20532386-6	2010	Basic residues (R177, R186A, R186B, K187 and R222) interact via hydrogen bonds with the lipid headgroups to stabilize PR3 at the interfacial membrane region.	Hydrogen	64-72	proteinase 3	Homo sapiens	118-121
20493786-6	2010	Because there were strong interactions between lysozyme and monomer MAA, electrostatic interaction and hydrogen bonding, the lysozyme molecule-surface imprinting was successfully realized.	Hydrogen	103-111	lysozyme C, tracheal isozyme	Bos taurus	125-133
23037534-4	2012	Under the visible light illumination and a bias voltage below 1.2 V, the Mn-doped GaN photoelectrodes could drive the water splitting reaction for hydrogen generation.	Hydrogen	147-155	gigaxonin	Homo sapiens	82-85
23037534-5	2012	However, hydrogen generation could not be achieved under the same condition wherein undoped GaN photoelectrodes were used.	Hydrogen	9-17	gigaxonin	Homo sapiens	92-95
20572145-0	2010	S-Gal, a novel 1H MRI reporter for beta-galactosidase.	Hydrogen	15-17	galactosidase beta 1	Homo sapiens	35-53
16580821-7	2006	Phosphorylated p38 showed no changes until after 30min, peaking (284%) at 1h, followed by a small decline at 2h.	Hydrogen	74-76	mitogen activated protein kinase 14	Rattus norvegicus	15-18
22948922-6	2012	In particular, the O(eta) atom of Tyr68 in the closed lid loop forms a hydrogen bond to the side chain of a presumed catalytic residue, O(eta) of Tyr246, which acts both as an acid and a base catalyst in a syn mechanism.	Hydrogen	71-79	endothelin receptor type A	Homo sapiens	21-24
16755932-6	2006	This scFv was detected in brain tissues 1h later by capillary depletion method, which indicates that scFv protein can permeate through the blood brain barrier by mediation of the TfR receptor.	Hydrogen	40-42	transferrin receptor	Homo sapiens	179-182
20509699-4	2010	We are proposing that formation of three-center hydrogen bonds involving bifurcated peptide carbonyl acceptors (&gt;C=O) and main chains" NH, as well as side chains" -COOH proton donors is likely to underlie the observed infrared characteristics of beta(2) fibrils.	Hydrogen	48-56	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	249-255
22948922-6	2012	In particular, the O(eta) atom of Tyr68 in the closed lid loop forms a hydrogen bond to the side chain of a presumed catalytic residue, O(eta) of Tyr246, which acts both as an acid and a base catalyst in a syn mechanism.	Hydrogen	71-79	endothelin receptor type A	Homo sapiens	138-141
22702398-6	2012	Our analyses showed that hydrogen bonding of the hydroxyl group on the D ring of l-SPD with side chain of N6.55 which, in combination with hydrophobic stacking between I3.40, F6.44 and W6.48, is the key feature to mediate the agonist effect of l-SPD on D1R, whereas the absence of hydrophobic stacking between I3.40, F6.44, and W6.48 in D2R and D3R excludes receptor activation.	Hydrogen	25-33	dopamine receptor D2	Homo sapiens	337-340
20147652-4	2010	Coexpression of KLHL1 with Ca(V)3.1 or Ca(V)3.2 (alpha(1G) or alpha(1H) subunits) caused increases in T-type current density (35%) and calcium influx (75-83%) when carried out by alpha(1H) but not by alpha(1G).	Hydrogen	68-70	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	27-35
20147652-4	2010	Coexpression of KLHL1 with Ca(V)3.1 or Ca(V)3.2 (alpha(1G) or alpha(1H) subunits) caused increases in T-type current density (35%) and calcium influx (75-83%) when carried out by alpha(1H) but not by alpha(1G).	Hydrogen	185-187	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	27-35
16620117-0	2006	Oxidative addition of dihydrogen to (eta6-arene)Mo(PMe3)3 complexes: origin of the naphthalene and anthracene effects.	Hydrogen	22-32	endothelin receptor type A	Homo sapiens	37-40
16599438-7	2006	The comparison of the experimental and theoretical data suggests that in the matrixes only the non-hydrogen-bonded complex I-3 is trapped.	Hydrogen	99-107	brain protein I3	Homo sapiens	123-126
16599480-4	2006	Thermogravimetric analysis, X-ray diffraction analysis, and NMR evidence supports that heat treatment at 500 degrees C for 4 h fully dehydrates the mica, creating a hydrogen-free interlayer.	Hydrogen	165-173	MHC class I polypeptide-related sequence A	Homo sapiens	148-152
22798774-1	2012	In the title mol-ecular salt, C(3)H(8)N(+) C(7)H(4)IO(2) (-), the cyclo-propanaminium cation forms three hydrogen bonds to the 4-iodo-benzoate anion, forming two unique repeating R(4) (4)(12) hydrogen-bonding rings that result in one-dimensional hydrogen-bonded columns along the crystallographic c axis.	Hydrogen	105-113	CD1a molecule	Homo sapiens	179-183
16487484-0	2006	Quantum mechanical hydrogen tunneling in bacterial copper amine oxidase reaction.	Hydrogen	19-27	amine oxidase copper containing 3	Homo sapiens	51-71
22628195-5	2012	Powder X-ray diffraction in combination with the single crystal X-ray structure of GLY.1 clearly established the presence of a 1D hydrogen-bonded network in the xerogel of the nitrobenzene gel of GLY.1.	Hydrogen	130-138	threonine aldolase 1, pseudogene	Homo sapiens	83-88
16494969-6	2006	Docking of 2-[[-5-bromo-2-oxoindolin-3-ylidene]amino]-3-(1H-imidazol2-yl)propanoic acid 14 to CDK5/p25 indicates that this compound can interact with the enzyme through four hydrogen bonds; for GSK/3beta, the ligand poses itself in another orientation, also four hydrogen bonds can be formed between the ligand and the receptor, otherwise hydrophobic interactions seem to predominate.	Hydrogen	174-182	glycogen synthase kinase 3 beta	Homo sapiens	194-203
16494969-6	2006	Docking of 2-[[-5-bromo-2-oxoindolin-3-ylidene]amino]-3-(1H-imidazol2-yl)propanoic acid 14 to CDK5/p25 indicates that this compound can interact with the enzyme through four hydrogen bonds; for GSK/3beta, the ligand poses itself in another orientation, also four hydrogen bonds can be formed between the ligand and the receptor, otherwise hydrophobic interactions seem to predominate.	Hydrogen	263-271	glycogen synthase kinase 3 beta	Homo sapiens	194-203
20226573-3	2010	The structural requirement of chromone analogs possessing the inhibitory activity against IL-5 could be summarized as: (i) importance of hydrophobic group such as cyclohexylmethoxy at 5th position of ring A, (ii) requirement of ring B with small size of hydrogen bonding group with electron donating property such as phenolic hydroxyl group at 4th position and (iii) planarity of the chromen-4-one ring.	Hydrogen	254-262	interleukin 5	Homo sapiens	90-94
22628195-5	2012	Powder X-ray diffraction in combination with the single crystal X-ray structure of GLY.1 clearly established the presence of a 1D hydrogen-bonded network in the xerogel of the nitrobenzene gel of GLY.1.	Hydrogen	130-138	threonine aldolase 1, pseudogene	Homo sapiens	196-201
20485751-4	2010	We report defects in metabolism identified in the Schizosacchromyces pombe yeast model, where btn1, the orthologue of CLN3, has been deleted, using a metabolomics approach based on high resolution 1H and 13C NMR spectroscopy.	Hydrogen	197-199	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	94-98
22624583-9	2012	This structural feature provides rationalization for the atypical enthalpy values observed for CD2BP2-GYF because each water molecule is able to organize an extra amount of hydrogen bonds in the native state.	Hydrogen	173-181	CD2 cytoplasmic tail binding protein 2	Homo sapiens	95-101
20382163-5	2010	In the C-terminal kinase domain of MSK1, the C-terminal alphaL-helix is located in the surface groove, but forms no hydrogen bonds with the substrate-binding loop or nearby helices, and does not interfere with the protein"s autophosphorylation activity.	Hydrogen	116-124	ribosomal protein S6 kinase A5	Homo sapiens	35-39
16474894-5	2006	For the complexes CuL(0) and CuL(1) the dissociation of the amide hydrogens (CuLH(-1)) has also been detected.	Hydrogen	66-75	cullin 1	Homo sapiens	29-35
16460014-5	2006	The broadening and shifting observed in the 2D-{1H,15N}-HSQC-monitored titrations of 15N-Phe-labeled P450(eryF) with 9-AP and TST indicated binding on intermediate and fast chemical exchange time scales, respectively, which was consistent with the Hill-equation-derived K(S) values for these two ligands.	Hydrogen	48-50	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	101-111
16460027-8	2006	[1H,15N]-HSQC spectra of the talin fragment indicate that vinculin binding caused approximately two-thirds of the protein to adopt a flexible random coil.	Hydrogen	1-3	vinculin	Homo sapiens	58-66
22326626-5	2012	As for mechanisms at an atomic level that lead to a reinforcement of weak spots in more stable CS, we observe that the thermophilic CS achieve a higher thermostability by better hydrogen bonding networks whereas hyperthermophilic CS incorporate more hydrophobic contacts to reach the same goal.	Hydrogen	178-186	citrate synthase	Homo sapiens	95-97
16451034-2	2006	The first step of the H2SO4 + HO* reaction is the barrierless formation of a prereactive hydrogen-bonded complex (Cr1) lying 8.1 kcal mol(-1) below the sum of the (298 K) enthalpies of the reactants.	Hydrogen	89-97	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	114-117
16451034-3	2006	After forming Cr1, a single hydrogen transfer from H2SO4 to HO* and a degenerate double hydrogen-exchange between H2SO4 and HO* may occur.	Hydrogen	28-36	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	14-17
16451034-3	2006	After forming Cr1, a single hydrogen transfer from H2SO4 to HO* and a degenerate double hydrogen-exchange between H2SO4 and HO* may occur.	Hydrogen	88-96	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	14-17
20225050-5	2010	Because the excellent separation and retention order with Sil-CEA was maintained even in a normal-phase mobile phase such as a hexane-2-propanol, it is estimated that the CEA phase has multiple interaction mechanisms through stronger interactions such as dipole-dipole, carbonyl-pi, and hydrogen bonding interactions than the hydrophobic effect expected with ODS.	Hydrogen	287-295	STIL centriolar assembly protein	Homo sapiens	58-61
20385840-5	2010	The proton-pumping pathway of bovine CcO comprises a hydrogen-bond network and a water channel which extend to the positive and negative side surfaces, respectively.	Hydrogen	53-61	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	37-40
22326626-5	2012	As for mechanisms at an atomic level that lead to a reinforcement of weak spots in more stable CS, we observe that the thermophilic CS achieve a higher thermostability by better hydrogen bonding networks whereas hyperthermophilic CS incorporate more hydrophobic contacts to reach the same goal.	Hydrogen	178-186	citrate synthase	Homo sapiens	132-134
22326626-5	2012	As for mechanisms at an atomic level that lead to a reinforcement of weak spots in more stable CS, we observe that the thermophilic CS achieve a higher thermostability by better hydrogen bonding networks whereas hyperthermophilic CS incorporate more hydrophobic contacts to reach the same goal.	Hydrogen	178-186	citrate synthase	Homo sapiens	132-134
20206636-12	2010	Gas-phase hydrogen exchange experiments, which specifically probe the exchange of side-chain hydrogens and are carried out on shorter timescales than solution experiments, show that UmuD" incorporates more deuterium than either UmuD or UmuD3A.	Hydrogen	10-18	UmuD	Escherichia coli	182-186
20206636-12	2010	Gas-phase hydrogen exchange experiments, which specifically probe the exchange of side-chain hydrogens and are carried out on shorter timescales than solution experiments, show that UmuD" incorporates more deuterium than either UmuD or UmuD3A.	Hydrogen	93-102	UmuD	Escherichia coli	182-186
16294357-7	2006	The activation barriers and the structures of the transition states for both pathways were also calculated, and the results indicate that both pathways can be competitive and that the transition states can be described in both cases as a dihydrogen complex hydrogen-bonded to Cl- or HCl2(-).	Hydrogen	240-248	HCL2	Homo sapiens	283-287
22532294-7	2012	Concerted coordination of acetophenone and dual hydrogen-atom transfer from the PNP arm and the coordinated ethanol to, respectively, the carbonyl carbon and oxygen atoms, leads to the dearomatized complex [(iPr-PNP*)Fe(CO)(EtO)(MeCH(OH)Ph)] (32).	Hydrogen	48-56	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	224-227
16288975-4	2006	The selective iNOS inhibitor 1,3-PBIT (10 mg/kg, ip; 1h after endotoxin) prevented endotoxin-induced decrease in MAP, renal CYP 4A1/A3 protein level and CYP 4A activity and increase in systemic and renal nitrite production.	Hydrogen	53-55	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	124-127
22504965-16	2012	The drastic energy differences between the isomers of the system (H, X, E) are explained with three factors that determine the relative stabilities of the energy minima: 1) The different bond strength between the hydrogen bonds H-X and H-E. 2) The electronic excitation energy of the fragment HE from the X (2)Pi ground state to the (4)Sigma(-) excited state, which is required to establish a E X triple bond in the molecules lin-HEX.	Hydrogen	213-221	hematopoietically expressed homeobox	Homo sapiens	430-433
16405331-2	2006	The hydrogen abstraction reaction from H2 by the Cl atom is studied by means of the variational transition state theory with semiclassical tunneling coefficients on the BW2 potential energy surface.	Hydrogen	4-12	BW2	Homo sapiens	169-172
16405331-2	2006	The hydrogen abstraction reaction from H2 by the Cl atom is studied by means of the variational transition state theory with semiclassical tunneling coefficients on the BW2 potential energy surface.	Hydrogen	39-41	BW2	Homo sapiens	169-172
15981198-6	2006	The short-chain products identified allowed inference of the radical oxidation along the linoleic acid chain by abstraction of hydrogen atoms in carbon atoms ranging from C-8 to C-14.	Hydrogen	127-135	homeobox C8	Homo sapiens	171-182
20110361-4	2010	Here, we used hydrogen-deuterium exchange to determine the mechanisms of binding of glutamate and kainate (full and partial agonists, respectively) to a soluble ligand-binding domain of GluR2.	Hydrogen	14-22	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	186-191
22503861-3	2012	The calculated results reveal that the dominant interactions of C2--H2 F hydrogen bonds in [BMIM]+[PF6]- or [BMIM]+[BF4]- were not destroyed by the thiophene interactions with [BMIM]+[PF6]- and [BMIM]+[BF4]-.	Hydrogen	73-81	sperm associated antigen 17	Homo sapiens	99-102
20222664-6	2010	We find that refinement with RDCs causes significant structural corrections and yields an ensemble that is in complete agreement with the measured RDCs and presents transient mid-range inter-residue interactions between strands beta1 and beta2 of the native protein, also observed in other studies based on trans-hydrogen bond (3)J(NC") scalar couplings and paramagnetic relaxation enhancements.	Hydrogen	313-321	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	238-243
16311265-7	2006	In the HS group, this increase in neuronal mGluR5 IR was even more pronounced, but owing to neuronal loss the number of mGluR5-immunoreactive neurons was reduced compared with the non-HS group.	Hydrogen	7-9	glutamate receptor, ionotropic, kainate 1	Mus musculus	43-49
22503861-4	2012	The C--H ([BMIM]+ pi (thiophene) hydrogen bonds and H(thiophene) F([PF6]- or [BF4]- hydrogen bonds play crucial roles in the adsorption of thiophene on [BMIM]+[PF6]- and [BMIM]+[BF4]-.	Hydrogen	84-92	sperm associated antigen 17	Homo sapiens	68-71
20153225-6	2010	The pyridine nitrogen (N(AR)) of lig17 was capable of interacting with His95 (CDK4) through hydrogen bonding.	Hydrogen	92-100	cyclin dependent kinase 4	Homo sapiens	78-82
22426393-6	2012	Although no change in S-845 phosphorylation appeared in injured cultures, we observed that inhibition of NR2B-containing NMDARs significantly increased S-845 phosphorylation 1h after injury while blockade of synaptic NMDARs did not change S-845 phosphorylation at any time point following injury.	Hydrogen	174-176	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	105-109
20177374-8	2010	Furthermore, decreasing the length of the acquisition session to 1h significantly increased the difficulty of the autoshaping task further modulating the consolidation effects produced by the 5-HT2C ligands tested.	Hydrogen	65-67	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	192-198
16386654-11	2006	S100B protein blood levels were significantly higher in the LPS group at 1h (p &lt; 0.01) after LPS injection, peaking at 3h (p &lt; 0.001) and returning to baseline between 12 and 72 h. CONCLUSION: Intravenous application of endotoxin caused focal periventricular brain white matter injury, inflammation and an increase in S100B protein release.	Hydrogen	73-75	protein S100-B	Ovis aries	0-5
22612103-9	2012	Unlike previously observed jump dynamics in bulk water and other surfaces, jump events in the mica contact layer occur between hydrogen bonds formed by the water molecule and acceptor oxygens on the mica surface.	Hydrogen	127-135	MHC class I polypeptide-related sequence A	Homo sapiens	94-98
16366658-0	2005	Direct dynamics study on the hydrogen abstraction reaction CH2O + HO2 --&gt; CHO + H2O2.	Hydrogen	29-37	heme oxygenase 2	Homo sapiens	66-69
16366658-1	2005	We present a direct ab initio dynamics study on the hydrogen abstraction reaction CH2O + HO2 --&gt; CHO + H2O2, which is predicted to have four possible reaction channels caused by different attacking orientations of HO2 radical to CH2O.	Hydrogen	52-60	heme oxygenase 2	Homo sapiens	89-92
19669810-9	2010	Furthermore, two hydrogen bonds were predicted in both complexes PB1-F2/VDAC1 and PB1-F2/ANT3.	Hydrogen	17-25	voltage dependent anion channel 1	Homo sapiens	72-77
16366658-1	2005	We present a direct ab initio dynamics study on the hydrogen abstraction reaction CH2O + HO2 --&gt; CHO + H2O2, which is predicted to have four possible reaction channels caused by different attacking orientations of HO2 radical to CH2O.	Hydrogen	52-60	heme oxygenase 2	Homo sapiens	217-220
22612103-9	2012	Unlike previously observed jump dynamics in bulk water and other surfaces, jump events in the mica contact layer occur between hydrogen bonds formed by the water molecule and acceptor oxygens on the mica surface.	Hydrogen	127-135	MHC class I polypeptide-related sequence A	Homo sapiens	199-203
22425978-6	2012	Recombinant C-terminus truncated squalene synthase (WsSQS) was expressed in BL21 cells (Escherichia coli) with optimum expression induced with 1mM IPTG at 37 C after 1h.	Hydrogen	166-168	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	33-50
16354059-1	2005	[graphs: see text] QM GIAO calculations of 13C and 1H chemical shift values of the ArCH2Ar group have been performed, using the hybrid DFT functional MPW1PW91 and the 6-31G(d,p) basis set, on some representative calixarenes and on a series of simplified calixarene models allowing derivation of chemical shift surfaces versus phi and chi dihedral angles.	Hydrogen	51-53	zinc finger and BTB domain containing 8 opposite strand	Homo sapiens	83-88
19961860-6	2010	Thr189 is also identified as a crucial residue where hydrogen bonding to Asp187 keeps the latter in an optimal position for hydrogen bonding to the pyridoxal nitrogen of PLP.	Hydrogen	53-61	pyridoxal phosphatase	Homo sapiens	170-173
19961860-6	2010	Thr189 is also identified as a crucial residue where hydrogen bonding to Asp187 keeps the latter in an optimal position for hydrogen bonding to the pyridoxal nitrogen of PLP.	Hydrogen	124-132	pyridoxal phosphatase	Homo sapiens	170-173
19916574-8	2010	The backbone hydrogen bonds in HBD-1 and HNP-3 are broken during MDS.	Hydrogen	13-21	defensin alpha 3	Homo sapiens	41-46
22486151-2	2012	The resulting Pt@MOF assemblies serve as effective photocatalysts for hydrogen evolution by synergistic photoexcitation of the MOF frameworks and electron injection into the Pt nanoparticles.	Hydrogen	70-78	lysine acetyltransferase 8	Homo sapiens	17-20
16150974-0	2005	Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine.	Hydrogen	0-8	superoxide dismutase 2	Homo sapiens	26-56
16150974-6	2005	Comparison of spectra for wild-type and Y34F MnSOD showed that the phenolic hydroxyl of Tyr34 is hydrogen bonded, acting as a proton donor in the active site.	Hydrogen	97-105	superoxide dismutase 2	Homo sapiens	45-50
22486151-2	2012	The resulting Pt@MOF assemblies serve as effective photocatalysts for hydrogen evolution by synergistic photoexcitation of the MOF frameworks and electron injection into the Pt nanoparticles.	Hydrogen	70-78	lysine acetyltransferase 8	Homo sapiens	127-130
22539196-1	2012	Photo opportunity: A highly efficient and stable hybrid artificial photosynthetic H(2) evolution system is assembled by using a semiconductor (ZnS) as light-harvester and an [Fe(2)S(2)] hydrogenase mimic ([(mu-SPh-4-NH(2) )(2) Fe(2) (CO)(6)]) as catalyst for H(2) evolution.	Hydrogen	82-86	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	210-215
16262240-10	2005	Interestingly, the U39C and U39(C3) mutations shifted the equilibrium conformation of U37 into the sequestered form through formation of new hydrogen bonds in the S-turn, proximal to the essential nucleotide A38.	Hydrogen	141-149	small nucleolar RNA, C/D box 55	Homo sapiens	19-22
16262240-10	2005	Interestingly, the U39C and U39(C3) mutations shifted the equilibrium conformation of U37 into the sequestered form through formation of new hydrogen bonds in the S-turn, proximal to the essential nucleotide A38.	Hydrogen	141-149	small nucleolar RNA, C/D box 3 pseudogene 3	Homo sapiens	86-89
19782473-6	2009	administration (16 and 1h before nerve injury and then twice daily for seven days) of minocycline (30mg/kg) and pentoxifylline (20mg/kg) prevented the injury-induced changes in the levels of mGlu3 and mGlu5 receptor mRNAs and the injury-induced changes in the protein levels of all the receptors.	Hydrogen	23-25	glutamate receptor, metabotropic 3	Mus musculus	191-196
19965479-4	2009	Exp-5:RanGTP shields the pre-miRNA stem from degradation in a baseball mitt-like structure where it is held by broadly distributed weak interactions, whereas a tunnel-like structure of Exp-5 interacts strongly with the 2-nucleotide 3" overhang through hydrogen bonds and ionic interactions.	Hydrogen	252-260	exportin 5	Homo sapiens	0-5
16229838-2	2005	Herein is the first three-dimensional structure of the particle as calculated from electron microscopic images of negatively stained samples of the human ValRS/EF-1H complex.	Hydrogen	163-165	valyl-tRNA synthetase 1	Homo sapiens	154-159
22327185-4	2012	The plasma CORT levels dramatically increased 1h after stress, then returned to basal levels at 1wk, decreased 1 month later, and remained significantly lower than control levels 4 months after exposure to stress.	Hydrogen	46-48	cortistatin	Rattus norvegicus	11-15
22300432-7	2012	In the present paper we analyse the two reaction steps using the G586S mutant of nNOS (neuronal NOS), which introduces an additional hydrogen bond in the active site and provides an additional proton source.	Hydrogen	133-141	nitric oxide synthase 1	Homo sapiens	81-85
16115872-6	2005	Tyr(105) is identified as playing a key role in GTP ring opening; it is hydrogen-bonded to the zinc-activated water molecule, the latter being positioned for nucleophilic attack on the guanine C-8 atom.	Hydrogen	72-80	homeobox C8	Homo sapiens	193-196
16099164-5	2005	Ion 1+ is calculated to undergo fast migrations of protons among positions N-1, C-2, N-3, N-10, N-7, and C-8 that result in an exchange of five hydrogens before loss of a hydrogen atom forming adenine cation radical at 415 kJ mol(-1) dissociation threshold energy.	Hydrogen	144-153	homeobox C8	Homo sapiens	105-108
19865674-1	2009	Hydrogen bonded rigid imine-based macrocycles and capsules have been reduced to cyclic triamines and two-layered hexaamines, the triammonium and hexaammonium derivatives of which are revealed to form reverse vesicles in organic liquids of low polarity, which are characterized by SEM, AFM, (HR)TEM, DLS and XRD.	Hydrogen	0-8	afamin	Homo sapiens	285-288
22300432-7	2012	In the present paper we analyse the two reaction steps using the G586S mutant of nNOS (neuronal NOS), which introduces an additional hydrogen bond in the active site and provides an additional proton source.	Hydrogen	133-141	nitric oxide synthase 1	Homo sapiens	87-99
19770404-8	2009	Renal medullary COX-2 expression and urinary prostaglandin E2 excretion were significantly higher in COMT(-/-) than in wild-type mice after DOCA/HS treatment.	Hydrogen	145-147	cytochrome c oxidase II, mitochondrial	Mus musculus	16-21
19770404-9	2009	In DOCA/HS-treated COMT(-/-) mice, the COX-2 inhibitor SC-58236 reduced urinary sodium and prostaglandin E(2) excretion and increased systolic blood pressure (153+/-2 mm Hg).	Hydrogen	8-10	cytochrome c oxidase II, mitochondrial	Mus musculus	39-44
16099164-5	2005	Ion 1+ is calculated to undergo fast migrations of protons among positions N-1, C-2, N-3, N-10, N-7, and C-8 that result in an exchange of five hydrogens before loss of a hydrogen atom forming adenine cation radical at 415 kJ mol(-1) dissociation threshold energy.	Hydrogen	144-152	homeobox C8	Homo sapiens	105-108
22590012-3	2012	In the crystal, mol-ecules are linked by N-H O hydrogen bonds to generate infinite (001) sheets containing R(4) (4)(28) loops.	Hydrogen	47-55	CD1a molecule	Homo sapiens	107-111
16009714-11	2005	The additional hydrogen bonds may stabilize the complex and strengthen the binding to permit LMP1 to compete with CD40 for binding to the TRAF3 crevice, influencing downstream signaling to B lymphocytes and contributing to dysregulated signaling by LMP1.	Hydrogen	15-23	CD40 molecule	Homo sapiens	114-118
22414757-6	2012	The molecular docking analysis with PKCdelta and PKCtheta C1b subdomains revealed that the alkyl cinnamates form hydrogen bond with the backbone of the protein at the same binding site as that of diacylglycerol and phorbol esters.	Hydrogen	113-121	protein kinase C delta	Homo sapiens	36-44
16115804-7	2005	Furthermore, the solution structure of Sl moricin was determined by two-dimensional (2D) 1H-nuclear magnetic resonance (NMR) spectroscopy and hybrid distance geometry-simulated annealing calculation.	Hydrogen	89-91	moricin-2	Bombyx mori	42-49
19596825-4	2009	Intraperitoneal injection of hydrogen-rich saline before reperfusion significantly decreased plasma and myocardium malondialdehyde (MDA) concentration, decreased cardiac cell apoptosis, and myocardial 8-hydroxydeoxyguanosine (8-OHdG) in area at risk zones (AAR), suppressed the activity of caspase-3, and reduced infarct size.	Hydrogen	29-37	caspase 3	Rattus norvegicus	290-299
19615368-3	2009	Heparan sulphate proteoglycans (HSPGs) also participate in the signalling of GDNF, though binding to HS may hinder the diffusion of infused GDNF.	Hydrogen	32-34	glial cell derived neurotrophic factor	Rattus norvegicus	77-81
22241629-7	2012	A significant dose-dependent induction in reactive oxygen species (ROS) and early response markers (c-Fos, c-Jun, and GAP-43) were observed in cells exposed to 4-HNE (10, 25, and 50 microM) for 1h.	Hydrogen	194-196	growth associated protein 43	Rattus norvegicus	118-124
16002086-5	2005	Previous studies demonstrated that the regulation of Csk activity is linked to conformational changes in the enzyme that can be probed with hydrogen-deuterium exchange methods.	Hydrogen	140-148	C-terminal Src kinase	Homo sapiens	53-56
22262032-3	2012	The initial step is dominated by OH addition to the C(1)-position of Nap, forming radical C(10)H(8)-1-OH (R1), followed by the O(2) additions to the C(2) position to form peroxy radical R1-2OO, or by the hydrogen abstraction by O(2) to form 1-naphthol.	Hydrogen	204-212	ribonucleotide reductase catalytic subunit M1	Homo sapiens	106-108
15967467-4	2005	Comparison of the dynamical fluctuations of the apo and the liganded forms of the minichaperone shows that the stability (needed for SP capture) involves favorable hydrophobic interactions and hydrogen bond network formation between the SBP and WBP, and helices H and I.	Hydrogen	193-201	selenium binding protein 1	Homo sapiens	237-240
19665800-3	2009	Electrochemical data in methanol revealed that the Co(III)--&gt;Co(II) reduction of 1 (-0.84V vs. normal hydrogen electrode - NHE) is more positive than 2 (-1.13V vs. NHE), while it was expected to be more negative due to better sigma-donor ability of imidazole ring in HL1, compared to pyridine in HL2.	Hydrogen	105-113	solute carrier family 9 member C1	Homo sapiens	126-129
19665800-3	2009	Electrochemical data in methanol revealed that the Co(III)--&gt;Co(II) reduction of 1 (-0.84V vs. normal hydrogen electrode - NHE) is more positive than 2 (-1.13V vs. NHE), while it was expected to be more negative due to better sigma-donor ability of imidazole ring in HL1, compared to pyridine in HL2.	Hydrogen	105-113	solute carrier family 9 member C1	Homo sapiens	167-170
15998011-0	2005	Weak carbon-hydrogen-nitrogen interactions affect the heterocyclic ligand bonding modes in barium complexes containing eta2-tetrazolato and eta2-pentazolato ligands.	Hydrogen	12-20	DNA polymerase iota	Homo sapiens	119-123
19697903-6	2009	The halothane with the highest binding affinity at the interface between the alpha4 and beta2 subunits altered interactions between the protein and nearby lipids by competing for hydrogen bonds.	Hydrogen	179-187	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	88-93
22262032-3	2012	The initial step is dominated by OH addition to the C(1)-position of Nap, forming radical C(10)H(8)-1-OH (R1), followed by the O(2) additions to the C(2) position to form peroxy radical R1-2OO, or by the hydrogen abstraction by O(2) to form 1-naphthol.	Hydrogen	204-212	ribonucleotide reductase catalytic subunit M1	Homo sapiens	186-188
15998011-0	2005	Weak carbon-hydrogen-nitrogen interactions affect the heterocyclic ligand bonding modes in barium complexes containing eta2-tetrazolato and eta2-pentazolato ligands.	Hydrogen	12-20	DNA polymerase iota	Homo sapiens	140-144
22262032-4	2012	In the atmosphere, R1-2OO will react with NO to form R1-2O, undergo intramolecular hydrogen transfer from -OH to -OO to form R1-P2O1 radicals, or possibly undergo ring-closure to R1-29OO bi-cyclic radical; while the formation of other bi-cyclic intermediate radicals is negligible because of the extremely high Gibbs energy barriers of &gt;100 kJ mol(-1) (relative to R1+O(2)).	Hydrogen	83-91	ribonucleotide reductase catalytic subunit M1	Homo sapiens	19-21
21577607-4	2009	Inter-molecular C-H N and C-H O hydrogen bonds form C(5) chains along the a and b axes, respectively, and together they form a three-dimensional network.	Hydrogen	32-40	chimerin 1	Homo sapiens	16-29
22365600-5	2012	In addition to extensive contacts with the sugar, O-GlcNAcase recognizes the peptide backbone through hydrophobic interactions and intramolecular hydrogen bonds, while avoiding interactions with the glycopeptide side chains.	Hydrogen	146-154	O-GlcNAcase	Homo sapiens	50-61
21577608-2	2009	In the crystal, inter-molecular C-H N and C-H O hydrogen bonds generate R(3) (3)(18) ring motifs which are fused into a ribbon-like structure extending along the b axis.	Hydrogen	48-56	chimerin 1	Homo sapiens	32-45
15990730-1	2005	MALDI-TOF mass spectrometry, 1H NMR spectrometry, the continuous variation method and molecular modeling by MM3 calculation confirmed our earlier studies showing that gonadotropin-releasing hormone (GnRH) forms complex with copper(II) ion with the binding ratio 1:1.	Hydrogen	29-31	gonadotropin releasing hormone 1	Homo sapiens	167-197
15990730-1	2005	MALDI-TOF mass spectrometry, 1H NMR spectrometry, the continuous variation method and molecular modeling by MM3 calculation confirmed our earlier studies showing that gonadotropin-releasing hormone (GnRH) forms complex with copper(II) ion with the binding ratio 1:1.	Hydrogen	29-31	gonadotropin releasing hormone 1	Homo sapiens	199-203
22360206-10	2012	The TIP5P-Ewald model demonstrates an increased preference for water molecules to act both as tetrahedral hydrogen bond donors and acceptors, whereas the SWM4-NDP model demonstrates an increased preference for water molecules to act as planar hydrogen bond acceptors.	Hydrogen	243-251	norrin cystine knot growth factor NDP	Homo sapiens	159-162
15857610-5	2005	Human erythrocytes, following exposure to 50 microM BCNU for 1h at 37 degrees C, had an 84% decrease in GR activity, whereas 50 microM Cloretazine caused less than 1% inhibition under the same conditions.	Hydrogen	61-63	glutathione-disulfide reductase	Homo sapiens	104-106
19481638-4	2009	The TRPV1 antagonist pharmacophore fits within the pore region of a TRPV1 receptor homology model, with critical hydrogen bond interactions proposed between the TRPV1 antagonist pharmacophore and Tyr 667 on helix six.	Hydrogen	113-121	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
19481638-4	2009	The TRPV1 antagonist pharmacophore fits within the pore region of a TRPV1 receptor homology model, with critical hydrogen bond interactions proposed between the TRPV1 antagonist pharmacophore and Tyr 667 on helix six.	Hydrogen	113-121	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-73
19481638-4	2009	The TRPV1 antagonist pharmacophore fits within the pore region of a TRPV1 receptor homology model, with critical hydrogen bond interactions proposed between the TRPV1 antagonist pharmacophore and Tyr 667 on helix six.	Hydrogen	113-121	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-73
22347053-2	2012	An intra-molecular Se-H O hydrogen bond occurs.	Hydrogen	26-34	epoxide hydrolase 2	Homo sapiens	19-23
19581575-6	2009	Stability of the Sup35 fibril is increased by a network of hydrogen bonds involving both backbone and side chains, whereas the marginal stability of the Abeta-fibrils is largely due to the formation of weak dispersion interaction between the hydrophobic side chains.	Hydrogen	59-67	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	17-22
19581575-7	2009	The importance of the network of hydrogen bonds is further illustrated by mutational studies, which show that substitution of the Asn and Gln residues to Ala compromises the Sup35 fibril stability.	Hydrogen	33-41	translation termination factor GTPase eRF3	Saccharomyces cerevisiae S288C	174-179
18951595-6	2009	Hsp60 levels in the hearts of heat-stressed chickens gradually increased at 1h (p&lt;0.05) and peaked (p&lt;0.05) at 5h; Hsp60 levels in the liver gradually decreased at 3h (p&lt;0.05); Hsp60 levels in the kidney had no fluctuation.	Hydrogen	76-78	heat shock protein family D (Hsp60) member 1	Gallus gallus	0-5
15833342-7	2005	At high pH values, the further deprotonation of the N-H imidazole group, leading to the formation of MLH(-3), occurs, as revealed by 1H NMR spectroscopy.	Hydrogen	133-135	mutL homolog 3	Homo sapiens	101-107
15847495-0	2005	Spectrally- and time-resolved vibrational surface spectroscopy: ultrafast hydrogen-bonding dynamics at D2O/CaF2 interface.	Hydrogen	74-82	CCR4-NOT transcription complex subunit 8	Homo sapiens	107-111
22211845-0	2012	Meta-analysis: the diagnostic accuracy of lactose breath hydrogen or lactose tolerance tests for predicting the North European lactase polymorphism C/T-13910.	Hydrogen	57-65	lactase	Homo sapiens	127-134
15661660-9	2005	Exposing neuronal cultures with reduced expression of Ape1 to 65 microM H2O2 (hippocampal) or 300 microM H2O2 (sensory) for 1h results in a 3-fold and 1.5-fold increase in the phosphorylation of histone H2A.X compared to cells exposed to SCsiRNA.	Hydrogen	124-126	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	54-58
15835737-4	2005	The adsorption of human serum albumin to carboxylic and amine terminated SAMs was shown to be predominantly via non-electrostatic interactions (hydrophobic or hydrogen bonding).	Hydrogen	159-167	methionine adenosyltransferase 1A	Homo sapiens	73-77
19420658-1	2009	Mg2(Fe0.5Co0.5) elemental powder mixtures were processed by reactive ball milling in a H2 (orD2) atmosphere at about 50 bar.	Hydrogen	87-89	mucin 7, secreted	Homo sapiens	0-3
19420665-5	2009	Hydrogen readily diffuses through the Mg2Si material and nucleating MgH2 phase growth does not result in reaction completion.	Hydrogen	0-8	mucin 7, secreted	Homo sapiens	38-41
21899873-2	2012	The crystal structure of OAM reveals that His225 is within hydrogen bond distance to the PLP phenolic oxygen, and may influence the pK(a) of the Schiff base during radical rearrangement.	Hydrogen	59-67	pyridoxal phosphatase	Homo sapiens	89-92
19407415-2	2009	The planar EDTO-TTP molecules are parallel packed and exhibit strong intermolecular interactions, including side-by-side transverse S...S contacts, face-to-face longitudinal pi-pi interactions and C-H...O hydrogen bonding.	Hydrogen	205-213	ZFP36 ring finger protein	Homo sapiens	16-19
19407415-5	2009	The intermolecular interactions of the VDTO-TTP crystal are relatively weak, because of the weak pi-pi interactions and the lack of hydrogen bonding.	Hydrogen	132-140	ZFP36 ring finger protein	Homo sapiens	44-47
15689513-6	2005	Residue-specific kinetics of pH-triggered oligomerization obtained from real-time 15N-1H HSQC experiments indicate that the dimer-oligomer transition appears to involve all residues of the well-folded dimeric structure of the Ste11 SAM.	Hydrogen	86-88	mitogen-activated protein kinase kinase kinase STE11	Saccharomyces cerevisiae S288C	226-231
21899873-9	2012	From these data, we propose that His225 enhances radical stability by acting as a hydrogen bond acceptor to the phenolic oxygen, which favors the deprotonated state of the imino nitrogen and leads to greater resonance stabilization of the 2,4-diaminobutyryl-PLP radical intermediate.	Hydrogen	82-90	pyridoxal phosphatase	Homo sapiens	258-261
15599950-4	2005	In all cases but imidazole stable homocomplexes were found to form in solution, which was manifested as the presence of contact minima corresponding to hydrogen-bonded species in the PMF curves.	Hydrogen	152-160	proline rich protein BstNI subfamily 1	Homo sapiens	183-186
19136720-4	2009	Hydrogen-deuterium exchange coupled with ESI-MS was used to analyze this serpin in three forms: native, complexing, and complexed with bovine beta-trypsin.	Hydrogen	0-8	serine protease 1	Bos taurus	142-154
21957909-5	2012	Unexpectedly, the ZnF domain and the RRM form a single folding unit, glued together by extensive hydrophobic interactions and hydrogen bonds.	Hydrogen	126-134	zinc finger protein 763	Homo sapiens	18-21
19333477-0	2009	A simple template-free synthesis of nanoporous ZnS-In2S3-Ag2S solid solutions for highly efficient photocatalytic H2 evolution under visible light.	Hydrogen	114-116	angiotensin II receptor type 1	Homo sapiens	57-61
15533938-9	2005	Therefore, S(3)" and in particular the hydrogen bonding potential of Tyr(189) is a specific molecular determinant for MMP-8 triple helicase activity.	Hydrogen	39-47	helicase for meiosis 1	Homo sapiens	131-139
22197008-11	2012	Dexamethasone increased the percentage of annexin-1 positive neutrophils and mononuclear cells by 1h post treatment (from 45+-5% to 93+-1% and 62+-14% to 87+-9% for neutrophils and monocytes, respectively) but by 4h there was no difference from control cells.	Hydrogen	98-100	annexin A1	Equus caballus	42-51
15489227-8	2004	Reconstitution of mutant p65 proteins in p65-deficient fibroblasts that either mimicked phosphorylation (S536D) or preserved a predicted hydrogen bond between Ser-536 and Asp-533 (S536N) revealed that phosphorylation of Ser-536 favors interleukin-8 transcription mediated by TATA-binding protein-associated factor II31, a component of TFIID.	Hydrogen	137-145	RELA proto-oncogene, NF-kB subunit	Homo sapiens	25-28
15489227-9	2004	In the absence of phosphorylation, the hydrogen bond favors binding of the corepressor amino-terminal enhancer of split to the p65 terminal transactivation domain.	Hydrogen	39-47	RELA proto-oncogene, NF-kB subunit	Homo sapiens	127-130
15383540-10	2004	Furthermore, the crystal structure of the mutant with a restored germ line CDR2 sequence illustrates that the matured hydrophobic core of CDR1 in cAb-Lys3 might be compensated in the germ line precursor by burying solvent molecules engaged in a stable hydrogen-bonding network with CDR1 and CDR2.	Hydrogen	252-260	LOW QUALITY PROTEIN: cerebellar degeneration-related antigen 1	Camelus dromedarius	138-142
15566287-5	2004	Homology modeling and docking studies support experimental data and highlight the crucial role for the hydrogen bond between the pyridine nitrogen in position 3 of 5 and the NH-indole ring of Trp6.48, which is favorably oriented in the alpha(2C)-subtype, only.	Hydrogen	103-111	transient receptor potential cation channel subfamily C member 6	Homo sapiens	192-196
19304800-7	2009	We show using X-ray crystallography that recognition of an AGGUAA motif by a single ZnF is dominated by side-chain hydrogen bonds to the bases and formation of a guanine-tryptophan-guanine "ladder."	Hydrogen	115-123	zinc finger protein 763	Homo sapiens	84-87
19168624-8	2009	Conversely, R(*)-BIMU8 was probably the result of a direct conformational transition of Trp6.48 from inactive g+ to active t by hydrogen bonding of this residue to a carboxyl group of BIMU8.	Hydrogen	128-136	transient receptor potential cation channel subfamily C member 6	Homo sapiens	88-92
22095159-0	2012	A novel MOF with mesoporous cages for kinetic trapping of hydrogen.	Hydrogen	58-66	lysine acetyltransferase 8	Homo sapiens	8-11
19223332-8	2009	Three-dimensional models produced by restrained molecular dynamics simulations show different hydrogen-bonding patterns between the lesion and its cytosine partner and identify further stabilization of alpha-OH-PdG in a syn conformation by intra-residue hydrogen bonds.	Hydrogen	94-102	phosphoglycerate dehydrogenase	Homo sapiens	211-214
19223332-8	2009	Three-dimensional models produced by restrained molecular dynamics simulations show different hydrogen-bonding patterns between the lesion and its cytosine partner and identify further stabilization of alpha-OH-PdG in a syn conformation by intra-residue hydrogen bonds.	Hydrogen	254-262	phosphoglycerate dehydrogenase	Homo sapiens	211-214
15630560-0	2004	Estimates of methyl 13C and 1H CSA values (Deltasigma) in proteins from cross-correlated spin relaxation.	Hydrogen	28-30	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	31-34
22259432-1	2012	In the title compound, C(11)H(9)NO(4), the carboxyl group bonded to the six-membered ring lies close to the plane of the 1H-indole ring system [dihedral angle = 13.13 (9) ], whereas the carb-oxy-lic acid group linked to the five-membered ring by a methyl-ene bridge is close to perpendicular [78.85 (9) ].	Hydrogen	121-123	syntaxin 8	Homo sapiens	43-47
15515085-3	2004	For the five anions studied, the relative order of intrinsic hydrogen-bond strengths to the 1-n-butyl-3-methylimidazolium ion [X1]+ is: CF3CO2- (zero) &gt; BF4- (-3.1) &gt; PF6- (-10.0) &gt; InCl4- (-16.4) and BPh4- (-17.6 kcal mol(-1)).	Hydrogen	61-69	sperm associated antigen 17	Homo sapiens	173-176
15494440-4	2004	Mapping of the rarely found (in E. coli and yeast genomes) hydrophobicity patterns in helix 2 (H2) to known secondary structures suggests that the PrPC--&gt;PrPC* transition must be accompanied by alterations in conformations in second half of H2.	Hydrogen	95-97	prion protein	Mus musculus	147-151
15494440-4	2004	Mapping of the rarely found (in E. coli and yeast genomes) hydrophobicity patterns in helix 2 (H2) to known secondary structures suggests that the PrPC--&gt;PrPC* transition must be accompanied by alterations in conformations in second half of H2.	Hydrogen	95-97	prion protein	Mus musculus	157-161
19136213-1	2009	It is expected that the three-dimensional atom probe (3DAP) will be used as a tool to visualize the atomic scale of hydrogen atoms in steel is expected, due to its high spatial resolution and very low detection limit.	Hydrogen	116-124	death associated protein	Homo sapiens	55-58
19161338-0	2009	TbetaR-II discriminates the high- and low-affinity TGF-beta isoforms via two hydrogen-bonded ion pairs.	Hydrogen	77-85	transforming growth factor beta receptor 2	Homo sapiens	0-9
19161338-9	2009	Substitution of Arg25 and Arg94 with alanine verified the requirement of the arginine guanidinium functional groups for the highly specific hydrogen-bonded ion pairs formed between Arg25 and Arg94 of TGF-beta1 and -beta3, and Glu119 and Asp32 of TbetaR-II.	Hydrogen	140-148	transforming growth factor beta receptor 2	Homo sapiens	246-255
22099178-2	2012	Immunoblot analysis revealed early (1h) activation of the mitogen activated protein kinase (MAPK) ERK1/2, and progressive activation of epidermal growth factor receptor (EGFR), p38MAPK and p70S6 kinase (p70S6K) during 72h of isoproterenol treatment.	Hydrogen	36-38	mitogen activated protein kinase 3	Rattus norvegicus	92-96
19462659-2	2009	Complex cis-[Pt(SiMe2Cl)2(PEt3)2] (3) converts in the presence of dihydrogen into two equivalents HSiMe2Cl and complex trans-[PtH2(PEt3)2] (10).	Hydrogen	66-76	parathyroid hormone 2	Homo sapiens	126-130
15543946-0	2004	Jak2 tyrosine kinase residues glutamic acid 1024 and arginine 1113 form a hydrogen bond interaction that is essential for Jak-STAT signal transduction.	Hydrogen	74-82	Janus kinase 2	Homo sapiens	0-4
23353840-14	2012	For the CYP1B1:AAI complex, however, any hydrogen bonding of the nitro-group of AAI is prevented as Ser122/Thr124 residues are in CYP1B1 protein replaced by hydrophobic residue Ala133.	Hydrogen	41-49	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	8-14
15458623-1	2004	The crystal structures of DNA polymerase beta in complex with two different mispairs (A-C and T-C) reveal that the two bases stack partially, rather than engage in hydrogen bonding with each other (Krahn et al., this issue of Structure).	Hydrogen	164-172	DNA polymerase beta	Homo sapiens	26-45
15351820-4	2004	Furthermore, the minimised structure for the main conformer of R-4 showed that the axial hydrogens in the 3 and 5-positions with respect to the hydroxyl group prevent the enzymatic reaction.	Hydrogen	89-98	CD1a molecule	Homo sapiens	63-66
19434843-10	2009	We observed that this motion appears to be stabilized by the formation of a hydrogen bond involving serine 275 in beta-tubulin isotypes I, IIa, IIb, IVa, IVb, V, VII, and VIII.	Hydrogen	76-84	cytochrome c oxidase subunit 8A	Homo sapiens	171-175
23353840-14	2012	For the CYP1B1:AAI complex, however, any hydrogen bonding of the nitro-group of AAI is prevented as Ser122/Thr124 residues are in CYP1B1 protein replaced by hydrophobic residue Ala133.	Hydrogen	41-49	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	130-136
19191374-4	2009	The properties of the complex at its equilibrium geometry with applied field have been calculated, showing that dependencies between hydrogen bond distance, dissociation energy, and properties derived from the topological analysis of the electron distribution are analogous to those observed in families of XDH...AY complexes.	Hydrogen	133-141	xanthine dehydrogenase	Homo sapiens	307-310
23353840-18	2012	The absence of a suitable proton donor in the AAI-CYP1B1 binary complex could be the key difference, as the nitro group is in this complex surrounded only by the hydrophobic residues with potential hydrogen donors not closer than 5 A.	Hydrogen	198-206	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	50-56
22006033-0	2011	Water-catalyzed gas-phase hydrogen abstraction reactions of CH3O2 and HO2 with HO2: a computational investigation.	Hydrogen	26-34	heme oxygenase 2	Homo sapiens	70-73
18848825-7	2009	Visualisation of H2AXgamma formation demonstrated that the proportion of cells exhibiting H2AXgamma staining at 1h differed between BPDE, 40% followed by a decline, and DBPDE, &lt;10% followed by an increase.	Hydrogen	112-114	H2A.X variant histone	Homo sapiens	17-26
18848825-7	2009	Visualisation of H2AXgamma formation demonstrated that the proportion of cells exhibiting H2AXgamma staining at 1h differed between BPDE, 40% followed by a decline, and DBPDE, &lt;10% followed by an increase.	Hydrogen	112-114	H2A.X variant histone	Homo sapiens	90-99
15315402-2	2004	The structural characterization of 2 and the analogous compound LAl[OC(O)C2(SiMe3)2] (3) of the proposed intermediate A and the variable-temperature 1H NMR kinetic study of this reaction may give a better understanding on this unusual conversion.	Hydrogen	149-151	lipase A, lysosomal acid type	Homo sapiens	64-67
15291634-2	2004	Using a modulated atomic hydrogen beam, two different types of AID reaction are revealed: one is the fast AID reaction occurring only at the beam on-cycles and the other the slow AID reaction occurring even at the beam off-cycles.	Hydrogen	25-33	activation induced cytidine deaminase	Homo sapiens	63-66
22006033-0	2011	Water-catalyzed gas-phase hydrogen abstraction reactions of CH3O2 and HO2 with HO2: a computational investigation.	Hydrogen	26-34	heme oxygenase 2	Homo sapiens	79-82
15291634-2	2004	Using a modulated atomic hydrogen beam, two different types of AID reaction are revealed: one is the fast AID reaction occurring only at the beam on-cycles and the other the slow AID reaction occurring even at the beam off-cycles.	Hydrogen	25-33	activation induced cytidine deaminase	Homo sapiens	106-109
22029285-2	2011	The molecule conformational flexibility in the series is restricted by formation of the intramolecular hydrogen bond between 3-sulfo and 2-methylamino groups, which renders high potency and high selectivity to block serotonin-induced responses in HEK-293 cells stably expressing human 5-HT(6)R.	Hydrogen	103-111	5-hydroxytryptamine receptor 6	Homo sapiens	285-293
15291634-2	2004	Using a modulated atomic hydrogen beam, two different types of AID reaction are revealed: one is the fast AID reaction occurring only at the beam on-cycles and the other the slow AID reaction occurring even at the beam off-cycles.	Hydrogen	25-33	activation induced cytidine deaminase	Homo sapiens	106-109
15243185-0	2004	1H, 13C and 15N resonance assignments of the third spectrin repeat of alpha-actinin-4.	Hydrogen	0-2	actinin alpha 4	Homo sapiens	70-85
16459593-3	2004	The decomposition of cis-DCE generates the observable species H2, HCl, and ethylidyne.	Hydrogen	62-64	24-dehydrocholesterol reductase	Homo sapiens	25-28
16459593-4	2004	A fraction of cis-DCE molecules lose both chlorine atoms and add hydrogen to form ethylidyne, which is stable on the surface between 250 and 370 K. Hydrogen is liberated at about 420 K from cis-DCE surface fragments that immediately combine with surface chlorine and desorb as HCl.	Hydrogen	65-73	24-dehydrocholesterol reductase	Homo sapiens	18-21
16459593-4	2004	A fraction of cis-DCE molecules lose both chlorine atoms and add hydrogen to form ethylidyne, which is stable on the surface between 250 and 370 K. Hydrogen is liberated at about 420 K from cis-DCE surface fragments that immediately combine with surface chlorine and desorb as HCl.	Hydrogen	148-156	24-dehydrocholesterol reductase	Homo sapiens	18-21
16459593-4	2004	A fraction of cis-DCE molecules lose both chlorine atoms and add hydrogen to form ethylidyne, which is stable on the surface between 250 and 370 K. Hydrogen is liberated at about 420 K from cis-DCE surface fragments that immediately combine with surface chlorine and desorb as HCl.	Hydrogen	148-156	24-dehydrocholesterol reductase	Homo sapiens	194-197
19022217-0	2009	Relationship between beta4 hydrogen bond and beta6 hydrophobic interactions during aggregate, fiber or crystal formation in oversaturated solutions of hemoglobin A and S. Oversaturated deoxy-alpha(2)beta(2)(T4V) aggregated instantly without a delay time, which is in contrast to the delay time before the generation of fibers of deoxy-HbS and deoxy-alpha(2)beta(2)(E6V,D73H).	Hydrogen	27-35	tubulin beta 3 class III	Homo sapiens	21-26
19022217-2	2009	These results indicate that beta4Val in HbA in the oxy and deoxy forms with or without beta6Val facilitates hydrophobic interaction of the A-helix with the EF helix of adjacent molecules without forming a beta4/beta73 hydrogen bond.	Hydrogen	218-226	tubulin beta 3 class III	Homo sapiens	28-33
19153467-8	2009	The structures show that the peptides interact with cIAP1 in the same way that they interact with XIAP: both peptides bind in a similar shallow groove in the BIR3 surface, anchored at the N-terminus by a charge-stabilized hydrogen bond.	Hydrogen	222-230	baculoviral IAP repeat containing 2	Homo sapiens	52-57
15240449-8	2004	Between the interfaces in the ScyTx-rsk2 complex, strong electrostatic interaction and hydrogen bonds exist between Arg(13) of ScyTx and Gly-Tyr-Gly-Asp sequential residues located in the four symmetrical chains of the pore region.	Hydrogen	87-95	ribosomal protein S6 kinase A3	Homo sapiens	36-40
22199711-3	2011	The crystal structure features inter-molecular C-H N and C-H O non-classical hydrogen bonds, building an infinite one-dimensional network along the [100] direction.	Hydrogen	77-85	chimerin 1	Homo sapiens	47-60
15158402-1	2004	H2 generation during mechanochemical treatment of kaolinite by dry grinding was examined by X-ray diffraction analysis, Fourier transform infrared spectroscopy, and BET surface area measurement.	Hydrogen	0-2	delta/notch like EGF repeat containing	Homo sapiens	165-168
21563215-8	2011	The sequences and conformations are improved with respect to our previous, polar-hydrogen/CASA study: For several designed complexes, the AspAMP carboxylate forms three interactions with a conserved arginine and a designed lysine, as in the active site of the AspRS:AspAMP complex.	Hydrogen	81-89	aspartyl-tRNA synthetase 1	Homo sapiens	260-265
15339210-1	2004	Effects of solvent, pH and hydrogen bonding with N-methylimidazole (MIm) on the photophysical properties of 1-hydroxyfluorenone (1HOF) have been studied.	Hydrogen	27-35	MTSS I-BAR domain containing 1	Homo sapiens	68-71
15339210-6	2004	On addition of MIm in toluene, dual fluorescence was observed, which was attributed to reversible formation of excited hydrogen-bonded ion pair.	Hydrogen	119-127	MTSS I-BAR domain containing 1	Homo sapiens	15-18
19650097-0	2009	PST-1: a synthetic small-pore zeolite that selectively adsorbs H2.	Hydrogen	63-65	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	0-5
18996093-2	2008	We have found that hydrogen (dihydrogen; H(2)) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K. Katsura, Y. Katayama, S, Asoh, S. Ohta, Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, Nat.	Hydrogen	19-27	bromodomain containing 2	Mus musculus	323-326
21910150-9	2011	Hydrogen-deuterium exchange experiments showed decreased stability around the CDR3 grafting region of Ubi-(1RI8), which might explain the decreased antigen-binding ability and the differences in thermodynamic properties.	Hydrogen	0-8	CDR3	Homo sapiens	78-82
19088188-5	2008	The crystal structures of the SET8 Y334F mutant bound to histone H4 peptides bearing unmodified, monomethyl, and dimethyl Lys-20 reveal that the phenylalanine substitution attenuates hydrogen bonding to a structurally conserved water molecule adjacent to the Phe/Tyr switch, facilitating its dissociation.	Hydrogen	183-191	lysine methyltransferase 5A	Homo sapiens	30-34
15174865-2	2004	The beta N-O turns and beta N-O helices that involve a nine-membered-ring intramolecular hydrogen bond between NH(i)(+2) and CO(i), which have been found previously in peptides of beta(2,2)-aminoxy acids (NH(2)OCH(2)CMe(2)COOH), are also present in those beta(3)-aminoxy peptides.	Hydrogen	89-97	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	180-188
22241307-5	2011	RESULTS: MC3T3-E1 cells were stimulated with 10mug/mL P.e-LPS for 1h,the expression of CD14 and TLR4 mRNA increased significantly.	Hydrogen	66-68	MARCKS-like 1	Mus musculus	51-55
18950098-4	2004	Incorporation of K[(C2H4)PtCl3].H2O (a Zeise salt) into the PODS/ODC matrix, followed by reduction of the Pt ions by NaBH4 or H2, results in the localization of Pt compounds and nanoparticles along the siloxy bilayers, which remain dimensionally unchanged.	Hydrogen	32-34	ornithine decarboxylase 1	Homo sapiens	60-68
15252636-3	2004	Complex 1 shows dynamic NMR behaviour in both the 31P and 1H NMR spectra with facile exchange between the protons in the eta2-dihydrogen ligand and the eta1-hydrido ligand.	Hydrogen	58-60	DNA polymerase iota	Homo sapiens	121-125
18998622-9	2008	The other two, 2(PF(6)) and 8(PF(6)), form networks linked through amide-anion N-H...F hydrogen bonds.	Hydrogen	87-95	sperm associated antigen 17	Homo sapiens	17-22
18998622-9	2008	The other two, 2(PF(6)) and 8(PF(6)), form networks linked through amide-anion N-H...F hydrogen bonds.	Hydrogen	87-95	sperm associated antigen 17	Homo sapiens	30-35
21981450-8	2011	The agreement between macroscopic observables and molecular simulations confirms the role of water-shielded hydrogen bonds as kinetic traps and illustrates how our finding could be used as an aid in structure-based drug discovery.	Hydrogen	108-116	activation induced cytidine deaminase	Homo sapiens	192-195
18989928-1	2008	Short homo-oligomers of a new building block, cis-beta(2,3)-furanoid sugar aminoxy acid, are designed, characterized, and found to exhibit rigid ribbon-like secondary structures composed of 5/7 bifurcated intramolecular hydrogen bonds.	Hydrogen	220-228	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	50-58
15115407-1	2004	New 1H,3H-pyrimido[2,1-f]purine-2,4-dione derivatives of arylpiperazine (11-22) were prepared and evaluated in vitro for their affinity for 5-HT(1A), 5-HT(2A), alpha(1), and D(2) receptors.	Hydrogen	4-6	5-hydroxytryptamine receptor 1A	Rattus norvegicus	140-147
22007669-2	2011	LS(AN) is generated by addition of coordinating base to the parent complex {[(F8)Fe]-O2-[Cu(AN)]}+ (HS(AN)) in which the O2(2-) bridges the metals in an mu-eta2:eta2 or "side-on" mode.	Hydrogen	100-102	DNA polymerase iota	Homo sapiens	156-160
22007669-2	2011	LS(AN) is generated by addition of coordinating base to the parent complex {[(F8)Fe]-O2-[Cu(AN)]}+ (HS(AN)) in which the O2(2-) bridges the metals in an mu-eta2:eta2 or "side-on" mode.	Hydrogen	100-102	DNA polymerase iota	Homo sapiens	161-165
15078099-7	2004	Namely, after hydrogen abstraction of the C-23 position of 1alpha,25(OH)(2)D(3), part of the substrate-radical intermediate is converted into 25,26,27-trinor-23-ene-1alpha(OH)D(3), while a major part of them is converted into 1alpha,23,25(OH)(3)D(3).	Hydrogen	14-22	nucleolin	Homo sapiens	42-46
22049338-6	2011	Complex formation with ERRgamma induces significant changes in the conformational mobility of both partners, highlighted by significant stabilization of the ligand binding domain (ERRgammaLBD) as determined by HDX (hydrogen/deuterium exchange) and an observed disorder-to-order transition in PGC-1alpha(2-220).	Hydrogen	215-223	estrogen related receptor gamma	Homo sapiens	23-31
14979715-8	2004	The cofactor binds deeply in the cavity and has extensive interactions with PGFS through hydrogen bonds, whereas the substrate (PGD(2)) is located above the bound cofactor and has little interaction with PGFS.	Hydrogen	89-97	aldo-keto reductase family 1 member C3	Homo sapiens	76-80
14979715-9	2004	Despite being largely structurally different from PGD(2), rutin is located at the same site of PGD(2), and its catechol and rhamnose moieties are involved in hydrogen bonds with PGFS.	Hydrogen	158-166	aldo-keto reductase family 1 member C3	Homo sapiens	178-182
22219897-4	2011	The crystal structure is stabilized by weak inter-molecular C-H N and C-H O hydrogen bonds.	Hydrogen	76-84	chimerin 1	Homo sapiens	60-73
21703367-1	2011	In this contribution we review recent NMR studies of protonation and hydrogen bond states of pyridoxal 5"-phosphate (PLP) and PLP model Schiff bases in different environments, starting from aqueous solution, the organic solid state to polar organic solution and finally to enzyme environments.	Hydrogen	69-77	pyridoxal phosphatase	Homo sapiens	117-120
21703367-1	2011	In this contribution we review recent NMR studies of protonation and hydrogen bond states of pyridoxal 5"-phosphate (PLP) and PLP model Schiff bases in different environments, starting from aqueous solution, the organic solid state to polar organic solution and finally to enzyme environments.	Hydrogen	69-77	pyridoxal phosphatase	Homo sapiens	126-129
21703367-3	2011	It is shown that protonation of the pyridine ring of PLP in aspartate aminotransferase (AspAT) is achieved by (i) an intermolecular OHN hydrogen bond with an aspartate residue, assisted by the imidazole group of a histidine side chain and (ii) a local polarity as found for related model systems in a polar organic solvent exhibiting a dielectric constant of about 30.	Hydrogen	136-144	pyridoxal phosphatase	Homo sapiens	53-56
22004969-4	2011	From molecular docking, hydrogen-bonding and hydrophobic interactions were observed to be characteristic interactions between compounds and AhR.	Hydrogen	24-32	aryl hydrocarbon receptor	Homo sapiens	140-143
15214415-4	2004	The ab-initio gas phase structures of [BMIM][PF6] indicate that the 1-butyl-3-methylimidazolium C2 hydrogen, the ring methyl group, and the butyl side-chain hydrogen atoms form hydrogen bonds with the hexafluorophosphate anion.	Hydrogen	99-107	sperm associated antigen 17	Homo sapiens	45-48
15214415-4	2004	The ab-initio gas phase structures of [BMIM][PF6] indicate that the 1-butyl-3-methylimidazolium C2 hydrogen, the ring methyl group, and the butyl side-chain hydrogen atoms form hydrogen bonds with the hexafluorophosphate anion.	Hydrogen	157-165	sperm associated antigen 17	Homo sapiens	45-48
15214415-4	2004	The ab-initio gas phase structures of [BMIM][PF6] indicate that the 1-butyl-3-methylimidazolium C2 hydrogen, the ring methyl group, and the butyl side-chain hydrogen atoms form hydrogen bonds with the hexafluorophosphate anion.	Hydrogen	157-165	sperm associated antigen 17	Homo sapiens	45-48
14752262-0	2004	1H, 15N and 13C NMR resonance assignments of staphostatin A, a specific Staphylococcus aureus cysteine proteinase inhibitor.	Hydrogen	0-2	AT695_RS07660	Staphylococcus aureus	45-59
14960371-3	2004	Side-chain conformations of residues within the NR1 ligand-binding site were selected that optimized the hydrophobic packing and hydrogen bonding among residues, while taking into account published data comparing receptor mutants with wild-type NR1.	Hydrogen	129-137	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	48-51
14638684-1	2004	The side chains of His30 and Tyr166 from adjacent subunits in the homotetramer human manganese superoxide dismutase (Mn-SOD) form a hydrogen bond across the dimer interface and participate in a hydrogen-bonded network that extends to the active site.	Hydrogen	132-140	superoxide dismutase 2	Homo sapiens	85-115
14638684-1	2004	The side chains of His30 and Tyr166 from adjacent subunits in the homotetramer human manganese superoxide dismutase (Mn-SOD) form a hydrogen bond across the dimer interface and participate in a hydrogen-bonded network that extends to the active site.	Hydrogen	132-140	superoxide dismutase 2	Homo sapiens	117-123
18948593-3	2008	Here, we report the architecture of the complex between the yeast Hsp110, Sse1, and its cognate Hsp70 partner, Ssa1, as revealed by hydrogen-deuterium exchange analysis and site-specific cross-linking.	Hydrogen	132-140	adenyl-nucleotide exchange factor SSE1	Saccharomyces cerevisiae S288C	74-78
18706888-2	2008	To clarify the mechanism of hydrogen"s effect in the brain, we administered hydrogen-rich pure water (H(2)) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant.	Hydrogen	76-84	regucalcin	Mus musculus	148-189
18706888-2	2008	To clarify the mechanism of hydrogen"s effect in the brain, we administered hydrogen-rich pure water (H(2)) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant.	Hydrogen	102-106	regucalcin	Mus musculus	148-189
18635159-7	2008	The large deconvoluted band at 3340cm(-1) referred to strong interchain hydrogen bonds involving the hydroxyl groups at C-6.	Hydrogen	72-80	complement C6	Homo sapiens	120-123
18635159-8	2008	The crystallinity of 54% calculated from the WAXD supports also the dependency of the usually observed crystallization in cellulose of the hydroxyl groups at C-6 to engage in interchain hydrogen bonding.	Hydrogen	186-194	complement C6	Homo sapiens	158-161
18054273-0	2008	The subtle electronic effects of alkyl groups on the conformational equilibria and intramolecular hydrogen-bond strength in cis-3-alkoxycyclohexanols.	Hydrogen	98-106	suppressor of cytokine signaling 3	Homo sapiens	124-129
18808674-5	2008	Circular dichroism spectra at different temperatures up to 70 degrees C showed that Tat Eli is not a random coil at 20 degrees C. Homonuclear 1H NMR spectra allowed us to identify 1639 NMR distance constraints out of which 264 were interresidual.	Hydrogen	142-144	tyrosine aminotransferase	Homo sapiens	84-87
14638684-1	2004	The side chains of His30 and Tyr166 from adjacent subunits in the homotetramer human manganese superoxide dismutase (Mn-SOD) form a hydrogen bond across the dimer interface and participate in a hydrogen-bonded network that extends to the active site.	Hydrogen	194-202	superoxide dismutase 2	Homo sapiens	85-115
14638684-1	2004	The side chains of His30 and Tyr166 from adjacent subunits in the homotetramer human manganese superoxide dismutase (Mn-SOD) form a hydrogen bond across the dimer interface and participate in a hydrogen-bonded network that extends to the active site.	Hydrogen	194-202	superoxide dismutase 2	Homo sapiens	117-123
21795584-7	2011	Molecular docking revealed strong interaction of the ligand with the p65 via two hydrogen bonds one with Lys(37) (2.204 A) and another with Cys(38) (2.023 A).	Hydrogen	81-89	RELA proto-oncogene, NF-kB subunit	Homo sapiens	69-72
14763746-2	2004	This stationary phase, when used in conjunction with a 2 mM ethylenediamine and 0.1 mM Li-DS solution as eluent at pH 6.0, was found to be suitable for the rapid and efficient separation of hydrogen and magnesium and calcium in the order H+ &lt; Mg2+ &lt; Ca2+ within 4 min at a flow rate of 4.0 ml/min.	Hydrogen	190-198	mucin 7, secreted	Homo sapiens	246-249
14756555-10	2004	The structure shows that Tyr-226 donates a hydrogen bond to the phosphate of PLP.	Hydrogen	43-51	pyridoxal phosphatase	Homo sapiens	77-80
14756555-11	2004	Unusual among PLP-dependent enzymes, Trp-256, which is also strictly conserved in kynureninases from bacteria to humans, donates a hydrogen bond to the phosphate through the indole N1-hydrogen.	Hydrogen	131-139	pyridoxal phosphatase	Homo sapiens	14-17
14756555-11	2004	Unusual among PLP-dependent enzymes, Trp-256, which is also strictly conserved in kynureninases from bacteria to humans, donates a hydrogen bond to the phosphate through the indole N1-hydrogen.	Hydrogen	184-192	pyridoxal phosphatase	Homo sapiens	14-17
18590744-4	2008	Molecular dynamics simulations for unbound CCR5 showed hydrogen bond interactions among transmembrane residues Y108, E283, and Y251, which were crucial for HIV-1-gp120/sCD4 complex binding and HIV-1 fusion.	Hydrogen	55-63	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	162-167
18729332-5	2008	This is due to partitioning of the benzylic free radial intermediate between oxygen rebound to form 12-OH-NVP and loss of another hydrogen atom to form a reactive quinone methide, which inactivates P450.	Hydrogen	130-138	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	198-202
14756559-4	2004	(i) The structure of T44D-Ang indicates that Asp44 can participate directly in pyrimidine binding and that the intrinsic hydrogen-bonding capability of this residue largely governs the pyrimidine specificity of this variant.	Hydrogen	121-129	angiogenin	Homo sapiens	26-29
21984209-5	2011	The C-terminal domain of DKK1 (DKK1c) interacts with the top surface of the LRP6-E3 YWTD propeller and given their structural similarity, probably also that of the LRP6-E1 propeller, through conserved hydrophobic patches buttressed by a network of salt bridges and hydrogen bonds.	Hydrogen	265-273	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	25-29
14756559-7	2004	(ii) The structure of T80A-Ang supports the view that Thr80 plays little role in maintaining the obstructive conformation of the C-terminus and that its participation in a hydrogen bond with Thr44 selectively weakens the interaction between Thr44 and N3 of cytosine.	Hydrogen	172-180	angiogenin	Homo sapiens	27-30
14729343-8	2004	Together, these data build up a picture of how the IAPP fibril is held together by hydrogen bonded beta-sheet structure and contribute to the understanding of the generic structure of amyloid fibrils.	Hydrogen	83-91	islet amyloid polypeptide	Homo sapiens	51-55
18664402-5	2008	EXAFS and infrared spectroscopic measurements on pure water have shown previously that the ratios of ortho and para isomers of the hydrogen atoms of water occur on a similar time scale and produce regular patterns of unequally spaced oscillations similar to those observed with ECTO-NOX proteins and Cu(II)Cl(2) solutions.	Hydrogen	131-139	tripartite motif containing 33	Homo sapiens	278-282
21984209-5	2011	The C-terminal domain of DKK1 (DKK1c) interacts with the top surface of the LRP6-E3 YWTD propeller and given their structural similarity, probably also that of the LRP6-E1 propeller, through conserved hydrophobic patches buttressed by a network of salt bridges and hydrogen bonds.	Hydrogen	265-273	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	31-36
21830828-10	2011	The current results demonstrate that fluorine makes a hydrogen bond of intermediate strength through cooperative interaction of another hydrogen bond (C-H   N) present in the dimer, although fluorine is believed to be very weak hydrogen bond acceptor.	Hydrogen	54-62	chimerin 1	Homo sapiens	151-158
18603371-6	2008	H2 treatment in a duration-dependent manner significantly reduced the number of positive TUNEL cells and suppressed caspase-3 and -12 activities.	Hydrogen	0-2	caspase 3	Rattus norvegicus	116-133
14534297-7	2004	The suppressor mutation N268D results in an altered hydrogen bond pattern connecting strands S1 and S10, thus bridging the two sheets of the beta-sandwich scaffold in an energetically more favorable way.	Hydrogen	52-60	ribosomal protein S10	Homo sapiens	100-103
21830828-10	2011	The current results demonstrate that fluorine makes a hydrogen bond of intermediate strength through cooperative interaction of another hydrogen bond (C-H   N) present in the dimer, although fluorine is believed to be very weak hydrogen bond acceptor.	Hydrogen	136-144	chimerin 1	Homo sapiens	151-158
14727916-2	2004	The planar catechin (P1H(2)), in which the catechol and chroman structure in (+)-catechin (1H(2)) are constrained to be planar, undergoes efficient hydrogen atom transfer toward galvinoxyol radical, showing an enhanced protective effect against the oxidative DNA damage induced by the Fenton reaction.	Hydrogen	148-156	minichromosome maintenance complex component 3	Homo sapiens	21-24
14727916-4	2004	The kinetics of hydrogen transfer from catechins to cumylperoxyl radical has been examined in propionitrile at low temperature with use of ESR, showing that the rate of hydrogen transfer from P1H(2) is significantly faster than that from 1H(2).	Hydrogen	16-24	minichromosome maintenance complex component 3	Homo sapiens	192-195
21830828-10	2011	The current results demonstrate that fluorine makes a hydrogen bond of intermediate strength through cooperative interaction of another hydrogen bond (C-H   N) present in the dimer, although fluorine is believed to be very weak hydrogen bond acceptor.	Hydrogen	136-144	chimerin 1	Homo sapiens	151-158
14727916-4	2004	The kinetics of hydrogen transfer from catechins to cumylperoxyl radical has been examined in propionitrile at low temperature with use of ESR, showing that the rate of hydrogen transfer from P1H(2) is significantly faster than that from 1H(2).	Hydrogen	169-177	minichromosome maintenance complex component 3	Homo sapiens	192-195
14727916-6	2004	Such an acceleration effect of metal ion indicates that the hydrogen transfer reaction proceeds via metal ion-promoted electron transfer from P1H(2) to oxyl radical followed by proton transfer rather than via a one-step hydrogen atom transfer.	Hydrogen	60-68	minichromosome maintenance complex component 3	Homo sapiens	142-145
18467331-3	2008	The binding of PRL variants to the PRLR extracellular domain was furthermore characterized by the solution state techniques, hydrogen exchange mass spectrometry, and NMR spectroscopy.	Hydrogen	125-133	prolactin receptor	Homo sapiens	35-39
21546247-1	2011	A mutant plant (Arabidopsis thaliana), sex1-1 (starch excess 1-1), accumulating high starch content in leaves was created to serve as better biomass feedstock for a H2-producing strain Clostridium butyricum CGS2, which efficiently utilizes starch for H2 production but cannot assimilate cellulosic materials.	Hydrogen	165-167	Pyruvate phosphate dikinase, PEP/pyruvate binding domain-containing protein	Arabidopsis thaliana	39-45
18467119-1	2008	Gas-phase hydrogen/deuterium exchange of small oligonucleotides (dTG, dC(6) and C(6)) with CD(3)OD was performed in the second hexapole of a Fourier transform ion-cyclotron resonance (FTICR) mass spectrometer.	Hydrogen	10-18	complement C6	Homo sapiens	71-75
14727916-6	2004	Such an acceleration effect of metal ion indicates that the hydrogen transfer reaction proceeds via metal ion-promoted electron transfer from P1H(2) to oxyl radical followed by proton transfer rather than via a one-step hydrogen atom transfer.	Hydrogen	220-228	minichromosome maintenance complex component 3	Homo sapiens	142-145
14727916-7	2004	The electrochemical ease of P1H(2) for the one-electron oxidation investigated by second-harmonic alternating current voltammetry strongly supports the two step mechanism for hydrogen transfer, resulting in the enhanced radical scavenging ability.	Hydrogen	175-183	minichromosome maintenance complex component 3	Homo sapiens	28-31
17150500-4	2004	The 1H-15N HSQC spectra of the IRF-4/DNA complex containing the CCGAAA sequence indicated that the 1:1 complex was formed.	Hydrogen	4-6	interferon regulatory factor 4	Homo sapiens	31-36
18420387-9	2008	As a consequence the azide forms an H bond with Gln143 instead with Tyf34, in contrast to non-(19)F-labeled MnSOD, where the azide is hydrogen bonded to the hydroxy group of Tyr34.	Hydrogen	134-142	superoxide dismutase 2	Homo sapiens	108-113
21546247-3	2011	Using sex1-1 mutant plant as feedstock, C. butyricum CGS2 could produce 490.4 ml/l of H2 with a H2 production rate of 32.9 ml/h/l.	Hydrogen	86-88	Pyruvate phosphate dikinase, PEP/pyruvate binding domain-containing protein	Arabidopsis thaliana	6-12
21546247-3	2011	Using sex1-1 mutant plant as feedstock, C. butyricum CGS2 could produce 490.4 ml/l of H2 with a H2 production rate of 32.9 ml/h/l.	Hydrogen	96-98	Pyruvate phosphate dikinase, PEP/pyruvate binding domain-containing protein	Arabidopsis thaliana	6-12
14663341-4	2003	Thus, the purpose of this study was to evaluate the method of CBF measurements using a beta-probe and H2 15O.	Hydrogen	102-104	CCAAT/enhancer binding protein zeta	Rattus norvegicus	62-65
21661078-2	2011	The crystal structure revealed that the Pro47-Ser65 moiety of 4E-BP2 adopts a L-shaped conformation involving extended and alpha-helical structures and extends over the N-terminal loop and two different helix regions of eIF4E through hydrogen bonds, and electrostatic and hydrophobic interactions; these features were similarly observed for 4E-BP1.	Hydrogen	234-242	eukaryotic translation initiation factor 4E	Homo sapiens	220-225
14645682-7	2003	The changes of binding energy between transporter proteins and different uridine analogs suggested that hCNT1 formed hydrogen bonds (H-bonds) with C(3")-OH, C(5")-OH, or N(3)-H of uridine, but not with C(2")-OH, whereas hCNT3 formed H-bonds to C(3")-OH, but not to N(3)-H, C(5")-OH, and C(2")-OH.	Hydrogen	117-125	solute carrier family 28 member 3	Homo sapiens	220-225
21828666-4	2008	Hydrogen sensors made from the SnO(2) nanoparticles were found to possess high sensitivity and stability.	Hydrogen	0-8	strawberry notch homolog 1	Homo sapiens	31-34
21699926-7	2011	An apoptosis assay showed that the number of apoptotic cells was significantly decreased in GDNF-pretreated NSCs at 1h and 6h after OGD.	Hydrogen	116-118	glial cell derived neurotrophic factor	Rattus norvegicus	92-96
21202782-3	2008	The PF(6) (-) anion links the cobaltocenium cations via weak C-H F hydrogen bonds into a chain running along the b axis.	Hydrogen	67-75	sperm associated antigen 17	Homo sapiens	4-9
14627829-3	2003	We systematically derived a hydrogen bond model for the complementarity between the free 5" end of U1 snRNA and 5" splice sites and numerous mutations following transient transfection of HeLa-T4+ cells with 5" splice site mutated vectors.	Hydrogen	28-36	RNA, U1 small nuclear 1	Homo sapiens	99-113
21813965-1	2011	Using first-principles calculations we have studied the electronic and structural properties of cation vacancies and their complexes with hydrogen impurities in SnO(2), In(2)O(3) and beta-Ga(2)O(3).	Hydrogen	138-146	strawberry notch homolog 1	Homo sapiens	161-164
12954649-5	2003	In addition, Asp-634 within the Shank1 PDZ domain recognizes the positively charged Arg at -1 position and hydrogen bonds, and salt bridges between Arg-607 and the side chains of the ligand at -3 and -5 positions contribute further to the recognition of the peptide ligand.	Hydrogen	107-115	SH3 and multiple ankyrin repeat domains 1	Homo sapiens	32-38
18093734-3	2008	An acetic-type microbial metabolism was established with sulfate-reducing bacteria (SRB) significantly consuming hydrogen and volatile fatty acids produced by acidogenic bacteria and hydrogen producing acetogens in degrading COD, thereby yielding sulfate removal rate&gt;94.6%.	Hydrogen	113-121	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	225-228
22091022-2	2011	In the crystal, inter-molecular N-H S, C-H S and C-H O hydrogen bonds link the mol-ecules, forming a two-dimensional network parallel to (101).	Hydrogen	55-63	lysosomal trafficking regulator	Homo sapiens	39-52
19636912-0	2008	Backbone and sidechain 1H, 13C and 15N resonance assignments of the Bright/ARID domain from the human JARID1C (SMCX) protein.	Hydrogen	23-25	lysine demethylase 5C	Homo sapiens	102-109
19636912-0	2008	Backbone and sidechain 1H, 13C and 15N resonance assignments of the Bright/ARID domain from the human JARID1C (SMCX) protein.	Hydrogen	23-25	lysine demethylase 5C	Homo sapiens	111-115
19636912-1	2008	We have assigned 1H, 13C and 15N resonances of the Bright/ARID DNA-binding domain from the human JARID1C protein, a newly discovered histone demethylase belonging to the JmjC domain-containing protein family.	Hydrogen	17-19	lysine demethylase 5C	Homo sapiens	97-104
19636915-0	2008	1H, 13C and 15N resonance assignments for the human E2 conjugating enzyme, UbcH7.	Hydrogen	0-2	ubiquitin conjugating enzyme E2 L3	Homo sapiens	75-80
19636924-0	2008	1H, 13C, and 15N chemical shift assignments for the Eps15-EH2-stonin 2 complex.	Hydrogen	0-2	stonin 2	Homo sapiens	62-70
15072432-11	2003	The preference of conformer VIII in the protonated forms is explained by the higher strength of its intramolecular hydrogen bond over the cation-pi interaction found in conformer I.	Hydrogen	115-123	cytochrome c oxidase subunit 8A	Homo sapiens	28-32
14572630-4	2003	The secondary structure in the C-terminal domain of EPR is different from other EGF-family ligands because of the lack of hydrogen bonds.	Hydrogen	122-130	epiregulin	Homo sapiens	52-55
19636925-0	2008	1H, 13C and 15N resonance assignment of Urm1 from Trypanosoma brucei.	Hydrogen	0-2	ubiquitin-related modifier URM1	Saccharomyces cerevisiae S288C	40-44
22091042-2	2011	In the crystal, two structurally independent formula units are linked via N-H S hydrogen bonds, forming an inversion dimer, with graph-set motif R(4) (4)(12).	Hydrogen	80-88	CD1a molecule	Homo sapiens	145-149
19636928-0	2008	Backbone 1H, 13C, and 15N NMR assignments of the tail domain of vinculin.	Hydrogen	9-11	vinculin	Homo sapiens	64-72
22091181-3	2011	The title structure represents an example of a sulfonate anion that is part of a hydrogen-bonding R(4) (4)(12) graph-set motif, which is well known for related dipH acetates.	Hydrogen	81-89	CD1a molecule	Homo sapiens	98-102
19636928-2	2008	Here we report the majority of the backbone 1H(N), 15N, 13C(alpha), 13CO, and side chain 13C(beta) NMR resonance assignments of the actin binding tail domain of vinculin (Vt).	Hydrogen	44-46	vinculin	Homo sapiens	161-169
21627113-1	2011	Hydrogen-end-capped polyynes, H(C C)(n)H (n = 5-7), were photoirradiated in the presence of iodine molecules in nonpolar solvents to find a dramatic change in the UV/vis absorption spectrum.	Hydrogen	0-8	HCC	Homo sapiens	30-35
14516195-8	2003	The side chains of Pca1 and Lys9 form a hydrogen bond in crystalline ONC.	Hydrogen	40-48	prostate cancer associated transcript 1	Homo sapiens	19-23
14516195-11	2003	The thermodynamic cycle derived from k(cat)/K(M) values indicates that the Pca1...Lys9 hydrogen bond contributes 2.0 kcal/mol to the stabilization of the rate-limiting transition state during catalysis.	Hydrogen	87-95	prostate cancer associated transcript 1	Homo sapiens	75-79
18172837-10	2008	For the "mixed" (hydrogen bonded and dispersive) interactions in the S22 subset, results obtained with the BHandHLYP and PS-LMP2 calculations agreed well with the reference calculations.	Hydrogen	17-25	proteasome 20S subunit beta 9	Homo sapiens	124-128
21565256-0	2011	Hydrogen [corrected] peroxide-dependent photocytotoxicity by phloxine B, a xanthene-type food colorant.	Hydrogen	0-8	prohibitin 1	Homo sapiens	61-71
18443424-5	2008	Based on structural and biochemical information about RANKL and the OPG peptides, we suggest that complex formation between the peptide and RANKL is mediated by both hydrophobic and hydrogen bonding interactions.	Hydrogen	182-190	TNF receptor superfamily member 11b	Homo sapiens	68-71
14587735-0	2003	Model systems for flavoenzyme activity: flavin-functionalised SAMs as models for probing redox modulation through hydrogen bonding.	Hydrogen	114-122	methionine adenosyltransferase 1A	Homo sapiens	62-66
12927869-9	2003	Results show that analogues with 4"-substituents that are small, polar and with hydrogen bonding capacities are most potent ALDH-2 inhibitors, whereas those that are non-polar and with electron withdrawing capacities are potent MAO inhibitors.	Hydrogen	80-88	aldehyde dehydrogenase 2 family member	Homo sapiens	124-130
20649465-2	2011	Previous studies demonstrated that XPC protein operates by detecting the single-stranded character of non-hydrogen-bonded bases opposing lesion sites.	Hydrogen	106-114	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	35-38
12895058-7	2003	The structure of the cyclic Gaa dimer 8b displayed an unusual six-membered intramolecular hydrogen bond between NH(i)() --&gt; C3-O(i)()(-)(1) and a syn orientation between the C2-H and CO.	Hydrogen	90-98	alpha glucosidase	Homo sapiens	28-31
18452327-4	2008	Calculation results together with some experimental data showed that, upon direct H bonding at the C=O group, the nuC=O frequencies downshift from the free value (1770-1780 cm(-1) in an Ar matrix) to 1745-1760 cm(-1), while H bonding at the OH hydrogen induce even larger downshifts to provide the frequencies at 1720-1745 cm(-1).	Hydrogen	244-252	nucleobindin 1	Homo sapiens	114-117
18452327-6	2008	In double and multiple H-bond forms, H-bonding effects at individual sites are basically additive, and complexes in which the C=O and the OH hydrogen are simultaneously H bonded exhibit significantly low nuC=O frequencies at 1725-1700 cm(-1), while complexes H bonded at the oxygen of the COH in addition to either at the C=O or the OH hydrogen exhibit medium frequencies of 1740-1765 cm(-1).	Hydrogen	141-149	nucleobindin 1	Homo sapiens	204-207
26596428-2	2011	We examine the dynamical nature of the hydrogen bonding in the high and low temperature phases of bulk KDP and find evidence to support the theory that hydrogen atoms oscillate between two off-center positions in the high-temperature phase.	Hydrogen	39-47	WNK lysine deficient protein kinase 1	Homo sapiens	103-106
18302366-3	2008	In particular, the transition states for both forms are stabilized by the intramolecular hydrogen bonds between the prolyl nitrogen and the N-H group of the Phe3 residue.	Hydrogen	89-97	dihydrolipoamide dehydrogenase	Homo sapiens	157-161
12833539-3	2003	The docking model, for either AgTX2 or ChTX with the Kv1.3 channel, predicts a novel hydrogen bonding interaction between the Asn30 side-chain of the peptide and the Asp381 side-chain of the channel.	Hydrogen	85-93	potassium voltage-gated channel subfamily A member 3	Homo sapiens	53-58
12846569-0	2003	Active peptidic mimics of the second intracellular loop of the V(1A) vasopressin receptor are structurally related to the second intracellular rhodopsin loop: a combined 1H NMR and biochemical study.	Hydrogen	170-172	arginine vasopressin receptor 1A	Homo sapiens	63-89
26596428-2	2011	We examine the dynamical nature of the hydrogen bonding in the high and low temperature phases of bulk KDP and find evidence to support the theory that hydrogen atoms oscillate between two off-center positions in the high-temperature phase.	Hydrogen	152-160	WNK lysine deficient protein kinase 1	Homo sapiens	103-106
26596428-4	2011	We find a strongly hydrogen bound water layer close to the KDP surface, comparing closely to a highly ordered water layer observed experimentally.	Hydrogen	19-27	WNK lysine deficient protein kinase 1	Homo sapiens	59-62
12801512-15	2003	With respect to receptor uptake, all the IC2 mutants endocytosed as WT BKB2R (60% in 1h).	Hydrogen	85-87	dynein cytoplasmic 1 intermediate chain 2	Homo sapiens	41-44
18031291-8	2008	Because Asp(66) forms hydrogen bonds with several other residues in the OXA-1 active site, we propose that this residue plays a role in stabilizing the CO2 bound to Lys(70) and thereby profoundly affects substrate turnover.	Hydrogen	22-30	beta-lactamase OXA-1 precursor	Escherichia coli	72-77
21553826-0	2011	Photodeposition of Ag2S quantum dots and application to photoelectrochemical cells for hydrogen production under simulated sunlight.	Hydrogen	87-95	angiotensin II receptor type 1	Homo sapiens	19-23
12738753-6	2003	After adjustment for multiple covariates, there was evidence for the heritability of apoA-II levels (h2=0.15; P&lt;0.02) in this sample.	Hydrogen	101-103	apolipoprotein A-II	Mus musculus	85-92
21553826-6	2011	Under illumination of one sun, the Ag(2)S photoanode cell yielded H(2) at a rate of 0.8 mL h(-1) with a total conversion efficiency of 0.29%, whereas the Ag/mp-TiO(2)/FTO photoanode is inactive.	Hydrogen	66-70	angiotensin II receptor type 1	Homo sapiens	35-41
18086840-8	2008	Molecular dynamics simulations of both the monomeric and the dimeric forms of MIP-3alpha supported the notion that the chemokine undergoes a change in helix angle upon dimerization and also highlighted the important hydrophobic and hydrogen bonding contacts made by His40 in the dimer interface.	Hydrogen	232-240	C-C motif chemokine ligand 20	Homo sapiens	78-88
21539779-6	2011	Ultraviolet resonance Raman spectra of Trp-170 and Trp-7 reveal evolution of a hydrogen bond in a nonpolar environment during the folding reaction, evidenced by systematic shifts in hydrophobicity and hydrogen bond markers.	Hydrogen	79-87	transient receptor potential cation channel subfamily C member 7	Homo sapiens	51-56
18307332-6	2008	Top ranking GANDI molecules are involved in one to three hydrogen bonds with the backbone polar groups in the hinge region of CDK2, an interaction pattern observed in potent kinase inhibitors.	Hydrogen	57-65	cyclin dependent kinase 2	Homo sapiens	126-130
12773039-4	2003	Common chemical features in the steroid and nonsteroid human CYP17 enzyme inhibitors, as deduced by the Catalyst/HipHop program, are one to two hydrogen bond acceptors (HBAs) and three hydrophobic groups.	Hydrogen	144-152	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	61-66
12773039-6	2003	A model that permits hydrogen bond interaction between the azole functionality on ring D and the enzyme is consistent with experimental deductions for type II CYP17 inhibitors where a sixth ligating atom interacts with Fe(II) of heme.	Hydrogen	21-29	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	159-164
21539779-6	2011	Ultraviolet resonance Raman spectra of Trp-170 and Trp-7 reveal evolution of a hydrogen bond in a nonpolar environment during the folding reaction, evidenced by systematic shifts in hydrophobicity and hydrogen bond markers.	Hydrogen	201-209	transient receptor potential cation channel subfamily C member 7	Homo sapiens	51-56
21332622-4	2011	These enzymes are crucial for interspecies formate and hydrogen transfer between propionate degrading Syntrophobacter spp.	Hydrogen	55-63	histocompatibility minor 13	Homo sapiens	118-121
12739969-2	2003	The mu2-silylene-bridged iron complexes [Cp(OC)(2)Fe](2)SiX(2) (X = F (2), Br (4), I (5)) have been prepared from the mu2-SiH(2) functional precursor [Cp(OC)(2)Fe](2)SiH(2) (1) by hydrogen/halogen exchange, using HBF(4), CBr(4), and CH(2)I(2), respectively.	Hydrogen	180-188	adaptor related protein complex 1 subunit mu 2	Homo sapiens	4-7
17910058-3	2008	LRH-1/phospholipid and LRH-1/SHP (fragments) interactions are analyzed by counting atomic contact number, identifying hydrogen bonds, and estimating binding free energies (by MM-PB/SA and N-mode analysis).	Hydrogen	118-126	nuclear receptor subfamily 0 group B member 2	Homo sapiens	29-32
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Hydrogen	197-205	serine protease 3	Homo sapiens	26-37
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Hydrogen	197-205	serine protease 3	Homo sapiens	133-144
18029098-10	2008	Using three-dimensional computer modeling analysis, CoQ(10) was considered to interact with the geminin interaction interface on Cdt1, and was assumed to make hydrogen bonds with the residue of Arg243 of Cdt1.	Hydrogen	159-167	chromatin licensing and DNA replication factor 1	Homo sapiens	204-208
18060868-3	2008	The expression of BMZF3 transcripts in the human neuroblastoma cell line TGW increased 1h after GDNF stimulation, as determined by Northern blotting and quantitative reverse-transcriptase polymerase chain reaction.	Hydrogen	87-89	zinc finger protein 256	Homo sapiens	18-23
17336058-2	2008	The hydrogen recoveries (mg gaseous H(2) produced as COD/mg added substrate COD) for glucose-fed batch systems were equal, 20.2-21.5%, between biosolids pellets and boiled anaerobic digester sludge as inoculum sources.	Hydrogen	36-40	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	53-56
17936362-9	2008	Thus, the time keeping oscillations of ECTO-NOX proteins appear to reflect the equilibrium dynamics of ortho-para hydrogen atom spin ratios of water where the presence of metal cations such as Cu(II) in solution determine period length.	Hydrogen	114-122	tripartite motif containing 33	Homo sapiens	39-43
21200842-3	2007	The structure is stabilized by C-H N and intermolecular C-H O hydrogen-bonding inter-actions.	Hydrogen	62-70	chimerin 1	Homo sapiens	31-59
17983687-8	2007	A MD trajectory of the A7R/NRP-1 complex in explicit water, based on the recent tuftsin/NRP-1 crystal structure, has revealed the hydrogen-bonding network that contributes to A7R"s binding activity.	Hydrogen	130-138	neuropilin 1	Homo sapiens	27-32
17983687-8	2007	A MD trajectory of the A7R/NRP-1 complex in explicit water, based on the recent tuftsin/NRP-1 crystal structure, has revealed the hydrogen-bonding network that contributes to A7R"s binding activity.	Hydrogen	130-138	neuropilin 1	Homo sapiens	88-93
18047119-5	2007	The ball-milled, nano-sized HAp powder, which has an average particle size of 70 nm, was fully densified at 1300 degrees C for 1h.	Hydrogen	127-129	reticulon 3	Homo sapiens	28-31
17764690-3	2007	Hydrogen-exchange mass spectrometry was used to study the structural and conformational changes undergone by full-length human Hsp90beta in solution upon binding of the kinase-specific co-chaperone Cdc37 and two Hsp90 ATPase inhibitors: Radicicol and the first-generation anticancer drug DMAG.	Hydrogen	0-8	cell division cycle 37, HSP90 cochaperone	Homo sapiens	198-203
17917276-5	2007	The improved heat stability of Rb(1) brought about by the addition of L-arginine was thought to be closely related to its characteristics of interfering with nonenzymatic glycation and forming hydrogen bonds with Rb(1).	Hydrogen	193-201	RB transcriptional corepressor 1	Homo sapiens	31-36
17917276-5	2007	The improved heat stability of Rb(1) brought about by the addition of L-arginine was thought to be closely related to its characteristics of interfering with nonenzymatic glycation and forming hydrogen bonds with Rb(1).	Hydrogen	193-201	RB transcriptional corepressor 1	Homo sapiens	213-218
17851595-1	2007	The adsorption of H(2) in a cross-linked poly(styrene-co-divinylbenzene) (St-DVB) microporous polymer (BET surface area 920 m(2) g(-1)) is studied by volumetric and gravimetric methods, FTIR spectroscopy at variable temperature (300-14 K) and ab initio calculations.	Hydrogen	18-22	delta/notch like EGF repeat containing	Homo sapiens	103-106
17663548-3	2007	Addition of SnCl4 to a THF solution of H2[OPO] in the presence of 2 equiv of NEt3 at room temperature led to the formation of the "ate" complex {[OPO]SnCl3}(HNEt3).	Hydrogen	39-41	tetraspanin 2	Homo sapiens	77-81
17637991-11	2007	A single-crystal X-ray diffraction study of [23]PF6 shows that the cation has an approximately A-frame geometry, with a Pt-Pt separation of 2.7888(3) A and a Pt-H bond length of 1.62(1) A, and that the 5-methyl substituents have undergone partial exchange with the 4-hydrogen atoms of the PPh2 groups of the bridging carbanion.	Hydrogen	267-275	sperm associated antigen 17	Homo sapiens	48-51
17548055-6	2007	Two days after induction of transient focal cerebral ischemia (1h), we found a significant decrease of the infarct volume in TLR2 deficient mice compared to wild type mice (75+/-5 vs. 42+/-7 mm(3)).	Hydrogen	63-65	toll-like receptor 2	Mus musculus	125-129
19636846-0	2007	1H, 13C and 15N resonance assignments of the bb" domains of human protein disulfide isomerase.	Hydrogen	0-2	prolyl 4-hydroxylase subunit beta	Homo sapiens	66-93
17512009-2	2007	In Hyb-24DN, Asp181-O(delta) forms hydrogen bonds with Tyr170-O(eta), -two of the catalytic and binding amino acids, and a loop between Asn167 and Val177.	Hydrogen	35-43	endothelin receptor type A	Homo sapiens	64-67
17512009-5	2007	By the combined effect, Tyr170-O(eta) moves a total of 10.5 A, resulting in the formation of hydrogen bonds with the nitrogen of amide linkage in Ald (closed form).	Hydrogen	93-101	endothelin receptor type A	Homo sapiens	33-36
17434734-2	2007	These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.	Hydrogen	25-33	cathepsin D	Homo sapiens	133-144
17503819-6	2007	To further validate the direct interaction model we show that, in urea and guanidinium chloride solutions, unfolding of an unusually stable helix (H1) from mouse PrPC (residues 144-153) occurs by hydrogen bonding of denaturants to charged side chains and backbone carbonyl groups.	Hydrogen	196-204	prion protein	Mus musculus	162-166
17465549-1	2007	The kinetics of reaction of the dihydrogen complex trans-[FeH(eta2-H2)(dppe)2]+ with an excess of NEt3 to form cis-[FeH2(dppe)2] shows a first-order dependence with respect to both the metal complex and the base.	Hydrogen	32-42	DNA polymerase iota	Homo sapiens	62-66
17465549-1	2007	The kinetics of reaction of the dihydrogen complex trans-[FeH(eta2-H2)(dppe)2]+ with an excess of NEt3 to form cis-[FeH2(dppe)2] shows a first-order dependence with respect to both the metal complex and the base.	Hydrogen	32-42	tetraspanin 2	Homo sapiens	98-102
17464397-5	2007	However, there is a slight difference between the PBE and B3LYP approach for the geometry of the hydrogen bonded network on the hydroxylated surface.	Hydrogen	97-105	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	50-53
17464397-6	2007	The PBE adsorption energy of CO on a surface silanol site is in good agreement with experimental values, suggesting that this method is more accurate for hydrogen bonded structures than B3LYP.	Hydrogen	154-162	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	4-7
17425306-4	2007	The YbIII analogue, YbL1, was prepared and characterized by 1H NMR.	Hydrogen	60-62	DNA polymerase epsilon 3, accessory subunit	Homo sapiens	20-24
17388551-16	2007	Evidence is presented that the intramolecular OHN hydrogen bond of PLP aldimines is broken in aqueous solution.	Hydrogen	50-58	pyridoxal phosphatase	Homo sapiens	67-70
19839404-5	2007	Molecular modeling (docking) studies showed that the methoxy group is positioned in the vicinity of COX-2 secondary pocket and it also participates in hydrogen bonding interactions in the COX-2 active site.	Hydrogen	151-159	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	100-105
19839404-5	2007	Molecular modeling (docking) studies showed that the methoxy group is positioned in the vicinity of COX-2 secondary pocket and it also participates in hydrogen bonding interactions in the COX-2 active site.	Hydrogen	151-159	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	188-193
12696880-3	2003	One such interaction involves Tyr325 in human phenylalanine hydroxylase (hPAH), which forms a hydrogen-bonding network with an aqua ligand on iron and the pterin cofactor.	Hydrogen	94-102	phenylalanine hydroxylase	Homo sapiens	46-71
12696880-3	2003	One such interaction involves Tyr325 in human phenylalanine hydroxylase (hPAH), which forms a hydrogen-bonding network with an aqua ligand on iron and the pterin cofactor.	Hydrogen	94-102	phenylalanine hydroxylase	Homo sapiens	73-77
12679486-6	2003	Molecular modeling and dynamic simulation of the Ala(171)Thr GnRH receptor suggests the introduction of a stable hydrogen bond between residue Thr(171) and Tyr(119) side-chains at a distance of 2 A.	Hydrogen	113-121	gonadotropin releasing hormone receptor	Homo sapiens	61-74
12679486-7	2003	Although spatially distant from the GnRH ligand-binding site, this hydrogen bond impedes conformational mobility of the TMH3 and TMH4 domains required for sequential ligand binding and receptor activation, thus stabilizing the GnRH receptor in its inactive conformation.	Hydrogen	67-75	gonadotropin releasing hormone receptor	Homo sapiens	227-240
12671048-1	2003	Endothelial cell production of anticoagulant heparan sulfate (HS(act)) is controlled by the Hs3st1 gene, which encodes the rate-limiting enzyme heparan sulfate 3-O-sulfotransferase-1 (3-OST-1).	Hydrogen	62-64	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	Mus musculus	92-98
12649439-4	2003	These data were complemented by hydrogen/deuterium (H/D) exchange measurements, which illustrated enhanced protection of slowly-exchanging IL-2 NH protons near the site of interaction with IL-2Ralpha.	Hydrogen	32-40	interleukin 2 receptor subunit alpha	Homo sapiens	189-199
12703775-0	2003	Zero-CO2 emission and low-crossover "rechargeable" PEM fuel cells using cyclohexane as an organic hydrogen reservoir.	Hydrogen	98-106	mucin 1, cell surface associated	Homo sapiens	51-54
12600215-4	2003	Recent studies revealed that mutation of a conserved proximal tryptophan-409, which forms one of three hydrogen bonds to the heme-coordinated cysteine thiolate, to tyrosine or phenylalanine considerably increases the turnover number of neuronal NOS (nNOS).	Hydrogen	103-111	nitric oxide synthase 1	Homo sapiens	236-248
12600215-4	2003	Recent studies revealed that mutation of a conserved proximal tryptophan-409, which forms one of three hydrogen bonds to the heme-coordinated cysteine thiolate, to tyrosine or phenylalanine considerably increases the turnover number of neuronal NOS (nNOS).	Hydrogen	103-111	nitric oxide synthase 1	Homo sapiens	250-254
12713234-5	2003	The value of -0.54 V as found for TH is shifted to -0.49, -0.45, and -0.28 V (vs. NHE, pH = 7) when the surface is covered by 1, 2, and 4 wt% of H2[PtCl6], respectively.	Hydrogen	145-147	solute carrier family 9 member C1	Homo sapiens	82-85
12554940-4	2003	HDPR tightly interacts with ADA by means of six hydrogen bonds and is entirely enclosed within the active site.	Hydrogen	48-56	adenosine deaminase	Bos taurus	28-31
12572799-6	2003	Using 1H NMR-based metabonomics, it was possible to distinguish low/ normal SBP serum samples from borderline and high SBP samples.	Hydrogen	6-8	selenium binding protein 1	Homo sapiens	76-79
12572799-6	2003	Using 1H NMR-based metabonomics, it was possible to distinguish low/ normal SBP serum samples from borderline and high SBP samples.	Hydrogen	6-8	selenium binding protein 1	Homo sapiens	119-122
12464242-2	2003	From a consideration of specific interactions between drug substrates for human CYP2 family enzymes and the putative active sites of CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, it is likely that the number and disposition of hydrogen bond donor/acceptors and aromatic rings within the various P450 substrate molecules determines their enzyme selectivity and binding affinity, together with directing their preferred routes of metabolism by the CYP2 enzymes concerned.	Hydrogen	242-250	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	141-147
12464242-2	2003	From a consideration of specific interactions between drug substrates for human CYP2 family enzymes and the putative active sites of CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, it is likely that the number and disposition of hydrogen bond donor/acceptors and aromatic rings within the various P450 substrate molecules determines their enzyme selectivity and binding affinity, together with directing their preferred routes of metabolism by the CYP2 enzymes concerned.	Hydrogen	242-250	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	149-155
12465028-10	2002	The contact between the N-terminal portion of PLN and the pump is stabilized by a number of salt and hydrogen-bond bridges, which may be abolished by phosphorylation of PLN.	Hydrogen	101-109	phospholamban	Homo sapiens	46-49
12465028-10	2002	The contact between the N-terminal portion of PLN and the pump is stabilized by a number of salt and hydrogen-bond bridges, which may be abolished by phosphorylation of PLN.	Hydrogen	101-109	phospholamban	Homo sapiens	169-172
12405812-1	2002	A family of chiral organometallic triangles based on cis-Pt(PEt3)2 metallocorners and enantiopure atropisomeric bis(alkynyl) bridging ligands (L1-4) has been synthesized and characterized by 1H, 13C{1H}, and 31P{1H} NMR, UV-vis, and circular dichroism (CD) spectroscopies, FAB and MALDI-TOF mass spectrometry, and microanalysis.	Hydrogen	191-193	immunoglobulin kappa variable 1D-17	Homo sapiens	143-147
12398339-2	2002	Among the 10 common-featured models generated by program catalyst/HipHop, a hypothesis including a hydrogen-bond donor (HBD) and a hydrogen-bond acceptor lipid (HBA1) features was considered to be important in evaluating the OA activity.	Hydrogen	131-139	hemoglobin subunit alpha 1	Homo sapiens	161-165
12196629-1	2002	Native-state hydrogen exchange experiments under EX1 conditions can distinguish partially unfolded intermediates by their formation rates and identify the amide hydrogens exposed and protected in each.	Hydrogen	13-21	FERM domain containing 6	Homo sapiens	49-52
12196629-1	2002	Native-state hydrogen exchange experiments under EX1 conditions can distinguish partially unfolded intermediates by their formation rates and identify the amide hydrogens exposed and protected in each.	Hydrogen	161-170	FERM domain containing 6	Homo sapiens	49-52
12220491-0	2002	C-H...O hydrogen bonds in the nuclear receptor RARgamma--a potential tool for drug selectivity.	Hydrogen	8-16	retinoic acid receptor gamma	Homo sapiens	47-55
12220491-2	2002	The 1.4 A resolution crystal structure of the ligand binding domain of the retinoic acid receptor RARgamma complexed with the retinoid SR11254 reveals several types of C-H...O hydrogen bonds.	Hydrogen	176-184	retinoic acid receptor gamma	Homo sapiens	98-106
12137543-3	2002	In the case of molecules with two hydrogen bonds and alkoxy terminal chains filling the inner molecular space, the uncommon phase sequence Iso-D(h)-Iso(re)-SmA (series III-3) was detected.	Hydrogen	34-42	survival of motor neuron 1, telomeric	Homo sapiens	156-159
12121079-4	2002	OD is formed from both alkenes, indicating a pathway of hydroxyl-radical formation involving vinylic hydrogens, accounting for one-third of total OH formation from cis-3-hexene.	Hydrogen	101-110	suppressor of cytokine signaling 3	Homo sapiens	164-169
12087557-2	2002	Defects of AE1 at the basolateral membrane of alpha-intercalated cells may result in the failure of hydrogen ion secretion at the apical membrane, leading to distal renal tubular acidosis (dRTA).	Hydrogen	100-108	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	11-14
12121148-2	2002	Continuous hydrogen gas production was observed when the reaction mixture containing sucrose, invertase, GDH, nicotinamide adenine dinucleotide (NAD(+)), Mg Chl-a, methyl viologen (MV(2+), an electron relay reagent), and colloidal platinum was irradiated by visible light.	Hydrogen	11-19	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	105-108
12069592-6	2002	We propose that this difference in stability is due to hydrogen bonds between the polar headgroup of PI and PG and the lipid-binding site of PI-TPalpha.	Hydrogen	55-63	phosphatidylinositol transfer protein alpha	Homo sapiens	141-151
12222686-4	2002	These contacts, which are different in Msh2 and Msh6, likely facilitate stacking and hydrogen bonding interactions between side chains in Msh6 and the mismatched base, thus stabilizing a kinked DNA conformation that permits subsequent repair steps coordinated by the Mlh1-Pms1 heterodimer.	Hydrogen	85-93	mismatch repair ATPase MLH1	Saccharomyces cerevisiae S288C	267-271
12223070-3	2002	Sodium-hydrogen exchange (NHE) is a key target for the treatment of heart failure.	Hydrogen	7-15	solute carrier family 9 member C1	Homo sapiens	26-29
11950482-6	2002	(2) After application of hCG for 1h, vasoconstriction by ANG II was significantly attenuated in MA.	Hydrogen	33-35	chorionic gonadotropin subunit beta 5	Homo sapiens	25-28
11997013-3	2002	The 20 structures of moricin in methanol have been determined from two-dimensional 1H-nuclear magnetic resonance spectroscopic data.	Hydrogen	83-85	moricin-2	Bombyx mori	21-28
11933067-6	2002	With the examples of halorhodopsin, calcium-transporting ATPase, and bovine cytochrome c oxidase, we discuss the roles of hydrogen bonds in stabilizing helical bundles in polytopic membrane proteins and in protein functions.	Hydrogen	122-130	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	76-96
11884147-9	2002	In addition, PDZ2 specifically binds the C termini of both human Fas/CD95 receptor and the RIL protein, despite RIL containing a non-canonical PDZ-interacting sequence of E-x-V. A model of PDZ2 with the RIL peptide reveals that the PDZ2 binding pocket is able to accommodate the bulkier side-chain of glutamic acid while maintaining crucial protein to peptide hydrogen bond interactions.	Hydrogen	360-368	PDZ and LIM domain 4	Homo sapiens	91-94
11883784-0	2002	1H, 15N and 13C resonance assignments of rabbit apo-S100A11.	Hydrogen	0-2	protein S100-A11	Oryctolagus cuniculus	52-59
11883784-6	2002	This work reports the 1H, 15N and 13C resonance assignments of rabbit apo-S100A11 determined using 15N, 13C-labelled protein and multidimensional NMR spectroscopy.	Hydrogen	22-24	protein S100-A11	Oryctolagus cuniculus	74-81
11842410-1	2002	The coupling of nuC-O and deltaO-D vibrations in the 1200-900 cm(-1) IR range leads to band shifting in opposite directions, which provides information on intramolecular hydrogen bonding of carbohydrates in aqueous solution.	Hydrogen	170-178	nucleobindin 1	Homo sapiens	16-19
11842410-3	2002	Frequency upshifting upon deuteration is observed for the nuC-O bands of both a hydrogen bond acceptor and donor in ether-hydroxyl and hydroxyl-hydroxyl contacts.	Hydrogen	80-88	nucleobindin 1	Homo sapiens	58-61
12197664-7	2002	Moreover, four to eight hydrogen bonds between hydroxamates and MMP-2 are formed to stabilize the inhibitors in the active site.	Hydrogen	24-32	matrix metallopeptidase 2	Homo sapiens	64-69
11744064-2	2001	The internal axial ligand of the heme, Cys415, may hydrogen-bond to the side chain of the conserved Arg418 residue in neuronal NOS (nNOS).	Hydrogen	51-59	nitric oxide synthase 1	Homo sapiens	118-130
11744064-2	2001	The internal axial ligand of the heme, Cys415, may hydrogen-bond to the side chain of the conserved Arg418 residue in neuronal NOS (nNOS).	Hydrogen	51-59	nitric oxide synthase 1	Homo sapiens	132-136
11726699-6	2001	The data show that RepA contacts the N3 proton of T at position +7 and that the T=A hydrogen bonds are already broken in the DNA before RepA binds.	Hydrogen	84-92	replication protein RepA	Escherichia phage P1	136-140
11714264-6	2001	A novel hydrogen exchange labeling-quench strategy, employing a high-affinity ligand to displace Cdc42 from WASP, was used to examine the amide exchange from the Cdc42-bound state of GBD-C.	Hydrogen	8-16	cell division cycle 42	Homo sapiens	97-102
11514561-7	2001	Furthermore, we showed that the affinity for the cofactor is higher in the human 3alpha-HSD3 than the rat enzyme due to the presence of additional hydrogen bonds on the adenine moiety and that the cofactor is present under its reduced form in the active site in our preparation.	Hydrogen	147-155	aldo-keto reductase family 1 member C2	Homo sapiens	81-92
11689073-5	2001	Using the program Autodock, we show that the iridals dock to the same position on the C1b domain of protein kinase C delta as do the phorbol esters, with the primary hydroxyl group of the iridal at the C3 position forming two hydrogen bonds with the amide group of Thr12 and with the carbonyl group of Leu 21 and the aldehyde oxygen of the iridal forming a hydrogen bond with the amide group of Gly23.	Hydrogen	226-234	protein kinase C delta	Homo sapiens	100-122
11689073-5	2001	Using the program Autodock, we show that the iridals dock to the same position on the C1b domain of protein kinase C delta as do the phorbol esters, with the primary hydroxyl group of the iridal at the C3 position forming two hydrogen bonds with the amide group of Thr12 and with the carbonyl group of Leu 21 and the aldehyde oxygen of the iridal forming a hydrogen bond with the amide group of Gly23.	Hydrogen	357-365	protein kinase C delta	Homo sapiens	100-122
11504729-2	2001	Both reactions have properties, including a tolerance of base analog substitutions that tend to eliminate major groove hydrogen bonding potential, that suggest a common molecular process underlies the DNA strand exchange promoted by RecA and Rad51.	Hydrogen	119-127	recombinase RAD51	Saccharomyces cerevisiae S288C	242-247
11710060-6	2001	The dynamics and structures were in clear contrast to those of CDA where a solvent-mediated hydrogen bonding between intermolecular C-6 position hydroxyls was essential to cluster formation.	Hydrogen	92-100	complement C6	Homo sapiens	132-135
11513604-12	2001	A crystal structure of the complex of RNase A with 2"-deoxyuridine 3"-pyrophosphate (P"--&gt;5") adenosine (dUppA), determined at 1.7 A resolution, together with models of the UppA complex based on this structure suggest that His119 contributes to UppA cleavage through a hydrogen bond with a nonbridging oxygen atom in the pyrophosphate and through pi-pi stacking with the six-membered ring of adenine.	Hydrogen	272-280	ribonuclease A family member 1, pancreatic	Homo sapiens	38-45
11468363-5	2001	Phosphate binds to the catalytic site of both Ang and Q117G in essentially the same manner observed in the RNase A-phosphate complex, forming hydrogen bonds with the side chains of His 13, His 114, and Gln 12, and the main chain of Leu 115; it makes an additional interaction with the Lys 40 ammonium group in the Ang complex.	Hydrogen	142-150	angiogenin	Homo sapiens	46-49
11297543-1	2001	Glutaredoxin (Grx) is a glutathione-dependent hydrogen donor for ribonucleotide reductase.	Hydrogen	46-54	glutaredoxin	Homo sapiens	0-12
11297543-1	2001	Glutaredoxin (Grx) is a glutathione-dependent hydrogen donor for ribonucleotide reductase.	Hydrogen	46-54	glutaredoxin	Homo sapiens	14-17
11518188-1	2001	The myocardial sodium-hydrogen exchanger (NHE), and more specifically the NHE-1 isoform is now well-recognized to be a major contributor to ischemic and reperfusion injury.	Hydrogen	22-30	solute carrier family 9 member C1	Homo sapiens	42-45
11388900-3	2001	We found that two local vibrational modes of kainate, which were also observed in glutamate but not in CNQX, interacted through hydrogen bonds with the vibrational modes of GluR2: (i) the bending vibration of the amine group of kainate, interacting with the stretching vibration of the carboxyl group of Glu705 of GluR2, and (ii) the symmetric stretching vibration of the carboxyl group of kainate, interacting with the bending vibration of the guanidinium group of Arg485.	Hydrogen	128-136	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	173-178
11388900-3	2001	We found that two local vibrational modes of kainate, which were also observed in glutamate but not in CNQX, interacted through hydrogen bonds with the vibrational modes of GluR2: (i) the bending vibration of the amine group of kainate, interacting with the stretching vibration of the carboxyl group of Glu705 of GluR2, and (ii) the symmetric stretching vibration of the carboxyl group of kainate, interacting with the bending vibration of the guanidinium group of Arg485.	Hydrogen	128-136	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	314-319
11137548-1	2001	Minute amount of Brevetoxin PbTx-3 (400 microg; 0.446 micromol) was converted into an hemisuccinate derivative (PbTx-3 HS) then covalently linked to bovine serum albumin (BSA) and ovalbumin (OVA) in a reversed micellar medium.	Hydrogen	119-121	albumin	Mus musculus	156-175
11457277-8	2001	An alternative pathway was suggested by modeling Lys266 to have a hydrogen-bonding interaction with the N3 of the imidazole of AICAR.	Hydrogen	66-74	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	127-132
11377199-8	2001	Conformational changes also result in subtle differences in hydrogen bonding and electrostatic interactions between E226"s sulphonate and CDK2"s phosphate binding site.	Hydrogen	60-68	cyclin dependent kinase 2	Homo sapiens	138-142
11742589-2	2001	METHODS: rCBF was determined in the hippocampus by the hydrogen clearance method.	Hydrogen	55-63	CCAAT/enhancer binding protein zeta	Rattus norvegicus	9-13
11445344-1	2001	1H-MRI has been applied to the evaluation of the performances of a hydrophobic polymer (Paraloid B72), widely used for the conservation of monumental buildings and other stone artifacts.	Hydrogen	0-2	CD86 molecule	Homo sapiens	97-100
11237702-2	2001	According to the crystal structure of other NOS isoforms, the carboxylate group of l-Arg hydrogen bonds to the hydroxyl group of the conserved Tyr588 residue in the heme distal site of neuronal NOS (nNOS).	Hydrogen	89-97	nitric oxide synthase 1	Homo sapiens	185-197
11237702-2	2001	According to the crystal structure of other NOS isoforms, the carboxylate group of l-Arg hydrogen bonds to the hydroxyl group of the conserved Tyr588 residue in the heme distal site of neuronal NOS (nNOS).	Hydrogen	89-97	nitric oxide synthase 1	Homo sapiens	199-203
11207369-3	2001	It has a structure unlike any class I cytokine receptor described thus far, forming a stable interlocking dimer in the absence of ligand in which the G strand of domain 1 hydrogen bonds into the corresponding beta sheet of domain 3 of the dimer-related molecule.	Hydrogen	171-179	interleukin 27 receptor subunit alpha	Homo sapiens	30-55
11166795-6	2001	rCBF was measured in both parietal cortices concurrently by the hydrogen clearance.	Hydrogen	64-72	CCAAT/enhancer binding protein zeta	Rattus norvegicus	0-4
11205008-2	2001	These calculations reveal that the approach of an OH- ion leads to the formation of two distinct ion-molecule complexes: 1) the MS1 species with the hydroxide ion hydrogen bonded to the methyl group of the ester, and 2) the MS4 moiety resulting from proton abstraction of the formyl hydrogen by the hydroxide ion and formation of a three-body complex of water, methoxide ion and carbon monoxide.	Hydrogen	163-171	MS	Homo sapiens	128-131
11205008-2	2001	These calculations reveal that the approach of an OH- ion leads to the formation of two distinct ion-molecule complexes: 1) the MS1 species with the hydroxide ion hydrogen bonded to the methyl group of the ester, and 2) the MS4 moiety resulting from proton abstraction of the formyl hydrogen by the hydroxide ion and formation of a three-body complex of water, methoxide ion and carbon monoxide.	Hydrogen	163-171	MS4	Homo sapiens	224-227
11205008-2	2001	These calculations reveal that the approach of an OH- ion leads to the formation of two distinct ion-molecule complexes: 1) the MS1 species with the hydroxide ion hydrogen bonded to the methyl group of the ester, and 2) the MS4 moiety resulting from proton abstraction of the formyl hydrogen by the hydroxide ion and formation of a three-body complex of water, methoxide ion and carbon monoxide.	Hydrogen	283-291	MS	Homo sapiens	128-131
11205008-2	2001	These calculations reveal that the approach of an OH- ion leads to the formation of two distinct ion-molecule complexes: 1) the MS1 species with the hydroxide ion hydrogen bonded to the methyl group of the ester, and 2) the MS4 moiety resulting from proton abstraction of the formyl hydrogen by the hydroxide ion and formation of a three-body complex of water, methoxide ion and carbon monoxide.	Hydrogen	283-291	MS4	Homo sapiens	224-227
11257443-5	2001	We found that 1-[6-[[17beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione (U73122), an inhibitor of phospholipase C (PLC), suppressed both opsonized zymosan (OZ)-induced dephosphorylation and translocation of cofilin in macrophage-like U937 cells at 4 microM concentration.	Hydrogen	78-80	cofilin 1	Homo sapiens	234-241
11087354-9	2000	With the existence of pGlu1, the conformation of the N-terminus allows two additional interactions between the two subunits of MCP-2 dimer: a hydrogen bond between pGlu1 and Asn17 and a salt bridge between Asp3 and Arg18.	Hydrogen	142-150	C-C motif chemokine ligand 8	Homo sapiens	127-132
11128276-4	2000	The Co complex 4a with PF6- counterions builds a two-dimensional infinite interwoven grid through strong double hydrogen bonds (d(N-H-N) =2.918-3.018 A) between the amino groups and the N atoms of the rings, with all H-bonding sites saturated.	Hydrogen	112-120	sperm associated antigen 17	Homo sapiens	23-26
11051090-10	2000	Other enzymes whose mechanisms appear to involve low-barrier hydrogen bonds include liver alcohol dehydrogenase, steroid isomerase, triose-P isomerase, aconitase, citrate synthase, and zinc proteases.	Hydrogen	61-69	citrate synthase	Homo sapiens	163-179
21754104-4	2011	The dimers are connected by C-H N and C-H O hydrogen bonds.	Hydrogen	44-52	chimerin 1	Homo sapiens	28-41
10899783-7	2000	On the other hand, our hydrogen exchange study of the molten globule of canine milk lysozyme showed that the alpha-helices are more stabilized than in alpha-lactalbumin or equine milk lysozyme and that this enhanced stability is caused by the strengthened cooperative interaction between secondary structure elements.	Hydrogen	23-31	lactalbumin alpha	Canis lupus familiaris	151-168
20821410-0	2011	Long-TE 1H MRS suggests that liver fat is more saturated than subcutaneous and visceral fat.	Hydrogen	8-10	FAT atypical cadherin 1	Homo sapiens	35-38
10952304-0	2000	Pixel switching of epitaxial Pd/YHx/CaF2 switchable mirrors Exposure of rare-earth films to hydrogen can induce a metal-insulator transition, accompanied by pronounced optical changes.	Hydrogen	92-100	CCR4-NOT transcription complex subunit 8	Homo sapiens	36-40
21353782-3	2011	The X-ray crystallographic data of compound 12 bound to the active site of squalene synthase provided an important insight into the binding mode of this alternative template that formed 11-membered ring conformations with an intramolecular hydrogen bond.	Hydrogen	240-248	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	75-92
11014594-2	2000	Specifically, the remote correlation between the guanidinium nitrogen 15Nepsilon of arginine 71, which serves as the hydrogen donor, and the acceptor carboxylate carbon 13CO2gamma of aspartate 100 in a 12 kDa protein, human FKBP12, is detected via the trans-hydrogen bond 3h JNepsilonCO2gamma coupling by employing a novel HNCO-type experiment, soft CPD-HNCO.	Hydrogen	117-125	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	224-230
11014594-2	2000	Specifically, the remote correlation between the guanidinium nitrogen 15Nepsilon of arginine 71, which serves as the hydrogen donor, and the acceptor carboxylate carbon 13CO2gamma of aspartate 100 in a 12 kDa protein, human FKBP12, is detected via the trans-hydrogen bond 3h JNepsilonCO2gamma coupling by employing a novel HNCO-type experiment, soft CPD-HNCO.	Hydrogen	258-266	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	224-230
11014599-0	2000	1H, 13C, and 15N backbone assignments of the ligand binding domain of TGFbeta type II receptor.	Hydrogen	0-2	transforming growth factor beta receptor 2	Homo sapiens	70-94
11001096-12	2000	Indeed, subtle differences in the spectra of Mn2+, Fe3+ and 1H in the presence of Fe2+ distinguish the G77Q, Q146A mut-(Mn)SOD from WT (Mn)SOD, and may prove to be correlated with metal ion activity.	Hydrogen	60-62	superoxide dismutase 2	Homo sapiens	123-126
11001096-12	2000	Indeed, subtle differences in the spectra of Mn2+, Fe3+ and 1H in the presence of Fe2+ distinguish the G77Q, Q146A mut-(Mn)SOD from WT (Mn)SOD, and may prove to be correlated with metal ion activity.	Hydrogen	60-62	superoxide dismutase 2	Homo sapiens	139-142
21237148-6	2011	These findings suggested that directly injected IL-10 into the lateral cerebral ventricle 1h before intravenous LPS exerted its antipyresis by inhibiting the changes in extracellular glutamate, hydroxyl radicals and PGE(2) in the hypothalamus during LPS fever in rabbits.	Hydrogen	90-92	interleukin-10	Oryctolagus cuniculus	48-53
21040763-5	2011	In the present study, the pretreatment of Al(malt)3 at nonlethal level (200 muM, 24 h) significantly reduced BDNF (10 ng/ml, 1h)-induced Arc expression in SH-SY5Y human neuroblastoma cells.	Hydrogen	125-127	activity regulated cytoskeleton associated protein	Homo sapiens	137-140
11060730-2	2000	Extensive animal experiments have repeatedly demonstrated the efficacy of sodium-hydrogen exchange (NHE) inhibition as a potent cardioprotective approach.	Hydrogen	81-89	solute carrier family 9 member C1	Homo sapiens	100-103
12526550-0	2000	1H- and 2H-T1 relaxation behavior of the rhodium dihydrogen complex [(triphos)Rh(eta 2-H2)H2]+.	Hydrogen	0-2	DNA polymerase iota	Homo sapiens	81-86
21117647-7	2011	Through hydrogen-deuterium amide exchange with analysis by mass spectrometry, we found that the +7NEM-modified species incorporates approximately 40 more deuterium atoms than the native protein, which exchanges nearly identically as the +2NEM product, suggesting that APE1 can be trapped in a partially unfolded state.	Hydrogen	8-16	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	268-272
10776535-7	2000	The Cd1 value increases as the length of the aliphatic chain decreases and upon replacement of mobile hydrogen atoms in the ammonium fragment by methyl groups.	Hydrogen	102-110	CD1c molecule	Homo sapiens	4-7
17139481-4	2007	A hydrogen bond detected in HPr(Ser46P) between one phosphate-group oxygen and a side-chain hydrogen of Asn43-an amino acid conserved in all HPr proteins of Gram-positive bacteria that regulate their carbon consumption by CCR-might fulfil an important role in CcpA-HPr(Ser46P) complex formation.	Hydrogen	2-10	haptoglobin-related protein	Homo sapiens	28-31
17139481-4	2007	A hydrogen bond detected in HPr(Ser46P) between one phosphate-group oxygen and a side-chain hydrogen of Asn43-an amino acid conserved in all HPr proteins of Gram-positive bacteria that regulate their carbon consumption by CCR-might fulfil an important role in CcpA-HPr(Ser46P) complex formation.	Hydrogen	2-10	haptoglobin-related protein	Homo sapiens	141-144
17139481-4	2007	A hydrogen bond detected in HPr(Ser46P) between one phosphate-group oxygen and a side-chain hydrogen of Asn43-an amino acid conserved in all HPr proteins of Gram-positive bacteria that regulate their carbon consumption by CCR-might fulfil an important role in CcpA-HPr(Ser46P) complex formation.	Hydrogen	2-10	haptoglobin-related protein	Homo sapiens	141-144
17139481-4	2007	A hydrogen bond detected in HPr(Ser46P) between one phosphate-group oxygen and a side-chain hydrogen of Asn43-an amino acid conserved in all HPr proteins of Gram-positive bacteria that regulate their carbon consumption by CCR-might fulfil an important role in CcpA-HPr(Ser46P) complex formation.	Hydrogen	92-100	haptoglobin-related protein	Homo sapiens	28-31
17139481-4	2007	A hydrogen bond detected in HPr(Ser46P) between one phosphate-group oxygen and a side-chain hydrogen of Asn43-an amino acid conserved in all HPr proteins of Gram-positive bacteria that regulate their carbon consumption by CCR-might fulfil an important role in CcpA-HPr(Ser46P) complex formation.	Hydrogen	92-100	haptoglobin-related protein	Homo sapiens	141-144
10718292-2	2000	The purpose of this study was to measure brain levels of myo-inositol (ml), N-acetylaspartate (NAA), and other metabolites in Ts65Dn mice using in vivo 1H magnetic resonance spectroscopy (MRS), and to determine whether lithium (Li) treatment alters brain ml level.	Hydrogen	152-154	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	126-132
17139481-4	2007	A hydrogen bond detected in HPr(Ser46P) between one phosphate-group oxygen and a side-chain hydrogen of Asn43-an amino acid conserved in all HPr proteins of Gram-positive bacteria that regulate their carbon consumption by CCR-might fulfil an important role in CcpA-HPr(Ser46P) complex formation.	Hydrogen	92-100	haptoglobin-related protein	Homo sapiens	141-144
22455068-2	2011	In this paper, we examine the factors that determine the thermodynamics of hydrogen activation of a Lewis acid-base pair using the pedagogical examples of ammonia borane (NH3BH3, AB) and ammonium borohydride ([NH4][BH4], ABH2).	Hydrogen	75-83	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	221-225
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM &lt; IC50 &lt; 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Hydrogen	221-229	hemoglobin subunit alpha 1	Homo sapiens	195-199
10723996-0	2000	A novel experiment for the quantitative measurement of CSA(1H(N))/CSA(15N) cross-correlated relaxation in 15N-labeled proteins.	Hydrogen	59-61	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	55-58
10723996-1	2000	An experiment is presented which allows for the quantitative measurement of the relaxation interference between the 1H(N) CSA and 15N CSA interactions in 15N labeled proteins.	Hydrogen	116-118	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	122-125
10723996-4	2000	The CSA(1H(N))/CSA(15N) cross-correlation rate was obtained from the linear fit of the measured rate, eta, versus Bo2 for 77 residues of the EH2 domain from mouse Eps15.	Hydrogen	8-10	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	4-7
10723996-4	2000	The CSA(1H(N))/CSA(15N) cross-correlation rate was obtained from the linear fit of the measured rate, eta, versus Bo2 for 77 residues of the EH2 domain from mouse Eps15.	Hydrogen	8-10	epidermal growth factor receptor pathway substrate 15	Mus musculus	163-168
17266353-4	2007	In the new pathway, the PtCH2 + H2 products were formed via a transition state, in which the Pt atom forms a complex with carbene and both dissociated hydrogen atoms.	Hydrogen	151-159	patched 2	Homo sapiens	24-29
22455068-3	2011	At ambient temperatures, ABH2 loses hydrogen to form the Lewis acid-base complex AB, suggesting that free energy drives the reaction to release hydrogen.	Hydrogen	36-44	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	25-29
17126018-5	2007	Furthermore, 7-bromo-THBQ (19, hPNMT K(i)=0.22mM), which has a lipophilic 7-substituent that cannot hydrogen bond to the enzyme, is twice as potent at PNMT than 11.	Hydrogen	100-108	phenylethanolamine N-methyltransferase	Homo sapiens	31-36
17126018-5	2007	Furthermore, 7-bromo-THBQ (19, hPNMT K(i)=0.22mM), which has a lipophilic 7-substituent that cannot hydrogen bond to the enzyme, is twice as potent at PNMT than 11.	Hydrogen	100-108	phenylethanolamine N-methyltransferase	Homo sapiens	32-36
10716181-5	2000	Strand beta5 is hydrogen bonded to strands beta3 and beta4, both of which afford strong protection from solvent exchange.	Hydrogen	16-24	tubulin beta 4A class IVa	Homo sapiens	7-12
10716181-5	2000	Strand beta5 is hydrogen bonded to strands beta3 and beta4, both of which afford strong protection from solvent exchange.	Hydrogen	16-24	tubulin beta 3 class III	Homo sapiens	53-58
22455068-3	2011	At ambient temperatures, ABH2 loses hydrogen to form the Lewis acid-base complex AB, suggesting that free energy drives the reaction to release hydrogen.	Hydrogen	144-152	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	Homo sapiens	25-29
10633045-4	2000	In each case, the nitrogen at position-1 of the quinazoline accepted a hydrogen bond from a backbone NH (CDK2, Leu-83; p38, Met-109) of the domain connector strand, and aromatic hydrogen atoms at C2 and C8 interacted with backbone carbonyl oxygen atoms of the peptide strand.	Hydrogen	71-79	cyclin dependent kinase 2	Homo sapiens	105-109
22073283-7	2011	A hydrogen bond, formed between the 3-hydroxyl group of E(2) and His256 of PDI is critical for the binding interaction.	Hydrogen	2-10	prolyl 4-hydroxylase subunit beta	Homo sapiens	75-78
10601866-1	2000	The secondary structure and membrane-associated conformation of a synthetic peptide corresponding to the putative membrane-binding C-terminal 38 residues of the bovine milk component PP3 was determined using 1H NMR in methanol, CD in methanol and SDS micelles, and 15N solid-state NMR in planar phospholipid bilayers.	Hydrogen	208-210	glycosylation dependent cell adhesion molecule 1	Bos taurus	183-186
10587433-11	1999	In the substrate and product complexes, the halogen binds to the Xanthobacter enzyme via hydrogen bonds with the N(eta)H of both W125 and W175.	Hydrogen	89-97	endothelin receptor type A	Homo sapiens	115-118
21998672-5	2011	The molecular decoration of the alloxan core with a biphenyl privileged structure allowed to sample the deep S(1)" specificity pocket of MMP-2 and to relate the high affinity towards this enzyme with the chance of forming a hydrogen bond network with the backbone of Leu116 and Asn147 and the side chains of Tyr144, Thr145 and Arg149 at the bottom of the pocket.	Hydrogen	224-232	matrix metallopeptidase 2	Homo sapiens	137-142
10587433-13	1999	Instead, bound halide is stabilized with hydrogen bonds to the N(eta)H of W118 and to N(delta)H of N52.	Hydrogen	41-49	endothelin receptor type A	Homo sapiens	65-68
10587623-1	1999	The unfolding dynamics of cellular retinoic acid-binding protein I (CRABP I), an 18 kDa predominantly beta-sheet protein, were studied by monitoring the hydrogen-deuterium (H-D) exchange reaction under various solution conditions.	Hydrogen	153-161	cellular retinoic acid binding protein 1	Homo sapiens	26-66
10587623-1	1999	The unfolding dynamics of cellular retinoic acid-binding protein I (CRABP I), an 18 kDa predominantly beta-sheet protein, were studied by monitoring the hydrogen-deuterium (H-D) exchange reaction under various solution conditions.	Hydrogen	153-161	cellular retinoic acid binding protein 1	Homo sapiens	68-75
10587623-5	1999	At pH 2.5 and room temperature, three distinct populations of CRABP I ions exist over an extended period of time, each corresponding to a specific degree of backbone amide hydrogen atom protection.	Hydrogen	172-180	cellular retinoic acid binding protein 1	Homo sapiens	62-69
17201391-0	2007	Reaction of O2 with the hydrogen atom in water up to 350 degrees C. The reaction of the H* atom with O2, giving the hydroperoxyl HO2* radical, has been investigated in pressurized water up to 350 degrees C using pulse radiolysis and deep-UV transient absorption spectroscopy.	Hydrogen	24-32	heme oxygenase 2	Homo sapiens	129-132
17181219-0	2006	Mg1.8La0.2Ni-xNi nanocomposites for electrochemical hydrogen storage.	Hydrogen	52-60	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	0-3
17181219-1	2006	Mg1.8La0.2Ni hydrogen storage alloy was ball-milled with Ni powder, leading to the formation of a nanocrystalline and amorphous microstructure with particle sizes less than 50 nm in diameter.	Hydrogen	13-21	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	0-3
21036609-3	2010	Among them, compound 1h was identified as a highly selective DP1 antagonist with excellent overall properties.	Hydrogen	21-23	prostaglandin D2 receptor	Homo sapiens	61-64
32646097-4	2006	At pH 5, MePE-C32-MePE can form intermolecular hydrogen bonds between the headgroups, which causes a significantly higher stability of the nanofibrils up to at least 75  C. In contrast, no pronounced gelling properties are observed at pH 10.	Hydrogen	47-55	matrix extracellular phosphoglycoprotein	Homo sapiens	9-13
32646097-4	2006	At pH 5, MePE-C32-MePE can form intermolecular hydrogen bonds between the headgroups, which causes a significantly higher stability of the nanofibrils up to at least 75  C. In contrast, no pronounced gelling properties are observed at pH 10.	Hydrogen	47-55	matrix extracellular phosphoglycoprotein	Homo sapiens	18-22
10677831-0	1999	1H, 15N, and 13C resonance assignment of the PH domain from C. elegans UNC-89.	Hydrogen	0-2	Muscle M-line assembly protein unc-89	Caenorhabditis elegans	71-77
21036609-6	2010	These properties make 1h a very potent and highly selective DP1 receptor antagonist suitable for investigating the biological functions of DP1 in normal physiology and models of disease.	Hydrogen	22-24	prostaglandin D2 receptor	Homo sapiens	60-63
21036609-6	2010	These properties make 1h a very potent and highly selective DP1 receptor antagonist suitable for investigating the biological functions of DP1 in normal physiology and models of disease.	Hydrogen	22-24	prostaglandin D2 receptor	Homo sapiens	139-142
10390231-8	1999	In particular, a hydrogen at the C-6 position seemed to be responsible for major neurotoxic activity in comparison to an amino group located in the same position.	Hydrogen	17-25	complement component 6	Mus musculus	33-36
21077660-7	2010	Through AFM investigation of the formation and transformation of the peptides" supramolecular structures, we conclude that the peptides" self-assembly process was dominated by weak interactions, such as hydrophobic and electrostatic interactions and hydrogen bonding, between the peptide molecules, the mica substrate, and the water nanofilm.	Hydrogen	250-258	MHC class I polypeptide-related sequence A	Homo sapiens	303-307
10387046-0	1999	Solid state NMR studies of hydrogen bonding in a citrate synthase inhibitor complex.	Hydrogen	27-35	citrate synthase	Homo sapiens	49-65
17083258-5	2006	The new complexes [(p-cym)Ru(bpy)NO2]PF6 and fac-[Ru(bpy)(CH3CN)3NO2]PF6 have been fully characterized by 1H and 15N NMR, IR, elemental analysis, and single-crystal structure determination.	Hydrogen	106-108	sperm associated antigen 17	Homo sapiens	69-72
21086484-2	2010	X-ray crystal-structure analyses of 1b I, 1b PF(6), 2a I, and 4a I reveal bilayer structures in the solid state and, for the 1b and 1b PF(6) salts, a hydrogen-bond-type connectivity between the guanidinium N-H group and the anion is found.	Hydrogen	150-158	sperm associated antigen 17	Homo sapiens	45-50
16966328-1	2006	The crystal structure of the neuronal nitric-oxide synthase (nNOS) NADPH/FAD binding domain indicated that Ser-1176 is within hydrogen bonding distance of Asp-1393 and the O4 atom of FAD and is also near the N5 atom of FAD (3.7 A).	Hydrogen	126-134	nitric oxide synthase 1	Homo sapiens	29-59
16966328-1	2006	The crystal structure of the neuronal nitric-oxide synthase (nNOS) NADPH/FAD binding domain indicated that Ser-1176 is within hydrogen bonding distance of Asp-1393 and the O4 atom of FAD and is also near the N5 atom of FAD (3.7 A).	Hydrogen	126-134	nitric oxide synthase 1	Homo sapiens	61-65
16966328-9	2006	These data presented here suggest that hydrogen bonding of the hydroxyl group of serine or threonine with the isoalloxazine ring of FAD and with the amino acids in its immediate milieu, particularly nNOS Asp-1393, affects the redox potentials of various flavin states, influencing the rate of electron transfer.	Hydrogen	39-47	nitric oxide synthase 1	Homo sapiens	199-203
16868917-0	2006	1H and 13C NMR data for C-6 substituted 3-azabicyclo[3.3.1]nonane-1-carboxylates.	Hydrogen	0-2	complement C6	Homo sapiens	24-27
10320322-8	1999	Interaction of the 22-residue peptide PAK2(71-92) with GTP-gammaS-loaded Cdc42 causes resonance perturbations in the 1H-15N HSQC spectrum of Cdc42 that are similar to those observed for a longer (46-amino acid) CRIB-containing protein fragment [Guo, W., et al.	Hydrogen	117-119	p21 (RAC1) activated kinase 2	Homo sapiens	38-42
10320322-8	1999	Interaction of the 22-residue peptide PAK2(71-92) with GTP-gammaS-loaded Cdc42 causes resonance perturbations in the 1H-15N HSQC spectrum of Cdc42 that are similar to those observed for a longer (46-amino acid) CRIB-containing protein fragment [Guo, W., et al.	Hydrogen	117-119	cell division cycle 42	Homo sapiens	73-78
10092465-2	1999	To determine how additional interactions with surrounding structure affects local protein dynamics, we have used hydrogen exchange and mass spectrometry to investigate the SH2 and SH3 domains of the protein tyrosine kinase Hck.	Hydrogen	113-121	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	223-226
10194301-10	1999	However, a comparison of DNase I variants from several species suggests that certain amino acids, which allow interaction with phosphates (positively charged or hydrogen bonding), are tolerated.	Hydrogen	161-169	deoxyribonuclease 1	Bos taurus	25-32
21086484-2	2010	X-ray crystal-structure analyses of 1b I, 1b PF(6), 2a I, and 4a I reveal bilayer structures in the solid state and, for the 1b and 1b PF(6) salts, a hydrogen-bond-type connectivity between the guanidinium N-H group and the anion is found.	Hydrogen	150-158	sperm associated antigen 17	Homo sapiens	135-140
21151967-11	2010	Various inter-domain hydrogen bonds and switching of a salt-bridge network from E345-R350-E409 to E345-R169-E409 contributed to this ATP-mediated channel constriction favoring substrate occlusion and prevention of its release into cytoplasm.	Hydrogen	21-29	ATPase phospholipid transporting 8A2	Homo sapiens	133-136
10080895-9	1999	The smaller 1H-15N nuclear Overhauser enhancement values for the residues of loop 3 between beta2 and beta3 suggest that this loop is flexible in the time-scale of nano- to picosecond order.	Hydrogen	12-14	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	102-107
22062850-5	2006	The lower energy status led to AMPK activation within 1h postmortem, subsequently increasing glycolysis, leading to rapid glycolysis and high incidence of PSE meat.	Hydrogen	54-56	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	31-35
21355420-10	2010	The long pentadecyl chain of CTPB reduces the formation of hydrogen bond with the p300.	Hydrogen	59-67	E1A binding protein p300	Homo sapiens	82-86
16882659-7	2006	The small size of the serine side chain combined with its ability to form intra- and interhelical hydrogen bonds likely contributes to recognition of the signal sequence as a substrate for SPP.	Hydrogen	98-106	histocompatibility minor 13	Homo sapiens	189-192
10635357-2	1999	The structures of the products and their S-substituted derivatives [VII, VIII] were established on the basis of elemental analysis and spectral data (IR, 1H and 13C NMR).	Hydrogen	154-156	cytochrome c oxidase subunit 8A	Homo sapiens	73-77
21177481-8	2010	While distal from the site of transmethylation, the propanoid tail substituent governs the kinetic preference of ryegrass COMT for aldehydes over alcohols and acids due to a single hydrogen bond donor for the C9 oxygenated moiety dictating the preference for an aldehyde.	Hydrogen	181-189	catechol-O-methyltransferase	Homo sapiens	122-126
9988688-0	1999	Functional interaction of mammalian valyl-tRNA synthetase with elongation factor EF-1alpha in the complex with EF-1H.	Hydrogen	114-116	valyl-tRNA synthetase 1	Homo sapiens	36-57
9988688-1	1999	In mammalian cells valyl-tRNA synthetase (ValRS) forms a high Mr complex with the four subunits of elongation factor EF-1H.	Hydrogen	120-122	valyl-tRNA synthetase 1	Homo sapiens	19-40
9988688-1	1999	In mammalian cells valyl-tRNA synthetase (ValRS) forms a high Mr complex with the four subunits of elongation factor EF-1H.	Hydrogen	120-122	valyl-tRNA synthetase 1	Homo sapiens	42-47
16970413-3	2006	TSC is also found to induce order in the surrounding water structure through increased hydrogen bonding of the water molecules, and molecular simulations suggest that the increase in diffusivity occurs only in these ordered regions.	Hydrogen	87-95	solute carrier family 12 member 3	Homo sapiens	0-3
16942016-8	2006	We also report the crystal structure of hPNMT in complex with sulfonamide 15, from which a potential hydrogen bond acceptor within the hPNMT active site has been identified, the main chain carbonyl oxygen of Asn39.	Hydrogen	101-109	phenylethanolamine N-methyltransferase	Homo sapiens	40-45
9988688-2	1999	The beta, gamma, and delta subunits, that contribute the guanine nucleotide exchange activity of EF-1H, are tightly associated with the NH2-terminal polypeptide extension of valyl-tRNA synthetase.	Hydrogen	100-102	valyl-tRNA synthetase 1	Homo sapiens	174-195
16942016-8	2006	We also report the crystal structure of hPNMT in complex with sulfonamide 15, from which a potential hydrogen bond acceptor within the hPNMT active site has been identified, the main chain carbonyl oxygen of Asn39.	Hydrogen	101-109	phenylethanolamine N-methyltransferase	Homo sapiens	135-140
9988688-4	1999	We show here that the addition of EF-1alpha and GTP in excess in the aminoacylation mixture is accompanied by a 2-fold stimulation of valyl-tRNAVal synthesis catalyzed by the valyl-tRNA synthetase component of the ValRS.EF-1H complex.	Hydrogen	223-225	valyl-tRNA synthetase 1	Homo sapiens	175-196
20085672-7	2010	MRI-guided 1H-MRS (at 4.7 T) examinations in vivo (under anaesthesia) revealed changes in the bioenergetic metabolites (phosphocreatine and total creatine) for DAT+Sil rats, indicating a functional up-regulation of dorsal striatum (Str) and conversely a down-regulation of ventral striatum (i.e. nucleus accumbens, NAc).	Hydrogen	11-13	solute carrier family 6 member 3	Rattus norvegicus	160-163
9988688-4	1999	We show here that the addition of EF-1alpha and GTP in excess in the aminoacylation mixture is accompanied by a 2-fold stimulation of valyl-tRNAVal synthesis catalyzed by the valyl-tRNA synthetase component of the ValRS.EF-1H complex.	Hydrogen	223-225	valyl-tRNA synthetase 1	Homo sapiens	214-219
16913703-5	2006	The Lys89 residue in the ATP-binding pocket of CDK2 is observed to form temporary hydrogen bonds with the three most potent inhibitors.	Hydrogen	82-90	cyclin dependent kinase 2	Homo sapiens	47-51
20820552-3	2010	The results obtained in this work suggest that considerable differences in the NQR parameters permit differentiation even between specific pure association polymorphic forms and indicate that the stronger hydrogen bonds are accompanied by the larger eta and smaller nu(-) and e(2)Qq/h values.	Hydrogen	205-213	endothelin receptor type A	Homo sapiens	250-253
17168523-4	2006	Consistent with the CalC self-sacrifice mechanism, CLM in complex with CalC is positioned for direct hydrogen abstraction from Gly113 to initiate the oxidative proteolysis-based resistance mechanism.	Hydrogen	101-109	mitochondrial calcium uptake 1	Homo sapiens	20-24
17168523-4	2006	Consistent with the CalC self-sacrifice mechanism, CLM in complex with CalC is positioned for direct hydrogen abstraction from Gly113 to initiate the oxidative proteolysis-based resistance mechanism.	Hydrogen	101-109	mitochondrial calcium uptake 1	Homo sapiens	71-75
10050771-7	1999	In the 1H-NMR solution structures of single fibronectin type II domains, residues topologically equivalent to PDC-109 Arg57 (Arg104) and Lys59 lay around beta-strand D on the same face of the domain.	Hydrogen	7-9	seminal plasma protein PDC-109	Bos taurus	110-117
9878434-0	1999	Hydrogen exchange in ribonuclease A and ribonuclease S: evidence for residual structure in the unfolded state under native conditions.	Hydrogen	0-8	ribonuclease A family member 1, pancreatic	Homo sapiens	21-35
20472450-9	2010	According to the NMR results, it seems that the collision occurs between para-hydrogen of 2,6-DAP and fast neutrons.	Hydrogen	78-86	death associated protein	Homo sapiens	94-97
10927228-2	1999	Model X-ray data are computed from a superposition of ab initio molecular electron densities in the crystal, as well as from periodic crystal Hartree-Fock electron densities, for the hydrogen-bonded systems ice VIII, formamide and urea, as well as the weakly bound acetylene.	Hydrogen	183-191	cytochrome c oxidase subunit 8A	Homo sapiens	211-215
9838003-12	1998	We also find that many of the water-mediated hydrogen bonds between the a1 and alpha2 homeodomains and the DNA are highly conserved, indicating an important role for water in stabilization of the a1/alpha2-DNA complex.	Hydrogen	45-53	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	79-85
16784849-4	2006	The derivatives were also tested for their activities against another nuclear receptor, farnesoid x receptor (FXR), with most compounds acting as weak antagonists, however, compound 1h behaved as a FXR agonist with activity slightly less than that of chenodeoxycholic acid (CDCA), a natural FXR agonist.	Hydrogen	182-184	nuclear receptor subfamily 1 group H member 4	Homo sapiens	110-113
9838003-12	1998	We also find that many of the water-mediated hydrogen bonds between the a1 and alpha2 homeodomains and the DNA are highly conserved, indicating an important role for water in stabilization of the a1/alpha2-DNA complex.	Hydrogen	45-53	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	199-205
16784849-4	2006	The derivatives were also tested for their activities against another nuclear receptor, farnesoid x receptor (FXR), with most compounds acting as weak antagonists, however, compound 1h behaved as a FXR agonist with activity slightly less than that of chenodeoxycholic acid (CDCA), a natural FXR agonist.	Hydrogen	182-184	nuclear receptor subfamily 1 group H member 4	Homo sapiens	198-201
20639133-5	2010	Using hydrogen/deuterium exchange with mass spectrometry (HDMS), deamidation-induced local structural changes in betaB2-crystallin were identified.	Hydrogen	6-14	crystallin beta B2	Homo sapiens	113-130
16784849-4	2006	The derivatives were also tested for their activities against another nuclear receptor, farnesoid x receptor (FXR), with most compounds acting as weak antagonists, however, compound 1h behaved as a FXR agonist with activity slightly less than that of chenodeoxycholic acid (CDCA), a natural FXR agonist.	Hydrogen	182-184	nuclear receptor subfamily 1 group H member 4	Homo sapiens	198-201
9820830-5	1998	Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha).	Hydrogen	199-201	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	74-127
21105403-13	2010	Compared with those results, the action mode of ginsenoside Rb1 on DPPC bilayers may be because of hydrogen bonds that can be easily formed for the sugar moieties and the hydroxyls in Rb1 molecule.	Hydrogen	99-107	RB transcriptional corepressor 1	Homo sapiens	60-63
9874219-4	1998	The determination of the solution structure has been started with the assignment of 1H, 15N and 13C resonances of the oxidized rabbit uteroglobin, based on several two-dimensional and three-dimensional homonuclear and heteronuclear double and triple resonance experiments.	Hydrogen	84-86	uteroglobin	Oryctolagus cuniculus	134-145
16854127-3	2006	The proton exchange membrane (PEM) fuel cell employing the self-humidifying membrane (Pt-SiO2/NP) turns out a peak power density of 1.40 W cm(-2) and an open circuit voltage (OCV) of 1.032 V under dry H2/O2 condition.	Hydrogen	201-203	mucin 1, cell surface associated	Homo sapiens	30-33
16854128-4	2006	The hydrogen bonding on the surface of nanorods or nanostrips possibly plays a key role, as identified by FTIR spectra of the products after they had been heated to 1000 degrees C. The specific surface area and pore-size distribution of the obtained product as determined by gas-sorption measurements show that the boehmite nanoarchitectures exhibit high BET surface area and porosity properties.	Hydrogen	4-12	delta/notch like EGF repeat containing	Homo sapiens	355-358
16784750-9	2006	Only after the backbone hydrogen bonds are formed between beta1 and beta2 does a hydrogen bond form to stabilize the intervening turn, or the first beta-turn.	Hydrogen	24-32	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	68-73
16784750-9	2006	Only after the backbone hydrogen bonds are formed between beta1 and beta2 does a hydrogen bond form to stabilize the intervening turn, or the first beta-turn.	Hydrogen	81-89	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	68-73
21105403-13	2010	Compared with those results, the action mode of ginsenoside Rb1 on DPPC bilayers may be because of hydrogen bonds that can be easily formed for the sugar moieties and the hydroxyls in Rb1 molecule.	Hydrogen	99-107	RB transcriptional corepressor 1	Homo sapiens	184-187
20502928-8	2010	These findings are consistent with the presence of a hydrogen-bonding network at the heme"s distal side within the active site of HO-2 with potentially significant differences from that observed in HO-1.	Hydrogen	53-61	heme oxygenase 2	Homo sapiens	130-134
16834382-0	2006	Effect on kinetics by deuterium in the 1,5-hydrogen shift of a cisoid-locked 1,3(Z)-pentadiene, 2-methyl-10-methylenebicyclo[4.4.0]dec-1-ene: evidence for tunneling?	Hydrogen	43-51	deleted in esophageal cancer 1	Homo sapiens	131-136
20669983-4	2010	When MCF-7 cells were treated with the analogues, those resulting from hydrogen substitution by isopropyl (3d), isobutyl (3f), cyclopentyl (3g), and pyrano- (2) inhibited cell proliferation, estrogen-induced transcriptional activity, and estrogen receptor (ER) regulated progesterone receptor (PgR) gene expression.	Hydrogen	71-79	progesterone receptor	Homo sapiens	271-292
16771464-5	2006	The electrogenerated ArS(ArSSAr)+ was well-characterized by 1H NMR and CSI-MS.	Hydrogen	60-62	RIEG2	Homo sapiens	21-24
20669983-4	2010	When MCF-7 cells were treated with the analogues, those resulting from hydrogen substitution by isopropyl (3d), isobutyl (3f), cyclopentyl (3g), and pyrano- (2) inhibited cell proliferation, estrogen-induced transcriptional activity, and estrogen receptor (ER) regulated progesterone receptor (PgR) gene expression.	Hydrogen	71-79	progesterone receptor	Homo sapiens	294-297
16769893-7	2006	Furthermore, the ET rate from NADPH/CPR to the composite is 3.5-fold faster than that of Fe(Schiff-base).HO, although the redox potential of Fe(10-CH(2)CH(2)COOH-Schiff-base).HO (-79 mV vs. NHE) is lower than that of Fe(Schiff-base).HO (+15 mV vs. NHE), where NHE is normal hydrogen electrode.	Hydrogen	274-282	solute carrier family 9 member C1	Homo sapiens	190-193
20594838-4	2010	This study demonstrates that loss of binding in vancomycin resistant strains as a result of a d-Ala to d-Lac mutation is from both the loss of a crucial hydrogen bond and introduction of a repulsive lone pair interaction.	Hydrogen	153-161	lactase	Homo sapiens	105-108
20527969-4	2010	The X-ray cocrystal structure of 50 bound on PPARgamma revealed that the key hydrogen bond interactions, which are not related to the activation function 2 (AF-2) site, are different from those of the full agonist.	Hydrogen	77-85	peroxisome proliferator activated receptor gamma	Mus musculus	45-54
16749848-3	2006	In these compounds, LH2 refers to the tetraiminodiphenol macrocycle in the zwitterionic form whose two uncoordinated imine nitrogens are protonated and hydrogen-bonded to the metal-bound phenolate oxygens.	Hydrogen	152-160	LIM homeobox 2	Homo sapiens	20-23
20226840-6	2010	morphine or beta-endorphin began to increase within 30min and reached maximal level at 1h, decreasing to the basal level after 2h.	Hydrogen	87-89	pro-opiomelanocortin-alpha	Mus musculus	12-26
16722709-6	2006	The complex was found to have a strong hydrogen bond (D(e) = 43.9 kJ mol(-1)) with the hydrogen in HO2 binding to the oxygen in CH3OH.	Hydrogen	39-47	heme oxygenase 2	Homo sapiens	99-102
16722709-6	2006	The complex was found to have a strong hydrogen bond (D(e) = 43.9 kJ mol(-1)) with the hydrogen in HO2 binding to the oxygen in CH3OH.	Hydrogen	87-95	heme oxygenase 2	Homo sapiens	99-102
20882752-7	2010	Western blot analysis showed LDH1/LDH5 isoenzyme ratio in the astrocytes to be positively correlated with Neuro2A-derived lactate levels estimated by the amplitude of 1.33-ppm spectral peak in 1H-NMR, and LDH1/LDH5 isoenzyme ratio in neurons is negatively correlated with CSD1A-derived lactate levels.	Hydrogen	193-195	lactate dehydrogenase A	Mus musculus	29-33
16481104-6	2006	Short duration (1h) exposure of dissociated sensory neurons to NTFs increased numbers of TRPV1-positive neurons, but not of TRPV3, Nav 1.8 and IK1 and the morphological size-distribution remained similar to intact post-mortem DRG neurons.	Hydrogen	16-18	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-94
20405902-7	2010	The least favored structure, G-3, can be eliminated by annealing the matrix to 35 K. Addition of the first water molecule to G-1 takes place at the carboxylic acid group, with simultaneous hydrogen bonding of the water molecule to the carboxylic acid (C=)O and (O-)H. The results are consistent with the predominance of this structure, although there is evidence for a small amount of a hydrated G-2 structure.	Hydrogen	189-197	BAG cochaperone 6	Homo sapiens	29-32
16697681-8	2006	As early as 1h postinfection, three genes, (IEX-1, IRF-1, DEC-1) all implicated in apoptosis pathways, were upregulated.	Hydrogen	12-14	deleted in esophageal cancer 1	Homo sapiens	58-63
20203135-2	2010	In the present study, neutral-pH hydrogen-enriched electrolyzed water (NHE-water; dissolved hydrogen: 0.90-1.14 parts per million [ppm]; oxido-reduced potential: -150 approximately -80 mV), which was prepared with a water-electrolysis apparatus equipped with a non-diaphragm cell and a highly compressed activated-carbon block, was evaluated for the mutagenic and genotoxic potentials, at concentrations up to 100% dose/plate, and for the subchronic toxicity.	Hydrogen	33-41	solute carrier family 9 member C1	Homo sapiens	71-74
16530222-7	2006	Analysis of the YTS 105.18 Fab epitope on CD8alpha reveals that this antibody blocks CD8 activity by hydrogen bonding to residues that are critical for interaction with both class I pMHC and TL.	Hydrogen	101-109	CD8 antigen, alpha chain	Mus musculus	42-50
20229545-0	2010	Production of HCOOH/NEt3 adducts by CO2/H2 incorporation into neat NEt3.	Hydrogen	40-42	tetraspanin 2	Homo sapiens	20-24
16487539-3	2006	A slow, partial unfolding event that occurs under physiological conditions was previously identified in the Hck SH3 domain using hydrogen exchange (HX) mass spectrometry (MS).	Hydrogen	129-137	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	108-111
20229545-0	2010	Production of HCOOH/NEt3 adducts by CO2/H2 incorporation into neat NEt3.	Hydrogen	40-42	tetraspanin 2	Homo sapiens	67-71
20366487-0	2010	Exceptionally strong hydrogen bonds affect the surface energy of colloidal nanocrystals: methylamine and water adsorption on PbS.	Hydrogen	21-29	cholinergic receptor muscarinic 3	Homo sapiens	125-128
16562948-8	2006	Notably, the structure with alpha-D-Fru-1,6-P2 demonstrated the presence of a strong hydrogen bond between the C2 hydroxyl group and the C1 phosphate oxygen atom, which may support the previously proposed catalytic mechanism in the active site of fructose-1,6-bisphosphatase.	Hydrogen	85-93	zinc finger and BTB domain containing 22	Homo sapiens	36-39
20036143-3	2010	A time response study demonstrated that the activity and protein expression of the ATPase are decreased at 1h and increased at 4, 6 and 8h.	Hydrogen	107-109	dynein axonemal heavy chain 8	Homo sapiens	83-89
16518493-1	2006	Crystallization studies of C-methyl pyrogallarene with potassium, rubidium and caesium bromides or chlorides resulted in a hydrogen bonded molecular cage in which the alkali metal cations are eta6 coordinated to aromatic rings via strong cation-pi interactions.	Hydrogen	123-131	endothelin receptor type A	Homo sapiens	175-178
19686765-6	2010	First, the XPC subunit uses a dynamic sensor interface to monitor the double helix for the presence of non-hydrogen-bonded bases.	Hydrogen	107-115	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	11-14
16526652-0	2006	Exploration of the potential energy surfaces, prediction of atmospheric concentrations, and prediction of vibrational spectra for the HO2...(H2O)n (n = 1-2) hydrogen bonded complexes.	Hydrogen	157-165	heme oxygenase 2	Homo sapiens	134-137
19876967-5	2010	In the acyclic beta(2, 3)-aminoxy peptides with an anti configuration, an extended strand (i.e., non-hydrogen-bonded state) is found in the solid state, and several conformations including non-hydrogen-bonded and intramolecular hydrogen-bonded states are present simultaneously in nonpolar solvents.	Hydrogen	101-109	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	15-24
16509743-4	2006	These conformers as well as syn conformers of pdG are stabilized by intramolecular N-H...O hydrogen bonds.	Hydrogen	91-99	phosphoglycerate dehydrogenase	Homo sapiens	46-49
19876967-5	2010	In the acyclic beta(2, 3)-aminoxy peptides with an anti configuration, an extended strand (i.e., non-hydrogen-bonded state) is found in the solid state, and several conformations including non-hydrogen-bonded and intramolecular hydrogen-bonded states are present simultaneously in nonpolar solvents.	Hydrogen	193-201	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	15-24
19876967-5	2010	In the acyclic beta(2, 3)-aminoxy peptides with an anti configuration, an extended strand (i.e., non-hydrogen-bonded state) is found in the solid state, and several conformations including non-hydrogen-bonded and intramolecular hydrogen-bonded states are present simultaneously in nonpolar solvents.	Hydrogen	193-201	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	15-24
16489751-14	2006	Although the structure of Cdc42Hs(F28L)-GDP is very similar to that of the wild type, interactions with the nucleotide and hydrogen bonding within the nucleotide binding site are altered, and the region surrounding L28 is substantially more disordered.	Hydrogen	123-131	cell division cycle 42	Homo sapiens	26-33
20460771-6	2010	Molecular docking studies of mefenamic acid and glycyrrhetic acid in the AKR1B10-nicotinamide adenine dinucleotide phosphate (NADP(+)) complex and site-directed mutagenesis of the putative binding residues suggest that the side chain of Val301 and a hydrogen-bonding network among residues Val301, Gln114 and Ser304 are important for determining the inhibitory potency and selectivity of the non-steroidal antiinflammatory drugs.	Hydrogen	250-258	aldo-keto reductase family 1 member B10	Homo sapiens	73-80
19918833-6	2010	Molecular modeling studies based on the X-ray crystal structures of both human caspases 3 and 8 revealed that there is sufficient room within both active sites to accommodate substrates with moderately bulky substituents in the 3- and 4-positions of the fluorogenic coumarins and quinolin-2(1H)-ones.	Hydrogen	291-293	caspase 8	Homo sapiens	79-87
9990536-1	1998	1H NMR has now detected the proximal histidyl N delta H myoglobin (Mb) signal from the myocardium in situ.	Hydrogen	0-2	myoglobin	Rattus norvegicus	56-65
9841653-1	1998	Maple tree sap is a source of environmental sugar (e.g., sucrose) that has the potential to be converted into hydrogen using the enzymes invertase, glucose dehydrogenase (GDH), hydrogenase, and glucose isomerase (GI) and the cofactor NADP+/NADPH. The kinetics of hydrogen production have been studied, and optimal conditions for hydrogen production are described.	Hydrogen	111-119	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	149-170
19674817-7	2009	All except E6, E11 and P6 showed more than 50% decrease in locomotor activity at 1h of compound administration via actophotometer screen.	Hydrogen	81-83	exosome component 9	Mus musculus	11-25
9841653-1	1998	Maple tree sap is a source of environmental sugar (e.g., sucrose) that has the potential to be converted into hydrogen using the enzymes invertase, glucose dehydrogenase (GDH), hydrogenase, and glucose isomerase (GI) and the cofactor NADP+/NADPH. The kinetics of hydrogen production have been studied, and optimal conditions for hydrogen production are described.	Hydrogen	111-119	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	172-175
9760238-8	1998	A 1H,15N-NOESY-HSQC spectrum demonstrated that the binding surface on Cdc42Hs consists of the second beta-strand (beta2) and a portion of the loop between the first alpha-helix (alpha1) and beta2 (switch I).	Hydrogen	2-4	cell division cycle 42	Homo sapiens	70-77
9760238-8	1998	A 1H,15N-NOESY-HSQC spectrum demonstrated that the binding surface on Cdc42Hs consists of the second beta-strand (beta2) and a portion of the loop between the first alpha-helix (alpha1) and beta2 (switch I).	Hydrogen	2-4	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	114-119
19701937-12	2009	It is suggested that hydrogen-bonding interactions play a key role in the DNA recognition mechanisms of the designed ZFP.	Hydrogen	21-29	zinc finger with KRAB and SCAN domains 7	Homo sapiens	117-120
9760238-9	1998	A complex of PBD46 bound to 15N-Cdc42Hs.GMPPCP exhibited extensive chemical shift changes in the 1H,15N-HSQC spectrum.	Hydrogen	97-99	cell division cycle 42	Homo sapiens	32-39
9731751-3	1998	One of the mechanisms by which intracellular pH (pHi) is regulated is through the sodium/hydrogen exchanger, a ubiquitous membrane protein which exploits the intra- and extracellular sodium ion gradient to drive hydrogen ions out of the cell.	Hydrogen	89-97	glucose-6-phosphate isomerase 1	Mus musculus	49-52
9731751-3	1998	One of the mechanisms by which intracellular pH (pHi) is regulated is through the sodium/hydrogen exchanger, a ubiquitous membrane protein which exploits the intra- and extracellular sodium ion gradient to drive hydrogen ions out of the cell.	Hydrogen	212-220	glucose-6-phosphate isomerase 1	Mus musculus	49-52
19812844-7	2009	In contrast, E(ad) increases from -0.30 to -0.20 eV/H2 when F = -0.010 au.	Hydrogen	52-54	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	13-18
9789333-1	1998	The hydrogen (H2) clearance method was adapted for the measurement of regional cerebral blood flow (rCBF) in anesthetized rats and mice during hyperbaric oxygen (HBO2) exposure.	Hydrogen	4-12	CCAAT/enhancer binding protein zeta	Rattus norvegicus	100-104
9789333-1	1998	The hydrogen (H2) clearance method was adapted for the measurement of regional cerebral blood flow (rCBF) in anesthetized rats and mice during hyperbaric oxygen (HBO2) exposure.	Hydrogen	14-16	CCAAT/enhancer binding protein zeta	Rattus norvegicus	100-104
9789333-4	1998	The rCBF values (measured every 10 min) were calculated from the H2 clearance curves using the initial slope method.	Hydrogen	65-67	CCAAT/enhancer binding protein zeta	Rattus norvegicus	4-8
9789333-11	1998	The H2 clearance method seems to be an accurate and sensitive technique for the repeated measurement of local CBF under hyperbaric conditions.	Hydrogen	4-6	CCAAT/enhancer binding protein zeta	Rattus norvegicus	110-113
19905708-1	2009	We present incoherent quasielastic neutron scattering measurements on ice Ih (ordinary ice) and Ic (cubic ice) which show the existence of nonharmonic motion of hydrogen at low temperatures, down to 5 K. We show that this dynamics is localized, nonvibrational, and related to the hydrogen disorder since it is absent in ordered ice VIII.	Hydrogen	161-169	cytochrome c oxidase subunit 8A	Homo sapiens	332-336
9742944-1	1998	1H NMR proximal histidyl NdeltaH signals of deoxy hemoglobin (Hb) and myoglobin (Mb) are distinguishable in the rat myocardium in situ.	Hydrogen	0-2	myoglobin	Rattus norvegicus	70-79
9742944-1	1998	1H NMR proximal histidyl NdeltaH signals of deoxy hemoglobin (Hb) and myoglobin (Mb) are distinguishable in the rat myocardium in situ.	Hydrogen	0-2	myoglobin	Rattus norvegicus	81-83
19739677-1	2009	Here we present the use of hydrogen-deuterium exchange (HDX) mass spectrometry in analyzing the estrogen receptor beta ligand binding domain (ERbeta LBD) in the absence and presence of a variety of chemical compounds with different binding modes and pharmacological properties.	Hydrogen	27-35	estrogen receptor 2	Homo sapiens	142-148
9796820-1	1998	Additional interactions possibly involving the well-exposed H2 helical domain of hTBP and the acidic fragment L(281-301) of the non-conserved domain of hTFIIA have been proposed to account for the apparent discrepancies between the results of mutagenesis experiments on human proteins and the structure of the ternary complex TBP/TATA box/TFIIA established from yeast proteins by X-ray crystallography.	Hydrogen	60-62	general transcription factor IIA subunit 1	Homo sapiens	152-158
9796820-1	1998	Additional interactions possibly involving the well-exposed H2 helical domain of hTBP and the acidic fragment L(281-301) of the non-conserved domain of hTFIIA have been proposed to account for the apparent discrepancies between the results of mutagenesis experiments on human proteins and the structure of the ternary complex TBP/TATA box/TFIIA established from yeast proteins by X-ray crystallography.	Hydrogen	60-62	general transcription factor IIA subunit 1	Homo sapiens	153-158
9796820-5	1998	Molecular modelling studies indicate that this complex could be stabilized by electrostatic interactions involving the glutamate Glu287 and aspartates (Asp290, Asp294, Asp297 and Asp298) of L(281-301)TFIIA and lysine residues (Lys133, Lys138 and Lys145) and arginine residues (Arg137, Arg140) of H2(TBP) in agreement with mutagenesis experiments.	Hydrogen	296-298	general transcription factor IIA subunit 1	Homo sapiens	200-205
21577964-3	2009	The mol-ecular structure features close intra-molecular C-H N and C-H O hydrogen bonding.	Hydrogen	72-80	chimerin 1	Homo sapiens	56-69
9817581-8	1998	Consistent with previous reports, HS-treated rats consumed significantly more milk than control rats from postnatal Day 4 (P4) through P11 but consumed significantly less milk than controls at P19.	Hydrogen	34-36	S100 calcium binding protein A10	Rattus norvegicus	135-138
9650600-8	1998	Single-slice (5-6 mm thick) localized 1H spectra of subcutaneous RIF-1 (untreated) and EMT6 tumors (pretreatment, 24 and 48 h postirradiation with 4, 10 or 20 Gy of gamma radiation) were measured by the selective multiple quantum coherence transfer method (Sel-MQC, approximately 4 min acquisition time).	Hydrogen	38-40	replication timing regulatory factor 1	Homo sapiens	65-70
19739845-7	2009	Our new SSB-D functional is found to be a clear improvement and functions very well for biological applications (hydrogen bonding, pi-pi stacking, spin-state splittings, accuracy of geometries, reaction barriers).	Hydrogen	113-121	small RNA binding exonuclease protection factor La	Homo sapiens	8-11
9601071-6	1998	However, in cross-linking and competition studies the H2 analogue exhibited an affinity for insulin-degrading enzyme identical with that of wild-type insulin.	Hydrogen	54-56	insulin degrading enzyme	Rattus norvegicus	92-116
9554882-2	1998	1H NMR chemical shift assignments for the mammalian NK1 receptor-selective agonists alpha-neurokinin (NKA) and beta-neurokinin (NKB) as well as the mammalian NK1 receptor-selective antagonists [d-Pro2,d-Phe7,d-Trp9]SP and [d-Arg1, d-Pro2,d-Phe7,d-His9]SP have been determined at 600 MHz in sodium dodecyl sulfate (SDS) micelles.	Hydrogen	0-2	arginase 1	Homo sapiens	225-229
19702527-7	2009	Typical substrates of CYP2B6 are non-planar molecules, neutral or weakly basic, highly lipophilic with one or two hydrogen-bond acceptors.	Hydrogen	114-122	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	22-28
19486995-4	2009	The analysis of (1)H NMR chemical shift measurements proved that the higher solvophilicity of the surfactants in bmimPF(6) is attributed to weaker hydrogen-bond interaction between bmim cation and PF6- anion than that between bmim cation and BF4- anion.	Hydrogen	147-155	sperm associated antigen 17	Homo sapiens	197-200
9563511-3	1998	In the present study, the 3-D model of A55T human plasmin shows that an unusual hydrogen bond between Thr55 Ogamma1 and His57 Nepsilon2 alters His57 into an inactive conformation in which His57 cannot accept a proton from Ser195 as a catalytic base.	Hydrogen	80-88	plasminogen	Homo sapiens	50-57
9488681-5	1998	The major determinant for discrimination of cGMP over cAMP is in the N-1/C-6 region of the purine ring of cGMP where hydrogen bonding probably stabilizes the selective binding of cGMP.	Hydrogen	117-125	complement C6	Homo sapiens	73-76
9488681-7	1998	The unaltered hydrogen at the C-8 position is also important for high affinity binding.	Hydrogen	14-22	homeobox C8	Homo sapiens	30-33
19609301-3	2009	Bidirectional truncation analyses disclosed a surprisingly short recognition hotspot, comprising approximately 15% of human XPC, that includes two beta-hairpin domains with a preference for non-hydrogen-bonded bases in double-stranded DNA.	Hydrogen	194-202	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	124-127
18967059-6	1998	It was observed that SnO(2) with higher surface areas had much higher sensitivities to hydrogen at 573 K.	Hydrogen	87-95	strawberry notch homolog 1	Homo sapiens	21-24
19678985-6	2009	There is an increase in the amount of hydrogen-bonded carboxyl groups in mucin deposited at a pH of 3.	Hydrogen	38-46	mucin 1, cell surface associated	Bos taurus	73-78
9923695-0	1998	Sequence-specific 1H NMR resonance assignments and secondary structure of human apolipoprotein C-I in the presence of sodium dodecyl sulfate.	Hydrogen	18-20	apolipoprotein C1	Homo sapiens	80-98
19298826-4	2009	Changes in the rate of hydrogen exchange indicate that ATP binding causes conformational rearrangements of Arp2 and Arp3 that are transmitted allosterically to the Arp complex (ARPC)1, ARPC2, ARPC4, and ARPC5 subunits.	Hydrogen	23-31	actin related protein 2/3 complex subunit 5	Homo sapiens	203-208
9395093-3	1997	Deuterium exchange NMR experiments of Zn(II)-GAL4(7-49) indicate that the binuclear metal ion structure, which is shown to have a net negative charge of -2, is the recipient of several hydrogen bonds, notably from the main-chain amide protons of the ligating cysteine residues, indicating the charge is stabilised in this manner.	Hydrogen	185-193	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	38-49
16651846-7	2006	Large neointimas of the HS group contained vimentin-positive and largely desmin- and h-caldesmon-negative cells.	Hydrogen	24-26	vimentin	Oryctolagus cuniculus	43-51
19540766-5	2009	Docking studies revealed that the free amino groups of the most active compounds are within hydrogen bonding distance of His-119 in inhibitor-RNase A complexes.	Hydrogen	92-100	ribonuclease A family member 1, pancreatic	Homo sapiens	142-149
16939084-2	2006	The controller is based on the indirect control of COD in the effluent by means of controlling the hydrogen concentration in the biogas.	Hydrogen	99-107	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	51-54
16363814-7	2005	Our findings can be understood in terms of a hydrogen bond formed within the phosphomonoester headgroup of (L)PA and its destabilization by competing intra- or intermolecular hydrogen bonds.	Hydrogen	45-53	lipoprotein(a)	Homo sapiens	108-112
16363814-7	2005	Our findings can be understood in terms of a hydrogen bond formed within the phosphomonoester headgroup of (L)PA and its destabilization by competing intra- or intermolecular hydrogen bonds.	Hydrogen	175-183	lipoprotein(a)	Homo sapiens	108-112
9367761-4	1997	Unlike other (beta alpha)8-barrels, the barrel in PI-PLC is open because it lacks hydrogen bonding interactions between beta-strands V and VI.	Hydrogen	82-90	phospholipase C beta 1	Homo sapiens	50-56
9390409-0	1997	Assignment of the 1H, 15N and 13C resonances of the calcium-free and calcium-bound forms of the first C2-domain of synaptotagmin I.	Hydrogen	18-20	synaptotagmin 1	Homo sapiens	115-130
16363814-8	2005	We propose that this hydrogen bonding property of (L)PA is involved in the various cellular functions of these lipids.	Hydrogen	21-29	lipoprotein(a)	Homo sapiens	51-55
19037860-6	2009	The PL component was characterized through a new measure of the local molecular hardness at hydrogen, eta(H), which in turn was quantified through empirically defined site-specific effective donor and acceptor energies, EE(occ) and EE(vac).	Hydrogen	92-100	endothelin receptor type A	Homo sapiens	102-105
16375482-0	2005	(HCl)2 and (HF)2 in small helium clusters: quantum solvation of hydrogen-bonded dimers.	Hydrogen	64-72	HCL2	Homo sapiens	1-6
9260280-7	1997	The analysis leads to the conclusion that the difference in thermal stability between RNase A and (N67isoD)RNase A is due to enthalpic effects arising from the loss of two important hydrogen bonds in the loop containing residue 67, partially counterbalanced by entropic effects.	Hydrogen	182-190	ribonuclease A family member 1, pancreatic	Homo sapiens	86-93
9260280-7	1997	The analysis leads to the conclusion that the difference in thermal stability between RNase A and (N67isoD)RNase A is due to enthalpic effects arising from the loss of two important hydrogen bonds in the loop containing residue 67, partially counterbalanced by entropic effects.	Hydrogen	182-190	ribonuclease A family member 1, pancreatic	Homo sapiens	107-114
19168263-4	2009	This study suggests that affinity is closely related to the interactions of the boron atom, as well as the capacity of boronic acid moieties to make a network of hydrogen bonds with the beta(2)AR.	Hydrogen	162-170	beta-2 adrenergic receptor	Cavia porcellus	186-195
9219524-0	1997	A determination of the solution conformation of secretoneurin, a neuropeptide originating from the processing of secretogranin II, by 1H-NMR and restrained molecular dynamics.	Hydrogen	134-136	secretogranin II	Homo sapiens	48-61
16292818-3	2005	Cyclic voltammetry with Ru(NH3)6(3+/2+) as a redox probe, together with impedance spectroscopy and reductive desorption, indicates that SAMs of 5 have a higher coverage than those of 3 and 4 due to the presence of hydrogen bonding and possibly its conformation.	Hydrogen	214-222	methionine adenosyltransferase 1A	Homo sapiens	136-140
9219524-3	1997	In the present study, we have investigated the conformation of synthetic secretoneurin in methanol solution by two-dimensional 1H-NMR, circular dichroism and molecular modeling.	Hydrogen	127-129	secretogranin II	Homo sapiens	73-86
19523119-4	2009	By bioinformatics predictions, CD spectroscopy, wide-line and 1H-NMR spectroscopy, limited proteolysis and gel filtration chromatography, we provided evidence that the entire proline-rich region of CASK-interactive protein1 is intrinsically disordered.	Hydrogen	62-64	calcium/calmodulin dependent serine protein kinase	Homo sapiens	198-202
9199408-7	1997	The three-dimensional structure of TFPI-kII in aqueous solution was determined by 1H nuclear magnetic resonance spectroscopy (NMR).	Hydrogen	82-84	tissue factor pathway inhibitor	Homo sapiens	35-39
9184143-9	1997	The 15N-1H HSQC NMR spectrum of WT PI-PLC is also reported at 600 MHz.	Hydrogen	8-10	phospholipase C beta 1	Homo sapiens	35-41
19505100-6	2009	Because similar hydrogen-bonding networks have also been suggested by structural analysis of two other GPCRs, beta1 and beta2 adrenergic receptors, our results could reveal a general role of hydrogen bonds in facilitating GPCR function.	Hydrogen	16-24	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	120-125
16246032-7	2005	Evolutionary conservation of the energetically coupled residues in a manner that preserves their ability to form a hydrogen bond argues that this molecular mechanism, involving dynamic restructuring of the NBD dimer interface, is shared by all members of the ABC protein superfamily.	Hydrogen	115-123	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	259-262
19505100-6	2009	Because similar hydrogen-bonding networks have also been suggested by structural analysis of two other GPCRs, beta1 and beta2 adrenergic receptors, our results could reveal a general role of hydrogen bonds in facilitating GPCR function.	Hydrogen	191-199	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	120-125
21977281-9	2009	Matrix-metalloproteinase-2 plasma activity increased progressively starting 1h after cardiopulmonarybypass and returned to pre-operative levels at 24h.	Hydrogen	76-78	matrix metallopeptidase 2	Homo sapiens	0-26
16201826-6	2005	In particular, DFT calculations demonstrate that a normal kinetic isotope effect requires thiolate dissociation because it results in the formation of [PhN(H)C(O)CH2S]- which, as an anion, exhibits a stronger N-H...S hydrogen bonding interaction than that in [Tm(Ph)]ZnSCH2C(O)N(H)Ph.	Hydrogen	217-225	carbamoyl-phosphate synthase 1	Homo sapiens	152-155
9145390-5	1997	The prediction model for the DB-1 column includes descriptors such as Randic"s first-order connectivity index (1X), the molecular surface (MSA), the sum of the atomic charge on all the hydrogens (QH), Randic"s third-order connectivity index (3X) and the molecular electronegativity (chi).	Hydrogen	185-194	vascular endothelial zinc finger 1	Homo sapiens	29-33
9083477-4	1997	Thirdly, compounds with hydrogen bond-accepting or-donating groups attached to the phenyl groups in the P2 and P2" side chains (6 and 7) were selected.	Hydrogen	24-32	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	104-113
19415917-10	2009	Specifically, extensive hydrogen-bonded network involving termini hydroxyls of PEGs and PF6- as well as ethoxy/hydroxyl oxygens of PEGs and the C2-H of bmim+ is proposed to be responsible for the unusual outcomes.	Hydrogen	24-32	sperm associated antigen 17	Homo sapiens	88-91
9056693-1	1997	The study was undertaken to determine the possible effect of an aldosterone antagonist, spironolactone (SP), on red blood cell sodium-hydrogen exchange (NHE) enhancement in primary aldosteronism (PA) and essential hypertension (EH).	Hydrogen	134-142	solute carrier family 9 member C1	Homo sapiens	153-156
16209509-1	2005	[structure: see text] Cyclic tetrapeptides in which alpha-amino acids alternate with cis-3-aminocycloalkanecarboxylic acids dimerize by forming hydrogen bonds between their alpha-faces but not between their gamma-faces, establishing the minimal structural requirements for the novel alpha,gamma-peptide hybrids SPN.	Hydrogen	144-152	suppressor of cytokine signaling 3	Homo sapiens	85-90
16853448-3	2005	Analysis of mixtures of [C6mim]Cl and [C6mim][PF6] has provided information on the nature of the hydrogen bonding between the imidazolium headgroup and the anions, and the invariance of the essentially 50:50 mixture of the predominant conformers informs on the nature of glass formation in these systems.	Hydrogen	97-105	sperm associated antigen 17	Homo sapiens	46-49
21583098-3	2009	In the crystal, weak inter-molecular C-H S and C-H O hydrogen bonds link the mol-ecules into chains propagating along [010].	Hydrogen	53-61	lysosomal trafficking regulator	Homo sapiens	37-50
16161999-2	2005	The design of the I45DCs was based in part on the structures of trisubstituted purines complexed with cyclin dependent kinase 2 (cdk2), a protein important in regulating the G1/S transition in the cell cycle, and the intramolecular hydrogen bond in I45DCs that predisposes the conformation to one that mimics substituted adenosines.	Hydrogen	232-240	cyclin dependent kinase 2	Homo sapiens	129-133
16161999-4	2005	The SAR of the I45DCs is consistent with anticipated hydrogen bonding interactions in the ATP-binding site of cdk2.	Hydrogen	53-61	cyclin dependent kinase 2	Homo sapiens	110-114
9090718-1	1997	We conclude that TRH and its analogues permeate mainly via paracellular routes in this particular clone of Caco-2 cells because variation in lipophilicity, polar surface properties, or hydrogen bonding potential-all influencing the transcellular pathway-do not give meaningful relationships.	Hydrogen	185-193	thyrotropin releasing hormone	Homo sapiens	17-20
9016557-1	1997	We describe a novel activity of the SV40 large T-ag helicase, the unwinding of four stranded DNA structures linked by stacked G-quartets, namely stacked groups of four guanine bases bound by Hoogsteen hydrogen bonds.	Hydrogen	201-209	helicase for meiosis 1	Homo sapiens	52-60
19233899-4	2009	These kinetic properties of compounds 1 and 7 against TK-2 could be accounted for by molecular modeling showing that two hydrogen bonds can be formed between the thiourea nitrogens of compound 7 and the oxygens of the gamma-phosphate of ATP.	Hydrogen	121-129	thymidine kinase 2	Homo sapiens	54-58
9007990-0	1997	Heteronuclear (1H, 13C, 15N) NMR assignments and secondary structure of the basic region-helix-loop-helix domain of E47.	Hydrogen	15-17	transcription factor 3	Homo sapiens	116-119
9007990-9	1997	The HLH region of E47 is structured, but highly dynamic as judged by the rapid exchange of backbone hydrogen atoms and the relatively weak intensities of many of the NOEs defining the dimerization helices.	Hydrogen	100-108	transcription factor 3	Homo sapiens	18-21
15772084-11	2005	A spontaneous reversible unzipping of hydrogen bonds between beta4 and beta2 was observed, suggesting an early intermediate structure for unfolding and/or domain swapping.	Hydrogen	38-46	tubulin beta 3 class III	Homo sapiens	61-66
15772084-11	2005	A spontaneous reversible unzipping of hydrogen bonds between beta4 and beta2 was observed, suggesting an early intermediate structure for unfolding and/or domain swapping.	Hydrogen	38-46	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	71-76
8946804-6	1996	The conformation is stabilized by intramolecular hydrogen bonds involving Boc CO and NH of delta Phe3 and CO of Val1 and NH of Val4.	Hydrogen	49-57	dihydrolipoamide dehydrogenase	Homo sapiens	97-101
19405592-3	2009	A third mechanism, the almost thermoneutral abstraction of a hydrogen atom from methanol parent molecule by the photolytically produced hydrogen atom, yields translationally and rotationally cold H(2)(v=0 and 1) products.	Hydrogen	61-69	immunoglobulin kappa variable 1-5	Homo sapiens	201-210
8946804-9	1996	The solvent-water molecule forms two hydrogen bonds with peptide molecule involving NH of Val1 as an acceptor and another with CO of a symmetry related (1-x, y-1/2, 1/2 -z) delta Phe3 as a donor.	Hydrogen	37-45	dihydrolipoamide dehydrogenase	Homo sapiens	179-183
8849690-5	1996	The homologous polypeptide fragment of about 90 amino acids is also recovered in the NH2-terminal extension of human valyl-tRNA synthetase, involved in its assembly with EF-1H.	Hydrogen	173-175	valyl-tRNA synthetase 1	Homo sapiens	117-138
8756328-4	1996	The arginines help extend the influence of the phosphate group through a network of hydrogen bonds to both CDK2 and cyclinA.	Hydrogen	84-92	cyclin dependent kinase 2	Homo sapiens	107-111
16104729-0	2005	Ruthenium-catalyzed cycloisomerization of cis-3-en-1-ynes to cyclopentadiene and related derivatives through a 1,5-sigmatropic hydrogen shift of ruthenium-vinylidene intermediates.	Hydrogen	127-135	suppressor of cytokine signaling 3	Homo sapiens	42-47
16011353-5	2005	The position of the equilibrium reflects the propensity of the first (AA1) and fifth (AA5) amino acids to interact within the non-hydrogen-bonded cross-strand pairs of beta-sheets.	Hydrogen	130-138	AA1	Homo sapiens	70-73
19405592-3	2009	A third mechanism, the almost thermoneutral abstraction of a hydrogen atom from methanol parent molecule by the photolytically produced hydrogen atom, yields translationally and rotationally cold H(2)(v=0 and 1) products.	Hydrogen	136-144	immunoglobulin kappa variable 1-5	Homo sapiens	201-210
19319397-4	2009	Upon treatment with PI3 in CH2Cl2 solution, ligands 5-8 undergo redox reactions to furnish the triiodide salts of the corresponding phosphenium cations 13-16 which were characterized by 1H, 13C and 31P NMR, and MS-CI spectroscopy.	Hydrogen	186-188	peptidase inhibitor 3	Homo sapiens	20-23
15972253-8	2005	We suggest that electrons might be transferred to NapA either from menaquinol via NapC, or from other electron donors such as formate or hydrogen via the small tetraheme cytochrome, NapM.	Hydrogen	137-145	NSF attachment protein alpha	Homo sapiens	50-54
8692686-8	1996	By analogy with the rat pol beta structure, it is suggested that each of these HhH motifs bind DNA in a non-sequence-specific manner, via the formation of hydrogen bonds between protein backbone nitrogens and DNA phosphate groups.	Hydrogen	155-163	DNA polymerase beta	Rattus norvegicus	24-32
19507591-1	2009	OBJECTIVE: To investigate the value of in vivo proton magnetic resonance spectroscopy (1H MRS) in the assessment of hepatocellular carcinoma (HCC) and cholangiocarcinoma.	Hydrogen	87-89	HCC	Homo sapiens	142-145
8613464-12	1996	The association of p36 with the mitochondrial isoenzyme may favor the flow of hydrogen from the cytosol into the mitochondria.	Hydrogen	78-86	5'-nucleotidase, cytosolic IIIA	Homo sapiens	19-22
15984843-3	2005	The reaction of 1-Cp* with 8 at -60 degrees C in CDCl3 solution led to observation of the eta6-dienyne complex, (eta5-C5Me5)Ru[eta6-(1-isopropenyl-2-pent-1-ynylcyclopentene)]PF6 (10), by 1H NMR spectroscopy.	Hydrogen	187-189	sperm associated antigen 17	Homo sapiens	174-177
16132836-0	2005	1H, 13C and 15N backbone resonance assignment of the Hsp90 binding domain of human Cdc37.	Hydrogen	0-2	cell division cycle 37, HSP90 cochaperone	Homo sapiens	83-88
8999463-1	1996	2-chlorodeoxyadenosine (2-CdA) is a simple nucleoside derived from deoxyadenosine by substituting chloride for hydrogen in 2" position of the purine ring, which renders it resistant to degradation by adenosine deaminase.	Hydrogen	111-119	cytidine deaminase	Homo sapiens	26-29
19507591-2	2009	METHODS: 1H MRS was performed in normal volunteers and in patients with pathologically confirmed HCC and cholangiocarcinomas using a whole-body 1.5-T scanner.	Hydrogen	9-11	HCC	Homo sapiens	97-100
15845357-9	2005	Although the overall structures of the three enzymes are quite similar to each other, some subtle difference around their active sites that distinguishes cathepsin-E from cathepsin-D and BACE1 has been revealed through an analysis of hydrogen bond network and microenvironment.	Hydrogen	234-242	cathepsin D	Homo sapiens	171-182
19507591-7	2009	CONCLUSION: In vivo 1H MRS can reflect the pathological changes of HCC and cholangiocarcinomas at metabolic level and thus is useful in the diagnosis of these two cancers.	Hydrogen	20-22	HCC	Homo sapiens	67-70
19176520-0	2009	Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase.	Hydrogen	56-64	glutaredoxin	Homo sapiens	40-52
16161584-2	2005	The hydrogen interchange tunneling is basically quenched in (4, 0) for both K = 0 and 1 levels, consistent with the early suggestion from a phenomenological model [H.-C. Chang and W. Klemperer, J. Chem.	Hydrogen	4-12	keratin 1	Homo sapiens	76-87
8554577-2	1995	A monomeric analogue of phospholamban PLN(C41F), in which Cys41 was replaced by a Phe, was synthesized and its conformation studied by 1H NMR spectroscopy in a 1:1 mixture of chloroform/methanol.	Hydrogen	135-137	phospholamban	Homo sapiens	38-41
15918699-6	2005	The determined structure is planar and almost T shaped, where the argon atom is slightly shifted to the hydrogen atom of HO2.	Hydrogen	104-112	heme oxygenase 2	Homo sapiens	121-124
19220039-6	2009	Whereas the hydrogen abstraction reaction producing S + HO2 is found to proceed on the quartet surface, the substantial barrier of approximately 165 kJ mol-1 means that it occurs as a minor product channel.	Hydrogen	12-20	heme oxygenase 2	Homo sapiens	56-59
15853304-1	2005	A novel two-dimensional NMR pulse sequence, H2BC, for long-range correlation of 1H and 13C nuclei is presented.	Hydrogen	80-82	H2B clustered histone 13	Homo sapiens	44-48
7500338-8	1995	The [GGA]2 unit contains a stack of four contiguous guanine residues, all of which have their hydrogen-bonding surface (N2H-N1H-O6-N7) exposed to solvent and available for interaction with other bases or ligands.	Hydrogen	94-102	golgi associated, gamma adaptin ear containing, ARF binding protein 2	Homo sapiens	5-10
8807817-5	1995	RESULTS: The two tryptophan-derived Ah receptor ligands have been chemically analyzed and characterized by means of mass spectrometry, 1H NMR and 13C NMR.	Hydrogen	135-137	aryl hydrocarbon receptor	Homo sapiens	36-47
19109523-1	2009	NHE8 transporter is a member of the sodium/hydrogen exchanger (NHE) family.	Hydrogen	43-51	solute carrier family 9 member C1	Homo sapiens	0-3
8689949-5	1995	Pig liver FMO1 apparently only catalyzes C-oxidation of reactive aldehydes with a hydrogen ion acceptor function adjacent to the carbonyl.	Hydrogen	82-90	flavin containing dimethylaniline monoxygenase 1	Sus scrofa	10-14
15681132-7	2005	The sensitivity of eta((23)Na) to hydrogen atom location is shown to be useful in testing the reported hydrogen-bonded structure of Na(2)HPO(4).	Hydrogen	34-42	endothelin receptor type A	Homo sapiens	19-22
15681132-7	2005	The sensitivity of eta((23)Na) to hydrogen atom location is shown to be useful in testing the reported hydrogen-bonded structure of Na(2)HPO(4).	Hydrogen	103-111	endothelin receptor type A	Homo sapiens	19-22
8580850-1	1995	A genetically engineered protein consisting of the 120 residues at the N-terminus of human protein disulfide isomerase (PDI) has been characterized by 1H, 13C, and 15N NMR methods.	Hydrogen	151-153	prolyl 4-hydroxylase subunit beta	Homo sapiens	91-118
15829627-6	2005	We show here that mutations that disrupt one such cross-cleft hydrogen bond (in the AMPA receptor subunit GluR2) decrease both agonist affinity and efficacy.	Hydrogen	62-70	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	106-111
8580850-1	1995	A genetically engineered protein consisting of the 120 residues at the N-terminus of human protein disulfide isomerase (PDI) has been characterized by 1H, 13C, and 15N NMR methods.	Hydrogen	151-153	prolyl 4-hydroxylase subunit beta	Homo sapiens	120-123
7578072-11	1995	The effect of the N-terminal truncation on the cystatin A structure was examined by comparing the 1H-15N HSQC spectrum of cystatin A2-98 with that of the cystatin A5-98 variant, which lacks the anti-papain activity, revealing significant chemical shift differences in the residual N-terminal segment and the first binding loop, together with small shifts in the other parts.	Hydrogen	98-100	cystatin A	Homo sapiens	47-57
21582271-2	2009	Inter-molecular hydrogen bonds and C-H  pi inter-actions produce R(2) (2)(10), R(4) (4)(27) and R(4) (4)(29) rings.	Hydrogen	16-24	CD1a molecule	Homo sapiens	79-83
7562931-4	1995	These compounds inhibit HNE by forming both a covalent bond between the ketone carbonyl carbon atom and the hydroxyl group of Ser-195 and a hydrogen bond between the benzoxazole nitrogen atom and His-57.	Hydrogen	140-148	elastase, neutrophil expressed	Homo sapiens	24-27
21582271-2	2009	Inter-molecular hydrogen bonds and C-H  pi inter-actions produce R(2) (2)(10), R(4) (4)(27) and R(4) (4)(29) rings.	Hydrogen	16-24	CD1a molecule	Homo sapiens	96-100
19191477-8	2009	The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide.	Hydrogen	100-108	LOC100508689	Homo sapiens	237-242
15777558-3	2005	Serum apoC-I was 20% lower in the presence of the H2 allele in APOE epsilon3/epsilon3 homozygotes (P=0.003) but did not differ by H2 status in epsilon4 carriers.	Hydrogen	50-52	apolipoprotein C1	Homo sapiens	6-12
19402495-4	2009	Cyclic voltammetry results reveal that the large hydrogen adsorption peak current of -100 mA on Pd/PPy/foam-Ni electrode was obtained at about -500 mV (vs Hg/Hg2 SO4).	Hydrogen	49-57	pancreatic polypeptide	Homo sapiens	99-102
7547867-2	1995	2D 15N--1H HSQC NMR experiments of native PF4 in solution show the presence of conformational heterogeneity consistent with the formation of asymmetric homo-tetramers as observed in the X-ray crystal structure of both human and bovine PF4.	Hydrogen	8-10	platelet factor 4	Homo sapiens	42-45
7547867-4	1995	The solution structure of PF4-M2 has been investigated by using two- and three-dimensional 1H- and 15N-NMR spectroscopy and NOE-restrained simulated annealing molecular dynamics.	Hydrogen	91-93	platelet factor 4	Homo sapiens	26-32
19180617-0	2009	Addition of hydrogen or ammonia to a low-valent group 13 metal species at 25 degrees C and 1 atmosphere.	Hydrogen	12-20	cullin associated and neddylation dissociated 1	Homo sapiens	85-92
7657098-5	1995	RESULTS: Perfusion of the antral sleeve lumen with media of increasing hydrogen ion concentration caused pH-dependent increases in CGRP and somatostatin release and decrease in gastrin release.	Hydrogen	71-79	calcitonin-related polypeptide alpha	Rattus norvegicus	131-135
8527646-6	1995	For BUSI IIA (pH 4-5) and calbindin D9K (pH 6-7) the majority of amide protons with negative pH dependence of kex are located in chains of hydrogen-bonded peptides; this situation is shown to be consistent with the proposed mechanism.	Hydrogen	139-147	S100 calcium binding protein G	Bos taurus	26-39
15721299-2	2005	Our data show that the Plg/Pla-stimulated steady-state mRNA levels of both genes reached a maximum by 30 min and then returned to basal levels by 1h.	Hydrogen	146-148	plasminogen	Homo sapiens	23-26
15721299-2	2005	Our data show that the Plg/Pla-stimulated steady-state mRNA levels of both genes reached a maximum by 30 min and then returned to basal levels by 1h.	Hydrogen	146-148	plasminogen	Homo sapiens	27-30
19636903-0	2008	Assignment of the 1H, 13C and 15N resonances of the calponin homology-2 domain of alpha-actinin-4.	Hydrogen	18-20	actinin alpha 4	Homo sapiens	82-97
18498105-8	2008	In particular, the catalytic aspartates act as hydrogen bond acceptors for the N-terminal amino group and the Ser2 hydroxyl in plasmepsin, and the side chains of Lys36pro and Tyr9 in pepsinogen.	Hydrogen	47-55	jagged canonical Notch ligand 2	Homo sapiens	110-114
15924082-4	2005	RESULTS: The first 1H-MRS study of 2 concentric ring-enhanced lesions showed a decreased N-acetyl-aspartate (NAA) peak, an increased choline peak, 2 broad lactate peaks and the presence of a lipid peak at 0.9 ppm.	Hydrogen	19-21	PEAK1 related, kinase-activating pseudokinase 1	Homo sapiens	141-148
15837191-5	2005	These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70.	Hydrogen	157-165	ubiquitin	Saccharomyces cerevisiae S288C	57-66
15837191-5	2005	These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70.	Hydrogen	157-165	ubiquitin	Saccharomyces cerevisiae S288C	133-142
7551045-6	1995	We describe this effect in detail, attributable to the hupT gene, which has been proposed to encode a histidine-kinase for the hydrogen uptake system in Rhodobacter capsulatus.	Hydrogen	127-135	PAS domain-containing protein	Rhodobacter sphaeroides 2.4.1	55-59
7551045-7	1995	The effect of HupT on the expression of the photosynthesis genes was mediated through PrrA and independent of a functioning hydrogen uptake system.	Hydrogen	124-132	PAS domain-containing protein	Rhodobacter sphaeroides 2.4.1	14-18
15837191-5	2005	These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70.	Hydrogen	157-165	ubiquitin	Saccharomyces cerevisiae S288C	133-142
7612603-1	1995	The reversible cold, heat, and pressure unfolding of RNase A and RNase A--inhibitor complex were studied by 1D and 2D 1H NMR spectroscopy.	Hydrogen	118-120	ribonuclease A family member 1, pancreatic	Homo sapiens	53-60
18834901-7	2008	LC-MS/MS analysis of brain prostaglandin profile in COX-2(-/-) mice demonstrated a significant increase in PGF(2alpha), TXB(2), PGE(2) and PGD(2) expression 1h after administration of an excitotoxic dose of KA, but not of NMDA.	Hydrogen	157-159	cytochrome c oxidase II, mitochondrial	Mus musculus	52-57
7612603-1	1995	The reversible cold, heat, and pressure unfolding of RNase A and RNase A--inhibitor complex were studied by 1D and 2D 1H NMR spectroscopy.	Hydrogen	118-120	ribonuclease A family member 1, pancreatic	Homo sapiens	65-72
7663142-1	1995	We present the complete 15N and 1H NMR assignment and the secondary structure of an immunoglobulin-like domain from the giant muscle protein titin.	Hydrogen	32-34	titin	Homo sapiens	141-146
15698804-4	2005	A plausible model was proposed, in which all polar atoms of (d)-1 are linked by hydrogen bonds or electrostatic interactions with the functional residues of ICAM-1, that have been supposed to be necessary for the binding with LFA-1 (leukocyte function-associated antigen-1).	Hydrogen	80-88	integrin subunit alpha L	Homo sapiens	226-231
15709964-1	2005	The sodium/hydrogen exchange (NHE) gene family plays an integral role in neutral sodium absorption in the mammalian intestine.	Hydrogen	11-19	solute carrier family 9 member C1	Homo sapiens	30-33
7483668-9	1995	This provides strong evidence that P450 oxidatively dealkylates the amines by a hydrogen atom transfer mechanism and not by an electron/proton transfer mechanism.	Hydrogen	80-88	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	35-39
18765262-7	2008	Intracerebroventricular administration of QRFP-26 (3.0nM, 5.0nM) and QRFP-43 (1.0nM, 3.0nM) dose-dependently increased 1h, 2h, and 4h cumulative intake of high fat (55% fat), but not low fat (10% fat) diet.	Hydrogen	119-121	pyroglutamylated RFamide peptide	Rattus norvegicus	42-46
7731041-8	1995	*A12+ modification site pair forms a weak central Watson-Crick hydrogen bond in contrast to all A.T and G.C pairs, which align through standard Watson-Crick pairing in the complex.	Hydrogen	63-71	immunoglobulin kappa variable 2D-19 (pseudogene)	Homo sapiens	1-4
7893675-1	1995	The three-dimensional structure in aqueous solution of the 49-residue polypeptide anthopleurin-A (AP-A), from the sea anemone Anthopleura xanthogrammica, has been determined from 1H NMR data.	Hydrogen	179-181	glutamyl aminopeptidase	Homo sapiens	98-102
15616703-6	2005	This was ascribed to the formation of hydrogen bonds between 8PCzC molecules in both SmA and isotropic phases.	Hydrogen	38-46	survival of motor neuron 1, telomeric	Homo sapiens	85-88
18765262-7	2008	Intracerebroventricular administration of QRFP-26 (3.0nM, 5.0nM) and QRFP-43 (1.0nM, 3.0nM) dose-dependently increased 1h, 2h, and 4h cumulative intake of high fat (55% fat), but not low fat (10% fat) diet.	Hydrogen	119-121	pyroglutamylated RFamide peptide	Rattus norvegicus	69-73
18811183-3	2008	The redox potential (relative to the standard hydrogen potential) of the Pu(VII)/Pu(VIII) couple in alkaline solution was found to vary from 4.36 to 1.06 V depending on the number of Pu-O oxo bonds, coordination numbers, and coordination modes.	Hydrogen	46-54	cytochrome c oxidase subunit 8A	Homo sapiens	84-88
15505811-4	2004	It is also found that the binding preference of CDK4- selective inhibitors for CDK4 over CDK2 stems from the reduced solvent accessibility in the active site of the former due to the formation of a stable hydrogen-bond triad by the Asp99, Arg101, and Thr102 side chains at the top of the active-site gorge.	Hydrogen	205-213	cyclin dependent kinase 4	Homo sapiens	48-52
15505811-4	2004	It is also found that the binding preference of CDK4- selective inhibitors for CDK4 over CDK2 stems from the reduced solvent accessibility in the active site of the former due to the formation of a stable hydrogen-bond triad by the Asp99, Arg101, and Thr102 side chains at the top of the active-site gorge.	Hydrogen	205-213	cyclin dependent kinase 4	Homo sapiens	79-83
15505811-4	2004	It is also found that the binding preference of CDK4- selective inhibitors for CDK4 over CDK2 stems from the reduced solvent accessibility in the active site of the former due to the formation of a stable hydrogen-bond triad by the Asp99, Arg101, and Thr102 side chains at the top of the active-site gorge.	Hydrogen	205-213	cyclin dependent kinase 2	Homo sapiens	89-93
15505811-5	2004	Besides the differences in loop flexibility and solvent accessibility, the dynamic stabilities of the hydrogen bonds between the inhibitors and the side chain of the lysine residue at the bottom of the active site also correlate well with the relative binding affinities of the inhibitors for the two CDKs.	Hydrogen	102-110	cyclin dependent kinase 2	Homo sapiens	301-305
7880831-3	1995	These low-barrier hydrogen bonds are associated respectively with a side chain proton, the PLP pyridinium ring nitrogen proton, and the PLP Schiff base proton at the active site of the ligase.	Hydrogen	18-26	pyridoxal phosphatase	Homo sapiens	91-94
7880831-3	1995	These low-barrier hydrogen bonds are associated respectively with a side chain proton, the PLP pyridinium ring nitrogen proton, and the PLP Schiff base proton at the active site of the ligase.	Hydrogen	18-26	pyridoxal phosphatase	Homo sapiens	136-139
7873586-7	1995	Proton nuclear magnetic resonance (1H-NMR) study revealed that rMIF was less thermostable (the denaturing temperature was from 50-60 degrees C) than human MIF (the denaturing temperature is about 80 degrees C (Nishihira et al.	Hydrogen	35-37	macrophage migration inhibitory factor	Homo sapiens	64-67
7837273-5	1995	In Ala68 deoxymyoglobin, as in the wild-type protein, a water molecule hydrogen-bonded to the N epsilon atom of the distal histidine restricts ligand binding and appears to be more important in regulating the function of myoglobin than direct steric interactions between the ligand and the C gamma atoms of the native valine side-chain.	Hydrogen	71-79	myoglobin	Physeter catodon	14-23
18621810-1	2008	The [FeFe] hydrogenase from the green alga Chlamydomonas reinhardtii can catalyze the reduction of protons to hydrogen gas using electrons supplied from photosystem I and transferred via ferredoxin.	Hydrogen	11-19	uncharacterized protein	Chlamydomonas reinhardtii	187-197
7851394-5	1995	The glutaredoxin preparation showed GSH-dependent hydrogen-donor activity with recombinant mouse ribonucleotide reductase, it exhibited dehydroascorbate reductase activity as well as hydroxyethyl-disulfide-reducing activity.	Hydrogen	50-58	glutaredoxin	Homo sapiens	4-16
15537345-5	2004	Placement of a hydrogen-bond donor in the meta-position on the 6-arylmethyl group resulted in approximately 100-fold increases in CDK4 affinity, giving ligands that were equipotent inhibitors of CDK4 and CDK2.	Hydrogen	15-23	cyclin dependent kinase 4	Homo sapiens	130-134
15537345-5	2004	Placement of a hydrogen-bond donor in the meta-position on the 6-arylmethyl group resulted in approximately 100-fold increases in CDK4 affinity, giving ligands that were equipotent inhibitors of CDK4 and CDK2.	Hydrogen	15-23	cyclin dependent kinase 4	Homo sapiens	195-199
15537345-5	2004	Placement of a hydrogen-bond donor in the meta-position on the 6-arylmethyl group resulted in approximately 100-fold increases in CDK4 affinity, giving ligands that were equipotent inhibitors of CDK4 and CDK2.	Hydrogen	15-23	cyclin dependent kinase 2	Homo sapiens	204-208
18708277-7	2008	Difference between the calculated QCC and eta(Q) values revealed how hydrogen-bonding interactions affect EFG tensors at the sites of each oxygen nucleus.	Hydrogen	69-77	endothelin receptor type A	Homo sapiens	42-45
15500365-7	2004	Compound 8 reacts with hydrogen to give the dihydrido complex Ru(5)(CO)(11)(eta(6)-C(6)H(6))(mu(6)-C)[Pt(PBu(t)(3))](mu-H)(2), 10, in 59% yield.	Hydrogen	23-31	endothelin receptor type A	Homo sapiens	76-79
7819190-2	1995	Sharp resonances in the 1H NMR spectrum of the Pf1 nucleoprotein complex indicate that the C-terminal region of the protein subunits enjoys remarkable conformational flexibility in the complex.	Hydrogen	24-26	PHD finger protein 12	Homo sapiens	47-50
21201178-3	2008	The mol-ecules are linked by N-H O hydrogen bonds, forming cyclic structures with R(4) (4)(24) graph-set motifs.	Hydrogen	35-43	CD1a molecule	Homo sapiens	82-86
18654997-8	2008	Literature data reported a conserved pattern of hydrogen bonds between a single water molecule and three amino acid residues of the binding site in a series of crystallized FABP.	Hydrogen	48-56	fatty acid binding protein 2	Gallus gallus	173-177
7572450-7	1995	The hCG group exhibited no signs of heat, and the follicles only reached 5-8 mm in diameter at time of ovulation, which occurred 40h +/- 1h after hCG-injection.	Hydrogen	137-139	hypertrichosis 2 (generalised, congenital)	Homo sapiens	146-149
7895308-4	1995	In the 7-piperazinyl series, addition of a fluorine at C-8, which increased the in vitro activity for the 1-hydrogen and 1-methyl analogues and decreased it for the 1-phenyl analogue, improved the in vivo activity of all the analogues.	Hydrogen	108-116	homeobox C8	Homo sapiens	55-58
15585942-2	2004	The assay is a homologous double-antibody EIA with E2beta 17hemisuccinate (HS) as hapten for the immunoreactive reagent.	Hydrogen	75-77	dihydrolipoamide branched chain transacylase E2	Bos taurus	51-57
15494440-4	2004	Mapping of the rarely found (in E. coli and yeast genomes) hydrophobicity patterns in helix 2 (H2) to known secondary structures suggests that the PrPC--&gt;PrPC* transition must be accompanied by alterations in conformations in second half of H2.	Hydrogen	244-246	prion protein	Mus musculus	147-151
18540644-7	2008	The presence of 8 mol/L urea or 10% v/v ethanol in solutions also affects mucin aggregation in the presence of chitosan, demonstrating the role of hydrogen bonding and hydrophobic effects, respectively, in mucoadhesion.	Hydrogen	147-155	LOC100508689	Homo sapiens	74-79
7813465-6	1994	A comparison of the DNA sequences protected by AP-2 against DNase I digestion revealed a consensus AP-2-binding site of 5"-GSCCCDSS-3", where S represents a base pairing involving three (C or G) hydrogen bonds and D represents any base other than C. The nucleotide sequences of the bovine beta-subunit structural genes also are reported.	Hydrogen	195-203	deoxyribonuclease 1	Bos taurus	60-67
18449534-1	2008	The stability and secondary structure propensity of recombinant murine 18.5 kDa myelin basic protein (rmMBP, 176 residues) was assessed using circular dichroic and nuclear magnetic resonance spectroscopy (1H-15N HSQC experiments) to determine the optimal sample conditions for further NMR studies (i.e., resonance assignments and protein-protein interactions).	Hydrogen	205-207	myelin basic protein	Mus musculus	80-100
7990129-11	1994	The binding loop of CsA (residues 1 to 3 and 9 to 11) comprising 42% of the CsA surface, is buried in the peptidyl-prolyl-cis-trans isomerase active site of the cognate binding partner CypA, while the effector loop (residues 4 to 8) packs in the core of the decamer making hydrogen-bonding and van der Waals contacts with three neighbouring molecules.	Hydrogen	273-281	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	20-23
7990129-11	1994	The binding loop of CsA (residues 1 to 3 and 9 to 11) comprising 42% of the CsA surface, is buried in the peptidyl-prolyl-cis-trans isomerase active site of the cognate binding partner CypA, while the effector loop (residues 4 to 8) packs in the core of the decamer making hydrogen-bonding and van der Waals contacts with three neighbouring molecules.	Hydrogen	273-281	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	76-79
7699133-4	1994	Breath hydrogen was reduced 39% following ingestion of high lactase yogurt from that after consumption of conventional yogurt, indicating that the high lactase yogurt enhanced lactose absorption.	Hydrogen	7-15	lactase	Homo sapiens	60-67
7699133-4	1994	Breath hydrogen was reduced 39% following ingestion of high lactase yogurt from that after consumption of conventional yogurt, indicating that the high lactase yogurt enhanced lactose absorption.	Hydrogen	7-15	lactase	Homo sapiens	152-159
15372652-8	2004	A first-order rate dependence on the hydrogen pressure was determined for the BArF- and the PF6- salts.	Hydrogen	37-45	sperm associated antigen 17	Homo sapiens	92-95
15557805-0	2004	1H, 13C and 15N resonance assignments of poplar phloem glutaredoxin.	Hydrogen	0-2	glutaredoxin	Homo sapiens	55-67
15557809-0	2004	1H, 15N and 13C resonance assignments of complement control protein module pair 2-3 from the C4b-binding site of complement receptor type 1.	Hydrogen	0-2	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	113-139
18844153-2	2008	The temperature-dependent FTIR studies revealed that the hydrogen bonding in complex PCBA-BPy was very different from that in PCCA-BPy.	Hydrogen	57-65	propionyl-CoA carboxylase subunit alpha	Homo sapiens	126-130
15379576-5	2004	Primase only polymerized NTP analogues containing bases capable of forming hydrogen bonds between the equivalent of both N-1 and the exocyclic group at C-6 of a purine NTP (2-fluoroadenine, 2-chloroadenine, 3-deazaadenine, and hypoxanthine) and N-3 and the exocyclic group at C-4 of a pyrimidine.	Hydrogen	75-83	complement C6	Homo sapiens	152-155
15325268-3	2004	The early increase in the Tg synthesis within 1h after stimulation apparently triggers UPR as it is evidenced by the activation of ATF6- and PERK-dependent pathways of UPR and subsequent expression of the UPR target genes, ER molecular chaperones.	Hydrogen	46-48	thyroglobulin	Homo sapiens	26-28
7696215-1	1994	The historical model for the agonistic binding site on the histamine H2-receptor is based on a postulated activation mechanism: it has been suggested that the histamine monocation binds to the histamine H2-receptor via the formation of three hydrogen bonds.	Hydrogen	242-250	histamine receptor H2	Homo sapiens	193-214
7947760-2	1994	The secondary structure of the ETS domain of murine Ets-1 was determined on the basis of NMR chemical shifts, NOE and J-coupling constraints, amide hydrogen exchange, circular dichroism, and FT-IR spectroscopy.	Hydrogen	148-156	E26 avian leukemia oncogene 1, 5' domain	Mus musculus	52-57
15315443-1	2004	A striking feature of sulfate (SO(4)(2-)) and molybdate (MoO(4)(2-)) transport proteins, such as SBP and ModA, which specifically bind SO(4)(2-) and MoO(4)(2-), respectively, is their ability to discriminate very similar anions with the same net charge, geometry, and hydrogen-bonding properties.	Hydrogen	268-276	selenium binding protein 1	Homo sapiens	97-100
18482735-11	2008	Residues 154 and 240 in TPMT*3A are connected through a hydrogen-bonding network.	Hydrogen	56-64	thiopurine S-methyltransferase	Homo sapiens	24-28
15305215-2	2004	NMR analysis clearly indicated that the 2Dpy-containing tripeptides except the peptide in which AA1, AA3 = Aib, adopt a unique conformation with two intramolecular hydrogen bonds between 2Dpy-NH and a pyridine nitrogen and between AA3-NH and another pyridine nitrogen.	Hydrogen	164-172	AA1	Homo sapiens	96-99
15273299-9	2004	For PQQH--&gt;PQQH2, migration of H5 to the C4 oxygen may be assisted by a weak base like water (either by crystal water Wat97 or bulk solvent, hydrogen-bonded to Glu 171-CO2- in MDH and by Wat89 in sGDH).	Hydrogen	144-152	NADH:ubiquinone oxidoreductase subunit B5	Homo sapiens	199-203
7866747-8	1994	The protein-CsA interactions in both the Fab and CypA complexes involve five hydrogen bonds, and the buried CsA surface areas are 395 A2 and 300 A2, respectively.	Hydrogen	77-85	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	12-15
18459727-4	2008	Complex 1 forms a hydrogen-bonded one-dimensional metal-organic framework that stabilizes a helical water chain into its cavity, but when any of the amine hydrogen atoms of the Schiff base are replaced by methyl groups, as in L2 and L3, the water chain vanishes, showing explicitly the importance of the host-guest H-bonding interactions for the stabilization of a water cluster.	Hydrogen	18-26	immunoglobulin kappa variable 3-15	Homo sapiens	226-235
7937896-0	1994	Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant.	Hydrogen	76-84	glutaredoxin	Homo sapiens	15-27
7937896-0	1994	Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant.	Hydrogen	76-84	glutaredoxin	Homo sapiens	137-151
7937896-1	1994	Thioredoxin (Trx) and glutaredoxin (Grx1) are hydrogen donors for ribonucleotide reductase, the key enzyme for deoxyribonucleotide biosynthesis.	Hydrogen	46-54	glutaredoxin	Homo sapiens	22-34
7937896-1	1994	Thioredoxin (Trx) and glutaredoxin (Grx1) are hydrogen donors for ribonucleotide reductase, the key enzyme for deoxyribonucleotide biosynthesis.	Hydrogen	46-54	glutaredoxin	Homo sapiens	36-40
7937896-2	1994	The viability of a double mutant lacking both Trx and Grx1 implies the presence of a third, unknown hydrogen donor.	Hydrogen	100-108	glutaredoxin	Homo sapiens	54-58
7937896-10	1994	The combination of the Grx3 hydrogen donor activity and a 25-fold induction of ribonucleotide reductase activity in a delta trxA, grx double mutant provides an explanation for its viability and deoxyribonucleotide biosynthesis.	Hydrogen	28-36	glutaredoxin	Homo sapiens	130-133
7727360-1	1994	The globular domain of chicken histone H1 (GH1) has been studied by 1H homonuclear and 1H-15N heteronuclear 2D NMR spectroscopy.	Hydrogen	68-70	growth hormone	Gallus gallus	43-46
15257619-1	2004	Recently, we established that 13S-hydroperoxy-linoleic acid is converted to 4S-hydroperoxy-nonenal (4S-HPNE) during autoxidation, implicating hydrogen abstraction from C-8 as an initiating step [Schneider, C., et al.	Hydrogen	142-150	homeobox C8	Homo sapiens	168-171
15213453-0	2004	Backbone and sidechain 1H, 13C and 15N resonance assignments of human cofilin.	Hydrogen	23-25	cofilin 1	Homo sapiens	70-77
15213455-0	2004	1H, 13C and 15N backbone resonance assignments for TEM-1, a 28.9 kDa beta-lactamase from E. coli.	Hydrogen	0-2	hypothetical protein	Escherichia coli	51-56
15213455-0	2004	1H, 13C and 15N backbone resonance assignments for TEM-1, a 28.9 kDa beta-lactamase from E. coli.	Hydrogen	0-2	beta-lactamase	Escherichia coli	69-83
7727360-1	1994	The globular domain of chicken histone H1 (GH1) has been studied by 1H homonuclear and 1H-15N heteronuclear 2D NMR spectroscopy.	Hydrogen	87-89	growth hormone	Gallus gallus	43-46
21202637-2	2008	Intra-molecular C-H N and C-H O hydrogen bonds result in the formation of one five- and two six-membered non-planar rings.	Hydrogen	32-40	chimerin 1	Homo sapiens	16-29
15010500-1	2004	Previously, we demonstrated that malignant glioma cell lines have increased intracellular pH (pHi) as a result of increased activities of the type I sodium/hydrogen exchanger (NHE1).	Hydrogen	156-164	glucose-6-phosphate isomerase	Homo sapiens	94-97
18319316-0	2008	1H magnetic resonance spectroscopy in monocarboxylate transporter 8 gene deficiency.	Hydrogen	0-2	solute carrier family 16 member 2	Homo sapiens	38-67
15163180-3	2004	An X-ray crystal structure of 26 in MMP-13 confirms the key hydrogen bonds and prime side binding in the active site.	Hydrogen	60-68	matrix metallopeptidase 13	Mus musculus	36-42
11539176-3	1994	Good agreement between models and observations of CO, O2, O3, and the escape flux of atomic hydrogen can be achieved, using only gas-phase chemistry, by varying the recommended rate constants for the reactions CO + OH and OH + HO2 within their specified uncertainties.	Hydrogen	92-100	heme oxygenase 2	Homo sapiens	227-230
18429027-0	2008	Fat suppression for 1H MRSI at 7T using spectrally selective adiabatic inversion recovery.	Hydrogen	20-22	FAT atypical cadherin 1	Homo sapiens	0-3
7800118-3	1994	Two of these clones were characterized further and one clone, pC26.H2, was found to be closely related to mouse stearoyl-CoA desaturase 2 (SCD2), which catalyzes the synthesis of unsaturated fatty acid.	Hydrogen	67-69	stearoyl-Coenzyme A desaturase 2	Mus musculus	112-137
7800118-3	1994	Two of these clones were characterized further and one clone, pC26.H2, was found to be closely related to mouse stearoyl-CoA desaturase 2 (SCD2), which catalyzes the synthesis of unsaturated fatty acid.	Hydrogen	67-69	stearoyl-Coenzyme A desaturase 2	Mus musculus	139-143
8206982-0	1994	Null thioredoxin and glutaredoxin Escherichia coli K-12 mutants have no enhanced sensitivity to mutagens due to a new GSH-dependent hydrogen donor and high increases in ribonucleotide reductase activity.	Hydrogen	132-140	glutaredoxin	Homo sapiens	21-33
8206982-1	1994	This work investigates whether a mutator phenotype is associated to the simultaneous deficiency in thioredoxin and glutaredoxin, the two known hydrogen donors of ribonucleotide reductase.	Hydrogen	143-151	glutaredoxin	Homo sapiens	115-127
15178310-4	2004	Because of the dominantly electrostatic nature of this bond, molecular-electrostatic potential was considered and the highest electrostatic potential on the solvent accessible surface (ESP+) was used as the hydrogen-bonding-donor ability of the molecule.	Hydrogen	207-215	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	185-188
15178310-7	2004	The results suggested that ESP+ was superior to the atomic charge descriptor and that the use of this parameter as the hydrogen bonding parameter in QSAR studies was successful.	Hydrogen	119-127	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	27-30
15154811-9	2004	The presence of the C ansa bridge is shown to decrease the ability of the metallocene fragment to donate to the hydrogens, thus stabilizing the (eta(2)-H(2)) unit and modulating the barrier to H(2) rotation.	Hydrogen	112-121	endothelin receptor type A	Homo sapiens	75-78
8206982-6	1994	The existence of a new glutathione-dependent hydrogen donor for ribonucleotide reductase and the high activity levels of this enzyme in trx-grx- defective cells could explain that thioredoxin and the first discovered glutaredoxin are not essential for deoxyribonucleotide synthesis, even under mutagenic stress.	Hydrogen	45-53	glutaredoxin	Homo sapiens	140-143
8206982-6	1994	The existence of a new glutathione-dependent hydrogen donor for ribonucleotide reductase and the high activity levels of this enzyme in trx-grx- defective cells could explain that thioredoxin and the first discovered glutaredoxin are not essential for deoxyribonucleotide synthesis, even under mutagenic stress.	Hydrogen	45-53	glutaredoxin	Homo sapiens	217-229
15155853-6	2004	The pBQ-C/APE1 complex, generated by MD, has a similar hydrogen bond network between target phosphodiester bond at the pBQ-C site and key amino acids at the active site, as in the crystallographically determined APE1 complexed with an AP site-containing DNA duplex.	Hydrogen	55-63	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	10-14
18373354-2	2008	Glu162 in homotetrameric human MnSOD spans a dimeric interface and forms a hydrogen bond with His163 of an adjacent subunit which is a direct ligand of the manganese.	Hydrogen	75-83	superoxide dismutase 2	Homo sapiens	31-36
15056609-3	2004	Our phenotypic and biochemical analyses reveal that HS levels are dramatically reduced in the absence of Sotv or its partner co-polymerase Tout velu (Ttv), suggesting that both copolymerases are essential for GAG synthesis.	Hydrogen	52-54	sister of tout-velu	Drosophila melanogaster	105-109
14766795-6	2004	Molecular modeling studies showed that the capability of CA inhibitors to open the BK channel was related to the presence in their structures of an intra-molecular hydrogen bond with calculated inter-atomic distances ranging between 1.82 A degrees and 3.01 A degrees and of an aromatic ring poor of electrons.	Hydrogen	164-172	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	83-93
8011951-2	1994	This database is made of all the pairing schemes of the triplets ATT, GCC+, ATA and GCG where the third base forms two hydrogen bonds with the purine of the first two Watson-Crick strands.	Hydrogen	119-127	guanylate cyclase 2C	Homo sapiens	70-73
7973820-4	1994	Repeated measurements of 3% H2 clearance for 1.5 min further showed that clearance test using low H2 concentration for short term periods reflected better the rCBF of experimental animals.	Hydrogen	98-100	CCAAT/enhancer binding protein zeta	Rattus norvegicus	159-163
18373354-4	2008	The X-ray crystal structures of E162D and E162A MnSOD reveal no significant structural changes compared with the wild type other than the removal of the hydrogen bond interaction with His163 in E162A MnSOD.	Hydrogen	153-161	superoxide dismutase 2	Homo sapiens	200-205
14718582-10	2004	In conclusion, DHPs indirectly alter NTR1 function in live cells by a mechanism that depends on the drug"s ability to donate hydrogen but does not simply involve sulfhydryl reduction.	Hydrogen	125-133	neurotensin receptor 1	Homo sapiens	37-41
8155661-4	1994	The adduct with the unsubstituted hydrazine was instead assigned an o-quinone hydrazone form, stabilized by an internal hydrogen bond between the amino group and the ortho carbonyl oxygen, a larger electron delocalization, and formation of a hydrogen bond at the C-6 ionized hydroxyl.	Hydrogen	120-128	complement C6	Homo sapiens	263-266
8155661-4	1994	The adduct with the unsubstituted hydrazine was instead assigned an o-quinone hydrazone form, stabilized by an internal hydrogen bond between the amino group and the ortho carbonyl oxygen, a larger electron delocalization, and formation of a hydrogen bond at the C-6 ionized hydroxyl.	Hydrogen	242-250	complement C6	Homo sapiens	263-266
18373354-5	2008	In the case of E162D MnSOD, an intervening solvent molecule fills the void created by the mutation to conserve the hydrogen bond interaction between His163 and residue 162.	Hydrogen	115-123	superoxide dismutase 2	Homo sapiens	21-26
18373354-8	2008	Differential scanning calorimetry indicates that the hydrogen bond between Glu162 and His163 contributes to the stability of MnSOD, with the major unfolding transition occurring at 81 degrees C for E162A compared to 90 degrees C for wild-type MnSOD.	Hydrogen	53-61	superoxide dismutase 2	Homo sapiens	125-130
8125933-11	1994	They indicate, furthermore, that hydrogen abstraction and oxygen addition occur in an antarafacial manner and suggest a specific model for binding of linoleic acid within the myoglobin active site.	Hydrogen	33-41	myoglobin	Physeter catodon	175-184
18373354-8	2008	Differential scanning calorimetry indicates that the hydrogen bond between Glu162 and His163 contributes to the stability of MnSOD, with the major unfolding transition occurring at 81 degrees C for E162A compared to 90 degrees C for wild-type MnSOD.	Hydrogen	53-61	superoxide dismutase 2	Homo sapiens	243-248
18053681-8	2008	Instead, ErbB3 receptor was overexpressed after 1h, returned to basal level after 4h and increased its level after 24h.	Hydrogen	48-50	erb-b2 receptor tyrosine kinase 3	Homo sapiens	9-14
8286326-5	1994	Exchange broadening of the 15N-1H correlations upon titration of 15N labeled HSF with a 13-base-pair DNA duplex suggests a DNA-binding motif in which the third helix acts as the recognition helix.	Hydrogen	31-33	Heat shock factor	Drosophila melanogaster	77-80
18199454-9	2008	The reduction in diffusion coefficient is likely to due to structural changes in the AS-1 and AS-2 helices such that hydrogen bonding with the surrounding water molecules is increased, thereby increasing friction with the solvent.	Hydrogen	117-125	prostaglandin D2 receptor	Homo sapiens	85-89
8289201-0	1994	FTIR spectral study of intramolecular hydrogen bonding in thromboxane A2 receptor agonist (U-46619), prostaglandin (PG)E2, PGD2, PGF2 alpha, prostacyclin receptor agonist (carbacyclin), and their related compounds in dilute CCl4 solution: structure-activity relationships.	Hydrogen	38-46	prostaglandin I2 receptor	Homo sapiens	141-162
8289201-1	1994	FTIR spectra measurements and full optimization curve analysis of their spectra were done to obtain parameters of the OH and C = O stretching vibration bands for intramolecular hydrogen bondings in thromboxane (TX)A2 receptor partial agonist (CTA2), prostaglandin (PG)E2, PGD2, PGF2 alpha, prostacyclin (PGI2) receptor agonist (carbacyclin), and their related compounds in dilute CCl4 solutions.	Hydrogen	177-185	prostaglandin I2 receptor	Homo sapiens	290-318
8312479-0	1993	Investigation of secondary and tertiary structural changes of cytochrome c in complexes with anionic lipids using amide hydrogen exchange measurements: an FTIR study.	Hydrogen	120-128	LOC104968582	Bos taurus	62-74
15035638-6	2004	Moreover, electrostatic and hydrogen-bonding interactions occur between the terminal lysine residues of L(24) and L(24)DAP and the polar headgroups of PG bilayers.	Hydrogen	28-36	death associated protein	Homo sapiens	119-122
15268303-0	2004	Energy transfer in Li(4p) + (Ar,H2,CH4) collisions.	Hydrogen	32-34	lipase family member N	Homo sapiens	19-24
15134488-7	2004	We focused on the amide function of these compounds because recent investigations revealed that both the amide hydrogen and carbonyl oxygen of indolactam-V (ILV) are involved in hydrogen bonding with the C1B domains of PKCdelta.	Hydrogen	111-119	protein kinase C delta	Homo sapiens	219-227
15134488-7	2004	We focused on the amide function of these compounds because recent investigations revealed that both the amide hydrogen and carbonyl oxygen of indolactam-V (ILV) are involved in hydrogen bonding with the C1B domains of PKCdelta.	Hydrogen	178-186	protein kinase C delta	Homo sapiens	219-227
21693903-9	2008	The benzene-Ti-H(2) bonding is discussed on the basis of molecular orbital interaction schemes as provided by ADF.	Hydrogen	15-19	destrin, actin depolymerizing factor	Homo sapiens	110-113
15508429-5	2004	For example, in most cases it would appear that there is a set number of intervening "heavy" atoms (atoms other than hydrogen) between sites of metabolism and key hydrogen bond acceptors (or donors) for human P450 substrates, with the number of intervening atoms being dependent upon the type of P450 involved.	Hydrogen	117-125	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	209-213
15508429-5	2004	For example, in most cases it would appear that there is a set number of intervening "heavy" atoms (atoms other than hydrogen) between sites of metabolism and key hydrogen bond acceptors (or donors) for human P450 substrates, with the number of intervening atoms being dependent upon the type of P450 involved.	Hydrogen	117-125	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	296-300
15508429-5	2004	For example, in most cases it would appear that there is a set number of intervening "heavy" atoms (atoms other than hydrogen) between sites of metabolism and key hydrogen bond acceptors (or donors) for human P450 substrates, with the number of intervening atoms being dependent upon the type of P450 involved.	Hydrogen	163-171	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	209-213
8221676-8	1993	Results of one- and two-dimensional 1H NMR correlation spectroscopy on these peptides confirm that the muc-1 protein core is not a random-coil secondary structure.	Hydrogen	36-38	mucin 1, cell surface associated	Homo sapiens	103-108
8285630-0	1993	Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase.	Hydrogen	9-17	TEM-1 beta-lactamase	Escherichia coli	73-93
15508429-5	2004	For example, in most cases it would appear that there is a set number of intervening "heavy" atoms (atoms other than hydrogen) between sites of metabolism and key hydrogen bond acceptors (or donors) for human P450 substrates, with the number of intervening atoms being dependent upon the type of P450 involved.	Hydrogen	163-171	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	296-300
18281945-16	2008	The O (eta) atom of Tyr208 provides a hydrogen bond to stabilize the closed form of loop 6 by interacting with the amide nitrogen of Ala176; these atoms are outside of hydrogen bonding distance in the open form of the enzyme.	Hydrogen	38-46	endothelin receptor type A	Homo sapiens	7-10
15724919-6	2004	TT raised concentration of BTG in all the groups, induced a stable trend of F 1+2 rise in patients of subgroup 1H (p = 0.059), raised WF only in group 3, TPA antigen at peak stress in all the patients being in group 1 higher than in healthy controls and in subgroup 1A than in subgroup 1H.	Hydrogen	111-113	pro-platelet basic protein	Homo sapiens	27-30
8366081-7	1993	Because DPDase catalyzed the exchange of deuterium in [4S-2H,4R-1H]NADP2H with solvent protons with a rate constant of 5.4 s-1, which was significantly larger than that for tritium, the analogous rate constant for exchange of the 4-hydrogen in NADPH must be significantly larger than 5 s-1.	Hydrogen	232-240	dihydropyrimidine dehydrogenase	Bos taurus	8-14
8379930-3	1993	We show that a hydrogen bond to the C-3 position is involved in sugar binding for all three isoforms, but that the direction of this hydrogen bond is different in GLUT 2 from either GLUT 1, 3 or 4.	Hydrogen	15-23	complement C3 L homeolog	Xenopus laevis	36-39
8379930-3	1993	We show that a hydrogen bond to the C-3 position is involved in sugar binding for all three isoforms, but that the direction of this hydrogen bond is different in GLUT 2 from either GLUT 1, 3 or 4.	Hydrogen	133-141	complement C3 L homeolog	Xenopus laevis	36-39
8379930-4	1993	Hydrogen-bonding at the C-4 position is also involved in sugar recognition by all three isoforms, but we propose that in GLUT 3 this hydrogen bond plays a less significant role than in GLUT 2 and 4.	Hydrogen	0-8	solute carrier family 2 member 3 L homeolog	Xenopus laevis	121-127
8379930-4	1993	Hydrogen-bonding at the C-4 position is also involved in sugar recognition by all three isoforms, but we propose that in GLUT 3 this hydrogen bond plays a less significant role than in GLUT 2 and 4.	Hydrogen	133-141	solute carrier family 2 member 3 L homeolog	Xenopus laevis	121-127
18281945-16	2008	The O (eta) atom of Tyr208 provides a hydrogen bond to stabilize the closed form of loop 6 by interacting with the amide nitrogen of Ala176; these atoms are outside of hydrogen bonding distance in the open form of the enzyme.	Hydrogen	168-176	endothelin receptor type A	Homo sapiens	7-10
17890386-0	2008	Protonation and hydrogen bonding of Ca2+ site residues in the E2P phosphoenzyme intermediate of sarcoplasmic reticulum Ca2+-ATPase studied by a combination of infrared spectroscopy and electrostatic calculations.	Hydrogen	16-24	dynein axonemal heavy chain 8	Homo sapiens	124-130
14522984-4	2003	According to hydrogen exchange and stopped-flow intrinsic fluorescence data, unfolding of mAAT appears to be complete in less than 10 s, but hydrolysis of the Schiff base linking the coenzyme pyridoxal 5"-phosphate (PLP) to the polypeptide is much slower (k approximately 0.08 min(-1)).	Hydrogen	13-21	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	90-94
18661333-3	2008	This ubiquitously expressed sodium/hydrogen exchanger (NHE-1) plays a central housekeeping role in all cells regulating cell volume and internal pH (pHi).	Hydrogen	35-43	glucose-6-phosphate isomerase	Homo sapiens	149-152
14636050-3	2003	In the structure of l-amino acid oxidase complexed with aminobenzoate, Tyr372 hydrogen bonds with the carboxylate of the inhibitor in the active site.	Hydrogen	78-86	interleukin 4 induced 1	Homo sapiens	20-40
14634667-2	2003	Two sodium-hydrogen exchangers (NHE1 and NHE5) are expressed in spermatozoa.	Hydrogen	11-19	solute carrier family 9 member A5	Homo sapiens	41-45
18661333-4	2008	At physiological pHi, NHE-1 is essentially inactive but it is extremely sensitive to pHi changes, being rapidly activated by small intracellular hydrogen concentration increases.	Hydrogen	145-153	glucose-6-phosphate isomerase	Homo sapiens	17-20
18661333-4	2008	At physiological pHi, NHE-1 is essentially inactive but it is extremely sensitive to pHi changes, being rapidly activated by small intracellular hydrogen concentration increases.	Hydrogen	145-153	glucose-6-phosphate isomerase	Homo sapiens	85-88
18041010-0	2008	1H and 13C NMR spectra of C-6 and C-9 substituted 3-azabicyclco[3.3.1]nonanes.	Hydrogen	0-2	complement C6	Homo sapiens	26-37
12925531-6	2003	Determination of the crystal structure of a complex of diclofenac with murine COX-2 demonstrates that diclofenac binds to COX-2 in an inverted conformation with its carboxylate group hydrogen-bonded to Tyr-385 and Ser-530.	Hydrogen	183-191	cytochrome c oxidase II, mitochondrial	Mus musculus	78-83
12925531-6	2003	Determination of the crystal structure of a complex of diclofenac with murine COX-2 demonstrates that diclofenac binds to COX-2 in an inverted conformation with its carboxylate group hydrogen-bonded to Tyr-385 and Ser-530.	Hydrogen	183-191	cytochrome c oxidase II, mitochondrial	Mus musculus	122-127
18005256-10	2007	The data obtained with other characteristic mutations suggested that these hydrogen bonds are conducive to the recruitment of phenol compounds by estrogen-related receptor gamma.	Hydrogen	75-83	estrogen related receptor gamma	Homo sapiens	146-177
12824064-3	2003	Conformational studies on the synthetic, 21-residue N-terminal extension peptide (Thr5-Lys25) of human aspartyl-tRNA synthetase using 1H nuclear magnetic resonance (NMR) spectroscopy, showed that the C-terminus adopts a regular alpha-helix with amphiphilicity, while the N-terminus shows a less-ordered structure with a flexible beta-turn.	Hydrogen	134-136	aspartyl-tRNA synthetase 1	Homo sapiens	103-127
18042461-4	2007	In both the "cavity insertion" (L3MBTL1) and "surface groove" (PHD finger) modes of methyllysine recognition, a carboxylate group both hydrogen bonds and ion pairs to the methylammonium proton.	Hydrogen	135-143	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	32-39
14632469-11	2003	The inferred active sites mapped out by the 4D-QSAR models suggest that hydrogen bond interactions are not prevalent when this class of P450 analogue inhibitors binds to the receptor active site.	Hydrogen	72-80	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	136-140
18225649-5	2007	According to the data on hydrogen exchange in the native RNase A molecule, the dynamic stability of the tertiary structure of domain II is lower than that of domain I because of the lesser amount of the internal bulky nonpolar residues Val, Ile, and Phe.	Hydrogen	25-33	ribonuclease A family member 1, pancreatic	Homo sapiens	57-64
14636463-5	2003	RESULTS: The RT-PCR showed that the levels of STAT1mRNA expression of the lung tissue in H1 1.25 +/- 0.12, H2 2.28 +/- 0.15 and H3 1.27 +/- 0.12 were significantly higher than that in the healthy control group 0.61 +/- 0.07 (P &lt; 0.01); the levels of STAT2mRNA expression in H1 0.54 +/- 0.06, H2 1.01 +/- 0.08 and H3 1.36 +/- 0.09 were significantly higher than that in control group 0.30 +/- 0.03 (P &lt; 0.01); the mRNA expressions of STAT3 in H1 0.74 +/- 0.11, H2 1.19 +/- 0.13 and H3 0.80 +/- 0.08 were significantly higher than that in control group 0.26 +/- 0.10 (P &lt; 0.01); and the mRNA expressions of STAT5 in H1 0.92 +/- 0.10, H2 1.23 +/- 0.10 and H3 1.03 +/- 0.11 were significantly higher than that in control group 0.60 +/- 0.11 (P &lt; 0.01).	Hydrogen	107-109	signal transducer and activator of transcription 1	Rattus norvegicus	46-51
14636463-5	2003	RESULTS: The RT-PCR showed that the levels of STAT1mRNA expression of the lung tissue in H1 1.25 +/- 0.12, H2 2.28 +/- 0.15 and H3 1.27 +/- 0.12 were significantly higher than that in the healthy control group 0.61 +/- 0.07 (P &lt; 0.01); the levels of STAT2mRNA expression in H1 0.54 +/- 0.06, H2 1.01 +/- 0.08 and H3 1.36 +/- 0.09 were significantly higher than that in control group 0.30 +/- 0.03 (P &lt; 0.01); the mRNA expressions of STAT3 in H1 0.74 +/- 0.11, H2 1.19 +/- 0.13 and H3 0.80 +/- 0.08 were significantly higher than that in control group 0.26 +/- 0.10 (P &lt; 0.01); and the mRNA expressions of STAT5 in H1 0.92 +/- 0.10, H2 1.23 +/- 0.10 and H3 1.03 +/- 0.11 were significantly higher than that in control group 0.60 +/- 0.11 (P &lt; 0.01).	Hydrogen	295-297	signal transducer and activator of transcription 1	Rattus norvegicus	46-51
14636463-6	2003	The Northern blot assay demonstrated that the expressions of STAT1mRNA in H1 0.49 +/- 0.10 and H3 0.67 +/- 0.07 were significantly different from that in H2 0.91 +/- 0.07 (P &lt; 0.01); the expressions of STAT3mRNA in H1 2.10 +/- 0.21 and H3 2.58 +/- 0.17 were significantly different from that in H1 3.56 +/- 0.29 (P &lt; 0.01); the expressions of STAT5mRNA in H1 0.99 +/- 0.10 and H3 1.45 +/- 0.12 were significantly different from that in H2 1.79 +/- 0.15 (P &lt; 0.01).	Hydrogen	154-156	signal transducer and activator of transcription 1	Rattus norvegicus	61-66
14636463-6	2003	The Northern blot assay demonstrated that the expressions of STAT1mRNA in H1 0.49 +/- 0.10 and H3 0.67 +/- 0.07 were significantly different from that in H2 0.91 +/- 0.07 (P &lt; 0.01); the expressions of STAT3mRNA in H1 2.10 +/- 0.21 and H3 2.58 +/- 0.17 were significantly different from that in H1 3.56 +/- 0.29 (P &lt; 0.01); the expressions of STAT5mRNA in H1 0.99 +/- 0.10 and H3 1.45 +/- 0.12 were significantly different from that in H2 1.79 +/- 0.15 (P &lt; 0.01).	Hydrogen	442-444	signal transducer and activator of transcription 1	Rattus norvegicus	61-66
18225649-7	2007	A common feature of the conformation of the flexible disordered backbone of all RNase A nonnative structures considered is the predominance of short PPII helices, which provides a high rate of the restoration of the native secondary and tertiary structures upon renaturation or self-organization and global fluctuations of the native structure revealed by the hydrogen exchange and proteolytic degradation.	Hydrogen	360-368	ribonuclease A family member 1, pancreatic	Homo sapiens	80-87
17604199-10	2007	With this model, a flexible docking study with the substrate and inhibitors was performed and the results indicated that Gly106 and Lys256 in OAT are the important determinant residues in binding as they have strong hydrogen bonding contacts with the substrate and inhibitors.	Hydrogen	216-224	ornithine aminotransferase	Homo sapiens	142-145
14519022-5	2003	The high-pressure infrared study suggests that the C(alpha)[bond]H- - -O hydrogen bonds are the important determinants for the stability of the PF(6)(-) salt.	Hydrogen	73-81	sperm associated antigen 17	Homo sapiens	144-152
17951433-9	2007	Because the Cyc6 promoter is also induced under anaerobic conditions, this system opens possibilities for sustained cycling hydrogen production.	Hydrogen	124-132	uncharacterized protein	Chlamydomonas reinhardtii	12-16
14511591-1	2003	A new pulse sequence, long-range CPMG-adjusted heteronuclear single quantum coherence (LR-CAHSQC), is proposed for the determination of long-range JCH coupling constants from a long-range 1H-13C correlation experiment.	Hydrogen	188-190	joining chain of multimeric IgA and IgM	Homo sapiens	147-150
17826792-5	2007	The aromatic ring of CAP-1 inserts into the cavity, with the urea NH groups forming hydrogen bonds with the backbone oxygen of Val59 and the dimethylamonium group interacting with the side-chains of Glu28 and Glu29.	Hydrogen	84-92	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	21-26
14706560-4	2003	Leptin was injected into the lateral ventricle (LV), the third ventricle (3V), or intraperitoneally (IP) once a day, 1h before the onset of the dark period.	Hydrogen	117-119	leptin	Rattus norvegicus	0-6
12957675-8	2003	Furthermore, 6 beta-hydroxy-[1 alpha,16,16,17 alpha-2H(4)]testosterone was synthesized by the UV irradiated autoxidation at C-6 position of 3-ethyl-3,5-dienol ether derivative of deuterium-labeled testosterone ([1 alpha,16,16,17 alpha-2H(4)]testosterone) obtained by using catalytic deuteration and hydrogen-deuterium exchange reactions.	Hydrogen	299-307	complement C6	Homo sapiens	124-127
17768618-6	2007	These organisms were identified as responsible for the dechlorination of cis-DCE to ethene in the PCE-dechlorinating consortia, operating together with the Desulfitobacterium as PCE-to-cis-DCE dehalogenating bacterium and with a Syntrophus species as potential hydrogen-producing partner in cultures with benzoate.	Hydrogen	261-269	24-dehydrocholesterol reductase	Homo sapiens	77-80
17768618-6	2007	These organisms were identified as responsible for the dechlorination of cis-DCE to ethene in the PCE-dechlorinating consortia, operating together with the Desulfitobacterium as PCE-to-cis-DCE dehalogenating bacterium and with a Syntrophus species as potential hydrogen-producing partner in cultures with benzoate.	Hydrogen	261-269	24-dehydrocholesterol reductase	Homo sapiens	189-192
18156791-4	2007	This predicted binding mode study of CR229 with CDK2 demonstrated that CR229 interacted effectively with the Leu83 and Glu81 residues in the ATP-binding pocket of CDK2 for the possible hydrogen bond formation.	Hydrogen	185-193	cyclin dependent kinase 2	Homo sapiens	48-52
12842861-11	2003	As a functional correlate of increased 11betaHSD-2 expression in colon, the GR-stimulated sodium-hydrogen exchanger NHE-3 was lowered by NaCl restriction.	Hydrogen	97-105	solute carrier family 9 member A3	Rattus norvegicus	116-121
12828982-3	2003	Salivary carbonic anhydrase VI (CA VI) probably protects the teeth by accelerating the neutralization of hydrogen ions in the enamel pellicle on dental surfaces.	Hydrogen	105-113	carbonic anhydrase 6	Homo sapiens	32-37
18156791-4	2007	This predicted binding mode study of CR229 with CDK2 demonstrated that CR229 interacted effectively with the Leu83 and Glu81 residues in the ATP-binding pocket of CDK2 for the possible hydrogen bond formation.	Hydrogen	185-193	cyclin dependent kinase 2	Homo sapiens	163-167
17696533-4	2007	Here, we explore several feasible low-energy pathways of the nucleotide transfer reaction of pol beta for correct (according to Watson-Crick hydrogen bonding) G:C basepairing versus the incorrect G:G case within a consistent theoretical framework.	Hydrogen	141-149	DNA polymerase beta	Homo sapiens	93-101
12860429-8	2003	In form I, an ethanol molecule located below the O-4-plane is well ordered because it hydrogen bonds to surrounding O-3[bond]H, O-6[bond]H groups of the symmetry-related beta-CD molecules.	Hydrogen	86-94	immunoglobulin kappa variable 1D-37 (non-functional)	Homo sapiens	49-52
12672474-4	2003	Thirty-three to forty-two percent more HS bound to the FGF-2 affinity gel in the presence of PF4 than with HS alone.	Hydrogen	39-41	platelet factor 4	Homo sapiens	93-96
12672474-7	2003	PF4 released at sites of angiogenesis may bind to angiogenic growth factors attached to endothelial cell surface HS to disrupt or prevent them from interacting with their signalling receptors.	Hydrogen	113-115	platelet factor 4	Homo sapiens	0-3
17713901-3	2007	Together with previous results, the current work shows a highly conserved water-involved hydrogen bonding (HB) network in both CDK2- and CDK5-indirubin combinations to complete information from the X-ray crystallography.	Hydrogen	89-97	cyclin dependent kinase 2	Homo sapiens	127-131
12797804-9	2003	On the basis of these findings, as well as supporting (1)H NMR spectroscopic studies, it is postulated that not only cavity size per se, but also the ability of the aryl portion of the strap to serve as a CH hydrogen bond donor site are important in regulating the observed anion affinities.	Hydrogen	208-216	serine/threonine kinase receptor associated protein	Homo sapiens	185-190
17640135-8	2007	These results provide a conclusive evidence that H(2) (+)-core H(6) (+) ions are generated in irradiated solid hydrogens.	Hydrogen	111-120	H6 family homeobox 1	Homo sapiens	63-67
12809220-1	2003	[Cu4(mu-dppm)4(mu4-eta1,eta2-C[triple bond]C-)]2+ has been shown by 31P and 1H NMR studies to undergo two fluxional processes in solution, the oscillation of the C[triple bond]C2- unit inside the copper rectangle and the flipping of the diphosphines, and this has been supported by DFT(B3LYP) calculations.	Hydrogen	76-78	DNA polymerase iota	Homo sapiens	24-28
12767239-0	2003	Identification of the internal axial ligand of HO2-cobalt(III)-bleomycin: 1H[15N] HSQC NMR investigation of bleomycin, deglycobleomycin, and their hydroperoxide-cobalt(III) complexes.	Hydrogen	74-76	heme oxygenase 2	Homo sapiens	47-50
12686552-7	2003	These water molecules make specific hydrogen bonds to the DNA bases, the DNA phosphate backbones, and several critical Smad3 residues.	Hydrogen	36-44	SMAD family member 3	Homo sapiens	119-124
12741842-2	2003	Using urea and TMAO separately and together, hydrogen exchange (HX) studies on RNase A at pH* 6.35 were used to investigate the basic tenets of the urea:TMAO paradigm.	Hydrogen	45-53	ribonuclease A family member 1, pancreatic	Homo sapiens	79-86
12475394-7	2003	These results support the hypothesis that the hydroxy group of the native VIP-Thr(11) side chain can indeed form a hydrogen bond with the Tyr side chain in the VPAC(2) receptor.	Hydrogen	115-123	vasoactive intestinal peptide receptor 2	Homo sapiens	160-167
12517147-9	2003	Structural comparison of TcAChE with rat AChE, as represented by the closely related mouse AChE structure (1maa.pdb), reveals a narrower gorge for rat AChE, a perpendicular alignment of the Tyr337 ring to the gorge axis, and its conformational rigidity, as a result of hydrogen bonding between its hydroxyl group and that of Tyr341, relative to TcAChE Phe330.	Hydrogen	269-277	acetylcholinesterase	Mus musculus	41-45
12522123-5	2003	We found that the activity of the Lbx1 promoter, as indicated by a LacZ reporter gene, is upregulated in the hearts of Lbx1(+/-):splotch(1H)/splotch(1H) and Lbx1(-/-) mice, indicating that Pax3 and Lbx1 participate in a negative regulatory feedback that might be necessary for normal differentiation and function of the myocardium during early heart development.	Hydrogen	137-139	ladybird homeobox 1	Mus musculus	34-38
12522123-5	2003	We found that the activity of the Lbx1 promoter, as indicated by a LacZ reporter gene, is upregulated in the hearts of Lbx1(+/-):splotch(1H)/splotch(1H) and Lbx1(-/-) mice, indicating that Pax3 and Lbx1 participate in a negative regulatory feedback that might be necessary for normal differentiation and function of the myocardium during early heart development.	Hydrogen	137-139	ladybird homeobox 1	Mus musculus	119-123
12522123-5	2003	We found that the activity of the Lbx1 promoter, as indicated by a LacZ reporter gene, is upregulated in the hearts of Lbx1(+/-):splotch(1H)/splotch(1H) and Lbx1(-/-) mice, indicating that Pax3 and Lbx1 participate in a negative regulatory feedback that might be necessary for normal differentiation and function of the myocardium during early heart development.	Hydrogen	137-139	ladybird homeobox 1	Mus musculus	119-123
12522123-5	2003	We found that the activity of the Lbx1 promoter, as indicated by a LacZ reporter gene, is upregulated in the hearts of Lbx1(+/-):splotch(1H)/splotch(1H) and Lbx1(-/-) mice, indicating that Pax3 and Lbx1 participate in a negative regulatory feedback that might be necessary for normal differentiation and function of the myocardium during early heart development.	Hydrogen	137-139	ladybird homeobox 1	Mus musculus	119-123
12522123-5	2003	We found that the activity of the Lbx1 promoter, as indicated by a LacZ reporter gene, is upregulated in the hearts of Lbx1(+/-):splotch(1H)/splotch(1H) and Lbx1(-/-) mice, indicating that Pax3 and Lbx1 participate in a negative regulatory feedback that might be necessary for normal differentiation and function of the myocardium during early heart development.	Hydrogen	149-151	ladybird homeobox 1	Mus musculus	34-38
12522123-5	2003	We found that the activity of the Lbx1 promoter, as indicated by a LacZ reporter gene, is upregulated in the hearts of Lbx1(+/-):splotch(1H)/splotch(1H) and Lbx1(-/-) mice, indicating that Pax3 and Lbx1 participate in a negative regulatory feedback that might be necessary for normal differentiation and function of the myocardium during early heart development.	Hydrogen	149-151	ladybird homeobox 1	Mus musculus	119-123
12522123-5	2003	We found that the activity of the Lbx1 promoter, as indicated by a LacZ reporter gene, is upregulated in the hearts of Lbx1(+/-):splotch(1H)/splotch(1H) and Lbx1(-/-) mice, indicating that Pax3 and Lbx1 participate in a negative regulatory feedback that might be necessary for normal differentiation and function of the myocardium during early heart development.	Hydrogen	149-151	ladybird homeobox 1	Mus musculus	119-123
12522123-5	2003	We found that the activity of the Lbx1 promoter, as indicated by a LacZ reporter gene, is upregulated in the hearts of Lbx1(+/-):splotch(1H)/splotch(1H) and Lbx1(-/-) mice, indicating that Pax3 and Lbx1 participate in a negative regulatory feedback that might be necessary for normal differentiation and function of the myocardium during early heart development.	Hydrogen	149-151	ladybird homeobox 1	Mus musculus	119-123
12526718-1	2003	A photoinduced hydrogen production system that couples sucrose degradation with invertase and glucose dehydrogenase (GDH) and hydrogen production with colloidal platinum as a catalyst using visible light-induced photosensitization of artificial Zn chlorophyll-a (Zn Chl-a) has been developed.	Hydrogen	15-23	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	94-115
12526718-1	2003	A photoinduced hydrogen production system that couples sucrose degradation with invertase and glucose dehydrogenase (GDH) and hydrogen production with colloidal platinum as a catalyst using visible light-induced photosensitization of artificial Zn chlorophyll-a (Zn Chl-a) has been developed.	Hydrogen	15-23	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	117-120
12526718-2	2003	Continuous hydrogen gas production over more than 240 min was observed when the reaction mixture containing sucrose, invertase, GDH, nicotinamide adenine dinucreotide (NAD(+)), Zn Chl-a, methyl viologen (MV(2+), an electron relay reagent), and colloidal platinum was irradiated by visible light.	Hydrogen	11-19	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	128-131
12646377-4	2003	Interpretation of the thermodynamic parameters in buffered solution of water, 30% glycerol and D(2)O leads to the conclusion that the highly specific binding of CsA to hCyp18 is mainly mediated through hydrogen bonding and to a lesser degree through hydrophobic interaction.	Hydrogen	202-210	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	161-164
12577990-5	2003	Throughout the text examples of the commonly observed NMR parameters , 1 / T1 and 1 / T2 are drawn from biological studies of 1H, 31P, 19F 15N (and other nuclei).	Hydrogen	126-128	interleukin 1 receptor like 1	Homo sapiens	75-83
12512027-6	2003	In G6PT1 deficiency, basal hydrogen concentrations were repeatedly found to be elevated.	Hydrogen	27-35	solute carrier family 37 member 4	Homo sapiens	3-8
12501179-5	2002	AICAR is bound at the dimer interface of the transformylase domains and forms an extensive hydrogen bonding network with a multitude of active site residues.	Hydrogen	91-99	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	0-5
12463747-0	2002	Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase.	Hydrogen	25-33	purine nucleoside phosphorylase	Bos taurus	88-119
12444134-4	2002	The comparison shows that while the receptor uses a common interface region to bind the three diverse ligands, each ligand forms a distinct, but overlapping, set of hydrogen bonds, hydrophobic interactions, and salt bridges, illustrating the underlying principle of NKG2D-ligand recognition being the conservation in overall shape complementarity and binding energy while permitting variation in ligand sequence through induced fit recognition.	Hydrogen	165-173	killer cell lectin like receptor K1	Homo sapiens	266-271
12444134-8	2002	Finally, a receptor-ligand recognition algorithm was developed to assist the identification of diverse NKG2D ligands based on evaluating the potential hydrogen bonds, hydrophobic interactions, and salt bridges at the receptor-ligand interface.	Hydrogen	151-159	killer cell lectin like receptor K1	Homo sapiens	103-108
12417200-0	2002	Phosphorylation driven motions in the COOH-terminal Src kinase, CSK, revealed through enhanced hydrogen-deuterium exchange and mass spectrometry (DXMS).	Hydrogen	95-103	C-terminal Src kinase	Homo sapiens	64-67
12417200-2	2002	We have employed enhanced methods of hydrogen-deuterium exchange-mass spectrometry (DXMS) to probe conformational changes on CSK in the absence and presence of nucleotides and thereby provide a structural framework for understanding phosphorylation-driven conformational changes.	Hydrogen	37-45	C-terminal Src kinase	Homo sapiens	125-128
12425666-3	2002	First, CDA existed in three types of structures in the polar solvent, DMAc; one is a single CDA chain, and the others are dynamic structures, or self-assemblies, which were formed temporarily and locally by the solvent-mediated hydrogen bonding between the intermolecular C-6 position hydroxyls of the anhydroglucose units in the CDA backbone.	Hydrogen	228-236	cytidine deaminase	Homo sapiens	7-10
12425666-7	2002	Here, the self-assemblies arise as the dynamical fluctuations under the spinodal decomposition situation and the competition between the hydrogen bonding (HB) and the hydrophobic interaction (HPhI) makes the conformation of CDA chains change drastically.	Hydrogen	137-145	cytidine deaminase	Homo sapiens	224-227
12825796-7	2002	According to our results, interactions with hydrogen acceptors and donors on the following residues can be utilised to achieve selectivity towards Tyk2: Y955, E1053, D1062 and S1063.	Hydrogen	44-52	tyrosine kinase 2	Homo sapiens	147-151
12398635-0	2002	Ferroelectricity and isotope effects in hydrogen-bonded KDP crystals.	Hydrogen	40-48	WNK lysine deficient protein kinase 1	Homo sapiens	56-59
12390682-9	2002	CONCLUSIONS: The overall structure of LIR-2 D1D2 resembles both LIR-1, and Killer Inhibitory Receptors, in that the A strand in each domain forms hydrogen bonds to both beta sheets, and there is a sharp angle between the two immunoglobulin-like domains.	Hydrogen	146-154	leukocyte immunoglobulin like receptor B2	Homo sapiens	38-43
8239497-8	1993	In spite of this different reactivity with Mabs, analysis by proton nuclear magnetic resonance (1H NMR) proved that carbohydrate structure of K-1 and H-2 were the same: NeuAc alpha 2--&gt;3Ga1 beta 1--&gt;4 [Fuc alpha 1--&gt;3] G1cNAc beta 1--&gt;3 Ga1 beta 1--&gt;4G1c beta 1--&gt;1Cer.	Hydrogen	96-98	keratin 1	Homo sapiens	142-153
7505589-0	1993	Human leucocyte elastase (HLE) preferentially cleaves the heavy chain H2 of inter-alpha-trypsin inhibitor (ITI).	Hydrogen	70-72	alpha-1-microglobulin/bikunin precursor	Homo sapiens	76-105
7505589-0	1993	Human leucocyte elastase (HLE) preferentially cleaves the heavy chain H2 of inter-alpha-trypsin inhibitor (ITI).	Hydrogen	70-72	alpha-1-microglobulin/bikunin precursor	Homo sapiens	107-110
7505589-6	1993	Our results demonstrate that the H2 heavy chain of ITI is particularly sensitive to HLE, and that early cleavage products (M(r)-values 120-150,000) consist of H1 linked to bikunin.	Hydrogen	33-35	alpha-1-microglobulin/bikunin precursor	Homo sapiens	51-54
8394123-4	1993	The acid stabilization of insulin"s conformation was attributed to the protonation of histidine at position 5 on the B-chain (HB5) as determined by 1H-NMR of the histidines, selective amino acid alteration, and enthalpies of ionization.	Hydrogen	148-150	keratin 85	Homo sapiens	126-129
7688668-1	1993	In previous studies, we determined that incubation of high concentrations of the 7.5% saline (HS) component of HSD with human blood, in vitro, significantly prolonged prothrombin time (PT), and reduced platelet aggregation.	Hydrogen	94-96	carbohydrate sulfotransferase 3	Homo sapiens	111-114
8518294-7	1993	Finally, changes in the 1H and 31P-NMR spectra of alpha A-crystallin and alpha B-crystallin in the presence of varying concentrations of urea are consistent with a two-domain model for alpha-crystallin subunits with the C-terminal domain being less stable and unfolding first in the presence of urea.	Hydrogen	24-26	crystallin alpha B	Bos taurus	73-91
8319679-10	1993	The C-6" and probably also the C-2" hydroxyl groups participate both as donors and as acceptors of two hydrogen bonds with neutral groups of the lectins.	Hydrogen	103-111	complement C6	Homo sapiens	4-7
8319679-11	1993	And finally, the C-6 hydroxyl group possibly acts as a donor of a weak hydrogen bond to a neutral group in RCA60, but not in RCA120.	Hydrogen	71-79	complement C6	Homo sapiens	17-20
8517874-6	1993	These data suggested that substitution of fluorines for hydrogens at C-26 and at C-27 positions may result in alteration in chemical reactivity and/or conformation of C-23, C-24 and C-25 positions of the 1,25-(OH)2D3 molecule.	Hydrogen	56-65	nucleolin	Homo sapiens	167-171
8495752-4	1993	These findings suggest that none of the cysteine residues in TnI are essential for the function of this protein and can be replaced to obtain a non-oxidizable mutant TnI which is much easier to handle and suitable as an alternative to the authentic TnI for various purposes, such as crystallization of TnI and the whole Tn, and 1H NMR studies.	Hydrogen	328-330	troponin I, fast skeletal muscle	Oryctolagus cuniculus	166-169
8495752-4	1993	These findings suggest that none of the cysteine residues in TnI are essential for the function of this protein and can be replaced to obtain a non-oxidizable mutant TnI which is much easier to handle and suitable as an alternative to the authentic TnI for various purposes, such as crystallization of TnI and the whole Tn, and 1H NMR studies.	Hydrogen	328-330	troponin I, fast skeletal muscle	Oryctolagus cuniculus	166-169
8495752-4	1993	These findings suggest that none of the cysteine residues in TnI are essential for the function of this protein and can be replaced to obtain a non-oxidizable mutant TnI which is much easier to handle and suitable as an alternative to the authentic TnI for various purposes, such as crystallization of TnI and the whole Tn, and 1H NMR studies.	Hydrogen	328-330	troponin I, fast skeletal muscle	Oryctolagus cuniculus	166-169
8448122-16	1993	The results suggest that the experimentally determined mucin peptide chain dimensions can be fully accounted for by short-range (+/- 3 residue) intramolecular steric and hydrogen bond interactions resulting from the clustering of glycosylated residues.	Hydrogen	170-178	LOC100508689	Homo sapiens	55-60
8381533-3	1993	Gas-phase compactness of the S-S cross-linked RNase A relative to denatured S-derivatized RNase A is indicated by exchange of 35 and 135 hydrogen atoms, respectively.	Hydrogen	137-145	ribonuclease A family member 1, pancreatic	Homo sapiens	46-53
8381533-3	1993	Gas-phase compactness of the S-S cross-linked RNase A relative to denatured S-derivatized RNase A is indicated by exchange of 35 and 135 hydrogen atoms, respectively.	Hydrogen	137-145	ribonuclease A family member 1, pancreatic	Homo sapiens	90-97
8482489-6	1993	These results suggest that it is possible to enhance the binding of the permanently charged trimethylammonium analog of chlorpromazine by the addition of a functional group near the quaternary nitrogen which is capable of forming a hydrogen bond with the D2 dopamine receptor.	Hydrogen	232-240	dopamine receptor D2	Homo sapiens	255-275
7678096-9	1993	The 1H nuclear magnetic resonance spectra of human II Ang and Ang II were determined both separately and when combined in the same cuvette.	Hydrogen	4-6	angiogenin	Homo sapiens	54-57
1435214-0	1992	Determination of absolute phosphate metabolite concentrations in RIF-1 tumors in vivo by 31P-1H-2H NMR spectroscopy using water as an internal intensity reference.	Hydrogen	93-95	replication timing regulatory factor 1	Homo sapiens	65-70
1452454-3	1992	1H-NMR, mass spectral and UV absorption spectral analyses of the major adducts formed by N-acetyoxy-PhIP with 2"-deoxyguanosine and with its phosphate esters indicated that PhIP bound at the C-8 position of guanine, as previously demonstrated with other heterocyclic amines.	Hydrogen	0-2	homeobox C8	Homo sapiens	191-194
1390715-4	1992	The Cys14----Ser mutant of glutaredoxin is shown to retain 38% of the GSH disulfide oxidoreductase activity of the wild-type protein with hydroxyethyl disulfide as substrate but to be completely inactive with ribonucleotide reductase, demonstrating that dithiol glutaredoxin is the hydrogen donor for ribonucleotide reductase.	Hydrogen	282-290	glutaredoxin	Homo sapiens	27-39
1446302-3	1992	The chemical shifts of the C-6 resonances are also sensitive to hydrogen-bonding interactions, as shown by the spectral changes on loss of water from the structures.	Hydrogen	64-72	complement C6	Homo sapiens	27-30
1509407-4	1992	Seven of 13 inhibitors that bound only to the fVIII light chain by immunoblotting also bound to fragment H2 in an immunoprecipitation assay.	Hydrogen	105-107	coagulation factor VIII	Homo sapiens	46-51
1373626-4	1992	This analysis considers the putative recognition features representative of common motif subsets shared with loop structures in CDR2 and FR3 regions of antibodies such as charge-2x-charge-x-charge or hydrogen bond donor (acceptor)-2x-charge-x-hydrogen bond donor (acceptor) type motifs, where x is any residue that can participate in maintaining a loop conformation.	Hydrogen	243-251	cerebellar degeneration related protein 2	Homo sapiens	128-132
1352136-1	1992	OBJECTIVE: To find out if there was a correlation between hydrogen, potassium stimulated ATPase (H,K-ATPase) activity and gastric acid secretion in patients with duodenal ulcers after proximal gastric vagotomy.	Hydrogen	58-66	dynein axonemal heavy chain 8	Homo sapiens	89-95
1734952-1	1992	The three-dimensional solution structure of native, intact porcine calbindin D9k has been determined by distance geometry and restrained molecular dynamics calculations using distance and dihedral angle constraints obtained from 1H NMR spectroscopy.	Hydrogen	229-231	S100 calcium binding protein G	Bos taurus	67-80
1631043-4	1992	Specific residues involved in hydrogen bonds or salt interactions with dithionite include His116 and His117 of the beta 2 subunit and Lys16 of the alpha 1 subunit of the adjacent hemoglobin molecule.	Hydrogen	30-38	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	115-121
1765163-1	1991	Ultraviolet resonance Raman spectra of solubilized connectin indicated the presence of beta-sheets and hydrogen-bonded irregular structures.	Hydrogen	103-111	titin	Homo sapiens	51-60
1718750-0	1991	1H-NMR conformational analysis of a high-affinity antigenic 11-residue peptide from the tryptophan synthase beta 2 subunit.	Hydrogen	0-2	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	108-114
1718750-1	1991	Two synthetic peptides from the beta 2 subunit of tryptophan synthase have been studied by 1H-NMR spectroscopy at 300 MHz.	Hydrogen	91-93	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	32-38
1887879-0	1991	Effects of calmodulin antagonists on hydrogen-translocating shuttles in perfused rat liver.	Hydrogen	37-45	calmodulin 1	Rattus norvegicus	11-21
1887879-1	1991	The effects of calmodulin antagonists on the capacity of hydrogen-translocating shuttles were studied in the perfused rat liver.	Hydrogen	57-65	calmodulin 1	Rattus norvegicus	15-25
12244298-4	2002	The increased potency arises primarily from the formation of two additional hydrogen bonds between the inhibitor and Asp 86 of CDK2, which facilitate optimum hydrophobic packing of the anilino group with the specificity surface of CDK2.	Hydrogen	76-84	cyclin dependent kinase 2	Homo sapiens	127-131
12244298-4	2002	The increased potency arises primarily from the formation of two additional hydrogen bonds between the inhibitor and Asp 86 of CDK2, which facilitate optimum hydrophobic packing of the anilino group with the specificity surface of CDK2.	Hydrogen	76-84	cyclin dependent kinase 2	Homo sapiens	231-235
17512540-6	2007	The parameter Phi(H/D), defined as the ratio of the effect of isotopic substitution upon the activation free energy to the equilibrium free energy was determined to be 0.6 in a D(2)O background and 0.75 in a H(2)O background, indicating that significant intraprotein hydrogen bond interactions are developed in the transition state for the folding of NTL9.	Hydrogen	267-275	glucose-6-phosphate isomerase	Homo sapiens	14-17
12230985-0	2002	Study of the coordination of amino acids with metals using [trans-en2Os(eta2-H2)L]2+ as a 1H NMR probe.	Hydrogen	90-92	DNA polymerase iota	Homo sapiens	72-76
1790297-4	1991	The Pro1-Pro2 peptide bond is cis and the molecular conformation is stabilized by an intramolecular hydrogen bond between the CO group of the beta-Ala5 and the NH of the Phe3 residue.	Hydrogen	100-108	dihydrolipoamide dehydrogenase	Homo sapiens	170-174
17331070-3	2007	Using a beta-1,2-mannosyltransferase, we synthesized a three-beta-1,2-linkage-containing mannoheptaose and used it as a reference oligosaccharide for 1H-NMR assignment.	Hydrogen	150-152	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	8-16
9906313-0	1991	Optical Stark shift spectroscopy: Measurement of the v=1 polarizability in H2.	Hydrogen	75-77	immunoglobulin kappa variable 1-5	Homo sapiens	53-56
2054346-4	1991	PF4 protein subunit association/dissociation equilibrium thermodynamic parameters have been derived by 1H NMR (500MHz) resonance line-fitting analysis of steady-state Y60 3,5 ring proton resonance monomer-dimer-tetramer populations as a function of temperature from 10 to 40 degrees C. Below 10 degrees C and above 40 degrees C, resonance broadening and overlap severely impaired analysis.	Hydrogen	103-105	platelet factor 4	Homo sapiens	0-3
12190488-2	2002	It is, however, not recognized that the same amount of N can also qualitatively alter the electronic behavior of hydrogen: First-principles calculations reveal that, in GaAsN, a H atom bonds to N and can act as a donor in its own right, whereas in GaAs and GaN, H is amphoteric, causing passivation instead.	Hydrogen	113-121	gigaxonin	Homo sapiens	257-260
12203316-10	2002	CPK models with a dimeric structure, in which two perylene molecules are held together by intermolecular hydrogen bonding with the perylene core shifted slightly with respect to one another, could account for the optical properties and the observation of the four different peaks in the (1)H NMR spectra in polar solvent.	Hydrogen	105-113	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	0-3
17331070-3	2007	Using a beta-1,2-mannosyltransferase, we synthesized a three-beta-1,2-linkage-containing mannoheptaose and used it as a reference oligosaccharide for 1H-NMR assignment.	Hydrogen	150-152	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	61-69
17331070-4	2007	On the basis of the results obtained, we derived an additivity rule for the 1H-NMR chemical shifts of the beta-1,2-linked mannose residues.	Hydrogen	76-78	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	106-114
12081486-4	2002	We have exploited the photolyzable CO compound of the ferrous heme of nNOS to produce light-induced CO photolysis difference spectra and to compare spectra after hydrogen/deuterium exchange.	Hydrogen	162-170	nitric oxide synthase 1	Homo sapiens	70-74
17350261-3	2007	An X-ray structure of a co-crystal of GSK-3beta and 3 (IC(50)=3nM) depicts the hydrogen bonding and hydrophobic interactions in the ATP-binding pocket of this serine/threonine protein kinase.	Hydrogen	79-87	glycogen synthase kinase 3 beta	Homo sapiens	38-53
12121148-1	2002	A photoinduced hydrogen production system, coupling sucrose degradation with invertase and glucose dehydrogenase (GDH) and hydrogen production with colloidal platinum as a catalyst using the visible light-induced photosensitization of Mg chlorophyll-a (Mg Chl-a), has been developed.	Hydrogen	15-23	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	91-112
12121148-1	2002	A photoinduced hydrogen production system, coupling sucrose degradation with invertase and glucose dehydrogenase (GDH) and hydrogen production with colloidal platinum as a catalyst using the visible light-induced photosensitization of Mg chlorophyll-a (Mg Chl-a), has been developed.	Hydrogen	15-23	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	114-117
12238589-1	2002	Residual dipolar couplings between 15N and 1H nuclear spins in HPr were used to determine the protein"s orientation in a medium of bicelles, oriented by a magnetic field.	Hydrogen	43-45	haptoglobin-related protein	Homo sapiens	63-66
12083287-10	2002	Lactase preparations are effective assessed by breath hydrogen analysis in asymptomatic individuals with lactase deficiency if the enzymes are given simultaneously with milk.	Hydrogen	54-62	lactase	Homo sapiens	0-7
1673952-5	1991	We used solution 1H and 15N nuclear magnetic resonance [NMR] spectroscopy to determine the secondary structure of an 83-amino-acid residue fragment of alpha 2 that contains the homeo domain homology.	Hydrogen	17-19	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	151-158
1654780-1	1991	The reaction of the Cu,Co derivative of bovine Cu,Zn superoxide dismutase with phenylglyoxal or butanedione, which are known to inactivate the enzyme by selectively binding to Arg 141, has been studied by 1H NMR.	Hydrogen	205-207	superoxide dismutase [Cu-Zn]	Bos taurus	47-73
2007134-3	1991	The major product, dynemicin H (C30H23NO9), was determined to be a C-8 hydrogen analogue of dynemicins L and N in which the enediyne core is aromatized.	Hydrogen	71-79	homeobox C8	Homo sapiens	67-70
17476405-1	2007	A unique nanocrystalline, mesoporous PdO-SnO(2) film exhibiting high sensitivity and selectivity to hydrogen gas at room temperature has been developed.	Hydrogen	100-108	strawberry notch homolog 1	Homo sapiens	41-44
11925245-7	2002	The rate increase appears to be caused by a combination of steric acceleration of C-N bond cleavage and a decrease in the ionization constant of 1H(+), K(a1), due to the electron-donating properties of the arylamino C-8 substituent.	Hydrogen	145-147	homeobox C8	Homo sapiens	216-219
17350650-3	2007	The structure of the crystalline hRI x RNase 1 complex was determined at a resolution of 1.95 A, revealing the formation of 19 intermolecular hydrogen bonds involving 13 residues of RNase 1.	Hydrogen	142-150	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	33-36
17350650-3	2007	The structure of the crystalline hRI x RNase 1 complex was determined at a resolution of 1.95 A, revealing the formation of 19 intermolecular hydrogen bonds involving 13 residues of RNase 1.	Hydrogen	142-150	ribonuclease A family member 1, pancreatic	Homo sapiens	39-46
12018486-0	2002	Backbone 1H, 13C, and 15N resonance assignments for the C-terminal region of Ku86 (Ku86CTR).	Hydrogen	9-11	X-ray repair cross complementing 5	Homo sapiens	77-81
17350650-4	2007	In contrast, only nine such hydrogen bonds are apparent in the structure of the complex between porcine RI and RNase A.	Hydrogen	28-36	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	104-106
17350650-4	2007	In contrast, only nine such hydrogen bonds are apparent in the structure of the complex between porcine RI and RNase A.	Hydrogen	28-36	ribonuclease A family member 1, pancreatic	Homo sapiens	111-118
17371021-1	2007	We present a novel series of hydrogen-bonded, polycrystalline 1:1 complexes of Schiff base models of the cofactor pyridoxal-5"-phosphate (PLP) with carboxylic acids that mimic the cofactor in a variety of enzyme active sites.	Hydrogen	29-37	pyridoxal phosphatase	Homo sapiens	138-141
12062378-0	2002	Hydrogen and deuterium in myoglobin as seen by a neutron structure determination at 1.5 A resolution.	Hydrogen	0-8	myoglobin	Physeter catodon	26-35
11902862-4	2002	Here we provide evidence for the role of AdoMet as a reversible deoxyadenosyl radical generator, which initiates repair by hydrogen atom abstraction from C-6 of SP.	Hydrogen	123-131	complement C6	Homo sapiens	154-157
17371021-6	2007	When the Schiff base nitrogen atoms of the adducts carry an aliphatic substituent such as in the internal and external aldimines of PLP in the enzymatic environment, protonation of the ring nitrogen shifts the proton in the intramolecular OHN hydrogen bond from the oxygen to the Schiff base nitrogen.	Hydrogen	243-251	pyridoxal phosphatase	Homo sapiens	132-135
17346042-5	2007	This novel phenomenon is attributed to the preferential formation of the energetic favorable configurations with both the C-H...O weak hydrogen bonds and the pi-stacking of the two moieties of each SP6 molecule.	Hydrogen	135-143	Sp6 transcription factor	Homo sapiens	198-201
11839084-3	2002	A radical produced by the net gain of a hydrogen atom at C6 and a proton at N3, Cyt(C6+H, N3+H(+))(+*), is identified.	Hydrogen	40-48	complement C6	Homo sapiens	80-86
11883786-0	2002	1H, 13C and 15N resonance assignments for the perdeuterated 22 kD palm-thumb domain of DNA polymerase beta.	Hydrogen	0-2	DNA polymerase beta	Homo sapiens	87-106
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM &lt; IC50 &lt; 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Hydrogen	221-229	hemoglobin subunit alpha 2	Homo sapiens	210-214
17126018-3	2007	These studies also suggested that the addition of substituents to the 7-position of 11 that are capable of forming hydrogen bonds to the enzyme could lead to compounds (14-18) having enhanced PNMT inhibitory potency.	Hydrogen	115-123	phenylethanolamine N-methyltransferase	Homo sapiens	192-196
11801070-1	2002	Phase transition temperatures of hydrogen-bonded ferroelectrics DKDP ( KD2PO4) and KDP ( KH2PO4) vanish at pressure p larger than respective critical pressures p(c).	Hydrogen	33-41	WNK lysine deficient protein kinase 1	Homo sapiens	65-68
17297264-0	2007	Neuroprotective effects of growth hormone against hypoxic-ischemic brain injury in neonatal rats: 1H magnetic resonance spectroscopic study.	Hydrogen	98-100	gonadotropin releasing hormone receptor	Rattus norvegicus	27-41
12751910-4	2002	Quantitative Structure-Activity Relationships (QSARs) for substrates binding to CYP2B6 indicate a key role for hydrogen bonding, and lipophilic character, as determined by the log P parameter (where P is the octanol/water partition coefficient), is also of importance for explaining the variation in experimental binding affinity for CYP2B6 substrates.	Hydrogen	111-119	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	80-86
17484143-7	2007	FTIR, together with TGA, suggested molecular interactions (hydrogen-bonding) in the SDs.	Hydrogen	59-67	T-box transcription factor 1	Homo sapiens	20-23
11912930-5	2002	The active site of MnSOD is dominated by a hydrogen bond network comprising the manganese-bound aqueous ligand, the side chains of four residues (Gln-143, Tyr-34, His-30, and Tyr-166 from an adjacent subunit), as well as other water molecules.	Hydrogen	43-51	superoxide dismutase 2	Homo sapiens	19-24
17046812-0	2006	Mapping ERK2-MKP3 binding interfaces by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	40-48	dual specificity phosphatase 6	Homo sapiens	13-17
29712139-3	2001	An ionic mechanism is proposed that involves the dihydrogen complex [Cp*Ru(CO)2 (eta2 -H2 )]+ .	Hydrogen	49-59	DNA polymerase iota	Homo sapiens	81-85
17147394-0	2006	Solution chemistry of a water-soluble eta2-H2 ruthenium complex: evidence for coordinated H2 acting as a hydrogen bond donor.	Hydrogen	43-45	DNA polymerase iota	Homo sapiens	38-42
11479310-3	2001	We hypothesized that the NO reactivity is in part controlled by hydrogen bonding between the conserved tryptophan residue (position 409 in the neuronal isoform of NOS (nNOS)) and the cysteine residue that forms the proximal bond to the heme.	Hydrogen	64-72	nitric oxide synthase 1	Homo sapiens	168-172
17147394-0	2006	Solution chemistry of a water-soluble eta2-H2 ruthenium complex: evidence for coordinated H2 acting as a hydrogen bond donor.	Hydrogen	105-113	DNA polymerase iota	Homo sapiens	38-42
11710007-5	2001	The optimum conditions for phthalimido group deprotection are studied to generate a unique product with a hydrophobic chain attached mainly at the hydroxyl group (C-6 and/or C-3) while the amino group (C-2) is retained as characterized by FT-IR and 1H NMR.	Hydrogen	249-251	complement C6	Homo sapiens	163-166
17147394-1	2006	The ability of an eta2-H2 ligand to participate in intermolecular hydrogen bonding in solution has long been an unresolved issue.	Hydrogen	66-74	DNA polymerase iota	Homo sapiens	18-22
17147394-3	2006	We present the synthesis of several new water-soluble ruthenium coordination complexes including an eta2-H2 complex that is surprisingly inert to substitution by water.	Hydrogen	105-107	DNA polymerase iota	Homo sapiens	100-104
17220082-10	2006	Assuming that carbaryl would interact with the AhR through a hydrogen bond, this interaction was studied computationally using hydrogen fluoride as a model H-bond donor.	Hydrogen	61-69	aryl hydrocarbon receptor	Homo sapiens	47-50
11545585-8	2001	Three hydrogen bonds between CaM and the peptide (E87-R336, E87-T339 and K75-T339) along with two salt bridges (E11-R349 and E114-K334) are the most probable determinants for the binding direction of the CaMKK peptide to CaM.	Hydrogen	6-14	calmodulin 1	Rattus norvegicus	29-32
16953504-7	2006	A second isomer of [(MBT)Zn(4)O(4)] with a strong O--HN hydrogen bond rather than a Zn--N bond is only slightly less stable (binding energy -243 kJ mol(-1)).	Hydrogen	56-64	proteinase 3	Homo sapiens	21-24
11434773-2	2001	Hydrogen/deuterium (H/D) exchange into amide bonds, quantitated by on-line HPLC and mass spectrometry, has been used to compare the dynamic and conformational properties of human HGPRT alone, the HGPRT-GMP-Mg(2+) complex, the HGPRT-IMP-MgPPi &lt;==&gt; HGPRT-Hx-MgPRPP equilibrating mixture, and the transition-state analogue complex HGPRT-ImmGP-MgPPi.	Hydrogen	0-8	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	196-201
11434773-2	2001	Hydrogen/deuterium (H/D) exchange into amide bonds, quantitated by on-line HPLC and mass spectrometry, has been used to compare the dynamic and conformational properties of human HGPRT alone, the HGPRT-GMP-Mg(2+) complex, the HGPRT-IMP-MgPPi &lt;==&gt; HGPRT-Hx-MgPRPP equilibrating mixture, and the transition-state analogue complex HGPRT-ImmGP-MgPPi.	Hydrogen	0-8	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	196-201
11434773-2	2001	Hydrogen/deuterium (H/D) exchange into amide bonds, quantitated by on-line HPLC and mass spectrometry, has been used to compare the dynamic and conformational properties of human HGPRT alone, the HGPRT-GMP-Mg(2+) complex, the HGPRT-IMP-MgPPi &lt;==&gt; HGPRT-Hx-MgPRPP equilibrating mixture, and the transition-state analogue complex HGPRT-ImmGP-MgPPi.	Hydrogen	0-8	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	196-201
16875839-1	2006	Proteins that undergo cooperative unfolding events display EX1 kinetic signatures in hydrogen exchange mass spectra.	Hydrogen	85-93	FERM domain containing 6	Homo sapiens	59-62
11525332-3	2001	We used positron emission tomography (PET) with the tracer H2(15O) to measure rCBF in 22 healthy volunteers.	Hydrogen	59-61	CCAAT/enhancer binding protein zeta	Rattus norvegicus	78-82
1845766-2	1991	Cerebral oxygenation was determined by measuring relative changes in the oxidation/reduction level of cytochrome aa3 and CBF was measured by the washout of H2.	Hydrogen	156-158	CCAAT/enhancer binding protein zeta	Rattus norvegicus	121-124
2074532-4	1990	The amide carbonyl oxygen at 6-position is considered to coordinate with the reagent, because the largest downfield shifts were observed at the amide carbonyl carbon (C-6) in 13C-NMR and the amide hydrogen (H-7) in 1H-NMR.	Hydrogen	197-205	complement C6	Homo sapiens	167-170
16979657-0	2006	Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry.	Hydrogen	64-72	S-phase kinase associated protein 2	Homo sapiens	35-39
2074532-4	1990	The amide carbonyl oxygen at 6-position is considered to coordinate with the reagent, because the largest downfield shifts were observed at the amide carbonyl carbon (C-6) in 13C-NMR and the amide hydrogen (H-7) in 1H-NMR.	Hydrogen	215-217	complement C6	Homo sapiens	167-170
2214759-2	1990	The results obtained under equilibrium conditions support the hypothesis of the additivity of the energies corresponding to each of the hydrogen-bond type interactions of di- or tri-hydroxylated TPEs with the estradiol binding site of ER and strongly suggest that, whichever ring is hydroxylated, the orientation of the TPE in the steroid binding site is always the same.	Hydrogen	136-144	estrogen receptor 1	Bos taurus	235-237
11430759-2	2001	Rotational diffusion tensors were calculated for a complex between MBP and beta-cyclodextrin using backbone 15N T1 and T1rho relaxation times and steady state 1H-15N NOE values.	Hydrogen	159-161	myelin basic protein	Homo sapiens	67-70
11430761-0	2001	Assignment of 1H, 15N and 13C resonances of the carbohydrate recognition domain of human galectin-3.	Hydrogen	14-16	galectin 3	Homo sapiens	89-99
16979657-6	2006	We find that Skp2 interacts with a localised region of Cks1 but the interaction causes a global change in the hydrogen exchange behaviour of Cks1.	Hydrogen	110-118	S-phase kinase associated protein 2	Homo sapiens	13-17
17047753-2	2006	All three oxygen species form very weak complexes with toluene and all also appear capable of abstracting a benzylic hydrogen atom to form the HO2 radical.	Hydrogen	117-125	heme oxygenase 2	Homo sapiens	143-146
11241218-3	2001	Peptide VIII adopts a well-defined beta-hairpin conformation in solvents capable of hydrogen bonding like (CD(3))(2)SO and CD(3)OH.	Hydrogen	84-92	cytochrome c oxidase subunit 8A	Homo sapiens	8-12
2207078-1	1990	Sequence-specific 1H NMR assignments are reported for the active L-tryptophan-bound form of Escherichia coli trp repressor.	Hydrogen	18-20	repressor	Escherichia coli	113-122
17014080-12	2006	Thus, in this case, the coupling between the production of AdoCH(2)(*) and its reaction with the hydrogen at C-6 and C-9 of DTB is less efficient than that in the wild type, probably because of geometry"s perturbation within the active site.	Hydrogen	97-105	complement C6	Homo sapiens	109-112
2194794-1	1990	Anion binding to yeast phosphoglycerate kinase has been investigated using 1H-NMR spectroscopy.	Hydrogen	75-77	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	23-46
11294629-4	2001	The 2.2 A resolution X-ray structure of H30A-MnSOD shows that removing the Tyr174--&gt;His30 hydrogen bond from the acceptor side results in a significant displacement of the main-chain segment containing the Y174 residue, with local rearrangement of the protein.	Hydrogen	93-101	superoxide dismutase 2	Homo sapiens	45-50
11294629-5	2001	The 1.35 A resolution structure of Y174F-MnSOD shows that disruption of the same hydrogen bond from the donor side has much greater consequences, with reorientation of F174 having a domino effect on the neighboring residues, resulting in a major rearrangement of the dimer interface and flipping of the His30 ring.	Hydrogen	81-89	superoxide dismutase 2	Homo sapiens	41-46
16952251-2	2006	GaN(0001) surfaces exposed to a hydrogen plasma will react with organic molecules bearing an alkene (C=C) group when illuminated with 254 nm light.	Hydrogen	32-40	gigaxonin	Homo sapiens	0-3
11258952-6	2001	Tertiary structure modifications induced by Ca2+ and XIP were analyzed by monitoring the hydrogen/deuterium exchange rate for the reconstituted exchanger.	Hydrogen	89-97	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	53-56
2158826-0	1990	Synthesis and conformational studies by 1H- and 13C-NMR spectroscopy of a novel, sterically constrained analogue of thyrotropin-releasing hormone.	Hydrogen	40-42	thyrotropin releasing hormone	Homo sapiens	116-145
20504597-3	1990	(1) The postulated existence of protein lipid hydrogen bonding has previously been demonstrated for glucose-6-phosphatase and for protein kinase C. (2) The prediction that changes in the H-bonding part of an anesthetic may influence its potency, but changes in the lipophilic part should not, can be verified.	Hydrogen	46-54	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	100-121
16840788-10	2006	Our data are consistent with a model in which an increased capability for hydrogen bonding in critical amino acids that reside in the C terminus of rCNT2 contributes to its enhanced selectivity for 2CdA.	Hydrogen	74-82	solute carrier family 28 member 2	Rattus norvegicus	148-153
33033273-6	2020	A broken gap band alignment for the SnO/PbO heterojunction is calculated, which can be attractive for energy conversion in solar cells, photocatalysis and hydrogen generation.	Hydrogen	155-163	strawberry notch homolog 1	Homo sapiens	36-39
11256818-0	2001	1H, 13C and 15N resonance assignments of the ERK2 binding domain of the MAPK phosphatase MKP-3.	Hydrogen	0-2	dual specificity phosphatase 6	Homo sapiens	89-94
16933926-4	2006	Both ((iPr)PNP)FeH2(N2) and ((iPr)PNP)FeH(SiH2Ph)N2 form eta2-dihydrogen complexes upon exposure to H2.	Hydrogen	17-19	DNA polymerase iota	Homo sapiens	57-61
11160999-4	2001	The third blood pressure QTL (QTL region 2) was close to the centromere between 1p11 and 1q12, which includes the candidate gene Slc9a3 for sodium/hydrogen exchange.	Hydrogen	147-155	solute carrier family 9 member A3	Rattus norvegicus	129-135
24597655-3	2015	Both global depletion of H2 S by cystathionine gamma-lyase (CSE) gene deletion and low levels of exogenous H2 S cause hypertension.	Hydrogen	25-27	cystathionine gamma-lyase	Rattus norvegicus	33-58
24597655-3	2015	Both global depletion of H2 S by cystathionine gamma-lyase (CSE) gene deletion and low levels of exogenous H2 S cause hypertension.	Hydrogen	25-27	cystathionine gamma-lyase	Rattus norvegicus	60-63
12147223-4	2002	CML-BSA also stimulated DNA-binding activity of activator protein-1 (AP-1) within 3h, but the stimulatory effect decreased in 5h, and nuclear factor-kappaB (NF-kappaB) with a peak activity at 1h and the stimulatory effect diminished in 3h.	Hydrogen	192-194	jun proto-oncogene	Mus musculus	48-67
12147223-4	2002	CML-BSA also stimulated DNA-binding activity of activator protein-1 (AP-1) within 3h, but the stimulatory effect decreased in 5h, and nuclear factor-kappaB (NF-kappaB) with a peak activity at 1h and the stimulatory effect diminished in 3h.	Hydrogen	192-194	jun proto-oncogene	Mus musculus	69-73
11688686-5	2001	The results showed that redox processes with nitrate, manganese oxide and ferric iron as the electron acceptors exhibited hydrogen threshold values close to PCE/TCE dechlorination, whereas cis-DCE and VC dechlorinations exhibited hydrogen threshold values in the range of sulfate reduction and methanogenesis, respectively.	Hydrogen	230-238	24-dehydrocholesterol reductase	Homo sapiens	193-196
16804678-5	2006	The detailed hydrogen-bonding geometries depicted in the active site of nNOS structures indicate that it is the ordered active-site water molecule rather than the substrate itself that would most likely serve as a direct proton donor to the diatomic ligands (CO, NO, as well as O(2)) bound to the heme.	Hydrogen	13-21	nitric oxide synthase 1	Homo sapiens	72-76
11688686-6	2001	Characteristic hydrogen concentrations for various redox processes were as follows (nM): denitrification, 0.1-0.4; manganese reduction, 0.1-2.0; iron reduction, 0.1-0.4; sulfate reduction, 1.5-4.5; methanogenesis, 2.5-24; PCE/TCE dechlorination, 0.6-0.9; eis-DCE dechlorination, 0.1-2.5; and VC dechlorination, 2-24.	Hydrogen	15-23	24-dehydrocholesterol reductase	Homo sapiens	259-262
34913508-6	2022	We also integrated steered molecular dynamics simulations and mutagenesis to reveal force-induced rotational conformational changes of MICA, involving formation of additional hydrogen bonds on its binding interface with NKG2D, impeding MICA dissociation under force.	Hydrogen	175-183	MHC class I polypeptide-related sequence A	Homo sapiens	135-139
34913508-6	2022	We also integrated steered molecular dynamics simulations and mutagenesis to reveal force-induced rotational conformational changes of MICA, involving formation of additional hydrogen bonds on its binding interface with NKG2D, impeding MICA dissociation under force.	Hydrogen	175-183	killer cell lectin like receptor K1	Homo sapiens	220-225
34913508-6	2022	We also integrated steered molecular dynamics simulations and mutagenesis to reveal force-induced rotational conformational changes of MICA, involving formation of additional hydrogen bonds on its binding interface with NKG2D, impeding MICA dissociation under force.	Hydrogen	175-183	MHC class I polypeptide-related sequence A	Homo sapiens	236-240
11357626-0	2001	Kinetics of conformational fluctuations by EX1 hydrogen exchange in native proteins.	Hydrogen	47-55	FERM domain containing 6	Homo sapiens	43-46
16914729-0	2006	Role of hoogsteen edge hydrogen bonding at template purines in nucleotide incorporation by human DNA polymerase iota.	Hydrogen	23-31	DNA polymerase iota	Homo sapiens	97-116
34530187-0	2022	Construction 0D/2D heterojunction by highly dispersed Ag2S quantum dots (QDs) loaded on the g-C3N4 nanosheets for photocatalytic hydrogen evolution.	Hydrogen	129-137	angiotensin II receptor type 1	Homo sapiens	54-58
17080657-5	2006	Cyclin D1-positive cells started to increase in the boundary of the brain contusion in the 1h group.	Hydrogen	91-93	cyclin D1	Homo sapiens	0-9
34530187-4	2022	The Ag2S QDs/g-C3N4 composite with 0.5 wt% Ag2S QDs loading achieved the highest hydrogen evolution rate of 471.1 mumol g-1 h-1 with an apparent quantum efficiency (AQE) of 1.48% at 405 nm.	Hydrogen	81-89	angiotensin II receptor type 1	Homo sapiens	4-8
34530187-4	2022	The Ag2S QDs/g-C3N4 composite with 0.5 wt% Ag2S QDs loading achieved the highest hydrogen evolution rate of 471.1 mumol g-1 h-1 with an apparent quantum efficiency (AQE) of 1.48% at 405 nm.	Hydrogen	81-89	angiotensin II receptor type 1	Homo sapiens	43-47
34530187-5	2022	Such remarkable hydrogen evolution activity far exceeded that of undoped g-C3N4 and Ag2S nanoparticles (NPs)/g-C3N4.	Hydrogen	16-24	angiotensin II receptor type 1	Homo sapiens	84-88
34583044-2	2022	In this report, a novel three-dimensional (3D) hierarchical hollow tubular g-C3N4/ZnIn2S4 nanosheets (HTCN/ZIS) type-II heterojunction photocatalyst was successfully prepared and applied for photocatalytic hydrogen production under visible light irradiation.	Hydrogen	206-214	zinc finger RANBP2-type containing 2	Homo sapiens	107-110
21423825-4	2000	Lys41 of RNase A is known to donate a hydrogen bond to a nonbridging phosphoryl oxygen in the transition state during catalysis.	Hydrogen	38-46	ribonuclease A family member 1, pancreatic	Homo sapiens	9-16
10845918-3	2000	Subsets of Ly-49A and Ly-49G2 NK share specificity for the same MHC class 1 ligand, D(d), binding of which results in an inhibitory signal to the NK cell but allows them to lyse H2(b) targets in vitro.	Hydrogen	178-180	killer cell lectin-like receptor, subfamily A, member 7	Mus musculus	22-29
10841807-3	2000	In this work, models have been constructed considering some implicit water molecules, placed in the position suggested by GRID, that participate in the dynamic hydrogen-bonding network at the polar active site entrance together with protein residues 355, 524, 120, and 513.	Hydrogen	160-168	GRB2 related adaptor protein 2	Homo sapiens	122-126
10909868-3	2000	between the hydrogen acceptor side chain carboxylate carbon 13CO2delta of glutamate 54 and the hydrogen donor backbone amide 15N of methionine 49 in a 12 kDa protein, human FKBP12, is detected via the trans-hydrogen bond 3hJ(NCO2delta) coupling by employing a novel sensitivity-enhanced HNCO-type experiment, CPD-HNCO.	Hydrogen	12-20	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	173-179
10909868-3	2000	between the hydrogen acceptor side chain carboxylate carbon 13CO2delta of glutamate 54 and the hydrogen donor backbone amide 15N of methionine 49 in a 12 kDa protein, human FKBP12, is detected via the trans-hydrogen bond 3hJ(NCO2delta) coupling by employing a novel sensitivity-enhanced HNCO-type experiment, CPD-HNCO.	Hydrogen	95-103	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	173-179
10909868-3	2000	between the hydrogen acceptor side chain carboxylate carbon 13CO2delta of glutamate 54 and the hydrogen donor backbone amide 15N of methionine 49 in a 12 kDa protein, human FKBP12, is detected via the trans-hydrogen bond 3hJ(NCO2delta) coupling by employing a novel sensitivity-enhanced HNCO-type experiment, CPD-HNCO.	Hydrogen	95-103	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	173-179
10909870-0	2000	1H, 13C and 15N resonance assignments for a truncated and inhibited catalytic domain of matrix metalloproteinase-2.	Hydrogen	0-2	matrix metallopeptidase 2	Homo sapiens	88-114
34774546-1	2022	In this work, new thiosemicarbazides (ECA-1, ECA-2) and their Cu (II) complexes (ECA-1-Cu, ECA-2-Cu) were synthesized and their structures were characterized by 1H NMR, 13C NMR, FT-IR, LC-MS, UV-Vis, and thermogravimetric analysis methods.	Hydrogen	161-163	ECA1	Homo sapiens	38-43
16840815-8	2006	Compound (VIII) (C(13)H(8)ClN(3)O, triclinic P1 with Z" = 2), where X = CN, forms a complex three-dimensional framework by N-H...N, C-H...N and C-H...O hydrogen bonds and two independent aromatic pi...pi stacking interactions.	Hydrogen	152-160	cytochrome c oxidase subunit 8A	Homo sapiens	10-14
16841981-1	2006	The 1H,19F HOESY spectra of the title compounds in CD2Cl2 solution indicate that the cluster cations form ion pairs with the BF4- and PF6- anions with a well-defined interionic structure that appears to be basically determined essentially by the nature of the X- ligand.	Hydrogen	4-6	sperm associated antigen 17	Homo sapiens	134-137
34915409-5	2022	The higher binding affinity of the E484K mutant is caused due to the formation of additional hydrogen bond and salt-bridge interactions with ACE2.	Hydrogen	93-101	angiotensin converting enzyme 2	Homo sapiens	141-145
10909872-0	2000	Sequence-specific 1H, 15N and 13C resonance assignments of the EEA1 FYVE domain.	Hydrogen	18-20	early endosome antigen 1	Homo sapiens	63-67
16819831-5	2006	We have determined that the association between the FMRP RGG box and Sc1 RNA is dominated by hydrophobic and hydrogen bond interactions, with minor contributions from electrostatic interactions, and that the FMRP RGG box binding increases the stability of the G quartet RNA structure significantly.	Hydrogen	109-117	transcription factor 19	Homo sapiens	69-72
16769893-7	2006	Furthermore, the ET rate from NADPH/CPR to the composite is 3.5-fold faster than that of Fe(Schiff-base).HO, although the redox potential of Fe(10-CH(2)CH(2)COOH-Schiff-base).HO (-79 mV vs. NHE) is lower than that of Fe(Schiff-base).HO (+15 mV vs. NHE), where NHE is normal hydrogen electrode.	Hydrogen	274-282	solute carrier family 9 member C1	Homo sapiens	248-251
10863936-1	2000	A bicyclic decapeptide, GCN4brM1, which was designed to be a helix-locked analog of the DNA-binding basic region from the yeast transcription factor GCN4, was synthesized and characterized using circular dichroism (CD) spectropolarimetry and 1H-NMR.	Hydrogen	242-244	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	24-28
16769893-7	2006	Furthermore, the ET rate from NADPH/CPR to the composite is 3.5-fold faster than that of Fe(Schiff-base).HO, although the redox potential of Fe(10-CH(2)CH(2)COOH-Schiff-base).HO (-79 mV vs. NHE) is lower than that of Fe(Schiff-base).HO (+15 mV vs. NHE), where NHE is normal hydrogen electrode.	Hydrogen	274-282	solute carrier family 9 member C1	Homo sapiens	248-251
16473871-12	2006	The 3D template also suggested the position of a residue, which could be involved in a hydrogen bond with CYP17 substrates and the shape and location of a cavity.	Hydrogen	87-95	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	106-111
10805137-0	2000	Sequence-specific 1H, 15N and 13C resonance assignments of the inhibitory prodomain of human furin.	Hydrogen	18-20	furin, paired basic amino acid cleaving enzyme	Homo sapiens	93-98
10805138-0	2000	Assignment of the 1H, 13C and 15N resonances of the C-terminal EF-hands of alpha-actinin in a 14 kDa complex with Z-repeat 7 of titin.	Hydrogen	18-20	titin	Homo sapiens	128-133
34960255-1	2021	We observe that a residue R of the spike glycoprotein of SARS-CoV-2 that has mutated in one or more of the current variants of concern or interest, or under monitoring, rarely participates in a backbone hydrogen bond if R lies in the S1 subunit and usually participates in one if R lies in the S2 subunit.	Hydrogen	203-211	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	35-40
16513268-5	2006	We found that phosphorylation at Y1105, a major tyrosine phosphorylation site on p190 RhoGAP, is decreased 1h after the conditioning in the hippocampus of wild-type mice, but not of Ptprz-deficient mice.	Hydrogen	107-109	Rho GTPase activating protein 35	Mus musculus	81-92
34898005-4	2022	With the VLi percentage of  1.6%, the Li2- x CuO2 catalyst exhibits a high Faradaic efficiency of 90.6 +- 7.6% for C2+ at -0.85 V versus reversible hydrogen electrode without iR correction, and an outstanding partial current density of -706 +- 32 mA cm-2 .	Hydrogen	148-156	ATP binding cassette subfamily A member 12	Homo sapiens	38-41
11150743-6	2000	This review will discuss strategies directed at oxygen-derived free radicals, neutrophils, adenosine, and the sodium-hydrogen exchanger (NHE).	Hydrogen	117-125	solute carrier family 9 member C1	Homo sapiens	137-140
10723998-0	2000	Sequence-specific 1H and 15N assignment and secondary structure of transforming growth factor beta3.	Hydrogen	18-20	transforming growth factor beta 3	Homo sapiens	67-99
34864923-6	2021	Degradation products, DP-1 and DP-2, were isolated and characterized by ESI-MS, 1H, NMR and 13C NMR spectroscopy.	Hydrogen	80-82	prostaglandin D2 receptor	Homo sapiens	22-26
16669651-5	2006	The crystal structure of this inhibitor bound to CDK2/cyclin A was determined and shows an unusual network of hydrogen bonds.	Hydrogen	110-118	cyclin dependent kinase 2	Homo sapiens	49-53
10652248-3	2000	We now show that HS, 4-CP, and staurosporine (ST) induce the release of cytochrome c from mitochondria with kinetics suggesting a causal relationship with the activation of caspase-3 and caspase-2.	Hydrogen	17-19	caspase 2	Mus musculus	187-196
16446384-9	2006	Two hCNT3 pharmacophore models revealed the minimal features required for hCNT3 transport as two hydrogen bond acceptors at 3"-OH and 5"-O and the hydrophobic center occupied by the base ring.	Hydrogen	97-105	solute carrier family 28 member 3	Homo sapiens	4-9
10739261-0	2000	Amide proton hydrogen exchange rates for sperm whale myoglobin obtained from 15N-1H NMR spectra.	Hydrogen	13-21	myoglobin	Physeter catodon	53-62
10739261-0	2000	Amide proton hydrogen exchange rates for sperm whale myoglobin obtained from 15N-1H NMR spectra.	Hydrogen	81-83	myoglobin	Physeter catodon	53-62
10739261-2	2000	The positions and exchange rates of the slowly-exchanging amide protons in sperm whale myoglobin have been mapped using 15N-1H NMR spectroscopy.	Hydrogen	124-126	myoglobin	Physeter catodon	87-96
34783528-6	2021	The superior catalytic performance of beta-Sb has been described by its electronic structures, charge transfer mechanism, and suitable valence and conduction band edge positions versus normal hydrogen electrode.	Hydrogen	192-200	5'-aminolevulinate synthase 2	Homo sapiens	38-45
34783528-8	2021	In general, the Bi@beta-Sb monolayer may be an excellent trifunctional catalyst that exhibits high activity toward all electrode reactions of hydrogen and oxygen.	Hydrogen	142-150	5'-aminolevulinate synthase 2	Homo sapiens	19-26
34797663-5	2021	By Fourier transform infrared spectroscopy (FTIR) and molecular docking simulations, it was observed that the hydroxyl group in UA formed hydrogen bonding with the carbonyl group in SA.	Hydrogen	138-146	acyl-CoA synthetase medium chain family member 3	Homo sapiens	182-184
34537295-4	2021	The product (CS-TSe) was characterized in detail by FTIR, NMR (1H, 13C, and 77Se) and UV-Vis techniques, and SEM microscopy.	Hydrogen	63-65	citrate synthase	Homo sapiens	13-15
16446384-9	2006	Two hCNT3 pharmacophore models revealed the minimal features required for hCNT3 transport as two hydrogen bond acceptors at 3"-OH and 5"-O and the hydrophobic center occupied by the base ring.	Hydrogen	97-105	solute carrier family 28 member 3	Homo sapiens	74-79
16610910-3	2006	There are marked differences in H(2) solubilities between ordered and disordered Pd-Mn alloys with the largest difference found between the L1(2) and the disordered form of the Pd(3)Mn alloy.	Hydrogen	32-36	LINE1 retrotransposable element 1	Homo sapiens	140-145
34726908-6	2021	Interestingly, the catalytic activity of the hydrogen evolution reaction (HER) for the Au-Ag/Ag2S heterojunction nanorods (HJNRs) are higher than that for the Ag-Au-Ag HJNRs, although they have a lower surface temperature during photocatalysis; therefore, hot carriers and electronic structure contributed more to the catalytic activity of the Au-Ag/Ag2S HJNRs than that of the Ag-Au-Ag HJNRs.	Hydrogen	45-53	angiotensin II receptor type 1	Homo sapiens	93-97
34726908-6	2021	Interestingly, the catalytic activity of the hydrogen evolution reaction (HER) for the Au-Ag/Ag2S heterojunction nanorods (HJNRs) are higher than that for the Ag-Au-Ag HJNRs, although they have a lower surface temperature during photocatalysis; therefore, hot carriers and electronic structure contributed more to the catalytic activity of the Au-Ag/Ag2S HJNRs than that of the Ag-Au-Ag HJNRs.	Hydrogen	45-53	angiotensin II receptor type 1	Homo sapiens	350-354
10561612-6	1999	The crystal structural analyses of K1M, K1A and Gly(-1) revealed that the introduction of a residue at the N-terminal of human lysozyme caused the destruction of hydrogen bond networks with ordered water molecules, resulting in the destabilization of the protein.	Hydrogen	162-170	threonine aldolase 1, pseudogene	Homo sapiens	35-54
16610910-6	2006	The enthalpies for absorption of H(2) are more exothermic over most of the range of H contents for the L1(2) forms of the Pd(3)Mn and Pd(0.80)Mn(0.20) alloys than for their other forms.	Hydrogen	33-37	LINE1 retrotransposable element 1	Homo sapiens	103-108
16562956-4	2006	The reaction of 1Cl or 1H with O2 at -78 degrees C in CH2Cl2 gives UV-vis and resonance Raman spectra indicative of a mu-eta2:eta2-(side-on)-peroxo dicopper(II) adduct (2R).	Hydrogen	23-25	DNA polymerase iota	Homo sapiens	121-125
10544278-7	1999	Higher protection against hydrogen exchange for residues in part of the beta4 strand implies that this region might serve as a folding core.	Hydrogen	26-34	tubulin beta 3 class III	Homo sapiens	72-77
34822896-5	2022	Results show that long-chain hydrocarbons in PS-1 are adsorbed on the non-polar region of UC by Van der Waals force, while -COOH groups in PS-1 are adsorbed on the polar sites of -COOH and -OH of UC by hydrogen bonds.	Hydrogen	202-210	presenilin 1	Homo sapiens	139-143
16562956-4	2006	The reaction of 1Cl or 1H with O2 at -78 degrees C in CH2Cl2 gives UV-vis and resonance Raman spectra indicative of a mu-eta2:eta2-(side-on)-peroxo dicopper(II) adduct (2R).	Hydrogen	23-25	DNA polymerase iota	Homo sapiens	126-130
16522801-8	2006	Together with two iron-binding residues (His49 and Glu55), Asp120, Asn51, Glu111, and Arg114 form a hydrogen-bonding network; this hydrogen-bond network is key to the catalysis of 3HAO.	Hydrogen	100-108	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	180-184
34121768-9	2021	SARS-CoV2 nsp1 protein binds with the interface region of the palm and finger domain of POLA1 via hydrogen bonding and salt bridge interactions.	Hydrogen	98-106	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	88-93
10563508-2	1999	Preliminary 1H NMR experiments performed on Vpr fragments showed the presence of several helical regions.	Hydrogen	12-14	Vpr	Human immunodeficiency virus 1	44-47
16522801-8	2006	Together with two iron-binding residues (His49 and Glu55), Asp120, Asn51, Glu111, and Arg114 form a hydrogen-bonding network; this hydrogen-bond network is key to the catalysis of 3HAO.	Hydrogen	131-139	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	180-184
16551082-0	2006	An interweaving MOF with high hydrogen uptake.	Hydrogen	30-38	lysine acetyltransferase 8	Homo sapiens	16-19
10508788-8	1999	P38gamma residue phosphoryl-Thr183 forms hydrogen bonds with five basic amino acids, and these interactions induce an interdomain rotation.	Hydrogen	41-49	mitogen-activated protein kinase 12	Homo sapiens	0-8
34689562-0	2021	Activating Carbon Nitride by BP@Ni for the Enhanced Photocatalytic Hydrogen Evolution and Selective Benzyl Alcohol Oxidation.	Hydrogen	67-75	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	29-31
16509583-7	2006	A related docking study of 13e in the 15-LOX binding site indicates that the C-3 p-SO2Me COX-2 pharmacophore was positioned in a region closer to the catalytic iron site where it undergoes a hydrogen bonding interaction with His541 and His366, and that the C-1 p-i-Pr substituent is buried deep in a hydrophobic pocket (Ile414, Ile418, Met419 and Ile593) near the base of the 15-LOX binding site.	Hydrogen	191-199	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	89-94
34608744-6	2021	Cardamonin achieved a significant inhibition of the apyrase activity and the three-dimensional structure of the potato apyrase, obtained by homology modeling, showed that cardamonin may interact mainly through hydrogen bonds.	Hydrogen	210-218	apyrase	Solanum tuberosum	119-126
10485712-6	1999	Fluorescence studies both with and without a "trap" version of the chaperonin GroEL, which binds non-native forms of GFP, and hydrogen-exchange experiments directly demonstrate that ClpA can unfold stable, native proteins in the presence of ATP.	Hydrogen	126-134	T-box transcription factor 22	Homo sapiens	182-186
16221734-8	2006	This latter observation is consistent with the unique expression of the T-type VSCC Cav3.2 (alpha(1H)) in terminally differentiated osteocytes as we recently reported.	Hydrogen	98-100	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	84-90
10447959-7	1999	Excellent inhibitory potency and selectivity for nNOS over eNOS and iNOS is achieved with the dipeptide amides containing a basic amine side chain (20-24), which indicates a possible electrostatic (or hydrogen bonding) interaction at the enzyme active site.	Hydrogen	201-209	nitric oxide synthase 1	Homo sapiens	49-53
10481277-0	1999	1H and 15N chemical shift assignments for domain 4 of the common beta-chain of the IL-3, IL-5 and GM-CSF receptors.	Hydrogen	0-2	interleukin 5	Homo sapiens	89-93
10481282-0	1999	1H, 15N and 13C resonance assignments for the bromodomain of the histone acetyltransferase P/CAF.	Hydrogen	0-2	lysine acetyltransferase 2B	Homo sapiens	65-96
34655613-5	2021	First, using a combination of circular dichroism, NMR, and hydrogen/deuterium exchange mass spectrometry (HDX-MS), we confirmed that the N-terminal half, which is the interacting part of Mint3, is mostly disordered.	Hydrogen	59-67	amyloid beta precursor protein binding family A member 3	Homo sapiens	187-192
16892371-1	2006	Recently developed hydrogen-bonding and hydrophobic analysis algorithms were used to investigate the interaction properties of the ATP binding sites of CDK2, CDK4, and ERK2.	Hydrogen	19-27	cyclin dependent kinase 2	Homo sapiens	152-156
34418874-7	2021	Hydrogen (H)-bond occupancy analysis reveals a similar DNA binding behavior for MEF2WT and MEF2BY69H, compared to MEF2BK4E structure.	Hydrogen	0-8	myocyte enhancer factor 2A	Homo sapiens	80-84
34690521-7	2022	Furin, a target protein of COVID-19, has a greater binding affinity (-12.04 kcal/mol) than other COVID-19 target proteins, forming different hydrogen bonds and polar and hydrophobic interactions, suggesting that it might be used as an antiviral treatment against SARS-CoV-2.	Hydrogen	141-149	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
34721070-9	2021	Unlike vitamin C, hydrogen inhalation did not blunt post-exercise mitochondrial biogenetic signals, but resulted in an increase in complex IV concentration, activation of PGC-1alpha, and TFAM and NRF-2 gene transcription, and up-regulation of PGC-1alpha protein expression.	Hydrogen	18-26	transcription factor A, mitochondrial	Rattus norvegicus	187-191
10329775-4	1999	The two end base pairs of duplex 1 have a similar NH.O hydrogen-bond pattern involving GGC segments of duplex 2 and a symmetry-related neighbour, while the end base pairs of duplex 2 interact with the GCC and GGG segments of its symmetry-related neighbours through NH.O and NH.N hydrogen bonds and a water-mediated hydrogen bond between the carboxyl groups of C40 and C8.	Hydrogen	55-63	guanylate cyclase 2C	Homo sapiens	201-204
10329775-4	1999	The two end base pairs of duplex 1 have a similar NH.O hydrogen-bond pattern involving GGC segments of duplex 2 and a symmetry-related neighbour, while the end base pairs of duplex 2 interact with the GCC and GGG segments of its symmetry-related neighbours through NH.O and NH.N hydrogen bonds and a water-mediated hydrogen bond between the carboxyl groups of C40 and C8.	Hydrogen	279-287	guanylate cyclase 2C	Homo sapiens	201-204
10329775-4	1999	The two end base pairs of duplex 1 have a similar NH.O hydrogen-bond pattern involving GGC segments of duplex 2 and a symmetry-related neighbour, while the end base pairs of duplex 2 interact with the GCC and GGG segments of its symmetry-related neighbours through NH.O and NH.N hydrogen bonds and a water-mediated hydrogen bond between the carboxyl groups of C40 and C8.	Hydrogen	279-287	guanylate cyclase 2C	Homo sapiens	201-204
16892371-1	2006	Recently developed hydrogen-bonding and hydrophobic analysis algorithms were used to investigate the interaction properties of the ATP binding sites of CDK2, CDK4, and ERK2.	Hydrogen	19-27	cyclin dependent kinase 4	Homo sapiens	158-162
16229893-4	2006	Our results reveal subtle differences in the structures of the beta2m variants, namely in minor loop shifts and in variations in the hydrogen bonding networks at the interfaces between the components of the ternary complex.	Hydrogen	133-141	beta-2 microglobulin	Mus musculus	63-69
10427749-0	1999	Assignment of 1H, 13C and 15N resonances of the a" domain of protein disulfide isomerase.	Hydrogen	14-16	prolyl 4-hydroxylase subunit beta	Homo sapiens	61-88
16477002-9	2006	The IL-2/gamma(c) interface itself exhibits the smallest buried surface and the fewest hydrogen bonds in the complex, which is consistent with its promiscuous use in other cytokine receptor complexes.	Hydrogen	87-95	interleukin 2 receptor subunit gamma	Homo sapiens	9-17
10404735-4	1999	Sodium/hydrogen exchanger activity was estimated from the recovery of pHi clamped to 6.25 with nigericin.	Hydrogen	7-15	glucose-6-phosphate isomerase	Homo sapiens	70-73
16375919-5	2006	Comparison of the interface between beta(2)m and the alpha(1)alpha(2) domains of the heavy chain in these two crystal structures reveals a marked increase in both polarity and number of hydrogen bonds between hbeta(2)m and the alpha(1)alpha(2) domains of H-2D(b).	Hydrogen	186-194	beta-2 microglobulin	Mus musculus	36-44
10382315-0	1999	Sequence-specific 1H, 13C and 15N assignment and secondary structure of the apo EH2 domain of mouse Eps15.	Hydrogen	18-20	epidermal growth factor receptor pathway substrate 15	Mus musculus	100-105
16448106-1	2006	Progressive isomorphous incorporation of TiIV (or BIII) heteroatoms into the MFI structure of as-synthesized silicalite-1 caused a decrease in the amount of siloxy groups (anions), requisite for counter-balancing the structural directing agent (cation), as determined using 1H MAS NMR to quantify the silanol protons H-bonded to the siloxy oxygen.	Hydrogen	274-276	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	50-54
10559866-3	1999	The crystal structure of CDK2 in complex with indirubin derivatives shows that indirubin interacts with the kinase"s ATP-binding site through van der Waals interactions and three hydrogen bonds.	Hydrogen	179-187	cyclin dependent kinase 2	Homo sapiens	25-29
17168729-4	2006	Two evidences playing important roles for the inhibition by the active compounds, are 1) C-1 and C-3" hydroxyl groups formed hydrogen bonds with COX-2/COX-1 Val523/Ile523 and Arg120, respectively, 2) hydrogen at C-5 of the naphthalene nucleus was attracted rather close to the phenolic group of Tyr385 due to van der Waals interaction.	Hydrogen	125-133	VPS52 subunit of GARP complex	Homo sapiens	82-87
17168729-4	2006	Two evidences playing important roles for the inhibition by the active compounds, are 1) C-1 and C-3" hydroxyl groups formed hydrogen bonds with COX-2/COX-1 Val523/Ile523 and Arg120, respectively, 2) hydrogen at C-5 of the naphthalene nucleus was attracted rather close to the phenolic group of Tyr385 due to van der Waals interaction.	Hydrogen	200-208	VPS52 subunit of GARP complex	Homo sapiens	82-87
10212197-4	1999	In arylsulfatase A and N-acetylgalactosamine 4-sulfatase this formylglycine was found to form the active site together with a divalent cation and a number of polar residues, tightly interconnected by a net of hydrogen bonds.	Hydrogen	209-217	arylsulfatase A	Homo sapiens	3-18
16633989-8	2006	Quantitative polymerase chain reaction (PCR) and Western blot analysis reveal that in diabetic rats compared with controls, mRNA and protein abundance was higher for type 3 sodium/hydrogen exchanger (NHE3) in proximal tubule and ascending limbs of Henle"s loop, and higher for bumetanide-sensitive sodium-potassium-2 chloride cotransporter (NKCC2) in ascending limbs of Henle"s loop.	Hydrogen	180-188	solute carrier family 9 member A3	Rattus norvegicus	200-204
10353201-0	1999	1H, 15N and 13C assignments of the DNA binding domain of transcription factor Mbp1 from S. cerevisiae in both its free and the DNA bound forms, and 1H assignments of the free DNA.	Hydrogen	0-2	transcription factor MBP1	Saccharomyces cerevisiae S288C	78-82
16404162-0	2005	Backbone 1H, 15N, and 13C resonance assignments and secondary-structure of conserved hypothetical protein HP0894 from Helicobacter pylori.	Hydrogen	9-11	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Helicobacter pylori 26695	106-112
10082521-8	1999	A sixth maternal HS site, at 3.45 kb upstream of H19, was detected in ES cells only.	Hydrogen	17-19	H19, imprinted maternally expressed transcript	Mus musculus	49-52
16366575-5	2005	These observations are consistent with 1H NMR data for the neutral DAC-NO complex that indicate the presence of two geometric isomers in solution.	Hydrogen	39-41	arylacetamide deacetylase	Homo sapiens	67-70
10024026-6	1999	Specifically, in the CYP4A11-lauric acid simulations, the omega hydrogens were closest to the ferryl oxygen most of the time.	Hydrogen	64-73	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	21-28
16305190-1	2005	The pentamethylcyclopentadienyl iron cation, generated from [(eta5-C5Me5)Fe(NCMe)3]PF6, triggers the room temperature cycloaromatization of acyclic and alicyclic enediynes, in the presence of either 1,4-cyclohexadiene or terpinene as the hydrogen-atom donor, to give metal-arene products in good to excellent yields.	Hydrogen	238-246	sperm associated antigen 17	Homo sapiens	83-86
9931261-5	1999	The backbone 1H, 13C, and 15N magnetic resonances of the Raf-1 RBD were assigned in complexes with the wild-type and D30E/E31K mutant Ras proteins in the guanosine 5"-O-(beta,gamma-imidotriphosphate)-bound form.	Hydrogen	13-15	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	57-62
10092845-9	1999	Preliminary 1H-NMR spectroscopic data for r-NTP and r-PRG B indicate relatively fast amide 1H-2H exchange in 2H2O and close conformational characteristics for the two homologous polypeptides.	Hydrogen	12-14	plasminogen like B1	Homo sapiens	54-59
10092845-9	1999	Preliminary 1H-NMR spectroscopic data for r-NTP and r-PRG B indicate relatively fast amide 1H-2H exchange in 2H2O and close conformational characteristics for the two homologous polypeptides.	Hydrogen	91-93	plasminogen like B1	Homo sapiens	54-59
10025828-5	1999	MAO metabolism of PHEN was inhibited at the tracer level by substituting deuterium atoms for the two hydrogen atoms at the alpha-carbon side chain position to yield the MAO-resistant analog D2-PHEN.	Hydrogen	101-109	monoamine oxidase A	Rattus norvegicus	0-3
9874700-1	1999	The interaction of cyclosporin A (CsA) with dimethyl-alpha- and -beta-cyclodextrins (DM-alpha-CyD and DM-beta-CyD) was investigated by the solubility method, electrospray ionization mass spectrometry (ESI-MS) and 1H-nuclear magnetic resonance spectroscopy (1H NMR).	Hydrogen	213-215	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	34-37
9874700-1	1999	The interaction of cyclosporin A (CsA) with dimethyl-alpha- and -beta-cyclodextrins (DM-alpha-CyD and DM-beta-CyD) was investigated by the solubility method, electrospray ionization mass spectrometry (ESI-MS) and 1H-nuclear magnetic resonance spectroscopy (1H NMR).	Hydrogen	257-259	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	34-37
9874700-6	1999	CsA gave many new peaks in the 1H NMR spectrum when the solvent was changed from chloroform to methanol/water, suggesting conformational diversity of CsA in polar solvents.	Hydrogen	31-33	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	0-3
9874700-6	1999	CsA gave many new peaks in the 1H NMR spectrum when the solvent was changed from chloroform to methanol/water, suggesting conformational diversity of CsA in polar solvents.	Hydrogen	31-33	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	150-153
9874700-7	1999	Inspection of 1H-chemical shift changes and the two-dimensional rotating frame nuclear Overhauser effect (ROESY) spectra of the CsA/DM-CyD system suggested that the side chains of amino acids in CsA molecule take part in the inclusion within DM-CyDs, although there is seemingly no preference of particular amino acid residues.	Hydrogen	14-16	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	195-198
29711302-2	1998	Weak C-H   S and C-H   Se hydrogen-bonding interactions in addition to C-H   N hydrogen bonds are responsible for the observed structures.	Hydrogen	26-34	lysosomal trafficking regulator	Homo sapiens	5-20
29711302-2	1998	Weak C-H   S and C-H   Se hydrogen-bonding interactions in addition to C-H   N hydrogen bonds are responsible for the observed structures.	Hydrogen	79-87	lysosomal trafficking regulator	Homo sapiens	5-20
9790687-6	1998	These experiments demonstrated the transfer of five protons from buffer to BNP on heparin binding, suggesting that hydrogen bonding between the polar residues of BNP and heparin is a major factor contributing to the free energy of BNP binding to heparin.	Hydrogen	115-123	natriuretic peptide B	Homo sapiens	75-78
9790687-6	1998	These experiments demonstrated the transfer of five protons from buffer to BNP on heparin binding, suggesting that hydrogen bonding between the polar residues of BNP and heparin is a major factor contributing to the free energy of BNP binding to heparin.	Hydrogen	115-123	natriuretic peptide B	Homo sapiens	162-165
9790687-6	1998	These experiments demonstrated the transfer of five protons from buffer to BNP on heparin binding, suggesting that hydrogen bonding between the polar residues of BNP and heparin is a major factor contributing to the free energy of BNP binding to heparin.	Hydrogen	115-123	natriuretic peptide B	Homo sapiens	162-165
9746775-5	1998	These findings provide evidence that immune thrombocytopenia can be caused by sensitivity to an H2 R antagonist and suggest that the SZ1 binding site on GPIX may be a common target for drug-induced antibodies.	Hydrogen	96-98	DLG2 antisense RNA 1	Homo sapiens	133-136
9746775-5	1998	These findings provide evidence that immune thrombocytopenia can be caused by sensitivity to an H2 R antagonist and suggest that the SZ1 binding site on GPIX may be a common target for drug-induced antibodies.	Hydrogen	96-98	glycoprotein IX platelet	Homo sapiens	153-157
9835057-0	1998	Sequence-specific 1H, 13C and 15N assignment of the EH1 domain of mouse Eps15.	Hydrogen	18-20	epidermal growth factor receptor pathway substrate 15	Mus musculus	72-77
9761475-6	1998	Interactions of CB-NTP with each of the Pgn kringles were monitored by 1H-NMR at 500 MHz and values for the equilibrium association constants (Ka) determined: rK1, Ka approximately 4.6 mM(-1); rK2, Ka approximately 3.3 mM(-1); K4, Ka approximately 6.2 mM-"; K5, K, 2.3 mM(-1).	Hydrogen	71-73	plasminogen	Homo sapiens	40-43
9761476-1	1998	Interactions between the kringle 4 (K4) domain of human plasminogen (Pgn) and segments of the N-terminal Glu1-Lys77 peptide (NTP) have been investigated via 1H-NMR at 500 MHz.	Hydrogen	157-159	plasminogen	Homo sapiens	56-67
9761476-1	1998	Interactions between the kringle 4 (K4) domain of human plasminogen (Pgn) and segments of the N-terminal Glu1-Lys77 peptide (NTP) have been investigated via 1H-NMR at 500 MHz.	Hydrogen	157-159	plasminogen	Homo sapiens	69-72
9609701-9	1998	Removal of a very small number of hydrogen bonds substantially increases the unfolding rate, a phenomenon which may be important in stress-relaxation of FNIII-containing muscle proteins such as titin.	Hydrogen	34-42	titin	Homo sapiens	194-199
9597181-3	1998	1H NMR measurements in aqueous solution together with molecular modeling studies indicated that there were conformational differences of the C-2 and C-6 side chains in this series of compounds.	Hydrogen	0-2	complement C6	Homo sapiens	149-152
10374632-3	1998	rCBF was monitored in striatum using hydrogen clearance method.	Hydrogen	37-45	CCAAT/enhancer binding protein zeta	Rattus norvegicus	0-4
9490409-3	1998	The otherwise flexible amino-terminal extension of the MATalpha2 homeodomain forms a beta-hairpin that grips the MCM1 surface through parallel beta-strand hydrogen bonds and close-packed, predominantly hydrophobic, side chains.	Hydrogen	155-163	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	55-64
9451007-4	1998	We determined the solution structure of human CENP-B DBD RP1 by multi-dimensional 1H, 13C and 15N NMR methods.	Hydrogen	82-84	RP1 axonemal microtubule associated	Homo sapiens	57-60
9489531-4	1998	METHODS: A 1H MRS study was performed on five patients with relapsing-remitting multiple sclerosis who were being treated with intramuscular IFN beta-1a (6 million units/week) for six months and on five untreated patients.	Hydrogen	11-13	interferon beta 1	Homo sapiens	141-149
9428659-0	1997	A 1H NMR comparative study of the structure of the critical packing interfaces between helix and non-helical region in various ligation states of sperm whale myoglobin.	Hydrogen	2-4	myoglobin	Physeter catodon	158-167
9367861-0	1997	The generation of 1H-NMR-detectable mobile lipid in stimulated lymphocytes: relationship to cellular activation, the cell cycle, and phosphatidylcholine-specific phospholipase C. Mobile lipids detected using 1H-NMR in stimulated lymphocytes were correlated with cell cycle phase, expression of the interleukin-2 receptor alpha and proliferation to assess the activation status of the lymphocytes.	Hydrogen	18-20	interleukin 2 receptor subunit alpha	Homo sapiens	298-326
9367861-0	1997	The generation of 1H-NMR-detectable mobile lipid in stimulated lymphocytes: relationship to cellular activation, the cell cycle, and phosphatidylcholine-specific phospholipase C. Mobile lipids detected using 1H-NMR in stimulated lymphocytes were correlated with cell cycle phase, expression of the interleukin-2 receptor alpha and proliferation to assess the activation status of the lymphocytes.	Hydrogen	208-210	interleukin 2 receptor subunit alpha	Homo sapiens	298-326
9583116-6	1997	Stimulating effect of acetone and ethanol on actomyosine ATPase is probably determined by superposition of two components: that connected with direct effect of these solvents on the protein catalyst (interaction with enzyme with the future break of hydrogen and hydrophobic bonds in the protein and its "fluffing") and "electrostatic component" determined by the change of D value of the incubation medium.	Hydrogen	249-257	dynein axonemal heavy chain 8	Homo sapiens	57-63
9148770-7	1997	Three-dimensional modelling of the Csk kinase domain indicated that the Y304F mutation abolishes one of two conserved hydrogen bonds between the upper and the lower lobes in the open conformation of the kinase domain.	Hydrogen	118-126	C-terminal Src kinase	Homo sapiens	35-38
9033390-1	1997	The heme propionate groups of both myoglobin (Mb) and cytochrome b5 form hydrogen bonds with nearby surface amino acids residues that are believed to stabilize the heme-protein complex.	Hydrogen	73-81	cytochrome b5 type A	Equus caballus	54-67
9033390-2	1997	To evaluate the magnitude of this stabilization, the kinetics of heme dissociation from variants of horse heart Mb and cytochrome b5 in which these hydrogen bonding interactions have been systematically eliminated were studied by the method of Hargrove and colleagues (1994), and their thermal stability was assessed.	Hydrogen	148-156	cytochrome b5 type A	Equus caballus	119-132
8995257-8	1997	Monitoring the amide hydrogen/deuterium exchange kinetics demonstrated that the membrane associated part of the ATPase molecule is characterized by a relatively high accessibility to the solvent, quite different from that observed for bacteriorhodopsin membrane segments.	Hydrogen	21-29	dynein axonemal heavy chain 8	Homo sapiens	112-118
8942668-1	1996	His 238, a conserved amino acid located in hydrogen-bonding distance from C-6 of the substrate in the active site of murine adenosine deaminase (mADA) and postulated to play an important role in catalysis, was altered into an alanine, a glutamate, and an arginine using site-directed mutagenesis.	Hydrogen	43-51	adenosine deaminase	Mus musculus	124-143
8942668-1	1996	His 238, a conserved amino acid located in hydrogen-bonding distance from C-6 of the substrate in the active site of murine adenosine deaminase (mADA) and postulated to play an important role in catalysis, was altered into an alanine, a glutamate, and an arginine using site-directed mutagenesis.	Hydrogen	43-51	adenosine deaminase	Mus musculus	145-149
15299564-17	1996	For the first time hydrogen bonds were observed between the main-chain peptide N and O atoms of the complementarity-determining region CDR2 and CDR3 segments of both monomers.	Hydrogen	19-27	cerebellar degeneration related protein 2	Homo sapiens	135-139
15299564-17	1996	For the first time hydrogen bonds were observed between the main-chain peptide N and O atoms of the complementarity-determining region CDR2 and CDR3 segments of both monomers.	Hydrogen	19-27	CDR3	Homo sapiens	144-148
8901555-0	1996	beta-Lactamase binds to GroEL in a conformation highly protected against hydrogen/deuterium exchange.	Hydrogen	73-81	beta-lactamase	Escherichia coli	0-14
8897610-5	1996	1H-15N heteronuclear T1, T2, and steady-state NOE measurements indicate that the backbone of MIF exists in a rigid structure of limited conformational flexibility (on the nanosecond to picosecond time scale).	Hydrogen	0-2	macrophage migration inhibitory factor	Homo sapiens	93-96
8831765-5	1996	A number of electrostatic and hydrogen-bonding interactions can be detected between mGluR1 agonists such as L-Glu (1), Quis (2), and (1S,3R)-ACPD (4) and binding site residues.	Hydrogen	30-38	glutamate metabotropic receptor 1	Homo sapiens	84-90
8841379-0	1996	Hydrogen-exchange kinetics in the cold denatured state of ribonuclease A.	Hydrogen	0-8	ribonuclease A family member 1, pancreatic	Homo sapiens	58-72
8841379-2	1996	Our main interest in this study was to investigate the pressure-assisted cold denatured state of RNase A by hydrogen exchange techniques.	Hydrogen	108-116	ribonuclease A family member 1, pancreatic	Homo sapiens	97-104
8841379-4	1996	A qualitative analysis of the hydrogen-exchange rates suggests that cold denatured RNase A behaves markedly differently from a random coil, probably due to patches of residual secondary structure.	Hydrogen	30-38	ribonuclease A family member 1, pancreatic	Homo sapiens	83-90
34508625-11	2021	Molecular docking analysis shows that ABL1 interacts with Cofilin1 mainly through hydrogen bonds and ionic interaction between amino acid residues.	Hydrogen	82-90	cofilin 1	Homo sapiens	58-66
34633106-11	2022	A docking model shows that NP1 interacted primarily with TK-EGFR via hydrogen bonding.	Hydrogen	69-77	neuropilin 1	Homo sapiens	27-30
34173222-0	2021	1H, 13C, 15N backbone resonance assignment for the 1-164 construct of human XRCC4.	Hydrogen	0-2	X-ray repair cross complementing 4	Homo sapiens	76-81
34173222-10	2021	In this work we report the 1H, 15 N and 13C backbone resonance assignments of human XRCC4 in the solution form of the 1-164 construct.	Hydrogen	27-29	X-ray repair cross complementing 4	Homo sapiens	84-89
34621897-7	2021	The main protein-protein interaction mechanism between AGPS and HNRNPK is hydrogen bond, conjugation bond, hydrophobic bond, and electrostatic force by computer simulation prediction.	Hydrogen	74-82	alkylglycerone phosphate synthase	Homo sapiens	55-59
34621897-7	2021	The main protein-protein interaction mechanism between AGPS and HNRNPK is hydrogen bond, conjugation bond, hydrophobic bond, and electrostatic force by computer simulation prediction.	Hydrogen	74-82	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	64-70
34524348-4	2021	1H NMR monitoring showed that these compounds are very resistant to UV (lambda = 365 nm) or sunlight irradiation and do not undergo photodegradation with a loss of antiproliferative activity that is inherent in heterocyclic analogues of CA-4.	Hydrogen	0-2	carbonic anhydrase 4	Homo sapiens	237-241
34612418-1	2021	Ab initio calculations have been performed to investigate the competition and conversion between the pnicogen bonds and hydrogen bonds in complexes containing prototype organophosphorus compounds RPO2 (R = CH3 and CH3O).	Hydrogen	120-128	RNA polymerase II subunit A	Homo sapiens	196-200
34492763-3	2021	Herein, solution 1H nuclear magnetic resonance methods were used to monitor ligand exchange reactions on stoichiometric Ag2S nanocrystal platforms with various primary amine and carboxylic acid ligands.	Hydrogen	17-19	angiotensin II receptor type 1	Homo sapiens	120-124
34229394-3	2021	The SnS2 electrode also demonstrates an excellent catalytic activity towards hydrogen evolution reaction in a wide pH range (0-14).	Hydrogen	77-85	sodium voltage-gated channel alpha subunit 11	Homo sapiens	4-8
34134437-0	2021	A direct dual Z-scheme 3DOM SnS2-ZnS/ZrO2 composite with excellent photocatalytic degradation and hydrogen production performance.	Hydrogen	98-106	sodium voltage-gated channel alpha subunit 11	Homo sapiens	28-32
34350692-3	2022	Structural analyses of 1-Pro-His suggested that the peptide backbone of (SeH,SeH) is rigidly bent to form a gamma-turn, possibly including an NH   Se hydrogen bond between the imidazole ring of His and selenol group, thus stabilizing the (SeH,SeH) form thermodynamically, and dramatically enhancing the catalytic activity.	Hydrogen	150-158	epoxide hydrolase 2	Homo sapiens	73-76
34350692-3	2022	Structural analyses of 1-Pro-His suggested that the peptide backbone of (SeH,SeH) is rigidly bent to form a gamma-turn, possibly including an NH   Se hydrogen bond between the imidazole ring of His and selenol group, thus stabilizing the (SeH,SeH) form thermodynamically, and dramatically enhancing the catalytic activity.	Hydrogen	150-158	epoxide hydrolase 2	Homo sapiens	77-80
34350692-3	2022	Structural analyses of 1-Pro-His suggested that the peptide backbone of (SeH,SeH) is rigidly bent to form a gamma-turn, possibly including an NH   Se hydrogen bond between the imidazole ring of His and selenol group, thus stabilizing the (SeH,SeH) form thermodynamically, and dramatically enhancing the catalytic activity.	Hydrogen	150-158	epoxide hydrolase 2	Homo sapiens	239-242
34350692-3	2022	Structural analyses of 1-Pro-His suggested that the peptide backbone of (SeH,SeH) is rigidly bent to form a gamma-turn, possibly including an NH   Se hydrogen bond between the imidazole ring of His and selenol group, thus stabilizing the (SeH,SeH) form thermodynamically, and dramatically enhancing the catalytic activity.	Hydrogen	150-158	epoxide hydrolase 2	Homo sapiens	243-246
34216889-5	2021	The antiviral drug Sofosbuvir reduced the number of hydrogen bonds formed between RdRp and RNA.	Hydrogen	52-60	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	82-86
34216889-6	2021	Remdesivir bound more tightly to viral RNA than viral RdRp alone or the nsp12-7-8 hexadecameric complex, resulting in a significant number of hydrogen bonds being formed in the uracil-rich region.	Hydrogen	142-150	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	54-58
34153880-4	2021	In this study, we demonstrate the CSA recoupling of strongly dipolar coupled 1H spins using the Cnn1(9003601805400360180900) sequence.	Hydrogen	77-79	calponin 1	Homo sapiens	96-100
34270204-4	2021	The dynamically cross-linked chitosan (CS) and the flexible polyacrylamide network doped with polyaniline constitute the DN through the hydrogen bonds between the hydroxyl, amide, and aniline groups.	Hydrogen	136-144	citrate synthase	Homo sapiens	39-41
34340378-3	2021	While it has previously been shown that subsurface hydrogen stabilizes CO2 and can aid in overcoming reaction barriers, the role of bulk hydrogen is less studied and thus unknown with regard to CO2 reduction.	Hydrogen	51-59	activation induced cytidine deaminase	Homo sapiens	83-86
34513548-6	2021	In the structure of monomeric CcO, a hydrogen bond network of water molecules is formed at the entrance of the proton transfer K-pathway, and in dimeric CcO, this network is altered by a cholate molecule binding between monomers.	Hydrogen	37-45	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	30-33
34110159-4	2021	We find that the hydrogen bond networks are rearranged in the variants and also that new hydrogen bonds are established between the RBD and ACE2 as a result of mutations.	Hydrogen	17-25	angiotensin converting enzyme 2	Homo sapiens	140-144
34110159-4	2021	We find that the hydrogen bond networks are rearranged in the variants and also that new hydrogen bonds are established between the RBD and ACE2 as a result of mutations.	Hydrogen	89-97	angiotensin converting enzyme 2	Homo sapiens	140-144
34121407-7	2021	Here, the solution-based structural proteomic techniques, hydrogen-deuterium exchange mass spectrometry (HDX-MS) and cross-linking mass spectrometry (XL-MS), illuminate the dynamics of SARS-CoV-2 full-length nsp7 and nsp8 proteins and the nsp7:nsp8 protein complex.	Hydrogen	58-66	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	208-212
34121407-7	2021	Here, the solution-based structural proteomic techniques, hydrogen-deuterium exchange mass spectrometry (HDX-MS) and cross-linking mass spectrometry (XL-MS), illuminate the dynamics of SARS-CoV-2 full-length nsp7 and nsp8 proteins and the nsp7:nsp8 protein complex.	Hydrogen	58-66	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	239-243
34121407-7	2021	Here, the solution-based structural proteomic techniques, hydrogen-deuterium exchange mass spectrometry (HDX-MS) and cross-linking mass spectrometry (XL-MS), illuminate the dynamics of SARS-CoV-2 full-length nsp7 and nsp8 proteins and the nsp7:nsp8 protein complex.	Hydrogen	58-66	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	244-248
34234119-3	2021	We solved the crystal structure of RBD in complex with dACE2 and found that the total number of contact residues, contact atoms, hydrogen bonds and salt bridges at the binding interface in this complex are slightly fewer than those in the complex of the RBD and human ACE2 (hACE2).	Hydrogen	129-137	Acetylcholine esterase	Drosophila melanogaster	55-60
34230570-10	2021	The binding energies of 3 and 4 (- 8.5 and - 9.2 kcal/mol, respectively) for AChE were greater than that of 5 (- 8.3 kcal/mol), and 3 and 4 formed a hydrogen bond with Tyr124 in AChE.	Hydrogen	149-157	acetylcholinesterase	Canis lupus familiaris	77-81
34230570-10	2021	The binding energies of 3 and 4 (- 8.5 and - 9.2 kcal/mol, respectively) for AChE were greater than that of 5 (- 8.3 kcal/mol), and 3 and 4 formed a hydrogen bond with Tyr124 in AChE.	Hydrogen	149-157	acetylcholinesterase	Canis lupus familiaris	178-182
34111351-12	2021	The latter reactivity was observed upon reaction with internal alkynes and led to the corresponding eta2-alkyne derivatives via vinyl intermediates, which rearrange via a remarkable, hitherto unprecedented, hydrogen shift reaction.	Hydrogen	207-215	DNA polymerase iota	Homo sapiens	100-104
34133162-0	2021	Interactive Interface for Graph-Based Analyses of Dynamic H-Bond Networks: Application to Spike Protein S. Dynamic hydrogen-bond networks are key determinants of protein conformational dynamics.	Hydrogen	115-123	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	90-95
34133162-6	2021	The receptor binding domain of the spike protein hosts only a handful of persistent hydrogen-bond clusters, suggesting structural plasticity.	Hydrogen	84-92	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	35-40
34130570-6	2021	Residue-based free energy decomposition method was further utilized to decode the contributions of a single residue to binding of inhibitors, and it was found that three inhibitors not only produce hydrogen bonding interactions and hydrophobic interactions with key residues of CDK2, which promotes binding of three inhibitors to CDK2, but also share similar binding modes.	Hydrogen	198-206	cyclin dependent kinase 2	Homo sapiens	278-282
34130570-6	2021	Residue-based free energy decomposition method was further utilized to decode the contributions of a single residue to binding of inhibitors, and it was found that three inhibitors not only produce hydrogen bonding interactions and hydrophobic interactions with key residues of CDK2, which promotes binding of three inhibitors to CDK2, but also share similar binding modes.	Hydrogen	198-206	cyclin dependent kinase 2	Homo sapiens	330-334
34101577-3	2021	Our results showed that NompC could be opened by compression of the intracellular ankyrin repeat domain but not by a stretch, and a number of hydrogen bonds along the force convey pathway are important for the mechanosensitivity.	Hydrogen	142-150	no mechanoreceptor potential C	Drosophila melanogaster	24-29
34194664-8	2021	These distinctly different mechanisms were observed to be highly correlated to the protein secondary and tertiary structures of spA and spG ligands, as explicated from the perspective of hydrogen bonding.	Hydrogen	187-195	surfactant protein A1	Homo sapiens	128-131
34268097-2	2021	Researchers have already established the importance of measuring basal body temperature (BBT) and the potential of hydrogen (pH).	Hydrogen	115-123	phenylalanine hydroxylase	Homo sapiens	125-127
34812124-0	2021	Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX.	Hydrogen	0-8	carbonic anhydrase 9	Homo sapiens	129-134
34453711-0	2021	Profiling Structural Alterations During Rab5 Nucleotide Exchange by HDX-MS. Hydrogen deuterium exchange mass spectrometry (HDX-MS) gives insight into the structure of proteins.	Hydrogen	76-84	highly divergent homeobox	Homo sapiens	123-126
35085566-6	2022	Especially, CQDs/CIS-3 heterostructure presented the highest photocatalytic efficiency and its hydrogen generation activity (956.79 mumol g-1 h-1) was 7.57-fold improvement by contrast with pure CdIn2S4 (126.35 mumol g-1 h-1).	Hydrogen	95-103	suppressor of cytokine signaling 3	Homo sapiens	17-22
35149101-5	2022	XRD patterns and FT-IR spectra verified that the amino groups in CS formed hydrogen bonding with the hydroxyl groups in PUE.	Hydrogen	75-83	citrate synthase	Homo sapiens	65-67
35467350-8	2022	Ligand 2 is diving into the GRPR transmembrane (TM) helical cavity, thereby forming hydrogen bonds through its amidated end, water-mediated hydrogen bonds, and pi-pi interactions.	Hydrogen	84-92	gastrin releasing peptide receptor	Mus musculus	28-32
35467350-8	2022	Ligand 2 is diving into the GRPR transmembrane (TM) helical cavity, thereby forming hydrogen bonds through its amidated end, water-mediated hydrogen bonds, and pi-pi interactions.	Hydrogen	140-148	gastrin releasing peptide receptor	Mus musculus	28-32
35446879-8	2022	Moreover, all-atom molecular dynamics simulations concluded that the RBD of the Omicron variant exhibits a more dispersed interaction network since mutations resulted in an increased number of hydrophobic interactions and hydrogen bonds with hACE2.	Hydrogen	222-230	angiotensin converting enzyme 2	Homo sapiens	242-247
35394747-4	2022	Among them, the heterostructure with the largest EBI of 1.57 V attains the smallest overpotential of 97 mV at 10 mA cm-2 for the hydrogen evolution reaction and 243 mV at 50 mA cm-2 for the oxygen evolution reaction in 1 M KOH.	Hydrogen	129-137	transducin beta like 1 X-linked	Homo sapiens	49-52
35480391-5	2022	H1 binds to a polar groove at the S1 binding site by forming several hydrogen bonds with PLpro.	Hydrogen	69-77	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	89-94
35212057-6	2022	The H* produced by PdNPs migrate to the Pd1 sites to promote multiple proton-electron coupling transfer via hydrogen spillover.	Hydrogen	108-116	programmed cell death 1	Homo sapiens	40-43
35219911-7	2022	Remarkably, hydrogen (H) bond charge-relays distinguished these structures from the others; suggesting that CDR3 binding chemistry dictates CDR2 contacts on the opposite MHC-II alpha helix.	Hydrogen	12-20	CDR3	Homo sapiens	108-112
35219911-7	2022	Remarkably, hydrogen (H) bond charge-relays distinguished these structures from the others; suggesting that CDR3 binding chemistry dictates CDR2 contacts on the opposite MHC-II alpha helix.	Hydrogen	12-20	cerebellar degeneration related protein 2	Homo sapiens	140-144
8952349-1	1996	Localized proton magnetic resonance spectroscopy (1H-MRS) was conducted in two patients with herpes simplex virus type I encephalitis (HSE).	Hydrogen	50-52	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	135-138
8952349-9	1996	This is the first report assessing 1H-MRS for patients with HSE in Japan.	Hydrogen	35-37	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	60-63
8660368-5	1996	This refers to a monomeric Bet v 1 molecule in solution, which is also reflected in the narrow band width of the 1H-NMR spectrum.	Hydrogen	113-115	delta/notch like EGF repeat containing	Homo sapiens	27-30
16853774-1	2005	We study the isothermal hydrogen adsorption and reaction at the E-TEK electrode of a polymer electrolyte fuel cell with a Nafion 117 membrane by impedance spectroscopy at 30 degrees C. We find that the impedance diagram must include a Gerischer phase element.	Hydrogen	24-32	TEK receptor tyrosine kinase	Homo sapiens	66-69
16268581-4	2005	Addition of acid removes the ethoxy substituent and converts [(H,EtO)OCPH]H2 into the dication of "true" O-confused oxaporphyrin {[(H)OCPH]H3}2+ via an exocyclic C(3)-O bond cleavage followed by an elimination of the ethoxy group as determined by 1H NMR.	Hydrogen	247-249	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	65-68
8785331-8	1996	Upon exposure to 2H2O (D2O), 30% of the peptide amide groups in hPLB undergo a slow deuterium/hydrogen exchange.	Hydrogen	94-102	phospholamban	Homo sapiens	64-68
16358018-0	2005	Mechanism of HCS + O2 reaction: hydrogen- or oxygen-transfer?	Hydrogen	32-40	holocarboxylase synthetase	Homo sapiens	13-16
8615751-7	1996	c-N-I and c-N-II varied with respect to the following interactions with substrate: (1) hydrogen-bond formation with the substituent in the 6-position of the purine ring (a donor-type with c-N-I and an acceptor-type with c-N-II); and (2) hydrophobic attraction of the 6-position unsubstituted purine ring (more pronounced with c-N-I than with c-N-II).	Hydrogen	87-95	5'-nucleotidase, cytosolic IA	Homo sapiens	0-5
8615751-7	1996	c-N-I and c-N-II varied with respect to the following interactions with substrate: (1) hydrogen-bond formation with the substituent in the 6-position of the purine ring (a donor-type with c-N-I and an acceptor-type with c-N-II); and (2) hydrophobic attraction of the 6-position unsubstituted purine ring (more pronounced with c-N-I than with c-N-II).	Hydrogen	87-95	5'-nucleotidase, cytosolic IA	Homo sapiens	10-15
8615751-7	1996	c-N-I and c-N-II varied with respect to the following interactions with substrate: (1) hydrogen-bond formation with the substituent in the 6-position of the purine ring (a donor-type with c-N-I and an acceptor-type with c-N-II); and (2) hydrophobic attraction of the 6-position unsubstituted purine ring (more pronounced with c-N-I than with c-N-II).	Hydrogen	87-95	5'-nucleotidase, cytosolic IA	Homo sapiens	10-15
8632435-9	1996	The structure is stabilized by several hydrogen bonds and by a salt bridge between the guanidine moiety of Arg1 and the carboxyl group of Arg9, whereas the middle part of the peptide is buried in the micelle.	Hydrogen	39-47	arginase 1	Homo sapiens	107-111
16176874-10	2005	In addition, three-dimensional computerized modeling of the heme-binding site of the P450c17 enzyme indicated that replacement of Arg by Cys at amino acid position 440 predicts a loss of the catalytic activity of the enzyme, as the mutant enzyme containing Cys440 fails to form a hydrogen bond with the propionate group of heme, which renders the mutant enzyme unable to stabilize the proper position of heme.	Hydrogen	280-288	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	85-92
16853504-1	2005	1H NMR spectra corresponding to H2 adsorption on high-surface Rh/CeO2 catalysts (S(BET) approximately 55 m2/g) are formed by two lines, attributed to hydrogen adsorbed on ceria (resonance line A) and rhodium-metal particles (upfield-shifted line B).	Hydrogen	0-2	delta/notch like EGF repeat containing	Homo sapiens	83-86
16853504-1	2005	1H NMR spectra corresponding to H2 adsorption on high-surface Rh/CeO2 catalysts (S(BET) approximately 55 m2/g) are formed by two lines, attributed to hydrogen adsorbed on ceria (resonance line A) and rhodium-metal particles (upfield-shifted line B).	Hydrogen	32-34	delta/notch like EGF repeat containing	Homo sapiens	83-86
16853504-1	2005	1H NMR spectra corresponding to H2 adsorption on high-surface Rh/CeO2 catalysts (S(BET) approximately 55 m2/g) are formed by two lines, attributed to hydrogen adsorbed on ceria (resonance line A) and rhodium-metal particles (upfield-shifted line B).	Hydrogen	150-158	delta/notch like EGF repeat containing	Homo sapiens	83-86
16158459-3	2005	Pulse radiolysis experiments allowed limitation of the reduction potential of phenylurea.+ within 2.22 V versus the normal hydrogen electrode (NHE) &lt; E degrees (phenylurea.+/phenylurea) &lt; 2.43 V versus NHE.	Hydrogen	123-131	solute carrier family 9 member C1	Homo sapiens	143-146
16190753-7	2005	Direct hydrogen bonding of the cyano nitrogen of the 5-cyanopyrimidine core to the backbone NH of Met109 was confirmed by X-ray crystallographic analysis of 3a bound to p38alpha.	Hydrogen	7-15	mitogen-activated protein kinase 14	Mus musculus	169-177
15967794-0	2005	A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor.	Hydrogen	18-26	nuclear receptor subfamily 3 group C member 2	Homo sapiens	75-101
35368949-10	2022	Results: In this family comprising 10 HS patients, one novel mutation of the NCSTN gene was identified, involving a deletion mutation (c.447delC(p.N150Ifs*52)) in the NCSTN gene resulting in a frameshift and the new formation of a hydrogen bond.	Hydrogen	231-239	nicastrin	Homo sapiens	77-82
35368949-10	2022	Results: In this family comprising 10 HS patients, one novel mutation of the NCSTN gene was identified, involving a deletion mutation (c.447delC(p.N150Ifs*52)) in the NCSTN gene resulting in a frameshift and the new formation of a hydrogen bond.	Hydrogen	231-239	nicastrin	Homo sapiens	167-172
35227386-2	2022	In the presence of Cr3+ ion, its dependent DNAzyme can specifically cleave the substrate strand, resulting in the release of ligation probe, which will trigger hyperbranched rolling circle amplification (HRCA) to produce hydrogen ions, causing the color change of the solution containing cresol red.	Hydrogen	221-229	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	19-22
26641900-4	2005	This method provides results for H2/PAH interactions in close agreement with MP2 and higher-level ab initio methods.	Hydrogen	33-35	phenylalanine hydroxylase	Homo sapiens	36-39
35091154-8	2022	The interaction plots revealed the importance of fluorophenyl and the hydroxyl groups on piperidine that contribute toward the formation of hydrogen bonds with autotaxin.	Hydrogen	140-148	ectonucleotide pyrophosphatase/phosphodiesterase 2	Rattus norvegicus	160-169
15941664-3	2005	The CH2 selection in the SIJ (C H H) spin system is based on the three-spin coherence S(x)I(z)J(z), which is distinguished from 13C magnetization (S(x)) by a 1H 0 degrees/90 degrees pulse consisting of two 45 degrees pulses.	Hydrogen	158-160	RNA component of mitochondrial RNA processing endoribonuclease	Homo sapiens	30-35
35372520-10	2022	The results showed that hydrogen bonds mediated the interactions between ACE2 glycans and S protein with desialylated glycans forming significantly fewer hydrogen bonds.	Hydrogen	24-32	angiotensin converting enzyme 2	Homo sapiens	73-77
35372520-10	2022	The results showed that hydrogen bonds mediated the interactions between ACE2 glycans and S protein with desialylated glycans forming significantly fewer hydrogen bonds.	Hydrogen	154-162	angiotensin converting enzyme 2	Homo sapiens	73-77
35277567-3	2022	From the nuclear magnetic resonance results, the crystallographic configurations of 1H, 13C, and 14N in the cation changed at temperatures close to TC1 (336 K), whereas that of 113Cd in the anion shows significant changes at temperatures close to TC1 and TC2 (417 K).	Hydrogen	84-86	transcobalamin 2	Homo sapiens	255-258
16211494-0	2005	1H, 15N, and 13C chemical shift assignments of the human Sulfiredoxin (hSrx).	Hydrogen	0-2	sulfiredoxin 1	Homo sapiens	71-75
35350365-0	2022	Band Structure Engineering and Defect Passivation of Cu x Ag1-x InS2/ZnS Quantum Dots to Enhance Photoelectrochemical Hydrogen Evolution.	Hydrogen	118-126	dentin matrix acidic phosphoprotein 1	Rattus norvegicus	58-61
16055723-0	2005	Evidence for a Watson-Crick hydrogen bonding requirement in DNA synthesis by human DNA polymerase kappa.	Hydrogen	28-36	DNA polymerase kappa	Homo sapiens	83-103
35218492-0	2022	Ceria-doped SnO2 nanocubes for solar light-driven photocatalytic hydrogen production.	Hydrogen	65-73	strawberry notch homolog 1	Homo sapiens	12-15
15863042-0	2005	The relevant effect of an intramolecular hydrogen bond on the conformational equilibrium of cis-3-methoxycyclohexanol compared to trans-3-methoxycyclohexanol and cis-1,3-dimethoxycyclohexane.	Hydrogen	41-49	suppressor of cytokine signaling 3	Homo sapiens	92-97
35265585-7	2022	It was indicated that six complementarity-determining regions (CDRs) were involved in 4B9 scFv recognition, forming a narrow binding cavity, and FB1/FB2 could be inserted into this binding cavity stably through strong hydrogen bonds and other interactions.	Hydrogen	218-226	Protein DEHYDRATION-INDUCED 19 homolog 5	Zea mays	149-152
16852161-1	2005	The hydrogen electrode reaction involving hydride ion, H-, at a Zn electrode is investigated in a molten LiCl-KCl-LiH system at 673 K. The charge-transfer resistances were measured by electrochemical impedance spectroscopy in the overpotential region of 0.10 &lt; or = eta &lt; or = 0.35 V and over the H- concentrations of 1.5 x 10(-4) &lt; or = C(H)- &lt; or = 1.2 x 10(-3) mol cm(-3).	Hydrogen	4-12	endothelin receptor type A	Homo sapiens	269-272
35138508-4	2022	The simulation results indicated that there were differences in the interactions between the RBD and hACE2, including hydrogen bonding, salt bridge interactions, non-bonded interactions, and binding free energy differences among these variants.	Hydrogen	118-126	angiotensin converting enzyme 2	Homo sapiens	101-106
15941059-5	2005	Suspension state 1H NMR and 13C CP/MAS-NMR spectroscopies showed that the alkyl chains on the Sil-DSG are in gauche form and their mobility is strongly restricted at room temperature.	Hydrogen	17-19	STIL centriolar assembly protein	Homo sapiens	94-97
35202256-3	2022	The adsorption ratio of PSMPs (5 mg/L, 30 mL) by ZIF-67 reached up to 92.1%, and the PSMP adsorption equilibrium was achieved within 20 min at 298 K. The adsorption of PSMPs would be favored at a pH of 8, a PSMPs solution concentration of 5 mg/L, and a temperature of 298 K. Further analyses demonstrated that hydrogen bond interactions, pi-pi stacking, and electrostatic interactions played a crucial role in the adsorption of PSMPs by ZIF-67 in aqueous solutions.	Hydrogen	310-318	microseminoprotein, prostate associated	Homo sapiens	85-89
16649616-2	2005	In this paper, an attempt has been made to suggest a new parameter, defined on the basis of the relative activity of acetoclastic and hydrogen oxidising methanogens, to aid in evaluating the performance and stability of anaerobic reactors.	Hydrogen	134-142	activation induced cytidine deaminase	Homo sapiens	169-172
35060728-7	2022	While L-nl supports the aggregation of hIAPP by stabilizing the beta-sheet rich aggregates, D-nl interrupts hIAPP-hIAPP interactions via hydrogen bonding and hydrophobic interactions, thus obstructing the self-aggregation of hIAPP.	Hydrogen	137-145	islet amyloid polypeptide	Homo sapiens	39-44
35060728-7	2022	While L-nl supports the aggregation of hIAPP by stabilizing the beta-sheet rich aggregates, D-nl interrupts hIAPP-hIAPP interactions via hydrogen bonding and hydrophobic interactions, thus obstructing the self-aggregation of hIAPP.	Hydrogen	137-145	islet amyloid polypeptide	Homo sapiens	108-113
35060728-7	2022	While L-nl supports the aggregation of hIAPP by stabilizing the beta-sheet rich aggregates, D-nl interrupts hIAPP-hIAPP interactions via hydrogen bonding and hydrophobic interactions, thus obstructing the self-aggregation of hIAPP.	Hydrogen	137-145	islet amyloid polypeptide	Homo sapiens	114-119
15771418-1	2005	Introduction of a hydrophobic or hydrogen-bonding alkynyl group into the C5 position of the pyridyl ring of epibatidine and A-84543 significantly increased the selectivity for neuronal nicotinic acetylcholine receptors (nAChRs) containing beta2 subunits over nAChRs containing beta4 subunits (K(i) ratio up to 92000-fold).	Hydrogen	33-41	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	239-244
35110603-8	2022	Performed 50 ns of MD simulations on top three hits were retained the salient pi-stacking, Zn2+ coordination, hydrogen bonding, and hydrophobic interactions with catalytic residues from the active site pocket of HDAC3.	Hydrogen	110-118	histone deacetylase 3	Homo sapiens	212-217
35124382-17	2022	Moreover, Tan I interacted with BNIP3 and NIX through hydrogen bond.	Hydrogen	54-62	BCL2 interacting protein 3 like	Homo sapiens	42-45
15771418-1	2005	Introduction of a hydrophobic or hydrogen-bonding alkynyl group into the C5 position of the pyridyl ring of epibatidine and A-84543 significantly increased the selectivity for neuronal nicotinic acetylcholine receptors (nAChRs) containing beta2 subunits over nAChRs containing beta4 subunits (K(i) ratio up to 92000-fold).	Hydrogen	33-41	tubulin beta 3 class III	Homo sapiens	277-282
35111980-0	2022	Sensitive and resistant of the homologous disulfide-bridged proteins alpha-lactalbumin and lysozyme to attack of hydrogen-atoms, dithiothreitol and trifluoroacetic acid, examined by matrix-assisted laser desorption/ionization mass spectrometry.	Hydrogen	113-121	lysozyme C, tracheal isozyme	Bos taurus	91-99
15732965-1	2005	A dynamic 1H NMR study has been carried out on the fluxional motion of the symmetric chelating ligand 2,9-dimethyl-1,10-phenanthroline (Me2-phen) between nonequivalent exchanging sites in a variety of square-planar complexes of the type [Pt(Me)(Me2-phen)(PR3)]BArf, 1-14, (BArf = B[3,5-(CF3)2C6H3]4).	Hydrogen	10-12	proteinase 3	Homo sapiens	255-258
35050433-8	2022	The two lowest energy (C4H4)2V2(CO)7 structures include one with an agostic C-H-V interaction activating a hydrogen atom from one of the cyclobutadiene rings and another with a four-electron donor bridging eta2-micro-CO group with a short V-O bonding distance.	Hydrogen	107-115	DNA polymerase iota	Homo sapiens	206-210
16833414-4	2005	Hydrogen abstraction to form HO2 + SH is the dominant product channel and proceeds through a loose transition state well-described at the level of calculation employed.	Hydrogen	0-8	heme oxygenase 2	Homo sapiens	29-32
15772758-0	2005	1H, 15N, and 13C resonance assignment of the amino-terminal domain of the Tfb1 subunit of yeast TFIIH.	Hydrogen	0-2	TFIIH/NER complex subunit TFB1	Saccharomyces cerevisiae S288C	74-78
15638688-0	2005	Energetics of hydrogen coverage on group VIII transition metal surfaces and a kinetic model for adsorption/desorption.	Hydrogen	14-22	cytochrome c oxidase subunit 8A	Homo sapiens	41-45
15638688-1	2005	We determined the binding energy of hydrogen to the closest packed surface for all nine group VIII transition metals as a function of surface coverage using quantum mechanics (density functional theory with the generalized gradient approximation) with periodic boundary conditions.	Hydrogen	36-44	cytochrome c oxidase subunit 8A	Homo sapiens	94-98
15581350-2	2004	Analysis of the structural features common to CYP2C8 substrates exhibiting a micromolar K(m) led to a substrate pharmacophore in which the site of oxidation by CYP2C8 is 12.9, 8.6, 4.4, and 3.9 A from features that could establish ionic or hydrogen bonds, and hydrophobic interactions with protein amino acid residues.	Hydrogen	240-248	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	46-52
8642596-7	1996	Arg45(CD3) is also important for the dynamics of myoglobin, since it influences the pK(a) of His64 and forms a hydrogen bond lattice that hinders the rotation of His64 at neutral pH.	Hydrogen	111-119	myoglobin	Physeter catodon	49-58
8652550-8	1996	The hydrogen bond with the N delta 2 moiety of Asn 18 appears to be the most conserved interaction, being similar to those observed for sulfate ion bound to human basic FGF (bFGF) and similar but not identical to interactions observed for bovine aFGF with heparin analogs.	Hydrogen	4-12	fibroblast growth factor 1	Bos taurus	246-250
15581350-2	2004	Analysis of the structural features common to CYP2C8 substrates exhibiting a micromolar K(m) led to a substrate pharmacophore in which the site of oxidation by CYP2C8 is 12.9, 8.6, 4.4, and 3.9 A from features that could establish ionic or hydrogen bonds, and hydrophobic interactions with protein amino acid residues.	Hydrogen	240-248	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	160-166
15581350-6	2004	Serine 100 appears to be involved in hydrogen bonding interactions with a polar site of the CYP2C8 substrate pharmacophore, as shown by the 3-4-fold increase in the K(m) of paclitaxel and DMZ hydroxylation after the S100A mutation.	Hydrogen	37-45	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	92-98
15632987-0	2004	Hydrogen bonding in human p450-substrate interactions: a major contribution to binding affinity.	Hydrogen	0-8	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	26-30
8674617-0	1996	1H-NMb spectroscopy of beta-thiocyanatoalanine.	Hydrogen	0-2	neuromedin B	Homo sapiens	3-6
8745408-4	1996	The secondary structure of Ets-1 delta N280 was determined using NMR chemical shift, NOE, J coupling, and amide hydrogen exchange information.	Hydrogen	112-120	E26 avian leukemia oncogene 1, 5' domain	Mus musculus	27-32
15632987-1	2004	The importance of hydrogen bonding, a relatively strong intermolecular force of attraction between molecules in biological systems, is discussed in the respect of P450 substrate affinity towards one or more of the human P450 enzymes that are generally associated with drug and other xenobiotic metabolism.	Hydrogen	18-26	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	163-167
15632987-1	2004	The importance of hydrogen bonding, a relatively strong intermolecular force of attraction between molecules in biological systems, is discussed in the respect of P450 substrate affinity towards one or more of the human P450 enzymes that are generally associated with drug and other xenobiotic metabolism.	Hydrogen	18-26	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	220-224
15632987-3	2004	It is thus possible to estimate the hydrogen bond contribution to P450 enzyme-substrate binding affinity based on modelled interactions and by use of these relatively simple formulae, particularly when employed in conjunction with substrate-lipophilicity relationships.	Hydrogen	36-44	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	66-70
15345323-8	2004	In marked contrast, UCP3-/- animals developed a markedly blunted hyperthermic response at 1h compared to WT animals.	Hydrogen	90-92	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	20-24
8537345-3	1995	Two-dimensional 1H-13C shift correlation NMR spectra of recoverin containing a 13C-labeled myristoyl group were obtained to selectively probe the effect of Ca2+ on the environment of the attached myristoyl group.	Hydrogen	16-18	recoverin	Homo sapiens	56-65
8537345-7	1995	Furthermore, the 1H-13C shift correlation NMR spectrum of Ca(2+)-bound recoverin is very similar to that of myristic acid in solution.	Hydrogen	17-19	recoverin	Homo sapiens	71-80
8682024-4	1995	Granulocyte colony-stimulating factor 20 micrograms.kg-1.day-1, polyethylene glycol-conjugated superoxide dismutase (an enzyme catalyzing the conversion of O2- to H2(O2)) 1 x 10(3) U.kg-1.day-1 and granulocyte colony-stimulating factor 20 micrograms.kg-1.day-1, plus polyethylene glycol-conjugated superoxide dismutase 1 x 10(3) U. kg-1.	Hydrogen	163-165	colony stimulating factor 3 (granulocyte)	Mus musculus	0-37
8682024-4	1995	Granulocyte colony-stimulating factor 20 micrograms.kg-1.day-1, polyethylene glycol-conjugated superoxide dismutase (an enzyme catalyzing the conversion of O2- to H2(O2)) 1 x 10(3) U.kg-1.day-1 and granulocyte colony-stimulating factor 20 micrograms.kg-1.day-1, plus polyethylene glycol-conjugated superoxide dismutase 1 x 10(3) U. kg-1.	Hydrogen	163-165	colony stimulating factor 3 (granulocyte)	Mus musculus	198-235
15543946-9	2004	We conclude that these hydrogen bond interactions are critical for Jak2 kinase function and subsequent angiotensin II-dependent activation of the Jak/STAT signaling pathway.	Hydrogen	23-31	Janus kinase 2	Homo sapiens	67-71
15352223-9	2004	Furthermore, HR MAS 1H MR spectra facilitated refined detection of neuronal metabolites, including GABA, and composition of lipids in the autopsy brain tissue of NCL patients.	Hydrogen	20-22	nucleolin	Homo sapiens	162-165
7578231-9	1995	1H-NMR spectroscopy of the HMW complex formed between alpha-crystallin and gamma-crystallin indicates that the short C-terminal extension of alpha B-crystallin, but not that of alpha A-crystallin, has lost its flexibility in the complex implying that the former is involved in interactions with the unfolded gamma-crystallin molecule, possibly electrostatically via its two C-terminal lysine residues.	Hydrogen	0-2	crystallin alpha B	Bos taurus	141-159
7577928-1	1995	To test the hypothesis that pGlu of the thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2) binds to Asn289 in the third extracellular loop (EL3) of its receptor through a hydrogen bonding interaction, we converted Asn289 to Asp (N289D mutant) and measured the potencies of TRH and Pro1TRH for the wild-type and mutant receptors.	Hydrogen	173-181	thyrotropin releasing hormone	Rattus norvegicus	40-69
7577928-1	1995	To test the hypothesis that pGlu of the thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2) binds to Asn289 in the third extracellular loop (EL3) of its receptor through a hydrogen bonding interaction, we converted Asn289 to Asp (N289D mutant) and measured the potencies of TRH and Pro1TRH for the wild-type and mutant receptors.	Hydrogen	173-181	thyrotropin releasing hormone	Rattus norvegicus	71-74
15329726-4	2004	Glycosphingolipid binding specificity is achieved through recognition and anchoring of the sugar-amide headgroup to the GLTP recognition centre by hydrogen bond networks and hydrophobic contacts, and encapsulation of both lipid chains, in a precisely oriented manner within a "moulded-to-fit" hydrophobic tunnel.	Hydrogen	147-155	glycolipid transfer protein	Homo sapiens	120-124
12506420-8	1995	In conclusion, the results of these studies indicate that hydrogen ions are capable of evoking CGRP release from peripheral sensory neurons in rat antral mucosal/submucosal tissues.	Hydrogen	58-66	calcitonin-related polypeptide alpha	Rattus norvegicus	95-99
12506420-11	1995	These data suggest that proton-induced antral CGRP release represents a direct action of hydrogen ions on mucosal/submucosal sensory dendritic nerve endings to effect local release of neuropeptide.	Hydrogen	89-97	calcitonin-related polypeptide alpha	Rattus norvegicus	46-50
15265699-4	2004	Because sodium/hydrogen (Na(+)/H(+)) exchangers (NHEs) are known to regulate intracellular pH, melanocytes were treated with NHE inhibitors to determine what effect this inhibition might have on tyrosinase activity.	Hydrogen	15-23	solute carrier family 9 member C1	Homo sapiens	49-52
7479707-0	1995	Phe-46(CD4) orients the distal histidine for hydrogen bonding to bound ligands in sperm whale myoglobin.	Hydrogen	45-53	myoglobin	Physeter catodon	94-103
15287724-9	2004	Here, we describe the backbone dynamics of Cdc42Hs(F28L)-GDP using 1H-15N NMR measurements of T1, T1rho, and steady-state NOE at two magnetic field strengths.	Hydrogen	67-69	cell division cycle 42	Homo sapiens	43-50
7648581-0	1995	Substrate specificity of small-intestinal lactase: study of the steric effects and hydrogen bonds involved in enzyme-substrate interaction.	Hydrogen	83-91	lactase	Homo sapiens	42-49
22911578-6	1995	In a related series of experiments, the pH dependence of the hydrogen exchange rates of the epsilon-NH and eta-NH(2) protons of arginine was measured using saturation transfer (1)H NMR spectroscopy and compared with the equivalent NH(2) protons of the guanidinium ion.	Hydrogen	61-69	endothelin receptor type A	Homo sapiens	107-110
15273299-7	2004	The general-base-catalyzed hydroxyl proton abstraction from substrate concerted with hydride transfer to the C5 of PQQ is assisted by hydrogen-bonding to the C5=O by Wat1 and Arg 324 in MDH and by Wat89 and Arg 228 in sGDH.	Hydrogen	134-142	NADH:ubiquinone oxidoreductase subunit B5	Homo sapiens	218-222
15256704-6	2004	Docked paclitaxel was found to form a hydrogen bond with the side chain of Asn 99, which is a characteristic residue of CYP2C8 and is located in the additional pocket.	Hydrogen	38-46	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	120-126
7546038-11	1995	The reduced form of the coenzyme analogue also is a hydrogen donor with glutathione reductase.	Hydrogen	52-60	glutathione-disulfide reductase	Homo sapiens	72-93
15189034-1	2004	Although progesterone, the natural ligand of the progesterone receptor (PR), has a hydrogen atom at the 17alpha position, other potent steroid agonists such as norethindrone and mometasone furoate have larger substituents at this position that are accommodated by the PR ligand binding pocket.	Hydrogen	83-91	progesterone receptor	Homo sapiens	49-70
7797505-8	1995	1H-NMR spectroscopy confirmed that the oligosaccharide synthesized in vitro by the recombinant enzyme was the product of GnT II activity.	Hydrogen	0-2	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Rattus norvegicus	121-127
7752246-3	1995	Docking of the proline-rich peptide, 3BP1 on Grb2-N SH3, shows that the polyproline type II helix can bind the SH3 domain forming conserved hydrogen bonds between the main-chain carbonyl oxygens of Met4 and Pro7 of the proline-rich peptide and the reoriented side-chains of Trp36 and Asn51, respectively, and a hydrogen bond between the main-chain carbonyl of Leu8 of the proline rich peptide with the side-chain OH of Tyr52 of the Grb2-N SH3.	Hydrogen	140-148	SH3 domain binding protein 1	Homo sapiens	37-41
7752246-3	1995	Docking of the proline-rich peptide, 3BP1 on Grb2-N SH3, shows that the polyproline type II helix can bind the SH3 domain forming conserved hydrogen bonds between the main-chain carbonyl oxygens of Met4 and Pro7 of the proline-rich peptide and the reoriented side-chains of Trp36 and Asn51, respectively, and a hydrogen bond between the main-chain carbonyl of Leu8 of the proline rich peptide with the side-chain OH of Tyr52 of the Grb2-N SH3.	Hydrogen	311-319	SH3 domain binding protein 1	Homo sapiens	37-41
15189034-1	2004	Although progesterone, the natural ligand of the progesterone receptor (PR), has a hydrogen atom at the 17alpha position, other potent steroid agonists such as norethindrone and mometasone furoate have larger substituents at this position that are accommodated by the PR ligand binding pocket.	Hydrogen	83-91	progesterone receptor	Homo sapiens	72-74
15170341-0	2004	Role of hydrogen bonding in the active site of human manganese superoxide dismutase.	Hydrogen	8-16	superoxide dismutase 2	Homo sapiens	53-83
9970384-0	1995	eta meson photoproduction on hydrogen near threshold.	Hydrogen	29-37	endothelin receptor type A	Homo sapiens	0-3
7873520-5	1995	In order to characterize conformational dynamics of hTGF alpha on both the fast (i.e., sub-nanosecond) and intermediate nitrogen-15 chemical-exchange (i.e., microsecond) time scales, we measured nitrogen-15 relaxation parameters at pH 7.1 +/- 0.1 and a temperature of 30 +/- 0.5 degrees C. Measurements of nitrogen-15 longitudinal (R1) and transverse (R2) relaxation rates, and 1H-15N heteronuclear NOE effects, were then interpreted using an extended Lipari-Szabo analysis [Lipari, G., &amp; Szabo, A.	Hydrogen	378-380	transforming growth factor alpha	Homo sapiens	52-62
15170341-1	2004	The side chain of Gln143, a conserved residue in manganese superoxide dismutase (MnSOD), forms a hydrogen bond with the manganese-bound solvent and is critical in maintaining catalytic activity.	Hydrogen	97-105	superoxide dismutase 2	Homo sapiens	49-79
15170341-1	2004	The side chain of Gln143, a conserved residue in manganese superoxide dismutase (MnSOD), forms a hydrogen bond with the manganese-bound solvent and is critical in maintaining catalytic activity.	Hydrogen	97-105	superoxide dismutase 2	Homo sapiens	81-86
15170341-6	2004	The crystal structure of Y34F/W123F human MnSOD at 1.95 A resolution suggests that this effect is not related to a conformational change in the side chain of Gln143, which does not change orientation in Y34F/W123F, but rather to more subtle electronic effects due to the loss of hydrogen bonding to the carboxamide side chain of Gln143.	Hydrogen	279-287	superoxide dismutase 2	Homo sapiens	42-47
7621499-4	1995	Precipitation of phosphate-containing calcium fluoride crystals, CaF2(P), can cause severe reduction in the calcium ion concentration and release of hydrogen ions from the precipitated phosphate.	Hydrogen	149-157	CCR4-NOT transcription complex subunit 8	Homo sapiens	65-69
15170341-7	2004	Wild-type MnSOD containing Trp123 and Tyr34 has approximately the same thermal stability compared with mutants containing Phe at these positions, suggesting the hydrogen bonds formed by these residues have functional rather than structural roles.	Hydrogen	161-169	superoxide dismutase 2	Homo sapiens	10-15
15147186-4	2004	Two of the zinc coordinating cysteines in T-CDA form hydrogen bonds to the conserved residue Arg56, and this residue together with the dipole moments from two alpha-helices partially neutralizes the additional negative charge in the active site, leading to a catalytic activity similar to D-CDA.	Hydrogen	53-61	cytidine deaminase	Homo sapiens	42-47
15147186-4	2004	Two of the zinc coordinating cysteines in T-CDA form hydrogen bonds to the conserved residue Arg56, and this residue together with the dipole moments from two alpha-helices partially neutralizes the additional negative charge in the active site, leading to a catalytic activity similar to D-CDA.	Hydrogen	53-61	cytidine deaminase	Homo sapiens	44-47
15099746-10	2004	Mutation of Tyr92 to Phe92 in RNase A has no effect on its reductive unfolding pathway, suggesting that the hydrogen bond between the hydroxyl group of Tyr92 and the carbonyl group of Lys37 has no impact on the local unfolding free energy required to expose the (40-95) disulfide bond.	Hydrogen	108-116	ribonuclease A family member 1, pancreatic	Homo sapiens	30-37
7932578-5	1994	This heterocyclic nitrogen atom would provide a critical hydrogen-bond interaction with the histidine residue of the catalytic triad in PEP.	Hydrogen	57-65	prolyl endopeptidase	Homo sapiens	136-139
15267793-1	2004	We have probed under high pressure the C-H hydrogen bonds formed by N,N(")-disubstituted imidazolium ions having PF(6) (-) and Br(-) counterions.	Hydrogen	43-51	sperm associated antigen 17	Homo sapiens	113-118
15267793-3	2004	The appearance of a signal for the free-NH unit (or weakly bonded N-H...F unit) in the infrared spectrum of the PF(6) (-) salt indicates that conventional N-H...O and N-H...N hydrogen bonds do not fully dominate the packing.	Hydrogen	175-183	sperm associated antigen 17	Homo sapiens	112-117
15267793-4	2004	It is likely that the charge-enhanced C(2)-H...F interactions, combined with other weak hydrogen bonds, disturb the formation of N-H hydrogen bonds in the PF(6) (-) salt.	Hydrogen	88-96	sperm associated antigen 17	Homo sapiens	155-160
7824523-1	1994	The exchange kinetics for the slowly exchanging amide hydrogens in three defensins, rabbit NP-2, rabbit NP-5, and human HNP-1, have been measured over a range of pH at 25 degrees C using 1D and 2D NMR methods.	Hydrogen	54-63	corticostatin-4	Oryctolagus cuniculus	91-95
15267793-4	2004	It is likely that the charge-enhanced C(2)-H...F interactions, combined with other weak hydrogen bonds, disturb the formation of N-H hydrogen bonds in the PF(6) (-) salt.	Hydrogen	133-141	sperm associated antigen 17	Homo sapiens	155-160
15267793-7	2004	This finding suggests that the hydrogen bonding patterns are determined by the relative hydrogen bond acceptor strengths of the Br(-) and PF(6) (-) ions.	Hydrogen	31-39	sperm associated antigen 17	Homo sapiens	138-143
15267793-7	2004	This finding suggests that the hydrogen bonding patterns are determined by the relative hydrogen bond acceptor strengths of the Br(-) and PF(6) (-) ions.	Hydrogen	88-96	sperm associated antigen 17	Homo sapiens	138-143
15115691-9	2004	Our data show that the medium with 25% HS was the best for cell expansion and cycling of the CD133- cells for the first week, followed by the 12.5% FCS+12.5% HS.	Hydrogen	39-41	prominin 1	Homo sapiens	93-98
8068628-0	1994	Assignments of 1H, 15N, and 13C resonances for the backbone and side chains of the N-terminal domain of DNA polymerase beta.	Hydrogen	15-17	DNA polymerase beta	Homo sapiens	104-123
15115691-10	2004	After 2 weeks of cultivation, obviously 12.5% HS and 12.5% FCS+12.5% HS exhibited similar S-phase amounts in CD133- cells.	Hydrogen	46-48	prominin 1	Homo sapiens	109-114
15115691-10	2004	After 2 weeks of cultivation, obviously 12.5% HS and 12.5% FCS+12.5% HS exhibited similar S-phase amounts in CD133- cells.	Hydrogen	69-71	prominin 1	Homo sapiens	109-114
8011640-0	1994	A very short hydrogen bond provides only moderate stabilization of an enzyme-inhibitor complex of citrate synthase.	Hydrogen	13-21	citrate synthase	Homo sapiens	98-114
15070370-0	2004	Hydrogenolysis of [PhBP3]Fe[triple bond]N-p-tolyl: probing the reactivity of an iron imide with H2.	Hydrogen	96-98	PHB1 pseudogene 3	Homo sapiens	19-24
7973820-0	1994	[Measurement of rCBF by hydrogen gas clearance with lower H2 concentration in rats].	Hydrogen	24-32	CCAAT/enhancer binding protein zeta	Rattus norvegicus	16-20
7973820-0	1994	[Measurement of rCBF by hydrogen gas clearance with lower H2 concentration in rats].	Hydrogen	58-60	CCAAT/enhancer binding protein zeta	Rattus norvegicus	16-20
7973820-1	1994	H2 clearance method in measuring regional cerebral blood flow (rCBF) on animals has been widely used in experimental research.	Hydrogen	0-2	CCAAT/enhancer binding protein zeta	Rattus norvegicus	63-67
7973820-4	1994	Repeated measurements of 3% H2 clearance for 1.5 min further showed that clearance test using low H2 concentration for short term periods reflected better the rCBF of experimental animals.	Hydrogen	28-30	CCAAT/enhancer binding protein zeta	Rattus norvegicus	159-163
8180157-0	1994	1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element.	Hydrogen	0-2	Rev	Human immunodeficiency virus 1	36-39
8180157-0	1994	1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element.	Hydrogen	0-2	Rev	Human immunodeficiency virus 1	60-63
8180157-1	1994	1H NMR studies of a 30-nucleotide RNA oligonucleotide (RBE3), which contains a high-affinity binding site for Rev of the HIV-1 Rev responsive element (RRE), two derivatives of RBE3 (RBE3AA and RBE3-A), and the complex of RBE3 with peptides derived from the RNA binding domain of HIV-1 Rev, are presented.	Hydrogen	0-2	Rev	Human immunodeficiency virus 1	110-113
8180157-1	1994	1H NMR studies of a 30-nucleotide RNA oligonucleotide (RBE3), which contains a high-affinity binding site for Rev of the HIV-1 Rev responsive element (RRE), two derivatives of RBE3 (RBE3AA and RBE3-A), and the complex of RBE3 with peptides derived from the RNA binding domain of HIV-1 Rev, are presented.	Hydrogen	0-2	Rev	Human immunodeficiency virus 1	127-130
15070370-2	2004	Pseudotetrahedral [PhBP3]FeIIIN-p-tolyl is reduced by hydrogen at ambient temperature and pressure in benzene solution.	Hydrogen	54-62	PHB1 pseudogene 3	Homo sapiens	19-24
8180157-1	1994	1H NMR studies of a 30-nucleotide RNA oligonucleotide (RBE3), which contains a high-affinity binding site for Rev of the HIV-1 Rev responsive element (RRE), two derivatives of RBE3 (RBE3AA and RBE3-A), and the complex of RBE3 with peptides derived from the RNA binding domain of HIV-1 Rev, are presented.	Hydrogen	0-2	Rev	Human immunodeficiency virus 1	127-130
15134829-3	2004	The extent and duration of IR endocytosis were markedly increased in response to the H2-analogue and [Asp(B10)]HI compared to wild-type HI, but similar to HI after [Glu(A13),Glu(B10)]HI administration.	Hydrogen	85-87	insulin receptor	Rattus norvegicus	27-29
7520293-4	1994	Furthermore, the asymmetry parameter, eta, of the electric field gradient tensor of the amide deuterons is large (approximately 0.2) and many of the amide groups are involved in hydrogen bonding, which is known to affect the quadrupole coupling constant.	Hydrogen	178-186	endothelin receptor type A	Homo sapiens	38-41
15134829-5	2004	A low cell-free endosome-lysosome transfer of the internalized IR was only observed in response to HI and H2-analogue injection.	Hydrogen	106-108	insulin receptor	Rattus norvegicus	63-65
15051172-5	2004	Four different interaction modes were observed, flavonoids are stabilised in S(1) region of beta-trypsin by formation of two (apigenin) or at least one hydrogen bond and other significant electrostatic interactions.	Hydrogen	152-160	serine protease 1	Homo sapiens	92-104
14981510-3	2004	The two TIS11d zinc fingers bind in a symmetrical fashion to adjacent 5"-UAUU-3" subsites on the single-stranded RNA via a combination of electrostatic and hydrogen-bonding interactions, with intercalative stacking between conserved aromatic side chains and the RNA bases.	Hydrogen	156-164	ZFP36 ring finger protein like 2	Homo sapiens	8-14
7510408-1	1994	Parallel measurements of the thermodynamics (free-energy, enthalpy, entropy and heat-capacity changes) of ligand binding to FK506 binding protein (FKBP-12) in H2O and D2O have been performed in an effort to probe the energetic contributions of single protein-ligand hydrogen bonds formed in the binding reactions.	Hydrogen	266-274	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	147-154
7510408-2	1994	Changing tyrosine-82 to phenylalanine in FKBP-12 abolishes protein-ligand hydrogen bond interactions in the FKBP-12 complexes with tacrolimus or rapamycin and leads to a large apparent enthalpic stabilization of binding in both H2O and D2O.	Hydrogen	74-82	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	41-48
7510408-2	1994	Changing tyrosine-82 to phenylalanine in FKBP-12 abolishes protein-ligand hydrogen bond interactions in the FKBP-12 complexes with tacrolimus or rapamycin and leads to a large apparent enthalpic stabilization of binding in both H2O and D2O.	Hydrogen	74-82	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	108-115
14981510-4	2004	Sequence specificity in RNA recognition is achieved by a network of intermolecular hydrogen bonds, mostly between TIS11d main-chain functional groups and the Watson-Crick edges of the bases.	Hydrogen	83-91	ZFP36 ring finger protein like 2	Homo sapiens	114-120
14712082-6	2004	CAIX has a major role in regulating hydrogen ion (H+) flux and blockade of CAIX results in increased cell death under hypoxia, indicating that it is one mechanism of hypoxic adaptation.	Hydrogen	36-44	carbonic anhydrase 9	Homo sapiens	0-4
8142460-16	1994	1H-NMR spectroscopy of mixtures of alpha- and beta L-crystallin, in their native states, reveals that the C-terminus of beta B2-crystallin is involved in interaction with alpha-crystallin.	Hydrogen	0-2	crystallin beta B2	Bos taurus	120-138
8003969-3	1994	P44 should be stabilized by intrahelical hydrogen bonds, interhelical disulfide and salt bridges, and interior hydrophobic interactions.	Hydrogen	41-49	interferon induced protein 44	Homo sapiens	0-3
14741391-2	2004	To investigate the localizing mechanism of this cortical injury, we spatiotemporally detected the cortical intracellular calcium changes, as revealed by a calcium-sensitive fluorescence dye, Rhod 2-AM, during 1h of HI on postnatal days 7-21 in vivo.	Hydrogen	209-211	ras homolog family member D	Rattus norvegicus	191-195
8003969-10	1994	These simulations revealed the presence of 2 local hydrogen bond networks involving intra-helical 3-center hydrogen bonds in the hydrophobic interior of the coiled coils of GCN4 and P44.	Hydrogen	51-59	interferon induced protein 44	Homo sapiens	182-185
8003969-10	1994	These simulations revealed the presence of 2 local hydrogen bond networks involving intra-helical 3-center hydrogen bonds in the hydrophobic interior of the coiled coils of GCN4 and P44.	Hydrogen	107-115	interferon induced protein 44	Homo sapiens	182-185
14730962-0	2004	EX1 hydrogen exchange and protein folding.	Hydrogen	4-12	FERM domain containing 6	Homo sapiens	0-3
8148794-6	1994	These results suggest that 1H-NMR spectroscopy of CSF can become a powerful aid in biochemical diagnosis of CNS diseases.	Hydrogen	27-29	activation induced cytidine deaminase	Homo sapiens	76-79
7779404-8	1994	The arginine at position 41 is the most critical residue and its full hydrogen-bonding capacity is needed for strong binding of EGF/TGF-alpha to the EGF-receptor.	Hydrogen	70-78	transforming growth factor alpha	Homo sapiens	132-141
7953289-2	1994	A proposed mechanism of ligand-activated trans-membrane proton transfer within alpha-helices III, IV, V, VI and VII of the beta 1-adrenoceptor involving activation of a Tyr377-Arg156-Tyr157 proton shuttle by two hydrogen bond proton donor interactions of the natural ligand, nor-adrenaline is found to have an equivalent representation in the m2-muscarinic receptor.	Hydrogen	212-220	adrenoceptor beta 1	Homo sapiens	123-142
7953289-3	1994	Activation of Tyr377 in the beta 1-adrenoceptor is achieved by a direct hydrogen bond interaction of the para-hydroxy moiety and by an indirect action of the beta-hydroxyl group involving reversal of a hydrogen bond relay.	Hydrogen	72-80	adrenoceptor beta 1	Homo sapiens	28-47
7953289-3	1994	Activation of Tyr377 in the beta 1-adrenoceptor is achieved by a direct hydrogen bond interaction of the para-hydroxy moiety and by an indirect action of the beta-hydroxyl group involving reversal of a hydrogen bond relay.	Hydrogen	202-210	adrenoceptor beta 1	Homo sapiens	28-47
8218199-1	1993	A recombinant 75 amino acid polypeptide corresponding to the globular domain of the chicken histone H1 (GH1) has been studied by 1H homonuclear and 1H-15N heteronuclear 2D NMR spectroscopy.	Hydrogen	129-131	histone H1	Gallus gallus	92-102
8218199-1	1993	A recombinant 75 amino acid polypeptide corresponding to the globular domain of the chicken histone H1 (GH1) has been studied by 1H homonuclear and 1H-15N heteronuclear 2D NMR spectroscopy.	Hydrogen	129-131	growth hormone	Gallus gallus	104-107
8218199-1	1993	A recombinant 75 amino acid polypeptide corresponding to the globular domain of the chicken histone H1 (GH1) has been studied by 1H homonuclear and 1H-15N heteronuclear 2D NMR spectroscopy.	Hydrogen	148-150	growth hormone	Gallus gallus	104-107
8218200-0	1993	Metal ion binding to dog osteocalcin studied by 1H NMR spectroscopy.	Hydrogen	48-50	bone gamma-carboxyglutamate protein	Canis lupus familiaris	25-36
14730962-2	2004	The kinetic model for slow hydrogen exchange has two limits, called EX2 and EX1, wherein the thermodynamics and kinetics of protein motions, respectively, are reported by the exchange data.	Hydrogen	27-35	FERM domain containing 6	Homo sapiens	76-79
8218200-1	1993	One-dimensional 1H NMR was employed to study the effects of Ca2+ and Lu3+ binding on the apo and calcium-saturated forms of dog bone Gla protein (BGP, osteocalcin).	Hydrogen	16-18	bone gamma-carboxyglutamate protein	Canis lupus familiaris	128-144
14730962-4	2004	EX1 hydrogen exchange has advantages over more traditional folding experiments: it provides single-residue resolution, as well as whole-molecule information, the latter of which can be interpreted in terms of the cooperativity of unfolding.	Hydrogen	4-12	FERM domain containing 6	Homo sapiens	0-3
8409983-7	1993	The interaction appears to involve a hydrogen bond with the eta-protons of arginine"s guanido group acting as donor and tyrosine"s phenolic eta-oxygen as acceptor.	Hydrogen	37-45	endothelin receptor type A	Homo sapiens	60-63
14730972-9	2004	We conclude that hydrogen bonds to phosphate groups 3" to the cleavage site is essential for APE1"s binding to the product DNA, which may be necessary for efficient functioning of the base excision repair pathway.	Hydrogen	17-25	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	93-97
8409983-7	1993	The interaction appears to involve a hydrogen bond with the eta-protons of arginine"s guanido group acting as donor and tyrosine"s phenolic eta-oxygen as acceptor.	Hydrogen	37-45	endothelin receptor type A	Homo sapiens	140-143
14695301-0	2004	Hydrogen-deuterium exchange effects on beta-endorphin release from AtT20 murine pituitary tumor cells.	Hydrogen	0-8	pro-opiomelanocortin-alpha	Mus musculus	39-53
8338831-2	1993	Homo- and heteronuclear NMR spectra were used to determine nearly complete sequence-specific 1H and 15N resonance assignments for hTGF alpha under three conditions: pH 6.5 and a temperature of 10 degrees C, pH 6.5 and a temperature of 30 degrees C, and pH 3.5 and a temperature of 30 degrees C. The 15N-enriched samples of hTGF alpha allowed determination of many 3J(HN-H alpha) vicinal coupling constants.	Hydrogen	93-95	transforming growth factor alpha	Homo sapiens	130-140
8374057-5	1993	We also report the solution-state 1H NMR assignment of the trans-syn-II photodimer of TpT and its (Rp)-methyl phosphate ester by way of 2D homonuclear Hartmann--Hahn experiment, rotating frame nuclear Overhauser effect spectroscopy, and proton-detected 1H-31P correlation spectroscopy.	Hydrogen	34-36	decaprenyl diphosphate synthase subunit 1	Homo sapiens	86-89
14971307-1	2003	The interaction of glimepiride with b-cyclodextrin (b-CD) has been studied by several analytical techniques, including 1H NMR, infrared spectroscopy (FTIR), powder x-ray diffractometry (XRD), thermal analysis (DSC) and scanning electron microscopy (SEM).	Hydrogen	119-121	cytochrome P450 family 4 subfamily V member 2	Homo sapiens	52-56
8496932-4	1993	Only replacement of amide bonds with isosterases having both hydrogen bond donor and acceptor functionalities yielded compounds retaining ACAT inhibitory activity.	Hydrogen	61-69	carboxylesterase 1	Homo sapiens	138-142
12975588-0	2003	1H, 13C, and 15N backbone assignment of the first two Ig domains Z1Z2 of the giant muscle protein Titin.	Hydrogen	0-2	titin	Homo sapiens	98-103
8503849-4	1993	The ionic forms are slightly more predominant in GPha than they are in GPhb, so ionic and/or hydrogen-bonding interactions between the aromatic ring of PLP and GPha must be stronger than with GPhb.	Hydrogen	93-101	glycoprotein hormones, alpha polypeptide	Homo sapiens	49-53
8503849-4	1993	The ionic forms are slightly more predominant in GPha than they are in GPhb, so ionic and/or hydrogen-bonding interactions between the aromatic ring of PLP and GPha must be stronger than with GPhb.	Hydrogen	93-101	glycoprotein hormones, alpha polypeptide	Homo sapiens	160-164
14667979-7	2003	The simulation revealed hPR-Cys891 as the sole but weak hydrogen bonding partner of progesterone in the D-ring.	Hydrogen	56-64	haptoglobin-related protein	Homo sapiens	24-27
7683727-7	1993	In CRBP, the all-trans-retinol has a planar conformation with its alcohol group hydrogen bonding to the side-chain of glutamine 108 (equivalent to residue 106 in P2).	Hydrogen	80-88	retinol binding protein 1	Homo sapiens	3-7
14521731-6	2003	RESULTS: Computer modeling showed the side chains of 263 (F), 266 (E) fit in the peptide binding groove, and form hydrogen bond with alpha1, beta1 chain of HLA-DR1.	Hydrogen	114-122	down-regulator of transcription 1	Mus musculus	160-163
8466903-1	1993	Activation of the enediyne neocarzinostatin chromophore (NCS-Chrom) by thiol addition at C-12 generates a diradical species with radical centers at C-2 and C-6, which abstract hydrogens from deoxyribose in the minor groove of DNA.	Hydrogen	176-185	complement C6	Homo sapiens	156-159
8477703-0	1993	1H-NMR spectroscopy of beta B2-crystallin from bovine eye lens.	Hydrogen	0-2	crystallin beta B2	Bos taurus	23-41
8477703-2	1993	1H-NMR spectroscopic studies of a 46-kDa homodimer, beta B2-crystallin, from bovine eye lens are presented.	Hydrogen	0-2	crystallin beta B2	Bos taurus	52-70
12924948-5	2003	We have now examined the importance of the hydrogen-bonding potential of residues in TM17 of MRP3 on both substrate specificity and overall activity.	Hydrogen	43-51	ATP binding cassette subfamily C member 3	Homo sapiens	93-97
8425536-0	1993	The cooperative binding of phenylalanine to phenylalanine 4-monooxygenase studied by 1H-NMR paramagnetic relaxation.	Hydrogen	85-87	phenylalanine hydroxylase	Homo sapiens	44-73
12899831-5	2003	This new interaction prevents the formation of a hydrogen bond with the cofactor, as seen in h3alpha-HSD3 ternary complexes.	Hydrogen	49-57	aldo-keto reductase family 1 member C2	Homo sapiens	94-105
8203280-3	1993	The rCBF was registered by the hydrogen clearance method with locally generated hydrogen.	Hydrogen	31-39	CCAAT/enhancer binding protein zeta	Rattus norvegicus	4-8
8203280-3	1993	The rCBF was registered by the hydrogen clearance method with locally generated hydrogen.	Hydrogen	80-88	CCAAT/enhancer binding protein zeta	Rattus norvegicus	4-8
12852944-2	2003	These compounds, particularly molecules with side-chain modifications providing additional hydrogen bonding capability, were demonstrated to be potent CDK2 inhibitors with cellular activities consistent with CDK2 inhibition.	Hydrogen	91-99	cyclin dependent kinase 2	Homo sapiens	151-155
8144705-3	1993	In the intercalated cell, hydrogen ion secretion into the urine is modulated by the recycling of vesicles carrying a proton pumping ATPase to and from the plasma membrane.	Hydrogen	26-34	dynein axonemal heavy chain 8	Homo sapiens	132-138
14503974-1	2003	Thioredoxin (Trx) and glutaredoxin (Grx) are dithiol redox enzymes, catalyzing general thiol-disulfide oxidoreductions apart from being hydrogen donors for ribonucleotide reductase, an enzyme essential for DNA synthesis.	Hydrogen	136-144	glutaredoxin	Homo sapiens	22-34
1282702-7	1992	The results provide strong evidence that the bubble structure contains specific configurations of non-Watson--Crick G:G and G:A base pairs and suggest that high affinity recognition of RRE RNA by rev requires hydrogen bonding to functional groups in the major groove of a distorted RNA structure.	Hydrogen	209-217	Rev	Human immunodeficiency virus 1	196-199
1433221-2	1992	Data from 2D NMR (HOHAHA and ROESY) provide short-range NOEs that are used as constraints in molecular modeling; measurement of coupling constants shows that chi 1 (D-AlaL2) is predominantly in either the t or g- conformation, and temperature coefficient data suggest the participation of the AlaL5 amide proton in an intramolecular hydrogen bond.	Hydrogen	333-341	glutamate ionotropic receptor NMDA type subunit 3A	Rattus norvegicus	158-163
14503974-1	2003	Thioredoxin (Trx) and glutaredoxin (Grx) are dithiol redox enzymes, catalyzing general thiol-disulfide oxidoreductions apart from being hydrogen donors for ribonucleotide reductase, an enzyme essential for DNA synthesis.	Hydrogen	136-144	glutaredoxin	Homo sapiens	36-39
1390737-4	1992	Visualization of these four regions on three-dimensional solution phase structures of hTGF alpha, derived from 1H NMR measurements [Kline, T.-P., Brown, F.K., Brown, S.C., Jeffs, P.W., Kopple, K.D., &amp; Mueller, L. (1990) Biochemistry 29, 7805-7813], indicated that the peptide segments are located on a single face of the protein and suggested the presence of a potential receptor binding cavity.	Hydrogen	111-113	transforming growth factor alpha	Homo sapiens	86-96
12837059-0	2003	Solution 1h NMR characterization of equilibrium heme orientational disorder with functional consequences in mouse neuroglobin.	Hydrogen	9-11	neuroglobin	Mus musculus	114-125
1384749-6	1992	Addition of solutions containing Ca2+ or Mg2+ to the poly(Glu)/poly(Lys) aggregates resulted in complete dissolution of the gel, with the disappearance of the ir bands characteristic of the intermolecular hydrogen-bonded network.	Hydrogen	205-213	mucin 7, secreted	Homo sapiens	41-44
12837059-1	2003	The solution 1H NMR spectrum of oxidized (met) mouse neuroglobin, metNgb, demonstrates that it is low-spin and hexacoordinate with strong spectral similarities to ferricytochrome b5.	Hydrogen	13-15	neuroglobin	Mus musculus	53-64
12906550-0	2003	Electron- or hole-assisted reactions of H defects in hydrogen-bonded KDP.	Hydrogen	53-61	WNK lysine deficient protein kinase 1	Homo sapiens	69-72
1358850-0	1992	Conformational studies of N-Tyr-MIF-1 in aqueous solution by 1H nuclear magnetic resonance spectroscopy.	Hydrogen	61-63	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	32-37
1358850-3	1992	In this report, we studied the conformation of N-Tyr-MIF-1 in aqueous solution by conventional one-dimensional and two-dimensional (COSY and NOESY) 1H nuclear magnetic resonance spectroscopy at 300 MHz.	Hydrogen	148-150	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	53-58
1349525-2	1992	1H-NMR structural studies of phosphoglycerate kinase in the presence of varying concentrations of these large molecules (designed to mimic, at one end, the anionic charge distribution in the substrate 3-phosphoglycerate, while possibly being able to interact across the cleft of the enzyme) including inositol 1,4,5-triphosphate, 4-amino-6-trichloroethenyl-1,3- benzenedisulphonamide, gallic acid and sulphasalazine are described.	Hydrogen	0-2	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	29-52
12890378-0	2003	Caspase-3 and its inhibitor Ac-DEVD-CHO in rat lens epithelial cell apoptosis induced by hydrogen in vitro.	Hydrogen	89-97	caspase 3	Rattus norvegicus	0-9
1560535-6	1992	This interaction would cause widening of the major groove of the RNA, thereby exposing its hydrogen-bonding surfaces for possible interaction with Tat.	Hydrogen	91-99	tyrosine aminotransferase	Homo sapiens	147-150
12855330-5	2003	When CGRP(8-37) was administered 1h after capsaicin injection, the mechanical allodynia and hyperalgesia were partially reversed in a dose-dependent manner.	Hydrogen	33-35	calcitonin-related polypeptide alpha	Rattus norvegicus	5-9
12673771-1	2003	A biohydrogen production system coupling the polysaccharide such as sucrose and maltose degradation with invertase and glucose dehydrognase (GDH) and hydrogen production with colloidal platinum as hydrogen-evolved catalyst using the visible light-induced photosensitization of water-soluble zinc porphyrin, zinc tetraphenylporphyrin tetrasulfonate (ZnTPPS) has been investigated.	Hydrogen	5-13	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	119-139
20720844-1	1992	We have determined the relationship between residual proton (hydrogen) concentration and optical absorption at 1.06 microm in highly deuterated potassium dihydrogen phosphate (KDP).	Hydrogen	61-69	WNK lysine deficient protein kinase 1	Homo sapiens	176-179
20720844-4	1992	In addition, the KDP crystals we tested have residual (hydrogen-independent) o- and e-polarized absorbances of 958 +/- 228 ppm cm(-1) and 343 +/- 28 ppm cm(-1), respectively, whose origin is unknown.	Hydrogen	55-63	WNK lysine deficient protein kinase 1	Homo sapiens	17-20
12673771-1	2003	A biohydrogen production system coupling the polysaccharide such as sucrose and maltose degradation with invertase and glucose dehydrognase (GDH) and hydrogen production with colloidal platinum as hydrogen-evolved catalyst using the visible light-induced photosensitization of water-soluble zinc porphyrin, zinc tetraphenylporphyrin tetrasulfonate (ZnTPPS) has been investigated.	Hydrogen	5-13	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	141-144
1525855-7	1992	The mutational effect of the observed amino-acid substitution in ts2281 is discussed in terms of weakened hydrogen bonding in the C-terminal half of the MSW1-encoded protein.	Hydrogen	106-114	tryptophan--tRNA ligase MSW1	Saccharomyces cerevisiae S288C	153-157
12673771-2	2003	Continuous hydrogen gas production was observed when the sample solution containing polysaccharide, invertase, GDH, nicotinamide adenine dinucreotide (NAD(+)), ZnTPPS, methylviologen (an electron relay reagent), and colloidal platinum was irradiated by visible light.	Hydrogen	11-19	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	111-114
12741842-0	2003	Hydrogen exchange kinetics of RNase A and the urea:TMAO paradigm.	Hydrogen	0-8	ribonuclease A family member 1, pancreatic	Homo sapiens	30-37
1606356-8	1992	1H-NMR spectroscopy (400 MHz) of the glycan chains, alpha 6-sialylated in vitro, showed that the enzyme highly prefers the galactosyl residue at the Gal beta 1----4GlcNAc beta 1----2-Man alpha 1----3Man branch for attachment of the first mol of sialic acid into the diantennary glycans of desialylated hCG.	Hydrogen	0-2	chorionic gonadotropin subunit beta 5	Homo sapiens	302-305
12826726-6	2003	It shows the details of the C-terminal residues of TCS-C7, and in particular the hydrogen bonds between P35 and L240, S196 and L240, and W192 and L239, which play an important role in maintaining the structure of TCS-C7.	Hydrogen	81-89	treacle ribosome biogenesis factor 1	Homo sapiens	213-219
1542107-3	1992	The cis-trans isomerization occurs at the peptide bond between Gly42 and Pro43, which is in agreement with results from two-dimensional 1H nuclear magnetic resonance spectroscopy experiments on solutions of calbindin D9k.	Hydrogen	136-138	S100 calcium binding protein G	Bos taurus	207-220
12578822-4	2003	A striking feature of the C/EBPalpha protein-DNA interface that distinguishes it from known bZIP-DNA complexes is the central role of Arg(289), which is hydrogen-bonded to base A(3), phosphate, Asn(292) (invariant in bZIPs), and Asn(293).	Hydrogen	153-161	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	26-36
1731074-2	1992	We have determined, via 1H-n.m.r., the solution conformation of the collagen-binding b-domain of the bovine seminal fluid protein PDC-109 (PDC-109/b).	Hydrogen	24-26	seminal plasma protein PDC-109	Bos taurus	130-137
1792946-2	1991	Diminished lactase activity, defined as greater than 20 ppm increase in expired hydrogen at 2 or 2.5 h after an oral lactose load, was examined: (1) by comparing bone mass between members of twin pairs discordant for lactase activity; (2) by examining the linear association between bone mass and total expired hydrogen gas; and (3) by comparing all lactase-deficient individuals to those with persistent lactase activity.	Hydrogen	80-88	lactase	Homo sapiens	11-18
1792946-2	1991	Diminished lactase activity, defined as greater than 20 ppm increase in expired hydrogen at 2 or 2.5 h after an oral lactose load, was examined: (1) by comparing bone mass between members of twin pairs discordant for lactase activity; (2) by examining the linear association between bone mass and total expired hydrogen gas; and (3) by comparing all lactase-deficient individuals to those with persistent lactase activity.	Hydrogen	311-319	lactase	Homo sapiens	11-18
12643766-8	2003	The proposed model based on our experimental data indicated that the LFA-1 peptide interacts with the protein via three intermolecular hydrogen bonds.	Hydrogen	135-143	integrin subunit alpha L	Homo sapiens	69-74
1958667-4	1991	Evidence for the presence of the binuclear cluster has come from 113Cd NMR and 2D 1H-113Cd heteronuclear NMR studies of the cloned DNA-binding domain of GAL4 consisting of the N-terminal 62 residues, GAL4(62*) [Pan and Coleman (1990) Proc.	Hydrogen	82-84	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	153-157
1958667-15	1991	The metal ions also determine the major folding of GAL4(62*), since the chemical shift dispersion in the entire NH-alpha CH fingerprint region of the 1H-1H COSY spectrum collapses on removal of the metal ion.	Hydrogen	150-152	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	51-55
1958667-15	1991	The metal ions also determine the major folding of GAL4(62*), since the chemical shift dispersion in the entire NH-alpha CH fingerprint region of the 1H-1H COSY spectrum collapses on removal of the metal ion.	Hydrogen	153-155	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	51-55
12578357-2	2003	Previous studies showed that tight binding of RNase A and angiogenin (Ang) is achieved primarily through interactions of hot spot residues in the 434-460 C-terminal segment of RI with the enzymatic active site; Asp435 of RI forms key hydrogen bonds with the catalytic lysine in both complexes, whereas the other contacts are largely distinctive.	Hydrogen	234-242	ribonuclease A family member 1, pancreatic	Homo sapiens	46-53
1920440-6	1991	Water molecules interacting with alpha-helices occur mainly at the amino and carbonyl termini of the helices, in which case the solvent sites maintain the hydrogen bonding by bridging between residues i and i-3 or i-4 at the amino terminus and between i and i+3 or i+4 at the carbonyl terminus.	Hydrogen	155-163	brain protein I3	Homo sapiens	207-210
1889405-2	1991	Escherichia coli glutaredoxin (85 amino acid residues, Mr = 9100), the glutathione-dependent hydrogen donor for ribonucleotide reductase, was purified from an inducible lambda PL, expression system both with a natural isotope content and with uniform 15N labelling.	Hydrogen	93-101	glutaredoxin	Homo sapiens	17-29
12578357-2	2003	Previous studies showed that tight binding of RNase A and angiogenin (Ang) is achieved primarily through interactions of hot spot residues in the 434-460 C-terminal segment of RI with the enzymatic active site; Asp435 of RI forms key hydrogen bonds with the catalytic lysine in both complexes, whereas the other contacts are largely distinctive.	Hydrogen	234-242	angiogenin	Homo sapiens	58-68
12578357-2	2003	Previous studies showed that tight binding of RNase A and angiogenin (Ang) is achieved primarily through interactions of hot spot residues in the 434-460 C-terminal segment of RI with the enzymatic active site; Asp435 of RI forms key hydrogen bonds with the catalytic lysine in both complexes, whereas the other contacts are largely distinctive.	Hydrogen	234-242	angiogenin	Homo sapiens	70-73
12926258-3	2003	The 1H NMR spectra of the aminonitriles 2b-d showed an epimeric mixture at C-6.	Hydrogen	4-6	complement C6	Homo sapiens	75-78
1907570-2	1991	Tetraantennary oligosaccharides containing extra N-acetyllactosamine units were digested with endo-beta-galactosidase, followed by treatment with N-acetyl-beta-glucosaminidase, yielding products which could be analysed by 1H-NMR spectroscopy, thereby giving conclusive data about the location of the extra units in the intact structures.	Hydrogen	222-224	galactosidase beta 1	Homo sapiens	99-117
12567002-0	2003	1H, 13C and 15N resonance assignments of the catalytic domain of human MAPK phosphatase, PAC-1.	Hydrogen	0-2	dual specificity phosphatase 2	Homo sapiens	89-94
1907570-2	1991	Tetraantennary oligosaccharides containing extra N-acetyllactosamine units were digested with endo-beta-galactosidase, followed by treatment with N-acetyl-beta-glucosaminidase, yielding products which could be analysed by 1H-NMR spectroscopy, thereby giving conclusive data about the location of the extra units in the intact structures.	Hydrogen	222-224	O-GlcNAcase	Homo sapiens	146-175
1799376-3	1991	During in vivo daily treatment with sublethal doses of Monocrotophos, the MAO activity was significantly inhibited after 1h to 7 days of treatments.	Hydrogen	121-123	monoamine oxidase A	Rattus norvegicus	74-77
12567003-0	2003	Assignment of 1H, 13C and 15N resonances of the N-terminal microtubule-binding domain of human doublecortin.	Hydrogen	14-16	doublecortin	Homo sapiens	95-107
12691376-1	2003	Sodium-hydrogen ion exchange (NHE) is one of the principal mechanisms of restoring intracellular pH following ischemia and reperfusion.	Hydrogen	7-15	solute carrier family 9 member C1	Homo sapiens	30-33
1709522-6	1991	Model building suggests that the arginine eta nitrogens and the epsilon nitrogen can form specific networks of hydrogen bonds with adjacent pairs of phosphates and that these arrangements are likely to occur near RNA loops and bulges and not within double-stranded A-form RNA.	Hydrogen	111-119	endothelin receptor type A	Homo sapiens	42-45
1666528-3	1991	Results are presented in which hydrogen-exchange electrospray-ionization mass spectrometry is used to probe conformational changes in bovine ubiquitin induced by the addition of methanol to aqueous acidic solutions of the protein.	Hydrogen	31-39	ubiquitin	Bos taurus	141-150
1993209-9	1991	We conclude that the presence of carbon at the 5-position of tetrahydrofolate analogues is sufficient for inhibition of GARFT, that N-8 and the 2-amino group are involved in binding of DDATHF to GARFT, probably through hydrogen bonds, and that the structures of the phenyl ring and amino acid side chain of DDATHF analogues are not primary determinants of GARFT inhibition by monoglutamate forms of these compounds.	Hydrogen	219-227	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	195-200
1993209-9	1991	We conclude that the presence of carbon at the 5-position of tetrahydrofolate analogues is sufficient for inhibition of GARFT, that N-8 and the 2-amino group are involved in binding of DDATHF to GARFT, probably through hydrogen bonds, and that the structures of the phenyl ring and amino acid side chain of DDATHF analogues are not primary determinants of GARFT inhibition by monoglutamate forms of these compounds.	Hydrogen	219-227	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	195-200
1905551-5	1991	A composite hydrogen-bonding environment is proposed for the TRH with respect to receptor binding.	Hydrogen	12-20	thyrotropin releasing hormone	Homo sapiens	61-64
1903136-9	1991	Only one strain, LA-1, which demonstrated low bile resistance and intermediate beta-galactosidase activity, was capable of significantly decreasing breath hydrogen values when 10(8) cfu/ml of milk was consumed.	Hydrogen	155-163	galactosidase beta 1	Homo sapiens	79-97
2265711-0	1990	Complete assignment of the 1H NMR spectrum and secondary structure of the DNA binding domain of GAL4.	Hydrogen	27-29	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	96-100
2265711-1	1990	Complete 1H NMR resonance assignments are presented for the cysteine rich region of the DNA binding domain of the yeast transcriptional activator GAL4.	Hydrogen	9-11	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	146-150
2194802-1	1990	1H-NMR measurements were made of solutions of yeast phosphoglycerate kinase containing the nucleotide substrate, ATP, and Mg2+ in varying concentrations in order to investigate the affect that the metal ion has on the mode of ATP binding to the enzyme.	Hydrogen	0-2	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	52-75
2200514-0	1990	1H NMR resonance assignments, secondary structure, and global fold of Apo bovine calbindin D9k.	Hydrogen	0-2	S100 calcium binding protein G	Bos taurus	81-94
2161685-9	1990	(C13-A14-C15) segment at pH 8.9 establishes that X5 and A14 are directed into the helix, partially stack on each other, and are not stabilized by intermolecular hydrogen bonds.	Hydrogen	161-169	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	56-59
1692019-3	1990	The 1H NMR spectrum of PZP shows relatively few sharp resonances, which, by analogy with human alpha 2-macroglobulin, probably arise from the proteolytically sensitive bait region.	Hydrogen	4-6	PZP alpha-2-macroglobulin like	Homo sapiens	23-26
9903722-0	1990	Autoionization rates and energy levels of triplet nf, v=1 Rydberg states of H2.	Hydrogen	76-78	immunoglobulin kappa variable 1-5	Homo sapiens	54-57
2318818-0	1990	Mutagenesis of a single hydrogen bond in cytochrome P-450 alters cation binding and heme solvation.	Hydrogen	24-32	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	52-57
33815808-13	2021	Non-bonded distance was found to be short enough to form hydrogen bonding or hydrophobic interactions which revealed that these target compounds can strongly bind with RdRp.	Hydrogen	57-65	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	168-172
33777703-10	2021	The compounds also exhibited high binding affinities and molecular interactions with the active site amino acid residues of Drosophila GST and the inhibitor binding site of Drosophila AChE in an in silico molecular docking analysis, with BPDE forming stable hydrogen bonds with AChE.	Hydrogen	258-266	Acetylcholine esterase	Drosophila melanogaster	184-188
33778193-7	2021	SAMs-NH2 and SAMs-COOH could adsorb Fn efficiently via vdW interactions, electrostatic interactions, hydrogen bonds and salt bridges.	Hydrogen	101-109	methionine adenosyltransferase 1A	Homo sapiens	0-4
33778193-7	2021	SAMs-NH2 and SAMs-COOH could adsorb Fn efficiently via vdW interactions, electrostatic interactions, hydrogen bonds and salt bridges.	Hydrogen	101-109	methionine adenosyltransferase 1A	Homo sapiens	13-17
19914718-4	2010	NF-kappaB p65 and TNF-alpha were elevated at both 10 min and 1h post exposure.	Hydrogen	61-63	RELA proto-oncogene, NF-kB subunit	Homo sapiens	10-13
34872779-5	2022	Moreover, hydrogen bonding, pi-pi bonding, pore-filling, electrostatic interactions and chemisorption were proposed as possible mechanisms for the removal of dyes onto CS/MOF-235.	Hydrogen	10-18	citrate synthase	Homo sapiens	168-170
34863551-3	2022	The conduction band of Bi4MoO9 nanoparticles is calculated to be -1.55 eV versus the normal hydrogen electrode (NHE), pH = 7, which is negative enough to attain the photocatalytic CO2 reduction potential of -0.53 eV versus NHE, pH = 7.	Hydrogen	92-100	solute carrier family 9 member C1	Homo sapiens	112-115
34863551-3	2022	The conduction band of Bi4MoO9 nanoparticles is calculated to be -1.55 eV versus the normal hydrogen electrode (NHE), pH = 7, which is negative enough to attain the photocatalytic CO2 reduction potential of -0.53 eV versus NHE, pH = 7.	Hydrogen	92-100	solute carrier family 9 member C1	Homo sapiens	223-226
34955621-7	2022	The increase in the number of interface residues, interface area and intermolecular forces such as hydrogen bonds, salt bridges and non-bonded contacts corroborated with the increase in the binding affinity of the spike mutants to ACE2.	Hydrogen	99-107	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	214-219
34955621-7	2022	The increase in the number of interface residues, interface area and intermolecular forces such as hydrogen bonds, salt bridges and non-bonded contacts corroborated with the increase in the binding affinity of the spike mutants to ACE2.	Hydrogen	99-107	angiotensin converting enzyme 2	Homo sapiens	231-235
34955621-8	2022	Further, 75 ns all-atom molecular dynamics simulation investigations show variations in the geometric properties such as root mean square deviation (RMSD), radius of gyration (Rg), total solvent accessible surface area (SASA) and number of hydrogen bonds (NHBs) in the mutant spike:ACE2 complexes with respect to the native spike:ACE2 complex.	Hydrogen	240-248	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	276-281
34955621-8	2022	Further, 75 ns all-atom molecular dynamics simulation investigations show variations in the geometric properties such as root mean square deviation (RMSD), radius of gyration (Rg), total solvent accessible surface area (SASA) and number of hydrogen bonds (NHBs) in the mutant spike:ACE2 complexes with respect to the native spike:ACE2 complex.	Hydrogen	240-248	angiotensin converting enzyme 2	Homo sapiens	282-286
34968782-6	2022	The mutations at the ACE2-RBD interface enhance the tight binding by increasing hydrogen bonding interaction and enlarging buried solvent accessible surface area.	Hydrogen	80-88	angiotensin converting enzyme 2	Homo sapiens	21-25
2573599-2	1989	High resolution 1H nuclear magnetic resonance spectroscopy and optical stopped-flow techniques have been used to study the metal binding properties of a site-specific mutant of bacterial recombinant oncomodulin in which glutamate has replaced a liganding aspartate at position 59 in the CD calcium-binding site.	Hydrogen	16-18	oncomodulin	Rattus norvegicus	199-210
2690076-0	1989	Conformational characterization of a single-site mutant of murine epidermal growth factor (EGF) by 1H NMR provides evidence that leucine-47 is involved in the interactions with the EGF receptor.	Hydrogen	99-101	epidermal growth factor	Mus musculus	91-94
2690076-0	1989	Conformational characterization of a single-site mutant of murine epidermal growth factor (EGF) by 1H NMR provides evidence that leucine-47 is involved in the interactions with the EGF receptor.	Hydrogen	99-101	epidermal growth factor	Mus musculus	181-184
9991696-0	1989	Gd3+ exchange interaction as measured by NMR in hydrogen-doped GdBa2Cu3O7H1.55.	Hydrogen	48-56	GRDX	Homo sapiens	0-3
2602487-3	1989	Since the activity of the enzyme lactase is low in almost all species, lactose is fermented by colonic bacteria after it arrived in the cecum, thus producing hydrogen.	Hydrogen	158-166	lactase	Rattus norvegicus	33-40
2684271-1	1989	Two-dimensional 1H NMR spectroscopy has been applied to a structural analysis of the reduced form of a recombinant human thioredoxin, a ubiquitous dithiol oxidoreductase recently isolated from an immunocompetent lymphoblastoid cell line.	Hydrogen	16-18	thioredoxin	Homo sapiens	121-132
2753043-0	1989	Preliminary assignments of the aromatic and some methyl group resonances of the 1H-NMR spectrum of the oxidized form of uteroglobin.	Hydrogen	80-82	secretoglobin family 1A member 1	Homo sapiens	120-131
2753043-2	1989	Two-dimensional NMR methods have been used to assign aromatic and methyl group resonances in the 1H-NMR spectrum of oxidized uteroglobin.	Hydrogen	97-99	secretoglobin family 1A member 1	Homo sapiens	125-136
2734314-6	1989	The fractional glucose C-1 enrichment of plasma glucose samples was analyzed by 1H NMR spectroscopy and confirmed by gas chromatography/mass spectroscopy.	Hydrogen	80-82	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	23-26
2725018-4	1989	Intracellular pH (pHi) was changed by manipulating the bicarbonate/CO2 ratio of the incubation medium, or by adding amiloride, a hydrogen/sodium antiport blocker.	Hydrogen	129-137	glucose-6-phosphate isomerase	Rattus norvegicus	14-16
2725018-4	1989	Intracellular pH (pHi) was changed by manipulating the bicarbonate/CO2 ratio of the incubation medium, or by adding amiloride, a hydrogen/sodium antiport blocker.	Hydrogen	129-137	glucose-6-phosphate isomerase	Rattus norvegicus	18-21
9947441-0	1989	Hydrogen hopping rates and hydrogen-hydrogen interactions in PdHx.	Hydrogen	0-8	pyruvate dehydrogenase complex component X	Homo sapiens	61-65
9947441-0	1989	Hydrogen hopping rates and hydrogen-hydrogen interactions in PdHx.	Hydrogen	27-35	pyruvate dehydrogenase complex component X	Homo sapiens	61-65
9947441-0	1989	Hydrogen hopping rates and hydrogen-hydrogen interactions in PdHx.	Hydrogen	36-44	pyruvate dehydrogenase complex component X	Homo sapiens	61-65
2540029-0	1989	NMR study of the alkaline isomerization of ferricytochrome c. The pH-induced isomerization of horse heart cytochrome c has been studied by 1H NMR.	Hydrogen	139-141	cytochrome c, somatic	Equus caballus	48-60
2647502-4	1989	Ribonucleotide reductase provides growing cells with deoxyribonucleotides, necessary for DNA synthesis, and thioredoxin is an in vitro hydrogen donor.	Hydrogen	135-143	thioredoxin	Homo sapiens	108-119
2493647-1	1989	We have recently shown that the synthesis of cyclooxygenase [also called prostaglandin (PG) synthase or PG endoperoxide synthase; 8,11,14-icosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.1] in human dermal fibroblasts is markedly stimulated by the cytokine interleukin 1 (IL-1).	Hydrogen	154-162	interleukin 1 alpha	Homo sapiens	288-292
3186694-1	1988	We report here the in vivo observation of the imidazole protons (C-2 and C-4) of carnosine (beta-Ala-His) by 1H NMR at 4.7 T in human skeletal muscle.	Hydrogen	109-111	complement C2	Homo sapiens	65-68
3186694-1	1988	We report here the in vivo observation of the imidazole protons (C-2 and C-4) of carnosine (beta-Ala-His) by 1H NMR at 4.7 T in human skeletal muscle.	Hydrogen	109-111	complement C4A (Rodgers blood group)	Homo sapiens	73-76
3186694-4	1988	An in vivo titration curve of the C-2 proton resonance was determined by interleaving 1H and 31P NMR spectra after exhaustive exercise, during which muscle pH recovers from an acidic value of 6.1.	Hydrogen	86-88	complement C2	Homo sapiens	34-37
3242946-4	1988	The dissociation constant of the third ionizable POH group of dPGP was more than 2 pK units higher than that of PGP, indicating that the free glycerol hydroxyl group plays an important role in headgroup conformation and stabilization, perhaps through hydrogen bonding with the phosphate group(s).	Hydrogen	251-259	phosphoglycolate phosphatase	Homo sapiens	63-66
3169253-1	1988	Two-dimensional 1H NMR spectroscopy is used to examine the structure and mobility of cytochrome b5 in solution.	Hydrogen	16-18	cytochrome b5 type A	Homo sapiens	85-98
3138949-9	1988	This is an important precedent, because hydrogen abstraction from carbon-10 is a critical step in the lipoxygenase-catalyzed synthesis of 8- and 12-hydroperoxy-eicosatetraenoates (HPETEs) and for the conversion of 5- and 15-HPETEs to leukotrienes.	Hydrogen	40-48	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	102-114
2900690-1	1988	The incubation of murine splenocytes in recombinant interleukin 2 (IL-2) gives rise to both lymphokine-activated killer (LAK) cells capable of lysing fresh tumor cells and cells capable of mediating antibody-dependent cellular cytotoxicity (ADCC) in the presence of anti-H2 allosera.	Hydrogen	271-273	interleukin 2	Mus musculus	52-65
2900690-1	1988	The incubation of murine splenocytes in recombinant interleukin 2 (IL-2) gives rise to both lymphokine-activated killer (LAK) cells capable of lysing fresh tumor cells and cells capable of mediating antibody-dependent cellular cytotoxicity (ADCC) in the presence of anti-H2 allosera.	Hydrogen	271-273	interleukin 2	Mus musculus	67-71
3416869-5	1988	With RCA-I, the C-2 hydroxyl group forms two weak hydrogen bonds in the capacity of a hydrogen-bond acceptor and a donor.	Hydrogen	50-58	complement C2	Homo sapiens	16-19
3416869-5	1988	With RCA-I, the C-2 hydroxyl group forms two weak hydrogen bonds in the capacity of a hydrogen-bond acceptor and a donor.	Hydrogen	86-94	complement C2	Homo sapiens	16-19
3416869-6	1988	On the other hand, there is a strong hydrogen bond between the C-2 hydroxyl group of galactose, which acts as a donor, and a charged group on BSL-I.	Hydrogen	37-45	complement C2	Homo sapiens	63-66
3416869-7	1988	The C-2 hydroxyl group of the sugar is also a hydrogen-bond donor to APA.	Hydrogen	46-54	complement C2	Homo sapiens	4-7
3416869-8	1988	The lectins are involved in strong hydrogen bonds through charged groups with the C-3 and C-4 hydroxyl groups of galactose, with the latter serving as hydrogen-bond donors.	Hydrogen	35-43	complement C4A (Rodgers blood group)	Homo sapiens	90-93
3412366-3	1988	The repair of single-strand breaks was found to be slightly slower in xrs 5 over the first 20 min after X-ray exposure, but the level of repair of ssb reached after an incubation of 1h following X-ray exposure in xrs 5 was the same as in CHO K1.	Hydrogen	182-184	lupus La protein	Cricetulus griseus	147-150
12450372-0	2002	Energetics of hydrogen bond networks in RNA: hydrogen bonds surrounding G+1 and U42 are the major determinants for the tertiary structure stability of the hairpin ribozyme.	Hydrogen	14-22	small nucleolar RNA, C/D box 42A	Homo sapiens	80-83
3042394-9	1988	In the presence of 0.3 mM dithiothreitol, the bacterial thioredoxin can serve as hydrogen donor for B. ammoniagenes ribonucleotide reductase in vitro, indicating the presence of a functional ribonucleotide reductase-thioredoxin system in these bacteria.	Hydrogen	81-89	thioredoxin	Homo sapiens	56-67
3042394-9	1988	In the presence of 0.3 mM dithiothreitol, the bacterial thioredoxin can serve as hydrogen donor for B. ammoniagenes ribonucleotide reductase in vitro, indicating the presence of a functional ribonucleotide reductase-thioredoxin system in these bacteria.	Hydrogen	81-89	thioredoxin	Homo sapiens	216-227
12450372-0	2002	Energetics of hydrogen bond networks in RNA: hydrogen bonds surrounding G+1 and U42 are the major determinants for the tertiary structure stability of the hairpin ribozyme.	Hydrogen	45-53	small nucleolar RNA, C/D box 42A	Homo sapiens	80-83
12450372-4	2002	To elucidate the determinants for tertiary structure stability in the hairpin ribozyme, we evaluated the energetic contributions of hydrogen bonds surrounding U42 and G+1 by time-resolved fluorescence resonance energy transfer using modified ribozymes that lack one or more of the individual interactions.	Hydrogen	132-140	small nucleolar RNA, C/D box 42A	Homo sapiens	159-162
3418713-4	1988	(4) From (3), the free energy of transferring the non-hydrogen bonded (C=O, H-N) group from water to CCl4 was calculated.	Hydrogen	54-62	C-C motif chemokine ligand 4	Homo sapiens	101-105
12450372-6	2002	The results of double- and triple-mutant cycles suggest that individual hydrogen bonds surrounding G+1 or U42 act cooperatively and form extended hydrogen bond networks that stabilize the docked ribozyme.	Hydrogen	72-80	small nucleolar RNA, C/D box 42A	Homo sapiens	106-109
12450372-6	2002	The results of double- and triple-mutant cycles suggest that individual hydrogen bonds surrounding G+1 or U42 act cooperatively and form extended hydrogen bond networks that stabilize the docked ribozyme.	Hydrogen	146-154	small nucleolar RNA, C/D box 42A	Homo sapiens	106-109
12405812-1	2002	A family of chiral organometallic triangles based on cis-Pt(PEt3)2 metallocorners and enantiopure atropisomeric bis(alkynyl) bridging ligands (L1-4) has been synthesized and characterized by 1H, 13C{1H}, and 31P{1H} NMR, UV-vis, and circular dichroism (CD) spectroscopies, FAB and MALDI-TOF mass spectrometry, and microanalysis.	Hydrogen	199-201	immunoglobulin kappa variable 1D-17	Homo sapiens	143-147
12405812-1	2002	A family of chiral organometallic triangles based on cis-Pt(PEt3)2 metallocorners and enantiopure atropisomeric bis(alkynyl) bridging ligands (L1-4) has been synthesized and characterized by 1H, 13C{1H}, and 31P{1H} NMR, UV-vis, and circular dichroism (CD) spectroscopies, FAB and MALDI-TOF mass spectrometry, and microanalysis.	Hydrogen	199-201	immunoglobulin kappa variable 1D-17	Homo sapiens	143-147
2450551-0	1987	Pyroglutamyl-aprotinin, a new aprotinin homologue from bovine lungs--isolation, properties, sequence analysis and characterization using 1H nuclear magnetic resonance in solution.	Hydrogen	137-139	pancreatic trypsin inhibitor	Bos taurus	13-22
12203045-0	2002	Mutation analysis of the sodium/hydrogen exchanger gene (NHE5) in familial paroxysmal kinesigenic dyskinesia.	Hydrogen	32-40	solute carrier family 9 member A5	Homo sapiens	57-61
3663595-2	1987	The denaturation of human and bovine antithrombin III by guanidine hydrochloride has been followed by 1H NMR spectroscopy.	Hydrogen	102-104	serpin family C member 1	Homo sapiens	37-53
12665309-12	2002	In polar organic solvents such as acetonitrile, the transient absorption spectrum and the quenching rate constant of hydrogen abstraction for triplet 4-ABP are practically the same as those obtained for 4-MBP in aqueous solutions.	Hydrogen	117-125	amine oxidase copper containing 1	Homo sapiens	152-155
2436742-1	1987	Fundic argyrophil carcinoid tumors developed in the course of a 5-year continuous treatment with high dosages of H2-antagonists in a well-documented case of Zollinger-Ellison syndrome with primary hyperparathyroidism, high basal acid output, and serum gastrin.	Hydrogen	113-115	gastrin	Homo sapiens	252-259
12665309-12	2002	In polar organic solvents such as acetonitrile, the transient absorption spectrum and the quenching rate constant of hydrogen abstraction for triplet 4-ABP are practically the same as those obtained for 4-MBP in aqueous solutions.	Hydrogen	117-125	myelin basic protein	Homo sapiens	205-208
12173934-7	2002	In this paper, the backbone motions of the ligand-binding core of GluR2 bound to glutamate were studied using (15)N longitudinal (T1) and transverse (T2) relaxation measurements as well as [1H]-15N nuclear Overhauser effects at 500 and 600 MHz.	Hydrogen	190-192	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	66-71
2957284-3	1987	The latter attacks the deoxyribose, especially at thymidylate residues, by abstracting a hydrogen atom from C-5" to generate a carbon-centered radical on the DNA.	Hydrogen	89-97	complement C5	Homo sapiens	108-111
11539665-3	1986	A 10- to 20-bar carbon dioxide atmosphere, such as may have existed during the first several hundred million years of the earth"s history, would have had a surface temperature of approximately 85 degrees to 110 degrees C.  The early stratosphere should have been dry, thereby precluding the possibility of an oxygenic prebiotic atmosphere caused by photodissociation of water vapor followed by escape of hydrogen to space.	Hydrogen	404-412	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	0-4
12096913-1	2002	The conformational transitions of a small oncogene product, p13(MTCP1), have been studied by high-pressure fluorescence of the intrinsic tryptophan emission and high-pressure 1D and 2D 1H-15N NMR.	Hydrogen	185-187	mature T cell proliferation 1	Homo sapiens	64-69
3491986-1	1986	Steroid 21-hydroxylase [21-OHase; steroid 21-monooxygenase; steroid, hydrogen-donor:oxygen oxidoreductase (21-hydroxylating); EC 1.14.99.10] is a cytochrome P-450 enzyme required for the adrenal synthesis of mineralocorticoids and glucocorticoids.	Hydrogen	69-77	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	0-22
3491986-1	1986	Steroid 21-hydroxylase [21-OHase; steroid 21-monooxygenase; steroid, hydrogen-donor:oxygen oxidoreductase (21-hydroxylating); EC 1.14.99.10] is a cytochrome P-450 enzyme required for the adrenal synthesis of mineralocorticoids and glucocorticoids.	Hydrogen	69-77	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	24-32
3019766-4	1986	Measurements of 1H NMR line broadening observed with partially oxidised samples of native cytochrome c show that ATP and the redox inert multivalent anion Co(CN)3-6 catalyse electron self-exchange.	Hydrogen	16-18	cytochrome c, somatic	Equus caballus	90-102
12222659-3	2002	rCBF was monitored by H2 clearance method with a tissue blood-flow meter.	Hydrogen	22-24	CCAAT/enhancer binding protein zeta	Rattus norvegicus	0-4
3017328-4	1986	Interpretation of these results in the light of X-ray data suggests that ubiquitin contains two independently folded domains that are held together in part by a hydrogen bond between Met-1 and Lys-63 and which can be separated when this bond is broken.	Hydrogen	161-169	granzyme M	Homo sapiens	183-188
12162851-6	2002	In addition, quantitative structure-activity relationships (QSARs) for coumarin 7-hydroxylation in wild-type and mutant CYP2A5 show the importance of amino acid residue properties for substrate binding, whereas QSARs for CYP2A6 substrates indicate the importance of hydrogen bonding and lipophilicity for favourable interactions with the enzyme.	Hydrogen	266-274	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	120-126
3732272-2	1986	Enzyme activity was measured by using 1H spin-echo NMR to measure non-invasively the velocity of hydrogen label exchange between the C-2 positions of two methyl-labelled lactate species.	Hydrogen	38-40	complement C2	Homo sapiens	133-136
3732272-2	1986	Enzyme activity was measured by using 1H spin-echo NMR to measure non-invasively the velocity of hydrogen label exchange between the C-2 positions of two methyl-labelled lactate species.	Hydrogen	97-105	complement C2	Homo sapiens	133-136
11937337-1	2002	Pyridine and benzene bioisosteres of amiloride were synthesized and evaluated for their inhibitory potency against the sodium-hydrogen exchanger (NHE) involved in intracellular pH regulation.	Hydrogen	126-134	solute carrier family 9 member C1	Homo sapiens	146-149
3711077-3	1986	The present study investigates the question whether the pro-S hydrogen at C-4" of PMP is labilized by its active site environment independently of the formation of the ketimine intermediate, i.e. in the absence of substrate.	Hydrogen	62-70	complement 4	Gallus gallus	74-77
11960458-0	2002	Self-complementarity of oligo-2-aminopyridines: a new class of hydrogen-bonded ladders.	Hydrogen	63-71	oligodendrocyte transcription factor 2	Homo sapiens	24-31
3520133-3	1986	Postprandial breath H2 concentrations were mildly increased when these alpha-glucosidase inhibitors were given and no patient complained of any adverse effects (such as flatulence, abdominal pain or diarrhea).	Hydrogen	20-22	sucrase-isomaltase	Homo sapiens	71-88
3008819-0	1986	Two-dimensional 1H NMR studies of cytochrome c: assignment of the N-terminal helix.	Hydrogen	16-18	cytochrome c, somatic	Equus caballus	34-46
3008820-0	1986	Two-dimensional 1H NMR studies of cytochrome c: hydrogen exchange in the N-terminal helix.	Hydrogen	16-18	cytochrome c, somatic	Equus caballus	34-46
3008820-0	1986	Two-dimensional 1H NMR studies of cytochrome c: hydrogen exchange in the N-terminal helix.	Hydrogen	48-56	cytochrome c, somatic	Equus caballus	34-46
34823773-4	2022	However, the proposed structure of acetylated HEC (HECA) was confirmed according to the structural spectra analyses FTIR-ATR, 1H, 13C, and APT-NMR.	Hydrogen	126-128	hdc homolog, cell cycle regulator	Homo sapiens	51-55
34741650-0	2022	Electrochemical biosensing platform based on hydrogen bonding for detection of the SARS-CoV-2 spike antibody.	Hydrogen	45-53	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	94-99
3008820-1	1986	The hydrogen exchange behavior of the N-terminal helical segment in horse heart cytochrome c was studied in both the reduced and the oxidized forms by use of two-dimensional nuclear magnetic resonance methods.	Hydrogen	4-12	cytochrome c, somatic	Equus caballus	80-92
11960474-1	2002	Ga2 reacts spontaneously with H2 in solid Ar matrixes at 12 K to form the cyclic molecule Ga(mu-H)2Ga.	Hydrogen	30-32	electron transfer flavoprotein subunit alpha	Homo sapiens	0-3
12044076-10	2002	In the middle layer, mostly H2-producing acetogens from the delta-Proteobacteria (i.e., Desulfovibrio spp.	Hydrogen	28-30	histocompatibility minor 13	Homo sapiens	102-105
3754548-4	1986	Since a 18OH group was introduced at C-3 on a hydrolytic cleavage of C-2, C-3 epoxy group with alkaline H2(18)O, the original epoxy oxygen should be retained at C-2.	Hydrogen	104-106	complement C2	Homo sapiens	69-77
3754548-4	1986	Since a 18OH group was introduced at C-3 on a hydrolytic cleavage of C-2, C-3 epoxy group with alkaline H2(18)O, the original epoxy oxygen should be retained at C-2.	Hydrogen	104-106	complement C2	Homo sapiens	69-72
3699983-0	1986	Conformational studies on gastrin related peptides by high resolution 1H-n.m.r.	Hydrogen	70-72	gastrin	Homo sapiens	26-33
34755651-4	2021	We herein examine the molecular interactions of different polymers with mucin from bovine submaxillary glands at pH 6.6 by using 1H NMR (Nuclear Magnetic Resonance) that provides atomically resolved information on conformational mobility of the mucin.	Hydrogen	129-131	mucin 1, cell surface associated	Bos taurus	72-77
34755651-4	2021	We herein examine the molecular interactions of different polymers with mucin from bovine submaxillary glands at pH 6.6 by using 1H NMR (Nuclear Magnetic Resonance) that provides atomically resolved information on conformational mobility of the mucin.	Hydrogen	129-131	mucin 1, cell surface associated	Bos taurus	245-250
34960779-5	2021	In silico data show that the Q675H mutation gives rise to a hydrogen-bonds network in the spike polar region.	Hydrogen	60-68	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	90-95
11772017-3	2002	nNOS was found to abstract the pro-R (A-side) hydrogen from NADPH.	Hydrogen	46-54	nitric oxide synthase 1	Homo sapiens	0-4
34956606-3	2022	For instance, upon the initial attachment, the receptor binding domain of the S protein forms primarily hydrogen bonds with the protease domain of ACE2 resulting in conformational changes within the secondary structure.	Hydrogen	104-112	angiotensin converting enzyme 2	Homo sapiens	147-151
34174648-7	2021	Besides, the encapsulation changed the crystalline state of curcumin to amorphous, and the pH-driven mechanism was probably related to hydrogen bonding, hydrophobic and electrostatic interactions.	Hydrogen	135-143	phenylalanine hydroxylase	Homo sapiens	91-93
34687759-2	2021	FTIR and 1H NMR spectra confirmed the derivatization of CS, the enhanced swelling behavior was long-established while XRD measurement stated the semicrystalline nature of the VACS derivative.	Hydrogen	9-11	citrate synthase	Homo sapiens	56-58
34687759-3	2021	In a further step, blends between CS and VACS were prepared in ratios CS/VACS 90/10 up to 10/90 w/w and the formation of hydrogen bonds was noticed through FTIR and XRD measurements.	Hydrogen	121-129	citrate synthase	Homo sapiens	34-36
34880650-1	2021	Plasma membrane sodium-hydrogen exchangers (NHE) transport Na+ into cells in exchange for H+.	Hydrogen	23-31	solute carrier family 9 member C1	Homo sapiens	44-47
33327806-8	2021	The oxindole ring is accommodated in the hinge region interacting through hydrogen bonding with the backbone CO and NH of the key amino acids Glu81 and Leu83, respectively, in CDK2 and Asp133 and Val135, respectively, in GSK-3beta.	Hydrogen	74-82	cyclin dependent kinase 2	Homo sapiens	176-180
33327806-8	2021	The oxindole ring is accommodated in the hinge region interacting through hydrogen bonding with the backbone CO and NH of the key amino acids Glu81 and Leu83, respectively, in CDK2 and Asp133 and Val135, respectively, in GSK-3beta.	Hydrogen	74-82	glycogen synthase kinase 3 alpha	Homo sapiens	221-230
34229824-5	2021	MTO-1 revealed an overpotential () = 1.329 V and Tafel slope (b) = 374 mV/dec towards Oxygen Evolution Reaction (OER) electrocatalyst and exhibited = 0.914 V and b = 301.4 mV/dec towards Hydrogen Evolution Reaction (HER) electrocatalyst, both in presence of alkaline 1 M KOH solution, making these MgTiO3 nanoparticles very promising for potential use in various technologically important electrochemical applications.	Hydrogen	187-195	mitochondrial tRNA translation optimization 1	Homo sapiens	0-5
34562851-8	2021	The tighter binding interface and the new hydrogen bonds formation also contribute to the improved binding affinity of RBD to the receptor hACE2.	Hydrogen	42-50	angiotensin converting enzyme 2	Homo sapiens	139-144
4015102-0	1985	Hydrogen-tritium exchange by apoferritin and ferritin.	Hydrogen	0-8	ferritin heavy chain 1	Homo sapiens	29-40
3885857-8	1985	This may suggest that the formation of the insulin dimer is not driven by hydrophobic bonding but, rather, is driven by the formation between subunits of four hydrogen bonds in an apolar environment.	Hydrogen	159-167	insulin	Bos taurus	43-50
3158880-3	1985	Drug activation and the consequent hydrogen abstraction reaction, presumably generating a carbon-centered radical at C-5", do not require molecular oxygen but have a dose-dependent relation with thiol.	Hydrogen	35-43	complement C5	Homo sapiens	117-120
2983759-2	1985	These distances have been used in conjunction with other constraints and a distance algorithm procedure to demonstrate that the structure of the peptide-metal complex as shown by 1H NMR is consistent with the structure of the EF calcium binding loop in the X-ray structure of parvalbumin but that the available 1H NMR distances do not uniquely define the solution structure.	Hydrogen	179-181	parvalbumin alpha	Oryctolagus cuniculus	276-287
2983759-2	1985	These distances have been used in conjunction with other constraints and a distance algorithm procedure to demonstrate that the structure of the peptide-metal complex as shown by 1H NMR is consistent with the structure of the EF calcium binding loop in the X-ray structure of parvalbumin but that the available 1H NMR distances do not uniquely define the solution structure.	Hydrogen	311-313	parvalbumin alpha	Oryctolagus cuniculus	276-287
6497388-10	1984	The similarity of the amino acid composition of EF-1 gamma and EF-1 delta and the molar ratio of alpha: beta: gamma: delta in EF-1H of approximately 1:1:0.5:0.5 have led to the conclusion that EF-1 delta is probably a breakdown product of EF-1 gamma, and that the native form of EF-1H probably contains only the alpha, beta, and gamma subunits.	Hydrogen	282-284	elongation factor 1-delta	Oryctolagus cuniculus	193-203
6498165-2	1984	Met, deoxy, and CO forms of myoglobin (Mb) react with a stoichiometric amount of cyanogen bromide (BrCN) to cause substantial changes in the 1H NMR, optical absorption, and infrared spectra.	Hydrogen	141-143	myoglobin	Homo sapiens	28-37
6465896-4	1984	However, during the early stages of thermolysin digestion of HCS(hPL), both difference and second-order absorption spectra do indicate the transient presence of a similar hydrogen-bonded Trp-carboxylate complex.	Hydrogen	171-179	galectin 1	Homo sapiens	65-68
6699007-5	1984	NADPH complex was determined with 1H and 13C NMR spectroscopy and homonuclear decoupling and was shown to have Hg covalently attached to C-5 of the nicotinamide ring.	Hydrogen	34-36	complement C5	Homo sapiens	137-140
6358204-3	1983	It is a substrate for the NADPH-dependent thioredoxin reductase of rabbit bone marrow, catalyzes the reduction of insulin disulfides by dithiothreitol, and is a hydrogen donor for methionine sulfoxide reductase of yeast.	Hydrogen	161-169	thioredoxin	Homo sapiens	42-53
6358204-7	1983	These observations suggest that instead of serving as a hydrogen donor for ribonucleotide reduction in bone marrow, this thioredoxin may be involved in the regulation of the activity of bone marrow enzyme(s).	Hydrogen	56-64	thioredoxin	Homo sapiens	121-132
6409155-1	1983	The binding of Cd2+ by molecules in the intracellular region of human erythrocytes has been studied by 1H-NMR spectroscopy.	Hydrogen	103-105	CD2 molecule	Homo sapiens	15-18
6409155-3	1983	Time-courses were measured by 1H-NMR for the uptake of Cd2+ by intact erythrocytes in saline/glucose solution and in whole blood.	Hydrogen	30-32	CD2 molecule	Homo sapiens	55-58
6863249-2	1983	For both complexes, the orientation allowing optimal hydrogen bonding involves interaction between negatively charged residues on cytochrome b5 and positively charged residues on methemoglobin.	Hydrogen	53-61	cytochrome b5 type A	Homo sapiens	130-143
6863249-5	1983	A fourth hydrogen bond involves alpha-61 (Lys) bridging between a heme propionate from cytochrome b5 and a heme propionate from the alpha-chain.	Hydrogen	9-17	cytochrome b5 type A	Homo sapiens	87-100
6863249-6	1983	The contacts present in the beta-chain X cytochrome b5 complex involve hydrogen-bonding between beta-chain lysyl residues 59, 61, 65, and 95, and cytochrome b5 residues 48 (Glu), 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Hydrogen	71-79	cytochrome b5 type A	Homo sapiens	41-54
6863249-7	1983	An additional hydrogen bond can be formed by bridging of the epsilon-amino group of beta-66 (Lys) between a heme propionate from cytochrome b5 and a beta-chain heme propionate.	Hydrogen	14-22	cytochrome b5 type A	Homo sapiens	129-142
6420717-6	1983	We conclude that the increase in hydrogen ion generation rate during BDH indicates that the patients increased their intake of fixed acid.	Hydrogen	33-41	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	69-72
6217836-3	1982	At pH 7.0 and 61 degrees C, the incorporation of 18O from solvent H2(18)O onto the C-1 carbon atom of the diastereomeric alpha- and beta-pyranose sugars was followed by 13C NMR spectroscopy in a continuous assay mode.	Hydrogen	66-68	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	83-86
7099981-3	1982	In the present study, secretin and motilin were obtained in 16% and 10% yields, respectively, after simplified two-step purification of hydrogen fluoride-cleaved peptides by gel filtration followed by preparation high performance liquid chromatography.	Hydrogen	136-144	SCT	Canis lupus familiaris	22-30
7079574-0	1982	Effect of hydrogen ions on influx and efflux of Ba2+ and Cd2+ in adrenal medulla.	Hydrogen	10-18	CD2 molecule	Homo sapiens	57-60
7326032-1	1981	Loss of C-5 hydrogen during conversion of D-glucuronate to L-iduronate.	Hydrogen	12-20	complement C5	Homo sapiens	8-11
7272338-0	1981	Structure determination of two oligomannoside-type glycopeptides obtained from bovine lactotransferrin, by 500 MHz 1H-NMR spectroscopy.	Hydrogen	115-117	lactotransferrin	Bos taurus	86-102
6260137-5	1981	Fourfold acceleration of base-catalyzed exchange was observed for Tyr2 NH; it is proposed that this is the result of electronic effects induced by hydrogen bonding of Cys1 C=0, either to Cys6 NH or to the N-terminal amino group.	Hydrogen	147-155	cystin 1	Homo sapiens	167-171
20309030-5	1980	Irradiation of LiF with 1.8 x 10(13)p/cm(2) at 85 MeV changed the transmittance of the hydrogen Lyman-alpha line at 121.6 nm from 55 to 23%.	Hydrogen	87-95	LIF interleukin 6 family cytokine	Homo sapiens	15-18
6106214-12	1980	This method has also been used to measure isotope exchange (1H-2H) of lactate and of pyruvate at both the C-3 and the C-2 positions, and some of these exchange rates can be interpreted in terms of the activity of specific enzymes in the cells.	Hydrogen	60-62	complement C2	Homo sapiens	118-121
7353039-0	1980	Structural study of the heme crevice in cytochrome b5 based on individual assignments of the 1H-NMR lines of the heme group and selected amino acid residues.	Hydrogen	93-95	cytochrome b5 type A	Homo sapiens	40-53
41713-1	1979	The study by means of 1H nuclear magnetic resonance (NMR) of the histidines of phospholipase A2 isolated from porcine, bovine and equine pancreas is reported.	Hydrogen	22-24	LOC104974671	Bos taurus	79-95
377293-1	1979	Purified calf thymus ribonucleoside-diphosphate reductase (2"-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2"-oxidoreductase, EC 1.17.4.1), showed an absolute requirement for a dithiol as hydrogen donor, whereas the natural monothiol glutathione (GSH) was inactive per se.	Hydrogen	196-204	thioredoxin	Homo sapiens	103-114
498062-4	1979	The distinctive bay geometry, with a methyl group opposite to a hydrogen, H(12), peri to another hydrogen, H(11), has a long bond C(13)--C(18) = 1.47(1)A in the bay, and the angular benz-ring is inclined at 16.5 degrees to the mean plane of the anthracene fragment.	Hydrogen	64-72	H1.2 linker histone, cluster member	Homo sapiens	74-79
11795822-1	2002	Counterpropagation neural networks were applied to the fast prediction of 1H NMR chemical shifts of CHn groups in organic compounds.	Hydrogen	74-76	chimerin 1	Homo sapiens	100-103
498062-4	1979	The distinctive bay geometry, with a methyl group opposite to a hydrogen, H(12), peri to another hydrogen, H(11), has a long bond C(13)--C(18) = 1.47(1)A in the bay, and the angular benz-ring is inclined at 16.5 degrees to the mean plane of the anthracene fragment.	Hydrogen	97-105	H1.2 linker histone, cluster member	Homo sapiens	74-79
352341-0	1978	The proton exchange of the pro-S hydrogen atom at C-1 in dihydroxyacetone phosphate and D-fructose 1,6-bisphosphate catalysed by class-I and class-II aldolases.	Hydrogen	33-41	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	50-53
34331351-0	2021	Protein structure prediction using deep learning distance and hydrogen-bonding restraints in CASP14.	Hydrogen	62-70	caspase 14	Homo sapiens	93-99
11834591-6	2002	In the HS group, a small decrease in EAAT1-immunoreactivity (IR) was observed in CA4 and in the polymorphic and supragranular layer of the dentate gyrus, compared with the control group.	Hydrogen	7-9	carbonic anhydrase 4	Homo sapiens	81-84
344312-7	1978	Hydrogen at C-7 of DAHP was not lost in the cyclization step of the reaction, indicating that the enol formed in phosphate elimination participated directly in an aldolase-type reaction with the carbonyl at C-2.	Hydrogen	0-8	complement C2	Homo sapiens	207-210
34087713-5	2021	However, HCS-GA conjugate showed the highest antioxidant activity, due to the higher GA conjugation degrees and decreased intramolecular hydrogen bonds and crystallinity in HCS-GA conjugate.	Hydrogen	137-145	holocarboxylase synthetase	Homo sapiens	9-12
11885987-0	2002	Complete 1H, 15N and 13C assignments of the carboxyl terminal domain of the ciliary neurotrophic factor receptor (CNTFR).	Hydrogen	9-11	ciliary neurotrophic factor receptor	Homo sapiens	76-112
34087713-5	2021	However, HCS-GA conjugate showed the highest antioxidant activity, due to the higher GA conjugation degrees and decreased intramolecular hydrogen bonds and crystallinity in HCS-GA conjugate.	Hydrogen	137-145	holocarboxylase synthetase	Homo sapiens	173-176
34617524-5	2021	This perspective presents selected examples illustrating the significance of hydrogen bonds offered by the coordination and the organometallic complexes that aid in providing the desired orientation to a substrate adjacent to a catalytic metal center and remarkably assisting in the catalysis.	Hydrogen	77-85	activation induced cytidine deaminase	Homo sapiens	158-161
204006-1	1978	The conformation of [Leu5]enkephalin is produced by a Tyr-Gly-Gly-Phe beta bend stabilized by antiparallel hydrogen bonding between tyrosine and phenylalanine.	Hydrogen	107-115	tripartite motif containing 13	Homo sapiens	21-25
12200855-7	2002	Finally, the Western blotting results verified that the levels of protein expression of CDK2, cyclin A and cyclin E were relatively high in alpha 1H transfectants compared to control cultures.	Hydrogen	146-148	cyclin dependent kinase 2	Homo sapiens	88-92
302395-3	1977	The transfer of hydrogen to the cofactor involves homolysis of the carbon-cobalt bond to generate cob(II) alamin and the 5"-deoxyadenos-5"-yl radical, followed by abstraction of a hydrogen atom from the substrate to form 5"-deoxyadenosine and the substrate radical.	Hydrogen	16-24	metabolism of cobalamin associated B	Homo sapiens	74-77
302395-3	1977	The transfer of hydrogen to the cofactor involves homolysis of the carbon-cobalt bond to generate cob(II) alamin and the 5"-deoxyadenos-5"-yl radical, followed by abstraction of a hydrogen atom from the substrate to form 5"-deoxyadenosine and the substrate radical.	Hydrogen	180-188	metabolism of cobalamin associated B	Homo sapiens	74-77
34891497-10	2021	FTIR spectra indicated characteristic absorption peaks related to the chemical structure of PVA, fibroin and Ag NPs, it demonstrated good interactions between them, caused by strong intermolecular hydrogen bonds.	Hydrogen	197-205	fibroin light chain	Bombyx mori	97-104
34655895-6	2021	Additional salt bridges, hydrogen bonds, and a high number of non-bonded contacts (i.e., non-bonded interactions between atoms in the same molecule and those in other molecules) were observed only in the mutant complexes, allowing efficient binding to the ACE2 receptor.	Hydrogen	25-33	angiotensin converting enzyme 2	Homo sapiens	256-260
11735518-3	2001	Whereas xanthobilirubic acid (which is a model for one-half of bilirubin, the yellow pigment of jaundice) and its homologues with hexanoic and longer acid chains at C-8 engage only in intermolecular hydrogen bonding, 1 is found to engage in intramolecular hydrogen bonding.	Hydrogen	199-207	homeobox C8	Homo sapiens	165-168
34612290-5	2021	The simulations show that the spike tries to maximize the contacts with stratum corneum lipids, particularly ceramides, with substantial hydrogen bonding.	Hydrogen	137-145	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	30-35
836046-0	1977	An intramolecular C-2 leads to C-1 hydrogen transfer during the acid-catalyzed conversion of D-xylose to D-threo-pentulose (D-xylulose).	Hydrogen	35-43	complement C2	Homo sapiens	18-21
836046-0	1977	An intramolecular C-2 leads to C-1 hydrogen transfer during the acid-catalyzed conversion of D-xylose to D-threo-pentulose (D-xylulose).	Hydrogen	35-43	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	31-34
1000057-2	1976	The effect of substituting a hydrogen atom of C-4 for a CH3 radical and that of replacing the carbonyl function with a cyanomethylenic substituent is also reported.	Hydrogen	29-37	complement C4A (Rodgers blood group)	Homo sapiens	46-49
34554733-5	2021	The us-HEA/C achieves an ultrahigh mass activity of 28.3 A mg-1noble metals at -0.05 V (vs the reversible hydrogen electrode, RHE) for HER in 0.5 M H2SO4 solution, which is 40.4 and 74.5 times higher than those of the commercial Pt/C and Rh/C catalysts, respectively.	Hydrogen	106-114	factor interacting with PAPOLA and CPSF1	Homo sapiens	126-129
5127-0	1976	Contact-shifted resonances in the 1H NMR spectra of cytochrome b5.	Hydrogen	34-36	cytochrome b5 type A	Homo sapiens	52-65
11735518-3	2001	Whereas xanthobilirubic acid (which is a model for one-half of bilirubin, the yellow pigment of jaundice) and its homologues with hexanoic and longer acid chains at C-8 engage only in intermolecular hydrogen bonding, 1 is found to engage in intramolecular hydrogen bonding.	Hydrogen	256-264	homeobox C8	Homo sapiens	165-168
5127-2	1976	This paper describes the identification of some of the contact-shifted resonances in the 1H NMR spectrum of low spin ferric cytochrome b5.	Hydrogen	89-91	cytochrome b5 type A	Homo sapiens	124-137
5127-7	1976	The experiments described in this paper further revealed the coexistence in aqueous solutions of two different molecular species of cytochrome b5, which can be simultaneously observed in the regions of the 1H NMR spectrum which contain the largely contact-shifted resonances.	Hydrogen	206-208	cytochrome b5 type A	Homo sapiens	132-145
5132-4	1976	The difference in the strength of such hydrogen bonding between peroxidase and myoglobin was discussed.	Hydrogen	39-47	myoglobin	Homo sapiens	79-88
11722471-1	2001	Defects of both sodium-hydrogen exchange (NHE) and sodium-lithium countertransport (SLC) have been described in subjects at increased risk of coronary heart disease (CHD).	Hydrogen	23-31	solute carrier family 9 member C1	Homo sapiens	42-45
1279-0	1976	Hydrogen-isotope exchange of oxidized and reduced cytochrome c.	Hydrogen	0-8	cytochrome c, somatic	Equus caballus	50-62
34663815-5	2021	Hydrogen-deuterium exchange reveals multiple calcineurin-PI4KA complex contacts, including a calcineurin-binding peptide motif in the disordered tail of FAM126A, which we establish as a calcineurin substrate.	Hydrogen	0-8	phosphatidylinositol 4-kinase alpha	Homo sapiens	57-62
34723603-0	2021	Hydrogen Bonding Sequence Directed Coil-Globule Transition in Water Soluble Thermoresponsive Polymers.	Hydrogen	0-8	coilin	Homo sapiens	35-39
11580280-3	2001	Crystal structures of mutants of human MnSOD in which Trp161 was replaced with Ala or Phe showed significant conformational changes on adjacent residues near the active site, particularly Gln143 and Tyr34 which in wild-type MnSOD participate in a hydrogen bond network believed to support proton transfer during catalysis.	Hydrogen	247-255	superoxide dismutase 2	Homo sapiens	39-44
34723603-2	2021	Using polypropylene oxide as an example we demonstrate by means of atomistic molecular dynamics simulations that temperature-induced increase in the sequence length of monomers that are not hydrogen bonded to water drives the coil-globule transition.	Hydrogen	190-198	coilin	Homo sapiens	226-230
34868643-5	2021	Compound II bears a carb-oxy-lic group, which favors a strong hydrogen bond.	Hydrogen	62-70	syntaxin 8	Homo sapiens	20-24
1279-2	1976	Hydrogen-deuterium exchange in 2H20 solutions of the two redox states of horse heart cytochrome c was investigated at 20 degrees C, pH 7, by mass spectrometry and infrared spectroscopy.	Hydrogen	0-8	cytochrome c, somatic	Equus caballus	85-97
1220664-6	1975	The estimation of heritabilities in half and full sibs revealed with h2 = 60% high henetic influences on the elastin content of the aorta and equally so on the ash percentage of elastic fibers.	Hydrogen	69-71	LOC100620140	Sus scrofa	109-116
11580280-3	2001	Crystal structures of mutants of human MnSOD in which Trp161 was replaced with Ala or Phe showed significant conformational changes on adjacent residues near the active site, particularly Gln143 and Tyr34 which in wild-type MnSOD participate in a hydrogen bond network believed to support proton transfer during catalysis.	Hydrogen	247-255	superoxide dismutase 2	Homo sapiens	224-229
11477109-11	2001	Ser-530 makes six contacts with EPA and four with LA involving C-8 through C-16; these interactions influence the alignment of the substrate for hydrogen abstraction.	Hydrogen	145-153	homeobox C8	Homo sapiens	63-66
50084-3	1975	The results of the above methods, coupled with the observed vicinal alpha-CH-NH coupling constants and chemical shifts, indicate that in trifluoroethanol the peptide NH PROTONS OF D-Phe4, D-Phe9, L-Orn2, and L-Val6 are exposed to the sovent, and those of L-Val1, L-Orn7, and L-Leu8 are solvent shielded and intramolecularly hydrogen bonded.	Hydrogen	324-332	selectin L	Homo sapiens	277-281
34477762-5	2021	The supramolecular structure of the Co-bpe MOF was stabilized through strong hydrogen bonding.	Hydrogen	77-85	lysine acetyltransferase 8	Homo sapiens	43-46
34417717-0	2021	1H, 15N, and 13C resonance assignments of the SH3-like tandem domain of human KIN protein.	Hydrogen	0-2	Kin17 DNA and RNA binding protein	Homo sapiens	78-81
34417717-4	2021	Herein, we present the 1H, 15N, and 13C resonances assignment of the backbone and side chains for the SH3-like tandem domain of the hKIN protein, as well as the secondary structure prediction based on the assigned chemical shifts using TALOS-N software.	Hydrogen	23-25	Kin17 DNA and RNA binding protein	Homo sapiens	132-136
11727984-0	2001	1H, 13C and 15N chemical shift assignment of the honeybee odorant-binding protein ASP2.	Hydrogen	0-2	odorant binding protein 2	Apis mellifera	82-86
34214560-7	2021	The obtained results demonstrated the synthesized SnO-NiO anode material could be promising electrode for urea-rich containing wastewater remediation and hydrogen production from wastewater.	Hydrogen	154-162	strawberry notch homolog 1	Homo sapiens	50-53
1140194-6	1975	The deuterium excess of hydrogens derived from NADPH (at C-3 and C-5) was approximately the same as that of hydrogen derived directly from water (at C-4).	Hydrogen	24-33	complement C5	Rattus norvegicus	65-68
1140194-6	1975	The deuterium excess of hydrogens derived from NADPH (at C-3 and C-5) was approximately the same as that of hydrogen derived directly from water (at C-4).	Hydrogen	24-32	complement C5	Rattus norvegicus	65-68
11906576-3	2001	Pre-incubation of the feed with lactase resulted in breath hydrogen levels and total crying time which were both at least 45% lower than figures with placebo treatment, in 26% of the full trial group (95% confidence interval 12.9% to 44.4%), and in 38% of compliers (95% confidence interval 18.8% to 59.4%).	Hydrogen	59-67	lactase	Homo sapiens	32-39
238344-3	1975	Proximal RTA is characterized by the loss of bicarbonate, distal RTA by a defect to establish a hydrogen ion gradient and thus to accomplish acidification of urine.	Hydrogen	96-104	MAS related GPR family member F	Homo sapiens	9-12
238344-3	1975	Proximal RTA is characterized by the loss of bicarbonate, distal RTA by a defect to establish a hydrogen ion gradient and thus to accomplish acidification of urine.	Hydrogen	96-104	MAS related GPR family member F	Homo sapiens	65-68
4154895-2	1974	Kinetic studies and hydrogen transfer between C-17 of estradiol-17 beta and C-20 or progesterone].	Hydrogen	20-28	cytokine like 1	Homo sapiens	46-50
4733837-0	1973	Hydrogen-deuterium exchange kinetics of the C-2 protons of imidazole and histidine compounds.	Hydrogen	0-8	complement C2	Homo sapiens	44-47
4333849-16	1971	These experiments imply a facilitation of lactate dehydrogenase and glucose 6-phosphatase activities by 1h after birth, and a stimulation of phosphoenolpyruvate carboxykinase and glucose 6-phosphatase steps by 1 day after birth.	Hydrogen	104-106	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	68-89
5275374-3	1970	This reaction can be formulated as an abstraction of hydrogen from the C-21-hydroxyl group to form a C-21-alkoxy radical, followed by a 1,5-H.shift from the C-16 atom and beta-scission of the C-16-alkoxy radical leading to the loss of a C(2) fragment (C-20 and C-21) with the formation of the double bond between C-16 and C-17.	Hydrogen	53-61	cytokine like 1	Homo sapiens	322-326
5780508-2	1969	The stereochemistry of hydrogen elimination at C-2 during aromatization.	Hydrogen	23-31	complement C2	Homo sapiens	47-50
5723331-0	1968	1-H NMR studies on deuterium-hydrogen exchange at C-5 in uridines.	Hydrogen	29-37	complement C5	Homo sapiens	50-53
6077819-0	1967	The participation of the two non-equivalent C-5" hydrogens of B 12-coenzyme in the catalytic process.	Hydrogen	49-58	complement C5	Homo sapiens	44-47
6025563-0	1967	The tritium-hydrogen exchange of myosin and its proteolytic fragments.	Hydrogen	12-20	myosin heavy chain 14	Homo sapiens	33-39
33711702-4	2021	Vanillin could bind to alpha-glucosidase by hydrophobic interactions and hydrogen bonds with -8.42 kcal/mol intermolecular energy to form the steric hindrance.	Hydrogen	73-81	sucrase-isomaltase	Homo sapiens	23-40
33640771-5	2021	The steady-state and transient fluorescence analysis suggested the ZEN could interact with zein to form the complex driven by hydrophobic force and hydrogen bonds, which is in accordance with the molecular modeling studies.	Hydrogen	148-156	zein	Zea mays	91-95
33893666-4	2021	The dynamic nanosheets form adaptive defects/pores in the synthetic process of CoP nanoparticles, giving embedded composite with high hydrogen evolution activity (overpotential of 66 mV at 10 mA cm-2 ) and stability.	Hydrogen	134-142	caspase recruitment domain family member 16	Homo sapiens	79-82
33640502-8	2021	The results of the study on the controlled release mechanism showed that the addition of counter ion formed hydrogen bonds with RVS and PSA respectively, which reduced the fluidity and molecular mobility of PSA, and enhanced the interaction between RVS and PSA, thus achieving the purpose of long-acting effect.	Hydrogen	108-116	aminopeptidase puromycin sensitive	Homo sapiens	136-139
33640502-8	2021	The results of the study on the controlled release mechanism showed that the addition of counter ion formed hydrogen bonds with RVS and PSA respectively, which reduced the fluidity and molecular mobility of PSA, and enhanced the interaction between RVS and PSA, thus achieving the purpose of long-acting effect.	Hydrogen	108-116	aminopeptidase puromycin sensitive	Homo sapiens	207-210
33640502-8	2021	The results of the study on the controlled release mechanism showed that the addition of counter ion formed hydrogen bonds with RVS and PSA respectively, which reduced the fluidity and molecular mobility of PSA, and enhanced the interaction between RVS and PSA, thus achieving the purpose of long-acting effect.	Hydrogen	108-116	aminopeptidase puromycin sensitive	Homo sapiens	207-210
33611046-5	2021	More importantly, the optimized Ru9.8/r-CoP catalyst has the lowest activation energy (45.3 kJ mol-1) and exhibits excellent catalytic performance for NaBH4 hydrolysis with a high hydrogen generation rate 9783.3 mLH2 min-1 gcat-1 at 25  C, which is higher than most of the cobalt-based catalysts.	Hydrogen	180-188	caspase recruitment domain family member 16	Homo sapiens	40-43
33611046-5	2021	More importantly, the optimized Ru9.8/r-CoP catalyst has the lowest activation energy (45.3 kJ mol-1) and exhibits excellent catalytic performance for NaBH4 hydrolysis with a high hydrogen generation rate 9783.3 mLH2 min-1 gcat-1 at 25  C, which is higher than most of the cobalt-based catalysts.	Hydrogen	180-188	LIM homeobox protein 2	Mus musculus	212-216
32396763-5	2021	FT-IR and 1H NMR spectroscopy techniques used to analyze the structural features of the MLV-SA-g-AA-RB.	Hydrogen	10-12	S-antigen visual arrestin	Homo sapiens	92-96
34018392-5	2021	8-Oxo-G is recognized by Gln315 of hOGG1 mainly through hydrogen bonds mediated by continuous exchange of 2 water molecules.	Hydrogen	56-64	8-oxoguanine DNA glycosylase	Homo sapiens	35-40
33997868-10	2021	Our data reveal that electrostatic interactions, hydrogen bonds, and pi-pi interactions synergistically contribute to the binding of fast green FCF to the alpha-synuclein pentamer.	Hydrogen	49-57	synuclein alpha	Homo sapiens	155-170
33729600-3	2021	When HCN/ClCN interacts with H2 C EH2 by two sites, the strength of hydrogen bond/halogen bond is stronger than that of pi-hole bond.	Hydrogen	68-76	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	5-8
33978972-0	2021	Hydrogen Gas Sensors Using Palladium Nanogaps on an Elastomeric Substrate.	Hydrogen	0-8	gastrin	Homo sapiens	9-12
33978972-2	2021	Due to safety issues caused by the highly flammable and explosive character of hydrogen gas (H2 ), it is imperative to develop the sensors that can quickly and sensitively detect H2 leaks.	Hydrogen	79-87	gastrin	Homo sapiens	88-91
33641242-4	2021	The conformational changes of beta2 GPI upon binding with the liposomes were analyzed using hydrogen/deuterium exchange mass spectrometry (HDXMS).	Hydrogen	92-100	apolipoprotein H	Homo sapiens	30-39
34436857-6	2021	As the strength of hydrogen bonding between PVP and solvent increases, the peak position of nuC O(free) shifts toward lower frequencies.	Hydrogen	19-27	nucleobindin 1	Homo sapiens	92-95
34460262-0	2021	Electronic Tuning of SnS2 Nanosheets by Hydrogen Incorporation for Efficient CO2 Electroreduction.	Hydrogen	40-48	sodium voltage-gated channel alpha subunit 11	Homo sapiens	21-25
34460262-2	2021	Herein, we developed a facile hydrogen incorporation strategy for improving the catalytic activities of SnS2 nanosheets toward CO2 electroreduction.	Hydrogen	30-38	sodium voltage-gated channel alpha subunit 11	Homo sapiens	104-108
34460262-3	2021	Compared with SnS2 nanosheets, the hydrogen-incorporated SnS2 (denoted as H-SnS2) nanosheets exhibited high current density and Faradaic efficiency (FE) for formate.	Hydrogen	35-43	sodium voltage-gated channel alpha subunit 11	Homo sapiens	57-61
34460262-3	2021	Compared with SnS2 nanosheets, the hydrogen-incorporated SnS2 (denoted as H-SnS2) nanosheets exhibited high current density and Faradaic efficiency (FE) for formate.	Hydrogen	35-43	sodium voltage-gated channel alpha subunit 11	Homo sapiens	74-80
34460262-5	2021	Mechanistic studies disclosed that the incorporation of surface hydrogen induced the electron injection into the structures of H-SnS2 nanosheets, which largely facilitates the process of CO2 activation.	Hydrogen	64-72	sodium voltage-gated channel alpha subunit 11	Homo sapiens	127-133
34460262-6	2021	Density functional theory (DFT) calculations further revealed that hydrogen incorporation decreased the energy barrier for the formation of HCOO* intermediates, thus contributing to the CO2-to-formate conversion on H-SnS2 nanosheets.	Hydrogen	67-75	sodium voltage-gated channel alpha subunit 11	Homo sapiens	215-221
34575142-7	2021	A total of 21 amino acid residues of DBLbeta12 interact with 26 amino acid residues in the gC1qR trimer through 99 nonbonding interactions and 4 hydrogen bonds.	Hydrogen	145-153	complement C1q binding protein	Homo sapiens	91-96
34553103-6	2021	A binding site at the terminus of an oligomer detects local information about changes in pH or anion concentration and transmits that information-in the form of a directionality switch in the hydrogen-bond chain-to a remote polarity-sensitive fluorophore.	Hydrogen	192-200	phenylalanine hydroxylase	Homo sapiens	89-91
34333227-9	2021	The adsorption of SWCNTs on the B domain surface led to a significant change in solvent-accessible surface, internal hydrogen bonds, and finally in the tertiary structure, which could provide a reasonable method to impede the interaction between the angiotensin-converting enzyme II and SARS-CoV-2 spike glycoprotein.	Hydrogen	117-125	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	298-303
34351742-5	2021	A molecular docking study showed the disruption of the interaction of compound 1 via hydrogen interactions with Arg403, Asp405, and Arg408 of SARS-CoV-2 RBD and Arg393 and His34 residues of ACE2.	Hydrogen	85-93	angiotensin converting enzyme 2	Homo sapiens	190-194
34723270-0	2021	Cation- and pH-Dependent Hydrogen Evolution and Oxidation Reaction Kinetics.	Hydrogen	25-33	phenylalanine hydroxylase	Homo sapiens	12-14
34723270-2	2021	In this work, a series of structure-making/breaking cations in the electrolyte were investigated as spectator cations in hydrogen evolution and oxidation reactions (HER/HOR) in the pH range of 1 to 14, whose kinetics was found to be altered by up to 2 orders of magnitude by these cations.	Hydrogen	121-129	phenylalanine hydroxylase	Homo sapiens	181-183
34443663-8	2021	By analyzing the hydrogen bonds, we found the residues G605 and K529 in Mps1 formed stable hydrogen bonds with compounds, it was more conducive to activities of Mps1 inhibitors.	Hydrogen	17-25	TTK protein kinase	Homo sapiens	72-76
34443663-8	2021	By analyzing the hydrogen bonds, we found the residues G605 and K529 in Mps1 formed stable hydrogen bonds with compounds, it was more conducive to activities of Mps1 inhibitors.	Hydrogen	17-25	TTK protein kinase	Homo sapiens	161-165
34443663-8	2021	By analyzing the hydrogen bonds, we found the residues G605 and K529 in Mps1 formed stable hydrogen bonds with compounds, it was more conducive to activities of Mps1 inhibitors.	Hydrogen	91-99	TTK protein kinase	Homo sapiens	72-76
34443663-8	2021	By analyzing the hydrogen bonds, we found the residues G605 and K529 in Mps1 formed stable hydrogen bonds with compounds, it was more conducive to activities of Mps1 inhibitors.	Hydrogen	91-99	TTK protein kinase	Homo sapiens	161-165
34340307-2	2021	This H-ZIS/b-TiO2 flower-like heterojunction hollow spheres with a narrow band gap of ~1.88 eV expand the light response to visible light and show excellent photocatalytic hydrogen evolution rate (278 mumol h-1 50 mg-1) under visible-light irradiation, which is 1.5 times as high as that of ZnIn2S4/black TiO2 heterojunction hollow spheres (ZIS/b-TiO2) (181 mumol h-1 50 mg-1).	Hydrogen	172-180	zinc finger RANBP2-type containing 2	Homo sapiens	341-344
34443739-4	2021	This study demonstrates that the stronger hydrogen bonding interactions existed in PFD-BTO/PVDF composite film comparative to the PDA-BTO/PVDF composite film induced the higher beta-phase formation (90%), which was evidenced by the XRD, FTIR and DSC results, as well as led to a better dispersion of NPs and improved mechanical properties of composite films.	Hydrogen	42-50	desmocollin 3	Homo sapiens	246-249
34471491-6	2021	Such an unwinding exposes one of the A...A mismatches (that interacts with Tyr245) at the major groove side and also facilitates the on and off hydrogen bonding interaction with Lys546 sidechain (MSH2-domain-IV).	Hydrogen	144-152	mutS homolog 2	Homo sapiens	196-200
34336792-0	2021	In Situ Generated Novel 1H MRI Reporter for beta-Galactosidase Activity Detection and Visualization in Living Tumor Cells.	Hydrogen	24-26	galactosidase beta 1	Homo sapiens	44-62
34335249-4	2021	Using the microscale thermophoresis technology, we confirmed that the Leu68 site was the essential hydrogen bond site of NW binding to CSE.	Hydrogen	99-107	cystathionine gamma-lyase	Rattus norvegicus	135-138
34160205-0	2021	Mesoporous Bimetallic Au@Rh Core-Shell Nanowires as Efficient Electrocatalysts for pH-Universal Hydrogen Evolution.	Hydrogen	96-104	phenylalanine hydroxylase	Homo sapiens	83-85
34160205-1	2021	Electrochemical water splitting is one hopeful strategy for hydrogen production, and designing efficient hydrogen evolution electrocatalysts under universal pH is one of the most critical topics.	Hydrogen	60-68	phenylalanine hydroxylase	Homo sapiens	157-159
34160205-1	2021	Electrochemical water splitting is one hopeful strategy for hydrogen production, and designing efficient hydrogen evolution electrocatalysts under universal pH is one of the most critical topics.	Hydrogen	105-113	phenylalanine hydroxylase	Homo sapiens	157-159
34160205-3	2021	Due to the one-dimensional structure and mesoporous core-shell structure, Au@mRh NWs possess more active sites and provide the synergistic effect, leading to the great improvement of the electrochemical activity toward the hydrogen evolution reaction under a wide range of pH.	Hydrogen	223-231	phenylalanine hydroxylase	Homo sapiens	273-275
34133148-0	2021	Tandem Photocatalysis Protocol for Hydrogen Generation/Olefin Hydrogenation Using Pd-g-C3N4-Imine/TiO2 Nanoparticles.	Hydrogen	35-43	phosphoglycerate dehydrogenase	Homo sapiens	82-86
34226543-5	2021	Under the intense synergy among the Mo-S bond, internal electric field and S-vacancies, the optimized photocatalyst exhibits high hydrogen evolution rate of 63.21 mmol g-1 h-1 with an apparent quantum yield of 76.48% at 420 nm monochromatic light, which is about 18.8-fold of the pristine ZIS.	Hydrogen	130-138	zinc finger RANBP2-type containing 2	Homo sapiens	289-292
34386323-9	2021	G201, K220, K230, A321, and D335 in kinase domain of GRK2 might form hydrogen bonds with CP-25.	Hydrogen	69-77	G protein-coupled receptor kinase 2	Rattus norvegicus	53-57
34116056-0	2021	An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids.	Hydrogen	15-23	CREB regulated transcription coactivator 1	Mus musculus	65-71
34145512-4	2021	Moreover, the pi-pi interaction and hydrogen bond between the PEL and Pd-WO3/g-C3N4 composite improved the charge-transfer properties.	Hydrogen	36-44	phosphoglycerate dehydrogenase	Homo sapiens	70-78
35504076-6	2022	The umami structures in the six core umami peptides with the lowest binding energy were easy to connect with Ser, Glu, His, Gln, Arg and Lys residues in T1R3 through hydrogen bond and salt bridge.	Hydrogen	166-174	taste 1 receptor member 3	Homo sapiens	153-157
35337497-4	2022	FTIR and thermal analysis showed that the thermal stability was also improved due to the formation of hydrogen bonds between THY/HPbetaCD inclusion complexes and CS/PCL nanofibers.	Hydrogen	102-110	citrate synthase	Homo sapiens	162-164
35613322-4	2022	The hydrogel was composed of a regular hierarchical porous structure, which was built by the hydrogen bonding between TA and CS.	Hydrogen	93-101	citrate synthase	Homo sapiens	125-127
35093677-4	2022	In this review, we give an introduction to SCP production by heterotrophic microbial species, phototrophs, methanotrophs and autotrophic hydrogen oxidizers, as well as highlight some challenges and the latest developments in the growing SCP industry.	Hydrogen	137-145	solute carrier family 50 member 1	Homo sapiens	43-46
35626976-5	2022	Molecular docking indicated that the above four oat-derived peptides were predicted to form hydrogen bonds, attractive charge, and hydrophobic interactions with the residues of the active site of DPP-IV.	Hydrogen	92-100	ornithine aminotransferase	Homo sapiens	48-51
35601543-6	2022	Energy-minimized conformation of APA-peptides reveals the possibility of intermolecular hydrogen bonding.	Hydrogen	88-96	glutamyl aminopeptidase	Homo sapiens	33-36
35503765-1	2022	Sodium-hydrogen exchangers (NHEs) tightly regulate intracellular pH (pHi), proliferation, migration and cell volume.	Hydrogen	7-15	glucose-6-phosphate isomerase	Homo sapiens	69-72
35496913-6	2022	Previously, we found that SC family member, the sodium-hydrogen exchanger NHE6, was expressed in all wildtype cochlear tissues, and that Nhe6-knockout mice displayed moderate hearing loss.	Hydrogen	55-63	solute carrier family 9 (sodium/hydrogen exchanger), member 6	Mus musculus	74-78
35496913-6	2022	Previously, we found that SC family member, the sodium-hydrogen exchanger NHE6, was expressed in all wildtype cochlear tissues, and that Nhe6-knockout mice displayed moderate hearing loss.	Hydrogen	55-63	solute carrier family 9 (sodium/hydrogen exchanger), member 6	Mus musculus	137-141
35089587-6	2022	X-ray crystallographic structure determination and binding measurements using isothermal titration calorimetry demonstrated that hydrophobic interactions in which Leu158 of HPV16 E6 plays a key role and a network of intermolecular hydrogen bonds sustain the complex formation between PTPN4 PDZ and the PBM of HPV16 E6.	Hydrogen	231-239	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	284-289
35408690-6	2022	It was suggested that the esters of DBP play a pivotal role in the inhibition of Hs GSK-3beta through the formation of hydrogen bonds with Arg96/Glu97 amino acid residues in pocket 2.	Hydrogen	119-127	glycogen synthase kinase 3 alpha	Homo sapiens	84-93
35319386-10	2022	At 24 h, the serum UCH-L1 and NSE levels were increased in the hydrogen and control groups (P<0.05), but not in the sham group.	Hydrogen	63-71	ubiquitin carboxyl-terminal hydrolase isozyme L1	Oryctolagus cuniculus	19-25
35319386-11	2022	At 48 and 72 h post-CA, the plasma UCH-L1 and NSE levels in the hydrogen and control groups gradually decreased.	Hydrogen	64-72	ubiquitin carboxyl-terminal hydrolase isozyme L1	Oryctolagus cuniculus	35-41
35328828-7	2022	More specifically, strong electrostatic interactions (salt bridges) and hydrogen bonding were observed between R493 and R498 residues of the Omicron RBD with D30/E35 and D38 residues of the hACE2, respectively.	Hydrogen	72-80	angiotensin converting enzyme 2	Homo sapiens	190-195
35328828-8	2022	Other mutated amino acids in the Omicron RBD, e.g., S496 and H505, also exhibited hydrogen bonding with the hACE2 receptor.	Hydrogen	82-90	angiotensin converting enzyme 2	Homo sapiens	108-113
35260173-5	2022	The contact of QDs with PTM (prothrombin), PLG (plasminogen) and FIB (fibrinogen) which are primary coagulation-related proteins in the coagulation and fibrinolysis systems formed QDs-protein conjugates through hydrogen-bonding and hydrophobic interaction.	Hydrogen	211-219	plasminogen	Homo sapiens	43-46
35260173-5	2022	The contact of QDs with PTM (prothrombin), PLG (plasminogen) and FIB (fibrinogen) which are primary coagulation-related proteins in the coagulation and fibrinolysis systems formed QDs-protein conjugates through hydrogen-bonding and hydrophobic interaction.	Hydrogen	211-219	plasminogen	Homo sapiens	48-59
35243596-6	2022	The deletions of amino acids Asp119 and Phe120 in ORF8 of delta variant resulted in structural instability of ORF8 dimer caused by disruption of hydrogen bonds and salt bridges as revealed by structural analysis and MD simulation studies.	Hydrogen	145-153	ORF8 protein	Severe acute respiratory syndrome coronavirus 2	50-54
35243596-6	2022	The deletions of amino acids Asp119 and Phe120 in ORF8 of delta variant resulted in structural instability of ORF8 dimer caused by disruption of hydrogen bonds and salt bridges as revealed by structural analysis and MD simulation studies.	Hydrogen	145-153	ORF8 protein	Severe acute respiratory syndrome coronavirus 2	110-114
35098651-0	2022	Insights into Antiperovskite Ni3 In1-x Cux N Multi-Crystalline Nanoplates and Bulk Cubic Particles as Efficient Electrocatalysts on Hydrogen Evolution Reaction.	Hydrogen	132-140	cut like homeobox 1	Homo sapiens	39-42
35197056-6	2022	RESULTS: 1H MRS reliably quantified changes in cerebral metabolites, including glutamate/glutamine, lactate, and N-acetyl aspartate in a neuronal Pank1 and Pank2 double-knockout (SynCre+ Pank1,2 dKO) mouse model of brain CoA deficiency.	Hydrogen	9-11	pantothenate kinase 1	Mus musculus	146-151
35197056-6	2022	RESULTS: 1H MRS reliably quantified changes in cerebral metabolites, including glutamate/glutamine, lactate, and N-acetyl aspartate in a neuronal Pank1 and Pank2 double-knockout (SynCre+ Pank1,2 dKO) mouse model of brain CoA deficiency.	Hydrogen	9-11	pantothenate kinase 1	Mus musculus	187-192
35209124-6	2022	At a low glycerol content (<12%), DSC revealed that the glass transition temperature and thermally induced crystallization temperature decreased as the glycerol content increased, implying that glycerol mainly interacts with silk proteins through hydrogen bonding.	Hydrogen	247-255	desmocollin 3	Homo sapiens	34-37
35215181-6	2022	Three independent 100 ns molecular dynamics (MD) simulations were performed using NAMD to investigate the hydrogen bonds between S proteins RBD and hACE2 RBD.	Hydrogen	106-114	angiotensin converting enzyme 2	Homo sapiens	148-153
35215181-7	2022	From MD simulations, we found that SARS-CoV-2 forms 19 pairs (average of three simulations) of hydrogen bonds with high occupancy (>50%) to hACE2, compared to 16 pairs between SARS-CoV and hACE2.	Hydrogen	95-103	angiotensin converting enzyme 2	Homo sapiens	140-145
35215181-7	2022	From MD simulations, we found that SARS-CoV-2 forms 19 pairs (average of three simulations) of hydrogen bonds with high occupancy (>50%) to hACE2, compared to 16 pairs between SARS-CoV and hACE2.	Hydrogen	95-103	angiotensin converting enzyme 2	Homo sapiens	189-194
35216095-7	2022	Molecular docking showed that TNGQ and MANT interact with monomeric IAPP mainly by hydrogen bonding and electrostatic interaction, with TNGQ binding at IAPP surface compared to YMSV, which had the highest docking score, but interact mainly through hydrophobic interaction in IAPP core.	Hydrogen	83-91	islet amyloid polypeptide	Homo sapiens	68-72
35140265-7	2022	Computational structural modelling of aloin A and B interaction with PLpro revealed that, both aloin isoforms form hydrogen bond with Tyr268 of PLpro, which is critical for their proteolytic activity.	Hydrogen	115-123	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	69-74
35140265-7	2022	Computational structural modelling of aloin A and B interaction with PLpro revealed that, both aloin isoforms form hydrogen bond with Tyr268 of PLpro, which is critical for their proteolytic activity.	Hydrogen	115-123	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	144-149
35127768-9	2021	Among 9 compounds with the highest frequency of occurrence in the 9 prescriptions, baicalein had the highest ACE2 binding affinity and can be well-combined into the active pocket of ACE2 It is stabilized by forming hydrogen bonds with ASN290 and ILE291 in ACE2 and hydrophobic interaction with PHE438, ILE291, and PRO415.	Hydrogen	215-223	angiotensin converting enzyme 2	Homo sapiens	182-186
35163047-0	2022	Probing the Dynamics of Streptococcus pyogenes Cas9 Endonuclease Bound to the sgRNA Complex Using Hydrogen-Deuterium Exchange Mass Spectrometry.	Hydrogen	98-106	type II CRISPR RNA-guided endonuclease Cas9	Streptococcus pyogenes	47-51
35163047-4	2022	Here, we present the first attempt to describe the solution structure of Cas9 from S. pyogenes using hydrogen-deuterium exchange mass spectrometry (HDX-MS) coupled to molecular dynamics simulations.	Hydrogen	101-109	type II CRISPR RNA-guided endonuclease Cas9	Streptococcus pyogenes	73-77
34969844-5	2022	Rather, the DPS-catalyzed cyclization likely proceeds by hydrogen atom abstraction from C7", oxidation of the benzylic radical to a carbocation, Friedel-Crafts-like ring closure, and rearomatization of ring B by C6 deprotonation.	Hydrogen	57-65	decaprenyl diphosphate synthase subunit 1	Homo sapiens	12-15
34980728-3	2022	After two allergen proteins (alphaS1-casein and beta-casein) extracted from baked sugar cookies were tryptic digested, the obtained phosphorylated peptides were selectively derivatized by beta-elimination with Ba(NO3)2 under basic condition and Michael addition with perfluoroalkylthiol (1H,1H,2H,2H-perfluorooctanethiol, PFOT).	Hydrogen	288-290	casein alpha s1	Homo sapiens	29-43
34980728-3	2022	After two allergen proteins (alphaS1-casein and beta-casein) extracted from baked sugar cookies were tryptic digested, the obtained phosphorylated peptides were selectively derivatized by beta-elimination with Ba(NO3)2 under basic condition and Michael addition with perfluoroalkylthiol (1H,1H,2H,2H-perfluorooctanethiol, PFOT).	Hydrogen	291-293	casein alpha s1	Homo sapiens	29-43
35005149-4	2022	The data supplied in this work are related to the research article entitled "Dynamics and Conformational Changes in Human NEIL2 DNA Glycosylase Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry".	Hydrogen	156-164	nei like DNA glycosylase 2	Homo sapiens	122-127
33450449-6	2021	The difference of their inhibitory mechanism may be closely related to the different types of inhibition, the different strength of their interaction with tyrosinase and the different number of hydrogen bonds between them.	Hydrogen	194-202	tyrosinase	Mus musculus	155-165
33995901-0	2021	Combination of multiple computational methods revealing specific sub-sectional recognition and hydrogen-bond dependent transportation of CKII peptide fragment in O-GlcNAc transferase.	Hydrogen	95-103	casein kinase 2 alpha 1	Homo sapiens	137-141
33995901-10	2021	The whole process is strong exothermic that is highly dependent on the variation of hydrogen bond interactions between peptide and OGT as well as the performance of different subsections of peptide.	Hydrogen	84-92	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	131-134
33544928-1	2021	The analysis of crystal structures of SF 5 - or SF 4 -containing molecules revealed that these groups are often surrounded by hydrogen or other fluorine atoms.	Hydrogen	126-134	SURP and G-patch domain containing 1	Homo sapiens	38-52
33733600-6	2021	Experimental characterizations and DFT calculations demonstrate that the strong electronic interaction at the heterointerface of CoNiP/CoP is achieved via the electron transfer from CoNiP to the heterointerface, which directly promotes the dissociation of water at heterointerface and desorption of hydrogen on CoNiP.	Hydrogen	299-307	caspase recruitment domain family member 16	Homo sapiens	135-138
33876086-6	2021	The H41, M49, and C145 residues have highest priority with respect to interactions with small molecules through hydrogen bond, CH-pi, and van der Waals interactions.	Hydrogen	112-120	CDV3 homolog	Homo sapiens	4-7
33550185-5	2021	Molecular docking revealed that V6 can form hydrogen bonds with vimentin at 273R and 276Y in its rod domain.	Hydrogen	44-52	vimentin	Homo sapiens	64-72
33620224-4	2021	alpha-Synuclein variants were predicted to be disordered, as in the experiments, but the A53T mutant showed less predicted disorder, in contrast with the wide-line 1H NMR result.	Hydrogen	164-166	synuclein alpha	Homo sapiens	0-15
33595272-0	2021	NiCo-Layered Double Hydroxide-Derived B-Doped CoP/Ni2P Hollow Nanoprisms as High-Efficiency Electrocatalysts for Hydrogen Evolution Reaction.	Hydrogen	113-121	caspase recruitment domain family member 16	Homo sapiens	46-49
33648410-3	2021	The pharmacophore model for FFAR-1 (r2 = 0.98, q2 = 0.90) and PPAR-G (r2 = 0.89, q2 = 0.88) suggested that one hydrogen bond acceptor, one hydrogen bond donor, three aromatic rings, and two hydrophobic groups arranged in 3D space are essential for the binding affinity of FFAR-1 and PPAR-G inhibitors.	Hydrogen	111-119	free fatty acid receptor 1	Homo sapiens	28-34
33648410-3	2021	The pharmacophore model for FFAR-1 (r2 = 0.98, q2 = 0.90) and PPAR-G (r2 = 0.89, q2 = 0.88) suggested that one hydrogen bond acceptor, one hydrogen bond donor, three aromatic rings, and two hydrophobic groups arranged in 3D space are essential for the binding affinity of FFAR-1 and PPAR-G inhibitors.	Hydrogen	111-119	free fatty acid receptor 1	Homo sapiens	272-278
33648410-3	2021	The pharmacophore model for FFAR-1 (r2 = 0.98, q2 = 0.90) and PPAR-G (r2 = 0.89, q2 = 0.88) suggested that one hydrogen bond acceptor, one hydrogen bond donor, three aromatic rings, and two hydrophobic groups arranged in 3D space are essential for the binding affinity of FFAR-1 and PPAR-G inhibitors.	Hydrogen	139-147	free fatty acid receptor 1	Homo sapiens	28-34
33648410-3	2021	The pharmacophore model for FFAR-1 (r2 = 0.98, q2 = 0.90) and PPAR-G (r2 = 0.89, q2 = 0.88) suggested that one hydrogen bond acceptor, one hydrogen bond donor, three aromatic rings, and two hydrophobic groups arranged in 3D space are essential for the binding affinity of FFAR-1 and PPAR-G inhibitors.	Hydrogen	139-147	free fatty acid receptor 1	Homo sapiens	272-278
32697740-4	2021	Its binding to the GLO-I active site seemed to be mainly driven by ionic interaction via its ionized hydroxyl groups with the central Zn ion and Lys156, along with other numerous hydrogen bonding and hydrophobic interactions.	Hydrogen	179-187	glyoxalase I	Homo sapiens	19-24
33604973-2	2021	The hydrogen fluxes reach 3.76 mmol h-1 cm-2 in a Zn//Zn symmetric cell in each segment, and 7.70 mmol h-1 cm-2 in a Zn//MnO2 full cell.	Hydrogen	4-12	H1.5 linker histone, cluster member	Homo sapiens	36-44
33604973-4	2021	Precisely quantitated, the Zn@ZnF2 //Zn@ZnF2 cell only produces 0.02 mmol h-1 cm-2 of hydrogen (0.53% of the Zn//Zn cell).	Hydrogen	86-94	H1.5 linker histone, cluster member	Homo sapiens	74-82
33604973-5	2021	Encouragingly, a high-areal-capacity Zn@ZnF2 //MnO2 ( 3.2 mAh cm-2 ) full cell only produces maximum hydrogen flux of 0.06 mmol h-1 cm-2 (0.78% of the Zn//Zn cell) at the fully charging state.	Hydrogen	101-109	H1.5 linker histone, cluster member	Homo sapiens	128-136
33111209-1	2021	BACKGROUND: Hydrogen/potassium ATPase beta (ATP4B) is a proton pump acting an essential role in gastric acid secretion.	Hydrogen	12-20	ATPase H+/K+ transporting subunit beta	Homo sapiens	44-49
33739886-8	2021	The possible PCB interaction with Sox4 transcriptional protein was confirmed through molecular docking where three hydrogen bonds were formed at ARG and LYS residues at a stable binding energy of -4.72.	Hydrogen	115-123	SRY (sex determining region Y)-box 4	Mus musculus	34-38
33649367-0	2021	Gas chromatography techniques to evaluate the hydrogen permeation characteristics in rubber: ethylene propylene diene monomer.	Hydrogen	46-54	gastrin	Homo sapiens	0-3
33649367-1	2021	We established an ex-situ technique for evaluating hydrogen gas permeability by thermal desorption analysis (TDA) gas chromatography (GC) and by self-developed diffusion analysis software.	Hydrogen	51-59	gastrin	Homo sapiens	60-63
33649367-1	2021	We established an ex-situ technique for evaluating hydrogen gas permeability by thermal desorption analysis (TDA) gas chromatography (GC) and by self-developed diffusion analysis software.	Hydrogen	51-59	gastrin	Homo sapiens	114-117
33624196-7	2021	MEP value and binding energy of HCN and CN- complexes all increase after replacing one or two hydrogen atoms by halogen atoms (F, Cl, Br) in Lewis acid.	Hydrogen	94-102	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	32-35
33347277-6	2021	The effective intermolecular electrostatic interactions could stem from a variety of interactions in different organic RTP crystals, such as hydrogen bonding, pi-halogen bonding, anion-pi+ interaction, and d-ppi bonds and so forth.	Hydrogen	141-149	MORN repeat containing 4	Homo sapiens	119-122
33593208-5	2022	Based on the molecular docking studies, compounds 3 and 5 docked into the active site of the alpha-glucosidase enzyme, forming mainly hydrogen bonds in the active site.	Hydrogen	134-142	sucrase-isomaltase	Homo sapiens	93-110
33069027-1	2021	This work presents solution- and solid-state evidence of the enhancement of J-like aggregation of a cationic polythiophene (CPT) with isothiouronium functionalities (PT1), caused by a decrease in the polarity and hydrogen-bonding (H-bonding) capacity of the solvent, generated by using a 50:50 v/v 1,4-dioxane-water mixture (W-DI) instead of water.	Hydrogen	213-221	zinc finger protein 77	Homo sapiens	166-169
33668509-5	2021	In this study we used high resolution 1H magnetic resonance spectroscopy (1H-MRS) to identify early noninvasive MR (Magnetic Resonance)-detectable metabolic biomarkers of response to mutant IDH inhibition.	Hydrogen	38-40	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	190-193
33668509-5	2021	In this study we used high resolution 1H magnetic resonance spectroscopy (1H-MRS) to identify early noninvasive MR (Magnetic Resonance)-detectable metabolic biomarkers of response to mutant IDH inhibition.	Hydrogen	74-76	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	190-193
33554754-8	2021	Additionally, the S359F and S359I mutations resulted in increased RCL flexibility owing to the disruption of stabilizing hydrogen bonding interaction at the distal end of strand S5A.	Hydrogen	121-129	proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Homo sapiens	178-181
33274824-5	2021	Docking studies showed that compound 2-(4-methoxybenzyl)-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl thiocyanate binds within the active sites of transforming growth factor beta (TGF- beta) type I receptor kinase domain by strong hydrogen binding and hydrophobic interactions.	Hydrogen	248-256	transforming growth factor beta receptor 1	Homo sapiens	197-223
32909754-7	2021	Selected complexes were evaluated as photosensitizers for hydrogen production, with the kappa2N-NMe2 complex resulting in a stable and efficient photocatalytic system reaching TONRe values of over 2100, representing the first application of the 3ILCT state of a rhenium(I) carbonyl complex in a stable photocatalytic system.	Hydrogen	58-66	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	96-100
31068026-0	2021	Correlations of PPARalpha and PPARgamma expressions with 1H-MRS quantified hepatic fat content in pups of rats that experienced intrauterine growth restriction.	Hydrogen	57-59	peroxisome proliferator activated receptor alpha	Rattus norvegicus	16-25
31068026-2	2021	This study was to explore the association of peroxisome proliferator-activated receptor alpha and gamma (PPARalpha and PPARgamma) expression with 1H-MRS quantified hepatic fat content in offspring of rats that experienced intrauterine growth restriction (IUGR).	Hydrogen	146-148	peroxisome proliferator activated receptor alpha	Rattus norvegicus	45-93
31068026-2	2021	This study was to explore the association of peroxisome proliferator-activated receptor alpha and gamma (PPARalpha and PPARgamma) expression with 1H-MRS quantified hepatic fat content in offspring of rats that experienced intrauterine growth restriction (IUGR).	Hydrogen	146-148	peroxisome proliferator activated receptor alpha	Rattus norvegicus	105-114
32970293-4	2021	The most potent inhibitor was a 1-tetralone derivative (1h) with IC50 values of 0.036 and 0.0011 microM for MAO-A and MAO-B, respectively.	Hydrogen	56-58	monoamine oxidase A	Homo sapiens	108-113
33512059-1	2021	A new family of transition-metal monosilicides (MSi, M = Ti, Mn, Fe, Ru, Ni, Pd, Co, and Rh) electrocatalysts with superior electrocatalytic performance of hydrogen evolution is reported, based on the computational and experimental results.	Hydrogen	156-164	RB binding protein 4, chromatin remodeling factor	Homo sapiens	48-51
33512059-3	2021	The previously reported RuSi is not only fabricated more readily but eventually explored 8 MSi that can be good hydrogen evolution reaction catalysts.	Hydrogen	112-120	RB binding protein 4, chromatin remodeling factor	Homo sapiens	91-94
33448281-0	2021	Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3.	Hydrogen	11-19	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	72-81
33572941-2	2021	IDUA catalyzes the degradation of the glycosaminoglycans dermatan and heparan sulfate (DS and HS, respectively).	Hydrogen	94-96	alpha-L-iduronidase	Homo sapiens	0-4
33449065-0	2021	First-principles investigation of the hydrogen evolution reaction of transition metal phosphides CrP, MnP, FeP, CoP, and NiP.	Hydrogen	38-46	caspase recruitment domain family member 16	Homo sapiens	112-115
33503880-5	2021	In per-residue energy decomposition analysis, four residues, K362, R376, Y436, and K439 in hcGAS were found to contribute significantly to the binding with inhibitors via hydrogen bonding, salt bridges, and various pi interactions, such as pi     pi stacking, cation     pi, hydroxyl     pi, and alkyl     pi interactions.	Hydrogen	171-179	cyclic GMP-AMP synthase	Homo sapiens	91-96
33469055-8	2021	The 3-D structural model showed that CD155 A67T created a new hydrogen bond and structural change on CD155.	Hydrogen	62-70	PVR cell adhesion molecule	Homo sapiens	37-42
33469055-8	2021	The 3-D structural model showed that CD155 A67T created a new hydrogen bond and structural change on CD155.	Hydrogen	62-70	PVR cell adhesion molecule	Homo sapiens	101-106
33469055-9	2021	These changes resulted in extending the distance and losing the hydrogen bonds between CD155 and CD226, thus weakening CD155/CD226 binding activity.	Hydrogen	64-72	PVR cell adhesion molecule	Homo sapiens	87-92
33469055-9	2021	These changes resulted in extending the distance and losing the hydrogen bonds between CD155 and CD226, thus weakening CD155/CD226 binding activity.	Hydrogen	64-72	PVR cell adhesion molecule	Homo sapiens	119-124
33510842-0	2021	Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.	Hydrogen	0-8	gastrin	Homo sapiens	9-12
33510842-4	2021	In addition, the lightest and diffusible gas molecule hydrogen (H2) has been shown to improve erectile dysfunction (ED), testis injuries, sperm motility in male, preserve ovarian function, protect against uterine inflammation, preeclampsia, and breast cancer in female.	Hydrogen	54-62	gastrin	Homo sapiens	41-44
33385956-6	2021	Molecular modeling studies of 22d docked inside the Sph binding pocket of both SphK1 and SphK2 indicate essential hydrogen bond between the 2-(hydroxymethyl)pyrrolidine head to interact with aspartic acid and serine residues near the ATP binding pocket, which provide the basis for dual inhibition.	Hydrogen	114-122	sphingosine kinase 1	Homo sapiens	79-84
33350995-2	2021	CP 1 and CP 2 display new two-dimensional double-layered honeycomb frameworks containing uncoordinated nitrogen atoms from pyridine and tetrazole rings, which can easily form hydrogen bonds with various analytes.	Hydrogen	175-183	ceruloplasmin	Homo sapiens	9-13
33322895-1	2021	The photocatalytic reduction of water to form hydrogen gas (H2) is a promising approach to collect, convert, and store solar energy.	Hydrogen	46-54	gastrin	Homo sapiens	55-58
33039677-6	2021	The 100 ns molecular dynamics simulation revealed that M1 and M2 formed hydrogen bond to residue Leu387 and Glu353, respectively, on ERalpha ligand binding domain, leading to a reduced binding free energy.	Hydrogen	72-80	estrogen receptor 1	Rattus norvegicus	133-140
32219872-11	2021	Hence, administration of exogenous H2 S in the form of the H2 S donor GYY4137 may be of therapeutic benefit in the context of concurrent hyperlipidemia and hyperglycemia-induced or CCl4 -stimulated liver dysfunction.	Hydrogen	35-37	C-C motif chemokine ligand 4	Homo sapiens	181-185
32219872-11	2021	Hence, administration of exogenous H2 S in the form of the H2 S donor GYY4137 may be of therapeutic benefit in the context of concurrent hyperlipidemia and hyperglycemia-induced or CCl4 -stimulated liver dysfunction.	Hydrogen	59-61	C-C motif chemokine ligand 4	Homo sapiens	181-185
33473229-3	2021	Here we demonstrate that the structure (Pt1-Ptn)/alpha-MoC, where isolated platinum atoms (Pt1) and subnanometre platinum clusters (Ptn) are stabilized on alpha-molybdenum carbide (alpha-MoC), catalyses the WGS reaction even at 313 kelvin, with a hydrogen-production pathway involving direct carbon monoxide dissociation identified.	Hydrogen	247-255	zinc finger protein 77	Homo sapiens	40-43
33473229-3	2021	Here we demonstrate that the structure (Pt1-Ptn)/alpha-MoC, where isolated platinum atoms (Pt1) and subnanometre platinum clusters (Ptn) are stabilized on alpha-molybdenum carbide (alpha-MoC), catalyses the WGS reaction even at 313 kelvin, with a hydrogen-production pathway involving direct carbon monoxide dissociation identified.	Hydrogen	247-255	zinc finger protein 77	Homo sapiens	91-94
33375731-4	2020	The hydrogen evolution rate of CdS/1T-MoS2/TiO2 reaches 3.15 mmol g-1 h-1, which is approximately 12 and 35 times higher than that of pure CdS and CdS/TiO2 binary heterojunction under the same conditions, respectively.	Hydrogen	4-12	CDP-diacylglycerol synthase 1	Homo sapiens	31-34
33375731-4	2020	The hydrogen evolution rate of CdS/1T-MoS2/TiO2 reaches 3.15 mmol g-1 h-1, which is approximately 12 and 35 times higher than that of pure CdS and CdS/TiO2 binary heterojunction under the same conditions, respectively.	Hydrogen	4-12	CDP-diacylglycerol synthase 1	Homo sapiens	139-142
33375731-6	2020	Our results illustrate that the performance of CdS-based heterojunctions for solar hydrogen evolution can be greatly improved by appropriate materials selection.	Hydrogen	83-91	CDP-diacylglycerol synthase 1	Homo sapiens	47-50
33369565-0	2020	Serum Gastrin Predicts Hydrogen-Producing Small Intestinal Bacterial Overgrowth in Patients With Abdominal Surgery: A Prospective Study.	Hydrogen	23-31	gastrin	Homo sapiens	6-13
33345753-6	2020	The change in total volume and the change of own electrons number of hydrogen atoms in their atomic basins are identified as the descriptors correlating the most with the hDHFR inhibition potency.	Hydrogen	69-77	dihydrofolate reductase	Homo sapiens	171-176
33058920-6	2020	Molecular docking and other studies confirmed that curcumin could bind to and upregulate the expression of TET2 and TET3 with hydrogen bonds and arene-H bonds, suggesting that demethylation of RB1 was attributed to reactivation of the demethylation enzymes TET2 and TET3 after curcumin treatment.	Hydrogen	126-134	tet methylcytosine dioxygenase 2	Mus musculus	107-111
33316963-0	2020	The Effect of Intramolecular Hydrogen Bond Type on the Gas-Phase Deprotonation of ortho-Substituted Benzenesulfonic Acids.	Hydrogen	29-37	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	55-58
33112626-3	2020	We have taken a combined approach of in silico molecular docking and hydrogen deuterium exchange-mass spectrometry (HDX-MS) to characterize the interactions between granulocyte colony-stimulating factor (G-CSF), and some common excipients.	Hydrogen	69-77	colony stimulating factor 3	Homo sapiens	165-202
33112626-3	2020	We have taken a combined approach of in silico molecular docking and hydrogen deuterium exchange-mass spectrometry (HDX-MS) to characterize the interactions between granulocyte colony-stimulating factor (G-CSF), and some common excipients.	Hydrogen	69-77	colony stimulating factor 3	Homo sapiens	204-209
33201700-0	2020	Cryogenic Infrared Action Spectroscopy Fingerprints the Hydrogen Bonding Network in Gas-Phase Coumarin Cations.	Hydrogen	56-64	gastrin	Homo sapiens	84-87
33267704-7	2022	The thermodynamic parameters determined by fluorescence quenching experiment and isothermal titration calorimetry (ITC) suggested that the complex between ifosfamide and alpha2M involves hydrogen bonding and hydrophobic interactions.	Hydrogen	187-195	alpha-2-macroglobulin	Homo sapiens	170-177
33155527-8	2022	On the basis of various MD analysis like RMSD, RMSF, Rg, SASA, Number of hydrogen bonds, Principal component analysis and binding free energy (CDK5-ZINC6261568: -129.50 kJ.mol-1 and CDK5-ZINC14168360: -191.16 kJ.mol-1), we have found that ZINC6261568 and ZINC14168360 can act as a lead compound against the CDK5.	Hydrogen	73-81	cyclin dependent kinase 5	Homo sapiens	143-147
33204390-8	2020	The estimation of enthalpy change ( H) and entropy change ( S) suggested that the RA-hTf complex formation is driven by hydrogen bonding, thereby making this process seemingly specific.	Hydrogen	120-128	coagulation factor III, tissue factor	Homo sapiens	85-88
33150769-4	2020	Hydrogen agronomy focuses mainly on the mechanism of hydrogen gas (H2) biology effects in agriculture, and provides a theoretical foundation for the practice of hydrogen agriculture, a component of the new agriculture.	Hydrogen	0-8	gastrin	Homo sapiens	62-65
33150769-4	2020	Hydrogen agronomy focuses mainly on the mechanism of hydrogen gas (H2) biology effects in agriculture, and provides a theoretical foundation for the practice of hydrogen agriculture, a component of the new agriculture.	Hydrogen	53-61	gastrin	Homo sapiens	62-65
33150769-4	2020	Hydrogen agronomy focuses mainly on the mechanism of hydrogen gas (H2) biology effects in agriculture, and provides a theoretical foundation for the practice of hydrogen agriculture, a component of the new agriculture.	Hydrogen	161-169	gastrin	Homo sapiens	62-65
33054205-7	2020	Its interaction with QR-2 was found to involve hydrogen bond and arene-arene interaction as revealed by molecular docking.	Hydrogen	47-55	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	21-25
33066660-1	2020	To develop a high-performance hydrogen gas sensor, we fabricated a composite film made of carbon nanotubes (CNTs) and palladium nanoparticles.	Hydrogen	30-38	gastrin	Homo sapiens	39-42
33066660-3	2020	The response to hydrogen gas was measured during two seasons (summer and winter) using a vacuum chamber by introducing a hydrogen/argon gas mixture.	Hydrogen	16-24	gastrin	Homo sapiens	25-28
33066660-3	2020	The response to hydrogen gas was measured during two seasons (summer and winter) using a vacuum chamber by introducing a hydrogen/argon gas mixture.	Hydrogen	16-24	gastrin	Homo sapiens	136-139
33066660-3	2020	The response to hydrogen gas was measured during two seasons (summer and winter) using a vacuum chamber by introducing a hydrogen/argon gas mixture.	Hydrogen	121-129	gastrin	Homo sapiens	25-28
32999062-4	2020	Lesion bypass is accomplished using a unique protein-template mechanism in which the templating base is evicted from the DNA helix and the incoming dCTP hydrogen bonds with an arginine side chain of Rev1.	Hydrogen	153-161	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	199-203
32865410-4	2020	The structure-activity relationships identified throughout this campaign demonstrate that greater gamma-selectivity can be achieved by inhibitors that occupy an "alkyl-induced" pocket and possess bicyclic hinge-binding motifs capable of forming more than one hydrogen bond to the hinge region of PI3Kgamma.	Hydrogen	259-267	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	296-305
32502813-2	2020	We investigated the hydrogen bonding of H2S dimer using MP2 and CCSD(T) levels of theory in combination with aug-cc-pV(D,T,Q)Z basis sets.	Hydrogen	20-28	tryptase pseudogene 1	Homo sapiens	56-59
32583165-3	2020	Here were report 1H, 13C, and 15N resonance assignments for the intrinsically disordered BRCA1 fragment 219-504, which contains important interaction sites for the proto-oncogenic transcription factor MYC as well as for p53.	Hydrogen	17-19	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	201-204
32926059-3	2020	The porous, graphitized carbon skeleton can not only disperse CoP QDs, increasing active sites for the hydrogen reduction reaction, but also provide electron transfer channels, promoting electron transfer and increasing conductivity.	Hydrogen	103-111	caspase recruitment domain family member 16	Homo sapiens	62-65
32788727-5	2020	The lack of a ligand-entry pathway suggests that SA binding involves a major conformational remodelling of the SA-binding core of NPR4, which we validated using hydrogen-deuterium-exchange mass spectrometry analysis of the full-length protein and through SA-induced disruption of interactions between NPR1 and NPR4.	Hydrogen	161-169	NPR1-like protein 4	Arabidopsis thaliana	130-134
32866372-0	2020	Elucidating the Mechanistic Origins of Photocatalytic Hydrogen Evolution Mediated by MoS2/CdS Quantum-Dot Heterostructures.	Hydrogen	54-62	CDP-diacylglycerol synthase 1	Homo sapiens	90-93
32866372-4	2020	Here, we map energetic offsets and track the dynamics of electron transfer in MoS2/CdS architectures, prepared by interfacing two-dimensional MoS2 nanosheets with CdS quantum dots (QDs), and correlate the observed charge separation to photocatalytic activity in the hydrogen evolution reaction.	Hydrogen	266-274	CDP-diacylglycerol synthase 1	Homo sapiens	83-86
32972350-11	2021	Many rational binding modes of IN04 to LRRK1 kinase domain were investigated and the most likely binding pose containing multiple hydrogen bonds and a salt bridge was discovered.	Hydrogen	130-138	leucine rich repeat kinase 1	Homo sapiens	39-44
11451959-2	2001	Similar to other dehydrogenases, HAD contains a general acid/base, His(158), which is within hydrogen bond distance of a carboxylate, Glu(170).	Hydrogen	19-27	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	33-36
32968183-6	2020	Although the hydrogen bond change is small, with the average experimental cross hydrogen bond 3hJNC" coupling of two proteins GB3 and TTHA increased by ~ 0.01 Hz by the three osmolytes (160 g/L), its effect on protein function should not be overlooked.	Hydrogen	13-21	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	126-129
32968183-6	2020	Although the hydrogen bond change is small, with the average experimental cross hydrogen bond 3hJNC" coupling of two proteins GB3 and TTHA increased by ~ 0.01 Hz by the three osmolytes (160 g/L), its effect on protein function should not be overlooked.	Hydrogen	80-88	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	126-129
32588927-2	2020	These pseudo-anomeric effects are apparent when electronegative CF 2 groups are placed at the C-2, C-4 and C-6 positions of the cyclohexane ring to render the C-3/5 axial hydrogens electropositive.	Hydrogen	171-180	complement C2	Homo sapiens	94-97
32588927-2	2020	These pseudo-anomeric effects are apparent when electronegative CF 2 groups are placed at the C-2, C-4 and C-6 positions of the cyclohexane ring to render the C-3/5 axial hydrogens electropositive.	Hydrogen	171-180	complement C4A (Rodgers blood group)	Homo sapiens	99-102
32974937-3	2020	The large extracellular domain (EC2) of CD53 protrudes away from the membrane surface and exposes a variable region, which is identified by hydrogen-deuterium exchange as the common interface for CD53 and CD81 to bind partners.	Hydrogen	140-148	transcription factor 15	Homo sapiens	32-35
11524005-1	2001	Most cytosolic glutathione S-transferases (GSTs) exploit a hydrogen bond between an active site Tyr and the bound glutathione (GSH) cofactor to lower the pK(a) of the GSH and generate the nucleophilic thiolate anion, GS(-).	Hydrogen	59-67	glutathione S-transferase alpha 1	Homo sapiens	43-47
32813510-0	2020	Template Construction of Porous CoP/COP2 Microflowers Threaded with Carbon Nanotubes toward High-Efficiency Oxygen Evolution and Hydrogen Evolution Electrocatalysts.	Hydrogen	129-137	caspase recruitment domain family member 16	Homo sapiens	32-35
11575777-7	2001	Structural analysis (e.g., covalent N-H bond lengthening) indicates that the hydrogen bond between H3A and 08 of imidazole and betaine respectively (HB2) is slightly stronger than the bond between H1A and O1A of imidazole and picric acid (HB1), although HB1 is shorter than HB2: (dN...O(HB1)= 2.614(1) A, dN...O(HB2) = 2.684(1) A, dH...O(HB1) = 1.630(1) A, dH...O(HB2)= 1.635(1) A, dN-H(HB1) = 1.046(1) A, dN-H(HB2) = 1.057(1) A).	Hydrogen	77-85	keratin 82	Homo sapiens	149-152
11575777-7	2001	Structural analysis (e.g., covalent N-H bond lengthening) indicates that the hydrogen bond between H3A and 08 of imidazole and betaine respectively (HB2) is slightly stronger than the bond between H1A and O1A of imidazole and picric acid (HB1), although HB1 is shorter than HB2: (dN...O(HB1)= 2.614(1) A, dN...O(HB2) = 2.684(1) A, dH...O(HB1) = 1.630(1) A, dH...O(HB2)= 1.635(1) A, dN-H(HB1) = 1.046(1) A, dN-H(HB2) = 1.057(1) A).	Hydrogen	77-85	keratin 82	Homo sapiens	274-277
32488930-4	2020	Adding muonium (a light isotope of hydrogen) to phosphasilenes reveals that: a) the electron-donor NMe 2 and the bulkiest Tip-substituted phosphasilenes form several muoniated radicals with different rotamer conformations; b) bulky Dur-substituted phosphasilene forms two radicals (Si- and P-centred); and c) Mes-substituted phosphasilene mainly forms one species of radical, at the P centre.	Hydrogen	35-43	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	99-104
11575777-7	2001	Structural analysis (e.g., covalent N-H bond lengthening) indicates that the hydrogen bond between H3A and 08 of imidazole and betaine respectively (HB2) is slightly stronger than the bond between H1A and O1A of imidazole and picric acid (HB1), although HB1 is shorter than HB2: (dN...O(HB1)= 2.614(1) A, dN...O(HB2) = 2.684(1) A, dH...O(HB1) = 1.630(1) A, dH...O(HB2)= 1.635(1) A, dN-H(HB1) = 1.046(1) A, dN-H(HB2) = 1.057(1) A).	Hydrogen	77-85	keratin 82	Homo sapiens	274-277
32899395-6	2020	S29/GO complex formation was induced by 1h sonication and its stability was analyzed by chromatography coupled with spectrophotometry and mass spectrometry.	Hydrogen	40-42	ribosomal protein S29	Homo sapiens	0-3
11575777-7	2001	Structural analysis (e.g., covalent N-H bond lengthening) indicates that the hydrogen bond between H3A and 08 of imidazole and betaine respectively (HB2) is slightly stronger than the bond between H1A and O1A of imidazole and picric acid (HB1), although HB1 is shorter than HB2: (dN...O(HB1)= 2.614(1) A, dN...O(HB2) = 2.684(1) A, dH...O(HB1) = 1.630(1) A, dH...O(HB2)= 1.635(1) A, dN-H(HB1) = 1.046(1) A, dN-H(HB2) = 1.057(1) A).	Hydrogen	77-85	keratin 82	Homo sapiens	274-277
11575777-7	2001	Structural analysis (e.g., covalent N-H bond lengthening) indicates that the hydrogen bond between H3A and 08 of imidazole and betaine respectively (HB2) is slightly stronger than the bond between H1A and O1A of imidazole and picric acid (HB1), although HB1 is shorter than HB2: (dN...O(HB1)= 2.614(1) A, dN...O(HB2) = 2.684(1) A, dH...O(HB1) = 1.630(1) A, dH...O(HB2)= 1.635(1) A, dN-H(HB1) = 1.046(1) A, dN-H(HB2) = 1.057(1) A).	Hydrogen	77-85	keratin 82	Homo sapiens	274-277
11572378-14	2001	These results agree with a binding site model involving more than one carboxylic acid group, providing charge complementarity and hydrogen bond donors for binding of L-PA.	Hydrogen	130-138	lipoprotein(a)	Homo sapiens	166-170
32437627-3	2020	We hypothesized that ET-1 would exhibit a sex-specific response to HS/DOCP treatment in PER1 KO.	Hydrogen	67-69	endothelin 1	Mus musculus	21-25
32760933-4	2020	Furthermore, in the presence of NaOEt, the facile occurrence of the intramolecular cyclization led to the formation of acetamidino-bridged dicobalt complex [Cp*Co(mu-SEt)2(mu-eta1:eta1-NH(CCH3)NH)CoCp*][PF6] (5), which may proceed through the nucleophilic attack of amido from NH3 to coordinated MeCN followed by the hydrogen atom transfer process.	Hydrogen	317-325	secreted phosphoprotein 1	Homo sapiens	175-179
11382774-6	2001	Luciferase assays using natural TGF-beta-responsive reporters also revealed the functional importance of H2 in the Smad3 MH1 domain in direct DNA binding.	Hydrogen	105-107	SMAD family member 3	Homo sapiens	115-120
33195011-2	2020	Here, all-atom molecular dynamics simulations of butyrylcholinesterase with tacrine complex were designed to characterize inhibitor binding modes, strengths, and the hydrogen-bond dependent non-covalent release mechanism.	Hydrogen	166-174	butyrylcholinesterase	Homo sapiens	49-70
32421210-6	2020	Preliminary mechanistic study reveals that hydrogen gas is released during the reaction, and both light and the cobalt catalyst are important for the dehydrogenation step.	Hydrogen	43-51	gastrin	Homo sapiens	52-55
11434773-2	2001	Hydrogen/deuterium (H/D) exchange into amide bonds, quantitated by on-line HPLC and mass spectrometry, has been used to compare the dynamic and conformational properties of human HGPRT alone, the HGPRT-GMP-Mg(2+) complex, the HGPRT-IMP-MgPPi &lt;==&gt; HGPRT-Hx-MgPRPP equilibrating mixture, and the transition-state analogue complex HGPRT-ImmGP-MgPPi.	Hydrogen	0-8	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	179-184
32824015-4	2020	H2 gas with a pressure of up to 100 bar resulted in an overall low but still detectable hydrogen absorption, which did not cause any substantial hydrogen embrittlement in specimens under a constant load of 90% of the specified minimum yield strength (SMYS).	Hydrogen	88-96	gastrin	Homo sapiens	3-6
32824015-5	2020	The amount of hydrogen absorbed under conditions with H2S was approximately one order of magnitude larger than under conditions with H2 gas.	Hydrogen	14-22	gastrin	Homo sapiens	136-139
11434773-2	2001	Hydrogen/deuterium (H/D) exchange into amide bonds, quantitated by on-line HPLC and mass spectrometry, has been used to compare the dynamic and conformational properties of human HGPRT alone, the HGPRT-GMP-Mg(2+) complex, the HGPRT-IMP-MgPPi &lt;==&gt; HGPRT-Hx-MgPRPP equilibrating mixture, and the transition-state analogue complex HGPRT-ImmGP-MgPPi.	Hydrogen	0-8	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	196-201
11358499-7	2001	Sedimentation equilibrium studies of apoC-I at submicellar levels of Hex2Gro-PCho and analysis of the effects of apoC-I on the 1H NMR spectrum of Hex2Gro-PCho indicate micelle induction by apoC-I, and establish the capacity of apoC-I to assemble individual phospholipid molecules.	Hydrogen	127-129	apolipoprotein C1	Homo sapiens	113-119
32944136-3	2020	In the quest for potent ROCK-II inhibitors, a ligand-based pharmacophore containing four essential chemical features, namely two hydrogen bond acceptor (HBA), one hydrogen bond donor (HBD), and one hydrophobe (HY), was developed and rigorously validated.	Hydrogen	129-137	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	24-31
31961068-4	2020	Here, we report the structural characterization of the complex between proC2 and 14-3-3 by hydrogen/deuterium mass spectrometry (HDX-MS) and protein crystallography to determine the molecular basis for 14-3-3-mediated inhibition of C2 activation.	Hydrogen	91-99	caspase 2	Homo sapiens	74-76
11358499-7	2001	Sedimentation equilibrium studies of apoC-I at submicellar levels of Hex2Gro-PCho and analysis of the effects of apoC-I on the 1H NMR spectrum of Hex2Gro-PCho indicate micelle induction by apoC-I, and establish the capacity of apoC-I to assemble individual phospholipid molecules.	Hydrogen	127-129	apolipoprotein C1	Homo sapiens	113-119
11358499-7	2001	Sedimentation equilibrium studies of apoC-I at submicellar levels of Hex2Gro-PCho and analysis of the effects of apoC-I on the 1H NMR spectrum of Hex2Gro-PCho indicate micelle induction by apoC-I, and establish the capacity of apoC-I to assemble individual phospholipid molecules.	Hydrogen	127-129	apolipoprotein C1	Homo sapiens	113-119
11354667-6	2001	The resulting model of the closed form of the ATD of mGluR1 indicates that several interdomain hydrogen bonds and salt bridges may be formed upon domain contraction and that the ligand directly participates to this interdomain network.	Hydrogen	95-103	glutamate metabotropic receptor 1	Homo sapiens	53-59
32627945-0	2020	Hierarchical Nanorods of MoS2 /MoP Heterojunction for Efficient Electrocatalytic Hydrogen Evolution Reaction.	Hydrogen	81-89	opioid receptor mu 1	Homo sapiens	31-34
32627945-2	2020	Here, the delicate design and construction of hierarchical MoS2 /MoP (H-MoS2 /MoP) nanorods for the hydrogen evolution reaction (HER) are demonstrated.	Hydrogen	100-108	opioid receptor mu 1	Homo sapiens	65-68
32627945-2	2020	Here, the delicate design and construction of hierarchical MoS2 /MoP (H-MoS2 /MoP) nanorods for the hydrogen evolution reaction (HER) are demonstrated.	Hydrogen	100-108	opioid receptor mu 1	Homo sapiens	78-81
32760642-4	2020	Its Pd2+ complex could be used as a probe for chemoselective detection of monohydrogensulfide (HS-).	Hydrogen	95-98	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	4-7
11471211-3	2001	The expression of HSP72 mRNA in the myocardium significantly decreased in SUS-H2, as compared with that of CON-H2 rats.	Hydrogen	78-80	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	18-23
32479062-4	2020	Moreover, we discover that H2 gas in hydrogen-chemotherapy can inhibit mitochondrial function, hinder ATP synthesis, and cause the reduction of P-gp efflux pump function, which finally attenuate P-gp protein drug transport capacity in cancer cells.	Hydrogen	37-45	phosphoglycolate phosphatase	Homo sapiens	144-148
32479062-4	2020	Moreover, we discover that H2 gas in hydrogen-chemotherapy can inhibit mitochondrial function, hinder ATP synthesis, and cause the reduction of P-gp efflux pump function, which finally attenuate P-gp protein drug transport capacity in cancer cells.	Hydrogen	37-45	phosphoglycolate phosphatase	Homo sapiens	195-199
11330822-0	2001	Complete sequence-specific 1H, 13C and 15N resonance assignments of the human PTK6 SH2 domain.	Hydrogen	27-29	protein tyrosine kinase 6	Homo sapiens	78-82
32691752-2	2020	The Mn0.45Cu0.05Cd0.5S nanotriangles exhibited a high hydrogen yield of 147 921 mumol g-1 h-1 under visible light irradiation, about 7.4 times higher than that of pristine Mn0.5Cd0.5S.	Hydrogen	54-62	H1.5 linker histone, cluster member	Homo sapiens	90-93
11333014-6	2001	This interaction involves the hydrogen bonding donor or acceptor potential of the hydroxyl group of U33 and has to be integrated in an extended definition of the anticodon hairpin.	Hydrogen	30-38	small nucleolar RNA, C/D box 33	Homo sapiens	100-103
32678237-7	2020	Cells in the TEC exhibit a specific metabolic profile of functional adipocytes identified by 1H-NMR.	Hydrogen	93-95	tec protein tyrosine kinase	Rattus norvegicus	13-16
11333022-3	2001	The results demonstrate that the overall strength of hydrogen bonding between the 5" splice site, SD4, and the free 5" end of the U1 snRNA correlates with env expression efficiency, as long as env expression is suboptimal, and that a continuous stretch of 14 hydrogen bonds can lead to full env expression, as a result of stabilizing the pre-mRNA.	Hydrogen	53-61	RNA, U1 small nuclear 1	Homo sapiens	130-138
11333022-3	2001	The results demonstrate that the overall strength of hydrogen bonding between the 5" splice site, SD4, and the free 5" end of the U1 snRNA correlates with env expression efficiency, as long as env expression is suboptimal, and that a continuous stretch of 14 hydrogen bonds can lead to full env expression, as a result of stabilizing the pre-mRNA.	Hydrogen	259-267	RNA, U1 small nuclear 1	Homo sapiens	130-138
11170644-5	2001	It showed that the hit compound is located in the active site of MIF containing the N-terminal proline which plays an important role in the tautomerase reaction and forms several hydrogen bonds and undergoes hydrophobic interactions.	Hydrogen	179-187	macrophage migration inhibitory factor	Homo sapiens	65-68
32662801-0	2020	MOF-derived hierarchical 3D bi-doped CoP nanoflower eletrocatalyst for hydrogen evolution reaction in both acidic and alkaline media.	Hydrogen	71-79	caspase recruitment domain family member 16	Homo sapiens	37-40
32651409-6	2020	In this study, we synthesized nano-graphene oxide (NGO) nanoparticles with GRPR-specific peptides AF750-6Ahx-Sta-BBN via hydrogen bond and pi-pi bonds (NGO-BBN-AF750), and investigated their receptor binding, cell uptake and internalization in HSC-3 cells.	Hydrogen	121-129	GCY	Homo sapiens	109-112
11254205-0	2001	Short-strong hydrogen bonds and a low barrier transition state for the proton transfer reaction in RNase A catalysis: a quantum chemical study.	Hydrogen	13-21	ribonuclease A family member 1, pancreatic	Homo sapiens	99-106
32844004-4	2020	All forms share the same supra-molecular structure, based on infinite C 1 1(4) chain motifs formed by N-H O inter-molecular hydrogen bonds, as usual for non-sterically hindered amides.	Hydrogen	124-132	PRKR interacting protein 1	Homo sapiens	70-78
31402760-4	2020	Among the desired compounds, 1h shares the highest inhibitory activity (IC50 = 1.34 muM) against PTP-MEG2.	Hydrogen	29-31	protein tyrosine phosphatase non-receptor type 9	Homo sapiens	97-105
31402760-5	2020	Additionally, various post-dynamic analyses confirmed that when compound 1h bound to the PTP-MEG2, the protein conformations became unstable and the function of the pTyr recognition loop (Asn331-Cys338) would be disturbed.	Hydrogen	73-75	protein tyrosine phosphatase non-receptor type 9	Homo sapiens	89-97
11250198-8	2001	Interaction with the degenerate position is mediated by a purine-specific hydrogen bond to N7, ensuring specificity, and water-mediated H bonding to the purine N6/O6 and pyrimidine N4/O4, allowing degeneracy.	Hydrogen	74-82	immunoglobulin kappa variable 1D-37 (non-functional)	Homo sapiens	181-186
32587267-6	2020	The evaluation of enthalpy change ( H) and entropy change ( S) suggested that the MARK4-RA complex formation is driven by hydrogen bonding and thus complexation process is seemingly specific.	Hydrogen	122-130	microtubule affinity regulating kinase 4	Homo sapiens	82-87
11160649-5	2001	Structure activity studies with 30 benzimidazolone derivatives revealed that ethyl and hydrogen groups at the 1 and 3 nitrogen positions, respectively, were critical for the activation of hIK1 K+ channels and that other alkyl groups were not tolerated at these positions without some loss in potency.	Hydrogen	87-95	IKAROS family zinc finger 1	Homo sapiens	188-192
32714406-14	2020	The hydroxyl groups on the 12 sites of the ginsenoside Rh2 glycoside framework are found to have hydrogen bonding with Leu240.	Hydrogen	97-105	Rh associated glycoprotein	Homo sapiens	55-58
32714406-15	2020	The formation of hydrogen bonds plays an important role in binding of ginsenoside Rg3 and ginsenoside Rh2 to EpCAM, as well as the stability of EpCAM conformation.	Hydrogen	17-25	Rh associated glycoprotein	Homo sapiens	102-105
11170358-4	2001	The same methodology applied to steps in the catalytic mechanism of citrate synthase further supports the conclusion that one need not invoke special concepts such as "low-barrier hydrogen bonds" or "pK(a) matching" to explain enzyme catalysis.	Hydrogen	180-188	citrate synthase	Homo sapiens	68-84
32027458-3	2020	X-ray structure elucidation revealed hydrogen-bridged linear [CN(HCN) 2 ] - and Y-shaped [CN(HCN) 3 ] - molecular ions in the crystal.	Hydrogen	37-45	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	65-68
11499444-2	2001	This ESR peak intensity in DAp with collagen (c-DAp) decreased in an increase in the amount of collagen added into Ca(H2PO4)2H2O (MCP) electrolytic solution, because dangling H+ of HPO(4)2- binds to the carboxyl group of collagen due to the hydrogen bond.	Hydrogen	241-249	death associated protein	Homo sapiens	27-30
32637390-3	2020	The tricarbonyl (eta4-cyclopentadienone) iron complex catalyzed dehydrogenative cyclization, releasing water and hydrogen gas as by-products.	Hydrogen	66-74	gastrin	Homo sapiens	122-125
32040807-10	2020	Docking studies suggested that the main interaction between lead molecules and JNK3 enzyme consisted of hydrogen bond interaction with methionine 149 of the hinge region.	Hydrogen	104-112	mitogen-activated protein kinase 10	Homo sapiens	79-83
11499444-2	2001	This ESR peak intensity in DAp with collagen (c-DAp) decreased in an increase in the amount of collagen added into Ca(H2PO4)2H2O (MCP) electrolytic solution, because dangling H+ of HPO(4)2- binds to the carboxyl group of collagen due to the hydrogen bond.	Hydrogen	241-249	cytidine deaminase	Homo sapiens	46-51
11125308-6	2000	We suggest that the low IL-1 production in H2(b) spleen cultures is secondary to lower T cell activation.	Hydrogen	43-45	interleukin 1 complex	Mus musculus	24-28
32028110-8	2020	We identified 6 potential natural neuroprotective molecules that are similar in their chemical structure to neuroprotective molecules and have a high number of hydrogen bonds with alpha-synuclein.	Hydrogen	160-168	synuclein alpha	Homo sapiens	180-195
32292127-2	2020	Hydrogen (H2), a flammable, colorless, and odorless gas, has been observed to have preventive and therapeutic effects on brain trauma and other neurological disorders, but its exact mechanism has not been fully clarified.Methods: To further study the mechanism underlying the role of hydrogen gas in alleviating BBB damage after TBI, we performed the scratch injury model on cultured brain microvascular endothelial cells (bEnd.3), which formed the microvascular endothelial barrier - an integral part of the highly specialized BBB.Results: In the case of TBI, hydrogen was able to improve the decline of cell viability induced by TBI.	Hydrogen	0-8	BEN domain containing 3	Homo sapiens	423-429
11113602-6	2000	Pretreatment with the COX2 inhibitor NS-398 (9 mg/kg, 1h prior to kainate) inhibited the kainate-stimulated increase of 5LOX and COX2 mRNA levels.	Hydrogen	54-56	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	22-26
32108445-3	2020	Electrochemically induced hydrogen evolution catalysis studies at pH 4 invoke a mechanism, in which the rate determining step is the protonation of the reduced CoI species that gives a cobalt hydride (CoIII-H), a key intermediate towards the H-H bond formation.	Hydrogen	26-34	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	160-163
32077188-3	2020	We found that the high-index-facet bounded Rh 2 Sb RNRs/C exhibit a high NH 3 yield rate of 228.85 +- 12.96 microg h -1 mg -1 Rh at -0.45 V versus reversible hydrogen electrode (RHE), outperforming the Rh 2 Sb SNRs/C (63.07 +- 4.45 microg h -1 mg -1 Rh ) and Rh nanoparticles/C (22.82 +- 1.49 microg h -1 mg -1 Rh ), due to the enhanced adsorption and activation of N 2 on high-index facets.	Hydrogen	158-166	Rh associated glycoprotein	Homo sapiens	43-47
11113602-6	2000	Pretreatment with the COX2 inhibitor NS-398 (9 mg/kg, 1h prior to kainate) inhibited the kainate-stimulated increase of 5LOX and COX2 mRNA levels.	Hydrogen	54-56	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	129-133
11200534-0	2000	1H, 15N, and 13C NMR resonance assignments for the Eps15 homology domain of Reps1.	Hydrogen	0-2	RALBP1 associated Eps domain containing 1	Homo sapiens	76-81
11041863-6	2000	A second group of polymerases (Pol alpha, Pol beta, and T7(-)) fails to extend all non-H-bonding base pairs, indicating that these enzymes may need minor groove hydrogen bonds at both minor groove sites or that they are especially sensitive to noncanonical DNA structure or stability.	Hydrogen	161-169	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	31-40
32259555-8	2020	Furthermore, the pharmacophore model indicated the hydrogen bond acceptors and hydrogen bond donors may play critical role in the potency of flavonoids inhibition on OATP1B1.	Hydrogen	51-59	solute carrier organic anion transporter family member 1B1	Homo sapiens	166-173
32259555-8	2020	Furthermore, the pharmacophore model indicated the hydrogen bond acceptors and hydrogen bond donors may play critical role in the potency of flavonoids inhibition on OATP1B1.	Hydrogen	79-87	solute carrier organic anion transporter family member 1B1	Homo sapiens	166-173
32212617-9	2020	In situ X-ray absorption spectroscopy data confirmed that approximately 10% of the single Pd atoms in the Pd4+ state were reduced to Pd2+ during exposure to 1000 ppm H2, implying that a Pd4+   Pd2+ catalytic redox cycle accelerates the water formation reaction during hydrogen sensing.	Hydrogen	268-276	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	133-136
11041863-6	2000	A second group of polymerases (Pol alpha, Pol beta, and T7(-)) fails to extend all non-H-bonding base pairs, indicating that these enzymes may need minor groove hydrogen bonds at both minor groove sites or that they are especially sensitive to noncanonical DNA structure or stability.	Hydrogen	161-169	DNA polymerase beta	Homo sapiens	42-50
32212617-9	2020	In situ X-ray absorption spectroscopy data confirmed that approximately 10% of the single Pd atoms in the Pd4+ state were reduced to Pd2+ during exposure to 1000 ppm H2, implying that a Pd4+   Pd2+ catalytic redox cycle accelerates the water formation reaction during hydrogen sensing.	Hydrogen	268-276	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	193-196
11045617-5	2000	The NMR studies have also allowed the DNase contact surface on Im9 to be investigated through changes in backbone chemical shifts and NOEs between the two proteins determined from comparisons of 1H-1H-13C NOESY-HSQC spectra with and without 13C decoupling.	Hydrogen	195-197	colicin E8	Escherichia coli	38-43
31916329-5	2020	Instead, the reduction in intraglomerular pressures may be related to an action of SGLT2 inhibitors to interfere with the activity of sodium-hydrogen exchanger isoform 3 (NHE-3), thereby inhibiting proximal tubular sodium reabsorption and promoting tubuloglomerular feedback.	Hydrogen	134-149	solute carrier family 5 member 2	Homo sapiens	83-88
11045617-5	2000	The NMR studies have also allowed the DNase contact surface on Im9 to be investigated through changes in backbone chemical shifts and NOEs between the two proteins determined from comparisons of 1H-1H-13C NOESY-HSQC spectra with and without 13C decoupling.	Hydrogen	198-200	colicin E8	Escherichia coli	38-43
11026686-3	2000	This point is addressed in this paper, which reports some relevant results obtained on myoglobin, the hydrogen atom of molecular biology.	Hydrogen	102-110	myoglobin	Physeter catodon	87-96
32552204-2	2020	The histidine residue at position 103 is integral to the AHSP hydrogen bond formation where disruption results in an increased quantity of cytotoxic free alpha-globin chains, thereby creating a similar pathophysiology as beta-thalassemia (beta-thal).	Hydrogen	62-70	alpha hemoglobin stabilizing protein	Homo sapiens	57-61
31743711-7	2020	P13 can spontaneously bind with thrombin exosite 1 in the form of 1:1 mainly through hydrogen bonding and van der Waals force.	Hydrogen	85-93	H3 histone pseudogene 6	Homo sapiens	0-3
11018291-0	2000	Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*.	Hydrogen	83-85	nuclear receptor subfamily 1 group D member 2	Homo sapiens	50-62
32372285-4	2020	In the present study, we screened for novel [Na+] sensors involved in water intake control and identified SLC9A4 (also called sodium (Na+)/hydrogen (H+) exchanger 4 (NHE4)).	Hydrogen	139-147	solute carrier family 9 (sodium/hydrogen exchanger), member 4	Mus musculus	106-112
32372285-4	2020	In the present study, we screened for novel [Na+] sensors involved in water intake control and identified SLC9A4 (also called sodium (Na+)/hydrogen (H+) exchanger 4 (NHE4)).	Hydrogen	139-147	solute carrier family 9 (sodium/hydrogen exchanger), member 4	Mus musculus	166-170
11018291-2	2000	The solution structure of the non-palindromic 15 bp DNA duplex d(TAGAATGTAGGTCAG), the response element of Rev-erb beta for monomeric binding, was determined by 1H and 31P NMR, energy minimization with NMR-derived restraints for distances and NOE back-calculation methods.	Hydrogen	161-163	nuclear receptor subfamily 1 group D member 2	Homo sapiens	107-119
33479660-3	2020	Molecular docking showed that the five compounds formed hydrogen bonds with residues Glu173 and Leu175 of S6K1 and hydrophobic interactions with residues Val105, Leu97 and Met225, and these interactions were key elements for the inhibitory potency of the compounds.	Hydrogen	56-64	ribosomal protein S6 kinase B1	Homo sapiens	106-110
10956187-3	2000	The triplet of hydrogen bonding and CDK inhibition was reproduced by 2,6-diamino-4-cyclohexylmethyloxy-5-nitrosopyrimidine (NU6027, Ki values: CDK1, 2.5 +/- 0.4 microM; CDK2, 1.3 +/- 0.2 microM).	Hydrogen	15-23	cyclin dependent kinase 2	Homo sapiens	169-173
32070687-7	2020	These results demonstrate that a TGEV infection can inhibit NHE3 translocation and attenuates sodium-hydrogen exchange activity via the SGLT1-mediated p38MAPK/AKt2 signaling pathway, affecting cellular electrolyte absorption leading to diarrhea.	Hydrogen	94-109	solute carrier family 5 member 1	Sus scrofa	136-141
10889016-1	2000	The crystal structure of the complex formed between recombinant yeast orotidine 5"-phosphate decarboxylase and the competitive inhibitor 6-hydroxyuridine 5"-phosphate reveals the presence of four hydrogen bonds between active site residues Tyr-217 and Arg-235 and the phosphoryl group of this inhibitor.	Hydrogen	196-204	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	70-106
32266478-1	2020	The GIAO-B3LYP method was employed to calculate the isotropic NMR shielding increments of a diatomic hydrogen probe above the tetrafluoroborate (BF4-) and tetrachloroborate (BCl4-) anions in tetrahedral (Td) symmetrical structure.	Hydrogen	101-109	BCL3 transcription coactivator	Homo sapiens	174-178
10907820-8	2000	Pooled across sexes, h2 estimates for SIMF, SP8, SRIB, and SEMA were .33, .55, .51, and .42, respectively, for Angus and .20, .31, .18, and .38, respectively, for Hereford.	Hydrogen	21-23	Sp8 transcription factor	Bos taurus	44-47
32175547-9	2020	ZIF-8 prepared using terephthalic acid shows high catalytic activity with a hydrogen rate of 2333 mLH2 min-1 gcat-1 (8046 mLH2 min-1 gZn-1).	Hydrogen	76-84	LIM homeobox protein 2	Mus musculus	98-102
32175547-9	2020	ZIF-8 prepared using terephthalic acid shows high catalytic activity with a hydrogen rate of 2333 mLH2 min-1 gcat-1 (8046 mLH2 min-1 gZn-1).	Hydrogen	76-84	LIM homeobox protein 2	Mus musculus	122-126
10852703-10	2000	The presence of the helical disruption in the RGS4-G(i)(alpha)(1) X-ray structure allows for the formation of a hydrogen-bonding network within the binding pocket for G(i)(alpha)(1) on RGS4, where RGS4 residues D117, S118, and R121 interact with residue T182 from G(i)(alpha)(1).	Hydrogen	112-120	regulator of G protein signaling 4	Homo sapiens	46-50
32318537-0	2020	The Functionalized Single-Walled Carbon Nanotubes Gas Sensor With Pd Nanoparticles for Hydrogen Detection in the High-Voltage Transformers.	Hydrogen	87-95	gastrin	Homo sapiens	50-53
32149507-7	2020	For AM, AM2, and AM3, the structures with the methanol cyclic hydrogen bonded with [N1-C4(H6)] of acrylonitrile are more stable than the other H-bonded structures.	Hydrogen	62-70	adrenomedullin 2	Homo sapiens	8-11
10852703-10	2000	The presence of the helical disruption in the RGS4-G(i)(alpha)(1) X-ray structure allows for the formation of a hydrogen-bonding network within the binding pocket for G(i)(alpha)(1) on RGS4, where RGS4 residues D117, S118, and R121 interact with residue T182 from G(i)(alpha)(1).	Hydrogen	112-120	regulator of G protein signaling 4	Homo sapiens	185-189
10852703-10	2000	The presence of the helical disruption in the RGS4-G(i)(alpha)(1) X-ray structure allows for the formation of a hydrogen-bonding network within the binding pocket for G(i)(alpha)(1) on RGS4, where RGS4 residues D117, S118, and R121 interact with residue T182 from G(i)(alpha)(1).	Hydrogen	112-120	regulator of G protein signaling 4	Homo sapiens	185-189
31770723-0	2020	Ce-doped CoP nanoparticles embedded in carbon nanotubes as an efficient and durable catalyst for hydrogen evolution.	Hydrogen	97-105	caspase recruitment domain family member 16	Homo sapiens	9-12
31770723-1	2020	In this work, a cerium doped CoP nanoparticles (NPs) embedded in carbon nanotubes (CNTs) for efficient and durable hydrogen evolution was developed.	Hydrogen	115-123	caspase recruitment domain family member 16	Homo sapiens	29-32
10852710-1	2000	Glutamine 143 in human manganese superoxide dismutase (MnSOD) forms a hydrogen bond with the manganese-bound solvent molecule and is investigated by replacement using site-specific mutagenesis.	Hydrogen	70-78	superoxide dismutase 2	Homo sapiens	23-53
32075374-11	2020	Since most of the hydrogen bonding occupancies belong to Araf-D and Araf-E, the non-reducing arabinotriose is bound to protein more strongly than the reducing arabinotriose.	Hydrogen	18-26	A-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	57-61
10852710-1	2000	Glutamine 143 in human manganese superoxide dismutase (MnSOD) forms a hydrogen bond with the manganese-bound solvent molecule and is investigated by replacement using site-specific mutagenesis.	Hydrogen	70-78	superoxide dismutase 2	Homo sapiens	55-60
10852710-3	2000	Two new water molecules in Q143A MnSOD were situated in positions nearly identical with the Oepsilon1 and Nepsilon2 of the replaced Gln 143 side chain and maintained a hydrogen-bonded network connecting the manganese-bound solvent molecule to other residues in the active site.	Hydrogen	168-176	superoxide dismutase 2	Homo sapiens	33-38
10813812-0	2000	Trans-substitution of the proximal hydrogen bond in myoglobin: II.	Hydrogen	35-43	myoglobin	Physeter catodon	52-61
32107424-5	2020	As compared with the wild-type, the four variants produced substantial differences in the collective motions of loop regions, which not only promoted structural remodeling in the CDR2 (complementarity-determining region 2) loop but also in the CDR1 loop, by changing inter- and intra-loop hydrogen bonding networks.	Hydrogen	289-297	cerebellar degeneration related protein 1	Homo sapiens	244-248
10813812-2	2000	The trans-substituted histidine to glycine mutant of sperm whale myoglobin (H93G Mb) is used to study energetics of proximal hydrogen bonding, proximal ligand-heme interactions, and coupling to distal ligand binding.	Hydrogen	125-133	myoglobin	Physeter catodon	65-74
31498927-7	2020	Hydrogen bonding and interaction energy at the filament-gelsolin S1 interface indicate distinct conformations of filament barbed ends, resulting in different interactions of gelsolin S1.	Hydrogen	0-8	gelsolin	Homo sapiens	56-64
10912660-3	2000	In an earlier publication we described the relation between both the H2 and 13CO2 exhalation in breath and the measured intestinal lactase activity after consumption of 13C-lactose.	Hydrogen	69-71	lactase	Homo sapiens	131-138
31498927-7	2020	Hydrogen bonding and interaction energy at the filament-gelsolin S1 interface indicate distinct conformations of filament barbed ends, resulting in different interactions of gelsolin S1.	Hydrogen	0-8	gelsolin	Homo sapiens	174-182
31916682-7	2020	The photocurrent density of FTO IOs/CdS NRs/CdSe clusters at 1.23 V versus reversible hydrogen electrode reaches 9.2 mA cm-2 , which is 1.43 times greater than that of CdS NRs/CdSe clusters and 3.83 times of CdS NRs.	Hydrogen	86-94	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	28-31
32005101-13	2020	For Danish Jersey, wavenumbers that interact with C-H were associated to genes that are involved in fatty acid synthesis, such as AGPAT3, AGPAT6, PPARGC1A, SREBF1, and FADS1.	Hydrogen	50-53	PPARG coactivator 1 alpha	Bos taurus	146-154
10801319-9	2000	A low barrier hydrogen bond between the 4"-hydroxyl group of the sugar and O(gamma) of Ser 132 facilitates proton transfer from the sugar 4"-hydroxyl group to O(eta) of Tyr 157.	Hydrogen	14-22	endothelin receptor type A	Homo sapiens	161-164
31906622-3	2020	These unique spectra could be ascribed to differences in the patterns of intramolecular hydrogen bonds around the hydroxymethyl group at C-5 for the three rotamers and around the hydroxyl group at C-1 for the two anomers.	Hydrogen	88-96	complement C5	Homo sapiens	137-140
31906622-3	2020	These unique spectra could be ascribed to differences in the patterns of intramolecular hydrogen bonds around the hydroxymethyl group at C-5 for the three rotamers and around the hydroxyl group at C-1 for the two anomers.	Hydrogen	88-96	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	197-200
32019191-0	2020	Performance of Graphene-CdS Hybrid Nanocomposite Thin Film for Applications in Cu(In,Ga)Se2 Solar Cell and H2 Production.	Hydrogen	107-109	CDP-diacylglycerol synthase 1	Homo sapiens	24-27
31912807-0	2020	Amorphous tungsten phosphosulphide-modified CdS nanorods as a highly efficient electron-cocatalyst for enhanced photocatalytic hydrogen production.	Hydrogen	127-135	CDP-diacylglycerol synthase 1	Homo sapiens	44-47
31912807-3	2020	The activity of the 15% WPS/CdS composite catalyst is the best, and the average hydrogen production rate reached 123 257 mumol g-1 in 5 h, and the highest AQE of 9.15% is derived at 420 nm for the 15% WPS/CdS composite catalyst.	Hydrogen	80-88	CDP-diacylglycerol synthase 1	Homo sapiens	28-31
31912807-6	2020	These active sites can capture photogenerated electrons on CdS NRs quickly, and can be used for the hydrogen evolution reaction quickly, promoting the transmission and separation of photogenerated charges and inhibiting the recombination of photogenerated electron and hole pairs.	Hydrogen	100-108	CDP-diacylglycerol synthase 1	Homo sapiens	59-62
31776523-4	2020	Specifically, LAPONITE  (LAP) nanoplatelets are able to accelerate the gelation process through hydrogen bonds with polysaccharide matrices, endowing hydrogels with superior mechanical and rheological behaviors, along with better injectability and self-healing ability.	Hydrogen	96-104	LAP	Homo sapiens	14-17
31913025-1	2020	Treatment of [Ir(PPh3)3Cl] with 2-[5-(pyridin-2-yl)-1H-pyrrol-2-yl]pyridine (Hdpp) in refluxing toluene affords an unexpected pyrrole-metalated iridium(III) hydride complex, [Ir(K2C,N-dpp)(H)(Cl)(PPh3)2] (1), via Cpyrrole-H activation, while the presence of the base KOtBu as the deprotonation reagent produces a pyridine-metalated iridium(III) hydride complex, [Ir(K3C,N,N-dpp)(H)(PPh3)2] (2), via Cpyridine-H activation.	Hydrogen	213-223	protein phosphatase 4 catalytic subunit	Homo sapiens	17-21
31913025-1	2020	Treatment of [Ir(PPh3)3Cl] with 2-[5-(pyridin-2-yl)-1H-pyrrol-2-yl]pyridine (Hdpp) in refluxing toluene affords an unexpected pyrrole-metalated iridium(III) hydride complex, [Ir(K2C,N-dpp)(H)(Cl)(PPh3)2] (1), via Cpyrrole-H activation, while the presence of the base KOtBu as the deprotonation reagent produces a pyridine-metalated iridium(III) hydride complex, [Ir(K3C,N,N-dpp)(H)(PPh3)2] (2), via Cpyridine-H activation.	Hydrogen	399-410	protein phosphatase 4 catalytic subunit	Homo sapiens	17-21
31560152-6	2020	The results indicate that 20 residues in group A of the hierarchical tree are responsible for major contributions, and van der Waals interactions as well as hydrogen bonding interactions between important residues in HSP90 and key regions of inhibitors are the main force for promoting inhibitor bindings.	Hydrogen	157-165	heat shock protein 90 alpha family class A member 1	Homo sapiens	217-222
33029593-5	2020	Pt1@CNQDs/CNS provides a well-defined photocatalytic system in which the electron and proton transfer processes that lead to the formation of hydrogen gas can be investigated.	Hydrogen	142-150	zinc finger protein 77	Homo sapiens	0-3
33029593-7	2020	Surface bound hydrogen atoms appear to diffuse from CNQDs surface sites to the deposited Pt1 catalytic sites leading to higher hydrogen-atom fugacity surrounding each isolated Pt1 site.	Hydrogen	14-22	zinc finger protein 77	Homo sapiens	89-92
33029593-7	2020	Surface bound hydrogen atoms appear to diffuse from CNQDs surface sites to the deposited Pt1 catalytic sites leading to higher hydrogen-atom fugacity surrounding each isolated Pt1 site.	Hydrogen	14-22	zinc finger protein 77	Homo sapiens	176-179
33029593-7	2020	Surface bound hydrogen atoms appear to diffuse from CNQDs surface sites to the deposited Pt1 catalytic sites leading to higher hydrogen-atom fugacity surrounding each isolated Pt1 site.	Hydrogen	127-135	zinc finger protein 77	Homo sapiens	89-92
33029593-7	2020	Surface bound hydrogen atoms appear to diffuse from CNQDs surface sites to the deposited Pt1 catalytic sites leading to higher hydrogen-atom fugacity surrounding each isolated Pt1 site.	Hydrogen	127-135	zinc finger protein 77	Homo sapiens	176-179
31702499-9	2020	RESULT: The PI3K/AKT signaling pathway was significantly activated, while FoxO1, Bim, and Caspase-3 mRNA and protein levels were significantly decreased in the hydrogen-rich water group compared with those in the pre-ischemic and ischemic phase groups.	Hydrogen	160-168	Bcl2-like 11	Rattus norvegicus	81-84
31702499-10	2020	PI3K, AKT and p-AKT mRNA and protein expression levels were increased, while the FoxO1, Bim and Caspase-3 expression levels were significantly decreased in the hydrogen-water group compared with those in the control group in the ischemia-reperfusion phase (P&amp;lt;0.05).	Hydrogen	160-168	Bcl2-like 11	Rattus norvegicus	88-91
31809978-10	2020	Thymidylate synthase, a target of pemetrexed, was downregulated in H2452 cells transfected with siROR1.	Hydrogen	67-72	thymidylate synthetase	Homo sapiens	0-20
31808484-3	2019	Hence, the heat-treated ReSe2@PCC with enhanced charge transport is by far the best performance electrode for the hydrogen evolution reaction (HER) among the state-of-the-art ReX2-based electrodes.	Hydrogen	114-122	RNA exonuclease 2	Homo sapiens	175-179
31306959-3	2019	1H NMR studies revealed the binding sites of chemosensor 1, where C-5 hydrogen and amine hydrogens formed hydrogen bonding with F- ion.	Hydrogen	0-2	complement C5	Homo sapiens	66-69
31306959-3	2019	1H NMR studies revealed the binding sites of chemosensor 1, where C-5 hydrogen and amine hydrogens formed hydrogen bonding with F- ion.	Hydrogen	70-78	complement C5	Homo sapiens	66-69
31653339-0	2019	Structural Insights into ceNAP1 Chaperoning Activity toward ceH2A-H2B.	Hydrogen	66-69	Nucleosome Assembly Protein	Caenorhabditis elegans	25-31
10819158-6	2000	Structure activity relationships of this series of compounds revealed that a hydrophobic cholesteryl side chain, 3beta-hydroxy group and a C-6 nitrogen containing a hydrogen atom at position-6 are crucial for activity.	Hydrogen	165-173	complement C6	Homo sapiens	139-142
11498372-3	2000	Co-crystallization with CDK2 shows that these flat heterocyclic hydrophobic compounds bind through two or three hydrogen bonds with the side chains of two amino acids located in the ATP-binding pocket of the kinase.	Hydrogen	112-120	cyclin dependent kinase 2	Homo sapiens	24-28
10702277-6	2000	X-ray crystallography of PTP1B complexed with OBA and related non-phosphate low molecular weight derivatives reveals that the binding mode of these molecules to a large extent mimics that of the natural substrate including hydrogen bonding to the PTP signature motif.	Hydrogen	223-231	protein tyrosine phosphatase receptor type U	Homo sapiens	25-28
10763510-4	2000	The hydrogen clearance method was applied to measure rCBF.	Hydrogen	4-12	CCAAT/enhancer binding protein zeta	Rattus norvegicus	53-57
10784028-0	2000	1H-NMR determination of the solution structure and absolute configuration of FR134043, a novel inhibitor of human leukocyte elastase.	Hydrogen	0-2	elastase, neutrophil expressed	Homo sapiens	114-132
10620356-3	2000	The chiral labeled cystine ((2)H(beta2)-cystine) was prepared by selective hydrogen exchange catalyzed by cystathionine gamma-synthase.	Hydrogen	75-83	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	33-38
10668857-3	2000	In addition to renal filtration, sorbitol [elimination half-life (t1/2beta) approximately 1h] and glycerol (t1/2beta 0.2 to 1h) are metabolised, mainly by the liver.	Hydrogen	124-126	interleukin 1 receptor like 1	Homo sapiens	108-116
10838019-6	2000	Properties associated with the size of the molecular surface, polarizability and hydrogen bonding had the largest impact on the P-glycoprotein-associated ATPase activity.	Hydrogen	81-89	dynein axonemal heavy chain 8	Homo sapiens	154-160
31653339-4	2019	We have solved high-resolution crystal structures of Caenorhabditis elegans NAP1 (ceNAP1) in complex with its cognate substrates: the C. elegans H2A-H2B dimer (ceH2A-H2B) and the H2A.Z-H2B dimer (ceH2A.Z-H2B).	Hydrogen	145-158	Nucleosome Assembly Protein	Caenorhabditis elegans	76-80
31653339-4	2019	We have solved high-resolution crystal structures of Caenorhabditis elegans NAP1 (ceNAP1) in complex with its cognate substrates: the C. elegans H2A-H2B dimer (ceH2A-H2B) and the H2A.Z-H2B dimer (ceH2A.Z-H2B).	Hydrogen	145-158	Nucleosome Assembly Protein	Caenorhabditis elegans	82-88
31653339-4	2019	We have solved high-resolution crystal structures of Caenorhabditis elegans NAP1 (ceNAP1) in complex with its cognate substrates: the C. elegans H2A-H2B dimer (ceH2A-H2B) and the H2A.Z-H2B dimer (ceH2A.Z-H2B).	Hydrogen	149-152	Nucleosome Assembly Protein	Caenorhabditis elegans	76-80
31653339-4	2019	We have solved high-resolution crystal structures of Caenorhabditis elegans NAP1 (ceNAP1) in complex with its cognate substrates: the C. elegans H2A-H2B dimer (ceH2A-H2B) and the H2A.Z-H2B dimer (ceH2A.Z-H2B).	Hydrogen	149-152	Nucleosome Assembly Protein	Caenorhabditis elegans	82-88
31653339-4	2019	We have solved high-resolution crystal structures of Caenorhabditis elegans NAP1 (ceNAP1) in complex with its cognate substrates: the C. elegans H2A-H2B dimer (ceH2A-H2B) and the H2A.Z-H2B dimer (ceH2A.Z-H2B).	Hydrogen	183-188	Nucleosome Assembly Protein	Caenorhabditis elegans	76-80
31653339-4	2019	We have solved high-resolution crystal structures of Caenorhabditis elegans NAP1 (ceNAP1) in complex with its cognate substrates: the C. elegans H2A-H2B dimer (ceH2A-H2B) and the H2A.Z-H2B dimer (ceH2A.Z-H2B).	Hydrogen	183-188	Nucleosome Assembly Protein	Caenorhabditis elegans	82-88
31653339-5	2019	Our structural and biochemical data reveals the acidic concave surface is relevant to tetramerization, and uncovers how a ceNAP1 homodimer uses its concave surface to asymmetrically recognize a ceH2A-H2B or ceH2A.Z-H2B heterodimer.	Hydrogen	200-203	Nucleosome Assembly Protein	Caenorhabditis elegans	122-128
10617140-8	2000	Therefore, the conserved serine residues in TMV of the D2 dopamine receptor are involved in hydrogen bonding interactions with selected antagonists and most agonists tested and also enable agonists to stabilise receptor-G protein coupling.	Hydrogen	92-100	dopamine receptor D2	Homo sapiens	55-75
31653339-5	2019	Our structural and biochemical data reveals the acidic concave surface is relevant to tetramerization, and uncovers how a ceNAP1 homodimer uses its concave surface to asymmetrically recognize a ceH2A-H2B or ceH2A.Z-H2B heterodimer.	Hydrogen	215-218	Nucleosome Assembly Protein	Caenorhabditis elegans	122-128
31653339-6	2019	Intriguingly, an "acidic strip" within the concave surface of ceNAP1 is crucial for binding histones, including H2A-H2B, H3-H4, and histone variants.	Hydrogen	112-119	Nucleosome Assembly Protein	Caenorhabditis elegans	62-68
31653339-6	2019	Intriguingly, an "acidic strip" within the concave surface of ceNAP1 is crucial for binding histones, including H2A-H2B, H3-H4, and histone variants.	Hydrogen	121-126	Nucleosome Assembly Protein	Caenorhabditis elegans	62-68
12712706-6	1999	The results showed that exogenous lactase can significantly decrease the incidence of lactose malabsorption (the abnormal expiration of H2 decreased from 100% to 48.9%) and milk intolerance symptoms(from 51.1% to 13.3%).	Hydrogen	136-138	lactase	Homo sapiens	34-41
31493740-4	2019	In the present in silico investigation, a structure-based pharmacophore model was generated with hydrogen bond donor, hydrogen bond acceptor and hydrophobic features complementary to crucial residues Ala55, Lys58, Asp93, Ile96, Met98 and Thr184 directed at inhibiting the ATP-binding activity of Hsp90.	Hydrogen	97-105	heat shock protein 90 alpha family class A member 1	Homo sapiens	296-301
31535412-16	2019	In addition, H2 inhalation also inhibited BLM-induced epithelial-mesenchymal transitions (EMT) by inhibiting TGF-beta1 to increase the expression level of epithelial cell marker E-cadherin while decrease the expression level of mesenchymal cell marker vimentin in a time-dependent manner.	Hydrogen	13-15	cadherin 1	Rattus norvegicus	178-188
31491512-8	2019	Moreover, the results of molecular docking showed the interaction between tannic acid and alpha-glucosidase was mainly driven by hydrogen bond, electrostatic, and hydrophobic interaction.	Hydrogen	129-137	sucrase-isomaltase	Homo sapiens	90-107
10488113-0	1999	Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase.	Hydrogen	17-25	superoxide dismutase 2	Homo sapiens	67-97
31518867-5	2019	Molecular docking studies suggest that the binding process of these compounds with heat shock protein 90 (Hsp90), BHb and HHb is a spontaneous molecular interaction process, in which van der Waals forces and hydrogen bonds play major roles, and pi-pi interaction also has influence on binding process.	Hydrogen	208-216	heat shock protein 90 alpha family class A member 1	Homo sapiens	83-104
31518867-5	2019	Molecular docking studies suggest that the binding process of these compounds with heat shock protein 90 (Hsp90), BHb and HHb is a spontaneous molecular interaction process, in which van der Waals forces and hydrogen bonds play major roles, and pi-pi interaction also has influence on binding process.	Hydrogen	208-216	heat shock protein 90 alpha family class A member 1	Homo sapiens	106-111
31546174-5	2019	Post-processing the docked poses with MM/GBSA and parallel computation of electrostatic potential maps point towards a potential weakening of one of the crucial hydrogen bonds (hinge) within the ATP-binding pocket of JAK3.	Hydrogen	161-169	Janus kinase 3	Homo sapiens	217-221
31984197-4	2019	According to various nuclear magnetic resonance experiments for mutants of C113 and molecular dynamics (MD) simulation of wild-type Pin1, the protonation sate of Sgamma of C113 regulates the hydrogen-bonding network of the dual-histidine motif (H59, H157) whose dynamics may affect substrate binding ability.	Hydrogen	191-199	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	132-136
31984197-7	2019	The principal component analysis for both MD trajectories clearly elucidated that the mutation C113A suppressed the dynamics of Pin1 because it stabilized a hydrogen-bond between Ne of H59 and Ogamma of S115.	Hydrogen	157-165	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	128-132
31795294-0	2019	Path Integral Calculation of the Hydrogen/Deuterium Kinetic Isotope Effect in Monoamine Oxidase A-Catalyzed Decomposition of Benzylamine.	Hydrogen	33-41	monoamine oxidase A	Homo sapiens	78-97
31795294-3	2019	In this work, we focus on MAO A-catalyzed benzylamine decomposition in order to elucidate nuclear quantum effects through the calculation of the hydrogen/deuterium (H/D) kinetic isotope effect.	Hydrogen	145-153	monoamine oxidase A	Homo sapiens	26-31
31849603-5	2019	Restoration of HDAC1 and HDAC2 activities (as evident from the increased acetylation of histones H3 and H4) using simvastatin significantly improves the cognitive deficit and social interaction behavior in AS mice.	Hydrogen	104-106	histone deacetylase 1	Mus musculus	15-20
32184970-3	2020	Cocrystallization of 5 with MTH1 revealed the ligand in a Phi-cis-N-(pyridin-2-yl)acetamide conformation enabling a key intramolecular hydrogen bond and polar interactions with residues Gly34 and Asp120.	Hydrogen	135-143	nudix hydrolase 1	Rattus norvegicus	28-32
31616882-8	2019	The mechanisms that contribute dominantly to the observed rate constants are: chlorine abstractions for CCl4, CHCl3, Cl3Ac-, and ClH; proton-coupled electron transfer (PCET) for IAc-; water-assisted PCET and iodine abstraction for IAm; ortho-addition for BrU and NO2U; and hydrogen atom abstraction from the sulphur atom for Cys+.	Hydrogen	273-281	C-C motif chemokine ligand 4	Homo sapiens	104-108
31603662-3	2019	Benefiting from the highly porous nanostructure and conductive carbon skeleton, H-CoP@NC is capable of working as highly active and durable bifunctional electrocatalyst for both hydrogen and oxygen evolution reaction.	Hydrogen	178-186	caspase recruitment domain family member 16	Homo sapiens	82-85
31491412-10	2019	Molecular docking studies revealed that LASSBio-294 and LASSBio-897 interact with active sites of the eNOS (endothelial nitric oxide synthase) enzymes through hydrogen bonds.	Hydrogen	159-167	nitric oxide synthase 3, endothelial cell	Mus musculus	102-106
31659813-6	2019	The results acquired from fluorescence spectroscopy revealed that the interaction of ellagic acid with tyrosinase depended on hydrogen bond and electrostatic force.	Hydrogen	126-134	tyrosinase	Mus musculus	103-113
31659813-7	2019	In addition, computational docking showed that ellagic acid interacted with amino acid residues of tyrosinase (Asn19 and Lys372) by hydrogen bond and produced electrostatic interaction with amino residue Lys18.	Hydrogen	132-140	tyrosinase	Mus musculus	99-109
31365167-4	2019	As a result of this new electronic property, PdP2 -loaded g-C3 N4 nanosheets exhibit 4 times higher photocatalytic H2 production activity than the state-of-art N-coordinated PdSAs supported on g-C3 N4 nanosheets.	Hydrogen	115-117	pyruvate dehydrogenase phosphatase catalytic subunit 2	Homo sapiens	45-49
30919308-0	2019	1H, 13C and 15N resonance assignments for the tandem CUE domains from chromatin remodeler SMARCAD1.	Hydrogen	0-2	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	Homo sapiens	90-98
31390113-0	2019	Modeling Thioredoxin Reductase-Like Activity with Cyclic Selenenyl Sulfides: Participation of an NH   Se Hydrogen Bond through Stabilization of the Mixed Se-S Intermediate.	Hydrogen	105-113	peroxiredoxin 5	Homo sapiens	9-30
31390113-4	2019	A model study that used synthetic selenenyl sulfides, which mimic the active site structure of human TrxR comprising Cys497, Sec498, and His472, suggested that His472 can play a key role by forming a hydrogen bond with the Se atom of the mixed Se-S intermediate to facilitate the second step.	Hydrogen	200-208	peroxiredoxin 5	Homo sapiens	101-105
31009237-5	2019	Docking analysis reveled that three curcumin derivatives have the best affinity for AXL and formed a hydrogen bond with the important amino acid residues in the binding pocket.	Hydrogen	101-109	AXL receptor tyrosine kinase	Homo sapiens	84-87
31141217-4	2019	The two inhibitor-bound structures reveal that Ser52, a nonconserved residue in the ATP binding pocket in Hsp90alpha, provides additional stability to PU-11-trans through a water-mediated hydrogen-bonding network.	Hydrogen	188-196	heat shock protein 90 alpha family class A member 1	Homo sapiens	106-116
31574107-6	2019	When hydrogen gas was infused into a bag containing cold ETK organ preservation solution at a pressure of 0.06 MPa and the bag was subsequently opened to the air, the dissolved hydrogen concentration remained at 1.0 mg/L or more for 4 hours.	Hydrogen	5-13	BMX non-receptor tyrosine kinase	Homo sapiens	57-60
31574107-7	2019	After warm ischemic injury was induced by circulatory arrest for 30 minutes, donor kidneys were harvested and perfused for 5 minutes with hydrogen-containing cold ETK solution or hydrogen-free cold ETK solution.	Hydrogen	138-146	BMX non-receptor tyrosine kinase	Homo sapiens	163-166
31574107-8	2019	The perfusion rate was faster from the initial stage with hydrogen-containing cold ETK solution than with hydrogen-free ETK solution.	Hydrogen	58-66	BMX non-receptor tyrosine kinase	Homo sapiens	83-86
31460547-0	2019	Retraction: Synthesis of octahedral, truncated octahedral, and cubic Rh2Ni nanocrystals and their structure-activity relationship for the decomposition of hydrazine in aqueous solution to hydrogen.	Hydrogen	188-196	Rh associated glycoprotein	Homo sapiens	69-72
31460547-1	2019	Retraction of "Synthesis of octahedral, truncated octahedral, and cubic Rh2Ni nanocrystals and their structure-activity relationship for the decomposition of hydrazine in aqueous solution to hydrogen" by Chun Li et al., Nanoscale, 2016, 8, 7043-7055.	Hydrogen	191-199	Rh associated glycoprotein	Homo sapiens	72-75
31533274-7	2019	It was quite evident from obtained thermodynamic attributes that RT spontaneously binds to hTf with a postulated existence of hydrogen bonding or Van der Waals forces.	Hydrogen	126-134	coagulation factor III, tissue factor	Homo sapiens	91-94
31555044-7	2019	The results show that while the hydrogen bond is important for Ab/Fab binding to H3, the H5-Ab/Fab system may need cation-pi interaction for a strong interaction.	Hydrogen	32-40	FA complementation group B	Homo sapiens	66-69
31555044-7	2019	The results show that while the hydrogen bond is important for Ab/Fab binding to H3, the H5-Ab/Fab system may need cation-pi interaction for a strong interaction.	Hydrogen	32-40	FA complementation group B	Homo sapiens	95-98
31185411-3	2019	Following our previous work related to the modification of the hydrogen bond network between alpha-GalCer and CD1d, we have now focused our attention on the synthesis of 3-deoxy-3,3-difluoro- and 3,4-dideoxy-3,3,4,4-tetrafluoro-alpha-GalCer analogues, and studied their ability to stimulate human iNKT cells.	Hydrogen	63-71	CD1d molecule	Homo sapiens	110-114
31389460-3	2019	The bifurcate dihydrogen-bonded complexes are the active intermediates of the first proton transfer in the step-wise alcoholysis of LPd(BH4), yielding eventually [(LPd)2(mu,eta1,2:eta1,2-BH4)]+.	Hydrogen	14-24	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	132-135
31389460-3	2019	The bifurcate dihydrogen-bonded complexes are the active intermediates of the first proton transfer in the step-wise alcoholysis of LPd(BH4), yielding eventually [(LPd)2(mu,eta1,2:eta1,2-BH4)]+.	Hydrogen	14-24	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	164-167
31389460-3	2019	The bifurcate dihydrogen-bonded complexes are the active intermediates of the first proton transfer in the step-wise alcoholysis of LPd(BH4), yielding eventually [(LPd)2(mu,eta1,2:eta1,2-BH4)]+.	Hydrogen	14-24	secreted phosphoprotein 1	Homo sapiens	173-177
31389460-3	2019	The bifurcate dihydrogen-bonded complexes are the active intermediates of the first proton transfer in the step-wise alcoholysis of LPd(BH4), yielding eventually [(LPd)2(mu,eta1,2:eta1,2-BH4)]+.	Hydrogen	14-24	secreted phosphoprotein 1	Homo sapiens	180-184
2585511-4	1989	We find that the amide hydrogen bond is stable by 8.4 kcal/mol in CCl4, and by 0.3 kcal/mol in water.	Hydrogen	23-31	C-C motif chemokine ligand 4	Homo sapiens	66-70
2585511-5	1989	Our results indicate also that the hydrogen-bonded dimer is 2.2 kcal/mol more stable in water than it is in CCl4.	Hydrogen	35-43	C-C motif chemokine ligand 4	Homo sapiens	108-112
2489081-5	1989	However in the case of L-arabinose, Arg 151 forms hydrogen bonds with the hydroxyl group at the C-4 atom and the ring oxygen, whereas in case of D-galactose it forms bonds with the hydroxyl groups at the C-4 and C-6 atoms of the pyranose ring.	Hydrogen	50-58	complement C4A (Rodgers blood group)	Homo sapiens	96-99
2775744-0	1989	1H NMR studies of bovine and porcine phospholipase A2: assignment of aromatic resonances and evidence for a conformational equilibrium in solution.	Hydrogen	0-2	LOC104974671	Bos taurus	37-53
2501983-0	1989	Characterization of CNS lesions by using high-resolution 1H MR spectroscopy of CSF: preliminary results.	Hydrogen	57-59	colony stimulating factor 2	Homo sapiens	79-82
10488113-1	1999	Histidine 30 in human manganese superoxide dismutase (MnSOD) is located at a site partially exposed to solvent with its side chain participating in a hydrogen-bonded network that includes the active-site residues Tyr(166) and Tyr(34) and extends to the manganese-bound solvent molecule.	Hydrogen	150-158	superoxide dismutase 2	Homo sapiens	22-52
31487825-10	2019	By analyzing the internal mechanism of the PUF-SiO2 interfacial interaction, it was found that hydrogen bonds play a major role in the interaction between PUF and nano-SiO2.	Hydrogen	95-103	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	43-46
31487825-10	2019	By analyzing the internal mechanism of the PUF-SiO2 interfacial interaction, it was found that hydrogen bonds play a major role in the interaction between PUF and nano-SiO2.	Hydrogen	95-103	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	155-158
10488113-1	1999	Histidine 30 in human manganese superoxide dismutase (MnSOD) is located at a site partially exposed to solvent with its side chain participating in a hydrogen-bonded network that includes the active-site residues Tyr(166) and Tyr(34) and extends to the manganese-bound solvent molecule.	Hydrogen	150-158	superoxide dismutase 2	Homo sapiens	54-59
31487825-11	2019	Moreover, hydrogen bonds can be formed between the polar atoms of the PUF chain and the hydroxyl groups (-OH) as well as O atoms on the surface of SiO2.	Hydrogen	10-18	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	70-73
31487825-12	2019	Hydrogen bonds interactions are involved in adsorption of PUF chains on the SiO2 surface, reducing the distance between PUF chains and making the system denser, thus enhancing the mechanical properties of PUF materials.	Hydrogen	0-8	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	58-61
10549134-1	1999	The classical Linderstrom-Lang hydrogen exchange (HX) model is extended to describe the relationship between the HX behaviors (EX1 and EX2) and protein folding kinetics for the amide protons that can only exchange by global unfolding in a three-state system including native (N), intermediate (I), and unfolded (U) states.	Hydrogen	31-39	FERM domain containing 6	Homo sapiens	127-130
31487825-12	2019	Hydrogen bonds interactions are involved in adsorption of PUF chains on the SiO2 surface, reducing the distance between PUF chains and making the system denser, thus enhancing the mechanical properties of PUF materials.	Hydrogen	0-8	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	120-123
31487825-12	2019	Hydrogen bonds interactions are involved in adsorption of PUF chains on the SiO2 surface, reducing the distance between PUF chains and making the system denser, thus enhancing the mechanical properties of PUF materials.	Hydrogen	0-8	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	120-123
30939252-0	2019	Involvement of the Akt-dependent CREB signaling pathway in hydrogen-peroxide-induced early growth response protein-1 expression in rat vascular smooth muscle cells 1.	Hydrogen	59-67	cAMP responsive element binding protein 1	Rattus norvegicus	33-37
10549137-0	1999	Assignment of the 1H, 15N, and 13C resonances of the C-terminal domain of frataxin, the protein responsible for Friedreich ataxia.	Hydrogen	18-20	frataxin	Homo sapiens	74-82
10555585-0	1999	Heme methyl 1H chemical shifts as structural parameters in some low-spin ferriheme proteins.	Hydrogen	12-14	HEME	Bos taurus	0-4
31361084-0	2019	Hierarchically Porous W-Doped CoP Nanoflake Arrays as Highly Efficient and Stable Electrocatalyst for pH-Universal Hydrogen Evolution.	Hydrogen	115-123	caspase recruitment domain family member 16	Homo sapiens	30-33
31361084-6	2019	The outstanding electrocatalytic performance of W-CoP NAs/CC can be mainly attributed to the porous W-doped nanoflake arrays, which not only afford rich exposed active sites, but also accelerate the access of electrolytes and the diffusion of H2 bubbles, thus efficiently promoting the HER performance.	Hydrogen	243-245	caspase recruitment domain family member 16	Homo sapiens	50-53
10469174-5	1999	RESULTS: The two-dimensional (2D) 1H-15N correlation spectrum of 15N labeled MBF1 indicated that MBF1 consists of both flexible and well structured parts.	Hydrogen	34-36	endothelial differentiation related factor 1	Homo sapiens	97-101
31429568-0	2019	Correction to "Pt-like Hydrogen Evolution Electrocatalysis on PANI/CoP Hybrid Nanowires by Weakening the Shackles of Hydrogen Ions on the Surfaces of Catalysts".	Hydrogen	23-31	caspase recruitment domain family member 16	Homo sapiens	67-70
31429568-0	2019	Correction to "Pt-like Hydrogen Evolution Electrocatalysis on PANI/CoP Hybrid Nanowires by Weakening the Shackles of Hydrogen Ions on the Surfaces of Catalysts".	Hydrogen	117-125	caspase recruitment domain family member 16	Homo sapiens	67-70
31051338-0	2019	Coupling Co2P and CoP nanoparticles with copper ions incorporated Co9S8 nanowire arrays for synergistically boosting hydrogen evolution reaction electrocatalysis.	Hydrogen	117-125	caspase recruitment domain family member 16	Homo sapiens	18-21
31115145-1	2019	A highly efficient Z-scheme photocatalytic system constructed with 1D CdS and 2D CoS2 exhibited high photocatalytic hydrogen-evolution activity of 5.54 mmol h-1  g-1 with an apparent quantum efficiency of 10.2 % at 420 nm.	Hydrogen	116-124	CDP-diacylglycerol synthase 1	Homo sapiens	70-73
2726457-3	1989	The recent solutions of single crystal DNA dodecamer structures with segments of oligo-A.oligo-T have revealed the presence of a high propeller twist in the AT regions which is stabilized by the formation of bifurcated (three-center) hydrogen bonds on the floor of the major groove, involving the N6 amino group of adenine hydrogen bonding to two O4 atoms of adjacent thymine residues on the opposite strand.	Hydrogen	234-242	Dopamine transporter	Drosophila melanogaster	157-159
2726457-3	1989	The recent solutions of single crystal DNA dodecamer structures with segments of oligo-A.oligo-T have revealed the presence of a high propeller twist in the AT regions which is stabilized by the formation of bifurcated (three-center) hydrogen bonds on the floor of the major groove, involving the N6 amino group of adenine hydrogen bonding to two O4 atoms of adjacent thymine residues on the opposite strand.	Hydrogen	323-331	Dopamine transporter	Drosophila melanogaster	157-159
2930185-0	1989	Hydrogen-1 nuclear magnetic resonance studies of staphylococcal nuclease variant H124L: pH dependence of histidines and tyrosines.	Hydrogen	0-8	nuclease	Escherichia coli	64-72
2930185-1	1989	The pH dependence of the 1H NMR spectrum of staphylococcal nuclease H124L was investigated as a function of the binding of Ca2+, the ion required for enzymatic activity, and deoxythymidine-3",5"-diphosphate (pdTp), a competitive inhibitor.	Hydrogen	25-27	nuclease	Escherichia coli	59-67
2930185-3	1989	Of the observable ring protons of the three histidine residues, only the C delta 1H of His46 shows a large chemical shift perturbation on formation of the ternary complex, (nuclease H124L).pdTp.Ca2+.	Hydrogen	81-83	nuclease	Escherichia coli	173-181
2525050-6	1989	The absorption maxima of bovine artificial pigments formed by regenerating opsin with the 11-cis dihydro series of chromophores support a color regulation model for bovine rhodopsin in which the chromophore-binding site of the protein has two negative charges: one directly hydrogen bonded to the Schiff base nitrogen and another near carbon-13.	Hydrogen	274-282	rhodopsin	Bos taurus	172-181
3243762-4	1988	Both 1H-NMR and 13C-NMR showed that the signals of protons and carbons at O-CH3, C-1, and C-2 positions were shifted downfield due to the formation of a double bond between the C-1 and C-2, and that each signal derived from O-CH3, C-1, or C-2 position was divided into two signals due to the formation of cis and trans isomers of the alkenylmethylether.	Hydrogen	5-7	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	81-84
3243762-4	1988	Both 1H-NMR and 13C-NMR showed that the signals of protons and carbons at O-CH3, C-1, and C-2 positions were shifted downfield due to the formation of a double bond between the C-1 and C-2, and that each signal derived from O-CH3, C-1, or C-2 position was divided into two signals due to the formation of cis and trans isomers of the alkenylmethylether.	Hydrogen	5-7	complement C2	Homo sapiens	90-93
10354406-3	1999	Evaluation of the O-methyl ether derivative of 4 suggested that the 3-hydroxymethyl substituent might be involved in a hydrogen-bond donor-type of interaction at a sterically compact region in the PNMT active site.	Hydrogen	119-127	phenylethanolamine N-methyltransferase	Homo sapiens	197-201
3243762-4	1988	Both 1H-NMR and 13C-NMR showed that the signals of protons and carbons at O-CH3, C-1, and C-2 positions were shifted downfield due to the formation of a double bond between the C-1 and C-2, and that each signal derived from O-CH3, C-1, or C-2 position was divided into two signals due to the formation of cis and trans isomers of the alkenylmethylether.	Hydrogen	5-7	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	177-180
3243762-4	1988	Both 1H-NMR and 13C-NMR showed that the signals of protons and carbons at O-CH3, C-1, and C-2 positions were shifted downfield due to the formation of a double bond between the C-1 and C-2, and that each signal derived from O-CH3, C-1, or C-2 position was divided into two signals due to the formation of cis and trans isomers of the alkenylmethylether.	Hydrogen	5-7	complement C2	Homo sapiens	185-188
3243762-4	1988	Both 1H-NMR and 13C-NMR showed that the signals of protons and carbons at O-CH3, C-1, and C-2 positions were shifted downfield due to the formation of a double bond between the C-1 and C-2, and that each signal derived from O-CH3, C-1, or C-2 position was divided into two signals due to the formation of cis and trans isomers of the alkenylmethylether.	Hydrogen	5-7	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	177-180
3243762-4	1988	Both 1H-NMR and 13C-NMR showed that the signals of protons and carbons at O-CH3, C-1, and C-2 positions were shifted downfield due to the formation of a double bond between the C-1 and C-2, and that each signal derived from O-CH3, C-1, or C-2 position was divided into two signals due to the formation of cis and trans isomers of the alkenylmethylether.	Hydrogen	5-7	complement C2	Homo sapiens	185-188
9945873-0	1988	Diffusion of hydrogen in Nb1-yVy alloys.	Hydrogen	13-21	CD177 molecule	Homo sapiens	25-28
3416869-4	1988	The data indicate that the C-2 hydroxyl group of galactose is involved in weak interactions as a hydrogen-bond acceptor with uncharged groups of EIL and EAL.	Hydrogen	97-105	complement C2	Homo sapiens	27-30
10411265-3	1999	Cell-free extracts enriched for PrpE catalysed the formation of propionyl-CoA in a propionate-, ATP-, Mg2+- and HS-CoA dependent manner.	Hydrogen	112-114	propionate--CoA ligase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	32-36
3191510-9	1988	For CF4-C4, such intramolecular hydrogen-bonding appears to involve OH-4 and OH-6 of the beta-D-Galp group.	Hydrogen	32-40	galanin like peptide	Homo sapiens	96-100
10678142-3	1999	Regional cerebral blood flow (rCBF) in caudate nucleus was determined by hydrogen clearance method.	Hydrogen	73-81	CCAAT/enhancer binding protein zeta	Rattus norvegicus	30-34
3172203-0	1988	Allosteric energy at the hemoglobin beta chain C terminus studied by hydrogen exchange.	Hydrogen	69-77	hemoglobin subunit beta	Homo sapiens	25-40
10193193-5	1999	The 1H-nmr experiments and the constrained molecular dynamics simulations showed the twisted "figure 8" conformers for [Gly] and [Phe]ASCs and the "square" conformer for [Leu]ASC in the DMSO solution.	Hydrogen	4-6	steroid sulfatase	Mus musculus	134-137
3172204-0	1988	Salt, phosphate and the Bohr effect at the hemoglobin beta chain C terminus studied by hydrogen exchange.	Hydrogen	87-95	hemoglobin subunit beta	Homo sapiens	43-58
3172204-1	1988	Hydrogen exchange experiments using functional labeling and fragment separation methods were performed to study interactions at the C terminus of the hemoglobin beta subunit that contribute to the phosphate effect and the Bohr effect.	Hydrogen	0-8	hemoglobin subunit beta	Homo sapiens	150-165
3421932-6	1988	The isotope effect at C-2 of lactate in the enzymic reaction (1.0048 +/- 0.0004) is attributed to the hydrogen transfer step from lactate to the coenzyme.	Hydrogen	102-110	complement C2	Homo sapiens	22-25
10202185-8	1999	Comparison of the dose-response curves between TPA-induced hydrogen (H+) secretion, as measured by aminopyrine (AP) uptake, and the membrane-associated PKC-alpha suggests that translocation of PKC-alpha is not involved in the H+ secretory process in PC.	Hydrogen	59-67	protein kinase C alpha type	Oryctolagus cuniculus	193-202
3131763-2	1988	In this paper, we report the use of 1H and 13C NMR spectroscopy to study the fluctuations in conformation of the anti-bacterial drug trimethoprim when it is bound to its "target," dihydrofolate reductase.	Hydrogen	36-38	dihydrofolate reductase	Homo sapiens	180-203
3263364-0	1988	Tertiary structure of mouse epidermal growth factor determined by two-dimensional 1H NMR.	Hydrogen	82-84	epidermal growth factor	Mus musculus	28-51
10365907-8	1999	IP was unaltered, and pH(I) decreased as hydrogen ions produced during bicarbonate secretion were dissipated (7.41 +/- 0.01 versus 7.38 +/- 0.01, P &lt; 0.05).	Hydrogen	41-49	glucose-6-phosphate isomerase	Homo sapiens	22-27
10051427-3	1999	Here we investigate the solution structure of monomeric NAP-2 by multi-dimensional 1H-NMR and 15N-NMR spectroscopy and computational modelling.	Hydrogen	83-85	pro-platelet basic protein	Homo sapiens	56-61
2966074-0	1988	Site directed mutants of human interleukin-1 alpha: a 1H-NMR and receptor binding study.	Hydrogen	54-56	interleukin 1 alpha	Homo sapiens	31-50
10074370-6	1999	Interestingly, deoxynucleotides of Pf1 DNA exhibit sugars in the C2"-endo/anti conformation and bases that are largely unstacked, compared with C3"-endo/anti conformers and very strong base stacking in fd DNA; hydrogen-bonding interactions of thymine carbonyls are also different in Pf1 and fd.	Hydrogen	210-218	PHD finger protein 12	Homo sapiens	35-38
3260496-1	1988	The three-dimensional structure of the mouse epidermal growth factor (EGF) in solution was studied by comparison of the 1H NMR spectra of alpha EGF (1-53) and beta EGF (2-53, des-asparaginyl 1 form).	Hydrogen	120-122	epidermal growth factor	Mus musculus	45-68
3260496-1	1988	The three-dimensional structure of the mouse epidermal growth factor (EGF) in solution was studied by comparison of the 1H NMR spectra of alpha EGF (1-53) and beta EGF (2-53, des-asparaginyl 1 form).	Hydrogen	120-122	epidermal growth factor	Mus musculus	70-73
10074370-8	1999	The results indicate markedly different modes of organization of ssDNA in Pf1 and fd virions, despite similar environments for coat protein tyrosines, and suggest strong hydrogen-bonding interactions between DNA bases and coat subunits of Pf1 but not between those of fd.	Hydrogen	170-178	PHD finger protein 12	Homo sapiens	239-242
10037716-0	1999	The accessibility of iron at the active site of recombinant human phenylalanine hydroxylase to water as studied by 1H NMR paramagnetic relaxation.	Hydrogen	115-117	phenylalanine hydroxylase	Homo sapiens	66-91
3370298-0	1988	Hydrogen exchange of the tryptophan residues in bovine alpha-lactalbumin studied by UV spectroscopy.	Hydrogen	0-8	lactalbumin alpha	Bos taurus	55-72
10095786-1	1999	The three-dimensional solution structure of the alpha-subunit in the alpha, beta heterodimeric human chorionic gonadotropin (hCG), deglycosylated with endo-beta-N-acetylglucosaminidase-B (dg-alpha hCG), was determined using 2D homonuclear and 2D heteronuclear 1H, 13C NMR spectroscopy at natural abundance in conjunction with the program package XPLOR.	Hydrogen	260-262	chorionic gonadotropin subunit beta 5	Homo sapiens	125-128
2837287-1	1988	Proton nuclear magnetic resonance (1H NMR) assignments for the murine epidermal growth factor (mEGF) in aqueous solution were determined by using two-dimensional NMR at pH 3.1 and 28 degrees C. The assignments are complete for all backbone hydrogen atoms, with the exception of the N-terminal amino group, and for 46 of the 53 side chains.	Hydrogen	35-37	epidermal growth factor	Mus musculus	95-99
9988688-5	1999	This effect is not observed in the presence of EF-1alpha and GDP or EF-Tu.GTP and requires association of valyl-tRNA synthetase within the ValRS.EF-1H complex.	Hydrogen	148-150	valyl-tRNA synthetase 1	Homo sapiens	106-127
2837287-1	1988	Proton nuclear magnetic resonance (1H NMR) assignments for the murine epidermal growth factor (mEGF) in aqueous solution were determined by using two-dimensional NMR at pH 3.1 and 28 degrees C. The assignments are complete for all backbone hydrogen atoms, with the exception of the N-terminal amino group, and for 46 of the 53 side chains.	Hydrogen	240-248	epidermal growth factor	Mus musculus	70-93
2837287-1	1988	Proton nuclear magnetic resonance (1H NMR) assignments for the murine epidermal growth factor (mEGF) in aqueous solution were determined by using two-dimensional NMR at pH 3.1 and 28 degrees C. The assignments are complete for all backbone hydrogen atoms, with the exception of the N-terminal amino group, and for 46 of the 53 side chains.	Hydrogen	240-248	epidermal growth factor	Mus musculus	95-99
31320940-4	2019	The aluminol and siloxane groups on the surface of HNT facilitate the formation of hydrogen bonding with the biomaterials onto its surface.	Hydrogen	83-91	ras responsive element binding protein 1	Homo sapiens	51-54
9988688-5	1999	This effect is not observed in the presence of EF-1alpha and GDP or EF-Tu.GTP and requires association of valyl-tRNA synthetase within the ValRS.EF-1H complex.	Hydrogen	148-150	valyl-tRNA synthetase 1	Homo sapiens	139-144
30978352-5	2019	Point mutation of the residue Tyr422 of TEAD4 protein would disrupt the relevant hydrogen bond and even abolish the interaction.	Hydrogen	81-89	TEA domain family member 4	Mus musculus	40-45
2896638-0	1988	Conformation of D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 (CTP-NH2), a highly selective mu-opioid antagonist peptide, by 1H and 13C n.m.r.	Hydrogen	119-121	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	44-47
9925788-5	1999	Based on these results, the structure of (52-96)Vpr was analysed by two-dimensional 1H-NMR in aqueous TFE (30%) solution and refined by restrained molecular dynamics.	Hydrogen	84-86	Vpr	Human immunodeficiency virus 1	48-51
2896638-4	1988	Solvent shielding of the Cys2 amide proton, observed in variable temperature experiments, suggests an orientation of this amide proton toward the gem dimethyls of Pen7 with possible hydrogen bonding to the Thr6 carbonyl oxygen, and a dihedral angle of -110 degrees for the disulfide bond.	Hydrogen	182-190	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	163-166
31341700-6	2019	Ni(II)-NBP is active for photo-induced H2 evolution following a reductive quenching mechanism.	Hydrogen	39-41	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	7-10
31341700-7	2019	Ni(II)-NBP catalyzed H+ reduction to H2 gas electrochemically as well.	Hydrogen	37-39	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	7-10
10191473-0	1999	Structural features of a peptide corresponding to human kappa-casein residues 84-101 by 1H-nuclear magnetic resonance spectroscopy.	Hydrogen	88-90	casein kappa	Homo sapiens	56-68
30919765-6	2019	Hydrogen bond were important for the binding of all peptides but SASPA and AQSPA had the highest hydrogen bonds interactions with the alpha-glucosidase and alpha-amylase, respectively.	Hydrogen	0-8	sucrase-isomaltase	Homo sapiens	134-151
30919765-6	2019	Hydrogen bond were important for the binding of all peptides but SASPA and AQSPA had the highest hydrogen bonds interactions with the alpha-glucosidase and alpha-amylase, respectively.	Hydrogen	97-105	sucrase-isomaltase	Homo sapiens	134-151
2896788-0	1988	The discrimination between human, porcine and bovine insulin with 1H NMR spectroscopy.	Hydrogen	66-68	insulin	Bos taurus	53-60
2896788-1	1988	The 1H- and 1H-1H correlation (COSY) NMR spectra of human, porcine and bovine insulin have been recorded.	Hydrogen	4-6	insulin	Bos taurus	78-85
2896788-1	1988	The 1H- and 1H-1H correlation (COSY) NMR spectra of human, porcine and bovine insulin have been recorded.	Hydrogen	12-14	insulin	Bos taurus	78-85
2896788-1	1988	The 1H- and 1H-1H correlation (COSY) NMR spectra of human, porcine and bovine insulin have been recorded.	Hydrogen	12-14	insulin	Bos taurus	78-85
3030818-2	1987	The interaction between horse cytochrome c and the tryptic fragment of bovine liver microsomal cytochrome b5 in the absence and presence of [Cr(ethylenediamine)3]Cl3 was studied by 1H NMR spectroscopy.	Hydrogen	181-183	cytochrome c, somatic	Equus caballus	30-42
31277205-0	2019	Hydrogen/Deuterium Dynamics in Hydroxyl Salts Co2(OH)3Br/Co2(OD)3Br Revealed by Muon Spin Relaxation.	Hydrogen	0-8	complement C2	Homo sapiens	57-67
31277205-2	2019	The deuterium atoms in Co2(OD)3Br were found to be rapidly fluctuating at high temperatures, which should be arising as a quantum atomic effect due to the small mass of deuterium, then they drastically slowed down toward Tc = 250 K where a broad anomaly appeared in the dielectric response, and finally became quasi-static at around 180 K. Meanwhile, the hydrogen atoms in Co2(OH)3Br also exhibited a two-step slowing at ~240 K and ~180 K, respectively.	Hydrogen	355-363	complement C2	Homo sapiens	23-33
31277205-4	2019	The present study suggested the effectiveness of the muSR technique on revealing the hydrogen/deuterium (H/D) dynamics in Co2(OH)3Br/Co2(OD)3Br.	Hydrogen	85-93	complement C2	Homo sapiens	133-143
10025963-15	1999	The data indicate that the His-81 in the second transmembrane domain of the PGF2alpha receptor in concert with Arg-291 in the seventh transmembrane domain may be involved in ligand binding, most likely not by ionic interaction with the prostaglandin"s carboxyl group but rather as a hydrogen bond donor.	Hydrogen	283-291	prostaglandin F receptor	Homo sapiens	76-94
31035108-3	2019	In this work, as a proof-of-concept, we studied the production of the theranostic radionuclide 67Cu (T1/2 = 62 h) via the reaction of a 70Zn beam at 15 MeV/nucleon with a hydrogen gas target.	Hydrogen	171-179	CD5 molecule	Homo sapiens	101-110
9826510-5	1998	The MUC1 peptide is bound both by non-polar interactions and hydrogen bonds in an elongated groove in the antibody-combining site through interactions with Complimentarity Determining Regions (CDRs), three of the light chain (L1, L2, L3) and two of the heavy chain (H1 and H3).	Hydrogen	61-69	mucin 1, cell surface associated	Homo sapiens	4-8
3567176-2	1987	1H NMR has been used to characterize and compare the structures of antithrombin III from human, bovine, and porcine plasma as well as to investigate the interactions of each of these proteins with heparin fragments of defined length.	Hydrogen	0-2	serpin family C member 1	Homo sapiens	67-83
11672362-3	1998	The cyano group was utilized to introduce a C-8beta angular hydrogen, while the chloro ester moiety served as an entry to the geminal hydrogens at C-4.	Hydrogen	60-68	complement C8 beta chain	Homo sapiens	44-51
2429692-0	1986	Identification of 1H resonances from the bait region of human alpha 2-macroglobulin and effects of proteases and methylamine.	Hydrogen	18-20	alpha-2-macroglobulin	Homo sapiens	62-83
2429692-1	1986	The 1H NMR spectrum of human alpha 2-macroglobulin, Mr 716,000, consists of predominantly extremely broad unresolved resonances but also has nine relatively sharp (delta nu 1/2 less than 25 Hz) resonances from aromatic residues.	Hydrogen	4-6	alpha-2-macroglobulin	Homo sapiens	29-50
9893941-4	1998	Analysis of the crystal structure of cytochrome c oxidase shows the existence of hydrogen-bonded networks of amino acid residues which could undergo redox-linked pK shifts resulting in transmembrane proton translocation.	Hydrogen	81-89	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	37-57
3768297-1	1986	Proton nuclear magnetic resonance (1H NMR) has been used to study the nature of the interaction between tropomyosin (TM) and troponin T (Tn-T).	Hydrogen	35-37	troponin T1, slow skeletal type	Homo sapiens	125-135
3768297-1	1986	Proton nuclear magnetic resonance (1H NMR) has been used to study the nature of the interaction between tropomyosin (TM) and troponin T (Tn-T).	Hydrogen	35-37	troponin T1, slow skeletal type	Homo sapiens	137-141
3768297-2	1986	Resonances corresponding to the histidine residues in fragments of both TM and Tn-T can be resolved and assigned in the 1H NMR spectrum.	Hydrogen	120-122	troponin T1, slow skeletal type	Homo sapiens	79-83
3729426-1	1986	1H-NMR spectra for the angiotensin agonist sarcosine-(Sar)Arg-Val-Tyr-Ile-His-Sar-Phe [( Sar1,Sar7]Ang II) and the antagonist Sar-Arg-Val-Tyr-Ile-His-Sar-Ile in dimethylsulfoxide-d6 were examined at 400 MHz.	Hydrogen	0-2	secretion associated Ras related GTPase 1A	Homo sapiens	89-105
9738725-6	1998	The rate of breath H2 excretion was much higher with LAC (1.34 +/- 0.98 mL/h) than with SC (0.27 +/- 0.29, P = .029).	Hydrogen	19-21	lactase	Homo sapiens	53-56
3487786-1	1986	We have determined the structure of cDNA and two genomic genes encoding steroid 21-hydroxylase [21-OHase; steroid 21-monooxygenase; steroid, hydrogen-donor:oxygen oxidoreductase (21-hydroxylating); EC 1.14.99.10].	Hydrogen	141-149	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	72-94
3487786-1	1986	We have determined the structure of cDNA and two genomic genes encoding steroid 21-hydroxylase [21-OHase; steroid 21-monooxygenase; steroid, hydrogen-donor:oxygen oxidoreductase (21-hydroxylating); EC 1.14.99.10].	Hydrogen	141-149	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	96-104
9738725-8	1998	Increased breath H2 excretion with LAC may relate to fermentation of nonlactose sugar or to ill-defined changes in colonic physiology or motility, which could enhance colonic fermentation of malabsorbed sugar by H2-producing bacteria.	Hydrogen	17-19	lactase	Homo sapiens	35-38
9738725-8	1998	Increased breath H2 excretion with LAC may relate to fermentation of nonlactose sugar or to ill-defined changes in colonic physiology or motility, which could enhance colonic fermentation of malabsorbed sugar by H2-producing bacteria.	Hydrogen	212-214	lactase	Homo sapiens	35-38
9681992-7	1998	Collectively, these data demonstrate the existence of a microsomal P450-dependent in-chain fatty acid desaturase system distinct from the well-documented cytochrome b5-linked CoA desaturases and suggest further that CYP3A1-dependent formation of Delta3-VPA arises via nonselective, initial hydrogen atom abstraction from either the C-3 or the C-4 position.	Hydrogen	290-298	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	216-222
2940089-0	1986	1H-NMR studies at 500 MHz of a neutral disaccharide and sulphated di-, tetra-, hexa- and larger oligosaccharides obtained by endo-beta-galactosidase treatment of keratan sulphate.	Hydrogen	0-2	galactosidase beta 1	Bos taurus	130-148
9745898-5	1998	Of the three secondary structural elements, helical structure formed by the N-terminal residues, Asp1-Ile11 appears to be more rigid as observed by the relatively very slow exchange of amide hydrogens of Glu5-Ile11.	Hydrogen	191-200	nudix hydrolase 11	Homo sapiens	97-101
2872895-4	1986	Preincubation of HGT-1 cells for 10 min with H2 antagonists at 2 microM concentration resulted in 90-100% inactivation (SKF 93479 and oxmetidine) and 65% inactivation (ranitidine) which persisted for 30 min, even after a washout period.	Hydrogen	45-47	solute carrier family 25 member 16	Homo sapiens	17-22
3718973-9	1986	These data indicate that the steroid-binding site of hSBP and rSBP is a nonpolar cavity containing a proton acceptor that participates in a specific interaction, possibly a hydrogen bond, with the 3"-hydroxyl group of the bound steroid.	Hydrogen	173-181	spermine binding protein	Rattus norvegicus	62-66
9752005-0	1998	1H, 13C and 15N NMR resonance assignments of vaccinia glutaredoxin-1 in the fully reduced form.	Hydrogen	0-2	glutaredoxin	Homo sapiens	54-68
9693068-11	1998	CD and preliminary 1H NMR experiments show that purified Sss1p solubilized in SDS micelles is very stable and adopts a helical secondary structure.	Hydrogen	19-21	translocon subunit SSS1	Saccharomyces cerevisiae S288C	57-62
2874262-4	1986	Based on the similar stereoposition of identically charged atoms and lateral side chain (R) with respect to the alpha-hydrogen atoms in beta-sheet conformation and in D-amino acids, it is proposed that its substrates may include several membrane-related proteins, partially in beta-sheet conformation, whose alpha-hydrogen atoms would be the real object of D-amino acid oxidase catalysis.	Hydrogen	118-126	D-amino acid oxidase	Homo sapiens	357-377
2874262-4	1986	Based on the similar stereoposition of identically charged atoms and lateral side chain (R) with respect to the alpha-hydrogen atoms in beta-sheet conformation and in D-amino acids, it is proposed that its substrates may include several membrane-related proteins, partially in beta-sheet conformation, whose alpha-hydrogen atoms would be the real object of D-amino acid oxidase catalysis.	Hydrogen	314-322	D-amino acid oxidase	Homo sapiens	357-377
3484709-2	1986	In histamine-stimulated tissues, the initial rise and subsequent rapid fall in potential difference, rise in resistance, and inhibition of hydrogen ion (H+) secretion induced by SAN did not occur with ASAN unless hydrolysis of ASAN produced a SAN of greater than 3 mM.	Hydrogen	139-147	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	178-181
9620970-4	1998	Analysis of the nucleotide sequence of the hcnABC genes showed that each HCN synthase subunit was similar to known enzymes involved in hydrogen transfer, i.e., to formate dehydrogenase (for HcnA) or amino acid oxidases (for HcnB and HcnC).	Hydrogen	135-143	DUF3108 domain-containing protein	Pseudomonas protegens CHA0	171-184
3486513-1	1986	Distal RTA is characterized by decreased distal renal tubular hydrogen ion secretion, decreased ability to acidify urine, hypercalciuria, hyperphosphaturia, hypocitraturia, and metabolic acidosis.	Hydrogen	62-70	MAS related GPR family member F	Homo sapiens	7-10
9659815-0	1998	The myocardial sodium-hydrogen exchanger (NHE) and its role in mediating ischemic and reperfusion injury.	Hydrogen	22-30	solute carrier family 9 member C1	Homo sapiens	42-45
4066692-4	1985	The paramagnetic hyperfine shifts in the cytochrome b5 1H NMR spectrum are perturbed by metMb, indicating the formation of a specific bimolecular complex with a 1:1 stoichiometry and a binding constant estimated to be less than 10 microM.	Hydrogen	55-57	cytochrome b5 type A	Homo sapiens	41-54
9659815-1	1998	A major mechanism by which the heart adapts to intracellular acidosis during ischemia and recovers from the acidosis after reperfusion is through the sodium-hydrogen exchanger (NHE).	Hydrogen	157-165	solute carrier family 9 member C1	Homo sapiens	177-180
3000430-0	1985	Two-dimensional 1H NMR studies of cytochrome c.	Hydrogen	16-18	cytochrome c, somatic	Equus caballus	34-46
9537988-11	1998	A solvent hydrogen isotope effect near 2 for kcat in catalysis by Q143N hMnSOD indicates rate-contributing proton transfers to form product hydroperoxide anion or hydrogen peroxide.	Hydrogen	10-18	superoxide dismutase 2	Homo sapiens	72-78
4010285-8	1985	Our results therefore show that estrogen formation in the brain occurs with the same stereospecificity of hydrogen loss at C-1 and C-2 as in placental microsomes.	Hydrogen	106-114	complement C2	Rattus norvegicus	123-134
9510177-6	1998	Additional experiments suggested that the level of IgG3 autoantibody production, which is controlled by H2, may be important in the pathogenesis of renal disease.	Hydrogen	104-106	Immunoglobulin heavy constant gamma 3	Mus musculus	51-55
31054998-4	2019	IL-17A-blocking assay and docking analysis showed that FA interacted with Trp-67, Gln-94, and Glu-95 residues of IL-17A via hydrogen bonds and consequently abolished the binding of IL-17RA to IL-17A.	Hydrogen	124-132	interleukin 17 receptor A	Mus musculus	181-188
9551103-1	1998	The refolding kinetics of the chemically denatured SH3 domain of phosphatidylinositol 3"-kinase (PI3-SH3) have been monitored by real-time one-dimensional 1H NMR coupled with a variety of other biophysical techniques.	Hydrogen	155-157	peptidase inhibitor 3	Homo sapiens	97-100
31327088-4	2019	The binding stoichiometry was determined by Job"s plot and the probable sensing mechanism of the probe towards Cd2+ was investigated by employing FTIR spectra analysis and 1H NMR titration experiments.	Hydrogen	172-174	CD2 molecule	Homo sapiens	111-114
9761677-0	1998	Fragile X DNA triplet repeats, (GCC)n, form hairpins with single hydrogen-bonded cytosine.cytosine mispairs at the CpG sites: isotope-edited nuclear magnetic resonance spectroscopy on (GCC)n with selective 15N4-labeled cytosine bases.	Hydrogen	65-73	guanylate cyclase 2C	Homo sapiens	32-35
31182582-7	2019	If all cavities are fully occupied by hydrogen molecules, the EMT ice hydrate can easily outperform the record hydrogen storage capacity of 5.3 wt % achieved with sII hydrogen hydrate.	Hydrogen	38-46	IL2 inducible T cell kinase	Homo sapiens	62-65
31182582-7	2019	If all cavities are fully occupied by hydrogen molecules, the EMT ice hydrate can easily outperform the record hydrogen storage capacity of 5.3 wt % achieved with sII hydrogen hydrate.	Hydrogen	111-119	IL2 inducible T cell kinase	Homo sapiens	62-65
31182582-7	2019	If all cavities are fully occupied by hydrogen molecules, the EMT ice hydrate can easily outperform the record hydrogen storage capacity of 5.3 wt % achieved with sII hydrogen hydrate.	Hydrogen	111-119	IL2 inducible T cell kinase	Homo sapiens	62-65
31182582-10	2019	Compared with those of ice XI (0.93 g/cm3), both the bending and stretching vibrational modes of the EMT ice are blue-shifted due to their weaker hydrogen bonds.	Hydrogen	146-154	IL2 inducible T cell kinase	Homo sapiens	101-104
11939061-2	1998	Regional CBF was determined by hydrogen clearance method at 15 min before, 15 and 30 min thereafter once every 30 min up to 180 min after the beginning of SAH.	Hydrogen	31-39	CCAAT/enhancer binding protein zeta	Rattus norvegicus	9-12
31221956-3	2019	Here we probe the global Na+- and dopamine-induced conformational dynamics of the wild-type Drosophila melanogaster dopamine transporter using hydrogen-deuterium exchange mass spectrometry.	Hydrogen	143-151	Dopamine transporter	Drosophila melanogaster	116-136
30990231-6	2019	Theoretical calculations further showed that P-deficient Ru2 P has a lower free energy of hydrogen adsorption on the surface than other two, P-rich Ru phosphides (RuP, RuP2 ), which confirms the excellent intrinsic HER activity of Ru2 P and is consistent with experiment results.	Hydrogen	90-98	doublecortin domain containing 2	Homo sapiens	57-60
9461294-0	1997	Three-dimensional solution structure of human angiogenin determined by 1H,15N-NMR spectroscopy--characterization of histidine protonation states and pKa values.	Hydrogen	71-73	angiogenin	Homo sapiens	46-56
31045344-0	2019	Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb.	Hydrogen	30-38	FA complementation group B	Homo sapiens	96-99
9416731-1	1997	BACKGROUND: Sodium (Na+)-hydrogen (H+) exchange (NHE) inhibitors are effective cardioprotective agents.	Hydrogen	25-33	solute carrier family 9 member C1	Homo sapiens	49-52
30896373-2	2019	The results of FTIR, 1H NMR and 13C NMR showed that the reaction occurred between primary amino group of arginine in GH and epoxy of PSiQAEp.	Hydrogen	21-23	gamma-glutamyl hydrolase	Homo sapiens	117-119
9461349-0	1997	Assessment by 1H NMR spectroscopy of the structural behaviour of human parathyroid-hormone-related protein(1-34) and its close relationship with the N-terminal fragments of human parathyroid hormone in solution.	Hydrogen	14-16	parathyroid hormone like hormone	Homo sapiens	71-106
31017442-5	2019	31P{1H}-NMR study suggested the involvement of an aryloxyphosphonium intermediate and/or possibly 2-iodobenzoxazole which activates the C-2 position of benzoxazolones toward nucleophilic aromatic substitution.	Hydrogen	4-6	complement C2	Homo sapiens	136-139
30706621-2	2019	In this work, FA decomposes to generate CO2 and H2 selectively in the presence of aqueous Pd2+ complex solutions at 333 K. Pd(NO3 )2 was the most effective in generating H2 among various Pd2+ complexes explored.	Hydrogen	170-172	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	90-93
30706621-2	2019	In this work, FA decomposes to generate CO2 and H2 selectively in the presence of aqueous Pd2+ complex solutions at 333 K. Pd(NO3 )2 was the most effective in generating H2 among various Pd2+ complexes explored.	Hydrogen	170-172	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	187-190
30706621-4	2019	Since C-H activation reaction of Pd2+ -bound formate is occurred for both Pd2+ reduction and H2 /CO2 gas generation, FA decomposition pathways using several Pd2+ species were explored using density functional theory (DFT) calculations.	Hydrogen	93-95	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	33-36
30951745-6	2019	Meanwhile, CIH-induced endoplasmic reticulum stress was decreased by H2 as the expressions of CHOP, caspase-12, and GRP78 were down-regulated.	Hydrogen	69-71	DNA-damage inducible transcript 3	Rattus norvegicus	94-98
30951745-10	2019	H2 could inhibit the activation of p38 and JNK, suggesting H2 played an active part in resisting renal injury via MAPK.	Hydrogen	0-2	mitogen-activated protein kinase 8	Rattus norvegicus	43-46
9461349-7	1997	The similarity in behaviour of hPTHrP(1-34) and the N-terminal fragments of PTH under various solution conditions is shown from the 1H NMR data presented here and an extensive review of the literature data.	Hydrogen	132-134	parathyroid hormone like hormone	Homo sapiens	31-37
30951745-10	2019	H2 could inhibit the activation of p38 and JNK, suggesting H2 played an active part in resisting renal injury via MAPK.	Hydrogen	59-61	mitogen-activated protein kinase 8	Rattus norvegicus	43-46
30951745-11	2019	SIGNIFICANCE: Taken together, our study reveals that H2 can ameliorate CIH-induced kidney injury by decreasing endoplasmic reticulum stress and activating autophagy through inhibiting oxidative stress-dependent p38 and JNK MAPK activation.	Hydrogen	53-55	mitogen-activated protein kinase 8	Rattus norvegicus	219-222
9398156-0	1997	Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.	Hydrogen	125-133	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-104
30950262-0	2019	Robust NiCoP/CoP Heterostructures for Highly Efficient Hydrogen Evolution Electrocatalysis in Alkaline Solution.	Hydrogen	55-63	caspase recruitment domain family member 16	Homo sapiens	9-12
9379452-10	1997	Alternatively, the CB2 selectivities may be a results of an amino acid change from a hydrogen bond-accepting residue in CB1 to a hydrogen bond-donating residue in CB2.	Hydrogen	85-93	cannabinoid receptor 1 (brain)	Mus musculus	120-123
30950262-2	2019	Herein, we report a highly active and stably heterostructural electrocatalyst consisting of NiCoP nanowires decorated with CoP nanoparticles on a nickel foam (NiCoP-CoP/NF) for effective hydrogen evolution.	Hydrogen	187-195	caspase recruitment domain family member 16	Homo sapiens	94-97
30950262-2	2019	Herein, we report a highly active and stably heterostructural electrocatalyst consisting of NiCoP nanowires decorated with CoP nanoparticles on a nickel foam (NiCoP-CoP/NF) for effective hydrogen evolution.	Hydrogen	187-195	caspase recruitment domain family member 16	Homo sapiens	123-126
30950262-4	2019	Combined with the integrated catalyst design, NiCoP-CoP/NF affords a remarkable hydrogen evolution performance in terms of high activity, enhanced kinetics, and outstanding durability in an alkaline electrolyte, superior to most of the Co (or Ni)-phosphide-based catalysts reported previously.	Hydrogen	80-88	caspase recruitment domain family member 16	Homo sapiens	48-51
9379452-10	1997	Alternatively, the CB2 selectivities may be a results of an amino acid change from a hydrogen bond-accepting residue in CB1 to a hydrogen bond-donating residue in CB2.	Hydrogen	129-137	cannabinoid receptor 1 (brain)	Mus musculus	120-123
9331414-10	1997	The lifetimes of pairs C2.C8+ and 5mC1.C7+ are 1 ms and 1 s, respectively, at 15 degrees C. Anomalous exchange properties of the T3 imino proton indicate hydrogen bonding to A6 N7 via a water bridge.	Hydrogen	154-162	VPS52 subunit of GARP complex	Homo sapiens	43-48
30735837-0	2019	Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence.	Hydrogen	40-48	sirtuin 3	Mus musculus	0-5
30735837-6	2019	Mechanistic analysis revealed that hydrogen significantly inhibited the downregulation of Sirt3 expression, and this notion was confirmed using AICAR, which restores Sirt3 expression and activity.	Hydrogen	35-43	sirtuin 3	Mus musculus	90-95
30735837-6	2019	Mechanistic analysis revealed that hydrogen significantly inhibited the downregulation of Sirt3 expression, and this notion was confirmed using AICAR, which restores Sirt3 expression and activity.	Hydrogen	35-43	sirtuin 3	Mus musculus	166-171
30735837-7	2019	Moreover, hydrogen reduced the expression of p53, p21 and p16 and the number of blue-green precipitations in the retinas of NaIO3 mice as assessed by SA-beta-gal staining.	Hydrogen	10-18	transformation related protein 53, pseudogene	Mus musculus	45-48
30969123-6	2019	Furthermore, molecular docking revealed that the DPP-IV inhibitory peptides were predicted to form hydrogen-bonds, pi-pi bonds, and charge interactions with the activity sites, especially the amino acid residues located in the S2 pocket of DPP-IV, potentially contributing to their DPP-IV inhibitory activities.	Hydrogen	99-107	dipeptidyl peptidase 4	Homo sapiens	49-55
30969123-6	2019	Furthermore, molecular docking revealed that the DPP-IV inhibitory peptides were predicted to form hydrogen-bonds, pi-pi bonds, and charge interactions with the activity sites, especially the amino acid residues located in the S2 pocket of DPP-IV, potentially contributing to their DPP-IV inhibitory activities.	Hydrogen	99-107	dipeptidyl peptidase 4	Homo sapiens	240-246
30969123-6	2019	Furthermore, molecular docking revealed that the DPP-IV inhibitory peptides were predicted to form hydrogen-bonds, pi-pi bonds, and charge interactions with the activity sites, especially the amino acid residues located in the S2 pocket of DPP-IV, potentially contributing to their DPP-IV inhibitory activities.	Hydrogen	99-107	dipeptidyl peptidase 4	Homo sapiens	240-246
9275236-9	1997	The structures of human destrin and yeast cofilin indicate a hydrogen distance of 2.61 and 2.77 A, respectively, with corresponding bond angles of 99.5 degrees and 113 degrees, close to the optimum for a strong hydrogen bond.	Hydrogen	61-69	destrin, actin depolymerizing factor	Homo sapiens	24-31
31019306-8	2019	The binding site is extremely compact, and ligands interact with MT1 mainly by strong aromatic stacking with Phe179 and auxiliary hydrogen bonds with Asn162 and Gln181.	Hydrogen	130-138	metallothionein 1I, pseudogene	Homo sapiens	65-68
9275236-9	1997	The structures of human destrin and yeast cofilin indicate a hydrogen distance of 2.61 and 2.77 A, respectively, with corresponding bond angles of 99.5 degrees and 113 degrees, close to the optimum for a strong hydrogen bond.	Hydrogen	211-219	destrin, actin depolymerizing factor	Homo sapiens	24-31
9300485-0	1997	Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy.	Hydrogen	104-106	apolipoprotein C1	Homo sapiens	75-93
30869872-0	2019	The Hsp90 Chaperone: 1H and 19F Dynamic Nuclear Magnetic Resonance Spectroscopy Reveals a Perfect Enzyme.	Hydrogen	21-23	heat shock protein 90 alpha family class A member 1	Homo sapiens	4-9
30869872-3	2019	We used 19F and 1H dynamic nuclear magnetic resonance (NMR) spectroscopy to study the opening and closing kinetics of Hsp90 and to determine the kcat for ATP hydrolysis.	Hydrogen	16-18	heat shock protein 90 alpha family class A member 1	Homo sapiens	118-123
9300485-1	1997	A peptide comprising the N-terminal 38 residues of human apolipoprotein C-I (apoC-I(1-38)) was synthesized using solid-phase methods and its solution conformation studied by CD and 1H NMR spectroscopy.	Hydrogen	181-183	apolipoprotein C1	Homo sapiens	57-75
9280297-5	1997	Comparison of near-UV circular dichroism, fluorescence and one-dimensional 1H-NMR spectra of mPrP(23-231) and mPrP(121-231) shows that the amino-terminal segment 23-120, which includes the five characteristic octapeptide repeats, does not contribute measurably to the manifestation of three-dimensional structure as detected by these techniques, indicating that the residues 121-231 might be the only polypeptide segment of PrP(C) with a defined three-dimensional structure.	Hydrogen	75-77	prion protein	Mus musculus	93-97
4005224-1	1985	High-resolution 1H nuclear magnetic resonance (NMR) spectroscopy at 300 MHz has been used to study the behavior of human gastrin in aqueous solution.	Hydrogen	16-18	gastrin	Homo sapiens	121-128
3968064-8	1985	These results provide the first direct evidence for carbanion formation via abstraction of a C-2 hydrogen by a base in the enzyme, as the first step of the catalytic pathway of acyl-CoA dehydrogenation.	Hydrogen	97-105	complement C2	Rattus norvegicus	93-96
9280297-5	1997	Comparison of near-UV circular dichroism, fluorescence and one-dimensional 1H-NMR spectra of mPrP(23-231) and mPrP(121-231) shows that the amino-terminal segment 23-120, which includes the five characteristic octapeptide repeats, does not contribute measurably to the manifestation of three-dimensional structure as detected by these techniques, indicating that the residues 121-231 might be the only polypeptide segment of PrP(C) with a defined three-dimensional structure.	Hydrogen	75-77	prion protein	Mus musculus	110-114
9280297-5	1997	Comparison of near-UV circular dichroism, fluorescence and one-dimensional 1H-NMR spectra of mPrP(23-231) and mPrP(121-231) shows that the amino-terminal segment 23-120, which includes the five characteristic octapeptide repeats, does not contribute measurably to the manifestation of three-dimensional structure as detected by these techniques, indicating that the residues 121-231 might be the only polypeptide segment of PrP(C) with a defined three-dimensional structure.	Hydrogen	75-77	prion protein	Mus musculus	94-97
9309219-9	1997	All DIM amide nitrogens donate hydrogen bonds to N and O atoms on the floor of the DNA groove and, in addition, the two Im rings on DIM2 accept hydrogen bonds from guanine N2 amines, thereby providing specific reading.	Hydrogen	144-152	thioredoxin like 4B	Homo sapiens	132-136
2859863-0	1985	[C-2 basically substituted thiazoles with H2-antagonistic action.	Hydrogen	42-44	complement C2	Rattus norvegicus	1-4
6439215-1	1984	Our previous studies have shown that 2,2-dimethyl-5-t-butyl-1,3-benzodioxole (DBBD), a methylenedioxyphenyl (MDP) analog in which the methylene hydrogens have been replaced by methyl groups, does not form an inhibitory complex with cytochrome P-450 nor induce this cytochrome.	Hydrogen	144-153	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	232-248
9251819-0	1997	A myoglobin mutant designed to mimic the oxygen-avid Ascaris suum hemoglobin: elucidation of the distal hydrogen bonding network by solution NMR.	Hydrogen	104-112	myoglobin	Physeter catodon	2-11
6434182-2	1984	The biosynthetic product had blood-group A activity and its structure was confirmed as alpha-D-GalpNAc-(1----3)-[alpha-L-Fucp-(1----2)]-beta-D-Galp-(1--- -4)-D-Glc by methylation analysis and high-resolution 1H-n.m.r.	Hydrogen	208-210	galanin like peptide	Homo sapiens	95-99
9251819-1	1997	The solution 1H NMR structure of the active site and ligand dissociation rate for the cyanomet complex have been determined for a sperm whale myoglobin triple mutant Leu29(B10)--&gt;Tyr, His64(E7)--&gt;Gln, Thr67(E10)--&gt;Arg that mimics the distal residue configuration of the oxygen-avid hemoglobin from Ascaris suum.	Hydrogen	13-15	myoglobin	Physeter catodon	142-151
9251819-5	1997	The distal Tyr29(B10) in the triple mutant provides a strong hydrogen bond to the bound cyanide comparable to that provided by His64(E7) in wild-type myoglobin.	Hydrogen	61-69	myoglobin	Physeter catodon	150-159
9214433-5	1997	TCR residues CDR1beta D30, CDR2beta N51, and CDR3beta Q97 were positioned to potentially participate in hydrogen bond interactions with the shared epitope DRbeta residues Q70 and R71.	Hydrogen	104-112	cerebellar degeneration related protein 2	Homo sapiens	27-31
6531786-1	1984	The structure of 4",4""-diethylstilbestrol quinone (DES quinone), a short-lived metabolic intermediate of the synthetic estrogen E-diethylstilbestrol (DES), was investigated by 13C- and 1H-nmr.	Hydrogen	186-188	desmin	Homo sapiens	52-55
6531786-3	1984	The 1H-nmr spectrum of DES quinone remained unchanged in the temperature range from 25 degrees C to 65 degrees C. The spectral results suggested the structure of DES quinone to be planar or time-averaged planar with the exception of the freely rotating ethyl groups.	Hydrogen	4-6	desmin	Homo sapiens	23-26
6531786-3	1984	The 1H-nmr spectrum of DES quinone remained unchanged in the temperature range from 25 degrees C to 65 degrees C. The spectral results suggested the structure of DES quinone to be planar or time-averaged planar with the exception of the freely rotating ethyl groups.	Hydrogen	4-6	desmin	Homo sapiens	162-165
9048573-13	1997	These results appear to underscore the role of gamma-phosphoryl hydrogen bonding/salt bridging in the wild-type Csk reaction transition state, which is somewhat perturbed in the D314E Csk reaction.	Hydrogen	64-72	C-terminal Src kinase	Homo sapiens	112-115
6726083-2	1984	Thus, the replacement of hydrogen with fluorine at C-4 might well modify the rate of metabolism, biological activity, and pharmacological activity of vitamin A, 4,4-Difluororetinyl acetate and related analogs were consequently synthesized by the following procedure.	Hydrogen	25-33	complement C4A (Rodgers blood group)	Homo sapiens	51-54
9048573-13	1997	These results appear to underscore the role of gamma-phosphoryl hydrogen bonding/salt bridging in the wild-type Csk reaction transition state, which is somewhat perturbed in the D314E Csk reaction.	Hydrogen	64-72	C-terminal Src kinase	Homo sapiens	184-187
6887208-3	1983	The unusual 17 beta side-chain orientation of 2 with a C16-C17-C20-O20 torsion angle of +13 degrees compared to -7 degrees for progesterone would seem to preclude hydrogen bonding with the progestin receptor binding site and provides strong supporting evidence for the contention that this site is located above the beta face of the molecule.	Hydrogen	163-171	cytokine like 1	Homo sapiens	59-62
9063871-1	1997	This paper reports a detailed conformational analysis by 1H NMR (DMSO-d6, 300 K) and molecular modeling of the octapeptide D-Phe1-Cys2-Phe3-D-Trp4-Lys5-Thr6-Cys7+ ++-Thr8-ol (disulfide bridged) known as sandostatin (or SMS 201-995 or octreotide) with both somatostatin-like and opioid-like bioactivities.	Hydrogen	57-59	dihydrolipoamide dehydrogenase	Homo sapiens	135-139
6887208-5	1983	On the other hand, some hydrogen bonding can occur in the case of 1 (C16-C17-C20-O20 = 31 degrees) despite the fact that the difference in torsion angle (24 degrees) with respect to progesterone is, in absolute values, greater than that for 2 (20 degrees).	Hydrogen	24-32	cytokine like 1	Homo sapiens	73-76
6297596-1	1983	The 1H-NMR lines of heme c and the axial ligands in reduced and oxidized Iso-1 and Iso-2 cytochromes c from Saccharomyces cerevisiae and in cytochrome c from Candida krusei were individually assigned and the conformation of the coordination sphere of the heme iron was investigated with the use of proton-proton Overhauser enhancement measurements and circular dichroism spectroscopy.	Hydrogen	4-6	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	73-78
6896683-4	1982	From kinetic analyses, it seems that oxethazaine acted as noncompetitive inhibitor of hydrogen ion on the chemoreceptors of the secretin-releasing cells in the duodenal mucosa.	Hydrogen	86-94	SCT	Canis lupus familiaris	128-136
9046019-5	1997	It is proposed that the perferryl moiety P450 Fe3+.O2.- initiates lipid peroxidation by abstracting methylene hydrogen from polyunsaturated lipid to form lipid radical, which then combines with oxygen to produce the chain propagating peroxyl radical for subsequent formation of lipid peroxides.	Hydrogen	110-118	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	41-45
9000629-1	1996	Thioredoxin exists in all organisms and is responsible for the hydrogen transfer to important enzymes for ribonucleotide reduction and the reduction of methionine sulphoxide and sulphate.	Hydrogen	63-71	thioredoxin H-type 1	Arabidopsis thaliana	0-11
6982070-7	1982	The other species present in cyanide solutions, HCN, was shown to be the substrate (Km = 4.5 mM at Av2/Av1 = 8), and extrapolation of the data indicates that at high enough HCN concentration H2 evolution can be eliminated.	Hydrogen	191-193	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	48-51
6982070-7	1982	The other species present in cyanide solutions, HCN, was shown to be the substrate (Km = 4.5 mM at Av2/Av1 = 8), and extrapolation of the data indicates that at high enough HCN concentration H2 evolution can be eliminated.	Hydrogen	191-193	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	173-176
8917652-4	1996	It was recognized that in addition to having the required pharmacophore (the 4-hydroxy group with hydrogen-bonding interaction with the two catalytic aspartic acid residues and the lactone moiety replacing the ubiquitous water molecule in the active site), these 5,6-dihydro-4-hydroxy-2-pyrones incorporated side chains at the C-6 position that appropriately extended into the S1" and S2" subsites of the enzyme active site.	Hydrogen	98-106	complement C6	Homo sapiens	327-330
6982070-11	1982	HCN appears to bind to and be reduced at an enzyme state more oxidized than the one responsible for either H2 evolution or N2 reduction.	Hydrogen	107-109	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-3
8661930-4	1996	PAL-1 also used proline, hydrogen, lactate, propionate, succinate, fumarate, pyruvate, or yeast extract as electron donors for Fe(III) reduction.	Hydrogen	25-33	Pal1p	Saccharomyces cerevisiae S288C	0-5
6813118-5	1982	Lipohydroperoxidase activity was demonstrated with 13-hydroperoxylinoleic acid plus linoleic acid as hydrogen donor under anaerobic conditions at 2 degrees C. The products were 13-hydroxylinoleic acid, oxodienes and compounds of non-diene structure similar to those produced by soybean lipoxygenase-1.	Hydrogen	101-109	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	286-298
7085670-0	1982	1H-NMR studies of the structure and stability of the bovine pancreatic secretory trypsin inhibitor.	Hydrogen	0-2	serine peptidase inhibitor Kazal type 1	Bos taurus	60-98
8641177-6	1996	Bafilomycin A, a specific inhibitor of ATP-dependent hydrogen ion pumps, also inhibited IGFBP-3 potentiation of IGF-I-stimulated [3H]AIB uptake.	Hydrogen	53-61	insulin like growth factor binding protein 3	Bos taurus	88-95
7092807-4	1982	The reversible release of the C-5 hydrogen was utilized as a measure of the enzyme activity with 5-3H-labelled chondroitin as a substrate.	Hydrogen	34-42	complement C5	Homo sapiens	30-33
30899930-8	2019	Therefore, the VHT can meet the two primary conditions of a photocatalyst for water splitting to generate H2 in SnX and O2 in SnX2.	Hydrogen	106-108	annexin A7	Homo sapiens	112-115
30225569-4	2019	Here we report backbone and side chains 1H, 13C and 15N chemical shift assignments of RbfA from Staphylococcus aureus.	Hydrogen	40-42	AT695_RS11300	Staphylococcus aureus	86-90
8928889-4	1996	After an acute myocardial infarction, we observed an initial rapid (1h) rise in VEGF (275%), flk-1 (375%), and flt-1 (400%) mRNA expression throughout the entire heart.	Hydrogen	68-70	Fms related receptor tyrosine kinase 1	Rattus norvegicus	111-116
6279533-10	1982	It has also been shown that OH radicals abstract a hydrogen atom from the sugar at C-1" and C-5" positions.	Hydrogen	51-59	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	83-86
6279533-10	1982	It has also been shown that OH radicals abstract a hydrogen atom from the sugar at C-1" and C-5" positions.	Hydrogen	51-59	complement C5	Homo sapiens	92-95
8829520-5	1996	The polar hydrogen-bonding groups such as (thio)urea, cyanoguanidine, and nitroethenediamine substructures found in histamine H2-receptor antagonists are also bioanalogous in various other bioactive compound series.	Hydrogen	10-18	histamine receptor H2	Homo sapiens	116-137
6177202-0	1982	Restriction of hydrogen and sodium ion diffusion in porcine gastric mucin: a concentration dependent phenomenon.	Hydrogen	15-23	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	60-73
30707421-0	2019	15N, 13C and 1H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus.	Hydrogen	13-15	FKBP prolyl isomerase 1A pseudogene 1	Homo sapiens	41-47
8710742-2	1996	METHODS: The self-diffusion coefficient of BS/PC aggregates in bovine submaxillary mucin (BSM) was measured by Fourier-transform pulsed-field gradient spin-echo (FT-PGSE) 1H NMR spectroscopy.	Hydrogen	171-173	mucin 1, cell surface associated	Bos taurus	83-88
6221377-1	1982	Isotope-exchange reactions (H2(18)O in equilibrium with KH2PO4) during ATP hydrolysis catalyzed by myosin and its subfragment 1 from rabbit, dog, and human cardiac muscle were studied.	Hydrogen	28-30	myosin heavy chain 14	Homo sapiens	99-105
6271696-5	1981	The first reaction, which occurs between the hydrogens of the C-2 carbon of the radicals and those of the methyl groups of the neighbouring molecules, can be followed at room temperature.	Hydrogen	45-54	complement C2	Homo sapiens	62-65
8652634-1	1996	1H-NMR spectroscopy was applied to a study of the mode of interaction, in aqueous medium in the pH range 5.2-8.5 and at low and high temperatures, between several mono- and dinucleotide analogues of the mRNA cap m7GpppG and a selected tripeptide Trp-Leu-Glu, and a tetrapeptide Trp-Glu-Asp-Glu, the sequence of which corresponds to one of the suspected binding sites in the mRNA cap-binding protein (CBP).	Hydrogen	0-2	eukaryotic translation initiation factor 4E	Homo sapiens	400-403
6271696-6	1981	The three other reactions could be conveniently monitored in gamma-irradiated polycrystalline alanine at 110 degrees C. The first of the other three reactions takes place between the methyl hydrogens of the radicals and the C-2 hydrogens of nearby molecules, while the remaining processes involve exchange between the hydrogen atoms of the amino group and those on the C-2 and C-3 carbon atoms of the deamination radical.	Hydrogen	190-199	complement C2	Homo sapiens	224-227
6271696-6	1981	The three other reactions could be conveniently monitored in gamma-irradiated polycrystalline alanine at 110 degrees C. The first of the other three reactions takes place between the methyl hydrogens of the radicals and the C-2 hydrogens of nearby molecules, while the remaining processes involve exchange between the hydrogen atoms of the amino group and those on the C-2 and C-3 carbon atoms of the deamination radical.	Hydrogen	190-199	complement C2	Homo sapiens	369-372
6271696-6	1981	The three other reactions could be conveniently monitored in gamma-irradiated polycrystalline alanine at 110 degrees C. The first of the other three reactions takes place between the methyl hydrogens of the radicals and the C-2 hydrogens of nearby molecules, while the remaining processes involve exchange between the hydrogen atoms of the amino group and those on the C-2 and C-3 carbon atoms of the deamination radical.	Hydrogen	228-237	complement C2	Homo sapiens	224-227
6271696-6	1981	The three other reactions could be conveniently monitored in gamma-irradiated polycrystalline alanine at 110 degrees C. The first of the other three reactions takes place between the methyl hydrogens of the radicals and the C-2 hydrogens of nearby molecules, while the remaining processes involve exchange between the hydrogen atoms of the amino group and those on the C-2 and C-3 carbon atoms of the deamination radical.	Hydrogen	228-237	complement C2	Homo sapiens	369-372
6271696-6	1981	The three other reactions could be conveniently monitored in gamma-irradiated polycrystalline alanine at 110 degrees C. The first of the other three reactions takes place between the methyl hydrogens of the radicals and the C-2 hydrogens of nearby molecules, while the remaining processes involve exchange between the hydrogen atoms of the amino group and those on the C-2 and C-3 carbon atoms of the deamination radical.	Hydrogen	190-198	complement C2	Homo sapiens	224-227
6271696-6	1981	The three other reactions could be conveniently monitored in gamma-irradiated polycrystalline alanine at 110 degrees C. The first of the other three reactions takes place between the methyl hydrogens of the radicals and the C-2 hydrogens of nearby molecules, while the remaining processes involve exchange between the hydrogen atoms of the amino group and those on the C-2 and C-3 carbon atoms of the deamination radical.	Hydrogen	190-198	complement C2	Homo sapiens	369-372
30879170-0	2019	Backbone and side chain 1H, 15N and 13C assignments of a putative peptidyl prolyl cis-trans isomerase FKBP12 from Mycobacterium tuberculosis.	Hydrogen	24-26	FKBP prolyl isomerase 1A pseudogene 1	Homo sapiens	102-108
30807789-5	2019	For metabolites 1 and 2, the absolute configurations at C-2 were deduced from comparison of the 1H NMR difference of their (S)- and (R)-phenylglycine methyl ester derivatives while the relative configurations were tentatively assigned by a J-based analysis and confirmed by comparison of 13C chemical shifts to literature data.	Hydrogen	96-98	complement C2	Homo sapiens	56-59
8700871-0	1996	A general two-process model describes the hydrogen exchange behavior of RNase A in unfolding conditions.	Hydrogen	42-50	ribonuclease A family member 1, pancreatic	Homo sapiens	72-79
31179095-14	2019	Conclusions: Inhalation of 2% hydrogen gas after HSR minimized the extent of lung injury by decreasing MPO activity and reducing infiltration of inflammatory cells into lung tissue.	Hydrogen	30-38	myeloperoxidase	Rattus norvegicus	103-106
30843903-1	2019	We have theoretically investigated the hydrogen abstraction reactions of H2O, H2S, CH3OH, and CH3SH by the CCl3 radical, which is of interest in atmospheric chemistry research.	Hydrogen	39-47	C-C motif chemokine ligand 3	Homo sapiens	107-111
7028115-27	1981	There may be a weaker hydrogen bond to C-6.	Hydrogen	22-30	complement C6	Rattus norvegicus	39-42
8700871-1	1996	When NMR hydrogen exchange was used previously to monitor the kinetics of RNase A unfolding, some peptide NH protons were found to show EX2 exchange (detected by base catalysis) in addition to the expected EX1 exchange, whose rate is limited by the kinetic unfolding process.	Hydrogen	9-17	ribonuclease A family member 1, pancreatic	Homo sapiens	74-81
8700871-2	1996	In earlier work, two groups showed independently that a restricted two-process model successfully fits published hydrogen exchange rates of native RNase A in the range 0-0.7 M guanidinium chloride.	Hydrogen	113-121	ribonuclease A family member 1, pancreatic	Homo sapiens	147-154
8700871-9	1996	Earlier studies showed that hydrogen exchange in native proteins typically occurs by the EX2 mechanism but that high temperatures or pH values above 7 may give rise to EX1 exchange.	Hydrogen	28-36	FERM domain containing 6	Homo sapiens	168-171
8733908-4	1996	1H-MRS must be a valuable tool to clarify the pathophysiology of DRPLA.	Hydrogen	0-2	atrophin 1	Homo sapiens	65-70
7012154-1	1981	Stereochemistry of C-1 hydrogen elimination in the aromatization of 2 beta-hydroxy-19-oxoandrostenedione.	Hydrogen	23-31	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	19-22
30941042-10	2019	Finally, molecular docking assay indicated the steady hydrogen bond was formed between Pae and Akt2.	Hydrogen	54-62	thymoma viral proto-oncogene 2	Mus musculus	95-99
30889860-7	2019	Besides, the molecular docking study disclosed that the two most potent compounds 11 and 12 have more interactions within the binding pocket of IDO-1 via hydrogen-bonding, which may account for their higher IDO-1 inhibitory activity.	Hydrogen	154-162	indoleamine 2,3-dioxygenase 1	Homo sapiens	144-149
30889860-7	2019	Besides, the molecular docking study disclosed that the two most potent compounds 11 and 12 have more interactions within the binding pocket of IDO-1 via hydrogen-bonding, which may account for their higher IDO-1 inhibitory activity.	Hydrogen	154-162	indoleamine 2,3-dioxygenase 1	Homo sapiens	207-212
8611558-10	1996	These data indicate a role of aromatic interactions in the binding of these antagonists to ETA receptors an, in the case of BMS-182874, also suggested a hydrogen bond with the tyrosine hydroxyl.	Hydrogen	153-161	endothelin receptor type A	Homo sapiens	91-94
30686752-7	2019	Docking simulations also implied that 6 interacted with hMAO-A at Phe208 and with hMAO-B at Ile199 by carbon hydrogen bondings.	Hydrogen	109-117	monoamine oxidase A	Homo sapiens	56-62
10250470-2	1981	The NRC is amending its regulations to permit licensees greater leeway in disposing of liquid scintillation media and animal carcasses containing tracer levels of hydrogen-3 (tritium) or carbon-14.	Hydrogen	163-171	nuclear receptor coactivator 6	Homo sapiens	4-7
10250470-6	1981	The NRC is also amending its regulations to raise the annual limits for disposal of hydrogen-3 and carbon-14 by release to the sanitary sewerage systems.	Hydrogen	84-92	nuclear receptor coactivator 6	Homo sapiens	4-7
8549805-1	1996	Glutaredoxin (Grx) (12 kDa) is a hydrogen donor for ribonucleotide reductase and also a general GSH-disulfide reductase of importance for redox regulation.	Hydrogen	33-41	glutaredoxin	Homo sapiens	0-12
6783072-0	1981	Hydrogen exchange analysis of ligand-induced conformational changes in Fab.	Hydrogen	0-8	FA complementation group B	Homo sapiens	71-74
30785438-5	2019	Consequently, the optimized CdS-ZnM-ZIF samples with Cu, Ni, and Co doping showed corresponding photocatalytic hydrogen activities 44, 92, and 59 times larger than that of pristine CdS nanorods.	Hydrogen	111-119	CDP-diacylglycerol synthase 1	Homo sapiens	28-31
30785438-5	2019	Consequently, the optimized CdS-ZnM-ZIF samples with Cu, Ni, and Co doping showed corresponding photocatalytic hydrogen activities 44, 92, and 59 times larger than that of pristine CdS nanorods.	Hydrogen	111-119	CDP-diacylglycerol synthase 1	Homo sapiens	181-184
30726070-3	2019	The proposed three-step catalytic cycle with Cp2 MCl L catalyst ( M = Ti, Zr; L = select organic ligands) requires the regeneration of nBuLi from Li(s), butene, and H2.	Hydrogen	165-167	ceruloplasmin	Homo sapiens	45-48
8549805-1	1996	Glutaredoxin (Grx) (12 kDa) is a hydrogen donor for ribonucleotide reductase and also a general GSH-disulfide reductase of importance for redox regulation.	Hydrogen	33-41	glutaredoxin	Homo sapiens	14-17
6283492-5	1981	We have, together with A. Holmgren and A. Ehrnberg, made observations suggesting the presence in rate liver cytosol of an enzyme which catalyzes the reductive reactivation of oxidized CCK with reduced thioredoxin as the immediate hydrogen donor.	Hydrogen	230-238	thioredoxin	Homo sapiens	201-212
8549805-4	1996	The recombinant human Grx in its reduced form was purified to homogenity with 50% yield and exhibited the same dehydroascorbate reductase and hydrogen donor activity for ribonucleotide reductase (Km approximately 0.2 microM) as the human placenta protein.	Hydrogen	142-150	glutaredoxin	Homo sapiens	22-25
30833722-5	2019	Crystal structures of murine IRE1 in complex with covalently bound hydroxyl aryl aldehyde (HAA) inhibitors show that these molecules form hydrophobic interactions with His910 and Phe889, a hydrogen bond with Tyr892 and an indispensable Schiff-base with Lys907.	Hydrogen	189-197	endoplasmic reticulum (ER) to nucleus signalling 2	Mus musculus	29-33
8723315-0	1996	Lac repressor-operator interaction: N-terminal peptide backbone 1H and 15N chemical shifts upon complex formation with DNA.	Hydrogen	64-66	lactase	Homo sapiens	0-3
29493425-5	2019	After screening and analysis, the 6 most promising PAD4 inhibitors are suggested, with strong interactions (pi-stacking, hydrogen bonds, hydrophobic contacts) and suitable pharmacotherapeutic profile as well.	Hydrogen	121-129	peptidyl arginine deiminase 4	Homo sapiens	51-55
6244857-6	1980	Space-filling models revealed the possibility of a hydrogen bond between the oxygen of amide of residue-70 asparagine and the epsilon-amino nitrogen of residue-72 lysine in unmethylated horse heart cytochrome C.	Hydrogen	51-59	cytochrome c, somatic	Equus caballus	198-210
8723315-4	1996	We isolated uniformly 15N labeled 56 amino acid wild-type (HP56WT) and 64 residue mutant [Pro3 &gt; Tyr3] (HP64tyr3) lac repressor N-terminal DNA binding fragments for 1H/15N NMR studies with the left and right operators separately.	Hydrogen	168-170	lactase	Homo sapiens	117-120
30194583-0	2019	Hydrogen bond-linked pathways of peptide units and polar groups of amino acid residues suitable for electron transfer in cytochrome c proteins.	Hydrogen	0-8	cytochrome c, somatic	Equus caballus	121-133
30194583-4	2019	Crystal structures of cytochrome c proteins from horse (1HRC), tuna (3CYT), rice (1CCR), and yeast (3CX5) were analyzed using pymol software for "Hydrogen Bonds" marking the polar atoms within the distance of 2.6-3.3 A and tracing the atom-to-atom pathways linked by hydrogen bonds.	Hydrogen	146-154	cytochrome c, somatic	Equus caballus	22-34
8819977-4	1995	Two water molecules formed hydrogen bond bridges between beta2 and beta3, in agreement with X-ray crystallographic data and a recent reassessment of the solution structure using time-averaged NMR restraints during MD refinement.	Hydrogen	27-35	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	57-72
30194583-4	2019	Crystal structures of cytochrome c proteins from horse (1HRC), tuna (3CYT), rice (1CCR), and yeast (3CX5) were analyzed using pymol software for "Hydrogen Bonds" marking the polar atoms within the distance of 2.6-3.3 A and tracing the atom-to-atom pathways linked by hydrogen bonds.	Hydrogen	267-275	cytochrome c, somatic	Equus caballus	22-34
7447647-7	1980	On the basis of theoretical possibilities a hypothetical model of the role of C-5 halogen substituent in complementary hydrogen bonds with the purines of DNA has been proposed.	Hydrogen	119-127	complement C5	Homo sapiens	78-81
7473721-2	1995	For example, an alanine residue at H71 provides room for packing CDR2/CDR1 and lysine residues at H73 and H93 contribute a salt-bridge to aspartic acid at H55 in CDR2 and a hydrogen bond to the carbonyl group at H96 in CDR3, respectively.	Hydrogen	173-181	cerebellar degeneration related protein 2	Homo sapiens	65-69
116677-6	1979	On the basis of these studies, it is suggested that hydrogen bonding occurs between the hydrogen atoms of the C-3 and C-4 hydroxyl groups of alpha-D-GalNAcp and alpha-D-galp units and the A and B subunits, respectively.	Hydrogen	52-60	complement C4A (Rodgers blood group)	Homo sapiens	118-121
116677-6	1979	On the basis of these studies, it is suggested that hydrogen bonding occurs between the hydrogen atoms of the C-3 and C-4 hydroxyl groups of alpha-D-GalNAcp and alpha-D-galp units and the A and B subunits, respectively.	Hydrogen	88-96	complement C4A (Rodgers blood group)	Homo sapiens	118-121
30694296-0	2019	A flexible CdS nanorods-carbon nanotubes/stainless steel mesh photoanode for boosted photoelectrocatalytic hydrogen evolution.	Hydrogen	107-115	CDP-diacylglycerol synthase 1	Homo sapiens	11-14
30694296-1	2019	An innovative flexible reticular photoanode (CdS-nanorods/CNTs coated on stainless iron mesh) was designed for efficiently driving photoelectrocatalytic (PEC) hydrogen (H2) evolution under visible-light irradiation.	Hydrogen	159-167	CDP-diacylglycerol synthase 1	Homo sapiens	45-48
30694296-1	2019	An innovative flexible reticular photoanode (CdS-nanorods/CNTs coated on stainless iron mesh) was designed for efficiently driving photoelectrocatalytic (PEC) hydrogen (H2) evolution under visible-light irradiation.	Hydrogen	169-171	CDP-diacylglycerol synthase 1	Homo sapiens	45-48
7473721-2	1995	For example, an alanine residue at H71 provides room for packing CDR2/CDR1 and lysine residues at H73 and H93 contribute a salt-bridge to aspartic acid at H55 in CDR2 and a hydrogen bond to the carbonyl group at H96 in CDR3, respectively.	Hydrogen	173-181	cerebellar degeneration related protein 2	Homo sapiens	162-166
30816277-6	2019	The hydrogen bond and binding free energy calculations explain that PAM recognition introduces more specific interactions to increase the cleavage activity of Cas1.	Hydrogen	4-12	BCAR1 scaffold protein, Cas family member	Homo sapiens	159-163
7473721-2	1995	For example, an alanine residue at H71 provides room for packing CDR2/CDR1 and lysine residues at H73 and H93 contribute a salt-bridge to aspartic acid at H55 in CDR2 and a hydrogen bond to the carbonyl group at H96 in CDR3, respectively.	Hydrogen	173-181	CDR3	Homo sapiens	219-223
447726-1	1979	The reaction of tryptamine with indolyl-3-alkane alpha-hydroxylase is shown to remove stereospecifically the pro-S hydrogen at C-2 of the side chain and to give hydroxytryptamine of "R" configuration.	Hydrogen	115-123	complement C2	Homo sapiens	127-130
9980254-0	1995	Hydrogen-adsorption-induced phase transitions on Pt(100)-hex and the surface structure of Pt(100)-(1 x 1)H.	Hydrogen	0-8	hematopoietically expressed homeobox	Homo sapiens	57-60
447726-5	1979	The hydrogens at C-1 of the tryptamine side chain and the alpha-hydrogen of L-tryptophan methyl ester are shown to be retained in the reactions.	Hydrogen	4-13	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	17-20
447726-5	1979	The hydrogens at C-1 of the tryptamine side chain and the alpha-hydrogen of L-tryptophan methyl ester are shown to be retained in the reactions.	Hydrogen	4-12	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	17-20
30720816-0	2019	Construction of CdS/MoS2 heterojunction from core-shell MoS2@Cd-MOF for efficient photocatalytic hydrogen evolution.	Hydrogen	97-105	CDP-diacylglycerol synthase 1	Homo sapiens	16-19
30720816-5	2019	Consequently, the CdS/MoS2 heterojunction exhibited a significantly enhanced photocatalytic H2 evolution rate of average 5587 mumol h-1 g-1 under UV-visible light irradiation.	Hydrogen	92-94	CDP-diacylglycerol synthase 1	Homo sapiens	18-21
7669770-4	1995	The greater affinity of CRBP for all-trans-retinol has been attributed to the presence of an amino-aromatic hydrogen bond, which is absent in CRBP(II).	Hydrogen	108-116	retinol binding protein 1	Homo sapiens	24-28
30488654-1	2019	N-Heterocyclic carbenes (NHCs, :C) can interact with azolium salts (C-H+ ) by either forming a hydrogen-bonded aggregate (CHC+ ) or a covalent C-C bond (CCH+ ).	Hydrogen	95-103	clathrin heavy chain	Homo sapiens	122-126
503871-2	1979	Carbon 11-labeled HCN was collected in methanol containing carrier NaCN following bombardment of 99% N2-1% H2 with 22 MeV protons.	Hydrogen	107-109	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	18-21
436824-8	1979	In particular intermolecular hydrogen bonds between these groups are postulated in the case of the bis(C32-erythro-mycoloyl)-trehalose.	Hydrogen	29-37	chemokine like factor	Homo sapiens	103-106
30638312-2	2019	The Pt-TNCB exhibits an excellent solar-driven photocatalytic hydrogen evolution rate (337.84 mumol h-1 ), which is about 37 times higher than that of TNCB (9.19 mumol h-1 ).	Hydrogen	62-70	H1.5 linker histone, cluster member	Homo sapiens	100-103
8746730-2	1995	The activation energies calculated for these reactions clearly showed that hydrogen transfer is the rate-determining step of the enzymatic isomerization and that Mg2+ ions activate whereas Zn2+ ions inhibit the reaction, in agreement with the experiments.	Hydrogen	75-83	mucin 7, secreted	Homo sapiens	162-165
30475996-7	2019	The potential direct cardiovascular benefits of SGLT2 inhibitors include: augmentation of signal transducer and activator of transcription 3; inhibition of sodium hydrogen exchange; reduction of atherosclerosis; modulation of natriuretic peptides; vasodilation; modulation of sympathetic tone; and reduction of inflammation, oxidative stress, endoplasmic reticulum stress, and cardiac glucose uptake via down-regulation of SGLT1 expression.	Hydrogen	163-171	solute carrier family 5 member 2	Homo sapiens	48-53
8527674-8	1995	The sites that dominate relaxation-and produce contrast in magnetic resonance imaging (MRI), which derives from 1/T1 and 1/T2 of tissue water protons-have tau M approximately 10(-6)s. These, which involve four hydrogen bonds, occupy &lt; or = 1% of the protein-water interface.	Hydrogen	210-218	interleukin 1 receptor like 1	Homo sapiens	114-122
7626622-6	1995	The conserved sequence contains a tyrosine residue (Tyr-44) which, based on the X-ray crystal structure of ferredoxin-NADP+ reductase, is postulated to participate in FAD binding through van der Waals contact with the isoalloxazine ring and a hydrogen bond to the 3"-hydroxy of the ribityl moiety.	Hydrogen	243-251	ferredoxin reductase	Homo sapiens	107-133
30365987-4	2019	The peptides were subjected to molecular docking on human DPP-IV where the binding free energies were PFP &lt; YPG &lt; YPL &lt; diprotin A while hydrogen bond interactions were critical in the binding of YPL and YPG.	Hydrogen	146-154	dipeptidyl peptidase 4	Homo sapiens	58-64
42281-2	1979	It has been shown that the transport carrier in astrocytes is stereospecific for the C-4 hydrogens of the GABA molecule and that its structural requirements are distinct from those exhibited by the neuronal GABA carrier.	Hydrogen	89-98	complement C4A (Rodgers blood group)	Homo sapiens	85-88
364062-4	1978	These results support the concept of an important interaction between the ends of the LH-RH molecule possibly involving hydrogen-bond formation between the pyrrolidone carbonyl group of pyroglutamic acid and the glycinamide group.	Hydrogen	120-128	gonadotropin releasing hormone 1	Rattus norvegicus	86-91
7635144-15	1995	The full-length coding region of GlcNAc-T II has been expressed in the baculovirus/Sf9 insect cell system, the recombinant enzyme has been purified to near homogeneity with a specific activity of about 20 mumol.min-1.mg-1 and the product synthesized by the recombinant enzyme has been identified by high-resolution 1H-NMR spectroscopy and mass spectrometry.	Hydrogen	315-317	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Rattus norvegicus	33-44
151865-2	1978	The nucleoside triphosphates (NTPs) with an amino group at the 6 position and hydrogen at the 8 position, and formycin 5"-triphosphate (FTP) were hydrolyzed by myosin very slowly in the presence of Mg2+ and rapidly in the presence of EDTA and K+.	Hydrogen	78-86	myosin heavy chain 14	Homo sapiens	160-166
29697952-2	2019	In this work, graphdiyne (GD) was first introduced to the visible-light catalytic system for hydrogen production, in which a CdS/GD heterojunction was prepared through a simple in situ growth process by adding Cd(AcO)2 into a dimethyl sulfoxide (DMSO) solution containing GD substrate.	Hydrogen	93-101	CDP-diacylglycerol synthase 1	Homo sapiens	125-128
29697952-3	2019	The as-prepared CdS/GD heterojunction exhibits much higher performance for photocatalytic hydrogen evolution compared to that of pristine GD and CdS nanoparticles.	Hydrogen	90-98	CDP-diacylglycerol synthase 1	Homo sapiens	16-19
7733652-1	1995	Addition of HS- enhanced the O(2-)-scavenging activity of bovine erythrocyte Cu,Zn superoxide dismutase (EC 1.15.1.1) by about twofold.	Hydrogen	12-14	superoxide dismutase [Cu-Zn]	Bos taurus	77-103
30565612-8	2019	According to molecular docking, the strong interaction between condensed tannins and tyrosinase was mainly driven by hydrogen bonding and hydrophobic force.	Hydrogen	117-125	tyrosinase	Mus musculus	85-95
30788005-0	2019	Postconditioning with inhaled hydrogen attenuates skin ischemia/reperfusion injury through the RIP-MLKL-PGAM5/Drp1 necrotic pathway.	Hydrogen	30-38	collapsin response mediator protein 1	Rattus norvegicus	110-114
699918-6	1978	Upon illumination of rhodopsin (bleaching) in the presence of detergents, the hydrogen exchange rates are greatly increased and shifts in the amide I band frequencies are observed, indicative of a large conformation change.	Hydrogen	78-86	rhodopsin	Bos taurus	21-30
7876221-8	1995	One-dimensional 1H and two-dimensional 15N-1H shift correlation NMR spectra of myristoylated recoverin measured as a function of Ca2+ concentration show that a concerted conformational change occurs when two Ca2+ are bound.	Hydrogen	43-45	recoverin	Homo sapiens	93-102
687577-5	1978	From the comparison of the association constants (deduced from fluorescence measurements) for the binding of Fab fragments to several polynucleotides, a direct interaction between atoms or groups of the bases, which can be involved in hydrogen bonds, can be excluded.	Hydrogen	235-243	FA complementation group B	Homo sapiens	109-112
671267-2	1978	The hydrogen atom attached to C-5 is in the alpha-configuration.	Hydrogen	4-12	complement C5	Homo sapiens	30-33
680727-6	1978	The failure of dealkylative nitrosation reactions in the latter tetracyclines is explained by the formation of intramolecular hydrogen bridge linkages between epidimethylamino groups at C-4 and OH groups at C-6.	Hydrogen	126-134	complement C4A (Rodgers blood group)	Homo sapiens	186-189
201319-6	1977	The observed configurational specificity was compared with the stringency that would be predicted to occur if enkephalin adopted certain hydrogen-bonded conformations at the receptor.	Hydrogen	137-145	proenkephalin	Rattus norvegicus	110-120
196853-2	1977	The ethanols were administered to female bile fistula rats for 10 h. The hydrogen at C-2 in the glycerol moiety of newly formed phosphatidylcholine molecules in bile, liver and plasma was derived to 22-25% from the 1-pro-R position and to 5-6% from the 1-pro-S position in the ethanol.	Hydrogen	73-81	complement C2	Rattus norvegicus	85-88
820337-1	1976	Loss of C-5 hydrogen during conversion of D-glucuronic to L-iduronic acid residues.	Hydrogen	12-20	complement C5	Homo sapiens	8-11
1083847-9	1976	Each product can be assigned a precursor radical formed by hydrogen abstraction from C-5, C-4 or C-3 of the ribose-5-phosphate molecule.	Hydrogen	59-67	complement C5	Homo sapiens	85-88
1083847-9	1976	Each product can be assigned a precursor radical formed by hydrogen abstraction from C-5, C-4 or C-3 of the ribose-5-phosphate molecule.	Hydrogen	59-67	complement C4A (Rodgers blood group)	Homo sapiens	90-93
3870-3	1976	High positive correlation existed between changes in CSF hydrogen ion concentration and pial arteriolar diameter, suggesting metabolic regulation of CBF through CSF/interstitial fluid hydrogen ion alterations during the seizure.	Hydrogen	57-65	colony stimulating factor 2	Homo sapiens	53-56
3870-3	1976	High positive correlation existed between changes in CSF hydrogen ion concentration and pial arteriolar diameter, suggesting metabolic regulation of CBF through CSF/interstitial fluid hydrogen ion alterations during the seizure.	Hydrogen	57-65	colony stimulating factor 2	Homo sapiens	161-164
3870-3	1976	High positive correlation existed between changes in CSF hydrogen ion concentration and pial arteriolar diameter, suggesting metabolic regulation of CBF through CSF/interstitial fluid hydrogen ion alterations during the seizure.	Hydrogen	184-192	colony stimulating factor 2	Homo sapiens	53-56
4154902-0	1974	[The slow dissociation of the NADH-dehydrogenase complex as a basis for the preferential transfer of hydrogen between the C-17 positions of steroids (author"s transl)].	Hydrogen	37-45	cytokine like 1	Homo sapiens	122-126
4722437-4	1973	The relative inhibition constants of d-glucose and its deoxy, epimeric and fluorinated analogues are consistent with the combination of beta-d-glucopyranose with the carrier by hydrogen bonds at C-1, C-3, probably C-4, and possibly C-6 of the sugar.	Hydrogen	177-185	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	195-203
4722437-4	1973	The relative inhibition constants of d-glucose and its deoxy, epimeric and fluorinated analogues are consistent with the combination of beta-d-glucopyranose with the carrier by hydrogen bonds at C-1, C-3, probably C-4, and possibly C-6 of the sugar.	Hydrogen	177-185	complement C4A (Rodgers blood group)	Homo sapiens	214-217
4655423-2	1972	The four diols resulting from replacement of the hydroxy groups at C-1 or C-2 of sn-glycerol by fluorine or hydrogen are weak substrates.	Hydrogen	108-116	complement C2	Homo sapiens	74-77
4392239-6	1970	The kinetics of type I reactions with EDTA, dl-alpha-phenylglycine and diethanolamine are all consistent with a mechanism in which the rate-determining step, hydrogen abstraction by the FMN triplet, is followed by rapid reoxidation of reduced FMN by oxygen.	Hydrogen	158-166	formin 1	Homo sapiens	186-189
4392239-6	1970	The kinetics of type I reactions with EDTA, dl-alpha-phenylglycine and diethanolamine are all consistent with a mechanism in which the rate-determining step, hydrogen abstraction by the FMN triplet, is followed by rapid reoxidation of reduced FMN by oxygen.	Hydrogen	158-166	formin 1	Homo sapiens	243-246
22442846-5	1969	SAT is the equilibrium constant for the formation of a hydrogen-bonded AT base pair from a pair of unbonded bases at the junction between a helical region and a denatured region and SGC is the like constant for the formation of a GC base pair.	Hydrogen	55-63	Dopamine transporter	Drosophila melanogaster	1-3
22442846-5	1969	SAT is the equilibrium constant for the formation of a hydrogen-bonded AT base pair from a pair of unbonded bases at the junction between a helical region and a denatured region and SGC is the like constant for the formation of a GC base pair.	Hydrogen	55-63	Dopamine transporter	Drosophila melanogaster	44-46
6033545-7	1967	The precise site of action is assumed to involve hydrogen bonds, resulting in configurational changes in nucleolar RNP and affecting the stability of the DNA molecule.	Hydrogen	49-57	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	115-118
13721807-0	1961	Catalysis of an inorganic phosphate-H2-O-18 exchange by actomysin and myosin.	Hydrogen	36-38	myosin heavy chain 14	Homo sapiens	70-76
33831832-5	2021	Moreover, MRLC phosphorylation at Ser17 was beneficial to the formation of ionic bonds, hydrogen bonds, and hydrophobic interaction between myosin and actin, and was the second possible way that MRLC phosphorylation at Ser17 negatively affects actomyosin dissociation.	Hydrogen	88-96	myosin heavy chain 14	Homo sapiens	140-146
34047278-1	2021	We report on an investigation of the temperature-dependent ordering of the hydrogen/deuterium atoms in geometrically frustrated magnets Co2(OH)3Br and its deuterated Co2(OD)3Br, to shed light on the origin of the newly-identified ferroelectricity using Raman spectroscopy.	Hydrogen	75-83	complement C2	Homo sapiens	136-146
34047278-1	2021	We report on an investigation of the temperature-dependent ordering of the hydrogen/deuterium atoms in geometrically frustrated magnets Co2(OH)3Br and its deuterated Co2(OD)3Br, to shed light on the origin of the newly-identified ferroelectricity using Raman spectroscopy.	Hydrogen	75-83	complement C2	Homo sapiens	166-176
34014684-5	2021	We illustrate the application of our new hybrid scheme by computing the influence of intramolecular hydrogen-bonding interactions in two small molecules: 1,6-(tG+G+TG+G+g-)-hexanediol and a cyclic analogue, cis-1,4-cyclohexanediol.	Hydrogen	100-108	suppressor of cytokine signaling 1	Homo sapiens	207-212
34052536-0	2021	A novel worm-like micelles@MOFs precursor for constructing hierarchically porous CoP/N-doped carbon networks towards efficient hydrogen evolution reaction.	Hydrogen	127-135	caspase recruitment domain family member 16	Homo sapiens	81-84
33975155-4	2021	Recently, deeper insights into the mechanism underlying stepwise conformational changes during GPCR-G protein coupling were obtained using hydrogen/deuterium exchange mass spectrometry, hydroxyl radical footprinting-mass spectrometry, X-ray crystallography, cryoelectron microscopy, and molecular dynamics simulation techniques.	Hydrogen	139-147	C-X-C motif chemokine receptor 6	Homo sapiens	95-99
33792090-3	2021	The Pt1 /NMHCS composite is much more active and stable than the nanoparticle (PtNP ) counterpart and commercial 20 wt% Pt/C for catalyzing the electrocatalytic hydrogen evolution reaction (HER), exhibiting a low overpotential of 40 mV at a current density of 10 mA cm-2 , a high mass activity of 2.07 A mg-1 Pt at 50 mV overpotential, a large turnover frequency of 20.18 s-1 at 300 mV overpotential, and outstanding durability in acidic electrolyte.	Hydrogen	161-169	zinc finger protein 77	Homo sapiens	4-7
31459327-2	2019	Here, MP2 calculations with aug-cc-pVDZ basis set (aug-cc-pVDZ-pp for element Sn) were used to optimize the geometric configurations of the hydrogen-bonded complexes MH3F   HCN (M = C, Si, Ge, and Sn), carbon-bonded complexes HCN   MH3F (M = C, Si, Ge, and Sn), and transition states; the conversion mechanism between these two types of interactions has been carried out.	Hydrogen	140-148	tryptase pseudogene 1	Homo sapiens	6-9
31459327-2	2019	Here, MP2 calculations with aug-cc-pVDZ basis set (aug-cc-pVDZ-pp for element Sn) were used to optimize the geometric configurations of the hydrogen-bonded complexes MH3F   HCN (M = C, Si, Ge, and Sn), carbon-bonded complexes HCN   MH3F (M = C, Si, Ge, and Sn), and transition states; the conversion mechanism between these two types of interactions has been carried out.	Hydrogen	140-148	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	173-176
31459327-2	2019	Here, MP2 calculations with aug-cc-pVDZ basis set (aug-cc-pVDZ-pp for element Sn) were used to optimize the geometric configurations of the hydrogen-bonded complexes MH3F   HCN (M = C, Si, Ge, and Sn), carbon-bonded complexes HCN   MH3F (M = C, Si, Ge, and Sn), and transition states; the conversion mechanism between these two types of interactions has been carried out.	Hydrogen	140-148	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	226-229
30420425-7	2019	Hydrogen-deuterium exchange MS-mediated interrogation of the intrinsic dynamics of these enzymes suggested the presence of a substrate-binding platform encompassed by the NTD and the 240"s region (containing residues 236-246), which serves as a general exosite for caspase-6-specific substrate recruitment.	Hydrogen	0-8	caspase 6	Homo sapiens	265-274
30604743-3	2019	The structures reveal the detailed interactions between clinically approved antagonists and NK1R, which induce a distinct receptor conformation resulting in an interhelical hydrogen-bond network that cross-links the extracellular ends of helices V and VI.	Hydrogen	173-181	tachykinin receptor 1	Homo sapiens	92-96
30798936-11	2019	From the simulation studies, we observed higher deviation, lower protein compactness, and a decrease in the number of intramolecular hydrogen bonds in the mutant W764C MSH2-MSH6 protein complex.	Hydrogen	133-141	mutS homolog 6	Homo sapiens	173-177
30261305-6	2019	During mild SI, H2 reduced plasma surges of proinflammatory cytokines (TNF-alpha and IL-6) while caused an increase in plasma IL-10 (anti-inflammatory cytokine) and prevented fever.	Hydrogen	16-18	interleukin 10	Rattus norvegicus	126-131
30261305-8	2019	Moreover, H2 caused a reduction in surges of proinflammatory cytokines (plasma TNF-alpha and IL-1beta) and prostaglandin E2 [(PGE2), in plasma and hypothalamus], and an increase in plasma IL-10.	Hydrogen	10-12	interleukin 10	Rattus norvegicus	188-193
30521326-0	2018	Phytic Acid-Assisted Formation of Hierarchical Porous CoP/C Nanoboxes for Enhanced Lithium Storage and Hydrogen Generation.	Hydrogen	103-111	caspase recruitment domain family member 16	Homo sapiens	54-57
30521326-6	2018	Moreover, when used as an electrocatalyst for hydrogen evolution reaction, the CoP/C nanoboxes exhibit ultralow overpotential, small Tafel slope, and excellent durability in acidic media.	Hydrogen	46-54	caspase recruitment domain family member 16	Homo sapiens	79-82
30733623-2	2018	Although Cp2Ti(H)Cl has generally been regarded as a robust species, its decomposition to Cp2TiCl and molecular hydrogen was found to be exothermic (DeltaG = -11 kcal/mol when the effects of THF solvation are considered).	Hydrogen	112-120	ceruloplasmin	Homo sapiens	9-12
30733623-7	2018	Under the conditions of protic catalysis, Cp2TiCl complexes with collidine hydrochloride and the titanium(III) center is less available for "cross-disproportionation" with carbon-centered radicals; this leads to by-products from radical capture by hydrogen atom transfer, resulting in a saturated alcohol.	Hydrogen	248-256	ceruloplasmin	Homo sapiens	42-45
30353987-0	2018	Integration of Lanthanide-Transition-Metal Clusters onto CdS Surfaces for Photocatalytic Hydrogen Evolution.	Hydrogen	89-97	CDP-diacylglycerol synthase 1	Homo sapiens	57-60
30353987-2	2018	Herein, we present a strategy for enhanced hydrogen evolution by loading atomically precise 4f-3d clusters Ln52 Ni56 on a CdS photoabsorber surface.	Hydrogen	43-51	CDP-diacylglycerol synthase 1	Homo sapiens	122-125
30353987-4	2018	Photocatalytic studies show that the efficient synergistic multipath charge separation and transfer from CdS to the Eu52 Ni56-x Cdx cluster enable high visible-light-driven hydrogen evolution at 25 353 mumol h-1  g-1 .	Hydrogen	173-181	CDP-diacylglycerol synthase 1	Homo sapiens	105-108
30591849-3	2018	A hydrogen-induced phase transition from PdHbeta to PdHalpha is found to enable internal-stress plasticity (or transformation-mismatch plasticity) in nanoporous palladium, which leads to exceptionally high strains without fracture as a result of external forces.	Hydrogen	2-10	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	52-60
30284486-5	2018	Docking studies revealed that compound 6a can be accommodated into BuChE via five hydrogen bonds, one Pi-Sigma interaction and three Pi-Alkyl interactions.	Hydrogen	82-90	butyrylcholinesterase	Homo sapiens	67-72
29980846-6	2018	The phosphorylation of cytoplasmic MKK4 and JNK were enhanced in the NT group and suppressed in the H2 group.	Hydrogen	100-102	mitogen-activated protein kinase 8	Rattus norvegicus	44-47
29980846-8	2018	CONCLUSION: H2 was observed to ameliorate IRI in the DCD liver by maintaining microcirculation, mitochondrial functions, and redox status, as well as suppressing the cytoplasmic MKK4-JNK-mediated cellular death pathway.	Hydrogen	12-14	mitogen-activated protein kinase 8	Rattus norvegicus	183-186
30546478-5	2018	The participation of the out-inverted and protonated 1-NMe2 group in the Me2N-H   NH=C hydrogen bond is experimentally demonstrated.	Hydrogen	87-95	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	55-59
30372619-6	2018	Exposure of CIR+ cells to GFP-PFCs resulted in highly specific binding and internalization as confirmed by fluorescence microscopy as well as flow cytometry and enabled visualization by 1H/19F MRI.	Hydrogen	186-188	circling	Mus musculus	12-15
30466274-3	2018	The IRPD spectrum is consistent with a planar, singly hydrogen-bonded structure according to an MP2 and CCSD(T) anharmonic analysis via generalized second-order vibrational perturbation theory.	Hydrogen	54-62	tryptase pseudogene 1	Homo sapiens	96-99
29906119-4	2018	Using well-calibrated methods, we have determined the preferred hydrogen-bonding partners of Cys- bound to native Zn2+ or xenobiotic Cd2+ in Zn-fingers of varying net charge and solvent accessibility as well as the key factors underlying the observed preference.	Hydrogen	64-72	CD2 molecule	Homo sapiens	133-136
29906119-5	2018	We show how secondary hydrogen-bonding interactions with metal-bound thiolates might exert a significant impact on Zn2+ Cd2+ substitution and thus protein function.	Hydrogen	22-30	CD2 molecule	Homo sapiens	120-123
30320326-3	2018	The as-prepared CdS NPs/CTF-1 assembly showed higher photocatalytic activity in a hydrogen evolution reaction under visible light irradiation as compared with pure CdS and CTF-1 and their physical mixture.	Hydrogen	82-90	CDP-diacylglycerol synthase 1	Homo sapiens	16-19
30320326-3	2018	The as-prepared CdS NPs/CTF-1 assembly showed higher photocatalytic activity in a hydrogen evolution reaction under visible light irradiation as compared with pure CdS and CTF-1 and their physical mixture.	Hydrogen	82-90	cardiotrophin 1	Homo sapiens	24-29
30324954-0	2018	Largely enhanced photocatalytic hydrogen production rate of CdS/(Au-ReS2) nanospheres by the dielectric-plasmon hybrid antenna effect.	Hydrogen	32-40	CDP-diacylglycerol synthase 1	Homo sapiens	60-63
30324954-1	2018	In this study, we synthesized CdS/(Au-ReS2) nanospheres that have highly efficient photocatalytic hydrogen production activity induced by dielectric-plasmon hybrid antenna resonance.	Hydrogen	98-106	CDP-diacylglycerol synthase 1	Homo sapiens	30-33
30324954-3	2018	Due to the enhancements of the local electromagnetic field and excitation energy transfer by the ReS2-Au dielectric-plasmon hybrid antenna, the hydrogen production rate for the CdS/(Au-ReS2) nanospheres (D = 218 +- 25 nm) is 797, 319, 105 and 12 times larger than that for pure ReS2, Au-ReS2, CdS, and CdS-ReS2, respectively.	Hydrogen	144-152	CDP-diacylglycerol synthase 1	Homo sapiens	177-180
30324954-3	2018	Due to the enhancements of the local electromagnetic field and excitation energy transfer by the ReS2-Au dielectric-plasmon hybrid antenna, the hydrogen production rate for the CdS/(Au-ReS2) nanospheres (D = 218 +- 25 nm) is 797, 319, 105 and 12 times larger than that for pure ReS2, Au-ReS2, CdS, and CdS-ReS2, respectively.	Hydrogen	144-152	CDP-diacylglycerol synthase 1	Homo sapiens	293-296
30324954-3	2018	Due to the enhancements of the local electromagnetic field and excitation energy transfer by the ReS2-Au dielectric-plasmon hybrid antenna, the hydrogen production rate for the CdS/(Au-ReS2) nanospheres (D = 218 +- 25 nm) is 797, 319, 105 and 12 times larger than that for pure ReS2, Au-ReS2, CdS, and CdS-ReS2, respectively.	Hydrogen	144-152	CDP-diacylglycerol synthase 1	Homo sapiens	293-296
30290280-7	2018	ROS quantification of these compounds showed oxidative stress to cancerous cells and molecular docking study showed hydrogen bonding, charge or polar and van der Waals interactions with the active site residues of MARK4.	Hydrogen	116-124	microtubule affinity regulating kinase 4	Homo sapiens	214-219
33879035-7	2021	Our analysis showed that NAPQI and NAC, but not acetaminophen, bind strongly to the similar sites in hVKOR via both hydrogen and van der Waals bonding; particularly with Cys135.	Hydrogen	116-124	vitamin K epoxide reductase complex subunit 1	Homo sapiens	101-106
33874887-0	2021	Pre-inhalation of hydrogen-rich gases protect against caerulein-induced mouse acute pancreatitis while enhance the pancreatic Hsp60 protein expression.	Hydrogen	18-26	heat shock protein 1 (chaperonin)	Mus musculus	126-131
33874887-11	2021	RESULTS: The pancreatic pathological changes, plasma amylase and lipase activity, and the increase of plasma IL-1 and IL-6 levels in AP mice were significantly improved by the hydrogen-rich gases pretreatment, Meanwhile, the pancreatic GSH content increased and the pancreatic MDA content decreased.	Hydrogen	176-184	lipase, endothelial	Mus musculus	65-71
33577818-5	2021	After compositing with polyvinyl alcohol (PVA) matrix, Lig-Ag NPs provided strong sacrificial hydrogen bonds and facilitated the delivery of electronic.	Hydrogen	94-102	ubiquitin conjugating enzyme E2 K	Homo sapiens	55-58
33921209-8	2021	GLP-1 and gastrin decrease the expression of Na+-K+/ATPase and increase the phosphorylation of sodium/hydrogen exchanger type 3 (NHE3) in human renal proximal tubule cells (hRPTCs).	Hydrogen	102-110	gastrin	Homo sapiens	10-17
7900835-3	1995	The kidney H(+)-K(+)-ATPase protein(s) contribute to potassium reabsorption and secretion of hydrogen ions to maintain potassium and acid-base homeostasis.	Hydrogen	93-101	ATPase, H+/K+ exchanging, beta polypeptide	Mus musculus	11-27
33439102-10	2021	Sirt1 induction by molecular hydrogen via the HO-1/AMPK/PPARalpha/PPARgamma pathway suppresses palmitate-mediated abnormal fat metabolism.	Hydrogen	29-37	sirtuin 1	Mus musculus	0-5
7655189-0	1995	Sequence-specific 1H NMR assignments and secondary structure of a lipid-associating peptide from human ApoC-I: an NMR study of an amphipathic helix motif.	Hydrogen	18-20	apolipoprotein C1	Homo sapiens	103-109
33063293-2	2021	Here, we report on neurometabolic alterations in spinocerebellar ataxia type 1 (SCA1; SCA-ATXN1) and 14 (SCA14; SCA-PRKCG) assessed by non-invasive 1H magnetic resonance spectroscopy.	Hydrogen	148-150	protein kinase C gamma	Homo sapiens	105-110
33063293-13	2021	1H magnetic resonance spectroscopy revealed differing neurochemical profiles in SCA1 and SCA14 and confirmed metabolic changes that may be indicative for neuronal loss and dysfunctional energy metabolism.	Hydrogen	0-2	protein kinase C gamma	Homo sapiens	89-94
7851394-1	1995	Glutaredoxin is generally a glutathione-dependent hydrogen donor for ribonucleotide reductase and also catalyses general glutathione (GSH)-disulfide-oxidoreduction reactions in the presence of NADPH and glutathione reductase.	Hydrogen	50-58	glutaredoxin	Homo sapiens	0-12
33438321-5	2021	The Ru 1 CoP/CDs formed from doping atomic Ru dispersed on CoP showed very high efficiency for the hydrogen evolution reaction (HER) over a wide pH range.	Hydrogen	99-107	caspase recruitment domain family member 16	Homo sapiens	9-12
33438321-5	2021	The Ru 1 CoP/CDs formed from doping atomic Ru dispersed on CoP showed very high efficiency for the hydrogen evolution reaction (HER) over a wide pH range.	Hydrogen	99-107	caspase recruitment domain family member 16	Homo sapiens	59-62
7835432-1	1995	Platelet factor 4 (PF4), a protein of 70 residues, exists in solution as a distribution of monomer, dimer and tetramer (M-D-T) states in slow exchange on a 600 MHz 1H-NMR chemical shift time scale.	Hydrogen	164-166	platelet factor 4	Homo sapiens	0-17
33750980-12	2021	The SD1 were negatively correlated to soil pH, hydrogen (H+), potassium (K+) and carbon (C).	Hydrogen	47-55	CUP2Q35	Homo sapiens	4-7
7835432-1	1995	Platelet factor 4 (PF4), a protein of 70 residues, exists in solution as a distribution of monomer, dimer and tetramer (M-D-T) states in slow exchange on a 600 MHz 1H-NMR chemical shift time scale.	Hydrogen	164-166	platelet factor 4	Homo sapiens	19-22
8584672-3	1995	Both lysyl oxidase and SSAO catalyze the oxidation of tyramine with removal of the pro-S hydrogen from C-1 of this substrate.	Hydrogen	89-97	amine oxidase copper containing 3	Homo sapiens	23-27
33522067-6	2021	Our findings indicate that histone H4 tails engage in a fuzzy interaction with nucleosomal DNA, underpinned by a variable pattern of short-lived salt bridges and hydrogen bonds, which persists at low ionic strength (0-100 mM NaCl).	Hydrogen	162-170	H4 clustered histone 6	Homo sapiens	27-37
33548803-0	2021	Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach.	Hydrogen	134-142	G protein-coupled receptor 119	Homo sapiens	57-63
33548803-3	2021	We elucidated crucial roles of the methylsulfonyl group of 2 in its interaction with the hERG channel and the GPR119 receptor, presumably as a hydrogen bond acceptor (HBA).	Hydrogen	143-151	G protein-coupled receptor 119	Homo sapiens	110-116
8584672-4	1995	The copper amine oxidase enzymes that react with abstraction of the pro-S hydrogen from C-1 of substrates do not exhibit a solvent exchange pathway.	Hydrogen	74-82	amine oxidase copper containing 3	Homo sapiens	4-24
7803391-2	1994	The 1H NMR resonances of the methyl groups of TGF-alpha were used as probes of the interaction of TGF-alpha with the EGF receptor to determine the binding kinetics and the differential mobility within the bound TGF-alpha.	Hydrogen	4-6	transforming growth factor alpha	Homo sapiens	46-55
33576627-5	2021	TO-317 exhibits 158-fold selectivity for HDAC6 over other HDAC isozymes by binding the catalytic Zn2+ and, uniquely, making a never seen before direct hydrogen bond with the Zn2+ coordinating residue, His614.	Hydrogen	151-159	histone deacetylase 6	Danio rerio	41-46
33586743-0	2021	CdS/Ag2S/g-C3N4 ternary composites with superior photocatalytic performance for hydrogen evolution under visible light irradiation.	Hydrogen	80-88	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
33586743-3	2021	Compared with the pure samples and binary composites, CdS/Ag2S/g-C3N4 ternary composites showed enhanced hydrogen production activities, and the maximum hydrogen production rate of CdS/Ag2S(2%)/CN is about 1020.54 mumol g-1 h-1 in Na2S-Na2SO3 solution.	Hydrogen	105-113	CDP-diacylglycerol synthase 1	Homo sapiens	54-57
7803391-4	1994	Changes in the longitudinal and transverse 1H NMR relaxation rates of the methyl resonances of TGF-alpha caused by binding to the 85-kDa EGFR-ED were studied.	Hydrogen	43-45	transforming growth factor alpha	Homo sapiens	95-104
33586743-3	2021	Compared with the pure samples and binary composites, CdS/Ag2S/g-C3N4 ternary composites showed enhanced hydrogen production activities, and the maximum hydrogen production rate of CdS/Ag2S(2%)/CN is about 1020.54 mumol g-1 h-1 in Na2S-Na2SO3 solution.	Hydrogen	153-161	CDP-diacylglycerol synthase 1	Homo sapiens	54-57
33586743-3	2021	Compared with the pure samples and binary composites, CdS/Ag2S/g-C3N4 ternary composites showed enhanced hydrogen production activities, and the maximum hydrogen production rate of CdS/Ag2S(2%)/CN is about 1020.54 mumol g-1 h-1 in Na2S-Na2SO3 solution.	Hydrogen	153-161	CDP-diacylglycerol synthase 1	Homo sapiens	181-184
7995174-1	1994	It has been recently demonstrated that human esophageal submucosal mucous glands exhibit the ability to secrete copious amounts of mucin, well known within the gastrointestinal tract for its protective quality against hydrogen ion and pepsin.	Hydrogen	218-226	LOC100508689	Homo sapiens	131-136
33746753-11	2021	These data indicate that IL-1beta modulates GlyR activity by establishing hydrogen bonds with at least one key amino acid residue located in the back of the loop C at the ECD domain of the betaGlyR subunit.	Hydrogen	74-82	interleukin 1 alpha	Homo sapiens	25-33
7727060-10	1994	Further, the detailed interactions between UpA and RNase A are characterized in terms of hydrogen bonds and energetics.	Hydrogen	89-97	ribonuclease A family member 1, pancreatic	Homo sapiens	51-58
7696215-1	1994	The historical model for the agonistic binding site on the histamine H2-receptor is based on a postulated activation mechanism: it has been suggested that the histamine monocation binds to the histamine H2-receptor via the formation of three hydrogen bonds.	Hydrogen	242-250	histamine receptor H2	Homo sapiens	59-80
33191127-5	2021	Thermodynamic analysis and molecular docking further demonstrated that the inhibition of 4-hexylresorcinol on the alpha-glucosidase was mainly dependent on hydrogen bond and hydrophobic interaction.	Hydrogen	156-164	sucrase-isomaltase	Homo sapiens	114-131
30007881-10	2018	The thermodynamic signatures of this interaction reveals hydrogen bonding played a major role in the binding of alpha2M-tannic acid.	Hydrogen	57-65	alpha-2-macroglobulin	Ovis aries	112-119
7812151-1	1994	Sequence-specific assignments for the 1H and 15N backbone resonances of cellular retinoic acid-binding protein (CRABP), with and without the bound ligand, have been obtained.	Hydrogen	38-40	cellular retinoic acid binding protein 1	Homo sapiens	112-117
7875941-3	1994	It is stabilized by a bifurcated hydrogen bond in which (Gly3)NH interacts with both (Gly1)CO and (hPro2)N alpha.	Hydrogen	33-41	threonine aldolase 1, pseudogene	Homo sapiens	86-90
29884374-8	2018	The thermodynamic parameters indicated that hydrogen bonding and Vander Waals forces played a key role in the LPO-ectoine interaction process.	Hydrogen	44-52	lactoperoxidase	Bos taurus	110-113
8089099-8	1994	The model places the binding pocket for TRH within the transmembrane domains of the receptor and predicts that multiple hydrogen-bonding interactions are involved in binding TRH.	Hydrogen	120-128	thyrotropin releasing hormone	Homo sapiens	40-43
30261723-4	2018	The 1,1-HCl and 1,1-HF reactions gave carbenes, CD2Cl(F)C: and CD2Cl(Cl)C:, respectively, as products, which have hydrogen-bonded complexes with HCl or HF in the exit channel of the potential energy surface.	Hydrogen	114-122	CD2 molecule	Homo sapiens	48-51
8089099-8	1994	The model places the binding pocket for TRH within the transmembrane domains of the receptor and predicts that multiple hydrogen-bonding interactions are involved in binding TRH.	Hydrogen	120-128	thyrotropin releasing hormone	Homo sapiens	174-177
33360738-2	2021	To this end, here we report systematic solution thermodynamic and solution structural study on the interaction of (eta5-Cp*)Rh(III) cation with histidine containing peptides and their constituents ((N-methyl)imidazole, GGA-OH, GGH-OH, histidine-amide, HGG-OH, GHG-NH2), based on extensive 1H NMR, ESI-MS and potentiometric investigations.	Hydrogen	289-291	ceruloplasmin	Homo sapiens	120-123
29957728-8	2018	Intramuscular MCP-1 was increased at 1H, 5H, and 48H in all groups.	Hydrogen	37-39	C-C motif chemokine ligand 2	Homo sapiens	14-19
8078898-9	1994	1H NMR data indicate that each of the single-mutant heme-Hx complexes is predominantly low-spin, perhaps owing to coordination of the heme iron by the Thr side-chain oxygen or water oxygen coordinating to the iron.	Hydrogen	0-2	hemopexin	Homo sapiens	57-59
29713947-0	2018	1H, 15N and 13C resonance assignments of the J-domain of co-chaperone Sis1 from Saccharomyces cerevisiae.	Hydrogen	0-2	type II HSP40 co-chaperone SIS1	Saccharomyces cerevisiae S288C	70-74
29713947-7	2018	This work reports the 1H, 15N and 13C resonance assignments of the J-domain of a Hsp40 from Saccharomyces cerevisiae, named Sis1.	Hydrogen	22-24	type II HSP40 co-chaperone SIS1	Saccharomyces cerevisiae S288C	124-128
31532899-4	2021	Surface and interface engineering have shown bright prospects to construct highly efficient Mox C-based electrocatalysts for energy conversion including the hydrogen evolution reaction, oxygen evolution reaction, nitrogen reduction reaction, and carbon dioxide reduction reaction.	Hydrogen	157-165	monooxygenase DBH like 1	Homo sapiens	92-95
8051099-0	1994	Subunit association and structural analysis of platelet basic protein and related proteins investigated by 1H NMR spectroscopy and circular dichroism.	Hydrogen	107-109	pro-platelet basic protein	Homo sapiens	47-69
33428957-6	2021	We also characterized the affinity of lentinan to dectin-1 by LSPR and binding free energy calculation, and we found out that hydrogen bonds and CH-pi interaction are the major contributors for lentinan"s binding to dectin-1.	Hydrogen	126-134	C-type lectin domain containing 7A	Homo sapiens	50-58
29933187-4	2018	In case of potatoes wastes, the hydrogen yield ranged between 126.4 and 252.7 mL-H2/g-TVS using pre-treated samples compared to 58.7 mL-H2/g-TVS observed in the reference test.	Hydrogen	32-40	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	78-83
29933187-5	2018	Pre-treated bean wastes showed hydrogen yield of 93.0-152.1 mL-H2/g-TVS higher than 53.3 mL-H2/g-TVS measured in the control test.	Hydrogen	31-39	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	60-65
33428957-6	2021	We also characterized the affinity of lentinan to dectin-1 by LSPR and binding free energy calculation, and we found out that hydrogen bonds and CH-pi interaction are the major contributors for lentinan"s binding to dectin-1.	Hydrogen	126-134	C-type lectin domain containing 7A	Homo sapiens	216-224
8062828-5	1994	To investigate the structural basis of receptor specificity, we have determined the solution structure of the EGF-like domain of HRG-alpha by two-dimensional 1H nuclear magnetic resonance spectroscopy and simulated annealing calculations.	Hydrogen	158-160	neuregulin 1	Homo sapiens	129-138
33444457-0	2021	Hydrogen-deuterium exchange reveals a dynamic DNA-binding map of replication protein A.	Hydrogen	0-8	replication protein A1	Homo sapiens	65-86
29800876-6	2018	The removal of dyes by Zr-MOFs-PUF membrane was mainly attributed to the electrostatic interactions, hydrogen bond interaction, and Lewis acid-base interactions between the membrane and dye molecules.	Hydrogen	101-109	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	31-34
8193120-8	1994	The structure is partially stabilized by a charged hydrogen bond between the side chains of Arg-1 and Asp-3.	Hydrogen	51-59	arginase 1	Homo sapiens	92-97
30156844-4	2018	Conjugation of PAMAM G3.0 with lactoferrin was confirmed by FT-IR, 1H NMR, and 2D-NMR spectroscopy as well as AFM techniques.	Hydrogen	67-69	lactotransferrin	Rattus norvegicus	31-42
33248847-7	2021	It also provided structural determinants affecting both the binding position and the matching affinities, identifying the attached NMe2 group as the most dominant in promoting the binding, which allows ligands to optimize favourable cation   pi and hydrogen bonding interactions with Lys352.	Hydrogen	249-257	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	131-135
33464267-4	2021	Specifically, the S site acts as the active site and sustains CO selectivity, while the Se site shows a higher tendency of hydrogen evolution.	Hydrogen	123-131	squalene epoxidase	Homo sapiens	88-90
8161501-7	1994	The NMR spectrum and resulting solution structure of PAPA suggest that a side-chain to side-chain hydrogen bond involving an arginine and an aspartic acid analogous to one observed in the Zif268 protein-DNA cocrystal structure exists in solution in the absence of DNA [Pavletich, N. P., &amp; Pabo, C. O.	Hydrogen	98-106	pappalysin 1	Homo sapiens	53-57
33557164-6	2021	This deviation was attributed to hydrogen bonds of CAR with TRP ether groups.	Hydrogen	33-41	CXADR pseudogene 1	Homo sapiens	51-54
33854899-3	2021	Due to the coordinate and hydrogen bonds in the water-soluble polyacrylamide hydrogel, MoP is uniformly confined in a 3D porous NC to form ultrafine nanoparticles which facilitate the extreme exposure of abundant three-phase boundaries (MoP, NC, and electrolyte) for ionic binding and storage.	Hydrogen	26-34	opioid receptor mu 1	Homo sapiens	87-90
30068652-7	2018	Using a molecular dynamic simulation, we observed that both gag-PTAP and ORF3-PSAP motifs bind to the same site in UEV-TSG101 by hydrogen bonding.	Hydrogen	129-137	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	73-77
30068652-7	2018	Using a molecular dynamic simulation, we observed that both gag-PTAP and ORF3-PSAP motifs bind to the same site in UEV-TSG101 by hydrogen bonding.	Hydrogen	129-137	tumor susceptibility 101	Homo sapiens	119-125
29745030-8	2018	Molecular docking study indicated that hydrogen bonds, van der Waals, charge interactions and Pi-cation interactions all contributed to affinity between 3l and alpha-glucosidase/PTP1B.	Hydrogen	39-47	sucrase-isomaltase	Homo sapiens	160-177
29921037-7	2018	Furthermore, H2 promoted the expression of pro-healing factors (IL-22, TGF-beta, VEGF and IGF1) and inhibited the production of MMP9 in wound tissue in parallel with acceleration of cutaneous collagen synthesis.	Hydrogen	13-15	interleukin 22	Mus musculus	64-69
29936999-4	2018	ALOX5 is the rate-limiting enzyme in leukotriene synthesis and, following T/HS, contributes to the development of lung dysfunction.	Hydrogen	76-78	arachidonate 5-lipoxygenase	Rattus norvegicus	0-5
32975902-0	2021	OCRE Domains of Splicing Factors RBM5 and RBM10: Tyrosine Ring Flip Frequencies by Integrated Use of 1H-NMR and Molecular Dynamics Simulations.	Hydrogen	101-103	RNA binding motif protein 10	Homo sapiens	42-47
29936999-6	2018	We hypothesized that T/HS results in the molecular association and nuclear colocalization of ALOX5 and ALOX5AP, which ultimately increases leukotriene production and potentiates lung injury.	Hydrogen	23-25	arachidonate 5-lipoxygenase	Rattus norvegicus	93-98
8294406-0	1994	Hydrogen bonding interaction of thyrotropin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor.	Hydrogen	0-8	thyrotropin releasing hormone	Homo sapiens	32-61
30027186-4	2018	Ir1 was found to be weakly emissive in CH3CN-H2O, which is probably due to the effect of hydrogen bonding between the orotate ligands and H2O molecules.	Hydrogen	89-97	nischarin	Homo sapiens	0-3
8294406-0	1994	Hydrogen bonding interaction of thyrotropin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor.	Hydrogen	0-8	thyrotropin releasing hormone	Homo sapiens	63-66
8288615-8	1994	These models suggest that both specific and nonspecific hydrogen bonding play a critical role in the ability of EKLF to prefer binding to its cognate site.	Hydrogen	56-64	Kruppel like factor 1	Homo sapiens	112-116
30043012-0	2018	A Mn13-cluster based coordination polymer as a co-catalyst of CdS for enhanced visible-light driven H2 evolution.	Hydrogen	100-102	CDP-diacylglycerol synthase 1	Homo sapiens	62-65
30043012-1	2018	A coordination cluster-based polymer was used for the first time as a noble-metal-free co-catalyst of CdS, giving rise to significantly enhanced photocatalytic H2 production.	Hydrogen	160-162	CDP-diacylglycerol synthase 1	Homo sapiens	102-105
33597886-10	2020	Molecular docking analysis showed that two hydrogen bonds between compound 3 and residues Asp209(TLR4) and Asp99(MD-2) mainly contribute to the TLR4 inhibition.	Hydrogen	43-51	toll like receptor 4	Homo sapiens	97-101
33597886-10	2020	Molecular docking analysis showed that two hydrogen bonds between compound 3 and residues Asp209(TLR4) and Asp99(MD-2) mainly contribute to the TLR4 inhibition.	Hydrogen	43-51	toll like receptor 4	Homo sapiens	144-148
33448281-4	2021	In the context of the caspase-3 conformational landscape, we show that changes in hydrogen bonding near the S3 subsite affect selection of the P4 amino acid.	Hydrogen	82-90	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	22-31
7925487-13	1993	The distribution demonstrated that glutaredoxin serves functions apart from the originally described role as hydrogen donor for ribonucleotide reductase which only occurs in replicating cells.	Hydrogen	109-117	glutaredoxin	Homo sapiens	35-47
33448281-6	2021	Within the context of the caspase-3 conformational landscape, substitutions near the active site result in nearly equal activity against DxxD and VxxD by disrupting a hydrogen bonding network in the substrate binding pocket.	Hydrogen	167-175	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	26-35
33405905-3	2021	The {V6}-MOF not only expands the structure of polyoxovanadates (POVs) but also catalyzes the rapid detoxification of mustard gas simulant (2-chloroethyl ethyl sulfide, CEES) at 25  C. The catalytic results were determined by means of GC, GC-MS, and 1H NMR.	Hydrogen	250-252	gastrin	Homo sapiens	126-129
8253841-5	1993	When coexpressed in Xenopus oocytes with a beta subunit isolated from the same cDNA library, the ATPase is able to transport rubidium (a potassium surrogate) inward, and hydrogen outward, leading to alkalization of the intracellular compartment and acidification of the external medium.	Hydrogen	170-178	dynein axonemal heavy chain 8	Homo sapiens	97-103
33183632-7	2021	Isothermal titration calorimetry (ITC) results illustrated that the binding of CSP80 to alpha-glucosidase complex was spontaneous driven by enthalpy and hydrogen bonds played a major role in the binding.	Hydrogen	153-161	sucrase-isomaltase	Homo sapiens	88-105
33295908-3	2021	The GM could enter into the active site of alpha-glucosidase and bind with the catalytic amino acid residues through hydrogen bonding and pi-conjugation, thus playing an important role in the competitive inhibition of catechins and theaflavins.	Hydrogen	117-125	sucrase-isomaltase	Homo sapiens	43-60
8254619-13	1993	The structure-activity correlates are suggestive of a hydrogen-bond interaction between a donor moiety on the PGI2 receptor and the methoxycarbonyl functionality of 12a that is sensitive to both the size of the substituent and its stereochemical presentation in this structural class of PGI2 mimetic.	Hydrogen	54-62	prostaglandin I2 receptor	Homo sapiens	110-123
33410376-7	2021	Our calculations showed that these compounds were able to, simultaneously, form hydrogen bonds with residues of the catalytic site and the secondary binding site of RTA, qualifying as potential antidotes against intoxication by ricin.	Hydrogen	80-88	MAS related GPR family member F	Homo sapiens	165-168
8245728-9	1993	Full 1H and 13C NMR assignments are presented for VIII, XXI, and intermediates involved in their synthesis.	Hydrogen	5-7	cytochrome c oxidase subunit 8A	Homo sapiens	50-54
33268465-5	2021	Hydrogen-deuterium exchange mass spectrometry (HDX-MS) analysis revealed that CUL5 neddylation allosterically exposes its ARIH2 binding site, promoting high affinity binding, and it also sequesters the NEDD8 E2 (UBE2F) binding site on RBX2.	Hydrogen	0-8	cullin 5	Homo sapiens	78-82
8374057-5	1993	We also report the solution-state 1H NMR assignment of the trans-syn-II photodimer of TpT and its (Rp)-methyl phosphate ester by way of 2D homonuclear Hartmann--Hahn experiment, rotating frame nuclear Overhauser effect spectroscopy, and proton-detected 1H-31P correlation spectroscopy.	Hydrogen	253-255	decaprenyl diphosphate synthase subunit 1	Homo sapiens	86-89
32902899-0	2021	Redox-Mediated Alcohol Oxidation Coupled to Hydrogen Gas Formation in a Dye-Sensitized Photosynthesis Cell.	Hydrogen	44-52	gastrin	Homo sapiens	53-56
8374057-6	1993	Conformational analysis of three-bond 1H-1H, 1H-31P, and 13C-31P coupling constant data established a close similarity between the solution-state structures of the trans-syn-II photodimer of TpT and its (Rp)-methyl phosphate ester, with the crystal structure of the methyl phosphate ester.	Hydrogen	38-40	decaprenyl diphosphate synthase subunit 1	Homo sapiens	191-194
8374057-6	1993	Conformational analysis of three-bond 1H-1H, 1H-31P, and 13C-31P coupling constant data established a close similarity between the solution-state structures of the trans-syn-II photodimer of TpT and its (Rp)-methyl phosphate ester, with the crystal structure of the methyl phosphate ester.	Hydrogen	41-43	decaprenyl diphosphate synthase subunit 1	Homo sapiens	191-194
32964599-4	2021	Here, as a proof-of-concept, we presented a combination of theoretical and experimental investigation to certify that nickel diphosphide phase-junction (c-NiP 2 /m-NiP2 ) is an effective electrocatalyst for hydrogen production in alkaline media.	Hydrogen	207-215	BCL2 interacting protein 2	Homo sapiens	164-168
8374057-6	1993	Conformational analysis of three-bond 1H-1H, 1H-31P, and 13C-31P coupling constant data established a close similarity between the solution-state structures of the trans-syn-II photodimer of TpT and its (Rp)-methyl phosphate ester, with the crystal structure of the methyl phosphate ester.	Hydrogen	41-43	decaprenyl diphosphate synthase subunit 1	Homo sapiens	191-194
8507640-2	1993	Arg(E10) was previously found to form a hydrogen bond with the ligand in fluoro-, azido- and cyanomet derivatives of Aplysia limacina myoglobin, which lacks the distal His(E7) [Qin, J., La Mar, G. N., Ascoli, F., Bolognesi, M., &amp; Brunori, M. (1992) J. Mol.	Hydrogen	40-48	myoglobin	Physeter catodon	134-143
8515458-9	1993	Groups that can form hydrogen bonds in a similar way to amide groups occur in several nucleotide bases; we find one example of a 9-membered ring involving adenine and main-chain atoms in the FAD-protein complex of glutathione reductase.	Hydrogen	21-29	glutathione-disulfide reductase	Homo sapiens	214-235
33397920-4	2021	Here we show that TERT and ALT are associated with unique 1H-magnetic resonance spectroscopy (MRS)-detectable metabolic signatures in genetically-engineered and patient-derived glioma models and patient biopsies.	Hydrogen	58-60	telomerase reverse transcriptase	Homo sapiens	18-22
8357536-7	1993	The histidines beta 2 and beta 143 of the two beta-chains form hydrogen bonds with the phosphates.	Hydrogen	63-71	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	15-21
33246255-7	2021	Further molecular docking study revealed that 6c fitted ideally into DDR1 binding pocket and maintained the crucial hydrogen bonds with DDR1 kinase domain.	Hydrogen	116-124	discoidin domain receptor tyrosine kinase 1	Homo sapiens	69-73
33246255-7	2021	Further molecular docking study revealed that 6c fitted ideally into DDR1 binding pocket and maintained the crucial hydrogen bonds with DDR1 kinase domain.	Hydrogen	116-124	discoidin domain receptor tyrosine kinase 1	Homo sapiens	136-140
33284596-6	2020	The hydrogen evolution reaction on MOx/Ag(111) can be suppressed due to the significantly higher Gibbs free energy for hydrogen adsorption (DeltaGH*), thereby enhancing the selectivity toward CO2RR.	Hydrogen	4-12	monooxygenase DBH like 1	Homo sapiens	35-38
33284596-6	2020	The hydrogen evolution reaction on MOx/Ag(111) can be suppressed due to the significantly higher Gibbs free energy for hydrogen adsorption (DeltaGH*), thereby enhancing the selectivity toward CO2RR.	Hydrogen	119-127	monooxygenase DBH like 1	Homo sapiens	35-38
33252213-6	2020	Herein, we report a highly biocompatible nanoconjugate composed of pH-responsive 19F nucleus-bearing Gd3+ chelates, which enables significant contrast enhancement for T1-weighted 1H MRI and permits pH-responsive activation of 19F signals for 19F MRI, providing both clear anatomical details of living bodies and the biorelevant molecular information with low background interference.	Hydrogen	179-181	GRDX	Homo sapiens	101-104
33256396-0	2020	Gas-Phase Peptide Fragmentation Induced by Hydrogen Attachment, from Principle to Sequencing of Amide Nitrogen-Methylated Peptides.	Hydrogen	43-51	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	0-3
33185633-2	2020	Structural characterization confirmed the formation of a strong hydrogen-bond network, responsible for enhanced cooperativity in the materials and thus largely complete spin-state transitions for the ligands with chain lenghts of C2 and C4.	Hydrogen	64-72	complement C2	Homo sapiens	230-239
33137558-5	2020	Metal chelating, hydrogen bonding or Van Der Waals force may drive the interaction between the polyphenolic compounds and Abeta.	Hydrogen	17-25	amyloid beta (A4) precursor protein	Mus musculus	122-127
32814064-10	2020	Multiplex cytokine assay demonstrated the most profound regulatory effects induced by HI on the levels of IL-12, IFN-gamma, and GM-CSF at 24 h post-TBI, which confirmed the inhibitory effect of hydrogen on microglia activation.	Hydrogen	194-202	interleukin 12B	Rattus norvegicus	106-111
32814064-10	2020	Multiplex cytokine assay demonstrated the most profound regulatory effects induced by HI on the levels of IL-12, IFN-gamma, and GM-CSF at 24 h post-TBI, which confirmed the inhibitory effect of hydrogen on microglia activation.	Hydrogen	194-202	interferon gamma	Rattus norvegicus	113-122
32906104-0	2020	O-GlcNAcylation inhibits the oligomerization of alpha-synuclein by declining intermolecular hydrogen bonds through a steric effect.	Hydrogen	92-100	synuclein alpha	Homo sapiens	48-63
32906104-4	2020	Based on the all-atom molecular dynamics (MD) simulations, we found that O-GlcNAc modifications can suppress the process of oligomerization of alpha-Syn aggregates via a steric effect - the additional O-linked glycosyl group disrupts the formation of hydrogen bonds (H-bonds) between alpha-Syn monomers.	Hydrogen	251-259	synuclein alpha	Homo sapiens	143-152
33170611-7	2020	More importantly, it is found that GCN containing abundant hydrogen bonds can be irreversibly anchored by carbonaceous gas fragments (CxHy+) released from various organic substances via thermogravimetry-differential thermal analysis coupled with mass spectrometry and X-ray photoelectron spectroscopy analysis, and the CxHy+ fragments exhibit a non-negligible role during the transformation.	Hydrogen	59-67	gastrin	Homo sapiens	119-122
33230173-7	2020	MD calculations show that there are five hydrogen bonds formed between CC-6 and the surrounding amino acid residues.	Hydrogen	41-49	NADH:ubiquinone oxidoreductase subunit A9	Homo sapiens	71-75
33169998-0	2020	Intramolecular Hydrogen Bonds in Tip-Functionalized Single-Walled Carbon Nanotubes as pH-Sensitive Gates.	Hydrogen	15-23	TOR signaling pathway regulator	Homo sapiens	33-36
32893396-1	2020	A theoretical study of the complexes formed by Ag 2 and Cu 2 with different molecules, XH (FH, ClH, OH 2 , SH 2 , HCN, HNC, HCCH, NH 3 and PH 3 ) that can act as hydrogen bond donors (Lewis acids) or regium bond acceptors (Lewis bases) were carried out at the CCSD(T)/CBS computational level.	Hydrogen	162-170	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	114-117
33089564-4	2020	p-RTP is associated with the unique semi-rigidified SA chains, effective hydrogen bonding network, and oxygen barrier properties of SA, whereas excitation-dependent and time-dependent afterglows should stem from the formation of diversified p-RTP emissive species with comparable but different lifetimes.	Hydrogen	73-81	MORN repeat containing 4	Homo sapiens	2-5
32886808-0	2020	Studies of hydrogen isotope scrambling during the dehalogenation of aromatic chloro-compounds with deuterium gas over palladium catalysts.	Hydrogen	11-19	gastrin	Homo sapiens	109-112
32048433-10	2020	These studies reveal that the benzodioxole moiety exhibits strong interactions due to hydrogen bonds that form with the Glu201 (AChE) and Tyr440 (BChE) residues, which is reflected in the IC 50 values.	Hydrogen	86-94	butyrylcholinesterase	Homo sapiens	146-150
33138036-9	2020	RESULTS: Evaluation of 1H-MRS data showed a decrease in 2-HG/total creatinine (tCr) ratios from the baseline to post-treatment scans in the mIDH1 murine model.	Hydrogen	23-25	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	140-145
32817167-9	2020	Finally, we used FRET to demonstrate that CV-3 inhibited the interaction between Vif and CBFbeta by simultaneously forming hydrogen bonds with residues Q67, I102 and R131 of CBFbeta.	Hydrogen	123-131	nuclear transcription factor Y subunit beta	Homo sapiens	89-96
32817167-9	2020	Finally, we used FRET to demonstrate that CV-3 inhibited the interaction between Vif and CBFbeta by simultaneously forming hydrogen bonds with residues Q67, I102 and R131 of CBFbeta.	Hydrogen	123-131	nuclear transcription factor Y subunit beta	Homo sapiens	174-181
32504902-6	2020	It gave a high current density of 92.8 mA cm-2 at 1.6 V vs. reversible hydrogen electrode (RHE) for MOR, along with the low overpotentials at the current density of 10 mV cm-2 (eta10) and Tafel slopes toward hydrogen evolution reaction (eta10 = 119 mV, Tafel slope = 46 mV dec-1) and oxygen evolution reaction (eta10 = 1.35 V, Tafel slope = 26 mV dec-1).	Hydrogen	71-79	opioid receptor mu 1	Homo sapiens	100-103
32996938-0	2020	Competition between the hydrogen bond and the halogen bond in a [CH3OH-CCl4] complex: a matrix isolation IR spectroscopy and computational study.	Hydrogen	24-32	C-C motif chemokine ligand 4	Homo sapiens	71-75
32996938-5	2020	The interaction between CH3OH and CCl4 at the molecular level can be twofold: hydrogen bond (O-HCl) and halogen bond (C-ClO) interaction.	Hydrogen	78-86	C-C motif chemokine ligand 4	Homo sapiens	34-38
32996938-7	2020	Herein, the 1 : 1 complex of [CH3OH-CCl4] has been characterised using matrix-isolation infrared spectroscopy and electronic structure calculations to investigate the competition between hydrogen bonded and halogen bonded complexes.	Hydrogen	187-195	C-C motif chemokine ligand 4	Homo sapiens	36-40
32526401-5	2020	In the SP5, the pillar[5]arene group act as C-H   pi interactions site, and ester group serve as multi hydrogen bonding acceptor.	Hydrogen	103-111	Sp5 transcription factor	Homo sapiens	7-10
29847705-2	2018	Here, we present a new efficient photocatalytic system consisting of CdS nanorods (NRs), Ni, and Co to liberate hydrogen from FA.	Hydrogen	112-120	CDP-diacylglycerol synthase 1	Homo sapiens	69-72
29925480-6	2018	Docking simulation implied that Cys323 and Tyr444 of MAO-A are key residues for hydrogen-bond interaction with chelerythrine.	Hydrogen	80-88	monoamine oxidase A	Homo sapiens	53-58
29863807-5	2018	Importantly, the truncated acyl chain containing variants still retain their binding affinities and agonistic activities, which can be associated with an "anchoring effect," that is, formation of a buried hydrogen bond between a polar group on the acyl chain and the CD1d lipid-binding pocket.	Hydrogen	205-213	CD1d molecule	Homo sapiens	267-271
29878882-5	2018	Isothermal titration calorimetry and hydrogen exchange mass spectroscopy were used to study the thermodynamic binding signature and changes in backbone dynamics of FOXP2 FHD DNA binding.	Hydrogen	37-45	forkhead box P2	Homo sapiens	164-169
29797369-1	2018	A series of intramolecularly hydrogen-bonded zwitterionic compartmental ligands HL1-HL4, containing a pendent diamine arm that is monoprotonated and an aldehyde functionality at two different ortho-positions of a 4-halophenoxide, is reported herein.	Hydrogen	29-37	intelectin 1	Homo sapiens	80-83
29993059-2	2018	Many complexes of the type BMX, (where B is a Lewis base such as H2, N2, ethyne, ethene, cyclopropane, H2O, H2S, PH3, or NH3, M is a coinage-metal atom Cu, Ag or Au, and X is a halogen atom) have now been characterised in the gas phase through their rotational spectra.	Hydrogen	65-67	BMX non-receptor tyrosine kinase	Homo sapiens	27-30
29872787-5	2018	The H2 desorption and MO reduction peaks demonstrated pH dependent, linear responses (49 +- 11 mV pH-1 and 76 +- 4 mV pH-1 respectively), following pre-activation of the electrode surface in HCl.	Hydrogen	4-6	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	98-122
29601177-0	2018	Pulsed Hydrogen-Deuterium Exchange Illuminates the Aggregation Kinetics of alpha-Synuclein, the Causative Agent for Parkinson"s Disease.	Hydrogen	7-15	synuclein alpha	Homo sapiens	75-90
29806457-0	2018	2D/2D Heterostructured CdS/WS2 with Efficient Charge Separation Improving H2 Evolution under Visible Light Irradiation.	Hydrogen	74-76	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
29806457-2	2018	Herein, we report two-dimensional (2D)/2D heterostructured CdS/WS2 (CdS/WS2), composed of nanosheet CdS (CdS) and nanosheet WS2 (WS2), as an efficient photocatalyst for H2 evolution.	Hydrogen	169-171	CDP-diacylglycerol synthase 1	Homo sapiens	59-62
29806457-2	2018	Herein, we report two-dimensional (2D)/2D heterostructured CdS/WS2 (CdS/WS2), composed of nanosheet CdS (CdS) and nanosheet WS2 (WS2), as an efficient photocatalyst for H2 evolution.	Hydrogen	169-171	CDP-diacylglycerol synthase 1	Homo sapiens	68-71
29806457-2	2018	Herein, we report two-dimensional (2D)/2D heterostructured CdS/WS2 (CdS/WS2), composed of nanosheet CdS (CdS) and nanosheet WS2 (WS2), as an efficient photocatalyst for H2 evolution.	Hydrogen	169-171	CDP-diacylglycerol synthase 1	Homo sapiens	68-71
29806457-2	2018	Herein, we report two-dimensional (2D)/2D heterostructured CdS/WS2 (CdS/WS2), composed of nanosheet CdS (CdS) and nanosheet WS2 (WS2), as an efficient photocatalyst for H2 evolution.	Hydrogen	169-171	CDP-diacylglycerol synthase 1	Homo sapiens	68-71
29806457-3	2018	As a noble metal-free visible light-driven catalyst for H2 evolution, CdS/WS2 with 10 wt % WS2 exhibited the largest H2 evolution rate of 14.1 mmol g-1 h-1 under visible light irradiation to be 8 times larger than that of pure CdS.	Hydrogen	56-58	CDP-diacylglycerol synthase 1	Homo sapiens	70-73
29806457-3	2018	As a noble metal-free visible light-driven catalyst for H2 evolution, CdS/WS2 with 10 wt % WS2 exhibited the largest H2 evolution rate of 14.1 mmol g-1 h-1 under visible light irradiation to be 8 times larger than that of pure CdS.	Hydrogen	117-119	CDP-diacylglycerol synthase 1	Homo sapiens	70-73
30310673-9	2018	Computational and experimental analysis elucidated the mechanism of toxicity as a consequence of influential functionality of Sod1 and p53 proteins due to interaction and internalization of the nanohybrids with amino acid residues via hydrogen bonds and hydrophobic interactions.	Hydrogen	235-243	transformation related protein 53, pseudogene	Mus musculus	135-138
28632421-5	2018	Molecular docking studies revealed that zinc ion coordination, hydrogen bonding, and hydrophobic interactions contributed to the high calculated binding affinities of these compounds toward HDAC8.	Hydrogen	63-71	histone deacetylase 8	Homo sapiens	190-195
29741363-4	2018	In this new catalytic system, oxygen-vacancy-rich NiO provides abundant active sites for dissociation of water, and the negatively charged P species in NiP2 facilitate adsorption of hydrogen intermediates.	Hydrogen	182-190	BCL2 interacting protein 2	Homo sapiens	152-156
29528228-4	2018	These protocols are employed to collect 2D 15N-1H HMQC NMR spectra of alpha-synuclein, showing residue-specific enhancements &gt;=100x over their thermal counterparts.	Hydrogen	47-49	synuclein alpha	Homo sapiens	70-85
8504086-0	1993	Solution structure determination of the heme cavity in the E7 His--&gt;Val cyano-met myoglobin point mutant based on the 1H NMR detected dipolar field of the iron: evidence for contraction of the heme pocket.	Hydrogen	121-123	myoglobin	Physeter catodon	85-94
32450537-1	2020	A naturally fluorescent cyanobacterial protein C-phycoerythrin (CPE) was investigated as a fluorescent probe for biologically and environmentally important hydrosulphide (HS-) ion.	Hydrogen	171-173	carboxypeptidase E	Homo sapiens	24-62
32450537-1	2020	A naturally fluorescent cyanobacterial protein C-phycoerythrin (CPE) was investigated as a fluorescent probe for biologically and environmentally important hydrosulphide (HS-) ion.	Hydrogen	171-173	carboxypeptidase E	Homo sapiens	64-67
7763526-3	1993	Structural analysis of the hydrogen bonding network around the two active site aspartates 32 and 215 in chymosin have suggested that residues Thr 218 and Asp 303 may influence the rate and pH optima for catalysis.	Hydrogen	27-35	chymosin	Bos taurus	104-112
32480277-3	2020	The hydroxylation at the positions C3, C6, C4", C5" (for type I) and C5, C3" (for type II) were in favor of forming hydrogen bonds with the amino acids of BSA, which was of great importance in the binding and interaction between flavonoids and the protein.	Hydrogen	116-124	complement C5	Homo sapiens	48-75
32747444-6	2020	Peptide binding is mediated by an extended hydrogen-bond network in NS3-4A that was effectively optimized for protease-MAVS binding in Asp168 variants with rescued replicative fitness from NS3-Q41R.	Hydrogen	43-51	mitochondrial antiviral signaling protein	Homo sapiens	119-123
29700523-0	2018	Hydrogen bonds of the imidazolium rings of ionic liquids with DMSO studied by NMR, soft X-ray spectroscopy, and SANS.	Hydrogen	0-8	USH1 protein network component sans	Homo sapiens	112-116
29439915-5	2018	The docking analysis showed that these thiazole-containing retinoids were well suited to the binding pocket of RARalpha, particularly via a favorable hydrogen bonding interaction between the thiazole and Ser232 of RARalpha.	Hydrogen	150-158	retinoic acid receptor alpha	Homo sapiens	111-119
29439915-5	2018	The docking analysis showed that these thiazole-containing retinoids were well suited to the binding pocket of RARalpha, particularly via a favorable hydrogen bonding interaction between the thiazole and Ser232 of RARalpha.	Hydrogen	150-158	retinoic acid receptor alpha	Homo sapiens	214-222
1281679-1	1992	The interactions of myelin basic protein with micelles of lysophosphatidylcholine detergents of different acyl chain lengths were investigated by circular dichroism (CD), small-angle X-ray scattering, Fourier transform infrared spectroscopy (FT-IR), and 1H, 13C and 31P nuclear magnetic resonance spectroscopy (NMR).	Hydrogen	254-256	myelin basic protein	Homo sapiens	20-40
29580500-4	2018	Hydrogen bonding and van der Waals forces played the major roles in the interaction of beta-CN with C3G, their affinity decreasing with increasing preheating temperature at both pH values.	Hydrogen	0-8	casein beta	Homo sapiens	87-94
1629626-5	1992	Four amino acid replacements, resulting in a net positive change in non-hydrogen atoms in the S1" subsite of MC-CPA, were associated with less alteration in substrate specificity, relative to bovine CPA, than might be expected from studies using rat CPA1 and CPA2.	Hydrogen	72-80	carboxypeptidase A2	Rattus norvegicus	259-263
32554895-5	2020	After being uniformly loaded with 4 wt.% of the Pt nanoparticles, the TiO2 nanosheets displayed a photocatalytic hydrogen production rate of 2.239 mmol g-1 h-1 under simulated solar light, which was much higher than the pristine TiO2 nanosheets (0.045 mmol g-1 h-1) as well as most of the reported TiO2-based photocatalysts.	Hydrogen	113-121	H1.5 linker histone, cluster member	Homo sapiens	156-159
29498161-0	2018	Tailoring the d-Band Centers Enables Co4 N Nanosheets To Be Highly Active for Hydrogen Evolution Catalysis.	Hydrogen	78-86	complement C4A (Rodgers blood group)	Homo sapiens	37-40
1391626-2	1992	In the crystalline state, the peptide chain assumes a right-handed 3(10)-helical conformation stabilized by two intramolecular hydrogen bonds, between the N-terminal acetyl group and the NH of delta Phe3, and between the CO of delta Phe1 and the NH of the C-terminal methylamide group, respectively.	Hydrogen	127-135	dihydrolipoamide dehydrogenase	Homo sapiens	199-203
29498161-2	2018	Co4 N, with its beneficial metallic characteristics, has been proved to be highly active for the oxidation of water, while it is notoriously poor for catalyzing the hydrogen evolution reaction (HER), because of its unfavorable d-band energy level.	Hydrogen	165-173	complement C4A (Rodgers blood group)	Homo sapiens	0-3
29578709-1	2018	Conformational preferences of a binary hydrogen-bonded complex between p-fluorophenol (pFP) and 2,5-dihydrofuran (DHF) have been studied by means of laser induced fluorescence (LIF) spectroscopy in a supersonic jet expansion.	Hydrogen	39-47	perforin 1	Homo sapiens	87-90
32554895-5	2020	After being uniformly loaded with 4 wt.% of the Pt nanoparticles, the TiO2 nanosheets displayed a photocatalytic hydrogen production rate of 2.239 mmol g-1 h-1 under simulated solar light, which was much higher than the pristine TiO2 nanosheets (0.045 mmol g-1 h-1) as well as most of the reported TiO2-based photocatalysts.	Hydrogen	113-121	H1.5 linker histone, cluster member	Homo sapiens	261-264
1534729-0	1992	Effect of a single dose of lactase on symptoms and expired hydrogen after lactose challenge in lactose-intolerant subjects.	Hydrogen	59-67	lactase	Homo sapiens	27-34
29609454-0	2018	Pt-like Hydrogen Evolution Electrocatalysis on PANI/CoP Hybrid Nanowires by Weakening the Shackles of Hydrogen Ions on the Surfaces of Catalysts.	Hydrogen	8-16	caspase recruitment domain family member 16	Homo sapiens	52-55
29609454-0	2018	Pt-like Hydrogen Evolution Electrocatalysis on PANI/CoP Hybrid Nanowires by Weakening the Shackles of Hydrogen Ions on the Surfaces of Catalysts.	Hydrogen	102-110	caspase recruitment domain family member 16	Homo sapiens	52-55
29609454-3	2018	Here we realize Pt-like hydrogen evolution electrocatalysis on polyaniline (PANI) nanodots (NDs)-decorated CoP hybrid nanowires (HNWs) supported on carbon fibers (CFs) (PANI/CoP HNWs-CFs) as PANI can effectively capture H+ from hydronium ions to form protonated amine groups that have higher positive charge density than those of hydronium ions and can be electro-reduced easily.	Hydrogen	24-32	caspase recruitment domain family member 16	Homo sapiens	107-110
29609454-3	2018	Here we realize Pt-like hydrogen evolution electrocatalysis on polyaniline (PANI) nanodots (NDs)-decorated CoP hybrid nanowires (HNWs) supported on carbon fibers (CFs) (PANI/CoP HNWs-CFs) as PANI can effectively capture H+ from hydronium ions to form protonated amine groups that have higher positive charge density than those of hydronium ions and can be electro-reduced easily.	Hydrogen	24-32	caspase recruitment domain family member 16	Homo sapiens	174-177
1534729-8	1992	The maximum mean breath hydrogen concentration was significantly lower after lactase treatment than after placebo treatment.	Hydrogen	24-32	lactase	Homo sapiens	77-84
1534729-9	1992	In 21 subjects, the area under the hydrogen concentration-time curve (AUC) was lower after lactase than after placebo; three subjects had hydrogen AUCs more than 300 ppm.hr lower.	Hydrogen	35-43	lactase	Homo sapiens	91-98
29400001-0	2018	WS2 /Graphitic Carbon Nitride Heterojunction Nanosheets Decorated with CdS Quantum Dots for Photocatalytic Hydrogen Production.	Hydrogen	107-115	CDP-diacylglycerol synthase 1	Homo sapiens	71-74
1534729-12	1992	Single doses of a chewable lactase tablet reduced the concentration of expired hydrogen and symptoms of lactose intolerance after a lactose challenge.	Hydrogen	79-87	lactase	Homo sapiens	27-34
29400001-3	2018	Optimized CdS/WS2 /CN without another cocatalyst exhibits a significantly enhanced photocatalytic H2 evolution rate of 1174.5 mumol h-1  g-1 under visible-light irradiation (lambda&gt;420 nm), which is nearly 67 times higher than that of the pure CN nanosheets.	Hydrogen	98-100	CDP-diacylglycerol synthase 1	Homo sapiens	10-13
29400001-6	2018	In addition, the CdS/WS2 /CN photocatalyst shows excellent stability and reusability without apparent decay in the photocatalytic H2 evolution within 4 cycles in 20 h. It is believed that this work may shed light on specifically designed 2D/2D nanosheet heterostructures for more efficient visible-light-driven photocatalysts.	Hydrogen	130-132	CDP-diacylglycerol synthase 1	Homo sapiens	17-20
1637752-1	1992	To obtain better insights into the dynamic nature of hydrogen bonding, computer graphics representations were introduced as an aid for the analysis of molecular dynamics trajectories.	Hydrogen	53-61	activation induced cytidine deaminase	Homo sapiens	127-130
29632890-3	2018	We show that, simulating a geoelectrochemical environment in deep-sea hydrothermal fields, CO production with up to ~40% Faraday efficiency was attainable on CdS in CO2-saturated NaCl solution at &lt;=-1 V (versus the standard hydrogen electrode).	Hydrogen	227-235	CDP-diacylglycerol synthase 1	Homo sapiens	158-161
29339412-4	2018	Hydrogen-deuterium exchange mass spectrometry localized the dominant region in AGR2 that interacts with the TTIYY peptide to within a structural loop from amino acids 131-135 (VDPSL).	Hydrogen	0-8	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	79-83
29339412-9	2018	Hydrogen-deuterium exchange mass spectrometry was used to identify a stable binding site for AGR2 on EpCAM, adjacent to the TLIYY motif and surrounding EpCAM"s detergent binding site.	Hydrogen	0-8	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	93-97
1555583-0	1992	Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII.	Hydrogen	18-20	apolipoprotein C2	Homo sapiens	106-124
29511885-7	2018	With regards to binding affinity, we found that hydrogen-bond interactions of Asn51 and Glu75, located in the active site of hSGLT2, with compound 40 were critical.	Hydrogen	48-56	solute carrier family 5 member 2	Homo sapiens	125-131
1734969-0	1992	Sequence-specific 1H NMR assignments and solution structure of bovine pancreatic polypeptide.	Hydrogen	18-20	pancreatic polypeptide	Bos taurus	70-92
1734969-1	1992	Sequence-specific 1H NMR assignments for the 36 residue bovine pancreatic polypeptide (bPP) have been completed.	Hydrogen	18-20	pancreatic polypeptide	Bos taurus	63-85
1605801-1	1992	Preferable conformations of thyrotropin-releasing hormone (TRH, Glp-His-Pro-NH2) and its analogues Glp-Glu(R)-Pro-NH2 (R = NHCH(CH3)CH2Ar), Glp-Gln-Abu-NH2, Dho-Gln-Abu-NH2 in DMSO solution are determined using two-dimensional 1H NMR spectroscopy (delta-J-correlated, COSY and NOESY).	Hydrogen	227-229	thyrotropin releasing hormone	Homo sapiens	28-57
29604765-2	2018	Measurements of the UCN transmission through cryogenic liquids and solids of interest, such as hydrogen (H2) and deuterium (D2), require sample containers with thin, highly polished and optically transparent windows and a well defined sample thickness.	Hydrogen	95-103	urocortin	Homo sapiens	20-23
29604765-2	2018	Measurements of the UCN transmission through cryogenic liquids and solids of interest, such as hydrogen (H2) and deuterium (D2), require sample containers with thin, highly polished and optically transparent windows and a well defined sample thickness.	Hydrogen	105-107	urocortin	Homo sapiens	20-23
29137744-2	2018	Structural analysis show that two CPs feature uninodal 3-connected 2D hcb layer, whilst CP 2 is further extended into a 3D complicated supramolecular network by C14-H14 O2 hydrogen bonds.	Hydrogen	172-180	ceruloplasmin	Homo sapiens	88-92
1605801-1	1992	Preferable conformations of thyrotropin-releasing hormone (TRH, Glp-His-Pro-NH2) and its analogues Glp-Glu(R)-Pro-NH2 (R = NHCH(CH3)CH2Ar), Glp-Gln-Abu-NH2, Dho-Gln-Abu-NH2 in DMSO solution are determined using two-dimensional 1H NMR spectroscopy (delta-J-correlated, COSY and NOESY).	Hydrogen	227-229	thyrotropin releasing hormone	Homo sapiens	59-62
1730598-8	1992	Infrared experiments showed that the hydrogen-deuterium exchange rate is much higher for TGF-alpha than for EGF, indicating that TGF-alpha is a more flexible molecule.	Hydrogen	37-45	transforming growth factor alpha	Homo sapiens	89-98
29441376-6	2018	The results reveal that the alkyl chains and functional groups on the TTF skeleton synergistically affect the molecular self-assembly process, which results from the synergism of van der Waals, hydrogen bonding, and SS interactions.	Hydrogen	194-202	ras homolog family member H	Homo sapiens	70-73
1730598-8	1992	Infrared experiments showed that the hydrogen-deuterium exchange rate is much higher for TGF-alpha than for EGF, indicating that TGF-alpha is a more flexible molecule.	Hydrogen	37-45	transforming growth factor alpha	Homo sapiens	129-138
1765591-6	1991	Deimination of alpha s1-casein resulted in altering its characteristics, possibly by interfering with interactions through hydrophobicity and/or hydrogen bonding.	Hydrogen	145-153	casein alpha s1	Homo sapiens	15-30
30108955-8	2018	Compound 9d interacts with rVEGF through hydrogen bonds in silico, thereby down-regulating the expression of VEGF in angiogenesis.	Hydrogen	41-49	vascular endothelial growth factor A	Rattus norvegicus	27-32
1931970-7	1991	All of the crucial amino acid residues are conserved in human GPT, which seem to be hydrogen bonding to pyridoxal 5"-phosphate in rat GPT by the sequence homology to other alpha-aminotransferases with known tertiary structures.	Hydrogen	84-92	glutamic--pyruvic transaminase	Homo sapiens	62-65
29420634-3	2018	Herein, we used hydrogen/deuterium exchange mass spectrometry (HDXMS) to study regulation of activity in the catalytic domain of the murine version of uPA (muPA) by two muPA specific monoclonal antibodies.	Hydrogen	16-24	plasminogen activator, urokinase	Mus musculus	151-154
29355259-0	2018	Porous CoP nanosheets converted from layered double hydroxides with superior electrochemical activity for hydrogen evolution reactions at wide pH ranges.	Hydrogen	106-114	caspase recruitment domain family member 16	Homo sapiens	7-10
2069576-1	1991	We have recorded 1H NMR spectra in H2O for exchangeable protons of four pyridoxal phosphate-dependent enzymes: D-serine dehydratase, aspartate aminotransferase, tryptophan: indole-lyase and glutamate decarboxylase.	Hydrogen	17-19	serine racemase	Homo sapiens	111-131
2067016-1	1991	1H nuclear magnetic resonance studies of (Cd2+)1-bovine calbindin D9k.	Hydrogen	0-2	S100 calcium binding protein G	Bos taurus	56-69
2067016-2	1991	The molecular basis for the co-operativity in binding of calcium ions by bovine calbindin D9k has been addressed by carrying out a comparative analysis of the solution conformation and dynamics of the apo, half saturated and fully saturated species using two-dimensional 1H nuclear magnetic resonance spectroscopy.	Hydrogen	271-273	S100 calcium binding protein G	Bos taurus	80-93
2060630-2	1991	The PPIase catalysis toward the substrate Suc-Ala-Phe-Pro-Phe-pNA has been studied by 1H NMR spectroscopy.	Hydrogen	86-88	peptidylprolyl isomerase like 3	Homo sapiens	4-10
1826561-5	1991	1H NMR spectroscopic examination of the reacted chromophore, isolated by HPLC, indicated that 2H was selectively abstracted by C-6, providing experimental corroboration of the model and further elucidating the chemical mechanism.	Hydrogen	0-2	complement C6	Homo sapiens	127-130
2015277-4	1991	Using modified MBS (metamaleimidobenzoyl-N-hydroxysuccinimide ester) method, bilirubin-IX alpha was covalently coupled to bovine serum albumin (BSA) retaining its intramolecular hydrogen bonds as well as three-dimensional structure.	Hydrogen	178-186	albumin	Mus musculus	129-142
2015827-1	1991	1H-NMR measurements were made of solutions of yeast phosphoglycerate kinase containing the nucleotide, ADP, and Mg2+ in varying concentrations in order to investigate the affect that the metal ion has on the mode of ADP binding to the enzyme.	Hydrogen	0-2	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	52-75
32468417-0	2020	1H, 13C and 15N NMR chemical shift assignments of cAMP-regulated phosphoprotein-19 and -16 (ARPP-19 and ARPP-16).	Hydrogen	0-2	cAMP regulated phosphoprotein 19	Homo sapiens	50-90
32468417-0	2020	1H, 13C and 15N NMR chemical shift assignments of cAMP-regulated phosphoprotein-19 and -16 (ARPP-19 and ARPP-16).	Hydrogen	0-2	cAMP regulated phosphoprotein 19	Homo sapiens	92-99
32468417-0	2020	1H, 13C and 15N NMR chemical shift assignments of cAMP-regulated phosphoprotein-19 and -16 (ARPP-19 and ARPP-16).	Hydrogen	0-2	cAMP regulated phosphoprotein 19	Homo sapiens	104-111
1900511-2	1991	One water is tightly bound to Asp76(O delta), Thr93(O gamma), Cys6(O), and Asn9(N); another bridges two loops by hydrogen-bonding to Tyr68(O eta) and to Ser35(N), Asn36(N); a loop structure is stabilized by two waters coordinated to Gly31(O) and His27(N delta), and by water bound to cis-Pro39(O).	Hydrogen	113-121	endothelin receptor type A	Homo sapiens	141-144
32468417-5	2020	Here, we report the resonance assignment of backbone 1H, 13C and 15N atoms of human ARPP-19 and ARPP-16 proteins.	Hydrogen	53-55	cAMP regulated phosphoprotein 19	Homo sapiens	84-91
32468417-5	2020	Here, we report the resonance assignment of backbone 1H, 13C and 15N atoms of human ARPP-19 and ARPP-16 proteins.	Hydrogen	53-55	cAMP regulated phosphoprotein 19	Homo sapiens	96-103
1993183-0	1991	Sequence-specific 1H NMR assignments and structural characterization of bovine seminal fluid protein PDC-109 domain b. Sequence-specific resonance assignments for the isolated second or b domain of the bovine seminal fluid protein PDC-109 have been obtained from analysis of two-dimensional 1H NMR experiments recorded at 500 MHz.	Hydrogen	18-20	seminal plasma protein PDC-109	Bos taurus	231-238
1993183-0	1991	Sequence-specific 1H NMR assignments and structural characterization of bovine seminal fluid protein PDC-109 domain b. Sequence-specific resonance assignments for the isolated second or b domain of the bovine seminal fluid protein PDC-109 have been obtained from analysis of two-dimensional 1H NMR experiments recorded at 500 MHz.	Hydrogen	291-293	seminal plasma protein PDC-109	Bos taurus	101-108
1997319-8	1991	The 1H-NMR spectra of the native and modified caldesmon showed that the covalent cross-linking affected mainly the central and N-terminal parts of the molecule.	Hydrogen	4-6	caldesmon 1	Gallus gallus	46-55
33039052-3	2020	The molecular docking revealed that compound 10f could bind to alpha-glucosidase via the hydrophobic, pi-pi stacking, and hydrogen bonding interactions.	Hydrogen	122-130	sucrase-isomaltase	Homo sapiens	63-80
1667635-2	1991	While the electron transfer in glutathione reductase requires only small movements of a couple of non-hydrogen atoms, the transfer of a phosphoryl group in the nucleotide kinases involves major rearrangements with main chain displacements of up to 32 A.	Hydrogen	102-110	glutathione-disulfide reductase	Homo sapiens	31-52
32998374-7	2020	hydrogen and ionic interactions, with essential residues, i.e., His218, Glu219, His222, and His228, in the active pocket of MMP-1.	Hydrogen	0-8	matrix metallopeptidase 1	Homo sapiens	124-129
32735805-4	2020	Here, we have characterized the DNA-binding domain of human FoxP1 by integrating single-molecule Forster Resonance Energy Transfer (FRET) and Hydrogen-Deuterium Exchange coupled with Mass Spectrometry (HDXMS) data with Molecular Dynamics (MD) simulations.	Hydrogen	142-150	forkhead box P1	Homo sapiens	60-65
2145515-4	1990	Here we describe circular dichroism and 1H-NMR spectroscopic studies of another family member, the yeast transcriptional activator GCN4.	Hydrogen	40-42	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	131-135
32887859-2	2020	(E)-3-Acetyl-4-[2-(4-methoxyphenyl)ethenyl]-2-methylquinoline, C21H19NO2, (I), (E)-3-acetyl-4-[2-(4-bromophenyl)ethenyl]-2-methylquinoline, C20H16BrNO, (II), and (E)-3-acetyl-2-methyl-4-{2-[4-(trifluoromethyl)phenyl]ethenyl}quinoline, C21H16F3NO, (III), are isomorphous and in each structure the molecules are linked by a single C-H...O hydrogen bond to form C(6) chains.	Hydrogen	337-345	small nucleolar RNA, H/ACA box 63	Homo sapiens	0-5
2271576-10	1990	By use of these values and steady-state kinetic data, the minimal rate for the hydrogen-transfer step is calculated to be approximately 75-fold faster than kcat for xanthine oxidase and approximately 10-fold faster than kcat for xanthine dehydrogenase.	Hydrogen	79-87	xanthine dehydrogenase	Gallus gallus	229-251
32160317-11	2020	The resulting p.Glu213Lys change disrupts hydrogen bonding with neighboring residues, resulting in severely reduced SQOR protein and enzyme activity, whereas sulfide generating enzyme levels were unchanged.	Hydrogen	42-50	sulfide quinone oxidoreductase	Homo sapiens	116-120
32652263-4	2020	Considering the structure natures of Ru1 and Ru2, conceivably besides electrostatic interaction, the forces stabilizing the triplex should also involve hydrophobic interaction and hydrogen binding.	Hydrogen	180-188	Scm like with four mbt domains 1	Homo sapiens	37-40
32652263-4	2020	Considering the structure natures of Ru1 and Ru2, conceivably besides electrostatic interaction, the forces stabilizing the triplex should also involve hydrophobic interaction and hydrogen binding.	Hydrogen	180-188	doublecortin domain containing 2	Homo sapiens	45-48
2261437-1	1990	The 600-MHz 1H NMR spectrum of the des-Val-Val mutant of human transforming growth factor alpha (TGF-alpha) was reassigned at pH = 6.3.	Hydrogen	12-14	transforming growth factor alpha	Homo sapiens	97-106
2207078-0	1990	Sequence-specific 1H NMR assignments and secondary structure in solution of Escherichia coli trp repressor.	Hydrogen	18-20	repressor	Escherichia coli	97-106
2386786-0	1990	Structure of the oligosaccharide of hen phosvitin as determined by two-dimensional 1H NMR of the intact glycoprotein.	Hydrogen	83-85	casein kinase 2 beta	Homo sapiens	40-49
32872860-6	2020	A comparison of the measured spectra with the predictions of anharmonic theory at the CCSD(T)/ANO1 level suggests that the predominant isomers formed by either argon tagging or para-hydrogen isolation are higher lying (+7.8 kcal mol-1), less symmetric isomers, and not the global minimum proton-bound dimer.	Hydrogen	182-190	anoctamin 1	Homo sapiens	94-98
2386786-1	1990	The major form of the oligosaccharide of hen phosvitin was studied with two-dimensional 1H NMR of the intact glycoprotein.	Hydrogen	88-90	casein kinase 2 beta	Homo sapiens	45-54
32581111-7	2020	A molecular dynamics simulation of RNA and mutagen (RTP) bound 3Dpol revealed that the T19 residue participates in a hydrogen bond network including D165 in motif F and R416 at the C-terminus of the FMDV 3Dpol and RNA template-primer.	Hydrogen	117-125	MORN repeat containing 4	Homo sapiens	52-55
2186803-8	1990	High-resolution 1H NMR of Zn(II)-GAL4(63) and Cd(II)-GAL4(63) show the two proteins to have almost identical conformations and to be present as monomers in solutions up to millimolar concentration.	Hydrogen	16-18	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	33-41
2111549-3	1990	Denaturation--refolding experiments demonstrated that Zn(II) is necessary for maintenance of the conformation of the DNA binding domain of GAL4, as judged on UV-CD and 1H-NMR measurements, as well as for specific DNA binding.	Hydrogen	168-170	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	139-143
32806738-4	2020	After activation under gaseous HF, MgF2-x(OH)x catalysts underwent a large decrease of both their surface area and their hydroxide, rates as shown by their 19F and 1H solid-state NMR spectra.	Hydrogen	164-166	signal transducer and activator of transcription 5A	Homo sapiens	35-38
32772893-9	2021	The fluorescence spectroscopy together with simulation through molecular docking method revealed that definitely hydrogen bonding plus van der Waals forces had major contributions to the stabilization of the myoglobin-glucose complex.	Hydrogen	113-121	myoglobin	Homo sapiens	208-217
2406138-2	1990	The conversion of dihydroneopterin triphosphate in the presence of 6-pyruvoyl tetrahydropterin synthase was followed by 1H-NMR spectroscopy.	Hydrogen	120-122	6-pyruvoyltetrahydropterin synthase	Homo sapiens	67-103
32527460-10	2020	Molecular docking studies suggested mode of interaction to HSP90 via hydrogen bonding.	Hydrogen	69-77	heat shock protein 90 alpha family class A member 1	Homo sapiens	59-64
2089966-4	1990	rCBF of cerebral cortex was measured 3 times per hr by H2-clearance with needle electrodes placed at different distances to the lesion during 6 hrs after induction of trauma.	Hydrogen	55-57	CCAAT/enhancer binding protein zeta	Rattus norvegicus	0-4
31526272-7	2020	The hydrogen bond analysis highlight higher structural stability and reduced flexibility of the loop regions of beta2m in presence of C1, C2, and C3.	Hydrogen	4-12	beta-2-microglobulin	Homo sapiens	112-118
31658877-4	2020	Protein structure networks and hydrogen bonds analysis demonstrated that active mutations broke the interaction between activation segments (residues 216-222) and C-helix (residues 105-121) in MEK1, leading to it transform inactive form to active form.	Hydrogen	31-39	mitogen-activated protein kinase kinase 1	Homo sapiens	193-197
31658877-5	2020	Moreover, hydrogen bond analysis and MM-PBSA calculation indicated that activating mutations decrease the binding affinity between MEK1 and inhibitor to reduce the inhibitory effect of inhibitors.	Hydrogen	10-18	mitogen-activated protein kinase kinase 1	Homo sapiens	131-135
29248720-4	2018	Results showed that the expression of Smurf1 increased in HG-induced GMCs, with a paramount upregulation at 1h.	Hydrogen	108-110	SMAD specific E3 ubiquitin protein ligase 1	Mus musculus	38-44
31938167-10	2018	Cox1 haplotypes H4, H5, and cytb haplotypes H2, H3, H4, and H5 are considered newly discovered gene haplotype sequences.	Hydrogen	16-18	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	0-4
31938167-10	2018	Cox1 haplotypes H4, H5, and cytb haplotypes H2, H3, H4, and H5 are considered newly discovered gene haplotype sequences.	Hydrogen	44-46	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	0-4
31938167-10	2018	Cox1 haplotypes H4, H5, and cytb haplotypes H2, H3, H4, and H5 are considered newly discovered gene haplotype sequences.	Hydrogen	52-54	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	0-4
31938167-10	2018	Cox1 haplotypes H4, H5, and cytb haplotypes H2, H3, H4, and H5 are considered newly discovered gene haplotype sequences.	Hydrogen	60-62	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	0-4
29337342-8	2018	Thermodynamic study showed that the actual value of  H &lt;0, but its absolute value greater than the corresponding value of T S, suggest a specific interaction between Trp-P-1 and these 3 polysaccharides, probably through the hydrogen bond and/or ion interaction.	Hydrogen	227-235	polycystin 1, transient receptor potential channel interacting	Homo sapiens	169-176
2217166-11	1990	In particular, Tyr-77 of the flap region of chymosin does not hydrogen bond to Trp-42 but protrudes out in the P1 pocket forming hydrophobic interactions with Phe-119 and Leu-32.	Hydrogen	62-70	chymosin	Bos taurus	44-52
27550844-1	2018	Variants in CLCN4, which encodes the chloride/hydrogen ion exchanger CIC-4 prominently expressed in brain, were recently described to cause X-linked intellectual disability and epilepsy.	Hydrogen	46-54	chloride voltage-gated channel 4	Homo sapiens	12-17
33767697-9	2021	Inhalation of hydrogen decreased tissue factor (TF) expression and MMP-9 activity, while Trx1 expression was increased in the lungs and serum of endotoxemia mice.	Hydrogen	14-22	matrix metallopeptidase 9	Mus musculus	67-72
29354815-2	2018	CoP nanoparticles anchored on N,P-dual-doped mesoporous graphene-like carbon (CoP@NPMG) acts as an outstanding bifunctional electrocatalyst for both the hydrogen evolution reaction and the oxygen evolution reaction over a wide pH range.	Hydrogen	153-161	caspase recruitment domain family member 16	Homo sapiens	0-3
29354815-2	2018	CoP nanoparticles anchored on N,P-dual-doped mesoporous graphene-like carbon (CoP@NPMG) acts as an outstanding bifunctional electrocatalyst for both the hydrogen evolution reaction and the oxygen evolution reaction over a wide pH range.	Hydrogen	153-161	caspase recruitment domain family member 16	Homo sapiens	78-81
32752079-13	2020	Finally, a simulation of molecular dynamics (MD) identified an MTX analog which exhibited strong affinity for WT- and MT-hDHFR, with stable RMSD, hydrogen bonds (H-bonds) in the binding site and the lowest MM/PBSA binding free energy.	Hydrogen	146-154	dihydrofolate reductase	Homo sapiens	121-126
33587625-8	2021	At 18.9 GPa, which was close to the upper pressure limit of HP2, the shortest dihydrogen bond decreased to ~1.65 A. Additionally, the X-ray diffraction results suggested another phase transition to the third high-pressure phase (HP3) at ~20 GPa.	Hydrogen	78-88	defensin alpha 3	Homo sapiens	229-232
32434320-4	2020	Careful mechanistic studies supported that NCS provided hydrogen abstractor "N-centered succinimidyl radical", which was responsible for the cleavage of benzylic C-H bond, relying on the reducing ability of Acr+-Mes.	Hydrogen	56-64	acrosin	Homo sapiens	207-210
29309143-3	2018	Structural characterization of this catalytically modified myoglobin variant (Mb NMH) revealed significant changes in the proximal pocket, including alterations to hydrogen-bonding interactions involving the prosthetic porphyrin cofactor.	Hydrogen	164-172	myoglobin	Homo sapiens	59-68
33032082-8	2021	Molecular docking studies indicate that all these DMPs bind well to NOD2 receptor with similar dock scores (binding energy) through a number of hydrogen bonding and hydrophobic/pi interactions with several crucial residues of the receptor.	Hydrogen	144-152	nucleotide binding oligomerization domain containing 2	Homo sapiens	68-72
29266945-0	2018	Activation of H2 by Gadolinium Cation (Gd+): Bond Energy of GdH+ and Mechanistic Insights from Guided Ion Beam and Theoretical Studies.	Hydrogen	14-16	glutamate dehydrogenase 1	Homo sapiens	60-63
32559102-3	2020	The observation is consistent with the presence of an endo and an exo isomeric variants of the complex predicted by electronic structure theory methods, and the endo isomer is stabilized by ~2 kcal/mol additionally owing to formation of a C-H   O and a C-H   pi type of weak hydrogen bonds between the two moieties.	Hydrogen	275-283	mannosidase endo-alpha	Homo sapiens	54-58
32559102-3	2020	The observation is consistent with the presence of an endo and an exo isomeric variants of the complex predicted by electronic structure theory methods, and the endo isomer is stabilized by ~2 kcal/mol additionally owing to formation of a C-H   O and a C-H   pi type of weak hydrogen bonds between the two moieties.	Hydrogen	275-283	mannosidase endo-alpha	Homo sapiens	161-165
29362238-6	2018	Searching for gene-wide episodic selection across the entire Laverania phylogeny, we found eight codons to be under positive selection, including three that correspond to contact residues known to form hydrogen bonds between P. falciparum RH5 and human basigin.	Hydrogen	202-210	basigin (Ok blood group)	Homo sapiens	253-260
32795580-7	2020	Docking results showed that the used polyphenols physically interacted with both hIAPP amyloidogenic region (residues Ser20-Ser29) and the non-amyloidogenic regions via hydrophobic and hydrogen interactions, thus reducing aggregation levels.	Hydrogen	185-193	islet amyloid polypeptide	Homo sapiens	81-86
29058435-1	2018	Low-cost transition-metal dichalcogenides (MS2) have attracted great interest as alternative catalysts for hydrogen evolution.	Hydrogen	107-115	MS2	Homo sapiens	43-46
29058435-2	2018	However, a significant challenge is the formation of sulfur-hydrogen bonds on MS2 (S-Hads), which will severely suppress hydrogen evolution reaction (HER).	Hydrogen	60-68	MS2	Homo sapiens	78-81
29058435-2	2018	However, a significant challenge is the formation of sulfur-hydrogen bonds on MS2 (S-Hads), which will severely suppress hydrogen evolution reaction (HER).	Hydrogen	121-129	MS2	Homo sapiens	78-81
32220819-4	2020	Such significant changes in the pyrolysis behaviors of the beta-5 lignin dimer after the introduction of CNT-NH2 were considered to be mainly caused by hydrogen-bond formations between -NH2 and the dimeric feedstock/products, in addition to the pi-pi stacking between CNT and aromatic rings.	Hydrogen	152-160	immunoglobulin kappa variable 2D-26	Homo sapiens	59-65
32350570-0	2020	Hydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	70-75
32350570-15	2020	Hydrogen increased Nrf2 expression and inhibited the SAE-induced expression of NLRP3, caspase-1, cytokines IL-1beta and IL-18, neuronal apoptosis, and mitochondrial dysfunction in WT mice but not Nrf2 KO mice.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	79-84
32350570-15	2020	Hydrogen increased Nrf2 expression and inhibited the SAE-induced expression of NLRP3, caspase-1, cytokines IL-1beta and IL-18, neuronal apoptosis, and mitochondrial dysfunction in WT mice but not Nrf2 KO mice.	Hydrogen	0-8	interleukin 1 alpha	Mus musculus	107-115
32350570-17	2020	Hydrogen alleviated inflammation, neuronal apoptosis and mitochondrial dysfunction via inhibiting Nrf2-mediated NLRP3 pathway.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	112-117
29313158-1	2018	MP2/aug-cc-pVTZ calculations were performed for complexes linked by hydrogen bonds.	Hydrogen	68-76	tryptase pseudogene 1	Homo sapiens	0-3
24140414-0	2013	Sodium-hydrogen exchangers (NHE) in human cardiovascular diseases: interfering strategies and their therapeutic applications.	Hydrogen	7-15	solute carrier family 9 member C1	Homo sapiens	28-31
29845539-6	2018	These crystal structures and hydrogen-deuterium exchange mass spectrometry of the murine ER alpha glucosidase II heterodimer uncover the quaternary arrangement of the enzyme"s alpha- and beta-subunits, and suggest a conformational rearrangement of ER alpha-Glu II upon association of the enzyme with client glycoproteins.	Hydrogen	29-37	estrogen receptor 1 (alpha)	Mus musculus	89-97
29763919-15	2018	The expression levels of Cox8b, Cox6a2, Cox7a1, Hspb7, and Atp2a1 were inhibited by hydrogen treatment.	Hydrogen	84-92	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	Mus musculus	59-65
32428055-2	2020	PCDTBT/PC60BM nanohybrid showed a high hydrogen evolution rate of 105.2 mmol g-1 h-1 under visible light (lambda > 420 nm).	Hydrogen	39-47	H1.5 linker histone, cluster member	Homo sapiens	81-84
24140414-1	2013	Sodium-hydrogen exchangers (NHE) are among the main regulators of cell volume and intracellular concentration of hydrogen and sodium ions.	Hydrogen	7-15	solute carrier family 9 member C1	Homo sapiens	28-31
29763919-19	2018	Cox8b, Cox6a2, Cox7a1, Hspb7, and Atp2a1 were identified as potential target genes of hydrogen treatment.	Hydrogen	86-94	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	Mus musculus	34-40
34757057-0	2022	Dynamics and Conformational Changes in Human NEIL2 DNA Glycosylase Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry.	Hydrogen	79-87	nei like DNA glycosylase 2	Homo sapiens	45-50
27829348-9	2018	MD simulation of ligand 5 showed that the ligand-SK1 complex reached equilibrium with favorable hydrogen bonding and hydrophobic interactions.	Hydrogen	96-104	sphingosine kinase 1	Homo sapiens	49-52
32412761-2	2020	Mass spectrometry and the 1H NMR chemical shift reveal that CAGE-oct is a dynamic system, with metathesis (the exchange of interacting ions) and hydrogen exchange occurring between hydrogen-bonded/ionic complexes such as [(choline)(geranate)(H)(octanoate)], [(choline)(octanoate)2(H)] and [(choline)(geranate)2(H)].	Hydrogen	26-28	plexin A2	Homo sapiens	65-68
32412761-2	2020	Mass spectrometry and the 1H NMR chemical shift reveal that CAGE-oct is a dynamic system, with metathesis (the exchange of interacting ions) and hydrogen exchange occurring between hydrogen-bonded/ionic complexes such as [(choline)(geranate)(H)(octanoate)], [(choline)(octanoate)2(H)] and [(choline)(geranate)2(H)].	Hydrogen	145-153	plexin A2	Homo sapiens	65-68
32412761-2	2020	Mass spectrometry and the 1H NMR chemical shift reveal that CAGE-oct is a dynamic system, with metathesis (the exchange of interacting ions) and hydrogen exchange occurring between hydrogen-bonded/ionic complexes such as [(choline)(geranate)(H)(octanoate)], [(choline)(octanoate)2(H)] and [(choline)(geranate)2(H)].	Hydrogen	181-189	plexin A2	Homo sapiens	65-68
34757057-5	2022	Here we analyze the conformational dynamics of free hNEIL2 using a combination of hydrogen/deuterium exchange mass spectrometry, homology modeling and molecular dynamics simulations.	Hydrogen	82-90	nei like DNA glycosylase 2	Homo sapiens	52-58
34928619-1	2022	Local stretching force constants derived from periodic local vibrational modes at the vdW-DF2 density functional level have been employed to quantify the intrinsic hydrogen bond strength of 16 ice polymorphs, ices Ih, II, III, IV, V, VI, VII, VIII, IX, XI, XII, XIII, XIV, XV, XVII, and XIX, that are stable under ambient to elevated pressures.	Hydrogen	164-172	cytochrome c oxidase subunit 8A	Homo sapiens	243-247
32193123-6	2020	The highly active n-Al/CaO interacted with water as the hydrogen donor to promote the reductive dechlorination process.	Hydrogen	56-64	mummy	Drosophila melanogaster	23-26
29202400-5	2018	The binding mode of 10s revealed that the major interactions with MD2 were established via two key hydrogen bonds and hydrophobic interactions.	Hydrogen	99-107	lymphocyte antigen 96	Mus musculus	66-69
32463675-6	2020	The fabricated CoP/SPNF electrocatalyst exhibits impressive bifunctional performance for the hydrogen evolution reaction (HER, overpotential of 45 mV at 10 mA cm-2) and oxygen evolution reaction (OER, overpotential of 215 mV at 80 mA cm-2) and consequently enables efficient electrolytic water splitting with a low cell voltage of 1.547 V at 30 mA cm-2 and a prominent durability.	Hydrogen	93-101	caspase recruitment domain family member 16	Homo sapiens	15-18
34738622-7	2022	Molecular docking analysis confirmed that VDa, VLe and VLi formed hydrogen bonds with the FERM domain of JAK2 protein.	Hydrogen	66-74	Janus kinase 2	Homo sapiens	105-109
32303640-7	2020	A multipronged systematic analysis of the reaction rates in the OADHc pathway, supplemented with results from chemical cross-linking and hydrogen-deuterium exchange MS, revealed that the c.2185G A DHTKD1 mutation affects E1a-E2o assembly, leading to impaired channeling of OADHc intermediates.	Hydrogen	137-145	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	197-203
28993251-6	2018	Neonatal HI reshaped the postsynaptic GluN2B interactome by recruiting new proteins, including multiple kinases, into the complexes; and modifying the existing associations within 1h of reperfusion.	Hydrogen	180-182	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	38-44
29377356-2	2018	OBJECTIVE: Determine whether BRD bacterial and viral pathogens are susceptible to the lactoperoxidase/hydrogen peroxide/iodide (LPO/H2 O2 /I- ) system in vitro and to determine whether the oral administration of sodium iodide (NaI) could achieve sufficient concentrations of iodine (I) in the respiratory secretions of weaned beef calves to inactivate these pathogens in vivo.	Hydrogen	132-134	lactoperoxidase	Bos taurus	128-131
34957700-0	2022	Amorphous/Crystalline Heterophase Ruthenium Nanosheets for pH-Universal Hydrogen Evolution.	Hydrogen	72-80	phenylalanine hydroxylase	Homo sapiens	59-61
32366133-5	2020	1H-NMR was used to determine the quantity of hydroxyl group in the PSA.	Hydrogen	0-2	aminopeptidase puromycin sensitive	Homo sapiens	67-70
30930589-3	2018	However, increasing the partial pressure of hydrogen reduces the population of PdCx with the concomitant formation of a beta-PdHx phase up to the surface, which is accompanied by a lattice expansion, allowing the participation of more active bulk hydrogen which is responsible for the unselective total alkyne hydrogenation.	Hydrogen	44-52	pyruvate dehydrogenase complex component X	Homo sapiens	125-129
32105905-7	2020	C2-10%MoS2-x@CdS presented a high H2 evolution rate of 61,494 mumol h-1 g-1 under visible light irrigation (lambda >= 420 nm), which is 1.98 times and 158 times higher than that of sample without S-vacancies (10%MoS2@CdS) and pure CdS, respectively.	Hydrogen	34-36	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
32105905-7	2020	C2-10%MoS2-x@CdS presented a high H2 evolution rate of 61,494 mumol h-1 g-1 under visible light irrigation (lambda >= 420 nm), which is 1.98 times and 158 times higher than that of sample without S-vacancies (10%MoS2@CdS) and pure CdS, respectively.	Hydrogen	34-36	CDP-diacylglycerol synthase 1	Homo sapiens	217-220
32105905-7	2020	C2-10%MoS2-x@CdS presented a high H2 evolution rate of 61,494 mumol h-1 g-1 under visible light irrigation (lambda >= 420 nm), which is 1.98 times and 158 times higher than that of sample without S-vacancies (10%MoS2@CdS) and pure CdS, respectively.	Hydrogen	34-36	CDP-diacylglycerol synthase 1	Homo sapiens	217-220
34957700-6	2022	Accordingly, electrochemical measurements demonstrate that the amorphous/crystalline heterophase Ru exhibits improved hydrogen evolution efficiency as compared with pure amorphous Ru and pure crystalline Ru, at pH-universal conditions.	Hydrogen	118-126	phenylalanine hydroxylase	Homo sapiens	211-213
29172509-3	2017	Sequential capture of O(3P) and HCN leads to the production of a hydrogen-bound O-HCN complex in a 3Sigma electronic state, as determined via comparisons of experimental and theoretical rovibrational Stark spectroscopy.	Hydrogen	65-73	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	32-35
34904832-4	2021	The obtained results revealed that all inhibitors interacting within the PLpro active site are mostly driven by vdW interactions, and the hydrogen bond formation in residues G163 and G271 with peptidomimetics and the Q269 residue with naphthalene-based inhibitors was essential for stabilizing the protein-ligand complexes.	Hydrogen	138-146	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	73-78
29172509-3	2017	Sequential capture of O(3P) and HCN leads to the production of a hydrogen-bound O-HCN complex in a 3Sigma electronic state, as determined via comparisons of experimental and theoretical rovibrational Stark spectroscopy.	Hydrogen	65-73	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	82-85
29172509-4	2017	Ab initio computations of the three lowest lying intermolecular potential energy surfaces reveal two isomers, the hydrogen-bound (3Sigma) O-HCN complex and a nitrogen-bound (3Pi) HCN-O complex, lying 323 cm-1 higher in energy.	Hydrogen	114-122	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	140-143
29172509-4	2017	Ab initio computations of the three lowest lying intermolecular potential energy surfaces reveal two isomers, the hydrogen-bound (3Sigma) O-HCN complex and a nitrogen-bound (3Pi) HCN-O complex, lying 323 cm-1 higher in energy.	Hydrogen	114-122	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	179-182
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Hydrogen	120-128	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	28-33
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Hydrogen	120-128	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Hydrogen	120-128	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Hydrogen	120-128	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
32073192-9	2020	Molecular docking analysis demonstrates the molecular shifts in hydrogen and ionic bonds and Van der waals bonding properties which have further caused the differences in the binding energy of LDLR-LDLRAP1 proteins.	Hydrogen	64-72	low density lipoprotein receptor	Homo sapiens	193-197
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Hydrogen	120-128	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
34874028-0	2021	MOF-derived ruthenium-doped amorphous molybdenum dioxide hybrid for highly efficient hydrogen evolution reaction in alkaline media.	Hydrogen	85-93	lysine acetyltransferase 8	Homo sapiens	0-3
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Hydrogen	120-128	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Hydrogen	120-128	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Hydrogen	120-128	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
32356648-8	2020	In this study, hydrogen gas (H2) is chosen as a target gas since it is a common energy source in fuel cell applications and by-product in chemical reactions.	Hydrogen	15-23	gastrin	Homo sapiens	24-27
32356648-8	2020	In this study, hydrogen gas (H2) is chosen as a target gas since it is a common energy source in fuel cell applications and by-product in chemical reactions.	Hydrogen	15-23	gastrin	Homo sapiens	55-58
32356648-11	2020	Furthermore, the sensors detect ppm levels of hydrogen gas even in the presence of high humidity that typically hinders gas sensor performance.	Hydrogen	46-54	gastrin	Homo sapiens	55-58
32356648-11	2020	Furthermore, the sensors detect ppm levels of hydrogen gas even in the presence of high humidity that typically hinders gas sensor performance.	Hydrogen	46-54	gastrin	Homo sapiens	120-123
32040263-5	2020	The related reaction mechanism was proposed as CO 2 +2Li+2H +  HCOOH+2Li + .	Hydrogen	57-59	complement C2	Homo sapiens	47-51
28962916-7	2017	The phosphorylation levels of ezrin (Thr567), which is suggested to act as a signaling bridge between the cellular membrane receptors and actin cytoskeleton, were strongly enhanced by IGF-I at both 1h and 24h (p &lt; 0.05; p &lt; 0.01).	Hydrogen	198-200	ezrin	Homo sapiens	30-35
34930785-7	2022	Docking simulation indicated that, in the formation of M1 and M2, there would be hydrogen bonding and/or electrostatic interactions between the pyrimidine and sulfonamide moieties of DS-1971a and amino acid residues Ser100, Ile102, Ile106, Thr107, and Asn217 in CYP2C8, and that the cyclohexane ring of DS-1971a would be located near the heme iron of CYP2C8.	Hydrogen	81-89	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	351-357
28482648-6	2017	The RTA approach developed here can be used as a suitable hydrogenation process for TiO2 nanorods/FTO system for important applications such as photocatalysis, hydrogen generation from water splitting and solar energy conversion.	Hydrogen	58-66	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	98-101
28985057-3	2017	SB1-SB4 are linked through C-H   O hydrogen bonding interactions to construct supramolecular metal-organic frameworks (SMOFs): namely, SMOFSB1-SMOFSB4.	Hydrogen	35-43	SH3KBP1 binding protein 1	Homo sapiens	0-3
32006472-7	2020	Our experimental and computational results showed that flavonoid aglycones interacted with OATP1B1 much stronger than their glycosides such as 3-O- and 7-O-glycosides as bulky hydrophilic and hydrogen-bond forming substituents at C-3 and C-7 positions on rings A and C were unfavorable for their binding.	Hydrogen	192-200	solute carrier organic anion transporter family member 1B1	Homo sapiens	91-98
28321784-3	2017	At the ratio of 5:5, HRT was reduced from 8 to 0.5 h. The maximum hydrogen yield of 0.120 mmol H2 g COD-1 was observed at the CW/CG ratio of 5:1.	Hydrogen	66-74	component of oligomeric golgi complex 4	Homo sapiens	100-105
34773716-10	2021	Finally, miconazole and niacin were predicted as potential therapeutic drugs for gastric adenocarcinoma that bond stably with NOS3 and NNMT through hydrogen interactions.	Hydrogen	148-156	nicotinamide N-methyltransferase	Homo sapiens	135-139
28321784-3	2017	At the ratio of 5:5, HRT was reduced from 8 to 0.5 h. The maximum hydrogen yield of 0.120 mmol H2 g COD-1 was observed at the CW/CG ratio of 5:1.	Hydrogen	95-97	component of oligomeric golgi complex 4	Homo sapiens	100-105
28722183-4	2017	These PGII -like helices form hexagonal bundles which appear to fulfill the criterion of a (largely) saturated hydrogen-bonding network of the main-chain groups and therefore may be regarded in this sense as a new secondary structure element.	Hydrogen	111-119	decorin	Homo sapiens	6-10
34700041-5	2021	Taking advantage of fast hydrogen exchange (HX) between H2O2 and water permits the use of very short interscan delays, greatly increasing sensitivity.	Hydrogen	25-33	hemopexin	Homo sapiens	44-46
28722183-7	2017	In both cases, all main chain NH and CO groups of the central PGII -helix are saturated by either intra- or intermolecular hydrogen-bonds, resulting in a self-contained hydrogen-bonding network.	Hydrogen	123-131	decorin	Homo sapiens	62-66
28722183-7	2017	In both cases, all main chain NH and CO groups of the central PGII -helix are saturated by either intra- or intermolecular hydrogen-bonds, resulting in a self-contained hydrogen-bonding network.	Hydrogen	169-177	decorin	Homo sapiens	62-66
28807355-11	2017	Moreover, treatment with H2-rich water decreased the levels of oxidative DNA damage markers such as phosphorylated histone H2AX and 8-hydroxy-2"-deoxyguanosine, and senescence markers such as cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase inhibitor 1, and beta-galactosidase in the CS-exposed mice.	Hydrogen	25-27	galactosidase, beta 1	Mus musculus	271-289
28919439-3	2017	We characterized the structure of the ScR2TP complex made up of two AAA+ ATPases, Rvb1/2p, and two Hsp90 binding proteins, Tah1p and Pih1p, and its interaction with the snoRNP protein Nop58p by a combination of analytical ultracentrifugation, isothermal titration calorimetry, chemical crosslinking, hydrogen-deuterium exchange, and cryoelectron microscopy methods.	Hydrogen	300-308	RNA-processing protein NOP58	Saccharomyces cerevisiae S288C	184-190
28549396-9	2017	The concentrations of HMGB-1 and IL-10 in the hydrogen-saturated saline group were significantly higher than in those in the normal saline group immediately and at 7 d after noise exposure.	Hydrogen	46-54	interleukin-10	Cavia porcellus	33-38
34884798-5	2021	Our pharmacophore model illuminates the existence of two hydrogen-bond acceptors (2.62 A and 4.79 A) and two hydrogen-bond donors (5.56 A and 7.68 A), respectively, from a hydrophobic group within the chemical scaffold, which may enhance the liability (IC50) of a compound for IP3R inhibition.	Hydrogen	57-65	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	277-281
28275980-0	2017	1H, 15N, 13C resonance assignment of plant dehydrin early response to dehydration 10 (ERD10).	Hydrogen	0-2	Dehydrin family protein	Arabidopsis thaliana	86-91
34884798-5	2021	Our pharmacophore model illuminates the existence of two hydrogen-bond acceptors (2.62 A and 4.79 A) and two hydrogen-bond donors (5.56 A and 7.68 A), respectively, from a hydrophobic group within the chemical scaffold, which may enhance the liability (IC50) of a compound for IP3R inhibition.	Hydrogen	109-117	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	277-281
34884798-6	2021	Moreover, our GRIND model (PLS: Q2 = 0.70 and R2 = 0.72) further strengthens the identified pharmacophore features of IP3R modulators by probing the presence of complementary hydrogen-bond donor and hydrogen-bond acceptor hotspots at a distance of 7.6-8.0 A and 6.8-7.2 A, respectively, from a hydrophobic hotspot at the virtual receptor site (VRS).	Hydrogen	175-183	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	118-122
34884798-6	2021	Moreover, our GRIND model (PLS: Q2 = 0.70 and R2 = 0.72) further strengthens the identified pharmacophore features of IP3R modulators by probing the presence of complementary hydrogen-bond donor and hydrogen-bond acceptor hotspots at a distance of 7.6-8.0 A and 6.8-7.2 A, respectively, from a hydrophobic hotspot at the virtual receptor site (VRS).	Hydrogen	199-207	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	118-122
28841462-0	2017	A theoretical survey of substituent effects on the properties of pnicogen and hydrogen bonds in cationic complexes of PH4+ with substituted benzonitrile.	Hydrogen	78-86	prolyl 4-hydroxylase, transmembrane	Homo sapiens	118-121
34884494-5	2021	The mechanism by which these drugs exert their cardioprotective effects is unknown, although recent studies have shown that cardiovascular homeostasis occurs through the interplay of the sodium-hydrogen exchangers (NHE), specifically NHE1 and NHE3, with SGLT2i.	Hydrogen	194-202	solute carrier family 9 member C1	Homo sapiens	215-218
34699241-0	2021	The Protective Effect of Basic Fibroblast Growth Factor in Intestine of db/db Mice: A 1H NMR-Based Metabolomics Investigation.	Hydrogen	86-88	fibroblast growth factor 2	Mus musculus	25-55
28719182-2	2017	We show that using the tip of a noncontact atomic force microscope (NC-AFM), a single hydrogen atom could be vertically manipulated.	Hydrogen	86-94	TOR signaling pathway regulator	Homo sapiens	23-26
28719182-3	2017	When applying a localized electronic excitation, a single hydrogen atom is desorbed from the hydrogen-passivated surface and can be transferred to the tip apex, as evidenced from a unique signature in frequency shift curves.	Hydrogen	58-66	TOR signaling pathway regulator	Homo sapiens	151-154
28719182-3	2017	When applying a localized electronic excitation, a single hydrogen atom is desorbed from the hydrogen-passivated surface and can be transferred to the tip apex, as evidenced from a unique signature in frequency shift curves.	Hydrogen	93-101	TOR signaling pathway regulator	Homo sapiens	151-154
28719182-4	2017	In the absence of tunnel electrons and electric field in the scanning probe microscope junction at 0 V, the hydrogen atom at the tip apex is brought very close to a silicon dangling bond, inducing the mechanical formation of a silicon-hydrogen covalent bond and the passivation of the dangling bond.	Hydrogen	108-116	TOR signaling pathway regulator	Homo sapiens	129-132
28719182-4	2017	In the absence of tunnel electrons and electric field in the scanning probe microscope junction at 0 V, the hydrogen atom at the tip apex is brought very close to a silicon dangling bond, inducing the mechanical formation of a silicon-hydrogen covalent bond and the passivation of the dangling bond.	Hydrogen	235-243	TOR signaling pathway regulator	Homo sapiens	129-132
28719182-5	2017	The functionalized tip was used to characterize silicon dangling bonds on the hydrogen-silicon surface, which was shown to enhance the scanning tunneling microscope contrast, and allowed NC-AFM imaging with atomic and chemical bond contrasts.	Hydrogen	78-86	TOR signaling pathway regulator	Homo sapiens	19-22
28724631-5	2017	To this end, using differential scanning fluorimetry and hydrogen-deuterium exchange mass spectrometry, we show here that a lower stability and greater dynamic nature of the Axl kinase domain may account for its poor crystallizability.	Hydrogen	57-65	AXL receptor tyrosine kinase	Homo sapiens	174-177
34662099-12	2021	The observed switch in substrate specificity of the enzyme is consistent with this result if the hydrogen bonding to the proximal peroxo oxygen is necessary for a proposed nucleophilic peroxoanion-mediated mechanism for CYP17A1 in carbon-carbon bond scission.	Hydrogen	97-105	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	220-227
28520164-5	2017	In fact, TMC/graphene ensembles are photocatalytically active and superior as compared to intact TMCs analogues, when examined toward photocatalytic H2 evolution, dye degradation and redox transformations of organic compounds.	Hydrogen	149-151	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	9-12
34561943-0	2021	Highly Controllable Hierarchically Porous Ag/Ag2 S Heterostructure by Cation Exchange for Efficient Hydrogen Evolution.	Hydrogen	100-108	angiotensin II receptor type 1	Homo sapiens	45-50
28928375-0	2017	An efficient Co3S4/CoP hybrid catalyst for electrocatalytic hydrogen evolution.	Hydrogen	60-68	caspase recruitment domain family member 16	Homo sapiens	19-22
28928375-6	2017	These results obtained in this study indicate that the Co3S4/CoP hybrid nanorod is promising replacement to the Pt-based catalysts for H2 production.	Hydrogen	135-137	caspase recruitment domain family member 16	Homo sapiens	61-64
34647740-0	2021	Calorimetric Investigation of Hydrogen-Atom Sublattice Transitions in the Ice VI/XV/XIX Trio.	Hydrogen	30-38	trio Rho guanine nucleotide exchange factor	Homo sapiens	88-92
28872070-0	2017	Hydrogen-bonded structures and interaction energies in two forms of the SGLT-2 inhibitor sotagliflozin.	Hydrogen	0-8	solute carrier family 5 member 2	Homo sapiens	72-78
28768320-4	2017	Instead, in the kidneys, SGLT2 functionally interacts with the sodium-hydrogen exchanger, which is responsible for the majority of sodium tubular reuptake following filtration.	Hydrogen	70-78	solute carrier family 5 member 2	Homo sapiens	25-30
28768320-9	2017	Conclusions and Relevance: The benefits of SGLT2 inhibitors in heart failure may be mediated by the inhibition of sodium-hydrogen exchange rather than the effect on glucose reabsorption.	Hydrogen	121-129	solute carrier family 5 member 2	Homo sapiens	43-48
34617884-3	2021	We have shown that enhancing endosomal acidification by inhibiting the EE-specific sodium-hydrogen exchanger 6 (NHE6) restores vesicular trafficking and normalizes synaptic homeostasis.	Hydrogen	90-98	solute carrier family 9 (sodium/hydrogen exchanger), member 6	Mus musculus	112-116
28820214-7	2017	Subsequently, [Cp2*Fe(IV)(H)]+ spontaneously undergoes a chemical reaction in the oil phase to evolve hydrogen gas (H2) and regenerate [Cp2*Fe(III)]+, whereupon this catalytic Electrochemical, Chemical, Chemical (ECC") cycle is repeated.	Hydrogen	102-110	ceruloplasmin	Homo sapiens	15-18
28820214-7	2017	Subsequently, [Cp2*Fe(IV)(H)]+ spontaneously undergoes a chemical reaction in the oil phase to evolve hydrogen gas (H2) and regenerate [Cp2*Fe(III)]+, whereupon this catalytic Electrochemical, Chemical, Chemical (ECC") cycle is repeated.	Hydrogen	102-110	ceruloplasmin	Homo sapiens	136-139
28820214-7	2017	Subsequently, [Cp2*Fe(IV)(H)]+ spontaneously undergoes a chemical reaction in the oil phase to evolve hydrogen gas (H2) and regenerate [Cp2*Fe(III)]+, whereupon this catalytic Electrochemical, Chemical, Chemical (ECC") cycle is repeated.	Hydrogen	116-118	ceruloplasmin	Homo sapiens	15-18
28820214-7	2017	Subsequently, [Cp2*Fe(IV)(H)]+ spontaneously undergoes a chemical reaction in the oil phase to evolve hydrogen gas (H2) and regenerate [Cp2*Fe(III)]+, whereupon this catalytic Electrochemical, Chemical, Chemical (ECC") cycle is repeated.	Hydrogen	116-118	ceruloplasmin	Homo sapiens	136-139
34608916-0	2021	Improved hydrogen evolution with SnS2 quantum dot-incorporated black Si photocathode.	Hydrogen	9-17	sodium voltage-gated channel alpha subunit 11	Homo sapiens	33-37
34608916-6	2021	As a result, the thus-designed SnS2/bSi reveals an exceptional PEC-HER activity with a positive onset potential of 0.235 V vs. reversible hydrogen electrode (RHE), a high photocurrent of 1.23 mA cm-2 at 0 V vs. RHE, and long-term stability.	Hydrogen	138-146	sodium voltage-gated channel alpha subunit 11	Homo sapiens	31-35
28691816-5	2017	Furthermore, more water molecules are considered near the carbonyl group and hydroxyl group related to the intramolecular proton transfer to form intermolecular hydrated hydrogen bond with ALR for clarifying the block mechanism of water on ESIPT.	Hydrogen	170-178	growth factor, augmenter of liver regeneration	Homo sapiens	189-192
34350671-5	2021	The strong interaction of Pt and zeolite in Pt@beta is effective to promote the spillover of active hydrogen, giving an excellent activity and stability for hydrodeoxygenation reaction.	Hydrogen	100-108	pre T cell antigen receptor alpha	Homo sapiens	44-51
28691816-7	2017	The results show that the interrupt role of water on the ESIPT originated from the forming of hydrated hydrogen bond between the carbonyl oxygen atom and the water molecule, which weakens the intramolecular hydrogen bond associated with proton transfer, increases the energy barrier of ESIPT, and thus precludes the transition of ALR-E to ALR-K in the excited state.	Hydrogen	103-111	growth factor, augmenter of liver regeneration	Homo sapiens	330-333
28691816-7	2017	The results show that the interrupt role of water on the ESIPT originated from the forming of hydrated hydrogen bond between the carbonyl oxygen atom and the water molecule, which weakens the intramolecular hydrogen bond associated with proton transfer, increases the energy barrier of ESIPT, and thus precludes the transition of ALR-E to ALR-K in the excited state.	Hydrogen	103-111	growth factor, augmenter of liver regeneration	Homo sapiens	339-342
28691816-7	2017	The results show that the interrupt role of water on the ESIPT originated from the forming of hydrated hydrogen bond between the carbonyl oxygen atom and the water molecule, which weakens the intramolecular hydrogen bond associated with proton transfer, increases the energy barrier of ESIPT, and thus precludes the transition of ALR-E to ALR-K in the excited state.	Hydrogen	207-215	growth factor, augmenter of liver regeneration	Homo sapiens	330-333
28691816-7	2017	The results show that the interrupt role of water on the ESIPT originated from the forming of hydrated hydrogen bond between the carbonyl oxygen atom and the water molecule, which weakens the intramolecular hydrogen bond associated with proton transfer, increases the energy barrier of ESIPT, and thus precludes the transition of ALR-E to ALR-K in the excited state.	Hydrogen	207-215	growth factor, augmenter of liver regeneration	Homo sapiens	339-342
28371750-4	2017	This study demonstrated that after the addition of Na2S solution into culture medium, HS- was transiently generated and disappeared immediately through the reaction between HS- and cystine to form cysteine persulfides and polysulfides in the culture medium (bound sulfur mixture: BS-Mix).	Hydrogen	86-88	Mix paired-like homeobox	Homo sapiens	283-286
28371750-4	2017	This study demonstrated that after the addition of Na2S solution into culture medium, HS- was transiently generated and disappeared immediately through the reaction between HS- and cystine to form cysteine persulfides and polysulfides in the culture medium (bound sulfur mixture: BS-Mix).	Hydrogen	86-89	Mix paired-like homeobox	Homo sapiens	283-286
34428371-10	2021	The DFT results reveal that N487, Q493, Y449, T500, G496, G446, and G502 in RBD of SARS2 form pairs via specific hydrogen bonding with Q24, H34, E35, D38, Y41, Q42, and K353 in ACE2.	Hydrogen	113-121	angiotensin converting enzyme 2	Homo sapiens	177-181
28440616-7	2017	Hydrogen/deuterium exchange mass spectrometry demonstrated that the deuterium-incorporation pattern of compound 2 overlapped with that of an allosteric pan-eIF4A inhibitor, hippuristanol, suggesting that compound 2 binds to an allosteric region on eIF4A3.	Hydrogen	0-8	eukaryotic translation initiation factor 4A2	Homo sapiens	156-161
34507982-6	2021	Here, we investigated the mechanism of arrestin-2 scaffolding of cRaf, MEK1, and ERK2 using hydrogen/deuterium exchange-mass spectrometry, tryptophan-induced bimane fluorescence quenching, and NMR.	Hydrogen	92-100	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	65-69
28671221-3	2017	In sodium borate buffer at pH 9.20, this complex decomposed to give a Cu(OH)2/Cu2O-based thin film on FTO that catalyzes both hydrogen production and water oxidation.	Hydrogen	126-134	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	102-105
34518836-6	2021	Molecular dynamics simulations were performed using NAMD to investigate the hydrogen bonds between S proteins and hACE2.	Hydrogen	76-84	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	99-100
28621934-5	2017	Although the crystal structure of the TQOPEN-Cd2+ complex exhibits a six-coordinate metal center, in which one quinoline weakly interacts with the Cd center (Cd   Nquinoline = 3.303(3) A), a 1H NMR study at 233 K suggests that all quinolines interact with the Cd center to form a symmetrical seven-coordinate structure in solution.	Hydrogen	191-193	CD2 molecule	Homo sapiens	45-48
28482566-10	2017	1h UV treated LDEDDS removed up to 62% of cancer secreted epidermal growth factor (EGF), a model hydrophobic secretion in 96h.	Hydrogen	0-2	epidermal growth factor	Homo sapiens	58-81
34518836-6	2021	Molecular dynamics simulations were performed using NAMD to investigate the hydrogen bonds between S proteins and hACE2.	Hydrogen	76-84	angiotensin converting enzyme 2	Homo sapiens	114-119
28482566-10	2017	1h UV treated LDEDDS removed up to 62% of cancer secreted epidermal growth factor (EGF), a model hydrophobic secretion in 96h.	Hydrogen	0-2	epidermal growth factor	Homo sapiens	83-86
34518836-7	2021	From the MD simulations it was found that SARS-CoV-2 has four pairsof essential hydrogenbonds (high occupancy, >80%), while SARS-CoV has three pairs, which indicates the SARS-CoV-2 S protein has relatively more robust binding strategy than SARS-CoVS protein.Four key residues forming essential hydrogen bonds from SARS-CoV-2 are identified, which are potential drug targets for COVID-19 treatments.	Hydrogen	294-302	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	181-182
32296800-0	2020	Multi-channel V-doped CoP hollow nanofibers as high-performance hydrogen evolution reaction electrocatalysts.	Hydrogen	64-72	caspase recruitment domain family member 16	Homo sapiens	22-25
34494836-4	2021	The loop region of LRR12 (residues 323-355), which protrudes from the dsRNA binding TLR3 lateral surface was found to be vital for interacting with dsRNA via the formation of hydrogen bonds.	Hydrogen	175-183	toll like receptor 3	Homo sapiens	84-88
31880358-3	2020	Using conventional QTAIM, the shifting of the C C and C H bond critical points (BCPs) demonstrates polarization through an interchange in the size of the atoms involved in a bond, since a BCP is located on the boundary between a pair of bonded atoms.	Hydrogen	54-57	opsin 1, short wave sensitive	Homo sapiens	80-83
28604880-5	2017	The Pd : PPh3 : OH2 1 : 1 : 1 reaction of the polymer produces cis-[Pd(CH2SO2C6H4Me)2(OH2)(PPh3)], which isomerizes to trans-[Pd(CH2SO2C6H4Me)2(OH2)(PPh3)], with water O-coordinated to Pd and making hydrogen bonds to the two SO2 groups as seen in its X-ray structure.	Hydrogen	199-207	protein phosphatase 4 catalytic subunit	Homo sapiens	9-13
28604880-5	2017	The Pd : PPh3 : OH2 1 : 1 : 1 reaction of the polymer produces cis-[Pd(CH2SO2C6H4Me)2(OH2)(PPh3)], which isomerizes to trans-[Pd(CH2SO2C6H4Me)2(OH2)(PPh3)], with water O-coordinated to Pd and making hydrogen bonds to the two SO2 groups as seen in its X-ray structure.	Hydrogen	199-207	protein phosphatase 4 catalytic subunit	Homo sapiens	91-95
28604880-5	2017	The Pd : PPh3 : OH2 1 : 1 : 1 reaction of the polymer produces cis-[Pd(CH2SO2C6H4Me)2(OH2)(PPh3)], which isomerizes to trans-[Pd(CH2SO2C6H4Me)2(OH2)(PPh3)], with water O-coordinated to Pd and making hydrogen bonds to the two SO2 groups as seen in its X-ray structure.	Hydrogen	199-207	protein phosphatase 4 catalytic subunit	Homo sapiens	91-95
28272630-1	2017	The photocatalytic production of molecular hydrogen (H2) on ternary composites of Pt, CdS, and sodium trititanate nanotubes (NaxH2-xTi3O7, TNTs) is examined in an aqueous 2-propanol (IPA) solution (typically 5 vol%) at a circum-neutral pH under visible light (lambda &gt; 420 nm).	Hydrogen	43-51	CDP-diacylglycerol synthase 1	Homo sapiens	86-89
28272630-1	2017	The photocatalytic production of molecular hydrogen (H2) on ternary composites of Pt, CdS, and sodium trititanate nanotubes (NaxH2-xTi3O7, TNTs) is examined in an aqueous 2-propanol (IPA) solution (typically 5 vol%) at a circum-neutral pH under visible light (lambda &gt; 420 nm).	Hydrogen	53-55	CDP-diacylglycerol synthase 1	Homo sapiens	86-89
31686356-0	2020	Backbone and side chain 1H, 15N and 13C chemical shift assignments of the molten globule state of L94G mutant of horse cytochrome-c.	Hydrogen	24-26	cytochrome c, somatic	Equus caballus	119-131
28272630-1	2017	The photocatalytic production of molecular hydrogen (H2) on ternary composites of Pt, CdS, and sodium trititanate nanotubes (NaxH2-xTi3O7, TNTs) is examined in an aqueous 2-propanol (IPA) solution (typically 5 vol%) at a circum-neutral pH under visible light (lambda &gt; 420 nm).	Hydrogen	53-55	troponin T1, slow skeletal type	Homo sapiens	139-143
34186436-11	2021	Differences were observed in hydrogen bonding and hydrophobic interactions between the catalytic and highly conserved DFG motif in the EphA7 mutants, which may influence the catalytic activity of kinase domain.	Hydrogen	29-37	EPH receptor A7	Homo sapiens	135-140
34384784-6	2021	Molecular simulations reveal MIF-2 to contain a comparable hydrogen bond network to that of MIF, which was previously hypothesized to influence catalytic activity by modulating the strength of allosteric coupling.	Hydrogen	59-67	macrophage migration inhibitory factor	Homo sapiens	92-95
28346764-3	2017	Here, we investigated the interactions of three different biochemical probes (Fab s) generated to detect conformational changes in a therapeutic IgG1 antibody (mAbX) by local hydrogen-deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	175-183	FA complementation group B	Homo sapiens	78-81
28447800-2	2017	These complexes have formal Co(-I) oxidation states, representing the only coordination complexes in which dihydrogen is bound to a subvalent transition metal center.	Hydrogen	107-117	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	28-33
28447800-3	2017	Single-crystal X-ray diffraction and NMR studies support the assignment of these complexes as nonclassical dihydrogen adducts of Co(-I).	Hydrogen	107-117	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	129-134
32278260-4	2020	Also, the very low cost of natural gas (the major current hydrogen source) imposes severe economic challenges.	Hydrogen	58-66	gastrin	Homo sapiens	35-38
32058932-0	2020	Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.	Hydrogen	10-18	mechanistic target of rapamycin kinase	Mus musculus	119-123
32058932-13	2020	In both animal and cell research, hydrogen reduced TNF-alpha, IL-6 and HMGB1 levels and M1 polarization, but increased IL-10 and TGF-beta levels and M2 polarization.	Hydrogen	34-42	transforming growth factor alpha	Mus musculus	129-137
32058932-14	2020	Hydrogen treatment decreased the ratio of p-mTOR/mTOR and the expression of p62 and increased the ratio of p-AMPK/AMPK, LC3II/LC3I and the expression of TREM-2 and Beclin-1 in LPS-treated BV-2 cells.	Hydrogen	0-8	mechanistic target of rapamycin kinase	Mus musculus	44-48
32058932-14	2020	Hydrogen treatment decreased the ratio of p-mTOR/mTOR and the expression of p62 and increased the ratio of p-AMPK/AMPK, LC3II/LC3I and the expression of TREM-2 and Beclin-1 in LPS-treated BV-2 cells.	Hydrogen	0-8	mechanistic target of rapamycin kinase	Mus musculus	49-53
32058932-14	2020	Hydrogen treatment decreased the ratio of p-mTOR/mTOR and the expression of p62 and increased the ratio of p-AMPK/AMPK, LC3II/LC3I and the expression of TREM-2 and Beclin-1 in LPS-treated BV-2 cells.	Hydrogen	0-8	beclin 1, autophagy related	Mus musculus	164-172
32058932-15	2020	MHY1485, an mTOR activator, abolished the protective effects of hydrogen in vitro.	Hydrogen	64-72	mechanistic target of rapamycin kinase	Mus musculus	12-16
34410145-6	2021	Our findings challenge the conventional wisdom that radical site regeneration, being central to PAH growth, requires sequential hydrogen elimination and/or abstraction.	Hydrogen	128-136	phenylalanine hydroxylase	Homo sapiens	96-99
32058932-16	2020	Taken together, these results demonstrated that hydrogen attenuated sepsis-induced neuroinflammation by modulating microglia polarization, which was mediated by the mTOR-autophagy signaling pathway.	Hydrogen	48-56	mechanistic target of rapamycin kinase	Mus musculus	165-169
32489564-5	2020	Results: Our results showed that hydrogen up-regulated H2S levels via promoting the expression of CBS in the hippocampus, and its treatment alleviated oxidative stress via activating the expression of Nrf2 and HO-1, and then cell apoptosis reduced, furthermore, brain function improved by down-regulating the levels of S100-betaand NSE.	Hydrogen	33-41	enolase 2	Rattus norvegicus	332-335
28467047-6	2017	All of the derivatives bearing a halogen substituent in the B10 position exhibit a remarkable antipodal 13C and 1H NMR shielding at the CH1 vertex, increasing in the order H &lt; I &lt; Br &lt; Cl &lt; F. The structures of 1,2-C2B8H8-7,10-X2 derivatives (where X = Cl, I, 4b,d) were established by X-ray diffraction analyses.	Hydrogen	112-114	SUN domain containing ossification factor	Homo sapiens	136-139
28422217-7	2017	We use molecular dynamics simulations to determine the conformational space, loop dynamics and hydrogen bond distributions at the active site of DHFR for the WT and the L28R mutant.	Hydrogen	95-103	Dihydrofolate reductase	Escherichia coli	145-149
34704413-11	2021	The 3D structural model showed that p.Arg53His mutation reduced the hydrogen bond from 2 to 1 between the 53rd and 49th amino acids of PAH.	Hydrogen	68-76	phenylalanine hydroxylase	Homo sapiens	135-138
28191842-9	2017	Since this state is entropically unfavorable, the 3"-CE sLeX mimic molecule might be pushed toward the binding pocket of E-selectin by a hydrophobic effect, leading to a higher probability of hydrogen-bond formation than native sLeX and the 3"-CM sLeX mimic.	Hydrogen	192-200	selectin E	Homo sapiens	121-131
32134645-6	2020	4 reacts with H2 at -40  C to form [Ru(PPh3)3(H)3(ZnMe)], 8-Zn, and contrasts the analogous reactions of 1, 2, and 3 that all require heating to 60  C. This marked difference in reactivity reflects the ability of Zn to promote a rate-limiting C-H reductive elimination step, and calculations attribute this to a significant stabilization of 5 via Ru   Zn donation.	Hydrogen	14-16	protein phosphatase 4 catalytic subunit	Homo sapiens	39-43
32478642-3	2020	This can be overcome by using oxyhydrogen, which is a mixture of hydrogen and oxygen gas.	Hydrogen	33-41	gastrin	Homo sapiens	85-88
34502041-8	2021	Further, we found that the Alpha variant had increased hydrogen interaction with Lys353 of hACE2 and more binding affinity in comparison to WT.	Hydrogen	55-63	angiotensin converting enzyme 2	Homo sapiens	91-96
32258867-4	2020	Results show that mixing 75 wt % of DMF with 25 wt % GBL enhanced the membrane gas permeability toward hydrogen, methane, helium, carbon dioxide, and nitrogen.	Hydrogen	103-111	gastrin	Homo sapiens	79-82
32067448-3	2020	The In hydrides were formed by treatment of an In-exchanged CHA zeolite (In-CHA) with H2 at high temperatures (>773 K).	Hydrogen	86-88	transcription factor like 5	Homo sapiens	60-63
28121391-0	2017	Heterostructured WS2 -MoS2 Ultrathin Nanosheets Integrated on CdS Nanorods to Promote Charge Separation and Migration and Improve Solar-Driven Photocatalytic Hydrogen Evolution.	Hydrogen	158-166	CDP-diacylglycerol synthase 1	Homo sapiens	62-65
28121391-4	2017	When assessed as a photocatalyst for water splitting, the CdS/WS2 -MoS2 nanostructures exhibited remarkable photocatalytic hydrogen-evolution performance and impressive durability.	Hydrogen	123-131	CDP-diacylglycerol synthase 1	Homo sapiens	58-61
28121391-5	2017	An excellent hydrogen evolution rate of 209.79 mmol g-1  h-1 was achieved under simulated sunlight irradiation, which is higher than the values for CdS/MoS2 (123.31 mmol g-1  h-1 ) and CdS/WS2 nanostructures (169.82 mmol g-1  h-1 ) and the expensive CdS/Pt benchmark catalyst (34.98 mmol g-1  h-1 ).	Hydrogen	13-21	CDP-diacylglycerol synthase 1	Homo sapiens	185-188
28121391-5	2017	An excellent hydrogen evolution rate of 209.79 mmol g-1  h-1 was achieved under simulated sunlight irradiation, which is higher than the values for CdS/MoS2 (123.31 mmol g-1  h-1 ) and CdS/WS2 nanostructures (169.82 mmol g-1  h-1 ) and the expensive CdS/Pt benchmark catalyst (34.98 mmol g-1  h-1 ).	Hydrogen	13-21	CDP-diacylglycerol synthase 1	Homo sapiens	185-188
28121391-7	2017	The observed high rate of hydrogen evolution and remarkable stability may be a result of the ultrafast separation of photogenerated charge carriers and transport between the CdS nanorods and the WS2 -MoS2 nanosheets, which thus increases the number of electrons involved in hydrogen production.	Hydrogen	26-34	CDP-diacylglycerol synthase 1	Homo sapiens	174-177
28121391-7	2017	The observed high rate of hydrogen evolution and remarkable stability may be a result of the ultrafast separation of photogenerated charge carriers and transport between the CdS nanorods and the WS2 -MoS2 nanosheets, which thus increases the number of electrons involved in hydrogen production.	Hydrogen	274-282	CDP-diacylglycerol synthase 1	Homo sapiens	174-177
32067448-3	2020	The In hydrides were formed by treatment of an In-exchanged CHA zeolite (In-CHA) with H2 at high temperatures (>773 K).	Hydrogen	86-88	transcription factor like 5	Homo sapiens	76-79
34149882-7	2021	Hydrogen gas post-conditioning significantly alleviated brain edema and improved neurologic function, reduced ROS production and neuronal pyroptosis, suppressed the expression of IL-1beta and IL-18 whilst upregulating ERK1/2 phosphorylation, but downregulated p38 MAPK activation 24 h post-SAH.	Hydrogen	0-8	mitogen activated protein kinase 3	Rattus norvegicus	218-224
32065177-5	2020	UV-vis and FT-IR spectroscopy and XRD studies reveal that the stable luminescence of the H6L/Tb gel depends on heat-set-induced strong hydrogen bonding, pi-pi stacking, and metal-ligand interactions.	Hydrogen	135-143	H6 family homeobox 2	Homo sapiens	89-92
31943432-2	2020	The macrocyclic ligand Me4TACD (1,4,7,10-tetramethyl-1,4,7,10-tetraaminocyclododecane, L) stabilizes the full range of triphenylsilyl complexes [(L)MSiPh3]n (M = Li-Cs) which react with H2 or PhSiH3 to form molecular [(L)MSiH3]n that can be isolated in soluble form and fully characterized.	Hydrogen	186-188	protocadherin beta 17 pseudogene	Homo sapiens	23-26
28267563-5	2017	The treated mice were administered Angptl4 1h after the ischemic event upon reperfusion.	Hydrogen	43-45	angiopoietin-like 4	Mus musculus	35-42
28279801-8	2017	Structural modeling of RT suggests that T369V/I substitutions disrupt powerful hydrogen bonds formed by T369 and V365 in p51 and p66.	Hydrogen	79-87	tumor protein p63	Homo sapiens	121-124
28279801-8	2017	Structural modeling of RT suggests that T369V/I substitutions disrupt powerful hydrogen bonds formed by T369 and V365 in p51 and p66.	Hydrogen	79-87	DNA polymerase delta 3, accessory subunit	Homo sapiens	129-132
34149882-9	2021	Therefore, these observations suggest that post-conditioning with hydrogen gas ameliorated SAH-induced neuronal pyroptosis at least in part through the mitoKATP/ERK1/2/p38 MAPK signaling pathway.	Hydrogen	66-74	mitogen activated protein kinase 3	Rattus norvegicus	161-167
34097954-2	2021	Based on the regulation and control of hydrogen bonding network, CS and CNFs can extend the processing window and improve the thermoplasticity of PVA composites.	Hydrogen	39-47	citrate synthase	Homo sapiens	65-67
28362282-2	2017	MP2/aug-cc-pVDZ calculations were performed on the pi-hole interactions in the HCN...Z3X3 complexes and the mutual influence between pi-hole interactions and the hydrogen bond in the HCN...HCN...Z3X3 and HCN...Z3X3...HCN complexes studied.	Hydrogen	162-170	tryptase pseudogene 1	Homo sapiens	0-3
28091961-3	2017	Here we report the 1H, 13C and 15N backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2.	Hydrogen	19-21	ubiquitin specific peptidase 1	Homo sapiens	92-95
34097954-3	2021	Fourier transform infrared spectroscopy and Raman spectra analysis indicate that the intra- and inter-molecular hydrogen bonds of PVA are broken, accompanied by the formation of new hydrogen bonds among PVA, CS and CNFs during the melt-processing treatment.	Hydrogen	112-120	citrate synthase	Homo sapiens	208-210
28109809-8	2017	Molecular docking simulation revealed that 4 interacts with Asn181 residue of MAO-A or Asn116 residue of MAO-B by formation of hydrogen bond.	Hydrogen	127-135	monoamine oxidase A	Homo sapiens	78-83
31972390-6	2020	The docking studies showed that compound 5b could be inserted into the active pocket of alpha-glucosidase and form hydrogen bonds with LYS293 to enhance the binding affinity.	Hydrogen	115-123	sucrase-isomaltase	Homo sapiens	88-105
34097954-3	2021	Fourier transform infrared spectroscopy and Raman spectra analysis indicate that the intra- and inter-molecular hydrogen bonds of PVA are broken, accompanied by the formation of new hydrogen bonds among PVA, CS and CNFs during the melt-processing treatment.	Hydrogen	182-190	citrate synthase	Homo sapiens	208-210
28265627-7	2017	In addition, cis-1,2-disulfide-bridged complex 3 can slowly convert into trans-1,2-disulfide-bridged complex 4 and the complex [Cp*Fe(mu-eta2:eta2-S2)(cis-mu-eta1:eta1-S2)FeCp*] (5) by self-assembly reaction at ambient temperature, which is evidenced by time-dependent 1H NMR spectroscopy.	Hydrogen	269-271	secreted phosphoprotein 1	Homo sapiens	158-162
31982651-6	2020	High binding affinity toward MOR of compound 2a was associated with water bridge, salt bridge, hydrogen bond and hydrophobic interaction with MOR.	Hydrogen	95-103	opioid receptor mu 1	Homo sapiens	29-32
28265627-7	2017	In addition, cis-1,2-disulfide-bridged complex 3 can slowly convert into trans-1,2-disulfide-bridged complex 4 and the complex [Cp*Fe(mu-eta2:eta2-S2)(cis-mu-eta1:eta1-S2)FeCp*] (5) by self-assembly reaction at ambient temperature, which is evidenced by time-dependent 1H NMR spectroscopy.	Hydrogen	269-271	secreted phosphoprotein 1	Homo sapiens	163-167
34337607-3	2021	Here we show by a combined computational design, experimental, and molecular dynamics (MD) study that local mutations have not only a local but also a global effect on the solvent: In the specific case of the matrix metalloprotease MMP14, we found that the nature of local mutations, coupled with surface morphology, have the ability to influence large patches of the water hydrogen-bonding network at the protein surface, which is correlated with stability.	Hydrogen	374-382	matrix metallopeptidase 14	Homo sapiens	232-237
31930571-0	2020	Molecular hydrogen regulates PTEN-AKT-mTOR signaling via ROS to alleviate peritoneal dialysis-related peritoneal fibrosis.	Hydrogen	10-18	phosphatase and tensin homolog	Homo sapiens	29-33
31930571-8	2020	Furthermore, it has been found that molecular hydrogen alleviate fibrosis by eliminating intracellular ROS and inhibiting the activation of the PTEN/AKT/mTOR pathway.	Hydrogen	46-54	phosphatase and tensin homolog	Homo sapiens	144-148
34213879-4	2021	Here, we demonstrate that borophene films can be synthesized onto a mica substrate by van der Waals epitaxy, where hydrogen and NaBH4 are respectively used as the carrier gas and the boron source.	Hydrogen	115-123	MHC class I polypeptide-related sequence A	Homo sapiens	68-72
31930571-9	2020	The present data proposes that molecular hydrogen exerts the capacity of anti-peritoneal fibrosis through the ROS/PTEN/AKT/mTOR pathway.	Hydrogen	41-49	phosphatase and tensin homolog	Homo sapiens	114-118
31744771-5	2020	We further recognised that the C NMR chemical shifts of the nominal phenyl carbons (C(3)/C(7) and C(4)/C(6)) encode information for intramolecular hydrogen bonding network formed by GA conformers.	Hydrogen	147-155	complement C4A (Rodgers blood group)	Homo sapiens	98-102
28323896-9	2017	Structural modeling indicated that the increased efficiency of dZ phosphorylation by the DmdNK-Q81E mutant might be related to the three additional hydrogen bonds formed between E81 and the dZ base.	Hydrogen	148-156	deoxyribonucleoside kinase	Drosophila melanogaster	89-94
31924036-4	2020	The FT-IR of NBent-NTiO2-Chit confirmed the presence of OH, N-H, Si-O-Al and Si-O-Si functional groups.	Hydrogen	60-63	chitinase 1	Homo sapiens	25-29
34266277-8	2021	It is found that in water and methanol, the most abundant conformers of ML are structurally modified relative to the gas phase, where the major form is ML1, in which the syn conformation of the -OH moiety is stabilized by a OH O=C intramolecular hydrogen bond (HB).	Hydrogen	246-254	interleukin 17F	Homo sapiens	152-155
31703229-0	2020	Detection of H-FABPA by novel SERS combined with magnetic reaction.	Hydrogen	13-20	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	30-34
31960837-1	2020	Herein, an environmentally friendly CoP/Zn2In2S5 catalyst is reported as a visible-light photocatalyst for the selective activation of the alpha-C-H bond of methanol to generate ethylene glycol with a selectivity of as high as 90%.	Hydrogen	139-148	caspase recruitment domain family member 16	Homo sapiens	36-39
28202527-3	2017	High glutaminase (GLS) activity in TNBC tumors resulted in low cellular glutamine pool size assayed via high-resolution 1H magnetic resonance spectroscopy (MRS).	Hydrogen	120-122	glutaminase	Homo sapiens	5-16
34243605-8	2021	Docking results showed that compound 3b could bind well with CDK2 by forming hydrogen bonds with amino acid residues (LYS89 and HIS84).	Hydrogen	77-85	cyclin dependent kinase 2	Homo sapiens	61-65
28282025-5	2017	All NESs also participate in main chain hydrogen bonding with human CRM1 Lys568 side chain, which acts as a specificity filter that prevents binding of non-NES peptides.	Hydrogen	40-48	exportin 1	Homo sapiens	68-72
28339658-0	2017	Acute cell volume regulation by Janus kinase 2-mediated sodium/hydrogen exchange activation develops at the late one-cell stage in mouse preimplantation embryos.	Hydrogen	63-71	Janus kinase 2	Mus musculus	32-46
31823472-2	2020	Whereas its anomeric carbon (C-1) is oxidized to a carboxy group, the hydroxy group on the C-2 carbon is replaced by hydrogen.	Hydrogen	117-125	complement C2	Homo sapiens	91-94
28013136-5	2017	The hydrogen yield of 301mLH2/gglucose with the mutant was higher by 81.8% than that of 166mL/gglucose with the wild strain.	Hydrogen	4-12	LIM homeobox protein 2	Mus musculus	25-29
34168168-4	2021	Spike protein exhibited the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2.	Hydrogen	118-126	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	0-5
28108962-0	2017	Determination of Equine Cytochrome c Backbone Amide Hydrogen/Deuterium Exchange Rates by Mass Spectrometry Using a Wider Time Window and Isotope Envelope.	Hydrogen	52-60	cytochrome c, somatic	Equus caballus	24-36
28108962-8	2017	Application of this strategy to cytochrome c yielded 97 out of 100 amide hydrogen exchange rates.	Hydrogen	73-81	cytochrome c, somatic	Equus caballus	32-44
34168168-4	2021	Spike protein exhibited the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2.	Hydrogen	118-126	angiotensin converting enzyme 2	Homo sapiens	56-60
34168168-4	2021	Spike protein exhibited the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2.	Hydrogen	118-126	angiotensin converting enzyme 2	Homo sapiens	138-143
34071853-5	2021	The results display that meta-connected M-2,7-CPPI has less ordered chain structure and weaker hydrogen bonding than para-connected 2,7-CPPI, which leads to loose chain stacking and thereby increased free volumes of M-2,7-CPPI.	Hydrogen	95-103	cathepsin C	Homo sapiens	46-50
28130641-6	2017	Theoretical analysis based on MP2 and DFT shows that the interaction between the serine and nucleobases is mainly determined by hydrogen bonding.	Hydrogen	128-136	tryptase pseudogene 1	Homo sapiens	30-33
28098910-7	2017	In conclusion, H2-rich saline may significantly improve NAFLD, possibly by reducing oxidative stress and activating hepatic PPARalpha and PPARgamma expression.	Hydrogen	15-17	peroxisome proliferator activated receptor alpha	Rattus norvegicus	124-133
28193005-3	2017	Here, we report the identification of an energetic epitope by determining the interfacial hot-spot that dominates the binding affinity for an anti-interleukin-23 (anti-IL-23) antibody by using the complementary approaches of hydrogen/deuterium exchange mass spectrometry (HDX-MS), fast photochemical oxidation of proteins (FPOP), alanine shave mutagenesis, and binding analytics.	Hydrogen	225-233	interleukin 23 subunit alpha	Homo sapiens	168-173
34071853-5	2021	The results display that meta-connected M-2,7-CPPI has less ordered chain structure and weaker hydrogen bonding than para-connected 2,7-CPPI, which leads to loose chain stacking and thereby increased free volumes of M-2,7-CPPI.	Hydrogen	95-103	cathepsin C	Homo sapiens	222-226
34066547-0	2021	Catalytic Methane Decomposition to Carbon Nanostructures and COx-Free Hydrogen: A Mini-Review.	Hydrogen	70-78	cytochrome c oxidase subunit 8A	Homo sapiens	61-64
28194036-4	2017	A procedure to obtain a passivated hydrogen-functionalized tip is defined and evolution of atomic force microscopy images at different tip elevations are shown.	Hydrogen	35-43	TOR signaling pathway regulator	Homo sapiens	59-62
28194036-4	2017	A procedure to obtain a passivated hydrogen-functionalized tip is defined and evolution of atomic force microscopy images at different tip elevations are shown.	Hydrogen	35-43	TOR signaling pathway regulator	Homo sapiens	135-138
34066547-1	2021	Catalytic methane decomposition (CMD) is a highly promising approach for the rational production of relatively COx-free hydrogen and carbon nanostructures, which are both important in multidisciplinary catalytic applications, electronics, fuel cells, etc.	Hydrogen	120-128	cytochrome c oxidase subunit 8A	Homo sapiens	111-114
34230907-6	2021	Hydrogen-bond analyses reveal key residues of RBD for strong hydrogen-bond interactions between RBDs and antibodies, which help in the rational design of vaccine and drug molecules targeting the S protein of SARS-CoV-2.	Hydrogen	0-8	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	195-196
27021432-2	2017	The method combines a sample preparation and enrichment step based on cloud point extraction with a new detection motif that relies on the optical incoherent light scattering of a nano-hybrid assembly that is formed by hydrogen bond interactions between gold nanoparticles and dithiotreitol-functionalized CdS quantum dots.	Hydrogen	219-227	CDP-diacylglycerol synthase 1	Homo sapiens	306-309
27730365-7	2017	The maximum values for the specific PHB and hydrogen production rates were 16.4 mg-PHB/g-TSS/day and 391 mL-H2/g-TSS/day, respectively.	Hydrogen	44-52	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	105-110
34230907-6	2021	Hydrogen-bond analyses reveal key residues of RBD for strong hydrogen-bond interactions between RBDs and antibodies, which help in the rational design of vaccine and drug molecules targeting the S protein of SARS-CoV-2.	Hydrogen	61-69	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	195-196
34062881-4	2021	Based on molecular docking results, we suppose that adamantane derivatives of resin acids bind to the TDP1 covalent intermediate, forming a hydrogen bond with Ser463 and hydrophobic contacts with the Phe259 and Trp590 residues and the oligonucleotide fragment of the substrate.	Hydrogen	140-148	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	102-106
28001341-0	2017	Graphitic C3 N4 Decorated with CoP Co-catalyst: Enhanced and Stable Photocatalytic H2 Evolution Activity from Water under Visible-light Irradiation.	Hydrogen	83-85	caspase recruitment domain family member 16	Homo sapiens	31-34
34234394-7	2021	Group-A S protein"s RBD bound imperceptibly to the two binding clefts of the hACE2 protein, on the other hand, Group-B S protein"s RBD perfectly interacted inside the binding clefts of hACE2, with higher number of hydrogen and hydrophobic interactions.	Hydrogen	214-222	angiotensin converting enzyme 2	Homo sapiens	185-190
34603638-7	2021	Moreover, the binding free energy and hydrogen bond distribution analysis of RBD-ACE2 binding interface provided the binding motifs that may be critical to allosteric signal transmission and RBD binding.	Hydrogen	38-46	angiotensin converting enzyme 2	Homo sapiens	81-85
35152498-5	2022	When binding with GAP, both mutations weakened the hydrogen bond interactions between Cdc42-GTP and GAP"s finger loop, and disturbed the catalytically competent organizations of GAP"s catalytic R305/R306 and Cdc42"s Q61, thereby impairing the GAP-mediated GTP hydrolysis.	Hydrogen	51-59	cell division cycle 42	Homo sapiens	86-91
35219199-0	2022	Boron-induced activation of Ru nanoparticles anchored on carbon nanotubes for the enhanced pH-independent hydrogen evolution reaction.	Hydrogen	106-114	phenylalanine hydroxylase	Homo sapiens	91-93
35583118-4	2022	As the proteins approached, the glycan of ACE2 first established a hydrogen bond with the RBD.	Hydrogen	67-75	angiotensin converting enzyme 2	Homo sapiens	42-46
35583118-7	2022	The spatial distribution function of the solvent revealed the presence of hydrogen bonds bridged by water molecules on the RBD-ACE2 interface.	Hydrogen	74-82	angiotensin converting enzyme 2	Homo sapiens	127-131
35635004-2	2022	Therefore, focusing on the specific Cys552 of FGFR4 subtype, we designed and synthesized a novel family of 1,6-naphthyridin-2(1H)-one derivatives as potent and highly selective FGFR4 inhibitors.	Hydrogen	126-128	fibroblast growth factor receptor 4	Homo sapiens	46-51
35635004-2	2022	Therefore, focusing on the specific Cys552 of FGFR4 subtype, we designed and synthesized a novel family of 1,6-naphthyridin-2(1H)-one derivatives as potent and highly selective FGFR4 inhibitors.	Hydrogen	126-128	fibroblast growth factor receptor 4	Homo sapiens	177-182
35158192-4	2022	Benefiting from these advantages, the optimized hierarchical ZnS@SnS2 heterostructured cages exhibit significant gas-phase CO2 photoreduction activity with a CO generation rate of 95.38 mumol g-1h-1 and 72.4% CO selectivity, which are greatly improved in comparison with those of pure ZnS cages and nanosheet-assembled SnS2 particles.	Hydrogen	194-196	sodium voltage-gated channel alpha subunit 11	Homo sapiens	65-69
35158192-6	2022	The optimized ZnS@SnS2/CdS hybrid exhibits a CO generation rate of 155.57 mumol g-1h-1 and an excellent selectivity of 80.4%.	Hydrogen	82-84	sodium voltage-gated channel alpha subunit 11	Homo sapiens	18-22
34998156-5	2022	Hydrogen bonding, electrostatic interactions, and hydrophobic interactions were the main binding forces between T1R1/T1R3 and umami peptides.	Hydrogen	0-8	taste 1 receptor member 1	Homo sapiens	112-116
34998156-5	2022	Hydrogen bonding, electrostatic interactions, and hydrophobic interactions were the main binding forces between T1R1/T1R3 and umami peptides.	Hydrogen	0-8	taste 1 receptor member 3	Homo sapiens	117-121
35625526-4	2022	The docking results indicated that Omicron BA.2 has exceptionally strong interactions with hACE2 in comparison to Omicron BA.1, Delta, and wild-type, as indicated by various parameters such as salt bridge, hydrogen bond, and non-bonded interactions.	Hydrogen	206-214	angiotensin converting enzyme 2	Homo sapiens	91-96
31834838-6	2020	Hydrogen/deuterium exchange coupled to mass spectrometry narrowed down the region of interaction to KCNQ1 residues 352-374 and KCNE1 residues 70-81, and provided evidence of secondary structure within these segments.	Hydrogen	0-8	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	100-105
35293679-5	2022	MTF-1 has been explored as efficient catalyst for electrochemical and photoelectrochemical hydrogen evolution reaction (HER) via water splitting reactions.	Hydrogen	91-99	metal regulatory transcription factor 1	Homo sapiens	0-5
31751818-8	2020	We conducted molecular docking study and found that the compound and alpha-glucosidase were mainly non-covalently interacting with hydrogen bonds and van der Waals forces.	Hydrogen	131-139	sucrase-isomaltase	Homo sapiens	69-86
35438962-4	2022	Two key factors affecting the interaction between CH and CYP46A1 are determined: one is a hydrophobic cavity formed by seven hydrophobic residues (F80, Y109, L112, I222, W368, F371, and T475), which provides nonpolar interactions to stabilize CH, and the other is a hydrogen bond formed by H81 and CH, which ensures the binding direction of CH.	Hydrogen	266-274	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	57-64
31852836-7	2020	Hydrogen/deuterium exchange data complements this analysis revealing that the C-lobe in full-length MASTL forms a stable structure, whereas the N-lobe is dynamic and the NCMR and C-tail contain few localized regions with higher-order structure.	Hydrogen	0-8	microtubule associated serine/threonine kinase like	Homo sapiens	100-105
31860021-5	2020	Two phenylalanine stacked with bases of RNA were crucial for RNA binding, and a series of hydrogen bonds between the base atoms of RNA and main-chain or side-chain atoms of RBM38 determine the sequence-specific recognition.	Hydrogen	90-98	RNA binding motif protein 38	Homo sapiens	173-178
35367419-7	2022	According to Protein Data Bank database GA could form hydrogen bonds between LYS65, GLU157, ASN17, ARG109, ARG106 of MMP9 protein, a target of GA.	Hydrogen	54-62	matrix metallopeptidase 9	Mus musculus	117-121
31790250-0	2020	Spontaneous Formation of >90% Optically Transmissive, Electrochemically Active CoP Films for Photoelectrochemical Hydrogen Evolution.	Hydrogen	114-122	caspase recruitment domain family member 16	Homo sapiens	79-82
31830177-5	2020	Stability tests reveal that both HP1 and HP2 show hydrogen evolution in the dark, indicating about 0.6% partial decomposition of the hybrid material.	Hydrogen	50-58	defensin alpha 1	Homo sapiens	33-36
35403658-2	2022	In this hydrogel, the rigid chain of chitosan (CS) and the soft chain of copolymer P(AAm-co-AA) with acrylic acid (AA) and acrylamide (AAm) act as the backbone, among which large amounts of hydrogen bonds are formed by the amino, hydroxyl, and carboxyl groups on the two polymers.	Hydrogen	190-198	citrate synthase	Homo sapiens	47-49
31830177-6	2020	This hydrogen evolution increases by a factor of 3 when HP1 and HP2 are exposed to visible light.	Hydrogen	5-13	defensin alpha 1	Homo sapiens	56-59
31735085-7	2020	Vildagliptin directly binds to TRPV4 by forming a hydrogen bond, which is critical to vildagliptin-evoked endothelial calcium intake.	Hydrogen	50-58	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	31-36
35629830-5	2022	At present, existing pH-sensitive materials are mainly based on polyaniline (PANI), hydrogen ionophores (HIs) and metal oxides (MOx).	Hydrogen	84-92	phenylalanine hydroxylase	Homo sapiens	21-23
31430392-5	2020	A method for qualitative and quantitative analysis of 2,4-DNP in blood and urine specimens using GC-MS with hydrogen as carrier gas is described.	Hydrogen	108-116	gastrin	Homo sapiens	128-131
27797162-0	2017	Fe-Doped CoP Nanoarray: A Monolithic Multifunctional Catalyst for Highly Efficient Hydrogen Generation.	Hydrogen	83-91	caspase recruitment domain family member 16	Homo sapiens	9-12
35131618-7	2022	The intermolecular hydrogen bond of the surfactants opens the intramolecular hydrogen bond in the weaker beta-ring of bis-HPTA.	Hydrogen	19-27	hepatocyte growth factor	Homo sapiens	122-126
27797162-1	2017	An Fe-doped CoP nanoarray behaves as a robust 3D monolithic multifunctional catalyst for electrolytic and hydrolytic hydrogen evolution with high activity.	Hydrogen	117-125	caspase recruitment domain family member 16	Homo sapiens	12-15
28215576-0	2017	Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model.	Hydrogen	71-79	interleukin-4	Cavia porcellus	11-15
28215576-2	2017	This study explored the possible roles of H2 on the pathogenesis of AR and observed the influences of H2 on cytokines IL-4 and IL-13.	Hydrogen	102-104	interleukin-4	Cavia porcellus	118-122
31421373-5	2020	RESULTS AND CONCLUSIONS: Mitochondria-targeted OGG1 attenuated indices of lung endothelial dysfunction incurred after a 1h post-mortem period.	Hydrogen	120-122	8-oxoguanine DNA glycosylase	Rattus norvegicus	47-51
35131618-7	2022	The intermolecular hydrogen bond of the surfactants opens the intramolecular hydrogen bond in the weaker beta-ring of bis-HPTA.	Hydrogen	77-85	hepatocyte growth factor	Homo sapiens	122-126
31775157-7	2020	SPT16 binds nucleosomal DNA and tethers H2A-H2B through its C-terminal domain by acting as a placeholder for DNA.	Hydrogen	40-47	SPT16 homolog, facilitates chromatin remodeling subunit	Homo sapiens	0-5
35487772-2	2022	The core-shell structured chitosan-polyethylene oxide@gelatin (CS-PEO@GEL) nanofibers which could form the intramolecular hydrogen bond and achieve an Arg-Gly-Asp (RGD) polymer were first prepared by coaxial electrospinning to mimic the extracellular matrix.	Hydrogen	122-130	citrate synthase	Homo sapiens	63-65
33731981-4	2020	1H NMR titrations show that P1 and P2 are poor hosts toward hydrophobic (di)cations 6 - 11 (P1: Ka = 375-1400 M-1; P2: Ka = 1950-19800 M-1) compared to Tet1 and Tet2 (Tet1: Ka = 3.09 x 106 to 4.69 x 108 M-1; Tet2: Ka = 4.59 x 108 to 1.30 x 1010 M-1).	Hydrogen	0-2	tet methylcytosine dioxygenase 1	Homo sapiens	152-156
33731981-4	2020	1H NMR titrations show that P1 and P2 are poor hosts toward hydrophobic (di)cations 6 - 11 (P1: Ka = 375-1400 M-1; P2: Ka = 1950-19800 M-1) compared to Tet1 and Tet2 (Tet1: Ka = 3.09 x 106 to 4.69 x 108 M-1; Tet2: Ka = 4.59 x 108 to 1.30 x 1010 M-1).	Hydrogen	0-2	tet methylcytosine dioxygenase 1	Homo sapiens	167-171
31669099-6	2020	Next, HepG2 cells were used to examine the action of PPIs and H2 blockers on hepcidin.	Hydrogen	62-64	hepcidin antimicrobial peptide	Homo sapiens	77-85
27826060-7	2017	Analysis of brain gene expression in individuals 1h following social ascent indicates elevated gonadotropin-releasing hormone (GnRH) mRNA levels in the medial preoptic area (mPOA) of the hypothalamus compared to individuals that do not experience a social opportunity.	Hydrogen	49-51	gonadotropin releasing hormone 1	Mus musculus	95-125
27826060-7	2017	Analysis of brain gene expression in individuals 1h following social ascent indicates elevated gonadotropin-releasing hormone (GnRH) mRNA levels in the medial preoptic area (mPOA) of the hypothalamus compared to individuals that do not experience a social opportunity.	Hydrogen	49-51	gonadotropin releasing hormone 1	Mus musculus	127-131
28050723-6	2017	In analogy to CD4, the identified compounds make hydrogen bonds with Asp-368gp120 and multiple van der Waals contacts with the gp120 residues that bind to Phe-43CD4, resulting in destruction of the critical interactions of gp120 with Phe-43CD4 and Arg-59CD4.	Hydrogen	49-57	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	76-81
28050723-6	2017	In analogy to CD4, the identified compounds make hydrogen bonds with Asp-368gp120 and multiple van der Waals contacts with the gp120 residues that bind to Phe-43CD4, resulting in destruction of the critical interactions of gp120 with Phe-43CD4 and Arg-59CD4.	Hydrogen	49-57	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	127-132
28050723-7	2017	The complexes of the CD4-mimetic candidates with gp120 show relative conformational stability within the molecular dynamics simulations and expose the high percentage occupancies of intermolecular hydrogen bonds, in line with the data on the binding free energy calculations.	Hydrogen	197-205	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	49-54
35635953-0	2022	Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker.	Hydrogen	112-120	CDC like kinase 1	Homo sapiens	59-65
26866650-10	2017	Additionally, hydrogen tended to increase protein expressions of antioxidant glutathione peroxidase 1, as well as anti-apoptotic Bcl-2, in skeletal muscle at age 10 weeks.	Hydrogen	14-22	glutathione peroxidase 1	Mus musculus	77-101
28008853-2	2016	Using Hydrogen-Deuterium Exchange-Mass Spectrometry (HDX-MS) we show that Ric-8A disrupts the secondary structure of the Galpha Ras-like domain that girds the guanine nucleotide-binding site, and destabilizes the interface between the Galphai1 Ras and helical domains, allowing domain separation and nucleotide release.	Hydrogen	6-14	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	121-127
31893886-8	2019	This suggests that the strong intramolecular hydrogen bonding of S D OCH3 in 2-MTP at least in the low S1 internal energy region should play a significant role in localizing the reactive flux onto the conical intersection seam.	Hydrogen	45-53	metallothionein 1B	Homo sapiens	79-82
35404067-6	2022	Affinity and potency at CB1 changed as a function of the heterocyclic core (indazole > indole > 7-azaindole) and the pendant amino acid side chain (tert-butyl > iso-propyl > iso-butyl > benzyl > ethyl > methyl > hydrogen).	Hydrogen	212-220	cannabinoid receptor 1 (brain)	Mus musculus	24-27
31725288-6	2019	Together, 41 is a novel Hsp90-Cdc37 disruptor by binding to Cdc37 (hydrogen bond and/or covalent bond).	Hydrogen	67-75	heat shock protein 90 alpha family class A member 1	Homo sapiens	24-29
27497639-12	2016	The binding of oxymatrine to UQCRB was driven by strong enthalpy forces such as hydrogen bonds and polar interactions as the heat released was about 157kcal/mol and DeltaG was less than zero.	Hydrogen	80-88	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	29-34
35384651-5	2022	Here, we explore by hydrogen-deuterium exchange mass spectrometry the dynamic consequences of a classic substrate and inhibitor, vinblastine and zosuquidar, binding to mouse P-gp (mdr1a) in lipid nanodiscs.	Hydrogen	20-28	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	180-185
27641322-7	2016	Intrathecal delivery of the RGS4 inhibitor CCG63802 was found to reverse tactile hypersensitivity for a 1h period.	Hydrogen	104-106	regulator of G-protein signaling 4	Rattus norvegicus	28-32
31750499-3	2019	I2/PEG was established as an efficient and reusable catalytic system for C-H chalcogenation.	Hydrogen	73-76	progestagen associated endometrial protein	Homo sapiens	3-6
31714564-2	2019	The reactions with boranes BX3 SMe2 (X = H, Cl, Br), BF3 OEt2 and BCl3 yield Lewis adducts [BICAAC BH3] (1), [BICAAC BHCl2] (2), [BICAAC BH2Cl] (3), [BICAAC BF3] (4), [BICAAC BCl3] (5) and [BICAAC BBr3] (6) respectively, whereas more hydridic boranes, 9-borabicyclo[3.3.1]nonane (9-BBN) and catecholborane (HBcat), enable the insertion of the carbene carbon into the B-H bond to form [BICAAC(H)-(9-BBN)] (7) and [BICAAC(H)-Bcat] (8).	Hydrogen	367-370	BCL3 transcription coactivator	Homo sapiens	66-70
35349262-0	2022	Incorporating Oxygen Atoms in a SnS2 Atomic Layer to Simultaneously Stabilize Atomic Hydrogen and Accelerate the Generation of Hydroxyl Radicals for Water Decontamination.	Hydrogen	85-93	sodium voltage-gated channel alpha subunit 11	Homo sapiens	32-36
31754768-3	2019	Comparison between normal and SERS spectra of ATP isomers supports the fact that additional disulfide- or hydrogen-bonding interactions are established in para-ATP solid crystal, but neither of ortho- nor meta-isomers.	Hydrogen	106-114	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	30-34
27884327-1	2016	BACKGROUND: The goals of this study were to validate the role of c-Jun N-terminal kinase (JNK) activation in skin flap apoptosis in a rat model of abdomen skin ischemia and/or reperfusion (IR) and to compare the protective effect of SP600125 and hydrogen-rich saline in skin IR injury.	Hydrogen	246-254	mitogen-activated protein kinase 8	Rattus norvegicus	90-93
35582347-4	2022	The MoS2-NC200 cathode, electrodeposited at -200 muA cm-2, showed the maximum hydrogen production rate of 0.152 +- 0.002 m3 H2 m-2 d-1 at 0.9V of Eap, which is comparable to the previously reported Pt electrodes.	Hydrogen	78-86	glutamyl aminopeptidase	Homo sapiens	146-149
27934241-0	2016	LIF Spectroscopy of p-Fluorophenol   Water Complex: Hydrogen Bond Vibrations, Fermi Resonance, and Vibrational Relaxation in the Excited State.	Hydrogen	52-60	LIF interleukin 6 family cytokine	Homo sapiens	0-3
31464869-6	2019	RESULTS: The levels of TNF-alpha in plasma were gradually increased after 1h of LPS administration and reached the peak at 6 h. The contractile responses of SMA to NE were decreased at 1h of LPS and lowest at 6h.	Hydrogen	74-76	tumor necrosis factor	Oryctolagus cuniculus	23-32
35419901-2	2022	DAP hydrides can act as stoichiometric hydrogen atom transfer agents in radical reactions.	Hydrogen	39-47	death associated protein	Homo sapiens	0-3
31464869-6	2019	RESULTS: The levels of TNF-alpha in plasma were gradually increased after 1h of LPS administration and reached the peak at 6 h. The contractile responses of SMA to NE were decreased at 1h of LPS and lowest at 6h.	Hydrogen	185-187	tumor necrosis factor	Oryctolagus cuniculus	23-32
31464869-8	2019	The further studies found that calcium desensitization participated in the occurrence of TNF-alpha-induced vascular hyporeactivity, the changes were consistent with the changes of vascular reactivity, calcium sensitivities were decreased significantly at 1h, 2h, 4h, and 6h after LPS injection.	Hydrogen	255-257	tumor necrosis factor	Oryctolagus cuniculus	89-98
31618006-3	2019	Here, we interstitially modulate hydrogen atoms into RhPd nanoparticles to boost the alkaline hydrogen evolution reaction (HER).	Hydrogen	33-41	nephrocystin 3	Homo sapiens	53-57
27774529-3	2016	By taking account of both effects, we obtained a symmetric single-well effective PEC for H-TTF, which indicated that the hydrogen was always located at the center of the H-bond.	Hydrogen	121-129	ras homolog family member H	Homo sapiens	91-94
35397701-0	2022	Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.	Hydrogen	101-109	tripartite motif containing 69	Homo sapiens	58-64
31618006-3	2019	Here, we interstitially modulate hydrogen atoms into RhPd nanoparticles to boost the alkaline hydrogen evolution reaction (HER).	Hydrogen	94-102	nephrocystin 3	Homo sapiens	53-57
31618006-6	2019	These modifications give RhPd-H nanoparticles a desirable hydrogen adsorption free energy, thus accelerating the hydrogen gas production.	Hydrogen	58-66	nephrocystin 3	Homo sapiens	25-29
31618006-6	2019	These modifications give RhPd-H nanoparticles a desirable hydrogen adsorption free energy, thus accelerating the hydrogen gas production.	Hydrogen	113-121	nephrocystin 3	Homo sapiens	25-29
35397701-6	2022	Using hydrogen-deuterium exchange mass spectrometry (HDXMS), we mapped the interface of the interaction between TRIM69 and NS2B-NS3Deltapro, and propose a rationale for the binding and subsequent ubiquitination process.	Hydrogen	6-14	tripartite motif containing 69	Homo sapiens	112-118
35348140-5	2022	The separated charge carriers have been utilized in visible light driven hydrogen production and the hydrogen generation activity follows the same order as that for the lifetime of the CS state, underlining the role of charge separation efficiency.	Hydrogen	101-109	citrate synthase	Homo sapiens	185-187
31699336-10	2019	Urea being a denaturant interacts more with these regions of alpha-synuclein through hydrogen bond formation and inhibits the beta-sheet formation, whereas trimethyl amine oxide itself does not interact much with the protein and stabilizes the protein by preferentially distributing water molecules on the surface of the protein.	Hydrogen	85-93	synuclein alpha	Homo sapiens	61-76
35190875-2	2022	The results showed that the fluorescence quenching of CcrA induced by CTX and CAZ were all due to the complex formation, which belonged to static quenching and was forced by hydrogen bonds and Van der Waals forces, despite the greater binding ability of CTX with CcrA than CAZ.	Hydrogen	174-182	cfiA	Bacteroides fragilis	54-58
31719553-6	2019	Furthermore, the hydrogen storage capacity of the ScC nanotubes has been explored.	Hydrogen	17-25	serpin family B member 3	Homo sapiens	50-53
31719553-7	2019	The calculated results show that one unit of the (0,3) ScC nanotube can adsorb a maximum of 51 hydrogen molecules, reaching up to a 6.25 wt% hydrogen gravimetric density with an average binding energy of 0.23 eV/H2.	Hydrogen	95-103	serpin family B member 3	Homo sapiens	55-58
31719553-7	2019	The calculated results show that one unit of the (0,3) ScC nanotube can adsorb a maximum of 51 hydrogen molecules, reaching up to a 6.25 wt% hydrogen gravimetric density with an average binding energy of 0.23 eV/H2.	Hydrogen	141-149	serpin family B member 3	Homo sapiens	55-58
31621324-3	2019	As a model application, the open-shell ALMO-MP2-EDA is applied to study the first solvation step of halogenated benzene radical cations, where both halogen- and hydrogen-bonded isomers are possible.	Hydrogen	161-169	tryptase pseudogene 1	Homo sapiens	44-47
35104595-4	2022	TRPV1 activation was assessed by monitoring calcium influx kinetics over 1h in cells pre-treated with the fluorescent indicator Fluo-4.	Hydrogen	73-75	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
32051770-3	2019	Here, we examined dihydrofolate reductase (DHFR), an enzyme that catalyzes hydride from C4" of NADPH to C6 of 7,8-dihydrofolate (H2F).	Hydrogen	129-132	dihydrofolate reductase	Homo sapiens	18-41
31753071-5	2019	In our simulation, both CoI and CoII-H feature a strong interaction with the surrounding solvent via hydrogen bonding, which is expected to foster the following catalytic step.	Hydrogen	101-109	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	24-27
31720452-9	2019	At pH 5.0, the interaction between DPPC and LAH increased the Tm and phase transition cooperativity showing a single lipid phase formed by hydrogen-bonded DPPC: LAH complexes.	Hydrogen	139-147	desmoglein 4	Homo sapiens	44-47
31720452-9	2019	At pH 5.0, the interaction between DPPC and LAH increased the Tm and phase transition cooperativity showing a single lipid phase formed by hydrogen-bonded DPPC: LAH complexes.	Hydrogen	139-147	desmoglein 4	Homo sapiens	161-164
27561732-5	2016	Results show that hydrogen bonding and hydrophobic interactions are the dominant interactions between the ligands and hAR.	Hydrogen	18-26	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	118-121
27561732-6	2016	The critical amino acid residues involved in forming hydrogen bonding between bisphenols and hAR is Asn 705 and Gln 711.	Hydrogen	53-61	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	93-96
27734179-4	2016	By applying a zero frequency spectral density rescaling analysis to the relaxation data collected at magnetic fields from 500 to 900 MHz 1H, differential residue-specific 15N CSA values have been obtained for GB3 which correlate with those derived from solid state and liquid crystalline NMR measurements to a level similar to the correlation among those previously reported studies.	Hydrogen	137-139	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	209-212
27518466-0	2016	Hydrogen-Rich Saline Attenuates Acute Hepatic Injury in Acute Necrotizing Pancreatitis by Inhibiting Inflammation and Apoptosis, Involving JNK and p38 Mitogen-Activated Protein Kinase-dependent Reactive Oxygen Species.	Hydrogen	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	139-142
27518466-9	2016	CONCLUSIONS: Hydrogen-rich saline plays a protective role in ANP-induced AHI through inhibiting inflammation and apoptosis, involving JNK and p38 MAPK-dependent reactive oxygen species.	Hydrogen	13-21	mitogen-activated protein kinase 8	Rattus norvegicus	134-137
27732000-3	2016	cis,cis-1,5-Cyclooctadiene was identified as the most effective sacrificial hydrogen acceptor for the dehydrogenative silylation of vinylarenes, which allows use of a nearly equimolar ratio of alkenes and silanes.	Hydrogen	76-84	suppressor of cytokine signaling 1	Homo sapiens	4-9
35406210-2	2022	The resulting composite film showed good mechanical strength, with a tensile strength reaching 71.84 Mpa due to the high flexibility of CNF and the combination of CS, CNF and BPEI through strong hydrogen bonding interactions.	Hydrogen	195-203	citrate synthase	Homo sapiens	163-165
27668313-3	2016	Here we present electrochemical measurement of Laplace pressures within single H2 bubbles between 7 and 200 nm radius (corresponding, respectively, to between 200 and 7 atm).	Hydrogen	79-81	ATM serine/threonine kinase	Homo sapiens	169-172
27676264-4	2016	Density functional theory calculations further reveal that Fe substitution of Co in CoP leads to more optimal free energy of hydrogen adsorption to the catalyst surface.	Hydrogen	125-133	caspase recruitment domain family member 16	Homo sapiens	84-87
35045269-6	2022	Also, the L753 mutation linked to the Y756 hydrogen bond prevents the S protein from being cleaved.	Hydrogen	43-51	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	70-71
27782425-7	2016	A detailed comparison of the present and previous results on O2-CF4 and O2-CCl4 systems pinpointed striking differences in the behavior of hydrogen and oxygen molecules when they interact with the same partner, mainly due to the selectivity of the charge transfer component.	Hydrogen	139-147	C-C motif chemokine ligand 4	Homo sapiens	75-79
27711686-3	2016	This indicates that (1) the [OMIM] cation exists in CCl4 as a monomer, dissociated from the anion and other cations, and (2) hydrogen bonding between the anion and the cation increases the dipole strength of the CH moieties in the imidazolium ring.	Hydrogen	125-133	C-C motif chemokine ligand 4	Homo sapiens	52-56
31384860-4	2019	It was revealed that the suppression of hydrogen bonding with water (N-HOH or NH-OH2) is the dominant factor for the fluorescence enhancement on the clay surface for NH2PhP and NMe2PhP.	Hydrogen	40-48	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	177-184
31279271-4	2019	Benefited from the structural advantages and the improvement of the absorption region, the optimized Co4S3/CdS (0.2) exhibits superior hydrogen production performance, and the amount of H2 reaches 5892.6 mumol h-1 g-1 under continuous visible-light illumination.	Hydrogen	135-143	CDP-diacylglycerol synthase 1	Homo sapiens	107-110
27549567-3	2016	Analyses of fluorescence and circular dichroism spectra indicated that the formation of the morin-alpha-glucosidase complex was driven mainly by hydrophobic forces and hydrogen bonding, and caused the conformational changes of alpha-glucosidase.	Hydrogen	168-176	sucrase-isomaltase	Homo sapiens	98-115
35318898-8	2022	The molecular dynamics simulation analysis revealed that the inhibitor 75 displayed binding stability in the active site of the FGFR4 by making two hydrogen bonds and one pi-cation interaction.	Hydrogen	148-156	fibroblast growth factor receptor 4	Homo sapiens	128-133
27549567-3	2016	Analyses of fluorescence and circular dichroism spectra indicated that the formation of the morin-alpha-glucosidase complex was driven mainly by hydrophobic forces and hydrogen bonding, and caused the conformational changes of alpha-glucosidase.	Hydrogen	168-176	sucrase-isomaltase	Homo sapiens	227-244
27569420-1	2016	The synthesis of a cobalt dihydrogen Co(I)-(H2) complex prepared from a Co(I)-(N2) precursor supported by a monoanionic pincer bis(carbene) ligand, (Mes)CCC ((Mes)CCC = bis(mesityl-benzimidazol-2-ylidene)phenyl), is described.	Hydrogen	43-47	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	37-42
27569420-1	2016	The synthesis of a cobalt dihydrogen Co(I)-(H2) complex prepared from a Co(I)-(N2) precursor supported by a monoanionic pincer bis(carbene) ligand, (Mes)CCC ((Mes)CCC = bis(mesityl-benzimidazol-2-ylidene)phenyl), is described.	Hydrogen	43-47	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	72-77
31279271-4	2019	Benefited from the structural advantages and the improvement of the absorption region, the optimized Co4S3/CdS (0.2) exhibits superior hydrogen production performance, and the amount of H2 reaches 5892.6 mumol h-1 g-1 under continuous visible-light illumination.	Hydrogen	186-188	CDP-diacylglycerol synthase 1	Homo sapiens	107-110
27569420-3	2016	Stoichiometric addition of HCl to the Co(I)-(N2) cleanly affords the Co(III) hydridochloride complex, which, upon the addition of Cp2ZrHCl, evolves hydrogen gas and regenerates the Co(I)-(N2) complex.	Hydrogen	148-156	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	38-43
35148100-5	2022	The interaction between ACE and Fru-His occurred spontaneously mainly through hydrogen bonding, and the process was accompanied by fluorescence quenching and the alteration of the secondary structure of ACE.	Hydrogen	78-86	zinc finger and BTB domain containing 22	Homo sapiens	32-35
27569420-3	2016	Stoichiometric addition of HCl to the Co(I)-(N2) cleanly affords the Co(III) hydridochloride complex, which, upon the addition of Cp2ZrHCl, evolves hydrogen gas and regenerates the Co(I)-(N2) complex.	Hydrogen	148-156	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	181-186
31618964-0	2019	Fabrication of Robust Hydrogen Evolution Reaction Electrocatalyst Using Ag2Se by Vacuum Evaporation.	Hydrogen	22-30	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	72-75
35148100-7	2022	Fru-His was attached to ACE"s S1 active pocket through hydrogen bonds and interacted with zinc ions in active sites.	Hydrogen	55-63	zinc finger and BTB domain containing 22	Homo sapiens	0-3
34742087-0	2022	Influence of organic molecules on wetting characteristics of mica/H2/brine systems: Implications for hydrogen structural trapping capacities.	Hydrogen	101-109	MHC class I polypeptide-related sequence A	Homo sapiens	61-65
31528971-2	2019	The in situ synthesized NiMoP phase in the feed for CH4-CO2 reforming can exhibit a higher activity compared to the one prepared in H2.	Hydrogen	132-134	complement C2	Homo sapiens	52-59
31490498-3	2019	Dimerization processes caused by hydrogen bonding or Ag(i)-carboxylate interactions in the solid state were observed for La-H2-PF6 and Ag2(La)2.	Hydrogen	33-41	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	135-143
31552973-0	2019	2D ultrathin CoP modified MnxCd1-xS with controllable band structure and robust photocatalytic performance for hydrogen generation.	Hydrogen	111-119	caspase recruitment domain family member 16	Homo sapiens	13-16
31552973-3	2019	An optimal H2 production rate of 65 324 mumol g-1 h-1 was obtained for the Mn0.5Cd0.5S/CoP-4% sample under visible light irradiation, which was 4.26 times higher than that of pure Mn0.5Cd0.5S as well as 38.7 times that of pure CdS.	Hydrogen	11-13	caspase recruitment domain family member 16	Homo sapiens	87-90
31432098-0	2019	Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	86-91
31264791-3	2019	Remarkably, Reside Lys126 formed hydrogen bond; residues Pro121, Val125, Tyr146, Tyr149 and Arg150 formed hydrophobic interaction, which are key amino acids within UCP1 site.	Hydrogen	33-41	uncoupling protein 1	Homo sapiens	164-168
31574107-8	2019	The perfusion rate was faster from the initial stage with hydrogen-containing cold ETK solution than with hydrogen-free ETK solution.	Hydrogen	106-114	BMX non-receptor tyrosine kinase	Homo sapiens	120-123
31506661-3	2019	Under alkaline condition, the C-CoP-1/12 exhibit splendid electrocatalytic performance with a low overpotential of 173 mV for hydrogen evolution reaction (HER) and 333 mV for oxygen evolution reaction (OER) at a current density of 10 mA cm-2.	Hydrogen	126-134	caspase recruitment domain family member 16	Homo sapiens	32-35
31461284-4	2019	The presence of electron-donating and hydrogen bond acceptor groups at position 4" of ring B could improve alpha-glucosidase activity.	Hydrogen	38-46	sucrase-isomaltase	Homo sapiens	107-124
31476119-2	2019	In this work, we report that tailoring of the 5d state of Pt1 single atoms on Co3O4 through strong electronic metal-support interactions (EMSIs) boosts the activity up to 68-fold higher than those on other supports in dehydrogenation of ammonia borane for room-temperature hydrogen generation.	Hydrogen	220-228	zinc finger protein 77	Homo sapiens	58-61
31476119-4	2019	Detailed spectroscopic characterization and theoretical calculations revealed that the EMSI tailors the unoccupied 5d state of Pt1 single atoms, which modulates the adsorption of ammonia borane and facilities hydrogen desorption, thus leading to the high activity.	Hydrogen	209-217	zinc finger protein 77	Homo sapiens	127-130
31514404-6	2019	Molecular docking results showed that three hydrogen bonds were formed between compound 18a and amino acids in the active site of alpha-glucosidase.	Hydrogen	44-52	sucrase-isomaltase	Homo sapiens	130-147
27506926-2	2016	METHODS AND RESULTS: We evaluated the impact of hs-TnT reporting on care and outcome among chest pain patients presenting to 5 emergency departments within a multicenter randomized trial.	Hydrogen	48-50	troponin T1, slow skeletal type	Homo sapiens	51-54
27587950-1	2016	The diagnostic and prognostic potential of an onco-metabolite, 2-hydroxyglutarate (2HG) as a proton magnetic resonance spectroscopy (1H-MRS) detectable biomarker of the isocitrate dehydrogenase (IDH)-mutated (IDH-MT) gliomas has drawn attention of neuroradiologists recently.	Hydrogen	133-135	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	169-193
27439590-5	2016	Results show that the photocatalytic turnover frequency (TOF), defined as moles of hydrogen produced per surface mole of Pt-Pd metal atom per second, for Pt-Pd nanocubes/CdS (Pt-Pd NCs/CdS) photocatalyst can be 3.4 times more effective than Pt-Pd nano-octahedra/CdS (Pt-Pd NOTa/CdS) nanocomposite photocatalyst.	Hydrogen	83-91	CDP-diacylglycerol synthase 1	Homo sapiens	170-173
27439590-5	2016	Results show that the photocatalytic turnover frequency (TOF), defined as moles of hydrogen produced per surface mole of Pt-Pd metal atom per second, for Pt-Pd nanocubes/CdS (Pt-Pd NCs/CdS) photocatalyst can be 3.4 times more effective than Pt-Pd nano-octahedra/CdS (Pt-Pd NOTa/CdS) nanocomposite photocatalyst.	Hydrogen	83-91	CDP-diacylglycerol synthase 1	Homo sapiens	185-188
27439590-5	2016	Results show that the photocatalytic turnover frequency (TOF), defined as moles of hydrogen produced per surface mole of Pt-Pd metal atom per second, for Pt-Pd nanocubes/CdS (Pt-Pd NCs/CdS) photocatalyst can be 3.4 times more effective than Pt-Pd nano-octahedra/CdS (Pt-Pd NOTa/CdS) nanocomposite photocatalyst.	Hydrogen	83-91	CDP-diacylglycerol synthase 1	Homo sapiens	185-188
27439590-5	2016	Results show that the photocatalytic turnover frequency (TOF), defined as moles of hydrogen produced per surface mole of Pt-Pd metal atom per second, for Pt-Pd nanocubes/CdS (Pt-Pd NCs/CdS) photocatalyst can be 3.4 times more effective than Pt-Pd nano-octahedra/CdS (Pt-Pd NOTa/CdS) nanocomposite photocatalyst.	Hydrogen	83-91	CDP-diacylglycerol synthase 1	Homo sapiens	185-188
27489114-6	2016	We show by mutagenesis, pulldown and hydrogen/deuterium exchange mass spectrometry that this peptide is a mimic for the conserved C-terminal tail of PP2A, an important region of the phosphatase which regulates holoenzyme assembly, and TIPRL preferentially binds the unmodified version of the PP2A-tail mimetic peptide DYFL compared to its tyrosine-phosphorylated version.	Hydrogen	37-45	protein phosphatase 2 phosphatase activator	Homo sapiens	149-153
27489114-6	2016	We show by mutagenesis, pulldown and hydrogen/deuterium exchange mass spectrometry that this peptide is a mimic for the conserved C-terminal tail of PP2A, an important region of the phosphatase which regulates holoenzyme assembly, and TIPRL preferentially binds the unmodified version of the PP2A-tail mimetic peptide DYFL compared to its tyrosine-phosphorylated version.	Hydrogen	37-45	TOR signaling pathway regulator	Homo sapiens	235-240
27489114-6	2016	We show by mutagenesis, pulldown and hydrogen/deuterium exchange mass spectrometry that this peptide is a mimic for the conserved C-terminal tail of PP2A, an important region of the phosphatase which regulates holoenzyme assembly, and TIPRL preferentially binds the unmodified version of the PP2A-tail mimetic peptide DYFL compared to its tyrosine-phosphorylated version.	Hydrogen	37-45	protein phosphatase 2 phosphatase activator	Homo sapiens	292-296
27477385-4	2016	In combination with new and existing structures of unmutated and affinity matured antibody Fab fragments, we used hydrogen/deuterium exchange with mass spectrometry to directly measure Fab structural dynamics.	Hydrogen	114-122	FA complementation group B	Homo sapiens	185-188
27236758-9	2016	Addition of nitrate increased hydrogen emissions (L/kg of DMI) quadratically by a factor of 2.5, 3.4, and 3.0 (as L/kg of DMI) for the low, medium, and high diets, respectively, compared with the control.	Hydrogen	30-38	DMI	Bos taurus	58-61
26194018-7	2016	Furthermore, molecular docking studies of the active products into the HNE binding site revealed two types of HNE inhibitors: molecules with cinnolin-4(1H)-one scaffold, which were attacked by the HNE Ser195 hydroxyl group at the amido moiety, and cinnoline derivatives containing an ester function at C-4, which is the point of attack of Ser195.	Hydrogen	152-154	complement C4A (Rodgers blood group)	Homo sapiens	302-305
27434555-0	2016	[Role of hydrogen gas in regulating of poly (ADP-ribose) polymerase-1 dependent cell death in rat Schwann cells].	Hydrogen	9-17	poly (ADP-ribose) polymerase 1	Rattus norvegicus	39-69
27434555-1	2016	OBJECTIVE: To investigate the protective effects and underlying molecular mechanisms of hydrogen (H2) on high glucose-induced poly (ADP-ribose) polymerase-1 (PARP-1) dependent cell death (PARthanatos) in primary rat Schwann cells.	Hydrogen	88-96	poly (ADP-ribose) polymerase 1	Rattus norvegicus	126-156
27434555-1	2016	OBJECTIVE: To investigate the protective effects and underlying molecular mechanisms of hydrogen (H2) on high glucose-induced poly (ADP-ribose) polymerase-1 (PARP-1) dependent cell death (PARthanatos) in primary rat Schwann cells.	Hydrogen	88-96	poly (ADP-ribose) polymerase 1	Rattus norvegicus	158-164
27434555-1	2016	OBJECTIVE: To investigate the protective effects and underlying molecular mechanisms of hydrogen (H2) on high glucose-induced poly (ADP-ribose) polymerase-1 (PARP-1) dependent cell death (PARthanatos) in primary rat Schwann cells.	Hydrogen	98-100	poly (ADP-ribose) polymerase 1	Rattus norvegicus	126-156
27434555-1	2016	OBJECTIVE: To investigate the protective effects and underlying molecular mechanisms of hydrogen (H2) on high glucose-induced poly (ADP-ribose) polymerase-1 (PARP-1) dependent cell death (PARthanatos) in primary rat Schwann cells.	Hydrogen	98-100	poly (ADP-ribose) polymerase 1	Rattus norvegicus	158-164
27045203-0	2016	MP2 Study of Physisorption of Molecular Hydrogen onto Defective Nanotubes: Cooperative Effect in Stone-Wales Defects.	Hydrogen	40-48	tryptase pseudogene 1	Homo sapiens	0-3
27045203-1	2016	We use large-scale MP2 calculations to investigate the physisorption of molecular hydrogen on (9,0) defective carbon nanotubes (CNTs) of C72H18.	Hydrogen	82-90	tryptase pseudogene 1	Homo sapiens	19-22
27327214-7	2016	However, for cis-1, this alignment coexists with another one that allows the simultaneous formation of two hydrogen bonds between the amide and the ester groups of adjacent molecules.	Hydrogen	107-115	suppressor of cytokine signaling 1	Homo sapiens	13-18
27043476-2	2016	Relative efficiencies of two major pathways were compared: production of 8-oxoguanine (8oxoG) and hydrogen abstraction from the DNA 2-deoxyribose moiety (dR) at C1," C4," and C5" positions.	Hydrogen	98-106	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	161-168
27285083-5	2016	In case of 4H(+), a rapid migration (in the NMR time scale) of the NH proton between two nitrogen atoms along the N-H   N hydrogen bond was registered at room temperature and frozen below -30  C with the proton fixed on the NMe2 group.	Hydrogen	122-130	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	224-228
27264884-2	2016	Therefore, the purpose of this study was to test the hypothesis that an acute 1h bout of hyperthermic treatment improves glucose, insulin, and leptin responses to an oral glucose challenge (OGTT) in obese type 2 diabetics and healthy humans.	Hydrogen	78-80	leptin	Homo sapiens	143-149
27143440-7	2016	A western blot analysis revealed that Res treatment at 1h before ischemia significantly increased ERK1/2 phosphorylation and cyclic-AMP response element binding protein (CREB) phosphorylation in the CA1 region of the hippocampus, which can be prevented with U0126 pretreatment.	Hydrogen	55-57	cAMP responsive element binding protein 1	Rattus norvegicus	125-168
27143440-7	2016	A western blot analysis revealed that Res treatment at 1h before ischemia significantly increased ERK1/2 phosphorylation and cyclic-AMP response element binding protein (CREB) phosphorylation in the CA1 region of the hippocampus, which can be prevented with U0126 pretreatment.	Hydrogen	55-57	carbonic anhydrase 1	Rattus norvegicus	199-202
27145339-4	2016	Homology modeling-based in silico docking of arctiin and arctigenin into the activity cavity of UGT2B15 showed that hydrogen bonds and hydrophobic interactions contributed to the strong binding free energy of arctiin (-8.14 kcal/mol) and arctigenin (-8.43 kcal/mol) with UGT2B15.	Hydrogen	116-124	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	96-103
27369531-5	2016	For the Ag-MOR and Cu-MOR zeolites, the iodine compounds are adsorbed preferentially in the large channel of mordenite (main channel) while water prefers the small channel or the side pocket where it forms stronger hydrogen bonds.	Hydrogen	215-223	opioid receptor mu 1	Homo sapiens	22-25
27237623-0	2016	MoS2/CdS Nanosheets-on-Nanorod Heterostructure for Highly Efficient Photocatalytic H2 Generation under Visible Light Irradiation.	Hydrogen	83-85	CDP-diacylglycerol synthase 1	Homo sapiens	5-8
27281194-6	2016	Both METTL3 and METTL14 adopt a class I MTase fold and they interact with each other via an extensive hydrogen bonding network, generating a positively charged groove.	Hydrogen	102-110	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	5-11
27283079-0	2016	Understanding divergent behaviors in the photocatalytic hydrogen evolution reaction on CdS and ZnS: a DFT based study.	Hydrogen	56-64	CDP-diacylglycerol synthase 1	Homo sapiens	87-90
27283079-1	2016	It has been a long time that divergent behaviors were observed in many photocatalytic hydrogen evolution reactions (HER) on CdS and ZnS although the two photocatalysts have similar compositions and structures.	Hydrogen	86-94	CDP-diacylglycerol synthase 1	Homo sapiens	124-127
27283079-2	2016	For example, CdS itself is inactive and loading of cocatalysts is indispensable to achieve high efficiency of hydrogen evolution, but the reverse is true for ZnS.	Hydrogen	110-118	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
27038284-4	2016	The Ag-MCP-1 nanocomposite can be used as an efficient heterogeneous catalyst in the reductive coupling of nitrobenzenes and alcohols using glycerol as hydrogen source.	Hydrogen	152-160	C-C motif chemokine ligand 2	Homo sapiens	7-12
27067109-4	2016	NMR hydrogen-deuterium exchange (HDX) experiments indicate the presence of partially unfolded forms (PUFs) of UCH-L1 under native conditions.	Hydrogen	4-12	ubiquitin C-terminal hydrolase L1	Homo sapiens	110-116
30155026-6	2016	Partial deprotonation of the imidazole moiety through hydrogen bonding interactions was then achieved by immobilizing the biomimetic model on hydrophobic C18 silica, which yielded an unprecedented insight on how this class of Cbl-dependent proteins may fine-tune their properties in biological systems.	Hydrogen	54-62	Cbl proto-oncogene	Homo sapiens	226-229
35084406-5	2022	All these properties make the CSHS a direct Z-scheme system with the hydrogen and oxygen evolution reactions occurring, respectively, at the CdS and SnS2 layers.	Hydrogen	69-77	sodium voltage-gated channel alpha subunit 11	Homo sapiens	149-153
27130107-1	2016	We present a SERS-based method for the detection of melamine utilizing multi-hydrogen bonding induced charge-transfer (CT) effects.	Hydrogen	77-85	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	13-17
35103263-4	2022	Here we describe the VCD spectroscopic characterization of the model peptide Boc-Val-Phe-nPr in chloroform as representative for a weakly interacting solvent and dimethyl sulfoxide (DMSO-d6) as a strongly hydrogen bonding solvent.	Hydrogen	205-213	neuronal pentraxin receptor	Homo sapiens	89-92
27040653-3	2016	The WS2-Pd composite film exhibits sensitivity (R 1/R 2, the ratio of the initial resistance to final resistance of the sensor) of 7.8 to 50,000 ppm hydrogen.	Hydrogen	149-157	CD1b molecule	Homo sapiens	48-55
35371538-2	2022	At 20 K for the O-H O hydrogen bond between the glycinium cation and the zwitterionic, unprotonated glycine mol-ecule that is associated with the ferroelectric behaviour of HTGS, O-H = 1.070 (3), H O = 1.408 (3) (delta = 0.338 (4)), O O = 2.4777 (15) A and O-H O = 179.0 (4) , which is in good agreement with previous studies.	Hydrogen	22-30	HTGS	Homo sapiens	173-177
26828288-9	2016	Molecular docking result suggested that santalin interact with the catalytic core of tyrosinase through strong hydrogen and hydrophobic bonding.	Hydrogen	111-119	tyrosinase	Mus musculus	85-95
26896627-10	2016	The NLRP3inh given 1h after reperfusion also significantly decreased caspase-1 activity and infarct size measured at 24h, whereas the NLRP3inh did not when given with a delay of 3h.	Hydrogen	19-21	NLR family, pyrin domain containing 3	Mus musculus	4-9
35072459-6	2022	We show that the FAD isoalloxazine ring is stabilized in the catalytic site of Bmp3 by strong hydrogen bonding with Asn123, Ile125, Ser126, and Thr158.	Hydrogen	94-102	bone morphogenetic protein 3	Homo sapiens	79-83
26896627-11	2016	CONCLUSIONS: Pharmacological inhibition of the NLRP3 inflammasome within 1h of reperfusion limits the secondary inflammatory injury and infarct size following myocardial ischemia-reperfusion in the mouse.	Hydrogen	73-75	NLR family, pyrin domain containing 3	Mus musculus	47-52
27081066-2	2016	The inelastic scattering cross section was resonantly enhanced by "gating" the frontier orbitals of water via a chlorine-terminated tip, so the hydrogen-bonding strength can be determined with high accuracy from the red shift in the oxygen-hydrogen stretching frequency of water.	Hydrogen	240-248	TOR signaling pathway regulator	Homo sapiens	132-135
26878108-0	2016	Tuning the hydrogen evolution activity of MS2 (M = Mo or Nb) monolayers by strain engineering.	Hydrogen	11-19	MS2	Homo sapiens	42-45
26878108-2	2016	Using first-principles calculations, we show that strain is also effective for tuning the catalytic activity of m-MS2 (M = Mo or Nb) towards the hydrogen evolution reaction (HER), which is essential for electrochemical hydrogen generation from water splitting.	Hydrogen	145-153	MS2	Homo sapiens	114-117
26878108-2	2016	Using first-principles calculations, we show that strain is also effective for tuning the catalytic activity of m-MS2 (M = Mo or Nb) towards the hydrogen evolution reaction (HER), which is essential for electrochemical hydrogen generation from water splitting.	Hydrogen	219-227	MS2	Homo sapiens	114-117
27010847-3	2016	Analysis of the crystal CGL structures bound to galactose, galactosamine, and globotriose Gb3 indicated that each CGL can bind three ligands through a carbohydrate-binding motif involving an extensive histidine- and water-mediated hydrogen bond network.	Hydrogen	231-239	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	90-93
27010847-4	2016	CGL binding to Gb3 is further enhanced by additional side-chain-mediated hydrogen bonds in each of the three ligand-binding sites.	Hydrogen	73-81	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	15-18
26725056-0	2016	1H, 13C and 15N backbone resonance assignment of the intrinsically disordered region of the nuclear envelope protein emerin.	Hydrogen	0-2	emerin	Homo sapiens	117-123
26725057-0	2016	1H, 13C and 15N resonance assignments of human DCL-1 (CD302) extracellular domain.	Hydrogen	0-2	CD302 molecule	Homo sapiens	47-52
26725057-0	2016	1H, 13C and 15N resonance assignments of human DCL-1 (CD302) extracellular domain.	Hydrogen	0-2	CD302 molecule	Homo sapiens	54-59
26849428-6	2016	Restricted side-chain dynamics are observed for a number of polar residues including K13, D22, E27, K31, D36, N37, D46, D47, K50, and E56, which we attribute to the effects of salt bridges and hydrogen bonds.	Hydrogen	193-201	keratin 13	Homo sapiens	85-88
26860583-4	2016	To gain structural information on these interactions, we used mass spectrometry to monitor hydrogen/deuterium exchange in various regions of FLASH, Lsm11 and NPAT alone or in the presence of their respective binding partners.	Hydrogen	91-99	nuclear protein, coactivator of histone transcription	Homo sapiens	158-162
26751813-2	2016	The highest hydrogen yield (0.80 molH2.molLactose(-1)) and productivity (660 mLH2 L(-1) d(-1)) were achieved for influent concentrations of 5400 mgDQO L(-1).	Hydrogen	12-20	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	77-81
26751813-4	2016	The lowest temperature tested (15  C) promoted the highest hydrogen yield and productivity (1.12 molH2 molLactose(-1) and 1080 mLH2 L(-1) d(-1)), and for the highest temperature (45  C), hydrogen production did not occur.	Hydrogen	59-67	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	127-131
26878435-2	2016	Reactive molecular dynamics simulations on a fully-dimensional potential energy surface fitted to MP2 calculations show that hydrogen transfer and HCl elimination compete with one another on the nanosecond time scale.	Hydrogen	125-133	tryptase pseudogene 1	Homo sapiens	98-101
26916429-10	2016	Multivariable Cox regression analysis suggested that hs-TnT is an independent factor for predicting in-hospital mortality risk (odds ratio: 2.202, 95% confidence interval: 1.111-4.367; P=0.024).	Hydrogen	53-55	troponin T1, slow skeletal type	Homo sapiens	56-59
26805749-5	2016	Catalysis results from combination of both electrostatic stabilization reducing the negative electron density on the PO3(=) oxygens and monoester dianion destabilization by the steric effects of close NMe3(+) groups hindering the hydrogen-bonding with water and destabilising the monoester dianion.	Hydrogen	230-238	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	201-205
26749447-1	2016	Fast gas-phase hydrogen/deuterium exchange mediated by ND3 gas and measured by mass spectrometry (gas-phase HDX-MS) is a largely unharnessed, fast, and sensitive method for probing primary- and higher-order polypeptide structure.	Hydrogen	15-23	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	55-58
26749447-2	2016	Labeling of heteroatom-bound non-amide hydrogens in a sub-millisecond time span after electrospray ionization by ND3 gas can provide structural insights into protein conformers present in solution.	Hydrogen	39-48	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	113-116
26574436-5	2016	By examining hydrogen-deuterium (H-D) exchange profiles, we show that part of the coiled-coil domain in the HPC2 Cterm forms a stable helix bundle regardless of the presence of Ca(2+).	Hydrogen	13-21	PCAP	Homo sapiens	108-112
26743813-2	2016	This species undergoes oxidative addition of H2 and silanes to give (MeNC3H2NPtBu2)RuH2(CO)(PPh3)2, (MeNC3H2NPtBu2)Ru H(SiRPh2)(CO)(PPh3) (R = Ph 5, H 6) and (MeNC3H2NPtBu2) RuH(PhSi(SCH2CH2)2O)(CO)(PPh3) .	Hydrogen	45-47	protein phosphatase 4 catalytic subunit	Homo sapiens	92-96
26743813-2	2016	This species undergoes oxidative addition of H2 and silanes to give (MeNC3H2NPtBu2)RuH2(CO)(PPh3)2, (MeNC3H2NPtBu2)Ru H(SiRPh2)(CO)(PPh3) (R = Ph 5, H 6) and (MeNC3H2NPtBu2) RuH(PhSi(SCH2CH2)2O)(CO)(PPh3) .	Hydrogen	45-47	protein phosphatase 4 catalytic subunit	Homo sapiens	132-136
26743813-2	2016	This species undergoes oxidative addition of H2 and silanes to give (MeNC3H2NPtBu2)RuH2(CO)(PPh3)2, (MeNC3H2NPtBu2)Ru H(SiRPh2)(CO)(PPh3) (R = Ph 5, H 6) and (MeNC3H2NPtBu2) RuH(PhSi(SCH2CH2)2O)(CO)(PPh3) .	Hydrogen	45-47	protein phosphatase 4 catalytic subunit	Homo sapiens	132-136
26506538-5	2016	PP2A activity had not manifested continued decline compare to 24h exposure and PP2A regulator alpha4 was found to release its associated PP2A/C since 1h exposure.	Hydrogen	150-152	protein phosphatase 2 phosphatase activator	Homo sapiens	79-83
26506538-5	2016	PP2A activity had not manifested continued decline compare to 24h exposure and PP2A regulator alpha4 was found to release its associated PP2A/C since 1h exposure.	Hydrogen	150-152	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	137-143
26506538-6	2016	The increasing of p-Akt-T308, p-Akt-S473, p-S6K1, p-S6, and p-4E-BP1 since 1h MC-LR exposure indicated that Akt/S6K1 cascade had been activated as early as 1h MC-LR treatment.	Hydrogen	75-77	ribosomal protein S6 kinase B1	Homo sapiens	112-116
26506538-6	2016	The increasing of p-Akt-T308, p-Akt-S473, p-S6K1, p-S6, and p-4E-BP1 since 1h MC-LR exposure indicated that Akt/S6K1 cascade had been activated as early as 1h MC-LR treatment.	Hydrogen	156-158	ribosomal protein S6 kinase B1	Homo sapiens	112-116
26725083-3	2016	The current work conceptualizes a model for the GPIHBP1 LPL interaction based on biophysical measurements with hydrogen-deuterium exchange/mass spectrometry, surface plasmon resonance, and zero-length cross-linking.	Hydrogen	111-119	lipoprotein lipase	Homo sapiens	56-59
26488087-0	2016	Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species.	Hydrogen	10-18	NLR family, pyrin domain containing 3	Mus musculus	57-62
26488087-4	2016	Due to the unique molecular structure, H2 can easily target the mitochondria, suggesting that H2 is a potential antagonist of mtROS-dependent NLRP3 inflammasome activation.	Hydrogen	39-41	NLR family, pyrin domain containing 3	Mus musculus	142-147
26488087-4	2016	Due to the unique molecular structure, H2 can easily target the mitochondria, suggesting that H2 is a potential antagonist of mtROS-dependent NLRP3 inflammasome activation.	Hydrogen	94-96	NLR family, pyrin domain containing 3	Mus musculus	142-147
26488087-5	2016	Here we have showed that, in mouse macrophages, H2 exhibited substantial inhibitory activity against LPS-initiated NLRP3 inflammasome activation by scavenging mtROS.	Hydrogen	48-50	NLR family, pyrin domain containing 3	Mus musculus	115-120
26488087-6	2016	Moreover, the elimination of mtROS by H2 resultantly inhibited mtROS-mediated NLRP3 deubiquitination, a non-transcriptional priming signal of NLRP3 in response to the stimulation of LPS.	Hydrogen	38-40	NLR family, pyrin domain containing 3	Mus musculus	78-83
26488087-6	2016	Moreover, the elimination of mtROS by H2 resultantly inhibited mtROS-mediated NLRP3 deubiquitination, a non-transcriptional priming signal of NLRP3 in response to the stimulation of LPS.	Hydrogen	38-40	NLR family, pyrin domain containing 3	Mus musculus	142-147
26488087-7	2016	Additionally, the removal of mtROS by H2 reduced the generation of oxidized mitochondrial DNA and consequently decreased its binding to NLRP3, thereby inhibiting the NLRP3 inflammasome activation.	Hydrogen	38-40	NLR family, pyrin domain containing 3	Mus musculus	136-141
26488087-7	2016	Additionally, the removal of mtROS by H2 reduced the generation of oxidized mitochondrial DNA and consequently decreased its binding to NLRP3, thereby inhibiting the NLRP3 inflammasome activation.	Hydrogen	38-40	NLR family, pyrin domain containing 3	Mus musculus	166-171
26488087-8	2016	Our findings have, for the first time, revealed the novel mechanism underlying the inhibitory effect of molecular hydrogen on LPS-caused NLRP3 inflammasome activation, highlighting the promising application of this new antioxidant in the treatment of LPS-associated inflammatory pathological damage.	Hydrogen	114-122	NLR family, pyrin domain containing 3	Mus musculus	137-142
26453880-6	2016	The DLMOs show the twisted model retains the same hydrogen bonding scheme as the flat model while minimizing steric interactions between H1 and H4".	Hydrogen	50-58	H1.5 linker histone, cluster member	Homo sapiens	137-147
27373636-1	2016	In this study, we designed and synthesized a structurally simplified syringolin A analogue 4, which could have a switched hydrogen bonding interaction with the beta5 subunit of 20S proteasome.	Hydrogen	122-130	adaptor related protein complex 5 subunit beta 1	Homo sapiens	160-165
26951145-6	2016	CONCLUSION: Structural analysis revealed that hydrogen bonds, salt bridges, pi-pi stacking and hydrophobic forces co-confer high stability and strong specificity to PKM2-inhibitor binding.	Hydrogen	46-54	pyruvate kinase M1/2	Homo sapiens	165-169
31492045-0	2019	New Insight on Hydrogen Evolution Reaction Activity of MoP2 from Theoretical Perspective.	Hydrogen	15-23	endothelial PAS domain protein 1	Homo sapiens	55-59
31492045-1	2019	We systematically investigated the hydrogen evolution reaction (HER) of six facets of MoP2 based on the periodic density functional theory (DFT).	Hydrogen	35-43	endothelial PAS domain protein 1	Homo sapiens	86-90
30193557-4	2019	Analyses on hydrogen bond interactions show that the decrease in hydrogen bonding interactions of residues R126 and Y128 with three inhibitors and the increase in that of K58 with inhibitors ZGC and IBP in the R126A mutated systems mostly regulate the conformational changes of A-FABP.	Hydrogen	12-20	fatty acid binding protein 4	Homo sapiens	278-284
31202914-8	2019	The interactions maintained with PD-L1 residues varied from hydrophobic interactions to hydrogen bonds and salt bridges with critical residues for PD-1/PD-L1 binding (M115, A121, Y123, I54, Y56, E58, R125).	Hydrogen	88-96	CD274 molecule	Homo sapiens	33-38
31202914-8	2019	The interactions maintained with PD-L1 residues varied from hydrophobic interactions to hydrogen bonds and salt bridges with critical residues for PD-1/PD-L1 binding (M115, A121, Y123, I54, Y56, E58, R125).	Hydrogen	88-96	CD274 molecule	Homo sapiens	152-157
31420591-5	2019	Furthermore, hydrogen/deuterium exchange mass spectrometric analysis reveals that the Fab portion of IgG1 is directly involved in its interaction with FcgammaRIIIa, in addition to the canonical Fc-mediated interaction.	Hydrogen	13-21	FA complementation group B	Homo sapiens	86-89
31176864-6	2019	Considering the structure natures of Ru2, conceivably except for electrostatic interaction, the forces stabilizing the triplex should also involve hydrophobic interaction and hydrogen bingding.	Hydrogen	175-183	doublecortin domain containing 2	Homo sapiens	37-40
31186139-3	2019	In the crystal structure of the nucleosome containing H2A.Z.1(S42R), the Arg residue inserted at the H2A.Z.1-Ser42 position forms additional hydrogen bonds and electrostatic interactions with the DNA backbone phosphates.	Hydrogen	141-149	H2A.Z variant histone 1	Homo sapiens	54-61
31186139-3	2019	In the crystal structure of the nucleosome containing H2A.Z.1(S42R), the Arg residue inserted at the H2A.Z.1-Ser42 position forms additional hydrogen bonds and electrostatic interactions with the DNA backbone phosphates.	Hydrogen	141-149	H2A.Z variant histone 1	Homo sapiens	101-108
31089833-5	2019	Meanwhile, Iba1+ microglial activation by status epilepticus was reduced by hydrogen treatment.	Hydrogen	76-84	allograft inflammatory factor 1	Rattus norvegicus	11-15
31147316-8	2019	Molecular docking manifested the generation of strong hydrogen-bonding interactions of Ser116 in CYP1A1 and Ser127 in CYP1B1 with methoxy moiety of NC.	Hydrogen	54-62	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	97-103
31262165-0	2019	Effective Electrocatalytic Hydrogen Evolution in Neutral Medium Based on 2D MoP/MoS2 Heterostructure Nanosheets.	Hydrogen	27-35	opioid receptor mu 1	Homo sapiens	76-79
31531194-2	2019	Inhibition of NIK by these compounds was found to be strongly dependent on the inclusion and absolute stereochemistry of a propargyl tertiary alcohol as it forms critical hydrogen bonds (H-bonds) with NIK.	Hydrogen	171-179	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	14-17
31531194-2	2019	Inhibition of NIK by these compounds was found to be strongly dependent on the inclusion and absolute stereochemistry of a propargyl tertiary alcohol as it forms critical hydrogen bonds (H-bonds) with NIK.	Hydrogen	171-179	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	201-204
31338599-6	2019	And then, the results of the MD simulation and the binding free energy decomposition verified that the binding of PI3Kdelta/inhibitors was mainly contributed from hydrogen bonding and hydrophobic interactions and some key residues for selective binding were highlighted.	Hydrogen	163-171	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	114-123
31074099-3	2019	W2 C/g-C3 N4 displays the highest activity for the photocatalytic reaction with a H2 evolution rate of up to 98 mumol h-1 , as well as remarkable recycling stability.	Hydrogen	82-84	H1.5 linker histone, cluster member	Homo sapiens	118-121
31087519-3	2019	Co-doped MoS2 (Co-MoS2 ) nanosheets are found to enable the highly efficient solar H2 evolution of CdS nanowires (NWs) in alkalescent electrolyte.	Hydrogen	83-85	CDP-diacylglycerol synthase 1	Homo sapiens	99-102
31244122-2	2019	In sum, we characterized two modes of bonding of [Zn2+-Tz] with CO2/H2O: the interaction is established through (i) a covalent bond between Zn2+ of [Zn2+-Tz] and oxygen atoms of CO2 or H2O and (ii) hydrogen bonds through N-H or C-H of [Zn2+-Tz] and oxygen atoms of H2O or CO2, N-H   O.	Hydrogen	198-206	complement C2	Homo sapiens	64-71
31155309-5	2019	Amino acid sequence conservation and published hydrogen-deuterium exchange data indicate repeats 3 through 6 to be a putative Galpha-binding surface.	Hydrogen	47-55	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	126-132
30990348-6	2019	Hydrogen-deuterium exchange/mass spectrometry analysis of dynamic structures of mAbs revealed the greater involvement of the terminal Gal residue on the Man alpha1-6 arm in the structural stability of the CH2 domain.	Hydrogen	0-8	adrenoceptor alpha 1D	Homo sapiens	157-165
30999003-3	2019	METHODS: The impact of circulating FABP4 on the cardiac neutral lipid content was measured by proton magnetic resonance spectroscopy (1H-MRS) in patients with type 2 diabetes.	Hydrogen	134-136	fatty acid binding protein 4	Homo sapiens	35-40
31144814-3	2019	This led us to develop a more drug-like diketopiperazine structure as a "hydrogen bond (H-bond) hunter" to target the substrate-binding site of SIRT2.	Hydrogen	73-81	sirtuin 2	Mus musculus	144-149
31020771-4	2019	Owing to the synergistic effect between NiO and CoFe layered double hydroxide, the hydrogen evolution reaction performance of the NCF was also improved.	Hydrogen	83-91	neutrophil cytosolic factor 4	Homo sapiens	130-133
26634958-4	2015	During the MD simulation, ArgP1 in a substrate accessed thrombin"s substrate-binding pocket and formed specific hydrogen bonds (H-bonds) with Asp189 in thrombin, while the catalytic serine of thrombin was still away from the substrate"s active site.	Hydrogen	112-120	diacylglycerol O-acyltransferase 1	Homo sapiens	26-31
26642257-0	2015	Ultrafine CoP Nanoparticles Supported on Carbon Nanotubes as Highly Active Electrocatalyst for Both Oxygen and Hydrogen Evolution in Basic Media.	Hydrogen	111-119	caspase recruitment domain family member 16	Homo sapiens	10-13
35149422-4	2022	A long hydrophobic alkyl chain (-nC16H33) was remotely linked to complex 2d, in which Carb-NHCs showed high electron-donating properties, and steric bulk with 1JCH constant of 1H NMR.	Hydrogen	176-178	syntaxin 8	Homo sapiens	86-90
26607471-9	2015	Moreover, brain-derived neurotrophic factor (BDNF) was up-regulated following 1h of ischemia and continued to increase initially during reperfusion but was down-regulated at later stages.	Hydrogen	78-80	brain derived neurotrophic factor	Mus musculus	10-43
26607471-9	2015	Moreover, brain-derived neurotrophic factor (BDNF) was up-regulated following 1h of ischemia and continued to increase initially during reperfusion but was down-regulated at later stages.	Hydrogen	78-80	brain derived neurotrophic factor	Mus musculus	45-49
26633377-11	2015	The complex models by docking simulation suggested that the intermolecular hydrogen bond via the nitrogen of thiourea and the contacts via thione were equally important for interacting with tyrosinase.	Hydrogen	75-83	tyrosinase	Mus musculus	190-200
30917654-5	2019	Binding isotherms of NA with alpha-syn species formed at different time points in the pathway have been observed to be exothermic in nature, suggesting hydrogen bonding interactions and weak affinity with binding constants in the millimolar range in all the cases.	Hydrogen	152-160	synuclein alpha	Homo sapiens	29-38
35091471-6	2022	In dalazatide-Kv1.3, binding of dalazatide to the channel"s outer vestibule narrows the selectivity filter, Y447 occupies a position seen in other K+ channels, and this conformation is stabilized by a network of intersubunit hydrogen bonds.	Hydrogen	225-233	potassium voltage-gated channel subfamily A member 3	Homo sapiens	14-19
31210236-0	2019	Low-cost high-performance hydrogen evolution electrocatalysts based on Pt-CoP polyhedra with low Pt loading in both alkaline and neutral media.	Hydrogen	26-34	caspase recruitment domain family member 16	Homo sapiens	74-77
26387473-2	2015	This study evaluates the influence of hs-TnT implementation on ED length of stay (LOS), consultations and admissions, as well as ED revisits with cardiology admissions for patients undergoing testing for suspected AMI.	Hydrogen	38-40	troponin T1, slow skeletal type	Homo sapiens	41-44
35174142-1	2021	A Reaction Class Transition State Theory (RC-TST) is applied to calculate thermal rate constants for hydrogen abstraction by OOH radical from alkanes in the temperature range of 300-2500 K. The rate constants for the reference reaction C2H6 +  OOH    C2H5 + H2O2, is obtained with the Canonical Variational Transition State Theory (CVT) augmented with the Small Curvature Tunneling (SCT) correction.	Hydrogen	101-109	twister	Drosophila melanogaster	45-48
26072680-3	2015	The results uncover that the essential interactions between key residues and covalent/non-covalent CD38 inhibitors include (i) hydrogen bond and hydrophobic interactions with residues Glu226 and Trp125, (ii) electrostatic or hydrogen bond interaction with the positively charged residue Arg127 region, and (iii) the hydrophobic interaction with residue Trp189.	Hydrogen	127-135	CD38 molecule	Homo sapiens	99-103
26072680-3	2015	The results uncover that the essential interactions between key residues and covalent/non-covalent CD38 inhibitors include (i) hydrogen bond and hydrophobic interactions with residues Glu226 and Trp125, (ii) electrostatic or hydrogen bond interaction with the positively charged residue Arg127 region, and (iii) the hydrophobic interaction with residue Trp189.	Hydrogen	225-233	CD38 molecule	Homo sapiens	99-103
26497733-0	2015	Enhance photoelectrochemical hydrogen-generation activity and stability of TiO2 nanorod arrays sensitized by PbS and CdS quantum dots under UV-visible light.	Hydrogen	29-37	CDP-diacylglycerol synthase 1	Homo sapiens	117-120
31139773-0	2019	Oxygen deficiency introduced to Z-scheme CdS/WO3-x nanomaterials with MoS2 as the cocatalyst towards enhancing visible-light-driven hydrogen evolution.	Hydrogen	132-140	CDP-diacylglycerol synthase 1	Homo sapiens	41-44
31139773-1	2019	An oxygen deficiency modified Z-scheme CdS/WO3-x nanohybrid with MoS2 as the cocatalyst was synthesized by a microwave hydrothermal method and was used for photocatalytic hydrogen production under visible light irradiation.	Hydrogen	171-179	CDP-diacylglycerol synthase 1	Homo sapiens	39-42
31139773-4	2019	The maximum hydrogen production of 2852.5 mumol g-1 h-1 was achieved, which was 5.5 times that of pure CdS (519.1 mumol g-1 h-1) and 1.5 times that of CdS/30 wt% WO3-x (1879.0 mumol g-1 h-1), and the external quantum efficiency (EQE) reached 10.0% at 420 nm.	Hydrogen	12-20	CDP-diacylglycerol synthase 1	Homo sapiens	103-106
31139773-4	2019	The maximum hydrogen production of 2852.5 mumol g-1 h-1 was achieved, which was 5.5 times that of pure CdS (519.1 mumol g-1 h-1) and 1.5 times that of CdS/30 wt% WO3-x (1879.0 mumol g-1 h-1), and the external quantum efficiency (EQE) reached 10.0% at 420 nm.	Hydrogen	12-20	CDP-diacylglycerol synthase 1	Homo sapiens	151-154
26629323-11	2015	A docking simulation between JAK3 inhibitor VI and the ATP-binding pocket of EGFR T790M/L858R predicted a potential binding status with hydrogen bonds.	Hydrogen	136-144	Janus kinase 3	Homo sapiens	29-33
31172036-2	2019	This study explores the functionality of a peptide mimic of the Notch ligand Jagged1 in a supramolecular system that is based on hydrogen bonding ureido-pyrimidinone (UPy) units.	Hydrogen	129-137	jagged canonical Notch ligand 1	Homo sapiens	77-84
35163950-4	2022	The isolated compounds were shown in an in silico setting to be accommodated well within the inhibitor-binding pockets of myeloperoxidase and inducible nitric oxide synthase and anchored mainly through hydrogen-bonding interactions and pi-effects.	Hydrogen	202-210	nitric oxide synthase, inducible	Meleagris gallopavo	142-173
31113492-11	2019	IHC and immunofluorescence staining demonstrated that hydrogen treatment markedly downregulated the expression of markers involved in stemness (CD133, Nestin), proliferation (ki67), and angiogenesis (CD34) and also upregulated GFAP expression, a marker of differentiation.	Hydrogen	54-62	CD34 antigen	Mus musculus	200-204
31113492-11	2019	IHC and immunofluorescence staining demonstrated that hydrogen treatment markedly downregulated the expression of markers involved in stemness (CD133, Nestin), proliferation (ki67), and angiogenesis (CD34) and also upregulated GFAP expression, a marker of differentiation.	Hydrogen	54-62	glial fibrillary acidic protein	Mus musculus	227-231
26356798-2	2015	In this report, scanning tunneling microscopy was used to study a Pt1-6/Fe3O4 model catalyst exposed to CO, H2, O2, and mixtures thereof at 550 K. CO extracts lattice oxygen atoms at the cluster perimeter to form CO2, creating large holes in the metal oxide surface.	Hydrogen	108-110	zinc finger protein 77	Homo sapiens	66-71
26254246-6	2015	Docking studies further authenticate that brazilein forms hydrophobic and hydrogen bonding with the active site residues of tyrosinase.	Hydrogen	74-82	tyrosinase	Mus musculus	124-134
35491020-4	2022	Complexation of ConA and CD206 with ligands is shown to be energetically caused by electrostatic interactions (E) of the charged residues (Asn, Asp, Arg) with oxygen and hydrogen atoms in carbohydrates; contributions of hydrophobic and van der Waals components is lower.	Hydrogen	170-178	mannose receptor C-type 1	Homo sapiens	25-30
26565604-7	2015	Docking analyses revealed that ligands bind in the large hydrophobic cavity of the kinase domain of MARK4 through several hydrophobic and hydrogen-bonded interactions.	Hydrogen	138-146	microtubule affinity regulating kinase 4	Homo sapiens	100-105
30987423-0	2019	Enhanced Visual Wireless Electrochemiluminescence Immunosensing of Prostate-Specific Antigen Based on the Luminol Loaded into MIL-53(Fe)-NH2 Accelerator and Hydrogen Evolution Reaction Mediation.	Hydrogen	157-165	kallikrein related peptidase 3	Homo sapiens	67-92
30987423-1	2019	A sensitive prostate-specific antigen (PSA) detection method using a visual-readout closed bipolar electrode (BPE) system has been introduced by integration of hydrogen evolution reaction (HER) in cathodic pole and electrochemiluminescence (ECL) of luminol loaded within the MIL-53(Fe)-NH2 (L@MIL-53(Fe)-NH2) in the anodic pole.	Hydrogen	160-168	kallikrein related peptidase 3	Homo sapiens	12-43
2620297-2	1989	Highly purified trehalase from pig renal cortex was found, in reactions monitored by 1H-n.m.r.	Hydrogen	85-87	trehalase	Sus scrofa	16-25
30995014-6	2019	A single 1H NMR signal assigned to the methyl groups of the ToM ligand suggested tridentate coordination of the ToM ligand to iron in 1 and 3.	Hydrogen	9-11	pre-mRNA processing factor 6	Homo sapiens	60-63
30995014-6	2019	A single 1H NMR signal assigned to the methyl groups of the ToM ligand suggested tridentate coordination of the ToM ligand to iron in 1 and 3.	Hydrogen	9-11	pre-mRNA processing factor 6	Homo sapiens	112-115
30950262-5	2019	Density functional theory calculations demonstrate that there is an interfacial effect between NiCoP and CoP, which allows a preferable hydrogen adsorption and thus contributes to the significantly enhanced performance.	Hydrogen	136-144	caspase recruitment domain family member 16	Homo sapiens	97-100
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Hydrogen	44-46	mutS homolog 6	Homo sapiens	90-94
30735837-11	2019	Thus, our data suggest that hydrogen may inhibit retinal senescence by suppressing the downregulation of Sirt3 expression through reduced oxidative stress reactions.	Hydrogen	28-36	sirtuin 3	Mus musculus	105-110
31097998-3	2019	The biased activity of ligands could be caused by the hydrogen-bonding interaction between ligands and CD1d according to the Th2-selective cytokine secretion and molecular docking studies.	Hydrogen	54-62	CD1d molecule	Homo sapiens	103-107
30957797-1	2019	A novel family of 2,6-bis[1-(p-dibenzocycloheptylarylimino)ethyl]pyridylcobalt dichlorides Co1-Co4 were synthesized and fully characterized by FT-IR, 1H NMR, and elemental analysis as well as X-ray diffraction analysis.	Hydrogen	150-152	complement C4A (Rodgers blood group)	Homo sapiens	95-98
31073393-12	2019	During 30 ns simulation, the candidate inhibitors established &lt;3.0 A root mean square deviation and stable hydrogen bond interactions with the ATP-binding site residues of Cdk5/p25.	Hydrogen	110-118	cyclin dependent kinase 5	Homo sapiens	175-179
30916046-1	2019	The synthesis is described of a pH-universal hydrogen evolution electrocatalyst based on N and P co-doped graphitic carbon encapsulated OsP2 (OsP2@NPC) nanoparticles of 1.8 nm size for the electrocatalytic hydrogen evolution reaction (HER).	Hydrogen	45-53	NPC intracellular cholesterol transporter 1	Homo sapiens	142-150
30758717-0	2019	1H, 13C, and 15N resonance assignments of the cytokine interleukin-36beta isoform-2.	Hydrogen	0-2	interleukin 36 beta	Homo sapiens	55-73
30827868-5	2019	The molecular modeling of 57 demonstrated that 57 bound well to the C-terminal ATP-binding pocket in the open conformation of the hHSP90 homodimer with hydrogen bonding and pi-cation interactions.	Hydrogen	152-160	heat shock protein 90 alpha family class A member 1	Homo sapiens	130-136
30708245-4	2019	Furthermore, the fairly high activity of H2 evolution of the resulting catalysts having low crystallinity and extremely strong optical properties is reveled in detail via investigating the dynamics of hydrogen generation of CoP and WP.	Hydrogen	41-43	caspase recruitment domain family member 16	Homo sapiens	224-227
30708245-4	2019	Furthermore, the fairly high activity of H2 evolution of the resulting catalysts having low crystallinity and extremely strong optical properties is reveled in detail via investigating the dynamics of hydrogen generation of CoP and WP.	Hydrogen	201-209	caspase recruitment domain family member 16	Homo sapiens	224-227
30708245-7	2019	These may be the main reasons why CoP and WP exhibit efficient H2 evolution activity.	Hydrogen	63-65	caspase recruitment domain family member 16	Homo sapiens	34-37
30708245-8	2019	In addition, the possible mechanism showing high photo-catalytic activity of hydrogen evolution for CoP and WP is proposed by a series of other characterizations, such as SEM, TEM, XPS, BET, transient photo-current response, steady-state fluorescence, transient-state fluorescence and Mott-Schottky studies etc.	Hydrogen	77-85	caspase recruitment domain family member 16	Homo sapiens	100-103
30502134-5	2019	During this process, hydrogen bond and hydrophobic forces play an important role in maintaining the binding interaction of CALB with phloridzin or its acetylated derivatives.	Hydrogen	21-29	calbindin 1	Homo sapiens	123-127
31049124-12	2019	In silico docking studies confirmed interaction between 2-AP and the adenosine A2a receptor through hydrogen bonds with the critical asparagine 253 residues present in the active site.	Hydrogen	100-108	adenosine A2a receptor	Homo sapiens	69-91
30893914-5	2019	Our data suggest a similar binding mode of micro-PIIIA at KV1.6 and KV1.1, in which a plethora of hydrogen bonds are formed by the Arg and Lys residues within the alpha-helical core region of micro-PIIIA, with the central pore residues of the channel.	Hydrogen	98-106	potassium voltage-gated channel subfamily A member 1	Homo sapiens	68-73
30785438-0	2019	Enhanced photocatalytic hydrogen evolution over bimetallic zeolite imidazole framework-encapsulated CdS nanorods.	Hydrogen	24-32	CDP-diacylglycerol synthase 1	Homo sapiens	100-103
30857151-0	2019	Photoelectrocatalytic Hydrogen Generation Enabled by CdS Passivated ZnCuInSe Quantum Dot-Sensitized TiO2 Decorated with Ag Nanoparticles.	Hydrogen	22-30	CDP-diacylglycerol synthase 1	Homo sapiens	53-56
30857151-1	2019	Here we present the photoelectrocatalytic hydrogen generation properties of CdS passivated ZnCuInSe (ZCISe) quantum dots (QDs) supported by TiO2 nanowires decorated with Ag nanoparticles.	Hydrogen	42-50	CDP-diacylglycerol synthase 1	Homo sapiens	76-79
30984338-4	2019	We found that H2-O2 mixture inhalation declined ER stress-induced apoptosis via three major response pathways: PERK-eIF2alpha-ATF4, IRE 1-XBP1, and ATF 6.	Hydrogen	14-16	X-box binding protein 1	Rattus norvegicus	138-142
30984338-4	2019	We found that H2-O2 mixture inhalation declined ER stress-induced apoptosis via three major response pathways: PERK-eIF2alpha-ATF4, IRE 1-XBP1, and ATF 6.	Hydrogen	14-16	activating transcription factor 6	Rattus norvegicus	148-153
30566365-7	2019	The CIP domain involved in C3d binding was mapped via hydrogen deuterium exchange-mass spectrometry.	Hydrogen	54-62	endogenous retrovirus group K member 13	Homo sapiens	27-30
30591589-8	2019	Therefore, we used hydrogen-deuterium exchange MS to identify potential binding sites between LPL and ANGPTL4.	Hydrogen	19-27	lipoprotein lipase	Homo sapiens	94-97
30591589-8	2019	Therefore, we used hydrogen-deuterium exchange MS to identify potential binding sites between LPL and ANGPTL4.	Hydrogen	19-27	angiopoietin like 4	Homo sapiens	102-109
30791611-3	2019	The aim of this study was to determine whether metabolic reprogramming associated with IDH mutant gliomas leads to additional 1H MRS-detectable differences between IDH1 and IDH2 mutations, and to identify metabolites correlated with 2-HG.	Hydrogen	126-128	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	87-90
30791611-3	2019	The aim of this study was to determine whether metabolic reprogramming associated with IDH mutant gliomas leads to additional 1H MRS-detectable differences between IDH1 and IDH2 mutations, and to identify metabolites correlated with 2-HG.	Hydrogen	126-128	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	164-168
30677669-5	2019	Moreover, the docking studies were carried out to prove that the four compounds could interact with the hydrophobic region of the active pocket and form hydrogen bonds to enhance the binding affinity of them with the alpha-glucosidase.	Hydrogen	153-161	sucrase isomaltase (alpha-glucosidase)	Mus musculus	217-234
30996942-4	2019	CdS deposited anisotropic Pt-tipped Au nanorods, which feature improved light absorption, structure-enhanced electric field distribution and spatially regulated multichannel charge transfer, show distinctly higher photoactivity than blank CdS and other metal-CdS hybrids for simultaneous H2 and value-added aldehyde production from one redox cycle.	Hydrogen	288-290	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
30607953-5	2019	The static view indicates that the hydrogen bonds involving Pin1 rearrange in a tightly coupled manner with isomerization.	Hydrogen	35-43	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	60-64
30342342-0	2019	Excited state hydrogen atom transfer in micro-solvated dicoumarol: A TDDFT/EFP1 study.	Hydrogen	14-22	thioredoxin domain containing 11	Homo sapiens	75-79
30504654-5	2019	The docking results showed that hydrogen bonds were generated between the test compounds and alpha-glucosidase.	Hydrogen	32-40	sucrase-isomaltase	Homo sapiens	93-110
30252533-7	2019	Instead, sodium-hydrogen exchanger type 3 levels in the proximal tubule were dramatically reduced in Epac1-/- and Epac2-/- mice.	Hydrogen	16-24	Rap guanine nucleotide exchange factor (GEF) 4	Mus musculus	114-119
30252533-10	2019	Deletion of Epac1 and Epac2 decreases sodium-hydrogen exchanger type 3 expression in the proximal tubule, leading to polyuria and osmotic diuresis.-Cherezova, A., Tomilin, V., Buncha, V., Zaika, O., Ortiz, P. A., Mei, F., Cheng, X., Mamenko, M., Pochynyuk, O. Urinary concentrating defect in mice lacking Epac1 or Epac2.	Hydrogen	45-53	Rap guanine nucleotide exchange factor (GEF) 4	Mus musculus	22-27
30227201-5	2019	And the formation of the rifampicin-alpha-glucosidase complex was driven spontaneously by hydrophobic forces and hydrogen bonds.	Hydrogen	113-121	sucrase-isomaltase	Homo sapiens	36-53
30227201-6	2019	The results obtained from molecular docking further indicated that hydrophobic forces were formed between rifampicin and amino acid residues Phe 173, Pro151, and hydrogen bonds were generated by the interactions of rifampicin with residues Ser 180, Asn 414, Gly160, and Gly161 of alpha-glucosidase.	Hydrogen	162-170	sucrase-isomaltase	Homo sapiens	280-297
29310523-8	2019	Hydrogen bond occupancy of NS7 and NS9 generated from MD trajectories showed good interaction with the flap residues Gln73, Thr72 of BACE-1 and Arg141, Thr138 residues of GSK-3beta.	Hydrogen	0-8	SOS Ras/Rho guanine nucleotide exchange factor 2	Homo sapiens	35-38
29338614-8	2019	The wild and mutated actins docked with myosin showed differences in hydrogen bonding patterns, free binding energies, and hydrogen bond occupation frequencies.	Hydrogen	69-77	myosin heavy chain 14	Homo sapiens	40-46
29338614-8	2019	The wild and mutated actins docked with myosin showed differences in hydrogen bonding patterns, free binding energies, and hydrogen bond occupation frequencies.	Hydrogen	123-131	myosin heavy chain 14	Homo sapiens	40-46
31250600-15	2019	MPO activity in lung tissue was significantly reduced along with decreased productions of TNF-alpha and IL-6, and an increased production of IL-10 in the presence of hydrogen (all P&lt;0.05), demonstrating antioxidant and anti-inflammatory effect of hydrogen in NaHS-induced ALI.	Hydrogen	166-174	myeloperoxidase	Rattus norvegicus	0-3
31250600-15	2019	MPO activity in lung tissue was significantly reduced along with decreased productions of TNF-alpha and IL-6, and an increased production of IL-10 in the presence of hydrogen (all P&lt;0.05), demonstrating antioxidant and anti-inflammatory effect of hydrogen in NaHS-induced ALI.	Hydrogen	166-174	interleukin 10	Rattus norvegicus	141-146
31250600-15	2019	MPO activity in lung tissue was significantly reduced along with decreased productions of TNF-alpha and IL-6, and an increased production of IL-10 in the presence of hydrogen (all P&lt;0.05), demonstrating antioxidant and anti-inflammatory effect of hydrogen in NaHS-induced ALI.	Hydrogen	250-258	myeloperoxidase	Rattus norvegicus	0-3
30643909-1	2019	Here, we show a two-liquid interfacial 3D plasmonic array for SERS examination on direct photoreduction of p-nitrothiophenol (4-NTP) to p-aminothiophenol (4-ATP) without the need for traditional catalysts and reductants, revealing the mechanism of halide-assisted activation of atomic hydrogen and the balance between the enhancing effect from etching of the Ag surface and the weakening effect from the reduction of the 4-NTP molecules, which provides insights into the light-to-energy conversion schemes on noble metal surfaces.	Hydrogen	285-293	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	62-66
29697952-0	2019	In Situ Synthesis of CdS/Graphdiyne Heterojunction for Enhanced Photocatalytic Activity of Hydrogen Production.	Hydrogen	91-99	CDP-diacylglycerol synthase 1	Homo sapiens	21-24
30605203-2	2019	The resultant Ru-NGC possesses superior hydrogen evolution activity with a small onset potential of 9.5 mV and excellent durability due to the optimized Ru electronic state in nitrogen-doped graphite.	Hydrogen	40-48	chondroitin sulfate proteoglycan 5	Homo sapiens	17-20
30907314-9	2019	The expression levels of p- JAK2/JAK2, p-STAT3/STAT3 were upregulated in the hydrogen-rich water group compared with the control group, and p-STAT1/STAT1 was downregulated in the hydrogen-rich water group compared with the control group.	Hydrogen	77-85	signal transducer and activator of transcription 3	Rattus norvegicus	41-46
30907314-9	2019	The expression levels of p- JAK2/JAK2, p-STAT3/STAT3 were upregulated in the hydrogen-rich water group compared with the control group, and p-STAT1/STAT1 was downregulated in the hydrogen-rich water group compared with the control group.	Hydrogen	77-85	signal transducer and activator of transcription 3	Rattus norvegicus	47-52
30907314-11	2019	CONCLUSION: Hydrogen-rich water may inhibit the apoptosis of cardiomyocytes after ischaemia-reperfusion by upregulating the expression of the JAK2-STAT3 signalling pathway, which reduces ischaemia-reperfusion injury.	Hydrogen	12-20	signal transducer and activator of transcription 3	Rattus norvegicus	147-152
30387805-9	2019	Computational docking suggested that there are three or four possible hydrogen bonds in the active pocket of AKT1 and AKT2 that contribute to the mode of action of resveratrol.	Hydrogen	70-78	AKT serine/threonine kinase 2	Homo sapiens	118-122
30609653-5	2019	VKORC1 was shown to tightly bind vitamins K1 and MK4 in the epoxide and quinone states, but not in the hydroquinone state; five VKORC1 residues were identified as crucial for vitamin K stabilization, and two other ones were essential for hydrogen bond formation.	Hydrogen	238-246	vitamin K epoxide reductase complex subunit 1	Homo sapiens	0-6
30599736-0	2018	Solving the Schrodinger equation of hydrogen molecule with the free complement-local Schrodinger equation method: Potential energy curves of the ground and singly excited singlet and triplet states, Sigma, Pi, Delta, and Phi.	Hydrogen	36-44	vasoactive intestinal peptide	Sus scrofa	221-224
30480694-2	2018	We report that various low-temperature annealing conditions (340, 360, 380, and 400  C) under hydrogen gas flow convert beta-FeOOH into magnetite (Fe3O4) as well as introduce Sn4+ diffusion from FTO substrates to its surface.	Hydrogen	94-102	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	195-198
30328634-3	2018	By using poly(acrylic acid) (PAA) as a model system, we demonstrate selective filtering of the signals of typical low-R2p species (insensitive to Gd3+ ), such as molecular/polymeric cations and non-ionic polymers, which, through PAA recognition (electrostatic/hydrogen-bonding interactions), become exposed to the paramagnetic effect of Gd3+ , while leaving non-PAA-interacting species unaffected.	Hydrogen	260-268	ribonucleotide reductase regulatory subunit M2	Homo sapiens	118-121
30564979-4	2018	The geometries of pi stacking and hydrogen bond interactions between two 2-amino-4-nitrophenols were optimized at BLYP-D3/def2-QZVP with dispersion 3 and MP2/cc-pVTZ levels of theory, and their stability was compared using the CCSD(T) interaction energies.	Hydrogen	34-42	tryptase pseudogene 1	Homo sapiens	154-157
30388370-5	2018	Using quantum chemical calculations at the MP2/6-31++g(d,p) level, NO2  is shown capable of abstracting a hydrogen atom from the phenolic group on the aromatic ring.	Hydrogen	106-114	tryptase pseudogene 1	Homo sapiens	43-46
30130471-4	2018	Molecular docking simulation revealed that quercetin-7-O-alpha-L-rhamnoside inhibits tyrosinase activity by hydrogen bonding with residues His85, His244, Thr261, and Gly281 of tyrosinase.	Hydrogen	108-116	tyrosinase	Mus musculus	85-95
30248540-10	2018	Specifically, docking of SSD to the crystal structure of beta-catenin suggested that SSD interacted with beta-catenin via hydrogen bonds and hydrophobic interaction.	Hydrogen	122-130	catenin beta 1	Homo sapiens	57-69
30248540-10	2018	Specifically, docking of SSD to the crystal structure of beta-catenin suggested that SSD interacted with beta-catenin via hydrogen bonds and hydrophobic interaction.	Hydrogen	122-130	catenin beta 1	Homo sapiens	105-117
31950709-4	2018	Comparison of isostructural partially fluorinated benzotriphenylenes, 2,3-TRPH(C4 F4 ) and 2,3-TRPH(C4 HF3 ), revealed an unexpectedly large (30 %) drop of pi-pi overlap, when only one fluorine atom was replaced with the hydrogen atom in a C4 F4 moiety.	Hydrogen	221-229	tryptophan hydroxylase 1	Homo sapiens	74-84
29683360-0	2018	Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Abeta clearance.	Hydrogen	0-8	presenilin 1	Mus musculus	76-79
29683360-2	2018	Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Abeta injection-induced cognitive dysfunction.	Hydrogen	10-18	amyloid beta (A4) precursor protein	Mus musculus	156-161
29683360-5	2018	We found that hydrogen-rich water significantly improved cognitive behaviour in female transgenic AD mice without affecting Abeta clearance, and reversed the brain oestrogen level, ERbeta, and brain-derived neurotrophic factor (BDNF) expressions that were damaged in female transgenic AD mice, but not in males.	Hydrogen	14-22	amyloid beta (A4) precursor protein	Mus musculus	124-129
29683360-5	2018	We found that hydrogen-rich water significantly improved cognitive behaviour in female transgenic AD mice without affecting Abeta clearance, and reversed the brain oestrogen level, ERbeta, and brain-derived neurotrophic factor (BDNF) expressions that were damaged in female transgenic AD mice, but not in males.	Hydrogen	14-22	Era (G-protein)-like 1 (E. coli)	Mus musculus	181-187
29683360-5	2018	We found that hydrogen-rich water significantly improved cognitive behaviour in female transgenic AD mice without affecting Abeta clearance, and reversed the brain oestrogen level, ERbeta, and brain-derived neurotrophic factor (BDNF) expressions that were damaged in female transgenic AD mice, but not in males.	Hydrogen	14-22	brain derived neurotrophic factor	Mus musculus	193-226
29683360-5	2018	We found that hydrogen-rich water significantly improved cognitive behaviour in female transgenic AD mice without affecting Abeta clearance, and reversed the brain oestrogen level, ERbeta, and brain-derived neurotrophic factor (BDNF) expressions that were damaged in female transgenic AD mice, but not in males.	Hydrogen	14-22	brain derived neurotrophic factor	Mus musculus	228-232
29683360-7	2018	Our results demonstrate a novel sex-specific beneficial effect of hydrogen via oestrogen and brain ERbeta-BDNF signalling in AD pathogenesis.	Hydrogen	66-74	Era (G-protein)-like 1 (E. coli)	Mus musculus	99-105
29683360-7	2018	Our results demonstrate a novel sex-specific beneficial effect of hydrogen via oestrogen and brain ERbeta-BDNF signalling in AD pathogenesis.	Hydrogen	66-74	brain derived neurotrophic factor	Mus musculus	106-110
30243702-12	2018	Otherwise, exercise caused an increased CREB phosphorylation which was attenuated by H2.	Hydrogen	85-87	cAMP responsive element binding protein 1	Rattus norvegicus	40-44
30320326-0	2018	Size-controlled synthesis of CdS nanoparticles confined on covalent triazine-based frameworks for durable photocatalytic hydrogen evolution under visible light.	Hydrogen	121-129	CDP-diacylglycerol synthase 1	Homo sapiens	29-32
30350604-3	2018	The Cy3-CD63 aptamer can be selectively adsorbed onto the Ti3C2 MXene nanosheets by hydrogen bond and metal chelate interaction between the aptamer and MXenes, and the fluorescence signal from Cy3-CD63 aptamer was quenched quickly owing to the FRET between the Cy3 and MXenes.	Hydrogen	84-92	CD63 molecule	Homo sapiens	8-12
30350604-3	2018	The Cy3-CD63 aptamer can be selectively adsorbed onto the Ti3C2 MXene nanosheets by hydrogen bond and metal chelate interaction between the aptamer and MXenes, and the fluorescence signal from Cy3-CD63 aptamer was quenched quickly owing to the FRET between the Cy3 and MXenes.	Hydrogen	84-92	CD63 molecule	Homo sapiens	197-201
30238677-2	2018	Significantly lower overpotentials are required for PdP2 @CB (27.5 mV in 0.5 m H2 SO4 ; 35.4 mV in 1 m KOH; 84.6 mV in 1 m PBS) to achieve a HER electrocatalytic current density of 10 mA cm-2 compared to commercial Pt/CB (30.1 mV in 0.5 m H2 SO4 ; 46.6 mV in 1 m KOH; 122.7 mV in 1 m PBS).	Hydrogen	79-81	pyruvate dehydrogenase phosphatase catalytic subunit 2	Homo sapiens	52-56
30167931-8	2018	Some structural features are highly conserved in the two isozymes, such as a Tyr-Tyr aromatic sandwich in front of the flavin ring and a Lys residue hydrogen-bonded to the cofactor N5 atom, whereas a pair of gating residues (Phe208/Ile335 in MAO A; Ile199/Tyr326 in MAO B) specifically determines the different substrate and inhibitor properties of the two enzymes.	Hydrogen	149-157	monoamine oxidase A	Homo sapiens	242-247
30328852-3	2018	Here, we report the results of neutron-diffraction experiments that observed transitions from metastable to stable structures in the D2-D2O system around 0.2-0.3 GPa between 130 K and 280 K. These metastable structures were observed in the stability region of the sII hydrogen hydrate clathrate and computational studies of their relative enthalpies suggest that transition sequence observed is in line with Ostwald"s "Rule of Stages".	Hydrogen	268-276	transcription elongation factor A1	Homo sapiens	264-267
30384428-2	2018	Based on the crystal structure of TGFbetaR1-BMS22 complex, the pharmacophore model A02 with two hydrogen bond acceptors (HBAs) and four hydrophobic (HYD) properties was constructed.	Hydrogen	96-104	transforming growth factor beta receptor 1	Homo sapiens	34-43
30205977-11	2018	Based on these findings, we propose that during local yield events, OC and OPN rely on ionic interactions of their charged side chains and on hydrogen bonding to dissipate energy in bone.	Hydrogen	142-150	bone gamma-carboxyglutamate protein 2	Mus musculus	68-70
30095192-4	2018	It has been revealed that the best composite (40 % GPP@CdS composite) exhibits hydrogen production activity of 1321 mumol, which exceeds that of CdS by a factor of more than two, and can be used in at least seven cycles with negligible loss of activity.	Hydrogen	79-87	CDP-diacylglycerol synthase 1	Homo sapiens	55-58
30199250-4	2018	The hydrogen transfer process in the oxidative addition step is rate-determining in the whole catalytic cycle, which is accomplished by C-Ha (active Ha) activation without generating the high energy nickel hydride intermediate.	Hydrogen	4-12	transcription factor like 5	Homo sapiens	136-140
29842959-3	2018	In this study, homology models of JAK2 demonstrated that F556 located between two threonine residues which interacted with ATP phosphate groups by hydrogen bonds, Thr555 with the gamma-phosphate and Thr557 with the beta-phosphate in the active site of JAK2"s JH2 domain.	Hydrogen	147-155	Janus kinase 2	Mus musculus	34-38
30192127-6	2018	The ultrasmall grain size (5 nm) and narrow interface gap (&lt;2 nm) controlled by Ar+ plasma bombardment enabled both the hydrogen-induced lattice expansion (HILE) (Delta RH2 &lt; 0) and surface electron scattering (Delta RH2 &gt; 0) mechanisms to be simultaneously applied to the single Pd channel, thereby inducing dual-switching response according to the H2 concentration range.	Hydrogen	123-131	Rh associated glycoprotein	Homo sapiens	172-175
30192127-6	2018	The ultrasmall grain size (5 nm) and narrow interface gap (&lt;2 nm) controlled by Ar+ plasma bombardment enabled both the hydrogen-induced lattice expansion (HILE) (Delta RH2 &lt; 0) and surface electron scattering (Delta RH2 &gt; 0) mechanisms to be simultaneously applied to the single Pd channel, thereby inducing dual-switching response according to the H2 concentration range.	Hydrogen	123-131	Rh associated glycoprotein	Homo sapiens	223-226
30232347-0	2018	Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression.	Hydrogen	10-18	sirtuin 1	Mus musculus	117-122
30232347-9	2018	Moreover, the expression of Bcl-2, HO-1, and Sirt1 in liver, KCs, and hepatocytes by hydrogen gas were increased, whereas caspase activation, Bax, and acetylation of p53 were suppressed by hydrogen gas.	Hydrogen	85-93	sirtuin 1	Mus musculus	45-50
30232347-9	2018	Moreover, the expression of Bcl-2, HO-1, and Sirt1 in liver, KCs, and hepatocytes by hydrogen gas were increased, whereas caspase activation, Bax, and acetylation of p53 were suppressed by hydrogen gas.	Hydrogen	189-197	sirtuin 1	Mus musculus	45-50
30232347-9	2018	Moreover, the expression of Bcl-2, HO-1, and Sirt1 in liver, KCs, and hepatocytes by hydrogen gas were increased, whereas caspase activation, Bax, and acetylation of p53 were suppressed by hydrogen gas.	Hydrogen	189-197	transformation related protein 53, pseudogene	Mus musculus	166-169
30232347-10	2018	These results demonstrated that H2 treatment ameliorated I/R liver injury in a fatty liver model by reducing hepatocyte apoptosis, inhibiting macrophage activation and inflammatory cytokines, and inducing HO-1 and Sirt1 expression.	Hydrogen	32-34	sirtuin 1	Mus musculus	214-219
30031006-3	2018	We describe using an integrated electron microscopy and hydrogen-deuterium exchange mass spectrometry (HDX-MS) approach to probe the architecture and dynamics of the complex of PI4KIIIalpha/TTC7/FAM126.	Hydrogen	56-64	tetratricopeptide repeat domain 7A	Homo sapiens	190-194
30045870-8	2018	Moreover, we found that ADPR is buried in a groove and forms multiple hydrogen bonds with the main chain and side chains of ARH3 residues.	Hydrogen	70-78	ADP-ribosylserine hydrolase	Homo sapiens	124-128
29853075-1	2018	New morpholine derived Schiff base ligands (HL1 and HL2) and their Cu(II) complexes [Cu(L1)2] (1) and [Cu(L2)2] (2) have been synthesized and characterized by 1H NMR, IR, UV-Vis, EPR studies and cyclic voltammetric analyses.	Hydrogen	159-161	intelectin 1	Homo sapiens	44-47
30068074-2	2018	In addition, TTF + was electrochemically reduced back to TTF on a carbon electrode, to be further protonated to continuously produce H2 photochemically.	Hydrogen	133-135	ras homolog family member H	Homo sapiens	13-16
30068074-2	2018	In addition, TTF + was electrochemically reduced back to TTF on a carbon electrode, to be further protonated to continuously produce H2 photochemically.	Hydrogen	133-135	ras homolog family member H	Homo sapiens	57-60
30356966-4	2018	In addition, the Fe-CoP/NF can also function as a highly active electrocatalyst for hydrogen evolution reaction with a low overpotential of 78 mV at 10 mA cm-2 current density in alkaline solution.	Hydrogen	84-92	caspase recruitment domain family member 16	Homo sapiens	20-23
30040391-6	2018	Further reduction of the Co(I) complex was found to generate a pincer-based pi-radical anion that demonstrated well-resolved EPR features to the four hydrogen atoms and lone nitrogen atom of the ligand with minor contributions from cobalt and coordinated N2.	Hydrogen	150-158	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	25-30
30028452-3	2018	Benefiting from the strong coupling and synergistic effect between CoP QDs and highly conductive S,N-codoped carbon, well-structured porosity and high specific surface area, the resulting CoP@SNC exhibits excellent activities for oxygen evolution reaction (OER), hydrogen evolution reaction (HER), and oxygen reduction reaction (ORR), making it a trifunctional electro-catalyst for overall water splitting and rechargeable Zn-air batteries.	Hydrogen	263-271	caspase recruitment domain family member 16	Homo sapiens	188-191
30061486-0	2018	N,P-Codoped Carbon Layer Coupled with MoP Nanoparticles as an Efficient Electrocatalyst for Hydrogen Evolution Reaction.	Hydrogen	92-100	opioid receptor mu 1	Homo sapiens	38-41
30061486-3	2018	The obtained MoP/NPCs presented efficient activity for hydrogen evolution reaction (HER), with low onset potential of 90 mV, and a small Tafel slope (71 mV dec-1), as well as extraordinary stability in acidic electrolyte.	Hydrogen	55-63	opioid receptor mu 1	Homo sapiens	13-16
29925531-5	2018	Our results show that NUPR1L was an oligomeric IDP from pH 2.0 to 12.0, as judged by steady-state fluorescence, circular dichroism (CD), dynamic light scattering, 1D 1H-NMR (nuclear magnetic resonance), and as indicated by structural modelling.	Hydrogen	166-168	nuclear protein 2, transcriptional regulator	Homo sapiens	22-28
29949370-5	2018	There are positive shifts of 290 and 260 mV, respectively, for the CoII/CoI and CoIII-H/CoII-H couples from [Co(DPA-1-MPI)(H2O)](PF6)3 to [Co(DPA-3-MPI)(H2O)](PF6)3, with the former being ~32 times as active as the latter in photocatalytic H2 production.	Hydrogen	123-125	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	67-70
29949370-5	2018	There are positive shifts of 290 and 260 mV, respectively, for the CoII/CoI and CoIII-H/CoII-H couples from [Co(DPA-1-MPI)(H2O)](PF6)3 to [Co(DPA-3-MPI)(H2O)](PF6)3, with the former being ~32 times as active as the latter in photocatalytic H2 production.	Hydrogen	123-125	mannose phosphate isomerase	Homo sapiens	118-121
29949370-5	2018	There are positive shifts of 290 and 260 mV, respectively, for the CoII/CoI and CoIII-H/CoII-H couples from [Co(DPA-1-MPI)(H2O)](PF6)3 to [Co(DPA-3-MPI)(H2O)](PF6)3, with the former being ~32 times as active as the latter in photocatalytic H2 production.	Hydrogen	123-125	mannose phosphate isomerase	Homo sapiens	148-151
29993059-5	2018	Therefore, the name "coinage-metal" bond is suggested for the non-covalent interaction in BMX, by analogy with hydrogen and halogen bonds.	Hydrogen	111-119	BMX non-receptor tyrosine kinase	Homo sapiens	90-93
29753788-2	2018	During a gas-phase HDX-MS experiment, heteroatom-bound non-amide hydrogens are made to exchange with deuterium during a millisecond timespan after electrospray ionization (ESI) by reaction with the highly basic reagent ND3, enabling conformational analysis of protein states that are pertinent to the native solution-phase.	Hydrogen	65-74	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	219-222
29969126-0	2018	Expression of concern: Synthesis of octahedral, truncated octahedral, and cubic Rh2Ni nanocrystals and their structure-activity relationship for the decomposition of hydrazine in aqueous solution to hydrogen.	Hydrogen	199-207	Rh associated glycoprotein	Homo sapiens	80-83
29969126-1	2018	Expression of concern for "Synthesis of octahedral, truncated octahedral, and cubic Rh2Ni nanocrystals and their structure-activity relationship for the decomposition of hydrazine in aqueous solution to hydrogen" by Chun Li et al., Nanoscale, 2016, 8, 7043-7055.	Hydrogen	203-211	Rh associated glycoprotein	Homo sapiens	84-87
30011796-1	2018	In this work, SBA-15 silica and silica-titania have been used as supports for photocatalysts based on AuCu alloy (Au:Cu = 1) to be used in the preferential oxidation of CO (CO-PROX) in excess of hydrogen at room temperature and atmospheric pressure both in the dark and under simulated solar light irradiation.	Hydrogen	195-203	pyruvate dehydrogenase complex component X	Homo sapiens	176-180
30310606-4	2018	(Photo)electrochemical measurements allowed characterization of electron transfer processes within such an assembly and to demonstrate for the first time that a CoI species is formed as the entry into the light-driven H2 evolution mechanism of a dye-sensitized photocathode.	Hydrogen	218-220	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	161-164
29774606-0	2018	Nitrogen-Doped CoP Electrocatalysts for Coupled Hydrogen Evolution and Sulfur Generation with Low Energy Consumption.	Hydrogen	48-56	caspase recruitment domain family member 16	Homo sapiens	15-18
29774606-3	2018	This study proposes an N-doped CoP as the novel and effective electrocatalyst for hydrogen evolution reaction (HER) and constructs a coupled system for simultaneous hydrogen and sulfur production.	Hydrogen	82-90	caspase recruitment domain family member 16	Homo sapiens	31-34
29774606-3	2018	This study proposes an N-doped CoP as the novel and effective electrocatalyst for hydrogen evolution reaction (HER) and constructs a coupled system for simultaneous hydrogen and sulfur production.	Hydrogen	165-173	caspase recruitment domain family member 16	Homo sapiens	31-34
29803450-12	2018	Docking simulation showed their strong hydrophobic interaction with BChE, stabilized by hydrogen bonds and pi-pi interactions.	Hydrogen	88-96	butyrylcholinesterase	Homo sapiens	68-72
29971548-0	2018	Theoretical models to predict the inhibitory effect of ligands of sphingosine kinase 1 using QTAIM calculations and hydrogen bond dynamic propensity analysis.	Hydrogen	116-124	sphingosine kinase 1	Homo sapiens	66-86
29988358-8	2018	Treatment of compound-1H could arrest cell cycle in S phase through up-regulating P21 and P53, and down-regulating cyclin A and E in a dose-dependent manner.	Hydrogen	22-24	H3 histone pseudogene 16	Homo sapiens	82-85
29988358-9	2018	Compound-1H also induced mitochondrial-dependent apoptosis by increasing Bax, cleaved caspase-3, cleaved caspase-9 and poly ADP-ribose polymerase expression, and decreasing Bcl-2 expression.	Hydrogen	9-11	caspase 9	Homo sapiens	105-114
29426427-6	2018	Molecular docking showed that APP interacts with ACE via hydrogen bonds, electrostatic and van der Waals interactions.	Hydrogen	57-65	angiotensin I converting enzyme	Gallus gallus	49-52
29771489-0	2018	Three-Dimensional CdS/Au Butterfly Wing Scales with Hierarchical Rib Structures for Plasmon-Enhanced Photocatalytic Hydrogen Production.	Hydrogen	116-124	CDP-diacylglycerol synthase 1	Homo sapiens	18-21
29771489-5	2018	The 3D CdS/Au butterfly wing scales exhibit a high H2 production rate (221.8 mumol h-1 within 420-780 nm), showing a 241-fold increase over the CdS butterfly wing scales.	Hydrogen	51-53	CDP-diacylglycerol synthase 1	Homo sapiens	7-10
29771489-5	2018	The 3D CdS/Au butterfly wing scales exhibit a high H2 production rate (221.8 mumol h-1 within 420-780 nm), showing a 241-fold increase over the CdS butterfly wing scales.	Hydrogen	51-53	CDP-diacylglycerol synthase 1	Homo sapiens	144-147
29782802-4	2018	During the hydrogenation of 3-nitrostyrene, the TOF numbers based on surface Pt atoms of Pt1/Ni nanocrystals reached ~1800 h-1 under 3 atm of H2 at 40  C, much higher than that of Pt single atoms supported on active carbon, TiO2, SiO2, and ZSM-5.	Hydrogen	142-144	zinc finger protein 77	Homo sapiens	89-92
29782802-5	2018	Mechanistic studies reveal that the remarkable activity of Pt1/Ni nanocrystals derived from sufficient hydrogen supply because of spontaneous dissociation of H2 on both Pt and Ni atoms as well as facile diffusion of H atoms on Pt1/Ni nanocrystals.	Hydrogen	103-111	zinc finger protein 77	Homo sapiens	59-62
29782802-5	2018	Mechanistic studies reveal that the remarkable activity of Pt1/Ni nanocrystals derived from sufficient hydrogen supply because of spontaneous dissociation of H2 on both Pt and Ni atoms as well as facile diffusion of H atoms on Pt1/Ni nanocrystals.	Hydrogen	103-111	zinc finger protein 77	Homo sapiens	227-230
29782802-5	2018	Mechanistic studies reveal that the remarkable activity of Pt1/Ni nanocrystals derived from sufficient hydrogen supply because of spontaneous dissociation of H2 on both Pt and Ni atoms as well as facile diffusion of H atoms on Pt1/Ni nanocrystals.	Hydrogen	158-160	zinc finger protein 77	Homo sapiens	59-62
29677600-3	2018	Molecular docking calculations using AutoDock Vina software shows that PBTAs are proportionally oriented in the pocket of CYP1A1, establishing pi-pi stacking attractive interactions between the triazole group and the Phe224, as well as, the hydrogen bonds of the terminal NH2 over the benzotriazole units with the Asn255 and Ser116 amino acids.	Hydrogen	241-249	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	122-128
29723807-9	2018	The binding mode analysis showed that Asn47 of CBX2 formed a hydrogen bond with the OH group of C-terminal cap of UNC3866, inducing the conformational changes of diethyllysine of UNC3866 that is obviously different from that in CBX7.	Hydrogen	61-69	chromobox 7	Homo sapiens	228-232
29710432-5	2018	Extensive molecular dynamics simulations revealed that the Gly259Arg mutation stabilizes helix Q through a newly formed hydrogen bonding network, which places the cofactor in a much more favorable geometry in UGT1A5*8 as compared to the wild-type.	Hydrogen	120-128	UDP glucuronosyltransferase family 1 member A5	Homo sapiens	209-215
29855720-2	2018	The intermolecular hydrogen bonding interaction energies have been calculated using the B3LYP/6-311++G**, B3LYP/6-311++G(2df,2p), MP2(full)/6-311++G** and MP2(full)/6-311++G(2df,2p) methods, respectively.	Hydrogen	19-27	tryptase pseudogene 1	Homo sapiens	130-133
29855720-2	2018	The intermolecular hydrogen bonding interaction energies have been calculated using the B3LYP/6-311++G**, B3LYP/6-311++G(2df,2p), MP2(full)/6-311++G** and MP2(full)/6-311++G(2df,2p) methods, respectively.	Hydrogen	19-27	tryptase pseudogene 1	Homo sapiens	155-158
29738258-9	2018	Importantly, (kappa4-Ph2PPrPDI)Mn(mu-eta1,eta2-CO)K(18-crown-6) was found to react instantaneously with either HBF4 OEt2 or HOTf to evolve H2 and generate the corresponding Mn(I) complex, [(Ph2PPrPDI)Mn(CO)][BF4] or [(Ph2PPrPDI)Mn(CO)][OTf], respectively.	Hydrogen	139-141	secreted phosphoprotein 1	Homo sapiens	37-41
29728565-4	2018	The nanosweeper recognize and bind Abeta via co-assembly through hydrogen bonding interactions.	Hydrogen	65-73	amyloid beta (A4) precursor protein	Mus musculus	35-40
29442845-1	2018	Special emphasis was given to evaluate the influence of calcination parameters in the structural and textural properties of the catalysts and the final impact in the catalytic activity of CO oxidation reaction under hydrogen rich atmosphere (PROX-CO).	Hydrogen	216-224	pyruvate dehydrogenase complex component X	Homo sapiens	242-246
29632183-7	2018	Structural models show that OR5AN1, highly responsive to nitromusks over macrocyclic musks, stabilizes odorants by hydrogen bonding to Tyr260 of transmembrane alpha-helix 6 and hydrophobic interactions with surrounding aromatic residues Phe105, Phe194, and Phe207.	Hydrogen	115-123	olfactory receptor family 5 subfamily AN member 1	Homo sapiens	28-34
29671827-7	2018	CoMFA/CoMSIA contour maps demonstrated that bulky substitutions and hydrogen-bond donors were preferred at R1 and 1-position, respectively, and introducing hydrophilic substitutions at R1 and R4 was important for improving BTK inhibitory activities.	Hydrogen	68-76	CD1b molecule	Homo sapiens	107-115
29543459-8	2018	MTP here acts as a HBA and contributes to the hydrogen bonding with quinoline, which results in higher experimental selectivity values.	Hydrogen	46-54	metallothionein 1B	Homo sapiens	0-3
29393999-5	2018	Ru-MDB exhibits red emission, a large Stokes shift, high specificity and sensitivity for H2 S detection, and low cytotoxicity, which enables imaging and flow cytometry analysis of lysosomal H2 S generation in live inflamed cells under drug stimulation.	Hydrogen	89-91	ABR activator of RhoGEF and GTPase	Homo sapiens	3-6
29349619-5	2018	Here, we present the 1H, 15N, and 13C chemical shift assignments of the DPC micelle immersed FATC domains of the human PIKKs ataxia-telangiectasia mutated (ATM, residues 3024-3056) and DNA protein kinase catalytic subunit (DNA-PKcs, residues 4096-4128), both fused to the 56 residue long B1 domain of Streptococcal protein G (GB1).	Hydrogen	21-23	ATM serine/threonine kinase	Homo sapiens	156-159
29445910-0	2018	1H, 13C and 15N resonance assignment of domain 1 of trans-activation response element (TAR) RNA binding protein isoform 1 (TRBP2) and its comparison with that of isoform 2 (TRBP1).	Hydrogen	0-2	TARBP2 subunit of RISC loading complex	Homo sapiens	123-128
29445910-5	2018	Here, we report 1H, 13C and 15N resonance assignment for dsRBD1 of TRBP2 (1-105) containing the additional N-terminal residues.	Hydrogen	16-18	TARBP2 subunit of RISC loading complex	Homo sapiens	67-72
28503736-3	2018	The study was to investigate whether and how H2 S improved myocardial hypertrophy via a SIRT3-dependent manner.	Hydrogen	45-47	sirtuin 3	Mus musculus	88-93
29533013-3	2018	By tuning the catalytic solvents and catalyst supports, the efficiency of direct H2 oxidation to H2 O2 can be optimized well with the hollow Pd2 Sn NPs/P25 exhibiting H2 O2 selectivity up to 80.7% and productivity of 60.8 mol kgcat-1 h-1 .	Hydrogen	81-83	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	141-144
29261513-0	2018	High-content hydrogen water-induced downregulation of miR-136 alleviates non-alcoholic fatty liver disease by regulating Nrf2 via targeting MEG3.	Hydrogen	13-21	microRNA 136	Mus musculus	54-61
29261513-0	2018	High-content hydrogen water-induced downregulation of miR-136 alleviates non-alcoholic fatty liver disease by regulating Nrf2 via targeting MEG3.	Hydrogen	13-21	maternally expressed 3	Mus musculus	140-144
29517905-2	2018	The design of isoform-specific activators is thus of great biomedical importance and requires detailed structural information about PKG isoforms bound with activators, including accurate positions of hydrogen atoms and a description of the hydrogen bonding and water architecture.	Hydrogen	200-208	protein kinase cGMP-dependent 1	Homo sapiens	132-135
29517905-2	2018	The design of isoform-specific activators is thus of great biomedical importance and requires detailed structural information about PKG isoforms bound with activators, including accurate positions of hydrogen atoms and a description of the hydrogen bonding and water architecture.	Hydrogen	240-248	protein kinase cGMP-dependent 1	Homo sapiens	132-135
29517905-5	2018	Comparative analysis of the backbone hydrogen/deuterium exchange patterns in PKG II:8-pCPT-cGMP and previously reported PKG Ibeta:cGMP XN structures suggests that the ability of these agonists to activate PKG is related to how effectively they quench dynamics of the cyclic nucleotide binding pocket and the surrounding regions.	Hydrogen	37-45	protein kinase cGMP-dependent 1	Homo sapiens	77-80
29517905-5	2018	Comparative analysis of the backbone hydrogen/deuterium exchange patterns in PKG II:8-pCPT-cGMP and previously reported PKG Ibeta:cGMP XN structures suggests that the ability of these agonists to activate PKG is related to how effectively they quench dynamics of the cyclic nucleotide binding pocket and the surrounding regions.	Hydrogen	37-45	protein kinase cGMP-dependent 1	Homo sapiens	120-123
29517905-5	2018	Comparative analysis of the backbone hydrogen/deuterium exchange patterns in PKG II:8-pCPT-cGMP and previously reported PKG Ibeta:cGMP XN structures suggests that the ability of these agonists to activate PKG is related to how effectively they quench dynamics of the cyclic nucleotide binding pocket and the surrounding regions.	Hydrogen	37-45	protein kinase cGMP-dependent 1	Homo sapiens	120-123
29507247-6	2018	29beta-NAc binds tightly to FmlH by engaging the residues Y46 through edge-to-face pi-stacking with its A-phenyl ring, R142 in a salt-bridge interaction with its carboxylate group, and K132 through water-mediated hydrogen bonding with its N-acetyl group.	Hydrogen	213-221	basic transcription factor 3	Homo sapiens	2-10
29554910-8	2018	The binding between KTN and porcine gastric mucin (PGM) is dominated by electrostatic attractions and hydrogen bondings at pH 4.5, and disulfide bonds also plays a key role in the interaction at pH 7.4.	Hydrogen	102-110	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	36-49
29309709-6	2018	We identified a 5"-GNGACCC-3" consensus motif in the RNA and S97N mutation in complimentarity determining region L3 of the Fab that independently impart about an order of magnitude improvement in affinity, resulting from new hydrogen bonding interactions.	Hydrogen	225-233	FA complementation group B	Homo sapiens	123-126
29438888-8	2018	Compound 3o was nicely bound to BuChE via three hydrogen bonds, one Alkyl interaction and three Pi-Alkyl interactions.	Hydrogen	48-56	butyrylcholinesterase	Homo sapiens	32-37
29024569-6	2018	The interaction of proline-rich chaperones with BChE subunits (B-P) provides a conduit to facilitate the interactions between BChE subunits (B-B) of the complex, which is mainly attributed to hydrophobic interactions and hydrogen-bond binding.	Hydrogen	221-229	cholinesterase	Cricetulus griseus	48-52
29024569-6	2018	The interaction of proline-rich chaperones with BChE subunits (B-P) provides a conduit to facilitate the interactions between BChE subunits (B-B) of the complex, which is mainly attributed to hydrophobic interactions and hydrogen-bond binding.	Hydrogen	221-229	cholinesterase	Cricetulus griseus	126-130
29264659-3	2018	Grx5 has a well-defined glutathione-binding pocket with protein amino acid residues providing many ionic and hydrogen binding contacts to the bound glutathione.	Hydrogen	109-117	glutaredoxin 5	Homo sapiens	0-4
29430823-6	2018	With this unique molecular structure, the optimized UCN-BD sample exhibits a superior performance for photocatalytic hydrogen evolution upon visible light illumination (3428 micromol h-1 g-1 ), which is nearly six times of that of the pristine g-C3 N4 .	Hydrogen	117-125	urocortin	Homo sapiens	52-55
29785179-5	2018	Molecular dynamics simulations suggest that binding between BDNF and PEG-PLE is mediated through electrostatic coupling as well as transient hydrogen bonding.	Hydrogen	141-149	brain derived neurotrophic factor	Mus musculus	60-64
29359939-2	2018	Here, we report the formation of the catechol-fused bis(methylthio)tetrathiafulvalene (H2Cat-BMT-TTF) adlayer hydrogen bonding with an imidazole-terminated alkanethiolate self-assembled monolayer (Im-SAM) on Au(111).	Hydrogen	110-118	ras homolog family member H	Homo sapiens	97-100
29359939-6	2018	On the vibrational spectrum measured by IRAS, the strong hydrogen bonds between H2Cat-BMT-TTF and Im-SAM are characterized by the remarkably red-shifted OH stretching mode at 3140 cm-1, which is much lower than that for hydrogen-bonding water (typically ~3300 cm-1).	Hydrogen	57-65	ras homolog family member H	Homo sapiens	90-93
29359939-6	2018	On the vibrational spectrum measured by IRAS, the strong hydrogen bonds between H2Cat-BMT-TTF and Im-SAM are characterized by the remarkably red-shifted OH stretching mode at 3140 cm-1, which is much lower than that for hydrogen-bonding water (typically ~3300 cm-1).	Hydrogen	220-228	ras homolog family member H	Homo sapiens	90-93
29359939-7	2018	The OH stretching mode frequency and the adsorption strength for the H2Cat-BMT-TTF molecule hydrogen bonding with imidazole groups are quantitatively examined on the basis of DFT calculations.	Hydrogen	92-100	ras homolog family member H	Homo sapiens	79-82
29430581-12	2018	Docking simulation of plagioneurin B with CD95 demonstrated that the high binding affinity and hydrogen bonds formation may explain the capability of plagioneurin B to trigger apoptosis.	Hydrogen	95-103	Fas cell surface death receptor	Homo sapiens	42-46
29507636-1	2018	A family of novel chloramphenicol base-amide organocatalysts possessing a NH functionality at C-1 position as monodentate hydrogen bond donor were developed and evaluated for enantioselective organocatalytic alcoholysis of meso-cyclic anhydrides.	Hydrogen	122-130	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	94-97
29292995-3	2018	Additionally, CCl4 is transparent in the hydrogen-bonded region; CCl4 thus constitutes an excellent ambient thermal energy matrix isolation medium for diagnosing interactions with water.	Hydrogen	41-49	C-C motif chemokine ligand 4	Homo sapiens	14-18
29292995-3	2018	Additionally, CCl4 is transparent in the hydrogen-bonded region; CCl4 thus constitutes an excellent ambient thermal energy matrix isolation medium for diagnosing interactions with water.	Hydrogen	41-49	C-C motif chemokine ligand 4	Homo sapiens	65-69
29303245-0	2018	High Yield Exfoliation of WS2 Crystals into 1-2 Layer Semiconducting Nanosheets and Efficient Photocatalytic Hydrogen Evolution from WS2/CdS Nanorod Composites.	Hydrogen	109-117	CDP-diacylglycerol synthase 1	Homo sapiens	137-140
29303245-3	2018	The exfoliated WS2 nanosheeets are n-type, have a bandgap of ~1.78 eV, and act as a cocatalyst with CdS nanorods in photocatalytic hydrogen evolution using lactate as a sacrificial electron donor.	Hydrogen	131-139	CDP-diacylglycerol synthase 1	Homo sapiens	100-103
29303245-4	2018	Up to a 26-fold increase in H2 evolution rate was observed with WS2/CdS hybrids compared with their pure CdS counterpart, and an absorbed photon quantum yield (AQE) of &gt;60% was measured with the optimized photocatalyst.	Hydrogen	28-30	CDP-diacylglycerol synthase 1	Homo sapiens	68-71
29299563-0	2018	Ni3S2@MoO3 core/shell arrays on Ni foam modified with ultrathin CdS layer as a superior electrocatalyst for hydrogen evolution reaction.	Hydrogen	108-116	CDP-diacylglycerol synthase 1	Homo sapiens	64-67
29299563-1	2018	An ultrathin CdS layer-modified MoO3/Ni3S2 hierarchical nanoarray on Ni foam exhibits ultrahigh electrocatalytic activity towards the hydrogen evolution reaction with a small overpotential of 30 mV at -10 mA cm-2 due to the synergistic effect of easy electron transfer among CdS, MoO3 and Ni3S2/NF and the well-designed structure, which outperforms the current non-noble electrocatalysts.	Hydrogen	134-142	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
29299563-1	2018	An ultrathin CdS layer-modified MoO3/Ni3S2 hierarchical nanoarray on Ni foam exhibits ultrahigh electrocatalytic activity towards the hydrogen evolution reaction with a small overpotential of 30 mV at -10 mA cm-2 due to the synergistic effect of easy electron transfer among CdS, MoO3 and Ni3S2/NF and the well-designed structure, which outperforms the current non-noble electrocatalysts.	Hydrogen	134-142	CDP-diacylglycerol synthase 1	Homo sapiens	275-278
29564982-11	2018	The molecular docking analysis of compound m45 with the N-terminal domain binding site of the HSP90 show hydroxyl group on phenyl ring is necessary to form hydrogen bonding with hydrophilic residues in binding site and a conserved water molecule.	Hydrogen	156-164	heat shock protein 90 alpha family class A member 1	Homo sapiens	94-99
30422758-1	2018	Azo linked salicyldehyde and a new 2-hydroxy acetophenone based ligands (HL1 and HL2) with their copper(II) complexes [Cu(L1)2] (1) and [Cu(L2)2] (2) were synthesized and characterized by spectroscopic methods such as 1H, 13C NMR, UV-Vis spectroscopy and elemental analyses.	Hydrogen	218-220	intelectin 1	Homo sapiens	73-76
29291994-7	2018	Finally, our results indicated that the active sites (His39 in 3CLSP and His41 in 3CL protease) were conservative, and contacted compounds 2 and 3 via hydrogen bonds and hydrophobic forces in the putative substrate-binding models.	Hydrogen	151-159	calmodulin like 5	Homo sapiens	64-68
28932831-0	2017	Smart supramolecular sensing with cucurbit[n]urils: probing hydrogen bonding with SERS.	Hydrogen	60-68	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	82-86
28932831-3	2017	We demonstrate strong interaction effects in the SERS peaks, which we demonstrate are likely from the hydrogen bonding of water complexes in the vicinity of the CB[n]s.	Hydrogen	102-110	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	49-53
28597227-5	2017	The Val cleavage by fluorescein isothiocyanate-mediated Edman degradation yielded 3-fluorescein-1-(furan-2-ylmethyl)-5-(propan-2-yl)-2-thioxoimidazolidin-4-one (FFA-Val-FTH), which was characterized by 1H and 13C NMR spectroscopy.	Hydrogen	202-204	ferritin heavy chain 1	Homo sapiens	169-172
28843351-4	2017	2D 13C-1H methyl NMR indicates that with increasing concentration of polysorbates, the Fab region showed a decrease in crosspeak volumes.	Hydrogen	7-9	FA complementation group B	Homo sapiens	87-90
28715878-5	2017	CdS nanoparticles (11 wt.%) were uniformly deposited on the surface of La-doped halloysite nanotube (La-HNT) with the average size of 5 nm, and the notable photocatalytic hydrogen evolution rate of CdS/La-HNT reached up to 47.5 mumol/h.	Hydrogen	171-179	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
28944928-11	2017	Furthermore, hydrogen improved the deteriorated hypertrophic responses and inhibited the enhanced autophagic activity mediated by ISO administration in vivo, as indicated by decreasing HW and HW/BW, and suppressing the protein expression levels of Beclin1, Atg7 and LC3B II.	Hydrogen	13-21	beclin 1, autophagy related	Mus musculus	248-255
29176605-7	2017	Computational analysis depicted the influential role of CuO nanoparticles on zebrafish embryo"s he1a, sod1 and p53 functional expression through hydrophobic and hydrogen bond interaction with amino acid residues.	Hydrogen	161-169	tumor protein p53	Danio rerio	111-114
29373864-0	2017	Sulfur denitrosylation by an engineered Trx-like DsbG enzyme identifies nucleophilic cysteine hydrogen bonds as key functional determinant.	Hydrogen	94-102	thioredoxin	Homo sapiens	40-43
28940424-12	2017	In addition, homology modelling and molecular dynamic simulation of N1366S and wild-type NaV1.4 channels indicated that the arginine-to-serine substitution disrupted the hydrogen bond formed between N1366 and R1454.	Hydrogen	170-178	sodium voltage-gated channel alpha subunit 4	Homo sapiens	89-95
28959811-2	2017	All the Hex A-inhibiting iminosugars tested formed hydrogen bonds with Arg178, Asp322, Tyr421 and Glu462 and had the favorable cation-pi interaction with Trp460.	Hydrogen	51-59	hexosaminidase subunit alpha	Homo sapiens	8-13
29020768-0	2017	Visible-Light-Driven Valorization of Biomass Intermediates Integrated with H2 Production Catalyzed by Ultrathin Ni/CdS Nanosheets.	Hydrogen	75-77	CDP-diacylglycerol synthase 1	Homo sapiens	115-118
29057400-0	2017	A Cu3P-CoP hybrid nanowire array: a superior electrocatalyst for acidic hydrogen evolution reactions.	Hydrogen	72-80	caspase recruitment domain family member 16	Homo sapiens	7-10
28988626-7	2017	40b showed more potent ex vivo efficacy than 1, with rat plasma VAP-1 inhibitory activity of 92% at 1h after oral administration at 0.3mg/kg.	Hydrogen	100-102	amine oxidase, copper containing 3	Rattus norvegicus	64-69
28901420-8	2017	In addition, the R725Q (rs17482078) SNP, which was an additional potentially damaging substitution, was suggested to decrease the enzymatic activity of ERAP1, as this substitution may lead to the loss of two hydrogen bonds between R725 and D766 and affect the stability of the C-terminus of ERAP1.	Hydrogen	208-216	endoplasmic reticulum aminopeptidase 1	Homo sapiens	152-157
28901420-8	2017	In addition, the R725Q (rs17482078) SNP, which was an additional potentially damaging substitution, was suggested to decrease the enzymatic activity of ERAP1, as this substitution may lead to the loss of two hydrogen bonds between R725 and D766 and affect the stability of the C-terminus of ERAP1.	Hydrogen	208-216	endoplasmic reticulum aminopeptidase 1	Homo sapiens	291-296
26520520-6	2015	The (CH2)3 MCl complexes have similar angular geometries to those of the hydrogen- and halogen-bonded analogues (CH2)3 HCl and (CH2)3 ClF, respectively.	Hydrogen	73-81	C-type lectin domain family 4 member D	Homo sapiens	11-14
26493883-0	2015	Heterolysis of H2 Across a Classical Lewis Pair, 2,6-Lutidine BCl3 : Synthesis, Characterization, and Mechanism.	Hydrogen	15-17	BCL3 transcription coactivator	Homo sapiens	62-66
26493883-1	2015	We report that 2,6-lutidine trichloroborane (Lut BCl3 ) reacts with H2 in toluene, bromobenzene, dichloromethane, and Lut solvents producing the neutral hydride, Lut BHCl2 .	Hydrogen	68-70	BCL3 transcription coactivator	Homo sapiens	49-53
26493883-3	2015	Lut BCl3 was calculated to react with H2 and form the ion pair, [LutH(+) ][HBCl3 (-) ], with a barrier of DeltaH( ) =24.7 kcal mol(-1) (DeltaG( ) =29.8 kcal mol(-1) ).	Hydrogen	38-40	BCL3 transcription coactivator	Homo sapiens	4-8
26495970-6	2015	HS produced glomerular hypertrophy and decreased ACE2 and nephrin expressions, loss of morphological integrity of the podocyte processes, and increased proteinuria, characterized by loss of albumin and high molecular weight proteins.	Hydrogen	0-2	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	58-65
26493912-0	2015	Hydrogen-bond vibrational and energetic dynamical properties in sI and sII clathrate hydrates and in ice Ih: Molecular dynamics insights.	Hydrogen	0-8	transcription elongation factor A1	Homo sapiens	71-74
26493912-7	2015	Further, modes for vibration and energy-transfer via hydrogen bonds in sI hydrate were found to occur at higher frequencies vis-a-vis ice Ih and sII hydrate in both the water-librational and OH H regions because of the more strained nature of hydrogen bonds therein.	Hydrogen	53-61	transcription elongation factor A1	Homo sapiens	145-148
26493912-7	2015	Further, modes for vibration and energy-transfer via hydrogen bonds in sI hydrate were found to occur at higher frequencies vis-a-vis ice Ih and sII hydrate in both the water-librational and OH H regions because of the more strained nature of hydrogen bonds therein.	Hydrogen	243-251	transcription elongation factor A1	Homo sapiens	145-148
26406159-6	2015	Further reduction and protonation at the Rh2 core for all three complexes rapidly catalyzes H2 formation with varied calculated turnover frequencies (TOF) and overpotential values (eta): 2.6 x 10(4) s(-1) and 0.56 V for Rh2-dppn, 2.8 x 10(4) s(-1) and 0.50 V for Rh2-dppz2, and 5.9 x 10(4) s(-1) and 0.64 V for Rh2-phen2.	Hydrogen	92-94	Rh associated glycoprotein	Homo sapiens	41-44
26406159-6	2015	Further reduction and protonation at the Rh2 core for all three complexes rapidly catalyzes H2 formation with varied calculated turnover frequencies (TOF) and overpotential values (eta): 2.6 x 10(4) s(-1) and 0.56 V for Rh2-dppn, 2.8 x 10(4) s(-1) and 0.50 V for Rh2-dppz2, and 5.9 x 10(4) s(-1) and 0.64 V for Rh2-phen2.	Hydrogen	92-94	Rh associated glycoprotein	Homo sapiens	220-223
26406159-6	2015	Further reduction and protonation at the Rh2 core for all three complexes rapidly catalyzes H2 formation with varied calculated turnover frequencies (TOF) and overpotential values (eta): 2.6 x 10(4) s(-1) and 0.56 V for Rh2-dppn, 2.8 x 10(4) s(-1) and 0.50 V for Rh2-dppz2, and 5.9 x 10(4) s(-1) and 0.64 V for Rh2-phen2.	Hydrogen	92-94	Rh associated glycoprotein	Homo sapiens	220-223
26406159-6	2015	Further reduction and protonation at the Rh2 core for all three complexes rapidly catalyzes H2 formation with varied calculated turnover frequencies (TOF) and overpotential values (eta): 2.6 x 10(4) s(-1) and 0.56 V for Rh2-dppn, 2.8 x 10(4) s(-1) and 0.50 V for Rh2-dppz2, and 5.9 x 10(4) s(-1) and 0.64 V for Rh2-phen2.	Hydrogen	92-94	Rh associated glycoprotein	Homo sapiens	220-223
26406159-8	2015	The cis-[Rh2(II,II)(mu-DTolF)2(NN)2](2+) architecture benefits by combining electron-rich formamidinate bridges, a redox-active Rh2(II,II) core, and electron-accepting NN diimine ligands to allow for the electrocatalysis of H(+) substrate to H2 fuel.	Hydrogen	242-244	Rh blood group D antigen	Homo sapiens	9-18
26406159-8	2015	The cis-[Rh2(II,II)(mu-DTolF)2(NN)2](2+) architecture benefits by combining electron-rich formamidinate bridges, a redox-active Rh2(II,II) core, and electron-accepting NN diimine ligands to allow for the electrocatalysis of H(+) substrate to H2 fuel.	Hydrogen	242-244	Rh associated glycoprotein	Homo sapiens	9-12
26309119-0	2015	Investigation on graphene and Pt co-modified CdS nanowires with enhanced photocatalytic hydrogen evolution activity under visible light irradiation.	Hydrogen	88-96	CDP-diacylglycerol synthase 1	Homo sapiens	45-48
26309119-5	2015	The graphene and Pt comodified CdS nanowires gain a high hydrogen evolution rate of 3984 mumol h(-1) g(-1), which is almost 4 times higher than that of bare CdS nanowires and also higher than the sum of graphene-CdS and Pt-CdS nanowires.	Hydrogen	57-65	CDP-diacylglycerol synthase 1	Homo sapiens	31-34
26269596-0	2015	Biased Gs versus Gq proteins and beta-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network.	Hydrogen	117-125	tachykinin receptor 1	Homo sapiens	64-76
26431526-11	2015	Finally, recruitment of immuno-reactive GLUT12 to the muscle plasma membrane was increased following 1h of intraperitoneal insulin administration (compared to a control fasted state).	Hydrogen	101-103	solute carrier family 2 member 12	Homo sapiens	40-46
26594418-0	2015	Double salt crystal structure of hexa-sodium hemiundeca-hydrogen alpha-hexa-molybdoplatinate(IV) heminona-hydrogen alpha-hexa-molybdoplatinate(IV) nona-cosa-hydrate: di-hydrogen disordered-mixture double salt.	Hydrogen	166-177	hexosaminidase subunit alpha	Homo sapiens	33-37
26594418-0	2015	Double salt crystal structure of hexa-sodium hemiundeca-hydrogen alpha-hexa-molybdoplatinate(IV) heminona-hydrogen alpha-hexa-molybdoplatinate(IV) nona-cosa-hydrate: di-hydrogen disordered-mixture double salt.	Hydrogen	166-177	hexosaminidase subunit alpha	Homo sapiens	71-75
26594418-0	2015	Double salt crystal structure of hexa-sodium hemiundeca-hydrogen alpha-hexa-molybdoplatinate(IV) heminona-hydrogen alpha-hexa-molybdoplatinate(IV) nona-cosa-hydrate: di-hydrogen disordered-mixture double salt.	Hydrogen	166-177	hexosaminidase subunit alpha	Homo sapiens	71-75
26136433-0	2015	Enhanced Hydrogen Production from DNA-Assembled Z-Scheme TiO2-CdS Photocatalyst Systems.	Hydrogen	9-17	CDP-diacylglycerol synthase 1	Homo sapiens	62-65
26136433-6	2015	The inclusion of benzoquinone (BQ) equidistant between the TiO2 and CdS through DNA assembly further increased H2 production.	Hydrogen	111-113	CDP-diacylglycerol synthase 1	Homo sapiens	68-71
26722753-2	2015	We compare the photocatalytic activity for hydrogen production of core-shell structures of Au@Pd and Au@(Au/Pd alloy) on seeded rods of CdSe@CdS and show that Au@alloy was superior toward hydrogen production.	Hydrogen	43-51	CDP-diacylglycerol synthase 1	Homo sapiens	136-139
26722753-2	2015	We compare the photocatalytic activity for hydrogen production of core-shell structures of Au@Pd and Au@(Au/Pd alloy) on seeded rods of CdSe@CdS and show that Au@alloy was superior toward hydrogen production.	Hydrogen	188-196	CDP-diacylglycerol synthase 1	Homo sapiens	136-139
26142902-5	2015	The 3D structure of rLap1 showed it had a conserved functional charge/dipole complex and a hydrogen bond network of Zn2-D179-S228-Q177-D229-S158 around its active center.	Hydrogen	91-99	alanyl aminopeptidase, membrane	Rattus norvegicus	20-25
26087061-5	2015	Amino acid, Lys108 plays a key role in aromatase activity through the formation of a salt bridge with Asp147 and two hydrogen bonds with Asp147 and Gln150 in mCPR.	Hydrogen	117-125	cytochrome p450 oxidoreductase	Mus musculus	158-162
26146957-0	2015	2D-GaS as a Photocatalyst for Water Splitting to Produce H2.	Hydrogen	57-59	gastrin	Homo sapiens	3-6
26146957-1	2015	Using first-principles local and hybrid density functional theoretical calculations, a thickness-dependent electronic structure of layered GaS is determined, and it is shown that 2D GaS has an electronic structure with valence and conduction bands that straddle the redox potentials of hydrogen evolution reaction and oxygen evolution reaction up to a critical thickness (&lt;5.5 nm).	Hydrogen	286-294	gastrin	Homo sapiens	182-185
26146957-4	2015	Experiments that verify some of the predictions in this study are presented, and it is shown that GaS is effective in absorption of light and evolution of H2 (887 mumol h(-1) g(-1)) in the presence of aqueous solution of hydrazine (1% v/v).	Hydrogen	155-157	gastrin	Homo sapiens	98-101
26146957-5	2015	This study should open up the use of nanoscale GaS in conversion of solar energy into environment-friendly chemical energy in the form of hydrogen.	Hydrogen	138-146	gastrin	Homo sapiens	47-50
26196359-0	2015	Fabrication of hierarchical ZnO/CdS heterostructured nanocomposites for enhanced hydrogen evolution from solar water splitting.	Hydrogen	81-89	CDP-diacylglycerol synthase 1	Homo sapiens	32-35
26196359-4	2015	The synthesized photocatalysts under simulated solar irradiation exhibited hydrogen evolution rates of 870 and 1007 mumol h(-1) g(-1) for the ZnO rod/CdS and ZnO nanoparticle/CdS composites, respectively, compared to the native ZnO (40 mumol h(-1) g(-1) for rods and 154 mumol h(-1) g(-1) for particles) and CdS (208 mumol h(-1) g(-1)) structures.	Hydrogen	75-83	CDP-diacylglycerol synthase 1	Homo sapiens	150-153
26196359-4	2015	The synthesized photocatalysts under simulated solar irradiation exhibited hydrogen evolution rates of 870 and 1007 mumol h(-1) g(-1) for the ZnO rod/CdS and ZnO nanoparticle/CdS composites, respectively, compared to the native ZnO (40 mumol h(-1) g(-1) for rods and 154 mumol h(-1) g(-1) for particles) and CdS (208 mumol h(-1) g(-1)) structures.	Hydrogen	75-83	CDP-diacylglycerol synthase 1	Homo sapiens	175-178
26196359-4	2015	The synthesized photocatalysts under simulated solar irradiation exhibited hydrogen evolution rates of 870 and 1007 mumol h(-1) g(-1) for the ZnO rod/CdS and ZnO nanoparticle/CdS composites, respectively, compared to the native ZnO (40 mumol h(-1) g(-1) for rods and 154 mumol h(-1) g(-1) for particles) and CdS (208 mumol h(-1) g(-1)) structures.	Hydrogen	75-83	CDP-diacylglycerol synthase 1	Homo sapiens	175-178
26196359-6	2015	Our results confirmed that the morphology of the host matrix ZnO played a crucial role in forming ZnO/CdS heterostructures with improved interface for the direct Z-scheme mechanism with enhanced hydrogen evolution efficiency.	Hydrogen	195-203	CDP-diacylglycerol synthase 1	Homo sapiens	102-105
25761782-6	2015	Here we use hydrogen/deuterium exchange (HDX) mass spectrometry (MS) for probing the conformational dynamics of the model protein myoglobin (Mb) in the presence of N(2) bubbles.	Hydrogen	12-20	myoglobin	Homo sapiens	130-139
26079848-23	2015	The redox-complemented complex [Fe2(adt(Bn))(CO)3(dppv)(FcP*)](n+) catalyzes both proton reduction and hydrogen oxidation (FcP* = (C5Me5)Fe(C5Me4CH2PEt2)).	Hydrogen	103-111	HBFQTL2	Homo sapiens	56-60
26079848-23	2015	The redox-complemented complex [Fe2(adt(Bn))(CO)3(dppv)(FcP*)](n+) catalyzes both proton reduction and hydrogen oxidation (FcP* = (C5Me5)Fe(C5Me4CH2PEt2)).	Hydrogen	103-111	HBFQTL2	Homo sapiens	123-127
26173259-7	2015	In order to get insight into the antibody-p110gamma interface, hydrogen-deuterium exchange coupled to MS (HDX-MS) measurements were performed demonstrating binding of the monoclonal antibody to the C2 domain in p110gamma, which was accompanied by conformational changes in the helical domain harbouring the Gbetagamma-binding site.	Hydrogen	63-71	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	211-220
26003800-0	2015	Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway.	Hydrogen	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	91-94
26003800-0	2015	Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway.	Hydrogen	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	117-120
26003800-2	2015	This study focused on the influence of hydrogen-rich saline treatment on apoptosis pathway of ASK-1/JNK and Bcl-2/Bax radio in I/R injury of skin flaps.	Hydrogen	39-47	mitogen-activated protein kinase 8	Rattus norvegicus	100-103
26003800-2	2015	This study focused on the influence of hydrogen-rich saline treatment on apoptosis pathway of ASK-1/JNK and Bcl-2/Bax radio in I/R injury of skin flaps.	Hydrogen	39-47	BCL2 associated X, apoptosis regulator	Rattus norvegicus	114-117
26056257-6	2015	Molecular dynamics simulations and hydrogen/deuterium exchange of Hsp90-dependent Src kinase variants further reveal increased transitions between inactive and active states and exposure of specific kinase regions.	Hydrogen	35-43	heat shock protein 90 alpha family class A member 1	Homo sapiens	66-71
25965697-2	2015	By studying the kinetics of the reaction of substituted benzylbromides and chlorides with SmI2 in THF it was found that substrates para-substituted with electron-withdrawing groups (CN and CO2 Me), which are capable of forming hydrogen bonds with a proton donor and coordinating to samarium cation, react in a reversed electron apportionment mode.	Hydrogen	227-235	complement C2	Homo sapiens	189-192
25955505-3	2015	Fourier transform infrared spectra confirmed the formation of hydrogen bonds between Mb and Brij 56.	Hydrogen	62-70	myoglobin	Homo sapiens	85-87
25955505-4	2015	These hydrogen bonds acted as the electron tunnel to transfer electrons from Mb"s active sites to the underlying glassy carbon electrode.	Hydrogen	6-14	myoglobin	Homo sapiens	77-79
25812810-4	2015	The maximum values of hydrogen production and yield were 5,252.6 mL-H2 d(-1) and 3.7 mol-H2 mol(-1)(total carbohydrates), respectively.	Hydrogen	22-30	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	65-70
25907201-4	2015	Further mechanistic investigations demonstrate that the 1,7-hydrogen atom transfer is a free-radical process, whereby hydrogen migrates from C18 to C17, as evidenced by double-18- deuterium-labeled isotope experiments.	Hydrogen	60-68	cytokine like 1	Homo sapiens	148-151
25907201-4	2015	Further mechanistic investigations demonstrate that the 1,7-hydrogen atom transfer is a free-radical process, whereby hydrogen migrates from C18 to C17, as evidenced by double-18- deuterium-labeled isotope experiments.	Hydrogen	118-126	cytokine like 1	Homo sapiens	148-151
25617592-6	2015	In adult rat ventricular cardiomyocytes, exposure to HNE (10 muM for 1h) caused HNE-LKB1 adduct formation and inhibited LKB1 activity.	Hydrogen	69-71	serine/threonine kinase 11	Rattus norvegicus	84-88
25617592-6	2015	In adult rat ventricular cardiomyocytes, exposure to HNE (10 muM for 1h) caused HNE-LKB1 adduct formation and inhibited LKB1 activity.	Hydrogen	69-71	serine/threonine kinase 11	Rattus norvegicus	120-124
24961937-5	2015	RESULTS: The data indicate that 1-month treatment of N-acetylcysteine or hydrogen-rich saline significantly ameliorated systemic and splanchnic hyperdynamic circulation, corrected hepatic endothelial dysfunction, and decreased intrahepatic resistance and mesenteric angiogenesis by inhibiting inflammatory cytokines, nitric oxide, VEGF and reducing mesenteric oxidative stress in cirrhotic rats.	Hydrogen	73-81	vascular endothelial growth factor A	Rattus norvegicus	331-335
25637519-10	2015	The modelling study suggested that the D404N mutation might abolish the hydrogen bonds between residues 404 and K30 in p51 or K431 in p66, leading to impaired RT subunit structure and enhanced drug resistance.	Hydrogen	72-80	tumor protein p63	Homo sapiens	119-122
25637519-10	2015	The modelling study suggested that the D404N mutation might abolish the hydrogen bonds between residues 404 and K30 in p51 or K431 in p66, leading to impaired RT subunit structure and enhanced drug resistance.	Hydrogen	72-80	DNA polymerase delta 3, accessory subunit	Homo sapiens	134-137
25731711-10	2015	Three-dimensional structure modeling analysis found that the loss of the hydroxybenzene residue in the Y283C mutation would interrupt the hydrogen network and possibly affect the self-cleavage of the CTSK enzyme.	Hydrogen	138-146	cathepsin K	Homo sapiens	200-204
25693946-0	2015	Effects of sucrose and benzyl alcohol on GCSF conformational dynamics revealed by hydrogen deuterium exchange mass spectrometry.	Hydrogen	82-90	colony stimulating factor 3	Homo sapiens	41-45
25693946-4	2015	In this study, we examined the roles of the excipients, sucrose and benzyl alcohol, on the conformational dynamics of recombinant human granulocyte colony stimulating factor using hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS).	Hydrogen	180-188	colony stimulating factor 3	Homo sapiens	136-173
26574355-1	2015	MP2 describes hydrogen-bonded systems well, yet a higher-order electron correlation correction in the form of a CCSD(T) calculation is usually necessary to achieve benchmark quality energies.	Hydrogen	14-22	tryptase pseudogene 1	Homo sapiens	0-3
25531415-0	2015	Influence of the metal precursor on the catalytic behavior of Pt/ceria catalysts in the preferential oxidation of CO in the presence of H2 (PROX).	Hydrogen	136-138	pyruvate dehydrogenase complex component X	Homo sapiens	140-144
25730414-14	2015	The introduction of plasmonic Au probes into the Pt-CdS double-shell hollow particles facilitated the monitoring of photocatalytic hydrogen generation that occurred on an individual particle surface by single particle measurements.	Hydrogen	131-139	CDP-diacylglycerol synthase 1	Homo sapiens	52-55
25663129-0	2015	Hydrogen production on a hybrid photocatalytic system composed of ultrathin CdS nanosheets and a molecular nickel complex.	Hydrogen	0-8	CDP-diacylglycerol synthase 1	Homo sapiens	76-79
25663129-3	2015	Emission quenching and flash photolysis studies reveal that this hybrid system allows for effective electron transfer from the excited CdS nanosheets to the nickel-based complex to generate reduced intermediate species for efficient hydrogen evolution.	Hydrogen	233-241	CDP-diacylglycerol synthase 1	Homo sapiens	135-138
25679300-0	2015	HCN elimination from vinyl cyanide: product energy partitioning, the role of hydrogen-deuterium exchange reactions and a new pathway.	Hydrogen	77-85	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-3
25679300-4	2015	The KMC simulations carried out using singly deuterated VCN (CH2=CD-CN) at 148 kcal mol(-1) show the importance of hydrogen-deuterium exchange reactions: both DCN and HCN will be produced in any of the 1,1 and 1,2 elimination pathways.	Hydrogen	115-123	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	167-170
25494642-2	2015	The PDI-Co complex combines the photoactivity of the perylene dye with the electrocatalytic activity of the "Co(II)" center for photoelectrochemical hydrogen evolution reaction (HER).	Hydrogen	149-157	peptidyl arginine deiminase 1	Homo sapiens	4-7
25495481-7	2015	At 1.0 bar and 77 K, the H2 uptake of PAF-48 reaches 215 cm(3) g(-1).	Hydrogen	25-27	PCNA clamp associated factor	Homo sapiens	38-41
25011045-2	2015	HPPCO crystallized in the orthorhombic space group Pbca with an intermolecular hydrogen bonding between OH and oxygen atom of the carbonyl.	Hydrogen	79-87	PBCA	Homo sapiens	51-55
26284532-10	2015	On the other hand, we find the opposite behaviour in both cases for CGOn/STN model electrodes, reporting for the first time a higher electrocatalytic activity of CGO nanoparticles for CO/CO2 than for H2/H2O reactions in the absence of gas diffusion limitations.	Hydrogen	200-202	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	73-76
25875351-7	2015	The reconstituted mAb-C samples were then analyzed by HX-MS. Two specific sequences covering complementarity-determining regions CDR2H and CDR2L (in the variable heavy and light chains, respectively) showed significant protection against deuterium uptake (i.e., decreased hydrogen exchange).	Hydrogen	272-280	cerebellar degeneration related protein 2 like	Homo sapiens	139-144
25325956-0	2015	A rapid, nonradioactive assay for measuring heparan sulfate C-5 epimerase activity using hydrogen/deuterium exchange-mass spectrometry.	Hydrogen	89-97	glucuronic acid epimerase	Homo sapiens	44-73
26093967-2	2015	The complex formed between deprotonated LAS acid and protonated PROP molecule is stabilized by intra- and inter-molecular hydrogen bonds.	Hydrogen	122-130	lipoic acid synthetase	Homo sapiens	40-43
26093967-3	2015	The protons of the protonated amine group are hydrogen bonded to etheric and hydroxyl oxygen atoms of the LAS anion.	Hydrogen	46-54	lipoic acid synthetase	Homo sapiens	106-109
25293654-0	2014	NiP2 nanosheet arrays supported on carbon cloth: an efficient 3D hydrogen evolution cathode in both acidic and alkaline solutions.	Hydrogen	65-73	BCL2 interacting protein 2	Homo sapiens	0-4
25293654-3	2014	As a novel 3D hydrogen evolution cathode, the NiP2 NS/CC electrode is highly active in acidic solutions and needs an overpotential of 75 and 204 mV to achieve current densities of 10 and 100 mA cm(-2), respectively, and it preserves its catalytic activity for at least 57 h. Moreover, it also operates efficiently under alkaline conditions.	Hydrogen	14-22	BCL2 interacting protein 2	Homo sapiens	46-50
25203777-3	2014	One (hydrogen-bond) acceptor, one hydrophobic, and two aromatic sites (AHRR) contribute to COX-1 inhibitory activity.	Hydrogen	5-13	prostaglandin-endoperoxide synthase 1	Mus musculus	91-96
25002115-5	2014	The hydrogen storage capacity appears to be ~4.3 wt% which is close to that of some recently studied materials like ZIF and PAF.	Hydrogen	4-12	PCNA clamp associated factor	Homo sapiens	124-127
25209028-0	2014	Enhancement of solar hydrogen evolution from water by surface modification with CdS and TiO2 on porous CuInS2 photocathodes prepared by an electrodeposition-sulfurization method.	Hydrogen	21-29	CDP-diacylglycerol synthase 1	Homo sapiens	80-83
25113847-1	2014	The reduced Co(I) states of cobaloximes are powerful nucleophiles that play an important role in the hydrogen-evolving catalytic activity of these species.	Hydrogen	101-109	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	12-17
24065419-0	2014	Backbone 1H, 13C and 15N assignments of yeast Ump1, an intrinsically disordered protein that functions as a proteasome assembly chaperone.	Hydrogen	9-11	Ump1p	Saccharomyces cerevisiae S288C	46-50
24105099-0	2014	1H, 13C and 15N resonance assignments for the full-length mammalian cytochrome b5 in a membrane environment.	Hydrogen	0-2	cytochrome b5 type A	Homo sapiens	68-81
25070584-0	2014	Characterization of stress-exposed granulocyte colony stimulating factor using ELISA and hydrogen/deuterium exchange mass spectrometry.	Hydrogen	89-97	colony stimulating factor 3	Homo sapiens	35-72
25052835-3	2014	SKF-83959 [6-chloro-3-methyl-1-(m-tolyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol] is reported to be a highly biased D1 ligand, having full agonism at D1-mediated activation of phospholipase C (PLC) signaling (via GalphaQ) and antagonism at D1-mediated adenylate cyclase signaling (via GalphaOLF/S).	Hydrogen	60-62	G protein subunit alpha q	Homo sapiens	220-227
25184942-7	2014	QM/MM results with WT PRDX5 showed that hydrogen bonds in the active site are the cornerstone of two effects that make catalysis possible: the enhancement of thiolate nucleophilicity upon substrate ingress and the stabilization of the transition state.	Hydrogen	40-48	peroxiredoxin 5	Homo sapiens	22-27
25096946-0	2014	Noble-metal-free photocatalysts MoS2-graphene/CdS mixed nanoparticles/nanorods morphology with high visible light efficiency for H2 evolution.	Hydrogen	129-131	CDP-diacylglycerol synthase 1	Homo sapiens	46-49
24925626-2	2014	Highly photostable CdS(0.75)Se(0.25) alloy nanocrystals gave the highest hydrogen evolution rate (1466 mumol h(-1) g(-1)), which was about three times higher than that of CdS and seven times higher than that of CdSe.	Hydrogen	73-81	CDP-diacylglycerol synthase 1	Homo sapiens	19-22
24925626-2	2014	Highly photostable CdS(0.75)Se(0.25) alloy nanocrystals gave the highest hydrogen evolution rate (1466 mumol h(-1) g(-1)), which was about three times higher than that of CdS and seven times higher than that of CdSe.	Hydrogen	73-81	CDP-diacylglycerol synthase 1	Homo sapiens	171-174
25059734-2	2014	The addition of Ir to Pd suppresses hydride formation and leads to improved catalytic performances with respect to pure metals in the preferential oxidation of CO in H2 excess (PROX).	Hydrogen	166-168	pyruvate dehydrogenase complex component X	Homo sapiens	177-181
25139988-4	2014	Here we show by hydrogen-deuterium exchange coupled to mass spectrometry that the mutually interacting Atg1 early autophagy targeting/tethering domain and the Atg13 central domain are highly dynamic in isolation but together form a stable complex with ~ 100-nM affinity.	Hydrogen	16-24	serine/threonine protein kinase ATG1	Saccharomyces cerevisiae S288C	103-107
25139988-4	2014	Here we show by hydrogen-deuterium exchange coupled to mass spectrometry that the mutually interacting Atg1 early autophagy targeting/tethering domain and the Atg13 central domain are highly dynamic in isolation but together form a stable complex with ~ 100-nM affinity.	Hydrogen	16-24	serine/threonine protein kinase regulatory subunit ATG13	Saccharomyces cerevisiae S288C	159-164
25018099-0	2014	Three-dimensional interconnected network of nanoporous CoP nanowires as an efficient hydrogen evolution cathode.	Hydrogen	85-93	caspase recruitment domain family member 16	Homo sapiens	55-58
25018099-1	2014	For the first time we demonstrate the topotactic synthesis of a three-dimensional (3D) interconnected network of nanoporous CoP nanowires directly on a Ti substrate (np-CoP NWs/Ti) via low-temperature phosphidation of a Co2(OH)2(CO3)2/Ti precursor and its further use as a highly efficient hydrogen evolution cathode.	Hydrogen	290-298	caspase recruitment domain family member 16	Homo sapiens	124-127
25027934-6	2014	Molecular docking analysis showed that 11 was hydrogen bonded with the Arg-31 and Gln-110 residues of the IKKbeta.	Hydrogen	46-54	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	106-113
24937348-9	2014	Moreover, hydrogen-rich saline treatment dose dependently ameliorated brain injury after cardiac arrest/resuscitation, which was characterized by the increase of survival neurons in hippocampus CA1, reduction of brain edema in cortex and hippocampus, preservation of blood-brain barrier integrity, as well as the decrease of serum S100beta and neuron-specific enolase.	Hydrogen	10-18	carbonic anhydrase 1	Rattus norvegicus	194-197
24937348-9	2014	Moreover, hydrogen-rich saline treatment dose dependently ameliorated brain injury after cardiac arrest/resuscitation, which was characterized by the increase of survival neurons in hippocampus CA1, reduction of brain edema in cortex and hippocampus, preservation of blood-brain barrier integrity, as well as the decrease of serum S100beta and neuron-specific enolase.	Hydrogen	10-18	enolase 2	Rattus norvegicus	344-367
24939862-6	2014	Reaction of 2-I with the N-heterocyclic carbene IMe4 (IMe4 = 1,3,4,5-tetramethylimidazolin-2-ylidene) leads, after displacement of the iodide groups, to the unprecedented diiodide salt [Si(IMe4)2{C4(NEt2)4}](I)2 (3), containing a 1H-silole dication with a four-coordinate Si(IV) center.	Hydrogen	230-232	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	48-52
24939862-6	2014	Reaction of 2-I with the N-heterocyclic carbene IMe4 (IMe4 = 1,3,4,5-tetramethylimidazolin-2-ylidene) leads, after displacement of the iodide groups, to the unprecedented diiodide salt [Si(IMe4)2{C4(NEt2)4}](I)2 (3), containing a 1H-silole dication with a four-coordinate Si(IV) center.	Hydrogen	230-232	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	54-58
24939862-6	2014	Reaction of 2-I with the N-heterocyclic carbene IMe4 (IMe4 = 1,3,4,5-tetramethylimidazolin-2-ylidene) leads, after displacement of the iodide groups, to the unprecedented diiodide salt [Si(IMe4)2{C4(NEt2)4}](I)2 (3), containing a 1H-silole dication with a four-coordinate Si(IV) center.	Hydrogen	230-232	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	54-58
25053303-7	2014	The accuracy and efficiency are demonstrated in fitting both a model PES for the H2 + Cu(111) system and density functional theory points for the H2 + Ag(111) system.	Hydrogen	81-83	H2A clustered histone 11	Homo sapiens	146-153
24740791-7	2014	ANG II induced threefold increases in phosphorylated MAP kinases ERK1/2 and a onefold increase in phosphorylated sodium and hydrogen exchanger 3 (NHE3) proteins, which were also blocked by losartan and megalin-siRNA.	Hydrogen	124-132	low density lipoprotein receptor-related protein 2	Mus musculus	202-209
24867954-11	2014	E25 dimer is mainly stabilized by an N-terminal loop intersection from the CAP domains and hydrogen bonds and salt bridges involving seven highly conserved hydrophilic residues from the catalytic domains.	Hydrogen	91-99	integral membrane protein 2C	Homo sapiens	0-3
24780296-8	2014	RESULTS: Computational modeling results indicated that amoxapine and its metabolites bound in the active site of GUS and satisfied critical pharmacophore features: aromatic features near bacterial loop residue F365" and hydrogen bond toward E413.	Hydrogen	220-228	glucuronidase, beta	Mus musculus	113-116
24990797-3	2014	It revealed that glucoses can occupy the side pocket of Mb, and bind closely to one of the xenon cavities in Mb, by hydrogen bonding interactions with two propionate groups of heme as well as surrounding amino acids.	Hydrogen	116-124	myoglobin	Homo sapiens	109-111
24811178-5	2014	We provide evidence that lipin 2, like lipin 1, binds PA via the electrostatic hydrogen bond switch mechanism but has a lower rate of catalysis.	Hydrogen	79-87	lipin 1	Homo sapiens	39-46
24892388-6	2014	Stable heterointeractions between hIAPP and rIAPP were shown to arise from hydrophobic contacts and hydrogen bonds at the interface, particularly at N- and C-terminal beta-sheet regions.	Hydrogen	100-108	islet amyloid polypeptide	Rattus norvegicus	44-49
24991291-3	2014	The driving force of the supramer formation is hydrogen bonding, the polypeptide chain conformation is related to the folding of helical polyglycine II (PG II).	Hydrogen	47-55	decorin	Homo sapiens	153-158
24726919-7	2014	Moreover, native-state hydrogen exchange indicates that Hsp90 can also interact with partially folded states only transiently populated from within a thermodynamically stable, native-state ensemble.	Hydrogen	23-31	heat shock protein 90 alpha family class A member 1	Homo sapiens	56-61
24444018-7	2014	Furthermore, we observed many notable changes (such as conformation, residues motions, hydrogen bonds, and binding free energy) in the mutated GSK3beta-PKB complexes.	Hydrogen	87-95	protein tyrosine kinase 2 beta	Homo sapiens	152-155
24652202-9	2014	Ligplot shows hydrogen bondings (S16, S17, V18, G19, K20, T21, S22, S31, T33, A35, S38, T39 and G65) and hydrophobic interacting residues (F25, F32, P34, F36, V37, D62 and A64) with the GTP ligands in the binding site of Rab3A protein.	Hydrogen	14-22	RAB3A, member RAS oncogene family	Homo sapiens	221-226
24886938-4	2014	Molecular modeling studies revealed that the binding mode would be affected via forming an additional hydrogen bond by incorporating an oxygen atom on the C-2 side chain.	Hydrogen	102-110	complement C2	Homo sapiens	155-158
24773584-2	2014	When water was employed as the proton source (10 M in MeCN), CO was produced (fCO= 45% +- 6.4) near the Co(I/0) redox couple for [Co(III)N4H(Br)2](+) (E1/2 = -1.88 V FeCp2(+/0)) with simultaneous H2 evolution (fH2= 30% +- 7.8).	Hydrogen	196-198	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	104-110
24806731-6	2014	Combined experimental and computational studies have led to a proposed mechanism for hydrogen activation by [((t)bpy)2Rh(OMe)(MeOH)][OTf][TFA] that involves dissociation of MeOH, coordination of hydrogen, and 1,2-addition of hydrogen across the Rh-OMe bond.	Hydrogen	85-93	coagulation factor III, tissue factor	Homo sapiens	138-141
24806731-6	2014	Combined experimental and computational studies have led to a proposed mechanism for hydrogen activation by [((t)bpy)2Rh(OMe)(MeOH)][OTf][TFA] that involves dissociation of MeOH, coordination of hydrogen, and 1,2-addition of hydrogen across the Rh-OMe bond.	Hydrogen	195-203	coagulation factor III, tissue factor	Homo sapiens	138-141
24806731-6	2014	Combined experimental and computational studies have led to a proposed mechanism for hydrogen activation by [((t)bpy)2Rh(OMe)(MeOH)][OTf][TFA] that involves dissociation of MeOH, coordination of hydrogen, and 1,2-addition of hydrogen across the Rh-OMe bond.	Hydrogen	195-203	coagulation factor III, tissue factor	Homo sapiens	138-141
24713696-3	2014	In this work, the structure of the Nth1 14-3-3 complex and the importance of the EF-hand-like motif were investigated using site-directed mutagenesis, hydrogen/deuterium exchange coupled to mass spectrometry, chemical cross-linking, and small angle x-ray scattering.	Hydrogen	151-159	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	35-39
24599998-8	2014	Hydrogen-deuterium exchange analyses of unassembled Gag compared that of assembled VLPs showed strong protection at the SPA region, consistent with a higher-order structure.	Hydrogen	0-8	Pr76 polyprotein precursor	Rous sarcoma virus	52-55
24107872-2	2014	Compounds 13 and 14 lose H2 to give [1,3-mu-(H)-1,1-(PR3)2-3-(Py)-isonido-1,2-RhSB9H8](+), where PR3 = PMe2Ph (18), PPh3 and PMe2Ph (21), or PMePh2 (22).	Hydrogen	25-27	protein phosphatase 4 catalytic subunit	Homo sapiens	116-120
23813220-0	2014	1H, 13C and 15N resonance assignments of Ca2+-bound human S100A15.	Hydrogen	0-2	S100 calcium binding protein A7A	Homo sapiens	58-65
25007592-0	2014	[Transfer energy disposal in collisions of NaK (6(1)sigma+) with H2].	Hydrogen	65-67	TANK binding kinase 1	Homo sapiens	43-46
25007592-1	2014	The radiative lifetimes and rate coefficients for deactivation of high lying 6(1)sigma+ state of NaK by collisions with H2 were studied.	Hydrogen	120-122	TANK binding kinase 1	Homo sapiens	97-100
24453046-5	2014	Silencing of LASS2/TMSG1 gene in PC-3M-2B4 cells increased V-ATPase activity, extracellular hydrogen ion concentration and in turn the activation of secreted MMP-2 and MMP-9, which coincided with enhancing cell proliferation, cell survival, and cell invasion in vitro, as well as acceleration of prostate cancer (PCA) growth and lymph node metastases in vivo.	Hydrogen	92-100	ceramide synthase 2	Homo sapiens	13-18
24453046-5	2014	Silencing of LASS2/TMSG1 gene in PC-3M-2B4 cells increased V-ATPase activity, extracellular hydrogen ion concentration and in turn the activation of secreted MMP-2 and MMP-9, which coincided with enhancing cell proliferation, cell survival, and cell invasion in vitro, as well as acceleration of prostate cancer (PCA) growth and lymph node metastases in vivo.	Hydrogen	92-100	ceramide synthase 2	Homo sapiens	19-24
24607901-6	2014	We find that TTX occludes the entrance of NaV1.4 by forming a network of hydrogen-bonds at the outer lumen of the selectivity filter.	Hydrogen	73-81	sodium voltage-gated channel alpha subunit 4	Homo sapiens	42-48
24607901-8	2014	The acidic residues just above the selectivity filter are important in stabilizing the hydrogen-bond network between TTX and NaV1.4.	Hydrogen	87-95	sodium voltage-gated channel alpha subunit 4	Homo sapiens	125-131
24081321-3	2014	These findings suggest that HyaB and HydA can function as uptake hydrogenases that couple the oxidation of H2 to the reduction of amaranth to sustain cellular growth.	Hydrogen	107-109	nickel-dependent hydrogenase large subunit	Shewanella oneidensis MR-1	28-32
24562912-5	2014	Docking conformation analysis results showed that these potential inhibitors could bind to the CPSF30-binding site with strong hydrophobic interactions and weak hydrogen bonds.	Hydrogen	161-169	cleavage and polyadenylation specific factor 4	Homo sapiens	95-101
24520015-5	2014	Energy minima of the Ac-N(Me)-Gly-NHMe and Ac-N(Me)-Gly-NMe2 have been analyzed in terms of the possible hydrogen bonds and C = O dipole attraction.	Hydrogen	105-113	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	56-60
24422534-4	2014	Here, we demonstrate that the ADEP conformation observed in the ADEP-ClpP crystal structure is fortified by transannular hydrogen bonding and can be further stabilized by judicious replacement of constituent amino acids within the peptidolactone core structure with more conformationally constrained counterparts.	Hydrogen	121-129	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Homo sapiens	69-73
24900836-2	2014	Although most of the residues in the CD1d binding groove are hydrophobic, some of the amino acids can form hydrogen bonds.	Hydrogen	107-115	CD1d molecule	Homo sapiens	37-41
24022347-5	2014	Silicone PSA films showed higher resistance to hydrogen ion diffusion compared with EC films.	Hydrogen	47-55	aminopeptidase puromycin sensitive	Homo sapiens	9-12
24436125-3	2014	Importantly, we unearth the molecular origin of such favorable enthalpy and attribute it to the ability of H382 residue to stabilize the EGR1-DNA interaction via both intermolecular hydrogen bonding and van der Waals contacts against the backdrop of salt.	Hydrogen	182-190	early growth response 1	Homo sapiens	137-141
24141017-5	2014	Expression of HSP70 was elevated as early as 1h after the elicitation of sustained seizure activity, followed by a progressive elevation that peaked at 24h.	Hydrogen	45-47	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	14-19
24331413-0	2014	Hydrogen-rich water regulates cucumber adventitious root development in a heme oxygenase-1/carbon monoxide-dependent manner.	Hydrogen	0-8	heme oxygenase 1, chloroplastic	Cucumis sativus	74-90
24308311-3	2014	Our calculations reveal that the hydroxy group of phosphoryl plays a crucial role almost in all steps, which can not only stabilize the intermediates and transition states by intramolecular hydrogen bonds but also act as a proton donor so that the eta(1)-CH3COO(-) ligand could be protonated to form a neutral acetic acid for easy removal.	Hydrogen	190-198	secreted phosphoprotein 1	Homo sapiens	248-254
29058005-2	2017	Here we present the application of the recently developed spin-ratio scaled MP2 method (termed SRS-MP2) to six different datasets covering a wide range of interaction types from strong hydrogen bonding to van der Waals dispersion and pi-pi stacking.	Hydrogen	185-193	tryptase pseudogene 1	Homo sapiens	76-79
29195358-1	2017	A novel development is made here by inventing panorama single-cell mega-size electrochemical etching (MS-ECE) chamber systems for processing panorama position-sensitive mega-size polycarbonate ion image detectors (MS-PCIDs) of potential for many neutron and ion detection applications in particular hydrogen ions or proton tracks and images detected for the first time in polycarbonates in this study.	Hydrogen	299-307	endothelin converting enzyme 1	Homo sapiens	105-108
29195358-7	2017	Two panorama single-cell MS-ECE chamber systems (circular and rectangular shapes) constructed were efficiently applied to processing the MS-PCIDs for 4pi ion emission image detection of different gases in particular hydrogen ions or protons in a 3.5 kJ plasma focus device (PFD as uniquely observed by the unaided eyes).	Hydrogen	216-224	endothelin converting enzyme 1	Homo sapiens	28-31
29062134-7	2017	During P2Y1R activation, the cytoplasmic end of helix VI shifts outward 9.1 A, the Ser1463.47-Tyr2375.58 hydrogen bond breaks, a Tyr2375.58-Val2626.37 hydrogen bond forms, and the conformation of the chi1 rotamer of Phe2696.44 changes from parallel to perpendicular to helix VI.	Hydrogen	105-113	purinergic receptor P2Y1	Homo sapiens	7-12
29062134-7	2017	During P2Y1R activation, the cytoplasmic end of helix VI shifts outward 9.1 A, the Ser1463.47-Tyr2375.58 hydrogen bond breaks, a Tyr2375.58-Val2626.37 hydrogen bond forms, and the conformation of the chi1 rotamer of Phe2696.44 changes from parallel to perpendicular to helix VI.	Hydrogen	151-159	purinergic receptor P2Y1	Homo sapiens	7-12
29552652-4	2017	The principal component analysis (PCA) of the 1H NMR spectra showed a clear discrimination between those samples within PC1 and PC2.	Hydrogen	46-48	polycystin 1, transient receptor potential channel interacting	Homo sapiens	120-123
28741930-0	2017	N-Terminal Acetylation Preserves alpha-Synuclein from Oligomerization by Blocking Intermolecular Hydrogen Bonds.	Hydrogen	97-105	synuclein alpha	Homo sapiens	33-48
28741930-5	2017	Replica-exchange molecular dynamics simulations further revealed that addition of an acetyl group at the N-terminus disrupts intermolecular hydrogen bonds, which slows down the initial alpha-Syn oligomerization.	Hydrogen	140-148	synuclein alpha	Homo sapiens	185-194
28993621-5	2017	The IL-1alpha/aptamer interface is composed of unusual polar and hydrophobic elements, along with an elaborate hydrogen bonding network that is mediated by sodium ion.	Hydrogen	111-119	interleukin 1 alpha	Homo sapiens	4-13
24496246-10	2014	Transcript levels of IP3 receptor IP3R2 and of IP3R2 regulating transcription factor ETS1 were significantly higher in akt2(+/+) than in akt2(-/-) DCs prior to maturation and were upregulated by LPS stimulation (1h) in akt2(+/+) and to a lower extent in akt2(-/-) DCs.	Hydrogen	212-214	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	21-33
24496246-10	2014	Transcript levels of IP3 receptor IP3R2 and of IP3R2 regulating transcription factor ETS1 were significantly higher in akt2(+/+) than in akt2(-/-) DCs prior to maturation and were upregulated by LPS stimulation (1h) in akt2(+/+) and to a lower extent in akt2(-/-) DCs.	Hydrogen	212-214	thymoma viral proto-oncogene 2	Mus musculus	119-123
24191706-0	2013	Characterizing the dynamics of alpha-synuclein oligomers using hydrogen/deuterium exchange monitored by mass spectrometry.	Hydrogen	63-71	synuclein alpha	Homo sapiens	31-46
2692710-11	1989	The active-site glycines are located in solvent-exposed loops, so their apparent solvent inaccessibility may result from strong hydrogen bond formation between glycine amide protons and bound guanine diphosphate and/or other nearby groups in p21.	Hydrogen	128-136	H3 histone pseudogene 16	Homo sapiens	242-245
24191706-3	2013	Using hydrogen/deuterium exchange monitored by mass spectrometry (HDX-MS), we have analyzed the structural dynamics of soluble alphaSN oligomers.	Hydrogen	6-14	synuclein alpha	Homo sapiens	127-134
24266513-5	2013	Circular dichroism spectroscopy, acrylamide quenching, and amide hydrogen-deuterium exchange mass spectrometry experiments indicate that the loss of activity is caused by the introduction of local disorder at the active site of GSTP1-1.	Hydrogen	65-73	glutathione S-transferase pi 1	Homo sapiens	228-235
29077483-8	2017	Among ligands, 5j (sodium (3R,5R)-7-(3-(N,N-dimethylsulfamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate) could inhibit HMGCR enzyme in inhibitory binding site with affinity value -12.17 kcal/mol and binding energy -94.10 kcal/mol through 5 hydrogen bonds.	Hydrogen	279-287	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	158-163
2591533-2	1989	Both mt-thioredoxins can serve as hydrogen donor for E. coli ribonucleotide reductase but only the plant protein activates spinach chloroplast NADP malate dehydrogenase in vitro.	Hydrogen	34-42	thioredoxin	Homo sapiens	8-20
28888820-6	2017	Molecular docking results indicated that compound 13 bonded with telomerase reverse transcriptase (TERT) through multiple interactions, including hydrogen bonding and hydrophobic interactions.	Hydrogen	146-154	telomerase reverse transcriptase	Homo sapiens	65-97
28888820-6	2017	Molecular docking results indicated that compound 13 bonded with telomerase reverse transcriptase (TERT) through multiple interactions, including hydrogen bonding and hydrophobic interactions.	Hydrogen	146-154	telomerase reverse transcriptase	Homo sapiens	99-103
28846421-0	2017	Operando Spectroscopic Analysis of CoP Films Electrocatalyzing the Hydrogen-Evolution Reaction.	Hydrogen	67-75	caspase recruitment domain family member 16	Homo sapiens	35-38
24186152-3	2013	Nevertheless they are attractive for C-H   P and C-H   S hydrogen bonding in the solid state.	Hydrogen	57-65	calcineurin like EF-hand protein 1	Homo sapiens	37-52
2611784-2	1989	The product, which was detected by an anti-Lea antibody in a novel ELISA assay, was isolated and shown to be the human Lea blood-group determinant beta-D-Galp-(1----3)-[alpha-L-Fucp-(1----4)]-beta-D-GlcpNAc-OR by 1H-n.m.r.	Hydrogen	213-215	galanin like peptide	Homo sapiens	154-158
24527493-0	2013	Retraction notice to ""1H-MRS can monitor metabolites changes of lateral intraventricular BDNF infusion into a mouse model of Alzheimer"s disease in vivo"" [Neuroscience 245 (2013) 40-49].	Hydrogen	23-25	brain derived neurotrophic factor	Mus musculus	90-94
28777576-3	2017	Two molecules in the unit cell of the monoclinic P21 crystal form a net of NH   OS and C*H   OS hydrogen bonds.	Hydrogen	96-104	H3 histone pseudogene 16	Homo sapiens	49-52
2790048-6	1989	The relative affinities shown by these analogues indicated H-bonds from the carrier to the C-3, C-4 and C-5 hydroxyl oxygens and from the C-1 and C-3 hydroxyl hydrogens to the binding site.	Hydrogen	159-168	complement C4A (Rodgers blood group)	Homo sapiens	96-99
28796947-3	2017	The experimental results are consistent with an ab initio conformation calculated at the MP2/6-311++G(d,p) level that involves the lowest energy 3-aminopropanol monomer and consists of a hydrogen bonding network.	Hydrogen	187-195	tryptase pseudogene 1	Homo sapiens	89-92
28653320-0	2017	pi   H+    pi Hydrogen Bonds and Their Lithium and Gold Analogues: MP2 and CASPT2 Calculations.	Hydrogen	14-22	tryptase pseudogene 1	Homo sapiens	67-70
24351832-6	2013	Finally, the inclusion complex formation, hydrogen bonding, and pi-pi interaction between the betaCD-IL, benzyl paraben (ArP), and DC 193C were proven using 1H NMR and 2D NOESY spectroscopy.	Hydrogen	157-159	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	121-124
24195762-0	2013	Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors.	Hydrogen	42-50	MER proto-oncogene, tyrosine kinase	Homo sapiens	117-120
28966947-7	2017	The structural integrity of the final recombinant p300-CH1 has been verified to be optimal using onedimensional 1H NMR spectroscopy and circular dichroism.	Hydrogen	112-114	SUN domain containing ossification factor	Homo sapiens	55-58
2689368-4	1989	Kinetics of mEGF proteolytic degradation follows a two-state time-course: native mEGF being converted into Des(49-53)mEGF with an apparent half-time of 10 min; and Des(49-53)mEGF subsequently hydrolyzed to Des(46-53)mEGF with an apparent half-time of 7 h. Native mEGF and its proteolytic fragments have been characterized by 1H-n.m.r.	Hydrogen	325-327	epidermal growth factor	Mus musculus	12-16
24076327-9	2013	Autodock simulations predicted that curcumin could bind to CBR1 with two hydrogen bonds.	Hydrogen	73-81	carbonyl reductase 1	Rattus norvegicus	59-63
2575093-1	1989	We have established a simple procedure for the in situ analysis of stereospecificity of an NAD(P)-dependent dehydrogenase for C-4 hydrogen transfer of NAD(P)H by means of glutamate racemase [EC 5.1.13] and glutamate dehydrogenase [EC 1.4.1.3].	Hydrogen	110-118	complement C4A (Rodgers blood group)	Homo sapiens	126-129
24248473-5	2013	While overall structure of TRPV3-ARD is similar to ARDs from other members of TRPV subfamily; it, however, features a noticeable finger 3 loop that bends over and is stabilized by a network of hydrogen bonds and hydrophobic packing, instead of being flexible as seen in known TRPV-ARD structures.	Hydrogen	193-201	Yip1 domain family member 3	Homo sapiens	129-137
24224850-7	2013	Such differences are traced to changes in actin-myosin electrostatic interactions (i.e., hydrogen bonds and salt bridges) that are highly dynamic and involve several flexible actin-binding loops.	Hydrogen	89-97	myosin heavy chain 14	Homo sapiens	48-54
24013856-1	2013	The d(1) tungsten-alkylidyne radical [W(CPh)(dppe)2Cl](+) reacts with H2 to give the d(0) hydride [W(CPh)(H)(dppe)2Cl](+), which on deprotonation yields the d(2) photoredox chromophore W(CPh)(dppe)2Cl.	Hydrogen	70-72	carboxypeptidase E	Homo sapiens	40-43
28836776-6	2017	On the basis of density functional theory (DFT) calculations, Ru2(OH)(OH2) was predicted to be thermodynamically stable by 13.3 kJ mol-1 in water compared to Ru2(mu-OH) because of the specially stabilized core structure by multiple hydrogen-bonding interactions involving aquo, hydroxo, and L backbone ligands.	Hydrogen	232-240	doublecortin domain containing 2	Homo sapiens	62-65
26800850-7	2017	Furthermore, mutant PTEN protein structures also showed a significant variation in the solvent accessible surface area and hydrogen bond frequencies from the native PTEN structure.	Hydrogen	123-131	phosphatase and tensin homolog	Homo sapiens	20-24
26800850-7	2017	Furthermore, mutant PTEN protein structures also showed a significant variation in the solvent accessible surface area and hydrogen bond frequencies from the native PTEN structure.	Hydrogen	123-131	phosphatase and tensin homolog	Homo sapiens	165-169
28820529-2	2017	Encounters between microhydrated superoxide and formic acid were found to result in a number of different reactions, including (a) proton transfer, (b) ligand exchange, (c) H2-elimination (affording microhydrated CO4 -), and (d) dihydrogen transfer (affording H2O2 and microhydrated CO2 -).	Hydrogen	173-175	complement C4A (Rodgers blood group)	Homo sapiens	213-216
24013856-1	2013	The d(1) tungsten-alkylidyne radical [W(CPh)(dppe)2Cl](+) reacts with H2 to give the d(0) hydride [W(CPh)(H)(dppe)2Cl](+), which on deprotonation yields the d(2) photoredox chromophore W(CPh)(dppe)2Cl.	Hydrogen	70-72	carboxypeptidase E	Homo sapiens	101-104
24013856-1	2013	The d(1) tungsten-alkylidyne radical [W(CPh)(dppe)2Cl](+) reacts with H2 to give the d(0) hydride [W(CPh)(H)(dppe)2Cl](+), which on deprotonation yields the d(2) photoredox chromophore W(CPh)(dppe)2Cl.	Hydrogen	70-72	carboxypeptidase E	Homo sapiens	101-104
2575093-4	1989	Therefore, if 1H is fully retained at C-4 of NAD(P)+ after incubation of a reaction mixture containing both the enzymes and a dehydrogenase to be tested, the stereospecificity of the dehydrogenase is the same as that of glutamate dehydrogenase.	Hydrogen	14-16	complement C4A (Rodgers blood group)	Homo sapiens	38-41
2506074-0	1989	Complete assignment of the 1H NMR spectrum of a synthetic zinc finger from Xfin.	Hydrogen	27-29	zinc finger protein 208 L homeolog	Xenopus laevis	75-79
23948506-0	2013	Activation of ClpP protease by ADEP antibiotics: insights from hydrogen exchange mass spectrometry.	Hydrogen	63-71	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Homo sapiens	14-18
23948506-7	2013	Here, we use hydrogen/deuterium exchange (HDX) mass spectrometry to obtain complementary insights into the ClpP behavior with and without ADEP1.	Hydrogen	13-21	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Homo sapiens	107-111
28791768-7	2017	In electrocatalytic aspects, layered CoTe1.8 and NiTe2 demonstrate low overpotentials and small Tafel slopes that are quintessential features of hydrogen evolution electrocatalysts.	Hydrogen	145-153	family with sequence similarity 189 member B	Homo sapiens	37-42
2752056-0	1989	1H-NMR and protection studies of interactions between ligands and bovine pancreatic phospholipase A2.	Hydrogen	0-2	LOC104974671	Bos taurus	84-100
28489258-6	2017	The H2 S donor based on water-soluble polymer was applied in photocontrolled inhibition of P-selectin expression on human platelets and subsequent regulation of platelet aggregation.	Hydrogen	4-6	selectin P	Homo sapiens	91-101
24276616-5	2013	In this study, we computationally analyzed the role of this water molecule as a putative hydrogen bond donor/acceptor moiety in the agonist binding site of the three most relevant heteromeric (alpha4beta2, alpha3beta4) and homomeric (alpha7) neuronal nicotinic acetylcholine receptor (nAChR) subtypes.	Hydrogen	89-97	cholinergic receptor nicotinic alpha 7 subunit	Homo sapiens	234-283
24013296-1	2013	A cobalt complex with a tripyridine-diamine pentadentate ligand was found to be a highly active catalyst for electrochemical H2 production from neutral water, with an activity of 860 mol H2 (mol cat)(-1) h(-1) (cm(2) Hg)(-1) over 60 h CPE experiment at -1.25 V in a pH 7 phosphate buffer solution, without considerable deactivation.	Hydrogen	125-127	carboxypeptidase E	Homo sapiens	235-238
2752056-2	1989	Their areas of interaction on the enzyme were further delineated using observations of chemical shift changes of assigned aromatic signals in the 1H-NMR spectrum of PLA2, while the bound conformations of two amine inhibitors were revealed using transferred nuclear Overhauser effects.	Hydrogen	146-148	LOC104974671	Bos taurus	165-169
24013296-1	2013	A cobalt complex with a tripyridine-diamine pentadentate ligand was found to be a highly active catalyst for electrochemical H2 production from neutral water, with an activity of 860 mol H2 (mol cat)(-1) h(-1) (cm(2) Hg)(-1) over 60 h CPE experiment at -1.25 V in a pH 7 phosphate buffer solution, without considerable deactivation.	Hydrogen	187-189	carboxypeptidase E	Homo sapiens	235-238
2722875-2	1989	When the reactions catalyzed by alanine racemase (EC 5.1.1.1) and L-alanine dehydrogenase (EC 1.4.1.1), which is pro-R specific for the C-4 hydrogen transfer of NADH, are coupled in 2H2O, [4R-2H]NADH is exclusively produced.	Hydrogen	78-86	complement C4A (Rodgers blood group)	Homo sapiens	136-139
24024653-3	2013	DFT calculations at the B3LYP/6-311++G(d,p) level show that HCN can form in-plane hydrogen bonds to ring hydrogens, or bind electrostatically to positively charged carbon centers in the ring.	Hydrogen	82-90	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	60-63
24024653-3	2013	DFT calculations at the B3LYP/6-311++G(d,p) level show that HCN can form in-plane hydrogen bonds to ring hydrogens, or bind electrostatically to positively charged carbon centers in the ring.	Hydrogen	105-114	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	60-63
28701464-12	2017	We conclude that the most likely catalytic mechanism begins with abstraction of a hydrogen atom from C-4 (or possibly C-3) initiating the desaturation pathway, followed by a sequential abstraction of a hydrogen atom or proton-coupled electron transfer.	Hydrogen	82-90	complement C4A (Rodgers blood group)	Homo sapiens	101-104
28701464-12	2017	We conclude that the most likely catalytic mechanism begins with abstraction of a hydrogen atom from C-4 (or possibly C-3) initiating the desaturation pathway, followed by a sequential abstraction of a hydrogen atom or proton-coupled electron transfer.	Hydrogen	202-210	complement C4A (Rodgers blood group)	Homo sapiens	101-104
28474426-4	2017	In this Review, we summarize recent progress in Mox C electrocatalysts for hydrogen evolution reaction (HER).	Hydrogen	75-83	monooxygenase DBH like 1	Homo sapiens	48-51
24024653-8	2013	Further HCN molecules can bind directly to unoccupied ring CH hydrogens or bind to the first-shell HCN molecules to form linear HCN---HCN--- hydrogen bonded chains.	Hydrogen	62-71	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	8-11
24024653-8	2013	Further HCN molecules can bind directly to unoccupied ring CH hydrogens or bind to the first-shell HCN molecules to form linear HCN---HCN--- hydrogen bonded chains.	Hydrogen	62-70	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	8-11
24116097-12	2013	Effects from SMX binding are amplified and traverse longer distances through internal TCR hydrogen bonding networks, controlling the overall TCR conformation.	Hydrogen	90-98	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	86-89
24116097-12	2013	Effects from SMX binding are amplified and traverse longer distances through internal TCR hydrogen bonding networks, controlling the overall TCR conformation.	Hydrogen	90-98	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	141-144
2722875-4	1989	We have established a simple procedure for the in situ analysis of stereospecificity of C-4 hydrogen transfer of NADH by an NAD-dependent dehydrogenase by combination with either of the above two couples of enzymes in the same reaction mixture.	Hydrogen	92-100	complement C4A (Rodgers blood group)	Homo sapiens	88-91
24116148-6	2013	Compound 1h also reduced secretion of IL-6 and tumor necrosis factor-alpha by LPS-activated J774A.1 murine macrophage cells, primary mice peritoneal macrophages, and JAWSII murine bone marrow-derived dendritic cells and reduced NLRP3 inflammasome-mediated interleukin-1beta (IL-1beta) secretion by LPS + adenosine triphosphate-activated J774A.1 and JAWSII cells.	Hydrogen	9-11	NLR family, pyrin domain containing 3	Mus musculus	228-233
24116148-9	2013	They also show how compound 1h regulates inflammation and suggest it may be a new source for the development of anti-inflammatory agents to ameliorate inflammation- and NLRP3 inflammasome-related diseases.	Hydrogen	28-30	NLR family, pyrin domain containing 3	Mus musculus	169-174
2722875-5	1989	When the C-4 hydrogen of NAD+ is fully retained after sufficient incubation, the stereospecificity of hydrogen transfer by a dehydrogenase is the same as that of alanine dehydrogenase or leucine dehydrogenase.	Hydrogen	13-21	complement C4A (Rodgers blood group)	Homo sapiens	9-12
24132903-6	2013	We use this approach to determine if prior data implicating the sodium/hydrogen exchanger 9 gene (SLC9A9) in ADHD implicate sodium/hydrogen exchange (NHE) inhibitors as potential treatments.	Hydrogen	71-79	solute carrier family 9 member A9	Homo sapiens	98-104
2722875-5	1989	When the C-4 hydrogen of NAD+ is fully retained after sufficient incubation, the stereospecificity of hydrogen transfer by a dehydrogenase is the same as that of alanine dehydrogenase or leucine dehydrogenase.	Hydrogen	102-110	complement C4A (Rodgers blood group)	Homo sapiens	9-12
28777545-4	2017	Exposure to H2 causes a resistance increase, as Pd metal is converted into more resistive palladium hydride (PdHx).	Hydrogen	12-14	pyruvate dehydrogenase complex component X	Homo sapiens	109-113
2722875-6	1989	However, when the C-4 hydrogen of NAD+ is exchanged with deuterium, the enzyme to be examined shows the different stereospecificity from alanine dehydrogenase or leucine dehydrogenase.	Hydrogen	22-30	complement C4A (Rodgers blood group)	Homo sapiens	18-21
2976601-8	1988	With the aid of NMR spectrometry, the two replaced hydrogen atoms are found to be incorporated into the C-2 and C-6 positions of the bicyclo-diyne-ene ring of NCS-chrom and are derived neither from borodeuteride nor from the hydroxyl functions of the solvents.	Hydrogen	51-59	complement C2	Homo sapiens	104-107
28555251-8	2017	TNFr1 expression on non-classical monocytes was "likely attenuated" (77.6% likelihood effect) from BL to 1H in the SUPP group compared with PL (d = 0.69; mean effect: 330 +- 430 RFU).	Hydrogen	105-107	TNF receptor superfamily member 1A	Homo sapiens	0-5
23726992-4	2013	METHODS: To investigate the structural basis of interaction between Nth1 and Bmh1, we used hydrogen/deuterium exchange coupled to mass spectrometry, circular dichroism spectroscopy and homology modeling to identify structural changes occurring upon the complex formation.	Hydrogen	91-99	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	68-72
23988352-3	2013	The present study reveals that the analog bearing a triazole between Phe and Leu retains some potency, more than all the others, suggesting that the hydrogen bond acceptor capacity of the last amide of Leu-enkephalin is essential for the biological activity of the peptide.	Hydrogen	149-157	prodynorphin	Homo sapiens	202-216
2462549-1	1988	The capacity of various blood-borne cells, whether normal or malignant, to extravasate was found to correlate with heparanase-mediated degradation of HS in subendothelial ECM.	Hydrogen	150-152	multimerin 1	Homo sapiens	171-174
23722556-0	2013	A new theoretical analysis of the cooperative effect in T-shaped hydrogen complexes of CnHm   HCN   HW with n = 2, m = 2 or 4, and W = F or CN.	Hydrogen	65-73	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	94-97
28765527-5	2017	Hydrogen/deuterium exchange mass spectrometry (HDX-MS) and molecular dynamics studies revealed that Ca2+ binding to the EF-hands of hSCGN induces significant structural changes that affect the solvent exposure of N-terminal region, and hence the redox sensitivity of the Cys193 residue.	Hydrogen	0-8	secretagogin, EF-hand calcium binding protein	Homo sapiens	132-137
28475227-3	2017	However, it was recently reported that high-temperature carbon-reactor methods for measuring the hydrogen isotopic composition of nitrogenous organic materials is biased by the production of HCN in the reactor.	Hydrogen	97-105	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	191-194
23722556-1	2013	In this theoretical work, a new idea about cooperativity in intermolecular clusters of CnHm   HCN   HW stabilized by hydrogen bonds composed by lone-electron pairs (nitrogen) and pi clouds (C = C and C   C) as proton acceptors is developed.	Hydrogen	117-125	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	94-97
3289536-7	1988	These data demonstrate that GnRH-stimulated synthesis of LH polypeptide chains occurs after a lag of approximately 1h and involves mechanisms different from those governing the stimulation of LH release.	Hydrogen	115-117	gonadotropin releasing hormone 1	Rattus norvegicus	28-32
25509392-10	2013	Stability of the LH1 complex is probably based primarily on the highly specific hydrophobic interactions between the surfaces of individual polypeptide chains, since the presence of hydrogen bonds results in autonomy of each alphabeta3BChl2 subunit, rather than in stabilization of the LH1 complex as a whole.	Hydrogen	182-190	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	17-20
28570819-1	2017	In this work, we tentatively propose that the hydrogen-bonding strength EHB (referring to the minimal hydrogen-bonding energy) and its corresponding hydrogen-bond (HB) distance (referring to the optimal HB distance dHB) for simple mono-HB systems have an exponential relationship on the basis of MP2 and DFT computational results.	Hydrogen	46-54	tryptase pseudogene 1	Homo sapiens	296-299
28570819-1	2017	In this work, we tentatively propose that the hydrogen-bonding strength EHB (referring to the minimal hydrogen-bonding energy) and its corresponding hydrogen-bond (HB) distance (referring to the optimal HB distance dHB) for simple mono-HB systems have an exponential relationship on the basis of MP2 and DFT computational results.	Hydrogen	102-110	tryptase pseudogene 1	Homo sapiens	296-299
28570819-1	2017	In this work, we tentatively propose that the hydrogen-bonding strength EHB (referring to the minimal hydrogen-bonding energy) and its corresponding hydrogen-bond (HB) distance (referring to the optimal HB distance dHB) for simple mono-HB systems have an exponential relationship on the basis of MP2 and DFT computational results.	Hydrogen	102-110	tryptase pseudogene 1	Homo sapiens	296-299
3415970-0	1988	Location of an alpha-helix in fragment 96-133 from bovine somatotropin by 1H NMR spectroscopy.	Hydrogen	74-76	somatotropin	Bos taurus	58-70
23871693-5	2013	Finally, treatment of mIMCD-3 cells cultured in high osmolality medium for 1h with 1nM NDP-gamma2MSH causes a reduction in expression of serum- and glucocorticoid-induced kinase (sgk1) and a reduction in expression and cell surface abundance of the alpha subunit of ENaC.	Hydrogen	75-77	serum/glucocorticoid regulated kinase 1	Mus musculus	179-183
3408716-3	1988	1H NMR spectroscopy has been used to characterize these proteins and to compare them to one another and to native antithrombin III.	Hydrogen	0-2	serpin family C member 1	Homo sapiens	114-130
23608100-0	2013	1H-MRS can monitor metabolites changes of lateral intraventricular BDNF infusion into a mouse model of Alzheimer"s disease in vivo.	Hydrogen	0-2	brain derived neurotrophic factor	Mus musculus	67-71
24062826-4	2013	The generation of CHBr3 was confirmed by NMR spectroscopy and GC-MS spectrometry analysis, indicating that the present bromination involves the homolytic cleavage of a C-Br bond in CBr4 followed by radical abstraction of a hydrogen atom from a hydrocarbon.	Hydrogen	223-231	carbonyl reductase 4	Homo sapiens	181-185
28740230-5	2017	The discrimination between NPC1 (both miglustat treated and untreated) and healthy controls was dominated by lipoprotein triacylglycerol 1H NMR resonances and isoleucine.	Hydrogen	137-139	NPC intracellular cholesterol transporter 1	Homo sapiens	27-31
28515318-6	2017	Hydrogen-deuterium exchange MS revealed that membrane-resident HRas, but not soluble HRas, enhances conformational changes associated with membrane binding by increasing membrane recruitment of both p110alpha and p110delta.	Hydrogen	0-8	HRas proto-oncogene, GTPase	Homo sapiens	63-67
2898949-2	1988	The C-2 histidyl regions of the 1H NMR spectra of insulin species containing respectively one Ca2+ and two Zn2+/hexamer and three Cd2+/hexamer have been assigned.	Hydrogen	32-34	complement C2	Homo sapiens	4-7
28608669-0	2017	One-pot Synthesis of CdS Irregular Nanospheres Hybridized with Oxygen-Incorporated Defect-Rich MoS2 Ultrathin Nanosheets for Efficient Photocatalytic Hydrogen Evolution.	Hydrogen	150-158	CDP-diacylglycerol synthase 1	Homo sapiens	21-24
28608669-1	2017	Robust and highly active photocatalysts, CdS@MoS2, for hydrogen evolution were successfully fabricated by one-step growth of oxygen-incorporated defect-rich MoS2 ultrathin nanosheets on the surfaces of CdS with irregular fissures.	Hydrogen	55-63	CDP-diacylglycerol synthase 1	Homo sapiens	41-44
28608669-1	2017	Robust and highly active photocatalysts, CdS@MoS2, for hydrogen evolution were successfully fabricated by one-step growth of oxygen-incorporated defect-rich MoS2 ultrathin nanosheets on the surfaces of CdS with irregular fissures.	Hydrogen	55-63	CDP-diacylglycerol synthase 1	Homo sapiens	202-205
28608669-4	2017	The high hydrogen evolution activity is attributed to several merits: (1) the intimate heterojunctions formed between the MoS2 and CdS can effectively enhance the charge transfer ability and retard the recombination of electron-hole pairs; and (2) the defects in the MoS2 provide additional active S atoms on the exposed edge sites, and the incorporation of O reduces the energy barrier for H2 evolution and increases the electric conductivity of the MoS2.	Hydrogen	9-17	CDP-diacylglycerol synthase 1	Homo sapiens	131-134
28608669-4	2017	The high hydrogen evolution activity is attributed to several merits: (1) the intimate heterojunctions formed between the MoS2 and CdS can effectively enhance the charge transfer ability and retard the recombination of electron-hole pairs; and (2) the defects in the MoS2 provide additional active S atoms on the exposed edge sites, and the incorporation of O reduces the energy barrier for H2 evolution and increases the electric conductivity of the MoS2.	Hydrogen	391-393	CDP-diacylglycerol synthase 1	Homo sapiens	131-134
23927240-10	2013	For complete basis set estimates of hydrogen transfer reaction energies, the OCEPA(0) method again exhibits a substantially better performance than CEPA(0), providing a mean absolute error of 0.7 kcal mol(-1), which is more than 6 times lower than that of CEPA(0) (4.6 kcal mol(-1)), and comparing to MP2 (7.7 kcal mol(-1)) there is a more than 10-fold reduction in errors.	Hydrogen	36-44	tryptase pseudogene 1	Homo sapiens	301-304
3289613-4	1988	1H NMR spectra of enzyme/D-gluco-octenitol digests in D2O showed that the alpha-anomer of [2-2H]-D-gluco-octulose was exclusively produced by each alpha-glucosidase, whereas the beta-anomer was formed by action of the trehalase.	Hydrogen	0-2	sucrase-isomaltase	Homo sapiens	147-164
23759948-7	2013	Furthermore, TERE1 expression increased mitochondrial oxygen consumption and hydrogen production, oxidative stress and NO production.	Hydrogen	77-85	UbiA prenyltransferase domain containing 1	Homo sapiens	13-18
28692096-3	2017	Here, we present the integral cross sections [sigma(v+; N+)"s] for the H2+(v+ = 1-3; N+ = 0-3) + Ne   NeH+ + H reaction observed in the center-of-mass kinetic energy (Ecm) range of 0.05-2.00 eV.	Hydrogen	71-73	multimerin 1	Homo sapiens	167-170
28510292-4	2017	As a result, the optimized Cd/CdO/CdS heterojunction photoanode showed outstanding and long-term photoelectrochemical activity for water splitting, with a current density of 3.52 mA cm-2 , or a benchmark specific hydrogen production rate of 1.65 mumol cm-2  min-1 at -0.3 V versus Ag/AgCl, by using the environmental pollutants of sulfide and sulfite as sacrificial agents.	Hydrogen	213-221	CDP-diacylglycerol synthase 1	Homo sapiens	34-37
2837287-1	1988	Proton nuclear magnetic resonance (1H NMR) assignments for the murine epidermal growth factor (mEGF) in aqueous solution were determined by using two-dimensional NMR at pH 3.1 and 28 degrees C. The assignments are complete for all backbone hydrogen atoms, with the exception of the N-terminal amino group, and for 46 of the 53 side chains.	Hydrogen	35-37	epidermal growth factor	Mus musculus	70-93
23620226-0	2013	A B3LYP and MP2(full) theoretical investigation into the cooperativity effect between dihydrogen-bonding and H-M   pi (M = Li, Na, K) interactions among HF, MH with the pi-electron donor C2H2, C2H4 or C6H6.	Hydrogen	86-96	tryptase pseudogene 1	Homo sapiens	12-15
3260591-0	1988	Complete sequence-specific 1H nuclear magnetic resonance assignments for mouse epidermal growth factor.	Hydrogen	27-29	epidermal growth factor	Mus musculus	79-102
23688558-8	2013	These results support the hypothesis that the modified hydrogen bonding donor/acceptors in DHP-mimic dihydropyrimidines and 4H-pyrans can interact differently with DHP binding sites, but, in addition, the data suggest that the binding sites of DHP in CaV1.3 and CaV1.2 LTCCs are very similar.	Hydrogen	55-63	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	251-257
28613810-2	2017	Herein, a MOF-derived phosphorization approach was developed to produce Ni2P-CoP bimetallic phosphides as bifunctional electrocatalysts for both hydrogen and oxygen evolution reactions (HER and OER).	Hydrogen	145-153	caspase recruitment domain family member 16	Homo sapiens	77-80
28652325-5	2017	Molecular modeling indicates that CD16A TM residues F202, D205, and T206 form the core of the membrane-embedded trimeric interface by establishing highly favorable contacts to the signaling modules through rearrangement of a hydrogen bond network previously identified in the CD247 TM dimer solution NMR structure.	Hydrogen	225-233	CD247 molecule	Homo sapiens	276-281
3260591-1	1988	The 1H NMR spectrum of the mouse epidermal growth factor (53 residues) was analyzed with the use of two-dimensional NMR techniques.	Hydrogen	4-6	epidermal growth factor	Mus musculus	33-56
24079236-2	2013	The structure of CTPP-PEG-PCL had been identified by 1H-NMR spectra.	Hydrogen	53-55	CTPP	Homo sapiens	17-21
2832522-0	1988	The principal hydrogen donor for the herpes simplex virus type 1-encoded ribonucleotide reductase in infected cells is a cellular thioredoxin.	Hydrogen	14-22	thioredoxin	Homo sapiens	130-141
23840430-3	2013	Molecular docking was used to reproduce the crystallographic binding mode of cyclic inosine 5"-diphosphoribose (N1-cIDPR) with CD38, revealing an exploitable pocket and predicting the potential to introduce an extra hydrogen bond interaction with Asp-155.	Hydrogen	216-224	CD38 molecule	Homo sapiens	127-131
23840430-6	2013	Crystallography of a complex of cyclic ADP-carbocyclic ribose (cADPcR, IC50 129 microM) with CD38 illustrated that Glu-146 hydrogen bonds with the ligand N6-amino group.	Hydrogen	123-131	CD38 molecule	Homo sapiens	93-97
28808414-8	2017	Deprotonation of [H1H]0 with potassium tert-butoxide gave [HFe2(pdt)(CO)2(PNH)2]- ([1H]-), which was characterized spectroscopically.	Hydrogen	19-21	hemojuvelin BMP co-receptor	Homo sapiens	59-63
2832522-1	1988	In this study herpes simplex virus type 1-encoded ribonucleotide reductase was shown to be able to utilize thioredoxin purified from the cyanobacterium Anabaena variabilis as a hydrogen donor for the enzyme.	Hydrogen	177-185	thioredoxin	Homo sapiens	107-118
23536116-1	2013	Thermodynamic data for the reversible formation of cis-RuCl2(P-N)(PPh3)(eta(2)-H2) () from trans-RuCl2(P-N)(PPh3) in C6D6 are determined by variable temperature (31)P{(1)H} and (1)H NMR spectroscopy; P-N = o-diphenylphosphino-N,N"-dimethylaniline.	Hydrogen	79-81	protein phosphatase 4 catalytic subunit	Homo sapiens	66-70
23536116-1	2013	Thermodynamic data for the reversible formation of cis-RuCl2(P-N)(PPh3)(eta(2)-H2) () from trans-RuCl2(P-N)(PPh3) in C6D6 are determined by variable temperature (31)P{(1)H} and (1)H NMR spectroscopy; P-N = o-diphenylphosphino-N,N"-dimethylaniline.	Hydrogen	79-81	protein phosphatase 4 catalytic subunit	Homo sapiens	108-112
2832522-5	1988	No evidence for the existence of a major virus-induced thioredoxin was obtained, suggesting that the host cell thioredoxin functions as the hydrogen donor for the herpes simplex virus type 1 ribonucleotide reductase in the infected cell.	Hydrogen	140-148	thioredoxin	Homo sapiens	111-122
3338997-7	1988	The downfield shift of the 31P resonances of cobalamins upon binding to the haptocorrin cannot be due to hydrogen bonding phosphodiester moiety or displacement of the axial base by a group on the protein.	Hydrogen	105-113	transcobalamin 1	Homo sapiens	76-87
23747902-4	2013	Furthermore, docking and dynamics simulation studies reveal that the designed hybrid compounds have favorable binding affinity and stability in both pterin-binding site of DHPS and folate-binding site of DHFR by forming strong hydrogen bonds and hydrophobic interactions with key active-site residues.	Hydrogen	227-235	sul1	Pseudomonas aeruginosa	172-176
28629119-7	2017	Molecular docking analyses were conducted for potential AChE and BChE inhibitors, and the results demonstrated that the peripheral anionic sites of target proteins were predominant binding sites for these compounds through hydrogen bonds and halogen interactions instead of hydrophobic interactions in the catalytic active site.	Hydrogen	223-231	butyrylcholinesterase	Homo sapiens	65-69
28617332-0	2017	Dynamic Allostery Modulates Catalytic Activity by Modifying the Hydrogen Bonding Network in the Catalytic Site of Human Pin1.	Hydrogen	64-72	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	120-124
2895992-9	1988	The drugs appeared to affect the hydrogen donor system of the reductase complex, since the activity of the ribonucleotide reductase enzyme itself was not affected but both thioredoxin and glutaredoxin were markedly inactivated by the sesquiterpene lactones.	Hydrogen	33-41	thioredoxin	Homo sapiens	172-183
23563626-9	2013	In conclusion, hydrogen exhibits significant protective effects against AGE-induced EC injury possibly through reducing ROS generation, intracellular antioxidant enzyme system protection and elevation of the Bcl-2/Bax ratio.	Hydrogen	15-23	BCL2 associated X, apoptosis regulator	Rattus norvegicus	214-217
3359996-3	1988	Trifluoroethanol increases the helix contents of H1, H5 and their carboxy-terminal fragments, presumably through promotion of axial hydrogen bonding.	Hydrogen	132-140	H1.5 linker histone, cluster member	Homo sapiens	49-55
23862489-4	2013	A dry oxidation process using only oxygen without hydrogen and oxidation for logic gates led to the formation of a sacrificial oxide on the rapid thermal oxidation (RTP) methods without densification after gap-filling as reducing dislocation processes.	Hydrogen	50-58	MORN repeat containing 4	Homo sapiens	165-168
28482263-4	2017	Molecular docking studies showed that compound 4j have high binding affinities with the active site of alpha-glucosidase enzyme through hydrogen bonds, arene-cation, pi-pi stacking and hydrophobic interactions.	Hydrogen	136-144	sucrase-isomaltase	Homo sapiens	103-120
28195409-1	2017	Isolable dialkylsilylene 5 reacts with dihydrogen in the presence of a small amount of a conventional Lewis acid (BPh3 , BEt3 ) or a base (PPh3 , PEt3 , NPh3 , NEt3 ) at low temperatures in a hydrocarbon solvent, giving the corresponding dihydrosilane 10 in high yields.	Hydrogen	39-49	trafficking protein particle complex subunit 3	Homo sapiens	121-125
28302724-2	2017	Significant positive-charge localization on one of the Chl constituents, PD1 or PD2, in P680+ has been proposed to contribute to this high Em To identify the Chl molecule on which the charge is mainly localized, we genetically introduced a hydrogen bond to the 131-keto C=O group of PD1 and PD2 by changing the nearby D1-Val-157 and D2-Val-156 residues to His, respectively.	Hydrogen	240-248	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	80-83
23708094-4	2013	Turn9-6 and four hydrogen bonds (HB9-6, HB6-9, HB11-4 and HB4-11) are formed at physiological pH; turn8-5 and five hydrogen bonds (HB8-5, HB5-8, HB10-3, HB3-10 and HB12-1) are formed at acidic pH.	Hydrogen	17-25	keratin 86	Homo sapiens	40-45
28302724-2	2017	Significant positive-charge localization on one of the Chl constituents, PD1 or PD2, in P680+ has been proposed to contribute to this high Em To identify the Chl molecule on which the charge is mainly localized, we genetically introduced a hydrogen bond to the 131-keto C=O group of PD1 and PD2 by changing the nearby D1-Val-157 and D2-Val-156 residues to His, respectively.	Hydrogen	240-248	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	291-294
3436705-3	1987	In the presence of triethylamine, H-4 of the latter migrates to C-2 accompanied by a shift of the double bond to give 4-alkyl-5(2H)-oxazolones which show 5J coupling between H2-2 and 4-CCHn protons.	Hydrogen	174-176	complement C2	Homo sapiens	64-67
28302724-3	2017	Successful hydrogen bond formation at PD1 and PD2 in the obtained D1-V157H and D2-V156H mutants, respectively, was monitored by detecting 131-keto C=O vibrations in Fourier transfer infrared (FTIR) difference spectra upon oxidation of P680 and the symmetrically located redox-active tyrosines YZ and YD, and they were simulated by quantum-chemical calculations.	Hydrogen	11-19	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	46-49
28496315-9	2017	RESULTS: The results showed that hydrogen inhalation significantly reduced the number of inflammatory cells in the bronchoalveolar lavage fluid, and the mRNA and protein expression levels of tumor necrosis factor alpha, IL-6, IL-17, IL-23, matrix metalloproteinase-12, caspase-3, and caspase-8, but increased the tissue inhibitor of metalloproteinase-1 expression.	Hydrogen	33-41	interleukin 17A	Rattus norvegicus	226-231
28325601-4	2017	Three key hydrogen bonding interactions were found in the docking of 13h with PI3Kdelta enzyme.	Hydrogen	10-18	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	78-87
23487259-0	2013	Hydrogen bonded anion ribbons, networks and clusters and sulfur-anion interactions in novel radical cation salts of BEDT-TTF with sulfamate, pentaborate and bromide.	Hydrogen	0-8	ras homolog family member H	Homo sapiens	121-124
23487259-4	2013	In contrast, the BEDT-TTF salt with pentaborate contains infinite layers formed of a network of hydrogen bonded pentaborate anions.	Hydrogen	96-104	ras homolog family member H	Homo sapiens	22-25
23487259-5	2013	Two new bromide salts of BEDT-TTF are reported, one is a semiconducting 1 : 1 salt in which the bromide is integrated among the BEDT-TTF donors, while the other contain a square of four bromide ions linked together by hydrogen bonding to a centrally located H5O2(+) cation for every five BEDT-TTF molecules.	Hydrogen	218-226	ras homolog family member H	Homo sapiens	30-33
23388512-13	2013	Hydrogen treatment diminished phosphorylation of Lyn kinase and release of tryptase, decreased accumulation and degranulation of mast cells, attenuated blood-brain barrier disruption, and improved neurobehavioral function.	Hydrogen	0-8	tryptase alpha/beta 1	Mus musculus	75-83
2959956-6	1987	From these and earlier results, we propose a possible mechanism in which the carbon-centered radical formed at C-5" by hydrogen atom abstraction by thiol-activated NCS-Chrom reacts anaerobically with misonidazole to form a nitroxyl-radical-adduct intermediate, which fragments to produce an oxy radical at C-5".	Hydrogen	119-127	complement C5	Homo sapiens	111-114
23420844-3	2013	Homology modeling of mGluR8 transmembrane domain with rhodopsin as a template suggested the presence of a conserved water-mediated hydrogen-bonding network between helices VI and VII, which presumably constrains the receptor in an inactive conformation.	Hydrogen	131-139	glutamate receptor, metabotropic 8	Mus musculus	21-27
28145082-0	2017	Revealing the physical nature and the strength of charge-inverted hydrogen bonds by SAPT(DFT), MP2, SCS-MP2, MP2C, and CCSD(T) methods.	Hydrogen	66-74	tryptase pseudogene 1	Homo sapiens	95-98
28145082-0	2017	Revealing the physical nature and the strength of charge-inverted hydrogen bonds by SAPT(DFT), MP2, SCS-MP2, MP2C, and CCSD(T) methods.	Hydrogen	66-74	tryptase pseudogene 1	Homo sapiens	104-107
28145082-1	2017	The physical nature of charge-inverted hydrogen bonds in H3 XH  YH3 (X = Si, Ge; Y = Al, Ga) dimer systems is studied by means of the SAPT(DFT)-based decomposition of interaction energies and supermolecular interaction energies based on MP2, SCS-MP2, MP2C, and CCSD(T) methods utilizing dimer-centered aug-cc-pCVnZ (n = D, T, Q) basis sets as well as an extrapolation to the complete basis set limit.	Hydrogen	39-47	tryptase pseudogene 1	Homo sapiens	237-240
28145082-1	2017	The physical nature of charge-inverted hydrogen bonds in H3 XH  YH3 (X = Si, Ge; Y = Al, Ga) dimer systems is studied by means of the SAPT(DFT)-based decomposition of interaction energies and supermolecular interaction energies based on MP2, SCS-MP2, MP2C, and CCSD(T) methods utilizing dimer-centered aug-cc-pCVnZ (n = D, T, Q) basis sets as well as an extrapolation to the complete basis set limit.	Hydrogen	39-47	tryptase pseudogene 1	Homo sapiens	246-249
2959956-6	1987	From these and earlier results, we propose a possible mechanism in which the carbon-centered radical formed at C-5" by hydrogen atom abstraction by thiol-activated NCS-Chrom reacts anaerobically with misonidazole to form a nitroxyl-radical-adduct intermediate, which fragments to produce an oxy radical at C-5".	Hydrogen	119-127	complement C5	Homo sapiens	306-309
23519668-5	2013	The N atom in the azaalkyl chain of DAAM-3 is located at almost the same position as the N-methyl C atom of the methylated lysine side chain in the substrate-peptide complex structures and stabilizes complex formation by hydrogen bonding to the substrate-binding site residues of SET7/9.	Hydrogen	221-229	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	280-286
3624221-5	1987	The 1H and 13C nuclear magnetic resonance data indicated that imidazole C-2 of histidine is linked to C-6 of norleucine (epsilon-deaminated lysine residue) which in turn is linked to the C-6 amino group of hydroxylysine.	Hydrogen	4-6	complement C6	Bos taurus	102-105
23514171-2	2013	These numbers are encoded in the free energy of the Hermitian matrix model with potential V(x)=x2/2-stx/(1-tx), where s and t are respective generating parameters for the number of RNA molecules and hydrogen bonds in a given complex.	Hydrogen	199-207	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	100-103
3624221-5	1987	The 1H and 13C nuclear magnetic resonance data indicated that imidazole C-2 of histidine is linked to C-6 of norleucine (epsilon-deaminated lysine residue) which in turn is linked to the C-6 amino group of hydroxylysine.	Hydrogen	4-6	complement C6	Bos taurus	187-190
23344796-13	2013	Pharmacophore mapping revealed a prohibitive hydrogen bond donor group in noninhibitors adjacent to a hydrophobic moiety that was important for binding to Oat3.	Hydrogen	45-53	solute carrier family 22 member 8	Homo sapiens	155-159
3124848-6	1987	Therefore, these results indicate that: 1) ADPRT inhibiting activity is inverse function of dipole moments, hydrogen bonding strength and steric hindrance of the amide functional group and 2) substitution of benzene with thiophene results in a substantial reduction of the enzyme inhibiting activity.	Hydrogen	108-116	poly [ADP-ribose] polymerase 1	Cricetulus griseus	43-48
23511424-4	2013	The conversion of a MeOH-H2O mixture proceeds selectively to CO2/H2 gas formation under neutral conditions, thereby allowing the use of the entire hydrogen content (12% by weight).	Hydrogen	147-155	complement C2	Homo sapiens	61-67
23392615-2	2013	When incorporated into peptide sequences (Xaa-(S)Ant-Yaa), this rigid aromatic beta-amino acid strongly imparts a reverse-turn conformation to the peptide backbone, featuring robust 11-membered-ring hydrogen-bonding.	Hydrogen	199-207	solute carrier family 25 member 6	Homo sapiens	49-52
3117106-3	1987	In both cases, the C-C bond formation was found to take place at the si face of the double bond with elimination of one of the hydrogens of C-2 in a syn fashion.	Hydrogen	127-136	complement C2	Homo sapiens	140-143
23401172-8	2013	The resulting ionic system reacts readily with H2 to give cationic species [8,8,8-(H)(PPh3 )2 -9-(Py)-nido-8,7-RhSB9 H9 ](+) (7).	Hydrogen	47-49	protein phosphatase 4 catalytic subunit	Homo sapiens	86-90
23291196-4	2013	The FTIR results showed that the strong intermolecular hydrogen bonds took place between CS, Ny6 and PUF.	Hydrogen	55-63	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	101-104
3549306-7	1987	This was shown by covalently labelling the Cys-374 residue of actin with a spin-label and observing the enhanced relaxation this paramagnetic centre induced in the 1H-NMR spectrum of S1(A1).	Hydrogen	164-166	actin	Oryctolagus cuniculus	62-67
23210831-0	2013	Conformational preferences of cis-1,3-cyclopentanedicarboxylic acid and its salts by 1H NMR spectroscopy: energetics of intramolecular hydrogen bonds in DMSO.	Hydrogen	85-87	suppressor of cytokine signaling 1	Homo sapiens	30-35
23210831-0	2013	Conformational preferences of cis-1,3-cyclopentanedicarboxylic acid and its salts by 1H NMR spectroscopy: energetics of intramolecular hydrogen bonds in DMSO.	Hydrogen	135-143	suppressor of cytokine signaling 1	Homo sapiens	30-35
23210831-7	2013	The calculated intramolecular hydrogen bond strength of 1A was ~3.1 kcal mol(-1), which is ~2.7 kcal mol(-1) more stable than the values for cis-1,3-cyclohexanedicarboxylic acid (2A).	Hydrogen	30-38	suppressor of cytokine signaling 1	Homo sapiens	141-146
3830182-1	1987	The primary structure of Klebsiella serotype K10 capsular polysaccharide has been investigated using mainly the techniques of methylation, partial hydrolysis, and 1H and 13C NMR spectroscopy.	Hydrogen	163-165	keratin 10	Homo sapiens	45-48
27481520-7	2013	Besides the hydrogen bond formation, the van der Waals interactions between residues Ile10, Val18, and Leu133 of CDK5 and inhibitors were discovered to constitute another substantial component of their binding mode.	Hydrogen	12-20	cyclin dependent kinase 5	Homo sapiens	113-117
23439552-6	2013	The results of the MP2 ab initio calculations reveal enolimine including an intramolecular OH...N hydrogen bond to be the most stable form both with electron-donor and electron-acceptor substituents.	Hydrogen	98-106	tryptase pseudogene 1	Homo sapiens	19-22
3612809-8	1987	data indicate that histidines 24 (B5) and 119 (GH1) are hydrogen bonded to each other and, in contrast to neutron diffraction data, show that His24 does not protonate at pH greater than 5.	Hydrogen	56-64	somatotropin	Physeter catodon	47-50
23382199-6	2013	Together with this finding, the crystal structural analysis of OxdA and spectroscopic and electrostatic potential analyses of the wild-type and mutant OxdAs suggest that S219 plays a key role in the catalysis, forming a hydrogen bond with the substrate.	Hydrogen	220-228	D-amino acid oxidase	Homo sapiens	63-67
3816786-2	1987	To reveal non-covalent interactions between the Fab and Fc regions of IgG molecules the average conformational free-energy change (delta Go), associated with reversible micro-unfoldings, was measured by hydrogen-deuterium exchange for the Fab and Fc fragments and the complete molecule.	Hydrogen	203-211	FA complementation group B	Homo sapiens	48-51
22676305-8	2013	A change of the Lewis basicity of the anion was estimated using (1)H NMR spectroscopy, by comparison of the measured chemical shifts of the C-2 hydrogen in the imidazolium ring.	Hydrogen	144-152	complement C2	Homo sapiens	140-143
22671581-3	2013	However, HCN can form hydrogen bonds with the hydrogen atoms of the benzene cation (CH(delta+)   NCH) and linear hydrogen bonding chains involving HCN   HCN interaction.	Hydrogen	46-54	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	9-12
3816786-9	1987	The pH dependence of the hydrogen-deuterium exchange also indicates interactions between the Fab and Fc regions.	Hydrogen	25-33	FA complementation group B	Homo sapiens	93-96
22671581-3	2013	However, HCN can form hydrogen bonds with the hydrogen atoms of the benzene cation (CH(delta+)   NCH) and linear hydrogen bonding chains involving HCN   HCN interaction.	Hydrogen	46-54	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	147-150
22671581-3	2013	However, HCN can form hydrogen bonds with the hydrogen atoms of the benzene cation (CH(delta+)   NCH) and linear hydrogen bonding chains involving HCN   HCN interaction.	Hydrogen	46-54	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	147-150
3267288-3	1987	Blood flow in the anterior pituitary (PBF) was measured using the hydrogen clearance method.	Hydrogen	66-74	PTTG1 interacting protein	Rattus norvegicus	38-41
22671581-3	2013	However, HCN can form hydrogen bonds with the hydrogen atoms of the benzene cation (CH(delta+)   NCH) and linear hydrogen bonding chains involving HCN   HCN interaction.	Hydrogen	46-54	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	9-12
22671581-3	2013	However, HCN can form hydrogen bonds with the hydrogen atoms of the benzene cation (CH(delta+)   NCH) and linear hydrogen bonding chains involving HCN   HCN interaction.	Hydrogen	46-54	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	147-150
22671581-3	2013	However, HCN can form hydrogen bonds with the hydrogen atoms of the benzene cation (CH(delta+)   NCH) and linear hydrogen bonding chains involving HCN   HCN interaction.	Hydrogen	46-54	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	147-150
22671581-4	2013	HCN molecules tend to form externally solvated structures with the benzene cation where the ion is hydrogen bonded to the exterior of HCN chains.	Hydrogen	99-107	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-3
3790573-0	1986	1H-NMR assignments and the dynamics of interconversion of the isomeric forms of cytochrome b5 in solution.	Hydrogen	0-2	cytochrome b5 type A	Homo sapiens	80-93
23434661-3	2013	The results demonstrate that the CMCS/PEI blend is miscible, due to the hydrogen bonding interaction between the two targeted polymers.	Hydrogen	72-80	G protein signaling modulator 2	Homo sapiens	33-37
3021640-2	1986	In the monoclinic form, the radical arises by the loss of a hydrogen atom from the carbon atom C(2), whereas, in the orthorhombic form, it arises by addition of a hydrogen atom to the oxygen atom O(3).	Hydrogen	60-68	complement C2	Homo sapiens	95-99
23036849-0	2013	Accurate classification of childhood brain tumours by in vivo 1H MRS - a multi-centre study.	Hydrogen	62-64	solute carrier family 9 member A6	Homo sapiens	65-72
3782178-3	1986	With increasing hydrogen-bonding character of M-PAEUU, the adsorbed bovine serum albumin (BSA) was more denatured.	Hydrogen	16-24	albumin	Bos taurus	75-88
23442851-3	2013	The P-selectin/PSGL-1 binding is strengthened at acidic pH, as evidenced by the formation of a new hydrogen bond (seen computationally) and the observed decrease in the rolling velocities of model cells.	Hydrogen	99-107	selectin P	Homo sapiens	4-14
23442851-3	2013	The P-selectin/PSGL-1 binding is strengthened at acidic pH, as evidenced by the formation of a new hydrogen bond (seen computationally) and the observed decrease in the rolling velocities of model cells.	Hydrogen	99-107	selectin P ligand	Homo sapiens	15-21
3017760-0	1986	A high resolution 1H NMR study of the solution structure of human epidermal growth factor.	Hydrogen	18-20	epidermal growth factor	Homo sapiens	66-89
23201405-4	2013	MiR-126 expression was increased 1.7-fold (p&lt;0.05) after 1h of hypoxic exposure and this was further enhanced to 3.0-fold (p&lt;0.01) by simultaneously blocking HDAC with the pan-HDAC inhibitor Tricostatin A (TSA).	Hydrogen	60-62	microRNA 126	Homo sapiens	0-7
3017760-1	1986	500 MHz 1H NMR studies of human epidermal growth factor are described.	Hydrogen	8-10	epidermal growth factor	Homo sapiens	32-55
3800936-19	1986	Its mechanism of formation probably involves hydrogen atom abstraction by .OH radicals from the C-5" of the 2"-deoxyguanosine moiety followed by intramolecular cyclization with the formation of a covalent bond between the C-5" and C-8 and subsequent oxidation of the resulting N-7-centred radical.	Hydrogen	45-53	complement C5	Homo sapiens	96-99
23332074-8	2013	We also show that, in addition to tight intermolecular hydrophobic interactions between CypA and the substrate, an intricate enzyme-substrate intermolecular hydrogen-bonding network is extremely sensitive to the configuration of the substrate.	Hydrogen	157-165	peptidylprolyl isomerase A	Homo sapiens	88-92
3800936-19	1986	Its mechanism of formation probably involves hydrogen atom abstraction by .OH radicals from the C-5" of the 2"-deoxyguanosine moiety followed by intramolecular cyclization with the formation of a covalent bond between the C-5" and C-8 and subsequent oxidation of the resulting N-7-centred radical.	Hydrogen	45-53	complement C5	Homo sapiens	222-225
23275167-8	2013	Additionally, the various hydrogen bonds formed between the AHNAK peptide and (p11)(2)(AnxA2)(2) most often involve backbone atoms of AHNAK; as a result, the side chains, particularly those that point away from S100A10/AnxA2 towards the solvent, are largely interchangeable.	Hydrogen	26-34	annexin A2	Homo sapiens	87-92
23275167-8	2013	Additionally, the various hydrogen bonds formed between the AHNAK peptide and (p11)(2)(AnxA2)(2) most often involve backbone atoms of AHNAK; as a result, the side chains, particularly those that point away from S100A10/AnxA2 towards the solvent, are largely interchangeable.	Hydrogen	26-34	annexin A2	Homo sapiens	219-224
28197581-8	2017	In situ characterisation in the magnetometer revealed that the Co3O4 crystallites are partially reduced to metallic Co above 225  C with crystallites larger than 7.5 nm showing higher degrees of reduction under the H2-rich environment of CO-PrOx.	Hydrogen	215-217	pyruvate dehydrogenase complex component X	Homo sapiens	241-245
3733689-1	1986	The mechanism of the denitrification and nitrosation reactions catalyzed by the heme cd-containing nitrite reductase from Pseudomonas stutzeri JM 300 has been studied with whole cell suspensions using H2(18)O, 15NO, and 15NO-2.	Hydrogen	201-203	nitrite reductase small subunit NirD	Pseudomonas stutzeri	99-116
23775688-7	2013	The driving force of the insertion process is the formation of a transient OH-Pi hydrogen bond between the ganglioside and the aromatic ring of the alpha-synuclein residue Tyr-39.	Hydrogen	81-89	synuclein alpha	Homo sapiens	148-163
24148794-10	2013	Furthermore, H2 treatment could also dose-dependently increase the HO-1 protein expression and activity at 3 h, 6 h, 12 h and 24 h in LPS-activated macrophages.	Hydrogen	13-15	heme oxygenase 1	Homo sapiens	67-71
24148794-11	2013	In addition, blockade of HO-1 activity with ZnPP-IX partly reversed the anti-inflammatory effect of H2 in LPS-stimulated macrophages.	Hydrogen	100-102	heme oxygenase 1	Homo sapiens	25-29
24148794-12	2013	CONCLUSIONS: Molecular hydrogen exerts a regulating role in the release of pro- and anti-inflammatory cytokines in LPS-stimulated macrophages, and this effect is at least partly mediated by HO-1 expression and activation.	Hydrogen	23-31	heme oxygenase 1	Homo sapiens	190-194
2424790-1	1986	1H-NMR spectroscopy has been applied to identify components in the urine of subjects with a deficiency of the enzyme 3-hydroxy-3-methylglutaryl-CoA lyase.	Hydrogen	0-2	3-hydroxy-3-methylglutaryl-CoA lyase	Homo sapiens	117-153
22890747-1	2013	MP2(full)/aug-cc-pVDZ(-PP) computations predict that new triangular bonding complexes CBr4...X-...H-C (where X- is a halide and H-C refers to a protic solvent molecule) consist of one halogen bond and two hydrogen bonds in the gas phase.	Hydrogen	205-213	carbonyl reductase 4	Homo sapiens	86-90
28425975-4	2017	Molecular docking studies revealed the existence of hydrophobic interaction, CH-pi interaction, arene-anion interaction, arene-cation interaction, and hydrogen bond between these compounds and alpha-glucosidase enzyme.	Hydrogen	151-159	sucrase-isomaltase	Homo sapiens	193-210
28355055-6	2017	Interestingly, in terms of catalysis NiPS3, CoPS3, and BiPS4 show the highest efficiency for hydrogen evolution reaction (HER), while for the oxygen evolution reaction (OER) the highest performance is observed for CoPS3.	Hydrogen	93-101	COP9 signalosome subunit 3	Homo sapiens	44-49
28355055-6	2017	Interestingly, in terms of catalysis NiPS3, CoPS3, and BiPS4 show the highest efficiency for hydrogen evolution reaction (HER), while for the oxygen evolution reaction (OER) the highest performance is observed for CoPS3.	Hydrogen	93-101	COP9 signalosome subunit 3	Homo sapiens	214-219
3754465-0	1986	The effect of bulk hydrogen ion concentration upon the apparent kinetic parameters of purified pig liver catechol O-methyltransferase.	Hydrogen	19-27	catechol-O-methyltransferase	Sus scrofa	105-133
24168111-5	2013	Screening of natural and new lupulone derivatives for their anticancer activity demonstrated that one (lupulone derivative 1h) displayed stronger anticancer activity than lupulone itself on PC3 and DU145 prostate cancer cells.	Hydrogen	123-125	chromobox 8	Homo sapiens	190-193
28349153-2	2017	In this Article, we report that an Al-doped CoP nanoarray on carbon cloth (Al-CoP/CC) behaves as a durable hydrogen evolution electrocatalyst with superhigh activity in 0.5 M H2SO4.	Hydrogen	107-115	caspase recruitment domain family member 16	Homo sapiens	44-47
3007460-10	1986	The second-order rate constant for inactivation of dopamine beta-hydroxylase by benzylhydrazine in the presence of ascorbate is increased about 4-fold when the benzylic hydrogens are replaced with deuterium.	Hydrogen	169-178	dopamine beta-hydroxylase	Homo sapiens	51-76
28349153-2	2017	In this Article, we report that an Al-doped CoP nanoarray on carbon cloth (Al-CoP/CC) behaves as a durable hydrogen evolution electrocatalyst with superhigh activity in 0.5 M H2SO4.	Hydrogen	107-115	caspase recruitment domain family member 16	Homo sapiens	78-81
28349153-4	2017	Density functional theory calculations reveal that Al-CoP has a more thermo-neutral hydrogen adsorption free energy than CoP.	Hydrogen	84-92	caspase recruitment domain family member 16	Homo sapiens	54-57
23382805-6	2013	The molecular docking and dynamics simulations results revealed that the hydrogen bonds between Arg97 and Gln167 are crucial to inhibit the function of SIRT2.	Hydrogen	73-81	sirtuin 2	Homo sapiens	152-157
23383101-8	2013	15N-1H HSQC NMR experiments reveal interactions of the alpha4 CT C-terminal region with a fragment of paxillin (residues G139-K277) that encompassed LD2-LD4 repeats.	Hydrogen	4-6	paxillin	Homo sapiens	102-110
27704363-0	2017	Backbone 1H, 15N, and 13C resonance assignments of the Tom1 VHS domain.	Hydrogen	9-11	target of myb1 membrane trafficking protein	Homo sapiens	55-59
3949781-2	1986	Infrared spectroscopy in the interval from 1800 to 1300 cm-1 has been used to investigate the secondary structure and the hydrogen/deuterium exchange behavior of bacteriorhodopsin and bovine rhodopsin in their respective native membranes.	Hydrogen	122-130	rhodopsin	Bos taurus	170-179
27704363-5	2017	Here, we report the nearly complete 1H, 15N, and 13C backbone resonance assignments of the VHS domain of human Tom1.	Hydrogen	36-38	target of myb1 membrane trafficking protein	Homo sapiens	111-115
26605619-5	2012	The hydrogen abstraction from camphor, and hydrogen abstraction and C-O addition of cyclohexene and propene by P450cam have been modeled, along with the addition of benzene to Compound I in CYP2C9, at the B3LYP-D2/CHARMM27 level of theory.	Hydrogen	4-12	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	190-196
26605619-5	2012	The hydrogen abstraction from camphor, and hydrogen abstraction and C-O addition of cyclohexene and propene by P450cam have been modeled, along with the addition of benzene to Compound I in CYP2C9, at the B3LYP-D2/CHARMM27 level of theory.	Hydrogen	43-51	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	190-196
3949781-7	1986	Peptide hydrogen exchange of bacteriorhodopsin and rhodopsin was monitored by observing the change in the ratio of integrated absorbance (Aamide II"/Aamide I") during the interval from 1.5 to 25 h after membranes were introduced into buffered D2O.	Hydrogen	8-16	rhodopsin	Bos taurus	37-46
22984865-2	2012	Herein, we describe the discovery of a novel class of BACE-1 inhibitors represented by sulfamide 14g, using a medicinal chemistry strategy to optimize central nervous system (CNS) penetration by minimizing hydrogen bond donors (HBDs) and reducing P-glycoprotein (P-gp) mediated efflux.	Hydrogen	206-214	beta-site APP cleaving enzyme 1	Mus musculus	54-60
3877065-1	1985	This work describes the determination of CBF in eight normal human subjects with positron emission tomographic (PET) imaging using the continuous intravenous infusion of H2(15)O.	Hydrogen	170-172	CCAAT enhancer binding protein zeta	Homo sapiens	41-44
22973893-6	2012	Computational analyses revealed that inhibitors and noninhibitors can be differentiated from each other on the basis of several physicochemical features, including number of hydrogen-bond donors, number of rotatable bonds, and topological polar surface area (TPSA) for hOAT1; and molecular weight, number of hydrogen-bond donors and acceptors, TPSA, partition coefficient (log P(7.4)), and polarizability for hOAT3.	Hydrogen	308-316	solute carrier family 22 member 6	Homo sapiens	269-274
22973893-7	2012	Pharmacophore modeling identified two common structural features associated with inhibitors for hOAT1 and hOAT3, viz., an anionic hydrogen-bond acceptor atom, and an aromatic center separated by ~5.7 A.	Hydrogen	130-138	solute carrier family 22 member 6	Homo sapiens	96-101
22973893-7	2012	Pharmacophore modeling identified two common structural features associated with inhibitors for hOAT1 and hOAT3, viz., an anionic hydrogen-bond acceptor atom, and an aromatic center separated by ~5.7 A.	Hydrogen	130-138	solute carrier family 22 member 8	Homo sapiens	106-111
22801419-5	2012	The estimated thermodynamic parameters suggest that the main intermolecular interaction is hydrophobic association, although hydrogen bonds between flavonoids and the active gorge of the acetylcholinesterase molecule seem to occur and have a great impact on acetylcholinesterase inhibition.	Hydrogen	125-133	acetylcholinesterase	Rattus norvegicus	187-207
22801419-7	2012	FTIR analysis showed that the plant extract components do not interfere with the secondary structure of the enzyme, but decreases the rate of hydrogen-deuterium exchange, possibly by decreasing solvent accessibility in the acetylcholinesterase active gorge.	Hydrogen	142-150	acetylcholinesterase	Rattus norvegicus	223-243
22985069-5	2012	This hydrogen bond may account for the 860-fold selectivity of 28 against PDE1B, in comparison with about 30-fold selectivity of BAY73-6691.	Hydrogen	5-13	phosphodiesterase 1B	Homo sapiens	74-79
2997192-0	1985	7Li, 31P, and 1H NMR studies of interactions between ATP, monovalent cations, and divalent cation sites on rabbit muscle pyruvate kinase.	Hydrogen	14-16	pyruvate kinase PKLR	Oryctolagus cuniculus	121-136
22676917-5	2012	The general degradation behaviour of Nd2 in a 0.9% NaCl solution was investigated by means of polarization curves and hydrogen evolution.	Hydrogen	118-126	NADH dehydrogenase 2, mitochondrial	Mus musculus	37-40
4054123-5	1985	In addition, hydrogen bonds exist between the N(1) and N(3) atoms of FMN and the apoprotein.	Hydrogen	13-21	formin 1	Homo sapiens	69-72
21915608-0	2012	1H, 13C and 15N resonance assignments of the GTPase-activating (GAP) and Ral binding domains (GBD) of RLIP76 (RalBP1).	Hydrogen	0-2	ralA binding protein 1	Homo sapiens	102-108
21915608-0	2012	1H, 13C and 15N resonance assignments of the GTPase-activating (GAP) and Ral binding domains (GBD) of RLIP76 (RalBP1).	Hydrogen	0-2	ralA binding protein 1	Homo sapiens	110-116
4054124-5	1985	A strong deshielding of the C(2) and C(4) atoms of enzyme-bound FMN both in the oxidized and reduced state is observed, which is supposed to be induced by hydrogen-bond formation between the protein and the two carbonyl groups at C(2) and C(4) of the isoalloxazine ring system.	Hydrogen	155-163	formin 1	Homo sapiens	64-67
3878727-0	1985	1H, 113Cd, and 31P NMR of osteocalcin (bovine gamma-carboxyglutamic acid containing protein).	Hydrogen	0-2	bone gamma-carboxyglutamate protein	Bos taurus	26-37
22947039-7	2012	Hcp2 enhanced the rate of nitrite reduction when, in addition to lactate, hydrogen was also present as an electron donor.	Hydrogen	74-82	CYCS pseudogene 52	Homo sapiens	0-4
4045922-5	1985	Four members of the series were more potent that the N10-hydrogen compound, but none was superior to the previously described N10-propargyl-5,8-dideazafolic acid.	Hydrogen	57-65	nuclear receptor subfamily 4, group A, member 1	Mus musculus	53-56
22742936-5	2012	The results showed that hydrogen-rich saline reduced the level of malondialdehyde (MDA) and elevated the level of silent information regulator 2 (Sir2).	Hydrogen	24-32	sirtuin 2	Homo sapiens	114-144
22742936-5	2012	The results showed that hydrogen-rich saline reduced the level of malondialdehyde (MDA) and elevated the level of silent information regulator 2 (Sir2).	Hydrogen	24-32	sirtuin 2	Homo sapiens	146-150
2414863-5	1985	Hydrogen bonding at the C-12 position is probably an important means of binding of STX to the membrane receptor site.	Hydrogen	0-8	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	83-86
22583846-3	2012	The results indicated that hydrogen bonds and electrostatic interaction between HA and SP molecules play an important role in the formation of HA-SPC.	Hydrogen	27-35	pulmonary surfactant-associated protein C	Oryctolagus cuniculus	146-149
2418538-5	1985	The results suggest that hydrogen bonding at C-4 and C-9 is an important contributing force in binding to the membrane receptor site.	Hydrogen	25-33	complement C4A (Rodgers blood group)	Homo sapiens	45-56
6514011-4	1984	Replacement of the para-hydrogen atom in the mexiletine aromatic ring by bromine increased potency towards both MAO-A and SSAO.	Hydrogen	24-32	amine oxidase, copper containing 3	Rattus norvegicus	122-126
22849590-1	2012	Dihydrogenated boron clusters, H(2)B(n)(-) (n = 7-12), were produced and characterized using photoelectron spectroscopy and computational chemistry to have ladderlike structures terminated by a hydrogen atom on each end.	Hydrogen	2-10	H2B clustered histone 21	Homo sapiens	31-36
6514011-5	1984	Replacement of the ortho-methyl group in the mexiletine aromatic ring by hydrogen increased the potency towards SSAO alone.	Hydrogen	73-81	amine oxidase, copper containing 3	Rattus norvegicus	112-116
22587986-10	2012	The most important molecular descriptors for the prediction of OATP1B1 inhibition were maximal hydrogen bonding strength followed by cLogP.	Hydrogen	95-103	solute carrier organic anion transporter family member 1B1	Homo sapiens	63-70
6593701-3	1984	Assignments can be made from the H1 and H2 protons to their J-coupled neighbors (H2 and H3) within this main envelope by using 1H-1H correlated spectroscopy.	Hydrogen	127-129	H1.5 linker histone, cluster member	Homo sapiens	33-42
22788777-6	2012	Based on distance geometry method and intermolecular hydrogen bonding analysis, the key functional domain in DR5 was predicted and the DR5 mutants were designed.	Hydrogen	53-61	TNF receptor superfamily member 10b	Homo sapiens	109-112
6593701-3	1984	Assignments can be made from the H1 and H2 protons to their J-coupled neighbors (H2 and H3) within this main envelope by using 1H-1H correlated spectroscopy.	Hydrogen	130-132	H1.5 linker histone, cluster member	Homo sapiens	33-42
22788777-6	2012	Based on distance geometry method and intermolecular hydrogen bonding analysis, the key functional domain in DR5 was predicted and the DR5 mutants were designed.	Hydrogen	53-61	TNF receptor superfamily member 10b	Homo sapiens	135-138
6333250-10	1984	Nuclear Overhauser methods, used to differentiate direct (protonation) and indirect (conformation) effects on the chemical shift changes in the spectra of mEGF by varying the pH, yield evidence for a pH-induced conformational transition in the protein hormone associated with the breaking of the His-22 salt bridge or hydrogen bond.	Hydrogen	318-326	epidermal growth factor	Mus musculus	155-159
22573553-6	2012	The V-ATPase activity and extracellular hydrogen ion concentration were significantly increased in 2B4 cells transfected with the LASS2/TMSG1-siRNA compared with the controls.	Hydrogen	40-48	ceramide synthase 2	Homo sapiens	130-135
22573553-6	2012	The V-ATPase activity and extracellular hydrogen ion concentration were significantly increased in 2B4 cells transfected with the LASS2/TMSG1-siRNA compared with the controls.	Hydrogen	40-48	ceramide synthase 2	Homo sapiens	136-141
22573553-8	2012	Thus, we concluded that silencing of LASS2/TMSG1 may promote invasion of prostate cancer cell in vitro through increase of V-ATPase activity and extracellular hydrogen ion concentration and in turn the activation of secreted MMP-2.	Hydrogen	159-167	ceramide synthase 2	Homo sapiens	37-42
22573553-8	2012	Thus, we concluded that silencing of LASS2/TMSG1 may promote invasion of prostate cancer cell in vitro through increase of V-ATPase activity and extracellular hydrogen ion concentration and in turn the activation of secreted MMP-2.	Hydrogen	159-167	ceramide synthase 2	Homo sapiens	43-48
23004294-3	2012	Our results show that H2 molecules are dissociated on the Au tip; the adsorbed H atoms change the density of states at the Fermi level (E(F)) of the tip, increasing its p-orbital character and reducing the s-orbital contribution.	Hydrogen	22-24	TOR signaling pathway regulator	Homo sapiens	61-64
6722137-10	1984	The source of all 28 prochiral hydrogens of the palmitic acid synthesized by chicken liver fatty acid synthase was inferred from the results of this work.	Hydrogen	31-40	fatty acid synthase	Gallus gallus	91-110
23004294-3	2012	Our results show that H2 molecules are dissociated on the Au tip; the adsorbed H atoms change the density of states at the Fermi level (E(F)) of the tip, increasing its p-orbital character and reducing the s-orbital contribution.	Hydrogen	22-24	TOR signaling pathway regulator	Homo sapiens	149-152
22562405-0	2012	Rational design of hyperbranched 3D heteroarrays of SrS/CdS: synthesis, characterization and evaluation of photocatalytic properties for efficient hydrogen generation and organic dye degradation.	Hydrogen	147-155	CDP-diacylglycerol synthase 1	Homo sapiens	56-59
22562405-3	2012	The prepared 3D SrS/CdS exhibited improved photocatalytic activity for water splitting leading to H(2) generation (AQY 10%) and nearly complete degradation of methyl orange (MO) dye.	Hydrogen	98-102	CDP-diacylglycerol synthase 1	Homo sapiens	20-23
6312054-1	1983	Hydrogen-exchange studies locate a set of seven allosterically sensitive amide NH protons side by side around two turns of the F-FG helical segment in the hemoglobin beta chain.	Hydrogen	0-8	hemoglobin subunit beta	Homo sapiens	155-170
22120948-3	2012	The best hypothesis (Hypo1(SGLT2)) contains one hydrogen bond donor, five excluded volumes, one ring aromatic and three hydrophobic features, and has a correlation coefficient of 0.955, cost difference of 68.76, RMSD of 0.85.	Hydrogen	48-56	solute carrier family 5 member 2	Homo sapiens	27-32
22587664-6	2012	In contrast, the upregulated level of MDA, caspase-12/3 and brain edema was attenuated and the brain injury was substantially alleviated in the hydrogen treated rabbits, but the improvement of neurology outcome was not obvious.	Hydrogen	144-152	LOW QUALITY PROTEIN: caspase-12	Oryctolagus cuniculus	43-53
28163272-1	2017	A novel type of molecularly imprinted polymer (MIP), N-benzoyl-(S)-valine anilide-imprinted polymer (IP-2), was prepared using hydrogen-bonding interactions as a main force in the pre-polymerization step.	Hydrogen	127-135	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	101-105
28151577-3	2017	Thus, the achieved significantly increased photocatalytic H2 -evolution rate on the optimized CoP/TiO2 (8350 micromol h-1 g-1 ) is 11 times higher than that of the pristine TiO2 .	Hydrogen	58-60	caspase recruitment domain family member 16	Homo sapiens	94-97
6643431-3	1983	They all catalyzed the specific elimination of the pro-R hydrogen at C-2 of isopentenyl pyrophosphate.	Hydrogen	57-65	complement C2	Homo sapiens	69-72
28295117-2	2017	The Ecm inhibition and rotational enhancement observed for these reactions at Ecm &lt; 0.5 eV are generally consistent with those reported previously for H2O+ + H2(D2) reactions.	Hydrogen	154-156	multimerin 1	Homo sapiens	4-7
28295117-2	2017	The Ecm inhibition and rotational enhancement observed for these reactions at Ecm &lt; 0.5 eV are generally consistent with those reported previously for H2O+ + H2(D2) reactions.	Hydrogen	154-156	multimerin 1	Homo sapiens	78-81
28154009-6	2017	Here, hydrogen/deuterium exchange mass spectrometry indicated that caspase-6 is inherently and dramatically more conformationally dynamic than closely related caspase-7.	Hydrogen	6-14	caspase 6	Homo sapiens	67-76
28154009-7	2017	In contrast to caspase-7, which rests constitutively in the strand conformation before and after substrate binding, the hydrogen/deuterium exchange data in the L2" and 130"s regions suggested that before substrate binding, caspase-6 exists in a dynamic equilibrium between the helix and strand conformations.	Hydrogen	120-128	caspase 6	Homo sapiens	223-232
6406501-5	1983	Removal of the C-2 hydrogen atom of the substrate was shown to be fully rate-determining with L-serine and partially rate-determining with D-allothreonine as substrate at pH 7.8.	Hydrogen	19-27	complement C2	Homo sapiens	15-18
6830822-0	1983	Photo-CIDNP 1H-NMR studies of bovine pancreatic phospholipase A2 and its zymogen.	Hydrogen	12-14	LOC104974671	Bos taurus	48-64
6843552-1	1983	A 1H NMR study of the Fc region of human IgG1 and IgG3 immunoglobulins is presented.	Hydrogen	2-4	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	50-54
6843552-2	1983	1H NMR data were collected for the Fc and pFc" fragments obtained from human monoclonal IgG1 and IgG3 and also from rabbit IgG.	Hydrogen	0-2	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	97-101
6843552-14	1983	This result makes it possible to identify by 1H NMR IgG3 proteins carrying G3m(st) allotypes.	Hydrogen	45-47	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	52-56
6401402-8	1983	The close correlation between Ea values for bulk water viscosity and osmotic water flow across the bladder wall suggests that an equivalent number of hydrogen bonds must be broken to achieve an increase in water flow through ADH-induced channels and an increase in fluidity of water in bulk solution.	Hydrogen	150-158	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	225-228
6891601-1	1982	The cancer chemotherapeutic drug cis-diamminedichloroplatinum (II) (cis-DDP) was reacted with deoxyribonucleosides, and the products were separated by high-pressure liquid chromatography and characterized by 1H nuclear magnetic resonance.	Hydrogen	208-210	translocase of inner mitochondrial membrane 8A	Homo sapiens	72-75
6284503-0	1982	1H NMR studies of eukaryotic cytochrome c.	Hydrogen	0-2	cytochrome c, somatic	Equus caballus	29-41
6284504-0	1982	1H NMR studies of the electron exchange between cytochrome c and iron hexacyanides.	Hydrogen	0-2	cytochrome c, somatic	Equus caballus	48-60
7141529-3	1982	All compounds exhibited the (M-OH)+ ion, for which the hydrogen abstraction is non-specific, involving the C-2 and C-3 positions in the methylbutyl homolog.	Hydrogen	55-63	complement C2	Homo sapiens	107-110
7326032-9	1981	The data obtained indicate that the epimerization of D-glucuronosyl to L-iduronosyl residues during biosynthesis of dermatan sulphate involves an abstraction of the C-5 hydrogen of the uronosyl residue.	Hydrogen	169-177	complement C5	Homo sapiens	165-168
6261826-0	1981	1H-NMR studies of structural homologies between the heme environments in horse cytochrome c and in cytochrome c-552 from Euglena gracilis.	Hydrogen	0-2	cytochrome c, somatic	Equus caballus	79-91
6261826-0	1981	1H-NMR studies of structural homologies between the heme environments in horse cytochrome c and in cytochrome c-552 from Euglena gracilis.	Hydrogen	0-2	cytochrome c, somatic	Equus caballus	99-111
7013787-0	1981	Environment of the tryptophan residues in a myosin head: a hydrogen-deuterium exchange study.	Hydrogen	59-67	myosin heavy chain 14	Homo sapiens	44-50
7213612-2	1981	The high-resolution 1H NMR detected internal motions in myosin and myosin subfragment 1 (S1) [Highsmith, S., Akasaka, K., Konrad, M., Goody, R., Holmes, K., Wade-Jardetzky, N., &amp; Jardetzky, O.	Hydrogen	20-22	myosin heavy chain 14	Homo sapiens	56-62
7213612-2	1981	The high-resolution 1H NMR detected internal motions in myosin and myosin subfragment 1 (S1) [Highsmith, S., Akasaka, K., Konrad, M., Goody, R., Holmes, K., Wade-Jardetzky, N., &amp; Jardetzky, O.	Hydrogen	20-22	myosin heavy chain 14	Homo sapiens	67-73
6997310-1	1980	The steric course of the methyl group transfer catalyzed by catechol O-methyltransferase was studied using S-adenosylmethionine (AdoMet) carrying a methyl group made chiral by labeling with 1H, 2H, and 3H in an asymmetrical arrangement.	Hydrogen	190-192	catechol-O-methyltransferase	Rattus norvegicus	60-88
7419519-5	1980	Purified EF-1H was analyzed by polyacrylamide gel electrophoresis under non-denaturing conditions and glycerol gradient centrifugation, revealing that it is apparently homogeneous and has both EF-1 alpha and EF-1 beta gamma activities.	Hydrogen	12-14	EF1ALPHA	Sus scrofa	193-203
21938455-7	2012	In place of the typical "D/ERY"-motif-mediated "ionic lock", a hydrogen bond mediated by the "DAY" motif was observed that could be used to distinguish the agonist and antagonist bound forms of OA1.	Hydrogen	63-71	G protein-coupled receptor 143	Homo sapiens	194-197
7419519-6	1980	The subunit structure of EF-1H was investigated by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate as well as two-dimensional gel electrophoresis, which indicated that EF-1H consists of three different subunits, i.e., EF-1 alpha, EF-1 beta, and EF-1 gamma, in an equimolar ratio.	Hydrogen	28-30	EF1ALPHA	Sus scrofa	247-257
7419519-6	1980	The subunit structure of EF-1H was investigated by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate as well as two-dimensional gel electrophoresis, which indicated that EF-1H consists of three different subunits, i.e., EF-1 alpha, EF-1 beta, and EF-1 gamma, in an equimolar ratio.	Hydrogen	200-202	EF1ALPHA	Sus scrofa	247-257
21779925-0	2012	1H, 13C, 15N and 31P chemical shift assignments of a human Xist RNA A-repeat tetraloop hairpin essential for X-chromosome inactivation.	Hydrogen	0-2	X inactive specific transcript	Homo sapiens	59-63
7419519-9	1980	Thus, we concluded that EF-1H is a monomer of a 1:1:1 complex of EF-1 alpha, EF-1 beta, and EF-1 gamma, or EF-1 alpha beta gamma and its molecular weight is 136,000.	Hydrogen	27-29	EF1ALPHA	Sus scrofa	65-75
7419519-9	1980	Thus, we concluded that EF-1H is a monomer of a 1:1:1 complex of EF-1 alpha, EF-1 beta, and EF-1 gamma, or EF-1 alpha beta gamma and its molecular weight is 136,000.	Hydrogen	27-29	EF1ALPHA	Sus scrofa	107-117
7419519-10	1980	This conclusion was further confirmed by measuring the amounts of EF-1 alpha and EF-1 beta gamma in EF-1H by enzymatic assays.	Hydrogen	103-105	EF1ALPHA	Sus scrofa	66-76
22201036-0	2012	1H, 13C and 15N resonance assignments of the kinetochore localisation domain of BUBR1, a central component of the spindle assembly checkpoint.	Hydrogen	0-2	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	80-85
28298220-5	2017	According to three-dimensional structures of Erv1 and protein stability assays, S32 and N34 residues interact with nearby residues through hydrogen bonding and greatly contribute to protein stability.	Hydrogen	139-147	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	45-49
7419519-11	1980	The amino acid composition of EF-1H was determined, and the results revealed that there was a close resemblance between the values of EF-1H and those of EF-1 alpha beta gamma, which were calculated from the reported values for EF-1 alpha, EF-1 beta, and EF-1 gamma.	Hydrogen	33-35	EF1ALPHA	Sus scrofa	153-163
22527961-7	2012	A hydrogen bond to the equivalent residues of JAK3 and most CDKs cannot be formed resulting in good selectivity for JAK2 over JAK3 and CDKs.	Hydrogen	2-10	Janus kinase 3	Homo sapiens	46-50
22527961-7	2012	A hydrogen bond to the equivalent residues of JAK3 and most CDKs cannot be formed resulting in good selectivity for JAK2 over JAK3 and CDKs.	Hydrogen	2-10	Janus kinase 3	Homo sapiens	126-130
7407045-3	1980	The unusual stoichiometry of one progesterone to two uteroglobin dimers is confirmed by 1H NMR.	Hydrogen	88-90	secretoglobin family 1A member 1	Homo sapiens	53-64
22276555-8	2012	MP2 method, even with the largest basis set used, manages to reproduce only less than 50% of the experimentally detected frequency downshift for the hydrogen-bonded dimer.	Hydrogen	149-157	tryptase pseudogene 1	Homo sapiens	0-3
28272319-0	2017	Facilitated Visual Interpretation of Scores in Principal Component Analysis by Bioactivity-Labeling of 1H-NMR Spectra-Metabolomics Investigation and Identification of a New alpha-Glucosidase Inhibitor in Radix Astragali.	Hydrogen	103-105	sucrase-isomaltase	Homo sapiens	173-190
28272319-4	2017	A principal component analysis of the 1H-NMR spectra labeled with their IC50-values, that is, bioactivity-labeled 1H-NMR spectra, showed a clear correlation between spectral profiles and the alpha-glucosidase inhibitory activity.	Hydrogen	38-40	sucrase-isomaltase	Homo sapiens	191-208
28272319-4	2017	A principal component analysis of the 1H-NMR spectra labeled with their IC50-values, that is, bioactivity-labeled 1H-NMR spectra, showed a clear correlation between spectral profiles and the alpha-glucosidase inhibitory activity.	Hydrogen	114-116	sucrase-isomaltase	Homo sapiens	191-208
7190440-0	1980	1H-NMR and photochemically-induced dynamic nuclear polarization studies on bovine pancreatic phospholipase A2.	Hydrogen	0-2	LOC104974671	Bos taurus	93-109
28063937-5	2017	METHODS: We used 1H nuclear magnetic resonance-based metabolomics to investigate the metabolic features of the CSF from 18 TBM and 20 VM patients.	Hydrogen	17-19	colony stimulating factor 2	Homo sapiens	111-114
22055239-2	2012	The suggestion that the interaction between the hydrogen bond donor site H1 with the 3-carbonyl oxygen in 3-carbonylquinolin-4-ones can be replaced by an interaction between H1 and N-2 in the isothiazoloquinolin-4-ones, was confirmed.	Hydrogen	48-56	H1.5 linker histone, cluster member	Homo sapiens	174-184
7397204-3	1980	The labelling pattern of bile acids formed during metabolism of [1,1-2H]-ethanol indicated that the hydrogen at C-5 was labelled in all bile acids.	Hydrogen	100-108	complement C5	Rattus norvegicus	112-115
22100306-5	2012	Like p73, but unlike p53, p63 requires a second helix (H2) to stabilize the architecture of the tetramer.	Hydrogen	55-57	tumor protein p63	Homo sapiens	26-29
27998708-0	2017	Conformations of JNK3alpha splice variants analyzed by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	55-63	mitogen-activated protein kinase 10	Homo sapiens	17-26
7390054-1	1980	The ED50 value for exogenous gastrin stimulation of gastric acid secretion in the cat is about 300 pmol kg-1h-1.	Hydrogen	107-109	gastrin	Homo sapiens	29-36
28062800-0	2017	Novel Allosteric Pathway of Eg5 Regulation Identified through Multivariate Statistical Analysis of Hydrogen-Exchange Mass Spectrometry (HX-MS) Ligand Screening Data.	Hydrogen	99-107	kinesin family member 11	Homo sapiens	28-31
22524024-1	2012	In this study, we investigated the photochemical production of hydrogen from water using bio-inspired heterogeneous microporous porphyrin coordination lattices (PCLs), [Ru2(MTCPP)BF4] (M = H2 (PCL-1), Zn (PCL-2); TCPP = Tetrakis(4-carboxyphenyl)porphyrin), under visible (380 nm &lt;) and UV (320 nm &lt;) light irradiations.	Hydrogen	63-71	metal response element binding transcription factor 2	Homo sapiens	205-210
22524024-2	2012	In the presence of Na2EDTA (as a sacrificial donor) and MV2+ (methyl-vilologen; as a electron relay), PCLs exhibits photocatalytic activity for hydrogen evolution; the maximum amounts of turnover numbers (TONs) of PCL-1 and PCL-2 at 24 h irradiation were 20.8 and 29.9, respectively.	Hydrogen	144-152	metal response element binding transcription factor 2	Homo sapiens	224-229
18699444-1	1979	Simple and versatile quartz tube orifice leaks, suitable for sampling of gas mixtures to mass spectrometers, have been made by heating the tip of a quartz tube in a hydrogen-oxygen flame.	Hydrogen	165-173	TOR signaling pathway regulator	Homo sapiens	139-142
22431983-3	2012	Comparative analysis of the crystal structures of H-2K(b)/gp34 and H-2K(b)/NY-gp34 demonstrated that nitrotyrosination of p3Y in gp34 abrogates a hydrogen bond interaction formed with the H-2K(b) residue E152.	Hydrogen	146-154	TNF superfamily member 4	Homo sapiens	58-62
22431983-3	2012	Comparative analysis of the crystal structures of H-2K(b)/gp34 and H-2K(b)/NY-gp34 demonstrated that nitrotyrosination of p3Y in gp34 abrogates a hydrogen bond interaction formed with the H-2K(b) residue E152.	Hydrogen	146-154	TNF superfamily member 4	Homo sapiens	78-82
22431983-3	2012	Comparative analysis of the crystal structures of H-2K(b)/gp34 and H-2K(b)/NY-gp34 demonstrated that nitrotyrosination of p3Y in gp34 abrogates a hydrogen bond interaction formed with the H-2K(b) residue E152.	Hydrogen	146-154	TNF superfamily member 4	Homo sapiens	78-82
22003888-2	2011	Similar to the homologous histamine H(3) receptor (H(3)R), two acidic residues in the H(4)R binding pocket, D(3.32) and E(5.46), act as essential hydrogen bond acceptors of positively ionizable hydrogen bond donors in H(4)R ligands.	Hydrogen	146-154	histamine receptor H3	Homo sapiens	26-57
22003888-2	2011	Similar to the homologous histamine H(3) receptor (H(3)R), two acidic residues in the H(4)R binding pocket, D(3.32) and E(5.46), act as essential hydrogen bond acceptors of positively ionizable hydrogen bond donors in H(4)R ligands.	Hydrogen	146-154	histamine receptor H4	Homo sapiens	86-91
22003888-2	2011	Similar to the homologous histamine H(3) receptor (H(3)R), two acidic residues in the H(4)R binding pocket, D(3.32) and E(5.46), act as essential hydrogen bond acceptors of positively ionizable hydrogen bond donors in H(4)R ligands.	Hydrogen	146-154	histamine receptor H4	Homo sapiens	218-223
22003888-2	2011	Similar to the homologous histamine H(3) receptor (H(3)R), two acidic residues in the H(4)R binding pocket, D(3.32) and E(5.46), act as essential hydrogen bond acceptors of positively ionizable hydrogen bond donors in H(4)R ligands.	Hydrogen	194-202	histamine receptor H3	Homo sapiens	26-57
22003888-2	2011	Similar to the homologous histamine H(3) receptor (H(3)R), two acidic residues in the H(4)R binding pocket, D(3.32) and E(5.46), act as essential hydrogen bond acceptors of positively ionizable hydrogen bond donors in H(4)R ligands.	Hydrogen	194-202	histamine receptor H4	Homo sapiens	86-91
28082111-7	2017	In addition, molecular docking assay showed that dioscin directly targeted with FXR through competing with Helix12 (H12) by hydrogen bonding, hydrophobic effect and electrostatic interactions.	Hydrogen	124-132	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	80-83
28082425-7	2017	Allosteric propagation proceeds from Nedd8 via Cul5 dynamic hinges and hydrogen bonds between the C-terminal domain of Cul5 (Cul5CTD) and Rbx1 (Cul5CTD residues R538/R569 and Rbx1 residue E67, or Cul5CTD E474/E478/N491 and Rbx1 K105).	Hydrogen	71-79	cullin 5	Homo sapiens	119-123
28082425-7	2017	Allosteric propagation proceeds from Nedd8 via Cul5 dynamic hinges and hydrogen bonds between the C-terminal domain of Cul5 (Cul5CTD) and Rbx1 (Cul5CTD residues R538/R569 and Rbx1 residue E67, or Cul5CTD E474/E478/N491 and Rbx1 K105).	Hydrogen	71-79	cullin 5	Homo sapiens	125-132
28082425-7	2017	Allosteric propagation proceeds from Nedd8 via Cul5 dynamic hinges and hydrogen bonds between the C-terminal domain of Cul5 (Cul5CTD) and Rbx1 (Cul5CTD residues R538/R569 and Rbx1 residue E67, or Cul5CTD E474/E478/N491 and Rbx1 K105).	Hydrogen	71-79	cullin 5	Homo sapiens	144-151
28082425-7	2017	Allosteric propagation proceeds from Nedd8 via Cul5 dynamic hinges and hydrogen bonds between the C-terminal domain of Cul5 (Cul5CTD) and Rbx1 (Cul5CTD residues R538/R569 and Rbx1 residue E67, or Cul5CTD E474/E478/N491 and Rbx1 K105).	Hydrogen	71-79	cullin 5	Homo sapiens	144-151
574451-0	1979	Investigation by 360-MHz 1H-nuclear-magnetic-resonance spectroscopy and methylation analysis of the single glycan chain of chicken ovotransferrin.	Hydrogen	25-27	transferrin (ovotransferrin)	Gallus gallus	131-145
27878872-1	2017	Carbon electrocatalysts consisting of metal complexes such as MNx or MSx are promising alternatives to high-cost Pt catalysts for the hydrogen evolution reaction (HER).	Hydrogen	134-142	keratin 86	Homo sapiens	62-65
22153504-4	2011	High-affinity binding by Raver1 PRI3 involves shape-matched apolar contacts complemented by specific hydrogen bonds, a new variant of an established mode of peptide-RRM interaction.	Hydrogen	101-109	ribonucleoprotein, PTB binding 1	Homo sapiens	25-31
22220112-2	2011	In the crystal, N-H O hydrogen bonds link the mol-ecules into C(4) chains, which propagate along the b-axis direction.	Hydrogen	22-30	complement C4A (Rodgers blood group)	Homo sapiens	62-66
519028-3	1979	When 3H-thymidine was injected to the mice at 2 a. m., tG2min was 1h; tG2+1/2 M was 2h; tS was 7.1; tG1+1/2 M was 2h; tS was 7.1; tG1+1/2 M was 15.9h.	Hydrogen	66-68	transglutaminase 2, C polypeptide	Mus musculus	55-58
21972974-7	2011	These data demonstrate hydrogen-bonding interactions between the carbonyl group of the C(alpha) substituent of E2 and the side chain of Asn180 present in the active site of MMP1.	Hydrogen	23-31	matrix metallopeptidase 1	Homo sapiens	173-177
28087437-9	2017	Furthermore, the protective effects of hydrogen-rich saline were accompanied by the increased activity of glucose-regulated protein 78 (GRP78), the decreased activity of cysteinyl aspartate specific proteinase-12 (caspase-12) and C/EBP homologous protein (CHOP).	Hydrogen	39-47	DNA-damage inducible transcript 3	Rattus norvegicus	230-254
28087437-9	2017	Furthermore, the protective effects of hydrogen-rich saline were accompanied by the increased activity of glucose-regulated protein 78 (GRP78), the decreased activity of cysteinyl aspartate specific proteinase-12 (caspase-12) and C/EBP homologous protein (CHOP).	Hydrogen	39-47	DNA-damage inducible transcript 3	Rattus norvegicus	256-260
437116-0	1979	Loss of C-5 hydrogen during oxidation of UDP-D-glucose by UDP-D-glucose dehydrogenase.	Hydrogen	12-20	complement C5	Homo sapiens	8-11
27894824-4	2017	The intrinsic fluorescence of alpha-glucosidase was quenched by the interactions with phloretin through a static quenching mechanism and spontaneously formed phloretin-alpha-glucosidase complex by the driving forces of van der Waals force and hydrogen bond.	Hydrogen	243-251	sucrase-isomaltase	Homo sapiens	30-47
27894824-4	2017	The intrinsic fluorescence of alpha-glucosidase was quenched by the interactions with phloretin through a static quenching mechanism and spontaneously formed phloretin-alpha-glucosidase complex by the driving forces of van der Waals force and hydrogen bond.	Hydrogen	243-251	sucrase-isomaltase	Homo sapiens	168-185
22313292-6	2011	Further, the study also reveals that the polarizability and hydrogen bond acceptor/donor groups are important for the alpha-glucosidase inhibitory activity and these results are in agreement with the earlier studies obtained in our laboratory on alpha-glucosidase inhibitors which have shows that the polar surface area of the molecule is important for the interaction.	Hydrogen	60-68	sucrase-isomaltase	Homo sapiens	118-135
22313292-6	2011	Further, the study also reveals that the polarizability and hydrogen bond acceptor/donor groups are important for the alpha-glucosidase inhibitory activity and these results are in agreement with the earlier studies obtained in our laboratory on alpha-glucosidase inhibitors which have shows that the polar surface area of the molecule is important for the interaction.	Hydrogen	60-68	sucrase-isomaltase	Homo sapiens	246-263
21913687-0	2011	Reaction mechanism for the thermal decomposition of BCl3/CH4/H2 gas mixtures.	Hydrogen	61-63	BCL3 transcription coactivator	Homo sapiens	52-56
705305-5	1978	Individual H2 excretion before lactulose ingestion was highly variable: 0.096 +/- 0.075 mlH2 (mean +/- 1 SD); the individual base line rate over a fasting period showed marked fluctuations.	Hydrogen	11-13	PMS1 homolog 1, mismatch repair system component	Homo sapiens	88-92
21994155-1	2011	A TiO2/FTO (FTO=fluorine-doped tin oxide) electrode was prepared by dip-coating FTO in a suspension of TiO2 prepared from a sol-gel method and was used as a photoanode to split an aqueous solution of formic acid to produce hydrogen.	Hydrogen	223-231	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	7-10
21994155-1	2011	A TiO2/FTO (FTO=fluorine-doped tin oxide) electrode was prepared by dip-coating FTO in a suspension of TiO2 prepared from a sol-gel method and was used as a photoanode to split an aqueous solution of formic acid to produce hydrogen.	Hydrogen	223-231	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	12-15
21994155-1	2011	A TiO2/FTO (FTO=fluorine-doped tin oxide) electrode was prepared by dip-coating FTO in a suspension of TiO2 prepared from a sol-gel method and was used as a photoanode to split an aqueous solution of formic acid to produce hydrogen.	Hydrogen	223-231	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	12-15
28356943-5	2017	Silencing of LASS2 in RT4 cells was able to increase V-ATPase activity, the extracellular hydrogen ion concentration and, in turn, the activation of secreted matrix metalloproteinase (MMP)-2 and MMP-9, which occurred simultaneously with enhanced cell proliferation, cell survival and cell invasion in vitro, as well as acceleration of BC growth in vivo.	Hydrogen	90-98	ceramide synthase 2	Homo sapiens	13-18
27727489-6	2017	In addition, the intermolecular hydrogen bond network that kept the AM stable in the binding site of KLHL3 was disrupted, and the forces for the hydrophobic interactions between the AM of WNK4 and KLHL3 were also reduced.	Hydrogen	32-40	WNK lysine deficient protein kinase 4	Homo sapiens	188-192
27727489-8	2017	In conclusion, phosphorylation of KLHL3 at S433 disrupts the hydrogen bonds, hydrophobic and electrostatic interactions between the Kelch domain of KLHL3 and the AM of WNK4.	Hydrogen	61-69	WNK lysine deficient protein kinase 4	Homo sapiens	168-172
27936804-1	2017	With first-principles calculations, we find a new strategy for developing high-performance catalysts for hydrogen evolution reaction (HER) via controlling the morphology and size of nanopolygons of monolayer transition-metal dichalcogenides (npm-MS2, with M = Mo, W, or V).	Hydrogen	105-113	MS2	Homo sapiens	246-249
647852-0	1978	Stereospecific hydrogen transfer from C-4 to C-6 during enzymatic transformation of cholesterol into cholestenone.	Hydrogen	15-23	complement C4A (Rodgers blood group)	Homo sapiens	38-48
21961588-3	2011	Here, potential of mean force for complete conduction events of Na(+) and K(+) ions through NaK show that: i), large energy barriers prevent the passage of ions through the WT NaK structure, ii), the barriers are correlated to the presence of a hydrogen bond between Asp-66 and Asn-68, and iii), the structure of NaK mutated to mimic cyclic nucleotide-gated channels conducts Na(+) and K(+).	Hydrogen	245-253	TANK binding kinase 1	Homo sapiens	92-95
21961588-3	2011	Here, potential of mean force for complete conduction events of Na(+) and K(+) ions through NaK show that: i), large energy barriers prevent the passage of ions through the WT NaK structure, ii), the barriers are correlated to the presence of a hydrogen bond between Asp-66 and Asn-68, and iii), the structure of NaK mutated to mimic cyclic nucleotide-gated channels conducts Na(+) and K(+).	Hydrogen	245-253	TANK binding kinase 1	Homo sapiens	176-179
21961588-3	2011	Here, potential of mean force for complete conduction events of Na(+) and K(+) ions through NaK show that: i), large energy barriers prevent the passage of ions through the WT NaK structure, ii), the barriers are correlated to the presence of a hydrogen bond between Asp-66 and Asn-68, and iii), the structure of NaK mutated to mimic cyclic nucleotide-gated channels conducts Na(+) and K(+).	Hydrogen	245-253	TANK binding kinase 1	Homo sapiens	176-179
21961602-5	2011	Hydrogen exchange indicates that neuroserpin has greater flexibility in the breach region and in beta-strand 1C compared with alpha(1)-antitrypsin.	Hydrogen	0-8	serpin family I member 1	Homo sapiens	33-44
27700100-6	2017	Hydrogen-deuterium exchange and a cell-free MHC class II antigen processing system revealed that proteolysis of PAD4 by GrB induced discrete structural changes in PAD4 that promoted enhanced presentation of several immunogenic peptides capable of stimulating PAD4-specific CD4+ T cells from patients with RA.	Hydrogen	0-8	peptidyl arginine deiminase 4	Homo sapiens	112-116
303687-0	1977	B-lymphocyte Fc receptor-associated non-H-2 antigens are determined by a single polymorphic locus which is linked to the Mls locus.	Hydrogen	40-43	Fc receptor	Mus musculus	13-24
27700100-6	2017	Hydrogen-deuterium exchange and a cell-free MHC class II antigen processing system revealed that proteolysis of PAD4 by GrB induced discrete structural changes in PAD4 that promoted enhanced presentation of several immunogenic peptides capable of stimulating PAD4-specific CD4+ T cells from patients with RA.	Hydrogen	0-8	granzyme B	Homo sapiens	120-123
27700100-6	2017	Hydrogen-deuterium exchange and a cell-free MHC class II antigen processing system revealed that proteolysis of PAD4 by GrB induced discrete structural changes in PAD4 that promoted enhanced presentation of several immunogenic peptides capable of stimulating PAD4-specific CD4+ T cells from patients with RA.	Hydrogen	0-8	peptidyl arginine deiminase 4	Homo sapiens	163-167
21838258-6	2011	Based on the MP2/CBS results, the most stable C(6)H(6)(MeOH)(3) cluster is characterized by a hydrogen bonded MeOH trimer chain interacting with benzene via pi   H-O and O   H-C(benzene) hydrogen bonds.	Hydrogen	94-102	tryptase pseudogene 1	Homo sapiens	13-16
21838258-6	2011	Based on the MP2/CBS results, the most stable C(6)H(6)(MeOH)(3) cluster is characterized by a hydrogen bonded MeOH trimer chain interacting with benzene via pi   H-O and O   H-C(benzene) hydrogen bonds.	Hydrogen	187-195	tryptase pseudogene 1	Homo sapiens	13-16
303687-3	1977	Backcross experiments revealed that the B-cell Fc receptor-associated non-H-2 antigens were determined by the gene(s) of a single background locus in each of the three strains tested (A/J, B10, and CBA/J).	Hydrogen	74-77	Fc receptor	Mus musculus	47-58
21421306-2	2011	The greatest specific hydrogen production rate ( r(H2) was observed in Stage 3 as 3.4 L-H2 L(-1) day(-1) with a volumetric loading rate (VLR) of 100 g-CODL(-1) day(-1); the highest hydrogen yield was observed in Stage 2 as 96 mL-H2 g(-1) of influent VSS with a VLR of 46 g-COD L(-1) day(-1).	Hydrogen	22-30	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	86-90
27774878-5	2017	Docking results identified pi-pi, hydrogen bonds as the most important noncovalent interactions between HDAC8 (PDB: 3F07) and the ligands tested, whereas Belm4 was the best QSAR descriptor and classified as a 2D-BCUT descriptor.	Hydrogen	34-42	histone deacetylase 8	Homo sapiens	104-109
21421306-2	2011	The greatest specific hydrogen production rate ( r(H2) was observed in Stage 3 as 3.4 L-H2 L(-1) day(-1) with a volumetric loading rate (VLR) of 100 g-CODL(-1) day(-1); the highest hydrogen yield was observed in Stage 2 as 96 mL-H2 g(-1) of influent VSS with a VLR of 46 g-COD L(-1) day(-1).	Hydrogen	51-53	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	86-90
21189-0	1977	Hydrogen exchange study of membrane-bound rhodopsin.	Hydrogen	0-8	rhodopsin	Bos taurus	42-51
26728967-2	2017	Cyclic cHAVc3 peptide (cyclo(1,6)Ac-CSHAVC-NH2) binds to the EC1 domain as shown by chemical shift perturbations in the 2D 1H,-15N-HSQC NMR spectrum.	Hydrogen	123-125	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	61-64
410500-2	1977	analysis, it was shown that the hydrogen atom introduced on C-2 is trans-related to the aglycon moiety.	Hydrogen	32-40	complement C2	Homo sapiens	60-63
28737429-1	2017	In this study, we have employed 1H NMR metabolomics to assess the metabolic responses of PC3 prostate tumour cells to hypoxia and to pharmacological HIF-1alpha inhibition by DES or its polyacetal conjugate tert-DES.	Hydrogen	32-34	chromobox 8	Homo sapiens	89-92
21663964-4	2011	However, BI-1 is also a negative regulator of the endoplasmic reticulum stress sensor IRE1 alpha, it interacts with G-actin and increases actin polymerization, enhances cancer metastasis by altering glucose metabolism and activating the sodium-hydrogen exchanger, and reduces the production of reactive oxygen species through direct interaction with NADPH-P450 reductase.	Hydrogen	244-252	transmembrane BAX inhibitor motif containing 6	Homo sapiens	9-13
22040412-8	2011	IDH1 changes of binding free energy (DeltaE) suggested that the A132Arg residue from chain A contributes three hydrogen bonds to the ICT alpha-carboxyl and beta-carboxyl groups, while the other nine residues involved in ICT binding form only one or two hydrogen bonds.	Hydrogen	111-119	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
22040412-8	2011	IDH1 changes of binding free energy (DeltaE) suggested that the A132Arg residue from chain A contributes three hydrogen bonds to the ICT alpha-carboxyl and beta-carboxyl groups, while the other nine residues involved in ICT binding form only one or two hydrogen bonds.	Hydrogen	253-261	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
851476-6	1977	H-1 RF DNA has been found to dimerize by hydrogen-bounded linkage at the molecular left end, and in some molecules the viral strand is covalently linked to the complementary strand.	Hydrogen	41-49	H1.5 linker histone, cluster member	Homo sapiens	0-3
21539938-5	2011	These results indicate that both aromatic interaction and hydrogen bonding are involved in ligand binding for the residue W5.43(194), and the mutations of this tryptophan site may affect the conformation of the ligand binding pocket and therefore control the active conformation of the wild type CB2 receptor.	Hydrogen	58-66	cannabinoid receptor 2	Homo sapiens	296-299
28216884-11	2017	Abbreviation used: IDO: inhibit indoleamine 2, 3-dioxygenase, TMS: tetramethylsilane, HMQC: heteronuclear multiple quantum correlation, HMBC: heteronuclear multiple bond correlation, COSY: 1H-1H correlation spectroscopy, ESI-MS: Electrospray ionization mass spectrometry, DMSO: dimethyl sulfoxide.	Hydrogen	189-191	indoleamine 2,3-dioxygenase 1	Homo sapiens	19-22
28216884-11	2017	Abbreviation used: IDO: inhibit indoleamine 2, 3-dioxygenase, TMS: tetramethylsilane, HMQC: heteronuclear multiple quantum correlation, HMBC: heteronuclear multiple bond correlation, COSY: 1H-1H correlation spectroscopy, ESI-MS: Electrospray ionization mass spectrometry, DMSO: dimethyl sulfoxide.	Hydrogen	192-194	indoleamine 2,3-dioxygenase 1	Homo sapiens	19-22
12155-0	1976	Hydrogen-deuterium exchange in the histidine residues of bovine alpha-lactalbumin.	Hydrogen	0-8	lactalbumin alpha	Bos taurus	64-81
21633735-0	2011	Cooperative hydrogen bonding in trimers involving HCN and HBO.	Hydrogen	12-20	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	50-53
21633735-1	2011	A computational study of the cooperative effect of hydrogen bonding in linear trimers comprised of HCN and HBO molecules was undertaken at the MP2/6-311++G(2d,2p) level of theory.	Hydrogen	51-59	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	99-102
21633735-1	2011	A computational study of the cooperative effect of hydrogen bonding in linear trimers comprised of HCN and HBO molecules was undertaken at the MP2/6-311++G(2d,2p) level of theory.	Hydrogen	51-59	tryptase pseudogene 1	Homo sapiens	143-146
21698334-4	2011	This site serves as an electron-donor site to electrophiles, resulting in hydrogen-bonded complexes of B(2)H(4) with proton donors HF, HNC, HCl, HCN, and HCCH, and a van der Waals complex with H(2).	Hydrogen	74-82	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	145-148
963237-0	1976	Hydrogen-deuterium exchange of the tryptophan residues in bovine alpha-lactalbumin.	Hydrogen	0-8	lactalbumin alpha	Bos taurus	65-82
21711014-8	2011	By a combination of structural and chemical modification studies, we show that metal binding is only slow when the rest of the inhibitor makes optimal hydrogen bonds within the subsites of PDF.	Hydrogen	151-159	peptide deformylase, mitochondrial	Homo sapiens	189-192
28036396-7	2016	A Grid-Independent Molecular Descriptor (GRIND) analysis indicated that two hydrogen bond acceptors, two hydrogen bond donors and one hydrophobic feature at a certain distance from each other were important for the selective inhibition of Akt2.	Hydrogen	76-84	AKT serine/threonine kinase 2	Homo sapiens	239-243
28036396-7	2016	A Grid-Independent Molecular Descriptor (GRIND) analysis indicated that two hydrogen bond acceptors, two hydrogen bond donors and one hydrophobic feature at a certain distance from each other were important for the selective inhibition of Akt2.	Hydrogen	105-113	AKT serine/threonine kinase 2	Homo sapiens	239-243
1254586-3	1976	When the reaction with the liver microsomal system was carried out in 2H2O with the protium species of serine, the sphinganine contained a deuterium atom on C-2.	Hydrogen	84-91	complement C2	Rattus norvegicus	157-160
28030592-6	2016	We also used bioinformatics simulation analysis to predict impact of the mutation on SRY function, and find the R75 in wild type SRY can form a hydrogen bond with serine at 91 (S91) that make the SRY protein well fit into the minor groove of target DNA, while the M75 in the mutated SRY can not.	Hydrogen	144-152	sex determining region Y	Homo sapiens	129-132
28030592-6	2016	We also used bioinformatics simulation analysis to predict impact of the mutation on SRY function, and find the R75 in wild type SRY can form a hydrogen bond with serine at 91 (S91) that make the SRY protein well fit into the minor groove of target DNA, while the M75 in the mutated SRY can not.	Hydrogen	144-152	sex determining region Y	Homo sapiens	129-132
28030592-6	2016	We also used bioinformatics simulation analysis to predict impact of the mutation on SRY function, and find the R75 in wild type SRY can form a hydrogen bond with serine at 91 (S91) that make the SRY protein well fit into the minor groove of target DNA, while the M75 in the mutated SRY can not.	Hydrogen	144-152	sex determining region Y	Homo sapiens	129-132
1214811-3	1975	A statistical analysis of side group-backbone hydrogen bonds is carried out for three proteins: alpha-chy-motrypsin, lysozyme and myoglobin.	Hydrogen	46-54	myoglobin	Homo sapiens	130-139
27959512-2	2016	Here, we employ time-resolved electrospray ionization hydrogen-deuterium exchange (TRESI-HDX) to characterize the changes in dynamics that accompany oligonucleotide binding in the atypical RNA recognition motif (RRM2) in the C-terminal domain (CTD) of human La protein.	Hydrogen	54-62	ribonucleotide reductase regulatory subunit M2	Homo sapiens	212-216
28193043-0	2016	Removal of N-Linked Glycosylations at Acidic pH by PNGase A Facilitates Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of N-Linked Glycoproteins.	Hydrogen	72-80	N-glycanase 1	Homo sapiens	51-57
1156576-2	1975	The pro-R hydrogen at C-2 of propionyl-coenzyme A is replaced by CO2 in formation of the S isomer of methylmalonyl-CoA, defining the process as retention of configuration.	Hydrogen	10-18	complement C2	Homo sapiens	22-25
27634931-7	2016	Five potential triple helix forming domains were predicted within the HOTAIR sequence based on reverse Hoogsteen hydrogen bonds.	Hydrogen	113-121	HOX transcript antisense RNA	Homo sapiens	70-76
27973456-8	2016	This crystal structure allowed definition of a short portion of the linker interacting with the Gal-8 N-terminal tail via ionic interactions and hydrogen bonds.	Hydrogen	145-153	galectin 8	Homo sapiens	96-101
1156576-3	1975	This C-2 hydrogen is abstracted at a rate identical with product formation.	Hydrogen	9-17	complement C2	Homo sapiens	5-8
27374556-8	2016	The performance of the immobilized trypsin was demonstrated by carrying out the hydrolysis of bovine serum albumin (BSA) within 1h, and the assay was performed by using liquid chromatography-mass spectrometry (LC-MS/MS) technique.	Hydrogen	128-130	albumin	Bos taurus	101-114
4149127-0	1973	Hydrogen transfer from NADPH to steroid by testicular 20 alpha-hydroxysteroid dehydrogenase: stereospecficity and isotope effect.	Hydrogen	0-8	hydroxysteroid 17-beta dehydrogenase 2	Homo sapiens	54-91
4655423-2	1972	The four diols resulting from replacement of the hydroxy groups at C-1 or C-2 of sn-glycerol by fluorine or hydrogen are weak substrates.	Hydrogen	108-116	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	67-70
27596008-9	2016	Hydrogen gas inhalation markedly improved lung endothelial permeability and decreased both MDA content and MPO activity in lung tissue; these changes were associated with decreases in TNF-alpha, IL-1beta, and IL-6 in BALF.	Hydrogen	0-8	tumor necrosis factor	Oryctolagus cuniculus	184-193
5096069-0	1971	[Proof and characterisation of the microsomal enzyme of human placenta, which acts as a catalyser for the transfer of hydrogen from C-17 of estradiol to the C-17 oxo group of androstenedione].	Hydrogen	118-126	cytokine like 1	Homo sapiens	132-136
27775714-4	2016	Crystal structures of the DPF domain of MOZ in complex with H3K14cr, H3K14bu, and H3K14pr peptides reveal that these non-acetyl acylations are anchored in a hydrophobic "dead-end" pocket with selectivity for crotonylation arising from intimate encapsulation and an amide-sensing hydrogen bonding network.	Hydrogen	279-287	lysine acetyltransferase 6A	Homo sapiens	40-43
5096069-0	1971	[Proof and characterisation of the microsomal enzyme of human placenta, which acts as a catalyser for the transfer of hydrogen from C-17 of estradiol to the C-17 oxo group of androstenedione].	Hydrogen	118-126	cytokine like 1	Homo sapiens	157-161
5289373-3	1971	Nuclear magnetic resonance studies of 1 and 3 show that in 1 the hydrogen atoms at C-2 and C-2", as well as those at C-7 and C-7", are trans relative to one another.	Hydrogen	65-73	complement C2	Homo sapiens	83-86
28039406-9	2016	Across groups, circulating G-CSF was elevated from PRE at IP (P &lt; 0.001), 1H (P = 0.011), and 5H (P = 0.025), while GM-CSF was elevated at IP (P &lt; 0.001) and 1H (P = 0.007).	Hydrogen	77-79	colony stimulating factor 3	Homo sapiens	27-32
28039406-9	2016	Across groups, circulating G-CSF was elevated from PRE at IP (P &lt; 0.001), 1H (P = 0.011), and 5H (P = 0.025), while GM-CSF was elevated at IP (P &lt; 0.001) and 1H (P = 0.007).	Hydrogen	164-166	colony stimulating factor 3	Homo sapiens	27-32
5475946-2	1970	Hydrogen transfer in the glucose- and mannosephosphate isomerase reaction].	Hydrogen	0-8	mannose phosphate isomerase	Homo sapiens	25-64
27768279-0	2016	Efficient Photoelectrochemical Hydrogen Evolution on Silicon Photocathodes Interfaced with Nanostructured NiP2 Cocatalyst Films.	Hydrogen	31-39	BCL2 interacting protein 2	Homo sapiens	106-110
27768279-6	2016	As a result, our pn+-Si/Ti/NiP2 photocathodes demonstrate a great PEC onset potential of 0.41 V versus reversible hydrogen electrode (RHE), a decent photocurrent density of ~12 mA/cm2 at the thermodynamic potential of hydrogen evolution, and an impressive operation durability for at least 6 h in 0.5 M H2SO4.	Hydrogen	114-122	BCL2 interacting protein 2	Homo sapiens	27-31
27768279-6	2016	As a result, our pn+-Si/Ti/NiP2 photocathodes demonstrate a great PEC onset potential of 0.41 V versus reversible hydrogen electrode (RHE), a decent photocurrent density of ~12 mA/cm2 at the thermodynamic potential of hydrogen evolution, and an impressive operation durability for at least 6 h in 0.5 M H2SO4.	Hydrogen	218-226	BCL2 interacting protein 2	Homo sapiens	27-31
5685263-1	1968	When a 3-keto bile acid methyl ester was chromatographed on basic alumina inactivated with tritiated water, the enolic hydrogen atoms at C-2 and C-4 exchanged with tritium atoms.	Hydrogen	119-127	complement C2	Homo sapiens	137-140
27791208-1	2016	In this present study, a series of cobalt porphyrin-based conjugated mesoporous polymers (CoP-nph-CMP, n = 2, 3, 4) were fabricated as catalyst precursors to generate bifunctional catalysts via pyrolysis (CoP-nph-CMP-800, n = 2, 3, 4) for both the oxygen evolution reaction (OER) and the hydrogen evolution reaction (HER).	Hydrogen	288-296	caspase recruitment domain family member 16	Homo sapiens	90-93
5669849-5	1968	d-Galactose</compound-id> and 6-deoxy-6-fluoro-d-galactose were accumulated far more rapidly than 6-deoxy- and 6-chloro-6-deoxy-d-galactose, and this is interpreted as due to hydrogen-bonding at C-6 during the transport process.	Hydrogen	175-183	complement C6	Rattus norvegicus	195-198
27825296-4	2016	RESULTS: Using kinetic binding assays and molecular dynamics simulations of ancestral proteins, we demonstrate how a small number of adaptive protein-coding changes repeatedly shifted the RNA preference of RLRs throughout animal evolution by reorganizing the shape and electrostatic distribution across the RNA binding pocket, altering the hydrogen bond network between the RLR and its RNA target.	Hydrogen	340-348	DExH-box helicase 58	Homo sapiens	206-209
27827376-4	2016	The photocatalytic hydrogen production assessments reveal an initial reaction rate of 380 mumol h-1 and a turnover number of 635 after 48 h. The efficient hydrogen production may derive from the directional electron transfers through multiple channels owing to proper organization of the photo- and catalytic multi-units within the octahedral cage, which may open a new door to design photochemical molecular devices with well-organized metallosupramolecules for homogenous photocatalytic applications.	Hydrogen	19-27	H1.5 linker histone, cluster member	Homo sapiens	96-99
27827376-4	2016	The photocatalytic hydrogen production assessments reveal an initial reaction rate of 380 mumol h-1 and a turnover number of 635 after 48 h. The efficient hydrogen production may derive from the directional electron transfers through multiple channels owing to proper organization of the photo- and catalytic multi-units within the octahedral cage, which may open a new door to design photochemical molecular devices with well-organized metallosupramolecules for homogenous photocatalytic applications.	Hydrogen	155-163	H1.5 linker histone, cluster member	Homo sapiens	96-99
14066941-0	1963	A MOLECULAR THEORY OF MUSCLE CONTRACTION: CALCIUM-DEPENDENT CONTRACTIONS WITH HYDROGEN BOND FORMATION PLUS ATP-DEPENDENT EXTENSIONS OF PART OF THE MYOSIN-ACTIN CROSS-BRIDGES.	Hydrogen	78-86	myosin heavy chain 14	Homo sapiens	147-153
27701804-4	2016	A dual function Mcl-1 inhibitor, which locates at the BH3 domain of Mcl-1 and forms hydrogen bond with His224 to drive a helical QRN conformation, so that it not only interferes with the pro-apoptotic partners, but also facilitates Mcl-1 ubiquitination in living cells, is described.	Hydrogen	84-92	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	16-21
27701804-4	2016	A dual function Mcl-1 inhibitor, which locates at the BH3 domain of Mcl-1 and forms hydrogen bond with His224 to drive a helical QRN conformation, so that it not only interferes with the pro-apoptotic partners, but also facilitates Mcl-1 ubiquitination in living cells, is described.	Hydrogen	84-92	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	68-73
27701804-4	2016	A dual function Mcl-1 inhibitor, which locates at the BH3 domain of Mcl-1 and forms hydrogen bond with His224 to drive a helical QRN conformation, so that it not only interferes with the pro-apoptotic partners, but also facilitates Mcl-1 ubiquitination in living cells, is described.	Hydrogen	84-92	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	68-73
16586660-0	1916	On the Hydrogen Ion Concentration of Sea Water, and the Physiological Effects of the Ions of Sea Water.	Hydrogen	7-15	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	37-40
27704838-9	2016	These amino acids in alpha2, as compared to alpha1, were also observed to decrease the vibrational and dihedral entropy and to increase the hydrogen bond content in alpha2 in the apo state.	Hydrogen	140-148	adrenoceptor alpha 1D	Homo sapiens	44-50
27704838-10	2016	However, freezing of both alpha1 and alpha2 was observed in the ligand-bound state, with an increased number of internal hydrogen bonds and increased entropy.	Hydrogen	121-129	adrenoceptor alpha 1D	Homo sapiens	26-43
27605312-5	2016	The peak volumetric H2 productivity via the in vitro enzymatic pathway comprised of hyperthermophilic glucose 6-phosphate dehydrogenase, 6-phosphogluconolactonase, and 6-phosphogluconate dehydrogenase, NROR, and SH1 was 310 mmol H2 /L h-1 , the highest rate yet reported.	Hydrogen	20-22	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	233-238
34047749-0	2021	Base-promoted, CBr4-mediated tandem bromination/intramolecular Friedel-Crafts alkylation of N-aryl enamines: a facile access to 1H- and 3H-indoles.	Hydrogen	128-130	carbonyl reductase 4	Homo sapiens	15-19
27731623-0	2016	One-Step Electrodeposition of Co/CoP Film on Ni Foam for Efficient Hydrogen Evolution in Alkaline Solution.	Hydrogen	67-75	caspase recruitment domain family member 16	Homo sapiens	33-36
27774529-0	2016	Theoretical study of the H/D isotope effect on phase transition of hydrogen-bonded organic conductor kappa-H3(Cat-EDT-TTF)2. kappa-H3(Cat-EDT-TTF)2 (H-TTF) is a hydrogen-bonded pi-electron system which was found to reveal C2/c symmetry at 50-293 K, while its isotopologue, kappa-D3(Cat-EDT-TTF)2 (D-TTF), showed the phase transition at 185 K from C2/c to P1[combining macron].	Hydrogen	67-75	ras homolog family member H	Homo sapiens	118-121
34037027-0	2021	Interlayer hydrogen bonding directed magnetic properties for a different number of water-intercalated structural heterometallic phosphates based on paddlewheel units Ru2(PO4)46.	Hydrogen	11-19	doublecortin domain containing 2	Homo sapiens	166-176
27774529-0	2016	Theoretical study of the H/D isotope effect on phase transition of hydrogen-bonded organic conductor kappa-H3(Cat-EDT-TTF)2. kappa-H3(Cat-EDT-TTF)2 (H-TTF) is a hydrogen-bonded pi-electron system which was found to reveal C2/c symmetry at 50-293 K, while its isotopologue, kappa-D3(Cat-EDT-TTF)2 (D-TTF), showed the phase transition at 185 K from C2/c to P1[combining macron].	Hydrogen	67-75	ras homolog family member H	Homo sapiens	142-145
27774529-0	2016	Theoretical study of the H/D isotope effect on phase transition of hydrogen-bonded organic conductor kappa-H3(Cat-EDT-TTF)2. kappa-H3(Cat-EDT-TTF)2 (H-TTF) is a hydrogen-bonded pi-electron system which was found to reveal C2/c symmetry at 50-293 K, while its isotopologue, kappa-D3(Cat-EDT-TTF)2 (D-TTF), showed the phase transition at 185 K from C2/c to P1[combining macron].	Hydrogen	67-75	ras homolog family member H	Homo sapiens	142-145
27774529-0	2016	Theoretical study of the H/D isotope effect on phase transition of hydrogen-bonded organic conductor kappa-H3(Cat-EDT-TTF)2. kappa-H3(Cat-EDT-TTF)2 (H-TTF) is a hydrogen-bonded pi-electron system which was found to reveal C2/c symmetry at 50-293 K, while its isotopologue, kappa-D3(Cat-EDT-TTF)2 (D-TTF), showed the phase transition at 185 K from C2/c to P1[combining macron].	Hydrogen	67-75	ras homolog family member H	Homo sapiens	142-145
27774529-0	2016	Theoretical study of the H/D isotope effect on phase transition of hydrogen-bonded organic conductor kappa-H3(Cat-EDT-TTF)2. kappa-H3(Cat-EDT-TTF)2 (H-TTF) is a hydrogen-bonded pi-electron system which was found to reveal C2/c symmetry at 50-293 K, while its isotopologue, kappa-D3(Cat-EDT-TTF)2 (D-TTF), showed the phase transition at 185 K from C2/c to P1[combining macron].	Hydrogen	67-75	ras homolog family member H	Homo sapiens	142-145
21557263-5	2011	A polar hydrogen representation with an implicit solvation term (EEF1) is used to evaluate successively larger fragments of the protein generated in a hierarchical build-up procedure.	Hydrogen	8-16	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	65-69
21723254-6	2011	As ROS is an upstream activator of ASK1, inhibition of ASK1 by hydrogen without suppressing ROS implies that a potential target molecule of hydrogen should be located at the receptor or immediately downstream of it.	Hydrogen	63-71	mitogen-activated protein kinase kinase kinase 5	Mus musculus	35-39
21723254-6	2011	As ROS is an upstream activator of ASK1, inhibition of ASK1 by hydrogen without suppressing ROS implies that a potential target molecule of hydrogen should be located at the receptor or immediately downstream of it.	Hydrogen	63-71	mitogen-activated protein kinase kinase kinase 5	Mus musculus	55-59
21723254-6	2011	As ROS is an upstream activator of ASK1, inhibition of ASK1 by hydrogen without suppressing ROS implies that a potential target molecule of hydrogen should be located at the receptor or immediately downstream of it.	Hydrogen	140-148	mitogen-activated protein kinase kinase kinase 5	Mus musculus	35-39
34014644-0	2021	Functionalization of Zinc Oxide Nanoflowers with Palladium Nanoparticles via Microwave Absorption for Room Temperature-Operating Hydrogen Gas Sensors in the ppb Level.	Hydrogen	129-137	gastrin	Homo sapiens	138-141
21723254-6	2011	As ROS is an upstream activator of ASK1, inhibition of ASK1 by hydrogen without suppressing ROS implies that a potential target molecule of hydrogen should be located at the receptor or immediately downstream of it.	Hydrogen	140-148	mitogen-activated protein kinase kinase kinase 5	Mus musculus	55-59
21553855-3	2011	The yield of DHAP formed by intramolecular transfer of hydrogen decreases from 49% for the muscle enzymes to 40% for wildtype Tbb TIM to 34% for monoTIM.	Hydrogen	55-63	triosephosphate isomerase	Oryctolagus cuniculus	130-133
27476534-0	2016	Distinct roles of a tyrosine-associated hydrogen-bond network in fine-tuning the structure and function of heme proteins: two cases designed for myoglobin.	Hydrogen	40-48	myoglobin	Homo sapiens	145-154
34014644-1	2021	Microwave-assisted functionalization of zinc oxide nanoflowers (ZnO NFs) with palladium nanoparticles (Pd NPs) is demonstrated to realize high-performance chemiresistive-type hydrogen (H2) gas sensors operating at room temperature (RT).	Hydrogen	175-183	gastrin	Homo sapiens	189-192
34015629-7	2021	Moreover, these alterations were related to the abnormal transcriptional levels of peroxisome proliferator-activated receptor alpha (PPAR-alpha) and liver x receptor alpha (LXR-alpha), which were predicted to bind to tebuconazole via hydrogen bonding interactions.	Hydrogen	234-242	peroxisome proliferator activated receptor alpha	Homo sapiens	83-131
27686227-3	2016	Density functional theory (DFT) calculation and experimental results suggest that the coordination and hydrogen bonding interaction between Ir1 and Gln synergistically stabilize the Ir1-Gln complex, modulate charge-transfer characteristics and emission of Ir1, and as a consequence, enable Ir1 as the probe for the fluorescent sensing of Gln.	Hydrogen	103-111	nischarin	Homo sapiens	140-143
27686227-3	2016	Density functional theory (DFT) calculation and experimental results suggest that the coordination and hydrogen bonding interaction between Ir1 and Gln synergistically stabilize the Ir1-Gln complex, modulate charge-transfer characteristics and emission of Ir1, and as a consequence, enable Ir1 as the probe for the fluorescent sensing of Gln.	Hydrogen	103-111	nischarin	Homo sapiens	182-185
27686227-3	2016	Density functional theory (DFT) calculation and experimental results suggest that the coordination and hydrogen bonding interaction between Ir1 and Gln synergistically stabilize the Ir1-Gln complex, modulate charge-transfer characteristics and emission of Ir1, and as a consequence, enable Ir1 as the probe for the fluorescent sensing of Gln.	Hydrogen	103-111	nischarin	Homo sapiens	182-185
27686227-3	2016	Density functional theory (DFT) calculation and experimental results suggest that the coordination and hydrogen bonding interaction between Ir1 and Gln synergistically stabilize the Ir1-Gln complex, modulate charge-transfer characteristics and emission of Ir1, and as a consequence, enable Ir1 as the probe for the fluorescent sensing of Gln.	Hydrogen	103-111	nischarin	Homo sapiens	182-185
27733124-14	2016	CONCLUSIONS: The results suggest that 10 % HS could alleviate cerebral oedema possibly through reducing the ischemia induced BBB permeability as a consequence of inhibiting VEGF-VEGFR2-mediated down-regulation of ZO-1, claudin-5.	Hydrogen	43-45	vascular endothelial growth factor A	Rattus norvegicus	173-177
27733124-14	2016	CONCLUSIONS: The results suggest that 10 % HS could alleviate cerebral oedema possibly through reducing the ischemia induced BBB permeability as a consequence of inhibiting VEGF-VEGFR2-mediated down-regulation of ZO-1, claudin-5.	Hydrogen	43-45	kinase insert domain receptor	Rattus norvegicus	178-184
21574570-6	2011	When the buried water molecules were removed prior to a second 10 ns simulation, beta4 and beta5 formed persistent hydrogen bonds identical to those in rCYB5B, but the Leu21 side chain was forced to adopt a rarely observed conformation.	Hydrogen	115-123	adaptor related protein complex 5 subunit beta 1	Homo sapiens	91-96
21506286-5	2011	Ru/Cs-USY, with a Si/Al ratio of 40, was identified as the most active and selective catalyst for isomerisation of methyl linoleate (cis-9,cis-12 (C18:2)) to CLA at 165  C. Interestingly, no hydrogen pre-treatment of the catalyst or addition of hydrogen donors is required to achieve industrially relevant isomerisation productivities, namely, 0.7 g of CLA per litre of solvent per minute.	Hydrogen	191-199	selectin P ligand	Homo sapiens	158-161
21506286-5	2011	Ru/Cs-USY, with a Si/Al ratio of 40, was identified as the most active and selective catalyst for isomerisation of methyl linoleate (cis-9,cis-12 (C18:2)) to CLA at 165  C. Interestingly, no hydrogen pre-treatment of the catalyst or addition of hydrogen donors is required to achieve industrially relevant isomerisation productivities, namely, 0.7 g of CLA per litre of solvent per minute.	Hydrogen	245-253	selectin P ligand	Homo sapiens	158-161
20659751-3	2011	Hsp27 expression levels increased significantly in the heart after 2h and in the liver after 4h of transportation, accompanying with the hsp27 mRNA increasing significantly in the heart and liver after 1h of transportation.	Hydrogen	202-204	heat shock protein beta-1	Sus scrofa	0-5
34015629-7	2021	Moreover, these alterations were related to the abnormal transcriptional levels of peroxisome proliferator-activated receptor alpha (PPAR-alpha) and liver x receptor alpha (LXR-alpha), which were predicted to bind to tebuconazole via hydrogen bonding interactions.	Hydrogen	234-242	peroxisome proliferator activated receptor alpha	Homo sapiens	133-143
20659751-3	2011	Hsp27 expression levels increased significantly in the heart after 2h and in the liver after 4h of transportation, accompanying with the hsp27 mRNA increasing significantly in the heart and liver after 1h of transportation.	Hydrogen	202-204	heat shock protein beta-1	Sus scrofa	137-142
20659751-5	2011	In conclusion, the cellular damage to the heart and liver is highest after 1h of transportation, Hsp27 and alphaB-crystallin play dissimilar roles and show tissue-specific response in different tissues during transportation.	Hydrogen	75-77	heat shock protein beta-1	Sus scrofa	97-102
27733124-14	2016	CONCLUSIONS: The results suggest that 10 % HS could alleviate cerebral oedema possibly through reducing the ischemia induced BBB permeability as a consequence of inhibiting VEGF-VEGFR2-mediated down-regulation of ZO-1, claudin-5.	Hydrogen	43-45	tight junction protein 1	Rattus norvegicus	213-217
34015331-7	2021	CYP11B2 structure in complex with adrenodoxin identified specific residues at the protein-protein interface interacting via five salt bridges and four hydrogen bonds.	Hydrogen	151-159	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	0-7
27731797-4	2016	Hydrogen-deuterium exchange (HDX) shows that AFF4 helix 2 is stabilized in the TAR complex despite not touching the RNA, explaining how it enhances TAR binding to the SEC 50-fold.	Hydrogen	0-8	AF4/FMR2 family member 4	Homo sapiens	45-49
21491879-0	2011	Large changes of static electric properties induced by hydrogen bonding: an ab initio study of linear HCN oligomers.	Hydrogen	55-63	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	102-105
33549894-6	2021	Notably, the MoS2/CdS hybrid micro-/nanostructures exhibits high photocatalytic hydrogen production activity (9.5 mmol g-1 h-1) and long-lasting cycle stability.	Hydrogen	80-88	CDP-diacylglycerol synthase 1	Homo sapiens	18-21
21427467-2	2011	The approaching hydrogen atoms from both sides of an FLG induce a structural transition from a layered structure into a hydrogen passivated thin diamond film (HP-TDF).	Hydrogen	16-24	filaggrin	Homo sapiens	53-56
21427467-2	2011	The approaching hydrogen atoms from both sides of an FLG induce a structural transition from a layered structure into a hydrogen passivated thin diamond film (HP-TDF).	Hydrogen	120-128	filaggrin	Homo sapiens	53-56
27553983-0	2016	Hexagonal@Cubic CdS Core@Shell Nanorod Photocatalyst for Highly Active Production of H2 with Unprecedented Stability.	Hydrogen	85-87	CDP-diacylglycerol synthase 1	Homo sapiens	16-19
27553983-2	2016	Based on the integration of hexagonal-cubic core-shell architecture with nanorod morphology, the concentric CdS nanorod phase junctions (NRPJs) obtained demonstrate extremely high H2 production rate and unprecedented photocatalytic stability.	Hydrogen	180-182	CDP-diacylglycerol synthase 1	Homo sapiens	108-111
33549897-9	2021	The adsorption of ARG and MB is mainly attributed to electrostatic interaction and hydrogen bonding between ARG or MB and OH in PPm.	Hydrogen	83-91	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	18-21
33549897-9	2021	The adsorption of ARG and MB is mainly attributed to electrostatic interaction and hydrogen bonding between ARG or MB and OH in PPm.	Hydrogen	83-91	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	108-111
21436720-11	2011	Furthermore, administration of hydrogen-rich saline or edaravone dramatically reduced the pulmonary levels of pulmonary inflammation mediators and myeloperoxidase.	Hydrogen	31-39	myeloperoxidase	Rattus norvegicus	147-162
33974881-0	2021	New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via Sodium/Hydrogen Exchanger inhibition.	Hydrogen	86-94	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	15-19
27711283-0	2016	Electrocatalytic hydrogen evolution using the MS2@MoS2/rGO (M = Fe or Ni) hybrid catalyst.	Hydrogen	17-25	MS2	Homo sapiens	46-49
27462076-8	2016	We confirmed this by introducing a hydrogen bond-null propofol analogue as a protecting ligand for targeted-ABPP and observed a lack of GABAA receptor subunit protection.	Hydrogen	35-43	amyloid beta (A4) precursor protein	Mus musculus	108-112
33955317-6	2021	Our in-silico data clearly revealed that cystatin strongly interacts with the extracellular domain of TLR4 (binding energy=-93.5 +- 10 kJ/mol) and this biophysical interaction is mediated by hydrogen bonding and hydrophobic interaction.	Hydrogen	191-199	toll like receptor 4	Homo sapiens	102-106
21345721-4	2011	Negative values of DeltaG, DeltaH, and DeltaS indicate that the interaction between SAS and BSA is driven by hydrogen bonds and van der Waals forces.	Hydrogen	109-117	tetraspanin 31	Homo sapiens	84-87
27498775-6	2016	The mutations weakened the hydrogen bonding network between GDP/GTP and the binding pocket residues, and increased the interactions in the Galpha-Gbetagamma interface.	Hydrogen	27-35	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	139-145
21388959-6	2011	Comparison among the two structures and other state 1 and state 2 structures of H-Ras/M-Ras reveal two new structural features playing critical roles in state dynamics; interaction of residues 31/41 (H-Ras/M-Ras) with residues 29/39 and 30/40, which induces a conformational change of switch I favoring its interaction with the gamma-phosphate, and the hydrogen-bonding interaction of switch II with its neighboring alpha-helix, alpha3-helix, which induces a conformational change of switch II favoring its interaction with the gamma-phosphate.	Hydrogen	353-361	muscle RAS oncogene homolog	Homo sapiens	86-91
21388959-6	2011	Comparison among the two structures and other state 1 and state 2 structures of H-Ras/M-Ras reveal two new structural features playing critical roles in state dynamics; interaction of residues 31/41 (H-Ras/M-Ras) with residues 29/39 and 30/40, which induces a conformational change of switch I favoring its interaction with the gamma-phosphate, and the hydrogen-bonding interaction of switch II with its neighboring alpha-helix, alpha3-helix, which induces a conformational change of switch II favoring its interaction with the gamma-phosphate.	Hydrogen	353-361	HRas proto-oncogene, GTPase	Homo sapiens	200-205
21388959-6	2011	Comparison among the two structures and other state 1 and state 2 structures of H-Ras/M-Ras reveal two new structural features playing critical roles in state dynamics; interaction of residues 31/41 (H-Ras/M-Ras) with residues 29/39 and 30/40, which induces a conformational change of switch I favoring its interaction with the gamma-phosphate, and the hydrogen-bonding interaction of switch II with its neighboring alpha-helix, alpha3-helix, which induces a conformational change of switch II favoring its interaction with the gamma-phosphate.	Hydrogen	353-361	muscle RAS oncogene homolog	Homo sapiens	206-211
33784451-0	2021	Conformational Dynamics of alpha-Synuclein during the Interaction with Phospholipid Nanodiscs by Millisecond Hydrogen-Deuterium Exchange Mass Spectrometry.	Hydrogen	109-117	synuclein alpha	Homo sapiens	27-42
31204495-1	2021	To find a potent alpha-glucosidase inhibitor, 24 tyrosol derivatives with different substituents located at the meta, ortho, or para position of the phenyl group have been synthesised via the Mitsunobu reaction, characterised by 1H NMR, 13C NMR, ESI-MS and IR and evaluated for inhibition.	Hydrogen	229-231	sucrase-isomaltase	Homo sapiens	17-34
21387055-0	2011	Ionic liquid catalysed reaction of thiols with alpha,beta-unsaturated carbonyl compounds--remarkable influence of the C-2 hydrogen and the anion.	Hydrogen	122-130	complement C2	Homo sapiens	118-121
21387055-1	2011	Hydrogen bond induced reactivity and selectivity control in the 1-butyl-3-methylimidazolium based ionic liquid catalysed reaction of thiols with alpha,beta-unsaturated carbonyl compounds is reported with remarkable influence of the anion and the C-2 hydrogen in catalytic activity and reversal of selectivity.	Hydrogen	0-8	complement C2	Homo sapiens	246-249
21387055-1	2011	Hydrogen bond induced reactivity and selectivity control in the 1-butyl-3-methylimidazolium based ionic liquid catalysed reaction of thiols with alpha,beta-unsaturated carbonyl compounds is reported with remarkable influence of the anion and the C-2 hydrogen in catalytic activity and reversal of selectivity.	Hydrogen	250-258	complement C2	Homo sapiens	246-249
20949514-4	2011	The analytic potential energy function produces the equilibrium hydrogen bond distances of the MP2/6-311+G** with BSSE correction within the error limits of 0.050 A for all the 48 dimers.	Hydrogen	64-72	tryptase pseudogene 1	Homo sapiens	95-98
20949514-6	2011	The values of the binding energies and equilibrium hydrogen bond distances obtained from the analytic potential energy function are also in good agreement with those obtained from MP2 calculations with the BSSE correction.	Hydrogen	51-59	tryptase pseudogene 1	Homo sapiens	180-183
27380893-4	2016	RESULTS: Bath application of H2 S donor NaHS (50 and 100 muM) rapidly promoted surface insertion of hippocampal AMPAR GluR1 subunit.	Hydrogen	29-31	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	118-123
27380893-9	2016	H2 S increased S-sulfhydration of protein phosphatase type 2A (PP2A), which may be partially involved in the activation of signal pathways.	Hydrogen	0-2	protein phosphatase 2 phosphatase activator	Homo sapiens	63-67
27380893-10	2016	CONCLUSION: Our data suggest that H2 S promotes surface insertion of AMPARs via phosphorylation of GluR1, which depends on a sulfhydration-mediated mechanism.	Hydrogen	34-36	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	69-75
27380893-10	2016	CONCLUSION: Our data suggest that H2 S promotes surface insertion of AMPARs via phosphorylation of GluR1, which depends on a sulfhydration-mediated mechanism.	Hydrogen	34-36	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	99-104
26952193-11	2016	Moreover, because of negative values of  H  and  S * quantities, we demonstrated that van der Waals and hydrogen bonds governed the strong NPT-DR5 association for pH &gt; 7.4 (as for TRAIL alone).	Hydrogen	104-112	TNF receptor superfamily member 10b	Homo sapiens	143-146
27439590-7	2016	When the Pt to Pd atomic ratio changes from 1:0 to about 2:1, the rate of hydrogen production increases from 900 mumol/h for Pt NCs/CdS catalyst to 1837 mumol/h for Pt-Pd (2:1) NCs/CdS photocatalyst-a 104% rate increase.	Hydrogen	74-82	CDP-diacylglycerol synthase 1	Homo sapiens	132-135
27439590-7	2016	When the Pt to Pd atomic ratio changes from 1:0 to about 2:1, the rate of hydrogen production increases from 900 mumol/h for Pt NCs/CdS catalyst to 1837 mumol/h for Pt-Pd (2:1) NCs/CdS photocatalyst-a 104% rate increase.	Hydrogen	74-82	CDP-diacylglycerol synthase 1	Homo sapiens	181-184
27477237-2	2016	Herein, we report that a heterogeneous photocatalyst (Ni-modified CdS nanoparticles) could efficiently split alcohols into hydrogen and corresponding aldehydes or ketones in a stoichiometric manner under visible light irradiation.	Hydrogen	123-131	CDP-diacylglycerol synthase 1	Homo sapiens	66-69
27406067-0	2016	A highly efficient noble metal free photocatalytic hydrogen evolution system containing MoP and CdS quantum dots.	Hydrogen	51-59	opioid receptor mu 1	Homo sapiens	88-91
33891343-0	2021	One-Step Template/Solvent-Free Pyrolysis for in-situ  Immobilization of CoP Nanoparticles onto N and P co-Doped Carbon Porous Nanosheets towards High-efficiency Electrocatalytic Hydrogen Evolution.	Hydrogen	178-186	caspase recruitment domain family member 16	Homo sapiens	72-75
27406067-1	2016	We report the construction of a highly efficient noble metal free photocatalytic hydrogen (H2) evolution system using CdS quantum dots as the light absorber and metallic MoP as the cocatalyst.	Hydrogen	81-89	opioid receptor mu 1	Homo sapiens	170-173
27406067-1	2016	We report the construction of a highly efficient noble metal free photocatalytic hydrogen (H2) evolution system using CdS quantum dots as the light absorber and metallic MoP as the cocatalyst.	Hydrogen	91-93	opioid receptor mu 1	Homo sapiens	170-173
27406067-3	2016	The effect of synthesis conditions on the electrocatalytic and photocatalytic H2 evolution activity of MoP was investigated.	Hydrogen	78-80	opioid receptor mu 1	Homo sapiens	103-106
33893313-3	2021	The structure of the optical sensor is readily nano-engineered to yield extraordinarily rapid response to hydrogen gas (<3 s at 1 mbar H2) with a high degree of accuracy (<5%).	Hydrogen	106-114	gastrin	Homo sapiens	115-118
26300286-0	2016	Hydrogen bonds in Zif268 proteins - a theoretical perspective.	Hydrogen	0-8	early growth response 1	Homo sapiens	18-24
26300286-1	2016	The aim of the work was to elucidate the presence of different hydrogen bond (H-bond) in five Zif268 proteins (1A1F, 1A1G, 1A1H, 1A1I and 1A1K).	Hydrogen	63-71	early growth response 1	Homo sapiens	94-100
27376589-4	2016	The free backbone C=O groups on helices H5 and H7 stabilize the inactive rhodopsin structure through hydrogen-bonds to residues on adjacent helices.	Hydrogen	101-109	rhodopsin	Bos taurus	73-82
33933794-6	2021	The comprehensive enhancements for catalytic activity of 0.5% CoP-CN could be attributed to its reduced over-potentials, more negative photo-reductive potentials, boosted interfacial charge transfer efficiency, as well as a much higher solar to hydrogen efficiency.	Hydrogen	245-253	caspase recruitment domain family member 16	Homo sapiens	62-65
33874887-12	2021	And, the hydrogen-rich gases pretreatment improved the Hsp60 protein expression in pancreatic tissues of AP mice at 1 h and 5 h. CONCLUSIONS: Pre-inhalation of hydrogen-rich gases have a good protective effect on AP mice, and the possible mechanisms of reduced oxidative stress and the early increased pancreatic Hsp60 protein deserve attention.	Hydrogen	9-17	heat shock protein 1 (chaperonin)	Mus musculus	55-60
27251109-0	2016	Effects of the large distribution of CdS quantum dot sizes on the charge transfer interactions into TiO2 nanotubes for photocatalytic hydrogen generation.	Hydrogen	134-142	CDP-diacylglycerol synthase 1	Homo sapiens	37-40
33874887-12	2021	And, the hydrogen-rich gases pretreatment improved the Hsp60 protein expression in pancreatic tissues of AP mice at 1 h and 5 h. CONCLUSIONS: Pre-inhalation of hydrogen-rich gases have a good protective effect on AP mice, and the possible mechanisms of reduced oxidative stress and the early increased pancreatic Hsp60 protein deserve attention.	Hydrogen	9-17	heat shock protein 1 (chaperonin)	Mus musculus	313-318
27251109-2	2016	CdS quantum dots have revealed a hydrogen generation improvement when added to TiO2 materials under visible-light irradiation.	Hydrogen	33-41	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
33874887-12	2021	And, the hydrogen-rich gases pretreatment improved the Hsp60 protein expression in pancreatic tissues of AP mice at 1 h and 5 h. CONCLUSIONS: Pre-inhalation of hydrogen-rich gases have a good protective effect on AP mice, and the possible mechanisms of reduced oxidative stress and the early increased pancreatic Hsp60 protein deserve attention.	Hydrogen	160-168	heat shock protein 1 (chaperonin)	Mus musculus	55-60
27251109-3	2016	In the present paper, we investigated the performance of TiO2 nanotubes coupled with CdS quantum dots, by a molecular bifunctional linker, on photocatalytic hydrogen generation.	Hydrogen	157-165	CDP-diacylglycerol synthase 1	Homo sapiens	85-88
27251109-10	2016	The effect of the size and the distribution of sizes of CdS quantum dots attached to TiO2 nanotubes on the photocatalytic hydrogen generation were investigated.	Hydrogen	122-130	CDP-diacylglycerol synthase 1	Homo sapiens	56-59
33874887-12	2021	And, the hydrogen-rich gases pretreatment improved the Hsp60 protein expression in pancreatic tissues of AP mice at 1 h and 5 h. CONCLUSIONS: Pre-inhalation of hydrogen-rich gases have a good protective effect on AP mice, and the possible mechanisms of reduced oxidative stress and the early increased pancreatic Hsp60 protein deserve attention.	Hydrogen	160-168	heat shock protein 1 (chaperonin)	Mus musculus	313-318
27251109-11	2016	The experimental results showed three different behaviors when the reaction time of CdS synthesis was increased in the sensitized samples, i.e. similar, deactivation and activation effects on the hydrogen production with regard to TiO2 nanotubes.	Hydrogen	196-204	CDP-diacylglycerol synthase 1	Homo sapiens	84-87
33862576-9	2021	Hydrogen bonds (H-bonds) analysis was performed, and the observation suggested that the disruption of the H-bonds between MEP chains leads to an increase in the polymer matrix"s void spaces.	Hydrogen	0-8	neurolysin	Homo sapiens	122-125
27251109-14	2016	This property facilitates an improvement of the visible-light hydrogen evolution rate from zero, for TiO2 nanotubes, to approximately 0.3 mumol cm(-2) h(-1) for TiO2 nanotubes sensitized with CdS quantum dots.	Hydrogen	62-70	CDP-diacylglycerol synthase 1	Homo sapiens	192-195
33797711-0	2021	Partial magic angle spinning NMR 1H, 13C, 15N resonance assignments of the flexible regions of a monomeric alpha-synuclein: conformation of C-terminus in the lipid-bound and amyloid fibril states.	Hydrogen	33-35	synuclein alpha	Homo sapiens	107-122
27377386-5	2016	alphaHis103(G10), located in the alpha1:beta1 dimer interface, appears to be a Bohr group that undergoes structural changes: in the R state it is singly protonated/deuterated and hydrogen-bonded through a water network to betaAsn108(G10) and in the T state it is doubly protonated/deuterated with the network uncoupled.	Hydrogen	179-187	adrenoceptor alpha 1D	Homo sapiens	33-45
29474609-7	2016	Multivariate Cox analyses, incorporating diabetes, CMRI scar size, LVEF and hs-TnT levels (applied at a single hs-TnT time point) showed that 48 and 72 h hs-TnT levels were independent predictors for MACE (HR = 1.20, P = 0.002, and HR = 1.21, P = 0.035 respectively).	Hydrogen	76-78	troponin T1, slow skeletal type	Homo sapiens	79-82
33439102-0	2021	Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement via IL-10 and Sirt 1 signaling.	Hydrogen	0-8	sirtuin 1	Mus musculus	112-118
33270159-0	2021	1H, 13C, and 15N backbone chemical shift assignments of the C-terminal dimerization domain of SARS-CoV-2 nucleocapsid protein.	Hydrogen	0-2	nucleocapsid phosphoprotein	Severe acute respiratory syndrome coronavirus 2	105-117
27130146-2	2016	Inhibition of purified thioredoxin reductase (TrxR) is observed with 1 and 2 only after their enzymatic oxidation by the hydrogen peroxide/horseradish peroxidase (H2O2/HRP) system with IC50 of 2.4 and 1.2muM respectively.	Hydrogen	121-129	thioredoxin	Homo sapiens	23-34
26917446-8	2016	We find that adding weak attractive interactions between hydrogen atoms to the model is sufficient to achieve predictions for P(chi3 ) that closely match the observed P(chi3 ) distributions for Met, Nle, and Mse.	Hydrogen	57-65	chitinase 1	Homo sapiens	126-132
26917446-8	2016	We find that adding weak attractive interactions between hydrogen atoms to the model is sufficient to achieve predictions for P(chi3 ) that closely match the observed P(chi3 ) distributions for Met, Nle, and Mse.	Hydrogen	57-65	chitinase 1	Homo sapiens	167-173
33646477-9	2021	These were supported by the displacement of Asp140 and Arg136, crucial for hydrogen bond formation in Cpd1.	Hydrogen	75-83	cerebellar ataxia, infantile nonprogressive, autosomal recessive	Homo sapiens	102-106
29123834-11	2017	In vitro analysis of cytokine levels after LPS treatment of cultured macrophages showed an increase of interleukin-10 by hydrogen regardless of the presence of nitric oxide.	Hydrogen	121-129	interleukin 10	Rattus norvegicus	103-117
33723082-5	2021	Using pulse-labeling hydrogen-deuterium exchange mass spectrometry, we found that ANGPTL4 binding initiates conformational changes that are nucleated on beta3-alpha3 and progress to beta5 and beta4-alpha4, ultimately leading to the irreversible unfolding of regions that form LPL"s catalytic pocket.	Hydrogen	21-29	angiopoietin like 4	Homo sapiens	82-89
26758802-0	2016	Permanently porous hydrogen-bonded frameworks of rod-like thiophenes, selenophenes, and tellurophenes capped with MIDA boronates.	Hydrogen	19-27	NADH:ubiquinone oxidoreductase complex assembly factor 7	Homo sapiens	114-118
26758802-1	2016	Permanently porous hydrogen-bonded organic frameworks comprising rod-like molecules with two MIDA boronate termini have been prepared.	Hydrogen	19-27	NADH:ubiquinone oxidoreductase complex assembly factor 7	Homo sapiens	93-97
26758802-2	2016	We show that MIDA boronates self-assemble through multiple hydrogen-bonding interactions.	Hydrogen	59-67	NADH:ubiquinone oxidoreductase complex assembly factor 7	Homo sapiens	13-17
27146428-3	2016	The CoP/TM electrode delivers 10 mA cm(-2) at an overpotential of 72 mV for the hydrogen evolution reaction (HER) and 310 mV for the oxygen evolution reaction (OER) in 1.0 M KOH.	Hydrogen	80-88	caspase recruitment domain family member 16	Homo sapiens	4-7
33438321-0	2021	Single atom Ru doped CoP/CDs Nanosheets via Splicing of Carbon-Dots for Robust Hydrogen Production.	Hydrogen	79-87	caspase recruitment domain family member 16	Homo sapiens	21-24
33751377-0	2021	1H, 15N and 13C backbone and side-chain assignments of reduced and S-nitrosated C62only mutant of human thioredoxin.	Hydrogen	0-2	thioredoxin	Homo sapiens	104-115
27258022-7	2016	Moreover, we determined the salt bridges, hydrogen bonds and hydrophobic interactions in the Impalpha-NplNLS interface.	Hydrogen	42-50	inositol monophosphatase 1	Homo sapiens	93-101
33577685-8	2021	The steric constraints of the bicyclic 2"-F-NMC may impair formation of hydrogen-bonding interactions between the vinylphosphonate and the MID domain of Ago2.	Hydrogen	72-80	argonaute RISC catalytic subunit 2	Mus musculus	153-157
27114072-1	2016	The reaction of Fe(eta-C5H4NHC(O)PPh2)2 () with PtX2(PPh3)2 selectively formed cage-shaped complexes formulated as [(PtX)4()6]X4 CHCl3 (X = Cl, Br), in which the four square-planar Pt fragments were situated at each vertex and the six s were located in each side of a tetrahedral framework and hydrogen bonds existed between the NH groups in s and X(-) ions inside the cage.	Hydrogen	294-302	protein phosphatase 4 catalytic subunit	Homo sapiens	53-57
33310319-2	2021	The recognition properties of GH towards H2S/GSH were satisfactorily demonstrated through fluorescence, UV-vis, 1H NMR and DFT calculations.	Hydrogen	112-114	gamma-glutamyl hydrolase	Homo sapiens	30-32
27181158-2	2016	The coupled cluster, MP2 and DFT methods yield comparable results and show that anions have very high capacity to store hydrogen as the weight percent of H2 in the highest H2-coordinated state of F(-), Cl(-), Br(-), OH(-), NH2(-), NO2(-), CN(-), and ClO(-) is 56.0, 47.6, 33.5, 64.0, 65.4, 41.2, 55.4, and 40.0 wt%, respectively.	Hydrogen	120-128	tryptase pseudogene 1	Homo sapiens	21-24
26934039-0	2016	Mo2 C as Non-Noble Metal Co-Catalyst in Mo2 C/CdS Composite for Enhanced Photocatalytic H2 Evolution under Visible Light Irradiation.	Hydrogen	88-90	CDP-diacylglycerol synthase 1	Homo sapiens	46-49
26934039-2	2016	Here, we reported a new non-noble-metal co-catalyst Mo2 C that efficiently improves the photocatalytic H2 evolution of CdS under visible light irradiation.	Hydrogen	103-105	CDP-diacylglycerol synthase 1	Homo sapiens	119-122
33715135-8	2021	Crystal structure analysis showed that the three residues affected by the novel in-frame deletion form several hydrogen bonds that could lead to impaired stability and function of the CYP21A2 protein.	Hydrogen	111-119	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	184-191
26965860-6	2016	The data also suggest that, similar to another bacterial OdG repair enzyme, MutM, a specific carbonyl in the enzyme can not only promote activity by forming an active site hydrogen bond with the N7-hydrogen of OdGTP, but can also hinder activity through electrostatic repulsion with the N7-lone pair of dGTP.	Hydrogen	172-180	8-oxoguanine DNA glycosylase	Homo sapiens	76-80
26965860-6	2016	The data also suggest that, similar to another bacterial OdG repair enzyme, MutM, a specific carbonyl in the enzyme can not only promote activity by forming an active site hydrogen bond with the N7-hydrogen of OdGTP, but can also hinder activity through electrostatic repulsion with the N7-lone pair of dGTP.	Hydrogen	198-206	8-oxoguanine DNA glycosylase	Homo sapiens	76-80
27081066-0	2016	Nuclear quantum effects of hydrogen bonds probed by tip-enhanced inelastic electron tunneling.	Hydrogen	27-35	TOR signaling pathway regulator	Homo sapiens	52-55
27081066-1	2016	We report the quantitative assessment of nuclear quantum effects on the strength of a single hydrogen bond formed at a water-salt interface, using tip-enhanced inelastic electron tunneling spectroscopy based on a scanning tunneling microscope.	Hydrogen	93-101	TOR signaling pathway regulator	Homo sapiens	147-150
27081066-2	2016	The inelastic scattering cross section was resonantly enhanced by "gating" the frontier orbitals of water via a chlorine-terminated tip, so the hydrogen-bonding strength can be determined with high accuracy from the red shift in the oxygen-hydrogen stretching frequency of water.	Hydrogen	144-152	TOR signaling pathway regulator	Homo sapiens	132-135
27067258-8	2016	The first substitution was predicted to eliminate a hydrogen bond and alter the tertiary structure of lebercilin, protein encoded by LCA5.	Hydrogen	52-60	lebercilin LCA5	Homo sapiens	102-112
26869098-0	2016	Synthesis of octahedral, truncated octahedral, and cubic Rh2Ni nanocrystals and their structure-activity relationship for the decomposition of hydrazine in aqueous solution to hydrogen.	Hydrogen	176-184	Rh associated glycoprotein	Homo sapiens	57-60
27053034-3	2016	Metal ion-chelated linear PEIs were applied as a heterofunctional framework for glycerol dehydrogenase (GDH) immobilization by hydrogen bonds, electrostatic forces and coordination bonds interactions.	Hydrogen	91-99	glutamate dehydrogenase 1	Homo sapiens	104-107
26373425-0	2016	1H, 15N and 13C backbone assignments of GDP-bound human H-Ras mutant G12V.	Hydrogen	0-2	HRas proto-oncogene, GTPase	Homo sapiens	56-61
26377205-0	2016	1H, 15N and 13C assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques.	Hydrogen	0-2	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	56-61
26386961-0	2016	15N, 13C and 1H backbone resonance assignments of an artificially engineered TEM-1/PSE-4 class A beta-lactamase chimera and its deconvoluted mutant.	Hydrogen	13-15	CD248 molecule	Homo sapiens	77-82
26880801-7	2016	In particular, docking predictions suggested that three notable hydrogen bonds between talniflumate and GCNT3 contribute to a docking affinity of -8.3 kcal/mol.	Hydrogen	64-72	glucosaminyl (N-acetyl) transferase 3, mucin type	Homo sapiens	104-109
26808198-7	2016	Itk and Btk SH3 underwent a clear EX1 cooperative unfolding event, which was localized using pepsin digestion and mass spectrometry after hydrogen exchange labeling.	Hydrogen	138-146	IL2 inducible T cell kinase	Homo sapiens	0-3
26812210-10	2016	A p53-derived peptide binds with high affinity (Kd value of 150nM) and causes the formation of an extensive network of hydrogen bonds within MdmX; this constitutes the induction of order within MdmX through ligand binding.	Hydrogen	119-127	MDM4 regulator of p53	Homo sapiens	141-145
26812210-10	2016	A p53-derived peptide binds with high affinity (Kd value of 150nM) and causes the formation of an extensive network of hydrogen bonds within MdmX; this constitutes the induction of order within MdmX through ligand binding.	Hydrogen	119-127	MDM4 regulator of p53	Homo sapiens	194-198
26812210-11	2016	In contrast, the compounds bind more weakly (Kd values from 600nM to 12muM) and induce an incomplete hydrogen bond network within MdmX.	Hydrogen	101-109	MDM4 regulator of p53	Homo sapiens	130-134
26453905-4	2016	Based on the target-catalyzed hairpin assembly, target miR-21 could trigger the hybridization of H1 and H2 to further be released for initiating the next hybridization process to capture a large number of H2 bioconjugates on the sensing surface.	Hydrogen	104-106	microRNA 21	Homo sapiens	55-61
27231722-7	2016	1H MRS measurements revealed a 5.5+-13.8% increase in the dorsomedial prefrontal cortex (DMPFC) tCr levels in the tamoxifen group and a 5.3+-13.1% decrease in tCr in the placebo group (p=0.027).	Hydrogen	0-2	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	96-99
27231722-7	2016	1H MRS measurements revealed a 5.5+-13.8% increase in the dorsomedial prefrontal cortex (DMPFC) tCr levels in the tamoxifen group and a 5.3+-13.1% decrease in tCr in the placebo group (p=0.027).	Hydrogen	0-2	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	159-162
26714124-0	2016	Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy.	Hydrogen	0-8	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	95-98
26714124-3	2016	The present study aimed to explore the role of p53-mediated autophagy in the protective effect of hydrogen-rich saline (HRS) on AKI after orthotropic liver transplantation (OLT).	Hydrogen	98-106	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	47-50
26745558-2	2016	Herein, SePPh2H, HPPh2, and RNH2 act as hydrogen/proton donors with a decreased capacity, leading to the release of oleic acid (RCOOH).	Hydrogen	40-48	NLR family pyrin domain containing 4	Homo sapiens	28-32
26889829-9	2016	The structural variation of EF2 is related to these differences in the structural fluctuation and the number of the hydrogen bonds (H-bonds).	Hydrogen	116-124	eukaryotic translation elongation factor 2	Homo sapiens	28-31
26958636-4	2016	The data indicates that one hCx46 molecule forms 5-7 hydrogen bonds (HBs) with the counterpart connexin of the opposing connexon.	Hydrogen	53-61	gap junction protein alpha 3	Homo sapiens	28-33
26774338-5	2016	Using Xenopus egg extracts, we demonstrate here that abrogation of the interaction between the RFTS and the catalytic center of DNMT1, by deletion of the C-terminal portion or disruption of the hydrogen bond, results in non-ubiquitylated histone H3 binding and abnormal accumulation of DNMT1 on the chromatin.	Hydrogen	194-202	DNA methyltransferase 1 S homeolog	Xenopus laevis	128-133
26865227-0	2016	BAX inhibitor-1 enhances cancer metastasis by altering glucose metabolism and activating the sodium-hydrogen exchanger: the alteration of mitochondrial function.	Hydrogen	100-108	transmembrane BAX inhibitor motif containing 6	Homo sapiens	0-15
26806311-10	2016	Y306F HDAC8 is 150-fold less active than the wild-type enzyme; crystal structures show that Y306 hydrogen bonds with the zinc-bound substrate carbonyl, poised for transition state stabilization.	Hydrogen	97-105	histone deacetylase 8	Homo sapiens	6-11
26222672-8	2016	It also led to biohydrogenation of unsaturated FAME to more desirable saturated FAME (especially to C16:0 and C18:0), and the degree of saturation was inversely related to the accumulation of hydrogen gas after fermentation.	Hydrogen	18-26	benign adult familial myoclonic epilepsy 1	Homo sapiens	47-51
26222672-8	2016	It also led to biohydrogenation of unsaturated FAME to more desirable saturated FAME (especially to C16:0 and C18:0), and the degree of saturation was inversely related to the accumulation of hydrogen gas after fermentation.	Hydrogen	18-26	benign adult familial myoclonic epilepsy 1	Homo sapiens	80-84
26755582-2	2016	Recently, a high-resolution crystal structure of human mPGES-1 was presented, with Ser-127 being proposed as the hydrogen-bond donor stabilizing thiolate anion formation within the cofactor, glutathione (GSH).	Hydrogen	113-121	prostaglandin E synthase	Mus musculus	55-62
26661031-0	2016	TiO2/CdS porous hollow microspheres rapidly synthesized by salt-assistant aerosol decomposition method for excellent photocatalytic hydrogen evolution performance.	Hydrogen	132-140	CDP-diacylglycerol synthase 1	Homo sapiens	5-8
26661031-1	2016	TiO2/CdS porous hollow microspheres have been one-pot rapidly synthesized by a salt-assisted aerosol decomposition method, and exhibit an excellent photocatalytic activity of 996 mumol h(-1) (50 mg photocatalysts with loading Ru co-catalyst) for hydrogen evolution from aqueous solutions containing sacrificial reagents (SO3(2-) and S(2-)) under visible light (lambda &gt;= 420 nm).	Hydrogen	246-254	CDP-diacylglycerol synthase 1	Homo sapiens	5-8
26642377-0	2016	Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.	Hydrogen	10-18	indoleamine 2,3-dioxygenase 1	Homo sapiens	36-65
26642377-0	2016	Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.	Hydrogen	10-18	indoleamine 2,3-dioxygenase 1	Homo sapiens	67-71
26642377-0	2016	Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.	Hydrogen	10-18	indoleamine 2,3-dioxygenase 1	Homo sapiens	160-164
26642377-5	2016	Most interestingly, 24 formed an extensive hydrogen bond network with IDO1, which is a distinct feature of IDO1/24 complex structure and is not observed in the other IDO1 complex structures.	Hydrogen	43-51	indoleamine 2,3-dioxygenase 1	Homo sapiens	70-74
26642377-5	2016	Most interestingly, 24 formed an extensive hydrogen bond network with IDO1, which is a distinct feature of IDO1/24 complex structure and is not observed in the other IDO1 complex structures.	Hydrogen	43-51	indoleamine 2,3-dioxygenase 1	Homo sapiens	107-111
26642377-5	2016	Most interestingly, 24 formed an extensive hydrogen bond network with IDO1, which is a distinct feature of IDO1/24 complex structure and is not observed in the other IDO1 complex structures.	Hydrogen	43-51	indoleamine 2,3-dioxygenase 1	Homo sapiens	107-111
26600404-8	2016	Strong hydrogen bonds between (alpha1 + alpha2) and alpha3 differ between SC1 and SC2 but are nearly invariant within each SC.	Hydrogen	7-15	adrenoceptor alpha 1D	Homo sapiens	31-46
27294143-7	2016	Our analyses suggested that the aforementioned variants especially H341Y could directly or indirectly destabilize the amino acid interactions and hydrogen bonding networks of ADIPOR1.	Hydrogen	146-154	adiponectin receptor 1	Homo sapiens	175-182
20544238-1	2011	The nature of the lithium/hydrogen bonding between (CH(2))(2)X(X: C=CH(2), O, S) and LiY/HY(Y=F, Cl, Br) have been theoretically investigated at MP2/6-311++G (d, p) level, using Bader"s "atoms in molecules (AIM)" theory and Weinhold"s "natural bond orbital (NBO)" methodology.	Hydrogen	26-34	tryptase pseudogene 1	Homo sapiens	145-148
21295090-6	2011	Computer modeling verified that MT1-AF7p binds to the MT-loop region of MT1-MMP and interacts with MT1-MMP through hydrogen bonding and hydrophobic interactions.	Hydrogen	115-123	metallothionein 1I, pseudogene	Homo sapiens	32-35
21237148-5	2011	Pretreatment with IL-10 (10-100ng, intracerebroventricularly) 1h before intravenous LPS significantly reduced the LPS-induced changes in extracellular glutamate, hydroxyl radicals, and PGE(2) in the hypothalamus and fever, but not the increased levels of TNF-alpha in rabbits.	Hydrogen	62-64	tumor necrosis factor	Oryctolagus cuniculus	255-264
21178106-8	2011	Trafficking of alpha(1H)-GFP was also disrupted by cotransfection of HEK-293 cells with the dominant-negative form of ADP-ribosylation factor (ARF)1 but not ARF6, suggesting that ARF1 regulates the LIF-evoked membrane trafficking of alpha(1H)-GFP subunits.	Hydrogen	21-23	LIF interleukin 6 family cytokine	Homo sapiens	198-201
21279630-4	2011	In addition, oxidation products formed by alkoxyl rearrangement reactions with cleavage of the peptide chain were also identified for GH, GHG, and GGH, corroborating hydrogen abstraction step in G residues.	Hydrogen	166-174	gamma-glutamyl hydrolase	Homo sapiens	147-150
21626786-2	2011	All of them were new compounds, and their structures were confirmed by 1H NMR and HR-MS. Three compounds exhibited higher agonistic activities of PPARgamma than that of the comparison, six compounds exhibited higher agonistic activities of PPARalpha than that of the comparison, and compound 8a was discovered as a highly potent PPARalpha/gamma agonist that is much more active than that of WY14643 and rosiglitazone.	Hydrogen	71-73	peroxisome proliferator activated receptor alpha	Homo sapiens	240-249
21272566-0	2011	Sensitive non-radioactive determination of aminotransferase stereospecificity for C-4" hydrogen transfer on the coenzyme.	Hydrogen	87-95	complement C4A (Rodgers blood group)	Homo sapiens	82-85
21272566-1	2011	A sensitive non-radioactive method for determination of the stereospecificity of the C-4" hydrogen transfer on the coenzymes (pyridoxal phosphate, PLP; and pyridoxamine phosphate, PMP) of aminotransferases has been developed.	Hydrogen	90-98	complement C4A (Rodgers blood group)	Homo sapiens	85-88
21272566-5	2011	The (2)H at C-4" is retained with the PLP if the aminotransferase in question transfers C-4" hydrogen on the opposite face of the coenzyme compared with the reference aminotransferase, but the (2)H is removed if the test and reference aminotransferases catalyze hydrogen transfer on the same face.	Hydrogen	93-101	complement C4A (Rodgers blood group)	Homo sapiens	12-15
21272566-5	2011	The (2)H at C-4" is retained with the PLP if the aminotransferase in question transfers C-4" hydrogen on the opposite face of the coenzyme compared with the reference aminotransferase, but the (2)H is removed if the test and reference aminotransferases catalyze hydrogen transfer on the same face.	Hydrogen	93-101	complement C4A (Rodgers blood group)	Homo sapiens	88-91
21272566-5	2011	The (2)H at C-4" is retained with the PLP if the aminotransferase in question transfers C-4" hydrogen on the opposite face of the coenzyme compared with the reference aminotransferase, but the (2)H is removed if the test and reference aminotransferases catalyze hydrogen transfer on the same face.	Hydrogen	262-270	complement C4A (Rodgers blood group)	Homo sapiens	12-15
21272566-5	2011	The (2)H at C-4" is retained with the PLP if the aminotransferase in question transfers C-4" hydrogen on the opposite face of the coenzyme compared with the reference aminotransferase, but the (2)H is removed if the test and reference aminotransferases catalyze hydrogen transfer on the same face.	Hydrogen	262-270	complement C4A (Rodgers blood group)	Homo sapiens	88-91
21280108-6	2011	The linear dependence of k(et) on proton concentration together with the observed inverse kinetic isotope effect suggests that proton-coupled electron transfer from Acr -Mes to PtNPs to form the Pt-H bond is the rate-determining step for catalytic hydrogen evolution.	Hydrogen	248-256	acrosin	Homo sapiens	165-168
21280108-7	2011	When FeNPs were used instead of PtNPs, hydrogen evolution was also observed, although the hydrogen-evolution efficiency was significantly lower than that of PtNPs because of the much slower electron transfer from Acr -Mes to FeNPs.	Hydrogen	39-47	acrosin	Homo sapiens	213-216
21280108-7	2011	When FeNPs were used instead of PtNPs, hydrogen evolution was also observed, although the hydrogen-evolution efficiency was significantly lower than that of PtNPs because of the much slower electron transfer from Acr -Mes to FeNPs.	Hydrogen	90-98	acrosin	Homo sapiens	213-216
20658568-7	2011	The interhydrogen-bonds at the protein-DNA interface and the induced intrafinger hydrogen bonds between the residues of protein for the Zif268-DNA complex have been identified at some key contact sites.	Hydrogen	9-17	early growth response 1	Homo sapiens	136-142
21112087-3	2011	At a 5mug/kg dose administered 1h prior to challenge with human chorionic gonadotropin (hCG, 1.0 U/kg, iv), NPY significantly (P&lt;0.01) blunted the T response to this gonadotropin.	Hydrogen	31-33	neuropeptide Y	Homo sapiens	108-111
21241135-5	2011	Interestingly, additional H(2) molecules can be bound to the carbon atoms at the chain ends due to the charge transfer between Li 2s2p (Na 3s) and C 2p states.	Hydrogen	26-30	complement C2	Homo sapiens	147-151
21049972-10	2011	Hydrogen-deuterium exchange mass spectroscopy indicates GRIP-1 binding to hRXRalpha-LBD:9cRA significantly decreases the exchange rates for peptides containing helices 3 (F277), 4 (R302), 11 (F437), and 12 (E453, E456).	Hydrogen	0-8	glutamate receptor interacting protein 1	Homo sapiens	56-62
20943666-3	2010	A six-residue insertion between strands beta(1) and beta(2) of the hMSL3 chromo-barrel domain directs the side chain of Glu-21 into the methyllysine binding pocket where it hydrogen bonds to the NH group of a bound cyclohexylamino ethanesulfonate buffer molecule, likely mimicking interactions with a histone tail dimethyllysine residue.	Hydrogen	173-181	MSL complex subunit 3	Homo sapiens	67-72
20816729-8	2010	Expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and chemokine (MIP-1alpha) in lung showed an increase from 1h to 24h after instillation and recovered thereafter.	Hydrogen	132-134	chemokine (C-C motif) ligand 3	Mus musculus	88-98
20839301-9	2010	Disappearance of the hydrogen bond between K helix and beta4 loop was observed in CYP2C9*5.	Hydrogen	21-29	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	82-88
20886156-2	2010	In rhodopsin, ECL2 forms a rigid structure including a beta-sheet and interacts with the transmembrane region via a disulfide bond, hydrogen bonds, and hydrophobic interactions.	Hydrogen	132-140	rhodopsin	Bos taurus	3-12
20886866-4	2010	The BChE mutants with at least ~1000-fold improved catalytic efficiency against (-)-cocaine compared to the wild-type BChE are all associated with the TS1 structures having stronger overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxyanion hole of the enzyme.	Hydrogen	190-198	butyrylcholinesterase	Homo sapiens	4-8
20886866-4	2010	The BChE mutants with at least ~1000-fold improved catalytic efficiency against (-)-cocaine compared to the wild-type BChE are all associated with the TS1 structures having stronger overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxyanion hole of the enzyme.	Hydrogen	190-198	butyrylcholinesterase	Homo sapiens	118-122
20959106-3	2010	Contrary to the results of crystallographic studies, our results show that there are multiple dynamic hydrogen bonds and salt bridges in the cyt c-c1 interface.	Hydrogen	102-110	C-C motif chemokine ligand 14	Homo sapiens	145-149
20947024-4	2010	Both RRM1 in RRM1-RNA and RRM2 in RRM1/2-RNA complexes use similar principles to target UGU(U/G) elements, with recognition mediated by face-to-edge stacking and water-mediated hydrogen-bonding networks.	Hydrogen	177-185	ribonucleotide reductase regulatory subunit M2	Homo sapiens	26-30
26616766-5	2010	The performance of this algorithm has been tested for the CH4/CD3H/CD4 + CF3 hydrogen abstraction reactions with encouraging results, i.e., when the fitting is performed using 13 points, the algorithm is about 30 times faster than the full calculation with deviations that are smaller than 5%.	Hydrogen	77-85	CD247 molecule	Homo sapiens	62-66
20949041-0	2010	1H-NMR-based metabolomic profiling of CSF in early amyotrophic lateral sclerosis.	Hydrogen	0-2	colony stimulating factor 2	Homo sapiens	38-41
20526701-0	2010	1H, 13C and 15N resonance assignments of human H-REV107 N-terminal domain.	Hydrogen	0-2	phospholipase A and acyltransferase 1	Homo sapiens	47-55
20526825-0	2010	Backbone 1H, 13C and 15N resonance assignments of the extracellular domain of tissue factor.	Hydrogen	9-11	coagulation factor III, tissue factor	Homo sapiens	78-91
20554199-2	2010	The CSTR was operated at an hydraulic retention time (HRT) of 3 days, and the UASB and AF reactors were operated at 1 day HRT, using mixed extreme thermophiles at 70  C. The highest hydrogen production yield of 212.0+-6.6 mL-H2/g-sugars, corresponding to a hydrogen production rate of 821.4+-25.5 mL-H2/dL was achieved with the UASB reactor.	Hydrogen	182-190	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	222-227
20617400-0	2010	1H, 13C and 15N resonance assignments of the human mesencephalic astrocyte-derived neurotrophic factor.	Hydrogen	0-2	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	51-102
20617402-0	2010	NMR assignment of 1H, 13C, and 15N resonances of rat lipocalin-type prostaglandin D synthase.	Hydrogen	18-20	prostaglandin D2 synthase	Rattus norvegicus	53-92
20423075-0	2010	Solar light-responsive Pt/CdS/TiO2 photocatalysts for hydrogen production and simultaneous degradation of inorganic or organic sacrificial agents in wastewater.	Hydrogen	54-62	CDP-diacylglycerol synthase 1	Homo sapiens	26-29
20660185-5	2010	On average, unliganded core gp120 displayed &gt;10,000-fold slower exchange of backbone-amide hydrogens than a theoretically unstructured protein of the same composition, with binding by CD4 reducing the rate of gp120 amide exchange a further 10-fold.	Hydrogen	94-103	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	28-33
20660185-5	2010	On average, unliganded core gp120 displayed &gt;10,000-fold slower exchange of backbone-amide hydrogens than a theoretically unstructured protein of the same composition, with binding by CD4 reducing the rate of gp120 amide exchange a further 10-fold.	Hydrogen	94-103	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	212-217
20823678-6	2010	A minimum reactive system comprising hSRD5A2 and testosterone (T) as substrate together with NADPH as hydrogen donor was established for screening inhibitors of hSRD5A2.	Hydrogen	102-110	steroid 5 alpha-reductase 2	Homo sapiens	161-168
20715287-9	2010	The stabilizing role of PEG on TEPA/SiO(2) can be attributed to hydrogen-bonding between TEPA (NH(2)/NH)and PEG (OH).	Hydrogen	64-72	progestagen associated endometrial protein	Homo sapiens	24-27
20715287-9	2010	The stabilizing role of PEG on TEPA/SiO(2) can be attributed to hydrogen-bonding between TEPA (NH(2)/NH)and PEG (OH).	Hydrogen	64-72	progestagen associated endometrial protein	Homo sapiens	108-111
20698690-1	2010	Structural, spectroscopic, and electronic features of weak hydrogen-bonded complexes of CpM(CO)(3)H (M = Mo (1a), W (1b)) hydrides with organic bases (phosphine oxides R(3)PO (R = n-C(8)H(17), NMe(2)), amines NMe(3), NEt(3), and pyridine) are determined experimentally (variable temperature IR) and computationally (DFT/M05).	Hydrogen	59-67	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	193-199
20698690-1	2010	Structural, spectroscopic, and electronic features of weak hydrogen-bonded complexes of CpM(CO)(3)H (M = Mo (1a), W (1b)) hydrides with organic bases (phosphine oxides R(3)PO (R = n-C(8)H(17), NMe(2)), amines NMe(3), NEt(3), and pyridine) are determined experimentally (variable temperature IR) and computationally (DFT/M05).	Hydrogen	59-67	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	209-215
20305288-3	2010	The intestinal infusion of TCA into the CBF rat rapidly (1h) activated the AKT (approximately 9-fold) and ERK1/2 (3- to 5-fold) signaling pathways, downregulated (approximately 50%, 30 min) the mRNA levels of PEPCK and G-6-Pase, and induced (14-fold in 3 h) SHP mRNA.	Hydrogen	57-59	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	219-227
20305288-3	2010	The intestinal infusion of TCA into the CBF rat rapidly (1h) activated the AKT (approximately 9-fold) and ERK1/2 (3- to 5-fold) signaling pathways, downregulated (approximately 50%, 30 min) the mRNA levels of PEPCK and G-6-Pase, and induced (14-fold in 3 h) SHP mRNA.	Hydrogen	57-59	nuclear receptor subfamily 0, group B, member 2	Rattus norvegicus	258-261
20550105-3	2010	The structures of the LUSH-alcohol complexes identify a set of specific hydrogen-bonding interactions as critical for optimal binding of ethanol.	Hydrogen	72-80	lush	Drosophila melanogaster	22-26
20527993-6	2010	According to the model, of the 10 gp120 amino acids that showed a reduction in the level of binding when mutated to alanine, all of them are modeled as making direct contact with B40t77 as part of a hydrogen bonding network.	Hydrogen	199-207	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	34-39
20486657-5	2010	As a result, the interaction between the glutaconyl carboxylate and the guanidinium group of a conserved arginine is stronger in GDH(Des) (short and planar bidentate hydrogen bond) than in the decarboxylating human GDH (longer and monodentate hydrogen bond), which is corroborated by molecular dynamics studies.	Hydrogen	166-174	glutamate dehydrogenase 1	Homo sapiens	129-132
20486657-5	2010	As a result, the interaction between the glutaconyl carboxylate and the guanidinium group of a conserved arginine is stronger in GDH(Des) (short and planar bidentate hydrogen bond) than in the decarboxylating human GDH (longer and monodentate hydrogen bond), which is corroborated by molecular dynamics studies.	Hydrogen	166-174	glutamate dehydrogenase 1	Homo sapiens	215-218
20486657-5	2010	As a result, the interaction between the glutaconyl carboxylate and the guanidinium group of a conserved arginine is stronger in GDH(Des) (short and planar bidentate hydrogen bond) than in the decarboxylating human GDH (longer and monodentate hydrogen bond), which is corroborated by molecular dynamics studies.	Hydrogen	243-251	glutamate dehydrogenase 1	Homo sapiens	129-132
20548380-0	2010	Optical fiber tip acoustic resonator for hydrogen sensing.	Hydrogen	41-49	TOR signaling pathway regulator	Homo sapiens	14-17
20548380-1	2010	A microscale acoustic resonator fabricated on a standard single-mode fiber tip was demonstrated as a hydrogen sensor.	Hydrogen	101-109	TOR signaling pathway regulator	Homo sapiens	75-78
20235109-0	2010	Tip-enhanced Raman spectroscopic studies of the hydrogen bonding between adenine and thymine adsorbed on Au (111).	Hydrogen	48-56	TOR signaling pathway regulator	Homo sapiens	0-3
29861975-0	2016	Synthesis, structure and reactivity of a terminal magnesium fluoride compound, [TpBut,Me]MgF: hydrogen bonding, halogen bonding and C-F bond formation.	Hydrogen	94-102	signal transducer and activator of transcription 5A	Homo sapiens	89-92
29861975-7	2016	In accord with the highly polarized Mg-F bond, the fluoride ligand of [TpBut,Me]MgF is capable of serving as a hydrogen bond and halogen bond acceptor, such that it forms adducts with indole and C6F5I.	Hydrogen	111-119	signal transducer and activator of transcription 5A	Homo sapiens	80-83
26264861-7	2016	All these calculated active residues, active atoms, and hydrogen bonds are in good agreement with recorded laboratory experiments and provide guidelines for designing new ligands of CypA.	Hydrogen	56-64	peptidylprolyl isomerase A	Homo sapiens	182-186
26833077-9	2016	The compound forms strong hydrogen bonding at the peripheral anionic site of AChE whereas on BChE, it had hydrophobic and mild polar interactions.	Hydrogen	26-34	butyrylcholinesterase	Homo sapiens	93-97
33306263-5	2021	DFT calculations decipher that heterointerfaces simultaneously optimize the hydrogen adsorption free energy ( GH*) and promote the hydrazine dehydrogenation kinetics.	Hydrogen	76-84	gamma-glutamyl hydrolase	Homo sapiens	110-113
26675747-3	2015	H2O and CO2 delivered to the CMB by subducting slabs provide a source for hydrogen and carbon.	Hydrogen	74-82	complement C2	Homo sapiens	0-11
20197103-3	2010	To further elucidate the mechanism, we showed that activated H2(d) ALAK cells (adherent lymphokine activated killer, IL-2 activated T cell-depleted bone marrow and spleen cells) from BALB/c mice significantly suppressed the proliferation of H2(b) splenocytes from C57BL/6 mice in mixed lymphocyte responses (MLR) stimulated with irradiated H2(d) splenocytes from BALB/c mice (P &lt; .01).	Hydrogen	61-63	interleukin 2	Mus musculus	117-121
20197103-3	2010	To further elucidate the mechanism, we showed that activated H2(d) ALAK cells (adherent lymphokine activated killer, IL-2 activated T cell-depleted bone marrow and spleen cells) from BALB/c mice significantly suppressed the proliferation of H2(b) splenocytes from C57BL/6 mice in mixed lymphocyte responses (MLR) stimulated with irradiated H2(d) splenocytes from BALB/c mice (P &lt; .01).	Hydrogen	241-243	interleukin 2	Mus musculus	117-121
20197103-3	2010	To further elucidate the mechanism, we showed that activated H2(d) ALAK cells (adherent lymphokine activated killer, IL-2 activated T cell-depleted bone marrow and spleen cells) from BALB/c mice significantly suppressed the proliferation of H2(b) splenocytes from C57BL/6 mice in mixed lymphocyte responses (MLR) stimulated with irradiated H2(d) splenocytes from BALB/c mice (P &lt; .01).	Hydrogen	241-243	interleukin 2	Mus musculus	117-121
33097343-5	2021	In consequence, the optimal CdS/NH2-MIL-125(Ti) nanocomposites exhibit excellent photocatalytic performance with hydrogen evolution rate of 6.62 mmol h-1 g-1 under visible light illumination, which was 3.5 times higher than that of the pristine CdS.	Hydrogen	113-121	CDP-diacylglycerol synthase 1	Homo sapiens	28-31
26565704-0	2015	Hydrogen-Rich Saline Attenuates Lipopolysaccharide-Induced Heart Dysfunction by Restoring Fatty Acid Oxidation in Rats by Mitigating C-Jun N-Terminal Kinase Activation.	Hydrogen	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	133-156
33279692-0	2021	Integrating Ru-modulated CoP nanosheets binary co-catalyst with 2D g-C3N4 nanosheets for enhanced photocatalytic hydrogen evolution activity.	Hydrogen	113-121	caspase recruitment domain family member 16	Homo sapiens	25-28
26488609-8	2015	Similarly, inactivating mutations within the PKR dimer interface that disrupt key electrostatic and hydrogen binding interactions fail to abolish dimerization.	Hydrogen	100-108	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	45-48
33279692-2	2021	Herein, we report a 2D/2D Ru-modulated CoP nanosheets (Ru-CoP-x, where x refers the Ru-to-Co molar ratio)/g-C3N4 nanosheets (GCN NSs) ternary hybrid as a photocatalyst for hydrogen evolution under visible light.	Hydrogen	172-180	caspase recruitment domain family member 16	Homo sapiens	39-42
33279692-3	2021	The optimal photocatalyst 25% Ru-CoP-1:8/GCN NSs exhibits an excellent hydrogen evolution rate of 1172.5 micromol g-1 h-1 under visible light with a high apparent quantum efficiency (AQE) of 3.49% at 420 nm, which is close to Pt/g-C3N4 photocatalytic system and higher than most reported transition metal phosphides (TMP)/g-C3N4 photocatalytic system.	Hydrogen	71-79	caspase recruitment domain family member 16	Homo sapiens	33-38
33279692-4	2021	Experimental results indicate that the higher photocatalytic hydrogen evolution performance can be mainly attributed to the binary Ru-CoP-x co-catalyst with efficient charge separation and promoted surface water reduction kinetics, and the 2D/2D self-assembly structure with strong interface Schottky effect and short charge transport distance.	Hydrogen	61-69	caspase recruitment domain family member 16	Homo sapiens	134-137
26256388-4	2015	Our results showed the possibility of tailoring these properties by changing component ratios, since different interactions occurred between Chit/Col: samples with Chit-enriched compositions showed a hydrogen-bonding type complex (HC), whereas a self-crosslinking phenomenon was induced in Col-enriched scaffolds.	Hydrogen	200-208	chitinase 1	Homo sapiens	164-168
33637719-5	2021	In this work, an impressive hydrogen production rate up to 220.74 mumol h-1 cm-2 in the particulate photocatalytic systems has been achieved based on the wood/CoO system, demonstrating that the photothermal-photocatalytic biphase system is cost-effective and greatly advantageous for practical applications.	Hydrogen	28-36	H1.5 linker histone, cluster member	Homo sapiens	72-80
26351032-9	2015	These findings demonstrate that cardiomyocyte-specific mineralocorticoid receptor-dependent signaling contributes to electromechanical vulnerability in acute ischemia-reperfusion via a mechanism involving Ca(2+)/calmodulin protein kinase II activation in association with upstream alteration in expression regulation of the sodium hydrogen exchanger-1.	Hydrogen	331-339	nuclear receptor subfamily 3, group C, member 2	Mus musculus	55-81
33444457-4	2021	Utilizing hydrogen-deuterium exchange mass spectrometry (HDX-MS), we assessed the ssDNA-driven dynamics of the individual domains of human RPA.	Hydrogen	10-18	replication protein A1	Homo sapiens	139-142
26289383-6	2015	Molecular modeling and experimental MS results for [Z-PG + H](+) and [Z-PG + alkali metal](+) suggest that optimized cation-pi and hydrogen bonding interactions of carbonyl groups in final products are important for ND3 adduct formation.	Hydrogen	131-139	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	216-219
33405506-1	2021	Gas management during electrocatalytic water splitting is vital for improving the efficiency of clean hydrogen production.	Hydrogen	102-110	gastrin	Homo sapiens	0-3
26519933-5	2015	Molecular docking studies revealed that the PKR-inhibitor binds in the large hydrophobic cavity of the kinase domain of MARK4 through several hydrophobic and hydrogen-bonded interactions.	Hydrogen	158-166	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	44-47
26519933-5	2015	Molecular docking studies revealed that the PKR-inhibitor binds in the large hydrophobic cavity of the kinase domain of MARK4 through several hydrophobic and hydrogen-bonded interactions.	Hydrogen	158-166	microtubule affinity regulating kinase 4	Homo sapiens	120-125
33333448-5	2021	Four compounds (1b, 1f, 1g and 1h) showed high hH3R affinity (pKi > 7), compound 1h being the most potent (pKi 8.4), and compound 1f showed the best efficiency (pKi 8.2, LE 0.53, LLE 5.85).	Hydrogen	31-33	histamine receptor H3	Homo sapiens	47-51
26388205-0	2015	Microsecond X-ray Absorption Spectroscopy Identification of Co(I) Intermediates in Cobaloxime-Catalyzed Hydrogen Evolution.	Hydrogen	104-112	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	60-65
26388205-3	2015	This method was used to obtain the solution structure of the Co(I) intermediate of cobaloxime, which is a non-noble metal catalyst for solar hydrogen production from water.	Hydrogen	141-149	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	61-66
26327311-0	2015	A two-storey structured photoanode of a 3D Cu2ZnSnS4/CdS/ZnO@steel composite nanostructure for efficient photoelectrochemical hydrogen generation.	Hydrogen	126-134	CDP-diacylglycerol synthase 1	Homo sapiens	53-56
26327311-1	2015	A two-storey structured photoanode of a 3D Cu2ZnSnS4(CZTS)/CdS/ZnO@steel composite nanostructure has been fabricated by using the solution method and demonstrated highly efficient photoelectrochemical hydrogen generation due to its contraption in the structure for sufficient light absorption as well as the three step-down band alignments for efficient charge separation and transport.	Hydrogen	201-209	CDP-diacylglycerol synthase 1	Homo sapiens	59-62
33444100-1	2021	The paper presents the effect of replacing starch (at 2%, 6% and 10%) with cricket powder (CP) on the water behavior studied by the 1H NMR method, as well as the texture of gluten-free bread during 6-day storage.	Hydrogen	132-134	ceruloplasmin	Homo sapiens	91-93
26327311-4	2015	The related mechanism has been investigated, which demonstrates that the two-storey CZTS/CdS/ZnO@steel composite nanostructure would have great potential as a promising photoelectrode with high efficiency and low cost for PEC hydrogen generation.	Hydrogen	226-234	CDP-diacylglycerol synthase 1	Homo sapiens	89-92
33376139-8	2021	This active site water is a hydronium ion based on the analysis of its hydrogen bond network in the OhyA PEG400 FAD complex.	Hydrogen	71-79	AT695_RS03350	Staphylococcus aureus	100-104
26116148-4	2015	Folate anchors to FBP through a network of hydrogen bonds and hydrophobic interactions, and the binding induces a conformational change with formation of hydrophilic and stable holo-FBP.	Hydrogen	43-51	folate receptor alpha	Homo sapiens	18-21
26340532-4	2015	The histidine functionalized perylenediimide (PDI-HIS) molecule could coassemble with amyloid beta (Abeta) peptides via hydrogen bonding that leads to the enhancement in the pi-pi interactions between Abeta and PDI-HIS moieties.	Hydrogen	120-128	peptidyl arginine deiminase 1	Homo sapiens	46-49
26340532-4	2015	The histidine functionalized perylenediimide (PDI-HIS) molecule could coassemble with amyloid beta (Abeta) peptides via hydrogen bonding that leads to the enhancement in the pi-pi interactions between Abeta and PDI-HIS moieties.	Hydrogen	120-128	peptidyl arginine deiminase 1	Homo sapiens	211-214
26204819-4	2015	The increase in intracellular Zn(2+) was chelated with intracellular ZnAF-2 in the CA1 1h after local injection of ZnAF-2DA into the CA1, suggesting that intracellular Zn(2+) signaling induced during learning is blocked with intracellular ZnAF-2 when the learning was performed 1h after ZnAF-2DA injection.	Hydrogen	87-89	carbonic anhydrase 1	Rattus norvegicus	83-86
26204819-4	2015	The increase in intracellular Zn(2+) was chelated with intracellular ZnAF-2 in the CA1 1h after local injection of ZnAF-2DA into the CA1, suggesting that intracellular Zn(2+) signaling induced during learning is blocked with intracellular ZnAF-2 when the learning was performed 1h after ZnAF-2DA injection.	Hydrogen	87-89	carbonic anhydrase 1	Rattus norvegicus	133-136
26594441-2	2015	In the crystal, two O-H O hydrogen bonds between the hy-droxy groups at the C-1 and C-3 positions, and at the C-4 and C-5 positions connect homochiral mol-ecules into a column along the a axis.	Hydrogen	26-34	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	76-87
26664576-4	2015	Racemic and enantiopure bis(ethylenedithio)tetrathiafulvalene (BEDT-TTF) derivatives possessing hydroxymethyl groups as the source of hydrogen bonds were designed.	Hydrogen	134-142	ras homolog family member H	Homo sapiens	68-71
26337119-1	2015	Morphology-controlled synthesis of CdS can significantly enhance the efficiency of its photocatalytic hydrogen production.	Hydrogen	102-110	CDP-diacylglycerol synthase 1	Homo sapiens	35-38
26270392-3	2015	Highly uniform dispersion and intimate interactions between CdS and multicomponent cocatalysts, together with improved separation of photogenerated carriers due to the presence of Te nanotubes (NTs) and trace CdTe, enable CdS-based heterostructured photocatalysts to exhibit greatly enhanced efficiency and stability in the photocatalytic production of H2.	Hydrogen	353-355	CDP-diacylglycerol synthase 1	Homo sapiens	60-63
26270392-3	2015	Highly uniform dispersion and intimate interactions between CdS and multicomponent cocatalysts, together with improved separation of photogenerated carriers due to the presence of Te nanotubes (NTs) and trace CdTe, enable CdS-based heterostructured photocatalysts to exhibit greatly enhanced efficiency and stability in the photocatalytic production of H2.	Hydrogen	353-355	CDP-diacylglycerol synthase 1	Homo sapiens	222-225
26323304-4	2015	The overall fold of CEACAM7 is similar to those of CEACAM1 and CEACAM5; however, there are differences, the most notable of which is an insertion that causes the C"" strand to buckle, leading to the creation of a hydrogen bond in the dimerization interface.	Hydrogen	213-221	CEA cell adhesion molecule 7	Homo sapiens	20-27
26323304-4	2015	The overall fold of CEACAM7 is similar to those of CEACAM1 and CEACAM5; however, there are differences, the most notable of which is an insertion that causes the C"" strand to buckle, leading to the creation of a hydrogen bond in the dimerization interface.	Hydrogen	213-221	CEA cell adhesion molecule 5	Homo sapiens	63-70
26076332-8	2015	KEY RESULTS: Compound L6H21 inserted into the hydrophobic region of the MD-2 pocket, forming hydrogen bonds with Arg(90) and Tyr(102) in the MD-2 pocket.	Hydrogen	93-101	lymphocyte antigen 96	Mus musculus	72-76
26076332-8	2015	KEY RESULTS: Compound L6H21 inserted into the hydrophobic region of the MD-2 pocket, forming hydrogen bonds with Arg(90) and Tyr(102) in the MD-2 pocket.	Hydrogen	93-101	lymphocyte antigen 96	Mus musculus	141-145
26081427-8	2015	In experiment 2, the R trial showed a marked increase in plasma irisin concentration 1h after exercise (P&lt;0.05), but not in the E or R+E trials.	Hydrogen	85-87	fibronectin type III domain containing 5	Homo sapiens	64-70
26100249-4	2015	Molecular docking simulation analysis revealed that curcumin fit well in the binding pocket of Hsp90, with hydrogen bonds, hydrophobic interactions and conjugation to maintain adhesion.	Hydrogen	107-115	heat shock protein 90 alpha family class A member 1	Homo sapiens	95-100
26207519-13	2015	A gas-phase reaction between methyl formate and the cyanomethyl radical CH2CN to produce a hydrogen atom and cyanomethyl formate was mimicked using MP2/cc-pVTZ calculations.	Hydrogen	91-99	tryptase pseudogene 1	Homo sapiens	148-151
26132437-5	2015	The pentapeptide, acA5nme, where there are three intrapeptide backbone hydrogen bonds, shows a conformational free energy landscape with a much greater degree of sensitivity to the choice of solvent model, though the three rigid-body water models differ only quantitatively.	Hydrogen	71-79	small nucleolar RNA, H/ACA box 5A	Homo sapiens	18-22
26162669-3	2015	The HS-SPME parameters were optimized as follows: selection of CAR/PDMS fiber, 0.5% 2-(bromomethyl)naphthalene, 250 mg/L 15-crown-5-ether as a phase transfer catalyst, extraction and derivatization temperature of 95  C, heating time of 20 min and pH of 7.0.	Hydrogen	4-6	CXADR pseudogene 1	Homo sapiens	63-66
26203127-3	2015	We used hydrogen-deuterium exchange mass spectrometry (HX MS) to determine the ADAMTS13 binding epitope for three representative human monoclonal autoantibodies, isolated from TTP patients by phage display as tethered single-chain fragments of the variable regions (scFvs).	Hydrogen	8-16	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	79-87
26006043-8	2015	Pre-treatment of cells with 0.5 or 5mM NAC at 0.5 or 1h and its subsequent washout before MeHg addition suppressed MCP-1 and IL-6 cytokine expressions.	Hydrogen	53-55	C-C motif chemokine ligand 2	Homo sapiens	115-120
25954991-0	2015	Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion injury.	Hydrogen	0-8	poly (ADP-ribose) polymerase 1	Rattus norvegicus	105-135
25954991-2	2015	The present study was conducted to demonstrate whether hydrogen-rich saline (HRS) has a neuroprotective effect on retinal ischemia reperfusion (RIR) injury through inhibition of PARP-1 activation.	Hydrogen	55-63	poly (ADP-ribose) polymerase 1	Rattus norvegicus	178-184
26178114-1	2015	In low dimensional cesium silicate LDS-1 (monoclinic phase of CsHSi2O5), anomalous infrared absorption bands observed at 93, 155, 1210, and 1220 cm(-1) are assigned to the vibrational mode of protons, which contribute to the strong hydrogen bonding between terminal oxygen atoms of silicate chain (O-O distance = 2.45 A).	Hydrogen	232-240	transforming growth factor beta receptor 1	Homo sapiens	35-40
26050754-0	2015	Highly-efficient cocatalyst-free H2-evolution over silica-supported CdS nanoparticle photocatalysts under visible light.	Hydrogen	33-35	CDP-diacylglycerol synthase 1	Homo sapiens	68-71
26050754-1	2015	A silica-supported CdS nanoparticle photocatalyst exhibits excellent visible-light driven H2 evolution activity without the use of a cocatalyst.	Hydrogen	90-92	CDP-diacylglycerol synthase 1	Homo sapiens	19-22
26014101-2	2015	As a first example, hydrogen ions are released from a selective polymeric membrane (proton pump) and the resulting pH is assessed potentiometrically with a second membrane placed directly opposite.	Hydrogen	20-28	ATPase H+/K+ transporting non-gastric alpha2 subunit	Homo sapiens	84-95
20013135-3	2010	Based on systematic examination of hydrogen bond breaking and classical MD/molecular mechanics-generalized Born/surface area) (MM-GBSA) calculations, a CDK5 activation mechanism by p25 is suggested.	Hydrogen	35-43	cyclin dependent kinase 5	Homo sapiens	152-156
21579372-2	2010	The crystal structure is stabilized by inter-molecular N-H S hydrogen bonds, resulting in the formation of eight-membered rings lying about inversion centers and representing R(2) (2)(8) and R(4) (2)(8) motifs.	Hydrogen	61-69	ribonucleotide reductase regulatory subunit M2	Homo sapiens	175-179
19885870-2	2010	The parameters needed in the scheme are derived from fitting to the hydrogen bonding energies of MP2/6-31+G** with basis set superposition error (BSSE) correction of the hydrogen bond chains of formamides containing from two to eight monomeric units.	Hydrogen	68-76	tryptase pseudogene 1	Homo sapiens	97-100
20689681-10	2010	The phosphate oxygens OP1 or OP2 are used as hydrogen bond acceptors in 12% of all nucleotides, and the ribose ring oxygen O4" and phosphodiester oxygens O3" and O5" are used in 4%, 4%, and 1% of all nucleotides, respectively.	Hydrogen	45-53	bone morphogenetic protein 8b	Homo sapiens	29-32
20177057-7	2010	To directly address the mechanism of nucleotide exchange, we have compared the hydrogen-exchange characteristics of a yeast Hsp70 NBD (Ssa1) in complex with either Sse1 or Lhs1.	Hydrogen	79-87	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	135-139
21579100-3	2010	In the crystal, mol-ecules are linked by N-H O hydrogen bonds, generating C(4) chains.	Hydrogen	47-55	complement C4A (Rodgers blood group)	Homo sapiens	74-78
20178830-3	2010	However, NT-3 (1h, 100ng/ml) strongly potentiates evoked ACh release from the weak (70%) and the strong (50%) axonal inputs on dually innervated postnatal endplates (P6) but not in the most developed postnatal singly innervated synapses at P6.	Hydrogen	15-17	neurotrophin 3	Mus musculus	9-13
21580785-2	2010	In the crystal structure, mol-ecules are connected by N-H O hydrogen bonds, forming C(4) chains running along the c axis.	Hydrogen	60-68	complement C4A (Rodgers blood group)	Homo sapiens	84-88
21580790-3	2010	This results in two-dimensional arrays in the ab plane, mediated by the hydrogen bonding, sandwiched by tert-butyl groups.	Hydrogen	72-80	telomerase reverse transcriptase	Homo sapiens	104-108
20370122-4	2010	The experimental results are complemented with ab initio electronic structure calculations at the MP2 and CCSD(T) levels of theory that identified several isomers on the ground state potential energy function arising from the ability of CN(-) to form hydrogen bonds with water via both the C and N ends.	Hydrogen	251-259	tryptase pseudogene 1	Homo sapiens	98-101
20146531-9	2010	Formation of a complex with intact Hsp70 and Hsp90 or their respective C-terminal octapeptides induced folding of the TPR domain to a defined, highly stabilized structure with protected amide hydrogens.	Hydrogen	192-201	heat shock protein 90 alpha family class A member 1	Homo sapiens	45-50
20306218-2	2010	The comparison between the structures of the promastoparans both before and after docking were examined along with the hydrogen bonding interaction pattern between the dipetidyl peptidase IV (DPPIV) and promastoparans to reveal how the endpoint of this stepwise cleavage is recognized among these promastoparans with highly resemble amino acid sequences.	Hydrogen	119-127	dipeptidyl peptidase 4	Homo sapiens	168-190
20306218-2	2010	The comparison between the structures of the promastoparans both before and after docking were examined along with the hydrogen bonding interaction pattern between the dipetidyl peptidase IV (DPPIV) and promastoparans to reveal how the endpoint of this stepwise cleavage is recognized among these promastoparans with highly resemble amino acid sequences.	Hydrogen	119-127	dipeptidyl peptidase 4	Homo sapiens	192-197
19609577-4	2010	Alterations in the NH-Sgamma hydrogen-bonding network may provide a rationale for the differences in dynamic properties encountered in the beta-domains of MT-1, -2, and -3 isoforms, believed to be essential for their different biological function.	Hydrogen	29-37	metallothionein 1I, pseudogene	Homo sapiens	155-171
19330460-7	2010	Hydrophobic and hydrogen-bond interactions lead to identification of active binding sites of EGFR protein in the docked complex.	Hydrogen	16-24	epidermal growth factor	Homo sapiens	93-97
20023383-2	2010	The miR-8 family of miRNAs plays a key role in this process by precisely regulating the activity of NHERF1, a regulator of sodium hydrogen exchange that also serves as an adaptor protein linked to the actin cytoskeleton.	Hydrogen	130-138	SLC9A3 regulator 1a	Danio rerio	100-106
19931544-10	2010	The Bax protein level increased 1h after GI-R and was markedly reduced by intravenous administration of 17beta-estradiol.	Hydrogen	32-34	BCL2 associated X, apoptosis regulator	Rattus norvegicus	4-7
20410615-4	2010	Docking studies show that the imine moiety is located in hydrophobic pocket, bringing the propargyl group close to FAD which indicates that the different inhibitory potency toward MAO-A may be ascribable to both the distance between alkynyl group and N5 of FAD, and hydrogen bonding interactions between inhibitors and enzymes.	Hydrogen	266-274	monoamine oxidase A	Homo sapiens	180-185
19879672-4	2010	Docking study showed that flavonoids bind to the BChE active site by forming multiple hydrogen bonds and pi-pi interactions.	Hydrogen	86-94	butyrylcholinesterase	Homo sapiens	49-53
19928840-9	2009	A thermodynamic analysis of H(2) evolution pathways sheds new light on the barriers and driving forces of the elementary reaction steps involved in proton reduction by Co(I)-diglyoximes.	Hydrogen	28-32	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	168-173
20167001-12	2009	Pharmacophore models have revealed that hydrogen bonding, ion-pair interactions, and probably hydrophobic interactions play a major role in determining the substrate specificity and inhibitor selectivity of CYP2C9.	Hydrogen	40-48	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	207-213
25908484-0	2015	Intramolecular Hydrogen Bonds Enhance Disparity in Reactivity between Isomers of Photoswitchable Sorbents and CO2 : A Computational Study.	Hydrogen	15-23	complement C2	Homo sapiens	110-113
25908484-4	2015	The first-principles calculations demonstrate that intramolecular hydrogen bonds are crucial for enlarging the difference of CO2 binding strengths to the cis and trans isomers.	Hydrogen	66-74	complement C2	Homo sapiens	125-128
19915056-4	2009	We found that in both cortical and medullary TEC lines, LC3 was colocalized with the H2-DM-positive lysosomal compartments, in which MHC class II plus class II-associated invariant chain peptides complexes are formed.	Hydrogen	85-87	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	56-59
33415981-5	2021	Hydrogen/deuterium exchange mass spectrometry (HDX-MS) in the higher-order structure characterization of NKG2A in complex with CD94 provides novel insights into the conformational dynamics of NKG2A/CD94 heterodimer.	Hydrogen	0-8	killer cell lectin like receptor C1	Homo sapiens	105-110
19831375-9	2009	The binding energies for both the sigma-type and pi-type hydrogen-bonded M.L complexes (M = indole and 3-methylindole; L = H(2)O and H(2)S) were calculated by extrapolating MP2 interaction energies to the complete basis set limit.	Hydrogen	57-65	tryptase pseudogene 1	Homo sapiens	173-176
19744646-7	2009	These extended conformers were stabilized by a quite persistent intramolecular hydrogen bond between the hydroxyl groups of carbon C-2 and C-4.	Hydrogen	79-87	complement C2	Homo sapiens	131-134
25982331-1	2015	Combination of the Suzuki cross-coupling and nucleophilic aromatic substitution of hydrogen (SN(H)) reactions proved to be a convenient method for the synthesis of C(4) and/or C(5) mono(thienyl) and di(thienyl) substituted pyrimidines from commercially available 5-bromopyrimidine.	Hydrogen	83-91	complement component 4B (Chido blood group)	Mus musculus	164-168
25940738-2	2015	Wheresas oxygen-atom transfer prevails in the reaction of the oxide complex [OTiH](+) with CO2 , generating [OTi(OH)](+) under the elimination of CO, insertion of CO2 into the metal-hydrogen bond of the cyclopentadienyl complex, [Cp2 TiH](+) , gives rise to the formate complex [Cp2 Ti(O2 CH)](+) .	Hydrogen	182-190	ceruloplasmin	Homo sapiens	230-233
25940738-2	2015	Wheresas oxygen-atom transfer prevails in the reaction of the oxide complex [OTiH](+) with CO2 , generating [OTi(OH)](+) under the elimination of CO, insertion of CO2 into the metal-hydrogen bond of the cyclopentadienyl complex, [Cp2 TiH](+) , gives rise to the formate complex [Cp2 Ti(O2 CH)](+) .	Hydrogen	182-190	ceruloplasmin	Homo sapiens	279-282
24961937-6	2015	In vivo studies revealed that acute co-incubation of N-acetylcysteine or hydrogen-rich saline with VEGF effectively suppressed VEGF-induced angiogenesis and migration of HUVEC accompanied by decreasing of oxidative stress and inflammatory cytokines.	Hydrogen	73-81	vascular endothelial growth factor A	Rattus norvegicus	99-103
24961937-6	2015	In vivo studies revealed that acute co-incubation of N-acetylcysteine or hydrogen-rich saline with VEGF effectively suppressed VEGF-induced angiogenesis and migration of HUVEC accompanied by decreasing of oxidative stress and inflammatory cytokines.	Hydrogen	73-81	vascular endothelial growth factor A	Rattus norvegicus	127-131
19744646-7	2009	These extended conformers were stabilized by a quite persistent intramolecular hydrogen bond between the hydroxyl groups of carbon C-2 and C-4.	Hydrogen	79-87	complement C4A (Rodgers blood group)	Homo sapiens	139-142
19744646-8	2009	The conformational populations were found to be in good agreement with the limited available NMR data except for the C-2-C-3 torsion (spanned by the O-2-O-4 hydrogen bond), where the NMR data support a more bent structure.	Hydrogen	157-165	complement C2	Homo sapiens	117-120
33415981-5	2021	Hydrogen/deuterium exchange mass spectrometry (HDX-MS) in the higher-order structure characterization of NKG2A in complex with CD94 provides novel insights into the conformational dynamics of NKG2A/CD94 heterodimer.	Hydrogen	0-8	killer cell lectin like receptor C1	Homo sapiens	192-197
33053321-4	2021	Using a combination of X-ray crystallography, hydrogen-deuterium exchange coupled to mass spectrometry and complementary biochemical and biophysical methods, we reveal extensive structural defects in three disease-causing SRP54 variants resulting in critical protein destabilization.	Hydrogen	46-54	signal recognition particle 54	Homo sapiens	222-227
19809740-8	2009	The 1H NMR spectra of 10 showed broad signals for the CH2N and NMe2 groups, which represent dynamical fluctuations of the molecules in solution state.	Hydrogen	4-6	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	63-67
19774274-4	2009	The largest MP2/TZV(2df,2pd) cooperativity of -9 kcal mol(-1) is obtained for a hydrogen-bonded guanine trimer.	Hydrogen	80-88	tryptase pseudogene 1	Homo sapiens	12-15
25721096-5	2015	The photoinduced electron transfer from the excited dye that labels the oligonucleotide probe to the CoP semiconductor led to efficient fluorescence quenching, and largely enhanced the photocatalytic evolution of hydrogen from water under visible light.	Hydrogen	213-221	caspase recruitment domain family member 16	Homo sapiens	101-104
33248643-1	2021	A novel heteronanostructure of nanodiamonds (NDs) and hydrogen-substituted graphdiyne (HsGDY) (denoted as HsGDY@NDs) was prepared for the impedimetric aptasensing of biomarkers such as myoglobin (Myo) and cardiac troponin I (cTnI).	Hydrogen	54-62	myoglobin	Homo sapiens	185-194
25759281-3	2015	The hydrogen evolution rate of CdS-30 mol %-ZnWO4 reaches 31.46 mmol h(-1)  g(-1) under visible light, which is approximately 8 and 755 times higher than that of pure CdS and ZnWO4 under similar conditions, respectively.	Hydrogen	4-12	CDP-diacylglycerol synthase 1	Homo sapiens	31-34
25759281-3	2015	The hydrogen evolution rate of CdS-30 mol %-ZnWO4 reaches 31.46 mmol h(-1)  g(-1) under visible light, which is approximately 8 and 755 times higher than that of pure CdS and ZnWO4 under similar conditions, respectively.	Hydrogen	4-12	CDP-diacylglycerol synthase 1	Homo sapiens	167-170
19515407-4	2009	Plasma P(4) levels were increased from pretreatment levels by 30% at 1h (P=0.05) and 81% at 48h (P=0.02) after hCG treatment.	Hydrogen	69-71	solute carrier family 10 member 4	Homo sapiens	7-11
33248643-1	2021	A novel heteronanostructure of nanodiamonds (NDs) and hydrogen-substituted graphdiyne (HsGDY) (denoted as HsGDY@NDs) was prepared for the impedimetric aptasensing of biomarkers such as myoglobin (Myo) and cardiac troponin I (cTnI).	Hydrogen	54-62	myoglobin	Homo sapiens	196-199
19413997-12	2009	Surprisingly, Epo rapidly (&lt;1h) induces mobilization of activated erythroid precursors into the blood, thus allowing drug-response relationships to guide discovery.	Hydrogen	31-33	erythropoietin	Mus musculus	14-17
33038651-3	2021	When a systematic heat shock was applied, a maximal hydrogen yield of 17.2 +- 3.8 mLH2/gVS was attained.	Hydrogen	52-60	LIM homeobox protein 2	Mus musculus	82-86
19483477-3	2009	Additionally, VEGF-induced vessel sprouting of rat aortic ring was also inhibited by HS.	Hydrogen	85-87	vascular endothelial growth factor A	Rattus norvegicus	14-18
25853415-6	2015	The hinge loop of domain swapping for cyt c family proteins corresponded to the unstable region specified by hydrogen exchange NMR measurements for the monomer, although the swapping region differed among proteins.	Hydrogen	109-117	cytochrome c, somatic	Equus caballus	38-43
33038651-4	2021	The hydrogen productivity was improved by 331% reaching a stable value of 1.51 +- 0.29 mLH2/gVS/h, after 8 cycles of effluent recycling.	Hydrogen	4-12	LIM homeobox protein 2	Mus musculus	87-91
32962610-0	2021	Hydrogen Gas as an Exotic Performance-Enhancing Agent: Challenges and Opportunities.	Hydrogen	0-8	gastrin	Homo sapiens	9-12
25711416-0	2015	Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics.	Hydrogen	0-8	interleukin 23 subunit alpha	Homo sapiens	57-62
25711416-4	2015	Hydrogen/deuterium exchange mass spectrometry and computational methods were applied to probe the binding interactions between IL-23 and Adnectin 2 and to determine the correlation between the two orthogonal methods.	Hydrogen	0-8	interleukin 23 subunit alpha	Homo sapiens	127-132
19675666-7	2009	Cys32(Trx) is activated for its nucleophilic attack by hydrogen bonds, and Cys32(Trx) is found to be more reactive than Cys82(ArsC).	Hydrogen	55-63	thioredoxin	Homo sapiens	6-9
20021881-6	2009	RESULTS: Computer construction and analysis of protein models of the mutant FBN1 gene revealed that the mutant Arg545Cys FBN1 protein had various changes on protein"s secondary structure with an absence of a helix, decreased hydrogen bond distance, different protein surface solvent-accessibility and decreased negative electrostatic potential.	Hydrogen	225-233	fibrillin 1	Homo sapiens	76-80
32962610-1	2021	BACKGROUND: Hydrogen gas (H2 ) has entered the world of experimental therapeutics approximately four and a half decades ago.	Hydrogen	12-20	gastrin	Homo sapiens	21-24
20021881-6	2009	RESULTS: Computer construction and analysis of protein models of the mutant FBN1 gene revealed that the mutant Arg545Cys FBN1 protein had various changes on protein"s secondary structure with an absence of a helix, decreased hydrogen bond distance, different protein surface solvent-accessibility and decreased negative electrostatic potential.	Hydrogen	225-233	fibrillin 1	Homo sapiens	121-125
20021881-7	2009	The mutant Arg1530Cys FBN1 showed lost of hydrogen bonds, different protein surface solvent-accessibility and increased negative electrostatic potential.	Hydrogen	42-50	fibrillin 1	Homo sapiens	22-26
25213553-9	2015	Taken together, CERS2 can significantly inhibit breast cancer cell invasion and is associated with the decrease of the V-ATPase activity and extracellular hydrogen ion concentration, and in turn the activation of secreted MMP-2/MMP-9 and degradation of extracellular matrix (ECM), which ultimately suppressed tumor"s invasion.	Hydrogen	155-163	ceramide synthase 2	Homo sapiens	16-21
25619729-0	2015	Misfit-layered Bi1.85 Sr2 Co1.85 O7.7-delta for the hydrogen evolution reaction: beyond van der Waals heterostructures.	Hydrogen	52-60	transmembrane BAX inhibitor motif containing 6	Homo sapiens	15-18
25619729-5	2015	The hydrogen-evolution performance of misfit-layered Bi1.85 Sr2 Co1.85 O7.7-delta , which has an overpotential of 589 mV and a Tafel slope of 51 mV per decade, demonstrates the promising potential of misfit-layered chalcogenides as electrocatalysts instead of classical carbon.	Hydrogen	4-12	transmembrane BAX inhibitor motif containing 6	Homo sapiens	53-56
32962610-9	2021	Also, appropriate regulation of hydrogen utilization in sport as an exotic medical gas may require distinctive legislative actions of relevant regulatory agencies in the future.	Hydrogen	32-40	gastrin	Homo sapiens	83-86
19569659-1	2009	This paper presents an application of the reaction class transition state theory (RC-TST) to predict thermal rate constants for hydrogen abstraction reactions of the type C(2)H(3) + alkane --&gt; C(2)H(4) + alkyl radical.	Hydrogen	128-136	thiosulfate sulfurtransferase	Homo sapiens	85-88
33349213-0	2021	Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.	Hydrogen	0-8	gastrin	Homo sapiens	9-12
19405506-7	2009	Interactions of CD27 with 5"-AATT include bifurcated hydrogen bonds, providing a basis for selectivity of this site, and favorable van der Waals interactions in a slightly widened minor groove.	Hydrogen	53-61	CD27 molecule	Homo sapiens	16-20
33349213-1	2021	BACKGROUND: Mounting evidence indicates that hydrogen gas (H2 ) is a versatile therapeutic agent, even at very low, non-combustible concentrations.	Hydrogen	45-53	gastrin	Homo sapiens	54-57
32926543-3	2020	Over the past century, ammonia production has been dominated by the Haber-Bosch process, in which a mixture of nitrogen and hydrogen gas is converted to ammonia at high temperatures and pressures.	Hydrogen	124-132	gastrin	Homo sapiens	133-136
19397896-3	2009	Buried within the peptide"s flexible region, W(258) may hydrogen-bond with L(255) to help stabilize the Pro-kinked hCB2 TMH6 structure and position C(257) advantageously for interaction with agonist ligands.	Hydrogen	56-64	cannabinoid receptor 2	Homo sapiens	115-119
25753737-7	2015	Crystal structure modeling on the protein eyes shut homolog encoded by the EYS gene revealed abnormal hydrogen bonds generated by p.C2139Y and p.F2954S, which would likely affect the solubility and cause significant structural changes of the two mutated proteins.	Hydrogen	102-110	eyes shut homolog	Homo sapiens	75-78
25203215-0	2015	A TDDFT/EFP1 study on hydrogen bonding dynamics of coumarin 151 in water.	Hydrogen	22-30	thioredoxin domain containing 11	Homo sapiens	8-12
32926543-4	2020	Haber-Bosch processes with natural gas as source of hydrogen are responsible for a significant share of the global CO2 emissions.	Hydrogen	52-60	gastrin	Homo sapiens	35-38
33186020-7	2020	Interaction analyses reveal that hydrophobic and hydrogen-bonding interactions between EGCG and alpha-syn fibrils play important roles in the destabilization of the fibril.	Hydrogen	49-57	synuclein alpha	Homo sapiens	96-105
25586722-8	2015	The tethering of polymer side chains within PAF-1 pores is responsible for maintaining H2 transport pathways, whilst the larger N2 pathways gradually collapse.	Hydrogen	87-89	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	44-49
19432560-4	2009	We used 15N-1H-HSQC (heteronuclear single quantum coherence) NMR experiments with 15N-enriched gal-1 to identify the GRG-binding region on gal-1 and found that this region covers a large surface area on gal-1 that includes the quintessential lactose-binding site and runs from that site through a broad valley or cleft towards the dimer interface.	Hydrogen	12-14	galectin 1	Homo sapiens	139-144
19432560-4	2009	We used 15N-1H-HSQC (heteronuclear single quantum coherence) NMR experiments with 15N-enriched gal-1 to identify the GRG-binding region on gal-1 and found that this region covers a large surface area on gal-1 that includes the quintessential lactose-binding site and runs from that site through a broad valley or cleft towards the dimer interface.	Hydrogen	12-14	galectin 1	Homo sapiens	139-144
19636939-0	2009	Backbone and sidechain 1H, 15N, and 13C assignments of the human eIF5A.	Hydrogen	23-25	eukaryotic translation initiation factor 5A	Homo sapiens	65-70
19636941-0	2009	1H, 13C and 15N resonance assignments for Binder of Arl2, BART.	Hydrogen	0-2	ADP ribosylation factor like GTPase 2	Homo sapiens	52-56
19636941-0	2009	1H, 13C and 15N resonance assignments for Binder of Arl2, BART.	Hydrogen	0-2	ADP ribosylation factor like GTPase 2 binding protein	Homo sapiens	58-62
33020180-5	2020	The N196K residue appears to stabilize the open conformation of U2AF2 with an inter-RRM hydrogen bond, in agreement with an increased apparent RNA binding affinity of the N196K-substituted protein.	Hydrogen	88-96	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	64-69
19636948-0	2009	1H, 15N, 13C resonance assignments of the reduced and active form of human Protein Tyrosine Phosphatase, PRL-1.	Hydrogen	0-2	protein tyrosine phosphatase 4A1	Homo sapiens	105-110
25629649-0	2015	A database of dispersion-induction DI, electrostatic ES, and hydrogen bonding alpha1 and beta1 solvent parameters and some applications to the multiparameter correlation analysis of solvent effects.	Hydrogen	61-69	adrenoceptor alpha 1D	Homo sapiens	78-94
19368400-4	2009	Our analysis of several features of MP2/aug-cc-pVDZ-optimized stable clusters with different number and arrangement of water molecules shows that two different kinds of halogen-water coordination patterns are involved in the stability and properties found for these systems: halogen bonds (X-X...O) and halogen-hydrogen interactions, (X-X...H-O-H).	Hydrogen	311-319	tryptase pseudogene 1	Homo sapiens	36-39
32687900-3	2020	The maximum solubility of lignin in the sample DES-2 (ChCl:Gly:PEG-400 = 1:2:2) could up to 66.70 g/100 g solvent at 60  C due to the hydrogen bonds are the main driving force, which was confirmed by the largest hydrogen bond basicity parameter beta value and disappearance of crystalline peak.	Hydrogen	134-142	delta 4-desaturase, sphingolipid 2	Homo sapiens	47-52
19662724-3	2009	Sodium 2,4,6-trimethylbenzoyl-phenylphosphine oxide (TMPO-Na = APO-Na) was synthesized in 67.1% yield and identified by 1H NMR.	Hydrogen	120-122	thymopoietin	Homo sapiens	53-57
25604038-4	2015	It exists in PdHx up to the hydrogen content x corresponding to the complete filling of the 4d Pd-derived energy bands because of the presence of two kinds of carriers at the Fermi surface.	Hydrogen	28-36	pyruvate dehydrogenase complex component X	Homo sapiens	13-17
25604038-6	2015	Additionally, we investigate the spatial distribution inside the crystal of a potential caused by a time-dependent external perturbation and observe drastic modifications in the screening properties in the PdHx systems with energy and with hydrogen concentration.	Hydrogen	240-248	pyruvate dehydrogenase complex component X	Homo sapiens	206-210
32687900-3	2020	The maximum solubility of lignin in the sample DES-2 (ChCl:Gly:PEG-400 = 1:2:2) could up to 66.70 g/100 g solvent at 60  C due to the hydrogen bonds are the main driving force, which was confirmed by the largest hydrogen bond basicity parameter beta value and disappearance of crystalline peak.	Hydrogen	212-220	delta 4-desaturase, sphingolipid 2	Homo sapiens	47-52
20069755-7	2009	The biophysical measurements involving thermal and chemical denaturation and renaturation kinetics clearly showed that two of the mutant Fab molecules possessed significantly improved characteristics as compared to the wild type B6 Fab.Structural modelling revealed that B6 Fab mutants had increased hydrogen bonding resulting in increased stability.	Hydrogen	300-308	FA complementation group B	Homo sapiens	137-140
20069755-7	2009	The biophysical measurements involving thermal and chemical denaturation and renaturation kinetics clearly showed that two of the mutant Fab molecules possessed significantly improved characteristics as compared to the wild type B6 Fab.Structural modelling revealed that B6 Fab mutants had increased hydrogen bonding resulting in increased stability.	Hydrogen	300-308	FA complementation group B	Homo sapiens	232-235
20069755-7	2009	The biophysical measurements involving thermal and chemical denaturation and renaturation kinetics clearly showed that two of the mutant Fab molecules possessed significantly improved characteristics as compared to the wild type B6 Fab.Structural modelling revealed that B6 Fab mutants had increased hydrogen bonding resulting in increased stability.	Hydrogen	300-308	FA complementation group B	Homo sapiens	232-235
25575657-4	2015	We show the SAR suggesting the importance of having a hydrogen bond donor in this pocket for inhibiting PIM2; however, this interaction is not important for inhibiting PIM1 or PIM3.	Hydrogen	54-62	Pim-2 proto-oncogene, serine/threonine kinase	Homo sapiens	104-108
33003963-5	2020	Molecular docking demonstrated that the high active inhibitors interacted with alpha-glucosidase by four types of interactions, including hydrogen bonds, pi-pi stacking interactions, hydrophobic interactions, and electrostatic interaction.	Hydrogen	138-146	sucrase-isomaltase	Homo sapiens	79-96
18728994-4	2009	The results showed that the inhibition was non-competitive, stabilized mainly by hydrogen bonds and hydrophobic interactions between the inhibitor and butyrylcholinesterase.	Hydrogen	81-89	butyrylcholinesterase	Homo sapiens	151-172
33335690-5	2020	Ser34 is the most important residue in the groove of Rab5, as it forms most hydrogen-bond interactions with GDP/GTP or NAP, and in silico mutation of Ser34 decreased the stabilization of Rab5.	Hydrogen	76-84	RAB5A, member RAS oncogene family	Homo sapiens	53-57
19065002-3	2009	Using in vivo magnetic resonance spectroscopy (MRS), we show that alterations in the integral ratios of the bis-allyl to vinyl hydrogen protons in unsaturated lipid fatty acyl groups correlate with the development of neoplastic formations in vivo in a TGFalpha/c-myc mouse hepatocellular carcinoma (HCC) model.	Hydrogen	127-135	transforming growth factor alpha	Mus musculus	252-260
25306392-10	2015	In silico analysis demonstrated that SMO(G497W) undergoes a conformational rearrangement resulting in a partial obstruction of the protein drug entry site, whereas the SMO D473Y mutation induces a direct effect on the binding site geometry leading to a total disruption of a stabilizing hydrogen bond network.	Hydrogen	287-295	smoothened, frizzled class receptor	Homo sapiens	37-40
25306392-10	2015	In silico analysis demonstrated that SMO(G497W) undergoes a conformational rearrangement resulting in a partial obstruction of the protein drug entry site, whereas the SMO D473Y mutation induces a direct effect on the binding site geometry leading to a total disruption of a stabilizing hydrogen bond network.	Hydrogen	287-295	smoothened, frizzled class receptor	Homo sapiens	168-171
19274289-2	2009	They have been fully characterized by IR spectroscopy, FAB-MS(+), elemental and single-crystal X-ray diffraction analyses, the latter also revealing intensive intermolecular hydrogen bonding in , resulting in the extension of the structural motifs and generation of tetrameric aggregates (in ) and 1D (in ) or 2D (in ) supramolecular networks.	Hydrogen	174-182	FA complementation group B	Homo sapiens	55-58
33335690-5	2020	Ser34 is the most important residue in the groove of Rab5, as it forms most hydrogen-bond interactions with GDP/GTP or NAP, and in silico mutation of Ser34 decreased the stabilization of Rab5.	Hydrogen	76-84	RAB5A, member RAS oncogene family	Homo sapiens	187-191
25461326-4	2015	A comparative study on a series of Glc-PSO derivatives suggests that hydrogen bond acceptor functionalities, e.g. fluoro or methyloxycarbonyl, significantly stabilize the Glc-PSO:GCase complex.	Hydrogen	69-77	glucosylceramidase beta	Homo sapiens	179-184
32022561-2	2020	The thermally in-duced rearrangement of Mes*-P=C=C(H)R" (R" = tBu, Ad) afforded by C-H activation, isobutene elimination, C-C and P-H bond formation bicyclic 1-benzo-dihydrophosphetes (2) with PC3 heterocycles.	Hydrogen	83-86	chromobox 8	Homo sapiens	193-196
25379648-8	2015	In oxidized NQO2, TBBz and DMAT are deeply buried in the active site and make direct hydrogen and halogen bonds to the enzyme.	Hydrogen	85-93	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	12-16
25379648-9	2015	In reduced NQO2, DMAT occupies a more peripheral region and hydrogen and halogen bonds with the enzyme are mediated through three water molecules.	Hydrogen	60-68	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	11-15
19253977-2	2009	Density functional theory and second-order Moller-Plesset perturbation theory (MP2) are used to calculate the interaction energies between H(2) and individual structural elements of the MOF-5 framework.	Hydrogen	139-143	tryptase pseudogene 1	Homo sapiens	79-82
32022561-2	2020	The thermally in-duced rearrangement of Mes*-P=C=C(H)R" (R" = tBu, Ad) afforded by C-H activation, isobutene elimination, C-C and P-H bond formation bicyclic 1-benzo-dihydrophosphetes (2) with PC3 heterocycles.	Hydrogen	130-133	chromobox 8	Homo sapiens	193-196
19281145-4	2009	Evidence is also presented for the SmH and EuH diatomic molecules and the tetrahydride anions in solid hydrogen.	Hydrogen	103-111	coiled-coil domain containing 103	Homo sapiens	35-38
32022561-7	2020	Irradiation of Trip-P=C=C(H)tBu led by the insertion of the central C atom of the P=C=C group into the alpha-C-H bond of an iPr substituent and by C-C and P-C bond formation to a new isomer of phosphaallenes, 10, which features a strained PC2 heterocycle.	Hydrogen	103-112	chromobox 4	Homo sapiens	239-242
26336997-9	2015	Additional hydrogen bonding interaction of 2"-fluorine of FMCA with R41 residue of polymerase promotes a positive binding in wild-type as well as in ADVr, ETVr and TNFr with respect to that of entecavir.	Hydrogen	11-19	TNF receptor superfamily member 1A	Homo sapiens	164-168
33210560-2	2022	The structures of products (CP 2-11) were confirmed using elemental analysis, FT-IR, MS spectral analysis as well as 31P, 1H and 13C-APT NMR techniques and their thermal properties determined by TGA and DSC techniques.	Hydrogen	122-124	ceruloplasmin	Homo sapiens	28-35
25464279-3	2015	However, an obvious peak under 100gCl/kg of PSSA appeared for Cu, owing to the presence of carbon and hydrogen in PVC.	Hydrogen	102-110	phosphatidylserine synthase 1	Homo sapiens	44-48
19013013-7	2009	Investigating the effect of SUL at the transcriptional level revealed that SUL increases the Cyp1a1 mRNA as early as 1h.	Hydrogen	117-119	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	93-99
33212941-0	2020	Non-Invasive Prediction of IDH Mutation in Patients with Glioma WHO II/III/IV Based on F-18-FET PET-Guided In Vivo 1H-Magnetic Resonance Spectroscopy and Machine Learning.	Hydrogen	115-117	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	27-30
19124468-5	2009	To address this question, we designed a series of substitutions at a proximal glutamic acid residue (Glu18) in human DJ-1 that alter the oxidative propensity of Cys106 through changes in hydrogen bonding.	Hydrogen	187-195	Parkinsonism associated deglycase	Homo sapiens	117-121
25527923-4	2014	After examination of both accuracy and performance for 394 model chemistries, SCS(MI)-MP2/cc-pVQZ can be recommended for general use, having good accuracy at low cost and no ill-effects such as imbalance between hydrogen-bonding and dispersion-dominated systems or non-parallelity across dissociation curves.	Hydrogen	212-220	tryptase pseudogene 1	Homo sapiens	86-89
33212941-5	2020	Therefore, we explored the use of machine learning for the non-invasive, inexpensive and fast diagnosis of IDH status in standard 1H-magnetic resonance spectroscopy (1H-MRS).	Hydrogen	130-132	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	107-110
19243205-3	2009	Both MP2 and SCS-MP2 geometry optimizations yield a T-shaped structure with a N--H...pi hydrogen bond to the benzene ring and the C=O group above, but far from the C--H bonds of benzene.	Hydrogen	88-96	tryptase pseudogene 1	Homo sapiens	5-8
33212941-5	2020	Therefore, we explored the use of machine learning for the non-invasive, inexpensive and fast diagnosis of IDH status in standard 1H-magnetic resonance spectroscopy (1H-MRS).	Hydrogen	166-168	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	107-110
19243205-3	2009	Both MP2 and SCS-MP2 geometry optimizations yield a T-shaped structure with a N--H...pi hydrogen bond to the benzene ring and the C=O group above, but far from the C--H bonds of benzene.	Hydrogen	88-96	tryptase pseudogene 1	Homo sapiens	17-20
33184209-0	2020	Hydrogen escape from Mars is driven by seasonal and dust storm transport of water.	Hydrogen	0-8	methionyl-tRNA synthetase 1	Homo sapiens	21-25
19223594-2	2009	This is the case when a rhodium nanosized crystal--conditioned as a field emitter tip--is exposed to hydrogen and oxygen.	Hydrogen	101-109	TOR signaling pathway regulator	Homo sapiens	82-85
25456083-7	2014	The corresponding dramatic decrease of cellular Sph (80-97% Control/1h) by DMG-B13 prodrugs was mainly from the inhibition of the lysosomal ACDase.	Hydrogen	68-70	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	79-82
32768851-5	2020	Accordingly, the maximum photocatalytic hydrogen evolution, under UV-vis light, for the same sample corresponded to 17 and 21 times the estimated for pristine ZnO NPy and AIS QDs, respectively.	Hydrogen	40-48	neuropeptide Y	Homo sapiens	163-166
26753100-4	2014	The tetramethylguanidine salt (P21/c) exhibits layers of anions hydrogen-bonded to the cations.	Hydrogen	64-72	H3 histone pseudogene 16	Homo sapiens	31-36
19192478-0	2009	Conformational changes in p47(phox) upon activation highlighted by mass spectrometry coupled to hydrogen/deuterium exchange and limited proteolysis.	Hydrogen	96-104	pleckstrin	Homo sapiens	26-29
33086047-1	2020	Amide hydrogen-deuterium exchange mass spectrometry is powerful for describing combinatorial coupling effects of a cooperative ligand pair binding at noncontiguous sites: adenosine at the ATP-pocket and a docking peptide (PIFtide) at the PIF-pocket, on a model protein kinase PDK1.	Hydrogen	6-14	PIF1 5'-to-3' DNA helicase	Homo sapiens	222-225
18955135-4	2009	The variation of affinity towards Pgp was investigated by VolSurf descriptors of Molecular Interaction Fields (MIFs) related to hydrophobic interaction forces, polarizability, and hydrogen-bonding capacity.	Hydrogen	180-188	phosphoglycolate phosphatase	Homo sapiens	34-37
19207420-0	2009	Identification of allosteric PIF-pocket ligands for PDK1 using NMR-based fragment screening and 1H-15N TROSY experiments.	Hydrogen	96-98	PIF1 5'-to-3' DNA helicase	Homo sapiens	29-32
26584372-1	2014	A new one-parameter correction scheme to second-order Moller-Plesset many-body perturbation theory (MP2) has been proposed to correctly evaluate intermolecular interaction energies of large pi-pi dispersion interaction systems as well as hydrogen-bonded and sigma-sigma dispersion interaction ones.	Hydrogen	238-246	tryptase pseudogene 1	Homo sapiens	100-103
25490117-5	2014	RESULTS: Admission hs-TnT levels were higher than the 99-percentile of the general population (14 ng/L) in all patients (range 18 to 17,837 ng/L).	Hydrogen	19-21	troponin T1, slow skeletal type	Homo sapiens	22-25
32234461-7	2020	Furthermore, H2 positively modulated beta-catenin in H2O2-treated melanocytes, and the beta-catenin pathway was implicated in H2-induced Nrf2 activation.	Hydrogen	13-15	catenin beta 1	Homo sapiens	37-49
32234461-7	2020	Furthermore, H2 positively modulated beta-catenin in H2O2-treated melanocytes, and the beta-catenin pathway was implicated in H2-induced Nrf2 activation.	Hydrogen	53-55	catenin beta 1	Homo sapiens	37-49
25248746-5	2014	X-ray crystal structures of 408-acetylated SAHH and dually acetylated SAHH have been determined and reveal perturbations in the C-terminal hydrogen bonding patterns, a region of the protein important for NAD(+) binding.	Hydrogen	139-147	adenosylhomocysteinase	Homo sapiens	43-47
32234461-8	2020	Collectively, our results indicate that H2 could be a promising therapeutic agent for vitiligo treatment via attenuating oxidative damage, and its beneficial effect in human melanocytes might involve Wnt/beta-catenin-mediated activation of Nrf2 signaling.	Hydrogen	40-42	catenin beta 1	Homo sapiens	204-216
25248746-5	2014	X-ray crystal structures of 408-acetylated SAHH and dually acetylated SAHH have been determined and reveal perturbations in the C-terminal hydrogen bonding patterns, a region of the protein important for NAD(+) binding.	Hydrogen	139-147	adenosylhomocysteinase	Homo sapiens	70-74
32886808-1	2020	Catalytic dehalogenation of aromatic halides using isotopic hydrogen gas is an important strategy for labelling pharmaceuticals, biochemicals, environmental agents, etc.	Hydrogen	60-68	gastrin	Homo sapiens	69-72
25003317-6	2014	At later time points (&gt;=1h), MG induces GSK3 deactivation which is dissipated by siRNA silencing of SGK.	Hydrogen	27-29	glycogen synthase kinase 3 beta	Mus musculus	43-47
32886808-2	2020	To extend, improve and further understand this process, studies have been carried out on the scrambling of deuterium isotope with protium during the catalytic deuterodehalogenation of model aryl chlorides using deuterium gas and a palladium on carbon catalyst in tetrahydrofuran solution.	Hydrogen	130-137	gastrin	Homo sapiens	221-224
24939171-5	2014	H2 S promotes the phosphorylation of AKT and ERK and increases the expression of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1).	Hydrogen	0-2	vascular endothelial growth factor A	Rattus norvegicus	81-115
24939171-5	2014	H2 S promotes the phosphorylation of AKT and ERK and increases the expression of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1).	Hydrogen	0-2	vascular endothelial growth factor A	Rattus norvegicus	117-121
24939171-5	2014	H2 S promotes the phosphorylation of AKT and ERK and increases the expression of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1).	Hydrogen	0-2	angiopoietin 1	Rattus norvegicus	127-141
32938720-5	2020	The Arg144Cys variation in the *2 complex disrupts the hydrogen-bonding interactions that were observed between the side chain of arginine and neighboring residues in the losartan complex of CYP2C9 and the wild-type (WT) ligand-free structure.	Hydrogen	55-63	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	191-197
24939171-5	2014	H2 S promotes the phosphorylation of AKT and ERK and increases the expression of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1).	Hydrogen	0-2	angiopoietin 1	Rattus norvegicus	143-148
24939171-7	2014	H2 S-treated astrocytes increased VEGF and Ang-1 expression, and the inhibition of phosphatidylinositide 3-kinase (PI3K)/AKT signaling by LY294002 significantly reduced H2 S-induced VEGF and Ang-1 expression in astrocytes.	Hydrogen	0-2	vascular endothelial growth factor A	Rattus norvegicus	34-38
24939171-7	2014	H2 S-treated astrocytes increased VEGF and Ang-1 expression, and the inhibition of phosphatidylinositide 3-kinase (PI3K)/AKT signaling by LY294002 significantly reduced H2 S-induced VEGF and Ang-1 expression in astrocytes.	Hydrogen	0-2	angiopoietin 1	Rattus norvegicus	43-48
24939171-7	2014	H2 S-treated astrocytes increased VEGF and Ang-1 expression, and the inhibition of phosphatidylinositide 3-kinase (PI3K)/AKT signaling by LY294002 significantly reduced H2 S-induced VEGF and Ang-1 expression in astrocytes.	Hydrogen	0-2	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	83-113
24939171-7	2014	H2 S-treated astrocytes increased VEGF and Ang-1 expression, and the inhibition of phosphatidylinositide 3-kinase (PI3K)/AKT signaling by LY294002 significantly reduced H2 S-induced VEGF and Ang-1 expression in astrocytes.	Hydrogen	0-2	vascular endothelial growth factor A	Rattus norvegicus	182-186
24939171-7	2014	H2 S-treated astrocytes increased VEGF and Ang-1 expression, and the inhibition of phosphatidylinositide 3-kinase (PI3K)/AKT signaling by LY294002 significantly reduced H2 S-induced VEGF and Ang-1 expression in astrocytes.	Hydrogen	0-2	angiopoietin 1	Rattus norvegicus	191-196
32997862-13	2020	Western blot revealed that hydrogen treatment regulated loss of the transmembrane protein ZO-1.	Hydrogen	27-35	tight junction protein 1	Rattus norvegicus	90-94
33143042-6	2020	Moreover, the gas separation measurements showed that the C7-P2.8-T250 membrane with the highest H2/CO2 selectivity of 4.0 and sufficient hydrogen permeance of 1124.61 GPU exhibited the Knudsen diffusion mechanism and crossed the Robeson trade-off limit.	Hydrogen	138-146	gastrin	Homo sapiens	14-17
25218972-7	2014	ACE inhibition by SCW (12%) was improved through hydrolysis, reaching maximal values (55% inhibition) in 4h, although 42% inhibition was already observed after 1h hydrolysis.	Hydrogen	160-162	angiotensin-converting enzyme	Ovis aries	0-3
25354530-4	2014	The crystal structure of human IL-23 in complex with an affinity-matured Alphabody reveals how the variable interhelical groove of the scaffold uniquely targets a large epitope on the p19 subunit of IL-23 to harness fully the hydrophobic and hydrogen-bonding potential of tryptophan and tyrosine residues contributed by p19 and the Alphabody, respectively.	Hydrogen	242-250	interleukin 23 subunit alpha	Homo sapiens	31-36
25354530-4	2014	The crystal structure of human IL-23 in complex with an affinity-matured Alphabody reveals how the variable interhelical groove of the scaffold uniquely targets a large epitope on the p19 subunit of IL-23 to harness fully the hydrophobic and hydrogen-bonding potential of tryptophan and tyrosine residues contributed by p19 and the Alphabody, respectively.	Hydrogen	242-250	interleukin 23 subunit alpha	Homo sapiens	184-187
25354530-4	2014	The crystal structure of human IL-23 in complex with an affinity-matured Alphabody reveals how the variable interhelical groove of the scaffold uniquely targets a large epitope on the p19 subunit of IL-23 to harness fully the hydrophobic and hydrogen-bonding potential of tryptophan and tyrosine residues contributed by p19 and the Alphabody, respectively.	Hydrogen	242-250	interleukin 23 subunit alpha	Homo sapiens	199-204
33195109-0	2020	V-Doped CoP Nanosheet Arrays as Highly Efficient Electrocatalysts for Hydrogen Evolution Reaction in Both Acidic and Alkaline Solutions.	Hydrogen	70-78	caspase recruitment domain family member 16	Homo sapiens	8-11
25354530-4	2014	The crystal structure of human IL-23 in complex with an affinity-matured Alphabody reveals how the variable interhelical groove of the scaffold uniquely targets a large epitope on the p19 subunit of IL-23 to harness fully the hydrophobic and hydrogen-bonding potential of tryptophan and tyrosine residues contributed by p19 and the Alphabody, respectively.	Hydrogen	242-250	interleukin 23 subunit alpha	Homo sapiens	320-323
33113947-3	2020	Strongly deshielded C-O-O-H 1H-NMR resonances of diastereomeric endo-hydroperoxides in the region of 8.8 to 9.6 ppm were shown to be due to intramolecular hydrogen bonding interactions of the hydroperoxide proton with an oxygen atom of the five-member endo-peroxide ring.	Hydrogen	28-30	mannosidase endo-alpha	Homo sapiens	64-68
24796962-5	2014	The fast evolution of some hydrogen bonds of bovine insulin in the presence of the 1.0 V/nm electric field shows that different microwaves could either speed up protein folding or destroy the secondary structure of globular proteins deponding on the intensity of the external electric field.	Hydrogen	27-35	insulin	Bos taurus	52-59
25029675-8	2014	Myoglobin increased (p &lt; 0.05) in all 3 conditions at post and 1h compared with pre, showing lower values at 1h (p &lt; 0.05) for the carbohydrate and a trend (p = 0.060) for multi-ingredient compared with the placebo condition (211.4 +- 127.2 ng mL(-1) and 239.4 +- 103.8 ng mL(-1) vs. 484.6 +- 200.0 ng mL(-1), respectively).	Hydrogen	66-68	myoglobin	Homo sapiens	0-9
33113947-3	2020	Strongly deshielded C-O-O-H 1H-NMR resonances of diastereomeric endo-hydroperoxides in the region of 8.8 to 9.6 ppm were shown to be due to intramolecular hydrogen bonding interactions of the hydroperoxide proton with an oxygen atom of the five-member endo-peroxide ring.	Hydrogen	28-30	mannosidase endo-alpha	Homo sapiens	252-256
25029675-8	2014	Myoglobin increased (p &lt; 0.05) in all 3 conditions at post and 1h compared with pre, showing lower values at 1h (p &lt; 0.05) for the carbohydrate and a trend (p = 0.060) for multi-ingredient compared with the placebo condition (211.4 +- 127.2 ng mL(-1) and 239.4 +- 103.8 ng mL(-1) vs. 484.6 +- 200.0 ng mL(-1), respectively).	Hydrogen	112-114	myoglobin	Homo sapiens	0-9
33113947-3	2020	Strongly deshielded C-O-O-H 1H-NMR resonances of diastereomeric endo-hydroperoxides in the region of 8.8 to 9.6 ppm were shown to be due to intramolecular hydrogen bonding interactions of the hydroperoxide proton with an oxygen atom of the five-member endo-peroxide ring.	Hydrogen	155-163	mannosidase endo-alpha	Homo sapiens	64-68
33113947-3	2020	Strongly deshielded C-O-O-H 1H-NMR resonances of diastereomeric endo-hydroperoxides in the region of 8.8 to 9.6 ppm were shown to be due to intramolecular hydrogen bonding interactions of the hydroperoxide proton with an oxygen atom of the five-member endo-peroxide ring.	Hydrogen	155-163	mannosidase endo-alpha	Homo sapiens	252-256
32531362-5	2020	Structural analysis reveals that the segment glutamine23-lysine32 juxtaposed to the resolving cysteine (CR) of Ahp1 moves inward to generate a compact structure upon peroxidatic cysteine (CP) overoxidation, resulting in the breakdown of several conserved hydrogen bonds formed by Ahp1-Trx2 complex interaction.	Hydrogen	255-263	thioredoxin 2	Homo sapiens	285-289
25044698-3	2014	On Pt(111), dehydrogenation of perhydro-N-ethylcarbazole, H12 -NEC, starts with activation of the hydrogen atoms at the pyrrole unit, yielding H8 -NEC as the first stable reaction intermediate at ~340 K, followed by further dehydrogenation to NEC at ~380 K. Above 390 K, dealkylation starts, yielding carbazole as an undesired byproduct.	Hydrogen	14-22	H1.2 linker histone, cluster member	Homo sapiens	58-61
24967689-11	2014	Furthermore, this work defines a novel mechanism of biological activity of hydrogen by directly increasing the AChE activity.	Hydrogen	75-83	acetylcholinesterase	Rattus norvegicus	111-115
32535203-7	2020	Further insights into the thermodynamic parameters suggested that MARK4-CHA complex formation is driven by hydrogen bonding, thus making a specific mode of interaction.	Hydrogen	107-115	microtubule affinity regulating kinase 4	Homo sapiens	66-71
32956590-10	2020	The molecular docking results further confirmed that these compounds could interact with CP through hydrogen bonding.	Hydrogen	100-108	ceruloplasmin	Homo sapiens	89-91
24605822-6	2014	Hydrogen bonding of the side-chain hydroxyl group with a backbone carbonyl oxygen aligns the singly occupied pi orbital on the beta-carbon and the N-Calpha bond, leading to low-barrier beta-cleavage of the N-Calpha bond.	Hydrogen	0-8	CEA cell adhesion molecule 6	Homo sapiens	147-155
24605822-6	2014	Hydrogen bonding of the side-chain hydroxyl group with a backbone carbonyl oxygen aligns the singly occupied pi orbital on the beta-carbon and the N-Calpha bond, leading to low-barrier beta-cleavage of the N-Calpha bond.	Hydrogen	0-8	CEA cell adhesion molecule 6	Homo sapiens	206-214
24925626-0	2014	Photocatalytic hydrogen evolution by oleic acid-capped CdS, CdSe, and CdS0.75Se0.25 alloy nanocrystals.	Hydrogen	15-23	CDP-diacylglycerol synthase 1	Homo sapiens	55-58
24925626-1	2014	Photocatalytic generation of hydrogen by using oleic acid-capped CdS, CdSe, and CdS(0.75)Se(0.25) alloy nanocrystals (quantum dots) has been investigated under visible-light irradiation by employing Na(2)S and Na(2)SO(3) as hole scavengers.	Hydrogen	29-37	CDP-diacylglycerol synthase 1	Homo sapiens	65-68
24925626-1	2014	Photocatalytic generation of hydrogen by using oleic acid-capped CdS, CdSe, and CdS(0.75)Se(0.25) alloy nanocrystals (quantum dots) has been investigated under visible-light irradiation by employing Na(2)S and Na(2)SO(3) as hole scavengers.	Hydrogen	29-37	CDP-diacylglycerol synthase 1	Homo sapiens	70-73
33066526-7	2020	Manufacturing problems include the difficulty of injecting dry nanoparticles uniformly, increasing the output of the process to reduce cost, and safely handling the hydrogen gas generated in the process.	Hydrogen	165-173	gastrin	Homo sapiens	174-177
32497919-0	2020	Contrallable synthesis of peony-like porous Mn-CoP nanorod electrocatalyst for highly efficient hydrogen evolution in acid and alkaline.	Hydrogen	96-104	caspase recruitment domain family member 16	Homo sapiens	47-50
25202942-6	2014	This specific electronic behaviour is postulated to originate from the electrostatic repulsion of diamantane-C60 molecules due to positively charged terminal hydrogen atoms on the diamondoid interacting with the top electrode (scanning tip) at various bias voltages.	Hydrogen	158-166	TOR signaling pathway regulator	Homo sapiens	236-239
32497919-5	2020	Density Functional Theory (DFT) calculations illustrate that Mn doping indeed improve electron transfer, and makes the thermo-neutral hydrogen adsorption free energy (DeltaGH*) of CoP on the surface of (0 1 1) sharply close to zero, which is very conducive to the adsorption and desorption of hydrogen, thereby making Mn-CoP PMFs/CC with significant enhanced electrocatalytic HER performance.	Hydrogen	134-142	caspase recruitment domain family member 16	Homo sapiens	180-183
24972352-2	2014	According to the analysis of experimental and theoretical data, we concluded that hydrophobic interactions and hydrogen bonding primarily mediated the binding processes of bisphenol S with bovine serum albumin and DNA.	Hydrogen	111-119	albumin	Bos taurus	196-209
32497919-5	2020	Density Functional Theory (DFT) calculations illustrate that Mn doping indeed improve electron transfer, and makes the thermo-neutral hydrogen adsorption free energy (DeltaGH*) of CoP on the surface of (0 1 1) sharply close to zero, which is very conducive to the adsorption and desorption of hydrogen, thereby making Mn-CoP PMFs/CC with significant enhanced electrocatalytic HER performance.	Hydrogen	293-301	caspase recruitment domain family member 16	Homo sapiens	180-183
32505004-3	2020	The EDA-reduced Cu-rGH hydrogel with an 11.3% Cu NPs mass ratio exhibits the best hydrogen evolution rate (16.92 mmol g-1 h-1).	Hydrogen	82-90	H1.5 linker histone, cluster member	Homo sapiens	122-125
25138439-3	2014	The photocatalysis results indicated that the CdS with likely photochemically reduced Pd and Ni, which were initially immobilized via ethanedithiol (EDT) as a linker, were highly efficient for photocatalytic hydrogen evolution from Na2S-Na2SO3-containing aqueous solutions.	Hydrogen	208-216	CDP-diacylglycerol synthase 1	Homo sapiens	46-49
32812680-2	2020	A large-scale analysis of Hsp90alpha:inhibitor structures shows that inhibitor hydrogen-bonding to a conserved aspartate (D93 in Hsp90alpha) stands out as most universal among Hsp90 inhibitors.	Hydrogen	79-87	heat shock protein 90 alpha family class A member 1	Homo sapiens	26-36
24781421-8	2014	Acute myocarditis was associated with the highest concentrations of hs-TnT compared to other groups (AM 262.9 pg/ml (61.4-884.2); CM 20.4 pg/ml (15.6-20.4); NM 19.5 pg/ml (13.8-50.7); p &lt; 0.0001).	Hydrogen	68-70	troponin T1, slow skeletal type	Homo sapiens	71-74
24992072-4	2014	Docking analysis of representative compound 4j into SIRT2 indicated that the interaction with receptor was primarily due to hydrogen bonding and pi-pi stacking interactions.	Hydrogen	124-132	sirtuin 2	Homo sapiens	52-57
25093931-3	2014	Herein we report a new series of polymethoxy benzamides, whose lipophilicity was modulated through the establishment of an intramolecular hydrogen bond (IMHB) which allows reaching of P-gp inhibitory activity at the submicromolar IC50 level.	Hydrogen	138-146	phosphoglycolate phosphatase	Homo sapiens	184-188
25452862-6	2014	As compared with NGT 1h-low, NGT 1h-high and IGT subjects exhibited significantly higher body mass index (BMI), triglycerides, high sensitivity C reactive protein, ALT, GGT, and hepatic insulin resistance (IR), assessed by the liver IR index, as well as lower high density lipoprotein, and insulin-like growth factor-1 (IGF-1) levels.	Hydrogen	33-35	gamma-glutamyltransferase light chain family member 3	Homo sapiens	169-172
24939758-4	2014	The computational study of 3i suggested that the major interactions between 3i and IDO protein are the coordination of sulfone and heme iron, the hydrogen bonding and hydrophobic interactions between 3i and IDO.	Hydrogen	146-154	indoleamine 2,3-dioxygenase 1	Homo sapiens	83-86
24939758-4	2014	The computational study of 3i suggested that the major interactions between 3i and IDO protein are the coordination of sulfone and heme iron, the hydrogen bonding and hydrophobic interactions between 3i and IDO.	Hydrogen	146-154	indoleamine 2,3-dioxygenase 1	Homo sapiens	207-210
24981731-4	2014	The exchange of hydrogen versus fluorine on the peripheral phenyl groups show a notable influence on both the electronic and crystallographic natures of the resulting TTFs: 1) lowering both the HOMO and the LUMO energy levels, 2) modulating the electrochemical properties by regioselective and/or the degree of fluorination, 3) enhancing the driving forces of stacking by multiple fluorine interactions (F   S, C F   pi/piF , C F   F C, and C F   H).	Hydrogen	16-24	PIF1 5'-to-3' DNA helicase	Homo sapiens	420-423
24949666-4	2014	The results show that hydrogen abstraction dominates over the addition route in the CH2 NH + OH reaction, and that the major primary product is HCN, while HNC and CHONH2 are minor primary products.	Hydrogen	22-30	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	144-147
24852189-5	2014	Co-crystals of CBr4 with (Pr4N)NCS show two modes (C-Br   S-C and C-Br   N C) of halogen bonding, while tribromoacetamide molecules form C-Br   S-C halogen bonds and N-H   N C hydrogen bonds with thiocyanate anions.	Hydrogen	176-184	carbonyl reductase 4	Homo sapiens	15-19
24853320-9	2014	Two derivatives, bearing either a 1,3-diaminopropyl or a 1H-benzotriazolyl residue, showed a BChE selective inhibition in the single-digit micro-molar range without being cytotoxic up to 30muM.	Hydrogen	57-59	butyrylcholinesterase	Homo sapiens	93-97
24793774-6	2014	LIGPLOTs indicated that competitive inhibitory peptides were predicted to have both hydrophobic and hydrogen bond interactions with the active site of DPP-IV.	Hydrogen	100-108	dipeptidyl peptidase 4	Homo sapiens	151-157
24959670-3	2014	In vivo experiments and hydrogen-deuterium exchange (HDX) with tandem mass spectrometry (MS) studies showed that NT-UCH-L1 is readily aggregated and degraded, and has more flexible structure than UCH-L1.	Hydrogen	24-32	ubiquitin C-terminal hydrolase L1	Homo sapiens	116-122
24792393-5	2014	Concurrently, when spicatoside A was administered immediately or 1h after the acquisition trial, hippocampal mBDNF levels were similar or significantly increased at 9h after the acquisition trial compared to levels at 6h.	Hydrogen	65-67	brain derived neurotrophic factor	Mus musculus	109-114
24621326-3	2014	Then MD simulations demonstrate the hydrogen purification process of the PG-ESX membrane.	Hydrogen	36-44	E74 like ETS transcription factor 3	Homo sapiens	76-79
24629044-10	2014	Moreover, H2 S could also reduce cigarette smoking-induced inflammation by inhibiting the phosphorylation of ERK 1/2, JNK and p38 MAPKs and negatively regulating NF-kappaB activation.	Hydrogen	10-12	mitogen-activated protein kinase 8	Rattus norvegicus	118-121
24729482-1	2014	Nanoparticles of cobalt phosphide, CoP, have been prepared and evaluated as electrocatalysts for the hydrogen evolution reaction (HER) under strongly acidic conditions (0.50 M H2SO4, pH 0.3).	Hydrogen	101-109	caspase recruitment domain family member 16	Homo sapiens	35-38
24729482-4	2014	The CoP/Ti electrodes were stable over 24 h of sustained hydrogen production in 0.50 M H2SO4.	Hydrogen	57-65	caspase recruitment domain family member 16	Homo sapiens	4-7
24751523-9	2014	Study of 3D model suggested that Lys355 was involved in formation of a Hydrogen bond with OE1 of Glu284.	Hydrogen	71-79	EBF transcription factor 1	Homo sapiens	90-93
24811633-4	2014	Using the Assisted Model Building with Energy Refinement induced dipole polarizable protein force field, the QM/MM/C style MP2 method is used to study the hydrogen bonding distances and strengths of the photoactive yellow protein chromopore in the wild type and the Glu46Gln mutant.	Hydrogen	155-163	tryptase pseudogene 1	Homo sapiens	123-126
24704197-4	2014	The binding pose of 21b generated by docking analysis reveals that it fits well into the ATP binding cavity of ALK5 by forming several hydrogen bond interactions.	Hydrogen	135-143	transforming growth factor beta receptor 1	Homo sapiens	111-115
24644007-0	2014	Visible-light-induced generation of H2 by nanocomposites of few-layer TiS2 and TaS2 with CdS nanoparticles.	Hydrogen	36-38	CDP-diacylglycerol synthase 1	Homo sapiens	89-92
24644007-6	2014	The amount of hydrogen evolved after 20 and 16 h for the CdS/TiS2 and CdS/TaS2 nanocomposites was 14,833 and 28,132 mumol, respectively, with turnover frequencies of 0.24 and 0.57 h(-1), respectively.	Hydrogen	14-22	CDP-diacylglycerol synthase 1	Homo sapiens	57-60
24644007-6	2014	The amount of hydrogen evolved after 20 and 16 h for the CdS/TiS2 and CdS/TaS2 nanocomposites was 14,833 and 28,132 mumol, respectively, with turnover frequencies of 0.24 and 0.57 h(-1), respectively.	Hydrogen	14-22	CDP-diacylglycerol synthase 1	Homo sapiens	70-73
25079642-10	2014	The blue-shifted soret band in the UV-Vis spectra and changes in the excitation/emission matrix fluorescence spectra demonstrated that Cyt c interacted with HA to form organic complexes via electrostatic or hydrogen-bonding interactions.	Hydrogen	207-215	cytochrome c, somatic	Equus caballus	135-140
18931049-6	2009	The recent generation of knockout mice for three members of the sodium-hydrogen regulatory factor (NHERF) family of PDZ adaptor proteins, namely NHERF1 (EBP50), NHERF2 (E3KARP) and NHERF3 (PDZK1), has helped to explain why NHERF1 is essential for both normal and mutant CFTR function.	Hydrogen	71-79	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	145-151
18931049-6	2009	The recent generation of knockout mice for three members of the sodium-hydrogen regulatory factor (NHERF) family of PDZ adaptor proteins, namely NHERF1 (EBP50), NHERF2 (E3KARP) and NHERF3 (PDZK1), has helped to explain why NHERF1 is essential for both normal and mutant CFTR function.	Hydrogen	71-79	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	153-158
18996721-2	2009	Here hydrogen/deuterium exchange electrospray ionization mass spectrometry (HDX-ESI-MS) has been used to compare the solution dynamics of beta(2)m in its MHC-1 bound state compared with those of beta(2)m as a free monomer.	Hydrogen	5-13	beta-2-microglobulin	Homo sapiens	138-146
19229930-3	2009	The hydrogen-coupled electron-transfer mechanism of C-H nitroxylation with the model electrophile NO(2)(+)...HNO(3) was verified computationally at the B3PW91 and MP2 levels of theory by utilizing the 6-31G(d) and cc-pVDZ basis sets.	Hydrogen	4-12	tryptase pseudogene 1	Homo sapiens	163-166
18393299-7	2009	In RAN-B polymorphs, the nitro group is involved in a strong intramolecular hydrogen bond responsible for the existence of a Z configuration in the enamine portion of the molecules.	Hydrogen	76-84	RAN, member RAS oncogene family	Homo sapiens	3-6
19057078-3	2008	The N atom in the C-2 side chain is protonated in both structures and is involved in the hydrogen-bonding networks.	Hydrogen	89-97	complement C2	Homo sapiens	18-21
18948185-3	2008	In this study, exposure of cells to various concentrations of BaP for 1h followed by UVA irradiation (2J/cm(2)) increased DNA damage and decreased cell viability.	Hydrogen	70-72	prohibitin 2	Homo sapiens	62-65
18937455-6	2008	Dynamic 1H NMR spectroscopic measurements and line-shape simulations suggested that the energy barrier of 10.0 kcal/mol (DeltaG++(A/B), 298 K) is required for the 1A/B interconversion, when CCl4 occupies the cavity of 1.	Hydrogen	8-10	C-C motif chemokine ligand 4	Homo sapiens	190-194
32812680-2	2020	A large-scale analysis of Hsp90alpha:inhibitor structures shows that inhibitor hydrogen-bonding to a conserved aspartate (D93 in Hsp90alpha) stands out as most universal among Hsp90 inhibitors.	Hydrogen	79-87	heat shock protein 90 alpha family class A member 1	Homo sapiens	129-139
24860381-7	2014	In the crystal, mol-ecules are linked via N-H O hydrogen bonds, forming hexa-gonal rings lying parallel to the ab plane.	Hydrogen	48-56	hexosaminidase subunit alpha	Homo sapiens	72-76
32812680-2	2020	A large-scale analysis of Hsp90alpha:inhibitor structures shows that inhibitor hydrogen-bonding to a conserved aspartate (D93 in Hsp90alpha) stands out as most universal among Hsp90 inhibitors.	Hydrogen	79-87	heat shock protein 90 alpha family class A member 1	Homo sapiens	26-31
32812680-8	2020	While aspartate and asparagine sidechains can both act as hydrogen bond acceptors, we show that a steric clash prevents the Hsp90 Asp93 Asn sidechain from adopting the necessary rotamer, whereas this steric restriction is absent in Topoisomerasese II.	Hydrogen	58-66	heat shock protein 90 alpha family class A member 1	Homo sapiens	124-129
32929017-6	2020	We show that a single additional hydrogen bond in Arabidopsis ARF1 confers high-affinity binding to individual DNA sites.	Hydrogen	33-41	auxin response factor 1	Arabidopsis thaliana	62-66
24567332-6	2014	Using multiple methods, including pull-down assays, fluorescence polarization, hydrogen/deuterium exchange, and site-directed mutagenesis, we defined the binding activities and specificities of Tomm34 TPR domains toward Hsp70 and Hsp90.	Hydrogen	79-87	translocase of outer mitochondrial membrane 34	Homo sapiens	194-200
32974652-3	2020	In this work, we present structural insights for the recognition of DR5 and DR0 elements by RXR-RAR heterodimer using x-ray crystallography, small angle x-ray scattering, and hydrogen/deuterium exchange coupled to mass spectrometry.	Hydrogen	175-183	TNF receptor superfamily member 10b	Homo sapiens	68-71
23420131-0	2014	1H, 13C, and 15N backbone and side-chain chemical shift assignment of the toxin Doc in the unbound state.	Hydrogen	0-2	type II toxin-antitoxin system death-on-curing family toxin	Escherichia phage P1	80-83
23494870-0	2014	Backbone 1H, 13C and 15N resonance assignment of the C-terminal EGF-cbEGF pair of LTBP1 and flanking residues.	Hydrogen	9-11	latent transforming growth factor beta binding protein 1	Homo sapiens	82-87
18972510-0	2008	Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	133-141	glucosylceramidase beta	Homo sapiens	106-129
32510813-3	2020	We show the two-step hydrogenation of dimethyl acetylenedicarboxylate with para-enriched hydrogen gas in conventional glass NMR tubes, as well as in a titanium tube.	Hydrogen	21-29	gastrin	Homo sapiens	98-101
18708561-7	2008	This suggests a major remodeling of the photosystem II light-harvesting complex as well as an important function of LHCBM9 under sulfur starvation and photobiological hydrogen production.	Hydrogen	167-175	uncharacterized protein	Chlamydomonas reinhardtii	116-122
18775757-6	2008	Urocortin 2 at a dose of 2microg showed a byphasic action in increase in colon temperature having the first peak between 30 min and 1h and the second peak at 4h following treatment.	Hydrogen	132-134	urocortin 2	Rattus norvegicus	0-11
23649688-0	2014	1H, 13C and 15N resonance assignments for the fibrillin-1 EGF2-EGF3-hybrid1-cbEGF1 four-domain fragment.	Hydrogen	0-2	fibrillin 1	Homo sapiens	46-57
32927791-6	2020	A VP1 P208L mutation was observed in the virus using the JMJD6 receptor during cell adaptation, enabling the interaction with JMJD6 through the formation of a new hydrogen bond with JMJD6 residue 300.	Hydrogen	163-171	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	57-62
18680750-6	2008	Binding of p19 to p40 is mediated primarily by an arginine residue on helix D of p19 that forms an extensive charge and hydrogen-bonding network with residues at the base of a pocket on p40.	Hydrogen	120-128	interleukin 23 subunit alpha	Homo sapiens	11-14
18680750-6	2008	Binding of p19 to p40 is mediated primarily by an arginine residue on helix D of p19 that forms an extensive charge and hydrogen-bonding network with residues at the base of a pocket on p40.	Hydrogen	120-128	interleukin 23 subunit alpha	Homo sapiens	81-84
32927791-6	2020	A VP1 P208L mutation was observed in the virus using the JMJD6 receptor during cell adaptation, enabling the interaction with JMJD6 through the formation of a new hydrogen bond with JMJD6 residue 300.	Hydrogen	163-171	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	126-131
18819815-5	2008	Some of the synthesized 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins at the 5-position exhibited reasonable binding affinities into PTK with the hydrogen bond through their C(5)-NH moiety.	Hydrogen	158-166	protein tyrosine kinase 2 beta	Homo sapiens	145-148
24691535-3	2014	The interaction between HCN and rGO with oxygen-containing group can result in the formation of hydrogen bonds, N       H and O       H. The adsorption of HCN on rGO depends on the type and location of oxygen-containing group in rGO.	Hydrogen	96-104	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	24-27
24691535-3	2014	The interaction between HCN and rGO with oxygen-containing group can result in the formation of hydrogen bonds, N       H and O       H. The adsorption of HCN on rGO depends on the type and location of oxygen-containing group in rGO.	Hydrogen	96-104	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	155-158
32927791-6	2020	A VP1 P208L mutation was observed in the virus using the JMJD6 receptor during cell adaptation, enabling the interaction with JMJD6 through the formation of a new hydrogen bond with JMJD6 residue 300.	Hydrogen	163-171	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	126-131
33195011-6	2020	The residues including Asp70, Ser79, Trp82, Gly116, Thr120, Tyr332, and His438 were identified to play major roles in the stabilization of tacrine in the pocket of BChE, where hydrogen bonding and pi-pi interactions are significant factors.	Hydrogen	176-184	butyrylcholinesterase	Homo sapiens	164-168
18763825-3	2008	This reversal is attributed to the formation of a C-H...pi hydrogen bond between the C-H unit of the C8a angular position and the benzene ring of the alkylating reagent.	Hydrogen	59-67	complement C8 alpha chain	Homo sapiens	101-104
24722415-5	2014	Conversion of Cys143, which does not make direct hydrogen bonds with GlcNAc, to Ser (i.e., C143S) had the least affect on the enzymatic activity of NAGK.	Hydrogen	49-57	N-acetylglucosamine kinase	Rattus norvegicus	148-152
32824192-0	2020	Oxalic Acid as a Hydrogen Donor for the Hydrodesulfurization of Gas Oil and Deoxygenation of Rapeseed Oil Using Phonolite-Based Catalysts.	Hydrogen	17-25	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	64-67
24722415-6	2014	Conversion of Asn36, which plays a role in domain closure by making a hydrogen bond with GlcNAc, to Ala (i.e., N36A) mildly reduced NAGK enzyme activity.	Hydrogen	70-78	N-acetylglucosamine kinase	Rattus norvegicus	132-136
24606199-0	2014	Imidazole C-2 hydrogen/deuterium exchange reaction at histidine for probing protein structure and function with matrix-assisted laser desorption ionization mass spectrometry.	Hydrogen	14-22	complement C2	Homo sapiens	10-13
18727697-7	2008	The transplant induced upregulation in the inflammatory mediators CCL2, IL-1 beta, IL-6 and TNF-alpha were mitigated by hydrogen.	Hydrogen	120-128	C-C motif chemokine ligand 2	Homo sapiens	66-70
32824192-4	2020	The present work reports the use of oxalic acid as a hydrogen donor for the catalytic hydrodesulfurization of atmospheric gas oil and the deoxygenation of rapeseed oil at 350  C. For this process, one commercial NiW/SiO2-Al2O3 solid and two NiW/modified phonolite catalysts were used, namely Ni (5%) W (10%)/phonolite treated with HCl, and Ni (5%) W (10%)/phonolite treated with oxalic acid.	Hydrogen	53-61	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	122-125
32746924-6	2020	The epitope of 32A9 was located in the region of the GPC3 protein core close to the modification sites of the HS chain and outside of the Wnt-binding site of GPC3.	Hydrogen	110-112	glypican 3	Homo sapiens	53-57
17434239-0	2008	Age related changes in brain metabolites observed by 1H MRS in APP/PS1 mice.	Hydrogen	53-55	presenilin 1	Mus musculus	67-70
18636091-4	2008	Within their ligand binding pockets, NR3A and NR3B have strikingly different hydrogen bonding networks and solvent structures from those found in NR1, and fail to undergo a conformational rearrangement observed in NR1 upon binding the partial agonist ACPC.	Hydrogen	77-85	glutamate ionotropic receptor NMDA type subunit 3A	Homo sapiens	37-41
24554615-3	2014	If a monohydrosilane was used as the hydrogen source, a selective reduction of (13) CO2 to a product mixture of only silylformates was observed.	Hydrogen	37-45	complement C2	Homo sapiens	84-87
32623889-5	2020	Unexpectedly, CCl4 was found not to be an inert solvent and, similar to CHCl3, forms hydrogen-/halogen-bonds (H-/X-bond) with t-BuOH.	Hydrogen	85-93	C-C motif chemokine ligand 4	Homo sapiens	14-18
24604200-4	2014	An Fe(IV)-oxo intermediate abstracts the hydrogen (H ) from C5, and tyrosine 165, a residue not visualized in the published structures of CarC lacking bound substrate, donates H  to the opposite face of the resultant radical.	Hydrogen	41-49	complement C5	Homo sapiens	60-80
18598024-5	2008	It crystallizes with one molecule of [N(PPh 3) 2]Cl, whereby complex 4 acts as an anion receptor and forms strong hydrogen bonds between the chloro and the hydroxyl groups.	Hydrogen	114-122	protein phosphatase 4 catalytic subunit	Homo sapiens	40-45
32775930-3	2020	Results show that with an increase of methane mole fraction in the hydrogen/methane system, the upper turning point (P 1-2, T 1-2) remains almost unchanged and the lower transition point (P 2-3, T 2-3) rotates counterclockwise around (P 1-2, T 1-2).	Hydrogen	67-75	prostaglandin E synthase 3	Homo sapiens	188-200
18262646-8	2008	1h after irradiation by the lethal doses 5 and 10 Gy we detected by Western blot a decrease in repair proteins Mre11, Rad50, and Nbs1.	Hydrogen	0-2	nibrin	Homo sapiens	129-133
18463096-5	2008	10C9 Fab has an extraordinarily large and deep binding pocket at the center of the variable region, where CTX3C-ABCD or CTX3C-ABCDE binds longitudinally in the pocket via hydrogen bonds and van der Waals interactions.	Hydrogen	171-179	FA complementation group B	Homo sapiens	5-8
24412302-8	2014	Post-docking intramolecular hydrogen bonding analysis shows water molecule mediated hydrogen bonding for N-terminal maltase glucoamylase and N-terminal sucrase isomaltase.	Hydrogen	28-36	sucrase-isomaltase	Rattus norvegicus	152-170
24412302-8	2014	Post-docking intramolecular hydrogen bonding analysis shows water molecule mediated hydrogen bonding for N-terminal maltase glucoamylase and N-terminal sucrase isomaltase.	Hydrogen	84-92	sucrase-isomaltase	Rattus norvegicus	152-170
24562861-0	2014	A B3LYP and MP2(full) theoretical investigation on the cooperativity effect between hydrogen-bonding and cation-molecule interactions and thermodynamic property in the 1: 2 (Na+: N-(Hydroxymethyl)acetamide) ternary complex.	Hydrogen	84-92	tryptase pseudogene 1	Homo sapiens	12-15
18392863-1	2008	Hydrogen exchange rates for backbone amide protons of oxidized Pseudomonas aeruginosa cytochrome c-551 (P. aeruginosa cytochrome c) have been measured in the presence of low concentrations of the denaturant guanidine hydrochloride.	Hydrogen	0-8	cytochrome c, somatic	Equus caballus	86-98
32618988-0	2020	Electronic structural regulation of CoP nanorods by the tunable incorporation of oxygen for enhanced electrocatalytic activity during the hydrogen evolution reaction.	Hydrogen	138-146	caspase recruitment domain family member 16	Homo sapiens	36-39
18392863-1	2008	Hydrogen exchange rates for backbone amide protons of oxidized Pseudomonas aeruginosa cytochrome c-551 (P. aeruginosa cytochrome c) have been measured in the presence of low concentrations of the denaturant guanidine hydrochloride.	Hydrogen	0-8	cytochrome c, somatic	Equus caballus	118-130
18373368-6	2008	The BSSE-corrected MP2/aug-cc-pvtz binding energy of -27.56 kcal/mol for the gas-phase acetate...phenol system has been classified as a short and strong hydrogen bond (SSHB).	Hydrogen	153-161	tryptase pseudogene 1	Homo sapiens	19-22
24438327-7	2014	Interestingly, the hydrogen-bond forming or equivalent residues in both E1 and E2 domains are mutational hot spots for connexin-linked human diseases.	Hydrogen	19-27	small nucleolar RNA, H/ACA box 73A	Homo sapiens	72-81
18373368-10	2008	Uncorrected MP2/aug-cc-pvtz hydrogen-bonding energies are more negative by up to 0.35 kcal/mol than the MP2/CBS values, and overestimate the CCSD(T)/CBS binding energies generally by up to 5% for the eight studied complexes in the gas phase.	Hydrogen	28-36	tryptase pseudogene 1	Homo sapiens	12-15
32602487-2	2020	Ru1, Ru2, Ru3 and Ru4 were characterized by ESI-MS, 1H NMR, 1H-1H COSY NMR and elemental analysis.	Hydrogen	52-54	Scm like with four mbt domains 1	Homo sapiens	0-3
18373368-13	2008	Good correlations (R2 = 0.918-0.958) for the in-environment MP2/aug-cc-pvtz and MP2/6-31+G* hydrogen-bonding energies facilitate the high-level prediction of these energies on the basis of relatively simple MP2/6-31+G* calculations.	Hydrogen	92-100	tryptase pseudogene 1	Homo sapiens	80-83
18373368-13	2008	Good correlations (R2 = 0.918-0.958) for the in-environment MP2/aug-cc-pvtz and MP2/6-31+G* hydrogen-bonding energies facilitate the high-level prediction of these energies on the basis of relatively simple MP2/6-31+G* calculations.	Hydrogen	92-100	tryptase pseudogene 1	Homo sapiens	80-83
26580033-0	2014	Benchmarking Hydrogen and Carbon NMR Chemical Shifts at HF, DFT, and MP2 Levels.	Hydrogen	13-21	tryptase pseudogene 1	Homo sapiens	69-72
32602487-2	2020	Ru1, Ru2, Ru3 and Ru4 were characterized by ESI-MS, 1H NMR, 1H-1H COSY NMR and elemental analysis.	Hydrogen	60-62	Scm like with four mbt domains 1	Homo sapiens	0-3
32602487-2	2020	Ru1, Ru2, Ru3 and Ru4 were characterized by ESI-MS, 1H NMR, 1H-1H COSY NMR and elemental analysis.	Hydrogen	60-62	Scm like with four mbt domains 1	Homo sapiens	0-3
24326768-1	2014	We report a simple but highly cooperative ensemble with CdS and MoS2 nanocrystals dispersed on graphene sheets: it is demonstrated that CdS nanocrystals can capture light energy and facilitate excited electron transfer to MoS2 for catalytic hydrogen production via the 2-D graphene which plays a key role as an efficient electron mediator.	Hydrogen	241-249	CDP-diacylglycerol synthase 1	Homo sapiens	56-59
18222015-6	2008	Ammonia treatment (1h, 5mM NH4Cl) evoked a substantial decrease of CNP-stimulated cGMP synthesis which was related to a decreased binding of CNP to NPR2 receptors, and depressed the CNP-dependent [Ca2+]i accumulation in these cells.	Hydrogen	19-21	natriuretic peptide receptor 2	Rattus norvegicus	148-152
32402248-5	2020	We examined PLCbeta2 dynamics on membranes using hydrogen-deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	49-57	interleukin 31 receptor A	Homo sapiens	12-20
24343278-2	2014	A highly efficient (24.8%, apparent quantum yield (AQY)) photocatalyst for visible light (lambda &gt; 400 nm) enabled solar hydrogen evolution can be realized by assembling CdS with Ti-MCM-48 cubic mesoporous materials in the absence of a noble metal co-catalyst.	Hydrogen	124-132	CDP-diacylglycerol synthase 1	Homo sapiens	173-176
32371396-2	2020	Here, using in vitro phosphorylation and refolding assays, analytical size-exclusion chromatography, and hydrogen/deuterium exchange MS, we found that TOMM34 associates with 14-3-3 proteins after its phosphorylation by protein kinase A (PKA).	Hydrogen	105-113	translocase of outer mitochondrial membrane 34	Homo sapiens	151-157
24383916-5	2014	Hydrogen-deuterium exchange combined with electrospray ionization mass spectrometry was further utilized to understand the details of the regional interaction mechanisms of alpha-Syn with lipid vesicles based on the polarity of the lipid head groups.	Hydrogen	0-8	synuclein alpha	Homo sapiens	173-182
32620778-4	2020	A hydrogen bond in the catalytic loop of DNMT3B causes a lower CpG specificity than DNMT3A, while the interplay of target recognition domain and homodimeric interface fine-tunes the distinct target selection between the two enzymes, with Lysine 777 of DNMT3B acting as a unique sensor of the +1 flanking base.	Hydrogen	2-10	DNA methyltransferase 3 beta	Homo sapiens	41-47
32620778-4	2020	A hydrogen bond in the catalytic loop of DNMT3B causes a lower CpG specificity than DNMT3A, while the interplay of target recognition domain and homodimeric interface fine-tunes the distinct target selection between the two enzymes, with Lysine 777 of DNMT3B acting as a unique sensor of the +1 flanking base.	Hydrogen	2-10	DNA methyltransferase 3 alpha	Homo sapiens	84-90
32620778-4	2020	A hydrogen bond in the catalytic loop of DNMT3B causes a lower CpG specificity than DNMT3A, while the interplay of target recognition domain and homodimeric interface fine-tunes the distinct target selection between the two enzymes, with Lysine 777 of DNMT3B acting as a unique sensor of the +1 flanking base.	Hydrogen	2-10	DNA methyltransferase 3 beta	Homo sapiens	252-258
32537002-8	2020	Mechanistically, molecular hydrogen decreased TLR4 and MyD88 expression levels whilst also decreasing p65 and NF-kappaB inhibitor phosphorylation.	Hydrogen	27-35	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	55-60
32537002-9	2020	In conclusion, molecular hydrogen exerted therapeutic effects against T2DM by improving hyperglycemia and inhibiting oxidative stress through mechanisms that are associated with the TLR4/MyD88/NF-kappaB signaling pathway.	Hydrogen	25-33	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	187-192
32070843-5	2020	Molecular docking further demonstrated that the interaction forces between ferulic acid and alpha-amylase/alpha-glucosidase were hydrogen bonds, with the binding energy of -5.30 to -5.10 and -5.70 kcal mol-1, respectively.	Hydrogen	129-137	sucrase-isomaltase	Homo sapiens	106-123
32648885-9	2020	The OXY and tyrosinase interaction occured mainly through van der Waals forces and a hydrogen bond between the -OH group and its amino acid residue.	Hydrogen	85-93	tyrosinase	Mus musculus	12-22
32184136-6	2020	Surprisingly, the hydrogen-deuterium exchange mass spectrometry results revealed that Nucb2 is divided into two parts: an N-terminal half with a stable mosaic-like structure and a disordered C-terminal half.	Hydrogen	18-26	nucleobindin 2	Homo sapiens	86-91
31378152-7	2020	These results suggested that hydrogen binding and van der Waals forces play a major role in the interaction between metal complexes with CT-DNA and BSA.	Hydrogen	29-37	albumin	Bos taurus	148-151
32604807-0	2020	Ruthenium Decorated Polypyrrole Nanoparticles for Highly Sensitive Hydrogen Gas Sensors Using Component Ratio and Protonation Control.	Hydrogen	67-75	gastrin	Homo sapiens	76-79
32604807-1	2020	Despite being highly flammable at lower concentrations and causing suffocation at higher concentrations, hydrogen gas continues to play an important role in various industrial processes.	Hydrogen	105-113	gastrin	Homo sapiens	114-117
32604807-3	2020	In this study, we found a nanocomposite comprising of ruthenium nanoclusters decorated on carboxyl polypyrrole nanoparticles (Ru_CPPy) to be successful in detecting hydrogen gas through a simple sonochemistry method.	Hydrogen	165-173	gastrin	Homo sapiens	174-177
32604807-6	2020	This material-based sensor electrode was highly sensitive (down to 0.5 ppm) toward hydrogen gas and had a fast response and recovery time under ambient conditions.	Hydrogen	83-91	gastrin	Homo sapiens	92-95
32501695-7	2020	In the present work, we have used NMR to characterize the rotational diffusion of the alpha-helical STAM2-UIM domain by measuring the 15N-R1, 15N-R2 and 1H-15N NOE relaxation parameters.	Hydrogen	153-155	signal transducing adaptor molecule 2	Homo sapiens	100-105
32656396-1	2020	5-Fluorouracil-nicotinamide (5-FU-NCM), a co-crystal with a 2D layer structure formed by hydrogen bonds, was synthesized by solvent evaporation and liquid phase-assisted grinding at room temperature.	Hydrogen	89-97	CWC22 spliceosome associated protein homolog	Homo sapiens	34-37
32418996-1	2020	Herein, we report a metal-organic framework featuring a binuclear copper unit, showing extraordinarily high catalytic activity (102.8 mmol g-1 h-1) for photodriven hydrogen generation, which is attributed to the synergistic catalytic effect between the two copper ions.	Hydrogen	164-172	H1.5 linker histone, cluster member	Homo sapiens	143-146
32412761-7	2020	Site-specific order parameters for the LC phase of CAGE-oct were obtained from the measurement of the partially averaged 13C-1H dipolar couplings (DCH) by cross-polarization (CP) build-up curves and DIPSHIFT experiments, and 1H-1H dipolar couplings (DHH) by DQ build-up curves.	Hydrogen	125-127	plexin A2	Homo sapiens	56-59
32412761-7	2020	Site-specific order parameters for the LC phase of CAGE-oct were obtained from the measurement of the partially averaged 13C-1H dipolar couplings (DCH) by cross-polarization (CP) build-up curves and DIPSHIFT experiments, and 1H-1H dipolar couplings (DHH) by DQ build-up curves.	Hydrogen	225-227	plexin A2	Homo sapiens	56-59
32412761-7	2020	Site-specific order parameters for the LC phase of CAGE-oct were obtained from the measurement of the partially averaged 13C-1H dipolar couplings (DCH) by cross-polarization (CP) build-up curves and DIPSHIFT experiments, and 1H-1H dipolar couplings (DHH) by DQ build-up curves.	Hydrogen	225-227	plexin A2	Homo sapiens	56-59
32596455-1	2020	The preferential oxidation of CO (PROX) in hydrogen-rich fuel gas streams is an attractive option to remove CO while effectively conserving energy and H2.	Hydrogen	43-51	pyruvate dehydrogenase complex component X	Homo sapiens	34-38
18295412-12	2008	CONCLUSIONS: CSF concentrations of the stress hormones norepinephrine and CRH differentially change after exposure to 1h of trauma-related audiovisual stimulation in chronic, combat-related PTSD.	Hydrogen	118-120	corticotropin releasing hormone	Homo sapiens	74-77
32520690-9	2021	Molecular docking model for the most active molecule exhibited promising bindings with AChE and BChE"s active site pertained to hydrophobic hydrogen bonds and positive ionizable interactions.	Hydrogen	140-148	butyrylcholinesterase	Homo sapiens	96-100
18260680-4	2008	1H NMR studies revealed that POC16 and POC20 exist in the compact structure with the pyranine nucleus wrapped with a long methylene chain in water.	Hydrogen	0-2	ubiquitin like modifier activating enzyme 1	Homo sapiens	39-44
32526899-6	2020	Molecular docking studies revealed that these compounds fit well into the sphingosine binding pocket of SphK1 and formed significant number of hydrogen bonds and van der Waals interactions.	Hydrogen	143-151	sphingosine kinase 1	Homo sapiens	104-109
17659831-3	2008	Photocatalytic decomposition of CCl4 may proceed via a two-electron transfer process that yields mainly CHCl3, Cl- and H2.	Hydrogen	119-121	C-C motif chemokine ligand 4	Homo sapiens	32-36
17659831-7	2008	About 68% of this hydrogen (6.5 mmol(gZrO2)(-1)) was consumed in the photocatalytic decomposition of CCl4.	Hydrogen	18-26	C-C motif chemokine ligand 4	Homo sapiens	101-105
32513959-5	2020	Hydrogen-deuterium exchange (HDX-MS) mapped onto a full structural model of the ligase revealed long-range allostery extending from the substrate through CUL5.	Hydrogen	0-8	cullin 5	Homo sapiens	154-158
18232676-4	2008	The difference in free energy in water as compared to that in CCl4 was expected and is the result of competition from surrounding water molecules that are capable of forming hydrogen bonds in the liquid water.	Hydrogen	174-182	C-C motif chemokine ligand 4	Homo sapiens	62-66
32504133-7	2020	Triple-recognition abilities of DMMIPs towards LMT-lyso-Gb3 mainly rely on the hydrogen bonding, electrostatic attraction, hydrophobic interaction, and boronate affinity.	Hydrogen	79-87	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	56-59
18232676-17	2008	Upon analyzing the water hydrogen-bonding patterns as a function of water concentration, we conclude that the differences in the rotational correlation times mainly result from the formation of water hydrogen-bonding networks as the water concentration is increased in liquid CCl4.	Hydrogen	25-33	C-C motif chemokine ligand 4	Homo sapiens	276-280
18232676-17	2008	Upon analyzing the water hydrogen-bonding patterns as a function of water concentration, we conclude that the differences in the rotational correlation times mainly result from the formation of water hydrogen-bonding networks as the water concentration is increased in liquid CCl4.	Hydrogen	200-208	C-C motif chemokine ligand 4	Homo sapiens	276-280
32368904-0	2020	High-Precision, Gas-Phase Hydrogen/Deuterium Exchange Kinetics by Mass Spectrometry Enabled by Exchange Standards.	Hydrogen	26-34	gastrin	Homo sapiens	16-19
18234505-6	2008	Two emission species in the both ETF may be hydrogen-bonding isomers, because isoalloxazine ring of FAD contains four hydrogen acceptors and one donor.	Hydrogen	118-126	TEA domain transcription factor 2	Homo sapiens	33-36
24158589-10	2014	Notably, the number of hydrogen bonds in ERCC1-XPF mutant complexes decreased in the molecular dynamic simulation periods.	Hydrogen	23-31	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	41-46
32368904-2	2020	In combination with other orthogonal techniques, such as gas-phase hydrogen/deuterium exchange (gHDX), MS is also capable of probing the structure of ions.	Hydrogen	67-75	gastrin	Homo sapiens	57-60
31782895-5	2020	Y-1-H and EMSA studies confirmed the binding of MYC2 with the 5" UTR region of P5CS1.	Hydrogen	2-5	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	48-52
24581800-6	2014	The results revealed that beta1-beta3 is more likely to form a di-polymer than beta1-beta1 based on molecular interaction analysis, including potential energy analysis, Van der Waals (VDW) energy analysis and electrostatic energy analysis, and in addition, consideration of the hydrogen bonds and hydrophobic contacts that are involved.	Hydrogen	278-286	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	32-37
17729279-8	2008	A series of threonines, which are characteristic for alpha-synuclein and perhaps a phosphorylation site, is also located at the hydrophobic/hydrophilic interface with their side chain often hydrogen bonded to the main-chain atom.	Hydrogen	190-198	synuclein alpha	Homo sapiens	53-68
18197679-3	2008	The macrocyclic backbone of the aza-beta3-cyclohexapeptides shows a highly ordered conformation that is sustained by a dense intramolecular H-bond network where all endocyclic NHs are hydrogen bonded, the side chains being projected in equatorial position around the macrocycle.	Hydrogen	184-192	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	36-41
32410504-7	2021	Among five marine compounds, C-1 (PubChem CID 11170714) exhibited good activity, interacting with the active site and surrounding residues, forming many hydrogen and hydrophobic interactions.	Hydrogen	153-161	c-1	None	29-32
18205361-1	2008	Competitive major carbon-carbon bond activation (CCA) and minor carbon-hydrogen bond activation (CHA) channels are identified in the reaction between rhodium(II) meso-tetramesitylporphyrin [Rh(II)(tmp)] (1) and 2,2,6,6-tetramethyl-piperidine-1-oxyl (TEMPO) (2).	Hydrogen	71-79	Rh blood group D antigen	Homo sapiens	190-196
24138169-0	2014	Dissecting the effect of RNA aptamer binding on the dynamics of plasminogen activator inhibitor 1 using hydrogen/deuterium exchange mass spectrometry.	Hydrogen	104-112	serpin family E member 1	Homo sapiens	64-97
32374318-0	2020	N-Promoted Ru1/TiO2 single-atom catalysts for photocatalytic water splitting for hydrogen production: a density functional theory study.	Hydrogen	81-89	Scm like with four mbt domains 1	Homo sapiens	11-14
24413068-7	2014	By exploring the X-ray co-crystal structure of NS-018 bound to JAK2, we identified unique hydrogen-bonding interactions between NS-018 and Gly993 as a plausible explanation for its JAK2V617F selectivity.	Hydrogen	90-98	Janus kinase 2	Mus musculus	63-67
18942697-6	2008	The equations are tested for an external set of 99 additional compounds including very different nitrogen bases such as ortho-substituted pyridines, polyazines and azoles.Theoretical calculations give a reliable estimation of hydrogen-bond basicity provided that the populations of the different isomers of the bases are taken into account by using the Boltzmann law, and that a specific halogen-bond interaction with the solvent CCl4 is considered for polybasic molecules.The pKHB scale can thus be extended to important classes of species experimentally inaccessible in CCl4, to polynitrogen compounds and to molecules of biological significance.	Hydrogen	226-234	C-C motif chemokine ligand 4	Homo sapiens	572-576
32374318-3	2020	Isolated Ru1 atoms act as active sites for the reduction of protons, and Ru1-N1/TiO2 has a hydrogen evolution activity comparable to that of Pd.	Hydrogen	91-99	Scm like with four mbt domains 1	Homo sapiens	73-76
17928567-8	2008	Dimeric histaprodifen was docked into the binding pocket of gpH(1)R. Hydrogen bonds and electrostatic interactions were detected between dimeric histaprodifen and Asp-116, Ser-120, Lys-187, Glu-190, and Tyr-432.	Hydrogen	69-77	gephyrin	Homo sapiens	60-63
32478126-5	2020	In addition, the photocatalytic activity of several organic and metalorganic photosensitizers in the hydrogen evolution reaction was experimentally investigated with NbP as the proton reduction catalyst.	Hydrogen	101-109	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	166-169
17696509-6	2007	Ab initio calculations (MP2/cc-pVDZ) are used as a guide in identifying both the type and location of hydrogen bonds present.	Hydrogen	102-110	tryptase pseudogene 1	Homo sapiens	24-27
17877336-3	2007	Six unresolved bands are also observed and assigned to the linear hydrogen-bound isomers of Al-HCN, Ga-HCN, and In-HCN corresponding to the fundamental CH stretching vibration and a combination band involving the CH stretch plus intermolecular stretch for each isomer.	Hydrogen	66-74	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	95-98
32376995-3	2020	The crystal structures of the complexes showed that they form a canonical hydrogen-bond network involving helix 12 in the LBD, which is thought to be essential for PPARalpha activation, as also observed for fibrates.	Hydrogen	74-82	peroxisome proliferator activated receptor alpha	Homo sapiens	164-173
17877336-3	2007	Six unresolved bands are also observed and assigned to the linear hydrogen-bound isomers of Al-HCN, Ga-HCN, and In-HCN corresponding to the fundamental CH stretching vibration and a combination band involving the CH stretch plus intermolecular stretch for each isomer.	Hydrogen	66-74	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	103-106
17877336-3	2007	Six unresolved bands are also observed and assigned to the linear hydrogen-bound isomers of Al-HCN, Ga-HCN, and In-HCN corresponding to the fundamental CH stretching vibration and a combination band involving the CH stretch plus intermolecular stretch for each isomer.	Hydrogen	66-74	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	103-106
18031619-10	2007	The hydrogen bond could also increase the stability of the whole complex, which might suggest that compound B had a suitable conformation in the tunnel-like active site of COX-1.	Hydrogen	4-12	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	172-177
32233396-5	2020	Here, we introduce a hydrogen bond-based poly[(N-isopropylacrylamide-co-4-(3-acryloylthioureido)benzoic acid0.2] (re-ferred to as PNI-co-ATBA0.2) as a bifunctional enrichment platform to solve this bottleneck problem.	Hydrogen	21-29	5', 3'-nucleotidase, cytosolic	Homo sapiens	130-133
17960914-2	2007	The X-ray crystal structure of the Rev1p-DNA-dCTP ternary complex showed that Rev1p utilizes an unusual mechanism of nucleotide incorporation whereby the template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydrogen bonds with the incoming dCTP.	Hydrogen	246-254	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	35-40
33659576-0	2020	Quantification of Fatty Acids in Mammalian Tissues by Gas Chromatography-Hydrogen Flame Ionization Detection.	Hydrogen	73-81	gastrin	Homo sapiens	54-57
17506115-0	2007	1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines.	Hydrogen	0-2	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	63-67
17705397-4	2007	The mechanistic selectivity and sensitivity of compound 1 to Cd2+ was discussed on the basis of fluorescence, 1H NMR, and mass spectroscopic results.	Hydrogen	110-112	CD2 molecule	Homo sapiens	61-64
17705402-1	2007	The oxidation of six derivatives of terfenadone by recombinant human CYP2J2 (CYP = cytochrome P450) was studied by high-performance liquid chromatography coupled to mass spectrometry (MS) using tandem MS techniques and by 1H NMR spectroscopy.	Hydrogen	222-224	peptidylprolyl isomerase G	Homo sapiens	69-72
33659576-3	2020	To quantify FAs in biological samples, gas chromatography-hydrogen flame ionization detection (GC-FID)-based methods have been used as highly robust and reliable techniques.	Hydrogen	58-66	gastrin	Homo sapiens	39-42
32270679-5	2020	These insights are extended to solar-driven hydrogen production using MoS3, MoP or RuO2 water reduction catalyst overlayers where it is found that the catalyst morphology strongly affects performance due to differences in charge extraction.	Hydrogen	44-52	opioid receptor mu 1	Homo sapiens	76-79
32340144-5	2020	g-C3N4/TiO2 by plasma can produce hydrogen at a rate of 219.9 mumol g-1 h-1 and completely degrade Rhodamine B (20mg L-1) in two hours.	Hydrogen	34-42	H1.5 linker histone, cluster member	Homo sapiens	72-75
31834467-3	2020	Hydrogen production increased as methane production decreased with decreasing HRT from 8 to 0.25 h. The maximum hydrogen yield of 3.2 +- 0.3 mL H2/g CODap (reported as mL H2 per gram of COD applied) and hydrogen production rate of 1951 +- 171 mL H2/day Lreactor were observed at the HRT of 0.25 h. The decrease in HRT from 8 to 0.25 h caused larger changes in the bacterial populations than the archaea populations.	Hydrogen	0-8	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	141-146
31834467-3	2020	Hydrogen production increased as methane production decreased with decreasing HRT from 8 to 0.25 h. The maximum hydrogen yield of 3.2 +- 0.3 mL H2/g CODap (reported as mL H2 per gram of COD applied) and hydrogen production rate of 1951 +- 171 mL H2/day Lreactor were observed at the HRT of 0.25 h. The decrease in HRT from 8 to 0.25 h caused larger changes in the bacterial populations than the archaea populations.	Hydrogen	0-8	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	168-173
31834467-3	2020	Hydrogen production increased as methane production decreased with decreasing HRT from 8 to 0.25 h. The maximum hydrogen yield of 3.2 +- 0.3 mL H2/g CODap (reported as mL H2 per gram of COD applied) and hydrogen production rate of 1951 +- 171 mL H2/day Lreactor were observed at the HRT of 0.25 h. The decrease in HRT from 8 to 0.25 h caused larger changes in the bacterial populations than the archaea populations.	Hydrogen	0-8	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	168-173
31834467-3	2020	Hydrogen production increased as methane production decreased with decreasing HRT from 8 to 0.25 h. The maximum hydrogen yield of 3.2 +- 0.3 mL H2/g CODap (reported as mL H2 per gram of COD applied) and hydrogen production rate of 1951 +- 171 mL H2/day Lreactor were observed at the HRT of 0.25 h. The decrease in HRT from 8 to 0.25 h caused larger changes in the bacterial populations than the archaea populations.	Hydrogen	112-120	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	141-146
31834467-3	2020	Hydrogen production increased as methane production decreased with decreasing HRT from 8 to 0.25 h. The maximum hydrogen yield of 3.2 +- 0.3 mL H2/g CODap (reported as mL H2 per gram of COD applied) and hydrogen production rate of 1951 +- 171 mL H2/day Lreactor were observed at the HRT of 0.25 h. The decrease in HRT from 8 to 0.25 h caused larger changes in the bacterial populations than the archaea populations.	Hydrogen	112-120	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	168-173
31834467-3	2020	Hydrogen production increased as methane production decreased with decreasing HRT from 8 to 0.25 h. The maximum hydrogen yield of 3.2 +- 0.3 mL H2/g CODap (reported as mL H2 per gram of COD applied) and hydrogen production rate of 1951 +- 171 mL H2/day Lreactor were observed at the HRT of 0.25 h. The decrease in HRT from 8 to 0.25 h caused larger changes in the bacterial populations than the archaea populations.	Hydrogen	112-120	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	168-173
31944516-5	2020	Density functional theory calculations indicate that the in situ reconstructed Sn/SnO x interface facilitates formic acid production by optimizing the binding of the reaction intermediate HCOO* while promotes Faradaic efficiency of C 1 products by suppressing the competitive hydrogen evolution reaction, resulting in high Faradaic efficiency, current density and stability of CO 2 RR at low overpotentials.	Hydrogen	276-284	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	232-235
31863720-0	2020	Boron-Induced Electronic-Structure Reformation of CoP Nanoparticles Drives Enhanced pH-Universal Hydrogen Evolution.	Hydrogen	97-105	caspase recruitment domain family member 16	Homo sapiens	50-53
31641820-8	2020	Our study concluded that P5H induced the death receptor, DR5 in HCT-116 and mitochondria-mediated apoptosis pathway in HT-29.	Hydrogen	25-28	TNF receptor superfamily member 10b	Homo sapiens	57-60
32220191-11	2020	Compared to the asthma model group, treatment with hydrogen significantly decreased the levels of IL-4 and IL-13 and increased the level of IFN-gamma in BALF ( P<0.05).	Hydrogen	51-59	interleukin 4	Mus musculus	98-102
32184751-9	2020	Furthermore, proton magnetic resonance spectroscopy (1H MRS), which provides a non-invasive measurement of brain biochemistry, has identified early neurochemical abnormalities in presymptomatic MAPT mutation carriers.	Hydrogen	53-55	microtubule associated protein tau	Homo sapiens	194-198
31843194-8	2020	To investigate the T18A induced switch in desensitisation we compared molecular dynamics simulations of the wild type and T18A P2X2 receptor which suggest that the differences in time course of desensitisation are due to structural destabilization of a hydrogen bond network of conserved residues in the proximity of T18.	Hydrogen	253-261	purinergic receptor P2X 2	Homo sapiens	127-131
32049494-1	2020	The critical bottleneck of electrocatalytic CO2 reduction reaction (CO2RR) lies in its low efficiency at high overpotential caused by competitive hydrogen evolution.	Hydrogen	146-154	complement C2	Homo sapiens	44-47
32070414-0	2020	JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability.	Hydrogen	41-43	lysine demethylase 3B	Homo sapiens	0-6
32070414-4	2020	We find that depletion of JMJD1B increases the protein levels of the histone chaperone tNASP leading to an accumulation of newly synthesized histones H3 and H4 at early steps of the histone maturation cascade, which perturbs chromatin assembly.	Hydrogen	157-159	lysine demethylase 3B	Homo sapiens	26-32
24410213-6	2014	The occurrence of this effect at low Ecm indicates that the long range charge and dipole-induced-multipole interactions of the colliding pair play a significant role in the dynamics of the exothermic H2O(+) + H2 (D2) reactions.	Hydrogen	200-202	multimerin 1	Homo sapiens	37-40
32060392-8	2020	In primary cortical cells S1P and LPA mobilize Ca2+ from internal stores via a mechanism sensitive to the S1P and LPA receptor antagonists Ex26, H2L5186303, or Ki16425.	Hydrogen	145-155	sphingosine-1-phosphate receptor 1	Mus musculus	106-126
24419388-11	2014	The inter-domain interaction of the Fbxo7 FP domain is much more extensive, featuring a larger contact surface area, better shape complementarity and more hydrophobic and hydrogen-bonding interactions.	Hydrogen	171-179	F-box protein 7	Homo sapiens	36-41
32104537-6	2020	Furthermore, H2 inhalation reduced the expression of Bcl-2-associated X protein (BAX) and caspase-3 while promoting the expression of Bcl-2, nuclear factor erythroid-2-related factor 2, and heme oxygenase-1 (HO-1).	Hydrogen	13-15	BCL2 associated X, apoptosis regulator	Rattus norvegicus	53-79
32104537-6	2020	Furthermore, H2 inhalation reduced the expression of Bcl-2-associated X protein (BAX) and caspase-3 while promoting the expression of Bcl-2, nuclear factor erythroid-2-related factor 2, and heme oxygenase-1 (HO-1).	Hydrogen	13-15	BCL2 associated X, apoptosis regulator	Rattus norvegicus	81-84
32046108-7	2020	Of these signaling changes predicted by ingenuity pathway analyses (IPA), the novel form also with the highest significance (-log(Benjamini-Hochberg (B-H)) p-value) was the EIF2 signaling upregulation.	Hydrogen	150-153	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	173-177
32029879-7	2020	Hydrogen abrogated ovalbumin sensitization and challenge-induced upregulation of glycolytic enzymes and hypoxia-inducible factor-1alpha, and downregulation of mitochondrial respiratory chain complexes and peroxisome proliferator activated receptor-gamma coactivator-1alpha.	Hydrogen	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	104-135
31468277-8	2020	Enzyme-linked immunosorbent assay performed on day 7 revealed that hydrogen water reduced the level of the pro-inflammatory cytokine interleukin-6 and increased that of forkhead box P3 transcription factor, suggesting an enhancement of regulatory T cell activity.	Hydrogen	67-75	forkhead box P3	Mus musculus	169-184
17763374-5	2007	Docking analysis indicated that the binding to D(2) and 5-HT(1A) receptors is based on (i) interaction between protonated N1 of the piperazine ring and various aspartate residues, (ii) hydrogen bonds between various moieties of the ligand and the residues of threonine, serine, histidine or tryptophane, and (iii) edge-to-face interactions of the aromatic ring of the arylpiperazine moiety with phenylalanine or tyrosine residues.	Hydrogen	185-193	5-hydroxytryptamine receptor 1A	Homo sapiens	56-63
31650545-10	2020	Ursolic acid interacted with alpha-amylase and alpha-glucosidase mainly through hydrogen bonding.	Hydrogen	80-88	sucrase isomaltase (alpha-glucosidase)	Mus musculus	47-64
17693144-1	2007	Binding of the Cdc25c-T48 ligand to PinA from Aspergillus nidulans has been characterised by the identification of 15N and 1H resonances from 1H-15N HSQC NMR titration experiments using previous backbone assignments.	Hydrogen	123-125	cell division cycle 25C	Homo sapiens	15-21
17693144-1	2007	Binding of the Cdc25c-T48 ligand to PinA from Aspergillus nidulans has been characterised by the identification of 15N and 1H resonances from 1H-15N HSQC NMR titration experiments using previous backbone assignments.	Hydrogen	142-144	cell division cycle 25C	Homo sapiens	15-21
17693144-5	2007	The effect of substitution of R17 by N17 in Pin1 has been investigated via a computational study, which predicted that changing R17 to N17 in Pin1 lowers the ligand binding affinity as a result of reduced hydrogen bonding between the protein and the phosphate group of the ligand.	Hydrogen	205-213	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	44-48
17693144-5	2007	The effect of substitution of R17 by N17 in Pin1 has been investigated via a computational study, which predicted that changing R17 to N17 in Pin1 lowers the ligand binding affinity as a result of reduced hydrogen bonding between the protein and the phosphate group of the ligand.	Hydrogen	205-213	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	142-146
31654544-5	2020	This unique structure makes Pt 1 /def-TiO 2 exhibit a recorded-level photocatalytic hydrogen production performance with an unexpectedly high turnover frequency of 51423 h -1 , exceeding the Pt nanoparticles supported TiO 2 catalyst by a factor of 591.	Hydrogen	84-92	zinc finger protein 77	Homo sapiens	28-32
17691815-6	2007	Our results also reveal that the secondary structural stability of the c-Cbl RING domain is mainly determined by the hydrogen-bonding networks in or near the two zinc ion binding sites.	Hydrogen	117-125	Cbl proto-oncogene	Homo sapiens	71-76
31924176-0	2020	Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	54-59
31924176-9	2020	Hydrogen pretreatment upregulated ROS and the expression of pyroptosis-related proteins, and increased the number of PI- and TUNEL-positive cells, as well as the release of LDH and IL-1beta, however, GSDMD depletion reduced their release.	Hydrogen	0-8	interleukin 1 alpha	Mus musculus	181-189
17764303-1	2007	By incorporating effective basis sets containing diffuse functions only in the interaction region of hydrogen-bonded complexes into the simple extrapolation scheme suitable for such basis sets, an accurate estimation of the MP2 basis set limit hydrogen-bonding energies of formic acid tetramer, formamide tetramer, alanine-water, phenol-water, and guanine-cytosine base pair is made with all estimates falling within 0.1-0.3 kcalmol of the reference basis set limits.	Hydrogen	101-109	tryptase pseudogene 1	Homo sapiens	224-227
17764303-1	2007	By incorporating effective basis sets containing diffuse functions only in the interaction region of hydrogen-bonded complexes into the simple extrapolation scheme suitable for such basis sets, an accurate estimation of the MP2 basis set limit hydrogen-bonding energies of formic acid tetramer, formamide tetramer, alanine-water, phenol-water, and guanine-cytosine base pair is made with all estimates falling within 0.1-0.3 kcalmol of the reference basis set limits.	Hydrogen	244-252	tryptase pseudogene 1	Homo sapiens	224-227
31924176-13	2020	CONCLUSIONS: This study extended our original analysis of the ability of hydrogen to stimulate NLRP3 inflammasome/GSDMD activation in pyroptosis and revealed possible mechanism (s) for improvement of anti-tumor effects in the clinical management of endometrial cancer.	Hydrogen	73-81	NLR family, pyrin domain containing 3	Mus musculus	95-100
31936088-5	2020	Endo and exo isomers were distinguished in 1H NMR, and the transition from a kinetic, controlled Diels-Alder reaction to a thermodynamic one could be observed in the temperature range studied.	Hydrogen	43-45	mannosidase endo-alpha	Homo sapiens	0-4
17649987-0	2007	Assessment of the MP2 method, along with several basis sets, for the computation of interaction energies of biologically relevant hydrogen bonded and dispersion bound complexes.	Hydrogen	130-138	tryptase pseudogene 1	Homo sapiens	18-21
31793609-1	2019	A general and simple metal-free protocol for expedient C-H functionalization leading to the regioselective generation of C-5 chalcogenated 8-aminoquinoline analogues in up to 90% yield at room temperature (25  C) has been established.	Hydrogen	55-58	complement C5	Homo sapiens	121-124
17658879-3	2007	A conventional interpretation of these band shifts would suggest that the CCl2 fragment of DCCl3 is a stronger hydrogen-bond acceptor than the BF2 fragment of a BF4- group.	Hydrogen	111-119	C-C motif chemokine ligand 2	Homo sapiens	74-78
31765133-11	2019	The intramolecular activation of a phenyl C-H bond to yield ortho-metalated complexes has a barrier of 13.4 kcal/mol, and the intermolecular oxidative addition of solvent molecule C6H6 to form (eta5-C5Me5)Ir(PPh3)(Ph)H has a barrier of 15.9 kcal/mol.	Hydrogen	35-45	protein phosphatase 4 catalytic subunit	Homo sapiens	208-212
17585849-1	2007	A dilute solution of water in a hydrophobic solvent, such as carbon tetrachloride (CCl4), presents an opportunity to study the rotational properties of water without the complicating effects of hydrogen bonds.	Hydrogen	194-202	C-C motif chemokine ligand 4	Homo sapiens	83-87
17550293-2	2007	The potential energy surfaces of HS- and HSe- with 1,2-diselenirane, 1,2-diselenetane, 1,2-diselenolane, and 1,2-diselenane were computed at B3LYP/6-31+G(d) and MP2/6-31+G(d).	Hydrogen	33-35	tryptase pseudogene 1	Homo sapiens	161-169
19636830-0	2007	1H, 13C and 15N resonance assignment of phage T4 endoribonuclease RegB.	Hydrogen	0-2	site-specific RNA endonuclease	Escherichia phage T4	66-70
31891044-4	2019	Co2TiAl and Ni2TiAl alloys exhibited relatively high H2 production rates because of the formation of fine particles via the selective oxidation of Ti.	Hydrogen	53-55	complement C2	Homo sapiens	0-3
31529537-5	2019	DFT calculations and MD simulations revealed a very stable hydrogen bond between the 3"-hydroxyl and uracil N1H profoundly restricts flexibility and positioning of each ribityl hydroxyl, potentially impacting their interactions with MR1 and TCR.	Hydrogen	59-67	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	241-244
17524381-18	2007	The L(alpha)/NL phase transition temperatures are also higher in the rac-beta-D-GalDAGs than in the corresponding rac-beta-D-GlcDAGs, suggesting that the orientation of the hydroxyl at position 4 and the chirality of the glycerol molecule in the lipid/water interface influence both the L(c) and NL phase properties of these lipids, probably by controlling the relative positions of hydrogen bond donors and acceptors in the polar region of the membrane.	Hydrogen	383-391	AKT serine/threonine kinase 2	Homo sapiens	69-77
17936255-2	2007	The alpha1-helical sequences that are shared by class I RT1.A(l) and RT1.A(u) were substituted in the RT1.A(a) molecule to produce the composite [alpha(1h)(l/u)]-RT1.A(a) MHC class I allochimeric molecule.	Hydrogen	152-154	adrenoceptor alpha 1D	Homo sapiens	4-10
17497842-4	2007	We found that incorporating unsaturated hydrocarbon substituents and polar, hydrogen-bond-accepting groups were beneficial for rTAAR1 and mTAAR1, respectively, providing compounds that were equipotent or more potent than 1.	Hydrogen	76-84	trace-amine-associated receptor 1	Rattus norvegicus	127-133
31689578-0	2019	Functionalization of GlucoPyranosides at position 5 by 1,5 C-H insertion of Rh(II)-Carbenes: Dramatic influence of the anomeric configuration.	Hydrogen	59-62	Rh blood group D antigen	Homo sapiens	76-82
17497776-2	2007	chi3 measurements of amido acid functionalized fused quartz/water interfaces are consistent with two acid-base equilibria, suggesting the formation of a laterally hydrogen-bonded environment similar to what is observed for aliphatic carboxylic acids.	Hydrogen	163-171	chitinase 1	Homo sapiens	0-4
17497810-1	2007	The self-assembly of a Wilkinson type of catalyst molecule, trans-RhCl(CO)(PPh3)2, on Au(111) surfaces and its electrocatalytic properties toward the hydrogen evolution reaction (HER) are investigated by employing scanning tunneling microscopy (STM), cyclic voltammetry (CV), and X-ray photoelectron spectroscopy (XPS).	Hydrogen	150-158	protein phosphatase 4 catalytic subunit	Homo sapiens	75-79
31689578-2	2019	The development of this transformation furthermore reveals that insertion of Rh(II)-carbenes into the C5-H bond is controlled by remote stereoelectronic effects induced by the axial or equatorial orientation of the aglycone.	Hydrogen	102-106	Rh blood group D antigen	Homo sapiens	77-83
31754117-0	2019	An efficient and stable photoelectrochemical system with 9% solar-to-hydrogen conversion efficiency via InGaP/GaAs double junction.	Hydrogen	69-77	regenerating family member 3 alpha	Homo sapiens	104-109
17523804-7	2007	The performance of harmonic B3LYP and MP2 calculations in predicting hydrogen-bond-induced spectral shifts and couplings is investigated.	Hydrogen	69-77	tryptase pseudogene 1	Homo sapiens	38-41
32051770-3	2019	Here, we examined dihydrofolate reductase (DHFR), an enzyme that catalyzes hydride from C4" of NADPH to C6 of 7,8-dihydrofolate (H2F).	Hydrogen	129-132	dihydrofolate reductase	Homo sapiens	43-47
31491412-10	2019	Molecular docking studies revealed that LASSBio-294 and LASSBio-897 interact with active sites of the eNOS (endothelial nitric oxide synthase) enzymes through hydrogen bonds.	Hydrogen	159-167	nitric oxide synthase 3, endothelial cell	Mus musculus	108-141
17432829-7	2007	The results of our investigations provide structural explanations for the ability of hNeil1 to excise a variety of oxidative lesions: they possess common chemical features, namely, a pyrimidine-like ring and shared hydrogen bond donor-acceptor properties, which allow the lesions to fit well in the binding pocket, which is somewhat flexible.	Hydrogen	215-223	nei like DNA glycosylase 1	Homo sapiens	85-91
31608342-7	2019	Furthermore, due to the specificity of the MEK5/ERK5 protein structure, the binding sites and binding patterns of BCA and MEK5 were analyzed using molecular docking correlation techniques, which showed that there are stable hydrogen bonds between BCA and the PB1 domain of MEK5 as well as its kinase domain.	Hydrogen	224-232	mitogen-activated protein kinase 7	Homo sapiens	48-52
17274015-0	2007	A PM3/d specific reaction parameterization for iron atom in the hydrogen abstraction catalyzed by soybean lipoxygenase-1.	Hydrogen	64-72	maturation protein PM3	Glycine max	2-5
31376766-6	2019	The hydrogen generation rate on ZMCN, the best photocatalyst among MCN, DCN, UCN, ZDCN and ZUCN, was around 2.5 times higher than the pristine MCN.	Hydrogen	4-12	urocortin	Homo sapiens	77-80
17274015-1	2007	This paper reports a specific reaction parameter (SRP) PM3/d model for iron that can reproduce the DFT/MM results of the hydrogen abstraction reaction from the C11 position of linoleic acid by the Soybean lipoxygenase-1 enzyme.	Hydrogen	121-129	maturation protein PM3	Glycine max	55-58
23815761-9	2014	The stabilizing hydrogen bonds (H-bonds) between phosphate groups and Trp1, Lys3, and Arg15 of the peptides played important roles for membrane anchoring.	Hydrogen	16-24	tRNA-Pro (anticodon AGG) 2-5	Homo sapiens	70-74
31522365-1	2019	Inspired by the bioinorganic structure of natural [FeFe]-hydrogenase ([FeFe]-H2ase) that possesses iron sulfur clusters to catalyze proton reduction to hydrogen (H2), we design a supramolecular photosystem by sequentially integrating hydrophobic ruthenium complex (as a photosensitizer) and diiron dithiolate complex (as a photocatalyst) into the inner surface or cavity of apoferritin via noncovalent interactions.	Hydrogen	57-65	ferritin heavy chain 1	Homo sapiens	374-385
17259282-10	2007	The network of hydrogen bonds observed in the loop between alpha1 and alpha2 is consequently reorganized.	Hydrogen	15-23	adrenoceptor alpha 1D	Homo sapiens	59-76
17384232-2	2007	In this study, the mechanism by which TF allosterically activates FVIIa is investigated by a structural dynamics approach that combines molecular dynamics (MD) simulations and hydrogen/deuterium exchange (HX) mass spectrometry on free and TF-bound FVIIa.	Hydrogen	176-184	coagulation factor III, tissue factor	Homo sapiens	38-40
31646326-10	2019	AFB1-increased phosphorylation levels of ERK, JNK and p38 MAPK in liver tissue were down-regulated significantly by hydrogen-enriched water treatment.	Hydrogen	116-124	mitogen-activated protein kinase 8	Rattus norvegicus	46-49
17300195-2	2007	In the context of the HoxD9 homeodomain bound specifically to DNA we were able to directly observe three cross-peaks, arising from lysine NH3 groups, with 15N chemical shifts around approximately 33 ppm at pH 5.8 and 35 degrees C. Measurement of water-exchange rates and various types of 15N transverse relaxation rates for these NH3 groups, reveals that rapid water exchange dominates the 15N relaxation for antiphase coherence with respect to 1H through scalar relaxation of the second kind.	Hydrogen	445-447	homeobox D9	Homo sapiens	22-27
31550138-2	2019	For example, the critical nitrenoid intermediates that mediate Rh2-catalyzed C-H amination have eluded characterization for more than 40 years.	Hydrogen	77-80	Rh associated glycoprotein	Homo sapiens	63-66
17286402-8	2007	DFT calculations on C5H5 model metallocenes show that the reaction of Cp2CeH with CO and H2 to give Cp2CeOMe is exoergic by 50 kcal mol-1.	Hydrogen	89-91	ceruloplasmin	Homo sapiens	70-73
17286402-9	2007	The net reaction proceeds by a series of elementary reactions that occur after the formyl complex, Cp2Ce(eta2-CHO), is formed by further reaction with H2.	Hydrogen	151-153	ceruloplasmin	Homo sapiens	99-102
31351380-6	2019	More intriguingly, molecular docking simulation suggested that all compounds bind into the active site of alpha-glucosidase by multiple van-der-Waals and hydrogen bond interactions.	Hydrogen	154-162	sucrase-isomaltase	Homo sapiens	106-123
31318308-5	2019	Crystal structures (PDB accession codes 6MXR, 6MXS, 6MY4, 6MY5) and bottom-up hydrogen-exchange mass spectrometry revealed that Fab self-association occurs in a symmetric mode that involves the antigen complementarity-determining regions.	Hydrogen	78-86	FA complementation group B	Homo sapiens	128-131
17207813-3	2007	As there are no structural data for Tip, hydrogen-exchange mass spectrometry was used to investigate the conformation of a nearly full-length form (residues 1-187) of Tip from HVS strain C484.	Hydrogen	41-49	TOR signaling pathway regulator	Homo sapiens	167-170
17207813-7	2007	Hydrogen-exchange mass spectrometry of Tip then showed that the majority of backbone amide hydrogen atoms became deuterated after only 10 s of labeling.	Hydrogen	0-8	TOR signaling pathway regulator	Homo sapiens	39-42
17207813-7	2007	Hydrogen-exchange mass spectrometry of Tip then showed that the majority of backbone amide hydrogen atoms became deuterated after only 10 s of labeling.	Hydrogen	91-99	TOR signaling pathway regulator	Homo sapiens	39-42
17263404-4	2007	The neutral complexes form cyclic hydrogen bonds, and the most stable dimers are bound by 17.7 and 16.0 kcal/mol for AFA and MAFA, respectively.	Hydrogen	34-42	MAF bZIP transcription factor A	Homo sapiens	125-129
31515451-8	2019	PI(4,5)P2 is stabilized by hydrogen bonding between amino acid side chains and phosphate/hydroxyl groups on PI(4,5)P2 Binding of PI(4,5)P2 alters the position of the cytoplasmic extension of TM6, which plays a crucial role in ANO1 channel gating, and increases the accessibility of the inner vestibule to Cl- ions.	Hydrogen	27-35	anoctamin 1	Homo sapiens	226-230
17228922-0	2007	Hydrogen-bonded nucleic acid base pairs containing unusual base tautomers: complete basis set calculations at the MP2 and CCSD(T) levels.	Hydrogen	0-8	tryptase pseudogene 1	Homo sapiens	114-117
31464312-4	2019	A crystal growth model involving assembly and coalescence was developed to describe the crystal growth and the corresponding PL properties, where hydroxyl-motivated hydrogen-bonding interaction was used to explain the oriented assembly of CdS QDs.	Hydrogen	165-173	CDP-diacylglycerol synthase 1	Homo sapiens	239-242
17070843-3	2007	Here we extend this study to cover the entire interface of TEM1 beta-lactamase and its protein inhibitor BLIP using an improved method for deriving interaction maps based on REDUCE to add hydrogen atoms and then by evaluating the interactions using modifications of the programs PROBE, NCI and PARE.	Hydrogen	188-196	CD248 molecule	Homo sapiens	59-63
31271801-8	2019	Docking simulations showed binding affinities of compounds 1 to 5 for hMAO-B were higher than those for hMAO-A or AChE and suggested these five chalcones form hydrogen bonds with MAO-B at Cys172 but that they do not form hydrogen bonds with hMAO-A or AChE.	Hydrogen	159-167	monoamine oxidase A	Homo sapiens	104-110
31483550-5	2019	Results from obtained data showed that H2 S decreased the expression of SRA, Grp78, PERK, CHOP and Caspase-3, and increased that of LC3-II/LC3-I, in addition to alleviating the pathological changes of liver and reducing the levels of ALT, AST, LDH TBARS and MDA.	Hydrogen	39-41	DNA-damage inducible transcript 3	Rattus norvegicus	90-94
17685003-5	2007	RESULTS: The activity of hydrogen producing enzymes D-aminoacid oxidase, Urate oxidase and Palmitoyl CoA oxidase was statistically significantly increased in the treated group in comparison with the control one.	Hydrogen	25-33	urate oxidase	Rattus norvegicus	73-86
31291611-7	2019	Molecular docking indicated potential interactions of demethylbellidifolin (1) with HCE 2 through two hydrogen bonds of the C-3 and C-5 hydroxy groups with amino acid residues Glu227 and Ser228 in the catalytic cavity, respectively.	Hydrogen	102-110	complement C5	Homo sapiens	132-135
17685003-5	2007	RESULTS: The activity of hydrogen producing enzymes D-aminoacid oxidase, Urate oxidase and Palmitoyl CoA oxidase was statistically significantly increased in the treated group in comparison with the control one.	Hydrogen	25-33	acyl-CoA oxidase 1	Rattus norvegicus	91-112
17661322-6	2007	These were predicted to undergo intramolecular hydrogen-atom transfer to form [VO(OH)2(eta1-OCHR)]- followed by eta1-O--&gt;eta2-C,O rearrangements to form [VO(OH)2(eta2-OCHR)]-.	Hydrogen	47-55	secreted phosphoprotein 1	Homo sapiens	87-91
17492819-0	2007	Low-temperature adsorption/storage of hydrogen on FAU, MFI, and MOR zeolites with various Si/Al ratios: effect of electrostatic fields and pore structures.	Hydrogen	38-46	opioid receptor mu 1	Homo sapiens	64-67
31200337-10	2019	Hydrogen gas inhalation significantly alleviated OVA-induced airway hyperresponsiveness, inflammation and goblet cell hyperplasia, diminished TH2 response and decreased IL-4 as well as IgE levels, reduced malondialdehyde (MDA) production and increased superoxide dismutase (SOD) activity.	Hydrogen	0-8	heart and neural crest derivatives expressed 2	Mus musculus	142-145
17143275-0	2007	HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.	Hydrogen	19-27	major histocompatibility complex, class II, DM alpha	Homo sapiens	0-6
17143275-6	2007	We suggest that DM may mediate peptide dissociation by a "hit-and-run" mechanism that results in conformational changes in MHC class II molecules and disruption of hydrogen bonds between betaHis81 and bound peptide.	Hydrogen	164-172	major histocompatibility complex, class II, DM alpha	Homo sapiens	16-18
31200337-10	2019	Hydrogen gas inhalation significantly alleviated OVA-induced airway hyperresponsiveness, inflammation and goblet cell hyperplasia, diminished TH2 response and decreased IL-4 as well as IgE levels, reduced malondialdehyde (MDA) production and increased superoxide dismutase (SOD) activity.	Hydrogen	0-8	interleukin 4	Mus musculus	169-173
31381293-2	2019	Herein, we selected two hydrogen-bonded and pi-pi interactions-supported ferrocenyl carboxylate frameworks (FCFs), [FcCO(CH2)2COOH] (FCF 1) and [FcCOOH] (FCF 2) (Fc = (eta5-C5H5)Fe(eta5-C5H4)) to fully investigate their water-mediated proton conduction.	Hydrogen	24-32	FCF1 rRNA-processing protein	Homo sapiens	133-138
17008107-5	2007	Our data show that the phosphorylation of STAT5 was increased in hippocampal CA1 at 1h and 3h ischemia.	Hydrogen	84-86	carbonic anhydrase 1	Rattus norvegicus	77-80
31304746-6	2019	Herein, we report the development of GO and niobium-doped titanium dioxide nanotube (NT) hybrid structures with a tunable selectivity and sensing response against hydrogen gas, achieved by properly controlling the degree of reduction and concentration of GO.	Hydrogen	163-171	gastrin	Homo sapiens	172-175
18058552-0	2007	Structural insight into the hTERT intron 6 sequence d(GGGGTGAAAGGGG) from 1H-NMR study.	Hydrogen	74-76	telomerase reverse transcriptase	Homo sapiens	28-33
31304946-5	2019	Uncontaminated MSc(BH4)4 salts decompose thermally yielding nearly pure hydrogen with the maximum decomposition rate at 230  C and 235  C, for M = Rb and Cs, respectively.	Hydrogen	72-80	musculin	Homo sapiens	15-24
31315971-0	2019	Frontal lobe 1H MR spectroscopy in asymptomatic and symptomatic MAPT mutation carriers.	Hydrogen	13-15	microtubule associated protein tau	Homo sapiens	64-68
17052728-5	2006	The adenine moiety of the substrates is specifically recognized by the enzyme via hydrogen-bonding interactions between N1 and N6 of the base and Glu47 of one subunit, and between N7 of the base and Arg51 of the other subunit, providing the molecular basis for the high selectivity of hNUDT5 for ADP-sugars over other sugar nucleotides.	Hydrogen	82-90	nudix hydrolase 5	Homo sapiens	285-291
19810406-7	2006	Irrespective of the method used, the hydrogen bond donor radius increases in the order HF &lt; HCl &lt; H2O &lt; HBr &lt; HCN &lt; HCCH &lt; H2S, but mostly lie between Pauling"s covalent and van der Waals radii of H atom.	Hydrogen	37-45	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	122-125
25214720-0	2014	Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	30-35
31315971-1	2019	OBJECTIVE: To determine the frontal lobe proton magnetic resonance spectroscopy (1H MRS) abnormalities in asymptomatic and symptomatic carriers of microtubule-associated protein tau (MAPT) mutations.	Hydrogen	81-83	microtubule associated protein tau	Homo sapiens	147-181
31315971-1	2019	OBJECTIVE: To determine the frontal lobe proton magnetic resonance spectroscopy (1H MRS) abnormalities in asymptomatic and symptomatic carriers of microtubule-associated protein tau (MAPT) mutations.	Hydrogen	81-83	microtubule associated protein tau	Homo sapiens	183-187
24177879-3	2014	Hydrogen-bonded dimer of HBT, optimized by counterpoise correction, was studied by MP2 and DFT/B3LYP at the 6-311+G(d,p) level and the effects of molecular association through NH---O hydrogen bonding were discussed.	Hydrogen	0-8	tryptase pseudogene 1	Homo sapiens	83-86
24215616-9	2013	Furthermore, when [Ir(H)2(pyridine-h5)(pyridine-d5)(IMes)(PPh3)]BF4 is examined, its hydride ligand signals are shown to become visible through para-hydrogen-induced polarization rather than SABRE.	Hydrogen	149-157	protein phosphatase 4 catalytic subunit	Homo sapiens	58-62
23899557-3	2013	Rotenone exposure (100nM, 1h) triggered the translocation of m53-EGFP from the mitochondrion to the nucleus, thus shifting the transfected cells from a mitochondrial p53 to a nuclear p53 state.	Hydrogen	26-28	transformation related protein 53, pseudogene	Mus musculus	166-169
23899557-3	2013	Rotenone exposure (100nM, 1h) triggered the translocation of m53-EGFP from the mitochondrion to the nucleus, thus shifting the transfected cells from a mitochondrial p53 to a nuclear p53 state.	Hydrogen	26-28	transformation related protein 53, pseudogene	Mus musculus	183-186
24148008-1	2013	The microwave (4-20 GHz range) and infrared (HCl and DCl stretch ranges) spectra of six isotopic species of the CH3Cl-HCl hydrogen bond complex have been recorded for the first time and analyzed with the support of high level ab initio calculations (MP2 and CCSD(T) levels).	Hydrogen	122-130	tryptase pseudogene 1	Homo sapiens	250-253
24190998-5	2013	Hydrogen-deuterium exchange mass spectrometry shows that association with the p101 regulatory subunit causes substantial protection of the RBD-C2 linker as well as the helical domain of p110gamma.	Hydrogen	0-8	phosphoinositide-3-kinase regulatory subunit 5	Homo sapiens	78-82
24190998-5	2013	Hydrogen-deuterium exchange mass spectrometry shows that association with the p101 regulatory subunit causes substantial protection of the RBD-C2 linker as well as the helical domain of p110gamma.	Hydrogen	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	186-195
24273532-11	2013	Chimeras of RXFP1 with the LDLa of RXFP2 demonstrated reduced H2 relaxin potency with the pairing of the RXFP2 TM with the RXFP2 LDLa necessary for full ligand efficacy.	Hydrogen	62-64	relaxin family peptide receptor 1	Homo sapiens	12-17
24273532-11	2013	Chimeras of RXFP1 with the LDLa of RXFP2 demonstrated reduced H2 relaxin potency with the pairing of the RXFP2 TM with the RXFP2 LDLa necessary for full ligand efficacy.	Hydrogen	62-64	relaxin family peptide receptor 2	Homo sapiens	35-40
24085300-7	2013	Based on the crystal structures of the p25 (p35 C-terminal region including AD)-Cdk5 complex, we simulated the three-dimensional structure of the p39 AD-Cdk5 complex and found differences in the hydrogen bond network between Cdk5 and its activators.	Hydrogen	195-203	cyclin dependent kinase 5	Homo sapiens	80-84
24085300-7	2013	Based on the crystal structures of the p25 (p35 C-terminal region including AD)-Cdk5 complex, we simulated the three-dimensional structure of the p39 AD-Cdk5 complex and found differences in the hydrogen bond network between Cdk5 and its activators.	Hydrogen	195-203	cyclin dependent kinase 5	Homo sapiens	153-157
24085300-7	2013	Based on the crystal structures of the p25 (p35 C-terminal region including AD)-Cdk5 complex, we simulated the three-dimensional structure of the p39 AD-Cdk5 complex and found differences in the hydrogen bond network between Cdk5 and its activators.	Hydrogen	195-203	cyclin dependent kinase 5	Homo sapiens	153-157
24085300-8	2013	Three amino acids of p35, Asp-259, Asn-266, and Ser-270, which are involved in hydrogen bond formation with Cdk5, are changed to Gln, Gln, and Pro in p39.	Hydrogen	79-87	cyclin dependent kinase 5	Homo sapiens	108-112
24085300-9	2013	Because these three amino acids in p39 do not participate in hydrogen bond formation, we predicted that the number of hydrogen bonds between p39 and Cdk5 was reduced compared with p35 and Cdk5.	Hydrogen	118-126	cyclin dependent kinase 5	Homo sapiens	149-153
24085300-10	2013	Using substitution mutants, we experimentally validated that the difference in the hydrogen bond network contributes to the different properties between Cdk5 and its activators.	Hydrogen	83-91	cyclin dependent kinase 5	Homo sapiens	153-157
24257230-7	2013	RESULTS: We found that hydrogen-rich saline significantly elevated the mechanical thresholds of neuropathic pain compared to vehicle (physiologic saline) control in CCI rats (p&lt;0.05); it also decreased the levels of myeloperoxidase, maleic dialdehyde, and protein carbonyl in spinal cord by 7 days post-chronic constriction injury(p&lt;0.05).	Hydrogen	23-31	myeloperoxidase	Rattus norvegicus	219-234
23848594-8	2013	The Asn198 is located in the amphipathic cavity comprising Leu869(IN), Glu868(IN), Thr872(IN), Tyr197(AurA) and Tyr199(AurA) and the interactions mediated via hydrogen bonds are important to stabilize the Aurora-A(G198N) - INCENP complex.	Hydrogen	159-167	inner centromere protein	Homo sapiens	223-229
24029921-0	2013	Synthesis of ultrathin CdS nanosheets as efficient visible-light-driven water splitting photocatalysts for hydrogen evolution.	Hydrogen	107-115	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
24029921-2	2013	The as-obtained CdS ultrathin nanosheets exhibit efficient photocatalytic activity and good stability for hydrogen production.	Hydrogen	106-114	CDP-diacylglycerol synthase 1	Homo sapiens	16-19
24030544-0	2013	Efficient photocatalytic hydrogen production in water using a cobalt(III) tetraaza-macrocyclic catalyst: electrochemical generation of the low-valent Co(I) species and its reactivity toward proton reduction.	Hydrogen	25-33	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	150-155
24020881-0	2013	Effect of hydrogen bond formation on the NMR properties of glycine-HCN complexes.	Hydrogen	10-18	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	67-70
24020881-3	2013	Six different conformations of hydrogen-bonded clusters have considered for both 1:1 and 1:2 glycine-HCN complexes.	Hydrogen	31-39	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	101-104
23904258-9	2013	The conformational change of mutant laforin was confirmed by analysis using root mean square deviation, root mean square fluctuation, solvent accessibility surface area, radius of gyration, hydrogen bond, and principle component analysis.	Hydrogen	190-198	EPM2A glucan phosphatase, laforin	Homo sapiens	36-43
23001946-0	2013	1H, 13C and 15N assignments of Sgt2 N-terminal dimerisation domain and its binding partner, Get5 Ubiquitin-like domain.	Hydrogen	0-2	small glutamine rich tetratricopeptide repeat co-chaperone beta	Homo sapiens	31-35
23132527-0	2013	1H, 13C and 15N resonance assignments of the N-terminal domain of Vta1-Vps60 peptide complex.	Hydrogen	0-2	vesicle trafficking 1	Homo sapiens	66-70
23179058-0	2013	1H, 13C, and 15N backbone and side chain resonance assignments of the C-terminal DNA binding and dimerization domain of v-Myc.	Hydrogen	0-2	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	122-125
24070285-7	2013	The largest differences between CCSD(T) and MP2 are observed for the harmonic hydrogen bonded frequencies, for which the former produces larger absolute values than the latter.	Hydrogen	78-86	tryptase pseudogene 1	Homo sapiens	44-47
24070285-8	2013	Their CCSD(T) redshifts from the monomer values (Deltaomega) are smaller than the MP2 ones, due to the fact that CCSD(T) produces shorter elongations (DeltaR) of the respective hydrogen bonded OH lengths from the monomer value with respect to MP2.	Hydrogen	177-185	tryptase pseudogene 1	Homo sapiens	82-85
24070285-8	2013	Their CCSD(T) redshifts from the monomer values (Deltaomega) are smaller than the MP2 ones, due to the fact that CCSD(T) produces shorter elongations (DeltaR) of the respective hydrogen bonded OH lengths from the monomer value with respect to MP2.	Hydrogen	177-185	tryptase pseudogene 1	Homo sapiens	243-246
24070285-9	2013	Both the MP2 and CCSD(T) results for the hydrogen bonded frequencies were found to closely follow the relation -Deltaomega = s   DeltaR, with a rate of s = 20.2 cm(-1)/0.001 A for hydrogen bonded frequencies with IR intensities &gt;400 km/mol.	Hydrogen	41-49	tryptase pseudogene 1	Homo sapiens	9-12
24070285-9	2013	Both the MP2 and CCSD(T) results for the hydrogen bonded frequencies were found to closely follow the relation -Deltaomega = s   DeltaR, with a rate of s = 20.2 cm(-1)/0.001 A for hydrogen bonded frequencies with IR intensities &gt;400 km/mol.	Hydrogen	180-188	tryptase pseudogene 1	Homo sapiens	9-12
23855811-0	2013	The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528).	Hydrogen	18-26	cannabinoid receptor 2	Homo sapiens	110-113
23747483-4	2013	Here, we use hydrogen exchange in conjunction with mass spectrometry to study the dynamics of the human Notch3 NRR in four distinct biochemical states: in its unmodified quiescent form, in a proteolytically "on" state induced by ethylenediaminetetraacetic acid, and in complex with either agonist or inhibitory antibodies.	Hydrogen	13-21	notch receptor 3	Homo sapiens	104-110
23945020-7	2013	In contrast, under bulk electrolysis conditions, H2 formation requires only one reducing equivalent per [HCo(III)(L2)(CH3CN)](2+), indicating a bimetallic route wherein two cobalt hydride complexes react to form 2 equiv of [Co(I)(L2)(CH3CN)](+) and 1 equiv of H2.	Hydrogen	49-51	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	224-229
23846855-2	2013	Three-dimensional (3D) molecular docking demonstrates the strong hydrogen bonding and hydrophobic interactions of MC with amino acids of aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) within 4 A and subsequent inhibition of cAMP response element-binding protein (CREB), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors.	Hydrogen	65-73	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	173-219
17125375-1	2006	A highly efficient photocatalytic system for hydrogen evolution with dihydronicotinamide coenzyme (NADH) as a sacrificial agent in an aqueous solution has been constructed by using water-soluble platinum clusters functionalized with methyl viologen-alkanethiol (MVA2+) and a simple electron-donor dyad, 9-mesityl-10-methylacridinium ion (Acr+-Mes), which is capable of fast photoinduced electron transfer but extremely slow back electron transfer.	Hydrogen	45-53	acrosin	Homo sapiens	338-341
17017773-7	2006	The formally unsaturated species 1 and [1H]BArF4 have strongly contrasting Lewis acidities, with the cation binding PPh3, CO, and NH3.	Hydrogen	40-42	protein phosphatase 4 catalytic subunit	Homo sapiens	116-120
17268673-1	2006	The combination of hexamethyldisilane and a catalytic amount of [PdCl(eta3-C3H5)]2-PPh3 was found to be effective for the trimethylsilylation of alcohols, where both of the two trimethylsilyl groups of hexamethyldisilane were transferred to alcohols without coproduction of any stoichiometric amount of byproduct but H2.	Hydrogen	317-319	protein phosphatase 4 catalytic subunit	Homo sapiens	83-87
16963788-2	2006	Analyses with various spectroscopic methods including MALDI-TOF-MS indicated that two axial His residues (His44 and His68) of cytochrome b(5) were protected from the modification by several factors, i.e., limited steric exposure of the axial imidazole to the solvent, the Fe-N(epsilon2) coordination bond, and protonation of the N(delta1) position by forming a hydrogen bond with its immediate surroundings.	Hydrogen	361-369	cytochrome b5 type A	Homo sapiens	126-141
16970460-1	2006	The hydrogen/deuterium exchange reaction of 2,2-dimethylpropane (neopentane) over D(2)O-exchanged zeolites (MOR, FAU, BEA, MFI) using a batch recirculation reactor was studied by means of gas chromatography coupled with mass spectrometer.	Hydrogen	4-12	opioid receptor mu 1	Homo sapiens	108-111
16964984-1	2006	Hydrogen exchange monitored by mass spectrometry (HX-MS), in conjunction with multiple optical probes, has been used to characterize the unfolding of thioredoxin.	Hydrogen	0-8	thioredoxin	Homo sapiens	150-161
17168540-7	2006	The structures show that these compounds bind to the Smac-binding site on ML-IAP with identical hydrogen-bonding patterns and similar hydrophobic interactions.	Hydrogen	96-104	diablo IAP-binding mitochondrial protein	Homo sapiens	53-57
16884224-3	2006	The addition of LiTf and NaTf to DMEDA shifts the N-H stretching frequencies through two competing effects: the cation coordination effect lowers the frequencies, while the disruption of the hydrogen-bonding interactions increases the frequencies.	Hydrogen	191-199	zinc finger protein 644	Homo sapiens	25-29
16495028-2	2006	The PCA of the 1H NMR spectra of the aqueous fractions allowed a clear discrimination between antler samples according to their origins by the first three principal components (PC1, PC2, and PC3), which cumulatively accounted for 93.5% of the variation in all variables.	Hydrogen	15-17	proprotein convertase subtilisin/kexin type 1	Homo sapiens	177-180
16495028-2	2006	The PCA of the 1H NMR spectra of the aqueous fractions allowed a clear discrimination between antler samples according to their origins by the first three principal components (PC1, PC2, and PC3), which cumulatively accounted for 93.5% of the variation in all variables.	Hydrogen	15-17	chromobox 4	Homo sapiens	182-185
16495028-2	2006	The PCA of the 1H NMR spectra of the aqueous fractions allowed a clear discrimination between antler samples according to their origins by the first three principal components (PC1, PC2, and PC3), which cumulatively accounted for 93.5% of the variation in all variables.	Hydrogen	15-17	proprotein convertase subtilisin/kexin type 1	Homo sapiens	191-194
16565516-3	2006	Titration of p23 with Hsp90 results in the selective broadening of certain cross-peaks in the 15N-1H heteronuclear single quantum correlation (HSQC) spectrum.	Hydrogen	98-100	prostaglandin E synthase 3	Homo sapiens	13-16
16565516-3	2006	Titration of p23 with Hsp90 results in the selective broadening of certain cross-peaks in the 15N-1H heteronuclear single quantum correlation (HSQC) spectrum.	Hydrogen	98-100	heat shock protein 90 alpha family class A member 1	Homo sapiens	22-27
16534823-9	2006	Hydrogen bonding among the components of the catalytic reaction was examined by MP2 calculations on model compounds.	Hydrogen	0-8	tryptase pseudogene 1	Homo sapiens	80-83
16602793-2	2006	ArP(O)(OH)2 forms an interesting hydrogen-bonded corrugated sheet-type supramolecular structure in the solid-state.	Hydrogen	33-41	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	0-3
16599513-2	2006	By using low-temperature scanning tunneling microscopy, tip-induced motion of adsorbed atomic hydrogen at 4 K has been observed at low coverage.	Hydrogen	94-102	TOR signaling pathway regulator	Homo sapiens	56-59
16599513-4	2006	At higher coverages, tip-induced motion of vacancies in the hydrogen overlayer is observed, and the associated barrier has also been determined.	Hydrogen	60-68	TOR signaling pathway regulator	Homo sapiens	21-24
16570991-4	2006	For the H2O-CCl4 interface, though, there was a compensation between these strong hydrogen bonds and short to moderate ranged repulsion between iodide and CCl4.	Hydrogen	82-90	C-C motif chemokine ligand 4	Homo sapiens	12-16
16436281-2	2006	To gain insight into the structural features associated with the activated form of Itk, we have solved the NMR structure of the SH2 domain bound to a phosphotyrosine-containing peptide (pY) and analyzed changes in trans-hydrogen bond scalar couplings ((3h)J(NC")) that result from pY binding.	Hydrogen	220-228	IL2 inducible T cell kinase	Homo sapiens	83-86
16526755-2	2006	The geometrical difference between m- and p-Pm-PCl2 in solution was confirmed by 1H NMR on the basis of the porphyrin ring current model.	Hydrogen	81-83	metal response element binding transcription factor 2	Homo sapiens	47-51
16526765-1	2006	G3(MP2) and other model chemistry calculations indicate that stabilization energies of extensively conjugated allylic radicals H2(C=C)nCH2*, n = 1-4, increase monotonically as the number of repeating C=C units increase.	Hydrogen	127-129	tryptase pseudogene 1	Homo sapiens	3-6
16477668-1	2006	The properties of six dihydrogen-bonded (DHB) dimers with the BeH2 molecule as a proton acceptor were calculated by MP2, CCSD(T) and B3LYP methods.	Hydrogen	22-32	tryptase pseudogene 1	Homo sapiens	116-119
16494969-6	2006	Docking of 2-[[-5-bromo-2-oxoindolin-3-ylidene]amino]-3-(1H-imidazol2-yl)propanoic acid 14 to CDK5/p25 indicates that this compound can interact with the enzyme through four hydrogen bonds; for GSK/3beta, the ligand poses itself in another orientation, also four hydrogen bonds can be formed between the ligand and the receptor, otherwise hydrophobic interactions seem to predominate.	Hydrogen	174-182	cyclin dependent kinase 5	Homo sapiens	94-98
16494969-6	2006	Docking of 2-[[-5-bromo-2-oxoindolin-3-ylidene]amino]-3-(1H-imidazol2-yl)propanoic acid 14 to CDK5/p25 indicates that this compound can interact with the enzyme through four hydrogen bonds; for GSK/3beta, the ligand poses itself in another orientation, also four hydrogen bonds can be formed between the ligand and the receptor, otherwise hydrophobic interactions seem to predominate.	Hydrogen	263-271	cyclin dependent kinase 5	Homo sapiens	94-98
16493051-4	2006	Testing of three models for Stat3 Src homology 2-pY ligand binding in vitro and in vivo revealed unique determinants for Stat3 recruitment and activation by the G-CSFR, the side chain of Stat3 R609, which interacts with the pY ligand phosphate group, and the peptide amide hydrogen of E638, which bonds with oxygen/sulfur within the + 3 Q/C side chain of the pY ligand when it assumes a beta turn.	Hydrogen	273-281	colony stimulating factor 3 receptor	Homo sapiens	161-167
16452621-3	2006	We noticed a dramatic difference in dilute solution 1H-15N Heteronuclear Single Quantum Coherence (HSQC) spectra of wild-type alpha-synuclein and two disease-related mutants (A30P and A53T), with spectra collected at 35 degrees C showing fewer cross-peaks than spectra acquired at 10 degrees C. Here, we show the change to be the result of a reversible conformational exchange linked to an increase in hydrodynamic radius and secondary structure as the temperature is raised.	Hydrogen	52-54	synuclein alpha	Homo sapiens	126-141
16241906-0	2006	Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase.	Hydrogen	32-40	Dihydrofolate reductase	Escherichia coli	87-110
16241906-10	2006	The mechanism by which hydrogen tunnelling in DHFR is coupled with the environment appears therefore to be sensitive to pH.	Hydrogen	23-31	Dihydrofolate reductase	Escherichia coli	46-50
16239221-8	2005	Together, these changes represent the first documented pre-symptomatic symptoms of the Cln3 mouse at 1 month of age and demonstrate the versatility of 1H NMR spectroscopy as a tool for phenotyping mouse models of disease.	Hydrogen	151-153	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	Mus musculus	87-91
16366623-6	2005	The complexes have an L-shaped structure with a hydrogen bond between the oxygen atom of ketene and the hydrogen atom of HCN or HNC.	Hydrogen	48-56	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	121-124
16366623-6	2005	The complexes have an L-shaped structure with a hydrogen bond between the oxygen atom of ketene and the hydrogen atom of HCN or HNC.	Hydrogen	104-112	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	121-124
16366642-0	2005	B3LYP and MP2 calculations of the enthalpies of hydrogen-bonded complexes of methanol with neutral bases and anions: comparison with experimental data.	Hydrogen	48-56	tryptase pseudogene 1	Homo sapiens	10-13
16366642-6	2005	Of the methods considered, only MP2/aug-cc-pVTZ calculations are capable of reproducing the binding enthalpy within the experimental error for the first-row acceptor atoms N, O, and F, and of accounting for dispersion effects created by alkylation at the hydrogen-bond acceptor site.	Hydrogen	255-263	tryptase pseudogene 1	Homo sapiens	32-35
16854005-2	2005	The hydrogen bonding of cocaine with the oxyanion hole of BChE is found to be remarkably different from that of ACh with AChE/BChE.	Hydrogen	4-12	butyrylcholinesterase	Homo sapiens	58-62
16854005-2	2005	The hydrogen bonding of cocaine with the oxyanion hole of BChE is found to be remarkably different from that of ACh with AChE/BChE.	Hydrogen	4-12	butyrylcholinesterase	Homo sapiens	126-130
16854005-3	2005	Whereas G121/G116, G122/G117, and A204/A199 of AChE/BChE all can form hydrogen bonds with ACh to stabilize the transition state during the ACh hydrolysis, BChE only uses G117 and A199 to form hydrogen bonds with cocaine.	Hydrogen	70-78	butyrylcholinesterase	Homo sapiens	52-56
16854005-3	2005	Whereas G121/G116, G122/G117, and A204/A199 of AChE/BChE all can form hydrogen bonds with ACh to stabilize the transition state during the ACh hydrolysis, BChE only uses G117 and A199 to form hydrogen bonds with cocaine.	Hydrogen	70-78	butyrylcholinesterase	Homo sapiens	155-159
16854005-3	2005	Whereas G121/G116, G122/G117, and A204/A199 of AChE/BChE all can form hydrogen bonds with ACh to stabilize the transition state during the ACh hydrolysis, BChE only uses G117 and A199 to form hydrogen bonds with cocaine.	Hydrogen	192-200	butyrylcholinesterase	Homo sapiens	52-56
16854005-3	2005	Whereas G121/G116, G122/G117, and A204/A199 of AChE/BChE all can form hydrogen bonds with ACh to stabilize the transition state during the ACh hydrolysis, BChE only uses G117 and A199 to form hydrogen bonds with cocaine.	Hydrogen	192-200	butyrylcholinesterase	Homo sapiens	155-159
16246573-4	2005	Two other carbanions CH(2)CN(-) and CH(2)S(O)CH(3)(-) also undergo the novel hydrogen/chlorine exchange reactions with CCl(4) but to a much smaller extent, their higher nucleophilicities favoring competitive nucleophilic attack reactions.	Hydrogen	77-85	C-C motif chemokine ligand 4	Homo sapiens	119-125
16242719-7	2005	In contrast, both dimers and trimers, formed by reduced beta2m, are comprised of parallel beta-sheets between monomers and stabilized by the hydrogen bond network along the backbone.	Hydrogen	141-149	beta-2-microglobulin	Homo sapiens	56-62
16269753-5	2005	Additional experiments revealed that the level of tceA expression was independent of the concentration of chlorinated ethenes (sum concentrations of TCE and DCEs of 2.2 to 333 microM), the concentration of the electron donor hydrogen (concentrations of 12 nM to 17 microM), and the presence of alternate bacterial electron acceptors (5 mM concentrations of fumarate, sulfate, sulfite, thiosulfate, nitrate, or nitrite) but was highly dependent on incubation temperature.	Hydrogen	225-233	transcription elongation factor A1	Homo sapiens	50-54
16331426-0	2005	1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complex.	Hydrogen	0-2	LIM domain binding 1	Homo sapiens	54-58
16099164-5	2005	Ion 1+ is calculated to undergo fast migrations of protons among positions N-1, C-2, N-3, N-10, N-7, and C-8 that result in an exchange of five hydrogens before loss of a hydrogen atom forming adenine cation radical at 415 kJ mol(-1) dissociation threshold energy.	Hydrogen	144-153	complement C2	Homo sapiens	80-83
16099164-5	2005	Ion 1+ is calculated to undergo fast migrations of protons among positions N-1, C-2, N-3, N-10, N-7, and C-8 that result in an exchange of five hydrogens before loss of a hydrogen atom forming adenine cation radical at 415 kJ mol(-1) dissociation threshold energy.	Hydrogen	144-152	complement C2	Homo sapiens	80-83
16217837-3	2005	For the ATP and FMN aptamers, where ligand interactions involve both hydrogen bonding and significant pi-stacking, the relative binding affinities determined by MS did not fully correlate with results obtained from solution experiments.	Hydrogen	69-77	formin 1	Homo sapiens	16-19
16195463-3	2005	Instead, the template G is evicted from the DNA helix, and it makes optimal hydrogen bonds with a segment of Rev1.	Hydrogen	76-84	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	109-113
16834216-5	2005	The hydrogen bond energy of the complexes varies from 2.95 to 4.22 kcal/mol and is stronger than our previously studied bromocyclopropane-ammonia complex (2.35 kcal/mol, MP2).	Hydrogen	4-12	tryptase pseudogene 1	Homo sapiens	170-173
16248399-14	2005	There are only a few reports concerning 1H-MRS findings in patients with PML and the present case illustrates the difficulty of making a differential diagnosis between PML and glioma.	Hydrogen	40-42	PML nuclear body scaffold	Homo sapiens	73-76
16248399-14	2005	There are only a few reports concerning 1H-MRS findings in patients with PML and the present case illustrates the difficulty of making a differential diagnosis between PML and glioma.	Hydrogen	40-42	PML nuclear body scaffold	Homo sapiens	168-171
16099456-4	2005	Additionally, flr mutant cells revealed a decrease of about 50% in the H2 consumption rate using thiosulfate as electron acceptor.	Hydrogen	71-73	biliverdin reductase B	Homo sapiens	14-17
31315971-10	2019	CONCLUSION: Frontal lobe neurochemical alterations measured with 1H MRS precede the symptom onset in MAPT mutation carriers.	Hydrogen	65-67	microtubule associated protein tau	Homo sapiens	101-105
31315971-11	2019	Frontal lobe 1H MRS is a potential biomarker for early neurodegenerative processes in MAPT mutation carriers.	Hydrogen	13-15	microtubule associated protein tau	Homo sapiens	86-90
31406233-3	2019	TMC and PEG-HA were synthesized, characterized (1H-NMR and FTIR), and added to the formulations to enhance drug release from the hydrogels, and increase the drug targeting of the carriers.	Hydrogen	48-50	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	0-3
31344959-3	2019	Molecular docking simulations clarified that the hydroxyl residues of the isolated compounds formed hydrogen bonds with residues at the catalytic and allosteric sites of tyrosinase, while other residues participated in hydrophobic interactions.	Hydrogen	100-108	tyrosinase	Mus musculus	170-180
31087519-5	2019	Moreover, the H2 generation enabled by the Co-MoS2 cocatalyst can exhibit universality in alkalescent electrolytes, such as triethanolamine (TEA) and disodium ethylenediaminetetraacetic acid (EDTA), exhibiting greater photocatalytic H2 generation than Pt/CdS.	Hydrogen	14-16	CDP-diacylglycerol synthase 1	Homo sapiens	255-258
31087519-6	2019	The design of Co-MoS2 /CdS sheds light on the development of highly efficient low-cost photocatalysts for solar H2 generation from water reduction.	Hydrogen	112-114	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
31029021-5	2019	The experiments including Job"s plot, UV-Vis titration, 1H NMR titration and ESI-MS spectrum established that the probe CTB binds to Cd2+ in a 1:2 ratio.	Hydrogen	56-58	chitobiase	Homo sapiens	120-123
31029021-5	2019	The experiments including Job"s plot, UV-Vis titration, 1H NMR titration and ESI-MS spectrum established that the probe CTB binds to Cd2+ in a 1:2 ratio.	Hydrogen	56-58	CD2 molecule	Homo sapiens	133-136
31083022-15	2019	The number of osteoclasts and size of resorption pits of RANKL+H2-treated cells were 3 to 4 times less than RANKL treated cells.	Hydrogen	63-65	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	57-62
31083022-16	2019	The expression of osteoclast marker genes of RANKL+H2-treated cells was 30% to 60% lower than RANKL-treated cells (P &lt; 0.05).	Hydrogen	51-53	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	45-50
31083022-17	2019	H2 markedly inhibited RANKL-induced activation, nuclear translocation, and transcriptional activity of NF-kappaB (P &lt; 0.05, RANKL+H2 vs RANKL).	Hydrogen	0-2	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	22-27
31083022-17	2019	H2 markedly inhibited RANKL-induced activation, nuclear translocation, and transcriptional activity of NF-kappaB (P &lt; 0.05, RANKL+H2 vs RANKL).	Hydrogen	0-2	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	127-132
31083022-17	2019	H2 markedly inhibited RANKL-induced activation, nuclear translocation, and transcriptional activity of NF-kappaB (P &lt; 0.05, RANKL+H2 vs RANKL).	Hydrogen	0-2	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	127-132
31083022-17	2019	H2 markedly inhibited RANKL-induced activation, nuclear translocation, and transcriptional activity of NF-kappaB (P &lt; 0.05, RANKL+H2 vs RANKL).	Hydrogen	133-135	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	22-27
31245003-13	2019	H2 diet up-regulated the expression of ZO-1 compared with control group (P &lt; 0.05).	Hydrogen	0-2	zonula occludens 1	Sus scrofa	39-43
30921659-5	2019	Then, the response mechanism of TCF-Cys for Cys was revealed by TLC, 1H NMR, HPLC, HRMS and DFT calculation.	Hydrogen	69-71	ETS transcription factor ELK4	Danio rerio	32-35
23680234-4	2013	The TACs/Sep method significantly decreased the time required for NK cell isolation (1h vs. 4h), but resulted in higher red blood cell contamination.	Hydrogen	85-87	plexin B1	Homo sapiens	9-12
31042074-0	2019	Hydrogen-rich saline ameliorated LPS-induced acute lung injury via autophagy inhibition through the ROS/AMPK/mTOR pathway in mice.	Hydrogen	0-8	mechanistic target of rapamycin kinase	Mus musculus	109-113
23982207-5	2013	Nuclear magnetic resonance and hydrogen-deuterium exchange mass spectrometry analyses revealed that Itk and Btk had distinct protein dynamics in this region, which could explain the differences in catalytic efficiency between these kinases.	Hydrogen	31-39	IL2 inducible T cell kinase	Homo sapiens	100-103
31099353-5	2019	Moreover, transportation behaviour indicated that these molecules could efficiently bind to and be carried by bovine albumin, and the hydrogen bonding and hydrophobic interactions played important roles in interaction with serum albumin.	Hydrogen	134-142	albumin	Bos taurus	117-124
31099353-5	2019	Moreover, transportation behaviour indicated that these molecules could efficiently bind to and be carried by bovine albumin, and the hydrogen bonding and hydrophobic interactions played important roles in interaction with serum albumin.	Hydrogen	134-142	albumin	Bos taurus	223-236
31137573-6	2019	Conclusions: The pharmacophore model consisting of a hydrogen bond donor, hydrophobic points and a positive ionizable point may be helpful for designing small-molecule inhibitors targeting PD-L1.	Hydrogen	53-61	CD274 molecule	Homo sapiens	189-194
30706621-6	2019	Finally, Pd2+ reduction toward Pd0 pathways were explored computationally either by generated H2 or reductive elimination of CO2 and H2 gas.	Hydrogen	94-96	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	9-12
30706621-6	2019	Finally, Pd2+ reduction toward Pd0 pathways were explored computationally either by generated H2 or reductive elimination of CO2 and H2 gas.	Hydrogen	133-135	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	9-12
31050439-0	2019	Sterically Hindered 2,4,6-Tri- tert-butylpyridinium Salts as Single Hydrogen Bond Donors for Highly Stereoselective Glycosylation Reactions of Glycals.	Hydrogen	68-76	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	26-29
31096936-0	2019	Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-alpha expression.	Hydrogen	22-30	vascular endothelial growth factor A	Rattus norvegicus	98-108
16089455-5	2005	The outside attachment of two hydrogen atoms to two adjacent carbon atoms located between two six-membered rings of the C60 cage affects the orientation of the LiF molecule inside and increases the stability of LiF inside the cage by 45%.	Hydrogen	30-38	LIF interleukin 6 family cytokine	Homo sapiens	160-163
31096936-14	2019	CONCLUSIONS: Our findings demonstrate that inhalation of hydrogen gas could alleviate retinal oedema, shorten reopen time and improve retinal function, and the potential mechanism might be related to a decrease in VEGF-alpha expression.	Hydrogen	57-65	vascular endothelial growth factor A	Rattus norvegicus	214-224
16089455-5	2005	The outside attachment of two hydrogen atoms to two adjacent carbon atoms located between two six-membered rings of the C60 cage affects the orientation of the LiF molecule inside and increases the stability of LiF inside the cage by 45%.	Hydrogen	30-38	LIF interleukin 6 family cytokine	Homo sapiens	211-214
16089455-6	2005	In contrast, when 60 hydrogen atoms were attached to the outside surface of the C60 cage, thus transforming all C=C double bonds into single bonds, the stability of the LiF inside was reduced by 34%.	Hydrogen	21-29	LIF interleukin 6 family cytokine	Homo sapiens	169-172
30860308-2	2019	DFT calculations revealed that the preferred reaction mechanism involves the unsaturated 16-e mangana-substituted phosphonium ylide complex fac-[Mn(CO)3 (kappa2 P,C-Ph2 P=CHNHC)] (6 b) as key intermediate able to activate H2 via a non-classical mode of metal-ligand cooperation implying a formal lambda5 -P-lambda3 -P phosphorus valence change.	Hydrogen	222-224	immunoglobulin lambda like polypeptide 1	Homo sapiens	296-303
31012458-1	2019	The facet-dependent strain effects on the hydrogen evolution reaction catalyzed by CoP were studied using density functional theory methods.	Hydrogen	42-50	caspase recruitment domain family member 16	Homo sapiens	83-86
15937899-7	2005	To study the structural coupling between internal waters and buried polar atoms in detail we simulated the dynamics of wild-type FKBP12, in which a buried water, Wat137, forms one side-chain and multiple main-chain hydrogen bonds.	Hydrogen	215-223	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	129-135
16120190-6	2005	The molecular modelling studies of human CYP1A2 used the crystal structure of rabbit CYP2C5 as a template based on protein sequence homology and an interactive docking procedure using a dynamic hydrogen bond feature.	Hydrogen	194-202	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	41-47
31021087-6	2019	Computational studies suggest a molecular mechanism for the observed synergy effects, which originate at (1) the different roles of Ni1 and Ru1 sites in terms of activations of CH4 to form CO on a Ni1 site and dissociation of CO2 to CO on a Ru1 site, respectively and (2) the sequential role in terms of first forming H atoms through activation of CH4 on a Ni1 site and then coupling of H atoms to form H2 on a Ru1 site.	Hydrogen	403-405	Scm like with four mbt domains 1	Homo sapiens	140-143
16833952-1	2005	An ab initio computational study of the properties of four linear dihydrogen-bonded complexes formed between the first compound with an Ar-C chemical bond (FArCCH) and HBeX (X = H, F, Cl, and Br) molecules was undertaken at the MP2/6-311++G(2d,2p) level of theory.	Hydrogen	66-76	tryptase pseudogene 1	Homo sapiens	228-231
31087870-7	2019	After 48h, the hydrogen production rate of CA-H, CA-M, CA-L was 21.45, 28.60, and 22.75 times higher than CK.	Hydrogen	15-23	filamin binding LIM protein 1	Homo sapiens	55-59
15884917-2	2005	This intermediate leads to three parallel transformations of cyclohexene, namely (a) C-H activation of cyclohexene to form an eta3-cyclohexenyl hydrido complex, (b) combination of cyclohexene and H2 to form a cyclohexyl hydrido complex, and (c) coupling of two molecules of cyclohexene with concomitant loss of two hydrogen atoms to form a complex containing a novel eta1,eta3-(cyclohexyl)cyclohexenyl ligand.	Hydrogen	196-198	secreted phosphoprotein 1	Homo sapiens	367-371
15884917-2	2005	This intermediate leads to three parallel transformations of cyclohexene, namely (a) C-H activation of cyclohexene to form an eta3-cyclohexenyl hydrido complex, (b) combination of cyclohexene and H2 to form a cyclohexyl hydrido complex, and (c) coupling of two molecules of cyclohexene with concomitant loss of two hydrogen atoms to form a complex containing a novel eta1,eta3-(cyclohexyl)cyclohexenyl ligand.	Hydrogen	315-323	secreted phosphoprotein 1	Homo sapiens	367-371
30833107-5	2019	Our molecular modelling studies revealed that the double bond in 2g provided the best fit in the binding site of KLK5, while the hydrogen bonding interactions modulated the best fit of 2c in the binding site of KLK7 due to the hydrophobicity of the cavity.	Hydrogen	129-137	kallikrein related peptidase 7	Homo sapiens	211-215
15833597-11	2005	The present data demonstrate that both HS and IMO are powerful stimuli for the majority of hypothalamic structures displaying considerable topographic similarity in Fos expression suggesting their multifunctional involvement.	Hydrogen	39-41	FBJ osteosarcoma oncogene	Mus musculus	165-168
30649746-1	2019	Plecanatide, a uroguanylin analog, activates the guanylate cyclase C receptors in the epithelial lining of the gastrointestinal tract in a pH-dependent fashion initiating (1) the conversion of intracellular guanosine triphosphate to cyclic guanosine monophosphate, which increases the activity of the cystic fibrosis transmembrane conductance regulator to increase chloride and bicarbonate secretion into the intestinal lumen and (2) a decrease in activity of the sodium-hydrogen ion exchanger.	Hydrogen	471-479	natriuretic peptide receptor 3	Homo sapiens	49-68
19787898-7	2005	The calculated harmonic force constants for the intermolecular hydrogen bond stretching vibration upsilon(sigma) for the ground state and the excited HCl libration state indicate that the excitation of the HCl libration mode destabilizes the intermolecular interaction between HCN and HCl by almost 20%.	Hydrogen	63-71	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	277-280
31028486-4	2019	AIM analysis at the MP2/aug-cc-pVTZ-pp level of theory indicates that the (NH)carbene XH hydrogen bonds are generally stronger than the Au   HX interactions, except for those involving HF.	Hydrogen	89-97	tryptase pseudogene 1	Homo sapiens	20-23
15881576-1	2005	Twenty two hydrogen-bonded and improper blue-shifting hydrogen-bonded complexes were studied by means of the HF, MP2 and B3LYP methods using the 6-31G(d,p) and 6--311 ++G(d,p) basis sets.	Hydrogen	54-62	tryptase pseudogene 1	Homo sapiens	113-116
30990480-0	2019	The shape-controlled synthesis of gallium-palladium (GaPd2) nanomaterials as high-performance electrocatalysts for the hydrogen evolution reaction.	Hydrogen	119-127	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Homo sapiens	53-58
16097692-4	2005	This spectral feature reveals that H3L2+ gradually lost hydrogen ion combined on C-4 keto oxygen.	Hydrogen	56-64	complement C4A (Rodgers blood group)	Homo sapiens	81-84
30901203-8	2019	The catalytic activity for hydrogen evolution ordered by higher current at a fixed electrode geometric area and low onset potential is CoP3 &gt; NiP2 (cubic and monoclinic) &gt; FeP2 &gt;&gt; CuP2.	Hydrogen	27-35	BCL2 interacting protein 2	Homo sapiens	145-149
15766269-4	2005	Using amide hydrogen/deuterium exchange monitored by mass spectrometry, we show that DeltaK58-beta(2)m has increased unfolding rates compared to wt-beta(2)m and that unfolding is highly temperature dependent.	Hydrogen	12-20	beta-2-microglobulin	Homo sapiens	94-102
15727869-5	2005	The structure-activity relationships of these naphthols analyzed by docking experiments, indicated that the presence of hydroxyl group at C-1 position on the naphthalene nucleus enhanced the anti-inflammatory activity towards COX-2 via hydrogen bonding to the COX-2 Val 523 side chain.	Hydrogen	236-244	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	138-141
15727869-8	2005	All active compounds have the C-1 hydroxyl group aligned so as to form hydrogen bond with Val 523.	Hydrogen	71-79	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	30-33
15730274-2	2005	Both 1H NMR spectroscopic and voltammetric experiments clearly reveal that Cob+ experiences encapsulation.	Hydrogen	5-7	metabolism of cobalamin associated B	Homo sapiens	75-78
15723532-1	2005	Cooperativity mediated through hydrogen bond networks in yeast iso-1-cytochrome c was studied using a thermodynamic triple mutant cycle.	Hydrogen	31-39	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	63-68
15723532-6	2005	Previously reported structural data for iso-1-cytochrome c variants containing these mutations show that changes in the strength of the His 26 to Glu 44 hydrogen bond, apparently caused by changes in main chain dynamics, provide a mechanism for the long distance (His 26 to Phe 67 and His 26 to Ile 52) propagation of pairwise interaction energies.	Hydrogen	153-161	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	40-45
15533938-0	2005	Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3" subsite of matrix metalloproteinase 8 (MMP-8): the role of hydrogen bonding potential of ASN188 and TYR189 and the connecting cis bond.	Hydrogen	160-168	matrix metallopeptidase 8	Homo sapiens	112-138
15533938-9	2005	Therefore, S(3)" and in particular the hydrogen bonding potential of Tyr(189) is a specific molecular determinant for MMP-8 triple helicase activity.	Hydrogen	39-47	matrix metallopeptidase 8	Homo sapiens	118-123
15819386-8	2005	Thus, besides the salt bridges and hydrogen bonds, edge-to-face interactions significantly contribute to arylpiperazine ligands to form complexes with the DAR D2.	Hydrogen	35-43	adrenoceptor alpha 1D	Homo sapiens	155-158
15541364-3	2004	Arachidonic acid elevated in situ tTGase activity in dose- and time-dependent manners with a maximal level at 1h, and ROS scavengers, N-(2-mercaptopropionyl)glycine and catalase, blocked the tTGase activation by arachidonic acid.	Hydrogen	110-112	transglutaminase 2, C polypeptide	Mus musculus	34-40
15566299-9	2004	This phenol group, together with a hydrophobic moiety and hydrogen-bonding features, is suggested to form an active SIRT2 pharmacophore.	Hydrogen	58-66	sirtuin 2	Homo sapiens	116-121
23561952-2	2013	The experimental results show that the maximum H2 production performance of 42.1 mL H2/g dry cell weight (dcw) was predicted at 0.79% (v/w) HCl and at a specific energy input (SEI) of 49,600 kJ/kg dcw in the combined pretreatment, while it was limited in both individual pretreatments.	Hydrogen	47-49	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	81-86
23530864-10	2013	Finally, C35 -isoprenoid hydrocarbons were identified as new lipid biomarkers for ANME-1, most likely functioning as a hydrogen sink during methanogenesis.	Hydrogen	119-127	migration and invasion enhancer 1	Homo sapiens	9-12
30916046-1	2019	The synthesis is described of a pH-universal hydrogen evolution electrocatalyst based on N and P co-doped graphitic carbon encapsulated OsP2 (OsP2@NPC) nanoparticles of 1.8 nm size for the electrocatalytic hydrogen evolution reaction (HER).	Hydrogen	206-214	NPC intracellular cholesterol transporter 1	Homo sapiens	142-150
15578744-3	2004	The use of horse cytochrome c as a reference allowed us to make very accurate comparisons of the small differences in hydrogen exchange rates among the various species.	Hydrogen	118-126	cytochrome c, somatic	Equus caballus	17-29
31097989-2	2019	To selectively induce the secretion of certain cytokines via introducing hydrogen-bonding interaction with polar amino acid residues in the binding pocket of CD1d, a series of alpha-GalCer analogues with diether moiety in the acyl chain were designed and synthesized.	Hydrogen	73-81	CD1d molecule	Homo sapiens	158-162
15482939-0	2004	Synthesis of 5"-substituted fluoro-neplanocin A analogues: importance of a hydrogen bonding donor at 5"-position for the inhibitory activity of S-adenosylhomocysteine hydrolase.	Hydrogen	75-83	adenosylhomocysteinase	Homo sapiens	144-176
23718776-5	2013	Notably, His382 inserts into the major groove of DNA, and stabilizes the EGR1-DNA interaction via both hydrogen bonding and van der Waals contacts.	Hydrogen	103-111	early growth response 1	Homo sapiens	73-77
24228592-5	2013	The results of the molecular modeling showed that the main interaction force between CGA and BLF or BSA was hydrogen bonds, together with Van der Waals" forces and hydrophobic effect.	Hydrogen	108-116	albumin	Bos taurus	100-103
30663099-2	2019	The aim of this study was to prepare a new derivative of 1-(2-methoxyphenyl)piperazine (MPP) as a main chemical structure of 5HT1A receptor antagonist with 3-carbon linker and radiolabeled by [99m Tc][Tc(CO)3 (H2 O)3 ]+ precursor.	Hydrogen	210-212	5-hydroxytryptamine receptor 1A	Homo sapiens	125-139
23743286-4	2013	Substitutions with a hydroxy group at both R1 and R3 of the phenyl ring indicated that these groups play a major role in the high binding affinity to tyrosinase, especially through the hydrogen bonding interaction of the hydroxyl group at R1 with GLY281.	Hydrogen	185-193	tyrosinase	Mus musculus	150-160
15498669-7	2004	Structure-activity data acquired indicate that a (Z)-olefin having cis C-1 4-acetoxyphenyl (phenyl) and C-2 4-methylsulfonylphenyl substituents, and a C-1 phenyl substituent in conjunction with either a C-2 hydrogen or short alkyl substituent provides a novel template to design acyclic olefinic COX-2 inhibitors that, like aspirin, have the potential to acetylate COX-2.	Hydrogen	207-215	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	151-154
30718815-2	2019	On the basis of X-ray crystallography, hydrogen-deuterium exchange-mass spectrometry and surface plasmon resonance experiments we propose that the cyclopropylethyl moiety displaces the DFG motif of the enzyme away from the adenosine tri-phosphate binding site, inducing a large conformational change in both the kinase- and helical domains of PI3Kgamma.	Hydrogen	39-47	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	343-352
15453720-2	2004	As in the case of the catalytic substrates of DDH, e.g., ethane-1,2-diol, the 5"-deoxyadenosyl radical (Ado*) is able to abstract a hydrogen atom from both substrate analogues in the initial step on the reaction pathway, as evidenced by comparable energy barriers.	Hydrogen	132-140	aldo-keto reductase family 1 member C1	Homo sapiens	46-49
15453720-4	2004	The barrier for hydrogen atom reabstraction by the glycolaldehyde radical is calculated to be too high ( approximately 110 kJ mol-1) to allow Ado* to be regenerated and recombine with the cob(II)alamin radical, the latter therefore remaining tightly bound to DDH.	Hydrogen	16-24	aldo-keto reductase family 1 member C1	Homo sapiens	259-262
23689510-6	2013	A crystal structure of Gipg013 Fab in complex with the human GIPr extracellular domain (ECD) shows that the antibody binds through a series of hydrogen bonds from the complementarity-determining regions of Gipg013 Fab to the N-terminal alpha-helix of GIPr ECD as well as to residues around its highly conserved glucagon receptor subfamily recognition fold.	Hydrogen	143-151	FA complementation group B	Homo sapiens	31-34
23689510-6	2013	A crystal structure of Gipg013 Fab in complex with the human GIPr extracellular domain (ECD) shows that the antibody binds through a series of hydrogen bonds from the complementarity-determining regions of Gipg013 Fab to the N-terminal alpha-helix of GIPr ECD as well as to residues around its highly conserved glucagon receptor subfamily recognition fold.	Hydrogen	143-151	FA complementation group B	Homo sapiens	214-217
23297114-5	2013	In endothelial cells, H2 S treatment reduces the increase in MCP-1, inter-cellular adhesion molecule-1, vascular cell adhesion molecule-1, and of a disintegrin and metalloproteinase metallopeptidase domain 17 (ADAM17), both at the gene expression and protein levels.	Hydrogen	22-24	C-C motif chemokine ligand 2	Homo sapiens	61-137
15349172-2	2004	When hydrogen is bubbled through 1,2-dichloroethane solutions of 1 or 2, two new species were formed in each case by C-Cl bond activation of the solvent, Ir(H)2Cl(eta1-N-L)(PPh3)2 (L = py, 4; iQ, 5) and IrH(Cl)2(eta1-N-L)(PPh3)2 (L = py, 6; iQ, 7).	Hydrogen	5-13	secreted phosphoprotein 1	Homo sapiens	163-167
15349172-2	2004	When hydrogen is bubbled through 1,2-dichloroethane solutions of 1 or 2, two new species were formed in each case by C-Cl bond activation of the solvent, Ir(H)2Cl(eta1-N-L)(PPh3)2 (L = py, 4; iQ, 5) and IrH(Cl)2(eta1-N-L)(PPh3)2 (L = py, 6; iQ, 7).	Hydrogen	5-13	secreted phosphoprotein 1	Homo sapiens	212-216
30688006-7	2019	Moreover, molecular docking analysis shows that the interaction between the 14-3-3sigma and the Hsp74 is mainly through hydrophobic contacts and a lesser degree ionic interactions and hydrogen bond by different amino acids residues.	Hydrogen	184-192	stratifin	Homo sapiens	76-87
15350128-3	2004	All three resveratrol hydroxyl groups form hydrogen bonds with amino acids from QR2, anchoring a flat resveratrol molecule in parallel with the isoalloxazine ring of FAD.	Hydrogen	43-51	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	80-83
15351992-8	2004	In contrast, SA in combination with HS potentiated heat-induced Hsp70/Hsc70 accumulation in tobacco protoplasts that correlated negatively with apoptosis, illustrated by decreased PS exposure and DNA fragmentation and enhanced mitochondrial membrane potential.	Hydrogen	36-38	heat shock cognate 70 kDa protein 2-like	Nicotiana tabacum	64-69
30836005-1	2019	Synthetic peroxo-bridged high-spin (HS) heme-(mu-eta2:eta1-O22-)-Cu(L) complexes incorporating (as part of the copper ligand) intramolecular hydrogen-bond (H-bond) capabilities and/or steric effects are herein demonstrated to affect the complex"s electronic and geometric structure, notably impacting the spin state.	Hydrogen	141-149	secreted phosphoprotein 1	Homo sapiens	54-58
15352223-0	2004	High-resolution magic angle spinning and 1H magnetic resonance spectroscopy reveal significantly altered neuronal metabolite profiles in CLN1 but not in CLN3.	Hydrogen	41-43	palmitoyl-protein thioesterase 1	Homo sapiens	137-141
23901482-0	2013	Facile decoration of Au nanoparticles on CdS nanorods by polyoxometalate with enhanced photocatalytic activities toward hydrogen evolution.	Hydrogen	120-128	CDP-diacylglycerol synthase 1	Homo sapiens	41-44
30716195-0	2019	CoP-Doped MOF-Based Electrocatalyst for pH-Universal Hydrogen Evolution Reaction.	Hydrogen	53-61	caspase recruitment domain family member 16	Homo sapiens	0-3
23672184-5	2013	The maximum H2 evolution of 8320 mumol h(-1)g(-1) is obtained using nanostructured Cd(0.1)Zn(0.9)S, which is four times higher than that of bulk CdS (2020 mumol h(-1) g(-1)) and the reported nanostructured CdS (5890 mumol h(-1)g(-1)).	Hydrogen	12-14	CDP-diacylglycerol synthase 1	Homo sapiens	145-148
23672184-5	2013	The maximum H2 evolution of 8320 mumol h(-1)g(-1) is obtained using nanostructured Cd(0.1)Zn(0.9)S, which is four times higher than that of bulk CdS (2020 mumol h(-1) g(-1)) and the reported nanostructured CdS (5890 mumol h(-1)g(-1)).	Hydrogen	12-14	CDP-diacylglycerol synthase 1	Homo sapiens	206-209
23485707-1	2013	Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio.	Hydrogen	113-117	aquaporin 5	Homo sapiens	60-64
15212818-10	2004	A 1h exposure to 300 nM TBT followed by a 48 h period in TBT-free media showed similar changes in cytotoxic function and levels of granzyme B and perforin as seen after 24 h in TBT-free media.	Hydrogen	2-4	granzyme B	Homo sapiens	131-141
15279884-4	2004	Molecular dynamics calculations suggested that the peptides bound to the Gb3 mimic by hydrophobic interaction and hydrogen bonding formation, and the cooperative interactions played an important role in the recognition.	Hydrogen	114-122	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	73-76
15243187-0	2004	1H, 13C and 15N backbone resonance assignments of matrilysin (MMP7) complexed with a sulfonamide hydroxamate-type inhibitor.	Hydrogen	0-2	matrix metallopeptidase 7	Homo sapiens	50-60
15243187-0	2004	1H, 13C and 15N backbone resonance assignments of matrilysin (MMP7) complexed with a sulfonamide hydroxamate-type inhibitor.	Hydrogen	0-2	matrix metallopeptidase 7	Homo sapiens	62-66
30716195-3	2019	Density functional theory calculations and experimental results reveal that the electron transfer from CoP to Co-MOF through N-P/N-Co bonds could lead to the optimized adsorption energy of H2 O (DeltaG  H  2 O *   ) and hydrogen (DeltaGH* ), which, together with the unique porous structure of Co-MOF, contributes to the remarkable HER performance with an overpotential of 49 mV at a current density of 10 mA cm-2 in 1 m phosphate buffer solution (PBS, pH 7.0).	Hydrogen	220-228	caspase recruitment domain family member 16	Homo sapiens	103-106
30659094-5	2019	Analysis of the Rab5-PI3Kbeta interaction by hydrogen-deuterium exchange MS identified p110beta peptides that overlap with these helices; no interactions were detected between Rab5 and other regions of p110beta or p85alpha.	Hydrogen	45-53	RAB5A, member RAS oncogene family	Homo sapiens	16-20
15284535-7	2004	Examination of the crystal structure of human CYP2C9 reveals that R335 is located in the turn between the J and J" helices and forms a hydrogen-bonding ion pair with D341 from the J" helix.	Hydrogen	135-143	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	46-52
15123616-6	2004	The BB loop contains a hydrogen bond unique to IL-1RAPL between Thr residues at the 8th and 10th positions.	Hydrogen	23-31	interleukin 1 receptor accessory protein like 1	Homo sapiens	47-55
23676025-5	2013	We also consider the hydrogen transfer reactions between several free radicals, for which MP2 provides poor reaction energies.	Hydrogen	21-29	tryptase pseudogene 1	Homo sapiens	90-93
23676025-7	2013	Overall, the OMP2 method seems quite helpful for electronically challenging chemical systems such as symmetry-breaking molecules, hydrogen transfer reactions, or other cases where standard MP2 proves unreliable.	Hydrogen	130-138	tryptase pseudogene 1	Homo sapiens	14-17
23850671-5	2013	Concentration of IL-6 and hepcidin increased 1h after exercise in both groups (p&lt;0.05).	Hydrogen	45-47	hepcidin antimicrobial peptide	Homo sapiens	26-34
30640044-8	2019	Two major degradation products (DP2 and DP3) were isolated using preparative HPLC and their structures were confirmed by conducting 1H and 13C NMR experiments.	Hydrogen	132-134	transcription factor Dp-2	Homo sapiens	32-35
23480293-6	2013	C-2 methylated hopanoids and tetrahymanol account for as much as 59% of the respective C-2 methylated/non-methylated homologs during growth with Fe(II) as electron donor, as compared with 24% C-2 methylation for growth with H2 .	Hydrogen	224-226	complement C2	Homo sapiens	0-3
15250733-1	2004	[H2Ir(OCMe2)2L2]BF4 (1) (L = PPh3), a preferred catalyst for tritiation of pharmaceuticals, reacts with model substrate 2-(dimethylamino)pyridine (py-NMe2; py = 2-pyridyl) to give chelate carbene [H2Ir(py-N(Me)CH=)L2]BF4 (2a) via cyclometalation, H2 loss, and reversible alpha-elimination.	Hydrogen	1-3	protein phosphatase 4 catalytic subunit	Homo sapiens	29-33
15250733-1	2004	[H2Ir(OCMe2)2L2]BF4 (1) (L = PPh3), a preferred catalyst for tritiation of pharmaceuticals, reacts with model substrate 2-(dimethylamino)pyridine (py-NMe2; py = 2-pyridyl) to give chelate carbene [H2Ir(py-N(Me)CH=)L2]BF4 (2a) via cyclometalation, H2 loss, and reversible alpha-elimination.	Hydrogen	1-3	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	150-154
15250733-4	2004	2a rapidly reacts with excess H2 in d6-acetone to generate [H2Ir(OC(CD3)2)2L2]BF4 (1-d12), 3a((CD3)2CO), and py-NMe2 in a 1:1:1 ratio, showing reversibility and accounting for the selective isotope exchange catalyzed by 1.	Hydrogen	30-32	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	112-116
15252583-3	2004	Reaction between HL1 and labile Pt(II) and Pd(II) chlorides formed MCl2(HL1)2 complexes 4 (M = Pt) and 5 (M = Pd) in which a weak N-H...pi(aryl) hydrogen bonding interaction was identified in the solid-state structure of 4.	Hydrogen	145-153	intelectin 1	Homo sapiens	17-20
23514118-6	2013	The NH group of Gly, which as hydrogen bond donor competes with the NH group of Cys4 for the carbonyl oxygen atom of Cys1 as hydrogen bond acceptor, plays a relevant role for the structure and spectroscopic properties of the peptide.	Hydrogen	30-38	cystin 1	Homo sapiens	117-121
30843559-0	2019	CoSe2/CdS-diethylenetriamine coupled with P clusters for efficient photocatalytic hydrogen evolution.	Hydrogen	82-90	CDP-diacylglycerol synthase 1	Homo sapiens	6-9
15338437-1	2004	We observed by SANS and NMR the structure of intermolecular complexes formed through hydrogen bonding and hydrophobic interactions between a polyacid and a neutral copolymer surfactant (PEO-PPO-PEO).	Hydrogen	85-93	USH1 protein network component sans	Homo sapiens	15-19
30889918-5	2019	The highly potent DHFR inhibitors shared a similar molecular docking mode and made a critical hydrogen bond and arene-arene interactions via Ser59 and Phe31 amino acid residues, respectively.	Hydrogen	94-102	dihydrofolate reductase	Homo sapiens	18-22
15268106-3	2004	We find that fluorine substituted aromatic rings are more ordered than unsubstituted aromatic rings by a factor of two based on the polarization dependence of the lowest C 1s to pi* transition, which is associated with transitions from phenyl carbons attached to hydrogens.	Hydrogen	263-272	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	170-173
23514118-6	2013	The NH group of Gly, which as hydrogen bond donor competes with the NH group of Cys4 for the carbonyl oxygen atom of Cys1 as hydrogen bond acceptor, plays a relevant role for the structure and spectroscopic properties of the peptide.	Hydrogen	125-133	cystin 1	Homo sapiens	117-121
30529552-6	2019	EGCG quenched the fluorescence of alpha-glucosidase due to the complex formation between EGCG and alpha-glucosidase, where the hydrogen bonds played a critical role.	Hydrogen	127-135	sucrase-isomaltase	Homo sapiens	34-51
23123249-5	2013	An in vivo testing paradigm was developed in which the novel oxime was administered at the time of maximal brain AChE inhibition (about 80%) (1h) elicited by nitrophenyl isopropyl methylphosphonate (NIMP; sarin surrogate).	Hydrogen	142-144	acetylcholinesterase	Rattus norvegicus	113-117
15189865-5	2004	Energy calculations using the Empirical Conformation Energy Program for Peptides (ECEPP)/2 force field and the implicit solvent model show that the middle of the peptide helix accommodates a bifurcated hydrogen bond that is simultaneously formed between HN Aib(12) and CO Leu(8) and CO Aib(9).	Hydrogen	202-210	selectin L	Homo sapiens	272-278
15189865-8	2004	NMR parameters ((1)HN chemical shifts and transpeptide bond (1)J(NC") couplings) sensitive to hydrogen bonding along with the solvent accessible surface area of carbonyl oxygens indicate a large polar patch on the convex side of the helix formed by three exposed backbone carbonyls of Aib(7), Aib(9), and Hyp(10) and polar side chains of Hyp(10), Gln(11), and Hyp(13).	Hydrogen	94-102	HYP10	Homo sapiens	305-312
15189865-8	2004	NMR parameters ((1)HN chemical shifts and transpeptide bond (1)J(NC") couplings) sensitive to hydrogen bonding along with the solvent accessible surface area of carbonyl oxygens indicate a large polar patch on the convex side of the helix formed by three exposed backbone carbonyls of Aib(7), Aib(9), and Hyp(10) and polar side chains of Hyp(10), Gln(11), and Hyp(13).	Hydrogen	94-102	HYP10	Homo sapiens	338-345
15252635-8	2004	The 1H and 13C NMR spectra of the ligands are consistent with formation of a predominant Zn2+ and Cd2+ Delta or Lambda diastereomer.	Hydrogen	4-6	CD2 molecule	Homo sapiens	98-101
15252636-3	2004	Complex 1 shows dynamic NMR behaviour in both the 31P and 1H NMR spectra with facile exchange between the protons in the eta2-dihydrogen ligand and the eta1-hydrido ligand.	Hydrogen	58-60	secreted phosphoprotein 1	Homo sapiens	152-156
23437875-0	2013	Stable hydrogen evolution from CdS-modified CuGaSe2 photoelectrode under visible-light irradiation.	Hydrogen	7-15	CDP-diacylglycerol synthase 1	Homo sapiens	31-34
30529552-6	2019	EGCG quenched the fluorescence of alpha-glucosidase due to the complex formation between EGCG and alpha-glucosidase, where the hydrogen bonds played a critical role.	Hydrogen	127-135	sucrase-isomaltase	Homo sapiens	98-115
23437875-4	2013	CdS-deposited CuGaSe2 showed high stability under the observed reaction conditions and evolved hydrogen continuously for more than 10 days.	Hydrogen	95-103	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
30785285-8	2019	The molecular docking of resveratroloside with alpha-glucosidase demostrated the competitive inhibitory effect of resveratroloside, which occupies the catalytic site and forms strong hydrogen bonds with the residues of alpha-glucosidase.	Hydrogen	183-191	sucrase isomaltase (alpha-glucosidase)	Mus musculus	47-64
15115773-0	2004	Mass spectrometry of hydrogen/deuterium exchange of Escherichia coli dihydrofolate reductase: effects of loop mutations.	Hydrogen	21-29	Dihydrofolate reductase	Escherichia coli	69-92
15267387-2	2004	The binding energies of the first and second hydrogen molecule to the gold clusters were determined using density functional theory (DFT), second order perturbation theory (MP2) and coupled cluster (CCSD(T)) methods.	Hydrogen	45-53	tryptase pseudogene 1	Homo sapiens	173-176
30785285-8	2019	The molecular docking of resveratroloside with alpha-glucosidase demostrated the competitive inhibitory effect of resveratroloside, which occupies the catalytic site and forms strong hydrogen bonds with the residues of alpha-glucosidase.	Hydrogen	183-191	sucrase isomaltase (alpha-glucosidase)	Mus musculus	219-236
23065758-6	2013	We demonstrate the capabilities of this approach by performing illustrative studies of large proteins--namely, investigating changes in charge transfer between the heme group of myoglobin and its ligands with increasing system size and between a protein and its explicit solvent, estimating the contribution of electronic delocalization to the stabilization of hydrogen bonds in the binding pocket of a drug-receptor complex, and observing, in situ, the n   pi* hyperconjugative interactions between carbonyl groups that stabilize protein backbones.	Hydrogen	361-369	myoglobin	Homo sapiens	178-187
30862702-3	2019	Here, we investigated the proposed water-mediated, hydrogen-bonded activation switch between the conserved NPxxY motif on transmembrane helix 7 (TMH7) and a conserved tyrosine in TMH5, which contributes to alpha1B-adrenoceptor (alpha1B-AR) and beta2-AR activation.	Hydrogen	51-59	adenosine A2a receptor	Homo sapiens	244-252
23247256-12	2013	Compound 7b scored the highest binding energy (-101.13 kcal/mol) against TGR crystal structure forming eight hydrogen bonds with the amino acid residues at the binding site of the receptor.	Hydrogen	109-117	thioredoxin reductase 3	Homo sapiens	73-76
14676193-9	2004	A network of hydrogen-bonded water molecules, found in crystal structures of GSTP1-1, connects the two active sites and the main chain carbonyl group of Tyr(50), thereby offering a mechanism for communication between the two active sites.	Hydrogen	13-21	glutathione S-transferase pi 1	Homo sapiens	77-84
14660656-3	2004	The anomalously enhanced (229 nm) ultraviolet resonance Raman (UVRR) imide II band reveals a common structural feature for gels of nondehydrated tau 2-19 and collagen I and insoluble paired helical filaments (PHFs) and collagen I of weak hydrogen bonding at proline carbonyls.	Hydrogen	238-246	microtubule associated protein tau	Homo sapiens	145-148
30550897-4	2019	The Lys634, Asn838, Gln839, Lys842, His901, and Asp925 residues were identified to play a major role in the UDP stabilization in the active site of OGT, where hydrogen bonding and pi-pi interactions mainly occur.	Hydrogen	159-167	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	148-151
14660656-8	2004	One implication of this assignment is that the fibrillation of hydrophilic tau is thermodynamically driven by the entropy gained as hydrogen-bonded water is freed, as for collagen I.	Hydrogen	132-140	microtubule associated protein tau	Homo sapiens	75-78
14744147-4	2004	The structural properties of G-CSF as a function of pH are evaluated in terms of properties such as hydrogen bonding, deviations from X-ray structure, helical/helical packing, and the atomic covariance fluctuation matrix of alpha-carbons.	Hydrogen	100-108	colony stimulating factor 3	Homo sapiens	29-34
23313634-4	2013	Overall, these studies showed that the combined presence of a phenyl group at C-3 and a methyl group at C-5 in the 1H,3H-pyrrolo[1,2-c]thiazole ring system is essential to ensure high cytotoxicty against MCF7 breast cancer cell lines.	Hydrogen	115-117	complement C5	Homo sapiens	104-107
30479395-9	2019	In addition, molecular docking studies indicate that the NDM-1 identified binds to different carbapenems through hydrogen and zinc coordination bonds.	Hydrogen	113-121	NDM-1	Klebsiella pneumoniae	57-62
23267765-12	2013	Of high importance, LF was able to confer histo-pathological protection of intestinal tissue post LPS administration, for both the 1h and 18 h LF pretreatment groups.	Hydrogen	131-133	lactotransferrin	Rattus norvegicus	20-22
14733550-1	2004	A remarkable, regiospecific hydrogenation zips around the approximately 4 nm perimeter of hexa-peri-hexabenzocoronenes (HBC) adding 18 hydrogen atoms, leading to the first peralkylated coronenes, in quantitative yields in some cases.	Hydrogen	28-36	hexosaminidase subunit alpha	Homo sapiens	90-94
30582942-2	2019	The H-17 and H-20 protons features the same values of 1H chemical shift, what causes that the structure elucidation require additional resolution enabled by 3D NMR experiments.	Hydrogen	54-56	H1.7 linker histone	Homo sapiens	4-8
14741383-6	2004	The substrate specificity of neutral SMases that hydrolyze SM, SPC, and monoradyl glycerophosphocholine, but not diradyl glycerophosphocholine, suggested that a hydrogen-bond donor at the C-2 or sn-2 position in the substrate is required for recognition by the enzymes.	Hydrogen	161-169	complement C2	Homo sapiens	188-191
23334436-3	2013	The best HypoGen pharmacophore model for ACC2 inhibitors (Hypo1_ACC2) consists of one hydrogen bond acceptor, one hydrophobic aliphatic and one hydrophobic aromatic feature, whereas the best pharmacophore (Hypo1_ACC1) for ACC1 consists of one additional hydrogen-bond donor (HBD) features.	Hydrogen	86-94	acetyl-CoA carboxylase beta	Homo sapiens	41-45
23334436-3	2013	The best HypoGen pharmacophore model for ACC2 inhibitors (Hypo1_ACC2) consists of one hydrogen bond acceptor, one hydrophobic aliphatic and one hydrophobic aromatic feature, whereas the best pharmacophore (Hypo1_ACC1) for ACC1 consists of one additional hydrogen-bond donor (HBD) features.	Hydrogen	86-94	acetyl-CoA carboxylase beta	Homo sapiens	64-68
23334436-3	2013	The best HypoGen pharmacophore model for ACC2 inhibitors (Hypo1_ACC2) consists of one hydrogen bond acceptor, one hydrophobic aliphatic and one hydrophobic aromatic feature, whereas the best pharmacophore (Hypo1_ACC1) for ACC1 consists of one additional hydrogen-bond donor (HBD) features.	Hydrogen	254-262	acetyl-CoA carboxylase beta	Homo sapiens	41-45
23334436-3	2013	The best HypoGen pharmacophore model for ACC2 inhibitors (Hypo1_ACC2) consists of one hydrogen bond acceptor, one hydrophobic aliphatic and one hydrophobic aromatic feature, whereas the best pharmacophore (Hypo1_ACC1) for ACC1 consists of one additional hydrogen-bond donor (HBD) features.	Hydrogen	254-262	acetyl-CoA carboxylase beta	Homo sapiens	64-68
14646147-6	2004	All the complementarity-determining regions (CDRs) of the Fab are involved in interaction with the C-terminal-side extracellular domain of TF through 19 hydrogen bonds.	Hydrogen	153-161	FA complementation group B	Homo sapiens	58-61
14646147-6	2004	All the complementarity-determining regions (CDRs) of the Fab are involved in interaction with the C-terminal-side extracellular domain of TF through 19 hydrogen bonds.	Hydrogen	153-161	coagulation factor III, tissue factor	Homo sapiens	139-141
30720265-6	2019	Moreover, the photocatalytic H2 evolution and photodegradation of bisphenol A for MoS2/CdS/g-C3N4 is up to 956 mumol h-1 g-1 and 95.2% under visible-light irradiation, respectively.	Hydrogen	29-31	CDP-diacylglycerol synthase 1	Homo sapiens	87-90
14646147-10	2004	These hydrogen-bonding and electrostatic interactions together with the wide buried areas contribute to the high affinity of the antibody toward TF, leading to the effective inhibition of the TF-initiated blood coagulation.	Hydrogen	6-14	coagulation factor III, tissue factor	Homo sapiens	145-147
14646147-10	2004	These hydrogen-bonding and electrostatic interactions together with the wide buried areas contribute to the high affinity of the antibody toward TF, leading to the effective inhibition of the TF-initiated blood coagulation.	Hydrogen	6-14	coagulation factor III, tissue factor	Homo sapiens	192-194
22776422-7	2013	MR- and ERbeta-mRNA were upregulated 1h after EP-stress in MS- but not in MS+ rats as compared to non-stressed littermates.	Hydrogen	37-39	estrogen receptor 2	Rattus norvegicus	8-14
30649875-6	2019	Structure-activity relationship analyses suggested that the binding potencies of PFASs to PPARalpha might depend on LBP binding cavity volume, hydrogen bond interactions, the number of perfluorinated carbons, and the hydrophobicity of PFASs.	Hydrogen	143-151	peroxisome proliferator activated receptor alpha	Homo sapiens	90-99
23349284-2	2013	These radii may be extracted from the laser spectroscopy of muonic hydrogen (mup, that is, a proton orbited by a muon).	Hydrogen	67-75	major urinary protein, pseudogene	Homo sapiens	77-80
14670455-6	2004	The changes in the vibrational characteristics (vibrational frequencies and infrared intensities) arising from the hydrogen bonding between HONO2 and H2O have been estimated by using the ab initio calculations at SCF and MP2 levels and B3LYP/6-31G(d,p) calculations.	Hydrogen	115-123	tryptase pseudogene 1	Homo sapiens	221-224
23841333-3	2013	Analysis of vibrational spectra and 13C and 1H NMR spectra revealed that thiol and glutamyl"s carboxylic groups are groups that cooperate in interaction with Cd2+ ions.	Hydrogen	44-46	CD2 molecule	Homo sapiens	158-161
30681870-4	2019	Experimental evidence points to charge transfer at the CdS-RGO interface playing a dominant role in the photocatalytic hydrogen production activity.	Hydrogen	119-127	CDP-diacylglycerol synthase 1	Homo sapiens	55-58
23564105-9	2013	However, the reduction of the expression of 8-OHdG, the decrease in the neuronal injury in the hippocampal CA1 sector, and the attenuation in brain water content were observed in hydrogen-treated mice.	Hydrogen	179-187	carbonic anhydrase 1	Mus musculus	107-110
23983797-4	2013	Serum TNF- alpha , IL-6, and IL-18 and histopathological score in the pancreas were reduced after hydrogen-rich saline treatment.	Hydrogen	98-106	interleukin 18	Rattus norvegicus	29-34
14673097-11	2003	We consider that these conformational features and water contacts are involved in stabilizing the hydrogen bond interactions between helix-3 residues of Ets-1 and DNA during the transcription process.	Hydrogen	98-106	ETS proto-oncogene 1, transcription factor	Homo sapiens	153-158
14683215-2	2003	Probing the hydroxyl stretch of methanol-OD oligomers in CCl4, the dynamics of the evolving hydrogen bonded network are measured with ultrashort (&lt;50 fs) pulses.	Hydrogen	92-100	C-C motif chemokine ligand 4	Homo sapiens	57-61
30537155-2	2019	The g-C3 N4 catalyst after optimizing the C-doping content actively generates increased amounts of H2 under visible light exposure with the highest H2 generation rate of 25.0 mumol h-1 , which is nearly 20 times above that using g-C3 N4 produced by conventional electric furnace heating of two identical monomers (1.3 mumol h-1 ).	Hydrogen	99-101	H1.5 linker histone, cluster member	Homo sapiens	181-184
14613766-9	2003	Hydrogen exchange in the alpha-helical fragment Trp1-Leu8 of zervamycin IIB was also analyzed using theoretical methods.	Hydrogen	0-8	tRNA-Pro (anticodon AGG) 2-5	Homo sapiens	48-52
30537155-2	2019	The g-C3 N4 catalyst after optimizing the C-doping content actively generates increased amounts of H2 under visible light exposure with the highest H2 generation rate of 25.0 mumol h-1 , which is nearly 20 times above that using g-C3 N4 produced by conventional electric furnace heating of two identical monomers (1.3 mumol h-1 ).	Hydrogen	99-101	H1.5 linker histone, cluster member	Homo sapiens	324-327
30537155-2	2019	The g-C3 N4 catalyst after optimizing the C-doping content actively generates increased amounts of H2 under visible light exposure with the highest H2 generation rate of 25.0 mumol h-1 , which is nearly 20 times above that using g-C3 N4 produced by conventional electric furnace heating of two identical monomers (1.3 mumol h-1 ).	Hydrogen	148-150	H1.5 linker histone, cluster member	Homo sapiens	181-184
14512739-0	2003	1H, 13C and 15N resonance assignments and secondary structure of the human protein tyrosine phosphatase, PRL-2.	Hydrogen	0-2	protein tyrosine phosphatase 4A2	Homo sapiens	105-110
31353663-5	2019	By computational molecular docking, dihydroxyphenyl group and hexyl group were selected as essential groups for interaction with the active site of alpha-glucosidase through hydrogen bonding and hydrophobic interaction, contributing to the great inhibitory activity.	Hydrogen	174-182	sucrase isomaltase (alpha-glucosidase)	Mus musculus	148-165
14512741-0	2003	1H, 15N, and 13C chemical shift assignments of the Escherichia coli nitrogen regulatory phosphocarrier IIA(Ntr).	Hydrogen	0-2	colicin Ia immunity protein	Escherichia coli	103-106
14512743-0	2003	Sequence-specific 1H, 13C and 15N resonance assignments of the SH3-SH2 domain pair from the human tyrosine kinase Lck.	Hydrogen	18-20	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	114-117
23202986-2	2013	In this work, we find that this coefficient strongly correlates with the temperature coefficient of the through-hydrogen-bond coupling, (3h)J(NC"), based on NMR measurements of protein GB3.	Hydrogen	112-120	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	185-188
30596495-0	2019	Kinetics of the Hydrogen Abstraction PAH +  OH   PAH Radical + H2O Reaction Class: An Application of the Reaction Class Transition State Theory (RC-TST) and Structure-Activity Relationship (SAR).	Hydrogen	16-24	thiosulfate sulfurtransferase	Homo sapiens	148-151
23457660-0	2013	Developing novel C-4 analogues of pyrrole-based antitubulin agents: weak but critical hydrogen bonding in the colchicine site.	Hydrogen	86-94	complement C4A (Rodgers blood group)	Homo sapiens	17-20
23555773-8	2013	BGA and BGB showed higher affinity than LacNAc and lactose due to generally stronger hydrogen bond interactions and water mediated hydrogen bonds with alpha1-2 fucose respectively.	Hydrogen	131-139	adrenoceptor alpha 1D	Homo sapiens	151-159
14623295-4	2003	However, the binding pattern of FKBP12-FK506 such as hydrogen bonding is significantly different from that of CyPA-CsA.	Hydrogen	53-61	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	32-38
14667706-5	2003	The full proton NMR assignment for gentamicin C-1 was obtained through the use of 1H 1D and 2D 1H-1H COSY measurements.	Hydrogen	82-84	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	46-49
14667706-5	2003	The full proton NMR assignment for gentamicin C-1 was obtained through the use of 1H 1D and 2D 1H-1H COSY measurements.	Hydrogen	95-97	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	46-49
14667706-5	2003	The full proton NMR assignment for gentamicin C-1 was obtained through the use of 1H 1D and 2D 1H-1H COSY measurements.	Hydrogen	95-97	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	46-49
30596495-1	2019	A reaction class transition state theory (RC-TST) augmented with structure-activity relationship (SAR) methodology is applied to predict high-pressure limit thermal rate constants for hydrogen abstraction by  OH radical from polycyclic aromatic hydrocarbons (PAHs) reaction class in the temperature range of 300-3000 K. The rate constants for the reference reaction of C6H6 +  OH   C6H5 + H2O is calculated by the canonical variational transition state theory (CVT) with small curvature tunneling (SCT).	Hydrogen	184-192	thiosulfate sulfurtransferase	Homo sapiens	45-48
30586302-5	2019	The resulting IL-1Ra/caspase-8(9) adducts are stabilized by hydrophobic and by few key hydrogen bonding interactions, formed by residues fully conserved across distinct caspases (-3, -6, -7, -8, and -9), and closely resemble the binding mode of the caspases inhibitors XIAP (X-linked inhibitor of apoptosis) and c-FLIP (cellular FLICE-like inhibitory protein).	Hydrogen	87-95	interleukin 1 receptor antagonist	Homo sapiens	14-20
12900436-8	2003	Renal microvascular CYP2C11 and CYP2C23 mRNA levels were reduced in the ANG/HS-HS group compared with both the NS and HS groups.	Hydrogen	76-78	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	20-27
12900436-8	2003	Renal microvascular CYP2C11 and CYP2C23 mRNA levels were reduced in the ANG/HS-HS group compared with both the NS and HS groups.	Hydrogen	76-78	cytochrome P450, family 2, subfamily c, polypeptide 23	Rattus norvegicus	32-39
12900436-8	2003	Renal microvascular CYP2C11 and CYP2C23 mRNA levels were reduced in the ANG/HS-HS group compared with both the NS and HS groups.	Hydrogen	79-81	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	20-27
12900436-8	2003	Renal microvascular CYP2C11 and CYP2C23 mRNA levels were reduced in the ANG/HS-HS group compared with both the NS and HS groups.	Hydrogen	79-81	cytochrome P450, family 2, subfamily c, polypeptide 23	Rattus norvegicus	32-39
23148532-5	2012	MafA forms base-specific hydrogen bonds with the flanking G(-5)C(-4) and central C(0)/G(0) bases, but not with the core-TGA bases.	Hydrogen	25-33	MAF bZIP transcription factor A	Homo sapiens	0-4
23151632-4	2012	This conformation is stabilized through two weak C-H...O hydrogen bonds facilitated by the alpha(1-2) linkage.	Hydrogen	57-65	adrenoceptor alpha 1D	Homo sapiens	91-100
30520261-5	2019	Importantly, a single PSC can drive three reformed electrolyzers in series for hydrogen production by carefully matching the operating point of the electrolyzer with the maximum power point of the photovoltaic device, thereby, yielding a H2 evolution rate of 1.77 mg h-1 for the whole PV-EC system.	Hydrogen	79-87	H1.5 linker histone, cluster member	Homo sapiens	267-270
22891787-8	2012	Furthermore, T cell proliferation was significantly inhibited in the presence of hydrogen in vitro, accompanied by less production of interleukin-2 and interferon-gamma.	Hydrogen	81-89	interleukin 2	Rattus norvegicus	134-147
22891787-8	2012	Furthermore, T cell proliferation was significantly inhibited in the presence of hydrogen in vitro, accompanied by less production of interleukin-2 and interferon-gamma.	Hydrogen	81-89	interferon gamma	Rattus norvegicus	152-168
12968905-5	2003	The binding energy corrected by basis set superposition error with the MP2/cc-pVTZ method based on the MP2/6-31G geometry is -4.37 kcal/mol, which is as strong as the conventional hydrogen bonding.	Hydrogen	180-188	tryptase pseudogene 1	Homo sapiens	71-74
30683882-4	2019	An ensuing experimental investigation into the G9a-like protein (GLP)-inhibitor complex demonstrated that N+-C-H   O hydrogen bonds affect the activity of the inhibitors against the target enzyme.	Hydrogen	117-125	euchromatic histone lysine methyltransferase 1	Homo sapiens	47-63
13679164-5	2003	The COX1 selectivity of the new compounds was tentatively explained by means of a docking study of one of the more active compounds tested on both COX isoenzymes (7d), which indicated a different number of hydrogen bonding interactions with the Arg120 of the active sites of the two enzymes, and therefore, an energetically favored interaction (3.5 kcal/mol) with COX1, compared with COX2.	Hydrogen	206-214	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	4-8
30683882-4	2019	An ensuing experimental investigation into the G9a-like protein (GLP)-inhibitor complex demonstrated that N+-C-H   O hydrogen bonds affect the activity of the inhibitors against the target enzyme.	Hydrogen	117-125	euchromatic histone lysine methyltransferase 1	Homo sapiens	65-68
12901915-4	2003	Within this series, several compounds have excellent in vitro potency and our computational models accurately justify the structure-activity relationships (SARs) and highlight essential hydrogen bonding residues and hydrophobic pockets within the catalytic domain of PARP-1.	Hydrogen	186-194	poly (ADP-ribose) polymerase 1	Rattus norvegicus	267-273
23079492-0	2012	Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a 1H-NMR method to assess deacetylase activity.	Hydrogen	74-76	sirtuin 2	Homo sapiens	28-33
29684685-6	2019	In this work we present epitope identification of the hCC-HCC3 complex using methods such as affinity chromatography, epitope excision and extraction MS approach, enzyme-linked immunosorbent assay and hydrogen-deuterium exchange mass spectrometry (HDX MS).	Hydrogen	201-209	C-C motif chemokine ligand 14	Homo sapiens	58-62
22696309-4	2012	The MP2/aug-cc-pVTZ c-C(3)H(2)   H-F complex potential energy surface turns out to be an asymmetric deep single well, while asymmetric double wells are found for the c-C(3)H(2)   H-Cl and c-C(3)H(2)   H-Br complexes, with an energy barrier of 4.1 kcal mol(-1) for proton transfer along the hydrogen bond in the latter complex.	Hydrogen	290-298	tryptase pseudogene 1	Homo sapiens	4-7
12876340-10	2003	This in turn suggests that in the hydrated structures the well ordered water structure in the central core is involved in stabilizing the B13 side-chain conformations and modulating charge repulsions among the six B13 glutamates if they are not protonated, or that, as is considered more likely, the water structure plays an important role in modulating the pK(a) values of the B13 glutamates, resulting in protonation and hydrogen-bond formation.	Hydrogen	423-431	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	138-141
30458105-7	2019	In addition, 1H NMR and CD experiments revealed, in deionized water, the formation of type II beta-turns into the ELP block upon temperature increase.	Hydrogen	13-15	nuclear receptor subfamily 5 group A member 1	Homo sapiens	114-117
12854955-2	2003	In this contribution I report on two illustrative examples, p21ras and p57, revealing that such mutations have an effect on specific structural deficiencies in the packing of the protein structure, i. e., on backbone hydrogen bonds insufficiently shielded from water attack.	Hydrogen	217-225	HRas proto-oncogene, GTPase	Homo sapiens	60-66
12867442-5	2003	An adh mutant was constructed and found to be incapable of growth in media in which ethanol was both the carbon source and electron donor for sulfate reduction or was only the carbon source, with hydrogen serving as electron donor.	Hydrogen	196-204	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	3-6
12867442-8	2003	These results, as well as the high level of expression of adh in wild-type cells on media in which lactate, pyruvate, formate, or hydrogen served as the sole electron donor for sulfate reduction, indicate that ORF2977 Adh contributes to the energy metabolism of D. vulgaris under a wide variety of metabolic conditions.	Hydrogen	130-138	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	58-61
12867442-9	2003	A hydrogen cycling mechanism is proposed in which protons and electrons originating from cytoplasmic ethanol oxidation by ORF2977 Adh are converted to hydrogen or hydrogen equivalents, possibly by a putative H(2)-heterodisulfide oxidoreductase complex, which is then oxidized by periplasmic Fe-only hydrogenase to generate a proton gradient.	Hydrogen	2-10	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	130-133
12867442-9	2003	A hydrogen cycling mechanism is proposed in which protons and electrons originating from cytoplasmic ethanol oxidation by ORF2977 Adh are converted to hydrogen or hydrogen equivalents, possibly by a putative H(2)-heterodisulfide oxidoreductase complex, which is then oxidized by periplasmic Fe-only hydrogenase to generate a proton gradient.	Hydrogen	151-159	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	130-133
12867442-9	2003	A hydrogen cycling mechanism is proposed in which protons and electrons originating from cytoplasmic ethanol oxidation by ORF2977 Adh are converted to hydrogen or hydrogen equivalents, possibly by a putative H(2)-heterodisulfide oxidoreductase complex, which is then oxidized by periplasmic Fe-only hydrogenase to generate a proton gradient.	Hydrogen	151-159	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	130-133
22896701-4	2012	In the present study, we combine small angle x-ray scattering, hydrogen-deuterium exchange, and surface plasmon resonance to develop a structural model describing the allosteric regulation of uPAR.	Hydrogen	63-71	plasminogen activator, urokinase receptor	Homo sapiens	192-196
22847004-1	2012	We have applied hydrogen-deuterium exchange mass spectrometry, in conjunction with differential scanning calorimetry and protein stability analysis, to examine solution dynamics of the integrin alpha1 I domain induced by the binding of divalent cations, full-length type IV collagen, or a function-blocking monoclonal antibody.	Hydrogen	16-24	integrin subunit alpha 1	Homo sapiens	185-200
30728903-3	2019	Here, we have identified the fragments of CD160 interacting with HVEM using ELISA tests, hydrogen/deuterium studies, affinity chromatography and mass spectrometry (MS).	Hydrogen	89-97	CD160 molecule	Homo sapiens	42-47
22800498-3	2012	To develop potent, stable ligands of GPR103 with low molecular weight, we have designed a series of aza-beta(3)-containing 26RFa((20-26)) analogues for their propensity to establish intramolecular hydrogen bonds, and we have evaluated their ability to increase [Ca(2+)](i) in GPR103-transfected cells.	Hydrogen	197-205	pyroglutamylated RFamide peptide receptor	Mus musculus	37-43
12956066-5	2003	The choice of NBS or chlorine for allyl halide synthesis is shown to depend on the potential to avoid competing reactions, such as halolactonization of leucine derivatives with chlorine, and hydrogen abstraction and bromine incorporation at multiple sites on treatment of isoleucine derivatives with NBS.	Hydrogen	191-199	nibrin	Homo sapiens	14-17
30728903-4	2019	By combining hydrogen/deuterium exchange and mass spectrometry (HDX-MS) we obtained key information about the tertiary structure of CD160, predicting the 3D structure of the CD160-HVEM complex.	Hydrogen	13-21	CD160 molecule	Homo sapiens	132-137
30728903-4	2019	By combining hydrogen/deuterium exchange and mass spectrometry (HDX-MS) we obtained key information about the tertiary structure of CD160, predicting the 3D structure of the CD160-HVEM complex.	Hydrogen	13-21	CD160 molecule	Homo sapiens	174-179
12909033-0	2003	Localized changes in the structural stability of myoglobin upon adsorption onto silica particles, as studied with hydrogen/deuterium exchange mass spectrometry.	Hydrogen	114-122	myoglobin	Homo sapiens	49-58
22820668-0	2012	Charge-order driven proton arrangement in a hydrogen-bonded charge-transfer complex based on a pyridyl-substituted TTF derivative.	Hydrogen	44-52	ras homolog family member H	Homo sapiens	115-118
22820668-1	2012	A unique N(+)-H   N hydrogen-bonded (H-bonded) dimer motif based on partially oxidized pyridyl-substituted TTF was constructed in the charge-transfer complex.	Hydrogen	20-28	ras homolog family member H	Homo sapiens	107-110
12944176-5	2003	1H nuclear magnetic resonance spectroscopy and multivariate statistical data analysis of urinary spectra from animals given the PPARalpha and -delta agonists identified two new potential biomarkers of peroxisome proliferation--N-methylnicotinamide (NMN) and N-methyl-4-pyridone-3-carboxamide (4PY)--both endproducts of the tryptophan-nicotinamide adenine dinucleotide (NAD+) pathway.	Hydrogen	0-2	peroxisome proliferator activated receptor alpha	Rattus norvegicus	128-137
30547571-4	2019	Density functional theory calculations show that the FeCoP have the optimal hydrogen absorption energy than that of FeP and CoP.	Hydrogen	76-84	caspase recruitment domain family member 16	Homo sapiens	55-58
30560651-0	2019	Site-Selective Deposition of Reductive and Oxidative Dual Cocatalysts To Improve the Photocatalytic Hydrogen Production Activity of CaIn2S4 with a Surface Nanostep Structure.	Hydrogen	100-108	nucleoporin 214	Homo sapiens	132-136
22609246-7	2012	We found that rIL-10, when given concurrently or 1h after LPS, strongly inhibited LPS-induced TF procoagulant activity in canine PBMC and monocytes.	Hydrogen	49-51	interleukin 10	Rattus norvegicus	14-20
22830687-7	2012	Test calculations by MP2 and DFT functionals with homogeneous and heterogeneous solvation, involving hydrogen bonding, vdW interaction, metal-ligand binding, cation-pi, and ionic interaction, show the robustness and adaptability of the EDA-PCM method.	Hydrogen	101-109	tryptase pseudogene 1	Homo sapiens	21-24
22525098-0	2012	Catalytic mechanism of human UDP-glucose 6-dehydrogenase: in situ proton NMR studies reveal that the C-5 hydrogen of UDP-glucose is not exchanged with bulk water during the enzymatic reaction.	Hydrogen	45-53	complement C5	Homo sapiens	101-104
30713665-5	2018	As demonstrated by enzyme linked immunosorbent assay and 16S rDNA sequence analysis of stool samples, the consumption of hydrogen-rich water for two months significantly reduced serum malondialdehyde, interleukin-1, interleukin-6, tumour necrosis factor-alpha levels; then significantly increased serum superoxide dismutase, total antioxidant capacity levels and haemoglobin levels of whole blood.	Hydrogen	121-129	interleukin 1 alpha	Homo sapiens	201-214
22662961-0	2012	Decomposition reaction rate of BCl3-C3H6(propene)-H2 in the gas phase.	Hydrogen	50-52	BCL3 transcription coactivator	Homo sapiens	31-35
30351453-2	2019	Photocatalytic ethanol dehydrogenation-acetalization to prepare value-added 1,1-diethoxyethane and H2 was achieved over non-precious metal CdS/Ni-MoS2 catalyst under visible light.	Hydrogen	99-101	CDP-diacylglycerol synthase 1	Homo sapiens	139-142
22747771-10	2012	In addition to the electron-withdrawing character, hydrogen bond--donating groups, hydrophobic and negative ionic groups positively contribute to the HMG-CoA reductase inhibition.	Hydrogen	51-59	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	150-167
29279008-7	2019	The temperature-dependent free energy landscapes consist of multiple metastable states stabilized by non-native contacts and hydrogen bonds in RRM2, thus rendering the RRM2 more prone to misfolding.	Hydrogen	125-133	ribonucleotide reductase regulatory subunit M2	Homo sapiens	143-147
22705788-3	2012	The interface of the K5-K14 coiled-coil heterodimer has asymmetric salt bridges, hydrogen bonds and hydrophobic contacts, and its surface exhibits a notable charge polarization.	Hydrogen	81-89	keratin 14	Mus musculus	24-27
29279008-7	2019	The temperature-dependent free energy landscapes consist of multiple metastable states stabilized by non-native contacts and hydrogen bonds in RRM2, thus rendering the RRM2 more prone to misfolding.	Hydrogen	125-133	ribonucleotide reductase regulatory subunit M2	Homo sapiens	168-172
30599913-8	2019	The LCH inhibitor is surrounded by specific ATP-binding pocket in which it is stabilized by forming hydrogen bonds and hydrophobic interactions.	Hydrogen	100-108	LCH	Homo sapiens	4-7
22611242-4	2012	Using hydrogen/deuterium exchange, we demonstrate that ligation globally rigidifies the TCR, which via entropic and packing effects will promote associations with neighboring proteins and enhance the stability of existing complexes.	Hydrogen	6-14	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	88-91
22549774-2	2012	Hydrogen-deuterium exchange combined with mass spectrometry and small-angle x-ray scattering showed that activation of the cytokine function of the 528-amino acid human tyrosyl-tRNA synthetase was associated with pinpointed uncovering of a miniature internal ELR tripeptide that triggers receptor signaling.	Hydrogen	0-8	tyrosyl-tRNA synthetase 1	Homo sapiens	169-192
30525168-3	2018	With the predesigned nitrogen position and structural features of COP materials, the obtained CCOPTDP-FeNi-SiO2 catalyst affords a remarkable bifunctional performance with a positive half-wave potential (0.89 V vs. reversible hydrogen electrode: RHE, superior to the benchmark Pt/C) for ORR activity, and a low overpotential (0.31 V better than the benchmark IrO2) at 10 mA cm-2 for OER activity in alkaline solution.	Hydrogen	226-234	caspase recruitment domain family member 16	Homo sapiens	66-69
22543062-11	2012	In addition, hydrogen mitigated inflammatory response and neutrophils infiltration with suppressing the activity of P-p38 MAPK, P-JNk and NF-kappaB.	Hydrogen	13-21	mitogen-activated protein kinase 8	Rattus norvegicus	130-133
22543062-13	2012	Furthermore, the up-regulation of cleaved caspase-3, Bax and down-regulation of Bcl-xl expression were blocked by hydrogen treatment.	Hydrogen	114-122	BCL2 associated X, apoptosis regulator	Rattus norvegicus	53-56
30074283-4	2018	The optimized LaNiO3 /CdS sample without the assistance of any cocatalyst (e.g., Pt) delivers a high H2 production rate of 74 mumol h-1 (e.g., 3700 mumol h-1  g-1 ), which is substantially superior to the individual LaNiO3 and CdS.	Hydrogen	101-103	CDP-diacylglycerol synthase 1	Homo sapiens	22-25
22427516-7	2012	Moreover, the increased levels of iNOS, nitrotyrosine, Toll-like receptor-4, BNP, PTX3, and TBARS in the HS group were inhibited by RHT.	Hydrogen	105-107	pentraxin 3	Rattus norvegicus	82-86
30074283-4	2018	The optimized LaNiO3 /CdS sample without the assistance of any cocatalyst (e.g., Pt) delivers a high H2 production rate of 74 mumol h-1 (e.g., 3700 mumol h-1  g-1 ), which is substantially superior to the individual LaNiO3 and CdS.	Hydrogen	101-103	CDP-diacylglycerol synthase 1	Homo sapiens	227-230
22497458-3	2012	The reaction is initiated by a barrierless addition of the phenyl radical to the terminal carbon atom of the 1,3-butadiene (C1/C4) to form a bound intermediate; the latter underwent hydrogen elimination from the terminal CH(2) group of the 1,3-butadiene molecule leading to 1-phenyl-trans-1,3-butadiene through a submerged barrier.	Hydrogen	182-190	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	124-129
30074283-6	2018	The greatly improved H2 production performance of LaNiO3 /CdS is attributed to the facilitated separation and transport of photoinduced charge carriers, as evidenced by photoelectrochemical (PEC) analyses, such as photoluminscence spectroscopy, transient photocurrent responses, and electrochemical impedance spectroscopy.	Hydrogen	21-23	CDP-diacylglycerol synthase 1	Homo sapiens	58-61
22768949-5	2012	Instead, the phosphate group of S10 seems to form a persistent intramolecular salt bridge with R8, an interaction that can provoke a major structural change and alter the hydrogen-bonding regime in the H3-HP1 complex.	Hydrogen	171-179	chromobox 5	Homo sapiens	205-208
30173066-5	2018	Electrochemical, scanning electron microscopy, and microbial community analyses suggested that GAC might improve the performance of MES by accelerating direct and indirect (via H2) electron transfer because GAC could provide a high electrode surface and a favorable mass transport.	Hydrogen	177-179	glutaminase	Homo sapiens	95-98
30973277-8	2018	The Gene Ontology and KEGG enrichment analyses identified a large number of proteins and biological processes that may responsible for the protective effect of hydrogen, including VEGFA, PDGFB, IGFBP3, EDN1, NADPH oxidase, the coagulation cascade, etc.	Hydrogen	160-168	insulin like growth factor binding protein 3	Homo sapiens	194-200
30973277-9	2018	Conclusions: Molecular hydrogen protects AECIIs from hyperoxic injury by complex mechanisms involving a variety of proteins and biological processes, such as VEGFA, PDGFB, IGFBP3, EDN1, NADPH oxidase and the coagulation cascade.	Hydrogen	23-31	insulin like growth factor binding protein 3	Homo sapiens	172-178
22424937-7	2012	Serum IL-6 level peaked at 3h (1.89 +- 0.10 ng/ml) and serum TNF-alpha peaked at 1h (1.11 +- 0.01 ng/ml).	Hydrogen	81-83	tumor necrosis factor	Canis lupus familiaris	61-70
30078216-4	2018	This study was designed to investigate the interactions between hydrogen sulfide (H2 S) and nuclear FoxO1 in DCM.	Hydrogen	82-84	forkhead box O1	Mus musculus	100-105
22467566-1	2012	Four- and five-bond heteronuclear J-couplings between the hydrogen H-8 and carbons C-6 and C-2 in a series of 7- and 9-benzyl substituted purine derivaties with variuous substituents in positions 2 and 6 were studied by coupled (13)  C NMR and H,C-HMBC experiments and by DFT calculations.	Hydrogen	58-66	complement C2	Homo sapiens	91-94
30078216-11	2018	In addition, H2 S induced FoxO1 phosphorylation and nuclear exclusion in vitro and in vivo, and this function was not inhibited by MK-2206 2HCl.	Hydrogen	13-15	forkhead box O1	Mus musculus	26-31
30360084-2	2018	Herein, hydrogen thermal pretreatment of the Pt single atoms on porous nanorods of CeO2 (Pt1/ PN-CeO2) induced the formation of isolated bimetallic PtCe sites as a new type of active center for CO oxidation.	Hydrogen	8-16	zinc finger protein 77	Homo sapiens	89-92
22316066-15	2012	The formation of hydrogen bonds between the lyso-PAF molecules as well as the stronger hydration of its hydrophilic fragment can be the key factor differentiating the activity of PAF and lyso-PAF in the investigated systems as well as in the native biomembranes.	Hydrogen	17-25	PCNA clamp associated factor	Homo sapiens	49-52
22316066-15	2012	The formation of hydrogen bonds between the lyso-PAF molecules as well as the stronger hydration of its hydrophilic fragment can be the key factor differentiating the activity of PAF and lyso-PAF in the investigated systems as well as in the native biomembranes.	Hydrogen	17-25	PCNA clamp associated factor	Homo sapiens	179-182
22316066-15	2012	The formation of hydrogen bonds between the lyso-PAF molecules as well as the stronger hydration of its hydrophilic fragment can be the key factor differentiating the activity of PAF and lyso-PAF in the investigated systems as well as in the native biomembranes.	Hydrogen	17-25	PCNA clamp associated factor	Homo sapiens	179-182
22320344-2	2012	We have not only took full advantage of published X-ray structural data for the ovine COX-1 cocrystallized with bromoaspirin, but we also have improved that data through computation, finding good estimates for the hydrogen atom positions at the residues of the binding pocket, and repositioning the Ser530Ac[Br;H] lateral chain and salicylic acid by total energy minimization procedures employing LDA and GGA+D exchange-correlation functionals.	Hydrogen	214-222	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	86-91
22412508-4	2012	The crystal packing is dominated by two strong N-H O hydrogen bonds involving the amide groups and forming R(2) (2)(8) rings and C(4) chains.	Hydrogen	53-61	complement C4A (Rodgers blood group)	Homo sapiens	129-133
30360084-3	2018	The evolutions of Pt1/ PN-CeO2 catalysts during the hydrogen pretreatment and CO oxidation were examined by various in situ techniques including infrared, ambient-pressure X-ray photoelectron and X-ray absorption spectroscopy.	Hydrogen	52-60	zinc finger protein 77	Homo sapiens	18-21
30195263-6	2018	It is hypothesized that the free phosphate group affects the microenvironment around the target cytosine by activating the incoming nucleophile through hydrogen bonding with the water molecule, thus facilitating nucleophilic attack on the cytosine C-4 carbon.	Hydrogen	152-160	complement C4A (Rodgers blood group)	Homo sapiens	248-251
22325942-2	2012	The crystal structures of compounds 14 and 23 in complex with BACE-1 reveal hydrogen bond interactions with the protein important for achieving potent inhibition.	Hydrogen	76-84	beta-site APP cleaving enzyme 1	Mus musculus	62-68
30096627-7	2018	Hydrogen bond interactions were critical for the binding of both peptides to the alpha-glucosidase and alpha-amylase.	Hydrogen	0-8	sucrase-isomaltase	Homo sapiens	81-98
22227798-0	2012	Using hydrogen/deuterium exchange mass spectrometry to study conformational changes in granulocyte colony stimulating factor upon PEGylation.	Hydrogen	6-14	colony stimulating factor 3	Homo sapiens	87-124
12958837-9	2003	CONCLUSION: A hydrogen-bond between 14-methyl group of (-) huperzine A and the main-chain oxygen of His 440 is necessary for the highly acetylcholinesterase inhibitory activity of huperzine A.	Hydrogen	14-22	acetylcholinesterase	Rattus norvegicus	136-156
30524648-10	2018	Conclusions: Multinuclear 1H/19F MRI allows the simultaneous assessment of inflammation and elastin remodeling in a murine MI model.	Hydrogen	26-28	elastin	Mus musculus	92-99
12751787-10	2003	FT Docking of PHGPx molecules allowed reactions of Sec-46 with either Cys-66", Cys-107", Cys-168" or Cys-148", the latter option being most likely as judged by the number of proposed intermediates with reasonable hydrogen bonds, interaction energies and interface areas.	Hydrogen	213-221	glutathione peroxidase 4	Homo sapiens	14-19
22333294-9	2012	The neuronal density 3 3+-2 1 cells/mm in CA1 region of the ischemic rats increased to 21 7+-2 6 cells/mm after they were treated with hydrogen gas.	Hydrogen	135-143	carbonic anhydrase 1	Rattus norvegicus	42-45
30344682-0	2018	Hydrogen attenuated oxidized low-density lipoprotein-induced inflammation through the stimulation of autophagy via sirtuin 1.	Hydrogen	0-8	sirtuin 1	Mus musculus	115-124
22238126-8	2012	Significantly diminished interactions were seen for the aniline of APV bound in PR1 (M) and PR2 relative to the strong hydrogen bonds observed in PR1, consistent with 15- and 19-fold weaker inhibition, respectively.	Hydrogen	119-127	transmembrane protein 37	Homo sapiens	146-149
12620371-9	2003	Formalin treatment resulted in a rapid (within 1h), long-lasting (up to 96h) upregulation of PKG-I protein expression.	Hydrogen	47-49	protein kinase cGMP-dependent 1	Rattus norvegicus	93-98
30344682-7	2018	Small interfering (si)RNA against sirtuin 1 (SIRT1) was employed to investigate the mechanism underlying hydrogen-activated autophagy.	Hydrogen	105-113	sirtuin 1	Mus musculus	45-50
30344682-10	2018	SIRT1 mediated the upregulation of autophagic flux via hydrogen in ox-LDL-treated macrophages.	Hydrogen	55-63	sirtuin 1	Mus musculus	0-5
12588172-0	2003	Germanium-rich pentaruthenium carbonyl clusters including Ru(5)(CO)(11)(mu-GePh(2))(4)(mu(5)-C) and its reactions with hydrogen.	Hydrogen	119-127	gephyrin	Homo sapiens	75-79
12588172-5	2003	Reaction of 4 with hydrogen at 150 degrees C yielded the compound Ru(5)(CO)(10)(mu-GePh(2))(2)(mu(3)-GePh)(2)(mu(3)-H)(mu(4)-CH), 5, by loss of benzene and conversion of two of the bridging GePh(2) groups into triply bridging GePh groups.	Hydrogen	19-27	gephyrin	Homo sapiens	83-87
12588172-5	2003	Reaction of 4 with hydrogen at 150 degrees C yielded the compound Ru(5)(CO)(10)(mu-GePh(2))(2)(mu(3)-GePh)(2)(mu(3)-H)(mu(4)-CH), 5, by loss of benzene and conversion of two of the bridging GePh(2) groups into triply bridging GePh groups.	Hydrogen	19-27	gephyrin	Homo sapiens	101-105
12588172-5	2003	Reaction of 4 with hydrogen at 150 degrees C yielded the compound Ru(5)(CO)(10)(mu-GePh(2))(2)(mu(3)-GePh)(2)(mu(3)-H)(mu(4)-CH), 5, by loss of benzene and conversion of two of the bridging GePh(2) groups into triply bridging GePh groups.	Hydrogen	19-27	gephyrin	Homo sapiens	101-105
12588172-5	2003	Reaction of 4 with hydrogen at 150 degrees C yielded the compound Ru(5)(CO)(10)(mu-GePh(2))(2)(mu(3)-GePh)(2)(mu(3)-H)(mu(4)-CH), 5, by loss of benzene and conversion of two of the bridging GePh(2) groups into triply bridging GePh groups.	Hydrogen	19-27	gephyrin	Homo sapiens	101-105
22499511-8	2012	Altering lysine will probably change the hydrophobic interactions, the hydrogen bonds or the electrostatic interactions formed between PICK1 PDZ domain and GluR2 C terminal; accordingly, that will change the binding capacity between PICK1 and GluR2 in varying degrees.	Hydrogen	71-79	protein interacting with PRKCA 1	Homo sapiens	233-238
30483387-3	2018	Materials and Methods: In this study, 1H-NMR metabolomics platform was used to seek the discriminating serum metabolites in malignant papillary thyroid carcinoma (PTC) compared to benign multinodular goiter (MNG) and healthy subjects and also to better understand the disease mechanisms using bioinformatics analysis.	Hydrogen	38-40	coiled-coil domain containing 6	Homo sapiens	163-166
22268528-4	2012	Hydrogen bonding interaction is found to occur between the protons at C-2 on the imidazolium ring and the oxygen atoms in [NO(3)](-) anions, and the interaction varies as a function of the basicity of the counterions and the hydrophobicity of the side-chains bonded to the imidizolium ring.	Hydrogen	0-8	complement C2	Homo sapiens	70-73
30208709-6	2018	The spectra of TrpH+(H2O) m=1,2, recorded by infrared multiphoton dissociation (IRMPD), reveal broad features in the NH stretching region of the NH3+ group, indicating strong hydrogen bonding in acceptor-donor configuration with the benzene ring for the first water molecule, while the second water appears to attach to a less strongly perturbing site, yielding unique transitions associated with the free OH stretching fundamentals.	Hydrogen	175-183	tryptophan hydroxylase 1	Homo sapiens	15-19
22244199-7	2012	Arg73 forms an intermolecular hydrogen bond with Ser76, and this appears to be a likely driving force that directs the self-assembly of SSB on DNA.	Hydrogen	30-38	Single-stranded DNA-binding protein	Klebsiella pneumoniae	136-139
12559908-10	2003	Examination of the RT structures revealed that K331 in p51 makes multiple hydrogen bond contacts with residues in the p66 loop spanned by W401 and W414.	Hydrogen	74-82	tumor protein p63	Homo sapiens	55-58
30272827-2	2018	Herein, a hierarchical hollow black TiO2 /MoS2 /CdS tandem heterojunction photocatalyst, which allows broad-spectrum absorption, thus delivering enhanced hydrogen evolution performance is designed and synthesized.	Hydrogen	154-162	CDP-diacylglycerol synthase 1	Homo sapiens	48-51
12620670-2	2003	Earlier studies have explained reasonably well the complex formation with cupric ion, while in this work extensive 1H NMR measurements have been performed for free gonadotropin-releasing hormone (GnRH) and its complexes with Ni(II) in DMSO (dimethyl sulfoxide) solution.	Hydrogen	115-117	Progonadoliberin-1	Ovis aries	164-194
12620670-2	2003	Earlier studies have explained reasonably well the complex formation with cupric ion, while in this work extensive 1H NMR measurements have been performed for free gonadotropin-releasing hormone (GnRH) and its complexes with Ni(II) in DMSO (dimethyl sulfoxide) solution.	Hydrogen	115-117	Progonadoliberin-1	Ovis aries	196-200
22170046-6	2012	The major glycoform of CASQ (GlcNAc(2)Man(9)) found in the proximal endoplasmic reticulum can severely hinder formation of the back-to-back interface, potentially preventing premature Ca(2+)-dependent polymerization of CASQ and ensuring its continuous mobility to the SR. Only trimmed glycans can stabilize both front-to-front and the back-to-back interfaces of CASQ through extensive hydrogen bonding and electrostatic interactions.	Hydrogen	385-393	calsequestrin 1	Homo sapiens	23-27
22170046-6	2012	The major glycoform of CASQ (GlcNAc(2)Man(9)) found in the proximal endoplasmic reticulum can severely hinder formation of the back-to-back interface, potentially preventing premature Ca(2+)-dependent polymerization of CASQ and ensuring its continuous mobility to the SR. Only trimmed glycans can stabilize both front-to-front and the back-to-back interfaces of CASQ through extensive hydrogen bonding and electrostatic interactions.	Hydrogen	385-393	calsequestrin 1	Homo sapiens	219-223
22170046-6	2012	The major glycoform of CASQ (GlcNAc(2)Man(9)) found in the proximal endoplasmic reticulum can severely hinder formation of the back-to-back interface, potentially preventing premature Ca(2+)-dependent polymerization of CASQ and ensuring its continuous mobility to the SR. Only trimmed glycans can stabilize both front-to-front and the back-to-back interfaces of CASQ through extensive hydrogen bonding and electrostatic interactions.	Hydrogen	385-393	calsequestrin 1	Homo sapiens	219-223
12483678-3	2003	We illustrate the method by improving solvation parameters in the energy function EEF1, which consists of the CHARMM19 polar hydrogen force field augmented by a Gaussian solvation term.	Hydrogen	125-133	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	82-86
30272827-4	2018	Consequently, the photocatalytic hydrogen rate of the black TiO2 /MoS2 /CdS tandem heterojunction is as high as 179 micromol h-1 per 20 mg photocatalyst under visible-light irradiation, which is almost 3 times higher than that of black TiO2 /MoS2 heterojunctions (57.2 micromol h-1 ).	Hydrogen	33-41	CDP-diacylglycerol synthase 1	Homo sapiens	72-75
29864684-4	2018	The active compounds formed hydrogen bond at DHFR binding site between N1-nitrogen of the pyridazine ring with Glu30; the carbonyl group with Trp24, Arg70 or Lys64; pi-cation interaction with Arg22 and pi-pi interaction with Phe31 residues.	Hydrogen	28-36	dihydrofolate reductase	Homo sapiens	45-49
12464242-2	2003	From a consideration of specific interactions between drug substrates for human CYP2 family enzymes and the putative active sites of CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, it is likely that the number and disposition of hydrogen bond donor/acceptors and aromatic rings within the various P450 substrate molecules determines their enzyme selectivity and binding affinity, together with directing their preferred routes of metabolism by the CYP2 enzymes concerned.	Hydrogen	242-250	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	157-163
29869749-0	2018	1H, 13C, 15N NMR resonance assignments and secondary structure determination of the extra-cellular domain from the human proapoptotic TRAIL-R2 death receptor 5 (DR5-ECD).	Hydrogen	0-2	TNF receptor superfamily member 10b	Homo sapiens	143-159
12467418-2	2002	B3LYP/aug-cc-pVDZ and MP2/6-31+G calculations of the reactions of HS(-) with small cyclic disulfides (dithiirane, 1,2-dithietane, 1,2-dithiolane, and 1,2-dithiane) were performed to determine the reaction mechanism.	Hydrogen	66-71	tryptase pseudogene 1	Homo sapiens	22-30
29869749-0	2018	1H, 13C, 15N NMR resonance assignments and secondary structure determination of the extra-cellular domain from the human proapoptotic TRAIL-R2 death receptor 5 (DR5-ECD).	Hydrogen	0-2	TNF receptor superfamily member 10b	Homo sapiens	161-164
30119179-0	2018	Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived mesenchymal stem cells in vivo.	Hydrogen	0-8	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	62-65
12437383-10	2002	In the absence of top 1, the C17 hydroxyl of CPT is involved in ester exchange (nicking of the DNA sugar-phosphate backbone followed by covalent joining of free phosphate to C17) whereas its C20 carboxyl forms two hydrogen bonds with the same guanine nucleotide at the opposite end of the broken DNA backbone.	Hydrogen	214-222	cytokine like 1	Homo sapiens	29-32
12437383-13	2002	In the presence of top 1, after CPT conversion to the carboxylate form and DNA nicking, the C17 hydroxyl makes a branching hydrogen bond with N1 and N3 of guanine while the C20 carboxyl makes two hydrogen bonds with the NH of Tyr723 and N(delta2)H(2) of Asp722.	Hydrogen	123-131	cytokine like 1	Homo sapiens	92-95
12437383-13	2002	In the presence of top 1, after CPT conversion to the carboxylate form and DNA nicking, the C17 hydroxyl makes a branching hydrogen bond with N1 and N3 of guanine while the C20 carboxyl makes two hydrogen bonds with the NH of Tyr723 and N(delta2)H(2) of Asp722.	Hydrogen	196-204	cytokine like 1	Homo sapiens	92-95
12228253-6	2002	The higher affinity of SHBG for estradiol derivatives with a halogen atom at C-2 is due to either enhanced hydrogen bonding between the hydroxyl at C-3 and Asp(65) (2-fluoroestradiol) or accommodation of the functional group at C-2 (2-bromoestradiol), rather than an interaction with Asn(82).	Hydrogen	107-115	complement C2	Homo sapiens	77-80
30119179-10	2018	And the underlying mechanism of antisenescence effects of hydrogen in BMSCs was via the ROS/p53/p21 signaling pathway.	Hydrogen	58-66	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	92-95
28978264-4	2018	Thermodynamic analysis and molecular modeling suggest that hydrophobic interaction and hydrogen bonding interaction are the main binding force in stabilizing the flavonol-FTO complex.	Hydrogen	87-95	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	171-174
12270612-1	2002	Cisplatin (cis-DDP) is subject to nucleophilic displacement of chloride in water, forming aquated species, subsequently liberating hydrogen ion(s) with increasing pH.	Hydrogen	131-139	translocase of inner mitochondrial membrane 8A	Homo sapiens	15-18
30350551-0	2018	Sub-1.5 nm Ultrathin CoP Nanosheet Aerogel: Efficient Electrocatalyst for Hydrogen Evolution Reaction at All pH Values.	Hydrogen	74-82	caspase recruitment domain family member 16	Homo sapiens	21-24
12359317-0	2002	Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats.	Hydrogen	67-69	acetylcholinesterase	Rattus norvegicus	119-139
30568762-5	2018	Furthermore, docking of 6e/6h into the ATR structure active site revealed that the N1 and N8 atoms in the naphthyridine ring and the hybrid atom in the oxadiazole ring are involved in hydrogen bonding with Val170, Glu168 and Tyr155.	Hydrogen	184-192	serine/threonine-protein kinase ATR	Cricetulus griseus	39-42
12236710-8	2002	The net results come from the slow dissociation of the O2 ligand in the reconstituted myoglobin, koff = 0.11 s-1, because of the formation of strong hydrogen bond between His64 and negatively charged dioxygen.	Hydrogen	149-157	myoglobin	Homo sapiens	86-95
30009517-0	2018	Structure of the CoI Intermediate of a Cobalt Pentapyridyl Catalyst for Hydrogen Evolution Revealed by Time-Resolved X-ray Spectroscopy.	Hydrogen	72-80	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	17-20
12469953-8	2002	The photodecoloration of RR2 was found to co-occur with photodechlorination and was followed by photodesulfonation at a later stage in which the mineralized end products, including hydrogen, chloride, and sulphorate ions, were detected in approximately stoichiometric amounts.	Hydrogen	181-189	ribonucleotide reductase regulatory subunit M2	Homo sapiens	25-28
29964048-3	2018	In this work, we use a unique approach based on millisecond hydrogen-deuterium exchange mass spectrometry to identify dynamic modes linked to individual catalytic processes in the antibiotic resistance enzyme TEM-1 beta-lactamase.	Hydrogen	60-68	CD248 molecule	Homo sapiens	209-214
12169661-1	2002	Na+/H+ exchanger regulatory factor (NHERF)-1 and NHERF-2, two structurally related protein adapters containing tandem PSD-95/Discs large/ZO-1 (PDZ) domains, were identified as essential factors for protein kinase A-mediated inhibition of the sodium-hydrogen exchanger, NHE3.	Hydrogen	249-257	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	36-44
29753648-7	2018	Using 1H-nuclear magnetic resonance metabolomic analysis, we found that the content of NAD and NMN were increased in the VTA of cocaine-conditioned mice; moreover, the expression of SIRT1 was also upregulated.	Hydrogen	6-8	sirtuin 1	Mus musculus	182-187
12139936-0	2002	The membrane-bound conformation of alpha-lactalbumin studied by NMR-monitored 1H exchange.	Hydrogen	78-80	lactalbumin alpha	Bos taurus	35-52
12139936-1	2002	The interaction of bovine alpha-lactalbumin (BLA) with negatively charged phospholipid bilayers was studied by NMR monitored 1H exchange to characterize the conformational transition that enables a water-soluble protein to associate with and partially insert into a membrane.	Hydrogen	125-127	lactalbumin alpha	Bos taurus	26-43
30070481-2	2018	However, among the possible extra-framework aluminum (EFAL) species in dealuminated zeolites such as Al3+, Al(OH)2+, Al(OH)2+, AlO+, AlOOH, and Al(OH)3, the presence of tri-coordinated EFAL-Al3+ species, which exhibit large quadrupolar effect due to the lack of hydrogen-bonding species, was normally undetectable by conventional one- and two-dimensional 1H and/or 27Al solid-state nuclear magnetic resonance (SSNMR) techniques.	Hydrogen	262-270	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	169-172
12203676-8	2002	Multiple consecutive hydrogen migrations in metastable 1(+*), as modeled by RRKM calculations on the G2(MP2) potential energy surface, explain the unusual deuterium kinetic isotope effects on the CO elimination.	Hydrogen	21-29	tryptase pseudogene 1	Homo sapiens	104-107
30070481-2	2018	However, among the possible extra-framework aluminum (EFAL) species in dealuminated zeolites such as Al3+, Al(OH)2+, Al(OH)2+, AlO+, AlOOH, and Al(OH)3, the presence of tri-coordinated EFAL-Al3+ species, which exhibit large quadrupolar effect due to the lack of hydrogen-bonding species, was normally undetectable by conventional one- and two-dimensional 1H and/or 27Al solid-state nuclear magnetic resonance (SSNMR) techniques.	Hydrogen	355-357	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	169-172
12102636-12	2002	Aromatic residues in this pocket may interact directly with substrates of rOAT3 through hydrogen bonds and pi-pi interactions.	Hydrogen	88-96	solute carrier family 22 member 8	Rattus norvegicus	74-79
30046793-0	2018	CdS p-n heterojunction co-boosting with Co3O4 and Ni-MOF-74 for photocatalytic hydrogen evolution.	Hydrogen	79-87	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
30046793-2	2018	The maximum amount of hydrogen evolution reaches about 581 mumol for 5 h over the Ni-MOF-74/CdS/Co3O4 (10 wt% Co) photocatalyst under visible light irradiation, which is 16.2 times higher than that over pure CdS.	Hydrogen	22-30	CDP-diacylglycerol synthase 1	Homo sapiens	92-95
30046793-2	2018	The maximum amount of hydrogen evolution reaches about 581 mumol for 5 h over the Ni-MOF-74/CdS/Co3O4 (10 wt% Co) photocatalyst under visible light irradiation, which is 16.2 times higher than that over pure CdS.	Hydrogen	22-30	CDP-diacylglycerol synthase 1	Homo sapiens	208-211
12148809-3	2002	The presence of intramolecular flip-flop hydrogen bonding in 1 was confirmed both with calculations and in ND3-exchange experiments.	Hydrogen	41-49	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	107-110
12074663-2	2002	Crystal structures of both TnbU and the charge-transfer complex of TnbU-hydrogen cyananilate possess complementary double hydrogen bonds through uracil moieties and pi-stacking dimer structures between TTF skeletons.	Hydrogen	72-80	ras homolog family member H	Homo sapiens	202-205
29847705-5	2018	Furthermore, the photocatalytic system exhibits sustained H2 production rate for 12 h with sequential turnover numbers surpassing 4x103 , 3x103 , and 2x103 for Co-Ni/CdS NRs, Ni/CdS NRs, and CoCl2 /CdS NRs, respectively.	Hydrogen	58-60	CDP-diacylglycerol synthase 1	Homo sapiens	166-169
29847705-5	2018	Furthermore, the photocatalytic system exhibits sustained H2 production rate for 12 h with sequential turnover numbers surpassing 4x103 , 3x103 , and 2x103 for Co-Ni/CdS NRs, Ni/CdS NRs, and CoCl2 /CdS NRs, respectively.	Hydrogen	58-60	CDP-diacylglycerol synthase 1	Homo sapiens	178-181
12054929-6	2002	Clearly, DOIS recognizes the G-6-P substrate through specific hydrogen-bonding interactions, i.e., through a hydrogen-donating group for C-2 and an accepting group for C-3 of the substrate.	Hydrogen	62-70	complement C2	Homo sapiens	137-140
12054929-6	2002	Clearly, DOIS recognizes the G-6-P substrate through specific hydrogen-bonding interactions, i.e., through a hydrogen-donating group for C-2 and an accepting group for C-3 of the substrate.	Hydrogen	109-117	complement C2	Homo sapiens	137-140
29847705-5	2018	Furthermore, the photocatalytic system exhibits sustained H2 production rate for 12 h with sequential turnover numbers surpassing 4x103 , 3x103 , and 2x103 for Co-Ni/CdS NRs, Ni/CdS NRs, and CoCl2 /CdS NRs, respectively.	Hydrogen	58-60	CDP-diacylglycerol synthase 1	Homo sapiens	178-181
29852353-8	2018	Besides, H2 down-regulated the expression of NIBPL, SMC3, SMC5 and SMC6, and also reduced the expression of Cyclin D1, CDK4 and CDK6.	Hydrogen	9-11	structural maintenance of chromosomes 6	Homo sapiens	67-71
30033466-4	2018	In this study, we computed the electronic and vibrational (hyper)polarizabilities of ten hydrogen-bonded molecular complexes employing the MP2, CCSD and CCSD(T) methods combined with the aug-cc-pVTZ basis set.	Hydrogen	89-97	tryptase pseudogene 1	Homo sapiens	139-142
12067244-3	2002	The PHB-Cbl formed was compared with a synthetic standard verified by LC/MS and 1H NMR and corresponds to phosphate adducts formed from the pyridyloxobutylating species from NNK and from the pyridylhydroxybutylating species from NNAL, NNK being to a large extent converted to NNAL in vivo.	Hydrogen	80-82	Casitas B-lineage lymphoma	Mus musculus	8-11
12153046-0	2002	1H, 13C and 15N backbone resonance assignment of the peptidyl-prolyl cis-trans isomerase Pin1.	Hydrogen	0-2	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	89-93
12153047-0	2002	1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex.	Hydrogen	0-2	LIM domain binding 1	Homo sapiens	61-65
12018485-0	2002	1H, 13C and 15N resonance assignments of the C-terminal domain of human lamin A/C.	Hydrogen	0-2	lamin A/C	Homo sapiens	72-81
22175854-8	2012	In contrast, damage removal by hOGG1 is sensitive  to both hydrogen bonding groups and nucleobase shape.	Hydrogen	59-67	8-oxoguanine DNA glycosylase	Homo sapiens	31-36
22175651-1	2012	Charge-assisted hydrogen bonds (CAHBs) of N-H   Cl, N-H   Br, and P-H   Cl type were investigated using advanced computational approach (MP2/aug-cc-pVTZ level of theory).	Hydrogen	16-24	tryptase pseudogene 1	Homo sapiens	137-140
30108516-0	2018	Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats.	Hydrogen	14-22	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	111-114
22122932-7	2012	The explanation for so high ACFs can be found in the extremely efficient retention mechanisms that the DeA-based SUPRAS provides for CPAHs (i.e. formation of hydrogen bonds and hydrophobic interactions), and the high number of binding sites that it contains (i.e. the concentration of biosurfactant in the SUPRAS was 0.56 mg muL(-1)).	Hydrogen	158-166	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	325-331
23285125-13	2012	This is confirmed by the simulations of hNaa50p/AcCoA/EEE and hNaa10p/AcCoA/MLG, where these hydrogen bonds are still observed.	Hydrogen	93-101	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	40-47
11872165-8	2002	However, the residues have weak interactions with the flavin ring due to the loss of some of the important hydrogen bonds with the flavin ring found in MCAD.	Hydrogen	107-115	acyl-CoA dehydrogenase medium chain	Rattus norvegicus	152-156
23152789-9	2012	Cavity analyses suggest the presence of a reasonably sized bifurcated cavity in antithrombin that facilitates a firm "hand-shake" with H/HS, but with thrombin, a weaker "high-five".	Hydrogen	137-139	serpin family C member 1	Homo sapiens	80-92
30108516-9	2018	Finally, as a pivotal transcription factor in reactive oxygen species (ROS)-apoptosis signaling pathway, the expression and phosphorylation of p53 were significantly reduced by H2 treatment in this rat model and H9c2 cells (p &lt; 0.05 or p &lt; 0.01).	Hydrogen	177-179	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	143-146
11862551-6	2002	Finally, 1H-15N HSQC NMR spectroscopy was used to establish that these oxyanions, including the arsenate substrate, exert their stabilizing effect on ArsC through binding with residues located within a C-X5-R sequence motif, characteristic for phosphotyrosine phosphatases.	Hydrogen	9-11	Arsenate reductase	Staphylococcus aureus	150-154
30108516-10	2018	Conclusion: As a safe antioxidant, molecular hydrogen mitigates the progression of CHF via inhibiting apoptosis modulated by p53.	Hydrogen	45-53	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	125-128
29869845-7	2018	The key interactions were found to be a salt bridge and a hydrogen bond formed between (R)-PFI-2"s NH2+ group and SETD7"s Asp256 and His252 residue, respectively.	Hydrogen	58-66	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	114-119
12362385-0	2002	Hydrogen/deuterium exchange of myoglobin ions in a linear quadrupole ion trap.	Hydrogen	0-8	myoglobin	Homo sapiens	31-40
22470497-10	2012	We further propose a third binding site on KLC1 which involves a stretch of polar residues along the inter-TPR loops that may form a network of hydrogen bonds to JIP3 and JIP4.	Hydrogen	144-152	mitogen-activated protein kinase 8 interacting protein 3	Homo sapiens	162-166
22470497-10	2012	We further propose a third binding site on KLC1 which involves a stretch of polar residues along the inter-TPR loops that may form a network of hydrogen bonds to JIP3 and JIP4.	Hydrogen	144-152	sperm associated antigen 9	Homo sapiens	171-175
12362385-1	2002	The hydrogen/deuterium (H/D) exchange of gas-phase ions of holo- and apo-myoglobin has been studied by confining the ions in a linear quadrupole ion trap with D(2)O or CD(3)OD at a pressure of several mTorr.	Hydrogen	4-12	myoglobin	Homo sapiens	73-82
29803677-4	2018	The absorbance change in 614 nm was positively correlated with the generated hydrogen ions in the reaction catalyzed by ADK.	Hydrogen	77-85	adenosine kinase	Bombyx mori	120-123
12362385-5	2002	Despite this, both holo-myoglobin and apo-myoglobin in charge states +8 to +14 are found to exchange nearly the same number of hydrogens (ca.	Hydrogen	127-136	myoglobin	Homo sapiens	24-33
12362385-5	2002	Despite this, both holo-myoglobin and apo-myoglobin in charge states +8 to +14 are found to exchange nearly the same number of hydrogens (ca.	Hydrogen	127-136	myoglobin	Homo sapiens	42-51
22178826-12	2011	CONCLUSION: Silencing of LASS2 can promote invasion of prostate cancer cells in vitro through the increase of the V-ATPases activity, extracellular hydrogen ion concentration and in turn the activation of secreted MMP-2, indicating that LASS2 is a novel tumor metastasis suppressor gene.	Hydrogen	148-156	ceramide synthase 2	Homo sapiens	25-30
22199919-3	2011	In the crystal, mol-ecules are linked by N-H O hydrogen bonds, forming C(4) chains propagating along the b-axis direction.	Hydrogen	47-55	complement C4A (Rodgers blood group)	Homo sapiens	71-75
22199924-5	2011	The carbonyl O atom bonded to the thia-zole ring is involved in two C-H O hydrogen-bond inter-actions forming centrosymmetric dimers; the ten- and six-membered rings resulting from these inter-actions have R(2) (2)(10) and R(1) (2)(6) motifs, respectively.	Hydrogen	74-82	CD1b molecule	Homo sapiens	223-227
21978376-0	2011	Electronic properties of hydrogen-bonded complexes of benzene(HCN)(1-4): comparison with benzene(H2O)(1-4).	Hydrogen	25-33	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	62-65
11743736-4	2001	However, in contrast to our previous description of this mobility, which included rupture of the Watson-Crick hydrogen bonds and formation of non-Watson-Crick hydrogen bonds, the MD simulation indicated that the G*4-C17 pair moves continuously along a trajectory roughly perpendicular to the local helix axis, with retention of all three Watson-Crick hydrogen bonds.	Hydrogen	110-118	cytokine like 1	Homo sapiens	216-219
11743736-4	2001	However, in contrast to our previous description of this mobility, which included rupture of the Watson-Crick hydrogen bonds and formation of non-Watson-Crick hydrogen bonds, the MD simulation indicated that the G*4-C17 pair moves continuously along a trajectory roughly perpendicular to the local helix axis, with retention of all three Watson-Crick hydrogen bonds.	Hydrogen	159-167	cytokine like 1	Homo sapiens	216-219
11743736-4	2001	However, in contrast to our previous description of this mobility, which included rupture of the Watson-Crick hydrogen bonds and formation of non-Watson-Crick hydrogen bonds, the MD simulation indicated that the G*4-C17 pair moves continuously along a trajectory roughly perpendicular to the local helix axis, with retention of all three Watson-Crick hydrogen bonds.	Hydrogen	159-167	cytokine like 1	Homo sapiens	216-219
29884064-6	2018	However, the inclusion of hydrogen seems to have a substantial effect as it diffuses rapidly and can easily enter occupied cages, which reduces the barriers of diffusion for the gas molecules that co-occupy a cage with hydrogen.	Hydrogen	26-34	gastrin	Homo sapiens	178-181
11824760-0	2001	1H, 15N and 13C assignments of FLIN2, an intramolecular LMO2:ldb1 complex.	Hydrogen	0-2	LIM domain binding 1	Homo sapiens	61-65
11824761-0	2001	Assignments of the 1H,13C, and 15N resonances of the substrate-binding SSD domain from Lon protease.	Hydrogen	19-21	lon peptidase 1, mitochondrial	Homo sapiens	87-99
29884064-6	2018	However, the inclusion of hydrogen seems to have a substantial effect as it diffuses rapidly and can easily enter occupied cages, which reduces the barriers of diffusion for the gas molecules that co-occupy a cage with hydrogen.	Hydrogen	219-227	gastrin	Homo sapiens	178-181
29532858-8	2018	All of the results indicated that hydrogen decreased the levels of reactive oxygen species, 8-iso-prostaglandin F2alpha and malondialdehyde, and promoted the UVB exposure-induced expression of PI3K, Akt, Nrf2 and heme oxygenase-1 in HaCaT cells.	Hydrogen	34-42	heme oxygenase 1	Homo sapiens	213-229
12164388-2	2001	Significant correlations are obtained between the 5HT2B receptor antagonist affinity and the hydrophobic, steric, electronic, hydrogen bond acceptor and some indicator variables of substituents.	Hydrogen	126-134	5-hydroxytryptamine receptor 2B	Rattus norvegicus	50-55
21983208-5	2011	Western blot analysis showed that phospho-ser727-STAT3 significantly increased from 8 to 48 h after nonlethal ischemia, while it increased only for 1h after lethal ischemia and returned to the baseline within 24h.	Hydrogen	148-150	signal transducer and activator of transcription 3	Rattus norvegicus	49-54
29532858-10	2018	Therefore, hydrogen effectively protects cells from UVB radiation-induced oxidative stress by inhibiting Nrf2/HO-1 activation through the PI3K/Akt signaling pathway.	Hydrogen	11-19	heme oxygenase 1	Homo sapiens	110-114
11714264-6	2001	A novel hydrogen exchange labeling-quench strategy, employing a high-affinity ligand to displace Cdc42 from WASP, was used to examine the amide exchange from the Cdc42-bound state of GBD-C.	Hydrogen	8-16	WASP actin nucleation promoting factor	Homo sapiens	108-112
29505789-4	2018	Synaptically driven spontaneous action potential (AP) firing was significantly reduced by the TLR3 specific activator, poly I:C, in a concentration-dependent manner following both short (5 min) and long exposures (1h) in rat hippocampal cultures.	Hydrogen	214-216	toll-like receptor 3	Rattus norvegicus	94-98
21982337-5	2011	Docking study of the compound 3b into the active site of the topoisomerase II DNA-gyrase enzymes revealed a similar binding mode to ciprofloxacin with additional classical and nonclassical hydrogen bonds.	Hydrogen	189-197	DNA topoisomerase II alpha	Homo sapiens	78-88
29741363-0	2018	Designing Hybrid NiP2/NiO Nanorod Arrays for Efficient Alkaline Hydrogen Evolution.	Hydrogen	64-72	BCL2 interacting protein 2	Homo sapiens	17-21
21910503-1	2011	We report on the structure, uniaxial orientation, and photoluminescent properties of CdS nanorods that form stable nanocomposites with smectic C hydrogen-bonded polymers from the family of poly(4-(n-acryloyloxyalkoxy)benzoic acids.	Hydrogen	145-153	CDP-diacylglycerol synthase 1	Homo sapiens	85-88
11555638-6	2001	Of most interest is the rearrangement of hydrogen bonding around the breach region that accompanies the stressed to relaxed transition, in particular the formation of a side chain hydrogen bond between the threonine at P14 and an adjacent tyrosine on strand 2 of beta-sheet B in relaxed PAI-2.	Hydrogen	41-49	serpin family B member 2	Homo sapiens	287-292
11555638-6	2001	Of most interest is the rearrangement of hydrogen bonding around the breach region that accompanies the stressed to relaxed transition, in particular the formation of a side chain hydrogen bond between the threonine at P14 and an adjacent tyrosine on strand 2 of beta-sheet B in relaxed PAI-2.	Hydrogen	180-188	serpin family B member 2	Homo sapiens	287-292
29513263-0	2018	Wrinkle-free atomically thin CdS nanosheets for photocatalytic hydrogen evolution.	Hydrogen	63-71	CDP-diacylglycerol synthase 1	Homo sapiens	29-32
11668563-0	2001	Combined Effects of Metal and Ligand Capable of Accepting a Proton or Hydrogen Bond Catalyze Anti-Markovnikov Hydration of Terminal Alkynes The support of San Diego State University is acknowledged.	Hydrogen	70-78	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	155-158
21600698-5	2011	LPS-stimulated TNF-alpha mRNA decreased significantly immediately post-stress and partially recovered at 1h post-stress, whereas LPS-stimulated IL-6 mRNA exhibited a significant change across time, with an increase immediately after stress and a decrease 1h after stress.	Hydrogen	105-107	interferon regulatory factor 6	Homo sapiens	0-3
21600698-5	2011	LPS-stimulated TNF-alpha mRNA decreased significantly immediately post-stress and partially recovered at 1h post-stress, whereas LPS-stimulated IL-6 mRNA exhibited a significant change across time, with an increase immediately after stress and a decrease 1h after stress.	Hydrogen	255-257	interferon regulatory factor 6	Homo sapiens	0-3
21600698-5	2011	LPS-stimulated TNF-alpha mRNA decreased significantly immediately post-stress and partially recovered at 1h post-stress, whereas LPS-stimulated IL-6 mRNA exhibited a significant change across time, with an increase immediately after stress and a decrease 1h after stress.	Hydrogen	255-257	interferon regulatory factor 6	Homo sapiens	129-132
21893069-6	2011	In GluK2, NDH pushes and rotates the side chain of Asn690 (substituted for Ser706 in GluK1) and disrupts an interdomain hydrogen bond with Glu409.	Hydrogen	120-128	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	3-8
11571157-4	2001	In addition, two of them (Am-H and Ex-18.2) could grow on sulfur lithoautrotrophically using hydrogen as the electron donor.	Hydrogen	93-101	anti-Mullerian hormone	Homo sapiens	26-30
29746104-9	2018	Zn/KCC-1, on the other hand, showed no such peak, indicating associative methanation pathways where a hydrogen molecule interacts with an O atom in CO2 to form COads and OH.	Hydrogen	102-110	solute carrier family 12 member 4	Homo sapiens	3-8
11511226-1	2001	Thermal decomposition of monochlorogallane, [H2GaCl]n, at ambient temperatures releases H2 and results in the formation of gallium(I) species, including the new compound Ga[GaHCl3], which has been characterized crystallographically at 100 K (monoclinic P2(1)/n, a = 5.730(1), b = 6.787(1), c = 14.508(1) A, beta = 97.902(5) degrees ) and by its Raman spectrum.	Hydrogen	45-47	H3 histone pseudogene 16	Homo sapiens	253-258
29453104-0	2018	Controlling shape anisotropy of hexagonal CdS for highly stable and efficient photocatalytic H2 evolution and photoelectrochemical water splitting.	Hydrogen	93-95	CDP-diacylglycerol synthase 1	Homo sapiens	42-45
11468348-2	2001	In the structure, four out of the six hypervariable loops of the Fab (complementarity determining regions [CDRs] L1, H1, H2, and H3) are involved in peptide association through hydrogen bonding, salt bridge formation, and hydrophobic interactions.	Hydrogen	177-185	FA complementation group B	Homo sapiens	65-68
21893069-6	2011	In GluK2, NDH pushes and rotates the side chain of Asn690 (substituted for Ser706 in GluK1) and disrupts an interdomain hydrogen bond with Glu409.	Hydrogen	120-128	GLIS family zinc finger 3	Homo sapiens	10-13
29453104-1	2018	Photocorrosion and low solar conversion efficiency hindered widely applications of CdS in photocatalytic (PC) H2 evolution and photoelectrochemical (PEC) water splitting.	Hydrogen	110-112	CDP-diacylglycerol synthase 1	Homo sapiens	83-86
29453104-2	2018	Hence, this work reports the shape anisotropy of hexagonal CdS possesses highly stable and efficient PC H2 evolution and PEC water splitting by simply mixed diethylenetriamine (DETA) and deionized water (DIW) solvothermal.	Hydrogen	104-106	CDP-diacylglycerol synthase 1	Homo sapiens	59-62
11373289-3	2001	Toward determining the structural basis for the selective receptor specificity of CCL20, we have determined its three-dimensional structure by 1H NMR spectroscopy.	Hydrogen	143-145	chemokine (C-C motif) ligand 20	Mus musculus	82-87
21888321-3	2011	A contribution of this interaction to the stabilization of the transition state for the transfer of a hydrogen atom from the adjacent terminal C(1)H(2)(OH) group to cysteine 433 was determined by ab initio HF, MP2, and CCSD(T) calculations with the aug-cc-pvDZ basis set for the corresponding methane/benzene, methanol/phenol, and glycerol radical/phenol subsystems.	Hydrogen	102-110	tryptase pseudogene 1	Homo sapiens	210-213
29453104-4	2018	The CdS-Nanorod yields optimal 5.4 mmol/g/h PC H2 production and photocurrent density 2.63 mA/cm2 at open circuit potential (OCP).	Hydrogen	47-49	CDP-diacylglycerol synthase 1	Homo sapiens	4-7
29453104-6	2018	Moreover, hexagonal CdS-Nanorod shows long-term PC H2 production and highly stable photocurrent density.	Hydrogen	51-53	CDP-diacylglycerol synthase 1	Homo sapiens	20-23
29453104-7	2018	As compared with CdS-Nanosphere, the hexagonal CdS-Nanorod exhibits 27 times and 19.2 times in H2 production and photocurrent density, respectively.	Hydrogen	95-97	CDP-diacylglycerol synthase 1	Homo sapiens	47-50
11470437-10	2001	An unprecedented 3 residue shift in registration between beta strands B2 and A2 in the C-terminal beta barrel and hydrogen bonds involving Glu154 provide new insight into conformational changes accompanying zymogen activation, TF binding, and enzymatic competence.	Hydrogen	114-122	coagulation factor III, tissue factor	Homo sapiens	227-229
26598144-13	2011	The jun-cc-pV(T+d)Z basis set is very useful for MP2-F12 calculations of barrier heights and hydrogen bond strengths.	Hydrogen	93-101	tryptase pseudogene 1	Homo sapiens	49-52
29453104-10	2018	The possible mechanism of PC H2 evolution and PEC water spiltting are proposed for CdS-Nanorod.	Hydrogen	29-31	CDP-diacylglycerol synthase 1	Homo sapiens	83-86
29762534-6	2018	The results of calculations show that the tetrel bond is sometimes accompanied by the Z-H   C hydrogen bond or even sometimes the ZFH3-B complexes are linked only by the hydrogen bond interaction.	Hydrogen	170-178	zinc finger homeobox 3	Homo sapiens	130-134
21860867-3	2011	Quantum chemical calculations at the ab initio HF/MP2 theoretical level were employed to estimate the maximum uptake of H(2) molecules per metallic centre.	Hydrogen	120-124	tryptase pseudogene 1	Homo sapiens	50-53
21703224-5	2011	At pH 6.9, (1)H-NMR spectrum of deoxy-Hb in the presence of L35 and IHP showed a marker of the T-quaternary structure (the T-marker) at 14ppm, originated from inter- dimeric alpha(1)beta(2)- (or alpha(2)beta(1)-) hydrogen-bonds, and hyperfine-shifted (hfs) signals around 15-25ppm, caused by high-spin heme-Fe(II)s. Upon addition of O(2), the hfs signals disappeared, reflecting that the heme-Fe(II)s are ligated with O(2), but the T-marker signals still remained, although slightly shifted and broadened, under the partial pressure of O(2) (P(O2)) of 760mmHg.	Hydrogen	213-221	ribosomal protein L35	Homo sapiens	60-63
11419947-9	2001	Thus, the role of LA is to hold Glc by hydrogen bonding with the O-1 hydroxyl group in the acceptor-binding site on beta4Gal-T1, while the N-acetyl group-binding pocket in beta4Gal-T1 adjusts to maximize the interactions with the Glc molecule.	Hydrogen	39-47	beta-1,4-galactosyltransferase 1	Homo sapiens	116-127
29534936-4	2018	In addition, molecular docking simulation showed that several key hydrogen bonding interactions were formed for compounds 12d, 20a and 20c in the PI3Kdelta pocket, which might explain their potent PI3Kdelta inhibition.	Hydrogen	66-74	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	146-155
11401551-0	2001	Interaction of yeast iso-1-cytochrome c with cytochrome c peroxidase investigated by [15N, 1H] heteronuclear NMR spectroscopy.	Hydrogen	91-93	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	21-26
11373616-4	2001	Numerous point mutations of the LDLR that result in the genetic disease familial hypercholesterolemia (FH) alter side chains that form conserved packing and hydrogen bonding interactions in the interior and between propeller blades.	Hydrogen	157-165	low density lipoprotein receptor	Homo sapiens	32-36
11373616-4	2001	Numerous point mutations of the LDLR that result in the genetic disease familial hypercholesterolemia (FH) alter side chains that form conserved packing and hydrogen bonding interactions in the interior and between propeller blades.	Hydrogen	157-165	low density lipoprotein receptor	Homo sapiens	103-105
21188560-0	2011	Backbone 1H, 15N, and 13C resonance assignments for the NOXO1beta PX domain.	Hydrogen	9-11	NADPH oxidase organizer 1	Homo sapiens	56-61
21298373-0	2011	Backbone and side-chain 1H, 15N and 13C resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1.	Hydrogen	24-26	ubiquitin C-terminal hydrolase L1	Homo sapiens	80-119
21298565-0	2011	1H, 13C and 15N backbone and side-chain chemical shift assignment of the Fyn SH2 domain and its complex with a phosphotyrosine peptide.	Hydrogen	0-2	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	73-76
29534936-4	2018	In addition, molecular docking simulation showed that several key hydrogen bonding interactions were formed for compounds 12d, 20a and 20c in the PI3Kdelta pocket, which might explain their potent PI3Kdelta inhibition.	Hydrogen	66-74	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	197-206
11356255-3	2001	Stimulation of BAEC with recombinant bovine tumor necrosis factor alpha (rbTNF-alpha) resulted in protein expression of VCAM-1 on less than 5% of all cultured BAECs at 1h post-stimulation, followed by a significant increase at 3h that was maintained until 48h when the proportion of VCAM-1 positive (+) cells decreased significantly, but not to baseline proportions.	Hydrogen	168-170	tumor necrosis factor	Bos taurus	44-71
29426722-4	2018	Application of copper slightly enhanced hydrogen production at low concentration and resulted in the hydrogen yield of 36.0 mLH2/gCarboinitial with 10 mg/L copper supplementation as compared to 24.2 mLH2/gCarboinitial in control.	Hydrogen	101-109	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	124-128
11304176-0	2001	1H NMR study of protected and unprotected kainoid amino acids: facile assignment of C-4 stereochemistry.	Hydrogen	0-2	complement C4A (Rodgers blood group)	Homo sapiens	84-87
21875153-0	2011	Energetics of hydrogen bond switch, residue burial and cavity analysis reveals molecular basis of improved heparin binding to antithrombin.	Hydrogen	14-22	serpin family C member 1	Homo sapiens	126-138
21875153-4	2011	Crystal structures and site directed mutagenesis studies have mapped the heparin binding site in ATIII, however the hydrogen bond switch and energetics of interaction during the course of heparin dependent conformational change remains largely unclear.	Hydrogen	116-124	serpin family C member 1	Homo sapiens	97-102
29597169-4	2018	Compound (1h) was identified as a hit candidate exhibiting MIC of 0.04 mug mL-1, closer to the MIC value of Isoniazid (0.02 mug mL-1), a commercially available drug for the treatment of tuberculosis.	Hydrogen	10-12	L1 cell adhesion molecule	Mus musculus	75-79
21875153-5	2011	An analysis of heparin bound conformational states of ATIII using PEARLS software showed that in heparin bound intermediate state, Arg 47 and Arg 13 residues make hydrogen bonds with heparin but in the activated conformation Lys 11 and Lys 114 have more hydrogen bond interactions.	Hydrogen	163-171	serpin family C member 1	Homo sapiens	54-59
21875153-5	2011	An analysis of heparin bound conformational states of ATIII using PEARLS software showed that in heparin bound intermediate state, Arg 47 and Arg 13 residues make hydrogen bonds with heparin but in the activated conformation Lys 11 and Lys 114 have more hydrogen bond interactions.	Hydrogen	254-262	serpin family C member 1	Homo sapiens	54-59
21875153-6	2011	In the protease bound-antithrombin-pentasaccharide complex Lys 114, Pro 12 and Lys 125 form important hydrogen bonding interactions.	Hydrogen	102-110	serpin family C member 1	Homo sapiens	22-34
11121422-0	2001	Disruption of an active site hydrogen bond converts human heme oxygenase-1 into a peroxidase.	Hydrogen	29-37	heme oxygenase 1	Homo sapiens	58-74
11121422-1	2001	The crystal structure of heme oxygenase-1 suggests that Asp-140 may participate in a hydrogen bonding network involving ligands coordinated to the heme iron atom.	Hydrogen	85-93	heme oxygenase 1	Homo sapiens	25-41
11354671-5	2001	The ligand-induced changes in interhelical hydrogen bonding patterns of the 5-HT1A receptor were followed by rigid body movements of TMH2, 4 and 6 relative to each other and to the other TMHs, which may reflect the structural conversion into an active receptor structure.	Hydrogen	43-51	5-hydroxytryptamine receptor 1A	Homo sapiens	76-91
29597169-4	2018	Compound (1h) was identified as a hit candidate exhibiting MIC of 0.04 mug mL-1, closer to the MIC value of Isoniazid (0.02 mug mL-1), a commercially available drug for the treatment of tuberculosis.	Hydrogen	10-12	L1 cell adhesion molecule	Mus musculus	128-132
11349812-5	2001	The results show that, at least for the properties of the hydrogen-bonded systems studied in this work, the B3LYP/6-31G** calculations give better results than the HF and MP2 calculations with the same basis set.	Hydrogen	58-66	tryptase pseudogene 1	Homo sapiens	171-174
29670348-8	2018	During the protein-loading process, the H2-TNTs not only enabled rapid protein adsorption, but also decreased the rate of protein elution compared with that of the air-TNTs.	Hydrogen	40-42	troponin T1, slow skeletal type	Homo sapiens	43-47
11258943-6	2001	Modeling suggests that Asp in position 306 prevents the TF-induced stimulation of FVIIa by disrupting essential intermolecular hydrogen bonds.	Hydrogen	127-135	coagulation factor III, tissue factor	Homo sapiens	56-58
29670348-8	2018	During the protein-loading process, the H2-TNTs not only enabled rapid protein adsorption, but also decreased the rate of protein elution compared with that of the air-TNTs.	Hydrogen	40-42	troponin T1, slow skeletal type	Homo sapiens	168-172
29067546-0	2018	1H, 13C and 15N chemical shift assignment of lissencephaly-1 homology (LisH) domain homodimer of human two-hybrid-associated protein 1 with RanBPM (Twa1).	Hydrogen	0-2	GID complex subunit 8 homolog	Homo sapiens	148-152
11456868-9	2001	Analysis of the bonding shows that methyl is bound more strongly than hydrogen over the Mo atom because the C 2p orbital has better overlap with the Mo d(z)2 orbital than the hydrogen 1s.	Hydrogen	70-78	complement C2	Homo sapiens	108-112
11456868-9	2001	Analysis of the bonding shows that methyl is bound more strongly than hydrogen over the Mo atom because the C 2p orbital has better overlap with the Mo d(z)2 orbital than the hydrogen 1s.	Hydrogen	175-183	complement C2	Homo sapiens	108-112
29086898-0	2018	1H, 13C, and 15N resonance assignments of FAS1-IV domain of human periostin, a component of extracellular matrix proteins.	Hydrogen	0-2	periostin	Homo sapiens	66-75
11341929-10	2001	The dehydrated mixture of sucrose and the LEA protein had higher glass transition temperatures and average strength of hydrogen bonding than dehydrated sucrose alone.	Hydrogen	119-127	late embryogenesis abundant protein D-34	Gossypium hirsutum	42-45
28436296-8	2018	The calculated thermodynamic parameters indicated that the hydrogen binding and vander Waals forces might play a major role in the interaction of these complexes with HSA and DNA.	Hydrogen	59-67	albumin	Bos taurus	167-170
11341929-11	2001	We suggest that LEA proteins may play a role together with sugars in the formation of a tight hydrogen bonding network in the dehydrating cytoplasm, thus conferring long-term stability.	Hydrogen	94-102	late embryogenesis abundant protein D-34	Gossypium hirsutum	16-19
11167330-2	2001	We report on a child with a metastasising medulloblastoma which was assessed by MR diffusion imaging and 1H MR spectroscopy (MRS).	Hydrogen	105-107	sterile alpha motif domain containing 11	Homo sapiens	108-123
11167330-2	2001	We report on a child with a metastasising medulloblastoma which was assessed by MR diffusion imaging and 1H MR spectroscopy (MRS).	Hydrogen	105-107	sterile alpha motif domain containing 11	Homo sapiens	125-128
29274874-5	2018	In particular, using Cu2+-DMPE-DTPA as a dopant, we observed a decrease of 1H T1 of sarcolipin by 2/3, allowing us to reduce the recycle delay up to 3 times.	Hydrogen	75-77	sarcolipin	Homo sapiens	84-94
11338780-0	2001	1H-NMR study of heavy metals complexation with hexakis(3,6-anhydro) tetrakis(2A,B,D,E-O-octyl) cyclomaltohexaose (OCT).	Hydrogen	0-2	plexin A2	Homo sapiens	114-117
29421509-3	2018	Molecular modeling studies performed by docking analysis were accomplished to predict that the active compounds and acarbose bind to the alpha-1,4-glucosidase enzyme catalytic site of MAL12 from the yeast Saccharomyces cerevisiae through stable hydrogen bonds primarily with the amino acid residues HIS279 and GLN322.	Hydrogen	245-253	alpha-glucosidase MAL12	Saccharomyces cerevisiae S288C	184-189
12836375-4	2001	SPG complexes with single stranded RNAs that have similar helix parameter to triple stranded SPG thorough hydrogen bonding and hydrophobic interaction.	Hydrogen	106-114	SPG16	Homo sapiens	0-3
12836375-4	2001	SPG complexes with single stranded RNAs that have similar helix parameter to triple stranded SPG thorough hydrogen bonding and hydrophobic interaction.	Hydrogen	106-114	SPG16	Homo sapiens	93-96
10952992-4	2000	Critical to family selective dimerization are intersubunit hydrogen bonds between basic region residue Tyr(307) and leucine zipper residue Glu(312), which are conserved in all CREB/CREM/ATF-1 family members.	Hydrogen	59-67	activating transcription factor 1	Homo sapiens	186-191
29473308-4	2018	As expected, the as-prepared mesoporous Fe-CoP HTPAs exhibit pronounced activity for water splitting owing to the advantages of abundant active reaction sites, short electron and ion pathways, and favorable hydrogen adsorption free energy (DeltaGH* ).	Hydrogen	207-215	caspase recruitment domain family member 16	Homo sapiens	43-46
11023791-0	2000	Dissecting the hydrogen exchange properties of insulin under amyloid fibril forming conditions: a site-specific investigation by mass spectrometry.	Hydrogen	15-23	insulin	Bos taurus	47-54
11023791-1	2000	We have examined the hydrogen exchange properties of bovine insulin under solution conditions that cause it to aggregate and eventually form amyloid fibrils.	Hydrogen	21-29	insulin	Bos taurus	60-67
10993252-0	2000	Detecting hydrogen bonding by NMR relaxation of the acceptor nuclei The formation of hydrogen bonds (HB) between phenol or N-methyltrifluoroacetamide and several acceptors (pyridine, carbonyl compounds, nitriles, amides) in CCl4 or CHCl3 been investigated through the analysis of NMR relaxation times (T1) of the heteronuclei (14N and 17O) directly involved in the HB interaction.	Hydrogen	10-18	C-C motif chemokine ligand 4	Homo sapiens	224-228
10924110-1	2000	The structure of cytochrome f includes an internal chain of five water molecules and six hydrogen-bonding side chains, which are conserved throughout the phylogenetic range of photosynthetic organisms from higher plants, algae, and cyanobacteria.	Hydrogen	89-97	cytochrome f	Chlamydomonas reinhardtii	17-29
10924110-2	2000	The in vivo electron transfer capability of Chlamydomonas reinhardtii cytochrome f was impaired in site-directed mutants of the conserved Asn and Gln residues that form hydrogen bonds with water molecules of the internal chain [Ponamarev, M. V., and Cramer, W. A.	Hydrogen	169-177	cytochrome f	Chlamydomonas reinhardtii	70-82
10937794-0	2000	Gas-phase H/D exchange reactions of polyamine complexes: (M + H)+, (M + alkali metal+), and (M + 2H)2+ Gas-phase hydrogen/deuterium exchange reactions between noncovalent polyamine complexes and D2O, CH3OD, or ND3 are undertaken in a quadrupole ion trap mass spectrometer.	Hydrogen	113-121	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	210-213
10920257-10	2000	The largest factor in the substantially low pK(a) of reduced flavin in DAO is probably the steric hindrance between the hydrogen atom of H-N(1)(flavin) and the hydrogen atom of H-N of Gly315, which becomes significant when a hydrogen is bound to N(1) of flavin.	Hydrogen	120-128	D-amino acid oxidase	Homo sapiens	71-74
10920257-10	2000	The largest factor in the substantially low pK(a) of reduced flavin in DAO is probably the steric hindrance between the hydrogen atom of H-N(1)(flavin) and the hydrogen atom of H-N of Gly315, which becomes significant when a hydrogen is bound to N(1) of flavin.	Hydrogen	160-168	D-amino acid oxidase	Homo sapiens	71-74
10920257-10	2000	The largest factor in the substantially low pK(a) of reduced flavin in DAO is probably the steric hindrance between the hydrogen atom of H-N(1)(flavin) and the hydrogen atom of H-N of Gly315, which becomes significant when a hydrogen is bound to N(1) of flavin.	Hydrogen	160-168	D-amino acid oxidase	Homo sapiens	71-74
11006941-1	2000	AIM: To study the effect of G-CSF therapy directly by MRI and 1H MRS in the lumbar and femoral bone marrow and differentiate between malignant bone marrow infiltration (MBMI) and reconversion of red marrow.	Hydrogen	62-64	colony stimulating factor 3	Homo sapiens	28-33
10850706-7	2000	Most contacts in the complex are between KIR and conserved HLA-C residues, but a hydrogen bond between Lys 44 of KIR2DL2 and Asn 80 of Cw3 confers the allotype specificity.	Hydrogen	81-89	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2	Homo sapiens	113-120
10756106-5	2000	This mutant, which is deficient in a hydrogen bond donor to the bacteriochlorophyll, showed an identical structure to the wild-type, implying that observed differences in interaction with other LH1 polypeptides must arise from cofactor binding.	Hydrogen	37-45	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	194-197
10794405-2	2000	The conformational properties of the peptide Ac-EPKRSVAFKKTKKEVKKVATPKK (CH-1), which belongs to the C-terminal domain of histone H1(o) (residues 99-121) and is adjacent to the central globular domain of the protein, were examined by means of 1H-NMR and circular dichroism.	Hydrogen	243-245	SUN domain containing ossification factor	Homo sapiens	73-77
10727222-1	2000	We have studied the effect of protium/deuterium substitution on different kinetics associated with the turnovers of cytochrome b(6)f complex in whole cells of Chlamydomonas reinhardtii.	Hydrogen	30-37	cytochrome b	Chlamydomonas reinhardtii	116-128
10716181-5	2000	Strand beta5 is hydrogen bonded to strands beta3 and beta4, both of which afford strong protection from solvent exchange.	Hydrogen	16-24	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	43-48
10623594-5	2000	It may derive from the modification of a conserved residue in proximity of the active site, possibly the tyrosine at hydrogen-bonding distance of TPQ C-4 ionized hydroxyl.	Hydrogen	117-125	complement C4A (Rodgers blood group)	Homo sapiens	150-153
10611262-1	2000	Thioredoxin is a small multifunctional protein which acts as a dithiol hydrogen donor for ribonucleotide reductase in DNA synthesis.	Hydrogen	71-79	thioredoxin	Homo sapiens	0-11
10857384-3	2000	The maximum hydrogen bond-forming capacity corrected for intra-molecular H-bonding (Hbc) and Lien"s QSAR model were used in this study.	Hydrogen	12-20	keratin 88, pseudogene	Homo sapiens	84-87
11256749-6	2000	The allotype specificity of KIR2DL2 for HLA-Cw3 is the result of a single hydrogen bond from Lys44 of the KIR to Asn80 of HLA-C as all other HLA-C residues that contact KIR are conserved.	Hydrogen	74-82	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2	Homo sapiens	28-35
10728864-2	2000	In order to confirm the existence of such a cooperative effect, we have determined experimentally the enthalpy changes occurring upon hydrogen bonding of NMA in CCl4 solution.	Hydrogen	134-142	C-C motif chemokine ligand 4	Homo sapiens	161-165
10677824-3	1999	We present a pulse sequence, H(CN)N(H), for alleviating this problem in hydrogen bonds of the type NdH...Na-CH, in which the donor Nd nitrogen is correlated with the corresponding non-exchangeable C-H proton associated with the acceptor Na nitrogen.	Hydrogen	72-80	GLIS family zinc finger 3	Homo sapiens	99-102
10510301-14	1999	The "hydrostatic versus osmotic pressure" approach probed the importance of water in aging, and also revealed that Asp-70 and Glu-197 are the major residues controlling both the dynamics and the structural organization of the water/hydrogen-bond network in the active-site gorge of BuChE.	Hydrogen	232-240	butyrylcholinesterase	Homo sapiens	282-287
21710636-5	2011	The analytic potential energy function produces the equilibrium hydrogen bond distances of the MP2/6-311+G** with BSSE correction within the error limits of 0.030 A for all the 20 dimers.	Hydrogen	64-72	tryptase pseudogene 1	Homo sapiens	95-98
21984268-6	2011	The hit interacted with human acrosin mainly through hydrophobic and hydrogen-bonding interactions, which provided a good starting structure for further optimization studies.	Hydrogen	69-77	acrosin	Homo sapiens	30-37
22059024-2	2011	The crystal structure is stabilized by inter-molecular N-H O hydrogen bonds which link the mol-ecules, forming C(4) chains running along the c axis.	Hydrogen	61-69	complement C4A (Rodgers blood group)	Homo sapiens	111-115
21544615-0	2011	H2 inhibits TNF-alpha-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor kappaB activation in endothelial cells.	Hydrogen	0-2	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	30-65
21880102-8	2011	Deuterium was completely exchanged with hydrogen at the substituted carbon atom (C-2) of the succinate adducts of n-alkanes, whereas it is retained in toluene-derived benzylsuccinate, regardless of the type of enzyme catalysing the fumarate addition reaction.	Hydrogen	40-48	complement C2	Homo sapiens	81-84
21717014-3	2011	Our strategy started from its five 2"-deoxyadenosine residues (A5, A9, A11, A12, and A15) in the loop based on the capability of the N7 atom to form hydrogen bonds in tertiary structures.	Hydrogen	149-157	DXS435E	Homo sapiens	71-74
21797204-2	2011	Since the C-5 hydrogen is acidic, under basic condition ionic liquids 1 and 2 were readily methylated with methyl iodide to afford chemically stable ionic liquids 7 and 8 at room temperature (88% and 82%, respectively).	Hydrogen	14-22	complement C5	Homo sapiens	10-13
21749107-2	2011	Reaction of the digermyne and distannyne with CpH gave the cyclopentadienyl anion, which is bound in a pi-fashion to a mononuclear group 14 element center, along with evolution of hydrogen gas.	Hydrogen	180-188	carboxypeptidase E	Homo sapiens	46-49
21638158-1	2011	The design, synthesis, and characterization of an unsymmetrical diamidato-dithiol ligand (H(4) 1, where the hydrogen atoms represent deprotonatable amide and thiol protons) and its cobalt(III) complex, a synthetic analogue of the cobalt-containing nitrile hydratase enzyme family, are reported.	Hydrogen	108-116	CDV3 homolog	Homo sapiens	82-96
21723254-5	2011	Hydrogen treatment inhibited LPS/IFNgamma-induced phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) and its downstream signaling molecules, p38 MAP kinase and JNK, as well as IkappaBalpha, but did not affect activation of NADPH oxidase and production of reactive oxygen species (ROS).	Hydrogen	0-8	mitogen-activated protein kinase kinase kinase 5	Mus musculus	69-105
21723254-5	2011	Hydrogen treatment inhibited LPS/IFNgamma-induced phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) and its downstream signaling molecules, p38 MAP kinase and JNK, as well as IkappaBalpha, but did not affect activation of NADPH oxidase and production of reactive oxygen species (ROS).	Hydrogen	0-8	mitogen-activated protein kinase kinase kinase 5	Mus musculus	107-111
21664342-4	2011	The cellular uptake of HOXA5-PTD-EGFP was detected in 1min and its transduction reached a maximum at 1h within cell lysates.	Hydrogen	101-103	homeobox A5	Homo sapiens	23-28
21553855-2	2011	Three products were observed from the reactions catalyzed by TIM: dihydroxyacetone phosphate (DHAP) from isomerization with intramolecular transfer of hydrogen, d-DHAP from isomerization with incorporation of deuterium from D2O into C-1 of DHAP, and d-GAP from incorporation of deuterium from D2O into C-2 of GAP.	Hydrogen	151-159	triosephosphate isomerase	Oryctolagus cuniculus	61-64
21634014-13	2011	The most important criteria to obtain high CLA productivity and isomer selectivity are (1) absence of a hydrogen donor, (2) absence of catalyst acidity, (3) high metal dispersion, and (4) highly accessible pore architecture.	Hydrogen	104-112	selectin P ligand	Homo sapiens	43-46
21702310-4	2011	RESULTS: H2-rich saline significantly decreased the incidence of DCS from 67.57 to 35.14% and partially counteracted the increases in the total concentration of protein in the bronchoalveolar lavage from 0.33 +/- 0.05 to 0.14 +/- 0.01 mg x ml(-1) (mean +/- SD; P &lt; 0.05), myeloperoxidase activity from 0.86 +/- 0.16 to 0.44 +/- 0.13 U/g, levels of malondialdehyde (MDA) from 0.80 +/- 0.10 to 0.48 +/- 0.05 nmol x mg(-1), 8-hydroxydeoxyguanosine from 253.7 +/- 9.3 to 191.2 +/- 4.8 pg x mg(-1) in the lungs, and MDA level from 1.77 +/- 0.20 to 0.87 +/- 0.23 nmol x mg(-1) in the spinal cord in rat DCS models.	Hydrogen	9-11	myeloperoxidase	Rattus norvegicus	275-290
10441116-5	1999	Second, one of the hydroxyl groups of GSBpd forms a direct hydrogen bond with R13 in hGSTP1-1[V104].GSBpd; in contrast, this hydrogen bond is not observed in the I104 complex.	Hydrogen	59-67	glutathione S-transferase pi 1	Homo sapiens	85-91
10428473-5	1999	1H and 15N chemical shift perturbations induced by complex formation of H-NS(60-137) with an oligonucleotide duplex 14-mer demonstrated that two loop regions, i.e. residues A80-K96 and T110-A117, play an essential role in DNA binding.	Hydrogen	0-2	H-NS	Escherichia coli	72-76
10336569-4	1999	The reduction of the affinity observed with the analogs involving reduction or translocation of the hydroxyls at C-6 and C-11 is indicative of the contribution of these residues to the binding to sodium channels as hydrogen bond donors.	Hydrogen	215-223	complement C6	Rattus norvegicus	113-116
29473308-5	2018	For the hydrogen and oxygen evolution reactions with the Fe-CoP HTPAs in alkaline medium, the low overpotentials of 98 and 230 mV are observed, respectively, and the required cell voltage toward overall water splitting is only as low as 1.59 V for the driving current density of 10 mA cm-2 .	Hydrogen	8-16	caspase recruitment domain family member 16	Homo sapiens	60-63
21454678-0	2011	Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9.	Hydrogen	63-71	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	110-116
29454915-7	2018	All these compounds form hydrophobic interaction, aromatic pi-pi stacking and hydrogen bond efficiently with the Eg5.	Hydrogen	78-86	kinesin family member 11	Homo sapiens	113-116
21678582-0	2011	Preparation and enhanced visible-light photocatalytic H2-production activity of CdS-sensitized Pt/TiO2 nanosheets with exposed (001) facets.	Hydrogen	54-56	CDP-diacylglycerol synthase 1	Homo sapiens	80-83
21678582-4	2011	Deposition of CdS NPs on Pt/TiO(2) NSs caused significant enhancement of the UV and visible-light photocatalytic H(2)-production rates.	Hydrogen	113-117	CDP-diacylglycerol synthase 1	Homo sapiens	14-17
10215897-3	1999	Considerable changes were observed at both 20 : 1 and 10 : 1 ratios (AGA*IM : antithrombin) in 1H as well as 13C chemical shifts.	Hydrogen	95-97	serpin family C member 1	Homo sapiens	78-90
30250892-2	2018	We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6).	Hydrogen	213-221	solute carrier family 9 member A6	Homo sapiens	235-239
10196231-2	1999	Two noncrystallographic methods (a new molecular docking program and 1H NMR spectroscopy) have been used to study the electron transfer complex formed between the cytochrome c peroxidase (CCP) of Paracoccus denitrificans and cytochromes c. For the natural redox partner, cytochrome c550, the results are consistent with a complex in which the heme of a single cytochrome lies above the exposed electron-transferring heme of the peroxidase.	Hydrogen	69-71	cytochrome c, somatic	Equus caballus	163-175
21678582-7	2011	After many replication experiments of the photocatalytic hydrogen production in the presence of lactic acid, the CdS-sensitized Pt/TiO(2) NSs did not show great loss in the photocatalytic activity, confirming that the CdS/Pt/TiO(2) NSs system is stable and not photocorroded.	Hydrogen	57-65	CDP-diacylglycerol synthase 1	Homo sapiens	113-116
21420470-7	2011	However, such epigenetic modification is associated to increased BDNF protein expression only 1h after an environmental challenge and not at baseline or 3h after the challenge, suggesting that the epigenetic modifications do not affect expression under steady-state conditions but allow a fast increase in BDNF levels following stimulation.	Hydrogen	94-96	brain derived neurotrophic factor	Mus musculus	65-69
10333174-9	1999	The putative bioactive conformation is characterized by two structural motifs: i) a C14 pseudo-ring stabilized by a hydrogen bond between the amino group of Cys1 and the carboxylate group of Met4 and a C11 pseudo-ring involving the residues Cys1 and Tic3.	Hydrogen	116-124	cystin 1	Homo sapiens	157-161
29341380-2	2018	A Mott-Schottky catalyst composed of Ni nanoparticles and tailorable nitrogen-doped carbon-foam (Ni/NCF) and thus tunable adsorption energy is presented for highly efficient and selective dehydrogenation of gas-phase methanol to hydrogen and CO even under relatively high weight hourly space velocities (WHSV).	Hydrogen	190-198	neutrophil cytosolic factor 4	Homo sapiens	100-103
10368294-9	1999	In addition, sequence changes in v-cyclin eliminate hydrogen-bonding partners for atoms of the p27(Kip1) inhibitor.	Hydrogen	52-60	proliferating cell nuclear antigen	Homo sapiens	35-41
10368294-9	1999	In addition, sequence changes in v-cyclin eliminate hydrogen-bonding partners for atoms of the p27(Kip1) inhibitor.	Hydrogen	52-60	cyclin dependent kinase inhibitor 1B	Homo sapiens	99-103
21510671-4	2011	In squid rhodopsin, an extended hydrogen bond network that spans ~13 A to Tyr315 on the cytoplasmic site is present regardless of the protonation state of Asp80.	Hydrogen	32-40	rhodopsin	Bos taurus	9-18
21510671-5	2011	In contrast, the extended hydrogen bond network is interrupted at Tyr306 in bovine rhodopsin.	Hydrogen	26-34	rhodopsin	Bos taurus	83-92
29153716-0	2018	Facet and morphology dependent photocatalytic hydrogen evolution with CdS nanoflowers using a novel mixed solvothermal strategy.	Hydrogen	46-54	CDP-diacylglycerol synthase 1	Homo sapiens	70-73
21510671-8	2011	Together with the interhelical hydrogen bonds, the salt bridges between TM6 and H9 stabilize the protein conformation of squid rhodopsin and may hinder the occurrence of large conformational changes that are observed upon activation of bovine rhodopsin.	Hydrogen	31-39	rhodopsin	Bos taurus	127-136
21515056-4	2011	X-ray crystallography has shown this series binding in the CT-domain of ACC2 and revealed two key hydrogen bonding interactions.	Hydrogen	98-106	acetyl-CoA carboxylase beta	Rattus norvegicus	72-76
11674213-2	1999	Tethered Biginelli condensation of enantioenriched hexahydropyrrolopyrimidines 8 with beta-ketoesters provides efficient asymmetric access to tricyclic guanidines 9 having a syn relationship of the angular C2a and C8a hydrogens.	Hydrogen	218-227	complement C8 alpha chain	Homo sapiens	214-217
9988688-0	1999	Functional interaction of mammalian valyl-tRNA synthetase with elongation factor EF-1alpha in the complex with EF-1H.	Hydrogen	114-116	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	81-90
9988688-4	1999	We show here that the addition of EF-1alpha and GTP in excess in the aminoacylation mixture is accompanied by a 2-fold stimulation of valyl-tRNAVal synthesis catalyzed by the valyl-tRNA synthetase component of the ValRS.EF-1H complex.	Hydrogen	223-225	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	34-43
29153716-1	2018	As the highest energy facet of wurtzite CdS, (0 0 2) facet is well worth investigating toward the contribution in photocatalytic hydrogen (H2) evolution.	Hydrogen	129-137	CDP-diacylglycerol synthase 1	Homo sapiens	40-43
29153716-1	2018	As the highest energy facet of wurtzite CdS, (0 0 2) facet is well worth investigating toward the contribution in photocatalytic hydrogen (H2) evolution.	Hydrogen	139-141	CDP-diacylglycerol synthase 1	Homo sapiens	40-43
10195326-1	1999	The proximal histidyl NdeltaH signal of myoglobin is detectable in 1H NMR spectra of myocardial and skeletal muscle, and its intensity reflects the intracellular oxygenation.	Hydrogen	67-69	myoglobin	Homo sapiens	40-49
29153716-6	2018	As expected, the flower-like CdS exhibited the highest photocatalytic activity on H2 evolution under visible light without any co-catalyst.	Hydrogen	82-84	CDP-diacylglycerol synthase 1	Homo sapiens	29-32
21530274-0	2011	New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the gamma-aminobutyric acid type A (GABAA) receptor.	Hydrogen	118-126	defensin beta 103B	Homo sapiens	106-111
29153716-7	2018	Meanwhile, the photocatalytic H2 production increased with the increasement of exposed (0 0 2) facet, which suggested that (0 0 2) facet of CdS played a critical role in improving the photocatalytic activity.	Hydrogen	30-32	CDP-diacylglycerol synthase 1	Homo sapiens	140-143
21530274-4	2011	In the orientations proposed by ADLR, the NH moiety of the pyrrole ring, independently of the position in the pyrazolobenzotriazine core, fits in HBp-3 area and points out the acceptor feature of this hydrogen bond area, already known as donor area.	Hydrogen	201-209	defensin beta 103B	Homo sapiens	146-151
29326159-4	2018	We used hydrogen/deuterium exchange MS to study interactions of SK1 with membrane vesicles.	Hydrogen	8-16	sphingosine kinase 1	Homo sapiens	64-67
20884221-9	2011	The level of CrCl was higher 1h in the on-pump without CA group (+23%, 95% CI +1% to +50%, p=0.04), but not thereafter.	Hydrogen	29-31	CRCL	Homo sapiens	13-17
9885237-8	1999	Thus, targeted radiation delivered via 131I-anti-CD45 antibody can enable engraftment of congenic marrow and can partially replace TBI when transplanting T-cell-depleted H2-mismatched marrow.	Hydrogen	170-172	protein tyrosine phosphatase, receptor type, C	Mus musculus	49-53
9886287-5	1999	Unexpectedly, the single amino acid substitution in HAP1-18 nucleates a significantly altered hydrogen bond interface between the protein and DNA resulting in DNA conformational changes and an ordering of one N-terminal arm of the protein dimer along the DNA minor groove.	Hydrogen	94-102	Hap1p	Saccharomyces cerevisiae S288C	52-56
29414037-6	2018	The more stability of [Fe-P1]2+ was attributed to an intramolecular hydrogen bond formation between the hydrogen atom of NH group and the oxygen atom of CH2OH chain.	Hydrogen	68-76	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	26-28
9819221-9	1998	We propose that the absence of hydrogen-bond formation between a distal residue and exogenous ligands is physiologically relevant in lowering the oxygen affinity of heterodimeric sGC and, therefore, stabilizing the ferrous, active form of the enzyme under aerobic conditions.	Hydrogen	31-39	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	179-182
21462982-5	2011	For GB3 and ubiquitin, good coordinate accuracy was obtained using only backbone hydrogen-bond restraints supplemented by (15)N R(2)/R(1) relaxation restraints.	Hydrogen	81-89	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	4-7
29414037-6	2018	The more stability of [Fe-P1]2+ was attributed to an intramolecular hydrogen bond formation between the hydrogen atom of NH group and the oxygen atom of CH2OH chain.	Hydrogen	104-112	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	26-28
21390401-4	2011	Ga(3+) cations in Ga-MOR dissociatively adsorb molecular hydrogen at elevated temperatures, resulting in the formation of gallium hydride species and acidic hydroxyl groups.	Hydrogen	57-65	opioid receptor mu 1	Homo sapiens	21-24
29313666-4	2018	Previous studies suggest that carbon-1 galactose derivatives show diminished binding since the hydroxyl group in the carbon-1 position of the sugar is a hydrogen bond acceptor in the galectin-1 sugar binding site.	Hydrogen	153-161	galectin 1	Homo sapiens	183-193
21200321-8	2011	Hydrogen-rich saline treatment significantly reduced the level of degraded myelin basic protein, decreased the expression of ionized calcium-binding adapter molecule 1, Iba1, a microglial marker, reduced DNA oxidation, and suppressed proinflammatory cytokine interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in the cortex and hippocampal tissues when compared with those in normal saline-treated rats.	Hydrogen	0-8	allograft inflammatory factor 1	Rattus norvegicus	125-167
21200321-8	2011	Hydrogen-rich saline treatment significantly reduced the level of degraded myelin basic protein, decreased the expression of ionized calcium-binding adapter molecule 1, Iba1, a microglial marker, reduced DNA oxidation, and suppressed proinflammatory cytokine interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in the cortex and hippocampal tissues when compared with those in normal saline-treated rats.	Hydrogen	0-8	allograft inflammatory factor 1	Rattus norvegicus	169-173
9845967-9	1998	Examination of compounds overlayed in the model indicated a possible hydrogen bond acceptor in the DBH active site.	Hydrogen	69-77	dopamine beta-hydroxylase	Homo sapiens	99-102
29328535-2	2018	Based on X-ray analysis and DFT and MP2 calculations, the hydrogen-hydrogen non-bonded contact distance is estimated to be 1.50-1.53 A.	Hydrogen	58-66	tryptase pseudogene 1	Homo sapiens	36-39
9769345-3	1998	This article summarizes in vitro investigations that have been performed to evaluate 1H MR spectroscopy of SCC of the upper aerodigestive tract.	Hydrogen	85-87	serpin family B member 3	Homo sapiens	107-110
15825359-1	1998	A novel compound of Ru2H4 (CO) (PPh3)4 (A) is synthesized under hydrogen atmosphere.	Hydrogen	64-72	protein phosphatase 4 catalytic subunit	Homo sapiens	32-36
21384812-6	2011	The packing structures of these cation-anion compounds are arranged to layered sandwiched structures assembled by an oxo-anion layer and two TTF layers through hydrogen bonding.	Hydrogen	160-168	ras homolog family member H	Homo sapiens	141-144
15825359-3	1998	The structural conversion of RuH4 (PPh3)3 between dihydrogen and dihydride is observed firstly at room temperature.	Hydrogen	50-60	protein phosphatase 4 catalytic subunit	Homo sapiens	35-39
29328535-2	2018	Based on X-ray analysis and DFT and MP2 calculations, the hydrogen-hydrogen non-bonded contact distance is estimated to be 1.50-1.53 A.	Hydrogen	67-75	tryptase pseudogene 1	Homo sapiens	36-39
9731751-0	1998	Activation of the sodium/hydrogen exchanger via the fibronectin-integrin pathway results in hematopoietic stimulation.	Hydrogen	25-33	fibronectin 1	Mus musculus	52-63
29449884-0	2018	Improved photobio-H2 production regulated by artificial miRNA targeting psbA in green microalga Chlamydomonas reinhardtii.	Hydrogen	18-20	photosystem II protein D1	Chlamydomonas reinhardtii	72-76
9737884-9	1998	The salt dependence of binding, together with a recent X-ray structure of the antithrombin-pentasaccharide complex, suggested that the majority of the enhanced affinity of the latter pentasaccharide was due to direct electrostatic and hydrogen-bonding interactions of the H residue 3-O-sulfate with antithrombin.	Hydrogen	235-243	serpin family C member 1	Homo sapiens	78-90
21456637-0	2011	Communication: Single crystal x-ray diffraction observation of hydrogen bonding between 1-propanol and water in a structure II clathrate hydrate.	Hydrogen	63-71	transcription elongation factor A1	Homo sapiens	114-126
21456637-1	2011	Single crystal x-ray crystallography is used to detect guest-host hydrogen bonding in structure II (sII) binary clathrate hydrate of 1-propanol and methane.	Hydrogen	66-74	transcription elongation factor A1	Homo sapiens	86-98
21456637-1	2011	Single crystal x-ray crystallography is used to detect guest-host hydrogen bonding in structure II (sII) binary clathrate hydrate of 1-propanol and methane.	Hydrogen	66-74	transcription elongation factor A1	Homo sapiens	100-103
21456637-8	2011	The individual cage distortions resulting from guest-host hydrogen bonding from the simulations are rather large, but due to the random nature of the hydrogen bonding of the guest with the 24 water molecules making up the hexagonal faces of the large sII cages, these distortions are not observed in the x-ray structure.	Hydrogen	58-66	transcription elongation factor A1	Homo sapiens	251-254
21456637-8	2011	The individual cage distortions resulting from guest-host hydrogen bonding from the simulations are rather large, but due to the random nature of the hydrogen bonding of the guest with the 24 water molecules making up the hexagonal faces of the large sII cages, these distortions are not observed in the x-ray structure.	Hydrogen	150-158	transcription elongation factor A1	Homo sapiens	251-254
21238541-0	2011	Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappaB activation in a rat model of amyloid-beta-induced Alzheimer"s disease.	Hydrogen	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	77-80
9755491-3	1998	Under physiological conditions RAP slowly looses the two coordinated chlorine atoms to produce a number of ruthenium (III) reactive species; a description of the distribution of these species on the dependence of pH has been obtained through 1H NMR studies of the hyperfine shifted signals.	Hydrogen	242-244	LDL receptor related protein associated protein 1	Homo sapiens	31-34
29280205-1	2018	Photocatalytic hydrogen evolution from pure water is successfully realized by using interstitial P-doped CdS with rich S vacancies (CdS-P) as the photocatalyst in the absence of any electron sacrificial agents.	Hydrogen	15-23	CDP-diacylglycerol synthase 1	Homo sapiens	105-108
9714183-1	1998	Thioredoxin (TRX) is an intracellular enzyme that has a variety of activities as a hydrogen donor for various intracellular molecules.	Hydrogen	83-91	thioredoxin	Homo sapiens	0-11
9714183-1	1998	Thioredoxin (TRX) is an intracellular enzyme that has a variety of activities as a hydrogen donor for various intracellular molecules.	Hydrogen	83-91	thioredoxin	Homo sapiens	13-16
9649409-5	1998	Protection factors for slowly exchanging hydrogens in myoglobin are decreased by halothane, suggesting destabilization through binding to an intermediate or completely unfolded conformer.	Hydrogen	41-50	myoglobin	Homo sapiens	54-63
9572847-1	1998	Analysis of the dihydrofolate reductase (DHFR) complex with folate by two-dimensional heteronuclear (1H-15N) nuclear magnetic relaxation revealed that isolated residues exhibit diverse backbone fluctuations on the nanosecond to picosecond time scale [Epstein, D. M., Benkovic, S. J., and Wright, P. E. (1995) Biochemistry 34, 11037-11048].	Hydrogen	101-103	Dihydrofolate reductase	Escherichia coli	16-39
9572847-1	1998	Analysis of the dihydrofolate reductase (DHFR) complex with folate by two-dimensional heteronuclear (1H-15N) nuclear magnetic relaxation revealed that isolated residues exhibit diverse backbone fluctuations on the nanosecond to picosecond time scale [Epstein, D. M., Benkovic, S. J., and Wright, P. E. (1995) Biochemistry 34, 11037-11048].	Hydrogen	101-103	Dihydrofolate reductase	Escherichia coli	41-45
9572848-0	1998	Strength of an interloop hydrogen bond determines the kinetic pathway in catalysis by Escherichia coli dihydrofolate reductase.	Hydrogen	25-33	Dihydrofolate reductase	Escherichia coli	103-126
9702342-1	1998	The model of muscle contraction suggested in [1] is based on the hypothesis that the first step of the conversion of chemical energy delta E (which is stored in adenosine-5"-triphosphate) is the excitation of the hydrogen bond in the actin-myosin system with a simultaneous hydrolysis of the adenosine-5"-triphosphate molecule.	Hydrogen	213-221	myosin heavy chain 14	Homo sapiens	240-246
9554882-2	1998	1H NMR chemical shift assignments for the mammalian NK1 receptor-selective agonists alpha-neurokinin (NKA) and beta-neurokinin (NKB) as well as the mammalian NK1 receptor-selective antagonists [d-Pro2,d-Phe7,d-Trp9]SP and [d-Arg1, d-Pro2,d-Phe7,d-His9]SP have been determined at 600 MHz in sodium dodecyl sulfate (SDS) micelles.	Hydrogen	0-2	tachykinin precursor 3	Homo sapiens	128-131
9554882-2	1998	1H NMR chemical shift assignments for the mammalian NK1 receptor-selective agonists alpha-neurokinin (NKA) and beta-neurokinin (NKB) as well as the mammalian NK1 receptor-selective antagonists [d-Pro2,d-Phe7,d-Trp9]SP and [d-Arg1, d-Pro2,d-Phe7,d-His9]SP have been determined at 600 MHz in sodium dodecyl sulfate (SDS) micelles.	Hydrogen	0-2	tachykinin receptor 1	Homo sapiens	52-64
9548812-9	1998	These inhibitors (1h,i) showed strong activity against DeltaMT1 over MMP-1, but no selectivity between DeltaMT1 and MMP-9.	Hydrogen	18-20	matrix metallopeptidase 1	Homo sapiens	69-74
9576546-12	1998	Nevertheless, the homogeneous metabolic pattern that characterises PML suggests the usefulness of 1H-MRS as an adjunct to MRI in differentiating CNS white matter lesions, such as HIV encephalopathies, from PML.	Hydrogen	98-100	PML nuclear body scaffold	Homo sapiens	67-70
9488681-6	1998	Substitutions at the C-2 position demonstrate that this region of the molecule plays a secondary but significant role in stabilizing cGMP binding to PDE through hydrogen bond interactions.	Hydrogen	161-169	complement C2	Homo sapiens	21-24
21238541-1	2011	This study is to examine if hydrogen-rich saline reduced amyloid-beta (Abeta) induced neural inflammation and oxidative stress in a rat model by attenuation of activation of JNK and NF-kappaB.	Hydrogen	28-36	mitogen-activated protein kinase 8	Rattus norvegicus	174-177
21177415-3	2011	MRT-83 fits to a proposed pharmacophoric model for Smo antagonists with three hydrogen bond acceptor groups and three hydrophobic regions.	Hydrogen	78-86	smoothened, frizzled class receptor	Homo sapiens	51-54
21359214-0	2011	Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase.	Hydrogen	10-18	Dihydrofolate reductase	Escherichia coli	114-137
21162566-8	2011	Differences in the quenching rate constants of the triplet by water and phenols suggest a strong hydrogen-bond interaction with the nitro group in the C-2 position, which provides for radiationless deactivation routes.	Hydrogen	97-105	complement C2	Homo sapiens	151-154
21085725-2	2011	The reaction produces C(2)+ hydrocarbons and hydrogen in a single step at 1 atm in a continuous flow reactor at a nominal residence time of 60 s. The essentially complete conversion of methane appears to be due to protolytic activation of methane in the presence of H(+)AlBr(4)(-).	Hydrogen	45-53	ATM serine/threonine kinase	Homo sapiens	76-79
20554051-9	2011	The role of dynamics in substrate selection was also examined by probing the amide proton exchange rates of EcMTAN and AtMTAN1 via deuterium-hydrogen exchange coupled mass spectrometry.	Hydrogen	141-149	methylthioadenosine nucleosidase 1	Arabidopsis thaliana	119-126
22053188-8	2011	We developed a new automated algorithm that determines additional restraints to iteratively converge towards TCR conformations making frequent hydrogen bonds with the pMHC.	Hydrogen	143-151	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	109-112
21149675-3	2010	DNA strand scission is initiated through the abstraction of the C-4" hydrogen atom of the deoxyribose sugar unit.	Hydrogen	69-77	complement C4A (Rodgers blood group)	Homo sapiens	64-67
21156831-4	2010	NMR and hydrogen-deuterium exchange of this complex in micelles showed that the alphaIIb cytoplasmic domain is largely disordered, but it interacts with and influences the conformation of the beta3 cytoplasmic domain.	Hydrogen	8-16	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	192-197
21156831-7	2010	Hydrogen-deuterium exchange mass spectrometry, as well as circular dichroism spectroscopy, demonstrated that the beta3 cytoplasmic domain becomes more ordered and helical under these conditions, consistent with our NMR results.	Hydrogen	0-8	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	113-118
21522521-3	2010	In the crystal, O-H S, O-H O and C-H S hydrogen bonds link adjacent mol-ecules into layers parallel to the ac plane.	Hydrogen	39-47	Rh associated glycoprotein	Homo sapiens	16-36
20976343-0	2010	Photochemical and thermal hydrogen production from water catalyzed by carboxylate-bridged dirhodium(II) complexes.	Hydrogen	26-34	Rh blood group D antigen	Homo sapiens	100-102
21090588-4	2010	The effect of efavirenz on the solution conformations of p66 and p51 monomers was studied by hydrogen-deuterium exchange mass spectrometry (HXMS) and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).	Hydrogen	93-101	DNA polymerase delta 3, accessory subunit	Homo sapiens	57-60
20664000-3	2010	Here, on the basis of experimental data, we generated and validated a pharmacophoric model for Smo inhibitors constituted by three hydrogen bond acceptor groups and three hydrophobic regions.	Hydrogen	131-139	smoothened, frizzled class receptor	Homo sapiens	95-98
20592030-2	2010	Hydrogen/deuterium exchange coupled to mass spectrometry was used to obtain structural information on the conformational mechanism that underlies p47(phox) activation.	Hydrogen	0-8	pleckstrin	Homo sapiens	146-149
20679715-0	2010	Forced twin-chair conformation in 7-benzoyl- and 7-phenylacetyl-r-2,c-4,t-6,t-8-tetraphenyl-3-thia-7-azabicyclo[3.3.1]nonanes with 1,3-diaxial phenyl groups in the piperidine ring: single- and double-layered supramolecular sheets built from C-H...O and C-H...pi(arene) hydrogen bonds.	Hydrogen	269-277	complement C4A (Rodgers blood group)	Homo sapiens	68-71
20441802-9	2010	Taken together, we show that NHA2 is a RANKL-induced plasmalemmal sodium/hydrogen exchanger in osteoclasts.	Hydrogen	73-81	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	39-44
20119640-6	2010	A mean number of about 14 hydrogen bonds was observed between the active receptor and Galpha(s) for both conformations.	Hydrogen	26-34	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	86-92
20494601-9	2010	A 3-D model of CYP11B2 p.S315R and p.R374W indicated a change of the hydrogen bond network which might explain the cause of the dysfunction.	Hydrogen	69-77	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	15-22
20575550-5	2010	Our data showed that the minimal elements crucial for high-affinity binding of MLL1 to WDR5 are -CO-ARA-NH- motif and two intramolecular hydrogen bonds that stabilize the conformation of this motif.	Hydrogen	137-145	lysine methyltransferase 2A	Homo sapiens	79-83
21587943-1	2010	In the structure of the title compound, C(7)H(10)NO(+) PF(6) (-) H(2)O, the protonated 4-meth-oxy-anilinium cations and hexa-fluoro-phosphate anions are bridged by the water mol-ecule via N-H O and O-H F hydrogen bonds.	Hydrogen	204-212	hexosaminidase subunit alpha	Homo sapiens	120-124
20499940-2	2010	The problems associated with deprotonation of the C-2 hydrogen of [bmim][PF(6)] could be suppressed in the reaction of [bmTr][PF(6)] or [bmTr][NTf(2)].	Hydrogen	54-62	complement C2	Homo sapiens	50-53
20465300-5	2010	Molecular dynamics simulations combined to quantum chemical methods (HF, B3LYP, B3LYP-D, M06-2X, and MP2) showed that hydrogen bonding affects the rotational barriers of TMU and TMT in markedly different ways.	Hydrogen	118-126	tryptase pseudogene 1	Homo sapiens	101-104
20394753-1	2010	We present the crystal structure of an immunoglobulin light-chain-like domain, CTLA-4, as a strand-swapped dimer displaying cis-trans proline isomerisation and native-like hydrogen bonding.	Hydrogen	172-180	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	79-85
20147652-4	2010	Coexpression of KLHL1 with Ca(V)3.1 or Ca(V)3.2 (alpha(1G) or alpha(1H) subunits) caused increases in T-type current density (35%) and calcium influx (75-83%) when carried out by alpha(1H) but not by alpha(1G).	Hydrogen	68-70	immunoglobulin lambda variable 7-43	Homo sapiens	39-47
20147652-4	2010	Coexpression of KLHL1 with Ca(V)3.1 or Ca(V)3.2 (alpha(1G) or alpha(1H) subunits) caused increases in T-type current density (35%) and calcium influx (75-83%) when carried out by alpha(1H) but not by alpha(1G).	Hydrogen	185-187	immunoglobulin lambda variable 7-43	Homo sapiens	39-47
29280205-1	2018	Photocatalytic hydrogen evolution from pure water is successfully realized by using interstitial P-doped CdS with rich S vacancies (CdS-P) as the photocatalyst in the absence of any electron sacrificial agents.	Hydrogen	15-23	CDP-diacylglycerol synthase 1	Homo sapiens	132-135
28884942-8	2018	Molecular docking of SQSPA, STYV, and STY (digestion fragment of STYV) with alpha-glucosidase suggested that their hydrogen bonding interactions and binding energies were comparable with acarbose.	Hydrogen	115-123	sucrase-isomaltase	Homo sapiens	76-93
19899158-7	2010	Based on molecular docking results, dynamic simulation shows that strong hydrophobic interactions and a key hydrogen bond can only exist between R-(+)-FAP and AChE, which helps explain the preference of R-(+) binding to AChE over that of the S-(-)-enantiomer, and supports our biological results.	Hydrogen	108-116	acetylcholinesterase	Rattus norvegicus	159-163
19899158-7	2010	Based on molecular docking results, dynamic simulation shows that strong hydrophobic interactions and a key hydrogen bond can only exist between R-(+)-FAP and AChE, which helps explain the preference of R-(+) binding to AChE over that of the S-(-)-enantiomer, and supports our biological results.	Hydrogen	108-116	acetylcholinesterase	Rattus norvegicus	220-224
29241096-4	2018	Finally, in the particular case of first generation dendrimer [G1O3(NMe2(CH2)2OH))6]6+; the presence of hydroxyl groups reinforces dendriplex stability by hydrogen bonds formation.	Hydrogen	155-163	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	68-72
19887450-6	2010	The overtly electrostatic character of HA binding in Lyve-1 and its sensitivity to ionic strength (IC(50) of 150 mm NaCl) contrast markedly with CD44 (IC(50) &gt; 2 m NaCl) in which HA binding is mediated by hydrogen bonding and hydrophobic interactions.	Hydrogen	208-216	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	53-59
20188552-4	2010	An X-ray co-crystal structure of one inhibitor with the mTOR-related PI3Kgamma revealed the key hydrogen bonding interactions.	Hydrogen	96-104	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	69-78
10526969-6	1998	We could demonstrate a reaction (pH = 7.5, 37 degrees C, 1h) between HMA and tetrahydrofolate (THF) producing N5,N10-methylene-tetrahydrofolate (CH2-THF), the coenzyme of thymidylate synthase (TS).	Hydrogen	57-59	thymidylate synthetase	Homo sapiens	171-191
29194945-4	2018	The resulting homologous Co3 O4 and CoP NSs display outstanding catalytic activity in alkaline media toward the oxygen evolution reaction and the hydrogen evolution reaction, respectively, ascribed to the richly exposed active sites, and the expedited electrolyte/ion transmission path.	Hydrogen	146-154	caspase recruitment domain family member 16	Homo sapiens	36-39
11671972-3	1997	The inversion barriers of 4a and 4b (10.3 and 10.8 kcal mol(-1)) are similar to that determined for the endo-dihydroxycalixarene 12, indicating that the additional intramolecular hydrogen bond between the exo OH groups does not decrease the flexibility of the molecule.	Hydrogen	179-187	mannosidase endo-alpha	Homo sapiens	104-108
20164409-4	2010	Measurements on three beta-PGM-MgF-3 -sugar phosphate complexes show a remarkable relationship between NMR chemical shifts, primary isotope shifts, NOEs, cross hydrogen bond F...H-N scalar couplings, and the atomic positions determined from the high-resolution crystal structure of the beta-PGM-MgF--3 -G6P complex.	Hydrogen	160-168	signal transducer and activator of transcription 5A	Homo sapiens	31-34
29371621-6	2018	Most importantly, based on the simulation observation that resveratrol has a high probability of forming hydrogen bonds with sn-1 and sn-2 ester groups, we discovered a new mechanism using experimental approach, in which resveratrol protects both sn-1 and sn-2 ester bonds of DPPC and distearoyl phosphatidylcholine (DSPC) from phospholipase A1 (PLA1) and phospholipase A2 (PLA2) cleavage.	Hydrogen	105-113	POU class 2 homeobox 3	Homo sapiens	346-350
29260180-8	2018	The 1H resonances of [Fe(2MPC)]2+ appear at 105 ppm and -46 ppm with corresponding temperature coefficients (CT) of -0.29 ppm  C-1 and 0.22 ppm  C-1, respectively.	Hydrogen	4-6	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	127-130
20079802-2	2010	CD-1 male mice inhaled a mixture of 0.04 M manganese chloride (MnCl(2)) and manganese acetate (Mn(OAc)(3)), 1h twice a week for 5 months.	Hydrogen	108-110	CD1 antigen complex	Mus musculus	0-4
19669810-9	2010	Furthermore, two hydrogen bonds were predicted in both complexes PB1-F2/VDAC1 and PB1-F2/ANT3.	Hydrogen	17-25	solute carrier family 25 member 6	Homo sapiens	89-93
9431028-2	1997	Z-1 and E-1 were separated by column chromatography and identified by 1H NMR.	Hydrogen	70-72	small nucleolar RNA, H/ACA box 73A	Homo sapiens	0-11
29260180-8	2018	The 1H resonances of [Fe(2MPC)]2+ appear at 105 ppm and -46 ppm with corresponding temperature coefficients (CT) of -0.29 ppm  C-1 and 0.22 ppm  C-1, respectively.	Hydrogen	4-6	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	145-148
28972688-3	2018	Herein, we report a new, highly active, noble-metal-free, and redox-mediator-free Z-scheme photocatalyst, CdS/Co-C@Co9 S8 , for H2 production through water splitting under solar irradiation.	Hydrogen	128-130	CDP-diacylglycerol synthase 1	Homo sapiens	106-109
9370470-1	1997	The detection of the 1H NMR signal of myoglobin (Mb) in tissue opens an opportunity to examine its cellular diffusion property, which is central to its purported role in facilitating oxygen transport.	Hydrogen	21-23	myoglobin	Homo sapiens	49-51
20032459-9	2010	Unlike Ala substitutions, the Cys-to-Ser mutation in MBD2 preserves the conformation and reduced state of N-ATP7B, suggesting that hydrogen bonds contribute to interdomain communications.	Hydrogen	131-139	methyl-CpG binding domain protein 2	Homo sapiens	53-57
28972688-6	2018	The optimized catalyst shows a H2 evolution rate of 26.69 mmol g-1  h-1 under simulated solar irradiation, which is 46 times higher than that of the as-synthesized CdS mesoporous nanostructures.	Hydrogen	31-33	CDP-diacylglycerol synthase 1	Homo sapiens	164-167
29975948-13	2018	Some of the active ingredients in XH share a common cyclopentane hydrogen skeleton and were predicted to target ERalpha based on the structural similarity.	Hydrogen	65-73	estrogen receptor 1 (alpha)	Mus musculus	112-119
20121089-2	2010	A mechanism that involves abstraction of hydrogen atoms at C-9 and/or C-14 is proposed to account for the formation of all of the oxysterols and the reaction progress profile.	Hydrogen	41-49	complement component 9	Mus musculus	59-62
9566768-7	1997	The binding data strongly suggest that this hydrogen bond connects the estradiol 17-hydroxyl group with the side chain of Gln H35.	Hydrogen	44-52	H3.5 histone	Homo sapiens	126-129
9346914-5	1997	The complex is formed following reduction of alpha-lactalbumin by dithiothreitol in the presence of alpha-crystallin, and this interaction has been monitored in real time by 1H NMR spectroscopy.	Hydrogen	174-176	lactalbumin alpha	Bos taurus	45-62
29207336-6	2018	Docking simulation studies against the two proteins EGFR and DHFR demonstrate that compound 8 showed higher binding affinity toward the two proteins more than compound 5, suggesting that trimethoxy groups may be responsible for this higher activity through the formation of five hydrogen bonding with the active domain (4r3r) and other four interactions with the active domain (1dls).	Hydrogen	279-287	dihydrofolate reductase	Homo sapiens	61-65
9335524-1	1997	Purified recombinant human liver cytochrome P450 2C9 was produced, from expression of the corresponding cDNA in yeast, in quantities large enough for UV-visible and 1H NMR experiments.	Hydrogen	165-167	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	33-52
9335524-5	1997	Interactions of the five substrates with the enzyme were studied by paramagnetic relaxation effects of CYP 2C9-iron(III) on the 1H NMR spectrum of each substrate.	Hydrogen	128-130	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	103-110
20038641-0	2010	Cutting edge: HLA-DM-mediated peptide exchange functions normally on MHC class II-peptide complexes that have been weakened by elimination of a conserved hydrogen bond.	Hydrogen	154-162	major histocompatibility complex, class II, DM alpha	Homo sapiens	14-20
19544076-1	2010	The variation in reaction dynamics of OH hydrogen abstraction from glycine between HF, MP2, CCSD(T), M05-2X, BHandHLYP, and B3LYP levels was demonstrated.	Hydrogen	41-49	tryptase pseudogene 1	Homo sapiens	87-90
9399148-5	1997	F12A and I13A substitutions in the SRY HMG box each permit native folding and thermal stability (as monitored by circular dichroism and 1H-NMR) but eliminate sequence-specific DNA-binding activity (as detected by gel-mobility shift).	Hydrogen	136-138	sex determining region Y	Homo sapiens	35-38
30700993-0	2018	Native State of Complement Protein C3d Analysed via Hydrogen Exchange and Conformational Sampling.	Hydrogen	52-60	endogenous retrovirus group K member 13	Homo sapiens	35-38
9275236-8	1997	We propose that this tertiary structure is maintained as a result of a hydrogen bond between the hydroxyl of Tyr-82 and the carbonyl of Tyr-117, which is located in the long alpha-helix; amino acid components of this helix (Leu-111 to Phe-128) have been implicated in G-actin and F-actin binding.	Hydrogen	71-79	actin-7	Zea mays	270-275
9275236-8	1997	We propose that this tertiary structure is maintained as a result of a hydrogen bond between the hydroxyl of Tyr-82 and the carbonyl of Tyr-117, which is located in the long alpha-helix; amino acid components of this helix (Leu-111 to Phe-128) have been implicated in G-actin and F-actin binding.	Hydrogen	71-79	actin-7	Zea mays	282-287
20122159-11	2010	The ability of T477A to restore RT heterodimer formation and thus intravirion stability of the enzyme may arise from increased conformation flexibility in the RT p51 downward arrowRNH cleavage site region, due to loss of a hydrogen bond associated with the normal threonine residue, thereby enabling proteolytic cleavage near the normal RT p51 downward arrowRNH cleavage site.	Hydrogen	223-231	tumor protein p63	Homo sapiens	162-165
28657666-5	2018	MD simulations reveal a decrease in the average number of hydrogen bonds in the loop regions on D59P mutation that enhances conformational flexibility, which lead to higher aggregation propensity of D59P as compare to wt beta2m.	Hydrogen	58-66	beta-2-microglobulin	Homo sapiens	221-227
19955606-0	2010	The heat annealing effect on the performance of CdS/CdSe-sensitized TiO2 photoelectrodes in photochemical hydrogen generation.	Hydrogen	106-114	CDP-diacylglycerol synthase 1	Homo sapiens	48-51
9315320-1	1997	Thioredoxin (Trx) is a small ubiquitous dithiol protein which together with the FAD-containing enzyme thioredoxin reductase (TR) and NADPH (the Trx system) is a hydrogen donor for ribonucleotide reductase essential for DNA synthesis and a general protein disulfide reductase involved in redox regulation.	Hydrogen	161-169	thioredoxin	Homo sapiens	102-113
9315320-1	1997	Thioredoxin (Trx) is a small ubiquitous dithiol protein which together with the FAD-containing enzyme thioredoxin reductase (TR) and NADPH (the Trx system) is a hydrogen donor for ribonucleotide reductase essential for DNA synthesis and a general protein disulfide reductase involved in redox regulation.	Hydrogen	161-169	thioredoxin	Homo sapiens	144-147
29025655-2	2018	In this work, the hydrogen bond of nucleic acid was introduced into the above-mentioned SHG by syntheses of nucleobase guanine/cytosine (G/C)-terminated PEG (G-PEG-G/C-PEG-C).	Hydrogen	18-26	progestagen associated endometrial protein	Homo sapiens	153-156
9254611-2	1997	Recombinant murine LIF was studied by multidimensional homonuclear and 1H-15N heteronuclear NMR and 95% of backbone amide resonances assigned.	Hydrogen	71-73	leukemia inhibitory factor	Mus musculus	19-22
9254611-7	1997	The dynamics of the polypeptide backbone of LIF were assessed from 15N T1 and T2 relaxation times and 15N-1H heteronuclear NOEs of the amide groups.	Hydrogen	106-108	leukemia inhibitory factor	Mus musculus	44-47
9254617-10	1997	The C=O stretching frequency occurs near 1663 cm-1 in non-hydrogen bonding solvents such as CCl4, near 1650 cm-1 in aqueous solution, and near 1610 cm-1 in the active site of dehalogenase.	Hydrogen	58-66	C-C motif chemokine ligand 4	Homo sapiens	92-96
9254617-18	1997	An FTIR study on the model compound 4-methylbenzoyl S-ethyl thioester, binding to a number of hydrogen bonding donors in CCl4, is described and is used to relate the observed shift of the C=O stretching mode of 4-MeBA-CoA in the active site to the hydrogen bonding strength value.	Hydrogen	94-102	C-C motif chemokine ligand 4	Homo sapiens	121-125
20080730-4	2010	We solve the crystal structure of hPOT1 bound to DNA with a ribouridine in lieu of the critical deoxythymidine and show that this substitution results in burying the 2(")-hydroxyl group in a hydrophobic region (Phe62) of POT1 in addition to eliminating favorable hydrogen-bonding interactions at the POT1-nucleic acid interface.	Hydrogen	263-271	protection of telomeres 1	Homo sapiens	34-39
20080730-4	2010	We solve the crystal structure of hPOT1 bound to DNA with a ribouridine in lieu of the critical deoxythymidine and show that this substitution results in burying the 2(")-hydroxyl group in a hydrophobic region (Phe62) of POT1 in addition to eliminating favorable hydrogen-bonding interactions at the POT1-nucleic acid interface.	Hydrogen	263-271	protection of telomeres 1	Homo sapiens	35-39
19941855-4	2010	Comparison with the inhibitor binding mode of meso-BDH highlights the role of a hydrogen-bond from a conserved Trp residue(192).	Hydrogen	80-88	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	51-54
29025655-2	2018	In this work, the hydrogen bond of nucleic acid was introduced into the above-mentioned SHG by syntheses of nucleobase guanine/cytosine (G/C)-terminated PEG (G-PEG-G/C-PEG-C).	Hydrogen	18-26	progestagen associated endometrial protein	Homo sapiens	158-173
29148740-3	2017	We have used multidimensional nuclear magnetic resonance methods to assign 1H and 15N backbone amide and 13C backbone and side chain chemical shifts in the denatured state of iso-1-cytochrome c carrying the Lys54   His mutation in 3 and 6 M guanidine hydrochloride and at both pH 6.4, where the His54-heme loop is formed, and pH 3.6, where the His54-heme loop is broken.	Hydrogen	75-77	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	175-180
20596243-2	2010	Several cancers including breast, lung, brain, pancreatic, skin, and colorectal cancers show aberrant modulation of several key HS biosynthetic enzymes such as 3-O Sulfotransferase and 6-O Sulfotransferase, and also catabolic enzymes such as HSulf-1, HSulf-2 and heparanase.	Hydrogen	128-130	sulfatase 2	Homo sapiens	251-258
9244397-7	1997	Thus, although the myoglobin-promoted hydroxylation of linoleic acid into 11-hydroxylinoleic acid lacked apparent stereospecificity and produced equal amounts of the R and S enantiomers, the course of the reaction was stereospecific and involved hydrogen abstraction and oxygen insertion occurring with retention of absolute configuration of the carbon atom hydroxylated.	Hydrogen	246-254	myoglobin	Homo sapiens	19-28
9261869-5	1997	The functional implications of Tyr7 in the activation of the glutathione thiol group are discussed in the light of present results, which in agreement with previous studies suggest that Tyr7 in un-ionized form contributes to the catalytic process of glutathione S-transferase, the thiolate anion being stabilized by hydrogen bond with Tyr7 and by interactions with hydrating water molecules.	Hydrogen	316-324	glutathione S-transferase kappa 1	Homo sapiens	250-275
9271248-8	1997	Other reactions must therefore be considered, including hydrogen abstraction from positions allylic to the polyene chain (C-4 of beta,beta-carotene and its derivatives, and of lycopene).	Hydrogen	56-64	complement C4A (Rodgers blood group)	Homo sapiens	122-125
20373211-3	2010	In order to identify essential chemical functional features for Hsp90 inhibition, a pharmacophore model consisting of one hydrogen bond donor, two hydrogen bond acceptor lipid and one hydrophobic feature has been developed using Hypogen (Catalyst 2.0 software) on a total set of 103 inhibitors consisting of 16 and 87 compounds in the training and the test set, respectively.	Hydrogen	122-130	heat shock protein 90 alpha family class A member 1	Homo sapiens	64-69
9219539-1	1997	The three-dimensional structure of neuropeptide tyrosine (NPY) 13-36, a specific Y2 receptor agonist, has been investigated by two-dimensional 1H-NMR spectroscopy in solution.	Hydrogen	143-145	neuropeptide Y	Homo sapiens	58-61
29037842-6	2017	Pre-treatment with puerarin (50-200muM) for 1h significantly attenuated the ox-LDL-induced TF expression, augmented the phosphorylation of Akt, with a resultant increase of the NO production, and inhibited the activation of ERK1/2 and NF-kappaB (P&lt;0.01).	Hydrogen	44-46	coagulation factor III, tissue factor	Homo sapiens	91-93
11671522-3	1997	A highly stereoselective dissociation pathway involving beta-hydrogen elimination and cross-ring cleavages was observed in complexes possessing equatorial C-2 substituents.	Hydrogen	61-69	complement C2	Homo sapiens	155-158
11671522-4	1997	(2)H- and (13)C-labeling experiments indicate that the hydrogen on C-2 and a labile proton are involved in the beta-hydrogen elimination.	Hydrogen	55-63	complement C2	Homo sapiens	67-70
29086476-3	2017	All results are consistent with the initial formation of [(n PDI2 )Co2 (mu-N)(PMe3 )2 ]3+ , followed by 1) PMe3 attack on the nitride, 2) net hydrogen-atom transfer to form N-H bonds, or 3) C-H amination of the alkyl linker of the n PDI2 ligand.	Hydrogen	142-150	complement C2	Homo sapiens	67-70
11671522-4	1997	(2)H- and (13)C-labeling experiments indicate that the hydrogen on C-2 and a labile proton are involved in the beta-hydrogen elimination.	Hydrogen	116-124	complement C2	Homo sapiens	67-70
9113332-4	1997	In addition, an interaction site for the side-chain of Gln-165 in the human NK1 receptor that is probably involved in donating a hydrogen bond to the benzylamino nitrogen or benzylether oxygen of the quinuclidine and piperidine antagonists is explicitly postulated.	Hydrogen	129-137	tachykinin receptor 1	Homo sapiens	76-88
9027305-1	1997	The hydrogen atoms are located in square pyramidal cavities of the Rh13 cluster, in positions almost coplanar with the Rh4 faces on the surface of the cluster.	Hydrogen	4-12	Rh blood group D antigen	Homo sapiens	119-122
9033386-5	1997	Lys211 of the K3 mutant, which corresponds to Lys111 of E-selectin, interacts with each of the three bound ligands: the N zeta atom donates a hydrogen bond to the 4-OH of Gal in 3"-NeuAc-Le(x), forms a water-mediated hydrogen bond with the 4-OH of Gal in 3"-sulfo-Le(x), and forms a salt bridge with the sulfate group of 4"-sulfo-Le(x).	Hydrogen	142-150	selectin E	Homo sapiens	56-66
9033386-5	1997	Lys211 of the K3 mutant, which corresponds to Lys111 of E-selectin, interacts with each of the three bound ligands: the N zeta atom donates a hydrogen bond to the 4-OH of Gal in 3"-NeuAc-Le(x), forms a water-mediated hydrogen bond with the 4-OH of Gal in 3"-sulfo-Le(x), and forms a salt bridge with the sulfate group of 4"-sulfo-Le(x).	Hydrogen	217-225	selectin E	Homo sapiens	56-66
9089810-6	1997	In addition, a hydrogen bond between the hydroxyl group of Tyr36 of NPY and the side chain of Gln219, an interaction that is absent in the model complex between Y1 and the antagonist BIBP3226, is proposed as one of the potential interactions necessary for receptor activation.	Hydrogen	15-23	neuropeptide Y	Homo sapiens	68-71
8995843-1	1996	HCN, a new 3D NMR technique for stepwise coherence transfer from 1H to 13C to 15N and reverse through direct spin couplings 1JCH and 1JCN, is presented as a method for detection and assignment of histidine and tryptophan side-chain 1H, 13C, and 15N resonances in uniformly 13C/15N-labeled proteins.	Hydrogen	232-234	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-3
8994122-2	1996	Proton magnetic spectroscopy (1H-MRS) investigation was performed on CSF samples of patients with neurological inflammatory diseases including 52 cases of multiple sclerosis (MS).	Hydrogen	30-32	colony stimulating factor 2	Homo sapiens	69-72
8994122-13	1996	Formate changes might be related to a disorder of choline-glycine cycle in MS. 1H-MRS in vivo showed significant increase of choline in acute plaques, whereas a decrease of N-acetyl aspartate was found in chronic plaques; these metabolites are undetectable in CSF.	Hydrogen	79-81	colony stimulating factor 2	Homo sapiens	260-263
8994122-15	1996	These observations suggest that 1H-MRS may be able to detect CSF metabolic impairment in neurological inflammatory diseases.	Hydrogen	32-34	colony stimulating factor 2	Homo sapiens	61-64
8880916-4	1996	Analysis of 1H-13C HSQC data acquired for the FKBP-12/ 13C-FK506 and FKBP-12/13C-FK506/CnB/BBD complexes indicates that FKBP-12/FK506 and CnB/BBD are in fast exchange in the quaternary complex.	Hydrogen	12-14	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	46-53
8880916-4	1996	Analysis of 1H-13C HSQC data acquired for the FKBP-12/ 13C-FK506 and FKBP-12/13C-FK506/CnB/BBD complexes indicates that FKBP-12/FK506 and CnB/BBD are in fast exchange in the quaternary complex.	Hydrogen	12-14	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	69-76
8880916-4	1996	Analysis of 1H-13C HSQC data acquired for the FKBP-12/ 13C-FK506 and FKBP-12/13C-FK506/CnB/BBD complexes indicates that FKBP-12/FK506 and CnB/BBD are in fast exchange in the quaternary complex.	Hydrogen	12-14	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	69-76
8691139-7	1996	Molecular modeling indicated that the most obvious consequence of amino acid variation between peptide/H-2K(b) and peptide/H-2K(bm)8 complexes would be a loss of the conserved hydrogen bond network in the B pocket of the latter.	Hydrogen	176-184	histocompatibility 2, K1, K region	Mus musculus	103-109
8683583-0	1996	1H, 15N resonance assignment and three-dimensional structure of CYP1 (HAP1) DNA-binding domain.	Hydrogen	0-2	Hap1p	Saccharomyces cerevisiae S288C	70-74
8639560-9	1996	1H, 13C, and 15N resonances of the SH2 domain of blk kinase were assigned by analysis of multidimensional, double- and triple-resonance NMR experiments.	Hydrogen	0-2	BLK proto-oncogene, Src family tyrosine kinase	Homo sapiens	49-52
8639565-5	1996	The effects of hydrogen ion concentration suggest that the blue and near-UV photopigments are tautomeric forms of RGR, in which an all-trans-retinal Schiff base is protonated or unprotonated, respectively.	Hydrogen	15-23	retinal G protein coupled receptor	Bos taurus	114-117
8887367-10	1996	Lastly, 1H in vitro NMR spectroscopy of the PC3 line performed on perchloric extracts of both supernatants and cells growing in the presence of (1-13C) glucose, allowed simultaneous detection of glucose and lactate as well as estimation of the lactate-specific enrichment.	Hydrogen	8-10	chromobox 8	Homo sapiens	44-47
8605632-5	1996	The carboxylate of Asp 49 forms hydrogen bonds to four conserved, catalytic residues in the beta-lactamase, thereby mimicking the position of the penicillin G carboxylate observed in the acyl-enzyme complex of TEM-1 with substrate.	Hydrogen	32-40	CD248 molecule	Homo sapiens	210-215
8552606-9	1996	Hydrogen bonding is likely to play a significant role in actin-actin and actin-myosin interactions since many of the contacts involve loops.	Hydrogen	0-8	myosin heavy chain 14	Homo sapiens	79-85
8555200-8	1996	The stabilization of the protonated side chain of Asp26 in human thioredoxin is achieved via a hydrogen-bonding network involving the hydroxyl group of the neighboring Ser28 which is then connected to the active site region (comprising Cys32 and Cys35) via bound water molecules.	Hydrogen	95-103	thioredoxin	Homo sapiens	65-76
9188197-2	1996	The organism coupled reductive dehalogenation of tetrachloroethene or trichloroethene to cis-1,2-dichloroethene to growth, using molecular hydrogen as the electron donor.	Hydrogen	139-147	suppressor of cytokine signaling 1	Homo sapiens	89-94
8907170-1	1996	The molecular structure of the active site of horse heart met-cyano cytochrome c, as a function of temperature, has been investigated using 1H-NMR.	Hydrogen	140-142	cytochrome c, somatic	Equus caballus	68-80
8520223-5	1995	The resolution and sensitivity of 2D 15N-1H HSQC spectra of MLC2 were markedly improved by the addition of 25 mM CHAPS, consistent with a reduction in aggregation following addition of the detergent.	Hydrogen	41-43	myosin light chain 2	Homo sapiens	60-64
7545784-7	1995	This site on the self Ag, which encompasses at least three discontinuous segments of the polypeptide chain, is comparable in size to epitopes on other protein Ag that have been mapped by X-ray crystallography and is similar to an epitope in the corresponding region of the foreign Ag, horse cytochrome c, that has been mapped by hydrogen-deuterium exchange.	Hydrogen	329-337	cytochrome c, somatic	Equus caballus	291-303
8948466-7	1995	1H-NMR spectroscopy of 10-HCO-H2folate (in 2H2O; 300 MHz) suggested a pure compound and gave resonances for one formyl group proton, two protons on C-7 and C-9, and no evidence for a C-6 proton, which is consistent with the structure proposed.	Hydrogen	0-2	complement C7	Gallus gallus	148-151
7777501-4	1995	Directional hydrogen-bonding interaction between the tip molecules and the surface molecules could be measured only when opposite base-pair coatings were used.	Hydrogen	12-20	TOR signaling pathway regulator	Homo sapiens	53-56
7779775-2	1995	The N-terminal residues of phospholipase A2 (PLA2) are believed to be involved in the hydrogen-bonding network, the interfacial binding site, or the hydrophobic channel.	Hydrogen	86-94	LOC104974671	Bos taurus	27-43
7779775-2	1995	The N-terminal residues of phospholipase A2 (PLA2) are believed to be involved in the hydrogen-bonding network, the interfacial binding site, or the hydrophobic channel.	Hydrogen	86-94	LOC104974671	Bos taurus	45-49
7727420-0	1995	1H and 15N magnetic resonance assignments, secondary structure, and tertiary fold of Escherichia coli DnaJ(1-78).	Hydrogen	0-2	DnaJ	Escherichia coli	102-106
20418627-4	2010	The experiments of photocatalytic H(2) generation showed that the catalysts (CdS)(x)/(ZnS)(1-x) with x ranging from 0.1 to 1 were able to produce hydrogen from water photolysis under visible light.	Hydrogen	146-154	CDP-diacylglycerol synthase 1	Homo sapiens	77-80
20418627-8	2010	The results demonstrate that the (CdS)/(ZnS) core/shell nano-particles are a novel photo-catalyst for renewable hydrogen generation from water under visible light.	Hydrogen	112-120	CDP-diacylglycerol synthase 1	Homo sapiens	34-37
19720452-7	2009	The different behaviors of individual dyes adsorption on CAS were largely dependent on the number of hydrophilic functional groups, which had strong tendency to form hydrogen bonds with the biosorbent.	Hydrogen	166-174	BCAR1 scaffold protein, Cas family member	Homo sapiens	57-60
19830767-0	2009	Theoretical study of the interplay between lithium bond and hydrogen bond in complexes involved with HLi and HCN.	Hydrogen	60-68	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	109-112
28914497-6	2017	Another important source for hydrogen is hydrogen sulfide, which is abundantly found in Black Sea deep water.	Hydrogen	29-37	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	94-97
19886649-4	2009	In the case of hydrogen abstraction, the resulting carotene radical CAR(-H)(*) has a smaller O(2) affinity than the linoleic acid radical (LA(*)).	Hydrogen	15-23	CXADR pseudogene 1	Homo sapiens	68-71
19886649-7	2009	Both the hydrogen abstraction and addition radicals (CAR(-H)(*) and ROO-CAR(*)) react readily with a second ROO(*) radical via either hydrogen abstraction or addition.	Hydrogen	9-17	CXADR pseudogene 1	Homo sapiens	53-56
19886649-7	2009	Both the hydrogen abstraction and addition radicals (CAR(-H)(*) and ROO-CAR(*)) react readily with a second ROO(*) radical via either hydrogen abstraction or addition.	Hydrogen	9-17	CXADR pseudogene 1	Homo sapiens	72-75
19886649-7	2009	Both the hydrogen abstraction and addition radicals (CAR(-H)(*) and ROO-CAR(*)) react readily with a second ROO(*) radical via either hydrogen abstraction or addition.	Hydrogen	134-142	CXADR pseudogene 1	Homo sapiens	53-56
19886649-7	2009	Both the hydrogen abstraction and addition radicals (CAR(-H)(*) and ROO-CAR(*)) react readily with a second ROO(*) radical via either hydrogen abstraction or addition.	Hydrogen	134-142	CXADR pseudogene 1	Homo sapiens	72-75
7721776-7	1995	Fuc-TIII and Fuc-TV catalyzed fucose transfer exclusively to OH-3 of glucose in lacto-N-neotetraose and lacto-N-tetraose, respectively, as was demonstrated by 1H NMR spectroscopy.	Hydrogen	159-161	fucosyltransferase 3 (Lewis blood group)	Homo sapiens	0-8
7744070-0	1995	1H, 13C, 15N-NMR resonance assignments of oxidized thioredoxin h from the eukaryotic green alga Chlamydomonas reinhardtii using new methods based on two-dimensional triple-resonance NMR spectroscopy and computer-assisted backbone assignment.	Hydrogen	0-2	thioredoxin	Homo sapiens	51-62
28914497-7	2017	Hydrogen produced by electrolysis of Black Sea deep water can also be used in hydrogen fuel cells.	Hydrogen	0-8	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	43-46
7744072-0	1995	Assignment and secondary-structure determination of monomeric bovine seminal ribonuclease employing computer-assisted evaluation of homonuclear three-dimensional 1H-NMR spectra.	Hydrogen	162-164	seminal ribonuclease	Bos taurus	69-89
28914497-7	2017	Hydrogen produced by electrolysis of Black Sea deep water can also be used in hydrogen fuel cells.	Hydrogen	78-86	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	43-46
19780117-3	2009	Hydrogen adsorption measurements at 77 K and 1 atm indicate that the compound exhibits a hydrogen uptake of 0.71 wt %.	Hydrogen	89-97	ATM serine/threonine kinase	Homo sapiens	47-50
28969581-6	2017	RESULTS: Berberine was found to interact with Lys395 of Smo receptor via hydrogen bonding and cation-pi interactions.	Hydrogen	73-81	smoothened, frizzled class receptor	Homo sapiens	56-59
7724588-5	1995	An explanation for the binding of dGMP was provided by x-ray diffraction studies that revealed an extensive stacking interaction between the guanine of dGMP and the benzoquinazoline ring of U89 and hydrogen bonds similar to those involved in dUMP binding.	Hydrogen	198-206	fliF	Drosophila melanogaster	34-38
7724588-5	1995	An explanation for the binding of dGMP was provided by x-ray diffraction studies that revealed an extensive stacking interaction between the guanine of dGMP and the benzoquinazoline ring of U89 and hydrogen bonds similar to those involved in dUMP binding.	Hydrogen	198-206	fliF	Drosophila melanogaster	152-156
7724588-6	1995	In addition, binding energy was provided through a water molecule that formed hydrogen bonds to both N7 of dGMP and the hydroxyl of Tyr-94.	Hydrogen	78-86	fliF	Drosophila melanogaster	107-111
19846764-5	2009	Remodeling the environment of the hydrogen bond donor with a compensatory network of ordered waters, as seen in the Glu(L34) to alanine mutant, leads to an impressive 10(9)-fold rate acceleration over the nonenzymatic reaction with acetate, illustrating the utility of buried water molecules in bifunctional catalysis.	Hydrogen	34-42	ribosomal protein L34	Homo sapiens	116-123
7535385-8	1995	This distance is compatible with hydrogen and metal coordination bonds between P-selectin and PSGL-1.	Hydrogen	33-41	selectin P	Homo sapiens	79-89
29151689-10	2017	While earliest morphological signs of inflammation in liver were visible after 6 h, increased expression of the two acute-phase cytokines IFN-gamma (1h) and IL-1beta (3h) was detectable earlier, with maximum values after 12-24 h. Iron concentrations in liver tissue increased steadily between 1 h and 48 h, and remained high at 96 h. In contrast, spleen iron concentrations remained unchanged until 48 h, and increased mildly thereafter (96 h).	Hydrogen	149-151	interferon gamma	Rattus norvegicus	138-147
7535385-8	1995	This distance is compatible with hydrogen and metal coordination bonds between P-selectin and PSGL-1.	Hydrogen	33-41	selectin P ligand	Homo sapiens	94-100
7733370-0	1995	Critical intracellular O2 in myocardium as determined by 1H nuclear magnetic resonance signal of myoglobin.	Hydrogen	57-59	myoglobin	Homo sapiens	97-106
28890349-7	2017	RT-qPCR showed that H2 up-regulated expression of Kcnc3, a H3K27-regulated gene, in organs such as liver, lung, kidney and brain.	Hydrogen	20-22	potassium voltage-gated channel subfamily C member 3	Rattus norvegicus	50-55
7733370-1	1995	The 1H nuclear magnetic resonance (NMR) signal of tissue myoglobin has provided an opportunity to determine the critical O2 level in saline-perfused myocardium at room temperature.	Hydrogen	4-6	myoglobin	Homo sapiens	57-66
19795866-1	2009	Absolute rate constants were determined for the abstraction of hydrogen atoms from (OC)(3)Fe(mu-SH)(2)Fe(CO)(3) (Fe(2)S(2)H(2)) and (OC)(3)Fe(mu-SCH(3))(mu-SH)Fe(CO)(3) (Fe(2)S(2)MeH) by benzyl radicals in benzene.	Hydrogen	63-71	epoxide hydrolase 1	Homo sapiens	179-182
19678655-1	2009	For the synthesis of endo-configured cyclopropylidenes annelated to benzonorbornadiene, first the exo-bridge hydrogen in benzonorbornadiene was blocked with ethyl, bromine, and methoxy groups.	Hydrogen	109-117	mannosidase endo-alpha	Homo sapiens	21-25
29109444-3	2017	With the participation of CoP particles, there is drastically enhanced  photocatalytic activity of TiO2(B)/anatase, and the H2-production rate can be up to 7400 mumol g-1, which is about 3.2 times higher than TiO2(B)/anatase photocatalyst.	Hydrogen	124-126	caspase recruitment domain family member 16	Homo sapiens	26-29
7707376-4	1995	These water molecules from multiple hydrogen bonds bridging loops and/or secondary structural elements in crystal structures of hDHFR and so stabilize the tertiary fold of the enzyme.	Hydrogen	36-44	dihydrofolate reductase	Homo sapiens	128-133
7707376-6	1995	In crystal structures of hDHFR, WatC is involved in MTX binding by forming hydrogen bonds to the ligand and protein, while WatD stabilizes WatC by hydrogen bonding to it and the protein.	Hydrogen	75-83	dihydrofolate reductase	Homo sapiens	25-30
7707376-6	1995	In crystal structures of hDHFR, WatC is involved in MTX binding by forming hydrogen bonds to the ligand and protein, while WatD stabilizes WatC by hydrogen bonding to it and the protein.	Hydrogen	147-155	dihydrofolate reductase	Homo sapiens	25-30
7707376-11	1995	WatF forms hydrogen bonds bridging the cofactor and the protein in crystal structures of hDHFR.	Hydrogen	11-19	dihydrofolate reductase	Homo sapiens	89-94
7880831-0	1995	2-Amino-3-ketobutyrate-CoA ligase from beef liver mitochondria: an NMR spectroscopic study of low-barrier hydrogen bonds of a pyridoxal 5"-phosphate-dependent enzyme.	Hydrogen	106-114	glycine C-acetyltransferase	Homo sapiens	0-33
7880831-1	1995	A study of protons associated with low-barrier hydrogen bonds in 2-amino-3-ketobutyrate-CoA ligase (AKB-ligase, EC 2.3.1.29) by NMR is reported.	Hydrogen	47-55	glycine C-acetyltransferase	Homo sapiens	65-98
7880831-1	1995	A study of protons associated with low-barrier hydrogen bonds in 2-amino-3-ketobutyrate-CoA ligase (AKB-ligase, EC 2.3.1.29) by NMR is reported.	Hydrogen	47-55	glycine C-acetyltransferase	Homo sapiens	100-110
7880831-9	1995	The three low-barrier hydrogen bonds described in this report may serve to anchor the cofactor in the active site of 2-amino-3-ketobutyrate-CoA ligase.	Hydrogen	22-30	glycine C-acetyltransferase	Homo sapiens	117-150
28959817-0	2017	Noble-metal-free nickel phosphide modified CdS/C3N4 nanorods for dramatically enhanced photocatalytic hydrogen evolution under visible light irradiation.	Hydrogen	102-110	CDP-diacylglycerol synthase 1	Homo sapiens	43-46
7531499-4	1995	Isotope effects upon ds-cleavage have been observed when the C-4" hydrogen of either nucleotide involved in the ds-break was substituted with deuterium.	Hydrogen	66-74	complement C4A (Rodgers blood group)	Homo sapiens	61-64
7531499-6	1995	The results are consistent with a mechanism of ds-cleavage in which the pathways leading to ss- and ds-cleavage partition from a common intermediate subsequent to abstraction of the C-4" hydrogen from the first nucleotide involved in the cleavage.	Hydrogen	187-195	complement C4A (Rodgers blood group)	Homo sapiens	182-185
28959817-4	2017	When employed as a photocatalyst for water splitting, the obtained best composite (5% Ni2P-CdS/g-C3N4) displayed dramatically enhanced hydrogen evolution activity at the rate of 44 450 mumol h-1 g-1, which was about 27 times higher than that of pure CdS (1668 mumol h-1 g-1).	Hydrogen	135-143	CDP-diacylglycerol synthase 1	Homo sapiens	91-94
28959817-4	2017	When employed as a photocatalyst for water splitting, the obtained best composite (5% Ni2P-CdS/g-C3N4) displayed dramatically enhanced hydrogen evolution activity at the rate of 44 450 mumol h-1 g-1, which was about 27 times higher than that of pure CdS (1668 mumol h-1 g-1).	Hydrogen	135-143	CDP-diacylglycerol synthase 1	Homo sapiens	250-253
28838832-6	2017	In mice inoculated with BxPC3-luc (PDGFRbeta-positive), the tumor uptake of radioactivity at 1h after the injection of [125I]IIQP was significantly higher than that after the injection of [125I]IB-IQP.	Hydrogen	93-95	platelet derived growth factor receptor, beta polypeptide	Mus musculus	35-44
7798941-6	1995	We add a new assignment to the 1H(13C) NMR spectroscopy, as acetate C-2 was detected in slice preparations from 5-week-old animals.	Hydrogen	31-33	complement C2	Rattus norvegicus	68-71
7999755-0	1994	Spectroscopic study of Ser92 mutants of human myoglobin: hydrogen bonding effect of Ser92 to proximal His93 on structure and property of myoglobin.	Hydrogen	57-65	myoglobin	Homo sapiens	46-55
7999755-0	1994	Spectroscopic study of Ser92 mutants of human myoglobin: hydrogen bonding effect of Ser92 to proximal His93 on structure and property of myoglobin.	Hydrogen	57-65	myoglobin	Homo sapiens	137-146
28873083-10	2017	Molecular docking revealed that SKLB188 could bind to the kinase domain of EGFR through hydrogen bonds and hydrophobic interactions.	Hydrogen	88-96	epidermal growth factor receptor	Mus musculus	75-79
7999755-1	1994	Neutron diffraction studies have demonstrated that the hydroxyl group oxygen of Ser92(F7) is hydrogen bonded to the proximal His93(48) N epsilon H proton in myoglobin (Mb) [Cheng, X., &amp; Shoenborn, B. P. (1991) J. Mol.	Hydrogen	93-101	myoglobin	Homo sapiens	157-166
7990955-1	1994	The conformation of a three-disulphide derivative of bovine alpha-lactalbumin bound to the molecular chaperone GroEL has been investigated by monitoring directly its hydrogen exchange kinetics using electrospray ionization mass spectrometry.	Hydrogen	166-174	lactalbumin alpha	Bos taurus	60-77
7990129-11	1994	The binding loop of CsA (residues 1 to 3 and 9 to 11) comprising 42% of the CsA surface, is buried in the peptidyl-prolyl-cis-trans isomerase active site of the cognate binding partner CypA, while the effector loop (residues 4 to 8) packs in the core of the decamer making hydrogen-bonding and van der Waals contacts with three neighbouring molecules.	Hydrogen	273-281	peptidylprolyl isomerase A	Homo sapiens	185-189
7866747-8	1994	The protein-CsA interactions in both the Fab and CypA complexes involve five hydrogen bonds, and the buried CsA surface areas are 395 A2 and 300 A2, respectively.	Hydrogen	77-85	FA complementation group B	Homo sapiens	41-44
7866747-8	1994	The protein-CsA interactions in both the Fab and CypA complexes involve five hydrogen bonds, and the buried CsA surface areas are 395 A2 and 300 A2, respectively.	Hydrogen	77-85	peptidylprolyl isomerase A	Homo sapiens	49-53
28681474-6	2017	DFT calculations show that a simple molecular model consisting of an imidazole Ndelta atom in a hydrogen-bond interaction with a MSK radical anion satisfactorily accounts for the available spectroscopic data.	Hydrogen	96-104	salt inducible kinase 1	Homo sapiens	129-132
7918422-0	1994	Studies of protein-protein association between yeast cytochrome c peroxidase and yeast iso-1 ferricytochrome c by hydrogen-deuterium exchange labeling and proton NMR spectroscopy.	Hydrogen	114-122	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	87-92
7937896-0	1994	Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant.	Hydrogen	76-84	thioredoxin	Homo sapiens	125-136
7937896-1	1994	Thioredoxin (Trx) and glutaredoxin (Grx1) are hydrogen donors for ribonucleotide reductase, the key enzyme for deoxyribonucleotide biosynthesis.	Hydrogen	46-54	thioredoxin	Homo sapiens	0-11
7937896-1	1994	Thioredoxin (Trx) and glutaredoxin (Grx1) are hydrogen donors for ribonucleotide reductase, the key enzyme for deoxyribonucleotide biosynthesis.	Hydrogen	46-54	thioredoxin	Homo sapiens	13-16
28681474-7	2017	These results support our previously proposed one-sided binding model for MSK to NarGHI through a single short hydrogen bond to the Ndelta of His66, one of the distal heme axial ligands.	Hydrogen	111-119	salt inducible kinase 1	Homo sapiens	74-77
7937896-2	1994	The viability of a double mutant lacking both Trx and Grx1 implies the presence of a third, unknown hydrogen donor.	Hydrogen	100-108	thioredoxin	Homo sapiens	46-49
7937896-8	1994	The low hydrogen donor activity for ribonucleotide reductase in the crude extract was recovered in the purification of Grx3, whereas Grx2 was inactive.	Hydrogen	8-16	glutaredoxin 3	Homo sapiens	119-123
28984574-3	2017	To address this deficit, we generated samples of a wild-type GPCR (A2AR) that are deuterated apart from 1H/13C NMR probes at isoleucine delta1 methyl groups, which facilitated 1H/13C methyl TROSY NMR measurements with opposing ligands.	Hydrogen	176-178	adenosine A2a receptor	Homo sapiens	67-71
7937896-9	1994	As a hydrogen donor for E. coli ribonucleotide reductase, Grx3 showed approximately the same Km value (0.35 microM) as Grx1, whereas its Vmax value was only 5% that of Grx1.	Hydrogen	5-13	glutaredoxin 3	Homo sapiens	58-62
7937896-10	1994	The combination of the Grx3 hydrogen donor activity and a 25-fold induction of ribonucleotide reductase activity in a delta trxA, grx double mutant provides an explanation for its viability and deoxyribonucleotide biosynthesis.	Hydrogen	28-36	glutaredoxin 3	Homo sapiens	23-27
28978782-4	2017	The compound crystallizes in the space group Pbca and forms a structure with strong hydrogen bonds connecting phosphate tetrahedra that agrees well with the IR spectra.	Hydrogen	84-92	PBCA	Homo sapiens	45-49
28831766-5	2017	In a first step towards the characterization of the Neurofibromin Spred1 interface in solution we assigned backbone and side chain 1H, 13C, and 15N chemical shifts of the Spred1 derived EVH1 domain.	Hydrogen	131-133	sprouty related EVH1 domain containing 1	Homo sapiens	66-72
7929110-3	1994	Since thioredoxin is a hydrogen donor to ribonucleotide reductase, a priori the inhibition of DNA synthesis was predicted to be caused by a reduction in the deoxyribonucleotide pools.	Hydrogen	23-31	thioredoxin	Homo sapiens	6-17
28743498-6	2017	Here, we report that hydrogen-rich medium activated LKB1-AMPK signal pathway without ATP depletion, which in turn induced FoxO1-dependent transcription of manganese superoxide dismutase and catalase in mouse embryonic fibroblasts.	Hydrogen	21-29	forkhead box O1	Mus musculus	122-127
8090735-5	1994	The guest molecule is bound by the R-state monomer through the formation of two hydrogen bonds from the hydroxy group of Tylenol to the carbonyl oxygen and the nitrogen of A6 Cys and A11 Cys, respectively.	Hydrogen	80-88	DXS435E	Homo sapiens	183-186
28743498-8	2017	These results suggest that the LKB1-AMPK-FoxO1 signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.	Hydrogen	121-123	forkhead box O1	Mus musculus	41-46
28743498-8	2017	These results suggest that the LKB1-AMPK-FoxO1 signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.	Hydrogen	158-160	forkhead box O1	Mus musculus	41-46
7919952-0	1994	Solution structure by 1H and dynamics by natural abundance 13C NMR of a receptor recognising peptide derived from a C-terminal fragment of neuropeptide Y.	Hydrogen	22-24	neuropeptide Y	Homo sapiens	139-153
28815973-8	2017	A comparison of the reaction kinetics on GaPd2 with experimental results obtained for GaPd reveals different orders of reaction of H2 and C2 H2 on the two compounds.	Hydrogen	131-133	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Homo sapiens	41-46
28815973-8	2017	A comparison of the reaction kinetics on GaPd2 with experimental results obtained for GaPd reveals different orders of reaction of H2 and C2 H2 on the two compounds.	Hydrogen	141-143	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Homo sapiens	41-46
8075536-2	1994	Using 15N- and 13C-resolved three- and four-dimensional [1H,1H]-nuclear Overhauser enhancement (NOE) spectroscopy with uniformly isotope-labeled Cyp in the complex, a final data set of 1810 intra-Cyp, 107 intra-CsA and 63 intermolecular NOE upper distance constraints was collected as input for the structure calculation with the program DIANA.	Hydrogen	57-59	peptidylprolyl isomerase G	Homo sapiens	145-148
8075536-2	1994	Using 15N- and 13C-resolved three- and four-dimensional [1H,1H]-nuclear Overhauser enhancement (NOE) spectroscopy with uniformly isotope-labeled Cyp in the complex, a final data set of 1810 intra-Cyp, 107 intra-CsA and 63 intermolecular NOE upper distance constraints was collected as input for the structure calculation with the program DIANA.	Hydrogen	60-62	peptidylprolyl isomerase G	Homo sapiens	145-148
28575721-6	2017	Molecular docking studies using a homology model of 5-HT1A revealed that ligand 5b is stabilized mainly by hydrogen bonds to Ser190.	Hydrogen	107-115	5-hydroxytryptamine receptor 1A	Homo sapiens	52-58
8206982-0	1994	Null thioredoxin and glutaredoxin Escherichia coli K-12 mutants have no enhanced sensitivity to mutagens due to a new GSH-dependent hydrogen donor and high increases in ribonucleotide reductase activity.	Hydrogen	132-140	thioredoxin	Homo sapiens	5-16
8206982-1	1994	This work investigates whether a mutator phenotype is associated to the simultaneous deficiency in thioredoxin and glutaredoxin, the two known hydrogen donors of ribonucleotide reductase.	Hydrogen	143-151	thioredoxin	Homo sapiens	99-110
8206982-6	1994	The existence of a new glutathione-dependent hydrogen donor for ribonucleotide reductase and the high activity levels of this enzyme in trx-grx- defective cells could explain that thioredoxin and the first discovered glutaredoxin are not essential for deoxyribonucleotide synthesis, even under mutagenic stress.	Hydrogen	45-53	thioredoxin	Homo sapiens	136-139
8206982-6	1994	The existence of a new glutathione-dependent hydrogen donor for ribonucleotide reductase and the high activity levels of this enzyme in trx-grx- defective cells could explain that thioredoxin and the first discovered glutaredoxin are not essential for deoxyribonucleotide synthesis, even under mutagenic stress.	Hydrogen	45-53	thioredoxin	Homo sapiens	180-191
8204626-3	1994	Using quenched-flow and NMR methods, hydrogen exchange rates were measured for several individual amide protons in guanidine-denatured horse cytochrome c.	Hydrogen	37-45	cytochrome c, somatic	Equus caballus	141-153
28795606-6	2017	ELISA assay showed hydrogen-rich saline lowered the levels of pro-inflammatory cytokines (IL-8 and IL-6) and anti-inflammatory cytokine IL-10 in bronchoalveolar lavage fluid and serum of chronic obstructive pulmonary disease rats.	Hydrogen	19-27	interleukin 10	Rattus norvegicus	136-141
7951052-2	1994	The results indicate that ketamine, injected 1h before the surgical treatment, increases HSP70 cellular concentration in both ischemic and sham-operated animals.	Hydrogen	45-47	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	89-94
28779688-4	2017	The p.R183Q mutation was predicted to abolish hydrogen bonds between R183 residue and GDP molecule, destabilizing the inactive GDP-bound conformation of the Galphaq mutants.	Hydrogen	46-54	G protein subunit alpha q	Homo sapiens	157-164
8146161-1	1994	Oxidative stress of human skin fibroblasts by treatment with ultraviolet A (UVA) radiation has been shown to lead to an increase in levels of the heme catabolizing enzyme heme oxygenase 1 [heme, hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating), EC 1.14.99.3] and the iron storage protein ferritin.	Hydrogen	195-203	heme oxygenase 1	Homo sapiens	171-187
19375463-5	2009	Hypoxia (1h)/re-oxygenation (24h) have a detrimental effect upon cultured cells by increasing the pro-apoptotic, bax gene and protein expression.	Hydrogen	9-11	BCL2 associated X, apoptosis regulator	Rattus norvegicus	113-116
28795556-4	2017	Unexpected shortening (and, thus, strengthening) of the O-H   O C component of the bifurcated hydrogen bond upon the formation of the C O   H-X hydrogen bond was found experimentally, proved theoretically (MP2), and explained by a roundabout interaction of the H-donor (HX) and H-acceptor (C O) via the system of conjugated bonds.	Hydrogen	94-102	tryptase pseudogene 1	Homo sapiens	206-209
19627118-1	2009	Chiral trans-cyclohexanediamine-benzimidazole organocatalysts promote the conjugate addition of a wide variety of 1,3-dicarbonyl compounds such as malonates, ketoesters, and 1,3-diketones to nitroolefins in the presence of TFA as cocatalyst in toluene as solvent at rt or 0 degrees C. The Michael adducts are obtained in high yield and enantioselectivity, using the chiral 2-aminobenzimidazole 7b as hydrogen-bond-mediated chiral organocatalyst.	Hydrogen	400-408	coagulation factor III, tissue factor	Homo sapiens	223-226
8121412-10	1994	The determination of hydrogen uptake in these R. meliloti mutants revealed that only ORF6 and ureB are necessary for hydrogen uptake.	Hydrogen	21-29	hypothetical protein	Sinorhizobium meliloti	85-89
8121412-10	1994	The determination of hydrogen uptake in these R. meliloti mutants revealed that only ORF6 and ureB are necessary for hydrogen uptake.	Hydrogen	117-125	hypothetical protein	Sinorhizobium meliloti	85-89
28795556-4	2017	Unexpected shortening (and, thus, strengthening) of the O-H   O C component of the bifurcated hydrogen bond upon the formation of the C O   H-X hydrogen bond was found experimentally, proved theoretically (MP2), and explained by a roundabout interaction of the H-donor (HX) and H-acceptor (C O) via the system of conjugated bonds.	Hydrogen	144-152	tryptase pseudogene 1	Homo sapiens	206-209
28692195-4	2017	Fe-CoP/CC is also highly active for the hydrogen evolution reaction, capable of driving 10 mA cm-2 at an overpotential of only 175 mV in 0.1 m K-Bi.	Hydrogen	40-48	caspase recruitment domain family member 16	Homo sapiens	3-6
7907470-5	1994	The 1H/13C satellite resonances from glutamate C-4 and lactate C-3 in brain tissue were followed from 4 min onwards in the presence of 5 mM [1-13C]glucose.	Hydrogen	4-6	complement C4A (Rodgers blood group)	Homo sapiens	47-50
19380248-0	2009	1H NMR titration and quantum calculation for the inclusion complexes of cis-cyclooctene, cis, cis-1, 3-cyclooctadiene and cis, cis-1, 5-cyclooctadiene with beta-cyclodextrin.	Hydrogen	0-2	suppressor of cytokine signaling 1	Homo sapiens	94-99
19380248-0	2009	1H NMR titration and quantum calculation for the inclusion complexes of cis-cyclooctene, cis, cis-1, 3-cyclooctadiene and cis, cis-1, 5-cyclooctadiene with beta-cyclodextrin.	Hydrogen	0-2	suppressor of cytokine signaling 1	Homo sapiens	127-132
28797100-0	2017	Mapping the contact surfaces in the Lamin A:AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry.	Hydrogen	61-69	lamin A/C	Homo sapiens	36-43
19809664-1	2009	Potential energy surfaces for H(2) release from hydrazine interacting with borane, alane, diborane, dialane and borane-alane were constructed from MP2/aVTZ geometries and zero point energies with single point energies at the CCSD(T)/aug-cc-pVTZ level.	Hydrogen	30-34	tryptase pseudogene 1	Homo sapiens	147-150
8312245-6	1994	In OPRTase, this is determined by steric constraints and the position of hydrogen bond donors/acceptors of a solvent-inaccessible crevice where the orotate ring of bound OMP resides.	Hydrogen	73-81	uridine monophosphate synthetase	Homo sapiens	3-10
8288565-0	1994	1H NMR study of the solution molecular and electronic structure of engineered distal myoglobin His64(E7) Val/Val68(E11) His double mutant.	Hydrogen	0-2	myoglobin	Homo sapiens	85-94
28797100-0	2017	Mapping the contact surfaces in the Lamin A:AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry.	Hydrogen	61-69	eukaryotic translation elongation factor 1 epsilon 1	Homo sapiens	44-49
8289201-0	1994	FTIR spectral study of intramolecular hydrogen bonding in thromboxane A2 receptor agonist (U-46619), prostaglandin (PG)E2, PGD2, PGF2 alpha, prostacyclin receptor agonist (carbacyclin), and their related compounds in dilute CCl4 solution: structure-activity relationships.	Hydrogen	38-46	C-C motif chemokine ligand 4	Homo sapiens	224-228
8289201-1	1994	FTIR spectra measurements and full optimization curve analysis of their spectra were done to obtain parameters of the OH and C = O stretching vibration bands for intramolecular hydrogen bondings in thromboxane (TX)A2 receptor partial agonist (CTA2), prostaglandin (PG)E2, PGD2, PGF2 alpha, prostacyclin (PGI2) receptor agonist (carbacyclin), and their related compounds in dilute CCl4 solutions.	Hydrogen	177-185	C-C motif chemokine ligand 4	Homo sapiens	380-384
28797100-4	2017	Here we report solution-phase hydrogen/deuterium exchange (HDX) for AIMP3, LmnA, and AIMP3 in association with the LmnA C-terminus.	Hydrogen	30-38	eukaryotic translation elongation factor 1 epsilon 1	Homo sapiens	68-73
19588926-5	2009	In order to elucidate the mechanism of function of this antibody, we have mapped the region and critical residues involved in the recognition of FasL using a combination of homology modeling, immunoprecipitation, hydrogen-deuterium exchange mass spectrometry (H/DXMS), and alanine scanning site-directed mutagenesis.	Hydrogen	213-221	Fas ligand	Homo sapiens	145-149
28797100-4	2017	Here we report solution-phase hydrogen/deuterium exchange (HDX) for AIMP3, LmnA, and AIMP3 in association with the LmnA C-terminus.	Hydrogen	30-38	lamin A/C	Homo sapiens	75-79
19515557-3	2009	X-ray structure of inhibitor 7k bound to DPP-4 revealed a hydrogen bonding interaction with Q553.	Hydrogen	58-66	dipeptidyl peptidase 4	Homo sapiens	41-46
19586525-3	2009	RESULTS: We determined the 1H-NMR solution structure of the polypeptide encoded by exon 6 of JAG1 and spanning the C-terminal region of EGF1 and the entire EGF2.	Hydrogen	27-29	jagged canonical Notch ligand 1	Homo sapiens	93-97
8142894-8	1994	Despite the structural similarity of the binding sites of EF-Tu and p21, the strengths of the observed hydrogen bonds at the 6-keto and 2-amino positions vary substantially, by up to a factor of 2.	Hydrogen	103-111	H3 histone pseudogene 16	Homo sapiens	68-71
8105887-0	1993	1H resonance assignments and secondary structure of the 13.6 kDa glycosylated adhesion domain of human CD2.	Hydrogen	0-2	CD2 molecule	Homo sapiens	103-106
28797100-4	2017	Here we report solution-phase hydrogen/deuterium exchange (HDX) for AIMP3, LmnA, and AIMP3 in association with the LmnA C-terminus.	Hydrogen	30-38	eukaryotic translation elongation factor 1 epsilon 1	Homo sapiens	85-90
7804366-5	1993	This suggests that the tyrosine residue at position 97 in the VH CDR3 region is in a contact position in the B72.3/TAG72 antibody/antigen interaction, and that the terminal hydroxyl group of the position 97 tyrosine side-chain contributes hydrogen bonding to the TAG72 antigen, whereas the position 96 tyrosine side-chain does not.	Hydrogen	239-247	cerebellar degeneration-related 3	Mus musculus	65-69
28749491-1	2017	Highly efficient Pt-Fe/gamma-Al2O3 catalysts for preferential oxidation of CO in excess of H2 (CO-PROX) were prepared by utilizing single-atom Fe species as active sites for O2 activation, which exhibited high catalytic activity and selectivity from 25  C to 200  C, with the highest Pt specific rate of Pt-based catalysts for CO-PROX.	Hydrogen	91-93	pyruvate dehydrogenase complex component X	Homo sapiens	98-102
8399155-1	1993	Horse heart cytochrome c is one of a small number of proteins for which the folding pathway has been elucidated in structural detail by pulsed hydrogen exchange and NMR.	Hydrogen	143-151	cytochrome c, somatic	Equus caballus	12-24
8379930-3	1993	We show that a hydrogen bond to the C-3 position is involved in sugar binding for all three isoforms, but that the direction of this hydrogen bond is different in GLUT 2 from either GLUT 1, 3 or 4.	Hydrogen	133-141	solute carrier family 2 member 2 S homeolog	Xenopus laevis	163-169
8379930-4	1993	Hydrogen-bonding at the C-4 position is also involved in sugar recognition by all three isoforms, but we propose that in GLUT 3 this hydrogen bond plays a less significant role than in GLUT 2 and 4.	Hydrogen	0-8	solute carrier family 2 member 2 S homeolog	Xenopus laevis	185-197
19586525-3	2009	RESULTS: We determined the 1H-NMR solution structure of the polypeptide encoded by exon 6 of JAG1 and spanning the C-terminal region of EGF1 and the entire EGF2.	Hydrogen	27-29	G elongation factor mitochondrial 1	Homo sapiens	136-140
28749491-1	2017	Highly efficient Pt-Fe/gamma-Al2O3 catalysts for preferential oxidation of CO in excess of H2 (CO-PROX) were prepared by utilizing single-atom Fe species as active sites for O2 activation, which exhibited high catalytic activity and selectivity from 25  C to 200  C, with the highest Pt specific rate of Pt-based catalysts for CO-PROX.	Hydrogen	91-93	pyruvate dehydrogenase complex component X	Homo sapiens	330-334
19409881-7	2009	EGF increased Sp1 expression within 1h, which was inhibited by U0126.	Hydrogen	36-38	epidermal growth factor	Canis lupus familiaris	0-3
7690248-1	1993	Backbone dynamics of the major tacrolimus (FK506) binding protein (FKBP-12, 107 amino acids) have been studied using 15N relaxation data derived from proton-detected two-dimensional 1H-15N NMR spectroscopy.	Hydrogen	182-184	FKBP prolyl isomerase 1A pseudogene 1	Homo sapiens	67-74
28653526-6	2017	By the combination of experimental results with DFT calculations, we show that the origin of the enhanced performance of our (Co,Mo)-N-C catalyst seems to be provided by an improved hydrogen binding energy on one MeN4 site because of the presence of a second MeN4 site in its close vicinity, as investigated in detail for our most active (Co,Mo)-N-C catalyst.	Hydrogen	182-190	cyclin dependent kinase inhibitor 1B	Homo sapiens	213-217
8318892-9	1993	Hydrogen exchange rates measured by two-dimensional NMR for individual peptide NH protons, taken together with the CD spectrum of I, indicate that moderately stable helices are present in I at the locations of the A, G, and H helices of native myoglobin (Hughson, F.M., Wright, P.E., &amp; Baldwin, R.L., 1990, Science 249, 1544-1548).	Hydrogen	0-8	myoglobin	Homo sapiens	244-253
28653526-6	2017	By the combination of experimental results with DFT calculations, we show that the origin of the enhanced performance of our (Co,Mo)-N-C catalyst seems to be provided by an improved hydrogen binding energy on one MeN4 site because of the presence of a second MeN4 site in its close vicinity, as investigated in detail for our most active (Co,Mo)-N-C catalyst.	Hydrogen	182-190	cyclin dependent kinase inhibitor 1B	Homo sapiens	259-263
28671821-3	2017	Here, we have measured the time-resolved hydrogen/deuterium exchange (HDX) of a soluble TCR in the presence and absence of its cognate pMHC by mass spectrometry to delineate the impact of pMHC binding on solution-phase structural dynamics in the TCR.	Hydrogen	41-49	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	88-91
8510155-6	1993	In this close encounter the terminal G(10).C(11) base-pair of the symmetry related molecule hydrogen bonds to the G(4).C(17) base-pair forming a novel base-paired G(4)*(G10).C(11)) triplet, where G(4) is hydrogen bonded to both G(10) and C(11).	Hydrogen	92-100	cytokine like 1	Homo sapiens	119-124
8510155-6	1993	In this close encounter the terminal G(10).C(11) base-pair of the symmetry related molecule hydrogen bonds to the G(4).C(17) base-pair forming a novel base-paired G(4)*(G10).C(11)) triplet, where G(4) is hydrogen bonded to both G(10) and C(11).	Hydrogen	204-212	cytokine like 1	Homo sapiens	119-124
8510155-7	1993	To facilitate this hydrogen bonding the G(4).C(17) base-pair slides into the minor groove, causing a toll on the backbone conformation of the adjacent residue G(5).	Hydrogen	19-27	cytokine like 1	Homo sapiens	45-50
28327425-10	2017	In-silico studies of the fetuin-A:Dox complex suggest that the drug binds in the major grove between beta-sheet and long loop region of D1 domain and stabilized by several hydrogen bonds.	Hydrogen	172-180	alpha 2-HS glycoprotein	Bos taurus	25-33
8381663-7	1993	Utilizing hydrogen exchange trapping techniques, the slowly exchanging residues are identified at pH 2.0 in 50% ethanol and 50% TFE (A10-A15, A18, A19, A21, A24, and A39) and are found to be clustered on one region of the A-chain.	Hydrogen	10-18	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	133-136
27425598-6	2017	The analyses of MD simulations of Liprin-alpha bound GRIP1-PDZ6 dimer show considerable conformational differences than that of peptide-free dimer in terms of SASA, hydrogen bonding patterns, and along principal component 1 (PC1).	Hydrogen	165-173	glutamate receptor interacting protein 1	Homo sapiens	53-58
8444404-2	1993	Fatty acid analysis by gas-liquid chromatography-mass spectrometry (GC-MS) revealed that GST-P forms 1:1 complex with fatty acids, mostly palmitic acid or stearic acid, which were hardly isolated from the complex even through Lipidex 1,000 column chromatography at 37 degrees C. Temperature dependent analysis of 1H-NMR on the association between GST-P and fatty acids indicated that molecular motion of fatty acids were strongly restrained in a hydrophobic "pocket" below the temperature of protein denaturation.	Hydrogen	313-315	glutathione S-transferase pi 1	Homo sapiens	89-94
28669630-5	2017	Unique to Exon19:CIPC, three highly conserved polar residues, Asn341 of CIPC and Gln544 of the two Exon19 helices, are located at the mid-section of the coiled-coil bundle interior and form hydrogen bonds with each other.	Hydrogen	190-198	CLOCK interacting protein, circadian	Mus musculus	17-21
1285840-3	1992	As in other DHFR complexes, MTXT is interpreted as protonated at N(1) by Glu-30, and the 2-amino group is hydrogen bonded to a structurally conserved water which also interacts with Glu-30 and Thr-136.	Hydrogen	106-114	dihydrofolate reductase	Homo sapiens	12-16
1453445-2	1992	1H nuclear magnetic resonance studies of Dolabella met-cyano myoglobin have revealed that a guanidino NH proton of Arg-E10 is hydrogen-bonded to the Fe-bound CN-.	Hydrogen	0-2	myoglobin	Homo sapiens	61-70
1453445-2	1992	1H nuclear magnetic resonance studies of Dolabella met-cyano myoglobin have revealed that a guanidino NH proton of Arg-E10 is hydrogen-bonded to the Fe-bound CN-.	Hydrogen	126-134	myoglobin	Homo sapiens	61-70
1453445-3	1992	The role of Arg-E10 as a hydrogen-bond donor for Fe-bound ligand in the present myoglobin appears to be responsible for its relatively high ligand affinity.	Hydrogen	25-33	myoglobin	Homo sapiens	80-89
10046677-0	1992	Diffractive scattering of hydrogen dimers from LiF(001).	Hydrogen	26-34	LIF interleukin 6 family cytokine	Homo sapiens	47-50
28669630-5	2017	Unique to Exon19:CIPC, three highly conserved polar residues, Asn341 of CIPC and Gln544 of the two Exon19 helices, are located at the mid-section of the coiled-coil bundle interior and form hydrogen bonds with each other.	Hydrogen	190-198	CLOCK interacting protein, circadian	Mus musculus	72-76
28426997-5	2017	Further molecular dynamics simulation indicated that the hydrophobic interactions as well as the hydrogen bonds contributed to the high affinity of 9p to Hsp90.	Hydrogen	97-105	heat shock protein 90 alpha family class A member 1	Homo sapiens	154-159
1384698-1	1992	We have used hydrogen-exchange labeling detected by 2D NMR to study antibody-protein interactions for two monoclonal antibodies raised against horse cytochrome c.	Hydrogen	13-21	cytochrome c, somatic	Equus caballus	149-161
28747729-0	2017	Conformational preludes to the latency transition in PAI-1 as determined by atomistic computer simulations and hydrogen/deuterium-exchange mass spectrometry.	Hydrogen	111-119	serpin family E member 1	Homo sapiens	53-58
1337000-1	1992	1H alpha, 13C alpha, and 15N alpha secondary shifts, defined as the difference between the observed value and the random coil value, have been calculated for interleukin-1 receptor antagonist protein and interleukin-1 beta.	Hydrogen	0-2	interleukin 1 receptor antagonist	Homo sapiens	158-199
1337001-0	1992	Sequential assignment of the backbone nuclei (1H, 15N and 13C) of c-H-ras p21 (1-166).GDP using a novel 4D NMR strategy.	Hydrogen	46-48	H3 histone pseudogene 16	Homo sapiens	74-77
28747729-3	2017	We report the first multi-microsecond atomistic molecular dynamics simulations of PAI-1 and compare the data with experimental hydrogen/deuterium-exchange data (HDXMS).	Hydrogen	127-135	serpin family E member 1	Homo sapiens	82-87
28515318-4	2017	Here, using maleimide-functionalized lipid vesicles, we successfully generated membrane-resident HRas and evaluated its effect on PI3K signaling in lipid kinase assays and through analysis with hydrogen-deuterium exchange MS. We screened all class IA PI3K isoforms and found that HRas activates both p110alpha and p110delta isoforms but does not activate p110beta.	Hydrogen	194-202	HRas proto-oncogene, GTPase	Homo sapiens	97-101
28728239-0	2017	[Effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells of allergic rhinitis guinea pigs model].	Hydrogen	11-19	T-cell surface glycoprotein CD4	Cavia porcellus	39-42
1326054-6	1992	Modification of hydrogen bonding and protein packing without disrupting the protein fold is illustrated by the His26Asn and Asn63Ser substitutions between iso-1 and iso-2-cytochromes c. Alternatively, a change in main-chain fold is observed at Gly37 apparently due to a remote amino acid substitution.	Hydrogen	16-24	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	155-160
28728239-1	2017	Objective: To explore the effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells in a guinea pig model of allergic rhinitis (AR) and investigate the underling anti-inflammatory mechanism.	Hydrogen	36-44	T-cell surface glycoprotein CD4	Cavia porcellus	64-67
27878567-2	2017	Peficitinib and its major metabolite H2 inhibit the hepatic uptake transporter organic anion transporting polypeptide 1B1 (OATP1B1) in vitro.	Hydrogen	37-39	solute carrier organic anion transporter family member 1B1	Homo sapiens	79-121
1511481-5	1992	On the other hand, HS-induced unlike DEX-induced apoptosis was not inhibited by protein synthesis and mRNA transcription inhibitors, the PKC inhibitors H-7 and staurosporine, or interleukin-4 (IL-4), but only by Zn2+.	Hydrogen	19-21	interleukin 4	Mus musculus	193-197
27878567-2	2017	Peficitinib and its major metabolite H2 inhibit the hepatic uptake transporter organic anion transporting polypeptide 1B1 (OATP1B1) in vitro.	Hydrogen	37-39	solute carrier organic anion transporter family member 1B1	Homo sapiens	123-130
27957768-1	2017	Here, we studied the influence of the methoxyl groups attached at C-7 and C-2" of natural and synthetic 1-arylindanes on the chemical shift of the signal of bibenzylic hydrogen and carbon atoms and J1,2 coupling constants.	Hydrogen	168-176	complement C2	Homo sapiens	74-77
1422155-0	1992	1H and 15N resonance assignments and secondary structure of the human thioredoxin C62A, C69A, C73A mutant.	Hydrogen	0-2	thioredoxin	Homo sapiens	70-81
1391721-1	1992	The effect of interleukin-1 alpha (IL-1) on the synthesis of glomerular basement membrane heparan sulfate-proteoglycan (HS-PG) was investigated.	Hydrogen	120-122	interleukin 1 alpha	Homo sapiens	35-39
28839371-11	2017	Berberine could bind to the ATP binding site of MLCK through hydrophobic effect and hydrogen bonding according to the docking study.	Hydrogen	84-92	myosin light chain kinase	Homo sapiens	48-52
28442430-6	2017	Here we describe the design and purification of PI3Kgamma constructs where flexible loops in the regulatory subunit have been removed based on structural information obtained by hydrogen/deuterium exchange - mass spectrometry (HDX-MS).	Hydrogen	178-186	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	48-57
1321617-4	1992	The results lead to the conclusion that the hydroxyl radical formed in Fe(II)-elsamicin A plus dithiothreitol system oxidizes the deoxyribose moiety via hydrogen abstraction predominantly at the C-4" carbon of the deoxyribose backbone and ultimately produces strand breakage of DNA.	Hydrogen	153-161	complement C4A (Rodgers blood group)	Homo sapiens	195-198
28621794-0	2017	Exploring surface landscapes with molecules: rotationally induced diffraction of H2 on LiF(001) under fast grazing incidence conditions.	Hydrogen	81-83	LIF interleukin 6 family cytokine	Homo sapiens	87-90
1378067-12	1992	This parallelism correlates with the similar role of Tyr59 and Tyr171 in establishing hydrogen bonds with the amino termini of HLA-B27-bound peptides.	Hydrogen	86-94	major histocompatibility complex, class I, B	Homo sapiens	127-134
28621794-3	2017	Using the LiF(001) surface as a benchmark, we show that fast grazing incidence diffraction of H2 strongly depends on the initial rotational state of the molecule, while rotationally inelastic processes are irrelevant.	Hydrogen	94-96	LIF interleukin 6 family cytokine	Homo sapiens	10-13
27782307-4	2017	In the present study relative free energies of binding are estimated for one or two non-hydrogen atom changes in compounds targeting the proteins ACK1 and p38 MAP kinase using three methods.	Hydrogen	88-96	tyrosine kinase non receptor 2	Homo sapiens	146-150
1610817-3	1992	The guanidinium NH2 nitrogen of Arg 44 forms one hydrogen bond to the imide nitrogen and a second to the carbonyl oxygen of Pro 66 in wild-type DHFR.	Hydrogen	49-57	Dihydrofolate reductase	Escherichia coli	144-148
1606151-1	1992	The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements.	Hydrogen	170-172	Calmodulin	Drosophila melanogaster	65-75
28272630-2	2017	The H2 production rates are dependent on the Pt-loading level, and the optimum production rate in the Pt/CdS/TNTs is approximately six times higher than that in Pt/CdS/TiO2.	Hydrogen	4-6	CDP-diacylglycerol synthase 1	Homo sapiens	105-108
28272630-2	2017	The H2 production rates are dependent on the Pt-loading level, and the optimum production rate in the Pt/CdS/TNTs is approximately six times higher than that in Pt/CdS/TiO2.	Hydrogen	4-6	troponin T1, slow skeletal type	Homo sapiens	109-113
1593628-2	1992	The comparison was based on complete sequence-specific 1H nuclear magnetic resonance assignments for human [Zn7]-metallothionein-2 obtained using the sequential assignment method.	Hydrogen	55-57	metallothionein 2A	Homo sapiens	113-130
1593628-5	1992	Finally, the 1H-1H distance constraints determined from nuclear Overhauser enhancement spectroscopy for human [Zn7]-metallothionein-2 were checked for compatibility with the [Cd7]-metallothionein-2 structure.	Hydrogen	13-15	metallothionein 2A	Homo sapiens	116-133
28272630-2	2017	The H2 production rates are dependent on the Pt-loading level, and the optimum production rate in the Pt/CdS/TNTs is approximately six times higher than that in Pt/CdS/TiO2.	Hydrogen	4-6	CDP-diacylglycerol synthase 1	Homo sapiens	164-167
1593628-5	1992	Finally, the 1H-1H distance constraints determined from nuclear Overhauser enhancement spectroscopy for human [Zn7]-metallothionein-2 were checked for compatibility with the [Cd7]-metallothionein-2 structure.	Hydrogen	16-18	metallothionein 2A	Homo sapiens	116-133
28272630-4	2017	This indicates that the Pt/CdS/TNTs composites enable H2 production via true water splitting under our typical experimental conditions.	Hydrogen	54-56	CDP-diacylglycerol synthase 1	Homo sapiens	27-30
28272630-4	2017	This indicates that the Pt/CdS/TNTs composites enable H2 production via true water splitting under our typical experimental conditions.	Hydrogen	54-56	troponin T1, slow skeletal type	Homo sapiens	31-35
28272630-6	2017	In addition, photocorrosion of CdS (i.e., sulfate formation) is significantly inhibited during the photocatalytic H2 production reactions in the Pt/CdS/TNTs because of the efficient charge transfer via the TNTs framework.	Hydrogen	114-116	CDP-diacylglycerol synthase 1	Homo sapiens	31-34
21583461-2	2009	In the crystal, mol-ecules are linked by N-H O hydrogen bonds, leading to C(4) chains.	Hydrogen	47-55	complement C4A (Rodgers blood group)	Homo sapiens	74-78
1375171-1	1992	The complex of the immunosuppressant FK506 bound to FKBP-12 has been studied in solution using 1H and inverse-detected 13C NMR methods.	Hydrogen	95-97	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	52-59
28272630-6	2017	In addition, photocorrosion of CdS (i.e., sulfate formation) is significantly inhibited during the photocatalytic H2 production reactions in the Pt/CdS/TNTs because of the efficient charge transfer via the TNTs framework.	Hydrogen	114-116	CDP-diacylglycerol synthase 1	Homo sapiens	148-151
28272630-6	2017	In addition, photocorrosion of CdS (i.e., sulfate formation) is significantly inhibited during the photocatalytic H2 production reactions in the Pt/CdS/TNTs because of the efficient charge transfer via the TNTs framework.	Hydrogen	114-116	troponin T1, slow skeletal type	Homo sapiens	152-156
1555604-0	1992	Conformation of MgATP bound to nucleotidyl and phosphoryl transfer enzymes 1H-transferred NOE measurements on complexes of methionyl tRNA synthetase and pyruvate kinase.	Hydrogen	75-77	methionyl-tRNA synthetase 1	Homo sapiens	123-148
19523979-5	2009	A short exposure (1h) to cadmium (25-100 microM), followed by several hours of recovery, produced a predominant apoptotic mechanism of cell death, involving the mitochondrial intrinsic pathway, as evidenced by nuclear condensation, DNA fragmentation, bax integration into the outer mitochondrial membrane, cytochrome c release, and activation of caspases-9 and -3.	Hydrogen	18-20	caspase 9	Homo sapiens	346-363
28272630-6	2017	In addition, photocorrosion of CdS (i.e., sulfate formation) is significantly inhibited during the photocatalytic H2 production reactions in the Pt/CdS/TNTs because of the efficient charge transfer via the TNTs framework.	Hydrogen	114-116	troponin T1, slow skeletal type	Homo sapiens	206-210
1555604-1	1992	The conformations of MgATP bound to a nucleotidyl transfer enzyme, methionyl tRNA synthetase and a phosphoryl transfer enzyme, pyruvate kinase, were studied by transferred NOE (TRNOE) measurements in 1H NMR.	Hydrogen	200-202	methionyl-tRNA synthetase 1	Homo sapiens	67-92
28471063-2	2017	This biomolecule-derived binary carbon nitride polymer enables the generation of energized charge carrier with light-irradiation to induce photoredox reactions for stable hydrogen production and heterogeneous organosynthesis of C-O, C-C, C-N and N-N bonds, which may enrich discussion on chemical reactions in prebiotic conditions by taking account of the photoredox function of conjugated carbonitride semiconductors that have long been considered to be stable HCN-derived organic macromolecules in space.	Hydrogen	171-179	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	462-465
1372979-9	1992	The predictions from this method are compared to known hydrogen positions for bovine pancreatic trypsin inhibitor, insulin, RNase-A, and trypsin for which the neutron diffraction structures have been determined.	Hydrogen	55-63	insulin	Bos taurus	115-122
19459629-6	2009	Upon irradiation at lambda &gt; 399 nm, triplet 1 undergoes photochemical 1,2-hydrogen migration to form hex-1-ene-3,5-diyne (6).	Hydrogen	78-86	exonuclease 1	Homo sapiens	105-110
28394487-0	2017	Graphene Decorated with Uniform Ultrathin (CoP)x -(FeP)1-x Nanorods: A Robust Non-Noble-Metal Catalyst for Hydrogen Evolution.	Hydrogen	107-115	caspase recruitment domain family member 16	Homo sapiens	43-46
1731923-1	1992	The interaction of mouse epidermal growth factor (mEGF) with micelles of a phospholipid analogue, perdeuterated dodecylphosphocholine (DPC), was investigated by two-dimensional 1H NMR.	Hydrogen	177-179	epidermal growth factor	Mus musculus	50-54
28487917-3	2017	An Fe-doped CoP nanosheet array (Fe-CoP/CC) is used as a bifunctional catalyst for both AOR and hydrogen evolution reaction (HER).	Hydrogen	96-104	caspase recruitment domain family member 16	Homo sapiens	12-15
1730227-0	1992	The identification of cation-binding domains on the surface of microsomal cytochrome b5 using 1H-NMR paramagnetic difference spectroscopy.	Hydrogen	94-96	cytochrome b5 type A	Homo sapiens	74-87
1730227-1	1992	One-dimensional and two-dimensional 1H-NMR methods and paramagnetic difference spectroscopy have defined cation binding domains on the surface of the tryptic fragment of microsomal cytochrome b5.	Hydrogen	36-38	cytochrome b5 type A	Homo sapiens	181-194
28497825-0	2017	Enhanced photocatalytic hydrogen evolution from in situ formation of few-layered MoS2/CdS nanosheet-based van der Waals heterostructures.	Hydrogen	24-32	CDP-diacylglycerol synthase 1	Homo sapiens	86-89
1289776-3	1992	Probably, the bulky moiety hinders the abstraction of hydrogen atom from deoxyribose by the C-1 carbon radical of phenylene diradical.	Hydrogen	54-62	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	92-95
1631043-4	1992	Specific residues involved in hydrogen bonds or salt interactions with dithionite include His116 and His117 of the beta 2 subunit and Lys16 of the alpha 1 subunit of the adjacent hemoglobin molecule.	Hydrogen	30-38	adrenoceptor alpha 1D	Homo sapiens	147-154
28251821-6	2017	KCC-1-supported TiO2 is a superior photocatalyst in terms of H2 generation (26.4 mmol gTiO2 -1  h-1 ) under UV light.	Hydrogen	61-63	solute carrier family 12 member 4	Homo sapiens	0-5
1743298-0	1991	1H, 13C and 15N backbone assignments of cyclophilin when bound to cyclosporin A (CsA) and preliminary structural characterization of the CsA binding site.	Hydrogen	0-2	peptidylprolyl isomerase G	Homo sapiens	40-51
28334993-5	2017	The effect of Asp268 on the oxoG excision was demonstrated with 1H NMR for WT hOGG1 and the hOGG1(D268N) mutant: the excision of oxoG was notably suppressed when Asp268 was mutated to Asn.	Hydrogen	64-66	8-oxoguanine DNA glycosylase	Homo sapiens	78-83
1685465-4	1991	Withdrawal of H2 blockade resulted in a significant rise in median nocturnal integrated intragastric acidity in 42 of 46 subjects (+36%; 95% CI +19, +55%) compared with prestudy values, but this rise was not associated with a significant change in the median integrated plasma gastrin concentration (+1%; 95% CI -12, +13%).	Hydrogen	14-16	gastrin	Homo sapiens	277-284
28334993-5	2017	The effect of Asp268 on the oxoG excision was demonstrated with 1H NMR for WT hOGG1 and the hOGG1(D268N) mutant: the excision of oxoG was notably suppressed when Asp268 was mutated to Asn.	Hydrogen	64-66	8-oxoguanine DNA glycosylase	Homo sapiens	92-97
28443336-0	2017	MoP/Mo2C@C: A New Combination of Electrocatalysts for Highly Efficient Hydrogen Evolution over the Entire pH Range.	Hydrogen	71-79	opioid receptor mu 1	Homo sapiens	0-3
1909892-0	1991	Secondary structure and side-chain 1H and 13C resonance assignments of calmodulin in solution by heteronuclear multidimensional NMR spectroscopy.	Hydrogen	35-37	Calmodulin	Drosophila melanogaster	71-81
28440366-4	2017	The driving force for the interfacial localization of most CB particles is the hydrogen bonding of CB with both TPU and COPA, which is confirmed by FTIR and DMA investigations.	Hydrogen	79-87	COPI coat complex subunit alpha	Homo sapiens	120-124
1790297-4	1991	The Pro1-Pro2 peptide bond is cis and the molecular conformation is stabilized by an intramolecular hydrogen bond between the CO group of the beta-Ala5 and the NH of the Phe3 residue.	Hydrogen	100-108	lamin A/C	Homo sapiens	4-8
2052613-1	1991	Catalytic activity of heme oxygenase (heme, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.3) isozymes, HO-1 and HO-2, permits production of physiologic isomers of bile pigments.	Hydrogen	44-52	heme oxygenase 1	Homo sapiens	106-119
28363522-12	2017	Furthermore, molecular docking revealed that POPs with P-gp modulatory effect bound to P-gp and fitted well into the cavity between the alpha and beta subunit of P-gp via forming hydrogen bonds.	Hydrogen	179-187	phosphoglycolate phosphatase	Homo sapiens	55-59
28363522-12	2017	Furthermore, molecular docking revealed that POPs with P-gp modulatory effect bound to P-gp and fitted well into the cavity between the alpha and beta subunit of P-gp via forming hydrogen bonds.	Hydrogen	179-187	phosphoglycolate phosphatase	Homo sapiens	87-91
2033049-11	1991	We propose that Nph and Nph2 as intermediates are held in the active site by hydrogen bonds and by two strong electrostatic interactions.	Hydrogen	77-85	neurexophilin 2	Homo sapiens	24-28
28363522-12	2017	Furthermore, molecular docking revealed that POPs with P-gp modulatory effect bound to P-gp and fitted well into the cavity between the alpha and beta subunit of P-gp via forming hydrogen bonds.	Hydrogen	179-187	phosphoglycolate phosphatase	Homo sapiens	87-91
28363677-4	2017	Using crosslinking, hydrogen exchange mass spectrometry, and fluorescence experiments, we demonstrate here that the N-terminal domain of Hsp90 rotates by approximately 180  as compared to the crystal structure of yeast Hsp90 in complex with Sba1 and AMPPNP.	Hydrogen	20-28	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	137-142
2029904-7	1991	epsilon-Methyl groups of Met120 and Met122 have been assigned by comparing 1H-NMR spectra of adrenodoxin with those of the trypsin-resistant form of adrenodoxin which is specifically cleaved at Arg115.	Hydrogen	75-77	adrenodoxin	Ovis aries	93-104
28327740-6	2017	Binding of PD-L1 accelerates the open-to-closed switch and locks the loop in the closed state through four newly formed intermolecular hydrogen bonds.	Hydrogen	135-143	CD274 molecule	Homo sapiens	11-16
2029904-7	1991	epsilon-Methyl groups of Met120 and Met122 have been assigned by comparing 1H-NMR spectra of adrenodoxin with those of the trypsin-resistant form of adrenodoxin which is specifically cleaved at Arg115.	Hydrogen	75-77	adrenodoxin	Ovis aries	149-160
28236743-5	2017	It was revealed that the Regorafenib can bind at the major groove-like stem region of miR-21 pre-element through three geometrically satisfactory hydrogen bonds (H-bonds) as well as a number of hydrophobic forces and pi-pi stacking, conferring strong specificity and high stability to the RNA-ligand complex system (Kd=0.73muM).	Hydrogen	146-154	microRNA 21	Homo sapiens	86-92
1900533-3	1991	The 1H NMR chemical shift of the C-4 hydrogen of pravadoline in comparison to the deshielding seen with 50, which lacks a substituent at C-2, suggested that the carbonyl group of pravadoline is located near C-2 but is located near C-4 in 50.	Hydrogen	37-45	complement component 4B (Chido blood group)	Mus musculus	33-36
28397087-2	2017	For this purpose, two hydrogen bonded complexes were selected: the HCN   HCN homodimer and the HCN   HF heterodimer.	Hydrogen	22-30	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	67-70
1825606-0	1991	Neocarzinostatin-induced hydrogen atom abstraction from C-4" and C-5" of the T residue at a d(GT) step in oligonucleotides: shuttling between deoxyribose attack sites based on isotope selection effects.	Hydrogen	25-33	complement C4A (Rodgers blood group)	Homo sapiens	56-59
1825606-2	1991	Substitution of deuterium for hydrogen at the C-4" position of the affected T leads to a kinetic isotope effect (kH/kD) of 4.0 on the formation of the glycolate-ended product, whereas deuterium at C-5" of the same T reveals kH/kD of 1.6 in the formation of the phosphate-ended product.	Hydrogen	30-38	complement C4A (Rodgers blood group)	Homo sapiens	46-49
1825606-2	1991	Substitution of deuterium for hydrogen at the C-4" position of the affected T leads to a kinetic isotope effect (kH/kD) of 4.0 on the formation of the glycolate-ended product, whereas deuterium at C-5" of the same T reveals kH/kD of 1.6 in the formation of the phosphate-ended product.	Hydrogen	30-38	complement C5	Homo sapiens	197-200
1991120-2	1991	The observed specificity energies [defined as delta delta G obs = -RT ln [(kcat/KM)first/(kcat/KM)second)]] of the substrate backbone hydrogen bonds were -2.7 kcal/mol for the P2 NH and -2.6 kcal/mol for the P1 NH when compared against substrates containing esters at those sites.	Hydrogen	134-142	prohibitin 2	Homo sapiens	176-188
28397087-2	2017	For this purpose, two hydrogen bonded complexes were selected: the HCN   HCN homodimer and the HCN   HF heterodimer.	Hydrogen	22-30	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	73-76
28397087-7	2017	Compared with experimental data, the calculated one-dimensional potential energy surface at the QCISD/aug-cc-pVDZ level of theory was found to predict the spectroscopic properties of hydrogen bonds better than the potential curves obtained using other computational methods, especially for the HCN   HCN homodimer complex.	Hydrogen	183-191	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	294-297
28397087-7	2017	Compared with experimental data, the calculated one-dimensional potential energy surface at the QCISD/aug-cc-pVDZ level of theory was found to predict the spectroscopic properties of hydrogen bonds better than the potential curves obtained using other computational methods, especially for the HCN   HCN homodimer complex.	Hydrogen	183-191	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	300-303
1849027-0	1991	Chemical exchange in two dimensions in the 1H NMR assignment of cytochrome c.	Hydrogen	43-45	cytochrome c, somatic	Equus caballus	64-76
1846303-4	1991	(1989) Biochemistry 28, 9579-9585] with muscle pyruvate kinase showed that the proton used for ketonization of enolpyruvate is derived from an enzyme "pool" that contains three kinetically equivalent hydrogens that could be trapped in a nontritiated "chase" medium by high levels of ADP and PEP.	Hydrogen	200-209	progestagen associated endometrial protein	Homo sapiens	291-294
28251489-8	2017	Molecular docking simulation predicted that eckol and dieckol exhibit higher binding affinity towards hMAO-A and hMAO-B through hydrogen bonding and hydrophobic interactions.	Hydrogen	128-136	monoamine oxidase A	Homo sapiens	102-108
1904297-3	1991	The purified receptor specifically bound the H2 selective ligand 3H-methyltiotidine with a kD of 160 nM (vs 50 nM for the intact HGT-1 cell) and a maximal binding capacity of 14,000 pmol/mg protein which represents a 12,170-fold enrichment and a degree of purity of 98%.	Hydrogen	45-47	solute carrier family 25 member 16	Homo sapiens	129-134
28232078-6	2017	The molecular docking calculations of compound 3 to c-MYC quadruplex corroborates with the 1H and NOESY NMR studies.	Hydrogen	91-93	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	52-57
28091961-0	2017	1H, 13C and 15N backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2.	Hydrogen	0-2	ubiquitin specific peptidase 1	Homo sapiens	73-76
1664016-5	1991	Their clinical importance is demonstrated by localized Larmor frequency-guided (LLFG) SENEX 1H images of the lumbar spine in healthy persons of different age and in a patient with acute myeloid leukemia.	Hydrogen	92-94	Rho GTPase activating protein 18	Homo sapiens	86-91
28243889-4	2017	Herein, we report the 1H, 13C, 15N main chain assignment of LTB from human isolates (hLTB; 103 a.a. per subunit, with a total molecular mass of 58.5 kDa).	Hydrogen	22-24	lymphotoxin beta	Homo sapiens	60-63
2176867-0	1990	Structural description of acid-denatured cytochrome c by hydrogen exchange and 2D NMR.	Hydrogen	57-65	cytochrome c, somatic	Equus caballus	41-53
28553512-0	2017	Sub-1.1 nm ultrathin porous CoP nanosheets with dominant reactive {200} facets: a high mass activity and efficient electrocatalyst for the hydrogen evolution reaction.	Hydrogen	139-147	caspase recruitment domain family member 16	Homo sapiens	28-31
20577496-0	1990	Two-photon excited LIF determination of H-atom concentrations near a heated filament in a low pressure H(2)environment.	Hydrogen	103-107	LIF interleukin 6 family cytokine	Homo sapiens	19-22
19385664-10	2009	As with wild-type Abeta, these peptides bind to the Fab via a combination of charge- and shape-complementarity, hydrogen-bonding, and hydrophobic interactions.	Hydrogen	112-120	FA complementation group B	Homo sapiens	52-55
28233979-5	2017	Four selected CdS microstructures are used as photocatalysts for the degradation of methylene blue and photoelectrochemical water splitting for hydrogen generation.	Hydrogen	144-152	CDP-diacylglycerol synthase 1	Homo sapiens	14-17
19382760-1	2009	Copper phthalate coordination polymers incorporating the kinked and hydrogen-bonding-capable imines 4,4"-dipyridylketone (dpk) and 4,4"-dipyridylamine (dpa) have been prepared and structurally characterized by single-crystal X-ray diffraction.	Hydrogen	68-76	potassium two pore domain channel subfamily K member 1	Homo sapiens	122-125
2203779-5	1990	One of the generally accepted mechanisms for the action of thioredoxin as a hydrogen donor involves a redox-active sulfhydryl group in the catalytic site of PAPS reductase.	Hydrogen	76-84	thioredoxin	Homo sapiens	59-70
2261466-0	1990	1H NMR assignment and secondary structure of the Ca2(+)-free form of the amino-terminal epidermal growth factor like domain in coagulation factor X.	Hydrogen	0-2	epidermal growth factor	Mus musculus	88-111
28206748-0	2017	Regulated Synthesis of Mo Sheets and Their Derivative MoX Sheets (X: P, S, or C) as Efficient Electrocatalysts for Hydrogen Evolution Reactions.	Hydrogen	115-123	monooxygenase DBH like 1	Homo sapiens	54-57
2166565-3	1990	The results for the Ca2 form are related to solvent accessibility and hydrogen bonding obtained in molecular dynamics simulations of calcium-loaded calbindin.	Hydrogen	70-78	calbindin 1	Homo sapiens	148-157
2166565-9	1990	Hydrogen bonds involving backbone NH"s in the Ca2+ loops appear to be broken or weakened when calbindin releases Ca2+, whereas the beta-sheet between the Ca2+ loops is found to be present in both the Ca2 and apo forms.	Hydrogen	0-8	calbindin 1	Homo sapiens	94-103
2166557-0	1990	Conformational studies of human [15-2-aminohexanoic acid]little gastrin in sodium dodecyl sulfate micelles by 1H NMR.	Hydrogen	110-112	gastrin	Homo sapiens	64-71
19413313-2	2009	Spectroscopic ((1)H NMR and IR) studies were used to probe the involvement of the C-2 hydrogen and the AcO(-) anion of [bmim][OAc] in the catalysis for O-t-Boc formation.	Hydrogen	86-94	complement C2	Homo sapiens	82-85
19440619-6	2009	The effect is discussed in terms of lattice dimerization involving hydrogen bonding between the anion layer and the conducting BEDT-TTF layer.	Hydrogen	67-75	ras homolog family member H	Homo sapiens	132-135
19420659-5	2009	Results indicate that higher degrees of Pd-carbon contacts for Pd particles embedded in a microporous carbon matrix induce efficient "pumping" of hydrogen out of beta- PdHx.	Hydrogen	146-154	pyruvate dehydrogenase complex component X	Homo sapiens	168-172
2166559-8	1990	One isomer was similar in stability to the sulfone, while the other was intermediate in stability between the sulfone and des-Met proteins, the differences potentially interpretable in terms of the geometry of the Met-1-Lys-63 hydrogen bond.	Hydrogen	227-235	granzyme M	Homo sapiens	214-219
28267793-3	2017	In this work, modeling analyses revealed that the phenylalanine F3.51 in CXCR6 might have impact on intramolecular interactions including hydrogen bonds by this possibly changing receptor function.	Hydrogen	138-146	C-X-C motif chemokine receptor 6	Homo sapiens	73-78
2332766-3	1990	The complexation of glutathione and related ligands by the nitrilotriacetic acid complex of Cd2+ (Cd(NTA)-) has been investigated by 1H NMR as a model for the coordination chemistry of Cd2+ and GSH in biological systems.	Hydrogen	133-135	CD2 molecule	Homo sapiens	92-95
19364645-8	2009	In conclusion, our data indicate that the absence of a hydrogen-bond donor on the C(6) oxygen enhances rather than impedes the in vitro affinity of naltrexol derivatives for the MOR.	Hydrogen	55-63	opioid receptor mu 1	Homo sapiens	178-181
27616456-5	2017	Molecular docking analysis revealed the existence of hydrophobic and hydrogen interactions between compound 5p and the active site of alpha-glucosidase.	Hydrogen	69-77	sucrase-isomaltase	Homo sapiens	134-151
19089469-1	2009	The unusual T-shaped X-H...pi hydrogen bonds are found between the B=B double bond of the singlet state HB=BH and the acid hydrogen of HF, HCl, HCN and H2C2 using MP2 and B3LYP methods at 6-311++G(2df,2p) and aug-cc-pVTZ levels.	Hydrogen	30-38	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	144-147
19089469-1	2009	The unusual T-shaped X-H...pi hydrogen bonds are found between the B=B double bond of the singlet state HB=BH and the acid hydrogen of HF, HCl, HCN and H2C2 using MP2 and B3LYP methods at 6-311++G(2df,2p) and aug-cc-pVTZ levels.	Hydrogen	30-38	tryptase pseudogene 1	Homo sapiens	163-166
19089469-1	2009	The unusual T-shaped X-H...pi hydrogen bonds are found between the B=B double bond of the singlet state HB=BH and the acid hydrogen of HF, HCl, HCN and H2C2 using MP2 and B3LYP methods at 6-311++G(2df,2p) and aug-cc-pVTZ levels.	Hydrogen	123-131	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	144-147
19089469-1	2009	The unusual T-shaped X-H...pi hydrogen bonds are found between the B=B double bond of the singlet state HB=BH and the acid hydrogen of HF, HCl, HCN and H2C2 using MP2 and B3LYP methods at 6-311++G(2df,2p) and aug-cc-pVTZ levels.	Hydrogen	123-131	tryptase pseudogene 1	Homo sapiens	163-166
2140051-6	1990	On the basis of the spectral properties of fluorinated analogues, a polar group in the chromophore binding site of iodopsin as well as rhodopsin was estimated to be located near the hydrogen atom at the C10 position of the retinylidene chromophore.	Hydrogen	182-190	opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)	Gallus gallus	115-123
2140051-6	1990	On the basis of the spectral properties of fluorinated analogues, a polar group in the chromophore binding site of iodopsin as well as rhodopsin was estimated to be located near the hydrogen atom at the C10 position of the retinylidene chromophore.	Hydrogen	182-190	rhodopsin	Bos taurus	135-144
2154849-1	1990	The complex formed in solution by native and chemically modified cytochrome c with cytochrome b5 has been studied by 1H and 13C nuclear magnetic resonance spectroscopy (NMR).	Hydrogen	117-119	cytochrome b5 type A	Homo sapiens	83-96
2334715-0	1990	Studies on the solution conformation of human thioredoxin using heteronuclear 15N-1H nuclear magnetic resonance spectroscopy.	Hydrogen	82-84	thioredoxin	Homo sapiens	46-57
2334715-1	1990	The solution conformation of uniformly labeled 15N human thioredoxin has been studied by two-dimensional heteronuclear 15N-1H nuclear magnetic resonance spectroscopy.	Hydrogen	123-125	thioredoxin	Homo sapiens	57-68
28098910-0	2017	Hydrogen-rich saline improves non-alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARalpha and PPARgamma.	Hydrogen	0-8	peroxisome proliferator activated receptor alpha	Rattus norvegicus	119-128
27780950-6	2017	We investigated the ability of nanoparticle hydrogen in water to suppress hydroxyurea-induced ROS production, cytotoxicity, and the accumulation of beta-galactosidase (an indicator of aging), and promote cell proliferation.	Hydrogen	44-52	galactosidase, beta 1	Mus musculus	148-166
2275983-0	1990	Synthesis and 1H-NMR studies of alpha-deuterated analogues of des-Trp1, Nle12-human minigastrin.	Hydrogen	14-16	tRNA-Pro (anticodon AGG) 2-5	Homo sapiens	66-70
2092960-4	1990	Experimental investigations of the Raman spectra of A10 and its N,N-dideuterated derivative confirm the theoretical predictions concerning the structure and hydrogen bonding of A10.	Hydrogen	157-165	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	52-55
2092960-4	1990	Experimental investigations of the Raman spectra of A10 and its N,N-dideuterated derivative confirm the theoretical predictions concerning the structure and hydrogen bonding of A10.	Hydrogen	157-165	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	177-180
2162313-3	1990	Thioredoxin reductase (TR) is a widely distributed flavoenzyme that provides reduced thioredoxin, a dithiol hydrogen donor for protein disulfide reduction and for the reduction of ribonucleotides to deoxyribonucleotides, the first unique step of DNA synthesis.	Hydrogen	108-116	peroxiredoxin 5	Homo sapiens	0-21
2162313-3	1990	Thioredoxin reductase (TR) is a widely distributed flavoenzyme that provides reduced thioredoxin, a dithiol hydrogen donor for protein disulfide reduction and for the reduction of ribonucleotides to deoxyribonucleotides, the first unique step of DNA synthesis.	Hydrogen	108-116	peroxiredoxin 5	Homo sapiens	23-25
2162313-3	1990	Thioredoxin reductase (TR) is a widely distributed flavoenzyme that provides reduced thioredoxin, a dithiol hydrogen donor for protein disulfide reduction and for the reduction of ribonucleotides to deoxyribonucleotides, the first unique step of DNA synthesis.	Hydrogen	108-116	thioredoxin	Homo sapiens	85-96
2332764-3	1990	Based on IR, 1H NMR, 13C NMR, and electronic spectral studies, distorted octahedral geometry with cis-MoO2 group has been indicated for the resulting complexes.	Hydrogen	13-15	modifier of obesity 2	Mus musculus	102-106
2125862-9	1990	The SP-LI, ENK-LI and FRAP were all weakened in dorsal horn of spinal cord 1h after capsaicin treatment.	Hydrogen	75-77	proenkephalin	Rattus norvegicus	11-14
33768678-5	2021	Previously, various oxidation reactions conducted on the anodic side of the electrolysis were paired with the generation and use of hydrogen gas at the cathode.	Hydrogen	132-140	gastrin	Homo sapiens	141-144
33773206-0	2021	Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.	Hydrogen	0-8	brain derived neurotrophic factor	Mus musculus	130-134
33821889-3	2021	Herein, the presence of redox-active DOPA residue in the active site of mutant Mb presumably stabilizes the compound I in the catalytic oxidation process by participating in an additional hydrogen bonding (H-bonding) as compared to the WT Mb.	Hydrogen	188-196	myoglobin	Homo sapiens	79-81
33821889-3	2021	Herein, the presence of redox-active DOPA residue in the active site of mutant Mb presumably stabilizes the compound I in the catalytic oxidation process by participating in an additional hydrogen bonding (H-bonding) as compared to the WT Mb.	Hydrogen	188-196	myoglobin	Homo sapiens	239-241
33822612-2	2021	Herein, we unravel that the fluorescence emission spectrum with a broad wavelength range (770-950 nm) of CAT-1 is primarily induced by hydrogen bond steric hindrance based on density functional theory and Marcus theory.	Hydrogen	135-143	GIT ArfGAP 1	Homo sapiens	105-110
33804322-8	2021	C3G could spontaneously bind with alpha-glucosidase to form complexes by hydrogen bonds.	Hydrogen	73-81	sucrase-isomaltase	Homo sapiens	34-51
33804322-11	2021	Molecular docking speculated that C3G could form hydrogen bonds with alpha-glucosidase by binding to the active sit (Leu 313, Ser 157, Tyr 158, Phe 314, Arg 315, and two Asp 307).	Hydrogen	49-57	sucrase-isomaltase	Homo sapiens	69-86
33814411-6	2021	The antioxidant effect of loading with water with saturation with molecular hydrogen leads to a decrease in the loss of sodium ions due to an improvement in its reabsorption and beta2-microglobulin in the proximal tubule, a decrease in lipid peroxidation in the renal cortex was noted, the degree of its damage by an increase in the K+/Na+ ratio and a decrease in degree of edema.	Hydrogen	76-84	beta-2 microglobulin	Rattus norvegicus	178-197
28894978-0	2018	Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-beta in Guinea Pigs.	Hydrogen	0-8	T-cell surface glycoprotein CD4	Cavia porcellus	110-113
28894978-0	2018	Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-beta in Guinea Pigs.	Hydrogen	0-8	interleukin-10	Cavia porcellus	145-159
28894978-3	2018	We herein aim to verify the protective effects of hydrogen on CD4+CD25+Foxp3+Treg cells in guinea pigs with AR and to explore the effect of hydrogen-rich saline (HRS) on CD4+CD25+Foxp3+Treg cells in animals with AR and investigate the underlying anti-inflammatory mechanism.	Hydrogen	50-58	T-cell surface glycoprotein CD4	Cavia porcellus	62-65
28894978-3	2018	We herein aim to verify the protective effects of hydrogen on CD4+CD25+Foxp3+Treg cells in guinea pigs with AR and to explore the effect of hydrogen-rich saline (HRS) on CD4+CD25+Foxp3+Treg cells in animals with AR and investigate the underlying anti-inflammatory mechanism.	Hydrogen	140-148	T-cell surface glycoprotein CD4	Cavia porcellus	170-173
25797482-8	2015	FT-IR analysis revealed that there were hydrogen bond interactions between the SP alone and SLN components.	Hydrogen	40-48	sarcolipin	Rattus norvegicus	92-95
34699915-6	2022	The functional groups from the amino acids, like CO, N-H and aromatic functional groups, are anticipated to further stabilize the insulin conformation by forming hydrogen bond and van der Waals interactions with the key amyloidogenic sequences of insulin, A13-A20 from A-chain and B9-B20 from B-chain.	Hydrogen	162-170	insulin	Bos taurus	130-137
34699915-6	2022	The functional groups from the amino acids, like CO, N-H and aromatic functional groups, are anticipated to further stabilize the insulin conformation by forming hydrogen bond and van der Waals interactions with the key amyloidogenic sequences of insulin, A13-A20 from A-chain and B9-B20 from B-chain.	Hydrogen	162-170	insulin	Bos taurus	247-254
34970349-12	2022	In addition the protein expression levels of RIP1 and RIP3 and the cytokines NF-kappaB, TNF-alpha, IL-1beta and IL-6 were downregulated compared with the TBI group, which demonstrated that hydrogen-rich saline-induced inhibition of necroptosis and neuroinflammation ameliorated neuronal death following TBI.	Hydrogen	189-197	interleukin 1 alpha	Mus musculus	99-107
34802943-3	2022	The results from fluorescence quenching and thermomechanical analyses signified that omeprazole reduced the fluorescence intensity of alpha-glucosidase by forming an omeprazole-alpha-glucosidase complex primarily driven by hydrogen bonds.	Hydrogen	223-231	sucrase-isomaltase	Homo sapiens	134-151
34802943-3	2022	The results from fluorescence quenching and thermomechanical analyses signified that omeprazole reduced the fluorescence intensity of alpha-glucosidase by forming an omeprazole-alpha-glucosidase complex primarily driven by hydrogen bonds.	Hydrogen	223-231	sucrase-isomaltase	Homo sapiens	177-194
34802943-4	2022	Molecular docking further confirmed that hydrogen bonds and hydrophobic forces were the major driving forces for omeprazole binding to alpha-glucosidase.	Hydrogen	41-49	sucrase-isomaltase	Homo sapiens	135-152
34955208-3	2022	The as-prepared CdS/C3N4 materials exhibit high efficiency for photocatalytic hydrogen evolution reaction (HER) with the HER rate as high as 15,866 mumol/(g hr) under visible light irradiation (lambda > 420 nm), which is 89 and 9 times those of pristine C3N4 and CdS, respectively.	Hydrogen	78-86	CDP-diacylglycerol synthase 1	Homo sapiens	263-266
34757082-0	2022	High concentration of hydrogen ameliorates lipopolysaccharide-induced acute lung injury in a sirt1-dependent manner.	Hydrogen	22-30	sirtuin 1	Mus musculus	93-98
34757082-3	2022	The pulmonary microvascular permeability and 66.7 % hydrogen on the expression of sirt1 and its downstream signaling molecules were tested.	Hydrogen	52-60	sirtuin 1	Mus musculus	82-87
34757082-5	2022	sirt1 contributed to the repair of LPS-induced ALI by hydrogen through the regulation of NF-kappaB and catalase expression.	Hydrogen	54-62	sirtuin 1	Mus musculus	0-5
34757082-6	2022	In conclusion, 66.7 % hydrogen protected against LPS-induced ALI by suppressing inflammatory response and oxidative stress mediated by NF-kappaB and catalase in a sirt1-dependent manner.	Hydrogen	22-30	sirtuin 1	Mus musculus	163-168
34962378-5	2022	Benefiting from the above superiorities of morphological and chemical compositions, this self-supported CoP@Fe-CoP/NC/NF heterostructure can drive alkaline hydrogen evolution reaction and oxygen evolution reaction with overpotentials of 97 and 270 mV to yield 100 mA cm-2, respectively.	Hydrogen	156-164	caspase recruitment domain family member 16	Homo sapiens	104-107
34962378-5	2022	Benefiting from the above superiorities of morphological and chemical compositions, this self-supported CoP@Fe-CoP/NC/NF heterostructure can drive alkaline hydrogen evolution reaction and oxygen evolution reaction with overpotentials of 97 and 270 mV to yield 100 mA cm-2, respectively.	Hydrogen	156-164	caspase recruitment domain family member 16	Homo sapiens	111-114
34793912-6	2022	Furthermore, computational study clarified the important contribution of the key amino acid residues Ser122, and Asp313 in CYP1A1, as well as Asp320 in CYP1A2 to the hydroxylation of CBZ through hydrogen bonds.	Hydrogen	195-203	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	123-129
34793912-6	2022	Furthermore, computational study clarified the important contribution of the key amino acid residues Ser122, and Asp313 in CYP1A1, as well as Asp320 in CYP1A2 to the hydroxylation of CBZ through hydrogen bonds.	Hydrogen	195-203	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	152-158
34910460-6	2022	Complexation with DBL1 or H33A alters the position of sMMOH residue R245, which is part of a conserved hydrogen-bonding network encompassing the active site diiron cluster where P is formed.	Hydrogen	103-111	H3.3 histone A	Homo sapiens	26-30
34825490-1	2022	The catalytic hydrogen-evolving activities of transition-metal phosphides are greatly related to the phosphorus content, but the physical origin of performance enhancement remains ambiguous, and tuning the catalytic activity of nickel phosphides (NiP2 /Ni5 P4 ) remains challenging due to unfavorable H* adsorption.	Hydrogen	14-22	BCL2 interacting protein 2	Homo sapiens	247-251
19275886-6	2009	Molecular dynamics simulations of the Tn-core containing these TnT mutants suggested that the hydrogen-bond network formed by the side chains of neighboring residues around residues 244 and 247 is important for Tn to function properly.	Hydrogen	94-102	troponin T1, slow skeletal type	Homo sapiens	63-66
19224862-4	2009	The crystal structure of the PCSK9-EGF-A(H306Y) complex shows that Tyr-306 forms a hydrogen bond with Asp-374 in PCSK9 at neutral pH, which strengthens the interaction with PCSK9.	Hydrogen	83-91	proprotein convertase subtilisin/kexin type 9	Homo sapiens	29-34
19224862-4	2009	The crystal structure of the PCSK9-EGF-A(H306Y) complex shows that Tyr-306 forms a hydrogen bond with Asp-374 in PCSK9 at neutral pH, which strengthens the interaction with PCSK9.	Hydrogen	83-91	proprotein convertase subtilisin/kexin type 9	Homo sapiens	113-118
19224862-4	2009	The crystal structure of the PCSK9-EGF-A(H306Y) complex shows that Tyr-306 forms a hydrogen bond with Asp-374 in PCSK9 at neutral pH, which strengthens the interaction with PCSK9.	Hydrogen	83-91	proprotein convertase subtilisin/kexin type 9	Homo sapiens	113-118
19351388-0	2009	In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment.	Hydrogen	8-10	amyloid beta (A4) precursor protein	Mus musculus	75-82
19243160-3	2009	Ab initio calculations at the MP2(Full)/6-311+G(2d,2p) and MP2(Full)/6-311+G(2df,2pd) levels for the fluorine and the hydrogen analogues, respectively, provided rotational constants, dipole moment components, and the relative energies of the conformers to assist in the spectral assignment.	Hydrogen	118-126	tryptase pseudogene 1	Homo sapiens	59-62
19162521-4	2009	It was found that the degradation of the dye was accelerated with increased concentrations of CCl(4) via the accumulation of reactive chlorine species and the hindrance of OH radical combination reactions with atomic hydrogen.	Hydrogen	217-225	C-C motif chemokine ligand 4	Homo sapiens	94-100
34825490-2	2022	Here, a strategy is introduced to integrate P-rich NiP2 and P-poor Ni5 P4 into in-plane heterostructures by anion substitution, in which P atoms at the in-plane interfaces perform as active sites to adsorb H* and thus facilitate the hydrogen evolution reaction (HER) process via modulating the electronic structure between NiP2 and Ni5 P4 .	Hydrogen	233-241	BCL2 interacting protein 2	Homo sapiens	51-55
34825490-2	2022	Here, a strategy is introduced to integrate P-rich NiP2 and P-poor Ni5 P4 into in-plane heterostructures by anion substitution, in which P atoms at the in-plane interfaces perform as active sites to adsorb H* and thus facilitate the hydrogen evolution reaction (HER) process via modulating the electronic structure between NiP2 and Ni5 P4 .	Hydrogen	233-241	BCL2 interacting protein 2	Homo sapiens	323-327
34825490-3	2022	Consequently, the NiP2 /Ni5 P4 hybrid exhibits an outstanding hydrogen-evolving activity, requiring only 30 and 76 mV to afford 10 and 100 mA cm-2 in acid, respectively.	Hydrogen	62-70	BCL2 interacting protein 2	Homo sapiens	18-22
34870367-0	2022	Directionally In Situ Self-Assembled, High-Density, Macropore-Oriented, CoP-Impregnated, 3D Hierarchical Porous Carbon Sheet Nanostructure for Superior Electrocatalysis in the Hydrogen Evolution Reaction.	Hydrogen	176-184	caspase recruitment domain family member 16	Homo sapiens	72-75
28264456-0	2017	Pt-Au/MOx-CeO2 (M = Mn, Fe, Ti) Catalysts for the Co-Oxidation of CO and H2 at Room Temperature.	Hydrogen	73-75	monooxygenase DBH like 1	Homo sapiens	6-9
34709042-0	2021	Solar-Driven Gas-Phase Moisture to Hydrogen with Zero Bias.	Hydrogen	35-43	gastrin	Homo sapiens	13-16
28264456-1	2017	A series of nanostructured Pt-Au/MOx-CeO2 (M = Mn, Fe, Ti) catalysts were prepared and their catalytic performance for the co-oxidation of carbon monoxide (CO) and hydrogen (H2) were evaluated at room temperature.	Hydrogen	164-172	monooxygenase DBH like 1	Homo sapiens	33-36
34709042-2	2021	Here, we explore the possibility of achieving a bias-free single-step solar to chemical energy conversion using gas-phase moisture as the reactant while generating hydrogen as the reaction product.	Hydrogen	164-172	gastrin	Homo sapiens	112-115
34898206-5	2021	They could bind to alpha-glucosidase through van der Waals forces and hydrogen bonds and quench its endofluorescence with a static quenching mechanism.	Hydrogen	70-78	sucrase-isomaltase	Homo sapiens	19-36
19185288-2	2009	NMR studies of several of the intermediates leading to the beta-1,3-glucan show anomalously small coupling constants for some of the C-1 hydrogens.	Hydrogen	137-146	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	133-136
28264456-4	2017	Temperature-programmed reduction of hydrogen (H2-TPR) and X-ray photoelectron spectroscopy (XPS) results suggested that MOx could improve the charge transfer from Au sites to CeO2, resulting in a high concentration of Ce3+ and cationic Au species which benefits for the CO oxidation.	Hydrogen	36-44	monooxygenase DBH like 1	Homo sapiens	120-123
34898206-7	2021	Molecular docking further indicated that a hydrogen bond was generated between OH at the C-3 position of 4,4-dimethylsterols and the alpha-glucosidase residue Arg-442.	Hydrogen	43-51	sucrase-isomaltase	Homo sapiens	133-150
28124825-1	2017	The photoinduced hydrogen evolution reaction (HER) by decamethylruthenocene, Cp2 *RuII (Cp*=C5 Me5 ), is reported.	Hydrogen	17-25	ceruloplasmin	Homo sapiens	77-80
34866382-0	2021	One-Pot Synthesis of One-Dimensional Multijunction Semiconductor Nanochains from Cu1.94S, CdS, and ZnS for Photocatalytic Hydrogen Generation.	Hydrogen	122-130	CDP-diacylglycerol synthase 1	Homo sapiens	90-93
19209363-18	2009	These compositions are promising candidates to test in a (PROX) fuel processor to supply purified (CO-free) H(2) to a PEM fuel cell.	Hydrogen	108-112	pyruvate dehydrogenase complex component X	Homo sapiens	58-62
28035004-6	2017	These structures based on high quality data showed that the base moieties of two substrates are located on the similar but not the same position in the substrate binding pocket and adopt a different hydrogen-bonding pattern, and both triphosphate moieties bind to the hMTH1 Nudix motif (i.e. the hydrolase motif) similarly and align for the hydrolysis reaction.	Hydrogen	199-207	nudix hydrolase 1	Homo sapiens	268-273
19206977-6	2009	MP2 level calculations revealed that the sigma-type (NH...O) hydrogen-bonded structures had 7.6-9.0 kJ/mol larger binding energies than the pi-type structures (OH...pi electron cloud of pyrrole), and that the vibrational frequencies of the sigma-type structures are consistent with the observed spectra.	Hydrogen	61-69	tryptase pseudogene 1	Homo sapiens	0-3
34624824-6	2021	The docking study revealed that the hydrogen bonds and cation-pi interaction between ligands and alpha-syn aggregates would be crucial for the activity.	Hydrogen	36-44	synuclein alpha	Homo sapiens	97-106
28074783-4	2017	The influence of the tip state on the probability for hydrogen removal was examined by comparing the desorption efficiency for various classifications of STM topographs (rows, dimers, atoms, etc).	Hydrogen	54-62	TOR signaling pathway regulator	Homo sapiens	21-24
34864923-6	2021	Degradation products, DP-1 and DP-2, were isolated and characterized by ESI-MS, 1H, NMR and 13C NMR spectroscopy.	Hydrogen	80-82	transcription factor Dp-2	Homo sapiens	31-35
28074783-5	2017	We find that dimer-row-resolving tip apices extract hydrogen atoms most readily and reliably (and with least spurious desorption), while tip states which provide atomic resolution counter-intuitively have a lower probability for single H atom removal.	Hydrogen	52-60	TOR signaling pathway regulator	Homo sapiens	33-36
34197982-4	2021	Because of the great enhanced spatial separation of photogenerated charge carriers, the CuS/KTN presents much higher performance than pure KNT, which is further confirmed by 1H NMR analysis of the reaction solution.	Hydrogen	174-176	kinectin 1	Homo sapiens	139-142
21581862-8	2009	The crystal structure is established by a two-dimensional network of O-H Cl and N-H Cl hydrogen bonds, generating C(1) (2)(4) and C(1) (2)(7) chains, and R(2) (4)(8) and R(2) (4)(14) rings.	Hydrogen	87-95	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	114-118
21581862-8	2009	The crystal structure is established by a two-dimensional network of O-H Cl and N-H Cl hydrogen bonds, generating C(1) (2)(4) and C(1) (2)(7) chains, and R(2) (4)(8) and R(2) (4)(14) rings.	Hydrogen	87-95	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	130-134
28110817-7	2017	The interaction between CQ and alpha-glucosidase depended on hydrogen bonds, electrostatic and hydrophobic force, while the driving force of the binding between BQ and the enzyme was hydrophobic.	Hydrogen	61-69	sucrase-isomaltase	Homo sapiens	31-48
18835891-1	2009	The exchange rates for the amide hydrogens of beta(2)-microglobulin, the protein responsible for dialysis-related amyloidosis, were measured under native conditions at different temperatures ranging from 301 to 315 K. The pattern of protection factors within different regions of the protein correlates well with the hydrogen-bonding pattern of the deposited structures.	Hydrogen	33-42	beta-2-microglobulin	Homo sapiens	46-67
18835891-1	2009	The exchange rates for the amide hydrogens of beta(2)-microglobulin, the protein responsible for dialysis-related amyloidosis, were measured under native conditions at different temperatures ranging from 301 to 315 K. The pattern of protection factors within different regions of the protein correlates well with the hydrogen-bonding pattern of the deposited structures.	Hydrogen	33-41	beta-2-microglobulin	Homo sapiens	46-67
19200038-3	2009	It was found that the hydrophilic heads of these compounds form four specific conserved hydrogen bonds with the ligand binding pockets of PPARalpha and PPARgamma, which results in fixed head conformations.	Hydrogen	88-96	peroxisome proliferator activated receptor alpha	Homo sapiens	138-147
19200038-5	2009	The oxadiazole-ring-related hydrogen bond interactions well elucidate the structural features governing the different binding behavior of these agonists against PPARalpha and PPARgamma.	Hydrogen	28-36	peroxisome proliferator activated receptor alpha	Homo sapiens	161-170
34490991-6	2021	Also, the binding process of GA to Pin1 was driven through weak van der Walls force, hydrogen bonds and electrostatic forces.	Hydrogen	85-93	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	35-39
34901657-0	2021	Trace Amount of NiP2 Cooperative CoMoP Nanosheets Inducing Efficient Hydrogen Evolution.	Hydrogen	69-77	BCL2 interacting protein 2	Homo sapiens	16-20
34901657-4	2021	Studies have found that although the dosage of NiP2 is very low, its appearance has been efficient to improve the hydrogen evolution reaction (HER) performance of CoMoP, which may be induced by the synergistic effect of the two different components NiP2 and CoMoP.	Hydrogen	114-122	BCL2 interacting protein 2	Homo sapiens	47-51
34901657-4	2021	Studies have found that although the dosage of NiP2 is very low, its appearance has been efficient to improve the hydrogen evolution reaction (HER) performance of CoMoP, which may be induced by the synergistic effect of the two different components NiP2 and CoMoP.	Hydrogen	114-122	BCL2 interacting protein 2	Homo sapiens	249-253
19049272-6	2008	For hydrogen feeds with 0.2% CO and 0.5% O(2) the Rh@Pt NP catalyst has the best activity with complete CO oxidation at 70 degrees C and very high PROX selectivity at 40 degrees C with 50% CO conversion.	Hydrogen	4-12	pyruvate dehydrogenase complex component X	Homo sapiens	147-151
27741492-1	2017	Rotationally state selective excitation of H2(v=1, J=1 or 3) was achieved by stimulated Raman pumping.	Hydrogen	43-45	immunoglobulin kappa joining 1	Homo sapiens	51-59
34677563-1	2021	High-quality CoP nanorings (CoP NRs) are easily achieved using a phosphorating treatment of CoOOH nanorings, and reveal high activity towards the hydrogen evolution reaction and the nitrate electrocatalytic reduction reaction due to substantial coordinately unsaturated active sites, a high surface area, and available mass transfer pathways.	Hydrogen	146-154	caspase recruitment domain family member 16	Homo sapiens	13-16
27897348-7	2017	This work 1) elucidates the crucial role of Ser111 in enzymatic catalysis and thermodynamic stability by active site hydrogen bond network; 2) defines a dynamic model for apo BLVRB extending beyond the crystal structure of the binary BLVRB/NADP+ complex; 3) provides a structural basis for the "encounter" and "equilibrium" states of the binary complex, which are regulated by NAD(P)H.	Hydrogen	117-125	biliverdin reductase B	Homo sapiens	175-180
34672303-2	2021	For this purpose, we evaluated the glass forming ability (GFA), crystallization propensity, molecular mobility and hydrogen bonding structure of a chiral conglomerate forming system, N-acetyl-alpha-methylbenzylamine (Nac-MBA), at various enantiomeric excesses (ees) using experimental and computational techniques.	Hydrogen	115-123	synuclein alpha	Homo sapiens	217-220
34387807-4	2021	Sensing process of F- by PDJ was demonstrated by 1H NMR titration and DFT calculation studies that suggested hydrogen bond interactions followed by deprotonation.	Hydrogen	49-51	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	25-28
18835904-7	2008	For myoglobin, the resilience of the iron environment is larger than the average resilience previously determined for hydrogen sites using neutron scattering.	Hydrogen	118-126	myoglobin	Homo sapiens	4-13
28001341-1	2017	In this work, graphitic C3 N4 decorated with a CoP co-catalyst (g-C3 N4 /CoP) is reported for photocatalytic H2 evolution reaction based on two-step hydrothermal and phosphidation method.	Hydrogen	109-111	caspase recruitment domain family member 16	Homo sapiens	47-50
34387807-4	2021	Sensing process of F- by PDJ was demonstrated by 1H NMR titration and DFT calculation studies that suggested hydrogen bond interactions followed by deprotonation.	Hydrogen	109-117	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	25-28
28001341-1	2017	In this work, graphitic C3 N4 decorated with a CoP co-catalyst (g-C3 N4 /CoP) is reported for photocatalytic H2 evolution reaction based on two-step hydrothermal and phosphidation method.	Hydrogen	109-111	caspase recruitment domain family member 16	Homo sapiens	73-76
34770993-6	2021	Together, GAS are new Hsp90 inhibitors by binding to Hsp90 (hydrogen bond and hydrophobic interaction).	Hydrogen	60-68	heat shock protein 90 alpha family class A member 1	Homo sapiens	22-27
18977146-0	2008	The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase.	Hydrogen	24-32	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	150-153
28001341-6	2017	In addition, g-C3 N4 /CoP-3.4 % is an efficient photocatalyst for H2 evolution under irradiation with natural solar light.	Hydrogen	66-68	caspase recruitment domain family member 16	Homo sapiens	22-25
34770993-6	2021	Together, GAS are new Hsp90 inhibitors by binding to Hsp90 (hydrogen bond and hydrophobic interaction).	Hydrogen	60-68	heat shock protein 90 alpha family class A member 1	Homo sapiens	53-58
26991019-12	2017	The anti-apoptotic property of H2 S may be involved, at least in part, in inhibiting JNK signaling.	Hydrogen	31-33	mitogen-activated protein kinase 8	Rattus norvegicus	85-88
34644772-7	2021	RESULTS: The results show that hydrogen-rich saline treatment markedly increased the survival rate and neurological score, increased neuron survival, downregulated the autophagy protein expression of Beclin-1 and LC3, and endoplasmic reticulum (ER) stress.	Hydrogen	31-39	beclin 1, autophagy related	Mus musculus	200-208
34644772-7	2021	RESULTS: The results show that hydrogen-rich saline treatment markedly increased the survival rate and neurological score, increased neuron survival, downregulated the autophagy protein expression of Beclin-1 and LC3, and endoplasmic reticulum (ER) stress.	Hydrogen	31-39	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	213-216
34651133-0	2021	Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults.	Hydrogen	34-42	gastrin	Homo sapiens	43-46
19053674-2	2008	Observed pressure -induced variations in CD2 and N-D stretching modes indicate significant changes in the hydrogen-bonding interactions.	Hydrogen	106-114	CD2 molecule	Homo sapiens	41-44
27888755-4	2017	METHODS AND PATIENTS: Retrospectively, we analyzed the hs-TnT results of 1573 patients admitted to a level A university hospital emergency department.	Hydrogen	55-57	troponin T1, slow skeletal type	Homo sapiens	58-61
19065219-0	2008	Low propagation loss SiN optical waveguide prepared by optimal low-hydrogen module.	Hydrogen	67-75	embryonal Fyn-associated substrate	Homo sapiens	21-24
34651133-2	2021	Inhaled hydrogen gas diminishes ischemia-reperfusion injury in models of shock, stroke, and cardiac arrest.	Hydrogen	8-16	gastrin	Homo sapiens	17-20
34651133-3	2021	The purpose of this study was to investigate the safety of inhaled hydrogen gas at doses required for a clinical efficacy study.	Hydrogen	67-75	gastrin	Homo sapiens	76-79
34651133-14	2021	Although these data suggest that inhaled hydrogen gas may be well tolerated, future studies need to be powered to further evaluate safety.	Hydrogen	41-49	gastrin	Homo sapiens	50-53
28123000-6	2017	Treatment of mice with an EGFR-inhibitor (EGFRi), Canertinib, 1h post-APAP resulted in robust inhibition of EGFR-activation and a striking reduction in APAP-induced liver injury.	Hydrogen	62-64	epidermal growth factor receptor	Mus musculus	26-30
34676244-7	2021	Prognostic analyses elucidated the essential correlations between MT1A/1B/1H/1X/2A/4 attenuation and poor overall survival, between MT1B/1H/4 downregulation and worse relapse-free survival, and between MT1A/1B/1E/1H/1M/2A/4 downregulation and diminished progression-free survival in HCC.	Hydrogen	137-139	metallothionein 1B	Homo sapiens	132-136
34329992-6	2021	Further, molecular modeling simulations validated the potential of 22 and 23 to have high affinity binding towards Arg22 and Phe31 residues via pi-pi interaction and hydrogen bonding within DHFR binding pocket.	Hydrogen	166-174	dihydrofolate reductase	Homo sapiens	190-194
19045407-0	2008	Experimental evidence of O-H-S hydrogen bonding in supersonic jet.	Hydrogen	31-39	Rh associated glycoprotein	Homo sapiens	25-30
19045407-1	2008	Experimental evidence is presented for the O-H-S hydrogen bonding in the complexes of simple model compounds of methionine (dimethyl sulphide) and tyrosine (phenol, p-cresol, and 2-naphthol).	Hydrogen	49-57	Rh associated glycoprotein	Homo sapiens	43-48
30970702-1	2017	We employ H2/Ar low-damage plasma treatment (H2/Ar-LDPT) to reduce graphene oxide (GO) coating on a polymer substrate-polyethylene terephthalate (PET)-with the assistance of atomic hydrogen (Halpha) at low temperature of 70  C. Four-point probing and ultraviolet-visible (UV-Vis) spectroscopy demonstrate that the conductivity and transmittance can be controlled by varying the H2/Ar flow rate, treatment time, and radio-frequency (RF) power.	Hydrogen	181-189	H2A clustered histone 19	Homo sapiens	10-15
34524269-9	2021	In addition, serum levels of endotoxin, syndecan-1, malondialdehyde, and tumor necrosis factor-alpha decreased, whereas superoxide dismutase levels increased, indicating that inhalation of 2% hydrogen attenuated the damage to the vascular endothelial glycocalyx through its antioxidative and anti-inflammatory effects.	Hydrogen	192-200	syndecan 1	Rattus norvegicus	40-50
34631360-7	2021	Furthermore, the lead molecule can also form hydrogen and salt bridge interactions with binding site residues Asp1621 and Arg1465 residues, respectively of the active pockets of notch 3 protein.	Hydrogen	45-53	notch receptor 3	Homo sapiens	178-185
19045407-6	2008	The atoms-in-molecules and natural bond orbital calculations confirm the O-H-S hydrogen bonding interaction.	Hydrogen	79-87	Rh associated glycoprotein	Homo sapiens	73-78
30970702-1	2017	We employ H2/Ar low-damage plasma treatment (H2/Ar-LDPT) to reduce graphene oxide (GO) coating on a polymer substrate-polyethylene terephthalate (PET)-with the assistance of atomic hydrogen (Halpha) at low temperature of 70  C. Four-point probing and ultraviolet-visible (UV-Vis) spectroscopy demonstrate that the conductivity and transmittance can be controlled by varying the H2/Ar flow rate, treatment time, and radio-frequency (RF) power.	Hydrogen	181-189	H2A clustered histone 19	Homo sapiens	45-50
19045407-7	2008	The significant finding of this study is that the magnitudes of redshifts in the O-H stretch in the O-H-S hydrogen bonded complexes reported here are comparable to those reported for the O-H-O hydrogen bonded complexes where H(2)O acts as the H-bond acceptor, which suggests that the OH-S interaction is perhaps as strong as the OH-O interaction.	Hydrogen	106-114	Rh associated glycoprotein	Homo sapiens	100-105
30970702-1	2017	We employ H2/Ar low-damage plasma treatment (H2/Ar-LDPT) to reduce graphene oxide (GO) coating on a polymer substrate-polyethylene terephthalate (PET)-with the assistance of atomic hydrogen (Halpha) at low temperature of 70  C. Four-point probing and ultraviolet-visible (UV-Vis) spectroscopy demonstrate that the conductivity and transmittance can be controlled by varying the H2/Ar flow rate, treatment time, and radio-frequency (RF) power.	Hydrogen	181-189	H2A clustered histone 19	Homo sapiens	45-50
19045407-7	2008	The significant finding of this study is that the magnitudes of redshifts in the O-H stretch in the O-H-S hydrogen bonded complexes reported here are comparable to those reported for the O-H-O hydrogen bonded complexes where H(2)O acts as the H-bond acceptor, which suggests that the OH-S interaction is perhaps as strong as the OH-O interaction.	Hydrogen	193-201	Rh associated glycoprotein	Homo sapiens	100-105
28008444-0	2017	A robust and efficient catalyst of CdxZn1-xSe motivated by CoP for photocatalytic hydrogen evolution under sunlight irradiation.	Hydrogen	82-90	caspase recruitment domain family member 16	Homo sapiens	59-62
19045407-8	2008	To the best of our knowledge, this is the first such report on the O-H-S hydrogen bonded complexes.	Hydrogen	73-81	Rh associated glycoprotein	Homo sapiens	67-72
34543014-7	2021	Moreover, YPVEPF and YFYPEL could bind with the Ser-205 and Phe-77 residues of GABAAR via hydrogen bonds and lipid contacts.	Hydrogen	90-98	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	79-85
34473496-13	2021	The long-term simulation result shows that hBD-3 can bind with the heads of negatively charged POPS and PIP2 lipids and form hydrogen bonds.	Hydrogen	125-133	defensin beta 103B	Homo sapiens	43-48
28008444-1	2017	CdxZn1-xSe/CoP composites have been well studied as effervescent photocatalysts for H2 evolution.	Hydrogen	84-86	caspase recruitment domain family member 16	Homo sapiens	11-14
28008444-4	2017	Advances in CdxZn1-xSe/CoP for photocatalytic H2 evolution provide a new strategy for future splitting of seawater.	Hydrogen	46-48	caspase recruitment domain family member 16	Homo sapiens	23-26
18663492-7	2008	Further CATALYST-based 3D space modeling demonstrates that the presence of the aromatic ring (ring A), hydrophobic zone (ring B), and hydrogen bond acceptor at C17 in ring D, along with steric influence due to conformational rigidity of the compound, impart estrogenic contraceptive activity, but the presence of a second acceptor in ring A, and the critical distances between these features, selectively differentiate the anti-fertility potency from the estrogenic activity.	Hydrogen	134-142	cytokine like 1	Homo sapiens	160-163
27700100-6	2017	Hydrogen-deuterium exchange and a cell-free MHC class II antigen processing system revealed that proteolysis of PAD4 by GrB induced discrete structural changes in PAD4 that promoted enhanced presentation of several immunogenic peptides capable of stimulating PAD4-specific CD4+ T cells from patients with RA.	Hydrogen	0-8	peptidyl arginine deiminase 4	Homo sapiens	163-167
27783482-0	2017	An Asymmetric Runaway Domain Swap Antithrombin Dimer as a Key Intermediate for Polymerization Revealed by Hydrogen/Deuterium-Exchange Mass Spectrometry.	Hydrogen	106-114	serpin family C member 1	Homo sapiens	34-46
18948593-3	2008	Here, we report the architecture of the complex between the yeast Hsp110, Sse1, and its cognate Hsp70 partner, Ssa1, as revealed by hydrogen-deuterium exchange analysis and site-specific cross-linking.	Hydrogen	132-140	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	111-115
18948593-6	2008	To address the mechanism of catalyzed nucleotide exchange, we have compared the hydrogen exchange characteristics of the Ssa1 NBD in complex with either Sse1 or the yeast homologs of the NEFs HspBP1 and Bag-1.	Hydrogen	80-88	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	121-125
34514978-14	2022	The molecular docking results demonstrated that compounds 2f and 3a were firmly bound in a complex with EGFR via the formation of a hydrogen bond.	Hydrogen	132-140	epidermal growth factor receptor	Mus musculus	104-108
34232231-3	2021	This was mainly due to the spontaneous formation of Q3GA-alpha-glucosidase driven by hydrogen bonding and van der Waals forces, which could change the microenvironments and conformation of alpha-glucosidase.	Hydrogen	85-93	sucrase-isomaltase	Homo sapiens	189-206
27783482-6	2017	Here, we show how hydrogen/deuterium-exchange mass spectrometry (HDX-MS) provides detailed insight into the structural dynamics of each subunit in a polymerization-competent antithrombin dimer.	Hydrogen	18-26	serpin family C member 1	Homo sapiens	174-186
27863383-6	2016	We also found that phosphorylated AKT and STAT3 but not the proteins expression reached peak after 1h and 6h treatment of leptin, respectively.	Hydrogen	99-101	leptin	Homo sapiens	122-128
34557149-1	2021	The onco-metabolite 2-hydroxyglutarate (2HG), a biomarker of IDH-mutant gliomas, can be detected with 1H MR spectroscopy (1H-MRS).	Hydrogen	102-104	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	61-64
34557149-1	2021	The onco-metabolite 2-hydroxyglutarate (2HG), a biomarker of IDH-mutant gliomas, can be detected with 1H MR spectroscopy (1H-MRS).	Hydrogen	122-124	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	61-64
18759395-7	2008	Spectroscopic study of the photolyses solutions suggests that H2 formation proceeds via Co(I) and protonation to form Co(III) hydride species.	Hydrogen	62-64	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	88-93
18712732-0	2008	Cooperativity between the dihydrogen bond and the NHC hydrogen bond in LiH-(HCN)n Complexes.	Hydrogen	26-36	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	76-79
34128259-12	2021	Molecular docking revealed that most of these compounds fit well into the ATP-binding site of SphK1 and form hydrogen bond interactions with catalytically important residues.	Hydrogen	109-117	sphingosine kinase 1	Homo sapiens	94-99
34419448-4	2021	identify a critical interdomain hydrogen bond within RagA and RagC that stabilizes their GDP-bound states.	Hydrogen	32-40	Ras related GTP binding A	Homo sapiens	53-57
27973864-0	2016	Tracking Co(I) Intermediate in Operando in Photocatalytic Hydrogen Evolution by X-ray Transient Absorption Spectroscopy and DFT Calculation.	Hydrogen	58-66	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	9-14
34419448-4	2021	identify a critical interdomain hydrogen bond within RagA and RagC that stabilizes their GDP-bound states.	Hydrogen	32-40	Ras related GTP binding C	Homo sapiens	62-66
18712732-0	2008	Cooperativity between the dihydrogen bond and the NHC hydrogen bond in LiH-(HCN)n Complexes.	Hydrogen	28-36	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	76-79
27973864-1	2016	X-ray transient absorption spectroscopy (XTA) and optical transient spectroscopy (OTA) were used to probe the Co(I) intermediate generated in situ from an aqueous photocatalytic hydrogen evolution system, with [RuII(bpy)3]Cl2 6H2O as the photosensitizer, ascorbic acid/ascorbate as the electron donor, and the Co-polypyridyl complex ([CoII(DPA-Bpy)Cl]Cl) as the precatalyst.	Hydrogen	178-186	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	110-115
34296449-3	2021	The FAGDDAPR and LAPPRGSL were identified by LC-MS/MS method, and the molecular models of DPP-IV and the two peptides were further constructed by AutoDock Vina software, the results revealed that the inhibition activity of FAGDDAPR and LAPPRGSL was mainly attributed to the formation of strong hydrophobic interactions and hydrogen bonds with amino acids of DPP-IV.	Hydrogen	323-331	dipeptidyl peptidase 4	Homo sapiens	90-96
34296449-3	2021	The FAGDDAPR and LAPPRGSL were identified by LC-MS/MS method, and the molecular models of DPP-IV and the two peptides were further constructed by AutoDock Vina software, the results revealed that the inhibition activity of FAGDDAPR and LAPPRGSL was mainly attributed to the formation of strong hydrophobic interactions and hydrogen bonds with amino acids of DPP-IV.	Hydrogen	323-331	dipeptidyl peptidase 4	Homo sapiens	358-364
18712732-1	2008	The cooperativity between the dihydrogen bond and the NHC hydrogen bond in LiH-(HCN)(n) (n=2 and 3) complexes is investigated at the MP2 level of theory.	Hydrogen	30-40	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	80-83
27331911-1	2016	In a recent investigation carried out on a panel of trimethoxybenzanilides, we showed that the formation of an intramolecular hydrogen bond is a key element for tuning P-gp inhibitory activity.	Hydrogen	126-134	phosphoglycolate phosphatase	Homo sapiens	168-172
18662036-6	2008	In one form, two successive C12 hydrogen bonds were obtained at the N-terminus, while a novel C17 hydrogen-bonded gamma alpha gamma turn was observed at the C-terminus.	Hydrogen	98-106	cytokine like 1	Homo sapiens	94-97
34318845-5	2021	Notably, the Ni species (Nin+) promoted the decomposition of water and produced hydrogen intermediates, which were then immediately adsorbed on the surface of Pt and recombined into molecular hydrogen.	Hydrogen	80-88	ninein	Homo sapiens	25-28
34318845-5	2021	Notably, the Ni species (Nin+) promoted the decomposition of water and produced hydrogen intermediates, which were then immediately adsorbed on the surface of Pt and recombined into molecular hydrogen.	Hydrogen	192-200	ninein	Homo sapiens	25-28
27694444-0	2016	Structural Dynamics of the Vimentin Coiled-coil Contact Regions Involved in Filament Assembly as Revealed by Hydrogen-Deuterium Exchange.	Hydrogen	109-117	vimentin	Homo sapiens	27-35
27767019-4	2016	These monolithic CoP NAs/CC show a maximum hydrogen generation rate of [Formula: see text] and are robust with superior durability and reusability.	Hydrogen	43-51	caspase recruitment domain family member 16	Homo sapiens	17-20
27819104-4	2016	Calculations at the MP2/RI-CC2 and DFT-omegaB97X-D levels indicate that hydrogen-bonded (HB) and pi-stacked isomers are almost isoenergetic in the ground state while in the excited state only the pi-stacked isomer exists.	Hydrogen	72-80	tryptase pseudogene 1	Homo sapiens	20-30
27808289-0	2016	Importance of the structural integrity of a carbon conjugated mediator for photocatalytic hydrogen generation from water over a CdS-carbon nanotube-MoS2 composite.	Hydrogen	90-98	CDP-diacylglycerol synthase 1	Homo sapiens	128-131
27808289-1	2016	Incorporation of CdS quantum dots is shown to significantly promote photocatalytic hydrogen production from water over single-layer MoS2 in a remote manner via their dispersions on a carbon nanotube as a nanocomposite: the hydrogen evolution rate is found to be critically dependent on the content and structural integrity of the carbon nanotube such that the double-walled carbon nanotube shows superior H2 production to a single-walled carbon nanotube because the inner carbon tubules survive from the structural damage during functionalization.	Hydrogen	83-91	CDP-diacylglycerol synthase 1	Homo sapiens	17-20
27808289-1	2016	Incorporation of CdS quantum dots is shown to significantly promote photocatalytic hydrogen production from water over single-layer MoS2 in a remote manner via their dispersions on a carbon nanotube as a nanocomposite: the hydrogen evolution rate is found to be critically dependent on the content and structural integrity of the carbon nanotube such that the double-walled carbon nanotube shows superior H2 production to a single-walled carbon nanotube because the inner carbon tubules survive from the structural damage during functionalization.	Hydrogen	223-231	CDP-diacylglycerol synthase 1	Homo sapiens	17-20
27808289-1	2016	Incorporation of CdS quantum dots is shown to significantly promote photocatalytic hydrogen production from water over single-layer MoS2 in a remote manner via their dispersions on a carbon nanotube as a nanocomposite: the hydrogen evolution rate is found to be critically dependent on the content and structural integrity of the carbon nanotube such that the double-walled carbon nanotube shows superior H2 production to a single-walled carbon nanotube because the inner carbon tubules survive from the structural damage during functionalization.	Hydrogen	405-407	CDP-diacylglycerol synthase 1	Homo sapiens	17-20
27523033-5	2016	Additionally, cells treated with 50ng of GL showed an increase in GABAAR (23%) after 1h followed by an increase in nNOS (55, 46 and 55%) at 8, 12 and 24h time points, respectively.	Hydrogen	85-87	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	66-72
27577093-6	2016	We determined the structure of zebrafish Casp3a to 2.28A resolution by X-ray crystallography, and when combined with molecular dynamics simulations, the results suggest that a limited number of amino acid substitutions near the active site result in plasticity of the S4 sub-site by increasing flexibility of one active site loop and by affecting hydrogen-bonding with substrate.	Hydrogen	347-355	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	41-47
27639427-7	2016	In all brain regions tested, bax mRNA decreased 1h post exposure followed by an increase 24h later, with only minor increase in bcl2 mRNA.	Hydrogen	48-50	BCL2 associated X, apoptosis regulator	Rattus norvegicus	29-32
27711762-2	2016	Noteworthily, the marked differences in the structure and photochromic performance of 1 and 2 are largely ascribed to the different aggregating behavior of electron-deficient MCMP+ counterions (C-HO hydrogen bonded trimer in 1 and pi-pi/C-Hpi chain in 2).	Hydrogen	199-207	ADAM metallopeptidase domain 9	Homo sapiens	175-179
27667798-4	2016	The resultant N, P, and F tri-doped graphene exhibited excellent electrocatalytic activities for the oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER).	Hydrogen	171-179	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	26-29
27667798-6	2016	The integrated unit, fabricated from the newly developed N, P, and F tri-doped graphene multifunctional metal-free catalyst, can operate in ambient air with a high gas production rate of 0.496 and 0.254 muL s-1 for hydrogen and oxygen gas, respectively, showing great potential for practical applications.	Hydrogen	215-223	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	69-72
27569420-4	2016	Furthermore, the catalytic olefin hydrogenation activity of the Co(I) species was studied by using multinuclear and parahydrogen (p-H2) induced polarization (PHIP) transfer NMR studies to elucidate catalytically relevant intermediates, as well as to establish the role of the Co(I)-(H2) in the Co(I)/Co(III) redox cycle.	Hydrogen	132-134	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	64-69
27402847-8	2016	The data generated in this study are combined to input constraints for a molecular model of the Hsp90/Tom70 interaction, which has been validated by small angle x-ray scattering, hydrogen/deuterium exchange, and mass spectrometry.	Hydrogen	179-187	heat shock protein 90 alpha family class B member 1	Homo sapiens	96-101
27529565-0	2016	Unraveling a Single-Step Simultaneous Two-Electron Transfer Process from Semiconductor to Molecular Catalyst in a CoPy/CdS Hybrid System for Photocatalytic H2 Evolution under Strong Alkaline Conditions.	Hydrogen	156-158	CDP-diacylglycerol synthase 1	Homo sapiens	119-122
27529565-2	2016	Thermodynamic and kinetic studies revealed that photocatalytic H2 evolution under high pH conditions (pH 13.5) can only account for the thermodynamically more favorable single-step simultaneous two-electron transfer from photoirradiated CdS to Co(III)Py to produce unavoidable intermediate Co(I)Py, rather than a two-step successive one-electron transfer process.	Hydrogen	63-65	CDP-diacylglycerol synthase 1	Homo sapiens	237-240
27365393-8	2016	Comparative molecular dynamics indicated that Ser(36) upon phosphorylation will pull the first luminal loop of LTC4S toward the neighboring subunit of the functional homotrimer, thereby forming hydrogen bonds with Arg(104) in the adjacent subunit.	Hydrogen	194-202	leukotriene C4 synthase	Homo sapiens	111-116
27558955-0	2016	Molecular hydrogen suppresses activated Wnt/beta-catenin signaling.	Hydrogen	10-18	catenin beta 1	Rattus norvegicus	44-56
27558955-4	2016	We found that H2 suppresses activated Wnt/beta-catenin signaling by promoting phosphorylation and degradation omicronf beta-catenin.	Hydrogen	14-16	catenin beta 1	Rattus norvegicus	42-54
27558955-4	2016	We found that H2 suppresses activated Wnt/beta-catenin signaling by promoting phosphorylation and degradation omicronf beta-catenin.	Hydrogen	14-16	catenin beta 1	Rattus norvegicus	119-131
27558955-5	2016	Either complete inhibition of GSK3 or mutations at CK1- and GSK3-phosphorylation sites of beta-catenin abolished the suppressive effect of H2.	Hydrogen	139-141	catenin beta 1	Rattus norvegicus	90-102
27558955-7	2016	Knock-down of adenomatous polyposis coli (APC) or Axin1, which form the beta-catenin degradation complex, minimized the suppressive effect of H2 on beta-catenin accumulation.	Hydrogen	142-144	catenin beta 1	Rattus norvegicus	72-84
27558955-7	2016	Knock-down of adenomatous polyposis coli (APC) or Axin1, which form the beta-catenin degradation complex, minimized the suppressive effect of H2 on beta-catenin accumulation.	Hydrogen	142-144	catenin beta 1	Rattus norvegicus	148-160
27558955-8	2016	Accordingly, the effect of H2 requires CK1/GSK3-phosphorylation sites of beta-catenin, as well as the beta-catenin degradation complex comprised of CK1, GSK3, APC, and Axin1.	Hydrogen	27-29	catenin beta 1	Rattus norvegicus	73-85
27558955-8	2016	Accordingly, the effect of H2 requires CK1/GSK3-phosphorylation sites of beta-catenin, as well as the beta-catenin degradation complex comprised of CK1, GSK3, APC, and Axin1.	Hydrogen	27-29	catenin beta 1	Rattus norvegicus	102-114
27558955-9	2016	We additionally found that H2 reduces the activation of Wnt/beta-catenin signaling in human osteoarthritis chondrocytes.	Hydrogen	27-29	catenin beta 1	Homo sapiens	60-72
27558955-11	2016	We first demonstrate that H2 suppresses abnormally activated Wnt/beta-catenin signaling, which accounts for the protective roles of H2 in a fraction of diseases.	Hydrogen	26-28	catenin beta 1	Rattus norvegicus	65-77
27558955-11	2016	We first demonstrate that H2 suppresses abnormally activated Wnt/beta-catenin signaling, which accounts for the protective roles of H2 in a fraction of diseases.	Hydrogen	132-134	catenin beta 1	Rattus norvegicus	65-77
27476445-6	2016	Spectroscopic studies of the photocatalytic reaction revealed the reduction of the Co(ii) complex to Co(i) species, which are probably active intermediates for hydrogen evolution.	Hydrogen	160-168	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	101-106
29342347-2	2016	In this study, a series of carboxymethyl chitosan/daunorubicin (CMCS/DNR) conjugates with macromolecular carriers of different molecular weights (MWs) were prepared and structurally characterized by Fourier transform infrared spectroscopy (FT-IR) and 1H-NMR spectroscopy.	Hydrogen	251-253	G protein signaling modulator 2	Homo sapiens	64-68
34432157-4	2021	A ligand-based pharmacophore model was conducted on a set of 43 diverse alpha-syn ligands, and the results suggested that two hydrogen-bond acceptors, one hydrophobic group, and two aromatic rings were significant to the inhibition of alpha-syn aggregation.	Hydrogen	126-134	synuclein alpha	Homo sapiens	72-81
34432157-4	2021	A ligand-based pharmacophore model was conducted on a set of 43 diverse alpha-syn ligands, and the results suggested that two hydrogen-bond acceptors, one hydrophobic group, and two aromatic rings were significant to the inhibition of alpha-syn aggregation.	Hydrogen	126-134	synuclein alpha	Homo sapiens	235-244
34432157-10	2021	Based on the best pharmacophore modeling, novel indolinone derivatives were designed and synthesized, and the inhibitory activities for alpha-synuclein aggregation were evaluated by thioflavin-T assay in vitro, which preliminary indicated that five pharmacophore sites (two hydrogen bond acceptors (A), a hydrophobic group (H), and two aromatic rings (R)) in compounds contribute to the inhibitory activities.	Hydrogen	274-282	synuclein alpha	Homo sapiens	136-151
18366018-7	2008	The hydrogen bonding ability and nucleophilic nature of N1 appeared to be important for governing the interaction with PDE7.	Hydrogen	4-12	phosphodiesterase 7A	Homo sapiens	119-123
19049047-2	2008	NMe2)2] (1) as a yellow crystalline solid, which was characterized by elemental analysis, UV-vis, mass and NMR (1H, 13C, 125Te, 199Hg) spectroscopy.	Hydrogen	112-114	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	0-4
34328729-2	2021	Specifically, the hydrogen generation rate over single site Ru1/CeO2 catalyst is up to 9360 mol H2 per mol Ru per hour (579 mLH2 gRu-1 s-1) with 99.5% CO2 selectivity.	Hydrogen	18-26	LIM homeobox protein 2	Mus musculus	124-128
27412860-8	2016	Comparative molecular dynamics simulations and quantum mechanics/molecular mechanics calculations indicated that, for the 15-lipoxygenating rabbit ALOX15, the energy barrier for C13-hydrogen abstraction (15-lipoxygenation) was 17 kJ/mol lower than for arachidonic acid 12-lipoxygenation.	Hydrogen	182-190	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	147-153
34445210-13	2021	Fumarate and malate were increased after IR 1h in CA2-4,DG and this was reversed by betaIIV5-3 what correlated with GLS1 activity increases and earlier showed elevation of neuronal death (Krupska et al., 2017).	Hydrogen	44-46	glutaminase	Homo sapiens	116-120
34102474-2	2021	Our previous study on the crystal structure of the state 1 conformation of H-Ras in complex with guanosine 5"-(beta, gamma-imido)triphosphate (GppNHp) indicated that state 1 is stabilized by intramolecular hydrogen-bonding interactions formed by Gln61.	Hydrogen	206-214	HRas proto-oncogene, GTPase	Homo sapiens	75-80
18474681-3	2008	We have purified the N3- and N1-glucuronides of dexmedetomidine, termed DG1 and DG2, respectively, according to their elution order in liquid chromatography and determined their structure by 1H nuclear magnetic resonance (NMR).	Hydrogen	191-193	desmocollin 2	Homo sapiens	80-83
18583986-3	2008	One loop moves to form a solvent cover for the active site of the enzyme and reaches towards the target residue (diphthamide) in eEF2 forming an important hydrogen bond.	Hydrogen	155-163	eukaryotic translation elongation factor 2	Homo sapiens	129-133
27237623-4	2016	As a result, the MoS2/CdS nanosheets-on-nanorod exhibits a state-of-the-art H2 evolution rate of 49.80 mmol g(-1) h(-1) and an apparent quantum yield of 41.37% at 420 nm, which is the advanced performance among all MoS2/CdS composites and CdS/noble metal photocatalysts.	Hydrogen	76-78	CDP-diacylglycerol synthase 1	Homo sapiens	22-25
34353273-12	2022	Molecular docking demonstrated that BEA formed hydrogen bond with His425 and pi-pi staking with Tyr429 in ACAT1.	Hydrogen	47-55	acetyl-CoA acetyltransferase 1	Homo sapiens	106-111
27375351-12	2016	Further, crystal structural modeling suggested generation of two abnormal hydrogen bonds by the missense mutation p.G2186E (c.6557G&gt;A) and elongation of its neighboring beta-sheet induced by p.G3083D (c.9248G&gt;A), which could alter the tertiary structure of the eys protein and thus interrupt its physicochemical properties.	Hydrogen	74-82	eyes shut homolog	Homo sapiens	267-270
34302811-4	2021	Hydrogen deuterium exchange mass spectrometry revealed that the flexibility of the interdomain region was significantly suppressed upon strong binding to TEM1, but was not significantly changed upon weak binding to SHV1 or PC1.	Hydrogen	0-8	CD248 molecule	Homo sapiens	154-158
34302811-4	2021	Hydrogen deuterium exchange mass spectrometry revealed that the flexibility of the interdomain region was significantly suppressed upon strong binding to TEM1, but was not significantly changed upon weak binding to SHV1 or PC1.	Hydrogen	0-8	proprotein convertase subtilisin/kexin type 1	Homo sapiens	223-226
18508966-0	2008	Characterization of the sodium/hydrogen exchanger NHA2.	Hydrogen	31-39	solute carrier family 9 member B2	Homo sapiens	50-54
27192134-8	2016	Similarly, the H-bond-like interactions involving the H(2) site are found to be particularly enhanced in comparison with the ones at H(4-5) in the case of asymmetric and/or more basic anions (C4mimOAc, C4mimCl, C4mimTfO, and C4mimTFSA), in accordance with recent spectroscopic and theoretical findings.	Hydrogen	54-58	complement C4A (Rodgers blood group)	Homo sapiens	225-234
18508966-10	2008	Regarding function, human NHA2 reversed the sodium/hydrogen exchanger-null phenotype when expressed in sodium/hydrogen exchanger-deficient yeast and restored the ability to defend high salinity in the presence of acidic extracellular pH.	Hydrogen	51-59	solute carrier family 9 member B2	Homo sapiens	26-30
18508966-10	2008	Regarding function, human NHA2 reversed the sodium/hydrogen exchanger-null phenotype when expressed in sodium/hydrogen exchanger-deficient yeast and restored the ability to defend high salinity in the presence of acidic extracellular pH.	Hydrogen	110-118	solute carrier family 9 member B2	Homo sapiens	26-30
26855359-2	2016	Alkaline (pH=9.3) bioelectrochemical hydrogen production presented better performance (+117%) compared to conventional neutral conditions (2.6 vs 1.2 litres of hydrogen gas per litre of reactor per day, LH2 L(-1)REACTOR d(-1)).	Hydrogen	37-45	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	203-206
18570440-7	2008	Lastly, a search of the Protein Data Bank (PDB) produces several candidate hydrogen-bonded aspartic/glutamic acid-cysteine interactions, which we propose are particularly common in the DJ-1 superfamily.	Hydrogen	75-83	Parkinsonism associated deglycase	Homo sapiens	185-189
26850220-4	2016	Designated as an edge-to-face (EtF or FtE) interaction, large ring current shifts are produced at the edge aryl ring hydrogens and, in most cases, large exciton couplets appear in the far UV circular dichroic (CD) spectrum.	Hydrogen	117-126	TEA domain transcription factor 2	Homo sapiens	31-34
18239913-2	2008	Using elastic neutron scattering we investigate the temperature dependence of the mean square displacements of non-exchangeable hydrogen atoms of sol-gel encapsulated met-myoglobin.	Hydrogen	128-136	myoglobin	Homo sapiens	171-180
27082784-9	2016	Our studies also revealed differing dynamics of the hydrogen bonds between CBP-R646 and c-Myb-E306 and between CBP-E665 and c-Myb-R294 caused by the CBP KIX mutations.	Hydrogen	52-60	myeloblastosis oncogene	Mus musculus	88-98
18688399-10	2008	The ESR spectra of a range of Rh(II) complexes show coupling to both 14N and 103Rh nuclei in most cases but what appears to be coupling to rhodium and one hydrogen atom, possibly a hydride ligand, for the oxidation product of [Rh(eta-nbd)Tp(Ph)].	Hydrogen	155-163	Rh blood group D antigen	Homo sapiens	30-36
18366203-1	2008	An ab initio computational study of the regulating function of the methyl group in the strength of the CH...O hydrogen bond (HB) with XCC-H (X = H, CH3, F) as a HB donor and HOY (Y = H, CH3, Cl) as a HB acceptor has been carried out at the MP2/aug-cc-pVDZ and MP2/aug-cc-pVTZ levels.	Hydrogen	110-118	tryptase pseudogene 1	Homo sapiens	240-243
18366203-1	2008	An ab initio computational study of the regulating function of the methyl group in the strength of the CH...O hydrogen bond (HB) with XCC-H (X = H, CH3, F) as a HB donor and HOY (Y = H, CH3, Cl) as a HB acceptor has been carried out at the MP2/aug-cc-pVDZ and MP2/aug-cc-pVTZ levels.	Hydrogen	110-118	tryptase pseudogene 1	Homo sapiens	260-263
27082784-9	2016	Our studies also revealed differing dynamics of the hydrogen bonds between CBP-R646 and c-Myb-E306 and between CBP-E665 and c-Myb-R294 caused by the CBP KIX mutations.	Hydrogen	52-60	myeloblastosis oncogene	Mus musculus	88-93
27082784-10	2016	In the wild-type CBP:c-Myb complex, both of the hydrogen bonds stayed relatively stable.	Hydrogen	48-56	myeloblastosis oncogene	Mus musculus	21-26
27082784-11	2016	In contrast, in the mutant CBP:c-Myb complex, hydrogen bonds between R646 and E306 showed an increasing trend followed by a decreasing trend, and hydrogen bonds of the E665:R294 pair exhibited a fast decreasing trend over time during MD simulations.	Hydrogen	46-54	myeloblastosis oncogene	Mus musculus	31-36
18375128-4	2008	For aP2, the ability of the receptor protein to change its hydrogen bond interactions in the beta-strands to accommodate different ligand scaffolds seems to make this receptor difficult for structure based drug design.	Hydrogen	59-67	fatty acid binding protein 4	Homo sapiens	4-7
27082784-11	2016	In contrast, in the mutant CBP:c-Myb complex, hydrogen bonds between R646 and E306 showed an increasing trend followed by a decreasing trend, and hydrogen bonds of the E665:R294 pair exhibited a fast decreasing trend over time during MD simulations.	Hydrogen	146-154	myeloblastosis oncogene	Mus musculus	31-36
27250312-5	2016	MP2 predicts quantitatively correctly the thermal contraction at low temperatures, which is confirmed to originate from the volume-contracting hydrogen-bond bending modes (acoustic phonons).	Hydrogen	143-151	tryptase pseudogene 1	Homo sapiens	0-3
18272370-4	2008	Docking of the stilbenes inside PPARalpha showed the presence of important hydrogen bond interactions for PPARalpha activation.	Hydrogen	75-83	peroxisome proliferator activated receptor alpha	Rattus norvegicus	32-41
18272370-4	2008	Docking of the stilbenes inside PPARalpha showed the presence of important hydrogen bond interactions for PPARalpha activation.	Hydrogen	75-83	peroxisome proliferator activated receptor alpha	Rattus norvegicus	106-115
27198662-6	2016	OPN depletion is associated with reduced tumor growth, decreased angiogenesis, and an increase of tumor-associated metabolites, as revealed by T2-weighted images, diffusion-weighted images, K(trans) maps, and 1H-MRS, respectively.	Hydrogen	209-211	secreted phosphoprotein 1	Homo sapiens	0-3
27087591-6	2016	It is found that depending on the fractions of CH4 , C2 H6 , and CO2 , different sorbents allow for optimal H2 S removal and hydrocarbon recovery.	Hydrogen	108-110	complement C2	Homo sapiens	53-68
18260615-3	2008	Investigation of the SAR reveals that a sterically unhindered hydrogen bond acceptor attached to C-17 is most likely key to the enhanced activity.	Hydrogen	62-70	cytokine like 1	Homo sapiens	97-101
27075974-2	2016	The products are obtained by selective alkoxycarbonylation catalyzed by Pd2(dba)3, 1,4-bis(diphenylphisphino)butane (dppb), and syngas (CO/H2) in chloroform/alcohol.	Hydrogen	139-141	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	72-75
18278905-1	2008	Ab initio quantum mechanical calculations at the MP2 level were used for an extensive study concerning the stability of hydrogen-bonded complexes formed by pyrrole and thiophene, which are the most common building blocks of conducting polymers, and DNA bases.	Hydrogen	120-128	tryptase pseudogene 1	Homo sapiens	49-52
18054351-4	2008	The polysaccharide retains the half-staggered, parallel, 3-fold, right-handed double helix stabilized by interchain hydrogen bonds from O-2H and O-6H in the Galp units.	Hydrogen	116-124	galanin like peptide	Homo sapiens	157-161
27065023-0	2016	Semimetallic MoP2: an active and stable hydrogen evolution electrocatalyst over the whole pH range.	Hydrogen	40-48	endothelial PAS domain protein 1	Homo sapiens	13-17
27065023-3	2016	When used as a binder-free hydrogen evolution cathode, the as-prepared MoP2 NPs/Mo electrode exhibits superior HER catalytic activity at all pH values.	Hydrogen	27-35	endothelial PAS domain protein 1	Homo sapiens	71-75
18377188-15	2008	Muscular (abdominal or thoracic wall) and retroperitoneal BCS were higher in the HS group (10 and 12 in the HS group versus 5 and 2 in the CM group, respectively; p &lt; 0.0001).	Hydrogen	81-83	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	58-61
18377188-24	2008	Bleeding was a late complication in the CM group and frequently in the CNS, while BCS was more frequently associated with muscular or retroperitoneal sites in the HS treated group.	Hydrogen	163-165	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	82-85
27056800-5	2016	For barrier heights of hydrogen transfer reaction energies, the DF-OLCCD method again exhibits a substantially better performance than DF-LCCD, providing a mean absolute error of 0.9 kcal mol(-1), which is 7 times lower than that of DF-LCCD (6.2 kcal mol(-1)), and compared to MP2 (9.6 kcal mol(-1)) there is a more than 10-fold reduction in errors.	Hydrogen	23-31	tryptase pseudogene 1	Homo sapiens	277-280
18830990-3	2008	Notwithstanding, derivatives of alpha-L-Rhamp-(1--&gt;4)-alpha-D-Glcp or alpha-D-Manp-(1--&gt;4)-alpha-D-Galp exclusively abstract the hydrogen from H--C-1" through a seven-membered transition state and, therefore, lead to an interglycosidic spiro ortho ester.	Hydrogen	135-143	galanin like peptide	Homo sapiens	105-109
26932393-5	2016	Subsequent reduction with hydrogen provided a microporous composite containing crystalline germanium and carbon (Ge@C -C-1, germanium content ~20%).	Hydrogen	26-34	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	119-122
17918756-0	2008	Reinforced self-assembly of hexa-peri-hexabenzocoronenes by hydrogen bonds: from microscopic aggregates to macroscopic fluorescent organogels.	Hydrogen	60-68	hexosaminidase subunit alpha	Homo sapiens	28-32
17918756-1	2008	Hexa-peri-hexabenzocoronene derivatives (HBCs) that have hydrogen-bonding functionalities (either amido or ureido groups) adjacent to the aromatic cores have been synthesized to study the effects of intracolumnar hydrogen bonds on the self-assembly behavior of HBCs.	Hydrogen	57-65	hexosaminidase subunit alpha	Homo sapiens	0-4
26590577-0	2016	Sequence-specific 1H, 13C and 15N backbone resonance assignments of the plakin repeat domain of human envoplakin.	Hydrogen	18-20	envoplakin	Homo sapiens	102-112
17913561-0	2008	1H-MRS experiences after bilateral DBS of the STN in Parkinson"s disease.	Hydrogen	0-2	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	46-49
26748655-0	2016	1H, 15N, 13C resonance assignment of human GAP-43.	Hydrogen	0-2	growth associated protein 43	Homo sapiens	43-49
18044969-7	2007	The electrostatic interactions between the positive charges on AdoMet and SET7/9.Lys4-NH3+ decrease the pKa of the latter from 10.9 +/- 0.4 to 8.2 +/- 0.6, and this is not seen in the SET7/9.Lys4-N(Me)H2+.AdoMet species.	Hydrogen	201-203	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	74-80
18044969-9	2007	By QM/MM, the calculated free energy barrier of the methyl transfer reaction in the SET7/9 [Lys4-NH2 + AdoMet --&gt; Lys4-N(Me)H2+ + AdoHcy] complex is DeltaG++ = 19.0 +/- 1.6 kcal/mol.	Hydrogen	98-100	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	84-90
26559687-4	2016	It is known that BPs bind to calcium by chemisorptions to form Ca-BP complexes through (O)P-C-P(O) moiety and hydrogen coordinations, and so they suppress calcium flow by interfering with Ca(2+) channel operations.	Hydrogen	110-118	S100 calcium binding protein G	Rattus norvegicus	63-68
18020379-3	2007	However, for dithiothreitol, the spectrum of the adsorbed species is significantly different from that of the solution species and is attributed to an interruption of intermolecular hydrogen bonding upon adsorption to the CdS.	Hydrogen	182-190	CDP-diacylglycerol synthase 1	Homo sapiens	222-225
26963935-3	2016	On the basis of the crystal characteristics, the modeling of the interactions between ofloxacin and the Fab revealed that TYR31 and HIS99 of the heavy chain and MET20 and GLN79 of the light chain formed a hydrophobic region and that SER52 and ALA97 of the heavy chain and TYR35 of the light chain formed a salt bridge and two hydrogen bonds for specific binding.	Hydrogen	326-334	FA complementation group B	Homo sapiens	104-107
18198586-3	2007	Nd3+ with higher concentration than the bacteriostatic concentration can break the peptide bond and the hydrogen bond so as to break the net structure in the peptideoglycan cell.	Hydrogen	104-112	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	0-3
34325884-7	2021	Inhibition of SGLT2 may also lead to a reduction in the activity of sodium-hydrogen exchangers in the kidney (leading to diuresis) and in the heart (attenuating the development of cardiac hypertrophy and systolic dysfunction).	Hydrogen	75-83	solute carrier family 5 member 2	Homo sapiens	14-19
27023502-0	2016	From Nanorods to Nanowires of CdS Synthesized by a Solvothermal Method: Influence of the Morphology on the Photoactivity for Hydrogen Evolution from Water.	Hydrogen	125-133	CDP-diacylglycerol synthase 1	Homo sapiens	30-33
34171644-4	2021	The transformation from nanowires to nanotubes improves the crystallinity of CoP and fully exposes active sites, producing energetic atomic hydrogen for dehalogenation.	Hydrogen	140-148	caspase recruitment domain family member 16	Homo sapiens	77-80
17939663-2	2007	In the complex formed between morphinone reductase (MR) and the NADH analogue 1,4,5,6-tetrahydro-NADH (NADH4) the nicotinamide moiety is restrained close to the FMN isoalloxazine ring by hydrogen bonds from Asn-189 and His-186 as determined from the X-ray crystal structure.	Hydrogen	187-195	formin 1	Homo sapiens	161-164
17986339-4	2007	RESULTS: We found that the smallest ligand stabilizing an open conformer of the RTA active site pocket was an amide group, bound weakly by only a few hydrogen bonds to the protein.	Hydrogen	150-158	MAS related GPR family member F	Homo sapiens	80-83
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Hydrogen	13-21	sucrase-isomaltase	Homo sapiens	61-78
27023502-5	2016	Textural, structural and surface properties of the prepared CdS nanostructures were determined and related to the activity results in the production of hydrogen from aqueous solutions containing SO3(2-) + S(2-) under visible light.	Hydrogen	152-160	CDP-diacylglycerol synthase 1	Homo sapiens	60-63
26879708-0	2016	CdS Nanowires Decorated with Ultrathin MoS2 Nanosheets as an Efficient Photocatalyst for Hydrogen Evolution.	Hydrogen	89-97	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
34315464-13	2021	Analysis of residue interactions across the interface between IHH and its interacting receptor protein revealed the presence of hydrogen bonds between them.	Hydrogen	128-136	Indian hedgehog signaling molecule	Homo sapiens	62-65
26879708-2	2016	An excellent hydrogen evolution rate of 1914 mumol  h(-1) (20 mg catalyst) under visible-light irradiation (lambda &gt;= 400 nm,   154 mW cm(-1) ) and an apparent quantum yield of 46.9% at lambda=420 nm were achieved over the MoS2 /CdS composite.	Hydrogen	13-21	CDP-diacylglycerol synthase 1	Homo sapiens	232-235
26879708-3	2016	The presence of ultrathin MoS2 nanosheets (rich in active edge sites) on the CdS surface promotes the separation of photogenerated charge carriers and facilitates the surface processes of photocatalytic hydrogen evolution.	Hydrogen	203-211	CDP-diacylglycerol synthase 1	Homo sapiens	77-80
34185506-5	2021	The preliminary application of Pd2/BP as a catalyst for the hydrogen evolution reaction (HER) in acidic medium highlighted an activity increase due to the presence of Pd2 units.	Hydrogen	60-68	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	31-37
26691211-0	2016	Surface Defects Enhanced Visible Light Photocatalytic H2 Production for Zn-Cd-S Solid Solution.	Hydrogen	54-56	CDP-diacylglycerol synthase 1	Homo sapiens	75-79
34185506-5	2021	The preliminary application of Pd2/BP as a catalyst for the hydrogen evolution reaction (HER) in acidic medium highlighted an activity increase due to the presence of Pd2 units.	Hydrogen	60-68	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	167-170
34102836-2	2021	Through a polarity matched hydrogen atom transfer (HAT) between an electrophilic radical and a formate salt, CO2 - formation occurs as a key element in a new radical chain reaction.	Hydrogen	27-35	complement C2	Homo sapiens	109-112
17728165-4	2007	Here the side chain of Asn88 (TM3) forms two pairs of hydrogen bonds with N3 and N9 of adenine while Asn146 (TM4) makes two pairs of hydrogen bonds with N1 and N6 of adenine.	Hydrogen	133-141	tropomyosin 4	Rattus norvegicus	109-112
17728165-7	2007	Guanine cannot make the hydrogen bond to Asn146 (TM4), leading to binding too weak to be observed experimentally.	Hydrogen	24-32	tropomyosin 4	Rattus norvegicus	49-52
17918813-1	2007	In this work, 11 adducts with hydrogen bonds were studied by using the B3LYP exchange-correlation functional of the Kohn-Sham approach and the Moller-Plesset second-order perturbation theory MP2.	Hydrogen	30-38	tryptase pseudogene 1	Homo sapiens	191-194
26833058-8	2016	Molecular docking assay was further performed to analyze the possible binding mode between polydatin and the PCSK9 crystal structure (PDB code: 2p4e), which indicated that steady hydrogen bonds formed between polydatin and PCSK9.	Hydrogen	179-187	proprotein convertase subtilisin/kexin type 9	Homo sapiens	109-114
17912398-0	2007	Zwitterionic pi-radical involving EDT-TTF-imidazole and F4TCNQ: redox properties and self-assembled structure by hydrogen-bonds and multiple S...S interactions.	Hydrogen	113-121	ras homolog family member H	Homo sapiens	38-41
17912398-1	2007	The reaction between an imidazole-functionalized EDT-TTF and F(4)TCNQ produced a zwitterionic pi-radical, which formed a self-assembled structure by the cooperation of hydrogen-bonds and multiple S...S interactions and exhibited three-step oxidation processes and a high electrical conductivity as a single-component organic molecule.	Hydrogen	168-176	ras homolog family member H	Homo sapiens	53-56
34235338-2	2021	Complexation of Fe(BF4)2 6H2O with each ligand (H2 L1 and H4 L2) in a methanolic-pyridine solution resulted in hexa-iron compounds (C1 and C2, respectively), which each contain two near-parallel metal triangles of (Fe3-mu3-O), linked by six fluoride bridges and stabilized by a hydrogen-bonded proton between the mu3-O groups.	Hydrogen	278-286	hexosaminidase subunit alpha	Homo sapiens	111-115
26833058-8	2016	Molecular docking assay was further performed to analyze the possible binding mode between polydatin and the PCSK9 crystal structure (PDB code: 2p4e), which indicated that steady hydrogen bonds formed between polydatin and PCSK9.	Hydrogen	179-187	proprotein convertase subtilisin/kexin type 9	Homo sapiens	223-228
34205141-8	2021	Both COF-1 and CTF-1 showed good surface properties for selective adsorption of water via hydrogen bonding and electrostatic interactions.	Hydrogen	90-98	cardiotrophin 1	Homo sapiens	15-20
26503547-4	2016	Single crystal X-ray diffraction analysis to 2.7 A resolution of Fv M6P-1 in complex with Man6P reveals that specificity and affinity is achieved via multiple hydrogen bonds to the mannose ring and two salt bridges to the phosphate moiety.	Hydrogen	159-167	trophoblast glycoprotein	Homo sapiens	68-73
34067839-2	2021	Our previous in silico work predicted three potential amino acids that bilirubin may interact with by hydrogen bonding in the PPARalpha ligand-binding domain (LBD), which could be responsible for the ligand-induced function.	Hydrogen	102-110	peroxisome proliferator activated receptor alpha	Homo sapiens	126-135
34121846-1	2021	The new benzimidazolium derivative (SM-1) salt with ion exchange from the (SM-0) was fabricated and characterized by proton-nuclear magnetic resonance (1H-NMR), carbon-nuclear magnetic resonance (13C-NMR), Fourier-transform infrared spectroscopy (FT-IR), electrospray ionization (EIS-MS), thermal analysis (TG), cyclic voltammetry (CV), and ultraviolet-visible spectroscopy (UV-vis), for electrolytes (liquid or dried) in the DSSC charge transportation mechanism.	Hydrogen	152-154	SM1	Homo sapiens	36-40
34275824-3	2021	Our previous study found that 5,6,7,8-trtrahydroxyflavone (5,6,7,8-THF), a flavones with four consecutive hydrogen group on ring A, showed excellent antioxidant properties in vitro.	Hydrogen	106-114	thin fur	Mus musculus	67-70
34453711-0	2021	Profiling Structural Alterations During Rab5 Nucleotide Exchange by HDX-MS. Hydrogen deuterium exchange mass spectrometry (HDX-MS) gives insight into the structure of proteins.	Hydrogen	76-84	RAB5A, member RAS oncogene family	Homo sapiens	40-44
34749602-13	2021	Molecular dynamics simulations for binding YWHAB and YWHAZ were conducted, and the complex was predicted to be energetically and structurally stable through its 3 hydrogen-bond patterns.	Hydrogen	163-171	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta	Homo sapiens	43-48
35397272-4	2022	The hydroxyl groups on the CNF surface promoted the association of hydrogen bonds between CLP, glycerol and CNF, which improved the crystal structure and thermal stability of PBBFs.	Hydrogen	67-75	calmodulin like 3	Homo sapiens	90-93
35568130-6	2022	We found that HLA molecules posing risks have a low affinity for the subunit beta2-microglobulin; notably, the weak hydrogen bond formed via Gln96 of the HLA molecule contributes to this behavior.	Hydrogen	116-124	beta-2-microglobulin	Homo sapiens	77-96
35367313-0	2022	PPARalpha contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression.	Hydrogen	51-59	brain derived neurotrophic factor	Mus musculus	137-141
35149868-4	2022	Modelled on the ESC hs-cTnT/I 0/1h-algorithms, we derived a 0/1h-cMyC-algorithm.	Hydrogen	62-64	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	65-69
17878976-1	2007	Short synthetic routes to a range of BEDT-TTF derivatives functionalised with two, four or eight hydroxyl groups are reported, of interest because of their potential for introducing hydrogen bonding between donor and anion into their radical cation salts.	Hydrogen	182-190	ras homolog family member H	Homo sapiens	42-45
17764690-3	2007	Hydrogen-exchange mass spectrometry was used to study the structural and conformational changes undergone by full-length human Hsp90beta in solution upon binding of the kinase-specific co-chaperone Cdc37 and two Hsp90 ATPase inhibitors: Radicicol and the first-generation anticancer drug DMAG.	Hydrogen	0-8	heat shock protein 90 alpha family class B member 1	Homo sapiens	127-136
17764690-3	2007	Hydrogen-exchange mass spectrometry was used to study the structural and conformational changes undergone by full-length human Hsp90beta in solution upon binding of the kinase-specific co-chaperone Cdc37 and two Hsp90 ATPase inhibitors: Radicicol and the first-generation anticancer drug DMAG.	Hydrogen	0-8	heat shock protein 90 alpha family class A member 1	Homo sapiens	127-132
17764690-4	2007	Changes in hydrogen exchange pattern in the complexes in regions of Hsp90 remote to the ligand-binding site were observed indicating long-range effects.	Hydrogen	11-19	heat shock protein 90 alpha family class A member 1	Homo sapiens	68-73
17766376-1	2007	Using the human Pin1 WW domain (hPin1 WW), we show that replacement of two nearest neighbor non-hydrogen-bonded residues on adjacent beta-strands with tryptophan (Trp) residues increases beta-sheet thermodynamic stability by 4.8 kJ mol(-1) at physiological temperature.	Hydrogen	96-104	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	16-20
17766376-1	2007	Using the human Pin1 WW domain (hPin1 WW), we show that replacement of two nearest neighbor non-hydrogen-bonded residues on adjacent beta-strands with tryptophan (Trp) residues increases beta-sheet thermodynamic stability by 4.8 kJ mol(-1) at physiological temperature.	Hydrogen	96-104	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	32-37
17513360-1	2007	We study the folding thermodynamics and kinetics of the Pin1 WW domain, a three-stranded beta-sheet protein, by using all-atom (except nonpolar hydrogens) discontinuous molecular dynamics simulations at various temperatures with a Go model.	Hydrogen	144-153	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	56-60
17718553-9	2007	The five hydrogen bonds between Arg24 in ShK and H404(A) and D402(D) in Kv1.3 make Arg24 the most crucial for its binding to the Kv1.3 channel.	Hydrogen	9-17	sedoheptulokinase	Mus musculus	41-44
17636966-1	2007	Oxidative addition of H2 to Ni(PH3)2 was theoretically studied as a prototype of nickel-catalyzed sigma-bond activation reaction, where CASSCF, CASPT2, CCSD(T), broken symmetry (Bs) MP2 to MP4(SDTQ), and DFT methods were employed.	Hydrogen	22-24	tryptase pseudogene 1	Homo sapiens	182-185
17582766-0	2007	Design, synthesis, and molecular modeling studies of 5"-deoxy-5"-ureidoadenosine: 5"-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase.	Hydrogen	110-118	adenosylhomocysteinase	Homo sapiens	155-187
17582766-1	2007	5"-Deoxy-5"-ureidoadenosine was designed and synthesized as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAH), in which 5"-ureido group acted as multiple hydrogen bonding donor in binding with active site residues of SAH in the molecular modeling study.	Hydrogen	165-173	adenosylhomocysteinase	Homo sapiens	82-114
17582766-1	2007	5"-Deoxy-5"-ureidoadenosine was designed and synthesized as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAH), in which 5"-ureido group acted as multiple hydrogen bonding donor in binding with active site residues of SAH in the molecular modeling study.	Hydrogen	165-173	adenosylhomocysteinase	Homo sapiens	116-119
17582766-1	2007	5"-Deoxy-5"-ureidoadenosine was designed and synthesized as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAH), in which 5"-ureido group acted as multiple hydrogen bonding donor in binding with active site residues of SAH in the molecular modeling study.	Hydrogen	165-173	adenosylhomocysteinase	Homo sapiens	228-231
17567734-4	2007	The drastic effect of mutations of Glu227, Arg247, Asp252, and Glu281 on GlcAT-I activity indicated a key role for the hydrogen bond network formed by these four conserved residues in dictating Gal2 binding.	Hydrogen	119-127	beta-1,3-glucuronyltransferase 3	Homo sapiens	73-80
17517377-7	2007	Based on these structure-activity relationship studies, we propose a model in which the modified tetrapeptide Trp-Nle-Tyr-Met (WNleYM) binds to FPRL1 through aromatic interactions involving the side chains of Trp(1) and Tyr(3), hydrophobic interaction of Nle(2), and the thio-based hydrogen bonding of Met(4), with the respective residues in FPRL1 which have not been identified.	Hydrogen	282-290	formyl peptide receptor 2	Homo sapiens	144-149
17517377-7	2007	Based on these structure-activity relationship studies, we propose a model in which the modified tetrapeptide Trp-Nle-Tyr-Met (WNleYM) binds to FPRL1 through aromatic interactions involving the side chains of Trp(1) and Tyr(3), hydrophobic interaction of Nle(2), and the thio-based hydrogen bonding of Met(4), with the respective residues in FPRL1 which have not been identified.	Hydrogen	282-290	tRNA-Pro (anticodon AGG) 2-5	Homo sapiens	209-215
17517377-7	2007	Based on these structure-activity relationship studies, we propose a model in which the modified tetrapeptide Trp-Nle-Tyr-Met (WNleYM) binds to FPRL1 through aromatic interactions involving the side chains of Trp(1) and Tyr(3), hydrophobic interaction of Nle(2), and the thio-based hydrogen bonding of Met(4), with the respective residues in FPRL1 which have not been identified.	Hydrogen	282-290	formyl peptide receptor 2	Homo sapiens	342-347
19636851-0	2007	1H, 13C and 15N resonance assignments for the small G protein RalB in its active conformation.	Hydrogen	0-2	RAS like proto-oncogene B	Homo sapiens	62-66
19636851-1	2007	We report 1H, 13C and 15N resonance assignments for the small G protein RalB in its active conformation.	Hydrogen	10-12	RAS like proto-oncogene B	Homo sapiens	72-76
17398049-5	2007	The primary interaction between PSA and indomethacin appears to be hydrogen bonding between the carboxylic acid OH of indomethacin and the carbonyl group of PSA.	Hydrogen	67-75	aminopeptidase puromycin sensitive	Homo sapiens	32-35
17398049-5	2007	The primary interaction between PSA and indomethacin appears to be hydrogen bonding between the carboxylic acid OH of indomethacin and the carbonyl group of PSA.	Hydrogen	67-75	aminopeptidase puromycin sensitive	Homo sapiens	157-160
17612735-5	2007	For the neon atom, the hydrogen molecule, and the hydrogen fluoride molecule, our calculations yield the most accurate MP2 energies published so far.	Hydrogen	23-31	tryptase pseudogene 1	Homo sapiens	119-122
17442338-4	2007	Indeed, in addition to the interactions found in all other AKRs (van der Waals contacts stabilizing the core of the steroid and the hydrogen bonds established at the catalytic site by the Y55 and H117 residues with the oxygen atom of the ketone group to be reduced), m17alpha-HSD establishes with the other extremity of the steroid nucleus an additional interaction involving K31.	Hydrogen	132-140	keratin 31	Mus musculus	376-379
17447732-14	2007	The dissociation rate constants and the slow-binding association rate constants for NAD+ show a complex temperature dependence with both enzymes; however, the cofactor always dissociates more rapidly from Tc-SAHH than from Hs-SAHH, the ratio being around 80-fold at 37 degrees C, and the cofactor binds more rapidly to Hs-SAHH than to Tc-SAHH above approximately 16 degrees C. These features present an opening for selective inhibition of Tc-SAHH over Hs-SAHH, demonstrated with the thioamide analogues of NAD+ and NADH.	Hydrogen	223-225	adenosylhomocysteinase	Homo sapiens	226-230
17447732-14	2007	The dissociation rate constants and the slow-binding association rate constants for NAD+ show a complex temperature dependence with both enzymes; however, the cofactor always dissociates more rapidly from Tc-SAHH than from Hs-SAHH, the ratio being around 80-fold at 37 degrees C, and the cofactor binds more rapidly to Hs-SAHH than to Tc-SAHH above approximately 16 degrees C. These features present an opening for selective inhibition of Tc-SAHH over Hs-SAHH, demonstrated with the thioamide analogues of NAD+ and NADH.	Hydrogen	223-225	adenosylhomocysteinase	Homo sapiens	226-230
17418825-5	2007	The treatment for 1h, for instance, activated Runx2, and type I collagen, while the treatment for 24h induced apoptosis.	Hydrogen	18-20	runt related transcription factor 2	Mus musculus	46-51
17367187-5	2007	The cis-1 bis(isobenzofuran) bisadducts 4b and 4e-j are kinetically far more stable toward thermal retro-Diels-Alder fragmentation than are mono(isobenzofuran) adducts of C60, in solution and in the solid state as determined by 1H NMR spectroscopy or thermogravimetric analysis.	Hydrogen	228-230	suppressor of cytokine signaling 1	Homo sapiens	4-9
17292862-2	2007	Molecular modeling of human CYP27A1 and docking with 25-hydroxyvitamin D(3) predicted that Gln 85 might be important for 1alpha-hydroxylation activity of CYP27A1 by forming a hydrogen bond with the 25-OH group of 25-hydroxyvitamin D(3).	Hydrogen	175-183	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	28-35
17292862-2	2007	Molecular modeling of human CYP27A1 and docking with 25-hydroxyvitamin D(3) predicted that Gln 85 might be important for 1alpha-hydroxylation activity of CYP27A1 by forming a hydrogen bond with the 25-OH group of 25-hydroxyvitamin D(3).	Hydrogen	175-183	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	154-161
17292862-6	2007	The fact that Q85L did not contain a heme molecule suggests that the hydrogen bond between Gln 85 and Asn 107 is important for protein folding of CYP27A1.	Hydrogen	69-77	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	146-153
17192259-0	2007	Cores and pH-dependent dynamics of ferredoxin-NADP+ reductase revealed by hydrogen/deuterium exchange.	Hydrogen	74-82	Ferredoxin--NADP reductase, embryo isozyme, chloroplastic-like	Zea mays	35-61
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM &lt; IC50 &lt; 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Hydrogen	221-229	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	190-193
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM &lt; IC50 &lt; 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Hydrogen	221-229	complement C2	Homo sapiens	205-208
17253669-3	2007	Stable isomers in the MP2/cc-pVDZ calculation were classified into a structure dominated only by the pi-pi interaction and structures formed by cooperation between the pi-pi interaction and hydrogen bonding.	Hydrogen	190-198	tryptase pseudogene 1	Homo sapiens	22-25
26612208-10	2016	In contrast, lesser structural and functional damage in the hippocampus was observed in the Sev 1h group.	Hydrogen	96-98	kallikrein 1-related peptidase C9	Rattus norvegicus	92-95
17279653-2	2007	Pd interaction with hydrogen leads to the formation of hydride PdHx, if critical conditions of pressure and temperature are reached (equilibrium hydrogen pressure over PdHx at 298 K is approximately 1 kPa).	Hydrogen	20-28	pyruvate dehydrogenase complex component X	Homo sapiens	63-67
35636290-5	2022	After optimization of the molten salt mass, the CoP/Co/C-6 shows the best bifunctional performance, requiring an overpotential of 132 mV and 320 mV at 10 mA cm-2 for hydrogen evolution reaction and oxygen evolution reaction, respectively.	Hydrogen	166-174	caspase recruitment domain family member 16	Homo sapiens	48-51
17279653-2	2007	Pd interaction with hydrogen leads to the formation of hydride PdHx, if critical conditions of pressure and temperature are reached (equilibrium hydrogen pressure over PdHx at 298 K is approximately 1 kPa).	Hydrogen	20-28	pyruvate dehydrogenase complex component X	Homo sapiens	168-172
26111963-7	2016	This suggests that growth of strain MFA1 could be enhanced by a reduction of hydrogen partial pressure as a result of hydrogen removal by a methanogen or reduction of fluoroacetate.	Hydrogen	77-85	mating pheromone a	Saccharomyces cerevisiae S288C	36-40
17279653-2	2007	Pd interaction with hydrogen leads to the formation of hydride PdHx, if critical conditions of pressure and temperature are reached (equilibrium hydrogen pressure over PdHx at 298 K is approximately 1 kPa).	Hydrogen	145-153	pyruvate dehydrogenase complex component X	Homo sapiens	63-67
17279653-2	2007	Pd interaction with hydrogen leads to the formation of hydride PdHx, if critical conditions of pressure and temperature are reached (equilibrium hydrogen pressure over PdHx at 298 K is approximately 1 kPa).	Hydrogen	145-153	pyruvate dehydrogenase complex component X	Homo sapiens	168-172
35595714-2	2022	Herein, one nickel nitride-based heterostructure composed of 1D Ni0.2 Mo0.8 N nanorods and 0D Ni3 N nanoparticles (denoted as NiMoN/NiN) is reported to exhibit significantly promoted hydrogen evolution reaction performance in both alkaline and neutral media.	Hydrogen	183-191	ninein	Homo sapiens	132-135
35512324-3	2022	In this report, an ammonium thiomolybdate (ATM: (NH4)2Mo3S13) is evaluated as a p-type semiconductor film photocathode for hydrogen evolution reaction.	Hydrogen	123-131	ATM serine/threonine kinase	Homo sapiens	43-46
35512324-6	2022	Furthermore, the photovoltage of the ATM thin films measured by TSPV is correlated to the photocurrents measured by the PEC characterization that can be used to evaluate the material potential for hydrogen generation.	Hydrogen	197-205	ATM serine/threonine kinase	Homo sapiens	37-40
17123727-6	2007	IL-18 (100 ng/ml) applied for 20 min before-HFS had no significant effect on baseline EPSPs but significantly impaired LTP (IL-18 LTP 116+/-9%, versus control LTP 163+/-6% 1h post-tetanus, P&lt;0.001, n=5).	Hydrogen	172-174	interleukin 18	Rattus norvegicus	0-5
35512324-9	2022	The reason for such a strong charge carrier transfer effect for ATM/WSe2 heterojunction photocathodes is studied by TSPV spectroscopy that allows a comprehensive evaluation of potential photovoltaic materials toward PEC hydrogen production.	Hydrogen	220-228	ATM serine/threonine kinase	Homo sapiens	64-67
17123727-8	2007	Perfusion of the group II mGluR antagonist MTPG (50 microM) for 40 min prior to application of IL-18 had no significant effect on baseline EPSPs but was found to significantly reverse the inhibitory effect of IL-18 on LTP at 1h (164+/-6% compared to IL-18 alone, n=5).	Hydrogen	225-227	interleukin 18	Rattus norvegicus	209-214
17123727-8	2007	Perfusion of the group II mGluR antagonist MTPG (50 microM) for 40 min prior to application of IL-18 had no significant effect on baseline EPSPs but was found to significantly reverse the inhibitory effect of IL-18 on LTP at 1h (164+/-6% compared to IL-18 alone, n=5).	Hydrogen	225-227	interleukin 18	Rattus norvegicus	209-214
26111963-7	2016	This suggests that growth of strain MFA1 could be enhanced by a reduction of hydrogen partial pressure as a result of hydrogen removal by a methanogen or reduction of fluoroacetate.	Hydrogen	118-126	mating pheromone a	Saccharomyces cerevisiae S288C	36-40
35634373-7	2022	Hydrogen bonds and van der Waals were the predominant forces to maintain the complex of myricetin with DPP-4, and electrostatic forces might play an important role in stabilizing the complexes of the remaining four flavonoids with DPP-4.	Hydrogen	0-8	dipeptidyl peptidase 4	Homo sapiens	103-108
26932067-4	2016	To produce the H2(+), we are currently developing a dedicated multicusp ion source, MIST-1 (generation-1 Multicusp Ion Source Technologies at MIT), and a low-energy beam transport system for the IsoDAR cyclotron.	Hydrogen	15-20	basic helix-loop-helix family member a15	Homo sapiens	84-90
35615519-9	2022	Molecular docking suggested the hydrogen bond between the pCA carboxyl group and Elongation factor Tu Asn-64 might contribute to deamidation.	Hydrogen	32-40	elongation factor Tu	Cronobacter sakazakii	81-101
35341785-8	2022	Additionally, western blotting results showed that hydrogen inhalation inhibited the expression of cardiac nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2), angiotensin II type 1 receptor, sarcoplasmic reticulum Ca2+-ATPase (SERCA2), phospho-phospholamban and alpha-myosin heavy chain proteins.	Hydrogen	51-59	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	237-243
35513390-6	2022	For Ir1/VO-CoOOH, a hydrogen bonding is formed between the coordinated oxygen of single-atom Ir center and the oxygenated intermediates, which stabilizes the intermediates and lowers the energy barrier of the rate-determining step.	Hydrogen	20-28	nischarin	Homo sapiens	4-7
35469395-0	2022	Superhydrophilic/Superaerophobic Hierarchical NiP2@MoO2/Co(Ni)MoO4 Core-Shell Array Electrocatalysts for Efficient Hydrogen Production at Large Current Densities.	Hydrogen	115-123	BCL2 interacting protein 2	Homo sapiens	46-50
35319113-4	2022	The obtained Ru1,n -NC exhibits ultralow overpotential (14.8 mV) and high turnover frequency (1.25 H2 s-1 at -0.025 V versus reversible hydrogen electrode); much better than the commercial 40 wt% Pt/C.	Hydrogen	136-144	Scm like with four mbt domains 1	Homo sapiens	13-16
35319113-6	2022	Eventually; the electronic regulations bring accelerated water dissociation and reduced energy barriers of hydroxide/hydrogen desorption on adjacent Ru sites; then an optimized reaction kinetics for Ru1,n -NC is obtained to achieve superb hydrogen generation in alkaline media.	Hydrogen	117-125	Scm like with four mbt domains 1	Homo sapiens	199-202
35319113-6	2022	Eventually; the electronic regulations bring accelerated water dissociation and reduced energy barriers of hydroxide/hydrogen desorption on adjacent Ru sites; then an optimized reaction kinetics for Ru1,n -NC is obtained to achieve superb hydrogen generation in alkaline media.	Hydrogen	239-247	Scm like with four mbt domains 1	Homo sapiens	199-202
35320738-6	2022	The stability of YPW-iNOS was maintained by the hydrogen bonds of amino acid residues Ile195, Gly196, Gly365, Glu371, Asn364, and Trp366, and the hydrophobic interactions by Trp188, Phe363, and Val346.	Hydrogen	48-56	inositol-3-phosphate synthase 1	Homo sapiens	21-25
35065439-0	2022	A high efficiency water hydrogen production method based on CdS/WN composite photocatalytic.	Hydrogen	24-32	CDP-diacylglycerol synthase 1	Homo sapiens	60-63
35065439-2	2022	In this paper, WN with excellent electrical conductivity was selected as a new noble-metal-free co-catalyst to improve the photoreduction hydrogen (H2) evolution performance of CdS nanoparticles (NPs).	Hydrogen	138-146	CDP-diacylglycerol synthase 1	Homo sapiens	177-180
35066234-7	2022	Owing to the synergistic effects of VO and Z-scheme systems, the optimized MnO2-x/CdS photocatalyst displays a dramatically enhanced photocatalytic activity with an O2 production rate of 779 mumol g-1h-1 under visible-light irradiation without any cocatalysts, which is 2.33 times higher than the bare MnO2-x.	Hydrogen	199-201	CDP-diacylglycerol synthase 1	Homo sapiens	82-85
35074704-3	2022	The visible and near-infrared light driven photocatalytic hydrogen evolution rate is up to 3420 mumol h-1 g-1, and the removal ratio of organic contaminant methylene blue is up to 98% within 70 min, which is several times higher than that of pristine graphitic carbon nitride and DCN.	Hydrogen	58-66	decorin	Homo sapiens	280-283
35307397-4	2022	To understand how LPL binds ANGPTL3/8 and ApoA5 blocks this interaction, we used hydrogen-deuterium exchange mass-spectrometry (HDXMS) and molecular modeling to map binding sites of LPL and ApoA5 on ANGPTL3/8.	Hydrogen	81-89	lipoprotein lipase	Homo sapiens	18-21
35307397-4	2022	To understand how LPL binds ANGPTL3/8 and ApoA5 blocks this interaction, we used hydrogen-deuterium exchange mass-spectrometry (HDXMS) and molecular modeling to map binding sites of LPL and ApoA5 on ANGPTL3/8.	Hydrogen	81-89	lipoprotein lipase	Homo sapiens	182-185
35445555-5	2022	Compared to measurements using bare nano-gap, it is found that MAA modification improves the difference in the conductance-time profiles between Asp and Leu through the hydrogen bonding facilitated tunneling phenomena.	Hydrogen	169-177	assembly factor for spindle microtubules	Homo sapiens	145-148
35380571-3	2022	Unlike homotrimeric helices, the CLP heterotrimeric triple helices in this study are made of CLP strands of different chain lengths that result in "sticky" ends with available hydrogen bonding groups.	Hydrogen	176-184	calmodulin like 3	Homo sapiens	33-36
35380571-3	2022	Unlike homotrimeric helices, the CLP heterotrimeric triple helices in this study are made of CLP strands of different chain lengths that result in "sticky" ends with available hydrogen bonding groups.	Hydrogen	176-184	calmodulin like 3	Homo sapiens	93-96
35380571-4	2022	These "sticky" ends at one end or both ends of the CLP heterotrimer then facilitate inter-helix hydrogen bonding leading to self-assembly into fibrils (clusters) and percolated networks.	Hydrogen	96-104	calmodulin like 3	Homo sapiens	51-54
35380571-7	2022	At higher CLP concentrations, we observe non-monotonic trends in cluster sizes with increasing sticky end length with one sticky end but not for two sticky ends with the same number of available hydrogen bonding groups as the one sticky end; this nonmonotonicity stems from the formation of turn structures stabilized by hydrogen bonds at the single, sticky end for sticky end lengths greater than four repeat units.	Hydrogen	195-203	calmodulin like 3	Homo sapiens	10-13
35380571-7	2022	At higher CLP concentrations, we observe non-monotonic trends in cluster sizes with increasing sticky end length with one sticky end but not for two sticky ends with the same number of available hydrogen bonding groups as the one sticky end; this nonmonotonicity stems from the formation of turn structures stabilized by hydrogen bonds at the single, sticky end for sticky end lengths greater than four repeat units.	Hydrogen	321-329	calmodulin like 3	Homo sapiens	10-13
35429283-5	2022	Molecular modeling studies also confirmed possible mode of interaction between 6u and the binding sites of HSP90 by hydrogen bond and hydrophobic interactions.	Hydrogen	116-124	heat shock protein 90 alpha family class A member 1	Homo sapiens	107-112
35272236-6	2022	The docking study supported that compound 5n binds to PAK4 through various hydrogen bonding interactions and hydrophobic interactions.	Hydrogen	75-83	p21 (RAC1) activated kinase 4	Homo sapiens	54-58
35453457-6	2022	In silico molecule docking showed that tannins were bound to the active site of tyrosinase via hydrogen and electrovalent bonds.	Hydrogen	95-103	tyrosinase	Mus musculus	80-90
35343533-0	2022	In situ growth of MOF-derived sulfur vacancy-rich CdS nanoparticles on 2D polymers for highly efficient photocatalytic hydrogen generation.	Hydrogen	119-127	CDP-diacylglycerol synthase 1	Homo sapiens	50-53
35343533-8	2022	As a result, the 18%CdS(MOF)/PI heterojunction exhibited a higher hydrogen evolution rate of 8640 mumol g-o after 4 hours of illumination, which was 20 times higher than that of 18%CdS/PI under visible light irradiation.	Hydrogen	66-74	CDP-diacylglycerol synthase 1	Homo sapiens	20-23
35343533-8	2022	As a result, the 18%CdS(MOF)/PI heterojunction exhibited a higher hydrogen evolution rate of 8640 mumol g-o after 4 hours of illumination, which was 20 times higher than that of 18%CdS/PI under visible light irradiation.	Hydrogen	66-74	CDP-diacylglycerol synthase 1	Homo sapiens	181-184
35347335-5	2022	By computing the energetics of C-H bond activation and mapping the potential energy surface, it was found that the initial hydrogen abstraction is the rate-determining step with both TMC rings and all the studied metal-superoxo species.	Hydrogen	123-131	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	183-186
35458602-7	2022	The molecular docking simulation indicated that the binding pattern of 3s into PI3Kgamma was preferable than that of PI3Kalpha, with more hydrogen bond, more pi-involved interactions, and fewer pi-sulfur interactions.	Hydrogen	138-146	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	79-88
35333511-5	2022	Moreover, Ru1+NPs/N-C shows comparable hydrogen production performance and a higher faradic efficiency to 20% Pt/C in natural seawater and artificial simulated seawater.	Hydrogen	39-47	Scm like with four mbt domains 1	Homo sapiens	10-13
35040208-0	2022	Crystalline-Amorphous Interfaces Coupling of CoSe2 /CoP with Optimized d-band Center and Boosted Electrocatalytic Hydrogen Evolution.	Hydrogen	114-122	caspase recruitment domain family member 16	Homo sapiens	52-55
17541996-2	2007	Examination of the 31P-{1H} NMR spectrum of a solution (CH2Cl(2)) of [Et4C4P-(PPh3)]+ and PPh3 revealed broadening of the resonances due to both free and coordinated PPh3, and importantly it proved possible to measure the rate of exchange between PPh3 and [Et4C4P-(PPh3)]+ by line shape analysis (gNMR programmes).	Hydrogen	24-26	protein phosphatase 4 catalytic subunit	Homo sapiens	78-82
17541996-2	2007	Examination of the 31P-{1H} NMR spectrum of a solution (CH2Cl(2)) of [Et4C4P-(PPh3)]+ and PPh3 revealed broadening of the resonances due to both free and coordinated PPh3, and importantly it proved possible to measure the rate of exchange between PPh3 and [Et4C4P-(PPh3)]+ by line shape analysis (gNMR programmes).	Hydrogen	24-26	protein phosphatase 4 catalytic subunit	Homo sapiens	90-94
17541996-2	2007	Examination of the 31P-{1H} NMR spectrum of a solution (CH2Cl(2)) of [Et4C4P-(PPh3)]+ and PPh3 revealed broadening of the resonances due to both free and coordinated PPh3, and importantly it proved possible to measure the rate of exchange between PPh3 and [Et4C4P-(PPh3)]+ by line shape analysis (gNMR programmes).	Hydrogen	24-26	protein phosphatase 4 catalytic subunit	Homo sapiens	90-94
17541996-2	2007	Examination of the 31P-{1H} NMR spectrum of a solution (CH2Cl(2)) of [Et4C4P-(PPh3)]+ and PPh3 revealed broadening of the resonances due to both free and coordinated PPh3, and importantly it proved possible to measure the rate of exchange between PPh3 and [Et4C4P-(PPh3)]+ by line shape analysis (gNMR programmes).	Hydrogen	24-26	protein phosphatase 4 catalytic subunit	Homo sapiens	90-94
17541996-2	2007	Examination of the 31P-{1H} NMR spectrum of a solution (CH2Cl(2)) of [Et4C4P-(PPh3)]+ and PPh3 revealed broadening of the resonances due to both free and coordinated PPh3, and importantly it proved possible to measure the rate of exchange between PPh3 and [Et4C4P-(PPh3)]+ by line shape analysis (gNMR programmes).	Hydrogen	24-26	protein phosphatase 4 catalytic subunit	Homo sapiens	90-94
17158006-10	2007	EPO was injected intraperitoneally 1h before noise exposure.	Hydrogen	35-37	erythropoietin	Rattus norvegicus	0-3
17264539-8	2007	Intraperitoneal administration of H2-Db/Uty tetramers to primed C57BL/6 mice produced over 5-fold expansion of Db/Uty-specific CTL in vivo.	Hydrogen	34-36	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	Mus musculus	40-43
17264539-8	2007	Intraperitoneal administration of H2-Db/Uty tetramers to primed C57BL/6 mice produced over 5-fold expansion of Db/Uty-specific CTL in vivo.	Hydrogen	34-36	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	Mus musculus	114-117
17083236-4	2006	In the crystal structure of (PPh4)2[Mo(IV)O(Se-2-CH3CONHC6H4)4], an NH...O=Mo hydrogen bond was found.	Hydrogen	78-86	potassium two pore domain channel subfamily K member 3	Homo sapiens	29-33
17177888-2	2006	The flexing and/or torsion-derived forces exerted on the elbow region in Fab arms of bivalent antibodies upon binding to antigen were assumed to drive the disruption of hydrogen bonds which stabilize N- and C-terminal chain fragments in V-domains.	Hydrogen	169-177	FA complementation group B	Homo sapiens	73-76
17260753-3	2006	The differences in isomer structures of the trans and cis-1,2-dicyano-(p-ethylphenyl)alkenes were represented by the obvious differences in the spectra of UV-Vis, FTIR and 1H NMR In addition, the reasons for the differences were also analyzed.	Hydrogen	172-174	suppressor of cytokine signaling 1	Homo sapiens	54-59
17075963-4	2006	1H NMR spectroscopy of myoglobin (Mb) monitors intramyocytic oxygenation.	Hydrogen	0-2	myoglobin	Homo sapiens	23-32
17075963-4	2006	1H NMR spectroscopy of myoglobin (Mb) monitors intramyocytic oxygenation.	Hydrogen	0-2	myoglobin	Homo sapiens	34-36
17029455-5	2006	We explain our observations through a mechanism which is initiated by the isomerization of 1CH3N to a highly internally excited methanimine H2C=NH isomer, which decomposes by 1,1-H2 elimination forming HNC+H2 as well as sequential H-atom loss (N-H followed by C-H bond cleavage), to form HCN.	Hydrogen	140-142	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	288-291
16928055-3	2006	Both the absolute and relative stereochemistry of milbemycin beta3 was introduced by two Sharpless asymmetric dihydroxylations, two pi-allylpalladium-catalyzed reductions, and an iridium-catalyzed hydrogen migration/Claisen rearrangement to install the C-12 stereocenter.	Hydrogen	197-205	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	61-66
16724365-0	2006	Stereoelectronic and inductive effects on 1H and 13C NMR chemical shifts of some cis-1,3-disubstituted cyclohexanes.	Hydrogen	42-44	suppressor of cytokine signaling 1	Homo sapiens	81-86
16724365-5	2006	The beta-effect of the analyzed compounds showed that the chemical shift of hydrogens at C-2 and C-4 increases with the decrease of n(Y) --&gt; *sigma(C2-C3) and n(Y) --&gt; *sigma(C3-C4) interaction energies, respectively, showing a behavior similar to H-3.	Hydrogen	76-85	complement C2	Homo sapiens	89-92
16724365-5	2006	The beta-effect of the analyzed compounds showed that the chemical shift of hydrogens at C-2 and C-4 increases with the decrease of n(Y) --&gt; *sigma(C2-C3) and n(Y) --&gt; *sigma(C3-C4) interaction energies, respectively, showing a behavior similar to H-3.	Hydrogen	76-85	complement C4A (Rodgers blood group)	Homo sapiens	97-100
16810729-4	2006	In addition to exchangeable water protons, the 1H ENDOR method is also sensitive to other exchangeable protons, and it is shown here that this method can overestimate hydration numbers for complexes with exchangeable protons at GdH distances similar to that of the coordinated water, for example, from NH groups.	Hydrogen	47-49	glutamate dehydrogenase 1	Homo sapiens	228-231
16801540-6	2006	Hydrogen/deuterium exchange (HDX) coupled to liquid chromatography-electrospray ionization MS demonstrated a marked reduction in deuterium incorporation in both beta-and alpha-tubulin when Taxol was present.	Hydrogen	0-8	tubulin alpha 1b	Homo sapiens	161-183
16894785-5	2006	From these results, the two N-H hydrogens of the amide tethers of CSP 1, the carbonyl oxygen of the amide group of analytes, and the nitro group on the benzoyl group of analytes were concluded to play significant roles in chiral recognition.	Hydrogen	32-41	regulator of calcineurin 1	Homo sapiens	66-71
16819268-3	2006	1H-NMR spectra of DMA analogues and their Co(III) complexes were first measured and analyzed to elucidate the structures of metal complexes.	Hydrogen	0-2	cyclin 3	Zea mays	42-49
16819715-8	2006	The detailed description of the intramolecular hydrogen bonds, hydration, and intermolecular hydrogen bonds taking place in bFGF and its mutants in the presence of ethanol established that the residues belonging to the beta5 and beta9 strands, especially SER-73(beta5), TYR-112(beta9), THR-114(beta9), TYR-115(beta9), and SER-117(beta9), are the regions most affected by the presence of ethanol molecules in solution.	Hydrogen	47-55	adaptor related protein complex 5 subunit beta 1	Homo sapiens	219-234
16819715-8	2006	The detailed description of the intramolecular hydrogen bonds, hydration, and intermolecular hydrogen bonds taking place in bFGF and its mutants in the presence of ethanol established that the residues belonging to the beta5 and beta9 strands, especially SER-73(beta5), TYR-112(beta9), THR-114(beta9), TYR-115(beta9), and SER-117(beta9), are the regions most affected by the presence of ethanol molecules in solution.	Hydrogen	93-101	adaptor related protein complex 5 subunit beta 1	Homo sapiens	219-234
16574417-13	2006	Docking analyses of the interaction between DR396 and DNase gamma revealed that DR396 binds tightly to three subsites (S1, S2, and S3) in the trapping site of DNase gamma by forming six hydrogen bonds, whereas DF365 and the partial structures are unable to form hydrogen bonds at all three subsites.	Hydrogen	186-194	deoxyribonuclease 1 like 3	Homo sapiens	54-65
16574417-13	2006	Docking analyses of the interaction between DR396 and DNase gamma revealed that DR396 binds tightly to three subsites (S1, S2, and S3) in the trapping site of DNase gamma by forming six hydrogen bonds, whereas DF365 and the partial structures are unable to form hydrogen bonds at all three subsites.	Hydrogen	186-194	deoxyribonuclease 1 like 3	Homo sapiens	159-170
16574417-13	2006	Docking analyses of the interaction between DR396 and DNase gamma revealed that DR396 binds tightly to three subsites (S1, S2, and S3) in the trapping site of DNase gamma by forming six hydrogen bonds, whereas DF365 and the partial structures are unable to form hydrogen bonds at all three subsites.	Hydrogen	262-270	deoxyribonuclease 1 like 3	Homo sapiens	54-65
16574417-13	2006	Docking analyses of the interaction between DR396 and DNase gamma revealed that DR396 binds tightly to three subsites (S1, S2, and S3) in the trapping site of DNase gamma by forming six hydrogen bonds, whereas DF365 and the partial structures are unable to form hydrogen bonds at all three subsites.	Hydrogen	262-270	deoxyribonuclease 1 like 3	Homo sapiens	159-170
16771432-5	2006	The SDS-PAGE results proved that the electron tunneling between Mb and gelatine was noncovalent hydrogen bonds.	Hydrogen	96-104	myoglobin	Homo sapiens	64-66
35362514-8	2022	IL-1beta and IL-6 were up-regulated after 1h, but IL-1beta decreased right after 3h, while IL-6 sustained up-regulation throughout all time points.	Hydrogen	42-44	interleukin 1 alpha	Homo sapiens	0-8
35362514-8	2022	IL-1beta and IL-6 were up-regulated after 1h, but IL-1beta decreased right after 3h, while IL-6 sustained up-regulation throughout all time points.	Hydrogen	42-44	interleukin 1 alpha	Homo sapiens	50-58
35286059-6	2022	In particular, two hydrogen atoms precovered on Pt1-C1N2, resulting in a lower energy barrier for the rate-limiting step than that on Pt1-C2N1.	Hydrogen	19-27	zinc finger protein 77	Homo sapiens	48-51
35286059-6	2022	In particular, two hydrogen atoms precovered on Pt1-C1N2, resulting in a lower energy barrier for the rate-limiting step than that on Pt1-C2N1.	Hydrogen	19-27	zinc finger protein 77	Homo sapiens	134-137
35245026-0	2022	Polytypic Phase Transition of Nb1-xVxSe2 via Colloidal Synthesis and Their Catalytic Activity toward Hydrogen Evolution Reaction.	Hydrogen	101-109	CD177 molecule	Homo sapiens	30-33
26700190-3	2016	In both systems, the initial interaction occurs through unconventional CH(delta+)   N ionic hydrogen bonds between the hydrogen atoms of the naphthalene cation and the lone pair of electrons on the N atom of the HCN or the CH3CN molecule.	Hydrogen	92-100	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	212-215
35229097-2	2022	The rigidity, symmetry and high density of hydrogen bonding motifs make 1 an attractive candidate for self-assembly study, which revealed different hydrogen bond patterns in the crystals of rac-1-d3 and (+)-(SSS)-1.	Hydrogen	43-51	sodium voltage-gated channel alpha subunit 5	Homo sapiens	203-214
35229097-2	2022	The rigidity, symmetry and high density of hydrogen bonding motifs make 1 an attractive candidate for self-assembly study, which revealed different hydrogen bond patterns in the crystals of rac-1-d3 and (+)-(SSS)-1.	Hydrogen	148-156	sodium voltage-gated channel alpha subunit 5	Homo sapiens	203-214
16706410-13	2006	In addition, the nitrogen atoms in 2-4 are predicted to attain basicities in the range 920-950 kJ/mol, making them basic enough to be the preferred site for hydrogen bonding in the Pin-1 active site, in support of the proposed mechanism for PPIases.	Hydrogen	157-165	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	181-186
16669626-4	2006	The resulting reaction pathways, found in the catalytically competent closed/closed conformation of the Switch-1/Switch-2 loops of myosin, are all associative with a pentavalent bipyramidal oxyphosphorane transition state but can vary in the activation mechanism of the attacking water molecule and in the way the hydrogens are transferred between the heavy atoms.	Hydrogen	314-323	myosin heavy chain 14	Homo sapiens	131-137
26700190-5	2016	On the other hand, HCN can form both unconventional hydrogen bonds with the hydrogen atoms of the naphthalene cation (CH(delta+)   NCH), and conventional linear hydrogen bonding chains involving HCN   HCN interactions among the associated HCN molecules.	Hydrogen	52-60	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	19-22
16637621-0	2006	Hydride transfer versus hydrogen radical transfer in thymidylate synthase.	Hydrogen	24-32	thymidylate synthetase	Homo sapiens	53-73
35238538-4	2022	There are three kinds of synergetic physical cross-links among our polyamphion hydrogels: (1) double hydrogen bonds between amide groups in NAGA to provide toughness, (2) hydrogen bonds between dual bisphosphite groups in AcAln, and (3) weak ionic pairs between the anionic bisphosphite groups and the cationic quaternary ammonium groups in DMAEA-Q to offer flexibility.	Hydrogen	101-109	alpha-N-acetylgalactosaminidase	Rattus norvegicus	140-144
26700190-5	2016	On the other hand, HCN can form both unconventional hydrogen bonds with the hydrogen atoms of the naphthalene cation (CH(delta+)   NCH), and conventional linear hydrogen bonding chains involving HCN   HCN interactions among the associated HCN molecules.	Hydrogen	76-84	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	19-22
35291773-7	2022	We measure that the TOF for ECH of phenol increases as the Rh nanoparticle diameter increases from 2 to 10 nm at 298 K and -0.1 V vs the reversible hydrogen electrode, qualitatively matching prior reports for Pt nanoparticles.	Hydrogen	148-156	FEZ family zinc finger 2	Homo sapiens	20-23
16633663-4	2006	The coupling constants and the absolute frequency of the hydrogen bonded stretch mode are in excellent agreement with theoretical predictions based on adiabatic variational calculations on potential surfaces computed at MP2 and CCSD(T) level.	Hydrogen	57-65	tryptase pseudogene 1	Homo sapiens	220-223
26700190-5	2016	On the other hand, HCN can form both unconventional hydrogen bonds with the hydrogen atoms of the naphthalene cation (CH(delta+)   NCH), and conventional linear hydrogen bonding chains involving HCN   HCN interactions among the associated HCN molecules.	Hydrogen	76-84	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	195-198
35277567-3	2022	From the nuclear magnetic resonance results, the crystallographic configurations of 1H, 13C, and 14N in the cation changed at temperatures close to TC1 (336 K), whereas that of 113Cd in the anion shows significant changes at temperatures close to TC1 and TC2 (417 K).	Hydrogen	84-86	transcobalamin 1	Homo sapiens	148-151
26700190-5	2016	On the other hand, HCN can form both unconventional hydrogen bonds with the hydrogen atoms of the naphthalene cation (CH(delta+)   NCH), and conventional linear hydrogen bonding chains involving HCN   HCN interactions among the associated HCN molecules.	Hydrogen	76-84	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	19-22
35277567-3	2022	From the nuclear magnetic resonance results, the crystallographic configurations of 1H, 13C, and 14N in the cation changed at temperatures close to TC1 (336 K), whereas that of 113Cd in the anion shows significant changes at temperatures close to TC1 and TC2 (417 K).	Hydrogen	84-86	transcobalamin 1	Homo sapiens	247-250
35277567-4	2022	The activation energy, Ea, values for 1H and 13C obtained from the spin-lattice relaxation time, T1rho, below and above TC1 were evaluated, where the Ea value for 13C was more flexible at low temperatures than at high temperatures.	Hydrogen	38-40	transcobalamin 1	Homo sapiens	120-123
26700190-5	2016	On the other hand, HCN can form both unconventional hydrogen bonds with the hydrogen atoms of the naphthalene cation (CH(delta+)   NCH), and conventional linear hydrogen bonding chains involving HCN   HCN interactions among the associated HCN molecules.	Hydrogen	76-84	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	195-198
26700190-6	2016	HCN molecules tend to form "externally solvated" structures with the naphthalene cation where the naphthalene ion is hydrogen bonded to the exterior of an HCN   HCN chain.	Hydrogen	117-125	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-3
26527737-4	2016	Using hydrogen/deuterium exchange mass spectrometry (HDX-MS) and biophysical assays, we show that both the N-terminal extension of PTEN-L and C-terminal tail of PTEN affect the phosphatase activity using unique mechanisms.	Hydrogen	6-14	phosphatase and tensin homolog	Homo sapiens	131-135
35432866-1	2022	Hydrogen (11C)cyanide ((11C)HCN) is a versatile 11C-labelling agent for the production of 11C-labelled compounds used for positron emission tomography (PET).	Hydrogen	0-8	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	28-31
35300173-0	2022	Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway.	Hydrogen	19-27	heme oxygenase 1	Homo sapiens	112-116
35300173-11	2022	Besides, hydrogen-rich medium relieved the oxidative stress via the activation of the Nrf-2/heme oxygenase-1 (HO-1) pathway.	Hydrogen	9-17	heme oxygenase 1	Homo sapiens	92-108
35300173-11	2022	Besides, hydrogen-rich medium relieved the oxidative stress via the activation of the Nrf-2/heme oxygenase-1 (HO-1) pathway.	Hydrogen	9-17	heme oxygenase 1	Homo sapiens	110-114
35300173-13	2022	Hydrogen relieves the oxidative stress in the wound microenvironment via Nrf-2/HO-1 signaling pathway.	Hydrogen	0-8	heme oxygenase 1	Homo sapiens	79-83
16522124-1	2006	High-level quantum chemistry calculations have been used to examine the hydrogen-abstraction reactions of diol dehydratase (DDH) in the context of both the catalytic mechanism and the enzyme dysfunction phenomenon termed suicide inactivation.	Hydrogen	72-80	aldo-keto reductase family 1 member C1	Homo sapiens	124-127
26527737-4	2016	Using hydrogen/deuterium exchange mass spectrometry (HDX-MS) and biophysical assays, we show that both the N-terminal extension of PTEN-L and C-terminal tail of PTEN affect the phosphatase activity using unique mechanisms.	Hydrogen	6-14	phosphatase and tensin homolog	Homo sapiens	161-165
16503639-6	2006	In addition, it was suggested that the hydrogen bond of the Schiff base is weaker in squid rhodopsin than in bacteriorhodopsin and bovine rhodopsin, and squid rhodopsin possessed similar hydrogen bonding strength for the Schiff base among rhodopsin, Iso, and bathorhodopsin.	Hydrogen	39-47	rhodopsin	Bos taurus	91-100
16503639-6	2006	In addition, it was suggested that the hydrogen bond of the Schiff base is weaker in squid rhodopsin than in bacteriorhodopsin and bovine rhodopsin, and squid rhodopsin possessed similar hydrogen bonding strength for the Schiff base among rhodopsin, Iso, and bathorhodopsin.	Hydrogen	39-47	rhodopsin	Bos taurus	117-126
26595324-6	2016	Thus, the transition temperature of ELPs in pure water is determined by two factors: the hydrogen bonding tendency of the pentamers and the number of pentamers per ELP.	Hydrogen	89-97	nuclear receptor subfamily 5 group A member 1	Homo sapiens	36-39
16503639-6	2006	In addition, it was suggested that the hydrogen bond of the Schiff base is weaker in squid rhodopsin than in bacteriorhodopsin and bovine rhodopsin, and squid rhodopsin possessed similar hydrogen bonding strength for the Schiff base among rhodopsin, Iso, and bathorhodopsin.	Hydrogen	39-47	rhodopsin	Bos taurus	117-126
16503639-6	2006	In addition, it was suggested that the hydrogen bond of the Schiff base is weaker in squid rhodopsin than in bacteriorhodopsin and bovine rhodopsin, and squid rhodopsin possessed similar hydrogen bonding strength for the Schiff base among rhodopsin, Iso, and bathorhodopsin.	Hydrogen	39-47	rhodopsin	Bos taurus	117-126
16503639-7	2006	Most vibrational bands in the X-D stretch region originate from water O-D or the Schiff base N-D stretches, suggesting that the hydrogen bonding network in the Schiff base region of squid rhodopsin is composed of only water molecules.	Hydrogen	128-136	rhodopsin	Bos taurus	188-197
35018710-3	2022	It is theoretically found that silicon atoms in silicon-rich structures (especially MSi2 and MSi) show a strong site-isolating effect, which can eliminate M-M-M hollow and M-M bridge sites with too strong hydrogen-binding ability and thereby provide great opportunities for the exposure of novel highly active sites (e.g., M-top and Si-related sites).	Hydrogen	205-213	RB binding protein 4, chromatin remodeling factor	Homo sapiens	93-96
35284757-2	2022	The established phase diagram specifies the formation of a complex in a 1:1 stoichiometric ratio which melts congruently at 142  C. The diagram also infers the formation of two eutectics, E1 and E2, on either side of the complex with their respective melting at 118 and 106  C. The stability and novelty of the synthesized complex was confirmed by differential scanning calorimetry, powder X-ray diffraction, and spectroscopic FTIR, 1H, and 13C NMR studies.	Hydrogen	433-435	small nucleolar RNA, H/ACA box 73A	Homo sapiens	188-197
26449341-12	2016	The model indicated that N188 is important for hemichannel docking through formation of hydrogen bonds with the residues R180, T189 and D191 of the opposing hCx46.	Hydrogen	88-96	gap junction protein alpha 3	Homo sapiens	157-162
35130437-5	2022	An in silico analysis of these three inhibitory oligopeptides indicated that they were all bound to the S1 and S2 active pockets of DPP-IV through hydrogen bonds and hydrophobic interactions.	Hydrogen	147-155	dipeptidyl peptidase 4	Homo sapiens	132-138
35077132-5	2022	The erosion rates and layer thicknesses were measured using differential interferometric profiling (DIP), demonstrating a close correlation between the coating thickness and the carbon/hydrogen gas ratio.	Hydrogen	185-193	gastrin	Homo sapiens	194-197
16446799-2	2006	In the cyclic mimetic the intramolecular (1-4) hydrogen bond found in crystalline Leu-enkephalin has been replaced by an ethylene bridge.	Hydrogen	47-55	proenkephalin	Rattus norvegicus	86-96
16435794-0	2006	Collision-induced dissociation of HS-(HCN): unsymmetrical hydrogen bonding in a proton-bound dimer anion.	Hydrogen	58-66	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	38-41
16435794-6	2006	Theoretical calculations show that the proton-transfer potential energy surface has a single minimum and that the hydrogen bonding in the complex is strongly unsymmetrical, with an ion-molecule complex of the form HS(-)..HCN rather than CN(-)..H(2)S or an intermediate structure.	Hydrogen	114-122	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	221-224
26212963-4	2016	Analyses of fluorescence, circular dichroism and Fourier transform infrared spectra indicated that kaempferol bound to alpha-glucosidase with high affinity which was mainly driven by hydrogen bonds and van der Waals forces, and this binding resulted in conformational alteration of alpha-glucosidase.	Hydrogen	183-191	sucrase-isomaltase	Homo sapiens	119-136
35207708-8	2022	The effect of mutations alters the number of hydrogen bonds and hydrophobic interactions in PARK7, as calculated from the Arpeggio server.	Hydrogen	45-53	Parkinsonism associated deglycase	Homo sapiens	92-97
26043781-5	2016	We first did molecular modeling of a homology structure constructed by one mutation at residue 143 from the NMR structure of bovine and cattle PrP(124-227); immediately we found that for BufPrP(C)(124-227), there are five hydrogen bonds (HBs) at Asn143, but at this position, bovine/cattle do not have such HBs.	Hydrogen	222-230	PRP@	Bos taurus	143-146
34990090-5	2022	Moreover, the Gibbs free energy ( GH ) calculation and in situ characterization demonstrate that hydrogen evolution reaction can be effectively suppressed by the Sb layer.	Hydrogen	97-105	gamma-glutamyl hydrolase	Homo sapiens	34-36
16411765-9	2006	In contrast, the Y-family polymerase Dbh was much less sensitive to changes in base pair dimensions and more dependent upon hydrogen bonding between base-paired partners.	Hydrogen	124-132	dopamine beta-hydroxylase	Homo sapiens	37-40
27033079-0	2016	Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry.	Hydrogen	66-74	phosphatase and tensin homolog	Homo sapiens	24-28
17206012-1	2006	An 1H NMR (nuclear magnetic resonance) spectroscopic structural analysis of Cd2+ complexes formed with the pentapeptide phytochelatin, (NH3)+-(gamma-Glu-Cys)2-Gly-COO- (PC2), at a pH of 7.5 showed that the two thiol groups of the Cys residues and either the carbonyl or amide group of the peptide bond between Glu1 and Cys1 act as possible donor groups in the complexes at Cd2+/PC2 ratios up to 0.4.	Hydrogen	3-5	CD2 molecule	Homo sapiens	76-79
16642402-0	2006	New NMR assignment 1H, 13C, and 15N assignment of the second PH domain of human pleckstrin (234-350).	Hydrogen	19-21	pleckstrin	Homo sapiens	80-90
35102188-0	2022	Solid-state synthesis of CdFe2O4 binary catalyst for potential application in renewable hydrogen fuel generation.	Hydrogen	88-96	contactin associated protein 2	Homo sapiens	25-29
35111980-0	2022	Sensitive and resistant of the homologous disulfide-bridged proteins alpha-lactalbumin and lysozyme to attack of hydrogen-atoms, dithiothreitol and trifluoroacetic acid, examined by matrix-assisted laser desorption/ionization mass spectrometry.	Hydrogen	113-121	lactalbumin alpha	Bos taurus	69-86
27094172-8	2016	Docking studies indicated that compound 5c readily binds the active site of human glyoxalase I protein via two strong hydrogen bonds engaging residues of Glu-99 and Lys-156.	Hydrogen	118-126	glyoxalase I	Homo sapiens	82-94
27822364-6	2016	Molecular docking analysis revealed that compound 1 could bind stably to the TRAIL/DR5 complex through hydrogen bonds.	Hydrogen	103-111	TNF receptor superfamily member 10b	Homo sapiens	83-86
26618984-1	2015	This work reports an experimental study of the hydrogen/deuterium exchange in the basic aqueous solutions of trichloroethylene, trans-1,2-dichloroethylene, and cis-1,2-dichloroethylene using (1)H NMR as a monitoring method.	Hydrogen	47-55	suppressor of cytokine signaling 1	Homo sapiens	160-165
25962375-8	2015	Focal adhesion kinase (FAK) activation was reduced in HS group as well as neutrophil infiltration, NOS2 expression and NO content.	Hydrogen	54-56	protein tyrosine kinase 2	Rattus norvegicus	0-21
25962375-8	2015	Focal adhesion kinase (FAK) activation was reduced in HS group as well as neutrophil infiltration, NOS2 expression and NO content.	Hydrogen	54-56	protein tyrosine kinase 2	Rattus norvegicus	23-26
26214274-3	2015	The films were optically clear with resistivity values similar to natural rubber and thermally stable up to 180  C. Addition of glycerol showed to enhance the flexibility of SELP/glycerol films by interacting with SELP molecules through hydrogen bonding, interpenetrating between the polymer chains and granting more conformational freedom.	Hydrogen	237-245	selectin P	Homo sapiens	174-178
26214274-3	2015	The films were optically clear with resistivity values similar to natural rubber and thermally stable up to 180  C. Addition of glycerol showed to enhance the flexibility of SELP/glycerol films by interacting with SELP molecules through hydrogen bonding, interpenetrating between the polymer chains and granting more conformational freedom.	Hydrogen	237-245	selectin P	Homo sapiens	214-218
26602442-5	2015	The first folding step initiates at 320 K upon the hydrophobic collapse of the Trp5 and Trp13 side-chains which stabilizes the concurrent beta-turn formation, whose COi-HNi + 3 hydrogen bond (Asp10   Arg7) appears particularly stable.	Hydrogen	177-185	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	165-168
26399304-5	2015	We attributed this difference to the formation of the PdH-O hydrogen bond with Pd(PPh3)2 which was surprisingly observed in explicit modeling.	Hydrogen	60-68	protein phosphatase 4 catalytic subunit	Homo sapiens	82-86
26171616-4	2015	In this respect, we report herein on the first class of BACE-1/GSK-3beta dual inhibitors based on a 3,4-dihydro-1,3,5-triazin-2(1H)-one skeleton, whose hit compound 1 showed interesting properties in a preliminary investigation.	Hydrogen	128-130	beta-site APP cleaving enzyme 1	Mus musculus	56-62
26171616-4	2015	In this respect, we report herein on the first class of BACE-1/GSK-3beta dual inhibitors based on a 3,4-dihydro-1,3,5-triazin-2(1H)-one skeleton, whose hit compound 1 showed interesting properties in a preliminary investigation.	Hydrogen	128-130	glycogen synthase kinase 3 beta	Mus musculus	63-72
26272610-11	2015	For example the FTIR difference spectra of RasA18T and RanT25A mutants show that spectral differences are mainly due to the hydrogen bond of Thr-25 to the alpha-phosphate in Ran.	Hydrogen	124-132	RAN, member RAS oncogene family	Homo sapiens	55-58
26419974-4	2015	Some test calculations with the B3LYP exchange-correlation functional for N2, F2, CO, NO, HF, and HCN show that total energies within 1.0 to 2.4 mHartree compared to the cc-pV5Z basis sets are attained with our contracted bases with a much smaller number of polarization functions (2p1d and 2d1f for hydrogen and heavier atoms, respectively).	Hydrogen	300-308	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	98-101
26337119-7	2015	Furthermore, the photocatalytic contrast experiments illustrate that the as-synthesized flower-like CdS with L-Histidine is more stable than CdS without L-Histidine in the hydrogen generation.	Hydrogen	172-180	CDP-diacylglycerol synthase 1	Homo sapiens	100-103
26337119-7	2015	Furthermore, the photocatalytic contrast experiments illustrate that the as-synthesized flower-like CdS with L-Histidine is more stable than CdS without L-Histidine in the hydrogen generation.	Hydrogen	172-180	CDP-diacylglycerol synthase 1	Homo sapiens	141-144
28717503-0	2015	Self-assembly of a mesoporous ZnS/mediating interface/CdS heterostructure with enhanced visible-light hydrogen-production activity and excellent stability.	Hydrogen	102-110	CDP-diacylglycerol synthase 1	Homo sapiens	54-57
28717503-4	2015	This excellent H2-production rate corresponded to the highest value among the CdS-based photocatalysts.	Hydrogen	15-17	CDP-diacylglycerol synthase 1	Homo sapiens	78-81
26253656-9	2015	H2 could suppress the release of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1), and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and high-mobility group box 1 protein (HMGB1).	Hydrogen	0-2	vascular cell adhesion molecule 1	Mus musculus	66-99
26253656-9	2015	H2 could suppress the release of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1), and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and high-mobility group box 1 protein (HMGB1).	Hydrogen	0-2	vascular cell adhesion molecule 1	Mus musculus	101-107
25333695-4	2015	Intermolecular hydrogen bonding analysis of the trajectories showed that P218 formed two stable hydrogen bonds with human DHFR (Ile7 and Glu30), wild-type and double-mutant PfDHFR"s (Asp54 and Arg122), while it formed three stable hydrogen bonds with quadruple-mutant PfDHFR (Asp54, Arg59, and Arg122).	Hydrogen	15-23	dihydrofolate reductase	Homo sapiens	122-126
25333695-4	2015	Intermolecular hydrogen bonding analysis of the trajectories showed that P218 formed two stable hydrogen bonds with human DHFR (Ile7 and Glu30), wild-type and double-mutant PfDHFR"s (Asp54 and Arg122), while it formed three stable hydrogen bonds with quadruple-mutant PfDHFR (Asp54, Arg59, and Arg122).	Hydrogen	96-104	dihydrofolate reductase	Homo sapiens	122-126
25333695-4	2015	Intermolecular hydrogen bonding analysis of the trajectories showed that P218 formed two stable hydrogen bonds with human DHFR (Ile7 and Glu30), wild-type and double-mutant PfDHFR"s (Asp54 and Arg122), while it formed three stable hydrogen bonds with quadruple-mutant PfDHFR (Asp54, Arg59, and Arg122).	Hydrogen	96-104	dihydrofolate reductase	Homo sapiens	122-126
26037075-6	2015	Structural modeling studies identified Tyr296 in TLR4 and Ser120 in MD-2 as critical sites for hydrogen bonding with procyanidin B1, similar to the sites occupied by LPS.	Hydrogen	95-103	toll like receptor 4	Homo sapiens	49-53
26134567-2	2015	We utilized fluorescence polarization measurements and hydrogen-deuterium exchange mass spectrometry to define molecular interactions between the specific human isoforms hsp90beta and apo-sGCbeta1.	Hydrogen	55-63	heat shock protein 90 alpha family class B member 1	Homo sapiens	170-179
16402342-0	2006	Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5.	Hydrogen	7-15	kinesin family member 11	Homo sapiens	160-163
26226559-0	2015	Allosteric Breakage of the Hydrogen Bond within the Dual-Histidine Motif in the Active Site of Human Pin1 PPIase.	Hydrogen	27-35	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	101-105
26226559-6	2015	Here, C113A and C113S Pin1 mutants were found to alter the protonation states of H59 according to the respective residue type replaced at C113, and the mutations resulted in disruption of the hydrogen bond within the dual-histidine motif.	Hydrogen	192-200	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	22-26
26250646-6	2015	Comparison simulations on CTB binding to a membrane that is composed of various lipid components demonstrate that several factors are responsible for the nanodomain formation: (a) the negatively charged headgroup of a GM1 receptor is responsible for the multivalent binding; (b) the head groups being full of hydrogen-bonding donors and receptors stabilize the GM1 cluster itself and ensure the toxin binding with high affinity; and	Hydrogen	309-317	chitobiase	Homo sapiens	26-29
16252296-4	2005	Furthermore, the effect of binding on the Syk tSH2 structural dynamics was probed by hydrogen/deuterium exchange and electrospray mass spectrometry (ESI-MS).	Hydrogen	85-93	threonine synthase like 2	Homo sapiens	46-50
26238550-1	2015	Due to their unique catalytic, electronic, and redox processes, Ni5P4 and NiP2 nanoparticles are of interest for a wide-range of applications from the hydrogen evolution reaction to energy storage (batteries); yet synthetic approaches to these materials are limited.	Hydrogen	151-159	BCL2 interacting protein 2	Homo sapiens	74-78
16165354-1	2005	The 7-carbamate groups of geldanamycin and its 17-(2-dimethylaminoethyl)amino-17-demethoxy derivative (17-DMAG) bind the N-terminal domain of Hsp90 by establishing a network of hydrogen bonds which involve four buried water molecules.	Hydrogen	177-185	heat shock protein 90 alpha family class A member 1	Homo sapiens	142-147
26107554-7	2015	The reaction of with PPh3 or PPh2OH affords static [RhHCl{PPh2(o-C6H4CO)}(PPh3)L] () or [RhHCl{PPh2(o-C6H4CO)}(PPh2OH)L] () respectively with trans P-atoms and pyrazoles forming N-HCl hydrogen bonds.	Hydrogen	184-192	protein phosphatase 4 catalytic subunit	Homo sapiens	21-25
16275916-2	2005	The simulated results demonstrate that the overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxyanion hole of BChE in the TS1 structure for (-)-cocaine hydrolysis catalyzed by A199S/S287G/A328W/Y332G BChE should be significantly stronger than that in the TS1 structure for (-)-cocaine hydrolysis catalyzed by the WT BChE and other simulated BChE mutants.	Hydrogen	51-59	butyrylcholinesterase	Homo sapiens	150-154
16275916-2	2005	The simulated results demonstrate that the overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxyanion hole of BChE in the TS1 structure for (-)-cocaine hydrolysis catalyzed by A199S/S287G/A328W/Y332G BChE should be significantly stronger than that in the TS1 structure for (-)-cocaine hydrolysis catalyzed by the WT BChE and other simulated BChE mutants.	Hydrogen	51-59	butyrylcholinesterase	Homo sapiens	240-244
16275916-2	2005	The simulated results demonstrate that the overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxyanion hole of BChE in the TS1 structure for (-)-cocaine hydrolysis catalyzed by A199S/S287G/A328W/Y332G BChE should be significantly stronger than that in the TS1 structure for (-)-cocaine hydrolysis catalyzed by the WT BChE and other simulated BChE mutants.	Hydrogen	51-59	butyrylcholinesterase	Homo sapiens	240-244
16275916-2	2005	The simulated results demonstrate that the overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxyanion hole of BChE in the TS1 structure for (-)-cocaine hydrolysis catalyzed by A199S/S287G/A328W/Y332G BChE should be significantly stronger than that in the TS1 structure for (-)-cocaine hydrolysis catalyzed by the WT BChE and other simulated BChE mutants.	Hydrogen	51-59	butyrylcholinesterase	Homo sapiens	240-244
25740079-3	2015	Both homocysteine levels and endogenous HS(-) production are mainly regulated by two transsulfuration enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Hydrogen	40-45	cystathionine beta-synthase	Mus musculus	111-138
25740079-3	2015	Both homocysteine levels and endogenous HS(-) production are mainly regulated by two transsulfuration enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Hydrogen	40-45	cystathionine beta-synthase	Mus musculus	140-143
25753971-9	2015	Hydrogen bond analysis and binding free energy calculation revealed that SGLT2 binding complex was more stable and favorable than SGLT1 complex, which was highly correlated with the experimental results.	Hydrogen	0-8	solute carrier family 5 member 2	Homo sapiens	73-78
26233134-0	2015	Resonances in rotationally inelastic scattering of NH3 and ND3 with H2.	Hydrogen	68-70	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	59-62
26233134-1	2015	We present theoretical studies on the scattering resonances in rotationally inelastic collisions of NH3 and ND3 molecules with H2 molecules.	Hydrogen	127-129	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	108-111
25953903-3	2015	This substitution also attenuates exchange line broadening in the underlying beta2 and beta3a strands that is centered near a bifurcated main chain hydrogen bond interaction between these two strands.	Hydrogen	148-156	basic helix-loop-helix family member e22	Homo sapiens	87-93
25914328-3	2015	This Co(III) species is doubly reduced to Co(I) and exhibits H(+) reduction activity in the presence of weak acids in MeCN and evolves H2 upon protonation suggesting that the ligand design increases catalyst effectiveness.	Hydrogen	135-137	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	42-47
25938660-3	2015	To distinguish between local displacement versus global unfolding mechanisms for complex disassembly, we carried out hydrogen/deuterium exchange during Saccharomyces cerevisiae Vps4 disassembly of a chimeric Vps24-2 ESCRT-III filament.	Hydrogen	117-125	AAA family ATPase VPS4	Saccharomyces cerevisiae S288C	177-181
25913814-0	2015	Spectacular photocatalytic hydrogen evolution using metal-phosphide/CdS hybrid catalysts under sunlight irradiation.	Hydrogen	27-35	CDP-diacylglycerol synthase 1	Homo sapiens	68-71
25913814-1	2015	A highly efficient and robust heterogeneous photocatalytic hydrogen evolution system was established for the first time by using the CoP/CdS hybrid catalyst in water under solar irradiation.	Hydrogen	59-67	caspase recruitment domain family member 16	Homo sapiens	133-136
25913814-1	2015	A highly efficient and robust heterogeneous photocatalytic hydrogen evolution system was established for the first time by using the CoP/CdS hybrid catalyst in water under solar irradiation.	Hydrogen	59-67	CDP-diacylglycerol synthase 1	Homo sapiens	137-140
25913814-2	2015	The H2-production rate can reach up to 254,000 mumol h(-1) g(-1) during 4.5 h of sunlight irradiation, which is one of the highest values ever reported on CdS photocatalytic systems in the literature.	Hydrogen	4-6	CDP-diacylglycerol synthase 1	Homo sapiens	155-158
25907383-2	2015	Our calculations show that when the two reactants approach each other, three prereaction complexes, RC1, RC2, and RC3, can be formed through van der Waals force or hydrogen bonding.	Hydrogen	164-172	chromobox 8	Homo sapiens	100-103
25672503-3	2015	In contrast to the other LHC proteins and the majority of photosynthesis proteins, the Chlamydomonas reinhardtii photosystem II-associated LHC protein, LHCBM9, was recently reported to be up-regulated under sulphur deprivation conditions, which also induce hydrogen production.	Hydrogen	257-265	uncharacterized protein	Chlamydomonas reinhardtii	152-158
25672503-7	2015	The study of LHCBM9 is of biological and biotechnological importance, as its expression is linked to photobiological hydrogen production, theoretically the most efficient process for biofuel production, while the simplicity of using an S-deprivation trigger enables the development of a novel C. reinhardtii-inducible promoter system based on LHCBM9.	Hydrogen	117-125	uncharacterized protein	Chlamydomonas reinhardtii	13-19
25804803-12	2015	From this Rh(II)(H) species, the heterolytic and homolytic pathways are both thermodynamically favourable to produce H2 confirming that Rh(II)(H) is as reactive as Rh(III)(H) towards the production of H2.	Hydrogen	117-119	Rh blood group D antigen	Homo sapiens	10-16
25804803-12	2015	From this Rh(II)(H) species, the heterolytic and homolytic pathways are both thermodynamically favourable to produce H2 confirming that Rh(II)(H) is as reactive as Rh(III)(H) towards the production of H2.	Hydrogen	117-119	Rh blood group D antigen	Homo sapiens	136-142
25804803-12	2015	From this Rh(II)(H) species, the heterolytic and homolytic pathways are both thermodynamically favourable to produce H2 confirming that Rh(II)(H) is as reactive as Rh(III)(H) towards the production of H2.	Hydrogen	201-203	Rh blood group D antigen	Homo sapiens	10-16
25804803-12	2015	From this Rh(II)(H) species, the heterolytic and homolytic pathways are both thermodynamically favourable to produce H2 confirming that Rh(II)(H) is as reactive as Rh(III)(H) towards the production of H2.	Hydrogen	201-203	Rh blood group D antigen	Homo sapiens	136-142
25995909-2	2015	In the crystal, an O-H O hydrogen bond between the hy-droxy groups at the C-3 and C-2 positions connects homochiral mol-ecules into a column along the b axis.	Hydrogen	25-33	complement C2	Homo sapiens	82-85
25836281-7	2015	Additionally, there are hydrogen-bonding interactions involving the solvent water molecules and the arsonate and amine groups of the Hapa(-) ligands, and weak pi-pi stacking interactions within the [Ag(Hapa)(PPh3)]n layer.	Hydrogen	24-32	protein phosphatase 4 catalytic subunit	Homo sapiens	208-212
25501280-8	2015	Therefore, LASS2/TMSG1 may inhibit growth and invasion of breast cancer cell in vitro through decreasing V-ATPase activity and extracellular hydrogen ion concentration and inactivating secreted MMP-2.	Hydrogen	141-149	ceramide synthase 2	Homo sapiens	11-16
25501280-8	2015	Therefore, LASS2/TMSG1 may inhibit growth and invasion of breast cancer cell in vitro through decreasing V-ATPase activity and extracellular hydrogen ion concentration and inactivating secreted MMP-2.	Hydrogen	141-149	ceramide synthase 2	Homo sapiens	17-22
25679519-7	2015	Both Pd nanowires and Pd@Pt nanowires show a prompt and reversible increase in resistance upon exposure to H2 in air, caused by the conversion of Pd to more resistive PdHx.	Hydrogen	107-109	pyruvate dehydrogenase complex component X	Homo sapiens	167-171
25658952-0	2015	C60-decorated CdS/TiO2 mesoporous architectures with enhanced photostability and photocatalytic activity for H2 evolution.	Hydrogen	109-111	CDP-diacylglycerol synthase 1	Homo sapiens	14-17
21783618-9	2005	Exposure to DBT for 1h followed by either a 24 or 48h period in DBT-free media, decreased levels of granzyme B and perforin.	Hydrogen	20-22	granzyme B	Homo sapiens	100-110
25916785-12	2015	CONCLUSION: Hydrogen-rich saline can attenuate global cerebral I/R injure through inhibiting JNK, reducing the expression of FOXO3a.	Hydrogen	12-20	mitogen-activated protein kinase 8	Rattus norvegicus	93-96
24300376-1	2015	An infrared spectroscopic and MP2/6-311++G(2d,2p) study of hydrogen bonded complexes of formaldoxime with ammonia and hydrogen chloride trapped in solid argon matrices is reported.	Hydrogen	59-67	tryptase pseudogene 1	Homo sapiens	30-33
16212380-3	2005	Crystallographic results show binding of the acyclic quasiplanar water tetramer [H4L(H2O)4](I)4.2.57H2O (1) in a tetraprotonated cryptand L having an iodide counteranion, where two water molecules reside inside the two tren-based cavity, bridged by a third water molecule, and a fourth external water molecule is hydrogen bonded to the bridged water molecule.	Hydrogen	313-321	H4 clustered histone 7	Homo sapiens	81-84
16193111-1	2005	A neutral electrochemical chemosensor based on TTF exhibited high selectivity for H2PO4- over a wide range of anions and the significant C-H...O hydrogen bonding between C=C-H of the TTF unit and H2PO4- played an important role in regulating the selectivity.	Hydrogen	145-153	ras homolog family member H	Homo sapiens	183-186
25541201-4	2015	Molecular docking showed that compounds 7h and 12c were nicely bound to hMAO-A via two hydrogen bonds (SER209, GLU216), one Pi-Pi interaction and three hydrogen bonds (SER209, GLU216, TYR69), one Sigma-Pi interaction, respectively.	Hydrogen	87-95	monoamine oxidase A	Homo sapiens	72-78
16277308-4	2005	Enthalpies of hydrogen bonding to a reference hydrogen-bond acceptor, 4-fluorophenol, have been determined in CCl4 and/or C2Cl4 for ammonia and 68 primary, secondary, and tertiary amines.	Hydrogen	14-22	C-C motif chemokine ligand 4	Homo sapiens	110-114
25541201-4	2015	Molecular docking showed that compounds 7h and 12c were nicely bound to hMAO-A via two hydrogen bonds (SER209, GLU216), one Pi-Pi interaction and three hydrogen bonds (SER209, GLU216, TYR69), one Sigma-Pi interaction, respectively.	Hydrogen	152-160	monoamine oxidase A	Homo sapiens	72-78
25544680-9	2015	Reference tri-peptide atomic co-ordinate sets including hydrogen atoms are made freely available.	Hydrogen	56-64	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	10-13
16149782-1	2005	[structure: see text] 1H NMR spectra of aldohexopyranosyl rings containing 13C-enrichment at either C1 or C3 reveal the presence of long-range 4J(C1,H6R/S) and 4J(C3,H6R/S) whose magnitudes depend mainly on the O5-C5-C6-O6 torsion angle.	Hydrogen	22-24	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	146-152
16129837-2	2005	In contrast, gustatory detection of salty and sour tastes may involve direct gating of sodium channels of the DEG/ENaC family by sodium and hydrogen ions, respectively.	Hydrogen	140-148	deg	Drosophila melanogaster	110-113
15836438-4	2005	21, 71-76], was solved by 1H-NMR and its structure was modelled in its complex with gp120.	Hydrogen	26-28	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	84-89
15927620-2	2005	The resulting CdS nanoparticles-aluminosilicate composites (ASCdS) were used as photocatalysts for H2 generation from 2-propanol aqueous solution.	Hydrogen	99-101	CDP-diacylglycerol synthase 1	Homo sapiens	14-17
16006062-6	2005	Predicted hydrogen bond interactions involving Asp155 play an important role in the enzymatic properties of this glutathione S-transferase.	Hydrogen	10-18	glutathione S-transferase	Paraburkholderia xenovorans LB400	113-138
15924294-0	2005	1H NMR study of the conformation and absolute stereochemistry of two spirocyclic NK-1 antagonists.	Hydrogen	0-2	tachykinin receptor 1	Homo sapiens	81-85
15908222-2	2005	In order to identify the small fragment interacting with residues in the S1" pocket of MMP-1 through hydrogen bonds, we performed in silico screening using the LUDI program.	Hydrogen	101-109	matrix metallopeptidase 1	Homo sapiens	87-92
16132820-0	2005	Water-protein hydrogen exchange in the micro-crystalline protein crh as observed by solid state NMR spectroscopy.	Hydrogen	14-22	corticotropin releasing hormone	Homo sapiens	65-68
16132820-1	2005	We report site-resolved observation of hydrogen exchange in the micro-crystalline protein Crh.	Hydrogen	39-47	corticotropin releasing hormone	Homo sapiens	90-93
15970795-9	2005	Increased enzyme lability of CYP2C9.11 may be related to improper folding due to the disruption of conserved salt-bridge and hydrogen bonding contacts in the loop region between the J and J" helices of the protein.	Hydrogen	125-133	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	29-35
15912548-0	2005	Hydrogen-bonded CdS nanoparticle assemblies on electrodes for photoelectrochemical applications.	Hydrogen	0-8	CDP-diacylglycerol synthase 1	Homo sapiens	16-19
15952772-9	2005	From H(2)O/(2)H(2)O exchange experiments, we concluded that the impact of Zn(2+) and Cd(2+) binding on the oxidation kinetics of ferrocytochrome c by H(2)O(2) is associated to the perturbation of a hydrogen-bonding network involving His 33 that is sensitive to the redox state of cytochrome c.	Hydrogen	198-206	cytochrome c, somatic	Equus caballus	134-146
15896958-1	2005	Conversion of the proline-derived cyanamide lead to an acyclic cyanamide capable of forming an additional hydrogen bond with cathepsin K resulted in a large increase in inhibitory activity.	Hydrogen	106-114	cathepsin K	Rattus norvegicus	125-136
15934751-4	2005	The three Glu268, Glu369, and Tyr494 residues are suggested to play an important role in the substrate binding at the active site of DBM to enable the stereospecific hydrogen-atom abstraction.	Hydrogen	166-174	dopamine beta-hydroxylase	Rattus norvegicus	133-136
15924417-6	2005	The analysis of N-D and O-D stretching vibrations in D(2)O revealed that the hydrogen bond of the Schiff base is weaker in retinochrome than in bovine rhodopsin and bacteriorhodopsin, while retinochrome has a water molecule under strongly hydrogen-bonded conditions (O-D stretch at 2334 cm(-)(1)).	Hydrogen	77-85	rhodopsin	Bos taurus	151-160
25155442-6	2015	Results show that PRX-102 has prolonged in-vitro stability in plasma, after 1h incubation it retains 30% activity compared with complete inactivation of the commercial enzymes.	Hydrogen	76-78	periaxin	Homo sapiens	18-21
25537611-4	2015	On evaluating their photocatalytic activity for hydrogen evolution, the oligomers were found to be the most active species, having up to twice the activity of the monomer/oligomer mixture of the as-synthesized material, which in turn has 3 times the activity of the polymer melon, the literature benchmark.	Hydrogen	48-56	hyaluronan synthase 3	Homo sapiens	234-239
25537000-2	2015	Starting from a recently solved crystal structure of ATP-like kinesin-tubulin complex by the Knossow lab, we have used flexible fitting of cryo-electron-microscopy maps to construct new structural models of the kinesin-tubulin complex in APO and ATP state, and then conducted extensive MD simulations (total 400 ns for each state), followed by flexibility analysis, principal component analysis, hydrogen bond analysis, and binding free energy analysis.	Hydrogen	396-404	aminopeptidase O (putative)	Homo sapiens	238-241
25475482-2	2015	The structure of 11.1 mol% i-PA + H2 hydrate was identified to be hexagonal (space group P63/mmc) with a few unindexed diffraction peaks, while 5.6 mol% i-PA + H2 hydrate had a cubic structure (space group Fd3 m).	Hydrogen	34-36	tumor protein p63	Homo sapiens	89-92
25561553-5	2015	In addition to many conserved contacts, FcgammaRI forms additional hydrogen bonds and salt bridges with the lower hinge region of Fc.	Hydrogen	67-75	Fc gamma receptor Ia	Homo sapiens	40-49
25513719-7	2015	From molecular dynamics simulations of IKKbeta-inhibitor complexes, we also found that complete dynamic stability of the bidentate hydrogen bond with Cys99 was required for low nanomolar-level inhibitory activity.	Hydrogen	131-139	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	39-46
25878401-4	2015	Results showed that hydrogen-rich saline attenuated the following: (1) serum Cr and BUN, (2) pancreatic and renal pathological injuries, (3) renal MDA, (4) renal MPO, (5) serum IL-1beta, IL-6, and renal TNF-alpha, HMGB1, and (6) tyrosine nitration, IkappaB degradation, and NF-kappaB activation in renal tissues.	Hydrogen	20-28	myeloperoxidase	Rattus norvegicus	162-165
25823787-4	2015	RESULTS: CYP2C9*2 and CYP2C9*3 variants exhibited high warfarin/7-hydroxywarfarin (multiple linear regression model), dose-dependent disruption of hydrogen bonds with warfarin, dose-dependent increase in the distance between C7 of S-warfarin and Fe-O of CYP2C9, dose-dependent decrease in the glide scores (in silico).	Hydrogen	147-155	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	9-15
25823787-4	2015	RESULTS: CYP2C9*2 and CYP2C9*3 variants exhibited high warfarin/7-hydroxywarfarin (multiple linear regression model), dose-dependent disruption of hydrogen bonds with warfarin, dose-dependent increase in the distance between C7 of S-warfarin and Fe-O of CYP2C9, dose-dependent decrease in the glide scores (in silico).	Hydrogen	147-155	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	22-28
25823787-4	2015	RESULTS: CYP2C9*2 and CYP2C9*3 variants exhibited high warfarin/7-hydroxywarfarin (multiple linear regression model), dose-dependent disruption of hydrogen bonds with warfarin, dose-dependent increase in the distance between C7 of S-warfarin and Fe-O of CYP2C9, dose-dependent decrease in the glide scores (in silico).	Hydrogen	147-155	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	22-28
25823787-5	2015	CONCLUSION: CYP2C9*2 and CYP2C9*3 variants result in disruption of hydrogen bonding interactions with warfarin and longer distance between C7 and Fe-O thus impairing warfarin 7-hydroxylation due to lower binding affinity of warfarin.	Hydrogen	67-75	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	12-18
25823787-5	2015	CONCLUSION: CYP2C9*2 and CYP2C9*3 variants result in disruption of hydrogen bonding interactions with warfarin and longer distance between C7 and Fe-O thus impairing warfarin 7-hydroxylation due to lower binding affinity of warfarin.	Hydrogen	67-75	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	25-31
25412145-3	2014	The native IL-1beta contains a hydrogen bond between the Y157 side-chain OetaH and I133 backbone CO, whereby the substitution from Tyr to Phe abolishes the connection and the mutant without the hydrogen bond is more stable.	Hydrogen	31-39	interleukin 1, beta	Gallus gallus	11-19
25412145-3	2014	The native IL-1beta contains a hydrogen bond between the Y157 side-chain OetaH and I133 backbone CO, whereby the substitution from Tyr to Phe abolishes the connection and the mutant without the hydrogen bond is more stable.	Hydrogen	194-202	interleukin 1, beta	Gallus gallus	11-19
25409346-6	2014	PEG-based stabilization in WW is associated with enhanced resistance to proteolysis, is entropic in origin, and likely involves disruption by PEG of the network of hydrogen-bound solvent molecules that surround the protein.	Hydrogen	164-172	progestagen associated endometrial protein	Homo sapiens	0-3
15993126-4	2005	MrHSP90 and MrHSP70 were highly upregulated in post-diapausing pupae exposed to 40 degrees C for 1h, while MrHSC70 was only slightly induced by heat shock.	Hydrogen	97-99	heat shock 70 kDa protein cognate 4	Megachile rotundata	12-19
25409346-6	2014	PEG-based stabilization in WW is associated with enhanced resistance to proteolysis, is entropic in origin, and likely involves disruption by PEG of the network of hydrogen-bound solvent molecules that surround the protein.	Hydrogen	164-172	progestagen associated endometrial protein	Homo sapiens	142-145
25325244-6	2014	Reaction is found to proceed via initial hydrogen abstraction from the gamma-methylene group and from the beta-hydroxyl group, with both reaction channels eventually forming isobaric product ions due to loss of either  OH + HCHO or  OH + CO2.	Hydrogen	41-49	complement C2	Homo sapiens	238-241
15713410-4	2005	The pyrazole ring forms hydrogen bonds to the backbone carbonyl of Gly97, the hydroxyl group of Thr184 and to a water molecule, which is present in all of the published HSP90 structures.	Hydrogen	24-32	heat shock protein 90 alpha family class A member 1	Homo sapiens	169-174
25459908-9	2014	Feeding LS versus HS resulted in an increase in the ratio of bovine somatotropin to insulin.	Hydrogen	18-20	somatotropin	Bos taurus	68-80
16787306-8	2005	The results support the hypothesis that residues which put into the cavity and contribute to hydrogen bonding forces are involved to a control of the transport of hydrated cations through the P2X2 channel.	Hydrogen	93-101	purinergic receptor P2X 2	Homo sapiens	192-196
25459908-9	2014	Feeding LS versus HS resulted in an increase in the ratio of bovine somatotropin to insulin.	Hydrogen	18-20	insulin	Bos taurus	84-91
25429931-6	2014	For complete basis set (CBS) predictions of hydrogen transfer reaction energies, the OMP2.5 method exhibits a substantially better performance than MP2.5, providing a mean absolute error of 1.1 kcal mol(-1), which is more than 10 times lower than that of MP2.5 (11.8 kcal mol(-1)), and comparing to MP2 (14.6 kcal mol(-1)) there is a more than 12-fold reduction in errors.	Hydrogen	44-52	tryptase pseudogene 1	Homo sapiens	86-89
15709775-3	2005	Three products were observed from the reactions catalyzed by TIM: GAP from isomerization with intramolecular transfer of hydrogen (18% of the enzymatic products), d-GAP from isomerization with incorporation of deuterium from D(2)O into C-2 of GAP (43% of the enzymatic products), and [1(R)-(2)H]-DHAP (d-DHAP) from incorporation of deuterium from D(2)O into C-1 of DHAP (40% of the enzymatic products).	Hydrogen	121-129	triosephosphate isomerase	Oryctolagus cuniculus	61-64
25332402-1	2014	G-rich nucleic acids can form non-canonical G-quadruplex structures (G4s) in which four guanines fold in a planar arrangement through Hoogsteen hydrogen bonds.	Hydrogen	144-152	arylsulfatase B	Homo sapiens	69-72
15704907-1	2005	Tri-(2-alkoxy-5-ureido-phenyl)methanes represent a novel self-complementary motif forming hydrogen bonded homo- and heterodimers in nonpolar, aprotic solvents as evidenced by 1H NMR and ESI-mass spectra and by the formation of heterodimers.	Hydrogen	90-98	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	0-3
15704907-1	2005	Tri-(2-alkoxy-5-ureido-phenyl)methanes represent a novel self-complementary motif forming hydrogen bonded homo- and heterodimers in nonpolar, aprotic solvents as evidenced by 1H NMR and ESI-mass spectra and by the formation of heterodimers.	Hydrogen	175-177	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	0-3
25256626-3	2014	Highly selective 1,2-migration referring to the two substituents R(3) and R(4) (R(4) =H, alkyl, and aryl group) was observed: (1) In the presence of both H and alkyl groups, 1,2-hydrogen migration is exclusive; (2) in the presence of a methyl group (R(3) ), propyl, isopropyl, 4-methylphenyl, and 4-chlorophenyl groups (R(4) ) migrate exclusively.	Hydrogen	178-186	CD1d molecule	Homo sapiens	236-254
15663944-4	2005	We have used a number of 1H-15N nuclear magnetic resonance (NMR) experiments in conjunction with site-directed mutagenesis to study the acid-unfolded state of beta2m.	Hydrogen	25-27	beta-2-microglobulin	Homo sapiens	159-165
24819195-1	2014	Studies concerning interactions between anti-beta2-glycoprotein I antibodies (anti-beta2GPI) and beta2-glycoprotein I (beta2GPI) suggest relevance of charge interactions and hydrogen bonds.	Hydrogen	174-182	apolipoprotein H	Homo sapiens	45-65
16851119-4	2005	The results of this investigation suggest that initial step in the HCN + NO(2) reaction over these catalysts is the hydrogen abstraction from HCN, and the formation of ionic CN- and NC- species.	Hydrogen	116-124	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	67-70
16851119-4	2005	The results of this investigation suggest that initial step in the HCN + NO(2) reaction over these catalysts is the hydrogen abstraction from HCN, and the formation of ionic CN- and NC- species.	Hydrogen	116-124	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	142-145
24819195-1	2014	Studies concerning interactions between anti-beta2-glycoprotein I antibodies (anti-beta2GPI) and beta2-glycoprotein I (beta2GPI) suggest relevance of charge interactions and hydrogen bonds.	Hydrogen	174-182	apolipoprotein H	Homo sapiens	83-91
24819195-1	2014	Studies concerning interactions between anti-beta2-glycoprotein I antibodies (anti-beta2GPI) and beta2-glycoprotein I (beta2GPI) suggest relevance of charge interactions and hydrogen bonds.	Hydrogen	174-182	apolipoprotein H	Homo sapiens	97-117
24819195-1	2014	Studies concerning interactions between anti-beta2-glycoprotein I antibodies (anti-beta2GPI) and beta2-glycoprotein I (beta2GPI) suggest relevance of charge interactions and hydrogen bonds.	Hydrogen	174-182	apolipoprotein H	Homo sapiens	119-127
15455468-3	2005	In this study, the global high-concentration metabolite composition of CSF has been correlated with patient outcome after subarachnoid haemorrhage using multivariate statistics and 1H NMR spectroscopy.	Hydrogen	181-183	colony stimulating factor 2	Homo sapiens	71-74
15516695-8	2005	Computer modeling of the HO-1/CPR complex showed that the guanidino group of Arg(185) is located within the hydrogen bonding distance of 2"-phosphate of NADPH, suggesting that Arg(185) contributes to the binding to CPR through an electrostatic interaction with the phosphate group.	Hydrogen	108-116	heme oxygenase 1	Homo sapiens	25-29
24819195-8	2014	The amino acid composition of selected peptides confirmed the importance of hydrogen bonds and charge interactions in the binding of anti-beta2GPI to the antigen.	Hydrogen	76-84	apolipoprotein H	Homo sapiens	138-146
24819195-9	2014	Epitopes recognized by high avidity anti-beta2GPI predominately contain hydrogen bond forming side chains, while in low avidity anti-beta2GPI epitope the charged side chains prevail.	Hydrogen	72-80	apolipoprotein H	Homo sapiens	41-49
25338820-0	2014	Competition between pi-hole interaction and hydrogen bond in the complexes of F2XO (X = C and Si) and HCN.	Hydrogen	44-52	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	102-105
16059664-5	2005	On the other hand, COX-1-selective oxicam inhibitors gain extra stabilization energy with the change of residue 523 from valine to isoleucine because of the formations of new hydrogen bonds in the enzyme-inhibitor complexes.	Hydrogen	175-183	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	19-24
25338820-2	2014	F2XO has a dual role of a Lewis acid and base with the pi-hole on the X atom and the O atom to participate in the pi-hole interaction and hydrogen bond with HCN, respectively.	Hydrogen	138-146	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	157-160
25340302-1	2014	Formation of mixed-ligand Pd2+ complexes between canonical nucleoside 5"-monophosphates and five metal-ion-binding nucleoside analogs has been studied by 1H-NMR spectroscopy to test the ability of these nucleoside surrogates to discriminate between unmodified nucleobases by Pd2+-mediated base pairing.	Hydrogen	154-156	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	26-29
15598500-5	2005	Special emphasis is given to the long-lived HNO adduct of myoglobin, including its synthesis by various routes and characterization by 1H NMR, resonance Raman and X-ray absorption spectroscopy.	Hydrogen	135-137	myoglobin	Homo sapiens	58-67
23765287-0	2014	1H, 13C and 15N NMR assignments of a Drosophila Hedgehog autoprocessing domain.	Hydrogen	0-2	hedgehog	Drosophila melanogaster	48-56
16180417-4	2005	The observed average specific hydrogen production rate was 276 mLH2/gVSS d, which was 40% higher than that of the one acclimated with 3 kgCOD/m3 d. Based on denaturing gradient gel electrophoresis profiles, significant microbial population shifts took place at the first 15 days, but a longer period up to 30 days was required to establish a microbial community with stable metabolic activity.	Hydrogen	30-38	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	63-67
23832675-0	2014	1H, 13C and 15N resonance assignments of Rpn9, a regulatory subunit of 26S proteasome from Saccharomyces cerevisiae.	Hydrogen	0-2	proteasome regulatory particle lid subunit RPN9	Saccharomyces cerevisiae S288C	41-45
30011633-6	2014	Isothermal titration calorimetry (ITC) analysis implied that EGCG was spontaneously bound to LF by a two-stage mechanism, about 31 EGCG molecules were integrated with 1 molecule LF and hydrogen bonds were always involved in the assembly process.	Hydrogen	185-193	lactotransferrin	Bos taurus	93-95
25132299-0	2014	Caution on the use of NBS 30 biotite for hydrogen-isotope measurements with on-line high-temperature conversion systems.	Hydrogen	41-49	nibrin	Homo sapiens	22-25
25124830-2	2014	The Mnx Co3 x O4 delta materials showed ultrahigh oxygen evolution activity and strong durability in alkaline solutions, and are capable of delivering a current density of 10 mA cm(-2) at 1.58 V versus the reversible hydrogen electrode in 0.1 M KOH solution, which is superior in comparison to IrO2 catalysts under identical experimental conditions, and comparable to the most active noble-metal and transition-metal oxygen evolution electrocatalysts reported so far.	Hydrogen	217-225	keratin 86	Homo sapiens	4-7
25049220-3	2014	By the use of advanced hydrogen/deuterium-exchange mass spectrometry (HDX-MS) it is shown that the serpin plasminogen activator inhibitor 1 (PAI-1) transiently unfolds under native condition, on a second-to-minute time scale.	Hydrogen	23-31	serpin family E member 1	Homo sapiens	141-146
2489100-4	1989	Temperature dependence of NH proton chemical shift and NOE experiments showed that Boc-Asn-Aib-Thr-Aib-OMe has a tendency to form a beta-turn structure with a hydrogen bond involving Thr and Aib4 NH groups.	Hydrogen	159-167	ANIB1	Homo sapiens	91-94
2489100-4	1989	Temperature dependence of NH proton chemical shift and NOE experiments showed that Boc-Asn-Aib-Thr-Aib-OMe has a tendency to form a beta-turn structure with a hydrogen bond involving Thr and Aib4 NH groups.	Hydrogen	159-167	ANIB1	Homo sapiens	99-102
2692710-0	1989	Structural and dynamic differences between normal and transforming N-ras gene products: a 31P and isotope-edited 1H NMR study.	Hydrogen	113-115	NRAS proto-oncogene, GTPase	Homo sapiens	67-72
25137532-7	2014	H2 evolution with Rh2 catalysts typically proceeds via two-electron photoreduction, protonation to afford Rh hydrides, and photochemical H2 evolution.	Hydrogen	0-2	Rh associated glycoprotein	Homo sapiens	18-21
2776191-8	1989	Changes in internal hydrogen activity, [H+]i, induced by current flow from the internal Pt wire limited the extent to which valid measurements of [Ca2+]i could be made.	Hydrogen	20-28	carbonic anhydrase 2	Homo sapiens	147-150
25137532-7	2014	H2 evolution with Rh2 catalysts typically proceeds via two-electron photoreduction, protonation to afford Rh hydrides, and photochemical H2 evolution.	Hydrogen	137-139	Rh associated glycoprotein	Homo sapiens	18-21
25137532-10	2014	H2 evolution from both HCl and HBr proceeds with a halide-bridged Rh2 hydride photoresting state.	Hydrogen	0-2	Rh associated glycoprotein	Homo sapiens	66-69
25092049-2	2014	Computational results showed that BSA hydrophobically binds to FLR which is energetically favorable and leads to the spontaneous formation of the stable nanobiocomposite and also showed that interaction of NLT with BSA is mainly driven by hydrogen bonding and hydrophobic interactions.	Hydrogen	239-247	biliverdin reductase B	Homo sapiens	63-66
2517949-1	1989	Transformation of murine NIH3T3 fibroblasts with retroviral vectors carrying the mos, myc and the Ha-ras oncogene, respectively, was associated with a strong reduction of H2 antigen expression in the cell membrane.	Hydrogen	171-173	Harvey rat sarcoma virus oncogene	Mus musculus	98-104
24196871-0	2014	Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells.	Hydrogen	15-23	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	43-48
2547890-0	1989	Detection of vesicular lipoproteins in lecithin:cholesterol acyltransferase-deficient plasma by 1H-NMR spectroscopy.	Hydrogen	96-98	lecithin-cholesterol acyltransferase	Homo sapiens	39-75
24196871-4	2014	We found that treatment with H2 prevented RANKL-induced osteoclast differentiation in RAW264.7 cells and BMMs.	Hydrogen	29-31	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	42-47
24196871-5	2014	Treatment with H2 inhibits the ability to form resorption pits of BMMs stimulated by RANKL.	Hydrogen	15-17	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	85-90
24196871-8	2014	In addition, treatment with H2 suppressed RANKL-induced expression of nuclear factor of activated T cells c1 and c-Fos.	Hydrogen	28-30	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	42-47
2505062-1	1989	It has been shown by 1H-NMR, circular dichroism, fluorescence and viscometry techniques that equilibrium unfolding of carbonic anhydrase B (a one-domain globular protein) in urea guanidine hydrochloride consists of two sequential stages.	Hydrogen	21-23	carbonic anhydrase 2	Homo sapiens	118-138
24196871-8	2014	In addition, treatment with H2 suppressed RANKL-induced expression of nuclear factor of activated T cells c1 and c-Fos.	Hydrogen	28-30	FBJ osteosarcoma oncogene	Mus musculus	113-118
24196871-9	2014	Furthermore, treatment with H2 suppressed NF-kappaB activation and reduced phosphorylation of p38, extracellular signal-regulated kinase, c-Jun-N-terminal kinase, and protein kinases B (AKT) stimulated with RANKL.	Hydrogen	28-30	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	207-212
24196871-10	2014	In conclusion, hydrogen molecules prevented RANKL-induced osteoclast differentiation associated with inhibition of reactive oxygen species formation and inactivation of NF-kappaB, mitogen-activated protein kinase and AKT pathways.	Hydrogen	15-23	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	44-49
2696784-6	1989	2) The two different hydrogen bonding schemes of inosine-adenine base-pairing, anti/anti and anti/syn forms, are adopted in B-DNA structure.	Hydrogen	21-29	synemin	Homo sapiens	98-101
24961169-0	2014	Construction of two-dimensional MoS2/CdS p-n nanohybrids for highly efficient photocatalytic hydrogen evolution.	Hydrogen	93-101	CDP-diacylglycerol synthase 1	Homo sapiens	37-40
2493647-1	1989	We have recently shown that the synthesis of cyclooxygenase [also called prostaglandin (PG) synthase or PG endoperoxide synthase; 8,11,14-icosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.1] in human dermal fibroblasts is markedly stimulated by the cytokine interleukin 1 (IL-1).	Hydrogen	154-162	thioredoxin reductase 1	Homo sapiens	176-190
2470438-6	1989	There are indications that the two last turns are stabilized by a hydrogen bond between the syn carboxamide proton and the pGlu ring carbonyl.	Hydrogen	66-74	synemin	Homo sapiens	92-95
24961169-2	2014	Due to the unique p-n junction heterostructure, large specific surface area, and decreased band gap, MoS2/CdS nanohybrids manifested a superior H2 -production rate of ~137 mumol h(-1) under visible-light irradiation and an apparent quantum yield of 10.5% at 450 nm.	Hydrogen	144-146	CDP-diacylglycerol synthase 1	Homo sapiens	106-109
24914947-2	2014	To probe these interactions, we substituted the noncanonical amino acid p-aminophenylalanine (pAF) for the active site tyrosine in the lysine methyltransferase SET7/9, which forms multiple CH   O hydrogen bonds to AdoMet and is invariant in SET domain enzymes.	Hydrogen	196-204	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	160-166
2517029-8	1989	(3) We propose that any additional hydrogen-bond donor present between C1 and C15 could cause a hydrogen-bond mispairing and therefore a decreased activity.	Hydrogen	35-43	placenta associated 8	Homo sapiens	78-81
2517029-8	1989	(3) We propose that any additional hydrogen-bond donor present between C1 and C15 could cause a hydrogen-bond mispairing and therefore a decreased activity.	Hydrogen	96-104	placenta associated 8	Homo sapiens	78-81
24914947-3	2014	Using quantum chemistry calculations to predict the mutation"s effects, coupled with biochemical and structural studies, we observed that pAF forms a strong CH   N hydrogen bond to AdoMet that is offset by an energetically unfavorable amine group rotamer within the SET7/9 active site that hinders AdoMet binding and activity.	Hydrogen	164-172	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	266-272
24949823-0	2014	Enhanced photocatalytic hydrogen production activity via dual modification of MOF and reduced graphene oxide on CdS.	Hydrogen	24-32	CDP-diacylglycerol synthase 1	Homo sapiens	112-115
3246478-1	1988	In the crystal, the backbone of Boc-(Aib-Val-Ala-Leu)2-Aib-OMe adopts a helical form with four alpha-type hydrogen bonds in the middle, flanked by 3(10)-type hydrogen bonds at either end.	Hydrogen	106-114	BOC cell adhesion associated, oncogene regulated	Homo sapiens	32-35
3246478-1	1988	In the crystal, the backbone of Boc-(Aib-Val-Ala-Leu)2-Aib-OMe adopts a helical form with four alpha-type hydrogen bonds in the middle, flanked by 3(10)-type hydrogen bonds at either end.	Hydrogen	106-114	ANIB1	Homo sapiens	37-40
24949823-1	2014	A Ternary composite UiO-66/CdS/1% reduced graphene oxide (RGO) was successfully prepared, with a photocatalytic hydrogen evolution rate 13.8 times as high as that of pure commercial CdS.	Hydrogen	112-120	CDP-diacylglycerol synthase 1	Homo sapiens	27-32
9945720-0	1988	Spin-polarized hydrogen in high magnetic fields.	Hydrogen	15-23	spindlin 1	Homo sapiens	0-4
24949823-1	2014	A Ternary composite UiO-66/CdS/1% reduced graphene oxide (RGO) was successfully prepared, with a photocatalytic hydrogen evolution rate 13.8 times as high as that of pure commercial CdS.	Hydrogen	112-120	CDP-diacylglycerol synthase 1	Homo sapiens	27-30
24921685-2	2014	A simple and universal method for the estimation of the intramolecular hydrogen bond (HB) energy (E(HB)) in hydroxycarbonyl aliphatic compounds is proposed by the application of the molecular tailoring approach (MTA) based on calculations at the second-order Moller-Plesset MP2 level.	Hydrogen	71-79	tryptase pseudogene 1	Homo sapiens	274-277
3169242-1	1988	The proton NMR characterization of bombesin has been carried out at 500 MHz in DMSO-d6 using two-dimensional homo- and 1H-13C hetero-correlated techniques.	Hydrogen	119-121	gastrin releasing peptide	Homo sapiens	35-43
24923328-1	2014	A heterogeneous dihydrogen (H2) production system has been attained by simply soaking electrodes made from electro-deposited graphene on FTO plated glass in solutions of a cobalt bis(dithiolate) compound.	Hydrogen	16-26	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	137-140
2973811-3	1988	The 1H NMR resonances of ANF(7-23) in SDS micelles were assigned using sequential assignment techniques, and the conformational properties were analyzed primarily from proton-proton distances obtained from the quantitative analysis of two-dimensional nuclear Overhauser effect spectra.	Hydrogen	4-6	natriuretic peptide A	Rattus norvegicus	25-28
24923328-1	2014	A heterogeneous dihydrogen (H2) production system has been attained by simply soaking electrodes made from electro-deposited graphene on FTO plated glass in solutions of a cobalt bis(dithiolate) compound.	Hydrogen	28-30	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	137-140
3416869-8	1988	The lectins are involved in strong hydrogen bonds through charged groups with the C-3 and C-4 hydroxyl groups of galactose, with the latter serving as hydrogen-bond donors.	Hydrogen	35-43	complement C3	Homo sapiens	82-85
24930496-16	2014	Interestingly, urea, choline, and chloride ions form hydrogen bonds with the surface residues of the enzyme which, instead of lipase denaturation, leads to greater enzyme stability.	Hydrogen	53-61	PAN0_003d1715	Moesziomyces antarcticus	126-132
3416869-8	1988	The lectins are involved in strong hydrogen bonds through charged groups with the C-3 and C-4 hydroxyl groups of galactose, with the latter serving as hydrogen-bond donors.	Hydrogen	151-159	complement C3	Homo sapiens	82-85
24975933-2	2014	The precursor chloroborane ClB{1,8-(NH)2C10H6} (I) is fully characterized including its crystal structure, which features intermolecular pi-pi stacking, B   N interactions, and N-H   Cl hydrogen bonding.	Hydrogen	186-194	citramalyl-CoA lyase	Homo sapiens	27-30
3260670-1	1988	Two-dimensional 1H NMR investigations were used to locate elements of regular secondary structure in the human complement protein C3a (the des-Arg77 derivative) in solution.	Hydrogen	16-18	complement C3	Homo sapiens	130-133
2853669-3	1988	The presence of water led to the maintenance of the 2"-GMP-RNase T1 interactions as compared to the X-ray structure, including the hydrogen bonds implicated in the enzyme-inhibitor recognition process.	Hydrogen	131-139	5'-nucleotidase, cytosolic II	Homo sapiens	55-58
15540241-14	2004	The hypersurface for the reaction of H(2)OOH(+) with CH(3)Cl and C(2)H(5)Cl was calculated at the B3 LYP, MP2, and G3(m*) level, underlining the three mechanistic scenarios in which the reaction is either induced by oxidation at the hydrogen or the halogen atom, or by proton transfer.	Hydrogen	233-241	tryptase pseudogene 1	Homo sapiens	106-109
24740651-0	2014	Co-existence of two different alpha-synuclein oligomers with different core structures determined by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	101-109	synuclein alpha	Homo sapiens	30-45
2448480-4	1987	Calculations based on the assumption that the exchange mechanism involves local unfolding lead to quantitative agreement between the calculated and experimentally measured exchange rates for 80% of the amides of BPTI that are buried or hydrogen bonded to the main-chain or to internal water molecules.	Hydrogen	236-244	spleen trypsin inhibitor I	Bos taurus	212-216
24740651-3	2014	Hydrogen/deuterium exchange (HDX) monitored by mass spectrometry is used to analyze oligomers formed by wild-type (wt) alphaSN and also three familial alphaSN mutants (A30P, E46K, and A53T).	Hydrogen	0-8	synuclein alpha	Homo sapiens	119-126
15584729-3	2004	A novel gamma N-O turn involving a 10-membered-ring intramolecular hydrogen bond between NHi+2 and COi is formed in gamma4-aminoxy peptides 2 and 3.	Hydrogen	67-75	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	99-102
24740651-3	2014	Hydrogen/deuterium exchange (HDX) monitored by mass spectrometry is used to analyze oligomers formed by wild-type (wt) alphaSN and also three familial alphaSN mutants (A30P, E46K, and A53T).	Hydrogen	0-8	synuclein alpha	Homo sapiens	151-158
25083348-11	2014	The membrane topography of SP-C mimics was investigated with orientated and hydrogen/deuterium (H/D) exchange FTIR, and also Membrane Protein Explorer (MPEx) hydropathy analysis.	Hydrogen	76-84	pulmonary surfactant-associated protein C	Oryctolagus cuniculus	27-31
15563145-5	2004	The higher thermal reactivity of 2d versus that of 1 and 2b,c is attributed to steric crowding associated with the Cp* ligands of 2d, which forces a ClPh ortho-hydrogen close to the Zr-Me group.	Hydrogen	160-168	calcium binding protein, spermatid associated 1	Homo sapiens	149-153
3571255-5	1987	Lineshape analyses of several 1H NMR resonances generated by the Lu(III) titration of Ca2-oncomodulin indicated that Ca(II)----Ln(III) exchange at the CD site was 15-20 s-1, approximately 100 times faster than exchange at the CD site of parvalbumins.	Hydrogen	30-32	carbonic anhydrase 2	Homo sapiens	117-123
3567457-11	1987	We suggest that the hydrolysis of inositol phospholipids may be involved in the signal transduction mechanism by which the activation of the muscarinic and gastrin receptors on the parietal cells leads to Ca2+ mobilization and the stimulation of hydrogen ion secretion.	Hydrogen	246-254	gastrin	Rattus norvegicus	156-163
24709521-1	2014	This study presents a tumor-extracellular matrix pH-induced targeting liposome (ECM-targeting liposomes), crosslinked from methoxy-poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide-co-histidine)-cholesterol copolymers and biotin2-polyethylene glycol crosslinkers by hydrogen bonds to overcome the defects of liposomes.	Hydrogen	278-286	multimerin 1	Homo sapiens	80-83
15554712-1	2004	Using amide hydrogen exchange combined with electrospray ionization mass spectrometry, we have in this study determined the number of amide hydrogens on several peptides that become solvent-inaccessible as a result of their high-affinity interaction with the urokinase-type plasminogen activator receptor (uPAR).	Hydrogen	140-149	plasminogen activator, urokinase receptor	Homo sapiens	259-304
15554712-1	2004	Using amide hydrogen exchange combined with electrospray ionization mass spectrometry, we have in this study determined the number of amide hydrogens on several peptides that become solvent-inaccessible as a result of their high-affinity interaction with the urokinase-type plasminogen activator receptor (uPAR).	Hydrogen	140-149	plasminogen activator, urokinase receptor	Homo sapiens	306-310
15554712-2	2004	These experiments reveal that at least six out of eight amide hydrogens in a synthetic nine-mer peptide antagonist (AE105) become sequestered upon engagement in uPAR binding.	Hydrogen	62-71	plasminogen activator, urokinase receptor	Homo sapiens	161-165
15554712-4	2004	The isolated growth factor-like domain (GFD) of the cognate serine protease ligand for uPAR showed 11 protected amide hydrogens in the receptor complex.	Hydrogen	118-127	plasminogen activator, urokinase receptor	Homo sapiens	87-91
15554712-5	2004	Interestingly, a naturally occurring O-linked fucose on Thr(18) confers protection of two additional amide hydrogens in GFD when it forms a complex with uPAR.	Hydrogen	107-116	plasminogen activator, urokinase receptor	Homo sapiens	153-157
3789144-3	1986	Infusion of PAF (25-100 ng X kg-1 X min-1 iv) dose-dependently reduced systemic arterial blood pressure and mucosal blood flow, as determined by hydrogen gas clearance.	Hydrogen	145-153	PCNA clamp associated factor	Rattus norvegicus	12-44
15554712-6	2004	Dissociation of the uPAR-peptide complexes is accompanied by a correlated exchange of nearly all amide hydrogens on the peptide ligand.	Hydrogen	103-112	plasminogen activator, urokinase receptor	Homo sapiens	20-24
3790504-8	1986	The data support a mechanism in which a single base catalyzes a 1,3-prototrophic shift of hydrogen from C-1 of the substrate to cofactor, followed by exchange from C-2.	Hydrogen	90-98	complement C2	Bos taurus	164-167
24893121-0	2014	Synthesis and crystal structure of new temephos analogues as cholinesterase inhibitor: molecular docking, QSAR study, and hydrogen bonding analysis of solid state.	Hydrogen	122-130	butyrylcholinesterase	Homo sapiens	61-75
24840168-0	2014	Cysteine-mediated dynamic hydrogen-bonding network in the active site of Pin1.	Hydrogen	26-34	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	73-77
3271438-4	1986	There are two hydrogen bonds formed between the mismatch bases, N-1 and O-6 of guanine with N-7 and N-6 of adenine respectively.	Hydrogen	14-22	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	64-75
15515086-1	2004	Hydrogen bonding plays a key role in the tight binding of the FMN cofactor and the regulation of its redox properties in flavodoxins.	Hydrogen	0-8	formin 1	Homo sapiens	62-65
3021361-1	1986	Spin-echo 1H nuclear magnetic resonance (nmr) spectra of urine from two unrelated patients with 3-oxoacylthiolase deficiency are presented.	Hydrogen	10-12	spindlin 1	Homo sapiens	0-4
24840168-5	2014	Here, we show that the protonation state of Cys113 mediates a dynamic hydrogen-bonding network in the active site of Pin1, involving the two adjacent histidines and several other residues that are highly conserved and necessary for catalysis.	Hydrogen	70-78	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	117-121
15317475-2	2004	In order to gain insight into structure-function relationship, three-dimensional structure of NKB has been investigated using CD spectropolarimetry and two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy in aqueous and membrane mimetic solvents.	Hydrogen	206-208	tachykinin precursor 3	Homo sapiens	94-97
15557810-0	2004	1H, 13C and 15N resonance assignment of the reduced form of thioredoxin h1 from Poplar, a CPPC active site variant.	Hydrogen	0-2	thioredoxin	Homo sapiens	60-71
15325268-3	2004	The early increase in the Tg synthesis within 1h after stimulation apparently triggers UPR as it is evidenced by the activation of ATF6- and PERK-dependent pathways of UPR and subsequent expression of the UPR target genes, ER molecular chaperones.	Hydrogen	46-48	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	141-145
3022124-1	1986	A comparative study of the interaction of proflavine with isomeric diribonucleoside monophosphates CpG and GpC has been made by the method of 1H NMR (270 MHz).	Hydrogen	142-144	glycophorin C (Gerbich blood group)	Homo sapiens	107-110
24896569-6	2014	Western blot analyses revealed that Ang1 expression levels on the ischemic side of the cerebral cortex were decreased in the tPA-1h, tPA-4h, and PMCAO groups as compared to those in the control group (P = 0.014, 0.003, and 0.014, respectively).	Hydrogen	129-131	angiopoietin 1	Rattus norvegicus	36-40
3719908-5	1986	The C-C(methyl) bonds are bent so that angles C(10)-C(1)-C(14) and C(13)-C(8)-C(15) are about 123 degrees, while the methyl groups are orientated with one hydrogen from each pointing away from the carbonyl group.	Hydrogen	155-163	chromosome 12 open reading frame 57	Homo sapiens	46-51
24896569-7	2014	Ang1-positive vessel densities in the tPA-4h and PMCAO groups were less than that in the control group (p = 0.002 and &lt;0.001, respectively) as well as that in the tPA-1h group (p = 0.047 and 0.005, respectively).	Hydrogen	170-172	angiopoietin 1	Rattus norvegicus	0-4
24892548-6	2014	Comparison of the crystal structures of the VH variants revealed that those substitutions with bulky side chain amino acids filled the cavity in the VH interface between heavy and light chains of the Fab arrangement along with the increased number of hydrogen bonds, decreased solvation energy, and increased negative charge.	Hydrogen	251-259	FA complementation group B	Homo sapiens	200-203
2423149-3	1986	From the analyses by NMR, CD, and IR measurements, intramolecular hydrogen bonds were found in the sequential peptides with n larger than two and Boc-(Leu-Leu-D-Phe-Pro)3-OBzl was deduced to adopt a 3(10)-helical conformation.	Hydrogen	66-74	BOC cell adhesion associated, oncogene regulated	Homo sapiens	146-149
3707919-2	1986	Comparison of 1H NMR spectra between the alpha and gamma subforms suggested that peak 1 of the alpha subform at 8.89 ppm contains a resonance assignable to the internal aldimine 4"-H.	Hydrogen	14-16	pseudopodium enriched atypical kinase 1	Homo sapiens	81-87
15263072-2	2004	To further the current understanding of protein adsorption, in this study, the orientation, conformation, and local stability of bovine alpha-lactalbumin (BLA) adsorbed on polystyrene nanospheres is characterized at the residue level by hydrogen/deuterium exchange and 2D NMR spectroscopy.	Hydrogen	237-245	lactalbumin alpha	Bos taurus	136-153
24770803-6	2014	From the results, the global properties like root mean square deviation, root mean square fluctuation, radius of gyration, solvent accessible surface area and hydrogen bonds showed structural changes in atomic level observed in W32G and W32G/K87A laforin mutants.	Hydrogen	159-167	EPM2A glucan phosphatase, laforin	Homo sapiens	247-254
15271520-0	2004	1H NMR relaxometric characterization of bovine lactoferrin.	Hydrogen	0-2	lactotransferrin	Bos taurus	47-58
15227536-1	2004	Relative to the rate observed for the hexa-aqua ion, Cu(OH(2))(6)(2+), chelation of the copper catalyst by certain bidentate ligands enhances the rate of hydroxydediazoniation reaction (Sandmeyer hydroxylation); the ligands also provide a source of hydrogen in competitive hydrodediazoniation (H-transfer) reactions.	Hydrogen	249-257	hexosaminidase subunit alpha	Homo sapiens	38-42
3711061-4	1986	500-MHz 1H-NMR spectroscopy in conjunction with sequential exoglycosidase digestion of the reduced compounds revealed that each of the three fractions consisted of a single isomer only; the Man9 compound has the following structure: (Formula: see tex).	Hydrogen	8-10	mannosidase alpha class 1A member 1	Homo sapiens	190-194
3964660-1	1986	The in vitro hydrolysis by porcine kidney prolidase of the imidodipeptide L-alanyl-L-proline was monitored by using 1H high-resolution NMR spectroscopy.	Hydrogen	116-118	peptidase D	Homo sapiens	42-51
3964660-7	1986	1H NMR time courses of the prolidase-catalyzed hydrolysis of L-alanyl-L-proline showed a faster removal of the trans isomer as the [enzyme]/[substrate] ratio was increased.	Hydrogen	0-2	peptidase D	Homo sapiens	27-36
15213456-0	2004	1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain.	Hydrogen	0-2	sprouty related EVH1 domain containing 2	Homo sapiens	50-56
24830333-2	2014	The CoP/CC, as a robust integrated 3D hydrogen-evolving cathode, shows a low onset overpotential of 38 mV and a small Tafel slope of 51 mV dec(-1), and it maintains its catalytic activity for at least 80,00 s in acidic media.	Hydrogen	38-46	caspase recruitment domain family member 16	Homo sapiens	4-7
15248964-1	2004	We present a theoretical study through MP2 ab initio molecular orbital calculations and B3LYP density functional theory with the 6-311++G(d,p) basis set of the heterocyclic hydrogen complexes, CnHmY-HX, where CnHmY = C2H4O, C2H5N and C2H4S, and X=F or Cl.	Hydrogen	173-181	tryptase pseudogene 1	Homo sapiens	39-42
3754548-4	1986	Since a 18OH group was introduced at C-3 on a hydrolytic cleavage of C-2, C-3 epoxy group with alkaline H2(18)O, the original epoxy oxygen should be retained at C-2.	Hydrogen	104-106	complement C3	Homo sapiens	37-40
3754862-8	1986	1H NMR studies suggested that the pale colored species was a complex of fully reduced adrenodoxin reductase and NADPH, and that the semiquinone also bound 1 mol of the pyridine nucleotide per mol of the reductase.	Hydrogen	0-2	2,4-dienoyl-CoA reductase 1	Homo sapiens	112-117
3866515-2	1985	Replacement of the 3-hydroxyl of T-2 with hydrogen caused a 24-fold decrease in activity, whereas acetylation resulted in a 500-to 1,000-fold decrease.	Hydrogen	42-50	solute carrier family 25 member 5	Homo sapiens	33-36
15100222-0	2004	Identification of CRALBP ligand interactions by photoaffinity labeling, hydrogen/deuterium exchange, and structural modeling.	Hydrogen	72-80	retinaldehyde binding protein 1	Homo sapiens	18-24
24645846-3	2014	Comparative structural and binding studies between PYL9, which is a representative of high-affinity subfamily I, and low-affinity members of subfamily III reveals that the nonpolar triplet (Ile110, Val162, and Leu165) and Pro64 contribute to enhance ABA-binding affinity by inducing a shift of the ABA carboxyl group to form additional direct hydrogen bonds with conserved Asn169.	Hydrogen	343-351	regulatory component of ABA receptor 1	Arabidopsis thaliana	51-55
15170323-6	2004	Glu75 of SHMT is clearly involved in the reaction mechanism; it is within hydrogen bonding distance of the hydroxyl group of serine and the formyl group of 5-formyltetrahydrofolate in complexes of these species with SHMT.	Hydrogen	74-82	serine hydroxymethyltransferase 1	Homo sapiens	9-13
15170323-6	2004	Glu75 of SHMT is clearly involved in the reaction mechanism; it is within hydrogen bonding distance of the hydroxyl group of serine and the formyl group of 5-formyltetrahydrofolate in complexes of these species with SHMT.	Hydrogen	74-82	serine hydroxymethyltransferase 1	Homo sapiens	216-220
15252617-3	2004	Treating complex with NH4SCN and dipyridyl led to the formation of dinuclear rods, [Cp*Rh(eta1-SCN)3]2(LH2) (5a: L = bpy; 5b: L = bpe), in which two Cp*Rh(eta1-SCN)3 units are connected by the diprotonated dipyridyl (LH2(2+)) through N(+)-H...N hydrogen bonds.	Hydrogen	245-253	secreted phosphoprotein 1	Homo sapiens	90-94
2933070-0	1985	1H NMR studies of lambda cro repressor.	Hydrogen	0-2	cro	Escherichia virus Lambda	25-28
9895742-0	1985	Spin-exchange cross sections for hydrogen-atom-alkali-metal-atom collisions.	Hydrogen	33-41	spindlin 1	Homo sapiens	0-4
24699735-4	2014	The TSH2B Ser85 residue does not interact with H4 in the nucleosome, but in the canonical nucleosome the H2B Asn84 residue (corresponding to the TSH2B Ser85 residue) forms water-mediated hydrogen bonds with the H4 Arg78 residue.	Hydrogen	187-195	H2B clustered histone 1	Homo sapiens	4-9
3871641-13	1985	Our present study demonstrates that ABH antigens on platelets consist of type 2H chains, which are presumably intrinsic as when found on red cells, and of passively adsorbed ABH structures, which are presumably type 1H chains.	Hydrogen	216-218	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	36-39
15136672-4	2004	METHOD: S AND RESULTS: 1H-NMR of CSF in both girls was performed repeatedly, and both showed highly elevated concentrations of N-acetylaspartylglutamate (NAAG).	Hydrogen	23-25	colony stimulating factor 2	Homo sapiens	33-36
24699735-4	2014	The TSH2B Ser85 residue does not interact with H4 in the nucleosome, but in the canonical nucleosome the H2B Asn84 residue (corresponding to the TSH2B Ser85 residue) forms water-mediated hydrogen bonds with the H4 Arg78 residue.	Hydrogen	187-195	H2B clustered histone 21	Homo sapiens	6-9
3923562-6	1985	The results are interpreted on the basis that hydrogen removal by the lipoxygenase is from C10 and by the cyclooxygenase from C13 but only in 20:35,11,14 are these hydrogens (C13) located at the center of a 1,4 cis cis pentadiene system (ethylenic) or a 1,4 pentadiyne system (acetylenic).	Hydrogen	46-54	homeobox C13	Homo sapiens	126-129
24699735-4	2014	The TSH2B Ser85 residue does not interact with H4 in the nucleosome, but in the canonical nucleosome the H2B Asn84 residue (corresponding to the TSH2B Ser85 residue) forms water-mediated hydrogen bonds with the H4 Arg78 residue.	Hydrogen	187-195	H2B clustered histone 1	Homo sapiens	145-150
3923562-6	1985	The results are interpreted on the basis that hydrogen removal by the lipoxygenase is from C10 and by the cyclooxygenase from C13 but only in 20:35,11,14 are these hydrogens (C13) located at the center of a 1,4 cis cis pentadiene system (ethylenic) or a 1,4 pentadiyne system (acetylenic).	Hydrogen	46-54	homeobox C13	Homo sapiens	175-178
3923562-6	1985	The results are interpreted on the basis that hydrogen removal by the lipoxygenase is from C10 and by the cyclooxygenase from C13 but only in 20:35,11,14 are these hydrogens (C13) located at the center of a 1,4 cis cis pentadiene system (ethylenic) or a 1,4 pentadiyne system (acetylenic).	Hydrogen	164-173	homeobox C13	Homo sapiens	175-178
15122640-2	2004	We quantify the effect of replacing a hydrogen residue by a chlorine or a trifluoromethyl residue in position C-2 of promazine, perazine, and perphenazine analogues.	Hydrogen	38-46	complement C2	Homo sapiens	110-113
23264024-0	2014	1H, 13C and 15N assignments of the four N-terminal domains of human fibrillin-1.	Hydrogen	0-2	fibrillin 1	Homo sapiens	68-79
24165164-7	2014	Furthermore, ability to inhibit both MAO-A and MAO-B can be potentialized by the formation of hydrogen bonds between these compounds and FAD and/or the residues in the active site.	Hydrogen	94-102	monoamine oxidase A	Homo sapiens	37-42
15066431-5	2004	The model is consistent with NMR spectra of GTPase-bound WASP, and accurately predicts changes of amide hydrogen exchange behavior and Cdc42 affinity as a function of WASP stability.	Hydrogen	104-112	WASP actin nucleation promoting factor	Homo sapiens	57-61
15066431-5	2004	The model is consistent with NMR spectra of GTPase-bound WASP, and accurately predicts changes of amide hydrogen exchange behavior and Cdc42 affinity as a function of WASP stability.	Hydrogen	104-112	WASP actin nucleation promoting factor	Homo sapiens	167-171
14722099-5	2004	The C-terminal extension of beta7/Pre4, which forms several hydrogen bonds with beta1/Pre3, is in addition required for the post-acidic activity mediated by the latter subunit.	Hydrogen	60-68	proteasome core particle subunit beta 7	Saccharomyces cerevisiae S288C	28-38
15028267-6	2004	The 2-ethynyl derivative 1h (pA(2)=7.54+/-0.10) was significantly more potent (10-fold) as an antagonist when compared to the reference 1a, revealing a potential electronic interaction highly favorable between triple bond orbitals and the P2Y(1) receptor at this position.	Hydrogen	25-27	purinergic receptor P2Y1	Homo sapiens	239-254
15010226-4	2004	Bovine MAIL mRNA was undetectable in isolated peripheral white blood cells, but rapidly induced (&lt;1h) after stimulation by LPS and lipid A in vitro in a dose-dependent manner.	Hydrogen	101-103	NFKB inhibitor zeta	Bos taurus	7-11
15037083-0	2004	Equilibrium and kinetic folding of rabbit muscle triosephosphate isomerase by hydrogen exchange mass spectrometry.	Hydrogen	78-86	triosephosphate isomerase	Oryctolagus cuniculus	49-74
15037083-1	2004	Unfolding and refolding of rabbit muscle triosephosphate isomerase (TIM), a model for (betaalpha)8-barrel proteins, has been studied by amide hydrogen exchange/mass spectrometry.	Hydrogen	142-150	triosephosphate isomerase	Oryctolagus cuniculus	68-71
15004375-1	2004	The molecules of the title compound, C11H14BrNO2, are assembled into a two-dimensional network by a combination of hydrogen bonds and stacking interactions.	Hydrogen	115-123	NLR family pyrin domain containing 12	Homo sapiens	37-48
14638688-7	2004	These results indicated that the reduced pKa value of Glu380 is stabilized by the hydrogen bond network and is responsible for the lower pH optimum of soybean beta-amylase compared with that of the bacterial beta-amylase.	Hydrogen	82-90	beta-amylase	Glycine max	159-171
14670455-5	2004	The corrected values of the dissociation energy at the SCF and MP2 levels and B3LYP calculations are indicative of relatively strong OH...O hydrogen-bonded interaction.	Hydrogen	140-148	tryptase pseudogene 1	Homo sapiens	63-66
14677931-1	2003	Dilute solutions of (R)-(-)-pantolactone in CCl4 were studied by polarimetry in conjunction with theoretical calculations of [alpha]D. Our data demonstrate that the self-association of a chiral solute results in a change in [alpha]D that can be accounted for by the presence of hydrogen-bonded dimeric species.	Hydrogen	278-286	C-C motif chemokine ligand 4	Homo sapiens	44-48
14643664-4	2003	In the closed conformation described here, the lid loop residues participate in stabilizing hydrogen bonds characteristic of holo TIM structures, whereas chemical interactions observed in the open loop conformation are similar to those found in the apo structures of TIM.	Hydrogen	92-100	triosephosphate isomerase	Oryctolagus cuniculus	267-270
14653744-0	2003	Hydrogen bonding interfaces in fullerene*TTF ensembles.	Hydrogen	0-8	ras homolog family member H	Homo sapiens	41-44
14599211-5	2003	In the case of glycosaminoglycan-derived amidyl radicals, evidence has been obtained in studies with model glycosides that these radicals undergo rapid intramolecular abstraction reactions to give carbon-centered radicals at C-2 on the N-acetyl glycosamine rings (via a 1,2-hydrogen atom shift) and at C-4 on the neighboring uronic acid residues (via 1,5-hydrogen atom shifts).	Hydrogen	274-282	complement C2	Homo sapiens	225-228
14599211-5	2003	In the case of glycosaminoglycan-derived amidyl radicals, evidence has been obtained in studies with model glycosides that these radicals undergo rapid intramolecular abstraction reactions to give carbon-centered radicals at C-2 on the N-acetyl glycosamine rings (via a 1,2-hydrogen atom shift) and at C-4 on the neighboring uronic acid residues (via 1,5-hydrogen atom shifts).	Hydrogen	274-282	complement C4A (Rodgers blood group)	Homo sapiens	302-305
14599211-5	2003	In the case of glycosaminoglycan-derived amidyl radicals, evidence has been obtained in studies with model glycosides that these radicals undergo rapid intramolecular abstraction reactions to give carbon-centered radicals at C-2 on the N-acetyl glycosamine rings (via a 1,2-hydrogen atom shift) and at C-4 on the neighboring uronic acid residues (via 1,5-hydrogen atom shifts).	Hydrogen	355-363	complement C2	Homo sapiens	225-228
14599211-5	2003	In the case of glycosaminoglycan-derived amidyl radicals, evidence has been obtained in studies with model glycosides that these radicals undergo rapid intramolecular abstraction reactions to give carbon-centered radicals at C-2 on the N-acetyl glycosamine rings (via a 1,2-hydrogen atom shift) and at C-4 on the neighboring uronic acid residues (via 1,5-hydrogen atom shifts).	Hydrogen	355-363	complement C4A (Rodgers blood group)	Homo sapiens	302-305
14580712-8	2003	This effect is assumed to originate from headgroup-headgroup interactions, and most probably hydrogen bonding, between amide and phosphate groups of the PEG-surfactant and the EPC, respectively.	Hydrogen	93-101	progestagen associated endometrial protein	Homo sapiens	153-156
14599021-11	2003	The C-5 OH group is involved in strong intramolecular hydrogen bonding leading to a pseudo aromatic ring extending the aromatic part of the drug pharmacophore.	Hydrogen	54-62	complement C5	Homo sapiens	4-7
14644556-0	2003	1H NMR studies of the effect of mutation at Valine45 on heme microenvironment of cytochrome b5.	Hydrogen	0-2	cytochrome b5 type A	Homo sapiens	81-94
12829692-9	2003	Moreover, preliminary 15N-1H heteronuclear single quantum coherence spectra obtained with Atp11pTRNC indicate that the truncated protein is well ordered and amenable to structure determination by nuclear magnetic resonance.	Hydrogen	26-28	Atp11p	Saccharomyces cerevisiae S288C	90-95
12972557-8	2003	Targeting of MHCI heavy chains for dislocation by US11 thus requires the formation of interhelical hydrogen bonds within the ER membrane.	Hydrogen	99-107	membrane glycoprotein US11	Human betaherpesvirus 5	50-54
12926963-4	2003	In the second step, the same hydrogen abstracted by the N-terminal Pro-1 is shuttled back to the fifth carbon of the substrate to form the product, 2-oxo-3-hexenedioate.	Hydrogen	29-37	lamin A/C	Homo sapiens	67-72
12820886-0	2003	The three-dimensional structure of bovine calcium ion-bound osteocalcin using 1H NMR spectroscopy.	Hydrogen	78-80	bone gamma-carboxyglutamate protein	Bos taurus	60-71
12728361-3	2003	The methyl radical, concomitantly released by methyl-coenzyme M (CoM), is rapidly quenched by hydrogen atom transfer from the coenzyme B (CoB) thiol group, yielding methane as the first product of the reaction.	Hydrogen	94-102	metabolism of cobalamin associated B	Homo sapiens	126-136
12766423-0	2003	1H, 13C and 15N backbone resonance assignments of the N-terminal domain of Drosophila GCM protein.	Hydrogen	0-2	glial cells missing	Drosophila melanogaster	86-89
12842049-5	2003	The corresponding Y329S mutation in PDE7 may lead to loss of the hydrogen bonds between rolipram and Gln369 and is thus a possible reason explaining PDE7"s insensitivity to rolipram inhibition.	Hydrogen	65-73	phosphodiesterase 7A	Homo sapiens	36-40
12842049-5	2003	The corresponding Y329S mutation in PDE7 may lead to loss of the hydrogen bonds between rolipram and Gln369 and is thus a possible reason explaining PDE7"s insensitivity to rolipram inhibition.	Hydrogen	65-73	phosphodiesterase 7A	Homo sapiens	149-153
12809220-1	2003	[Cu4(mu-dppm)4(mu4-eta1,eta2-C[triple bond]C-)]2+ has been shown by 31P and 1H NMR studies to undergo two fluxional processes in solution, the oscillation of the C[triple bond]C2- unit inside the copper rectangle and the flipping of the diphosphines, and this has been supported by DFT(B3LYP) calculations.	Hydrogen	76-78	secreted phosphoprotein 1	Homo sapiens	19-23
12877331-5	2003	Although some permeants (which are highly bound to zein) interact through electrostatic interaction, van der Waals, hydrophobic, and hydrogen bonding interactions, they did not alter membrane swelling behavior significantly.	Hydrogen	133-141	zein	Zea mays	51-55
12492399-1	2003	Heparan sulphate 6- O -sulphotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3"-phosphate, 5"-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in HS.	Hydrogen	42-44	heparan sulfate 6-O-sulfotransferase 1	Homo sapiens	0-40
12586353-0	2003	NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes.	Hydrogen	65-73	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	0-7
12586353-1	2003	Sodium-hydrogen exchanger regulatory factor isoform-1 (NHERF-1) and NHERF-2 are two structurally related PDZ-domain-containing protein adapters that effectively transduce cyclic AMP (cAMP) signals that inhibit NHE3, the sodium-hydrogen exchanger isoform present at the apical surface of kidney and gut epithelia.	Hydrogen	7-15	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	55-62
12517147-9	2003	Structural comparison of TcAChE with rat AChE, as represented by the closely related mouse AChE structure (1maa.pdb), reveals a narrower gorge for rat AChE, a perpendicular alignment of the Tyr337 ring to the gorge axis, and its conformational rigidity, as a result of hydrogen bonding between its hydroxyl group and that of Tyr341, relative to TcAChE Phe330.	Hydrogen	269-277	acetylcholinesterase	Rattus norvegicus	27-31
12517147-9	2003	Structural comparison of TcAChE with rat AChE, as represented by the closely related mouse AChE structure (1maa.pdb), reveals a narrower gorge for rat AChE, a perpendicular alignment of the Tyr337 ring to the gorge axis, and its conformational rigidity, as a result of hydrogen bonding between its hydroxyl group and that of Tyr341, relative to TcAChE Phe330.	Hydrogen	269-277	acetylcholinesterase	Rattus norvegicus	41-45
12452690-0	2002	1H NMR detection of immobilized water molecules within a strong distal hydrogen-bonding network of substrate-bound human heme oxygenase-1.	Hydrogen	0-2	heme oxygenase 1	Homo sapiens	121-137
12452690-0	2002	1H NMR detection of immobilized water molecules within a strong distal hydrogen-bonding network of substrate-bound human heme oxygenase-1.	Hydrogen	71-79	heme oxygenase 1	Homo sapiens	121-137
12377023-3	2002	For example, both FeX(2) and [Ru(eta(4)-1,5-COD)X(2)], X = Cl and Br, react with PhMgBr solutions under hydrogen to produce the title compounds.	Hydrogen	104-112	stabilin 2	Homo sapiens	18-23
12242100-3	2002	Activin A stimulated FSH release and effect appeared 1h after injection (168% increase of controls) reaching a maximum at 3h (437% of controls).	Hydrogen	53-55	inhibin subunit beta A	Rattus norvegicus	0-9
12206413-4	2002	The 1H-NMR allowed individually monitoring the fate of the alkyl and polyethoxyl fragments of the parent compounds and distinguishing between oxidative and nonoxidative polyethoxyl depolymerization, which could not be performed by other reported techniques such as high-peformance liquid chromatography (HPLC) or mass spectrometry (MS) or FAB spectroscopy.	Hydrogen	4-6	FA complementation group B	Homo sapiens	339-342
12602951-4	2002	The statistical analysis of the results reveals that the GMIP functional, which combines electrostatic and steric energy components, predicts with reasonable accuracy and computational efficiency the hydrogen-bond strength for a wide variety of compounds.	Hydrogen	200-208	GEM interacting protein	Homo sapiens	57-61
12465490-1	2002	Weak hydrogen bonding was studied in the XH...OH2 and X3CH...OH2 complexes (X = F, Cl, Br, I) using the correlated MP2 ab initio method with relativistic Stuttgart/Dresden pseudopotentials and basis set (SDD).	Hydrogen	5-13	tryptase pseudogene 1	Homo sapiens	115-118
12112346-3	2002	The chiral recognition mechanism exerted by CSP 1 for the resolution of anilide derivatives of N-acyl-alpha-amino acids is proposed to involve a face-to-face pi-pi interaction and two hydrogen bonding interactions between the CSP and the analytes from the chromatographic resolution behaviors of slightly modified anilide derivatives of N-acyl-alpha-amino acids.	Hydrogen	184-192	regulator of calcineurin 1	Homo sapiens	44-49
12120950-2	2002	The aim of this study was to determine the stereochemistry of the hydroperoxides formed during autoxidation of CLA methyl ester in the presence of a good hydrogen atom donor.	Hydrogen	154-162	selectin P ligand	Homo sapiens	111-114
12120950-9	2002	The autoxidation of 9-cis,11-trans CLA methyl ester in the presence of a good hydrogen atom donor is stereoselective in favor of one geometric isomer, namely the 13-(R,S)-hydroperoxy-9-cis,11-trans-octadecadienoic acid methyl ester.	Hydrogen	78-86	selectin P ligand	Homo sapiens	35-38
11996574-9	2002	Apart from its mechanistic implications, this atomic resolution structure affords an unusually detailed view of the structure, dynamics, and hydrogen-bonding networks of TEM-1, which may be useful for the design of inhibitors against this key antibiotic resistance target.	Hydrogen	141-149	CD248 molecule	Homo sapiens	170-175
3880742-4	1985	One important consequence of this deeper insertion of the pyrimidine into the active site of chicken dihydrofolate reductase is the loss of a potential hydrogen bond that would otherwise form between the carbonyl oxygen of Val-115 and the inhibitor"s 4-amino group.	Hydrogen	152-160	dihydrofolate reductase	Gallus gallus	101-124
3880743-7	1985	The crystallographic evidence strongly suggests that loss of a potential hydrogen bond between the 4-amino group of TMP and the backbone carbonyl of Val-115 when TMP binds to chicken dihydrofolate reductase but not when it binds to the E. coli reductase is the major factor responsible for this drug"s more potent inhibition of bacterial dihydrofolate reductase.	Hydrogen	73-81	dihydrofolate reductase	Gallus gallus	183-206
3880743-7	1985	The crystallographic evidence strongly suggests that loss of a potential hydrogen bond between the 4-amino group of TMP and the backbone carbonyl of Val-115 when TMP binds to chicken dihydrofolate reductase but not when it binds to the E. coli reductase is the major factor responsible for this drug"s more potent inhibition of bacterial dihydrofolate reductase.	Hydrogen	73-81	dihydrofolate reductase	Gallus gallus	338-361
6745423-2	1984	The oxidizability of a redox couple, [4Fe-4S], in a 7Fe ferredoxin extracted from Pseudomonas ovalis was monitored by 1H-NMR.	Hydrogen	118-120	ferredoxin	Pseudomonas putida	56-66
6432037-0	1984	Paramagnetic 1H and 13C NMR studies on cobalt-substituted human carbonic anhydrase I carboxymethylated at active site histidine-200: molecular basis for the changes in catalytic properties induced by the modification.	Hydrogen	13-15	carbonic anhydrase 1	Homo sapiens	64-84
6233535-0	1984	1H NMR study of the interaction of bacteriophage lambda Cro protein with the OR3 operator.	Hydrogen	0-2	cro	Escherichia virus Lambda	56-59
6701098-2	1984	The 1H, 13C, 15N NMR spectra of cytidine /Cyd/, ethenocytidine /epsilon Cyd/ and their hydrochlorides /Cyd X HC1/ and /epsilon Cyd X HC1/ have been analysed to compare structural differences observed in solution with those existing in the crystalline state.	Hydrogen	4-6	CYCS pseudogene 39	Homo sapiens	109-112
6692823-0	1984	Studies on the dynamic syn-anti equilibrium in purine nucleosides and nucleotides with the aid of 1H and 13C NMR spectroscopy.	Hydrogen	98-100	synemin	Homo sapiens	23-26
6692823-1	1984	Analyses of 1H and 13C NMR spectra have been utilized to extend studies on the dynamic equilibrium syn-anti about the glycosidic bond of purine nucleosides and nucleotides.	Hydrogen	12-14	synemin	Homo sapiens	99-102
6863249-2	1983	For both complexes, the orientation allowing optimal hydrogen bonding involves interaction between negatively charged residues on cytochrome b5 and positively charged residues on methemoglobin.	Hydrogen	53-61	hemoglobin subunit gamma 2	Homo sapiens	179-192
6306249-0	1983	Characterization of the proteinase inhibitor IIA from bull seminal plasma by 1H nuclear magnetic resonance.	Hydrogen	77-79	endogenous retrovirus group K member 10	Homo sapiens	24-34
6220002-1	1983	We present here the complete identification of the resonances from the aromatic region of the 1H NMR spectrum of the cro repressor of the Escherichia coli lysogenic phage lambda.	Hydrogen	94-96	cro	Escherichia virus Lambda	117-120
6293822-0	1982	1H-NMR studies on nucleotide binding to the sarcoplasmic reticulum Ca2+ ATPase.	Hydrogen	0-2	carbonic anhydrase 2	Homo sapiens	67-78
7099981-3	1982	In the present study, secretin and motilin were obtained in 16% and 10% yields, respectively, after simplified two-step purification of hydrogen fluoride-cleaved peptides by gel filtration followed by preparation high performance liquid chromatography.	Hydrogen	136-144	motilin	Canis lupus familiaris	35-42
17842405-0	1982	Internal Hydrogen Bond Formation in a syn-Hydroxyepoxide.	Hydrogen	9-17	synemin	Homo sapiens	38-41
17842405-1	1982	The existence of an internal hydrogen bond in a compound representative of a syn diol epoxide (a possible intermediate in chemical carcinogenesis by certain polycyclic aromatic hydrocarbons) has been demonstrated by x-ray crystallographic and nuclear magnetic resonance studies.	Hydrogen	29-37	synemin	Homo sapiens	77-80
7265224-0	1981	Hydrogen exchange from identified regions of the S-protein component of ribonuclease as a function of temperature, pH, and the binding of S-peptide.	Hydrogen	0-8	vitronectin	Homo sapiens	49-58
7248461-5	1980	The model is simple, has a precedent in the hydrogen exchange literature, and explains quantitatively the complex feature of the exchange kinetics of single protons in BPTI, including the following.	Hydrogen	44-52	spleen trypsin inhibitor I	Bos taurus	168-172
7415408-1	1980	This 1H-NMR study provides experimental evidence for an intermolecular interaction between the dipeptide carnosine (beta-alanyl-L-histidine) and the purine nucleoside 5"-monophosphates 5"-AMP, 5"-GMP.	Hydrogen	5-7	5'-nucleotidase, cytosolic II	Homo sapiens	196-199
6106214-12	1980	This method has also been used to measure isotope exchange (1H-2H) of lactate and of pyruvate at both the C-3 and the C-2 positions, and some of these exchange rates can be interpreted in terms of the activity of specific enzymes in the cells.	Hydrogen	60-62	complement C3	Homo sapiens	106-109
6900508-1	1980	Proton nuclear magnetic resonance (1H NMR) spectra were measured of the polypeptide chain elongation factor Tu (EF-Tu) from an extreme thermophile, Thermus thermophilus HB8 [Nakano, A., Miyazawa, T., Nakamura, S., &amp; Kaziro, Y.	Hydrogen	35-37	elongation factor Tu	Thermus thermophilus HB8	112-117
6900508-7	1980	A hydrogen-deuterium exchange experiment was carried out on the histidine C2 protons of free EF-Tu, and the previous assignments of C2 proton signals were revised in part.	Hydrogen	2-10	elongation factor Tu	Thermus thermophilus HB8	93-98
6900508-8	1980	An analysis of the 1H NMR spectra of EF-Tu photooxidized under various conditions indicates that a histidine residue is located in the aminoacyl-tRNA binding site and is probably essential for the binding with aminoacyl-tRNA.	Hydrogen	19-21	elongation factor Tu	Thermus thermophilus HB8	37-42
6900508-10	1980	Furthermore, the effect of paramagnetic hexacyanochromate(III) ion on the 1H NMR spectra of free EF-Tu suggests that another histidine residue lies near the guanine nucleotide binding site.	Hydrogen	74-76	elongation factor Tu	Thermus thermophilus HB8	97-102
435461-4	1979	The configurational purity of tritium at C-2 of dopamine and C-1 of the dopamine precursor 3-methoxy-4-hydroxyphenethylamine has been confirmed employing dopamine-beta-hydroxylase (specific for the pro-R hydrogen at C-2) and pea seedling amine oxidase (specific for the pro-S hydrogen at C-1).	Hydrogen	204-212	complement C2	Bos taurus	41-44
435461-4	1979	The configurational purity of tritium at C-2 of dopamine and C-1 of the dopamine precursor 3-methoxy-4-hydroxyphenethylamine has been confirmed employing dopamine-beta-hydroxylase (specific for the pro-R hydrogen at C-2) and pea seedling amine oxidase (specific for the pro-S hydrogen at C-1).	Hydrogen	276-284	complement C2	Bos taurus	41-44
220604-5	1979	The effect of a change in hydrogen bond geometry is studied by employing x-ray coordinates for reduced and oxidized cytochrome c, deoxy- and metmyoglobin, and deoxy- and methemoglobin.	Hydrogen	26-34	hemoglobin subunit gamma 2	Homo sapiens	170-183
105760-6	1979	These studies together with alternate substrate studies indicate that nucleoside binding requires a functional group capable of hydrogen bonding at the 6-position of the purine ring and that the orientation of the bound substrate may be syn.	Hydrogen	128-136	synemin	Homo sapiens	237-240
428532-0	1979	A determination of the relative compactness of the Ca2+-binding sites of a Ca2+-binding fragment of troponin-C and parvalbumin using lanthanide-induced 1H NMR shifts.	Hydrogen	152-154	parvalbumin	Homo sapiens	115-126
498062-4	1979	The distinctive bay geometry, with a methyl group opposite to a hydrogen, H(12), peri to another hydrogen, H(11), has a long bond C(13)--C(18) = 1.47(1)A in the bay, and the angular benz-ring is inclined at 16.5 degrees to the mean plane of the anthracene fragment.	Hydrogen	64-72	H1.1 linker histone, cluster member	Homo sapiens	107-112
498062-4	1979	The distinctive bay geometry, with a methyl group opposite to a hydrogen, H(12), peri to another hydrogen, H(11), has a long bond C(13)--C(18) = 1.47(1)A in the bay, and the angular benz-ring is inclined at 16.5 degrees to the mean plane of the anthracene fragment.	Hydrogen	97-105	H1.1 linker histone, cluster member	Homo sapiens	107-112
422323-6	1979	It has been suggested that in the insulin molecule the A21 asparagine participates in salt bridge- and hydrogen bond-forming interactions which are critical in the biological activity of the hormone.	Hydrogen	103-111	LOC105613195	Ovis aries	34-41
708779-2	1978	The conformation of a hexapeptide sequence occurring in tropoelastin is discussed from the results obtained using a combined approach of theoretical conformational energy calculations on HCO-Val-Ala-Prb-Gly-OMe and 1h nmr studies on t-Boc-Val-Ala-Pro-Gly-Val-Gly-OMe  in a dilute solution of methanol.	Hydrogen	215-217	elastin	Homo sapiens	56-68
656448-2	1978	Formation of a quinoid-like structure within the glycyl-pyridoxal phosphate moiety of serine transhydroxymethylase (5,10-methylenetetrahydrofolate: glycine hydroxymethyltransferase, EC 2.1.2.1) is dependent upon the dissociation of the 2-S hydrogen of glycine which in turn requires the presence of tetrahydrofolate or analogs thereof.	Hydrogen	240-248	serine hydroxymethyltransferase 2	Homo sapiens	148-180
344312-7	1978	Hydrogen at C-7 of DAHP was not lost in the cyclization step of the reaction, indicating that the enol formed in phosphate elimination participated directly in an aldolase-type reaction with the carbonyl at C-2.	Hydrogen	0-8	complement C7	Homo sapiens	12-15
20554-1	1977	The hydrogenase activity of the intact cells of a thermophilic hydrogen-oxidizing bacterium Pseudomonas thermophila K-2 was determined using methylene blue; it was several times higher than the rate of hydrogen uptake in the presence of oxygene and carbon dioxide.	Hydrogen	4-12	RBPJ pseudogene 3	Homo sapiens	116-119
20554-1	1977	The hydrogenase activity of the intact cells of a thermophilic hydrogen-oxidizing bacterium Pseudomonas thermophila K-2 was determined using methylene blue; it was several times higher than the rate of hydrogen uptake in the presence of oxygene and carbon dioxide.	Hydrogen	63-71	RBPJ pseudogene 3	Homo sapiens	116-119
557989-2	1977	Gmp(Et)Gmp(EtU forms hydrogen-bonded complexes with the amino acid accepting stem of tRNApheyeast and unfractionated tRNA Escherichia coli under physiological salt conditions at 37 degrees C as determined by equilibrium dialysis.	Hydrogen	21-29	5'-nucleotidase, cytosolic II	Homo sapiens	0-3
557989-2	1977	Gmp(Et)Gmp(EtU forms hydrogen-bonded complexes with the amino acid accepting stem of tRNApheyeast and unfractionated tRNA Escherichia coli under physiological salt conditions at 37 degrees C as determined by equilibrium dialysis.	Hydrogen	21-29	5'-nucleotidase, cytosolic II	Homo sapiens	7-10
828056-4	1976	When 3H was used as a label the ratios were much higher than with 14C labelling indicating that the removal of hydrogen at C-9 or C-11 was the rate-limiting step in the biosynthesis of prostaglandin E2 or prostaglandin D2.	Hydrogen	111-119	complement component C9	Oryctolagus cuniculus	123-126
975043-4	1976	The hydrogen atom on C-3 points directly toward the oxygen atom of another molecule.	Hydrogen	4-12	complement C3	Homo sapiens	21-24
1252443-3	1976	The self-complementary dinucleoside monophosphates CpG and GpC and the complementary mixture GpU + ApC form intermolecular hydrogen-bonded complexes at low temperatures.	Hydrogen	123-131	glycophorin C (Gerbich blood group)	Homo sapiens	59-62
1252430-0	1976	1H nuclear magnetic resonance double resonance study of oxytocin in aqueous solution.	Hydrogen	0-2	oxytocin/neurophysin I prepropeptide	Homo sapiens	56-64
1252430-1	1976	Peptide NH resonances in the 250 MHZ 1H nuclear magnetic resonance (NMR) spectrum of oxytocin in H2O were assigned to specific amino acid residues by the "underwater decoupling" technique (i.e., decoupling from corresponding CalphaH resonances, which are buried beneath the intense water peak).	Hydrogen	37-39	oxytocin/neurophysin I prepropeptide	Homo sapiens	85-93
1252430-11	1976	Exposure to solvent of specific hydrogens of oxytocin in H2O was studied by monitoring intensity changes of solute resonances when the solvent peak was saturated.	Hydrogen	32-41	oxytocin/neurophysin I prepropeptide	Homo sapiens	45-53
1140194-6	1975	The deuterium excess of hydrogens derived from NADPH (at C-3 and C-5) was approximately the same as that of hydrogen derived directly from water (at C-4).	Hydrogen	24-33	complement C3	Rattus norvegicus	57-60
1140194-6	1975	The deuterium excess of hydrogens derived from NADPH (at C-3 and C-5) was approximately the same as that of hydrogen derived directly from water (at C-4).	Hydrogen	24-32	complement C3	Rattus norvegicus	57-60
235531-7	1975	In the reduction of D-glyceraldehyde, catalyzed by aldehyde reductase, the pro-4R "A" hydrogen of NADPH attacks the re face of the carbonyl group.	Hydrogen	86-94	aldo-keto reductase family 1 member A1	Sus scrofa	51-69
17771076-0	1974	Hot hydrogen atoms: initiators of reactions of interest in interstellar chemistry and evolution.	Hydrogen	4-12	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
17771076-1	1974	Photochemically generated hot hydrogen atoms initiate reactions with simple molecular substrates including methane to produce organic alcohols, amines, acids, amino acids, and other compounds.	Hydrogen	30-38	alcohol dehydrogenase iron containing 1	Homo sapiens	1-4
17771076-3	1974	Hot hydrogen atoms may be important initiators of reactions in interstellar space and in planetary atmospheres.	Hydrogen	4-12	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
4336373-0	1972	The effects of pH and temperature on hydrogen transfer in the liver alcohol dehydrogenase mechanism.	Hydrogen	37-45	aldo-keto reductase family 1 member A1	Homo sapiens	68-89
5273889-3	1970	Deamino-oxytocin, in addition to the beta-turn, contains a hydrogen bond involving the amide hydrogen of the tyrosine residue and the peptide carbonyl group of the asparagine residue, resulting in an antiparallel beta-type conformation for the ring component.	Hydrogen	59-67	oxytocin/neurophysin I prepropeptide	Homo sapiens	8-16
5273889-3	1970	Deamino-oxytocin, in addition to the beta-turn, contains a hydrogen bond involving the amide hydrogen of the tyrosine residue and the peptide carbonyl group of the asparagine residue, resulting in an antiparallel beta-type conformation for the ring component.	Hydrogen	93-101	oxytocin/neurophysin I prepropeptide	Homo sapiens	8-16
5343788-0	1969	The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene.	Hydrogen	23-31	placenta associated 8	Homo sapiens	40-44
5343788-3	1969	This result confirms the previous observations on the involvement of a C-15 hydrogen atom in cholesterol biosynthesis.	Hydrogen	76-84	placenta associated 8	Homo sapiens	71-75
14165910-0	1964	HYDROGEN ION EQUILIBRIA OF HUMAN CARBONIC ANHYDRASE B.	Hydrogen	0-8	carbonic anhydrase 2	Homo sapiens	33-53
13970458-11	1963	It is suggested that lipids serve as a framework for the developing keratin structure which acquires permanent stability through hydrogen bonds and disulfide cross-links.	Hydrogen	129-137	keratin	Gallus gallus	68-75
13189874-2	1954	Effect of hydrogen ion concentration on various balances of methemoglobin].	Hydrogen	10-18	hemoglobin subunit gamma 2	Homo sapiens	60-73
33409666-4	2021	Given the ability of 1H MRS to identify and quantify specific molecules with high sensitivity and specificity, its potential utility should be successfully transition from "bench-to-bedside" is tantalizing.	Hydrogen	21-23	MROS	Homo sapiens	24-27
33545599-4	2021	EGCG and GCG interacted with tyrosinase mainly by hydrogen bonding and hydrophobic interactions and induced a looser conformation of tyrosinase.	Hydrogen	50-58	tyrosinase	Homo sapiens	29-39
33647754-7	2021	Several analysis parameters like RMSD, RMSF, Rg, SASA, hydrogen bonds numbers, PCA, and FEL revealed that binding of OHPCBs with hTTR results in the formation of stable hTTR-OHPCBs complexes.	Hydrogen	55-63	transthyretin	Homo sapiens	129-133
33647754-7	2021	Several analysis parameters like RMSD, RMSF, Rg, SASA, hydrogen bonds numbers, PCA, and FEL revealed that binding of OHPCBs with hTTR results in the formation of stable hTTR-OHPCBs complexes.	Hydrogen	55-63	transthyretin	Homo sapiens	169-173
34036787-6	2021	The Ag@NiFe/NF electrode displayed overpotentials as low as 180 and 80 mV for oxygen and hydrogen evolution, respectively, at a current density of 10 mA cm-2, and improvements in the specific activity by ~5x and ~1.5x for the oxygen and hydrogen evolution reaction, respectively, compared to benchmark NiFe hydroxide materials.	Hydrogen	89-97	neurofascin	Homo sapiens	12-14
34036787-6	2021	The Ag@NiFe/NF electrode displayed overpotentials as low as 180 and 80 mV for oxygen and hydrogen evolution, respectively, at a current density of 10 mA cm-2, and improvements in the specific activity by ~5x and ~1.5x for the oxygen and hydrogen evolution reaction, respectively, compared to benchmark NiFe hydroxide materials.	Hydrogen	237-245	neurofascin	Homo sapiens	12-14
33729600-2	2021	H2 C EH2 has a dual role of being a Lewis base and acid with the region of pi-electron accumulation above the carbon atom and the region of pi-electron depletion (pi-hole) above the E atom to participate in the NCX   C E (X = H and Cl) hydrogen/halogen bond and C E   NCY (Y = H, Cl, Li and Na) pi-hole bond, respectively.	Hydrogen	236-244	T cell leukemia homeobox 2	Homo sapiens	211-214
33989435-4	2021	At the KDM4E active site, Glu191, Asn291, and Ser197 form a conserved scaffold that restricts substrate dynamics; substrate binding is also mediated by an out of active site hydrogen-bond between the substrate Ser1 and Tyr178.	Hydrogen	174-182	lysine demethylase 4E	Homo sapiens	7-12
33992001-6	2021	Additionally, hydrogen could markedly inhibit the IR injury by modulating the phosphorylated c-Jun N-terminal kinase (JNK) signaling pathway (P < 0.05).	Hydrogen	14-22	mitogen-activated protein kinase 8	Mus musculus	93-116
33992001-6	2021	Additionally, hydrogen could markedly inhibit the IR injury by modulating the phosphorylated c-Jun N-terminal kinase (JNK) signaling pathway (P < 0.05).	Hydrogen	14-22	mitogen-activated protein kinase 8	Mus musculus	118-121
33992001-7	2021	CONCLUSIONS: Taken together, these results revealed the protective effect of hydrogen gas on hind limb ischemia reperfusion injury on mice by attenuating oxidative stress, impairing ER stress and apoptosis, and its ability to modulate JNK signaling pathway.	Hydrogen	77-85	mitogen-activated protein kinase 8	Mus musculus	235-238
33724811-5	2021	The performance of the present spin-flip BSE formalism is illustrated by computing excited-state energies of the beryllium atom, the hydrogen molecule at various bond lengths, and cyclobutadiene in its rectangular and square-planar geometries.	Hydrogen	133-141	spindlin 1	Homo sapiens	31-35
33963788-2	2021	We have carried out 1H-NMR titration of Cinchona and Maruoka ammonium bromides vs nitro, carbonyl, heterocycles, and N-F containing compounds.	Hydrogen	20-22	neurofascin	Homo sapiens	117-120
33953162-5	2021	Structural and Hydrogen-Deuterium-Exchange mass spectrometry analyses demonstrate antibody interaction with an N-terminal region of CXCR2 that is part of the IL-8 epitope.	Hydrogen	15-23	chemokine (C-X-C motif) receptor 2	Mus musculus	132-137
33885298-5	2021	The cationic iron hydrides are active hydrogenation catalysts only for more reactive carbonyl substrates such as PhCHO, and only when the NH and FeH hydrogens are syn to each other.	Hydrogen	149-158	synemin	Homo sapiens	163-166
33885298-7	2021	Unlike tetraphenylborate, the bromide counterion participates in a hydrogen-bonding interaction with the NH group, which influences the relative stability of the cis,anti and cis,syn isomers.	Hydrogen	67-75	synemin	Homo sapiens	179-182
33852061-0	2021	Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis.	Hydrogen	10-18	interleukin 33	Mus musculus	56-61
33870481-0	2021	1H, 13C and 15N chemical shift assignments of the C-terminal domain of human UDP-Glucuronosyltransferase 2B7 (UGT2B7-C).	Hydrogen	0-2	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	77-108
33870481-0	2021	1H, 13C and 15N chemical shift assignments of the C-terminal domain of human UDP-Glucuronosyltransferase 2B7 (UGT2B7-C).	Hydrogen	0-2	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	110-118
33870481-5	2021	We report 1H, 13C and 15N backbone (> 90%) and side-chain assignments (~ 78% completeness according to CYANA) for the C-terminal domain of UGT2B7 (UGT2B7-C).	Hydrogen	10-12	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	139-145
33870481-5	2021	We report 1H, 13C and 15N backbone (> 90%) and side-chain assignments (~ 78% completeness according to CYANA) for the C-terminal domain of UGT2B7 (UGT2B7-C).	Hydrogen	10-12	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	147-155
33863994-6	2021	Using high-field 7T proton Magnetic resonance spectroscopy (1H-MRS), acute MDD subjects exhibit decreased GABA concentration in visual MT+ which, unlike in healthy subjects, no longer correlates with their visual motion performance, i.e., impaired SI.	Hydrogen	60-62	histamine N-methyltransferase	Homo sapiens	135-137
33684824-10	2021	Docking studies predicted that solvent exposure of the side chains of C9 and C19 would uniquely form hydrogen bonds with Met407 of USP7.	Hydrogen	101-109	ubiquitin specific peptidase 7	Homo sapiens	131-135
33360184-0	2021	IRT1 and ZIP2 were involved in exogenous hydrogen-rich water-reduced cadmium accumulation in Brassica chinensis and Arabidopsis thaliana.	Hydrogen	41-49	iron-regulated transporter 1	Arabidopsis thaliana	0-4
33360184-0	2021	IRT1 and ZIP2 were involved in exogenous hydrogen-rich water-reduced cadmium accumulation in Brassica chinensis and Arabidopsis thaliana.	Hydrogen	41-49	ZRT/IRT-like protein 2	Arabidopsis thaliana	9-13
32178584-6	2021	The analysis of the binding modes of G1 and G10 provides a reference for further development of highly active HDAC6 inhibitors.Abbreviations: DS: Discovery Studio; HBA: hydrogen bond acceptor; HBD: hydrogen bond donor, H: hydrophobic; PAINS: Pan Assay Interference Compounds; R: ring-aromatic; RMSD: Root-mean-square deviation.	Hydrogen	169-177	BUD31 homolog	Homo sapiens	44-47
32178584-6	2021	The analysis of the binding modes of G1 and G10 provides a reference for further development of highly active HDAC6 inhibitors.Abbreviations: DS: Discovery Studio; HBA: hydrogen bond acceptor; HBD: hydrogen bond donor, H: hydrophobic; PAINS: Pan Assay Interference Compounds; R: ring-aromatic; RMSD: Root-mean-square deviation.	Hydrogen	198-206	BUD31 homolog	Homo sapiens	44-47
33550182-5	2021	Molecular docking suggested that 6u formed direct hydrogen bond interactions with Ser75 and Gln61 in PDK1, and meanwhile the aniline skeleton in 6u was sandwiched by the conserved hydrophobic residues Phe78 and Phe65, which contribute to the biochemical activity improvement.	Hydrogen	50-58	pyruvate dehydrogenase kinase 1	Homo sapiens	101-105
33704440-8	2021	Structure modelling suggests that by introducing stabilizing hydrogen bonds the mutations slow the kinetics of the channel gate and cause the gain-of-function effect in CaV3.3 channels.	Hydrogen	61-69	calcium voltage-gated channel subunit alpha1 I	Homo sapiens	169-175
33599637-2	2021	A comparative study of 1H and 13C DNP in model systems shows the impact of the spin density distribution and accessibility of the radical site by the target molecule.	Hydrogen	23-25	spindlin 1	Homo sapiens	79-83
33608571-3	2021	We employed differential hydrogen-deuterium exchange mass spectrometry (HDX-MS) and nuclear magnetic resonance (NMR) to characterize the interactions of the IGF1R ectodomain with a recently discovered BBB-crossing single-domain antibody (sdAb), VHH-IR5, in comparison with IGF-1 binding.	Hydrogen	25-33	insulin like growth factor 1 receptor	Homo sapiens	157-162
12007475-3	2002	1H NMR studies of these modified polysaccharides show that the neighboring sulfate groups at the C-2 and C-3 positions might have caused the conformational changes of each monosaccharide from 4C(1) to 1C(4).	Hydrogen	0-2	complement C2	Homo sapiens	97-100
11934523-6	2002	When normalized against bovine GAPDH as an internal control, 0.5 or 1h treatment with 10 ng/mL insulin gave 39+/-4 and 64+/-2-fold increase in leptin mRNA compared with 0 h control.	Hydrogen	68-70	insulin	Bos taurus	95-102
11934523-7	2002	Leptin mRNA was increased 257+/-9 and 75+/-23-fold by 0.5 or 1h treatment with 10 ng/mL IGF-I.	Hydrogen	61-63	insulin like growth factor 1	Bos taurus	88-93
11942842-7	2002	The resulting methyl radical is rapidly quenched by hydrogen-atom transfer from the CoB thiol group, yielding the methane molecule and the CoB radical.	Hydrogen	52-60	metabolism of cobalamin associated B	Homo sapiens	84-87
11942842-7	2002	The resulting methyl radical is rapidly quenched by hydrogen-atom transfer from the CoB thiol group, yielding the methane molecule and the CoB radical.	Hydrogen	52-60	metabolism of cobalamin associated B	Homo sapiens	139-142
24706511-0	2014	Light-Harvesting Complex Protein LHCBM9 Is Critical for Photosystem II Activity and Hydrogen Production in Chlamydomonas reinhardtii.	Hydrogen	84-92	uncharacterized protein	Chlamydomonas reinhardtii	33-39
11751914-8	2002	The modeled structures of the WW domains of PinA and SspI revealed that the structure and the network of hydrogen bonds of Loop I, which are also formed in Pin1 and Y110, are conserved.	Hydrogen	105-113	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	156-160
11866609-0	2002	Hydrogen and higher shell contributions in Zn2+, Ni2+, and Co2+ aqueous solutions: an X-ray absorption fine structure and molecular dynamics study.	Hydrogen	0-8	complement C2	Homo sapiens	59-62
11866610-5	2002	This procedure has been successfully applied to the Co2+-H2O open-shell system and, for the first time, Co-oxygen and Co-hydrogen pair potential functions have been determined and employed in MD simulations.	Hydrogen	121-129	complement C2	Homo sapiens	52-55
11741948-11	2002	By placing DEA into the active site of the open structure, the major forces to stabilize the closed conformation of AdoHcyase are identified as the hydrogen bonds between the backbone of His-352 and the adenine ring, and the C3"-H...C4 interaction.	Hydrogen	148-156	adenosylhomocysteinase	Homo sapiens	116-125
11831896-10	2002	The ligands phorbol 13-acetate, benzolactam, and ILV are recognized by C1-RasGRP through a number of hydrogen bonds with loops A and B.	Hydrogen	101-109	RAS guanyl releasing protein 1	Homo sapiens	74-80
11831896-11	2002	In the models of C1-RasGRP in complex with phorbol 13-acetate, benzolactam, and ILV, common hydrogen bonds are formed with two residues Thr12 and Leu21, whereas other hydrogen bond interactions are unique for each ligand.	Hydrogen	92-100	RAS guanyl releasing protein 1	Homo sapiens	20-26
11831896-11	2002	In the models of C1-RasGRP in complex with phorbol 13-acetate, benzolactam, and ILV, common hydrogen bonds are formed with two residues Thr12 and Leu21, whereas other hydrogen bond interactions are unique for each ligand.	Hydrogen	167-175	RAS guanyl releasing protein 1	Homo sapiens	20-26
11754578-3	2002	In the case of MAC DHFR inhibitors, the best pharmacophore in terms of statistics and predictive value consisted of four features: two hydrogen bond acceptors (HA), one hydrophobic (HY) feature, and one ring aromatic (RA) feature.	Hydrogen	135-143	dihydrofolate reductase	Homo sapiens	19-23
12751909-2	2002	It is found that selective CYP2F2 substrates are able to fit the putative active site of the enzyme via aromatic pi-pi stacking and, in some cases, hydrogen-bonded interactions.	Hydrogen	148-156	cytochrome P450, family 2, subfamily f, polypeptide 2	Mus musculus	27-33
12408104-6	2002	As with rhodopsin, conformational signaling appears to depend on the rearrangement of key electrostatic, hydrogen-bond, and hydrophobic interactions that normally serve to stabilize the inactive LHR conformation.	Hydrogen	105-113	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	195-198
11602601-5	2001	Furthermore, correlation of the selectivity characteristics of the SGLT isoforms (SGLT1 transports both glucose and galactose, but SGLT2 and SGLT3 transport only glucose) with amino acid sequence differences, suggests that residue 460 (threonine in SGLT1, and serine in SGLT2 and SGLT3) are involved in hydrogen bonding to O4 of the pyranose.	Hydrogen	303-311	solute carrier family 5 member 4	Homo sapiens	141-146
11714605-3	2001	Substitution of the ethanolamine nitrogen with a benzyl group bearing a para hydrogen bond acceptor promoted beta(3) selectivity.	Hydrogen	77-85	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	109-116
12404416-0	2001	Combined Effects of Metal and Ligand Capable of Accepting a Proton or Hydrogen Bond Catalyze Anti-Markovnikov Hydration of Terminal Alkynes The support of San Diego State University is acknowledged.	Hydrogen	70-78	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	155-158
12166824-0	2001	Effect of hydrogen ion concentration and buffer composition on ligand binding characteristics and polymerization of cow"s milk folate binding protein.	Hydrogen	10-18	folate receptor alpha	Bos taurus	122-149
12166824-1	2001	The ligand binding and aggregation behavior of cow"s milk folate binding protein depends on hydrogen ion concentration and buffer composition.	Hydrogen	92-100	folate receptor alpha	Bos taurus	53-80
11766754-6	2001	The [RGD + 2Cs - H]+ species exhibit the slowest H/D exchange reactivity (reaction rate constant of approximately 6 x 10(-13) cm3molecule(-1)s(-1) for the fastest exchanging labile hydrogen with ND3).	Hydrogen	181-189	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	195-198
11695903-6	2001	Furthermore, hydrogen bonds of residues 67-72 belonging to beta5 are substantially weakened or partially broken, giving increased freedom of motion for the C-terminal segment.	Hydrogen	13-21	adaptor related protein complex 5 subunit beta 1	Homo sapiens	59-64
11710007-5	2001	The optimum conditions for phthalimido group deprotection are studied to generate a unique product with a hydrophobic chain attached mainly at the hydroxyl group (C-6 and/or C-3) while the amino group (C-2) is retained as characterized by FT-IR and 1H NMR.	Hydrogen	249-251	complement C2	Homo sapiens	202-205
11513578-7	2001	The interactions between Rac1 and RhoGDI occur through hydrogen bonds which involve a number of residues of Rac1, namely, Tyr64(Rac), Arg66(Rac), His103(Rac), and His104(Rac), conserved within the Rho family and localized in the switch II region or in its close neighborhood.	Hydrogen	55-63	Rho GDP dissociation inhibitor alpha	Homo sapiens	34-40
33378203-3	2021	A 1:1 binding stoichiometry between Au(CN)2- and alpha-cyclodextrin in aqueous solution, revealed by 1H NMR titrations, has produced binding constants in the order of 104 M-1.	Hydrogen	101-103	carnosine dipeptidase 2	Homo sapiens	36-43
33289903-7	2021	The model highlighted the importance of the presence of hydrogen bonding acceptor groups on specific positions of the aromatic ring of ascofuranone derivatives, acidity of the compounds, and a large linker group on the compounds on the inhibitory effect of AOX.	Hydrogen	56-64	acyl-CoA oxidase 1	Homo sapiens	257-260
33502009-7	2021	Molecular docking showed that resveratrol had hydrogen bonding interactions with Kelch-like ECH associated protein 1 (Keap1), a repressor protein of the classic antioxidant Keap1-Nrf2 pathway.	Hydrogen	46-54	kelch-like ECH-associated protein 1	Mus musculus	81-116
33502009-7	2021	Molecular docking showed that resveratrol had hydrogen bonding interactions with Kelch-like ECH associated protein 1 (Keap1), a repressor protein of the classic antioxidant Keap1-Nrf2 pathway.	Hydrogen	46-54	kelch-like ECH-associated protein 1	Mus musculus	118-123
31068026-0	2021	Correlations of PPARalpha and PPARgamma expressions with 1H-MRS quantified hepatic fat content in pups of rats that experienced intrauterine growth restriction.	Hydrogen	57-59	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	30-39
31068026-2	2021	This study was to explore the association of peroxisome proliferator-activated receptor alpha and gamma (PPARalpha and PPARgamma) expression with 1H-MRS quantified hepatic fat content in offspring of rats that experienced intrauterine growth restriction (IUGR).	Hydrogen	146-148	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	119-128
32970293-4	2021	The most potent inhibitor was a 1-tetralone derivative (1h) with IC50 values of 0.036 and 0.0011 microM for MAO-A and MAO-B, respectively.	Hydrogen	56-58	monoamine oxidase B	Homo sapiens	118-123
33103784-4	2021	The addition of hydrogen-rich water and expression of the hydrogenase1 gene (CrHYD1) from Chlamydomonas reinhardtii increased endogenous H2 and MT levels, and enhanced salinity tolerance.	Hydrogen	16-24	uncharacterized protein	Chlamydomonas reinhardtii	77-83
33603945-0	2021	Corrigendum to "Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats".	Hydrogen	16-24	heme oxygenase 1	Rattus norvegicus	97-101
33346754-0	2021	Metallic and anti-metallic properties of hydrogen adsorbed AnO2 (An = Th, U, and Pu) surfaces.	Hydrogen	41-49	anoctamin 2	Homo sapiens	59-63
33346754-1	2021	The effect of atomic hydrogen adsorption on AnO2 (An = Th, U, and Pu) surfaces is studied in the framework of density functional theory and Hubbard-corrected density functional theory.	Hydrogen	21-29	anoctamin 2	Homo sapiens	44-48
33398988-6	2021	Moreover, a single binding site was predicted for AtGPX6 toward dinotefuran, and the complex formation was presumed to be driven by hydrogen bonds or van der Waals forces, which conformed with the molecular docking results.	Hydrogen	132-140	glutathione peroxidase 6	Arabidopsis thaliana	50-56
32706524-7	2021	Here we discuss in detail two distinct examples, namely the conserved catalytic triad and the photoreceptor, photoactive yellow protein, where studies of these SHB-containing systems have permitted contextualization of the role these unique hydrogen bonds play in biology.	Hydrogen	241-249	SH2 domain containing adaptor protein B	Homo sapiens	160-163
33049448-8	2021	Taking the number of hydrogen bonds and ZDock scores into account, the rank of docking ability between RXRalpha and the NRs was PXR > TRbeta > PPARgamma.	Hydrogen	21-29	retinoid X receptor alpha	Homo sapiens	103-111
33310290-11	2021	Western blotting was carried out and confirmed the ability of compound 1h to inhibit VEGFR2 kinase inside Hep-G2 HCC cells in a dose-dependent pattern.	Hydrogen	71-73	kinase insert domain receptor	Homo sapiens	85-91
33397109-3	2021	These collision adducts undergo a nonstatistical unimolecular decomposition through atomic hydrogen elimination to at least the cyclic 1-vinyl-cyclopropene (p5/p26), 1-methyl-3-methylenecyclopropene (p28), and 1,2-bis(methylene)cyclopropane (p29) in overall exoergic reactions.	Hydrogen	91-99	golgi SNAP receptor complex member 1	Homo sapiens	200-203
32219872-10	2021	In conclusion, H2 S-mediated Keap1 S-sulfhydration alleviates liver damage via activation of Nrf2.	Hydrogen	15-17	kelch-like ECH-associated protein 1	Mus musculus	29-34
32958393-7	2021	Inner membrane (IM) quinones (i.e., ubiquinone and menaquinone), IM quinone-reactive hydrogenase Hya, and IM-bound quinone reductase CymA are involved in hydrogen-dependent current generation, suggesting that the redox cycling of IM quinones catalyzed by Hya and CymA contributes to the generation of the proton motive force and the synthesis of ATP via F0F1-ATPase.	Hydrogen	85-93	cytochrome c	Shewanella oneidensis MR-1	263-267
33212396-5	2021	These approaches allow for identifying key factors for Ga3+ beneficial effect such as the electrostatic interactions with the protein ligands, substrates or bacterial siderophores, intramolecular hydrogen bond formation, and pH and dielectric properties of the medium.	Hydrogen	196-204	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	55-58
33227675-5	2021	1H-detected 2D 1H/13C SSNMR for the GB1 sample indicated the effectiveness of this approach in various multidimensional applications.	Hydrogen	0-2	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	36-39
33227675-5	2021	1H-detected 2D 1H/13C SSNMR for the GB1 sample indicated the effectiveness of this approach in various multidimensional applications.	Hydrogen	15-17	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	36-39
32484077-17	2021	The 1D 1H-15N CP (Cross polarization) solid-state NMR spectra suggest that the wt/m-hMC4R-TM2 undergo rotational diffusion around a perpendicular axis along the bilayer normal.	Hydrogen	7-9	melanocortin 4 receptor	Homo sapiens	84-89
33086111-1	2020	Composite polycaprolactone-chitosan material was produced by an electrospinning method and used as a support for immobilization of tyrosinase by mixed ionic interactions and hydrogen bonds formation.	Hydrogen	174-182	tyrosinase	Homo sapiens	131-141
33211494-2	2020	The monoclinic structure, recently solved by X-ray single-crystal diffraction at 100(2) K, is built up by tetramers (HN3)4 in unique pseudotetragonal layers with N-H   N hydrogen bonds, but with only weak van der Waals bonds between them.	Hydrogen	170-178	MT-RNR2 like 3 (pseudogene)	Homo sapiens	117-120
33265924-8	2020	Using pairwise comparison with the Kruskal-Wallis test to associate the area under the curve (AUC) of LIT patients and, LIT with HIT, to LIT with HIT and FM it was found, that the exhaled hydrogen values were significantly higher in patients with two-fold and triple combined food intolerance/malabsorption (p < 0.004 and p < 0.001, respectively).	Hydrogen	188-196	fibromodulin	Homo sapiens	154-156
33084670-6	2020	It was interesting to note that DES1 possessing urea as a hydrogen bond donor leads to the exceptional thermal stability of the BSA structure.	Hydrogen	58-66	delta 4-desaturase, sphingolipid 1	Homo sapiens	32-36
33085886-1	2020	Carbothermal hydrogen reduction (CHR) is a unique dry chemical process used to fabricate metals and carbides on carbon supports.	Hydrogen	13-21	chromate resistance; sulfate transport	Homo sapiens	33-36
32473601-5	2020	Intriguingly, molecular modeling elucidated that three compounds competitively bind to tyrosinase mainly through more interactions with Cu2+ ions and the amino acid residue capable of forming cation-pi and hydrogen bonding, forming a reversible non-covalent complex.	Hydrogen	206-214	tyrosinase	Homo sapiens	87-97
33096664-10	2020	However, molecular dynamics simulations demonstrated that only ZINC16525481 and ZINC38484632 which have good binding free energy and stable hydrogen bonding interactions with EGFR and VEGFR2.	Hydrogen	140-148	kinase insert domain receptor	Homo sapiens	184-190
24706511-6	2014	Knockdown cell lines with 50 to 70% reduced amounts of LHCBM9 showed reduced photosynthetic activity upon illumination and severe perturbation of hydrogen production activity.	Hydrogen	146-154	uncharacterized protein	Chlamydomonas reinhardtii	55-61
33066693-8	2020	In this complex, isatin is targeted to the interface of interacting FECH and ADR monomers, forming hydrogen bonds with both FECH and ADR.	Hydrogen	99-107	ferrochelatase	Homo sapiens	68-72
33066693-8	2020	In this complex, isatin is targeted to the interface of interacting FECH and ADR monomers, forming hydrogen bonds with both FECH and ADR.	Hydrogen	99-107	ferrochelatase	Homo sapiens	124-128
24512177-4	2014	In previous work, a hydrogen exchange mass spectrometry (HX MS) platform was developed to study the structural configuration of GGCX in a near-native nanodisc phospholipid environment.	Hydrogen	20-28	gamma-glutamyl carboxylase	Homo sapiens	128-132
32897695-4	2020	Molecular modeling revealed that water-mediated hydrogen-bond formation between 3-OH of nalfurafine and KOR accounted for its higher KOR potency than 42B.	Hydrogen	48-56	opioid receptor, kappa 1	Mus musculus	104-107
32897695-4	2020	Molecular modeling revealed that water-mediated hydrogen-bond formation between 3-OH of nalfurafine and KOR accounted for its higher KOR potency than 42B.	Hydrogen	48-56	opioid receptor, kappa 1	Mus musculus	133-136
24445986-2	2014	For anilines and carbazoles the reaction proceeds by the liberation of H2 as the sole Si-N coupling byproduct.	Hydrogen	71-73	embryonal Fyn-associated substrate	Homo sapiens	86-90
32436056-2	2020	1-28-Rv0603 displayed good peak yield and signal dispersion in 2D [15N-1H] HSQC spectrum, which prompted us to proceed for resonance assignments on this construct.	Hydrogen	71-73	hypothetical protein	Mycobacterium tuberculosis H37Rv	5-11
24842017-6	2014	V-ATPase activity, activities of secreted MMP-2 and MMP-9 and extracellular hydrogen ion concentration were significantly increased in LASS2/TMSG1-shRNA group compared with the control group (P&lt;0.05).	Hydrogen	76-84	ceramide synthase 2	Homo sapiens	135-140
32557393-0	2020	1H, 13C, and 15N backbone assignments of the C-terminal region of the human retinoic acid-induced protein 2.	Hydrogen	0-2	retinoic acid induced 2	Homo sapiens	76-107
32557393-4	2020	Structurally, RAI2 remains an unknown entity and, hence, to obtain a detailed view on the structure function relationship we report the 1H, 13C, and 15N resonance assignments for the backbone and side chain nuclei of the C-terminal region (a.a. 303-451 of UniProt Q9Y5P3) of RAI2.	Hydrogen	136-138	retinoic acid induced 2	Homo sapiens	14-18
32583165-0	2020	1H, 13C and 15N backbone resonance assignment of BRCA1 fragment 219-504.	Hydrogen	0-2	BRCA1 DNA repair associated	Homo sapiens	49-54
32583165-3	2020	Here were report 1H, 13C, and 15N resonance assignments for the intrinsically disordered BRCA1 fragment 219-504, which contains important interaction sites for the proto-oncogenic transcription factor MYC as well as for p53.	Hydrogen	17-19	BRCA1 DNA repair associated	Homo sapiens	89-94
24394922-0	2014	Three-dimensional MoS2-CdS-gamma-TaON hollow composites for enhanced visible-light-driven hydrogen evolution.	Hydrogen	90-98	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
32693297-4	2020	Both isomers were treated with l-cysteine as nucleophilic thiol source and only the anti-isomer shows dissociation of one bisimidazolylidene ligand after 24 h. In the case of the syn-isomer, density functional theory calculations indicate a lower reactivity due to the higher steric hindrance of the N-substituents and additional hydrogen bond interaction, which prevents a nucleophilic attack.	Hydrogen	330-338	synemin	Homo sapiens	179-182
24394922-2	2014	Even without the noble-metal cocatalyst, the as-prepared MoS2-CdS-gamma-TaON hollow structure with 1 wt% MoS2/CdS cocatalyst (0.2 wt% MoS2) decorated on its surface produces a high photocatalytic hydrogen production rate of 628.5 mumol h(-1).	Hydrogen	196-204	CDP-diacylglycerol synthase 1	Homo sapiens	62-65
24552877-6	2014	However, large differences are found in helices E and F. The hydrophobic contacts and hydrogen bonds between helices E and G in apo-14-3-3sigma are different from those in the bound 14-3-3sigma complex.	Hydrogen	86-94	stratifin	Homo sapiens	132-143
32936152-3	2020	For cationic reverse micelles, we find that the absorption at frequencies >2500 cm-1 is dominated by asymmetric proton-hydration structures in which one of the OH groups of H3O+ is more weakly hydrogen-bonded to water than the other two OH groups.	Hydrogen	193-201	H3 clustered histone 15	Homo sapiens	173-176
24431148-1	2014	Protonated pyridyl-substituted tetrathiafulvalene electron-donor molecules (PyH(+)-TTF) showed significant changes in the electron-donating ability and HOMO-LUMO energy gap compared to the neutral analogues and gave a unique N(+)-H   N hydrogen-bonded (H-bonded) dimer unit in the proton-electron correlated charge-transfer (CT) complex crystals.	Hydrogen	236-244	ras homolog family member H	Homo sapiens	83-86
32978402-4	2020	The unique up-field 1H-NMR chemical shift and the highly efficient incorporation of TMSiPhe enabled the characterization of multiple conformational states of a phospho-beta2 adrenergic receptor/beta-arrestin-1(beta-arr1) membrane protein signaling complex, using only 5 muM protein and 20 min of spectrum accumulation time.	Hydrogen	20-22	adrenoceptor beta 2	Homo sapiens	168-193
32963245-4	2020	Synapsis is mediated solely by Polmu, facilitated by single-nucleotide homology at the break site, wherein both ends of the discontinuous template strand are stabilized by a hydrogen bonding network.	Hydrogen	174-182	DNA polymerase mu	Homo sapiens	31-36
24435565-8	2014	Signals of many residues including tyrosines in both phosphorylated and unmodified forms of CD79b are found in a heavily crowded region of 2D 1H-15N correlation spectrum and the significantly enhanced spectral resolution provided by the 3D time-resolved approach was essential for the quantitative site-specific analysis.	Hydrogen	142-144	CD79b molecule	Homo sapiens	92-97
32588927-2	2020	These pseudo-anomeric effects are apparent when electronegative CF 2 groups are placed at the C-2, C-4 and C-6 positions of the cyclohexane ring to render the C-3/5 axial hydrogens electropositive.	Hydrogen	171-180	complement C3	Homo sapiens	159-162
32974937-3	2020	The large extracellular domain (EC2) of CD53 protrudes away from the membrane surface and exposes a variable region, which is identified by hydrogen-deuterium exchange as the common interface for CD53 and CD81 to bind partners.	Hydrogen	140-148	CD53 molecule	Homo sapiens	40-44
32974937-3	2020	The large extracellular domain (EC2) of CD53 protrudes away from the membrane surface and exposes a variable region, which is identified by hydrogen-deuterium exchange as the common interface for CD53 and CD81 to bind partners.	Hydrogen	140-148	CD53 molecule	Homo sapiens	196-200
32974937-3	2020	The large extracellular domain (EC2) of CD53 protrudes away from the membrane surface and exposes a variable region, which is identified by hydrogen-deuterium exchange as the common interface for CD53 and CD81 to bind partners.	Hydrogen	140-148	CD81 molecule	Homo sapiens	205-209
32933292-1	2020	The self-diffusion coefficient of water shows an anomalous increase with increasing hydrostatic pressure up to a broad maximum (PmD) near 1 kbar at 298 K, which has been attributed to pressure effects on the tetrahedral hydrogen bond network of water.	Hydrogen	220-228	proteolipid protein 1	Homo sapiens	128-131
11504875-2	2001	We found that despite the reduced capability of DMA in forming hydrogen bonds, N(omega),N(omega)-dimethylation does not affect the strength of the binding to nucleic acids nor does it have any effect on stabilization of a double-stranded DNA substrate.	Hydrogen	63-71	major histocompatibility complex, class II, DM alpha	Homo sapiens	48-51
11313338-0	2001	1H NMR study on the binding of Pin1 Trp-Trp domain with phosphothreonine peptides.	Hydrogen	0-2	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	31-35
32933292-6	2020	Results suggest that the initial increasing diffusion with pressure is because hydrogen bonds are distorted and thus weakened by pressure, but above PmD, the hydrogen bonds are weakened to the point it behaves more like a normal liquid.	Hydrogen	158-166	proteolipid protein 1	Homo sapiens	149-152
24392650-4	2014	The anion binding experiments revealed interesting difference in the binding mode: The cis-1 isomer binds anions in a mixed binding mode featuring a combination of hydrogen bonding and anion-pi interactions resulting in an unexpected strong binding.	Hydrogen	164-172	suppressor of cytokine signaling 1	Homo sapiens	87-92
32933292-7	2020	In other words, the PmD may be a measure of the angular strength of hydrogen bonds.	Hydrogen	68-76	proteolipid protein 1	Homo sapiens	20-23
24364692-0	2014	Ultrafast hydrogen exchange reveals specific structural events during the initial stages of folding of cytochrome c.	Hydrogen	10-18	cytochrome c, somatic	Equus caballus	103-115
32787281-11	2020	It is consistent with the observed differential 1H spin-lattice relaxation of Nif and PVP as well as a domain structure on the 20-nm scale observed in AFM images.	Hydrogen	48-50	S100 calcium binding protein A9	Homo sapiens	78-81
32687357-1	2020	Although the N-H bond in peptide backbones is stronger than the C-H bond, hydrogen abstraction from the amide nitrogen is considered to be the initial step in the Calpha-C bond cleavage of peptide backbones by matrix-assisted laser desorption/ionization in-source decay (MALDI-ISD) when using an oxidizing matrix.	Hydrogen	74-82	carbonic anhydrase 2	Homo sapiens	163-171
11495251-0	2001	1H, 13C and 15N chemical shift assignment of the honeybee pheromone carrier protein ASP1.	Hydrogen	0-2	odorant binding protein 1	Apis mellifera	84-88
11430760-0	2001	1H, 15N and 13C resonance assignments for the Tctex1 dynein light chain from Chlamydomonas flagella.	Hydrogen	0-2	dynein light chain Tctex-type 1	Homo sapiens	46-52
25756669-6	2014	We establish that the physicochemical parameters critical for DPP4 inhibitory activity are: hydrophobicity described by the logarithm of the octanol/water partition coefficient, counts of rotatable bonds, hydrogen bond donor and acceptor atoms, and topological polar surface area.	Hydrogen	205-213	dipeptidyl peptidase 4	Homo sapiens	62-66
11261970-10	2001	Variable-temperature 31P[1H] NMR studies on the allyl complexes show that the eta3/eta1 allyl interconversion is enhanced by a positive charge and also by a N-H.Cl intramolecular interaction.	Hydrogen	25-27	secreted phosphoprotein 1	Homo sapiens	83-87
32701600-5	2020	Reabsorption of about 66% of sodium is accomplished in the proximal tubule and dependent on the sodium-hydrogen exchanger isoform 3 (NHE3).	Hydrogen	103-111	solute carrier family 9 member A3	Homo sapiens	133-137
24987428-7	2014	The docking poses, hydrogen bond variation, and hydrophobic interactions found Asp103 and Lys106 are crucial to IKK2 binding areas for IKK2 inhibition.	Hydrogen	19-27	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	112-116
32634569-9	2020	Fourier transform infrared (FTIR) spectra revealed that the existence of hydrogen bonding between the drug and surfactant after neutralization, attributed to NSP size reduction.	Hydrogen	73-81	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	158-161
11300900-7	2001	The transfer of the hydrogen and the connection between C-2 and C-5" might be the driving force of dimerization.	Hydrogen	20-28	complement C2	Homo sapiens	56-59
11300900-7	2001	The transfer of the hydrogen and the connection between C-2 and C-5" might be the driving force of dimerization.	Hydrogen	20-28	complement C5	Homo sapiens	64-67
24987428-7	2014	The docking poses, hydrogen bond variation, and hydrophobic interactions found Asp103 and Lys106 are crucial to IKK2 binding areas for IKK2 inhibition.	Hydrogen	19-27	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	135-139
32659072-6	2020	X-ray crystal structures of this HDAC10 variant complexed with Tubastatin A and indole analogues bearing pendant tertiary amines reveal that inhibitors capable of hydrogen bonding with gatekeeper E274 exhibit high affinity and selectivity for HDAC10 over HDAC6 (the other class IIb isozyme).	Hydrogen	163-171	histone deacetylase 10	Homo sapiens	33-39
25415460-0	2014	X-ray absorption spectroscopy with time-tagged photon counting: application to study the structure of a Co(i) intermediate of H2 evolving photo-catalyst.	Hydrogen	126-128	COX1	Dipturus trachyderma	104-108
32659072-6	2020	X-ray crystal structures of this HDAC10 variant complexed with Tubastatin A and indole analogues bearing pendant tertiary amines reveal that inhibitors capable of hydrogen bonding with gatekeeper E274 exhibit high affinity and selectivity for HDAC10 over HDAC6 (the other class IIb isozyme).	Hydrogen	163-171	histone deacetylase 10	Homo sapiens	243-249
11178915-1	2001	The kinetics of solvent accessibility at the protein-protein interface between thrombin and a fragment of thrombomodulin, TMEGF45, have been monitored by amide hydrogen/deuterium (H/2H) exchange detected by MALDI-TOF mass spectrometry.	Hydrogen	160-168	thrombomodulin	Homo sapiens	106-120
11933244-1	2001	We have studied the stereospecificities of various pyridoxal 5"-phosphate dependent enzymes for the hydrogen transfer between the C-4" of a bound coenzyme and the C-2 of a substrate in the transamination catalyzed by the enzymes.	Hydrogen	100-108	complement C4A (Rodgers blood group)	Homo sapiens	130-133
11933244-1	2001	We have studied the stereospecificities of various pyridoxal 5"-phosphate dependent enzymes for the hydrogen transfer between the C-4" of a bound coenzyme and the C-2 of a substrate in the transamination catalyzed by the enzymes.	Hydrogen	100-108	complement C2	Homo sapiens	163-166
24000822-5	2014	The inhibitor was stabilized by hydrogen bonding interactions with residues Arg 145, Asn 566, Pro 731 and His 732 of hECE-1.	Hydrogen	32-40	endothelin converting enzyme 1	Homo sapiens	117-123
11511808-7	2000	In addition, NMR evidence points to the formation of hydrogen bonds between the peptide backbone NH protons and the proximal GalNAc groups in the (Ser.Tn)3 and (Ser.STn)3 trimers.	Hydrogen	53-61	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	165-168
32722909-3	2020	Recently, we showed that a 1h pre-treatment with anti-angiogenic drugs prior to ultra-high single dose radiotherapy and specific chemotherapies transiently de-represses acid sphingomyelinase (ASMase), leading to enhanced cancer therapy-induced, ceramide-mediated vascular injury and tumor response.	Hydrogen	27-29	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	169-190
32722909-3	2020	Recently, we showed that a 1h pre-treatment with anti-angiogenic drugs prior to ultra-high single dose radiotherapy and specific chemotherapies transiently de-represses acid sphingomyelinase (ASMase), leading to enhanced cancer therapy-induced, ceramide-mediated vascular injury and tumor response.	Hydrogen	27-29	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	192-198
32718063-4	2020	The thermodynamic analysis suggested the existence of multiple contact types, such as Van der Waals" force and hydrogen bonds, between beta-LG and CA.	Hydrogen	111-119	beta-lactoglobulin	Bos taurus	135-142
24759528-8	2014	The results showed that the yield of hydrogen with CdS/TNTs + WO3 was much higher than with CdS/TiO2 + WO3.	Hydrogen	37-45	CDP-diacylglycerol synthase 1	Homo sapiens	51-54
32717970-5	2020	Our study revealed that the spin polarization on hydrogens decreases with longer distances from the nitrile group, and its maximum polarization is found to be approximately 70 G with 5 muL of substrates in all structures.	Hydrogen	49-58	spindlin 1	Homo sapiens	28-32
32618986-4	2020	For an anti-MCI, the dominant channel starting from the S1 state is the ring-closure process leading to dioxirane, while in the syn configuration, the intramolecular CHO hydrogen bond hinders the rotation around the C-O bond and thus leads to a high yield of in-plane O-O dissociation towards acetaldehyde (X1A") and the O(1D) atom.	Hydrogen	170-178	synemin	Homo sapiens	128-131
24759528-8	2014	The results showed that the yield of hydrogen with CdS/TNTs + WO3 was much higher than with CdS/TiO2 + WO3.	Hydrogen	37-45	CDP-diacylglycerol synthase 1	Homo sapiens	92-95
11154562-2	2000	Under these conditions rate-determining Co-C heterolytic cleavage is preceded by rapid addition of cyanide to AdoCbl to form an intermediate, (beta-5"-deoxyadenosyl)(alpha-cyano)cobalamin ((beta-Ado)(alpha-CN)Cbl-), identified by 1H NMR spectroscopy.	Hydrogen	230-232	Cbl proto-oncogene	Homo sapiens	113-116
24329062-0	2013	A new ab initio potential energy surface for the collisional excitation of HCN by para- and ortho-H2.	Hydrogen	98-100	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	75-78
11086893-5	2000	The spatial orientations of hydrogen-bonded water molecules were found to be of a linear type with a triple-layer structure in the HA region and HA part (in the MIX region), and double-layer structures in the HD region and HD part (in the MIX region).	Hydrogen	28-36	Mix paired-like homeobox	Homo sapiens	161-164
11086893-5	2000	The spatial orientations of hydrogen-bonded water molecules were found to be of a linear type with a triple-layer structure in the HA region and HA part (in the MIX region), and double-layer structures in the HD region and HD part (in the MIX region).	Hydrogen	28-36	Mix paired-like homeobox	Homo sapiens	239-242
32650607-6	2020	The molecular docking results exhibited that the small molecule 13b is well accommodated by the bound region of Kelch-like ECH-associated protein 1 (Keap1)-Kelch and NRF2 through stable hydrogen bonds and hydrophobic interaction, which contributed to the enhancement of affinity and stability between the ligand and receptor.	Hydrogen	186-194	kelch like family member 2	Homo sapiens	112-117
32630113-6	2020	Furthermore, molecular docking analysis showed that peptides ELKDLKGY and ILDKVGINY could form hydrogen bonds, pi-cation interactions, and salt bridges with DPP-IV.	Hydrogen	95-103	dipeptidyl peptidase 4	Bos taurus	157-163
11086893-7	2000	From the difference SDF (DSDF), deltagoo(x,y, z), between the SDFs of two conformations, we concluded that the distribution of hydration water molecules in the HA and HD parts of the MIX region are governed by the competition of internal hydrogen bonds between the hydrogen atom and two lone-pair electrons on the oxygen atom of an EG molecule.	Hydrogen	238-246	Mix paired-like homeobox	Homo sapiens	183-186
24329062-1	2013	We present a new four-dimensional potential energy surface for the collisional excitation of HCN by H2.	Hydrogen	100-102	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	93-96
11086893-7	2000	From the difference SDF (DSDF), deltagoo(x,y, z), between the SDFs of two conformations, we concluded that the distribution of hydration water molecules in the HA and HD parts of the MIX region are governed by the competition of internal hydrogen bonds between the hydrogen atom and two lone-pair electrons on the oxygen atom of an EG molecule.	Hydrogen	265-273	Mix paired-like homeobox	Homo sapiens	183-186
24329062-3	2013	The equilibrium structure is linear HCN-H2 with the nitrogen pointing towards H2 at an intermolecular separation of 7.20 a0.	Hydrogen	40-42	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	36-39
32490491-5	2020	Molecular docking results showed that hydrophobic and hydrogen bonding forces played a dominant role in the binding of ECG to tyrosinase, affecting the binding affinity of l-dopa to tyrosinase, leading to a decrease in tyrosinase activity.	Hydrogen	54-62	tyrosinase	Homo sapiens	126-136
32490491-5	2020	Molecular docking results showed that hydrophobic and hydrogen bonding forces played a dominant role in the binding of ECG to tyrosinase, affecting the binding affinity of l-dopa to tyrosinase, leading to a decrease in tyrosinase activity.	Hydrogen	54-62	tyrosinase	Homo sapiens	182-192
24329062-3	2013	The equilibrium structure is linear HCN-H2 with the nitrogen pointing towards H2 at an intermolecular separation of 7.20 a0.	Hydrogen	78-80	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	36-39
32490491-5	2020	Molecular docking results showed that hydrophobic and hydrogen bonding forces played a dominant role in the binding of ECG to tyrosinase, affecting the binding affinity of l-dopa to tyrosinase, leading to a decrease in tyrosinase activity.	Hydrogen	54-62	tyrosinase	Homo sapiens	182-192
10913129-2	2000	In light of this, we sought to use an established mouse hepatocyte cell line, H2-35, to further define the mechanism by which glucose regulates nuclear SREBP-1 levels.	Hydrogen	78-80	sterol regulatory element binding transcription factor 1	Mus musculus	152-159
24329062-5	2013	A secondary minimum of -183.59 cm(-1) was found for a T-shape configuration with the H of HCN pointing to the center of mass of H2.	Hydrogen	128-130	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	90-93
24329062-8	2013	The calculated ro-vibrational transitions in the HCN-H2 complex are found to agree by more than 0.5% with the available experimental data, confirming the accuracy of the potential energy surface.	Hydrogen	53-55	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	49-52
24329071-2	2013	It is shown that the reaction between H and HCN leads to both the hydrogen exchange and hydrogen abstraction channels.	Hydrogen	66-74	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	44-47
32606602-10	2020	Also, the performed docking simulation of ganoderic acid exhibited good fitting and binding with HMGB-1 through hydrogen bond formation with conservative amino acids which gives a strong evidence for its hepatoprotective effect and may interpret the effect of Ganoderma lucidum.	Hydrogen	112-120	high mobility group box 1	Rattus norvegicus	97-103
24329071-2	2013	It is shown that the reaction between H and HCN leads to both the hydrogen exchange and hydrogen abstraction channels.	Hydrogen	88-96	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	44-47
11052091-2	2000	The analysis of the X-ray crystal structures of three of those fluorinated TTF demonstrates the efficiency of the nonbonded fluorine exclusion interactions for the stabilization of layered structures with fluorous bilayers, together with S...S van der Waals interactions and C-H...F hydrogen bonds.	Hydrogen	283-291	ras homolog family member H	Homo sapiens	75-78
24117601-17	2013	ferridurans grown aerobically on hydrogen (c. 10(10)  cells mL(-1) ) were far greater than typically obtained using other electron donors.	Hydrogen	33-41	L1 cell adhesion molecule	Mus musculus	60-66
11014451-3	2000	The fragmentation pathway for the formation of the [M - H - RxCO2H]- ions, reflecting neutral loss of fatty acid, is a charge-remote process, which involves the participation of the hydrogens at C-1 and C-2 of the glycerol, resulting in [M - H - R2CO2H]- &gt; [M - H - R1CO2H]-.	Hydrogen	182-191	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	195-198
11014451-3	2000	The fragmentation pathway for the formation of the [M - H - RxCO2H]- ions, reflecting neutral loss of fatty acid, is a charge-remote process, which involves the participation of the hydrogens at C-1 and C-2 of the glycerol, resulting in [M - H - R2CO2H]- &gt; [M - H - R1CO2H]-.	Hydrogen	182-191	complement C2	Homo sapiens	203-206
31969689-8	2020	The vonoprazan-H+/K+-ATPase binding rate constant k was 0.07028 min-1  muM-1 using ratio of kd to KI.	Hydrogen	4-16	PWWP domain containing 3A, DNA repair factor	Homo sapiens	71-76
32841201-3	2020	Statistically significant differences in the levels of PCT and LBP were detected in the subgroups of OIO 1 day and SIO 1h/6h, the maximum values were found in the subgroup of OIO 1 day, with SIO the levels of PCT and LBP gradually increased in the post-reperfusion period.	Hydrogen	119-121	lipopolysaccharide binding protein	Rattus norvegicus	63-66
23933556-4	2013	However, a doublet was observed for AP, in CCl4, which can be attributed to this conformer and the lowest wavenumber component to the cis dimer form, stabilized through intermolecular hydrogen bonds (NH       OC).	Hydrogen	184-192	C-C motif chemokine ligand 4	Homo sapiens	43-47
32379301-0	2020	Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: A 1H-NMR-based metabolomic study in pancreatic cancer cells.	Hydrogen	76-78	solute carrier family 6 member 14	Homo sapiens	18-25
11076080-8	2000	1H-NMR studies on the interaction of alpha-D-methyl-mannoside with ligand 18/18 in solution confirm the involvement of the hydroxyl group in the C-2 position.	Hydrogen	0-2	complement C2	Homo sapiens	145-148
11076080-9	2000	Molecular modelling suggests the formation of four hydrogen bonds between the hydroxyl groups at positions C-2, C-3 and C-4 of alpha-D-methyl-mannoside and the bridging and ring nitrogen atoms of the triazine scaffold, with aromatic stacking of a second ligand against the carbohydrate face.	Hydrogen	51-59	complement C4A (Rodgers blood group)	Homo sapiens	120-123
24117141-7	2013	The structural characteristics for an (iso)flavonoid to activate hTAS2R14 (or hTAS2R39) were determined by 3D-pharmacophore models to be composed of two (or three) hydrogen bond donor sites, one hydrogen bond acceptor site, and two aromatic ring structures, of which one had to be hydrophobic.	Hydrogen	164-172	taste 2 receptor member 14	Homo sapiens	65-73
10931200-3	2000	From these measurements, it was possible to deduce information about the hydrogen-bonding pattern of FMN in the protein, the hybridization states of the nitrogen atoms and (in part) the pi-electron distribution.	Hydrogen	73-81	formin 1	Homo sapiens	101-104
32472203-0	2020	Intermolecular hydrogen bond interactions in the thiourea/water complexes (Thio-(H2O)n) (n = 1, ..., 5): X-ray, DFT, NBO, AIM, and RDG analyses.	Hydrogen	15-23	acetyl-CoA acyltransferase 1	Homo sapiens	75-79
24117141-7	2013	The structural characteristics for an (iso)flavonoid to activate hTAS2R14 (or hTAS2R39) were determined by 3D-pharmacophore models to be composed of two (or three) hydrogen bond donor sites, one hydrogen bond acceptor site, and two aromatic ring structures, of which one had to be hydrophobic.	Hydrogen	195-203	taste 2 receptor member 14	Homo sapiens	65-73
24081438-6	2013	The radial distribution function was also used to study the local structures of the polymers, and this revealed that increasing the temperature and cross linking density results in a significant drop in hydrogen bonding intensity in the cross-linked PUF systems.	Hydrogen	203-211	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	250-253
32239943-6	2020	While the lowest-energy fluorine loss occurs directly, the first H-loss and CF2-loss channels involve both a fluorine- and a hydrogen-migration prior to dissociation.	Hydrogen	125-133	ATPase H+ transporting accessory protein 1	Homo sapiens	76-79
11196867-1	2000	Eight adducts of Rh2(O2CCH3)4 with axial pyridine derivatives that contain hydrogen-bonding amino and/or steric methyl substituents in the 2- and 6-positions have been prepared and examined by electronic absorption and 1H NMR spectroscopy in solution and by elemental, IR, thermogravimetric, and X-ray diffraction analyses in the solid state.	Hydrogen	75-83	Rh associated glycoprotein	Homo sapiens	17-20
11196867-1	2000	Eight adducts of Rh2(O2CCH3)4 with axial pyridine derivatives that contain hydrogen-bonding amino and/or steric methyl substituents in the 2- and 6-positions have been prepared and examined by electronic absorption and 1H NMR spectroscopy in solution and by elemental, IR, thermogravimetric, and X-ray diffraction analyses in the solid state.	Hydrogen	219-221	Rh associated glycoprotein	Homo sapiens	17-20
11196867-2	2000	The results indicated that strong hydrogen bonding interactions between Rh2(O2CCH3)4 and axially coordinated pyridine derivatives with a 2- or 6-amino group occur in both solution and the solid state and contribute to the higher thermal stability of the molecular assembly of dirhodium complexes.	Hydrogen	34-42	Rh associated glycoprotein	Homo sapiens	72-75
24066973-5	2013	It is postulated that the formation of the alpha-syn:DA oligomers involves the cross-linking of DA-melanin with alpha-syn, via covalent linkage, hydrogen and hydrophobic interactions.	Hydrogen	145-153	synuclein alpha	Homo sapiens	43-52
10959640-0	2000	Letter to the editor: 1H, 15N, and 13C NMR backbone assignments and secondary structure of the C-terminal recombinant fragment of auxilin including the J-domain.	Hydrogen	22-24	DnaJ heat shock protein family (Hsp40) member C6	Homo sapiens	130-137
32187371-0	2020	Enhanced affinity of racemic phosphorothioate DNA with transcription factor SATB1 arising from diastereomer-specific hydrogen bonds and hydrophobic contacts.	Hydrogen	117-125	SATB homeobox 1	Homo sapiens	76-81
31916329-5	2020	Instead, the reduction in intraglomerular pressures may be related to an action of SGLT2 inhibitors to interfere with the activity of sodium-hydrogen exchanger isoform 3 (NHE-3), thereby inhibiting proximal tubular sodium reabsorption and promoting tubuloglomerular feedback.	Hydrogen	134-149	solute carrier family 9 member A3	Homo sapiens	171-176
24066973-5	2013	It is postulated that the formation of the alpha-syn:DA oligomers involves the cross-linking of DA-melanin with alpha-syn, via covalent linkage, hydrogen and hydrophobic interactions.	Hydrogen	145-153	synuclein alpha	Homo sapiens	112-121
10847612-7	2000	A one-dimensional 1H NMR comparison of MDC-FibN and unmodified FibN suggested that the first incorporation of MDC at Gln3 altered the substrate reactivity of the Gln4 residue in FibN for the G-TGase-catalyzed reaction.	Hydrogen	18-20	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	191-198
23903205-1	2013	The activation of H2 using Mes3P-AlX3 (X = Cl, Br, I) FLPs was investigated.	Hydrogen	18-20	ALX homeobox 3	Homo sapiens	33-37
10893720-3	2000	A detailed mechanism is proposed based on monitoring the reaction by 1H- and 13C-NMR spectroscopy, MS, FAB, HPLC, and pH meter.	Hydrogen	69-71	FA complementation group B	Homo sapiens	103-106
10756109-9	2000	We identified C-H.O hydrogen bonds between the drug and protein that may be an important feature of cyclophilins and suggest a general mode of interaction between hydrophobic molecules.	Hydrogen	20-28	peptidylprolyl isomerase A	Homo sapiens	100-112
31652343-3	2020	Glu427 is invariant in the ALDH superfamily and forms ionic hydrogen bonds with the nicotinamide ribose of the NAD+ cofactor.	Hydrogen	60-68	aldehyde dehydrogenase 7 family member A1	Homo sapiens	27-31
32314789-0	2020	Hydrogen gas represses the progression of lung cancer via downregulating CD47.	Hydrogen	0-8	CD47 molecule	Homo sapiens	73-77
24124590-11	2013	Modeling and our experimental results suggest that the adenine ring of SAM is sandwiched between Ile136 and Met103, the amide group of SAM is hydrogen bonded to Gly78 in hAS3MT and SAM is bonded to Tyr59 with van der Waals, cation-pi and hydrogen bonding contacts.	Hydrogen	142-150	PDS5 cohesin associated factor B	Homo sapiens	170-174
32365630-5	2020	Binding of gallacetophenone to the active site of tyrosinase was found to be stabilized by hydrophobic interactions with His367, Ile368, and Val377; hydrogen bonding with Ser380 and a water molecule bridging the copper ions.	Hydrogen	149-157	tyrosinase	Homo sapiens	50-60
32320994-4	2020	Our results showed that the lifespans of the N2, sod-3 and sod-5 mutant strains were extended by approximately 22.7%, 9.5%, and 8.7%, respectively, after hydrogen treatment, but hydrogen had no effect on the lifespans of the daf-2 and daf-16 mutant strains.	Hydrogen	154-162	Superoxide dismutase [Cu-Zn]	Caenorhabditis elegans	59-64
24124590-11	2013	Modeling and our experimental results suggest that the adenine ring of SAM is sandwiched between Ile136 and Met103, the amide group of SAM is hydrogen bonded to Gly78 in hAS3MT and SAM is bonded to Tyr59 with van der Waals, cation-pi and hydrogen bonding contacts.	Hydrogen	238-246	PDS5 cohesin associated factor B	Homo sapiens	170-174
24007343-11	2013	Binding to the open pore conformation of p97 occurs primarily at the Arg599 side chain, where the SP backbone is engaged through electrostatic interactions and hydrogen bonds.	Hydrogen	160-168	melanotransferrin	Homo sapiens	41-44
32337406-9	2020	The simulation results highlight the importance of hydrogen bonds and the salt bridge between Lys94 of MDM2 and Glu17 of p53 in the stability of the p53-MDM2 complex.	Hydrogen	51-59	MDM2 proto-oncogene	Homo sapiens	153-157
11272581-5	2000	The 1H and 13C NMR data for N3P3X5OCH=CH2 (X = F, Cl, OMe, OCH2CF3, NMe2) show significant changes as a function of the phosphazene substituent.	Hydrogen	4-6	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	68-72
11272581-9	2000	The 1H NMR spectra of the N3P3(NMe2)4(OCH-CH2)2 isomeric mixture allow for assignment of the relative amounts of cis and trans isomers.	Hydrogen	4-6	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	31-35
22918595-0	2013	1H, 13C, and 15N backbone resonance assignments of the L124D mutant of StAR-related lipid transfer domain protein 4 (StARD4).	Hydrogen	0-2	StAR related lipid transfer domain containing 4	Homo sapiens	71-115
10888036-8	2000	Compounds with low affinity for CDK1 were poor charge acceptors and made less than ideal hydrogen bonding arrangements with the receptor.	Hydrogen	89-97	cyclin dependent kinase 1	Homo sapiens	32-36
32244797-6	2020	The newly formed alphaN helix of hSNF5171-258 interacts with the beta2-alpha1 loop of hSNF5 via hydrogen bonds and it also displays a hydrophobic interaction with BAF155SWIRM.	Hydrogen	96-104	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	Homo sapiens	163-169
32292396-5	2020	MAA 1 has a molecular weight of 467 and MAA 2 of 305, and the latter (MAA 2) was identified as N-(4,5-dihydroxy-5-(hydroxymethyl)-2-methoxy-3-oxocyclohex-1-en-1-yl)-N-methylserine using one- and two-dimensional 1H and 13C-NMR spectroscopy.	Hydrogen	211-213	BCL6 corepressor	Homo sapiens	70-75
10935206-0	2000	QM/MM and SCRF studies of the ionization state of 8-methylpterin substrate bound to dihydrofolate reductase: existence of a low-barrier hydrogen bond.	Hydrogen	136-144	dihydrofolate reductase	Homo sapiens	84-107
22918595-0	2013	1H, 13C, and 15N backbone resonance assignments of the L124D mutant of StAR-related lipid transfer domain protein 4 (StARD4).	Hydrogen	0-2	StAR related lipid transfer domain containing 4	Homo sapiens	117-123
10935206-1	2000	Using combined semiempirical quantum mechanics and molecular mechanics (QM/MM) and ab initio self-consistent reaction field (SCRF) calculations, we determined that a low-barrier hydrogen bond (LBHB) is formed when the mechanism-based substrate 8-methylpterin binds to dihydrofolate reductase (DHFR).	Hydrogen	178-186	dihydrofolate reductase	Homo sapiens	268-291
10935206-1	2000	Using combined semiempirical quantum mechanics and molecular mechanics (QM/MM) and ab initio self-consistent reaction field (SCRF) calculations, we determined that a low-barrier hydrogen bond (LBHB) is formed when the mechanism-based substrate 8-methylpterin binds to dihydrofolate reductase (DHFR).	Hydrogen	178-186	dihydrofolate reductase	Homo sapiens	293-297
22957718-2	2013	We determined a series of pharmacological descriptors (molecular surfaces, volumes, electrostatic energies, solvation energies, number of atoms, number of hydrogen donors or acceptors and number of rigid bonds) for the gp120 CD4-binding sites structures in the unliganded state from a reference panel of 60 diverse strains of HIV-1.	Hydrogen	155-163	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	219-224
10593884-0	1999	Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction.	Hydrogen	103-111	steroid sulfatase	Homo sapiens	121-125
10593884-4	1999	In this report glutaredoxin 2 is shown to be the most effective hydrogen donor for the reduction of arsenate by ArsC.	Hydrogen	64-72	steroid sulfatase	Homo sapiens	112-116
31952595-2	2020	In this work, a novel dual ROS-sensitive and CD44 receptors targeting amphiphilic carrier material, oligomeric hyaluronic acid-2"-[propane-2,2-diyllbls (thio)] diacetic acl-hydroxymethylferrocene (oHA-TKL-Fc), named HASF, was synthesized and characterized by 1H-NMR spectra.	Hydrogen	259-261	CD44 antigen	Mus musculus	45-49
32440336-7	2020	The molecular docking studies suggest hydrogen bonding, hydrophobic and pi-pair interactions with the active site of epidermal growth factor receptor, vascular endothelial growth factor receptor 2 and lipoxygenase receptors.	Hydrogen	38-46	kinase insert domain receptor	Homo sapiens	151-196
23963851-6	2013	Three-dimensional models showed that the change from proline to leucine (p.P285L) could attenuate the hydrogen bond between S284 and S287 residues, which might affect function of serine protease HTRA1.	Hydrogen	102-110	HtrA serine peptidase 1	Homo sapiens	195-200
32155763-6	2020	These theoretical data suggested that the electron-donating effect of the diethylamino group in TSC-2 leads to the enhancement of the scavenging activities and the studied compounds may prefer to undergo the hydrogen atom transfer process.	Hydrogen	208-216	TSC complex subunit 2	Homo sapiens	96-101
10545200-7	1999	Insertions and deletions in this region of cytochrome c(2), the presence of a proline near the methionine, and the smaller size of the dynamic region of horse cytochrome c suggest that the stabilizing hydrogen bond is not present in horse cytochrome c, hence, the dramatic difference in affinity for imidazole.	Hydrogen	201-209	cytochrome c, somatic	Equus caballus	43-55
10545200-7	1999	Insertions and deletions in this region of cytochrome c(2), the presence of a proline near the methionine, and the smaller size of the dynamic region of horse cytochrome c suggest that the stabilizing hydrogen bond is not present in horse cytochrome c, hence, the dramatic difference in affinity for imidazole.	Hydrogen	201-209	cytochrome c, somatic	Equus caballus	159-171
10545200-7	1999	Insertions and deletions in this region of cytochrome c(2), the presence of a proline near the methionine, and the smaller size of the dynamic region of horse cytochrome c suggest that the stabilizing hydrogen bond is not present in horse cytochrome c, hence, the dramatic difference in affinity for imidazole.	Hydrogen	201-209	cytochrome c, somatic	Equus caballus	159-171
23831214-6	2013	EphB2 overexpression could prevent the neurotoxicity of hippocampal neurons from exposure to Abeta1-42 oligomers for 1h.	Hydrogen	117-119	EPH receptor B2	Homo sapiens	0-5
10547279-1	1999	Folding of equine cytochrome c at a low protein concentration (26 microM) eliminated a slow kinetic phase (time constant three seconds) that was observed in the previous hydrogen exchange pulse-labeling experiments at pH 6.2 and 10 degrees C. It was demonstrated that this slow folding phase was caused by intermolecular aggregations.	Hydrogen	170-178	cytochrome c, somatic	Equus caballus	18-30
30345819-5	2020	Molecular docking further revealed that LCB inhibited Abeta42 self-aggregation through forming two hydrogen bonds with Lys28 to block the salt bridge interaction at the C-terminus of Abeta42.	Hydrogen	99-107	clathrin light chain B	Homo sapiens	40-43
32045211-4	2020	Neutron powder diffraction and reduction of the material in a hydrogen atmosphere (H2-TPR) can confirm the oxygen overstoichiometry of the catalyst.	Hydrogen	62-70	translocated promoter region, nuclear basket protein	Homo sapiens	86-89
23764826-6	2013	The calculated redox tuning of Co(I)H interactions on the reduction potential of Co(II)/Co(I) couple (60-800 mV vs standard hydrogen electrode (SHE)), irrespective of the beta-axial ligand considered, is significantly higher than the biological redox gap between the reduction potential of Co(II)/Co(I) couple and that of the biological reducing agents (50 mV vs SHE).	Hydrogen	124-132	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	88-93
31794666-4	2020	As observed from molecular dynamics simulations, the C13-dipeptides firstly form small aggregates through hydrophobic interactions and then rearranged through electrostatic attractions and hydrogen bonds for self-assembly.	Hydrogen	189-197	homeobox C13	Homo sapiens	53-56
31794666-5	2020	The C13-dipeptides tended to be anti-parallel packed as shown by hydrogen bonding analyses.	Hydrogen	65-73	homeobox C13	Homo sapiens	4-7
31794666-8	2020	For C13-WS strong hydrogen bonding was found, and in C13-WY both of strong  -  interactions and hydrogen bonds were found.	Hydrogen	96-104	homeobox C13	Homo sapiens	53-56
31794666-9	2020	It takes around 90 minutes or longer for C13-dipeptides to form hydrogels and those formed by C13-WY and C13-WS had weak water holding capacities, which might be due to strong intermolecular hydrogen bonding.	Hydrogen	191-199	homeobox C13	Homo sapiens	41-44
31794666-9	2020	It takes around 90 minutes or longer for C13-dipeptides to form hydrogels and those formed by C13-WY and C13-WS had weak water holding capacities, which might be due to strong intermolecular hydrogen bonding.	Hydrogen	191-199	homeobox C13	Homo sapiens	94-97
31794666-9	2020	It takes around 90 minutes or longer for C13-dipeptides to form hydrogels and those formed by C13-WY and C13-WS had weak water holding capacities, which might be due to strong intermolecular hydrogen bonding.	Hydrogen	191-199	homeobox C13	Homo sapiens	94-97
10548199-9	1999	MEASUREMENTS AND MAIN RESULTS: Standard hemodynamic measurements and echocardiographic data demonstrated that HS-HES and HS induced a higher increase in left ventricular end-diastolic area than HES.	Hydrogen	110-112	ribosome binding protein 1	Homo sapiens	113-116
10548199-10	1999	In the HS-HES and HS groups, systemic vascular resistances decreased significantly and end-systolic area tended to decrease.	Hydrogen	7-9	ribosome binding protein 1	Homo sapiens	10-13
10548199-13	1999	A major increase in cardiac index was observed after hypertonic solutions infusion, from 2.9 +/- 0.3 to 4.1 +/- 0.4 L/min/m2 in the HS-HES group and from 2.7 +/- 0.3 to 3.8 +/- 0.4 L/min/m2 in the HS group.	Hydrogen	132-134	ribosome binding protein 1	Homo sapiens	135-138
23764826-6	2013	The calculated redox tuning of Co(I)H interactions on the reduction potential of Co(II)/Co(I) couple (60-800 mV vs standard hydrogen electrode (SHE)), irrespective of the beta-axial ligand considered, is significantly higher than the biological redox gap between the reduction potential of Co(II)/Co(I) couple and that of the biological reducing agents (50 mV vs SHE).	Hydrogen	124-132	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	88-93
10548067-1	1999	The human Theta class glutathione transferase GSTT2-2 has a novel sulfatase activity that is not dependent on the presence of a conserved hydrogen bond donor in the active site.	Hydrogen	138-146	glutathione S-transferase theta 2 (gene/pseudogene)	Homo sapiens	46-53
23607811-9	2013	In addition to the hydrogen bond acceptor, hydrophobic character, electro withdrawing character positively contributes to the DPP-IV inhibition.	Hydrogen	19-27	dipeptidyl peptidase 4	Homo sapiens	126-132
32029834-4	2020	The characterization of the resulting compound, Pd@C, and comparing it with Pd@Hal@C, showed that etching of Hal significantly increased the specific surface area and pore volume in Pd@C. Pd@C was successfully used as a heterogeneous catalyst for promoting hydrogenation of nitroarens in aqueous media using hydrogen with atmospheric pressure as a reducing agent.	Hydrogen	257-265	histidine ammonia-lyase	Homo sapiens	79-82
32029834-4	2020	The characterization of the resulting compound, Pd@C, and comparing it with Pd@Hal@C, showed that etching of Hal significantly increased the specific surface area and pore volume in Pd@C. Pd@C was successfully used as a heterogeneous catalyst for promoting hydrogenation of nitroarens in aqueous media using hydrogen with atmospheric pressure as a reducing agent.	Hydrogen	257-265	histidine ammonia-lyase	Homo sapiens	109-112
23909841-5	2013	The interactions between ligands and alpha-glucosidase were mainly driven by hydrophobic force, or hydrogen bonding consequently induced conformational changes and reduced surface hydrophobicity.	Hydrogen	99-107	sucrase-isomaltase	Homo sapiens	37-54
31629975-6	2020	AtGPX6 exhibits a single binding site with lead ions, and then the complex formation was mainly driven by hydrogen bonding interaction and van der Waals forces on account of the negative DeltaH and DeltaS.	Hydrogen	106-114	glutathione peroxidase 6	Arabidopsis thaliana	0-6
31259781-6	2020	Activation of HIF-1alpha is detrimental to ALI induced by T/HS.	Hydrogen	60-62	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	14-24
10568292-2	1999	Hydrogen-3 and 3H-3He data indicate that the deep basins of the sea are rapidly ventilated, although the hydraulic turnover time of the sea is approximately 200 years.	Hydrogen	0-8	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	64-67
10530928-14	1999	Both enantiomers of 1 could form a hydrogen bond between their 5-methoxy substituent and Thr200 in TM5, which may account for their full serotonin 5-HT1A receptor agonist properties.	Hydrogen	35-43	5-hydroxytryptamine receptor 1A	Homo sapiens	147-162
31259781-7	2020	Thus, our data suggest that HIF-1alpha activation by T/HS is necessary for T/HS-induced lung injury and a critical role for SDH in the initiation of acute inflammatory response after ALI.	Hydrogen	55-57	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	28-38
23598885-0	2013	Fabrication of NiS modified CdS nanorod p-n junction photocatalysts with enhanced visible-light photocatalytic H2-production activity.	Hydrogen	111-113	CDP-diacylglycerol synthase 1	Homo sapiens	28-31
32005101-13	2020	For Danish Jersey, wavenumbers that interact with C-H were associated to genes that are involved in fatty acid synthesis, such as AGPAT3, AGPAT6, PPARGC1A, SREBF1, and FADS1.	Hydrogen	50-53	fatty acid desaturase 1	Bos taurus	168-173
10541224-1	1999	The sodium-hydrogen exchanger regulatory factor (NHERF) was first identified as an essential cofactor for cyclic AMP-mediated inhibition of the epithelial isoform of rabbit kidney sodium-hydrogen exchanger (NHE3).	Hydrogen	11-19	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	207-211
23598885-3	2013	Even without the Pt co-catalyst, the as-prepared NiS NP-CdS NR samples exhibited enhanced visible-light photocatalytic activity and good stability for H2-production.	Hydrogen	151-153	CDP-diacylglycerol synthase 1	Homo sapiens	56-59
10619705-4	1999	Using beta4GalT1 from human milk, a preparative enzymatic synthesis of UDP-LacNAc was carried out, and the product was characterized by fast-atom bombardment mass spectrometry and 1H and 13C NMR spectroscopy.	Hydrogen	180-182	beta-1,4-galactosyltransferase 1	Homo sapiens	6-16
31869201-8	2020	We proposed a possible "refolding-after-unfolding" mechanism, as further supported by monitoring hydrogen elimination from radical a-ions produced by UVPD at the N-terminus of ADH.	Hydrogen	97-105	aldo-keto reductase family 1 member A1	Homo sapiens	176-179
23598885-4	2013	The optimal NiS loading content was determined to be 5 mol%, and the corresponding H2-production rate reached 1131 mumol h(-1) g(-1), which is even higher than that of the optimized Pt-CdS NRs.	Hydrogen	83-85	CDP-diacylglycerol synthase 1	Homo sapiens	185-188
23728221-2	2013	The remarkable photocurrent density (~4 mA cm(-2) at a potential of 0 V versus Ag/AgCl) and high solar to hydrogen efficiency of the materials obtained were ascribed to the novel branched nanostructure and efficient electron transfer from CdS to TiO2.	Hydrogen	106-114	CDP-diacylglycerol synthase 1	Homo sapiens	239-242
31968689-3	2020	The key transitional region, from 85 to 92.5 mol% water, which coincides with the mixture"s maximum cellulose solubility, reveals small and distinct water veins with cage structures formed by the TBP+ ions, while the hydroxide and chloride ions have moved away from the P atom of TBP+ and are strongly hydrogen bonded to the water.	Hydrogen	302-310	TATA-box binding protein	Homo sapiens	196-199
23679855-4	2013	Huprine W in hAChE and tacrine in hBChE reside in strikingly similar positions highlighting the conservation of key interactions, namely, pi-pi/cation-pi interactions with Trp86 (Trp82), and hydrogen bonding with the main chain carbonyl of the catalytic histidine residue.	Hydrogen	191-199	butyrylcholinesterase	Homo sapiens	34-39
31613081-3	2020	In this work, we use Hydrogen-Deuterium eXchange (HDX) and Isothermal Titration Calorimetry (ITC) to characterize the binding interaction between Lcn2 and siderophores enterobactin and 2,3-DHBA, in the presence and absence of iron.	Hydrogen	21-29	lipocalin 2	Homo sapiens	146-150
10481277-0	1999	1H and 15N chemical shift assignments for domain 4 of the common beta-chain of the IL-3, IL-5 and GM-CSF receptors.	Hydrogen	0-2	interleukin 3	Homo sapiens	83-87
10481277-0	1999	1H and 15N chemical shift assignments for domain 4 of the common beta-chain of the IL-3, IL-5 and GM-CSF receptors.	Hydrogen	0-2	colony stimulating factor 2	Homo sapiens	98-104
23758282-0	2013	Conserved hydrogen bonding networks of MitoNEET tune Fe-S cluster binding and structural stability.	Hydrogen	10-18	CDGSH iron sulfur domain 1	Homo sapiens	39-47
31888991-6	2020	This bimodal RhoA binding of Ect2 is unusual and was confirmed with Forster resonance energy transfer (FRET) and hydrogen-deuterium exchange mass spectrometry (HDX-MS) analyses.	Hydrogen	113-121	epithelial cell transforming 2	Homo sapiens	29-33
30652647-10	2020	Molecular docking studies on EGFR (PDB ID: 1M17) results, the compounds 6d, 6j and 6l showed good dock/PLP scores i.e.-81.28, -73.98 and -75.37 by interacting with Leu-694, Val-702and Gly-772 amino acids via hydrophobic and hydrogen bonds with Asn818 and Met-769.	Hydrogen	224-232	proteolipid protein 1	Homo sapiens	103-106
23869809-8	2013	The toxicity for type B trichothecenes decreases if the substituent at C-4 is changed from acetoxy to hydroxyl or hydrogen at C-4 position.	Hydrogen	114-122	complement C4A (Rodgers blood group)	Homo sapiens	71-74
31675512-7	2020	Molecular modeling studies showed that compound 2a is inserted between helix alpha3 and alpha4 of the KRas protein making interactions with the hydrophobic residues Phe90, Glu91, Ile9364, Hie94, Leu133 and Tyr137and a hydrogen bond with residue Arg97.	Hydrogen	218-226	KRAS proto-oncogene, GTPase	Homo sapiens	102-106
23869809-8	2013	The toxicity for type B trichothecenes decreases if the substituent at C-4 is changed from acetoxy to hydroxyl or hydrogen at C-4 position.	Hydrogen	114-122	complement C4A (Rodgers blood group)	Homo sapiens	126-129
23315172-0	2013	1H-MRS assessment of the therapeutic effect of bilateral intraventricular BDNF infusion into APP/PS1 double transgenic mice.	Hydrogen	0-2	brain derived neurotrophic factor	Mus musculus	74-78
32065789-5	2020	MAPT haplotypes show different levels of MAPT/Tau expression with H1 being ~1.5-fold more expressed than H2, suggesting that MAPT expression level could be related to LOAD risk.	Hydrogen	66-68	tau	Drosophila melanogaster	46-49
32065789-8	2020	The exacerbation of neuronal defects correlates with the accumulation of insoluble dTau oligomers, suggesting that the moderate difference in level of tau expression observed between H1 and H2 haplotypes could influence Abeta toxicity through the production of oligomeric tau insoluble species.	Hydrogen	183-185	tau	Drosophila melanogaster	151-154
23315172-5	2013	In the present study, 1H-MRS was used to evaluate the therapeutic effects of bilateral intraventricular BDNF infusion into Alzheimer"s disease APP/PS1 double transgenic mice.	Hydrogen	22-24	brain derived neurotrophic factor	Mus musculus	104-108
23315172-10	2013	These findings demonstrate that 1H-MRS may be a promising means of evaluating the therapeutic effects of BDNF on AD.	Hydrogen	32-34	brain derived neurotrophic factor	Mus musculus	105-109
31640480-9	2020	These findings provide multiple data supporting the cross-reactivity of the Ber-H2 anti-CD30 clone in feline tissues and give evidence of the usefulness of CD30 in the diagnostic evaluation of feline lymphoma.	Hydrogen	80-82	TNF receptor superfamily member 8	Homo sapiens	88-92
23816907-4	2013	A quantum efficiency (QE) as high as 93 per cent at 420 nm for H2 production has been achieved for Pt-PdS/CdS, where Pt and PdS, respectively, act as reduction and oxidation cocatalysts and CdS as a photo-harvester.	Hydrogen	63-65	CDP-diacylglycerol synthase 1	Homo sapiens	106-109
31889156-8	2019	Using hydrogen-deuterium exchange, we mapped regions involved in TM-dependent RAGE oligomerization.	Hydrogen	6-14	advanced glycosylation end-product specific receptor	Homo sapiens	78-82
23816907-4	2013	A quantum efficiency (QE) as high as 93 per cent at 420 nm for H2 production has been achieved for Pt-PdS/CdS, where Pt and PdS, respectively, act as reduction and oxidation cocatalysts and CdS as a photo-harvester.	Hydrogen	63-65	CDP-diacylglycerol synthase 1	Homo sapiens	190-193
31714771-6	2019	For ligand-dependent actions, we examined the ligand-bound simulations and identified two sets of ligand-induced contacts promoting CAR activation via co-activator binding (H11-H12 contact) or inactivation via co-repressor binding (H4-H11 contact).	Hydrogen	173-180	nuclear receptor subfamily 1 group I member 3	Homo sapiens	132-135
31714771-6	2019	For ligand-dependent actions, we examined the ligand-bound simulations and identified two sets of ligand-induced contacts promoting CAR activation via co-activator binding (H11-H12 contact) or inactivation via co-repressor binding (H4-H11 contact).	Hydrogen	232-238	nuclear receptor subfamily 1 group I member 3	Homo sapiens	132-135
23826519-0	2013	Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells.	Hydrogen	10-18	microRNA 21	Homo sapiens	54-60
23826519-5	2013	RESULTS: The results demonstrated a marked down-regulation of miR-9 and miR-21 and up-regulation of miR-199 by hydrogen treatment; the expression of Myd88 and IKK-beta was decreased after hydrogen treatment, whereas PDCD4 was increased, and there was no significant change in NF-kappaB expression.	Hydrogen	111-119	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	159-167
31864267-1	2019	We investigated the reaction of methyl formate, HC(O)OCH3, with hydrogen atoms in solid para-hydrogen (p-H2) at 1.74 and 3.3 K with infrared absorption spectroscopy.	Hydrogen	64-72	polyhomeotic homolog 2	Homo sapiens	103-107
31864267-1	2019	We investigated the reaction of methyl formate, HC(O)OCH3, with hydrogen atoms in solid para-hydrogen (p-H2) at 1.74 and 3.3 K with infrared absorption spectroscopy.	Hydrogen	88-101	polyhomeotic homolog 2	Homo sapiens	103-107
31864267-2	2019	Hydrogen atoms were produced either upon direct photolysis of HC(O)OCH3 at 193 nm or upon irradiation of Cl2, codeposited with HC(O)OCH3 in p-H2, with light at 365 nm to produce Cl atoms that react with the p-H2 host via the reaction Cl + H2 (nu = 1)   HCl + H induced by subsequent IR irradiation of the p-H2 matrix.	Hydrogen	0-8	endogenous retrovirus group W member 5	Homo sapiens	105-108
31864267-2	2019	Hydrogen atoms were produced either upon direct photolysis of HC(O)OCH3 at 193 nm or upon irradiation of Cl2, codeposited with HC(O)OCH3 in p-H2, with light at 365 nm to produce Cl atoms that react with the p-H2 host via the reaction Cl + H2 (nu = 1)   HCl + H induced by subsequent IR irradiation of the p-H2 matrix.	Hydrogen	0-8	polyhomeotic homolog 2	Homo sapiens	140-144
31864267-2	2019	Hydrogen atoms were produced either upon direct photolysis of HC(O)OCH3 at 193 nm or upon irradiation of Cl2, codeposited with HC(O)OCH3 in p-H2, with light at 365 nm to produce Cl atoms that react with the p-H2 host via the reaction Cl + H2 (nu = 1)   HCl + H induced by subsequent IR irradiation of the p-H2 matrix.	Hydrogen	0-8	polyhomeotic homolog 2	Homo sapiens	207-211
23826519-5	2013	RESULTS: The results demonstrated a marked down-regulation of miR-9 and miR-21 and up-regulation of miR-199 by hydrogen treatment; the expression of Myd88 and IKK-beta was decreased after hydrogen treatment, whereas PDCD4 was increased, and there was no significant change in NF-kappaB expression.	Hydrogen	188-196	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	159-167
31864267-2	2019	Hydrogen atoms were produced either upon direct photolysis of HC(O)OCH3 at 193 nm or upon irradiation of Cl2, codeposited with HC(O)OCH3 in p-H2, with light at 365 nm to produce Cl atoms that react with the p-H2 host via the reaction Cl + H2 (nu = 1)   HCl + H induced by subsequent IR irradiation of the p-H2 matrix.	Hydrogen	0-8	polyhomeotic homolog 2	Homo sapiens	207-211
23826519-6	2013	CONCLUSION: The results in the present study indicate that miR-9, miR-199 and miR-21 play an important role in the anti-inflammatory regulation of LPS-activated microglia cells by molecular hydrogen, which will help to explain the protective mechanism of molecular hydrogen against inflammatory injury.	Hydrogen	190-198	microRNA 21	Homo sapiens	78-84
23826519-6	2013	CONCLUSION: The results in the present study indicate that miR-9, miR-199 and miR-21 play an important role in the anti-inflammatory regulation of LPS-activated microglia cells by molecular hydrogen, which will help to explain the protective mechanism of molecular hydrogen against inflammatory injury.	Hydrogen	265-273	microRNA 21	Homo sapiens	78-84
23131022-5	2013	RESULTS: Studies have shown that increase in H2 S concentration could reduce the expression of UII, UT, collagen I, collagen III, TIMP-1 and alpha-SMA without involvement of CSE.	Hydrogen	45-47	urotensin 2	Homo sapiens	95-98
31775504-5	2019	While C10 atom of the substrate is found to be the most probable site of hydrogen abstraction in the wt-lox, hydrogen abstraction from C13 is more favorable in the mutants.	Hydrogen	73-81	chromosome 12 open reading frame 57	Homo sapiens	6-9
31775504-5	2019	While C10 atom of the substrate is found to be the most probable site of hydrogen abstraction in the wt-lox, hydrogen abstraction from C13 is more favorable in the mutants.	Hydrogen	73-81	homeobox C13	Homo sapiens	135-138
31775504-5	2019	While C10 atom of the substrate is found to be the most probable site of hydrogen abstraction in the wt-lox, hydrogen abstraction from C13 is more favorable in the mutants.	Hydrogen	109-117	homeobox C13	Homo sapiens	135-138
23131022-7	2013	The examination of cell proliferation by 5-ethynyl-2"-deoxyuridine assay suggests that H2 S significantly inhibited the proliferation of LX-2 cells and the proliferation-promoting effect of UII.	Hydrogen	87-89	urotensin 2	Homo sapiens	190-193
23563626-0	2013	Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis.	Hydrogen	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	94-97
31976320-10	2019	The comparison of the hydrogen and hydrophobic interactions in the wild type Stxbp1 structure and its mutant forms showed that all these nsSNPs affect the protein structure on different levels.	Hydrogen	22-30	syntaxin binding protein 1	Homo sapiens	77-83
23570516-6	2013	Hydrogen bonding interactions were observed between Tyr130 and secondary amino and C-4 acetyl groups as well as between heterocyclic nitrogen and Phe288 at a distance of 3.04 A. Hydrophobic interactions were evident between rings C/D of 4APB and with Phe288, Phe330 and Phe331.	Hydrogen	0-8	complement C4A (Rodgers blood group)	Homo sapiens	83-86
31842357-3	2019	SWI2/SNF2-Related 1 Chromatin Remodeling Complex (SWR1-C) belongs to the INO80 chromatin remodeling family and mainly catalyzes the exchange of H2A-H2B with the H2A.Z-H2B dimer.	Hydrogen	144-151	DNA helicase INO80-like protein	Arabidopsis thaliana	73-78
23541670-2	2013	The initial leads in this series, compounds 1a and 1h, showed promising potencies, but a lack of selectivity against other isoforms in the JAK family.	Hydrogen	51-53	Janus kinase 3	Homo sapiens	139-142
31822591-6	2019	This heterotypic interface resembles the interfaces observed in the individual homopolymers, albeit exhibiting a slight rearrangement of electrostatic interactions and hydrogen bonds, consistent with the heterotypic interaction being favored over the homotypic Axin DIX interaction.	Hydrogen	168-176	axin 1	Homo sapiens	261-265
30398220-7	2019	Despite contradictory views regarding the clinical relevance of asymptomatic post-procedural elevated hs-cTnI levels, it is generally believed that a mild elevation is not associated with an increased risk.	Hydrogen	102-104	troponin I3, cardiac type	Homo sapiens	105-109
22736569-6	2013	Denaturing agents targeting hydrogen bonds within HtrA destabilized HtrA oligomers while reducing agents disrupting disulfide bonds had no effect.	Hydrogen	28-36	HtrA serine peptidase 1	Homo sapiens	50-54
31506826-7	2019	Patients with hs-cTNI level elevation had a significantly greater likelihood of a history of coronary heart disease (p = 0.03) and a significantly shorter TGA duration at presentation (p &lt; 0.01).	Hydrogen	14-16	troponin I3, cardiac type	Homo sapiens	17-21
22736569-6	2013	Denaturing agents targeting hydrogen bonds within HtrA destabilized HtrA oligomers while reducing agents disrupting disulfide bonds had no effect.	Hydrogen	28-36	HtrA serine peptidase 1	Homo sapiens	68-72
23482963-2	2013	This composite material generates hydrogen and oxygen in the absence of a Pt co-catalyst and most importantly photocorrosion of CdS is completely eliminated.	Hydrogen	34-42	CDP-diacylglycerol synthase 1	Homo sapiens	128-131
31595750-2	2019	Among these M1/PTA SACs, Os1/PTA SAC possesses high activity for N2O reduction by H2 with a relevant low rate-determining barrier.	Hydrogen	82-84	frizzled related protein	Homo sapiens	25-28
31499004-5	2019	We assessed changes in protein flexibility connected to metal and alphaKG binding, finding that (M+alphaKG) binding significantly stabilized the cupin barrel core of FIH as evidenced by enhanced thermal stability and decreased protein dynamics as assessed by global amide hydrogen/deuterium exchange mass spectrometry and limited proteolysis.	Hydrogen	272-280	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	166-169
31065957-0	2019	Backbone 1H, 13C, and 15N resonance assignments of the PRY-SPRY domain of RNF135.	Hydrogen	9-11	ring finger protein 135	Homo sapiens	74-80
31065957-4	2019	Here we report the backbone 1H, 13C, and 15N chemical shift assignments of the PRY-SPRY domain of RNF135 and the secondary structure elements predicted based on chemical shifts, as well as the perturbations caused by the R286H mutation that is associated with MMFD syndrome.	Hydrogen	28-30	ring finger protein 135	Homo sapiens	98-104
23470147-8	2013	Because the model predicts that the peptide Trp side chain hydrogen bonding with gp120 S375 contributes to the stability of the PT-gp120 complex, we tested this prediction through analysis of peptide binding to gp120 mutant S375A.	Hydrogen	59-67	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	81-86
30484368-8	2019	In silico docking method has been employed to show that hydrogen bonds between PTL and the activity cavity of UGT1A1 contributed to the stronger inhibition of PTL on the activity of UGT1A1 than MCL.	Hydrogen	56-64	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	110-116
30484368-8	2019	In silico docking method has been employed to show that hydrogen bonds between PTL and the activity cavity of UGT1A1 contributed to the stronger inhibition of PTL on the activity of UGT1A1 than MCL.	Hydrogen	56-64	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	182-188
23470147-8	2013	Because the model predicts that the peptide Trp side chain hydrogen bonding with gp120 S375 contributes to the stability of the PT-gp120 complex, we tested this prediction through analysis of peptide binding to gp120 mutant S375A.	Hydrogen	59-67	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
23470147-8	2013	Because the model predicts that the peptide Trp side chain hydrogen bonding with gp120 S375 contributes to the stability of the PT-gp120 complex, we tested this prediction through analysis of peptide binding to gp120 mutant S375A.	Hydrogen	59-67	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
31575191-1	2019	We present an analytical model for the role of hydrogen bonding on the spin-orbit coupling of a model DNA molecule.	Hydrogen	47-55	spindlin 1	Homo sapiens	71-75
23331539-5	2013	Molecular docking studies revealed that the quinazolinon inhibitors interacted with human acrosin mainly through hydrogen bonding and hydrophobic interactions.	Hydrogen	113-121	acrosin	Homo sapiens	90-97
31575191-2	2019	Here, we analyze in detail the electric fields due to the polarization of the hydrogen bond on the DNA base pairs and derive, within a tight binding analytical band folding approach, an intrinsic Rashba coupling which should dictate the order of the spin active effects in the chiral-induced spin selectivity effect.	Hydrogen	78-86	spindlin 1	Homo sapiens	250-254
31521069-2	2019	In general, secondary structures of peptides and proteins are stabilized by C6 (delta-turn), C7 (gamma-turn), C10 (beta-turn), C13 (alpha-turn), and C15 (pi-turn) hydrogen-bonded rings formed through inter-residue interactions.	Hydrogen	163-171	placenta associated 8	Homo sapiens	149-152
23661516-7	2013	RESULTS: The results showed that hydrogen-rich saline reduced cell counts and levels of cytokines IL-4, IL-5, IL-13 and TNF-alpha in BALF.	Hydrogen	33-41	interleukin 4	Mus musculus	98-102
10223287-3	1999	When combined with the CHARMM 19 polar hydrogen energy function, it provides an effective energy function (EEF1) for proteins in solution.	Hydrogen	39-47	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	107-111
23661516-7	2013	RESULTS: The results showed that hydrogen-rich saline reduced cell counts and levels of cytokines IL-4, IL-5, IL-13 and TNF-alpha in BALF.	Hydrogen	33-41	interleukin 5	Mus musculus	104-108
10212197-4	1999	In arylsulfatase A and N-acetylgalactosamine 4-sulfatase this formylglycine was found to form the active site together with a divalent cation and a number of polar residues, tightly interconnected by a net of hydrogen bonds.	Hydrogen	209-217	arylsulfatase B	Homo sapiens	23-56
31772697-8	2019	Interestingly, three of the four compounds showed the formation of hydrogen bonds with amino acid residues lying in the capsid binding region of the PreS1 domain of LHBs, suggesting the possibility of inhibiting the viral assembly and maturation process.	Hydrogen	67-75	large envelope protein;middle envelope protein;small envelope protein	Hepatitis B virus	149-154
31772697-8	2019	Interestingly, three of the four compounds showed the formation of hydrogen bonds with amino acid residues lying in the capsid binding region of the PreS1 domain of LHBs, suggesting the possibility of inhibiting the viral assembly and maturation process.	Hydrogen	67-75	large envelope protein;middle envelope protein;small envelope protein	Hepatitis B virus	165-169
23661516-9	2013	The ratio of phospho-NF-kappaB p65 to total NF-kappaB p65 was much lower in mice treated with hydrogen-rich saline than in untreated mice.	Hydrogen	94-102	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	31-34
23661516-9	2013	The ratio of phospho-NF-kappaB p65 to total NF-kappaB p65 was much lower in mice treated with hydrogen-rich saline than in untreated mice.	Hydrogen	94-102	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	54-57
23061670-8	2013	Specifically, after electrostatic interactions attract Sox17 to DNA, Asn73, Ser99, and Trp106 form hydrogen bonds with DNA, Arg70, Lys80, Arg83, His94, and Asn95 on Sox17 undergo conformational changes and form hydrogen bonds with DNA, contributing to the electrostatic interaction between Sox17 and DNA.	Hydrogen	99-107	SRY-box transcription factor 17	Homo sapiens	55-60
31241919-11	2019	In silico studies indicated hydrogen bonding, hydrophobic, and pi-pair (pi-pi, pi-sigma, and pi-cation) interactions between the complexes and EGFR/VEGFR2 kinase receptors.	Hydrogen	28-36	kinase insert domain receptor	Homo sapiens	148-154
10097075-2	1999	The hydroxyl group of this residue forms a hydrogen bond with the C-4 oxygen atom of the FMN reaction center of the enzyme [Fox, K. M. &amp; Karplus, P. A.	Hydrogen	43-51	complement C4A (Rodgers blood group)	Homo sapiens	66-69
10047490-8	1999	The solution structure of apo-CRBP II exhibits discrete regions of backbone disorder which are most pronounced at residues 28-32, 37-38 and 73-76 in the betaE-betaF turn as evaluated by the consensus chemical shift index, the root-mean-square deviation, amide 1H exchange rates and 15N relaxation studies.	Hydrogen	260-262	retinol binding protein 2	Rattus norvegicus	30-37
23061670-8	2013	Specifically, after electrostatic interactions attract Sox17 to DNA, Asn73, Ser99, and Trp106 form hydrogen bonds with DNA, Arg70, Lys80, Arg83, His94, and Asn95 on Sox17 undergo conformational changes and form hydrogen bonds with DNA, contributing to the electrostatic interaction between Sox17 and DNA.	Hydrogen	99-107	SRY-box transcription factor 17	Homo sapiens	165-170
31299154-0	2019	Ligand Identity-Induced Generation of Enhanced Oxidative Hydrogen Atom Transfer Reactivity for a CuII2(O2 -) Complex Driven by Formation of a CuII2(-OOH) Compound with a Strong O-H Bond.	Hydrogen	57-65	immunoglobulin kappa variable 1D-39	Homo sapiens	97-105
23061670-8	2013	Specifically, after electrostatic interactions attract Sox17 to DNA, Asn73, Ser99, and Trp106 form hydrogen bonds with DNA, Arg70, Lys80, Arg83, His94, and Asn95 on Sox17 undergo conformational changes and form hydrogen bonds with DNA, contributing to the electrostatic interaction between Sox17 and DNA.	Hydrogen	99-107	SRY-box transcription factor 17	Homo sapiens	165-170
23061670-8	2013	Specifically, after electrostatic interactions attract Sox17 to DNA, Asn73, Ser99, and Trp106 form hydrogen bonds with DNA, Arg70, Lys80, Arg83, His94, and Asn95 on Sox17 undergo conformational changes and form hydrogen bonds with DNA, contributing to the electrostatic interaction between Sox17 and DNA.	Hydrogen	211-219	SRY-box transcription factor 17	Homo sapiens	55-60
31147890-0	2019	General Mechanism of Calpha-C Peptide Backbone Bond Cleavage in Matrix-Assisted Laser Desorption/Ionization In-Source Decay Mediated by Hydrogen Abstraction.	Hydrogen	136-144	carbonic anhydrase 2	Homo sapiens	21-29
10499107-0	1999	On the significance of hydrogen bonds for the discrimination between CO and O2 by myoglobin.	Hydrogen	23-31	myoglobin	Homo sapiens	82-91
23061670-8	2013	Specifically, after electrostatic interactions attract Sox17 to DNA, Asn73, Ser99, and Trp106 form hydrogen bonds with DNA, Arg70, Lys80, Arg83, His94, and Asn95 on Sox17 undergo conformational changes and form hydrogen bonds with DNA, contributing to the electrostatic interaction between Sox17 and DNA.	Hydrogen	211-219	SRY-box transcription factor 17	Homo sapiens	165-170
31147890-1	2019	Nitrogen-centered and beta-carbon-centered hydrogen-deficient peptide radicals are considered to be intermediates in the matrix-assisted laser desorption/ionization in-source decay (MALDI-ISD)-induced Calpha-C bond cleavage of peptide backbones when using an oxidizing matrix.	Hydrogen	43-51	carbonic anhydrase 2	Homo sapiens	201-209
23061670-8	2013	Specifically, after electrostatic interactions attract Sox17 to DNA, Asn73, Ser99, and Trp106 form hydrogen bonds with DNA, Arg70, Lys80, Arg83, His94, and Asn95 on Sox17 undergo conformational changes and form hydrogen bonds with DNA, contributing to the electrostatic interaction between Sox17 and DNA.	Hydrogen	211-219	SRY-box transcription factor 17	Homo sapiens	165-170
23673705-1	2013	BACKGROUND: primary distal renal tubular acidosis in children (RTA) is characterized by metabolic acidosis due to defect in urinary excretion of hydrogen (H+) in the distal tubular.	Hydrogen	145-153	MAS related GPR family member F	Homo sapiens	63-66
31370543-2	2019	We report the infrared (IR) spectrum of mono-hydrogenated corannulene (HC20H10) in solid para-hydrogen (p-H2).	Hydrogen	89-102	polyhomeotic homolog 2	Homo sapiens	104-108
31370543-6	2019	Alternative hydrogenation was achieved with H atoms produced photochemically in the infrared-induced reaction Cl + H2 (v = 1)   H + HCl in a Cl2/C20H10/p-H2 matrix.	Hydrogen	115-117	polyhomeotic homolog 2	Homo sapiens	145-156
10025663-0	1999	Receptor recognition by histidine 16 of human epidermal growth factor via hydrogen-bond donor/acceptor interactions.	Hydrogen	74-82	epidermal growth factor	Homo sapiens	46-69
10025663-8	1999	The results show that H16 of hEGF, although not essential for mitogenic activity, optimizes receptor recognition by hydrogen-bond donor/acceptor interactions and may share this feature with H18 of hTGFalpha.	Hydrogen	116-124	epidermal growth factor	Homo sapiens	29-33
23175468-0	2013	Complexes of 4-substituted phenolates with HF and HCN: energy decomposition and electronic structure analyses of hydrogen bonding.	Hydrogen	113-121	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	50-53
10939849-2	1999	The BDE"s of benzyl hydrogens (C-2 position in catechins) were found to be quite low.	Hydrogen	20-29	complement C2	Homo sapiens	31-34
31315234-0	2019	Effects of Chemical State of the Pd Species on H2 Sensing Characteristics of PdOx/SnO2 Based Chemiresistive Sensors.	Hydrogen	47-49	strawberry notch homolog 2	Homo sapiens	82-85
31308429-7	2019	The E302 amino acid residue in T1R2 was found to be the important recognition residue for polyols binding through a strongly formed hydrogen bond.	Hydrogen	132-140	taste 1 receptor member 2	Homo sapiens	31-35
23334240-10	2013	BC-1 analogues with hydrogen (BC-2) or fluorine (BC-3) at the 4" position did not form the di-quinone methides.	Hydrogen	20-28	brain cytoplasmic RNA 1	Rattus norvegicus	0-4
31386422-1	2019	We report the detection and quantification of nuclear spin incoherent scattering from hydrogen occupying interstitial sites in a thin film of vanadium.	Hydrogen	86-94	spindlin 1	Homo sapiens	54-58
31054998-4	2019	IL-17A-blocking assay and docking analysis showed that FA interacted with Trp-67, Gln-94, and Glu-95 residues of IL-17A via hydrogen bonds and consequently abolished the binding of IL-17RA to IL-17A.	Hydrogen	124-132	interleukin 17A	Mus musculus	113-119
31054998-4	2019	IL-17A-blocking assay and docking analysis showed that FA interacted with Trp-67, Gln-94, and Glu-95 residues of IL-17A via hydrogen bonds and consequently abolished the binding of IL-17RA to IL-17A.	Hydrogen	124-132	interleukin 17A	Mus musculus	113-119
23135342-2	2013	When describing conventional hydrogen bonding, researchers use the notation AH   D (where A refers to the electron acceptor and D to the donor).	Hydrogen	29-37	jagged canonical Notch ligand 1	Homo sapiens	76-82
31135002-0	2019	Spin crossover in hydrogen-bonded frameworks of FeII complexes with organodisulfonate anions.	Hydrogen	18-26	spindlin 1	Homo sapiens	0-4
22671581-3	2013	However, HCN can form hydrogen bonds with the hydrogen atoms of the benzene cation (CH(delta+)   NCH) and linear hydrogen bonding chains involving HCN   HCN interaction.	Hydrogen	22-30	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	9-12
31066431-5	2019	Hence, the improvement of hydrogen sorption kinetics for the Mg-Pr-Al composite is ascribed to the inhibiting role of Pr3Al11 in crystallite growth as well as the catalytic effect of PrH3/PrH2 on hydrogen sorption.	Hydrogen	26-34	proline rich protein HaeIII subfamily 2	Homo sapiens	188-192
31066431-5	2019	Hence, the improvement of hydrogen sorption kinetics for the Mg-Pr-Al composite is ascribed to the inhibiting role of Pr3Al11 in crystallite growth as well as the catalytic effect of PrH3/PrH2 on hydrogen sorption.	Hydrogen	196-204	proline rich protein HaeIII subfamily 2	Homo sapiens	188-192
26588744-1	2013	The low-frequency fundamentals together with the high-frequency modes, responsible for hydrogen bonding (OH/NH stretching modes), were analyzed to correlate the intensities with the hydrogen-bond strengths/binding energies of the formic acid and formamide dimers using Moller-Plesset second-order perturbation (MP2) and coupled cluster computations with explicit anharmonicity corrections.	Hydrogen	182-190	tryptase pseudogene 1	Homo sapiens	311-314
31090757-5	2019	A plausible binding mode of Hg2+ ions with compound 4 has been proposed based on 1H NMR titration, a high-resolution mass spectrometry (HRMS) study and a density functional theory (DFT) study along with the Job"s plot analysis.	Hydrogen	81-83	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	28-31
23343354-9	2013	This value is exceptionally low for a transition metal hydride, and implies that the reaction 2 [Cr-H]   2 [Cr( )] + H(2) is exergonic (DeltaG = -9.0(8) kcal mol(-1)).	Hydrogen	117-121	corticotropin releasing hormone	Homo sapiens	97-101
30851224-2	2019	Abstraction of bis-allylic hydrogen atoms is the rate-limiting step of PUFA autoxidation, which is inhibited by replacing bis-allylic hydrogens with deuterium atoms (D-PUFAs).	Hydrogen	27-35	pumilio RNA binding family member 3	Homo sapiens	71-75
30851224-2	2019	Abstraction of bis-allylic hydrogen atoms is the rate-limiting step of PUFA autoxidation, which is inhibited by replacing bis-allylic hydrogens with deuterium atoms (D-PUFAs).	Hydrogen	134-143	pumilio RNA binding family member 3	Homo sapiens	71-75
22955424-0	2013	A B3LYP and MP2(full) theoretical investigation into the strength of the C-NO(2) bond upon the formation of the intermolecular hydrogen-bonding interaction between HF and the nitro group of nitrotriazole or its methyl derivatives.	Hydrogen	127-135	tryptase pseudogene 1	Homo sapiens	12-15
31159410-2	2019	In the DN hydrogel system, P(AAc-co-Am) polymers form a network through the ionic coordinates between -COO- and Fe3+ and hydrogen bonding between -COOH and -CONH2, while another network is fabricated by the complexation between PVA and borax.	Hydrogen	121-129	glycine-N-acyltransferase	Homo sapiens	29-32
22955424-1	2013	The changes of bond dissociation energy (BDE) in the C-NO(2) bond and nitro group charge upon the formation of the intermolecular hydrogen-bonding interaction between HF and the nitro group of 14 kinds of nitrotriazoles or methyl derivatives were investigated using the B3LYP and MP2(full) methods with the 6-311++G**, 6-311++G(2df,2p) and aug-cc-pVTZ basis sets.	Hydrogen	130-138	tryptase pseudogene 1	Homo sapiens	280-283
30810552-0	2019	Hot electron effects during reactive scattering of H2 from Ag(111): assessing the sensitivity to initial conditions, coupling magnitude, and electronic temperature.	Hydrogen	51-53	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
30810552-5	2019	Using molecular dynamics simulations with electronic friction, we systematically study the effect of hot electrons on measurable state-to-state scattering probabilities of molecular hydrogen from a (111) surface of silver.	Hydrogen	182-190	alcohol dehydrogenase iron containing 1	Homo sapiens	101-104
23214953-0	2013	Analysis of 15N-1H NMR relaxation in proteins by a combined experimental and molecular dynamics simulation approach: picosecond-nanosecond dynamics of the Rho GTPase binding domain of plexin-B1 in the dimeric state indicates allosteric pathways.	Hydrogen	16-18	plexin B1	Homo sapiens	184-193
31034230-5	2019	This 1H-19F distance experiment, termed 2D heteronuclear single-quantum coherence rotational-echo double-resonance (HSQC-REDOR), is demonstrated on the singly fluorinated model protein, GB1.	Hydrogen	5-7	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	186-189
31034230-7	2019	Combining these 1H-19F distance restraints with 13C-19F distances and chemical shifts, we calculated a GB1 structure with a backbone root-mean-square deviation of 1.73 A from the high-resolution structure.	Hydrogen	16-18	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	103-106
23201273-4	2013	Despite the presence of apparently base-specific hydrogen bonds, Pot1pC is able to bind a wide range of ssDNA sequences with thermodynamic equivalence.	Hydrogen	49-57	protection of telomeres 1	Homo sapiens	65-69
30734813-4	2019	Different steady state absorption and emission properties of ZnPPIX incorporated in hCygb and hNgb are consistent with distinct hydrogen bonding interactions between ZnPPIX and the globin matrix.	Hydrogen	128-136	neuroglobin	Homo sapiens	94-98
23359864-2	2013	Heparan sulfatase 1 (HSulf-1) and heparan sulfatase 2 (HSulf-2) are two important 6-O endosulfatases which remove or edit 6-O sulfate residues of N-glucosamine present on highly sulfated HS.	Hydrogen	21-23	sulfatase 2	Homo sapiens	42-53
30884075-0	2019	A Low-Spin Three-Coordinate Cobalt(I) Complex and Its Reactivity toward H2 and Silane.	Hydrogen	72-74	spindlin 1	Homo sapiens	6-10
30884075-3	2019	At this low-spin cobalt(I) site, homolysis of H-H and Si-H bonds preferentially occurs via bimolecular hydrogen atom transfer instead of two-electron oxidative addition.	Hydrogen	103-111	spindlin 1	Homo sapiens	12-16
23359864-2	2013	Heparan sulfatase 1 (HSulf-1) and heparan sulfatase 2 (HSulf-2) are two important 6-O endosulfatases which remove or edit 6-O sulfate residues of N-glucosamine present on highly sulfated HS.	Hydrogen	21-23	sulfatase 2	Homo sapiens	55-62
31066555-7	2019	On the basis of DFT calculations, this ligand-promoted hydrolysis is caused by strong hydrogen bonds forming between Gluc- and Mg(H2O)62+.	Hydrogen	86-94	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	117-121
23733669-8	2013	Hydrogen bond pattern in alpha helices and beta sheet was recorded in IRS-1, IRS-2 and IRS-6.	Hydrogen	0-8	insulin receptor substrate 1	Homo sapiens	70-75
31384814-7	2019	The molecular docking showed that the strong hydrogen bonding and arene-cation interactions are responsible for the binding between NS3 and 1,4-benzothiazine derivatives, which provides a new dimension for potent drug design for ZIKV.	Hydrogen	45-53	KRAS proto-oncogene, GTPase	Homo sapiens	132-135
23733669-8	2013	Hydrogen bond pattern in alpha helices and beta sheet was recorded in IRS-1, IRS-2 and IRS-6.	Hydrogen	0-8	insulin receptor substrate 2	Homo sapiens	77-82
31017710-1	2019	Quantum sieving of hydrogen isotopes is experimentally studied in isostructural hexagonal metal-organic frameworks having 1-D channels, named IFP-1, -3, -4 and -7.	Hydrogen	19-27	tripartite motif containing 34	Homo sapiens	142-162
23733669-8	2013	Hydrogen bond pattern in alpha helices and beta sheet was recorded in IRS-1, IRS-2 and IRS-6.	Hydrogen	0-8	docking protein 5	Homo sapiens	87-92
30951745-6	2019	Meanwhile, CIH-induced endoplasmic reticulum stress was decreased by H2 as the expressions of CHOP, caspase-12, and GRP78 were down-regulated.	Hydrogen	69-71	caspase 12	Rattus norvegicus	100-110
24148794-0	2013	Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages.	Hydrogen	68-76	heme oxygenase 1	Homo sapiens	0-16
30951745-6	2019	Meanwhile, CIH-induced endoplasmic reticulum stress was decreased by H2 as the expressions of CHOP, caspase-12, and GRP78 were down-regulated.	Hydrogen	69-71	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	116-121
30951745-8	2019	Inhibition of mTOR may be involved in the upregulation of autophagy by H2.	Hydrogen	71-73	mechanistic target of rapamycin kinase	Rattus norvegicus	14-18
24148794-2	2013	In the present study, we investigated whether heme oxygenase-1 (HO-1) contributes to the anti-inflammatory effect of H2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.	Hydrogen	117-119	heme oxygenase 1	Homo sapiens	46-62
24148794-2	2013	In the present study, we investigated whether heme oxygenase-1 (HO-1) contributes to the anti-inflammatory effect of H2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.	Hydrogen	117-119	heme oxygenase 1	Homo sapiens	64-68
23640117-1	2013	Distal renal tubular acidosis (dRTA) or RTA type I is characterised by reduced H+&amp;nbsp;hydrogen ions and ammonium urinary excretion.	Hydrogen	91-99	MAS related GPR family member F	Homo sapiens	32-35
31026003-0	2019	1H-Detected quadrupolar spin-lattice relaxation measurements under magic-angle spinning solid-state NMR.	Hydrogen	0-2	spindlin 1	Homo sapiens	24-28
23824069-7	2013	Hydrogen deuterium exchange mass spectrometry shows that the p84 adaptor subunit interacts with the p110gamma helical domain, and reveals an unexpected mechanism of PI3Kgamma regulation.	Hydrogen	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	100-109
30986073-1	2019	A highly active Mn(I) catalyst based on a nonsymmetric PN3-ligand scaffold for the N-alkylation of amines with alcohols utilizing the borrowing hydrogen methodology is reported.	Hydrogen	144-152	sodium voltage-gated channel alpha subunit 10	Homo sapiens	55-58
23824069-7	2013	Hydrogen deuterium exchange mass spectrometry shows that the p84 adaptor subunit interacts with the p110gamma helical domain, and reveals an unexpected mechanism of PI3Kgamma regulation.	Hydrogen	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	165-174
30772592-8	2019	Second, at low doses, Fe3+ exhibited a lower ability to promote hydrogen generation and simultaneous Cr(VI) removal than Al3+.	Hydrogen	64-72	l(2)FE3	Drosophila melanogaster	22-25
23427531-0	2012	[Rovibrational state distributions of H2 in collisional energy transfer between NaK (6(1)sigma(+)) and H2].	Hydrogen	38-40	TANK binding kinase 1	Homo sapiens	80-83
30735837-7	2019	Moreover, hydrogen reduced the expression of p53, p21 and p16 and the number of blue-green precipitations in the retinas of NaIO3 mice as assessed by SA-beta-gal staining.	Hydrogen	10-18	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	50-53
30885432-5	2019	Here, we have generated a range of Prx mutants with either a decreased or knocked out ability to stack, and used both imaging and solution studies to show that Prx stacks through electrostatic interactions that are stabilised by a hydrogen bonding network.	Hydrogen	231-239	peroxiredoxin 3	Homo sapiens	160-163
23427531-1	2012	The electronic to rovibrational energy transfer between the high-lying 6(1)sigma(+) state of NaK and H2 was investigated.	Hydrogen	101-103	TANK binding kinase 1	Homo sapiens	93-96
31013316-9	2019	This experiment showed that the effect of drinking large volumes of hydrogen-rich water was not significantly different from that of normal water, in terms of preventing an increase in the size of cysts in PCK rats.	Hydrogen	68-76	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	206-209
23427531-5	2012	The scanned CARS spectra reveal that during E-V, R energy transfer processes H2 molecules are produced at v = 1, 2 and 3 levels.	Hydrogen	77-79	nibrin	Homo sapiens	103-120
23427531-13	2012	The H2 molecules produced by energy transfer process were populated by 26% at the v = 1 level, 21% at v = 2 and 53% at v = 3.	Hydrogen	4-6	nibrin	Homo sapiens	99-107
23072436-3	2012	The endo/endo isomer is the most productive isomer due to the two protons being sufficiently close to the nickel to proceed readily to the transition state to form/cleave H(2).	Hydrogen	171-175	mannosidase endo-alpha	Homo sapiens	4-8
30945711-8	2019	For the HF2- group, the 19F and 1H MAS NMR spinning sideband profiles reveal the geometry of a linear centrosymmetric three-spin system with an H-F bond distance of 1.14 A.	Hydrogen	32-34	complement factor H	Homo sapiens	8-11
23072436-3	2012	The endo/endo isomer is the most productive isomer due to the two protons being sufficiently close to the nickel to proceed readily to the transition state to form/cleave H(2).	Hydrogen	171-175	mannosidase endo-alpha	Homo sapiens	9-13
31130755-2	2019	In this synthetic sequence, deprotection of the Boc and methyl ester groups proved challenging, due to replacement of deuterium with hydrogen.	Hydrogen	133-141	BOC cell adhesion associated, oncogene regulated	Homo sapiens	48-51
23072436-7	2012	In hydrogen oxidation, deprotonation of the sterically hindered endo position by an external base may lead to slow catalytic turnover.	Hydrogen	3-11	mannosidase endo-alpha	Homo sapiens	64-68
23072436-8	2012	For hydrogen production catalysts, the limited accessibility of the endo position can result in the preferential formation of the exo protonated isomers, which must undergo one or more isomerization steps to generate the catalytically productive endo protonated isomer.	Hydrogen	4-12	mannosidase endo-alpha	Homo sapiens	68-72
23072436-8	2012	For hydrogen production catalysts, the limited accessibility of the endo position can result in the preferential formation of the exo protonated isomers, which must undergo one or more isomerization steps to generate the catalytically productive endo protonated isomer.	Hydrogen	4-12	mannosidase endo-alpha	Homo sapiens	246-250
22863419-1	2012	Discovered 50 years ago as a hydrogen donor for the reduction of ribonucleotides, thioredoxin is currently recognized as a protein central to the regulation of multiple processes in the cell.	Hydrogen	29-37	thioredoxin	Homo sapiens	82-93
30954055-1	2019	The interaction of atomic and molecular hydrogen with actinide dioxide (AnO2, An = U, Np, Pu) (111) surfaces has been investigated by DFT+U, where noncollinear 3k antiferromagnetic behaviour and spin-orbit interactions are considered.	Hydrogen	40-48	anoctamin 2	Homo sapiens	72-76
30954055-7	2019	The recombination of hydrogen ions on the AnO2 (111) surfaces is favoured over hydroxide formation.	Hydrogen	21-29	anoctamin 2	Homo sapiens	42-46
30899930-8	2019	Therefore, the VHT can meet the two primary conditions of a photocatalyst for water splitting to generate H2 in SnX and O2 in SnX2.	Hydrogen	106-108	sorting nexin 2	Homo sapiens	126-130
30474821-0	2019	1H, 15N, 13C resonance assignment of the human CD44 cytoplasmic tail (669-742).	Hydrogen	0-2	CD44 molecule (Indian blood group)	Homo sapiens	47-51
23401959-3	2012	The role of ATPase pumps of tonoplast and plasmalemma in the transport of hydrogen ions increases during further development.	Hydrogen	74-82	ATPase	Zea mays	12-18
30798456-0	2019	NMR 1H,13C, 15N resonance assignment of the G12C mutant of human K-Ras bound to GppNHp.	Hydrogen	4-6	KRAS proto-oncogene, GTPase	Homo sapiens	65-70
30798456-6	2019	Here we report 1HN, 15N, and 13C backbone and 1H, 13C side-chain resonance assignments for the 19.3 kDa (aa 1-169) human K-Ras protein harboring an oncogenic G12C mutation in the active GppNHp-bound form (K-RasG12C-GppNHp), using heteronuclear, multidimensional NMR spectroscopy at 298K.	Hydrogen	15-17	KRAS proto-oncogene, GTPase	Homo sapiens	121-126
30686752-7	2019	Docking simulations also implied that 6 interacted with hMAO-A at Phe208 and with hMAO-B at Ile199 by carbon hydrogen bondings.	Hydrogen	109-117	monoamine oxidase B	Homo sapiens	82-88
9837932-0	1998	Solution conformation of the synthetic bovine proenkephalin-A209-237 by 1H NMR spectroscopy.	Hydrogen	72-74	proenkephalin	Bos taurus	46-59
22936607-3	2012	Using NMR chemical shift, 15N relaxation, and amide hydrogen exchange measurements, we demonstrate that the Pointed-P2 PNT domain contains a dynamic N-terminal helix H0 appended to a core conserved five-helix bundle diagnostic of the SAM domain fold.	Hydrogen	52-60	pointed	Drosophila melanogaster	108-118
9860835-0	1998	The hydrogen-bonding network of water molecules and the peptide backbone in the region connecting Asp83, Gly120, and Glu113 in bovine rhodopsin.	Hydrogen	4-12	rhodopsin	Bos taurus	134-143
9819209-1	1998	The SH3 domain from the Fyn tyrosine kinase possesses a buried hydrogen bond between the side chains of a glutamate (Glu24) and a serine (Ser41) residue.	Hydrogen	63-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
30950403-5	2019	His135, a member of the catalytic dyad, is repositioned approximately 5.5 A from the orientation found in active C11 structures and forms a hydrogen bond to Asp180 and a pi-stacking interaction with Trp133.	Hydrogen	140-148	RNA polymerase III subunit K	Homo sapiens	113-116
30666863-3	2019	In this paper, we describe the combination of hydrogen-deuterium exchange and fast photochemical oxidation of proteins (FPOP) coupled with mass spectrometry to study the interactions of the human IgG1/FcgammaRIII complex.	Hydrogen	46-54	Fc gamma receptor IIIa	Homo sapiens	201-212
23020304-6	2012	The sequence of hydrogen bond strength was found to be HSO(4)(-) H(2)S-II &lt; HSO(4)(-) D(2)O-II &lt; HSO(4)(-) NH(4)(+)-II with the respective nu(2)-SOH at 736.7, 740.5, and 802.2 cm(-1) increasing in the same order.	Hydrogen	16-24	transcription elongation factor A1	Homo sapiens	69-73
30873321-5	2019	Detailed analysis of the STM images emphasizes the crucial role of weak intermolecular hydrogen bonding, and molecule-substrate interactions in the formation of the observed polymorphs.	Hydrogen	87-95	sulfotransferase family 1A member 3	Homo sapiens	25-28
9858764-0	1998	1H-NMR investigation of the influence of the heme orientation on functional properties of myoglobin.	Hydrogen	0-2	myoglobin	Homo sapiens	90-99
22957734-0	2012	Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin.	Hydrogen	0-8	serpin family E member 1	Homo sapiens	99-132
9798429-1	1998	Conformations of the alpha-L-Rhap(1-2)-beta-D-Glc1-OMe and beta-D-Galp(1-3)-beta-D-Glc1-OMe disaccharides and the branched title trisaccharide were examined in DMSO-d6 solution by 1H-nmr.	Hydrogen	180-182	galanin like peptide	Homo sapiens	66-70
30672926-5	2019	Of the as-prepared catalysts, HGCNF/SNG/MoS2 exhibited a good possibility to produce hydrogen as an electrocatalyst.	Hydrogen	85-93	nuclear receptor subfamily 6 group A member 1	Homo sapiens	30-35
30672926-8	2019	We believe that our novel 1-dimensional ternary HGCNF/SNG/MoS2 structure has expedited the electron pathways by reducing the resistance at interfaces among HGCNF, SNG and MoS2, to be potentially useful for the hydrogen evolution reaction.	Hydrogen	210-218	nuclear receptor subfamily 6 group A member 1	Homo sapiens	48-53
30672926-8	2019	We believe that our novel 1-dimensional ternary HGCNF/SNG/MoS2 structure has expedited the electron pathways by reducing the resistance at interfaces among HGCNF, SNG and MoS2, to be potentially useful for the hydrogen evolution reaction.	Hydrogen	210-218	nuclear receptor subfamily 6 group A member 1	Homo sapiens	156-161
22957734-3	2012	We have used hydrogen/deuterium exchange mass spectrometry to assess the inherent structural flexibility of PAI-1 and to monitor the changes induced by SMB binding.	Hydrogen	13-21	serpin family E member 1	Homo sapiens	108-113
22998332-2	2012	In this study, the superacid-promoted C-H cleavage into hydrogen and the carbenium ion was studied using density functional theory (B3LYP and M062X) and ab initio methods (MP2 and CCSD).	Hydrogen	56-64	tryptase pseudogene 1	Homo sapiens	172-175
30389513-6	2019	Furthermore, alternative conformations of Lys19, which is hydrogen-bonded to Asp21 in wild-type, were found only in the D21N mutant.	Hydrogen	58-66	beta-secretase 2	Homo sapiens	77-82
22696309-1	2012	The proton accepting and donating abilities of cyclopropenylidene (c-C(3)H(2)) on its complexation with hydrogen halides H-X (X = F, Cl, Br) are analyzed using density-functional theory with three functionals (PBE0, B3LYP, and B3LYP-D) and benchmarked against second-order Moller-Plesset (MP2) theory.	Hydrogen	104-112	tryptase pseudogene 1	Homo sapiens	289-292
30558427-7	2019	Using the H2 molecule as a chopper for STM-induced optical emission intensity, we demonstrate bunching in the plasmonic photon train in a single measurement over 6 orders of magnitude in the time domain (from microseconds to seconds) that takes only a few seconds.	Hydrogen	10-12	sulfotransferase family 1A member 3	Homo sapiens	39-42
9776086-3	1998	1H-NMR distinguished biochemical differences in regenerating muscles that were consistent with the extent of repair in three strains: mdx dystrophic mice; MyoD(-/-) mice that lack expression of the early myogenic regulatory gene MyoD; and a double-mutant mdx:MyoD(-/-) strain lacking expression of both MyoD and dystrophin.	Hydrogen	0-2	myogenic differentiation 1	Mus musculus	229-233
22917263-2	2012	Hydrogen-bonded self-assembly of TP2 in the solid state is shown to lead to voids within which the guest molecules are incorporated.	Hydrogen	0-8	transition protein 2	Homo sapiens	33-36
9776086-3	1998	1H-NMR distinguished biochemical differences in regenerating muscles that were consistent with the extent of repair in three strains: mdx dystrophic mice; MyoD(-/-) mice that lack expression of the early myogenic regulatory gene MyoD; and a double-mutant mdx:MyoD(-/-) strain lacking expression of both MyoD and dystrophin.	Hydrogen	0-2	myogenic differentiation 1	Mus musculus	229-233
9776086-3	1998	1H-NMR distinguished biochemical differences in regenerating muscles that were consistent with the extent of repair in three strains: mdx dystrophic mice; MyoD(-/-) mice that lack expression of the early myogenic regulatory gene MyoD; and a double-mutant mdx:MyoD(-/-) strain lacking expression of both MyoD and dystrophin.	Hydrogen	0-2	myogenic differentiation 1	Mus musculus	229-233
30616572-12	2019	The molecular modelling results showed that shikonin bound to the inhibitor binding pocket of Cdc25B with a favourable binding mode through hydrophobic interactions and hydrogen bonds.	Hydrogen	169-177	cell division cycle 25B	Mus musculus	94-100
22917263-4	2012	The robust association manifests in packing equivalence in all of the inclusion compounds of TP2 with the exception of the compound formed with pyridine and o-dichlorobenzene guests; in the latter, pyridine terminates the otherwise 3-dimensional hydrogen-bonded organization.	Hydrogen	246-254	transition protein 2	Homo sapiens	93-96
22917263-6	2012	The limited yet meaningful set of guests allows mimicry of the two expected patterns of molecular organization based on hydrogen bonding for both TP2 and BX in the solid state.	Hydrogen	120-128	transition protein 2	Homo sapiens	146-149
22949704-7	2012	Analysis of the kinetics suggests that Co(III)-H produces hydrogen by two competing pathways: a slower homolytic route involving two Co(III)-H species and a dominant heterolytic channel in which a highly reactive Co(II)-H transient is generated by Co(I) reduction of Co(III)-H.	Hydrogen	58-66	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	248-253
29665708-1	2019	BACKGROUND: Magnetic resonance (MR) spectroscopy (1H-MRS) has been demonstrated to be useful in grading glioma, but the utility in assessing cellular proliferation activity and prognosis correlated with the expression of minichromosome maintenance protein 2 (MCM2) has not been reported.	Hydrogen	50-52	minichromosome maintenance complex component 2	Homo sapiens	221-257
29665708-1	2019	BACKGROUND: Magnetic resonance (MR) spectroscopy (1H-MRS) has been demonstrated to be useful in grading glioma, but the utility in assessing cellular proliferation activity and prognosis correlated with the expression of minichromosome maintenance protein 2 (MCM2) has not been reported.	Hydrogen	50-52	minichromosome maintenance complex component 2	Homo sapiens	259-263
9810691-5	1998	We also found that a conformation in which the phenyl groups of the N-methylbenzamide and 3,4-dichlorophenyl moieties are close to each other through a cis-amide bond, may be favorable for showing high affinity for the NK1 receptor and that a hydrogen bond-accepting group in the spiro-substituted piperidine moiety may be crucial for exhibiting high affinity for the NK2 receptor.	Hydrogen	243-251	tachykinin receptor 1	Homo sapiens	219-231
9760164-0	1998	Monitoring the conformational flexibility of cytochrome c at low ionic strength by 1H-NMR spectroscopy.	Hydrogen	83-85	cytochrome c, somatic	Equus caballus	45-57
22544331-1	2012	Hydrogenated ZnO nanorod arrays (NRAs) grown on F-doped SnO(2) (FTO) glass substrates yield a benchmark specific hydrogen production rate of 122,500 mumol h(-1) g(-1), and exhibit excellent stability and recyclability.	Hydrogen	113-121	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	64-67
9760164-1	1998	Horse heart cytochrome c at pH 7 and low ionic strength is present as two conformers, as evidenced by 1H-NMR spectroscopy.	Hydrogen	102-104	cytochrome c, somatic	Equus caballus	12-24
30203662-8	2019	The Raman method does not require a reference sample, as both spin isomers (ortho and para) of hydrogen can be directly detected, which simplifies the procedure and eliminates some sources of error.	Hydrogen	95-103	spindlin 1	Homo sapiens	62-66
22782926-2	2012	The impetus for sLe(x) binding to E-selectin is shown to be the high degree of pre-organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture).	Hydrogen	126-134	selectin E	Homo sapiens	34-44
30470949-0	2019	Accurate and Sensitive Analytical Strategy for the Determination of Antimony: Hydrogen Assisted T-Shaped Slotted Quartz Tube-Atom Trap-Flame Atomic Absorption Spectrometry.	Hydrogen	78-86	TRAP	Homo sapiens	130-134
9680483-6	1998	In order to determine the critical interhelical interactions responsible for the molecular recognition between the c-Myc and Max LZs, the solution structure of the disulfide-linked c-Myc-Max heterodimeric LZ was solved by two-dimensional 1H-NMR techniques at 25 degreesC and pH 4.7.	Hydrogen	238-240	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	115-120
9680483-6	1998	In order to determine the critical interhelical interactions responsible for the molecular recognition between the c-Myc and Max LZs, the solution structure of the disulfide-linked c-Myc-Max heterodimeric LZ was solved by two-dimensional 1H-NMR techniques at 25 degreesC and pH 4.7.	Hydrogen	238-240	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	181-186
9749919-15	1998	One dimensional 1H NMR spectrum of Tr--&gt;E1-2 suggests that the S1 site and the two surface loops of this mutant trypsin may be disordered.	Hydrogen	16-18	RNA, U105B small nucleolar	Homo sapiens	43-47
31257315-6	2019	Antagonist binding to the VDR-LBD structure was elucidated using both crystal structure analysis and in-solution structural analyses with the small-angle X-ray scattering (SAXS)-molecular dynamics (MD) and hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS) methods.	Hydrogen	206-214	vitamin D receptor	Homo sapiens	26-29
22849963-2	2012	OBJECTIVE: The aim of the study was to investigate the relationship between 4 CSF chemokines with maraviroc exposure and cerebral metabolite ratios (CMR) measured by magnetic resonance spectroscopy (1H-MRS) in HIV-infected individuals following maraviroc intensification.	Hydrogen	199-201	colony stimulating factor 2	Homo sapiens	78-81
30714526-13	2019	Molecules bearing two hydrogen bond donor/acceptor (Hb d/a) groups at a distance of 8.5-11.5 A may form more stable complexes, interacting simultaneously with a secondary area A2.	Hydrogen	22-30	HBD	Homo sapiens	52-56
22441435-2	2012	The previously predicted ability of the methyl group of nitromethane to form hydrogen bonding with halides is now confirmed experimentally based on X-ray data of novel nitromethane solvates followed by theoretical ab initio calculations at the MP2 level of theory.	Hydrogen	77-85	tryptase pseudogene 1	Homo sapiens	244-247
30560918-3	2018	Here we report, using hydrogen/deuterium exchange, mechanistic models for dysregulated RIG-I proofreading that ultimately result in the improper recognition of cellular RNAs bearing 7-methylguanosine and N1-2"-O-methylation (Cap1) on the 5" end.	Hydrogen	22-30	DExD/H-box helicase 58	Homo sapiens	87-92
9692950-4	1998	Using 1H nuclear magnetic resonance spectroscopy, we have determined the solution structure of a synthetic N-terminal EGF-like domain (EGF1) of human FVII (residues 45-85) in the absence of Ca2+.	Hydrogen	6-8	G elongation factor mitochondrial 1	Homo sapiens	135-139
22514274-7	2012	Formation of several hydrogen bonds compensates the entropic cost of CP12 fixation and terminates the interaction mechanism that contributes to carbon assimilation control.	Hydrogen	21-29	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	69-73
9636715-0	1998	Determination of the three-dimensional solution structure of Raphanus sativus antifungal protein 1 by 1H NMR.	Hydrogen	102-104	defensin-like protein 1	Raphanus sativus	61-98
30320944-0	2018	The Chemical Properties of Hydrogen Atoms Adsorbed on M0 -Nanoparticles Suspended in Aqueous Solutions: The Case of Ag0 -NPs and Au0 -NPs Reduced by BD4.	Hydrogen	27-35	defensin beta 104A	Homo sapiens	149-152
30591849-3	2018	A hydrogen-induced phase transition from PdHbeta to PdHalpha is found to enable internal-stress plasticity (or transformation-mismatch plasticity) in nanoporous palladium, which leads to exceptionally high strains without fracture as a result of external forces.	Hydrogen	2-10	pyruvate dehydrogenase E1 subunit beta	Homo sapiens	41-48
26285620-1	2012	Myoglobin modulates the binding of diatomic molecules to its heme group via hydrogen-bonding and steric interactions with neighboring residues, and is an important benchmark for computational studies of biomolecules.	Hydrogen	76-84	myoglobin	Homo sapiens	0-9
30138906-1	2018	The induced fit docking of anilino quinoline scaffold results in the required hydrogen bonding interactions with amino acid residues in the orthosteric site of 3 Phosphoinositide dependent kinase (PDK1).	Hydrogen	78-86	pyruvate dehydrogenase kinase 1	Homo sapiens	197-201
30542474-9	2018	H2 inhalation reduced the infiltration of inflammatory cells into mucosa and lowered the levels of interleukin (IL)-5, IL-13 and monocyte chemoattractant protein-1 in serum.	Hydrogen	0-2	chemokine (C-C motif) ligand 2	Mus musculus	129-163
22434859-7	2012	Furthermore, docking studies showed that hydrogen bonding interactions of the active indenoquinoxalines with Asn152, Gln155, and Met149 of JNK3 played an important role in enzyme binding activity.	Hydrogen	41-49	mitogen-activated protein kinase 10	Homo sapiens	139-143
9535897-0	1998	Alteration of the midpoint potential and catalytic activity of the rieske iron-sulfur protein by changes of amino acids forming hydrogen bonds to the iron-sulfur cluster.	Hydrogen	128-136	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	Bos taurus	67-93
9535897-1	1998	The crystal structure of the bovine Rieske iron-sulfur protein indicates a sulfur atom (S-1) of the iron-sulfur cluster and the sulfur atom (Sgamma) of a cysteine residue that coordinates one of the iron atoms form hydrogen bonds with the hydroxyl groups of Ser-163 and Tyr-165, respectively.	Hydrogen	215-223	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	Bos taurus	36-62
9597181-3	1998	1H NMR measurements in aqueous solution together with molecular modeling studies indicated that there were conformational differences of the C-2 and C-6 side chains in this series of compounds.	Hydrogen	0-2	complement C2	Homo sapiens	141-144
22467876-6	2012	By employing molecular dynamics simulations of the EB1 interaction with a minimal CLASP2 plus-end-tracking module, we find that conserved arginine residues in CLASP2 form extensive hydrogen-bond networks with glutamate residues predominantly in the unstructured, acidic C-terminal tail of EB1.	Hydrogen	181-189	cytoplasmic linker associated protein 2	Homo sapiens	159-165
9514716-0	1998	Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.	Hydrogen	33-41	thymidylate synthetase	Homo sapiens	84-104
9490409-3	1998	The otherwise flexible amino-terminal extension of the MATalpha2 homeodomain forms a beta-hairpin that grips the MCM1 surface through parallel beta-strand hydrogen bonds and close-packed, predominantly hydrophobic, side chains.	Hydrogen	155-163	transcription factor MCM1	Saccharomyces cerevisiae S288C	113-117
22559653-9	2012	RESULTS: The sizes of lateral dose falloffs at the center of SOBP are 11.4, 8.5, and 5.9 mm for the three targets in RS, while they are 5.7, 4.8, and 4.6 mm in ES and 6.6, 5.7, and 5.0 mm in HS, respectively.	Hydrogen	191-193	sine oculis binding protein homolog	Homo sapiens	61-65
9451007-4	1998	We determined the solution structure of human CENP-B DBD RP1 by multi-dimensional 1H, 13C and 15N NMR methods.	Hydrogen	82-84	centromere protein B	Homo sapiens	46-52
22342964-8	2012	As in mammalian GDH1, in PfGDH2 the subunit-subunit interactions are mainly assisted by hydrogen bonds and hydrophobic interactions, whereas in PfGDH1 these contacts are mediated by networks of salt bridges and hydrogen bonds.	Hydrogen	88-96	glutamate dehydrogenase 1	Homo sapiens	16-20
9452314-4	1998	13C and 1H NMR spectra revealed that 13C enrichment in citrate and glutamine C-4 in the initial medium were increased in the presence of orotic acid, compared to the untreated hypoxia group but lower than control.	Hydrogen	8-10	complement C4A (Rodgers blood group)	Homo sapiens	77-80
22342964-8	2012	As in mammalian GDH1, in PfGDH2 the subunit-subunit interactions are mainly assisted by hydrogen bonds and hydrophobic interactions, whereas in PfGDH1 these contacts are mediated by networks of salt bridges and hydrogen bonds.	Hydrogen	211-219	glutamate dehydrogenase 1	Homo sapiens	16-20
22509010-8	2012	The LDLR tail assumes a unique "Hook"-like structure with a double beta-turn conformation, which is accommodated in distinctive ARH structural determinants (i.e., an extended backbone hydrogen-bonding platform, three hydrophobic helical grooves, and a hydrophobic pocket for Y(0)).	Hydrogen	184-192	low density lipoprotein receptor	Homo sapiens	4-8
9398309-1	1997	Two-dimensional heteronuclear (1H-15N) nuclear magnetic relaxation studies of dihydrofolate reductase (DHFR) from Escherichia coli have demonstrated that glycine-121 which is 19 A from the catalytic center of the enzyme has large-amplitude backbone motions on the nanosecond time scale [Epstein, D. M., Benkovic, S. J., and Wright, P. E. (1995) Biochemistry 34, 11037-11048].	Hydrogen	31-33	Dihydrofolate reductase	Escherichia coli	78-101
9398309-1	1997	Two-dimensional heteronuclear (1H-15N) nuclear magnetic relaxation studies of dihydrofolate reductase (DHFR) from Escherichia coli have demonstrated that glycine-121 which is 19 A from the catalytic center of the enzyme has large-amplitude backbone motions on the nanosecond time scale [Epstein, D. M., Benkovic, S. J., and Wright, P. E. (1995) Biochemistry 34, 11037-11048].	Hydrogen	31-33	Dihydrofolate reductase	Escherichia coli	103-107
9434109-0	1997	A 1H NMR study of structurally relevant inter-segmental hydrogen bond in cytochrome c.	Hydrogen	2-4	cytochrome c, somatic	Equus caballus	73-85
9434109-0	1997	A 1H NMR study of structurally relevant inter-segmental hydrogen bond in cytochrome c.	Hydrogen	56-64	cytochrome c, somatic	Equus caballus	73-85
22377964-1	2012	We have studied the intrinsic catalytic role of MCM-41 mesoporous silica in preferential oxidation of CO in excess H(2) (PROX).	Hydrogen	115-119	pyruvate dehydrogenase complex component X	Homo sapiens	121-125
9464857-1	1997	The classic function for thioredoxin is to act as a hydrogen donor for the enzyme ribonucleotide reductase, which is essential for DNA synthesis.	Hydrogen	52-60	thioredoxin	Homo sapiens	25-36
22425984-7	2012	The B-chain labeled peptide Eu-DTPA-(B)-H2 required solubilization in DMSO prior to carrying out binding assays, and showed lower affinity for binding to H2 relaxin receptor, RXFP1, compared to the water-soluble A-chain labeled peptide Eu-DTPA-(A)-H2.	Hydrogen	40-42	relaxin family peptide receptor 1	Homo sapiens	175-180
9394675-8	1997	CONCLUSION: Broadened 1H spectra observed after c-erbB-2 or c-Ha-ras transfection suggest changes of plasma membrane viscosity, which may be related to the oncogene expression.	Hydrogen	22-24	erb-b2 receptor tyrosine kinase 2	Mus musculus	48-56
22352965-0	2012	Localized hydration in lyophilized myoglobin by hydrogen-deuterium exchange mass spectrometry.	Hydrogen	48-56	myoglobin	Homo sapiens	35-44
15299866-1	1997	The charge-density distribution in 1H(+)-adeniniumtrichlorozinc(II) has been determined from X-ray diffraction data collected to sin theta/lambda = 1.32 A(-1) at 123 K. The electrostatic potential, isolated from the crystal lattice, and the deformation density in the nucleobase have been calculated following multipole refinements based on the rigid pseudoatom model of Stewart.	Hydrogen	35-37	embryonal Fyn-associated substrate	Homo sapiens	129-132
22715785-6	2012	The strength between caffeic acid and alpha-casein was electrostatic attraction (deltaH &lt; 0, deltaS &gt; 0), and that between beta-casein and alpha-Lactalbumin was hydrogen bonding (deltaH &lt; 0, deltaS &lt; 0).	Hydrogen	167-175	casein beta	Homo sapiens	129-140
9370470-1	1997	The detection of the 1H NMR signal of myoglobin (Mb) in tissue opens an opportunity to examine its cellular diffusion property, which is central to its purported role in facilitating oxygen transport.	Hydrogen	21-23	myoglobin	Homo sapiens	38-47
22253009-6	2012	The metal binding domains of these compounds interacted with HDAC2, and the surface recognition domains of these compounds interacted with HDAC4 through hydrogen bonding.	Hydrogen	153-161	histone deacetylase 4	Homo sapiens	139-144
9326488-2	1997	As long as the pyrimide ring size was maintained, the modifications had no effect on substrate binding, suggesting that the C17-C3 hydrogen bond observed in the X-ray structure is energetically neutral.	Hydrogen	131-139	cytokine like 1	Homo sapiens	124-127
9326366-1	1997	The hydration properties of the oxidized form of horse heart cytochrome c have been studied by 1H NMR spectroscopy.	Hydrogen	95-97	cytochrome c, somatic	Equus caballus	61-73
22822386-4	2012	Atomic model assessment of the CTSK gene revealed that the R122P mutant could disrupt hydrogen bonds binding with chondroitin 4-sulfate leading to a decrease in the collagen-degrading activity of cathepsin K.	Hydrogen	86-94	cathepsin K	Homo sapiens	31-35
9342241-0	1997	Two-dimensional 1H-NMR and CD structural analysis in a micellar medium of a bovine alphaS1-casein fragment having benzodiazepine-like properties.	Hydrogen	16-18	casein alpha s1	Bos taurus	83-97
22822386-4	2012	Atomic model assessment of the CTSK gene revealed that the R122P mutant could disrupt hydrogen bonds binding with chondroitin 4-sulfate leading to a decrease in the collagen-degrading activity of cathepsin K.	Hydrogen	86-94	cathepsin K	Homo sapiens	196-207
9315320-1	1997	Thioredoxin (Trx) is a small ubiquitous dithiol protein which together with the FAD-containing enzyme thioredoxin reductase (TR) and NADPH (the Trx system) is a hydrogen donor for ribonucleotide reductase essential for DNA synthesis and a general protein disulfide reductase involved in redox regulation.	Hydrogen	161-169	thioredoxin	Homo sapiens	0-11
22020754-9	2012	Both the degradation of the cytochrome b6 f complex which occurs in C. reinhardtii upon nitrogen starvation and lower ferredoxin amounts might create a bottleneck impeding the conversion of carbohydrate reserves into hydrogen evolution.	Hydrogen	217-225	cytochrome b	Chlamydomonas reinhardtii	28-40
9315320-1	1997	Thioredoxin (Trx) is a small ubiquitous dithiol protein which together with the FAD-containing enzyme thioredoxin reductase (TR) and NADPH (the Trx system) is a hydrogen donor for ribonucleotide reductase essential for DNA synthesis and a general protein disulfide reductase involved in redox regulation.	Hydrogen	161-169	thioredoxin	Homo sapiens	13-16
18975181-5	1997	The antitumor activity appeared to be related to the hydrogen bond between carbonyl group at C-4 and hydroxyl group at C-5, in contrast to cytotoxic action.	Hydrogen	53-61	complement C4A (Rodgers blood group)	Homo sapiens	93-96
22287271-5	2012	A correlation was observed between the E(T)(N) values of the solvent system and the photocatalytic activity of the CdS nanocrystallite, suggesting that the hydrogen-bond-donating ability and/or dipolarity/polarisability interactions of the solvent system led to the preferential formation of active surfaces/surface sites on the CdS crystals.	Hydrogen	156-164	CDP-diacylglycerol synthase 1	Homo sapiens	115-118
18975181-5	1997	The antitumor activity appeared to be related to the hydrogen bond between carbonyl group at C-4 and hydroxyl group at C-5, in contrast to cytotoxic action.	Hydrogen	53-61	complement C5	Homo sapiens	119-122
29098902-5	2018	Docking studies revealed that these compounds were well-accommodated within MAO-B and ChE active sites through stable hydrogen bonding and/or hydrophobic interactions.	Hydrogen	118-126	monoamine oxidase B	Homo sapiens	76-81
29980846-6	2018	The phosphorylation of cytoplasmic MKK4 and JNK were enhanced in the NT group and suppressed in the H2 group.	Hydrogen	100-102	mitogen activated protein kinase kinase 4	Rattus norvegicus	35-39
29980846-8	2018	CONCLUSION: H2 was observed to ameliorate IRI in the DCD liver by maintaining microcirculation, mitochondrial functions, and redox status, as well as suppressing the cytoplasmic MKK4-JNK-mediated cellular death pathway.	Hydrogen	12-14	mitogen activated protein kinase kinase 4	Rattus norvegicus	178-182
22209213-0	2012	Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice.	Hydrogen	0-8	apolipoprotein B	Mus musculus	44-60
30581542-4	2019	Experimental point mutations and molecular dynamic simulations show the S-loop not only binds gamma-GC through a salt bridge and multiple hydrogen bonds, but the residues also modulate allosteric communication in hGS.	Hydrogen	138-146	hepatocyte growth factor-regulated tyrosine kinase substrate	Homo sapiens	213-216
9214308-2	1997	The conformation of a V3 peptide of HIV-1IIIB bound to the Fab fragment of an anti-gp120 HIV neutralizing antibody, 0.5beta, was studied by 1H NMR spectroscopy.	Hydrogen	140-142	FA complementation group B	Homo sapiens	59-62
22209213-4	2012	Western blot analysis showed hydrogen treatment reduced the contents of apolipoprotein B (apoB), a major protein constituent of non-HDL in either plasma or hepatic tissues.	Hydrogen	29-37	apolipoprotein B	Mus musculus	72-88
22209213-4	2012	Western blot analysis showed hydrogen treatment reduced the contents of apolipoprotein B (apoB), a major protein constituent of non-HDL in either plasma or hepatic tissues.	Hydrogen	29-37	apolipoprotein B	Mus musculus	90-94
22365221-8	2012	Several unusual intermediates including cis-6,cis-12 18:2; cis-7,cis-12 18:2; and cis-8,cis-12 18:2, were found to accumulate in direct relation to the amount of added LeA, providing the first indications that hydrogenation of LeA by ruminal bacteria may also involve mechanisms other than hydrogen abstraction or isomerization of the cis-12 double bond.	Hydrogen	210-218	suppressor of cytokine signaling 5	Homo sapiens	40-45
9217261-7	1997	The two calcium ions of SAP are bridged by the dAMP phosphate group and five hydrogen bonds are formed between the protein and the ligand, including specific interactions made by the adenine base.	Hydrogen	77-85	amyloid P component, serum	Homo sapiens	24-27
30351099-2	2018	Hydrogen atoms, split from water, add to the phenol ring at the ortho position, generating syn and anti rotamers with respect to the hydroxyl group.	Hydrogen	0-8	synemin	Homo sapiens	91-94
30327561-5	2018	A structural comparison with the beta2AR bound to the full agonist epinephrine reveals differences in the hydrogen-bond network involving residues Ser2045.43 and Asn2936.55.	Hydrogen	106-114	adrenoceptor beta 2	Homo sapiens	33-40
9354389-18	1997	This observation suggests a difference between ACO and MCAD in the hydrogen-bonding network associated with enzyme-bound FAD.	Hydrogen	67-75	acyl-CoA dehydrogenase medium chain	Rattus norvegicus	55-59
22088435-3	2012	Experimental data indicate that the sodium/hydrogen ion exchanger isoform 4 (NHE4; Scl9a4) is a sodium/ammonia exchanger and plays a major role in this process.	Hydrogen	43-51	solute carrier family 9 (sodium/hydrogen exchanger), member 4	Mus musculus	77-81
9255948-0	1997	Sequence-specific 1H, 13C and 15N assignment of the TMP-resistant dihydrofolate reductase mutant DHFR(F98Y) in the ternary complex with TMP and NADPH.	Hydrogen	18-20	dihydrofolate reductase	Homo sapiens	97-101
30295033-6	2018	Molecular docking study suggested that IRW might activate ACE2 through interaction with the subdomain I near the active site through hydrogen bonds.	Hydrogen	133-141	angiotensin I converting enzyme 2	Rattus norvegicus	58-62
22037183-8	2012	We show that in the folate-GNMT complexes with the native enzyme, two folate molecules establish three and four hydrogen bonds with the protein.	Hydrogen	112-120	glycine N-methyltransferase	Rattus norvegicus	27-31
30059190-5	2018	The prerequisites for preserving hyperpolarization upon separation of the two hydrogen atoms of p-H2 are demonstrated by theoretical examinations of the boundary conditions for the hyperpolarization experiments in accordance with the OneH-PHIP theory.	Hydrogen	78-86	polyhomeotic homolog 2	Homo sapiens	96-100
30281023-4	2018	Surprisingly, hydrogen-deuterium exchange shows that surfaces of D1, D2.2 and D3 closest to the 3-fold axis are more dynamic than exposed surfaces.	Hydrogen	14-22	RAB3D, member RAS oncogene family	Homo sapiens	69-73
11671683-2	1997	Density functional theory (B3LYP, BLYP) and ab initio (HF, MP2, and QCISD(T)) methods support the hypothesis that transition state structures for the addition of cyclopropene to butadiene is stabilized through interactions between the hydrogen of cyclopropene and the pi-bond of butadiene.	Hydrogen	235-243	tryptase pseudogene 1	Homo sapiens	59-62
22037183-9	2012	In the folate-recombinant GNMT complex only one hydrogen bond is established.	Hydrogen	48-56	glycine N-methyltransferase	Rattus norvegicus	26-30
22126259-4	2012	The MP2 (second-order perturbation theory) geometry optimizations find six dimer and five tetramer structures and allow one to see the significant highly hydrogen bonded network predicted within the HEATN system.	Hydrogen	154-162	tryptase pseudogene 1	Homo sapiens	4-7
9154931-4	1997	We have found two sequences, H2 (amino acids 683-767) and H2+12 (amino acids 683-779), from the center of domain 4 which potentiate actin-tropomyosin filament activity; i.e., their effect is opposite to caldesmon.	Hydrogen	29-31	actin, beta	Gallus gallus	132-137
9154931-7	1997	H2 and H2+12 also increase actin-tropomyosin filament velocity in the in vitro motility assay.	Hydrogen	0-2	actin, beta	Gallus gallus	27-32
29721757-0	2018	NMR 1H,13C, 15N backbone and 13C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP.	Hydrogen	4-6	KRAS proto-oncogene, GTPase	Homo sapiens	93-98
22259472-3	2012	In the crystal, N-H O hydrogen bonds link the mol-ecules into [010] C(4) chains.	Hydrogen	22-30	complement C4A (Rodgers blood group)	Homo sapiens	68-72
30099644-11	2018	Due to p.Cys299Tyr substitution hydrogen bonds are generated, which may result in conformational changes and PRPF31 protein deformity.	Hydrogen	32-40	pre-mRNA processing factor 31	Homo sapiens	109-115
30068652-7	2018	Using a molecular dynamic simulation, we observed that both gag-PTAP and ORF3-PSAP motifs bind to the same site in UEV-TSG101 by hydrogen bonding.	Hydrogen	129-137	prosaposin	Homo sapiens	78-82
30248140-7	2018	Both alpha1-AR antagonists induced significant chemical shift changes in the 1H-13C-heteronuclear single quantum correlation spectrum of CXCR4 and ACKR3 in membranes, suggesting receptor binding.	Hydrogen	77-79	C-X-C motif chemokine receptor 4	Homo sapiens	137-142
9129801-0	1997	The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints.	Hydrogen	83-91	rhodopsin	Bos taurus	36-45
9129801-1	1997	A 3D model of the transmembrane 7-alpha-bundle of rhodopsin-like G-protein-coupled receptors (GPCRs) was calculated using an iterative distance geometry refinement with an evolving system of hydrogen bonds, formed by intramembrane polar side chains in various proteins of the family and collectively applied as distance constraints.	Hydrogen	191-199	rhodopsin	Bos taurus	50-59
9092663-0	1997	NMR analysis of the hydrogen bonding interactions of the RNA-binding domains of the Drosophila sex-lethal protein with target RNA fragments with site-specific [3-15N]uridine substitutions.	Hydrogen	20-28	Sex lethal	Drosophila melanogaster	95-105
30248140-7	2018	Both alpha1-AR antagonists induced significant chemical shift changes in the 1H-13C-heteronuclear single quantum correlation spectrum of CXCR4 and ACKR3 in membranes, suggesting receptor binding.	Hydrogen	77-79	atypical chemokine receptor 3	Homo sapiens	147-152
9092663-1	1997	It has been reported that a 183 residue fragment, consisting of the two RNA-binding domains (RBD1- RBD2) of the Drosophila melanogster Sex-lethal (Sxl) protein, strongly binds an oligonucleotide of the target RNA sequence (5"-GUUUUUUUUC-3") that regulates alternative splicing, and forms four or five hydrogen bonds with the imino groups of the RNA.	Hydrogen	301-309	Sex lethal	Drosophila melanogaster	135-145
21967481-7	2012	Molecular docking studies reveal a large and hydrophobic pocket that accommodates the Y substitution and a polar pocket that accommodates substitutions on the X position and forms hydrogen bonding interactions with MEK-1 kinase.	Hydrogen	180-188	mitogen-activated protein kinase kinase 1	Homo sapiens	215-220
9092663-1	1997	It has been reported that a 183 residue fragment, consisting of the two RNA-binding domains (RBD1- RBD2) of the Drosophila melanogster Sex-lethal (Sxl) protein, strongly binds an oligonucleotide of the target RNA sequence (5"-GUUUUUUUUC-3") that regulates alternative splicing, and forms four or five hydrogen bonds with the imino groups of the RNA.	Hydrogen	301-309	Sex lethal	Drosophila melanogaster	147-150
9092663-2	1997	In the present study, we used site-directed mutagenesis to improve the solubility of the didomain fragment of Sxl, and confirmed that this mutant fragment forms hydrogen bonds with the target RNA in the same manner as that of the wild-type fragment.	Hydrogen	161-169	Sex lethal	Drosophila melanogaster	110-113
9065419-0	1997	Circular dichroism and 1H nuclear magnetic resonance studies on the solution and membrane structures of GAP-43 calmodulin-binding domain.	Hydrogen	23-25	growth associated protein 43	Bos taurus	104-110
29799151-2	2018	The ability of the carboxylic acids to form strong hydrogen bonds with the PIL ion pair leads to an azeotropic composition richer in the acid component.	Hydrogen	51-59	serpin family A member 2 (gene/pseudogene)	Homo sapiens	75-78
30141818-2	2018	Herein, we proposed an in situ hydrothermal method to expedite the charge transfer with enhanced photocatalytic H2 evolution rate and photodegradation activities via introducing SnO microplates into TiO2.	Hydrogen	112-114	strawberry notch homolog 2	Homo sapiens	178-181
30141818-3	2018	As compared to bare TiO2, the SnO/TiO2 heterojunction achieves remarkable 470% and 150% higher efficiency for the photocatalytic H2 evolution rate and photodegradation of rhodamine B, respectively.	Hydrogen	129-131	strawberry notch homolog 2	Homo sapiens	30-33
30141818-5	2018	Furthermore, the photocatalytic H2 evolution activities of ZnO and C3N4 can also be improved by introducing SnO via simple mechanical mixing.	Hydrogen	32-34	strawberry notch homolog 2	Homo sapiens	108-111
22099178-5	2012	cAMP response element binding protein (CREB), a positive regulator of beta2-AR transcription, was activated at 1h after isoproterenol administration, as evidenced by increased nuclear translocation and DNA binding using immunohistochemical staining and electrophoretic mobility shift assay.	Hydrogen	111-113	cAMP responsive element binding protein 1	Rattus norvegicus	0-37
30118227-4	2018	On a specific electrolyte, 1-hexyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide [C1C6Im][NTf2] in association with Li[NTf2] (1 mol L-1) and VC, we performed NOESY, {1H-7Li} HOESY correlations, and pulsed field gradient spin-echo NMR measurements, combined with molecular dynamics simulations to determine whether such an interaction/coordination between VC and Li+ ions is noticeable.	Hydrogen	175-177	nuclear transport factor 2	Homo sapiens	99-103
9151255-8	1997	One-dimensional 1H NMR spectroscopic analysis provided evidence that the EGF-like module had a well defined structure, and was able to bind calcium with an apparent Kd of 10 mM.	Hydrogen	16-18	epidermal growth factor	Homo sapiens	73-76
22099178-5	2012	cAMP response element binding protein (CREB), a positive regulator of beta2-AR transcription, was activated at 1h after isoproterenol administration, as evidenced by increased nuclear translocation and DNA binding using immunohistochemical staining and electrophoretic mobility shift assay.	Hydrogen	111-113	cAMP responsive element binding protein 1	Rattus norvegicus	39-43
30193217-4	2018	In silico analysis of the designed compounds indicated that they may form hydrogen bonds with key amino acid residues in the PPAR-gamma LBD, and thus, secure a position in the bioactive cavity in a similar fashion as does rosiglitazone and 15 d-PGJ2.	Hydrogen	74-82	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	125-135
22470975-4	2012	A maximum photoactivity was identified with TiO2 nanoparticles modified with CoP and RuP in a 2: 1 ratio in the colloidal reaction mixture: visible light irradiation yielded 600 +/- 32 micromol H2 h(-1) (g TiO2)(-1).	Hydrogen	194-196	caspase recruitment domain family member 16	Homo sapiens	77-80
22470975-5	2012	A total turnover number of 108 +/- 9 mol H2 (mol CoP)(-1), the evolution of 4340 +/- 240 micromol H2 (g TiO2)(-1) and approximately 87 micromol H2 (m2 TiO2)(-1) were observed after 10 h irradiation.	Hydrogen	41-43	caspase recruitment domain family member 16	Homo sapiens	49-52
30242358-10	2018	Structural analysis suggested that this substitution could generate a novel hydrogen bond between the mutated residue 186 and proline at residue 192, thus potentially interrupting the tertiary structure and the stability of the IFT52 protein.	Hydrogen	76-84	intraflagellar transport 52	Homo sapiens	228-233
9078278-7	1997	As a result of an analysis of structural models of the Ca2+-GD complex of PC, it is postulated that hydrogen bonds between the side chain of R15 and the functionally important Gla16 residue, as well as between the side chain of R15 and the carbonyl oxygen in the peptide bond of H10, are critical for adoption of a Ca2+-dependent conformation of the GD that allows functional phospholipid binding.	Hydrogen	100-108	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	74-76
29745030-8	2018	Molecular docking study indicated that hydrogen bonds, van der Waals, charge interactions and Pi-cation interactions all contributed to affinity between 3l and alpha-glucosidase/PTP1B.	Hydrogen	39-47	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	178-183
23353840-13	2012	This ligand orientation is in CYP1A1/1A2 further stabilized by two hydrogen bonds; one between an oxygen atom of the AAI nitro-group and the hydroxyl group of Ser122/Thr124; and the second bond between an oxygen atom of dioxolane ring of AAI and the hydroxyl group of Thr497/Thr498.	Hydrogen	67-75	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-36
29921037-7	2018	Furthermore, H2 promoted the expression of pro-healing factors (IL-22, TGF-beta, VEGF and IGF1) and inhibited the production of MMP9 in wound tissue in parallel with acceleration of cutaneous collagen synthesis.	Hydrogen	13-15	vascular endothelial growth factor A	Mus musculus	81-85
8999873-9	1997	The preference of the enzyme for donor substrates with D-threo configuration at the C-3 and C-4 positions and for alpha-hydroxylated acceptor substrates can be understood from the pattern of hydrogen bonds between enzyme and substrate.	Hydrogen	191-199	complement C4A (Rodgers blood group)	Homo sapiens	92-95
21741873-4	2012	It attributed to the increase  OH radicals concentration in the presence of CCl4 as a hydrogen atom scavenger, and the formation of some oxidizing agents such as free chlorine and chlorine-containing radicals.	Hydrogen	86-94	C-C motif chemokine ligand 4	Homo sapiens	76-80
9113724-1	1997	Based on monosaccharide analysis and 1H- and 13C-NMR spectroscopy, the following structure of the O-specific polysaccharide chain of Proteus vulgaris OX2 lipopolysaccharide (LPS), which defines the O2 specificity of Proteus, was established: [formula: see text] where L-QuiNAc is N-acetyl-L-quinovosamine (2-acetamido-2,6-dideoxy-L-glucose).	Hydrogen	37-39	CD200 antigen	Mus musculus	150-153
9209158-0	1997	1H-NMR analysis of CD3-epsilon reveals the presence of turn-helix structures around the ITAM motif in an otherwise random coil cytoplasmic tail.	Hydrogen	0-2	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	19-30
9209158-1	1997	The conformation adopted in solution by the cytoplasmic tail of CD3-epsilon has been analyzed by 1H-nmr.	Hydrogen	97-99	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	64-75
9378100-0	1997	Vibrational frequency shifts as a probe of hydrogen bonds: thermal expansion and glass transition of myoglobin in mixed solvents.	Hydrogen	43-51	myoglobin	Homo sapiens	101-110
9378100-1	1997	The contribution of hydrogen bonds to protein-solvent interactions and their impact on structural flexibility and dynamics of myoglobin are discussed.	Hydrogen	20-28	myoglobin	Homo sapiens	126-135
9378100-2	1997	The shift of vibrational peak frequencies with the temperature of myoglobin in sucrose/water and glycerol/water solutions is used to probe the expansion of the hydrogen bond network.	Hydrogen	160-168	myoglobin	Homo sapiens	66-75
9081540-1	1997	We report here the backbone 1HN, 15N, 13C alpha, 13CO, and 1H alpha NMR assignments for the catalytic domain of human fibroblast collagenase (HFC).	Hydrogen	28-30	matrix metallopeptidase 1	Homo sapiens	118-140
9081541-6	1997	We have determined the secondary structure of a representative type I domain (A71) by 15N and 1H NMR.	Hydrogen	94-96	serpent	Drosophila melanogaster	78-81
8943222-11	1996	Our data suggest that it is the ability of the Asp578 side chain to serve as a properly positioned hydrogen bond acceptor, rather than its negative charge, that is important for stabilizing the inactive state of the LHR.	Hydrogen	99-107	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	216-219
8995843-1	1996	HCN, a new 3D NMR technique for stepwise coherence transfer from 1H to 13C to 15N and reverse through direct spin couplings 1JCH and 1JCN, is presented as a method for detection and assignment of histidine and tryptophan side-chain 1H, 13C, and 15N resonances in uniformly 13C/15N-labeled proteins.	Hydrogen	65-67	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-3
8901515-6	1996	We undertook the study of the P-selectin EGF by 1H NMR to determine its structure independent of the lectin domain and to compare its structure to that of E-selectin determined crystallographically [Graves et al.	Hydrogen	48-50	selectin P	Homo sapiens	30-40
8916426-4	1996	Unimolecular loss of hydrogen atom from C-2- and C-3-protonated pyrrole cations is preceded by proton migration in the ring.	Hydrogen	21-29	complement C2	Homo sapiens	40-43
8916426-9	1996	The radicals dissociate unimolecularly by loss of hydrogen atom, which involves both direct N-H bond cleavage and isomerization to the more stable C-2 H-isomer.	Hydrogen	50-58	complement C2	Homo sapiens	147-150
8810897-0	1996	Rational modulation of the catalytic activity of A1-1 glutathione S-transferase: evidence for incorporation of an on-face (pi...HO-Ar) hydrogen bond at tyrosine-9.	Hydrogen	135-143	DXS435E	Homo sapiens	49-53
8784221-0	1996	Functional mapping of human sensorimotor cortex with 3D BOLD fMRI correlates highly with H2(15)O PET rCBF.	Hydrogen	89-91	CCAAT enhancer binding protein zeta	Homo sapiens	97-105
8812119-2	1996	Thioredoxin was first isolated as a hydrogen donor for enzymatic synthesis of deoxyribonucleotides by ribonucleotide reductase in Escherichia coli.	Hydrogen	36-44	thioredoxin	Homo sapiens	0-11
8679950-0	1996	Assignment of the helical structure in neuropeptide Y by HPLC studies of methionine replacement analogues and 1H-NMR spectroscopy.	Hydrogen	110-112	neuropeptide Y	Homo sapiens	39-53
8805562-4	1996	RESULTS: The sequence-specific 1H resonance assignments for porcine ILBP have been determined by homonuclear two-dimensional (2D) NMR spectroscopy for the apo-protein as well as for ILBP complexes with fatty acid and bile acid ligands.	Hydrogen	31-33	fatty acid binding protein 6	Rattus norvegicus	68-72
8805562-8	1996	Fast hydrogen exchange rates for the backbone amide protons of ILBP indicate that the hydrogen-bonding network of the beta sheet in ILBP is weaker than the corresponding network in rat intestinal and bovine heart FABPs.	Hydrogen	5-13	fatty acid binding protein 6	Rattus norvegicus	63-67
8805562-8	1996	Fast hydrogen exchange rates for the backbone amide protons of ILBP indicate that the hydrogen-bonding network of the beta sheet in ILBP is weaker than the corresponding network in rat intestinal and bovine heart FABPs.	Hydrogen	5-13	fatty acid binding protein 6	Rattus norvegicus	132-136
8805562-8	1996	Fast hydrogen exchange rates for the backbone amide protons of ILBP indicate that the hydrogen-bonding network of the beta sheet in ILBP is weaker than the corresponding network in rat intestinal and bovine heart FABPs.	Hydrogen	86-94	fatty acid binding protein 6	Rattus norvegicus	63-67
8805562-8	1996	Fast hydrogen exchange rates for the backbone amide protons of ILBP indicate that the hydrogen-bonding network of the beta sheet in ILBP is weaker than the corresponding network in rat intestinal and bovine heart FABPs.	Hydrogen	86-94	fatty acid binding protein 6	Rattus norvegicus	132-136
8805562-9	1996	CONCLUSIONS: The tertiary structure of ILBP is similar to that of other LBPs, but appears to be unusually flexible, with a relatively weak hydrogen-bonding network.	Hydrogen	139-147	fatty acid binding protein 6	Rattus norvegicus	39-43
8663070-9	1996	EGF and amphiregulin, both with hydrogen bond donor functionalities at their hinge, displayed markedly decreased in potency by comparison with TGFalpha.	Hydrogen	32-40	epidermal growth factor	Homo sapiens	0-3
8672425-1	1996	The conserved Asn 229 of thymidylate synthase (TS) forms a cyclic hydrogen bond network with the 3-NH and 4-O of the nucleotide substrate 2"-deoxyuridine 5"-monophosphate (dUMP).	Hydrogen	66-74	thymidylate synthetase	Homo sapiens	25-45
8636094-6	1996	The sequence-specific 1H and 15N nuclear magnetic resonance assignments of reduced Grx3 have been obtained.	Hydrogen	22-24	glutaredoxin 3	Homo sapiens	83-87
8636094-9	1996	These differences may contribute to the observed very low Kcat of Grx3 as a reductant of insulin disulfides or as a hydrogen donor for ribonucleotide reductase.	Hydrogen	116-124	glutaredoxin 3	Homo sapiens	66-70
8568901-5	1996	The self-interaction of Fab fragments of anti-anti-idiotypic mAb GH1002 through their combining sites is extremely tight and intricate, closely resembling that observed in structures of id-anti-id complexes, and comparable in terms of total contact area, charge complementarity, and number of hydrogen bonds.	Hydrogen	293-301	FA complementation group B	Homo sapiens	24-27
8720394-2	1996	The stereochemistry of a double bond at C-20(22) of ginsenoside Rh4 was characterized as (E) from a NOESY experiment in the 1H-NMR of the aglycone.	Hydrogen	124-126	Rh blood group D antigen	Homo sapiens	64-67
30133030-0	2018	Prediction of the presence of a seventh ankyrin repeat in IkappaBepsilon from homology modeling combined with hydrogen-deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	110-118	NFKB inhibitor epsilon	Homo sapiens	58-72
30091582-2	2018	Protonating CNF surface carboxylates and hydrogen-bonding CNF surface carboxyls with PSS in PEDOT/PSS generated PEDOT/PSS/CNF aerogels that were up to ten times stronger while as conductive as neat PEDOT/PSS aerogel, attributed to the transformation of PEDOT benzoid structure to the more electron transfer-preferred quinoid structure.	Hydrogen	41-49	NPHS1 adhesion molecule, nephrin	Homo sapiens	58-61
30091582-2	2018	Protonating CNF surface carboxylates and hydrogen-bonding CNF surface carboxyls with PSS in PEDOT/PSS generated PEDOT/PSS/CNF aerogels that were up to ten times stronger while as conductive as neat PEDOT/PSS aerogel, attributed to the transformation of PEDOT benzoid structure to the more electron transfer-preferred quinoid structure.	Hydrogen	41-49	NPHS1 adhesion molecule, nephrin	Homo sapiens	58-61
29852353-12	2018	The expression of Ki-67, VEGF and SMC3 were decreased when mice were treated with H2 or cis-platinum, especially for cis-platinum.	Hydrogen	82-84	antigen identified by monoclonal antibody Ki 67	Mus musculus	18-23
29852353-12	2018	The expression of Ki-67, VEGF and SMC3 were decreased when mice were treated with H2 or cis-platinum, especially for cis-platinum.	Hydrogen	82-84	vascular endothelial growth factor A	Mus musculus	25-29
29799661-8	2018	These MMMs were used for H2 /CO2 separation (at 180  C) reaching values of 207 Barrer of H2 and a H2 /CO2 selectivity of 7.7 that clearly surpassed the Robeson upper bound (corrected for this temperature).	Hydrogen	25-27	relaxin 2	Homo sapiens	89-100
29907217-17	2018	Moreover, hydrogen-rich water caused Nrf2 to enter the cell nucleus, which resulted in increases in the expression of downstream factors such as HO-1 and NQO1.	Hydrogen	10-18	heme oxygenase 1	Rattus norvegicus	145-149
30038432-4	2018	In this study, using hydrogen deuterium exchange coupled to mass spectrometry (HDX-MS), we identified regions on the beta-Klotho protein that likely participate in ligand interaction, and vice versa.	Hydrogen	21-29	klotho beta	Homo sapiens	117-128
8568826-2	1996	The derivatives with a methyl group or hydrogen at C-4 and lacking the lactone moiety were much less cytotoxic than mycophenolic acid.	Hydrogen	39-47	complement C4A (Rodgers blood group)	Homo sapiens	51-54
22024381-8	2011	FT-IR showed that PRX recrystallization in the PVP matrix followed Ostwald"s step rule, and an increase in the three factors all led to increased hydrogen bonding interaction between PRX and PVP.	Hydrogen	146-154	periaxin	Homo sapiens	183-186
29653489-8	2018	It revealed that 6/15 may contribute to the stabilization of the NGF-TrkAd5 complex by establishing several hydrophobic and hydrogen-bond interactions with NGF and TrkA, respectively.	Hydrogen	124-132	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	69-73
29921126-4	2018	In this case, the XB potential of the typically weak XB donor Cl is shown from quantum chemical calculations to be significantly enhanced by polarization via an intramolecular hydrogen bond (HB) from the adjacent hydroxyl substituent of the tyrosyl side chain, resulting in a distinctive synergistic HB-enhanced XB (or HeX-B for short) interaction.	Hydrogen	176-184	hexosaminidase subunit beta	Homo sapiens	319-324
22041941-7	2011	Evidence for ditopic hydrogen bonding complex formation was especially sought for A10 because its CH(2) chain is sufficiently long to bridge the distance between the crown ether and pyridyl N sites of E-1.	Hydrogen	21-29	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	82-85
29996803-12	2018	Furthermore, three-dimensional crystal structure analysis revealed that replacement of Leu122 with Pro122 led to the loss of two intramolecular hydrogen bonds between the residue at position 122 and Leu188 and Ala119, resulting in instability of the MMAA protein structure.	Hydrogen	144-152	metabolism of cobalamin associated A	Homo sapiens	250-254
7498539-1	1995	When monitored by 1H NMR at various pH values, most of the C-2 proton signals from 12 His residues of the isolated beta subunit of thermophilic F1-ATPase (TF1) could be separately observed.	Hydrogen	18-20	complement C2	Homo sapiens	59-62
7578227-3	1995	Analysis of fluorine T1 relaxation behavior and 19F(1H) NOE data shows that the rate constant for dissociation of the complex is 4.7 s-1, somewhat faster than is observed at pH 4.	Hydrogen	52-54	prolyl 4-hydroxylase, transmembrane	Homo sapiens	174-178
7556670-4	1995	Furthermore, we observed a hydrogen bond between the NH group of residue Ala4 and the C = O group of residue Cys1.	Hydrogen	27-35	cystin 1	Homo sapiens	109-113
29874065-3	2018	The deprotonation patterns have been determined by X-ray crystallography and 1H NMR spectroscopy and discussed in relation to the spin state of the iron(II) centers, which influences greatly the p Ka of the ligand.	Hydrogen	77-79	spindlin 1	Homo sapiens	130-134
22041941-7	2011	Evidence for ditopic hydrogen bonding complex formation was especially sought for A10 because its CH(2) chain is sufficiently long to bridge the distance between the crown ether and pyridyl N sites of E-1.	Hydrogen	21-29	small nucleolar RNA, H/ACA box 73A	Homo sapiens	201-204
22089864-2	2011	Density functional theory calculations have been carried out to explore the effect of hydrogen on the oxidation of CO in relation to the preferential oxidation of CO in the presence of excess hydrogen (PROX).	Hydrogen	86-94	pyruvate dehydrogenase complex component X	Homo sapiens	202-206
30237684-6	2018	In silico molecular docking of (1-6) into dCK revealed good interactions, where interesting hydrogen bonds were observed with the amino acid residues-Gly-28 and Ser-35-located in the highly conserved P-loop motif.	Hydrogen	92-100	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	42-45
7636872-5	1995	These results are in apparent opposition to the binding model previously proposed which suggests a hydrogen bond donor-acceptor interaction to be present in the vicinity of the C-2 substituent.	Hydrogen	99-107	complement C2	Homo sapiens	177-180
22089864-2	2011	Density functional theory calculations have been carried out to explore the effect of hydrogen on the oxidation of CO in relation to the preferential oxidation of CO in the presence of excess hydrogen (PROX).	Hydrogen	192-200	pyruvate dehydrogenase complex component X	Homo sapiens	202-206
29891674-8	2018	Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts.	Hydrogen	122-130	cytidine/uridine monophosphate kinase 1	Homo sapiens	55-58
21710636-7	2011	The values of the binding energies and equilibrium hydrogen bond distances obtained from the analytic potential energy function are also in good agreement with those obtained from MP2 calculations with the BSSE correction.	Hydrogen	51-59	tryptase pseudogene 1	Homo sapiens	180-183
7779807-4	1995	Analyses of hydrogen bonding and fluctuations from simulations at 298 and 368 K are used to explore the relative stabilities of the helices of myoglobin.	Hydrogen	12-20	myoglobin	Homo sapiens	143-152
21847469-2	2011	In comparison to the previously published HF/MM results, both B3LYP/MM and MP2/MM simulations clearly reveal stronger H(3)O(+)-water hydrogen bond interactions, which are reflected in a slightly greater compactness of the H(3)O(+) hydrate.	Hydrogen	133-141	tryptase pseudogene 1	Homo sapiens	75-78
7766824-0	1995	Conformational properties of the proline region of porcine neuropeptide Y by CD and 1H-nmr spectroscopy.	Hydrogen	84-86	neuropeptide Y	Homo sapiens	59-73
29973922-5	2018	The HdrABC complexes catalyze FBEB-dependent oxidation of H2 for the endergonic reduction of Fdx driven by the exergonic reduction of CoMS-SCoB.	Hydrogen	58-60	ferredoxin 1	Homo sapiens	93-96
29847103-0	2018	Mechanistic Insights into Homogeneous Electrocatalytic and Photocatalytic Hydrogen Evolution Catalyzed by High-Spin Ni(II) Complexes with S2N2-Type Tetradentate Ligands.	Hydrogen	74-82	spindlin 1	Homo sapiens	111-115
21854059-0	2011	Networks of ultrasmall Pd/Cr nanowires as high performance hydrogen sensors.	Hydrogen	59-67	2,4-dienoyl-CoA reductase 2	Homo sapiens	23-28
29727183-5	2018	Signaling in the overall multicomponent system was found to depend on formation of an appropriate number of dynamic intramolecular hydrogen bonds between DR4 and CII259-273, together with the positioning of the galactose moiety of CII259-273 in the DR4 binding groove.	Hydrogen	131-139	major histocompatibility complex, class II, DR beta 4	Homo sapiens	154-157
7748897-0	1995	1H-NMR and EPR studies on met-azido and met-imidazole Dolabella auricularia myoglobin.	Hydrogen	0-2	myoglobin	Homo sapiens	76-85
7748897-1	1995	Met-azido and met-imidazole forms of the myoglobin from the mollusc Dolabella auricularia have been studied by 1H-NMR and EPR spectroscopy.	Hydrogen	111-113	myoglobin	Homo sapiens	41-50
7748897-2	1995	In the mollusc myoglobin, in which His-E7 is replaced by Val, the guanidino group of Arg-E10 serves as an alternative hydrogen-bond donor to the bound ligand.	Hydrogen	118-126	myoglobin	Homo sapiens	15-24
21854059-3	2011	This study reports hydrogen sensors based on a network of ultrasmall Cr-buffered Pd (Pd/Cr) nanowires on a filtration membrane.	Hydrogen	19-27	2,4-dienoyl-CoA reductase 2	Homo sapiens	85-90
8581429-0	1995	FTIR spectral study of intramolecular hydrogen bonding in E-type of 15-keto-prostaglandins in dilute CCl4 solution: structure-activity relationships.	Hydrogen	38-46	C-C motif chemokine ligand 4	Homo sapiens	101-105
7893684-1	1995	Amide hydrogen exchange has been used to examine the structural dynamics and energetics of the interaction of a peptide corresponding to the calmodulin binding domain of smooth muscle myosin light chain kinase with calcium-saturated calmodulin.	Hydrogen	6-14	myosin light chain kinase	Homo sapiens	170-209
29902210-7	2018	The binary complex models of S100A9-S100A12 were developed using data obtained from 1H-15N HSQC NMR titrations and the HADDOCK program.	Hydrogen	84-86	S100 calcium binding protein A9	Homo sapiens	29-35
21863821-3	2011	This allowed us to model an Npm2 decamer which may be formed by hydrogen bonds between quasi-conserved residues in the interface between two pentamers.	Hydrogen	64-72	nucleophosmin/nucleoplasmin 2	Homo sapiens	28-32
29750530-9	2018	We propose that this difference is due to cooperative production of hydrogen bonds with increasing chi in the primary ammonium PILs, which does not occur in the tertiary ammonium PIL.	Hydrogen	68-76	serpin family A member 2 (gene/pseudogene)	Homo sapiens	127-130
29763324-2	2018	We focus especially on the scattering of a hydrogen atom and its resulting spin dynamics starting from an initially spin-polarized state.	Hydrogen	43-51	spindlin 1	Homo sapiens	75-79
21774556-0	2011	Nonsolvent application of ionic liquids: organo-catalysis by 1-alkyl-3-methylimidazolium cation based room-temperature ionic liquids for chemoselective N-tert-butyloxycarbonylation of amines and the influence of the C-2 hydrogen on catalytic efficiency.	Hydrogen	220-228	complement C2	Homo sapiens	216-219
29763324-2	2018	We focus especially on the scattering of a hydrogen atom and its resulting spin dynamics starting from an initially spin-polarized state.	Hydrogen	43-51	spindlin 1	Homo sapiens	116-120
29650290-0	2018	P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.	Hydrogen	108-116	KRAS proto-oncogene, GTPase	Homo sapiens	49-52
7859587-18	1995	Therapy with H2 antagonists may result in up to a twofold rise in serum gastrin levels but in man no endocrine cell hyperplasia has been recorded.	Hydrogen	13-15	gastrin	Homo sapiens	72-79
21764272-4	2011	The NGT-1h-high subjects had increased levels of ALT and GGT, but not AST, as compared with the NGT-1h-low.	Hydrogen	8-10	gamma-glutamyltransferase light chain family member 3	Homo sapiens	57-60
7811688-0	1994	A 1H-NMR determination of the solution structure of the A-chain of insulin: comparison with the crystal structure and an examination of the role of solvent.	Hydrogen	2-4	insulin	Bos taurus	67-74
7811688-1	1994	The 1H-NMR chemical shift assignments for the oxidized A-chain of bovine insulin have been determined in aqueous and 30% trifluoroethanol/water solutions.	Hydrogen	4-6	insulin	Bos taurus	73-80
7874268-3	1994	The expression of the antigen defined by H2 increased immunocytochemically on HCC-T, HCC-M, and PLC/PRF/5 during treatment with SB.	Hydrogen	41-43	heparan sulfate proteoglycan 2	Homo sapiens	96-99
29790728-10	2018	Docking results suggested that the hydroxyl group played an essential role in the binding of OH-PBDEs to GPER by forming hydrogen bond interactions.	Hydrogen	121-129	G protein-coupled estrogen receptor 1	Homo sapiens	105-109
21795053-2	2011	From X-ray analysis of these analogs with vitamin D receptor (VDR), the carboxyl groups had very unique hydrogen bonding interactions in VDR and mimicked 1alpha-hydroxy group and/or 3beta-hydroxy group of 1alpha,25-dihydroxyvitamin D(3).	Hydrogen	104-112	vitamin D receptor	Rattus norvegicus	42-60
29757223-6	2018	The results revealed that the cementite located at the grain boundaries and at the interfaces of lath ferrite served as a kind of hydrogen trap (i.e., an irreversible hydrogen trap).	Hydrogen	130-138	TRAP	Homo sapiens	139-143
29757223-6	2018	The results revealed that the cementite located at the grain boundaries and at the interfaces of lath ferrite served as a kind of hydrogen trap (i.e., an irreversible hydrogen trap).	Hydrogen	130-138	TRAP	Homo sapiens	176-180
29757223-6	2018	The results revealed that the cementite located at the grain boundaries and at the interfaces of lath ferrite served as a kind of hydrogen trap (i.e., an irreversible hydrogen trap).	Hydrogen	167-175	TRAP	Homo sapiens	139-143
29757223-6	2018	The results revealed that the cementite located at the grain boundaries and at the interfaces of lath ferrite served as a kind of hydrogen trap (i.e., an irreversible hydrogen trap).	Hydrogen	167-175	TRAP	Homo sapiens	176-180
29757223-7	2018	In addition, hydrogen was transported from ferrite to cementite via up-hill diffusion, thereby supporting the hypothesis of cementite acting as a hydrogen trap.	Hydrogen	13-21	TRAP	Homo sapiens	155-159
29757223-7	2018	In addition, hydrogen was transported from ferrite to cementite via up-hill diffusion, thereby supporting the hypothesis of cementite acting as a hydrogen trap.	Hydrogen	146-154	TRAP	Homo sapiens	155-159
7957907-0	1994	Antithrombin histidine variants 1H NMR resonance assignments and functional properties.	Hydrogen	32-34	serpin family C member 1	Homo sapiens	0-12
7966275-1	1994	A comparative study by 1H-15N shift correlation NMR spectroscopy of the Fv and Fab fragments of anti-dansyl mouse monoclonal antibody.	Hydrogen	23-25	FA complementation group B	Homo sapiens	79-82
21795053-2	2011	From X-ray analysis of these analogs with vitamin D receptor (VDR), the carboxyl groups had very unique hydrogen bonding interactions in VDR and mimicked 1alpha-hydroxy group and/or 3beta-hydroxy group of 1alpha,25-dihydroxyvitamin D(3).	Hydrogen	104-112	vitamin D receptor	Rattus norvegicus	62-65
21795053-2	2011	From X-ray analysis of these analogs with vitamin D receptor (VDR), the carboxyl groups had very unique hydrogen bonding interactions in VDR and mimicked 1alpha-hydroxy group and/or 3beta-hydroxy group of 1alpha,25-dihydroxyvitamin D(3).	Hydrogen	104-112	vitamin D receptor	Rattus norvegicus	137-140
29756037-2	2018	We investigate the substrate translocation mechanism of LeuT by measuring the solution-phase structural dynamics of the transporter in distinct functional states by hydrogen/deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	165-173	Leucine transport, high	Homo sapiens	56-60
20969484-7	2011	Moreover, the hydrogen-bonding network created by the four residues conserved in all Prx active sites stabilizes the transition state of the peroxidatic S(N)2 displacement reaction.	Hydrogen	14-22	periaxin	Homo sapiens	85-88
29569283-7	2018	Powered by a single commercial III-V triple-junction photovoltaic cell, the integrated system achieves spontaneous and efficient generation of high-purity H2 and O2 from seawater at neutral pH with a remarkable 17.9% solar-to-hydrogen efficiency.	Hydrogen	226-234	relaxin 2	Homo sapiens	155-164
21120554-5	2011	Interestingly, at the binding sites of all PPI-CYP2C9 complexes except for Lan/CYP2C9, there are hydrogen-bonding networks made of PPIs, water molecules, and some residues of 2C9.	Hydrogen	97-105	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	47-53
28503952-10	2018	Furthermore, analysis of the binding modes revealed that for the best-docked pose nearly 10 conventional hydrogen bond can occur between the MTX-EDA-PEG-EDA-HA NPs and amino acids of CD44 receptor.	Hydrogen	105-113	CD44 molecule (Indian blood group)	Homo sapiens	183-187
29580500-3	2018	Thermodynamic analysis revealed that C3G bound to beta-Lg mainly through hydrogen bonding and hydrophobic interactions, and that their binding affinity increased gradually with increasing preheating temperature at pH 6.3, whereas it decreased at pH 3.6.	Hydrogen	73-81	Rap guanine nucleotide exchange factor 1	Homo sapiens	37-40
29580500-4	2018	Hydrogen bonding and van der Waals forces played the major roles in the interaction of beta-CN with C3G, their affinity decreasing with increasing preheating temperature at both pH values.	Hydrogen	0-8	Rap guanine nucleotide exchange factor 1	Homo sapiens	100-103
29670177-6	2018	The developed coil array was successfully tested in phantom and in vivo MR experiments, showing a simplified spectral pattern and increase in signal-to-noise ratio of approximately a factor 2 between non-decoupled and 1H-decoupled spectra in a glucose phantom and the human calf muscle.	Hydrogen	218-220	transcription termination factor 2	Homo sapiens	183-191
21120554-5	2011	Interestingly, at the binding sites of all PPI-CYP2C9 complexes except for Lan/CYP2C9, there are hydrogen-bonding networks made of PPIs, water molecules, and some residues of 2C9.	Hydrogen	97-105	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	79-85
21428843-3	2011	Hs-TnT was compared with two conventional assays (Roche troponin T [fourth generation] and Beckman Coulter Accu-TnI) on admission and at two hours.	Hydrogen	0-2	troponin T1, slow skeletal type	Homo sapiens	3-6
29546757-1	2018	Amorphous molybdenum sulfide (a-MoS x) is a promising hydrogen evolution catalyst owing to its low cost and high activity.	Hydrogen	54-62	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	32-35
29509424-2	2018	The btp ligand, H3L, adopts a three-dimensional hydrogen bonding network in the crystalline state through a combination of carboxylic acid dimer and syn-anti-btp/carboxylic acid hydrogen bonding synthons.	Hydrogen	48-56	synemin	Homo sapiens	149-152
21639097-0	2011	Highly efficient visible-light-driven photocatalytic hydrogen production of CdS-cluster-decorated graphene nanosheets.	Hydrogen	53-61	CDP-diacylglycerol synthase 1	Homo sapiens	76-79
29534297-7	2018	Structural analysis indicated that the Arg87 residue is buried at an interface between CYFIP2 and WAVE1, and the Arg87 variant may disrupt hydrogen bonding, leading to structural instability and aberrant activation of the WAVE regulatory complex.	Hydrogen	139-147	cytoplasmic FMR1 interacting protein 2	Homo sapiens	87-93
29189986-0	2018	1H, 13C, and 15N chemical shift assignments of a G-quadruplex forming sequence within the KRAS proto-oncogene promoter region.	Hydrogen	0-2	KRAS proto-oncogene, GTPase	Homo sapiens	90-94
21639097-2	2011	In this study, a high efficiency of the photocatalytic H(2) production was achieved using graphene nanosheets decorated with CdS clusters as visible-light-driven photocatalysts.	Hydrogen	55-59	CDP-diacylglycerol synthase 1	Homo sapiens	125-128
21639097-4	2011	These nanosized composites reach a high H(2)-production rate of 1.12 mmol h(-1) (about 4.87 times higher than that of pure CdS nanoparticles) at graphene content of 1.0 wt % and Pt 0.5 wt % under visible-light irradiation and an apparent quantum efficiency (QE) of 22.5% at wavelength of 420 nm.	Hydrogen	40-44	CDP-diacylglycerol synthase 1	Homo sapiens	123-126
21639097-5	2011	This high photocatalytic H(2)-production activity is attributed predominantly to the presence of graphene, which serves as an electron collector and transporter to efficiently lengthen the lifetime of the photogenerated charge carriers from CdS nanoparticles.	Hydrogen	25-29	CDP-diacylglycerol synthase 1	Homo sapiens	241-244
21573838-0	2011	Hydrogen/deuterium exchange-LC-MS approach to characterize the action of heparan sulfate C5-epimerase.	Hydrogen	0-8	glucuronic acid epimerase	Homo sapiens	73-101
29475881-9	2018	Small-angle X-ray scattering and hydrogen-deuterium exchange experiments provide insights into the structure of the PINK1 catalytic domain.	Hydrogen	33-41	PTEN induced kinase 1	Homo sapiens	116-121
21253892-6	2011	The peptide/MHC/TCR interface was found to hold significant number of solvent molecules, more specifically the peptide has been found to have approximately seventeen hydrogen bonds with water molecules.	Hydrogen	166-174	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	16-19
29675775-7	2018	Formation of excited state A-T Hoogsteen bps is accompanied by changes in sugar-backbone conformation that allow the flipped syn adenine to form hydrogen-bonds with its partner thymine and this in turn results in overall kinking of the DNA toward the major groove.	Hydrogen	145-153	synemin	Homo sapiens	125-128
29350632-3	2018	Different gas flow ratios of Ar/H2 were then employed to etch the same quality of samples and it was found that etching with hydrogen starts from the point defects and grows epitaxially, which helps in confirming crystalline orientations.	Hydrogen	125-133	ADP-ribosylhydrolase like 1	Homo sapiens	29-34
21557324-10	2011	Disruption of the interhelix hydrogen bond in alphaLbeta2 via the beta2T686G mutation results in poorer association and a similar profile as alphaIIbeta3.	Hydrogen	29-37	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	141-153
21914363-7	2011	RESULTS: The minimal expressions of IL-6, p-STAT3, cyclin D1 and DNA binding activity of STAT3 were detected in OLT-1h group.	Hydrogen	116-118	signal transducer and activator of transcription 3	Rattus norvegicus	44-49
29423483-4	2018	The presence of two halide or bifluoride HF2- (F-H-F-) anions forming anion-pi interactions, respectively above and below the ligand tetrazine ring, is the leitmotiv of the [(H2L2)X2] (X = HF2, Cl, Br, I) complexes in the solid state, while hydrogen bonding between the anions and protonated morpholine ligand groups contributes to strengthen the anion-ligand interaction, in particular in the case of Cl- and Br-.	Hydrogen	241-249	complement factor H	Homo sapiens	41-44
29423483-4	2018	The presence of two halide or bifluoride HF2- (F-H-F-) anions forming anion-pi interactions, respectively above and below the ligand tetrazine ring, is the leitmotiv of the [(H2L2)X2] (X = HF2, Cl, Br, I) complexes in the solid state, while hydrogen bonding between the anions and protonated morpholine ligand groups contributes to strengthen the anion-ligand interaction, in particular in the case of Cl- and Br-.	Hydrogen	241-249	complement factor H	Homo sapiens	189-192
21914363-7	2011	RESULTS: The minimal expressions of IL-6, p-STAT3, cyclin D1 and DNA binding activity of STAT3 were detected in OLT-1h group.	Hydrogen	116-118	signal transducer and activator of transcription 3	Rattus norvegicus	89-94
21486092-3	2011	MP2/6-31+G(d,p) calculations predicted the presence of improper hydrogen bonded C-H(ax)   Y(ax) contacts of different strength in substituted cyclohexane rings.	Hydrogen	64-72	tryptase pseudogene 1	Homo sapiens	0-8
29384260-4	2018	In this architecture, the H2 and O2 production occur at different times, which eliminates the issue of gas mixing and adapts to the variable and intermittent nature of solar energy, facilitating the conversion of solar energy to hydrogen (STH).	Hydrogen	229-237	relaxin 2	Homo sapiens	26-35
29429876-3	2018	We present room temperature neutron structures of hCA II in complex with three clinical drugs that provide in-depth analysis of drug binding, including protonation states of the inhibitors, hydration water structure, and direct visualization of hydrogen-bonding networks in the enzyme"s active site.	Hydrogen	245-253	carbonic anhydrase 2	Homo sapiens	50-56
21497714-9	2011	During the same time period, the expression of CsNR2 was not affected, whereas the expression of CsNR3 decreased significantly after 1h incubation of the excised roots in both, control and salt-containing nutrient solutions.	Hydrogen	133-135	nitrate reductase [NAD(P)H]-like	Cucumis sativus	97-102
29080272-6	2018	Molecular docking and ONIOM (B3LYP/6-31 + G*:PM6:Amber) calculations revealed that the inhibitors bound to the active site of hFPPS via hydrogen-bonding interactions, hydrophobic interactions, and cation-pi interactions.	Hydrogen	136-144	farnesyl diphosphate synthase	Homo sapiens	126-131
29433089-5	2018	It is therefore expected that novel potent ligands, which have a great binding affinity for VDR, are developed by adjusting the positions of the hydroxyl groups in the derivatives in such a way as these groups form strong hydrogen bonds with VDR residues.	Hydrogen	222-230	vitamin D receptor	Homo sapiens	92-95
29433089-5	2018	It is therefore expected that novel potent ligands, which have a great binding affinity for VDR, are developed by adjusting the positions of the hydroxyl groups in the derivatives in such a way as these groups form strong hydrogen bonds with VDR residues.	Hydrogen	222-230	vitamin D receptor	Homo sapiens	242-245
21446712-3	2011	Therefore, we hypothesized that the binding of P4 and 17OHP4 to CYP21A2 restricts access of the reactive heme-oxygen complex to the C-21 hydrogen atoms, suppressing oxygenation at kinetically more favorable sites such as C-17 and C-16, which are both hydroxylated by cytochrome P450c17 (CYP17A1).	Hydrogen	137-145	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	64-71
29432020-1	2018	Signal Amplification by Reversible Exchange (SABRE) is used to switch on the latent singlet spin order of para-hydrogen (p-H2) so that it can hyperpolarize a substrate (sub = nicotinamide, nicotinate, niacin, pyrimidine, and pyrazine).	Hydrogen	106-119	polyhomeotic homolog 2	Homo sapiens	121-125
29325204-4	2018	After the cleavage of the Gly-Phe-Leu-Gly (GFLG) sequence by pericellular overexpressed cathepsin B, CTGP@DOX is dissociated and transformed from spherical nanoparticles to nanofibers due to the hydrophilic-hydrophobic conversion and hydrogen bonding interactions.	Hydrogen	234-242	cathepsin B	Homo sapiens	88-99
21446712-6	2011	Molecular dynamics simulations indicate that binding of the steroid nucleus perpendicular to the plane of the CYP21A2 heme ring limits access of the heme oxygen to the C-21 hydrogen atoms.	Hydrogen	173-181	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	110-117
21489792-4	2011	The structure-activity relationship study indicated that hydrogen, methanesulfonyl, and aminosulfonyl groups substituted at the piperidinylamino functionality provide high inhibitory activity against IKK-2.	Hydrogen	57-65	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	200-205
28285550-13	2018	Stronger hydrogen bonds and hydrophobic interaction between T4 and activity cavity of UGT1A1 than T3 contributed to stronger inhibition of T4 towards UGT1A1.	Hydrogen	9-17	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	86-92
28285550-13	2018	Stronger hydrogen bonds and hydrophobic interaction between T4 and activity cavity of UGT1A1 than T3 contributed to stronger inhibition of T4 towards UGT1A1.	Hydrogen	9-17	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	150-156
29392938-1	2018	The proton-coupled electron transfer (PCET) reaction catalyzed by soybean lipoxygenase has served as a prototype for understanding hydrogen tunneling in enzymes.	Hydrogen	131-139	linoleate 9S-lipoxygenase-4	Glycine max	74-86
21295102-8	2011	The Bax/Bcl-2 ratio increased significantly after 1h pretreatment with curcumin.	Hydrogen	50-52	BCL2 associated X, apoptosis regulator	Rattus norvegicus	4-7
29431776-2	2018	The dihydrogen rich systems such as Su(H2)40, Su-(H2)40, and Su2-(H2)40 show interaction energy (Eint) values of 51.7, 63.0 and 87.6 kcal mol-1, respectively.	Hydrogen	49-53	relaxin 2	Homo sapiens	36-41
21388959-6	2011	Comparison among the two structures and other state 1 and state 2 structures of H-Ras/M-Ras reveal two new structural features playing critical roles in state dynamics; interaction of residues 31/41 (H-Ras/M-Ras) with residues 29/39 and 30/40, which induces a conformational change of switch I favoring its interaction with the gamma-phosphate, and the hydrogen-bonding interaction of switch II with its neighboring alpha-helix, alpha3-helix, which induces a conformational change of switch II favoring its interaction with the gamma-phosphate.	Hydrogen	353-361	HRas proto-oncogene, GTPase	Homo sapiens	80-85
29281767-0	2018	One-Step Synthesis of Nb2 O5 /C/Nb2 C (MXene) Composites and Their Use as Photocatalysts for Hydrogen Evolution.	Hydrogen	93-101	contactin 5	Homo sapiens	22-25
21425467-3	2011	A nonlinear, temperature-responsive PEG(Alk) is synthesized, and is then used to form hydrogen-bonded multilayers with poly(methacrylic acid) (PMA) at pH 5.	Hydrogen	86-94	progestagen associated endometrial protein	Homo sapiens	36-39
29281767-0	2018	One-Step Synthesis of Nb2 O5 /C/Nb2 C (MXene) Composites and Their Use as Photocatalysts for Hydrogen Evolution.	Hydrogen	93-101	contactin 5	Homo sapiens	32-35
29470422-5	2018	Hits were shown to bind to the SSB-Ct-binding site using 15N-1H HSQC spectra.	Hydrogen	61-63	single-stranded DNA-binding protein	Escherichia coli	31-34
21425467-6	2011	At pH 7, by disrupting the hydrogen bonding between the polymers, PEG(Alk) LbL films and PEG(Alk) -based capsules are obtained.	Hydrogen	27-35	progestagen associated endometrial protein	Homo sapiens	66-69
28967028-1	2018	para-Hydrogen (p-H2) serves as a new host in matrix-isolation experiments for an investigation of species of astrochemical interest.	Hydrogen	0-13	polyhomeotic homolog 2	Homo sapiens	15-19
21425467-6	2011	At pH 7, by disrupting the hydrogen bonding between the polymers, PEG(Alk) LbL films and PEG(Alk) -based capsules are obtained.	Hydrogen	27-35	progestagen associated endometrial protein	Homo sapiens	89-92
21416510-5	2011	Structural considerations conducted with the c-myc quadruplex indicate that both TrisK3-NH and TrisQ stack well onto the G-quartet but in an offset position, which might be influenced by the formation of multiple hydrogen bonds with the target in the former case.	Hydrogen	213-221	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	45-50
29300467-8	2018	We speculate that the subtle changes we detect in the hydrogen-bonding network may relate to the previously reported observation that cysteine oxidation can influence Hsp70 interdomain communication.	Hydrogen	54-62	heat shock protein family A (Hsp70) member 4	Homo sapiens	167-172
29324343-5	2018	Molecular modeling studies showed that compound 12 bind in the p1 pocket of the KRas protein making interactions with the hydrophobic residues Leu56, Tyr64, Tyr71 and Thr74 and hydrogen bonds with residues Glu37 and Asp38.	Hydrogen	177-185	KRAS proto-oncogene, GTPase	Homo sapiens	80-84
20878688-0	2011	Hydrothermal synthesis of a doped Mn-Cd-S solid solution as a visible-light-driven photocatalyst for H2 evolution.	Hydrogen	101-103	CDP-diacylglycerol synthase 1	Homo sapiens	37-41
29372745-5	2018	As a result, the enhanced hydrogen production of 3D OPG-C3N4-CN reaches up to 1590 mumol h-1 g-1 when using Pt as a cocatalyst, which is about six times as much as that of the bulk g-C3N4.	Hydrogen	26-34	basic transcription factor 3 pseudogene 11	Homo sapiens	52-55
20363597-9	2011	IL-10 was significantly increased by the high fish fat group diet in relation to HS, but only the high soybean-fish fat diet increased the IL-10/IL-4 ratio (anti-inflammatory/pro-inflammatory) to levels closer to the C group and reduced DNA damage compared to the HS group (P&lt;0.05).	Hydrogen	81-83	interleukin 10	Rattus norvegicus	0-5
29339159-4	2018	Using molecular dynamics simulations we demonstrated the quantitative and qualitative changes in hydrogen bonds upon binding with GMF.	Hydrogen	97-105	glia maturation factor beta	Homo sapiens	130-133
31938167-10	2018	Cox1 haplotypes H4, H5, and cytb haplotypes H2, H3, H4, and H5 are considered newly discovered gene haplotype sequences.	Hydrogen	44-46	mitochondrially encoded cytochrome b	Homo sapiens	28-32
31938167-10	2018	Cox1 haplotypes H4, H5, and cytb haplotypes H2, H3, H4, and H5 are considered newly discovered gene haplotype sequences.	Hydrogen	52-54	mitochondrially encoded cytochrome b	Homo sapiens	28-32
31938167-10	2018	Cox1 haplotypes H4, H5, and cytb haplotypes H2, H3, H4, and H5 are considered newly discovered gene haplotype sequences.	Hydrogen	60-62	mitochondrially encoded cytochrome b	Homo sapiens	28-32
29371696-0	2018	Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88"s effects on the gut microbiota.	Hydrogen	0-8	myeloid differentiation primary response gene 88	Mus musculus	75-80
7944366-0	1994	Secretion of human epidermal growth factor (EGF) in autotrophic culture by a recombinant hydrogen-utilizing bacterium, Pseudomonas pseudoflava, carrying broad-host-range EGF secretion vector pKSEGF2.	Hydrogen	89-97	epidermal growth factor	Homo sapiens	19-42
21103475-0	2011	Effects of counterpoise correction and basis set extrapolation on the MP2 geometries of hydrogen bonded dimers of ammonia, water, and hydrogen fluoride.	Hydrogen	88-96	tryptase pseudogene 1	Homo sapiens	70-73
29371696-5	2018	Mechanistically, microarray analysis revealed that hydrogen-water administration upregulated miR-1968-5p levels, thus resulting in parallel downregulation of MyD88 expression in the small intestine after TAI exposure.	Hydrogen	51-59	myeloid differentiation primary response gene 88	Mus musculus	158-163
29456803-0	2018	Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor.	Hydrogen	95-103	KRAS proto-oncogene, GTPase	Homo sapiens	39-42
21103475-1	2011	We study the combined effects of counterpoise correction and basis set extrapolation on the second-order Moller-Plesset (MP2) geometries of three hydrogen bonded dimers, namely (NH(3))(2), (H(2)O)(2) and (HF)(2).	Hydrogen	146-154	tryptase pseudogene 1	Homo sapiens	121-124
21108948-4	2011	Hydrogen/deuterium exchange and denaturant unfolding studies of this mutant protein (Opj) have suggested the existence of a partially unfolded intermediate in its aggregation pathway.	Hydrogen	0-8	crystallin, gamma S	Mus musculus	85-88
29348627-7	2018	In silico analysis showed close (&lt;=1.7 A) polar interaction (hydrogen bond) between Glu4, Arg7, 96, 225 of nsP2 with Lys256, 206, Val367 and Phe312 of nsP1 respectively.	Hydrogen	64-72	SH2 domain containing 3A	Homo sapiens	154-158
21108949-2	2011	To gain insights into possible kinetic intermediates, we performed hydrogen/deuterium exchange of amide protons during fibril elongation with beta(2)-microglobulin (beta(2)-m) at pD=2.5, under which conditions beta(2)-m is acid denatured.	Hydrogen	67-75	beta-2-microglobulin	Homo sapiens	142-163
21108949-2	2011	To gain insights into possible kinetic intermediates, we performed hydrogen/deuterium exchange of amide protons during fibril elongation with beta(2)-microglobulin (beta(2)-m) at pD=2.5, under which conditions beta(2)-m is acid denatured.	Hydrogen	67-75	beta-2-microglobulin	Homo sapiens	142-151
29343868-2	2018	To understand galectin-13 function at the molecular level, we solved its crystal structure and discovered that its dimer is stabilized by two disulfide bridges between Cys136 and Cys138 and six hydrogen bonds involving Val135, Val137, and Gln139.	Hydrogen	194-202	galectin 13	Homo sapiens	14-25
21163258-4	2011	Collated data indicates that both binding and orientation is dictated by the phosphorylated tyrosine and an adjacent arginine forming intra-peptide hydrogen bonds and aligning unidirectionally with complementary charges in the phosphotyrosine binding pocket of c-Cbl.	Hydrogen	148-156	Cbl proto-oncogene	Homo sapiens	261-266
21047785-10	2011	Inhibition caused by Tyr(302) nitration on OASA1 activity seems to be due to a drastically reduced O-acetylserine substrate binding to the nitrated protein, and also to reduced stabilization of the pyridoxal-5"-phosphate cofactor through hydrogen bonds.	Hydrogen	238-246	O-acetylserine (thiol) lyase (OAS-TL) 	Arabidopsis thaliana	43-48
29119647-0	2018	MoB/g-C3 N4 Interface Materials as a Schottky Catalyst to Boost Hydrogen Evolution.	Hydrogen	64-72	sphingomyelin synthase 1	Homo sapiens	0-3
21117672-1	2011	Hydrogen exchange mass spectrometry (HXMS) coupled to proteolytic digestion has been used to probe the conformation of bovine beta-lactoglobulin (BLG), bovine alpha-lactalbumin (BLA), and human serum albumin (HSA) in solution and while adsorbed to the hydrophobic interaction chromatography media Phenyl Sepharose 6FF.	Hydrogen	0-8	lactalbumin alpha	Bos taurus	159-176
29205533-3	2018	Comparative study on LaH3 -graphite and GdH3 -graphite composites suggests that the enhancement factor is 3.1-3.4 Li per active H in REH3 , almost independent of the RE metal, which is evident of a hydrogen-enhanced lithium storage mechanism.	Hydrogen	198-206	lysophosphatidic acid receptor 6	Homo sapiens	21-25
29763919-15	2018	The expression levels of Cox8b, Cox6a2, Cox7a1, Hspb7, and Atp2a1 were inhibited by hydrogen treatment.	Hydrogen	84-92	cytochrome c oxidase subunit 7A1	Mus musculus	40-46
29763919-19	2018	Cox8b, Cox6a2, Cox7a1, Hspb7, and Atp2a1 were identified as potential target genes of hydrogen treatment.	Hydrogen	86-94	cytochrome c oxidase subunit 7A1	Mus musculus	15-21
7944366-0	1994	Secretion of human epidermal growth factor (EGF) in autotrophic culture by a recombinant hydrogen-utilizing bacterium, Pseudomonas pseudoflava, carrying broad-host-range EGF secretion vector pKSEGF2.	Hydrogen	89-97	epidermal growth factor	Homo sapiens	44-47
7944366-5	1994	In these transconjugated hydrogen-utilizing bacteria, P. pseudoflava carrying pKSEGF2 grew autotrophically and secreted EGF, confirmed by Western blot (immunoblot) analysis, into the culture medium constitutively.	Hydrogen	25-33	epidermal growth factor	Homo sapiens	81-84
7824522-1	1994	The hydrogen exchange (HX) rates of the slowest peptide group NH hydrogens in oxidized cytochrome c (equine) are controlled by the transient global unfolding equilibrium.	Hydrogen	4-12	cytochrome c, somatic	Equus caballus	87-99
7824522-1	1994	The hydrogen exchange (HX) rates of the slowest peptide group NH hydrogens in oxidized cytochrome c (equine) are controlled by the transient global unfolding equilibrium.	Hydrogen	65-74	cytochrome c, somatic	Equus caballus	87-99
7824523-1	1994	The exchange kinetics for the slowly exchanging amide hydrogens in three defensins, rabbit NP-2, rabbit NP-5, and human HNP-1, have been measured over a range of pH at 25 degrees C using 1D and 2D NMR methods.	Hydrogen	54-63	HNP1	Homo sapiens	120-125
29359676-7	2018	The top compound, lead 4exibited a binding energy of -10.02 Kcal/mol and formed three hydrogen bonds with the lipid binding C2 domain of the cPLA2 protein.	Hydrogen	86-94	phospholipase A2 group IVA	Homo sapiens	141-146
20690173-6	2011	Furthermore, from the PDAR-based QSAR models we concluded that the core motif of peptides, particularly the electrostatic property, hydrophobicity, and hydrogen bond at residue positions P3, P2, and/or P0, contribute significantly to the hAmph SH3 domain-peptide binding, whereas two ends of the peptides, such as P6, P4, P-4, and P5, only play a secondary role in the binding.	Hydrogen	152-160	solute carrier family 10 member 4	Homo sapiens	322-325
28811203-5	2018	Molecular docking study and analysis of small- molecule interaction with PTP1B all showed BPN inhibited PTP1B activity via binding to the catalytic site through hydrogen bonds.	Hydrogen	161-169	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	73-78
15299386-4	1994	Addition of 2.5-3 molar equivalents of H(2)SO(4) to isoionic lysozyme decreases the pH value to 9-8 and allows crystallization to take place.	Hydrogen	39-42	lysozyme C-3	Sus scrofa	61-69
21522689-4	2010	In the crystal, mol-ecules are connected to each other by inter-molecular N-H O hydrogen bonds along the b axis, generating a C(4) chain.	Hydrogen	80-88	complement C4A (Rodgers blood group)	Homo sapiens	126-130
7512379-1	1994	Backbone dynamics of the ligand- (FK506-) bound protein FKBP-12 (107 amino acids) have been examined using 15N relaxation data derived from inverse-detected two-dimensional 1H-15N NMR spectra.	Hydrogen	173-175	FKBP prolyl isomerase 1A pseudogene 1	Homo sapiens	56-63
28811203-5	2018	Molecular docking study and analysis of small- molecule interaction with PTP1B all showed BPN inhibited PTP1B activity via binding to the catalytic site through hydrogen bonds.	Hydrogen	161-169	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	104-109
29223566-4	2018	A 1H-detected 2D 1H-15N correlation SSNMR spectrum for ~27 nmol of a uniformly 13C- and 15N-labeled GB1 protein sample in microcrystalline form was acquired in only 9 s with 50% non-uniform sampling and short recycle delays of 100 ms. Additional data suggests that it is now feasible to detect as little as 1 nmol of the protein in 5.9 h by 1H-detected 2D 1H-15N SSNMR at a nominal signal-to-noise ratio of five.	Hydrogen	2-4	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	100-103
29223566-4	2018	A 1H-detected 2D 1H-15N correlation SSNMR spectrum for ~27 nmol of a uniformly 13C- and 15N-labeled GB1 protein sample in microcrystalline form was acquired in only 9 s with 50% non-uniform sampling and short recycle delays of 100 ms. Additional data suggests that it is now feasible to detect as little as 1 nmol of the protein in 5.9 h by 1H-detected 2D 1H-15N SSNMR at a nominal signal-to-noise ratio of five.	Hydrogen	17-19	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	100-103
29223566-4	2018	A 1H-detected 2D 1H-15N correlation SSNMR spectrum for ~27 nmol of a uniformly 13C- and 15N-labeled GB1 protein sample in microcrystalline form was acquired in only 9 s with 50% non-uniform sampling and short recycle delays of 100 ms. Additional data suggests that it is now feasible to detect as little as 1 nmol of the protein in 5.9 h by 1H-detected 2D 1H-15N SSNMR at a nominal signal-to-noise ratio of five.	Hydrogen	17-19	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	100-103
29223566-4	2018	A 1H-detected 2D 1H-15N correlation SSNMR spectrum for ~27 nmol of a uniformly 13C- and 15N-labeled GB1 protein sample in microcrystalline form was acquired in only 9 s with 50% non-uniform sampling and short recycle delays of 100 ms. Additional data suggests that it is now feasible to detect as little as 1 nmol of the protein in 5.9 h by 1H-detected 2D 1H-15N SSNMR at a nominal signal-to-noise ratio of five.	Hydrogen	17-19	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	100-103
21151569-11	2010	Molecular modeling predicted that the mutated residue would form hydrogen bond with the adjacent residues, potentially affecting the structure and formation of an active complex with leptin receptor within that region.	Hydrogen	65-73	leptin	Mus musculus	183-189
29344293-11	2018	Furthermore, molecular docking evidence revealed that ligustrazine bound to PPARgamma in a unique double-molecule manner via hydrogen bonding with the residues Ser289 and Ser342.	Hydrogen	125-133	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	76-85
20951036-0	2010	Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones as MCH-1 antagonists for the treatment of obesity.	Hydrogen	54-56	sarcosinemia autosomal recessive	Mus musculus	14-17
29262362-3	2017	Here, we describe 1H-detected magic angle spinning solid-state NMR studies of monomeric IL-8 (1-66) bound to full-length and truncated constructs of CXCR1 in phospholipid bilayers under physiological conditions.	Hydrogen	18-20	C-X-C motif chemokine receptor 1	Homo sapiens	149-154
8114094-0	1994	The role of a conserved internal water molecule and its associated hydrogen bond network in cytochrome c. High resolution three-dimensional structures for the N52I and N52I-Y67F yeast iso-1-cytochrome c variants have been completed in both oxidation states.	Hydrogen	67-75	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	184-189
8307031-1	1994	1H two-dimensional NMR spectroscopy has been applied to the oxidized form of cytochrome c 551 from Rhodocyclus gelatinosus, which is paramagnetic with S = 1/2.	Hydrogen	0-2	cytochrome c, somatic	Equus caballus	77-89
7779404-8	1994	The arginine at position 41 is the most critical residue and its full hydrogen-bonding capacity is needed for strong binding of EGF/TGF-alpha to the EGF-receptor.	Hydrogen	70-78	epidermal growth factor	Homo sapiens	128-131
7779404-8	1994	The arginine at position 41 is the most critical residue and its full hydrogen-bonding capacity is needed for strong binding of EGF/TGF-alpha to the EGF-receptor.	Hydrogen	70-78	epidermal growth factor	Homo sapiens	149-152
7779406-5	1994	The 1H chemical shifts of the 12 conserved aromatic residues and the pKa values of the five conserved histidine residues in MH35 and human LIF are very similar.	Hydrogen	4-6	LIF interleukin 6 family cytokine	Homo sapiens	139-142
20919750-7	2010	The beta hairpin conformation with Turn(9-6) and four hydrogen bonds (HB(4-11), HB(6-9), HB(9-6) and HB(11-4)) is the lowest free energy state in the simulation at pH = 7.0.	Hydrogen	54-62	keratin 86	Homo sapiens	80-86
8108245-0	1993	[Evaluation of fatty liver changes and fatty degeneration in liver tumors by 1H-MRS].	Hydrogen	77-79	sterile alpha motif domain containing 11	Homo sapiens	80-83
8108245-1	1993	This study assesses the ability of 1H-MR spectroscopy (MRS) to evaluate fatty liver changes and fatty degeneration in liver tumors using the STEAM sequence, 1 cm3 VOI, TR/TE/excitations = 600/34/32, during breath-holding.	Hydrogen	35-37	sterile alpha motif domain containing 11	Homo sapiens	55-58
29150397-2	2017	The sequential combination of in silico fragment hopping and fragment linking based on S160/Y161/A162 hinge residues hydrogen bonding interactions leads to the identification of novel 1H-benzo[d]imidazol-2-yl)-1H-indazol class of Phosphoinositide-Dependent Kinase-1 (PDK1) inhibitors.	Hydrogen	117-125	pyruvate dehydrogenase kinase 1	Homo sapiens	230-265
29150397-2	2017	The sequential combination of in silico fragment hopping and fragment linking based on S160/Y161/A162 hinge residues hydrogen bonding interactions leads to the identification of novel 1H-benzo[d]imidazol-2-yl)-1H-indazol class of Phosphoinositide-Dependent Kinase-1 (PDK1) inhibitors.	Hydrogen	117-125	pyruvate dehydrogenase kinase 1	Homo sapiens	267-271
20945356-1	2010	The solution dynamics of an enzyme acid-beta-glucocerebrosidase (GCase) probed at a physiologically relevant (lysosomal) pH by hydrogen/deuterium exchange mass spectrometry (HDX-MS) reveals very uneven distribution of backbone amide protection across the polypeptide chain.	Hydrogen	127-135	glucosylceramidase beta	Homo sapiens	40-63
28618071-9	2017	In vivo, alphaGalCer or OCH administration to the lung resulted in enhanced mucus secretion, inflammatory cell recruitment, and cytokine production in H2 R-deficient or famotidine-treated animals, while dimaprit dampened the lung iNKT cell response to alphaGalCer.	Hydrogen	151-153	ochre	Mus musculus	24-27
28608965-8	2017	We demonstrated that exogenous H2 S facilitated Parkin recruited by PINK1 by immunoprecipitation and immunostaining assays and then ubiquitylated mitofusin 2 (Mfn2), which illuminated the mechanism of exogenous H2 S on mitophagy.	Hydrogen	31-33	PTEN induced kinase 1	Homo sapiens	68-73
28608965-8	2017	We demonstrated that exogenous H2 S facilitated Parkin recruited by PINK1 by immunoprecipitation and immunostaining assays and then ubiquitylated mitofusin 2 (Mfn2), which illuminated the mechanism of exogenous H2 S on mitophagy.	Hydrogen	31-33	mitofusin 2	Homo sapiens	146-157
8241174-0	1993	Unfolding of the molten globule state of alpha-lactalbumin studied by 1H NMR.	Hydrogen	70-72	lactalbumin alpha	Bos taurus	41-58
8241174-1	1993	The urea-induced unfolding of the molten globule state of bovine alpha-lactalbumin was investigated by 1H nuclear magnetic resonance.	Hydrogen	103-105	lactalbumin alpha	Bos taurus	65-82
28608965-8	2017	We demonstrated that exogenous H2 S facilitated Parkin recruited by PINK1 by immunoprecipitation and immunostaining assays and then ubiquitylated mitofusin 2 (Mfn2), which illuminated the mechanism of exogenous H2 S on mitophagy.	Hydrogen	31-33	mitofusin 2	Homo sapiens	159-163
8144352-7	1993	The beta 37 residue is an alpha 1 beta 2 contact site and the substitution of the tryptophan for a glycine would be expected to result in a destabilization of the deoxy-hemoglobin form because of the reduced number of hydrogen bonds, salt bridges and van der Waal contacts between the alpha 1 and beta 2 chains.	Hydrogen	218-226	adrenoceptor alpha 1D	Homo sapiens	26-33
20977251-1	2010	MP2 calculations with cc-pVTZ basis set were used to analyze intermolecular interactions in F(3)CX   HMgH   Y and F(3)CX   Y   HMgH triads (X = Cl, Br; Y = HCN, and HNC) which are connecting with three kinds of unusual weak interactions, namely halogen-hydride, dihydrogen, and sigma-hole.	Hydrogen	262-272	tryptase pseudogene 1	Homo sapiens	0-3
28289968-4	2017	PROCEDURES: [3H]LRRK2-IN-1 was prepared with high radiochemical purity (&gt;99 %) and a specific activity of 41 Ci/mmol via tritium/hydrogen (T/H) exchange using Crabtree"s catalyst.	Hydrogen	132-140	inversion, Chr 17	Mus musculus	22-26
28610393-2	2017	The as-prepared S,N-GQD/P25 composites exhibited excellent photocatalytic hydrogen generation activities, with a significantly extended light absorption range and superior durability without loading any noble metal cocatalyst.	Hydrogen	74-82	tubulin polymerization promoting protein	Homo sapiens	24-27
20923173-12	2010	In all Mg2+ binding motifs, a key hydrogen bond was identified between a magnesium-bound water and Cys1p, bridging the two metallic binding sites and, thereby, reducing the equilibrium distance between the reacting atoms of FPP Cys1p.	Hydrogen	34-42	cystin 1	Homo sapiens	99-104
27931154-8	2017	Celastrol and 25 analogues showed strong binding affinity with IKKbeta as evidenced by strong hydrogen-bonding interactions with critical active site residues.	Hydrogen	94-102	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	63-70
20923173-12	2010	In all Mg2+ binding motifs, a key hydrogen bond was identified between a magnesium-bound water and Cys1p, bridging the two metallic binding sites and, thereby, reducing the equilibrium distance between the reacting atoms of FPP Cys1p.	Hydrogen	34-42	cystin 1	Homo sapiens	228-233
20856955-1	2010	MP2/6-311++G(d,p) calculations have been carried out to investigate the conformation, protonation and the hydrogen bonding interactions with water of several halogenated ethers (CH(3)OCH(2)Cl, CH(2)ClOCH(2)Cl, CH(3)OCHCl(2), CHFClOCHF(2)).	Hydrogen	106-114	tryptase pseudogene 1	Homo sapiens	0-3
29048896-2	2017	Mixtures of C5H8 and Cl2 were codeposited in p-H2 at 3.2 K, followed by irradiation with ultraviolet light at 365 nm to induce the photodissociation of Cl2 and the subsequent reaction of the Cl atoms with C5H8.	Hydrogen	47-49	endogenous retrovirus group W member 5	Homo sapiens	21-24
29134216-3	2017	In particular, the formation of C[double bond, length as m-dash]OD2O-PIL hydrogen bonds was preferred in P(OEGMA-co-BVIm[SCN]) during the phase transition process considering the interaction of IL-D2O associations and C[double bond, length as m-dash]O groups.	Hydrogen	73-81	serpin family A member 2 (gene/pseudogene)	Homo sapiens	69-72
20949524-2	2010	Gilfillan et al.2008] reported mutations in SLC9A6, the gene encoding the sodium/hydrogen exchanger NHE6, in the family first reported and in three others.	Hydrogen	81-89	solute carrier family 9 member A6	Homo sapiens	44-50
28789975-6	2017	At 1h, peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer binding protein (C/EBP)alpha, and microsomal triglyceride transfer protein (MTTP) mRNAs were reduced in NPY-injected chicks whereas NPY receptor 1 (NPYR1) was increased.	Hydrogen	3-5	microsomal triglyceride transfer protein	Homo sapiens	118-158
20949524-2	2010	Gilfillan et al.2008] reported mutations in SLC9A6, the gene encoding the sodium/hydrogen exchanger NHE6, in the family first reported and in three others.	Hydrogen	81-89	solute carrier family 9 member A6	Homo sapiens	100-104
20836998-1	2010	Deuteration at C-4 and C-5 of sphingosine was achieved via a hydrogen-deuterium exchange reaction of a beta-ketophosphonate intermediate catalyzed by ND4Cl in D2O/tetrahydrofuran.	Hydrogen	61-69	complement C4A (Rodgers blood group)	Homo sapiens	15-18
28634060-5	2017	Molecular docking simulation revealed the binding energy of acacetin for MAO-B (-44.2kcal/mol) was greater than its energy for MAO-A (-27.0kcal/mol), and that the Cys172 residue of MAO-B was important for hydrogen bonding with acacetin.	Hydrogen	205-213	monoamine oxidase B	Homo sapiens	73-78
20836998-1	2010	Deuteration at C-4 and C-5 of sphingosine was achieved via a hydrogen-deuterium exchange reaction of a beta-ketophosphonate intermediate catalyzed by ND4Cl in D2O/tetrahydrofuran.	Hydrogen	61-69	complement C5	Homo sapiens	23-26
20717596-7	2010	Application is made to the computation of excited states of the HCN-(4)He complex and to the computation of tunneling splittings in the hydrogen bonded HCl-HCl complex.	Hydrogen	136-144	hyperpolarization activated cyclic nucleotide gated potassium channel 4	Homo sapiens	64-70
20818631-5	2010	Under low hydrogen pressure (&lt;15 atm), the reaction rate proportionally increased with the hydrogen pressure.	Hydrogen	10-18	ATM serine/threonine kinase	Homo sapiens	36-39
20818631-5	2010	Under low hydrogen pressure (&lt;15 atm), the reaction rate proportionally increased with the hydrogen pressure.	Hydrogen	94-102	ATM serine/threonine kinase	Homo sapiens	36-39
20842126-0	2010	1H nuclear magnetic resonance spectroscopy characterisation of metabolic phenotypes in the medulloblastoma of the SMO transgenic mice.	Hydrogen	0-2	smoothened, frizzled class receptor	Mus musculus	114-117
29126075-3	2017	The 1H spin-lattice relaxation times of the acid protons decrease with increase in the content of ammonium ions.	Hydrogen	4-6	spindlin 1	Homo sapiens	7-11
29126075-7	2017	Spin diffusion between the acid and the ammonium protons averages partially the 1H relaxation of the acid and the ammonium protons at the MAS rate of 8 kHz.	Hydrogen	80-82	spindlin 1	Homo sapiens	0-4
29126075-14	2017	Using those parameters, the effect of ammonium ions on the 1H spin-lattice relaxation can be predicted.	Hydrogen	59-61	spindlin 1	Homo sapiens	62-66
29126075-15	2017	The 1H spin-lattice relaxation is a sensitive tool to study the distribution of ammonium ions in solids.	Hydrogen	4-6	spindlin 1	Homo sapiens	7-11
28972756-6	2017	The other vibrational frequencies for HOSO are reduced relative to the corresponding frequencies in SO2, H2SO4, and the HOS radical making the infrared features of syn-HOSO likely red-shifted in mixed spectral observation, where oxygen, hydrogen, and sulfur are all found.	Hydrogen	237-245	synemin	Homo sapiens	164-167
28632338-2	2017	Being weakly acidic, the CF2 H moiety can establish hydrogen-bonding interactions to improve the binding selectivity of biologically active compounds.	Hydrogen	52-60	ATPase H+ transporting accessory protein 1	Homo sapiens	25-28
28948788-0	2017	Kinetic and Spectroscopic Studies of the Reaction of CF2 with H2 in Shock Waves.	Hydrogen	62-64	ATPase H+ transporting accessory protein 1	Homo sapiens	53-56
28948788-1	2017	The reaction of CF2 with H2 was studied in shock waves by monitoring UV absorption signals.	Hydrogen	25-27	ATPase H+ transporting accessory protein 1	Homo sapiens	16-19
28948790-7	2017	Under the conditions of the described experiments, the primary dissociation CH2F2   CHF + HF is followed by the reaction CHF + HF   CF2 + H2.	Hydrogen	77-79	ATPase H+ transporting accessory protein 1	Homo sapiens	132-135
28949147-5	2017	Combined with 1H NMR chemical shift perturbations, we conclude that the SCN- ions tightly associate with the head groups and are partially buried.	Hydrogen	14-16	sorcin	Homo sapiens	72-75
28868538-6	2017	The alcoholic hydrogen of syn-vinyl alcohol is found to be the easiest to remove, requiring 84.4 kcal mol-1.	Hydrogen	14-22	synemin	Homo sapiens	26-29
29038209-2	2017	Activation of the sodium-hydrogen exchanger in the heart and vasculature (NHE1 isoform) and the kidneys (NHE3 isoform) may serve as a common mechanism that links both disorders and may underlie their interplay.	Hydrogen	25-33	solute carrier family 9 member A3	Homo sapiens	105-109
8344310-0	1993	1H-NMR study of reduced heme proteins myoglobin and cytochrome P450.	Hydrogen	0-2	myoglobin	Homo sapiens	38-47
7691290-0	1993	1H nuclear magnetic resonance determination of the membrane-bound conformation of senktide, a highly selective neurokinin B agonist.	Hydrogen	0-2	tachykinin precursor 3	Homo sapiens	111-123
7684988-1	1993	The sequential 1H and 15N assignments of the SH3 domain of human phosphatidyl inositol 3"-kinase (PI3K) were determined by a combination of homonuclear and heteronuclear NMR experiments.	Hydrogen	15-17	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	65-96
8391867-1	1993	The regulation of junctional conductance (Gi) of the major cardiac (connexin43; Cx43) and liver (connexin32; Cx32) gap junction proteins by intracellular hydrogen ion concentration (pH; pHi), as well as well as that of a truncation mutant of Cx43 (M257) with 125 amino acids deleted from the COOH terminus, was characterized in pairs of Xenopus laevis oocytes expressing homologous channels.	Hydrogen	154-162	gap junction protein beta 1 L homeolog	Xenopus laevis	97-107
8391867-1	1993	The regulation of junctional conductance (Gi) of the major cardiac (connexin43; Cx43) and liver (connexin32; Cx32) gap junction proteins by intracellular hydrogen ion concentration (pH; pHi), as well as well as that of a truncation mutant of Cx43 (M257) with 125 amino acids deleted from the COOH terminus, was characterized in pairs of Xenopus laevis oocytes expressing homologous channels.	Hydrogen	154-162	gap junction protein beta 1 L homeolog	Xenopus laevis	109-113
8387597-4	1993	Structures of the new compounds are distinguished by changes in NMR chemical shifts of 13C and 1H nuclei in the regions of C-4 and C-12.	Hydrogen	95-97	complement component 4B (Chido blood group)	Mus musculus	123-126
8097110-2	1993	This supports a deprotonation/protonation mechanism for racemization in which the breaking of the carbon-hydrogen bond at C-2 is partially rate-determining.	Hydrogen	105-113	complement C2	Homo sapiens	122-125
8097110-11	1993	It appears that cysteine-73 is responsible for the abstraction of the C-2 hydrogen from (R)-glutamate and cysteine-184 abstracts the proton from (S)-glutamate in the racemization reaction of the wild-type enzyme.	Hydrogen	74-82	complement C2	Homo sapiens	70-73
8487302-8	1993	The substitution of Glu59, which is preserved in all the determined species of parvalbumin, by Asp59 in oncomodulin seems to break a stabilizing hydrogen bond in the CD loop and render the main-chain in positions 59 to 60 somewhat unstable.	Hydrogen	145-153	oncomodulin	Rattus norvegicus	104-115
8466903-1	1993	Activation of the enediyne neocarzinostatin chromophore (NCS-Chrom) by thiol addition at C-12 generates a diradical species with radical centers at C-2 and C-6, which abstract hydrogens from deoxyribose in the minor groove of DNA.	Hydrogen	176-185	complement C2	Homo sapiens	148-151
8466903-4	1993	Further, experiments with the gamma-L-glutamyl-DL-cysteinylglycine labeled with deuterium on the alpha- or beta-carbons to the sulfur showed small amounts of internal transfer of hydrogen into C-2 of the drug from the naturally occurring L,L diastereomer only.	Hydrogen	179-187	complement C2	Homo sapiens	193-196
28858526-5	2017	In the latter case, this was ascribed to the steric bulk of the ammonium moiety disfavoring conformations in which hydrogen-bonding to the hydroxyl group results in direction of the epoxidation to the syn face.	Hydrogen	115-123	synemin	Homo sapiens	201-204
20842126-6	2010	In contrast, 1H MRS metabolite concentrations in normal appearing cerebellum of the SMO mice were not different from those in the WT mice.	Hydrogen	13-15	smoothened, frizzled class receptor	Mus musculus	84-87
20842126-7	2010	Macromolecule and lipid 1H MRS signals in SMO medulloblastomas were not different from those detected in the cerebellum of WT mice.	Hydrogen	24-26	smoothened, frizzled class receptor	Mus musculus	42-45
8466903-6	1993	In all, these various hydrogen donation sources can account for at least 70-80% of the hydrogen incorporated at C-2 of the drug under DNA damage conditions.	Hydrogen	22-30	complement C2	Homo sapiens	112-115
8466903-6	1993	In all, these various hydrogen donation sources can account for at least 70-80% of the hydrogen incorporated at C-2 of the drug under DNA damage conditions.	Hydrogen	87-95	complement C2	Homo sapiens	112-115
20842126-8	2010	The HR-MAS analysis of SMO medulloblastomas confirmed the in vivo 1H MRS metabolite profiles, and additionally revealed that phosphocholine was strongly elevated in medulloblastomas accounting for the high in vivo CCM.	Hydrogen	66-68	smoothened, frizzled class receptor	Mus musculus	23-26
28786216-3	2017	Their hydrogen-bonded 2D on-surface self-assemblies are observed under STM at the solid/liquid interface; these structures are very different to those in the bulk crystal.	Hydrogen	6-14	sulfotransferase family 1A member 3	Homo sapiens	71-74
20554199-2	2010	The CSTR was operated at an hydraulic retention time (HRT) of 3 days, and the UASB and AF reactors were operated at 1 day HRT, using mixed extreme thermophiles at 70  C. The highest hydrogen production yield of 212.0+-6.6 mL-H2/g-sugars, corresponding to a hydrogen production rate of 821.4+-25.5 mL-H2/dL was achieved with the UASB reactor.	Hydrogen	182-190	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	297-302
28786216-4	2017	Upon combining the results of STM measurements and DFT calculations, the formation mechanism of different assemblies is revealed; in particular, the critical role of hydrogen bonding in the assemblies.	Hydrogen	166-174	sulfotransferase family 1A member 3	Homo sapiens	30-33
8390883-4	1993	The present results demonstrate that the exchange rates of amide hydrogens in cytochrome c range from very rapid (k &gt; 140 h-1) to very slow (k &lt; 0.002 h-1).	Hydrogen	65-74	cytochrome c, somatic	Equus caballus	78-90
20563763-0	2010	1H, 15N and 13C assignments of an intramolecular Lmo2-LIM2/Ldb1-LID complex.	Hydrogen	0-2	LIM domain binding 1	Homo sapiens	59-63
28867612-3	2017	Here, nuclear magnetic resonance and hydrogen-deuterium exchange mass spectrometry show that BTK adopts a closed conformation in dynamic equilibrium with open, active conformations.	Hydrogen	37-45	Bruton tyrosine kinase	Homo sapiens	93-96
20443540-6	2010	MP2 predicts the C(3v) F(-)-CH(3)I and FCH(3)-I(-) ion-dipole complexes and traditional [F-CH(3)-I](-) central barrier as stationary points, as well as a C(s) hydrogen-bonded F(-)-HCH(2)I complex and a [F-HCH(2)-I](-) transition state connecting this latter complex to the F(-)-CH(3)I complex.	Hydrogen	159-167	tryptase pseudogene 1	Homo sapiens	0-3
28549396-8	2017	After noise exposure, the concentrations of IL-1, IL-6, TNF-alpha, and ICAM-1 in the cochlea of guinea pigs in the hydrogen-saturated saline group were dramatically reduced compared to those in the normal saline group.	Hydrogen	115-123	interleukin-6	Cavia porcellus	50-54
28251507-4	2017	Here we report the 1H, 15N, and 13C resonance assignments for an important regulatory domain of Cx37, the carboxyl terminus (CT; C233-V333).	Hydrogen	19-21	gap junction protein, alpha 4	Mus musculus	96-100
8382154-0	1993	1H- and 13C-NMR investigation of redox-state-dependent and temperature-dependent conformation changes in horse cytochrome c.	Hydrogen	0-2	cytochrome c, somatic	Equus caballus	111-123
8382155-0	1993	Evaluation of 13C and 1H Fermi contact shifts in horse cytochrome c.	Hydrogen	22-24	cytochrome c, somatic	Equus caballus	55-67
8386360-0	1993	Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics.	Hydrogen	62-64	corticotropin releasing hormone	Homo sapiens	28-58
8386360-1	1993	The structure of human corticotropin releasing factor (hCRF) has been determined by proton nuclear magnetic resonance (1H NMR) in a mixed-solvent system of 66% trifluoroethanol/34% H2O at pH 3.8 and 37 degrees C. Nearly complete resonance assignment was achieved by using standard two-dimensional methods.	Hydrogen	119-121	corticotropin releasing hormone	Homo sapiens	23-53
8386360-1	1993	The structure of human corticotropin releasing factor (hCRF) has been determined by proton nuclear magnetic resonance (1H NMR) in a mixed-solvent system of 66% trifluoroethanol/34% H2O at pH 3.8 and 37 degrees C. Nearly complete resonance assignment was achieved by using standard two-dimensional methods.	Hydrogen	119-121	corticotropin releasing hormone	Homo sapiens	55-59
28747437-7	2017	Intersubunit interactions involving 11 hydrogen bonds and numerous hydrophobic contacts account for stable complex formation with a buried surface area of 3094 A2 Comparative structural analysis of p59-p261C with the corresponding Polalpha complex revealed significant differences between the B-subunits and CTDs, as well as their interaction interfaces.	Hydrogen	39-47	HLA complex P5B	Homo sapiens	198-201
28682000-3	2017	In this work, we show a new approach based on para enriched hydrogen (p-H2 ) that enables the hyperpolarization of bulk water if a suitable catalytic system is employed.	Hydrogen	60-68	polyhomeotic homolog 2	Homo sapiens	70-74
26616080-6	2010	More importantly, examination of the potentials of mean force of hydrogen-bonding and charge-charge interactions demonstrates that GBSW/MS2 correctly captures the first desolvation peaks, a key signature of true MS.	Hydrogen	65-73	MS2	Homo sapiens	136-139
29057045-3	2017	Their binding affinity with MDM2 was evaluated using fluorescence polarization (FP) assay and 1H-15N two-dimensional HSQC nuclear magnetic resonance experiments.	Hydrogen	94-96	MDM2 proto-oncogene	Homo sapiens	28-32
29221146-7	2017	As underlying mechanisms, in silico and Lineweaver-Burk plot analyses exhibited that swertiajaponin may directly bind to and inhibit tyrosinase activity by forming multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase.	Hydrogen	173-181	tyrosinase	Homo sapiens	133-143
29207659-7	2017	As a mechanism underlying the BMN11-mediated anti-melanogenic effect, docking simulation showed that BMN11 can directly bind to tyrosinase by forming two hydrogen bonds with GLY281 and ASN260 residues, and via three hydrophobic interactions with VAL283, PHE264, and ALA286 residues in the tyrosinase binding pocket, and this likely contributes to its inhibitory effect on tyrosinase.	Hydrogen	154-162	tyrosinase	Homo sapiens	128-138
28525871-5	2017	The ionized groups of PFCs can form electrostatic interactions with the -NH+3 groups of Lys 15 residues in hTTR and form hydrogen bonds with the residues of hTTR.	Hydrogen	121-129	transthyretin	Homo sapiens	157-161
28737905-0	2017	Metabolism of T-2 Toxin in Farm Animals and Human In Vitro and in Chickens In Vivo Using Ultra High-Performance Liquid Chromatography- Quadrupole/Time-of-Flight Hybrid Mass Spectrometry Along with Online Hydrogen/Deuterium Exchange Technique.	Hydrogen	204-212	solute carrier family 25 member 5	Homo sapiens	14-17
28474853-1	2017	At 80 GPa, phases with the PH2 stoichiometry, which are composed of simple cubic like phosphorus layers capped with hydrogen atoms and layers of H2 molecules, are predicted to be important species contributing to the recently observed superconductivity in compressed phosphine.	Hydrogen	116-124	polyhomeotic homolog 2	Homo sapiens	27-30
28463769-0	2017	Stable hydrogen and oxygen isotopes of tap water reveal structure of the San Francisco Bay Area"s water system and adjustments during a major drought.	Hydrogen	7-15	nuclear RNA export factor 1	Homo sapiens	39-42
28654236-7	2017	Furthermore, we show that our cell can be run in reverse and operate as a H2 fuel cell, releasing the energy stored in the electrogenerated H2 and O2.	Hydrogen	74-76	relaxin 2	Homo sapiens	140-149
28648075-5	2017	Prior to catalytic evaluation, the reduction profiles of the mesoporous metal oxides were investigated by hydrogen-temperature-programmed reduction (H2-TPR) and showed that mesoporous metal oxides can be easily reduced at lower temperatures and that the immobilization of gold-palladium nanoalloy particles lowers their reduction temperatures.	Hydrogen	106-114	translocated promoter region, nuclear basket protein	Homo sapiens	152-155
28482570-6	2017	The molecular docking studies of the heteroleptic silver(I) complexes with EGFR/VEGFR2 kinase receptors show hydrophobic, pi-pi, sigma-pi and hydrogen bonding interactions.	Hydrogen	142-150	kinase insert domain receptor	Homo sapiens	80-86
29166069-2	2017	Our results suggest that the introduction of SCN- ions at the apical positions gives rise to shorter Pb-S bond lengths, more distorted octahedra, and more hydrogen bonds, which have important effects on the electronic, optical, mechanical, and piezoelectric properties in (MA)2Pb(SCN)2I2.	Hydrogen	155-163	sorcin	Homo sapiens	45-48
28346703-0	2017	Tunable GLUT-Hexose Binding and Transport via Modulation of Hexose C-3 Hydrogen-Bonding Capabilities.	Hydrogen	71-79	solute carrier family 2 member 1	Homo sapiens	8-12
28346703-0	2017	Tunable GLUT-Hexose Binding and Transport via Modulation of Hexose C-3 Hydrogen-Bonding Capabilities.	Hydrogen	71-79	complement C3	Homo sapiens	67-70
28346703-1	2017	The importance of the hydrogen bonding interactions in the GLUT-hexose binding process (GLUT=hexose transporter) has been demonstrated by studying the binding of structurally modified d-fructose analogues to GLUTs, and in one case its transport into cells.	Hydrogen	22-30	solute carrier family 2 member 1	Homo sapiens	59-63
28346703-1	2017	The importance of the hydrogen bonding interactions in the GLUT-hexose binding process (GLUT=hexose transporter) has been demonstrated by studying the binding of structurally modified d-fructose analogues to GLUTs, and in one case its transport into cells.	Hydrogen	22-30	solute carrier family 2 member 1	Homo sapiens	88-92
28346703-2	2017	The presence of a hydrogen bond donor at the C-3 position of 2,5-anhydro-d-mannitol derivatives is essential for effective binding to GLUT5 and transport into tumor cells.	Hydrogen	18-26	complement C3	Homo sapiens	45-48
28346703-3	2017	Surprisingly, installation of a group that can function only as a hydrogen bond acceptor at C-3 resulted in selective recognition by GLUT1 rather than GLUT5.	Hydrogen	66-74	complement C3	Homo sapiens	92-95
28346703-3	2017	Surprisingly, installation of a group that can function only as a hydrogen bond acceptor at C-3 resulted in selective recognition by GLUT1 rather than GLUT5.	Hydrogen	66-74	solute carrier family 2 member 1	Homo sapiens	133-138
28363579-2	2017	A successful homogeneous coating of PEDOT:PSS on cellulose nanofibers occurred by means hydrogen-bonding interactions between the hydroxyl functionalized CNF and the electronically charged PEDOT:PSS, as shown by FTIR spectra.	Hydrogen	88-96	NPHS1 adhesion molecule, nephrin	Homo sapiens	154-157
27368672-1	2017	BACKGROUND: Tenapanor (RDX5791, AZD1722), a small molecule with minimal systemic availability, is an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3).	Hydrogen	125-133	solute carrier family 9 member A3	Homo sapiens	155-159
30023646-8	2017	Residue Asn287 from L11 forms hydrogen bonding to the sulfone group of PVZB1194, whereby L11 moves inward to the alpha4/alpha6 allosteric pocket and moves away from the pocket in absence of the inhibitor.	Hydrogen	30-38	immunoglobulin kappa variable 1-6	Homo sapiens	20-23
30023646-8	2017	Residue Asn287 from L11 forms hydrogen bonding to the sulfone group of PVZB1194, whereby L11 moves inward to the alpha4/alpha6 allosteric pocket and moves away from the pocket in absence of the inhibitor.	Hydrogen	30-38	immunoglobulin kappa variable 1-6	Homo sapiens	89-92
30023646-8	2017	Residue Asn287 from L11 forms hydrogen bonding to the sulfone group of PVZB1194, whereby L11 moves inward to the alpha4/alpha6 allosteric pocket and moves away from the pocket in absence of the inhibitor.	Hydrogen	30-38	immunoglobulin binding protein 1	Homo sapiens	113-126
28443920-3	2017	It was found that for single bonded substitutions, the hydrogen transfer reaction dominates for the syn-conformers, while the OO bending reaction dominates for the anti-conformers.	Hydrogen	55-63	synemin	Homo sapiens	100-103
29250456-1	2017	Soybean lipoxygenase (SLO) is a prototype for nonadiabatic hydrogen tunneling reactions and, as such, has served as the subject of numerous theoretical studies.	Hydrogen	59-67	linoleate 9S-lipoxygenase-4	Glycine max	8-20
28244495-1	2017	OBJECTIVES: Tenapanor is a first-in-class, small-molecule inhibitor of the gastrointestinal sodium/hydrogen exchanger NHE3.	Hydrogen	99-107	solute carrier family 9 member A3	Homo sapiens	118-122
28336409-6	2017	X-ray crystallographic analysis of H3K4M derivatives bound to the LSD1 CoREST complex revealed the presence of additional hydrogen bonding between the N-terminal Ser residue of the H3 peptide derivative and LSD1.	Hydrogen	122-130	lysine demethylase 1A	Homo sapiens	66-70
28336409-6	2017	X-ray crystallographic analysis of H3K4M derivatives bound to the LSD1 CoREST complex revealed the presence of additional hydrogen bonding between the N-terminal Ser residue of the H3 peptide derivative and LSD1.	Hydrogen	122-130	lysine demethylase 1A	Homo sapiens	207-211
29353952-6	2017	Complex 1" is catalytically active in the dehydrogenation of formic acid to generate CO-free hydrogen in three consecutive runs as well as for the dehydrogenative coupling of alcohols, giving high conversions to different esters and outperforming structurally related PNN ligands lacking the NOH fragment.	Hydrogen	44-52	pinin, desmosome associated protein	Homo sapiens	268-271
28430763-11	2017	The docking study suggested that pinitol efficiently interacted with PTPN22 via Arg59, Tyr60, Leu106, and Lys138 by creating close interatomic hydrogen bonds and hydrophobic contacts.	Hydrogen	143-151	protein tyrosine phosphatase, non-receptor type 22	Rattus norvegicus	69-75
28433034-1	2017	At ambient temperature, conversion from 100% enriched para-hydrogen (p-H2; singlet state) to ortho-hydrogen (o-H2; triplet state) leads necessarily to the thermodynamic equilibrium proportions: 75% of o-H2 and 25% of p-H2.	Hydrogen	54-67	polyhomeotic homolog 2	Homo sapiens	69-73
28433034-1	2017	At ambient temperature, conversion from 100% enriched para-hydrogen (p-H2; singlet state) to ortho-hydrogen (o-H2; triplet state) leads necessarily to the thermodynamic equilibrium proportions: 75% of o-H2 and 25% of p-H2.	Hydrogen	54-67	polyhomeotic homolog 2	Homo sapiens	217-221
28433034-1	2017	At ambient temperature, conversion from 100% enriched para-hydrogen (p-H2; singlet state) to ortho-hydrogen (o-H2; triplet state) leads necessarily to the thermodynamic equilibrium proportions: 75% of o-H2 and 25% of p-H2.	Hydrogen	59-67	polyhomeotic homolog 2	Homo sapiens	69-73
28433034-1	2017	At ambient temperature, conversion from 100% enriched para-hydrogen (p-H2; singlet state) to ortho-hydrogen (o-H2; triplet state) leads necessarily to the thermodynamic equilibrium proportions: 75% of o-H2 and 25% of p-H2.	Hydrogen	59-67	polyhomeotic homolog 2	Homo sapiens	217-221
28433034-5	2017	Also, as the para ortho conversion is monitored by proton nuclear magnetic resonance (NMR) of dissolved o-H2 (p-H2 is NMR-silent), one has to account for H2 exchange between the liquid phase and the gas phase within the NMR tube, as well as for dissolution effects.	Hydrogen	106-108	polyhomeotic homolog 2	Homo sapiens	110-114
8425541-6	1993	3",5"-pGp is bound to RNase T1 in the anti form, with guanine in the specific recognition site; the 3"-phosphate protrudes into the solvent, and the 5"-phosphate hydrogen bonds with Lys41 O and Asn43 N4.	Hydrogen	162-170	phosphoglycolate phosphatase	Homo sapiens	6-9
8416969-2	1993	The stereochemistry and kinetics for hydrogen transfer to the catalytically essential NAD+ of S-adenosylhomocysteine hydrolase (SAHase) have been determined for selected adenosine analogues.	Hydrogen	37-45	adenosylhomocysteinase	Homo sapiens	94-126
8416969-2	1993	The stereochemistry and kinetics for hydrogen transfer to the catalytically essential NAD+ of S-adenosylhomocysteine hydrolase (SAHase) have been determined for selected adenosine analogues.	Hydrogen	37-45	adenosylhomocysteinase	Homo sapiens	128-134
8416969-3	1993	Reduced SAHase (ENADH), which was made by reconstituting apoSAHase with NADH, stereospecifically transferred the pro-R hydrogen of NADH to 3"-ketoadenosine, a proposed reaction intermediate.	Hydrogen	119-127	adenosylhomocysteinase	Homo sapiens	8-14
1472498-5	1992	(iii) Investigation of specificity at P3" supports our earlier hypothesis that SLN has a requirement for a hydrogen-bond donor at this position in its substrates.	Hydrogen	107-115	sarcolipin	Homo sapiens	79-82
1335082-4	1992	The derivatives with a hydrogen or methyl group at C-1, fluorine at C-6, and piperazinyl or 4-methyl-1-piperazinyl group at C-7 showed superior in vitro antibacterial activity, and the derivatives with 4-methyl-1-piperazinyl group at C-7 had potent in vivo activity.	Hydrogen	23-31	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	51-54
1469708-9	1992	There is a remarkable correspondence between the structural modules of ACBP/DBI as determined by 1H nuclear magnetic resonance spectroscopy and the exon-intron architecture of the ACBP/DBI gene.	Hydrogen	97-99	diazepam binding inhibitor	Rattus norvegicus	71-75
1469708-9	1992	There is a remarkable correspondence between the structural modules of ACBP/DBI as determined by 1H nuclear magnetic resonance spectroscopy and the exon-intron architecture of the ACBP/DBI gene.	Hydrogen	97-99	diazepam binding inhibitor	Rattus norvegicus	76-79
1469708-9	1992	There is a remarkable correspondence between the structural modules of ACBP/DBI as determined by 1H nuclear magnetic resonance spectroscopy and the exon-intron architecture of the ACBP/DBI gene.	Hydrogen	97-99	diazepam binding inhibitor	Rattus norvegicus	180-184
1469708-9	1992	There is a remarkable correspondence between the structural modules of ACBP/DBI as determined by 1H nuclear magnetic resonance spectroscopy and the exon-intron architecture of the ACBP/DBI gene.	Hydrogen	97-99	diazepam binding inhibitor	Rattus norvegicus	185-188
1429633-2	1992	Electronic and coordination structures of the ferric heme iron in the recombinant myoglobin proteins were examined by optical absorption, EPR, 1H NMR, magnetic circular dichroism, and x-ray spectroscopy.	Hydrogen	143-145	myoglobin	Homo sapiens	82-91
1420142-0	1992	NMR studies of the conformational change in human N-p21ras produced by replacement of bound GDP with the GTP analog GTP gamma S. 1H-Detected 15N-edited NMR in solution was used to study the conformational differences between the GDP- and GTP gamma S-bound forms of human N-p21ras.	Hydrogen	129-131	HRas proto-oncogene, GTPase	Homo sapiens	52-58
1425680-0	1992	Solution conformation of human neuropeptide Y by 1H nuclear magnetic resonance and restrained molecular dynamics.	Hydrogen	49-51	neuropeptide Y	Homo sapiens	31-45
1358235-0	1992	The effect of H2-blockade on plasma gastrin concentration in patients with an achlorhydric stomach.	Hydrogen	14-16	gastrin	Homo sapiens	36-43
1390698-4	1992	Since virtually all abasic sites at the C are part of a bistranded lesions, hydrogen transfer from C-1" of C into the drug should reflect only the bistranded reaction.	Hydrogen	76-84	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	99-102
1390698-9	1992	1H NMR spectroscopic analysis of the reacted chromophore showed that 2H had been selectively transferred into the C-2 position to the extent of approximately 22%.	Hydrogen	0-2	complement C2	Homo sapiens	114-117
1390678-0	1992	1H NMR assignments and secondary structure of human beta 2-microglobulin in solution.	Hydrogen	0-2	beta-2-microglobulin	Homo sapiens	52-72
1386670-1	1992	The diradical form of thiol-activated neocarzinostatin chromophore resides in the minor groove of DNA, where it has access to hydrogen atoms at the C-5", C-1", and C-4" positions of deoxyribose on each strand.	Hydrogen	126-134	complement C5	Homo sapiens	148-151
1386670-1	1992	The diradical form of thiol-activated neocarzinostatin chromophore resides in the minor groove of DNA, where it has access to hydrogen atoms at the C-5", C-1", and C-4" positions of deoxyribose on each strand.	Hydrogen	126-134	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	154-157
1386670-1	1992	The diradical form of thiol-activated neocarzinostatin chromophore resides in the minor groove of DNA, where it has access to hydrogen atoms at the C-5", C-1", and C-4" positions of deoxyribose on each strand.	Hydrogen	126-134	complement C4A (Rodgers blood group)	Homo sapiens	164-167
1385725-0	1992	1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins.	Hydrogen	0-2	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	99-106
1385725-3	1992	We have obtained the 1H, 13C, and 15N NMR assignments for the RBD of the human hnRNP C proteins.	Hydrogen	21-23	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	79-86
1627549-3	1992	In the presence of human erythrocyte glyoxalase I, high-field 1H NMR analysis reveals that the R and S isomers (approximately 20 mM) are both converted to glutathiohydroxyacetone at rates of 0.8 and 0.4 s-1, respectively.	Hydrogen	62-64	glyoxalase I	Homo sapiens	37-49
1318834-2	1992	The CHn groups in the aliphatic side chains of horse cytochrome c have been characterized according to the chemical shifts of both 13C-NMR and 1H-NMR signals, their temperature dependence and the number of attached protons, n. The primary assignments of resonances from the 55 side-chain methyl and the 27 methine groups were obtained directly for the oxidised and the reduced forms.	Hydrogen	143-145	cytochrome c, somatic	Equus caballus	53-65
1325688-9	1992	Energetically, the decreased potency can be accounted for by the loss of two hydrogen bonds, one at the C-13 -OH of dcSTX, and the other at the amino group in the carbamoyl function of STX.	Hydrogen	77-85	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Rattus norvegicus	118-121
1325688-11	1992	Thus, the near-identical actions of STX and TTX can be attributed to the common sharing of one ion-pair site and four hydrogen-bonding sites.	Hydrogen	118-126	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Rattus norvegicus	36-39
1325688-12	1992	If glutamate 387 of rat brain sodium channel II were the anionic site which ion-pairs with the 7, 8, 9 guanidinium of STX, then the carbonyl oxygen of asparagin 388 is the hydrogen-acceptor for the C-12 gem-diols.	Hydrogen	172-180	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Rattus norvegicus	118-121
1311598-0	1992	1H NMR spectroscopic studies on the interactions between human plasma antithrombin III and defined low molecular weight heparin fragments.	Hydrogen	0-2	serpin family C member 1	Homo sapiens	70-86
1311598-4	1992	Perturbations to the 1H resonances in the NMR spectrum of antithrombin upon binding of the two series of heparin fragments are compared to those generated by intact heparin binding, as well as to the effects of binding of a synthetic high-affinity pentasaccharide.	Hydrogen	21-23	serpin family C member 1	Homo sapiens	58-70
1311598-6	1992	Three of the heparin fragments (hexasaccharide-2, octasaccharide-2, and octasaccharide-1) produce almost identical perturbations in the antithrombin 1H NMR spectrum compared to binding of intact heparin, including perturbations of resonances from tryptophan 49.	Hydrogen	149-151	serpin family C member 1	Homo sapiens	136-148
1731871-0	1992	Sequence-specific 1H and 15N resonance assignments for human dihydrofolate reductase in solution.	Hydrogen	18-20	dihydrofolate reductase	Homo sapiens	61-84
1743298-1	1991	The backbone 1H, 13C and 15N chemical shifts of cyclophilin (CyP) when bound to cyclosporin A (CsA) have been assigned from heteronuclear two- and three-dimensional NMR experiments involving selectively 15N- and uniformly 15N- and 15N,13C-labeled cyclophilin.	Hydrogen	13-15	peptidylprolyl isomerase G	Homo sapiens	48-59
1743298-1	1991	The backbone 1H, 13C and 15N chemical shifts of cyclophilin (CyP) when bound to cyclosporin A (CsA) have been assigned from heteronuclear two- and three-dimensional NMR experiments involving selectively 15N- and uniformly 15N- and 15N,13C-labeled cyclophilin.	Hydrogen	13-15	peptidylprolyl isomerase G	Homo sapiens	61-64
1743298-2	1991	From an analysis of the 1H and 15N chemical shifts of CyP that change upon binding to CsA and from CyP/CsA NOEs, we have determined the regions of cyclophilin involved in binding to CsA.	Hydrogen	24-26	peptidylprolyl isomerase G	Homo sapiens	147-158
1932015-5	1991	The data show that the guanine amino group of the nucleotide interacts differently with both EF-Tu and p21 than it does with water, showing a change in hydrogen-bonding properties upon binding.	Hydrogen	152-160	H3 histone pseudogene 16	Homo sapiens	103-106
28235481-8	2017	Collectively, these data indicated that a hydrogen bond between Y109 residue and AzA is a major determinant of the Olfr544-AzA interaction and activation.	Hydrogen	42-50	olfactory receptor family 55 subfamily B member 4	Mus musculus	115-122
28091961-3	2017	Here we report the 1H, 13C and 15N backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2.	Hydrogen	19-21	ubiquitin specific peptidase 20	Homo sapiens	106-111
28091961-3	2017	Here we report the 1H, 13C and 15N backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2.	Hydrogen	19-21	ubiquitin specific peptidase 20	Homo sapiens	112-116
28804613-9	2017	Results of docking showed that the ligands interacted mainly with residues II-S6 of NaV1.2 by making hydrogen bonds and have additional hydrophobic interactions with other domains in the channel"s inner pore.	Hydrogen	101-109	sodium voltage-gated channel alpha subunit 2	Homo sapiens	84-90
28293795-9	2017	Based on their published crystallographic structures bound to their human receptor IL10R1, we report a structure-based design of hIL-10 and ebvIL-10 inhibitors based on 3 loops from IL10R1 that establish specific hydrogen bonds with the two IL10s.	Hydrogen	213-221	interleukin 10 receptor subunit alpha	Homo sapiens	83-89
28293795-9	2017	Based on their published crystallographic structures bound to their human receptor IL10R1, we report a structure-based design of hIL-10 and ebvIL-10 inhibitors based on 3 loops from IL10R1 that establish specific hydrogen bonds with the two IL10s.	Hydrogen	213-221	interleukin 10	Homo sapiens	129-135
28293795-9	2017	Based on their published crystallographic structures bound to their human receptor IL10R1, we report a structure-based design of hIL-10 and ebvIL-10 inhibitors based on 3 loops from IL10R1 that establish specific hydrogen bonds with the two IL10s.	Hydrogen	213-221	interleukin 10 receptor subunit alpha	Homo sapiens	182-188
1724685-5	1991	Although the N-terminal hexapeptide is important for high affinity binding to the NK1 receptor the present study provides evidence for that this effects is not caused by the side chains of the amino acids in position 1-6 or as results of intramolecular hydrogen bonding with the C-terminal part of the peptide.	Hydrogen	253-261	tachykinin receptor 1	Rattus norvegicus	82-94
20701398-1	2010	Secondary hydrogen isotope effects on the geometries, electronic wave functions and binding energies of cation-pi complexes (cation = Li(+), Na(+), K(+) and pi = acetylene, ethylene, benzene) are investigated with NEO/HF and NEO/MP2 methods.	Hydrogen	10-18	tryptase pseudogene 1	Homo sapiens	229-232
28166210-5	2017	The polar spine residue and water network of AurA are essential for phosphorylation-driven activation, but an alternative form of the water network found in related kinases can support Tpx2-driven activation, suggesting that variations in the water-mediated hydrogen bond network mediate regulatory diversification in protein kinases.	Hydrogen	258-266	TPX2 microtubule nucleation factor	Homo sapiens	185-189
28298111-5	2017	An additional mechanism found operational in the 1H-2H CP case that was absent in the spin-1/2 counterpart, concerns the onset of a pseudo-static zero-quantum CP mode, driven by a quadrupole-modulated rf/dipolar recoupling term arising under the action of MAS.	Hydrogen	49-51	spindlin 1	Homo sapiens	86-94
20502928-8	2010	These findings are consistent with the presence of a hydrogen-bonding network at the heme"s distal side within the active site of HO-2 with potentially significant differences from that observed in HO-1.	Hydrogen	53-61	heme oxygenase 1	Homo sapiens	198-202
29071009-0	2017	Hydrogen Electrooxidation in Ionic Liquids Catalyzed by the NTf2 Radical.	Hydrogen	0-8	nuclear transport factor 2	Homo sapiens	60-64
29071009-1	2017	Hydrogen electrooxidation via a "hydrogen abstraction" mechanism in an aprotic ionic liquid 1-butyl-1-methylpyrrolidinium bis-(trifluoromethylsulfonyl) [Bmpy][NTf2] under anaerobic conditions was investigated using cyclic voltammetry and density functional theory (DFT).	Hydrogen	0-8	nuclear transport factor 2	Homo sapiens	159-163
1909576-0	1991	Structure-function relationships in human epidermal growth factor studied by site-directed mutagenesis and 1H NMR.	Hydrogen	107-109	epidermal growth factor	Homo sapiens	42-65
1931558-1	1991	1H NMR was used to analyze human cerebrospinal fluid (CSF) from a group of neurological disease controls and from a vitamin B12 deficient patient.	Hydrogen	0-2	colony stimulating factor 2	Homo sapiens	33-58
20683790-1	2010	The mechanism of transformation of two radicals (R1p and R1i) obtained by addition of a hydrogen atom to an external and internal carbon atom of dicyclopenta[de,mn]anthracene (P1) was investigated.	Hydrogen	88-96	CD1b molecule	Homo sapiens	49-52
2019363-8	1991	This suggests that access of hydrogen ion to the pH-sensitive sites governing gastrin release by mucosal ammonia produced by H. pylori urease is not a critical factor.	Hydrogen	29-37	gastrin	Homo sapiens	78-85
29071009-1	2017	Hydrogen electrooxidation via a "hydrogen abstraction" mechanism in an aprotic ionic liquid 1-butyl-1-methylpyrrolidinium bis-(trifluoromethylsulfonyl) [Bmpy][NTf2] under anaerobic conditions was investigated using cyclic voltammetry and density functional theory (DFT).	Hydrogen	33-41	nuclear transport factor 2	Homo sapiens	159-163
29071009-2	2017	It is found that a platinum bound NTf2 radical (NTf2 ) formed by the oxidation of NTf2- at anodic potential can catalyze the oxidation of hydrogen and enhance its reaction rate.	Hydrogen	138-146	nuclear transport factor 2	Homo sapiens	34-38
29071009-2	2017	It is found that a platinum bound NTf2 radical (NTf2 ) formed by the oxidation of NTf2- at anodic potential can catalyze the oxidation of hydrogen and enhance its reaction rate.	Hydrogen	138-146	nuclear transport factor 2	Homo sapiens	48-52
29071009-2	2017	It is found that a platinum bound NTf2 radical (NTf2 ) formed by the oxidation of NTf2- at anodic potential can catalyze the oxidation of hydrogen and enhance its reaction rate.	Hydrogen	138-146	nuclear transport factor 2	Homo sapiens	48-52
29071009-3	2017	Both experimental and theoretical studies (DFT) have supported a mechanism involving a NTf2  radical intermediate that catalyzes the hydrogen redox processes.	Hydrogen	133-141	nuclear transport factor 2	Homo sapiens	87-91
20625986-1	2010	The formation of hydrogen bonds and molecular dynamics for the molecules cis-1-(2-hydroxy-5-methylphenyl)ethanone oxime (I) and N-(2-hydroxy-4-methylphenyl)acetamide (II) have been investigated in solution using NMR.	Hydrogen	17-25	suppressor of cytokine signaling 1	Homo sapiens	73-78
28189393-8	2017	This selectivity was also supported by computational docking models that suggest DY181 forms more extensive hydrogen bound network with ERRbeta which should result in higher binding affinity on ERRbeta over ERRgamma.	Hydrogen	108-116	estrogen related receptor beta	Homo sapiens	136-143
28189393-8	2017	This selectivity was also supported by computational docking models that suggest DY181 forms more extensive hydrogen bound network with ERRbeta which should result in higher binding affinity on ERRbeta over ERRgamma.	Hydrogen	108-116	estrogen related receptor beta	Homo sapiens	194-201
28098910-7	2017	In conclusion, H2-rich saline may significantly improve NAFLD, possibly by reducing oxidative stress and activating hepatic PPARalpha and PPARgamma expression.	Hydrogen	15-17	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	138-147
28290719-2	2017	The pharmacophore model for ALK (r2 = 0.96, q2 = 0.692) suggested that two hydrogen bond acceptors and three hydrophobic groups arranged in 3-D space are essential for the binding affinity of ALK inhibitors.	Hydrogen	75-83	ALK receptor tyrosine kinase	Homo sapiens	28-31
1676713-4	1991	Courses of standard therapy with both H2-antagonists and H+/K+ inhibitors cause a significant rise in 24 h integrated plasma gastrin levels that is inversely correlated to the 24-h integrated gastric acidity.	Hydrogen	38-40	gastrin	Homo sapiens	125-132
1676713-5	1991	The rise in fasting or integrated plasma gastrin levels observed in patients treated with H2-antagonists is small and of unclear clinical significance.	Hydrogen	90-92	gastrin	Homo sapiens	41-48
1851480-6	1991	In addition, studies of the effect of pH on the 1H-NMR spectrum of yeast iso-1 ferricytochrome c show that the heme 3-CH3 proton resonance exhibits a pH-dependent shift with an apparent pK in the range of 6.0-7.0.	Hydrogen	48-50	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	73-78
28290719-2	2017	The pharmacophore model for ALK (r2 = 0.96, q2 = 0.692) suggested that two hydrogen bond acceptors and three hydrophobic groups arranged in 3-D space are essential for the binding affinity of ALK inhibitors.	Hydrogen	75-83	ALK receptor tyrosine kinase	Homo sapiens	192-195
20236836-0	2010	Oxazolone versus macrocycle structures for Leu-enkephalin b2-b4: insights from infrared multiple-photon dissociation spectroscopy and gas-phase hydrogen/deuterium exchange.	Hydrogen	144-152	prodynorphin	Homo sapiens	43-57
28627348-1	2017	OBJECTIVE: To observe the effect of hydrogen-rich water on the CD34 expression and angiogenesis in lesion boundary brain tissue of rats with traumatic brain injury (TBI).	Hydrogen	36-44	CD34 molecule	Rattus norvegicus	63-67
28627348-19	2017	CONCLUSIONS: Hydrogen-rich water promote CD34+ cells home to the site of injured tissue in rats with TBI, is involved in angiogenesis, and improve clinical outcomes during brain functional recovery.	Hydrogen	13-21	CD34 molecule	Rattus norvegicus	41-45
1901020-4	1991	It has been shown that selective deuterium labeling of the Fv fragment, which is half the size of the Fab fragment, provides 1H NMR spectral data at a sufficient resolution for a detailed structural analysis of the antigen-combining site.	Hydrogen	125-127	FA complementation group B	Homo sapiens	102-105
1998678-1	1991	Two-dimensional 1H NMR methods and a knowledge of the X-ray crystal structure have been used to make resonance assignments for the amino acid side chains of dihydrofolate reductase from Escherichia coli complexed with methotrexate.	Hydrogen	16-18	Dihydrofolate reductase	Escherichia coli	157-180
28170215-3	2017	The existence of multiple hydrogen bond pairs as well as tertiary amines makes the S5-TMPETA polymers manifest temperature- and pH-dependent phase transition.	Hydrogen	26-34	ribosomal protein S5	Homo sapiens	83-92
20407683-9	2010	The computed results at the DFT/MP2 level also indicated that the IR intensity of the H-bond donor CH-stretch increases by two to three orders of magnitude for the CHCl(3) complex whereas for the fluoroform complex the same decreases by an order of magnitude, which are consistent with the trend reported in the case of C-HO type of blue shifting hydrogen bonds.	Hydrogen	347-355	tryptase pseudogene 1	Homo sapiens	32-35
28088866-10	2017	In addition, at higher temperatures, another mechanism can contribute, in which hydrogen atoms abstract hydrogen from C12H26 producing various n-dodecyl radicals and these radicals then decompose by C-C bond beta-scission to C3 to C11 alkenes.	Hydrogen	80-88	aldo-keto reductase family 1 member C4	Homo sapiens	231-234
28088866-10	2017	In addition, at higher temperatures, another mechanism can contribute, in which hydrogen atoms abstract hydrogen from C12H26 producing various n-dodecyl radicals and these radicals then decompose by C-C bond beta-scission to C3 to C11 alkenes.	Hydrogen	104-112	aldo-keto reductase family 1 member C4	Homo sapiens	231-234
20411194-3	2010	Using QM MP2/aug-cc-pVDZ the calculated average interaction energy reveals that the hydrogen-bonded acetone-water complex is energetically more stable under supercritical conditions than ambient conditions and its stability is little affected by variations of temperature and/or pressure.	Hydrogen	84-92	tryptase pseudogene 1	Homo sapiens	9-12
28198446-9	2017	Thr233, a unique residue found in ZIKV but not in other flaviviruses, organizes a central hydrogen bonding network at NS1 dimer interface.	Hydrogen	90-98	influenza virus NS1A binding protein	Homo sapiens	118-121
1815967-7	1991	Breath hydrogen concentration increased gradually, indicating slight but significant carbohydrate malabsorption after the highest dose of the alpha-glucosidase inhibitor.	Hydrogen	7-15	sucrase-isomaltase	Homo sapiens	142-159
20435084-3	2010	It was found that the protein level of PKC and PKC-betaII (but not PKC-alpha) in cerebral cortex microvessels increased significantly at 0.5h and 1h after EMP exposure compared with sham-exposed animals and then recovered at 3h.	Hydrogen	146-148	phospholipase C, beta 2	Rattus norvegicus	47-57
1784628-3	1991	This effect was dose-dependent and confined to the first carbohydrate load in the morning, thus indicating the duration of alpha-glucosidase inhibition of less than 4 h. Sucrose malabsorption, indicated by breath hydrogen responses, occurred dose-dependently with 50 and 100 mg, but not with 25 mg of miglitol.	Hydrogen	213-221	sucrase-isomaltase	Homo sapiens	123-140
28186585-14	2017	Modeling for the mutant proteins revealed that the simple aromatic ring of Trp147 in p.Arg147Trp destroyed the two hydrogen bonds between Arg147-Lys146 and Arg147-Lys151, and steric hindranted with Arg178.	Hydrogen	115-123	DEAH-box helicase 40	Homo sapiens	87-93
28186585-14	2017	Modeling for the mutant proteins revealed that the simple aromatic ring of Trp147 in p.Arg147Trp destroyed the two hydrogen bonds between Arg147-Lys146 and Arg147-Lys151, and steric hindranted with Arg178.	Hydrogen	115-123	DEAH-box helicase 40	Homo sapiens	138-144
20459102-3	2010	Subsequent studies of these NPs" catalytic properties for preferential CO oxidation in hydrogen-rich environments (PROX), combined with Density Functional Theory (DFT)-based mechanistic studies, elucidate important trends and provide fundamental understanding of the reactivity of Pt shells as a function of the core metal.	Hydrogen	87-95	pyruvate dehydrogenase complex component X	Homo sapiens	115-119
28134364-6	2017	Further investigation of the IR-dip spectra has revealed a hydrogen-bonded NH stretching mode, supporting the presence of the syn-AAP(NH)-(H2O)1 conformer.	Hydrogen	59-67	synemin	Homo sapiens	126-129
2269352-7	1990	This positioning facilitates the compensatory hydrogen bonding between solvent and residues P-3 and P-4 (relative to proline, P), through the formation of the kink.	Hydrogen	46-54	solute carrier family 10 member 4	Homo sapiens	100-103
20459102-5	2010	Among the systems studied, Ru@Pt core-shell NPs exhibit the highest PROX activity, where the CO oxidation is complete by 30 degrees C (1000 ppm CO in H(2)).	Hydrogen	150-155	pyruvate dehydrogenase complex component X	Homo sapiens	68-72
28155884-6	2017	Further computational modeling analysis shows that talin2 S339 formed a hydrogen bond with E353, which is critical for inducing key hydrogen bonds between talin2 N326 and beta1-integrin R760, and between talin2 K327 and beta1-integrin D759.	Hydrogen	72-80	integrin subunit beta 1	Homo sapiens	171-185
28155884-6	2017	Further computational modeling analysis shows that talin2 S339 formed a hydrogen bond with E353, which is critical for inducing key hydrogen bonds between talin2 N326 and beta1-integrin R760, and between talin2 K327 and beta1-integrin D759.	Hydrogen	72-80	integrin subunit beta 1	Homo sapiens	220-234
20484015-3	2010	Structural analyses of the oxidized form of hRRM2 and hp53R2 indicate that both proteins contain a conserved Gln127-hp53R2/Gln165-hRRM2 close to the dinuclear iron center and the essential tyrosine residue Tyr124-hp53R2/Tyr162-hRRM2 forms hydrogen bonds with the tyrosine and iron ligands, implying a critical role for the glutamine residue in assembling the dityrosyl-diiron radical cofactor.	Hydrogen	239-247	ribonucleotide reductase regulatory subunit M2	Homo sapiens	44-49
28155884-6	2017	Further computational modeling analysis shows that talin2 S339 formed a hydrogen bond with E353, which is critical for inducing key hydrogen bonds between talin2 N326 and beta1-integrin R760, and between talin2 K327 and beta1-integrin D759.	Hydrogen	132-140	integrin subunit beta 1	Homo sapiens	171-185
28155884-6	2017	Further computational modeling analysis shows that talin2 S339 formed a hydrogen bond with E353, which is critical for inducing key hydrogen bonds between talin2 N326 and beta1-integrin R760, and between talin2 K327 and beta1-integrin D759.	Hydrogen	132-140	integrin subunit beta 1	Homo sapiens	220-234
28155884-8	2017	These hydrogen bonds were not observed in talin1/beta1-integrin, but did exist in talin1C336S/beta1-integrin complex.	Hydrogen	6-14	integrin subunit beta 1	Homo sapiens	49-63
28155884-8	2017	These hydrogen bonds were not observed in talin1/beta1-integrin, but did exist in talin1C336S/beta1-integrin complex.	Hydrogen	6-14	integrin subunit beta 1	Homo sapiens	94-108
28155884-9	2017	These results suggest that talin2 S339 forms a hydrogen bond with E353 to mediate its high affinity to beta1-integrin.	Hydrogen	47-55	integrin subunit beta 1	Homo sapiens	103-117
2241171-6	1990	In addition, the data of FAB-MS and 1H NMR suggested that the unknown residues (modified histidine) within AGT-1 and AGT-2 should have the 2-imidazolone structure.	Hydrogen	36-38	solute carrier family 7 member 13	Homo sapiens	107-112
20484015-3	2010	Structural analyses of the oxidized form of hRRM2 and hp53R2 indicate that both proteins contain a conserved Gln127-hp53R2/Gln165-hRRM2 close to the dinuclear iron center and the essential tyrosine residue Tyr124-hp53R2/Tyr162-hRRM2 forms hydrogen bonds with the tyrosine and iron ligands, implying a critical role for the glutamine residue in assembling the dityrosyl-diiron radical cofactor.	Hydrogen	239-247	ribonucleotide reductase regulatory subunit M2	Homo sapiens	130-135
2231727-11	1990	The third Ca2+ is also seven-co-ordinated, to five oxygen atoms belonging to three different oncomodulin molecules and to two water molecules which form hydrogen bonds to a fourth oncomodulin; thus, this intermolecular Ca2+ and its equivalents interlink the molecules into zigzag layers normal to the b axis with a spacing of b/2 or 32.14 A.	Hydrogen	153-161	oncomodulin	Rattus norvegicus	180-191
27993957-8	2017	Taken together, our data suggest that fructose via uric acid stimulates renal expression of PRR/soluble PRR that stimulate sodium/hydrogen exchanger 3 and Na/K/2Cl cotransporter expression and intrarenal renin-angiotensin system to induce salt-sensitive hypertension.	Hydrogen	130-138	ATPase H+ transporting accessory protein 2	Homo sapiens	92-95
20484015-3	2010	Structural analyses of the oxidized form of hRRM2 and hp53R2 indicate that both proteins contain a conserved Gln127-hp53R2/Gln165-hRRM2 close to the dinuclear iron center and the essential tyrosine residue Tyr124-hp53R2/Tyr162-hRRM2 forms hydrogen bonds with the tyrosine and iron ligands, implying a critical role for the glutamine residue in assembling the dityrosyl-diiron radical cofactor.	Hydrogen	239-247	ribonucleotide reductase regulatory subunit M2	Homo sapiens	130-135
27993957-8	2017	Taken together, our data suggest that fructose via uric acid stimulates renal expression of PRR/soluble PRR that stimulate sodium/hydrogen exchanger 3 and Na/K/2Cl cotransporter expression and intrarenal renin-angiotensin system to induce salt-sensitive hypertension.	Hydrogen	130-138	ATPase H+ transporting accessory protein 2	Homo sapiens	104-107
20484015-4	2010	The present work also showed that Tyr221 in hRRM2, which is replaced by Phe183 in hp53R2, forms a hydrogen bond with Tyr162 to extend the hydrogen bond network from Gln165-hRRM2.	Hydrogen	98-106	ribonucleotide reductase regulatory subunit M2	Homo sapiens	44-49
20484015-4	2010	The present work also showed that Tyr221 in hRRM2, which is replaced by Phe183 in hp53R2, forms a hydrogen bond with Tyr162 to extend the hydrogen bond network from Gln165-hRRM2.	Hydrogen	98-106	ribonucleotide reductase regulatory subunit M2	Homo sapiens	172-177
20484015-4	2010	The present work also showed that Tyr221 in hRRM2, which is replaced by Phe183 in hp53R2, forms a hydrogen bond with Tyr162 to extend the hydrogen bond network from Gln165-hRRM2.	Hydrogen	138-146	ribonucleotide reductase regulatory subunit M2	Homo sapiens	44-49
28059504-5	2017	A SrTiO3:La,Rh/C/BiVO4:Mo sheet is shown to achieve unassisted pure-water (pH 6.8) splitting with a solar-to-hydrogen energy conversion efficiency (STH) of 1.2% at 331 K and 10 kPa, while retaining 80% of this efficiency at 91 kPa.	Hydrogen	109-117	saitohin	Homo sapiens	148-151
28012298-3	2017	This amounts to converting the spin-state selectivity from 1H spin states to 13C spin states in the spectra of long-range coupled 1H spins, allowing convenient measurement of heteronuclear coupling constants similar to other S3 or E.COSY-type methods.	Hydrogen	130-132	spindlin 1	Homo sapiens	31-35
2211722-2	1990	1H nuclear magnetic resonance spectroscopy showed that Fab fragments stabilize an ordered structure in the tetranucleotide d(CG)2.	Hydrogen	0-2	FA complementation group B	Homo sapiens	55-58
2271620-11	1990	Two distinct binary RBG200 DHFR-NADP+ complexes were detected by monitoring the 1H NMR chemical shifts and line widths of the coenzyme in the presence of RBG200 DHFR.	Hydrogen	80-82	dihydrofolate reductase	Homo sapiens	27-31
2271620-11	1990	Two distinct binary RBG200 DHFR-NADP+ complexes were detected by monitoring the 1H NMR chemical shifts and line widths of the coenzyme in the presence of RBG200 DHFR.	Hydrogen	80-82	dihydrofolate reductase	Homo sapiens	161-165
28012298-3	2017	This amounts to converting the spin-state selectivity from 1H spin states to 13C spin states in the spectra of long-range coupled 1H spins, allowing convenient measurement of heteronuclear coupling constants similar to other S3 or E.COSY-type methods.	Hydrogen	130-132	spindlin 1	Homo sapiens	62-66
28012298-3	2017	This amounts to converting the spin-state selectivity from 1H spin states to 13C spin states in the spectra of long-range coupled 1H spins, allowing convenient measurement of heteronuclear coupling constants similar to other S3 or E.COSY-type methods.	Hydrogen	130-132	spindlin 1	Homo sapiens	62-66
20484015-4	2010	The present work also showed that Tyr221 in hRRM2, which is replaced by Phe183 in hp53R2, forms a hydrogen bond with Tyr162 to extend the hydrogen bond network from Gln165-hRRM2.	Hydrogen	138-146	ribonucleotide reductase regulatory subunit M2	Homo sapiens	172-177
28098177-2	2017	X-ray diffraction structures of oxidoreductase flavoenzymes have revealed recurrent features which facilitate catalysis, such as a hydrogen bond between a main chain nitrogen atom and the flavin redox center (N5).	Hydrogen	131-139	thioredoxin reductase 1	Homo sapiens	32-46
2268224-2	1990	The accumulation of metabolic by-products, namely hydrogen ions and diprotonated phosphate, interferes with actin-myosin interaction, effectively preserving muscle ATP levels by preventing further ATP hydrolysis.	Hydrogen	50-58	myosin heavy chain 14	Homo sapiens	114-120
20484015-6	2010	This study correlates the distinct catalytic mechanisms of the small subunits hp53R2 and hRRM2 with a hydrogen-bonding network and provides novel directions for designing and developing subunit-specific therapeutic agents for human RNR enzymes.	Hydrogen	102-110	ribonucleotide reductase regulatory subunit M2	Homo sapiens	89-94
20623858-4	2010	The results showed that MC-RR degradation by attacking of ozone and hydrogen radicals mainly involved in substitution and cleavage of the Adda conjugated diene structure, cleavage of the peptide bond between Mdha and Ala. And Adda degradation pathway exerted a dominant position during the process.	Hydrogen	68-76	malate dehydrogenase 1	Homo sapiens	208-212
2384540-1	1990	A new method to measure regional CBF is presented, applying both dynamic and integral analyses to a dynamic sequence of positron emission tomographic scans collected during and following the administration of H2(15)O (inhalation of C15O2).	Hydrogen	209-211	CCAAT enhancer binding protein zeta	Homo sapiens	33-36
28054048-4	2017	Reflection-absorption infrared spectroscopy (RAIRS) measurements further indicated that the STM observed intermolecular linkages are stabilized via hydrogen bonding.	Hydrogen	148-156	sulfotransferase family 1A member 3	Homo sapiens	92-95
27966954-1	2017	The discovery of a novel potent type II ABL/c-KIT dual kinase inhibitor compound 34 (CHMFL-ABL/KIT-155), which utilized a hydrogen bond formed by NH on the kinase backbone and carbonyl oxygen of 34 as a unique hinge binding, is described.	Hydrogen	122-130	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	40-43
1697101-0	1990	An antibody binding site on cytochrome c defined by hydrogen exchange and two-dimensional NMR.	Hydrogen	52-60	cytochrome c, somatic	Equus caballus	28-40
20376003-8	2010	The ability of FTO to distinguish 3-meT or 3-meU from other nucleotides is conferred by its hydrogen-bonding interaction with the two carbonyl oxygen atoms in 3-meT or 3-meU.	Hydrogen	92-100	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	15-18
1697101-1	1990	The interaction of a protein antigen, horse cytochrome c (cyt c), with a monoclonal antibody has been studied by hydrogen-deuterium (H-D) exchange labeling and two-dimensional nuclear magnetic resonance (2D NMR) methods.	Hydrogen	113-121	cytochrome c, somatic	Equus caballus	44-56
1697101-1	1990	The interaction of a protein antigen, horse cytochrome c (cyt c), with a monoclonal antibody has been studied by hydrogen-deuterium (H-D) exchange labeling and two-dimensional nuclear magnetic resonance (2D NMR) methods.	Hydrogen	113-121	cytochrome c, somatic	Equus caballus	58-63
27959494-5	2017	The molecular dynamics simulations of the apo enzyme and cysteine-phosphoryl intermediate states with and without bound CGA suggest CGA binding inhibits PTP1B by altering hydrogen bonding patterns at the active site.	Hydrogen	171-179	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	153-158
28063424-5	2017	Conversely, the experimental elastic constant of C11 of ice VII gradually changes from an ice VIII like asymmetric hydrogen bond to a symmetric bond character within a wide pressure range.	Hydrogen	115-123	RNA polymerase III subunit K	Homo sapiens	49-52
2167380-1	1990	In human metallothionein-2, the exchange rate constants of ten amide protons were found to range from 1.7 x 10(-4) to 1 x 10(-1) min-1 at pH 6.3 and 8 degrees C. Most of these slowly exchanging protons could be associated with hydrogen bonds in secondary structure elements of the alpha-domain.	Hydrogen	227-235	metallothionein 2A	Homo sapiens	9-26
20307070-0	2010	Regulation of phenylalanine hydroxylase: conformational changes upon phenylalanine binding detected by hydrogen/deuterium exchange and mass spectrometry.	Hydrogen	103-111	phenylalanine hydroxylase	Rattus norvegicus	14-39
28045381-16	2017	A number of hydrogen-bond interactions that were previously observed in the structure of yeast ALAD with a cyclic intermediate resembling the product PBG appear to be weaker in the new structure, suggesting that these interactions are only optimal in the transition state.	Hydrogen	12-20	aminolevulinate dehydratase	Homo sapiens	95-99
20307070-2	2010	Hydrogen/deuterium exchange monitored by mass spectrometry has been used to gain insight into local conformational changes accompanying activation of rat phenylalanine hydroxylase by phenylalanine.	Hydrogen	0-8	phenylalanine hydroxylase	Rattus norvegicus	154-179
28013347-9	2017	Finally, we demonstrated the direct interaction between Ang II and MD2 protein via hydrogen bonds on Arg-90, Glu-92, and Asp-100.	Hydrogen	83-91	lymphocyte antigen 96	Rattus norvegicus	67-70
21389543-4	2010	In the complex, PU.1 causes a variation in the magnitude among DNA bases by means of directly recognizing the DNA bases through hydrogen bonds and inducing structural changes of the DNA structure from the canonical one.	Hydrogen	128-136	Spi-1 proto-oncogene	Homo sapiens	16-20
28458345-0	2017	Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-beta Induced Sirt1.	Hydrogen	0-8	sirtuin 1	Homo sapiens	111-116
28401156-7	2017	Molecular docking simulation demonstrated that the epitope could bind to the binding groove of MHC II and MHC I molecules by several hydrogen bonds.	Hydrogen	133-141	major histocompatibility complex, class I, C	Homo sapiens	95-98
28401156-7	2017	Molecular docking simulation demonstrated that the epitope could bind to the binding groove of MHC II and MHC I molecules by several hydrogen bonds.	Hydrogen	133-141	major histocompatibility complex, class I, C	Homo sapiens	106-109
2213591-15	1990	This observation suggests that in cultured Purkinje cells the sodium-hydrogen exchanger could be activated through a protein kinase C pathway only when pHi is maintained at a low physiological value by the activity of the chloride-bicarbonate exchange.	Hydrogen	69-77	glucose-6-phosphate isomerase	Rattus norvegicus	152-155
2372534-0	1990	Sequence-specific 1H NMR assignment and secondary structure of neuropeptide Y in aqueous solution.	Hydrogen	18-20	neuropeptide Y	Homo sapiens	63-77
2372534-1	1990	Sequence-specific assignment of the 1H NMR spectrum of the 36 amino acid polypeptide porcine neuropeptide Y (pNPY) at pH 3.1 is reported.	Hydrogen	36-38	neuropeptide Y	Homo sapiens	93-107
1692019-3	1990	The 1H NMR spectrum of PZP shows relatively few sharp resonances, which, by analogy with human alpha 2-macroglobulin, probably arise from the proteolytically sensitive bait region.	Hydrogen	4-6	alpha-2-macroglobulin	Homo sapiens	95-116
20108067-0	2010	1H, 13C and 15N backbone and side chain resonance assignments of human interleukin 1alpha.	Hydrogen	0-2	interleukin 1 alpha	Homo sapiens	71-89
2158989-4	1990	The 1H NMR spectrum of MPO-CN is found to have a remarkable similarity in the number, resonance pattern, and metal ion-induced relaxation properties of the resolved, hyperfine-shifted resonances to those reported earlier for the analogous complex of bovine lactoperoxidase (LPO-CN); moreover, the interproton connectivities between pairs of hyperfine-shifted proton sets, as reflected by the NOEs, are also essentially the same (Thanabal, V., and La Mar, G. N. (1989) Biochemistry 28, 7038-7044).	Hydrogen	4-6	myeloperoxidase	Bos taurus	23-26
2158989-4	1990	The 1H NMR spectrum of MPO-CN is found to have a remarkable similarity in the number, resonance pattern, and metal ion-induced relaxation properties of the resolved, hyperfine-shifted resonances to those reported earlier for the analogous complex of bovine lactoperoxidase (LPO-CN); moreover, the interproton connectivities between pairs of hyperfine-shifted proton sets, as reflected by the NOEs, are also essentially the same (Thanabal, V., and La Mar, G. N. (1989) Biochemistry 28, 7038-7044).	Hydrogen	4-6	lactoperoxidase	Bos taurus	274-277
2158989-7	1990	247, 147-150), we interpret the resultant similarity in 1H NMR spectral parameters for LPO-CN and MPO-CN as indicating that the prosthetic groups in MPO and LPO are very similar, and hence likely both porphyrins with a similarly functionalized periphery that allows covalent linkage to the protein matrix.	Hydrogen	56-58	lactoperoxidase	Bos taurus	87-90
29201052-1	2017	Previous in vitro studies demonstrated that aldosterone rapidly activates sodium-hydrogen exchangers 1 and 3 (NHE 1 and 3).	Hydrogen	81-89	solute carrier family 9 member A1	Rattus norvegicus	110-121
28174350-3	2017	Glutathione peroxidase 1 is a major antioxidant enzyme, preventing oxidative damage to renal cells by detoxifying hydrogen and lipid peroxides, which may involve in its pathogenesis.	Hydrogen	114-122	glutathione peroxidase 1	Homo sapiens	0-24
20122865-3	2010	The degradation rate of levofloxacin was accelerated with increased concentrations of CCl(4) via the accumulation of reactive chlorine species and the hindrance of ()OH radical combination reactions with atomic hydrogen.	Hydrogen	211-219	C-C motif chemokine ligand 4	Homo sapiens	86-92
29230324-1	2017	Early X-ray fiber diffraction studies have established that the spontaneous gel formation of guanosine 5"-monophosphate (5"-GMP) under slightly acidic conditions (e.g., pH 5) results from self-assembly of 5"-GMP into a helical structure in which hydrogen-bonded guanine bases form a continuous helix with 15 nucleotides per 4 turns.	Hydrogen	246-254	5'-nucleotidase, cytosolic II	Homo sapiens	124-127
29230324-1	2017	Early X-ray fiber diffraction studies have established that the spontaneous gel formation of guanosine 5"-monophosphate (5"-GMP) under slightly acidic conditions (e.g., pH 5) results from self-assembly of 5"-GMP into a helical structure in which hydrogen-bonded guanine bases form a continuous helix with 15 nucleotides per 4 turns.	Hydrogen	246-254	5'-nucleotidase, cytosolic II	Homo sapiens	208-211
2163125-4	1990	Diastereoisomers of 17-tetrahydropyranyl ether derivatives were recognized from characteristic modifications of 1H NMR signals of H-2", H-6", H-1, H-17, and 18-CH3 protons as well as from the 13C NMR doublet signals corresponding to C-2", C-4", C-6", C-12, C-13, C-16, and C-17 carbon atoms.	Hydrogen	112-114	cytokine like 1	Homo sapiens	273-277
20078087-7	2010	For the E-selectin/SLe(x) complex, the major molecular interactions are hydrogen bonds between Fuc and the Ca(2+) binding site in the carbohydrate-recognition domain, and Gal is important in determining the ligand specificity.	Hydrogen	72-80	selectin E	Homo sapiens	8-18
2185035-4	1990	The 1H NMR saturation transfer technique has been used to measure the rate of interconversion between the cis and trans forms of calbindin in the presence of PPIase (PPIase:calbindin concentration ratio 1:10) at 35 degrees C. No rate enhancement could be detected.	Hydrogen	4-6	calbindin 1	Homo sapiens	129-138
2191717-0	1990	NMR study of the phosphoryl binding loop in purine nucleotide proteins: evidence for strong hydrogen bonding in human N-ras p21.	Hydrogen	92-100	H3 histone pseudogene 16	Homo sapiens	124-127
2184125-4	1990	The drug-induced rise of plasma gastrin concentration is of no direct clinical concern, although it may be partly responsible for the phenomenon of tolerance to H2-blockade.	Hydrogen	161-163	gastrin	Homo sapiens	32-39
20118243-8	2010	Hydrogen-deuterium exchange mass spectrometry mapped distinct sites of GBP that interact with LPS and with CRP, consistent with in silico predictions.	Hydrogen	0-8	galectin 1	Homo sapiens	71-74
20176484-4	2010	CoMFA maps agree with docking studies and pharmacophore analysis that hydrogen bonding is important for binding to ALK-5.	Hydrogen	70-78	transforming growth factor beta receptor 1	Homo sapiens	115-120
21580655-4	2010	The hexa-fluoro-phosphate anions link the cations into a three-dimensional network via inter-molecular C-H F hydrogen bonds.	Hydrogen	109-117	hexosaminidase subunit alpha	Homo sapiens	4-8
23554623-5	2010	RESULTS: At 1h reperfusion post-ischemia, JNK reached its peak activity while ERK was undergoing a sharp inactivation (P &lt; 0.05).	Hydrogen	12-14	mitogen-activated protein kinase 8	Rattus norvegicus	42-45
20449260-0	2010	Activation of H2 by a highly distorted Rh(II) complex with a new C3-symmetric tripodal tetraphosphine ligand.	Hydrogen	14-16	Rh blood group D antigen	Homo sapiens	39-45
2356159-0	1990	1H-NMR studies of [Sar1]angiotensin II conformation by nuclear Overhauser effect spectroscopy in the rotating frame (ROESY): clustering of the aromatic rings in dimethylsulfoxide.	Hydrogen	0-2	secretion associated Ras related GTPase 1A	Homo sapiens	19-38
2315306-4	1990	We have identified a steroid 21-hydroxylase [steroid, hydrogen-donor:oxygen oxidoreductase (21-hydroxylating), EC 1.14.99.10] deficiency patient who has a maternally inherited disease haplotype that carries a de novo deletion of a ca.	Hydrogen	54-62	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	21-43
2081269-1	1990	Through control of both the nmr probe temperature and of the solvent viscosity, phase-sensitive two-dimensional 1H nuclear Overhauser data (NOESY) at 300 and 500 MHz are obtained with excellent signal-to-noise ratios for Lewis blood group penta- and hexasaccharides isolated from human milk.	Hydrogen	112-114	fucosyltransferase 3 (Lewis blood group)	Homo sapiens	221-238
28217241-1	2016	The interaction between electrodeposition of Ni and electrolyte breakdown, namely the hydrogen evolution reaction (HER) via H3O+ and H2O reduction, was investigated under well-defined mass transport conditions using ultramicroelectrodes (UME"s) coupled with optical imaging, generation/collection scanning electrochemical microscopy (G/C-SECM), and preliminary microscale pH measurements.	Hydrogen	86-94	H3 clustered histone 15	Homo sapiens	124-127
26618241-5	2016	The docking studies also revealed that Leu305, Val458 for TRbeta, and Asp407 for TRalpha are showing hydrogen bonds with the most active inhibitors.	Hydrogen	101-109	T cell receptor alpha locus	Homo sapiens	81-88
27883072-10	2016	The TALEN activity is associated with the inter-repeat hydrogen bonding among the TAL repeats.	Hydrogen	55-63	transaldolase 1	Homo sapiens	4-7
27731877-6	2016	The D168V mutation was shown to interrupt the hydrogen bonding network of Q80R155D168R123 embedded in the extended S2 and partial S4 subsites of the NS3 protein and as a result the R123 side chain was displaced and moved out from the binding pocket.	Hydrogen	46-54	KRAS proto-oncogene, GTPase	Homo sapiens	149-152
27682429-6	2016	An extensive computational study by using a range of DFT methods was performed on 2 TNP and 2+ , and clearly supports the experimentally observed spin flip triggered by hydrogen-bonding interactions.	Hydrogen	169-177	spindlin 1	Homo sapiens	146-150
27682429-7	2016	The counterion is shown to perturb the spin-state ordering through, for example, hydrogen-bonding interactions, switched positions between counterion and axial ligand, ion-pair interactions, and charge polarization.	Hydrogen	81-89	spindlin 1	Homo sapiens	39-43
27524032-6	2016	The complexes 3 and 4 strongly inhibit the topoisomerase I, and also strongly interact with VEGFR2 kinase receptor via pi-pi, sigma-pi and hydrogen bonding interaction.	Hydrogen	139-147	kinase insert domain receptor	Homo sapiens	92-98
27833552-13	2016	H2 blocked the excessive expression of NADPH oxidase and the accumulation of ROS, attenuated the decrease of MMP, and inhibited ROS-sensitive ERK1/2, p38, and JNK signaling pathways.	Hydrogen	0-2	mitogen-activated protein kinase 8	Mus musculus	159-162
27833552-15	2016	H2 exerts its protective effects partially through blocking ROS-sensitive ERK1/2, p38, and JNK signaling pathways.	Hydrogen	0-2	mitogen-activated protein kinase 8	Mus musculus	91-94
29043009-7	2016	Furthermore, the overall rate of hydrogen oxidation is shown to be much higher in [Bmpy][NTf2] than that of [Bmim][NTf2], which is rationalized as the result of both higher solubility of hydrogen and the unique IL-electrode interface structure which promotes the hydrogen adsorption in [Bmpy][NTf2] than that of [Bmim][NTf2].	Hydrogen	33-41	nuclear transport factor 2	Homo sapiens	115-119
29043009-7	2016	Furthermore, the overall rate of hydrogen oxidation is shown to be much higher in [Bmpy][NTf2] than that of [Bmim][NTf2], which is rationalized as the result of both higher solubility of hydrogen and the unique IL-electrode interface structure which promotes the hydrogen adsorption in [Bmpy][NTf2] than that of [Bmim][NTf2].	Hydrogen	187-195	nuclear transport factor 2	Homo sapiens	89-93
29043009-7	2016	Furthermore, the overall rate of hydrogen oxidation is shown to be much higher in [Bmpy][NTf2] than that of [Bmim][NTf2], which is rationalized as the result of both higher solubility of hydrogen and the unique IL-electrode interface structure which promotes the hydrogen adsorption in [Bmpy][NTf2] than that of [Bmim][NTf2].	Hydrogen	187-195	nuclear transport factor 2	Homo sapiens	115-119
29043009-7	2016	Furthermore, the overall rate of hydrogen oxidation is shown to be much higher in [Bmpy][NTf2] than that of [Bmim][NTf2], which is rationalized as the result of both higher solubility of hydrogen and the unique IL-electrode interface structure which promotes the hydrogen adsorption in [Bmpy][NTf2] than that of [Bmim][NTf2].	Hydrogen	187-195	nuclear transport factor 2	Homo sapiens	115-119
29043009-7	2016	Furthermore, the overall rate of hydrogen oxidation is shown to be much higher in [Bmpy][NTf2] than that of [Bmim][NTf2], which is rationalized as the result of both higher solubility of hydrogen and the unique IL-electrode interface structure which promotes the hydrogen adsorption in [Bmpy][NTf2] than that of [Bmim][NTf2].	Hydrogen	187-195	nuclear transport factor 2	Homo sapiens	115-119
29043009-7	2016	Furthermore, the overall rate of hydrogen oxidation is shown to be much higher in [Bmpy][NTf2] than that of [Bmim][NTf2], which is rationalized as the result of both higher solubility of hydrogen and the unique IL-electrode interface structure which promotes the hydrogen adsorption in [Bmpy][NTf2] than that of [Bmim][NTf2].	Hydrogen	187-195	nuclear transport factor 2	Homo sapiens	89-93
29043009-7	2016	Furthermore, the overall rate of hydrogen oxidation is shown to be much higher in [Bmpy][NTf2] than that of [Bmim][NTf2], which is rationalized as the result of both higher solubility of hydrogen and the unique IL-electrode interface structure which promotes the hydrogen adsorption in [Bmpy][NTf2] than that of [Bmim][NTf2].	Hydrogen	187-195	nuclear transport factor 2	Homo sapiens	115-119
29043009-7	2016	Furthermore, the overall rate of hydrogen oxidation is shown to be much higher in [Bmpy][NTf2] than that of [Bmim][NTf2], which is rationalized as the result of both higher solubility of hydrogen and the unique IL-electrode interface structure which promotes the hydrogen adsorption in [Bmpy][NTf2] than that of [Bmim][NTf2].	Hydrogen	187-195	nuclear transport factor 2	Homo sapiens	115-119
29043009-7	2016	Furthermore, the overall rate of hydrogen oxidation is shown to be much higher in [Bmpy][NTf2] than that of [Bmim][NTf2], which is rationalized as the result of both higher solubility of hydrogen and the unique IL-electrode interface structure which promotes the hydrogen adsorption in [Bmpy][NTf2] than that of [Bmim][NTf2].	Hydrogen	187-195	nuclear transport factor 2	Homo sapiens	115-119
27711407-0	2016	Initial dissolution of D2O at the gas-liquid interface of the ionic liquid [C4min][NTf2] associated with hydrogen-bond network formation.	Hydrogen	105-113	nuclear transport factor 2	Homo sapiens	83-87
27711407-5	2016	We propose that the associated D2O molecules at the interface of the IL [C4min][NTf2] make a hydrogen-bond network around the [NTf2]- anion before dissolution into the deeper portion of the interface layer.	Hydrogen	93-101	nuclear transport factor 2	Homo sapiens	80-84
27711407-5	2016	We propose that the associated D2O molecules at the interface of the IL [C4min][NTf2] make a hydrogen-bond network around the [NTf2]- anion before dissolution into the deeper portion of the interface layer.	Hydrogen	93-101	nuclear transport factor 2	Homo sapiens	127-131
27782413-1	2016	The addition reactions of chlorine atom with isobutene (i-C4H8) in solid para-hydrogen (p-H2) were investigated with infrared (IR) absorption spectra.	Hydrogen	73-86	polyhomeotic homolog 2	Homo sapiens	88-92
27647193-14	2016	CONCLUSIONS: Hydrogen-rich water may improve serum AMH levels and reduce ovarian GC apoptosis in a mouse immune POF model induced by ZP3.	Hydrogen	13-21	zona pellucida glycoprotein 3	Mus musculus	133-136
27690308-3	2016	Hydrogen/deuterium exchange and chemical cross-linking coupled to mass spectrometry reveal interactions that are essential for CAF-1 function in budding yeast, and importantly indicate that the Cac1 subunit functions as a scaffold within the CAF-1-H3/H4 complex.	Hydrogen	0-8	Rlf2p	Saccharomyces cerevisiae S288C	194-198
27685945-0	2016	Loss of Sodium/Hydrogen Exchanger NHA2 Exacerbates Obesity- and Aging-Induced Glucose Intolerance in Mice.	Hydrogen	15-23	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	Mus musculus	34-38
27685945-1	2016	We previously demonstrated that the sodium/hydrogen exchanger NHA2, also known as NHEDC2 or SLC9B2, is critical for insulin secretion by beta-cells.	Hydrogen	43-51	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	Mus musculus	62-66
27633136-5	2016	Taken together, residues N48 and T49 in H5N1 NS1 act cooperatively to maintain a strong interaction with mAb 2H6 by forming hydrogen bonds with residues found in the heavy chain of the antibody.	Hydrogen	124-132	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	45-48
27537433-0	2016	Effect of Hydrogen Bonds on the Vibrational Relaxation and Orientational Relaxation Dynamics of HN3 and N3(-) in Solutions.	Hydrogen	10-18	MT-RNR2 like 3 (pseudogene)	Homo sapiens	96-99
27486675-3	2016	The interaction of the IL ions of [Rmim][NTf2] with water molecules through hydrogen bonding is suspected to disrupt IL ion layering and precursor film growth on mica.	Hydrogen	76-84	nuclear transport factor 2	Homo sapiens	41-45
27532889-1	2016	Soybean lipoxygenase (SLO) serves as a prototype for fundamental understanding of hydrogen tunneling in enzymes.	Hydrogen	82-90	linoleate 9S-lipoxygenase-4	Glycine max	8-20
26849632-7	2016	Serum cardiac troponin T and S100B measured during earlier post-resuscitation period were markedly reduced in both H2 inhalation and hypothermic groups.	Hydrogen	115-117	S100 calcium binding protein B	Rattus norvegicus	29-34
20151739-0	2010	Cooperative and diminutive hydrogen bonding in Y...HCN...HCN and NCH...Y...HCN trimers (Y=BF,CO,N2).	Hydrogen	27-35	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	51-54
27477688-0	2016	Spin-polarized transport in hydrogen-passivated graphene and silicene nanoribbons with magnetic transition-metal substituents.	Hydrogen	28-36	spindlin 1	Homo sapiens	0-4
20151739-0	2010	Cooperative and diminutive hydrogen bonding in Y...HCN...HCN and NCH...Y...HCN trimers (Y=BF,CO,N2).	Hydrogen	27-35	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	57-60
27163841-0	2016	Solid-state-reaction synthesis of cotton-like CoB alloy at room temperature as a catalyst for hydrogen generation.	Hydrogen	94-102	cob	Gossypium hirsutum	46-49
20151739-0	2010	Cooperative and diminutive hydrogen bonding in Y...HCN...HCN and NCH...Y...HCN trimers (Y=BF,CO,N2).	Hydrogen	27-35	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	57-60
27434555-11	2016	A small amount of AIF expression was found in the nucleus of HG+H2 group, which indicated that high glucose could promote the AIF nuclear translocation, and that hydrogen-rich medium could prevent the process of translocation.	Hydrogen	162-170	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	18-21
20151739-1	2010	A computational study of the cooperative effect of hydrogen bonding in Y...HCN...HCN and its diminutive effect in NCH...Y...HCN (Y=BF,CO,N2) linear complexes relative to the Y...HCN dimer was undertaken at the MP2/6-311++G(2d,2p) level of theory.	Hydrogen	51-59	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	75-78
20151739-1	2010	A computational study of the cooperative effect of hydrogen bonding in Y...HCN...HCN and its diminutive effect in NCH...Y...HCN (Y=BF,CO,N2) linear complexes relative to the Y...HCN dimer was undertaken at the MP2/6-311++G(2d,2p) level of theory.	Hydrogen	51-59	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	81-84
20151739-1	2010	A computational study of the cooperative effect of hydrogen bonding in Y...HCN...HCN and its diminutive effect in NCH...Y...HCN (Y=BF,CO,N2) linear complexes relative to the Y...HCN dimer was undertaken at the MP2/6-311++G(2d,2p) level of theory.	Hydrogen	51-59	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	81-84
27528273-9	2016	Molecular docking showed that the PFASs bind to TTR with their acid group forming a hydrogen bond with K15 and the hydrophobic chain towards the interior.	Hydrogen	84-92	transthyretin	Homo sapiens	48-51
20151739-1	2010	A computational study of the cooperative effect of hydrogen bonding in Y...HCN...HCN and its diminutive effect in NCH...Y...HCN (Y=BF,CO,N2) linear complexes relative to the Y...HCN dimer was undertaken at the MP2/6-311++G(2d,2p) level of theory.	Hydrogen	51-59	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	81-84
27528273-10	2016	PFASs were modeled to bind TBG with their acid group forming a hydrogen bond with R381 and the hydrophobic chain extending towards R378.	Hydrogen	63-71	serpin family A member 7	Homo sapiens	27-30
20151739-2	2010	It was found that the additional hydrogen bond in Y...HCN...HCN leads to an enhanced Y...HCN dissociation energy, extended H-C bond length, and larger redshift of the H-C stretch relative to Y...HCN, while opposite features are observed in NCH...Y...HCN.	Hydrogen	33-41	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	54-57
20151739-2	2010	It was found that the additional hydrogen bond in Y...HCN...HCN leads to an enhanced Y...HCN dissociation energy, extended H-C bond length, and larger redshift of the H-C stretch relative to Y...HCN, while opposite features are observed in NCH...Y...HCN.	Hydrogen	33-41	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	60-63
27374698-6	2016	The results obtained provide experimental support for the strength of hydrogen bonds between the alcohols and the NTf2 and PF6 anions, providing insights into the IL intermolecular interactions, namely by indicating the ability of the alcohols to discriminate the IL anion hydrogen bond basicity.	Hydrogen	273-281	nuclear transport factor 2	Homo sapiens	114-118
20151739-2	2010	It was found that the additional hydrogen bond in Y...HCN...HCN leads to an enhanced Y...HCN dissociation energy, extended H-C bond length, and larger redshift of the H-C stretch relative to Y...HCN, while opposite features are observed in NCH...Y...HCN.	Hydrogen	33-41	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	60-63
28461893-0	2016	Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug.	Hydrogen	104-112	carbonic anhydrase 2	Homo sapiens	27-48
20151739-2	2010	It was found that the additional hydrogen bond in Y...HCN...HCN leads to an enhanced Y...HCN dissociation energy, extended H-C bond length, and larger redshift of the H-C stretch relative to Y...HCN, while opposite features are observed in NCH...Y...HCN.	Hydrogen	33-41	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	60-63
28461893-7	2016	This study not only allows a direct comparison of the hydrogen bonding, protonation states and solvent orientation/displacement of AZM and MZM, but also shows the significant effect that the methyl derivative has on the solvent organization in the hCA II active site.	Hydrogen	54-62	carbonic anhydrase 2	Homo sapiens	248-254
20151739-2	2010	It was found that the additional hydrogen bond in Y...HCN...HCN leads to an enhanced Y...HCN dissociation energy, extended H-C bond length, and larger redshift of the H-C stretch relative to Y...HCN, while opposite features are observed in NCH...Y...HCN.	Hydrogen	33-41	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	60-63
19854260-6	2010	Prior to the observed increase in NT-3 protein levels, the examined catecholamines increased NT-3 mRNA levels with maximal effects observed after 1h (noradrenaline) and 2h (adrenaline and dopamine) of incubation causing 2.4-, 2.6- and 3-fold elevation, respectively.	Hydrogen	146-148	neurotrophin 3	Rattus norvegicus	93-97
27255177-3	2016	We observed that steric shielding of the hydrogen-bond acceptors and donors (HBA and HBD) of compound 1 reduced the multidrug resistance protein 1 (MDR1) efflux ratio; however, the resulting compound 6, a methoxyacetamide derivative, was mainly metabolized by CYP2D6 and CYP2C19 in the in vitro phenotyping study, implying the risk of PK variability based on the genetic polymorphism of the CYPs.	Hydrogen	41-49	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	116-146
19858003-3	2010	In the present study 1h treatment with 25muM etoposide was highly toxic and initiated a double-stranded DNA damage response as reflected by the recruitment of ATM, MDC1 and DNA-PKcs to gammaH2AX foci.	Hydrogen	21-23	ATM serine/threonine kinase	Homo sapiens	159-162
27255177-3	2016	We observed that steric shielding of the hydrogen-bond acceptors and donors (HBA and HBD) of compound 1 reduced the multidrug resistance protein 1 (MDR1) efflux ratio; however, the resulting compound 6, a methoxyacetamide derivative, was mainly metabolized by CYP2D6 and CYP2C19 in the in vitro phenotyping study, implying the risk of PK variability based on the genetic polymorphism of the CYPs.	Hydrogen	41-49	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	148-152
27406992-6	2016	Under solar-light irradiation, the optimized H-TiO2 120(H2-plasma treatment time: 120 min) photocatalysts showed unprecedentedly excellent removal capability for phenol (Ph), reactive black 5(RB 5), rhodamine B (Rho B) and methylene blue (MB) - approximately four-times higher than those of the other photocatalysts (a-TiO2 and P25) - resulting in complete purification of the water.	Hydrogen	56-58	tubulin polymerization promoting protein	Homo sapiens	328-331
19917609-3	2010	X-ray crystal structures of Rhodobacter capsulatus ALAS reveal that a conserved active site serine moves to within hydrogen bonding distance of the phenolic oxygen of the PLP cofactor in the closed substrate-bound enzyme conformation and within 3-4 A of the thioester sulfur atom of bound succinyl-CoA.	Hydrogen	115-123	aminolevulinic acid synthase 1	Mus musculus	51-55
27980998-1	2016	It is of great significance to design a platform with large surface area and high electrical conductivity for poorly conductive catalyst for hydrogen evolution reaction (HER), such as molybdenum sulfide (MoS x ), a promising and cost-effective nonprecious material.	Hydrogen	141-149	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	204-207
27980998-4	2016	For MoS x @GMS/SWCNT hybrid electrode with a low catalyst loading of 32 mug cm-2, the onset potential is near 113 mV versus reversible hydrogen electrode (RHE) and a high current density of  71 mA cm-2 is achieved at 250 mV versus RHE.	Hydrogen	135-143	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	4-7
33810699-2	2021	The 1H NMR spin-lattice relaxation rates R1(omega) probed in the FC measurements for different isotope-labelled compounds are computed from the MD trajectories for broad frequency and temperature ranges.	Hydrogen	4-6	CD1b molecule	Homo sapiens	41-50
33237088-0	2020	CoP and Ni2P implanted in a hollow porous N-doped carbon polyhedron for pH universal hydrogen evolution reaction and alkaline overall water splitting.	Hydrogen	85-93	caspase recruitment domain family member 16	Homo sapiens	0-3
33237088-4	2020	As a result, CoP/Ni2P@HPNCP exhibits excellent pH universal hydrogen evolution reaction activity and alkaline oxygen evolution reaction activity.	Hydrogen	60-68	caspase recruitment domain family member 16	Homo sapiens	13-16
20047317-1	2010	Hydride transfer catalyzed by dihydrofolate reductase (DHFR) has been described previously within an environmentally coupled model of hydrogen tunneling, where protein motions control binding of substrate and cofactor to generate a tunneling ready conformation and modulate the width of the activation barrier and hence the reaction rate.	Hydrogen	134-142	Dihydrofolate reductase	Escherichia coli	30-53
27226426-1	2016	Cyclic pentapeptides (e.g. Ac-(cyclo-1,5)-[KAXAD]-NH2 ; X=Ala, 1; Arg, 2) in water adopt one alpha-helical turn defined by three hydrogen bonds.	Hydrogen	129-137	arginase 2	Homo sapiens	66-72
20047317-1	2010	Hydride transfer catalyzed by dihydrofolate reductase (DHFR) has been described previously within an environmentally coupled model of hydrogen tunneling, where protein motions control binding of substrate and cofactor to generate a tunneling ready conformation and modulate the width of the activation barrier and hence the reaction rate.	Hydrogen	134-142	Dihydrofolate reductase	Escherichia coli	55-59
32890659-9	2020	Molecular docking indicated that the hydrogen bonds between GA and CCF achieved binding with alpha-glucosidase in the form of supramolecular.	Hydrogen	37-45	sucrase isomaltase (alpha-glucosidase)	Mus musculus	93-110
20066268-2	2010	These results have demonstrated that the C-2 hydrogen atom of the imidazolium ring plays a key role as a hydrogen bond donor.	Hydrogen	45-53	complement C2	Homo sapiens	41-44
34929595-3	2022	The hydrogen content in the gas stream was about 26 vol% at 600 oC for non-catalytic pyrolysis, which increased to around 55 vol% at the expense of light hydrocarbons such as methane and C2-4 for the catalytic process with the biochar/mask ratio of 3.	Hydrogen	4-12	complement C2	Homo sapiens	187-191
27394107-1	2016	We have employed electron bombardment during matrix deposition of CO2 (or (13)CO2, C(18)O2) and para-hydrogen (p-H2) at 3.2 K and recorded infrared (IR) spectra of t-HOCO(+), H(+)(CO2)2, HCO2 (-), CO2 (-), t-HOCO, and other species isolated in solid p-H2.	Hydrogen	101-109	polyhomeotic homolog 2	Homo sapiens	111-115
26808919-2	2016	Specifically, in all of biology, the quinone-binding subunit of Complex I, NuoD, is most closely related to the proton-reducing, H2-evolving [NiFe]-containing catalytic subunit, MbhL, of membrane-bound hydrogenase (MBH), to the methanophenzine-reducing subunit of a methanogenic respiratory complex (FPO) and to the catalytic subunit of an archaeal respiratory complex (MBX) involved in reducing elemental sulfur (S ).	Hydrogen	129-131	diencephalon/mesencephalon homeobox 1	Homo sapiens	370-373
34742064-4	2022	Interestingly, experimental and theoretical calculations showed that the crystalline AB stacking CTF-1 possessed a much higher activity for photochemical hydrogen evolution (362 mumol g-1 h-1) than AA stacking CTF-1 (70 micromol h-1 g-1) for the first time.	Hydrogen	154-162	cardiotrophin 1	Homo sapiens	97-102
20066268-2	2010	These results have demonstrated that the C-2 hydrogen atom of the imidazolium ring plays a key role as a hydrogen bond donor.	Hydrogen	105-113	complement C2	Homo sapiens	41-44
27419582-0	2016	Nonvortical Rashba Spin Structure on a Surface with C_{1h} Symmetry.	Hydrogen	55-57	spindlin 1	Homo sapiens	19-23
20014841-1	2010	A novel inverse CeO(2)/CuO catalyst for preferential oxidation of CO in H(2)-rich stream (CO-PROX) has been developed on the basis of a hypothesis extracted from previous work of the group (JACS 2007, 129, 12064).	Hydrogen	72-76	pyruvate dehydrogenase complex component X	Homo sapiens	93-97
27419582-4	2016	This novel nonvortical RB spin structure is confirmed as a general phenomenon originating from the C_{1h} symmetry of the surface.	Hydrogen	102-104	spindlin 1	Homo sapiens	26-30
27281194-6	2016	Both METTL3 and METTL14 adopt a class I MTase fold and they interact with each other via an extensive hydrogen bonding network, generating a positively charged groove.	Hydrogen	102-110	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	16-23
34962791-3	2022	In this work, we elucidate how multivalent cations (Li+, Cs+, Be2+, Mg2+, Ca2+, Ba2+, Al3+, Nd3+, and Ce3+) affect CO2RR and the competing hydrogen evolution by studying these reactions on polycrystalline gold at pH = 3.	Hydrogen	139-147	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	92-95
20014841-2	2010	Possible separation of the two competing oxidation reactions involved in the process (of CO and H(2), respectively) is the key to modulation of overall CO-PROX activity and is based on involvement of different sites as most active ones for each of the two reactions.	Hydrogen	96-100	pyruvate dehydrogenase complex component X	Homo sapiens	155-159
26614329-1	2010	A new method is presented that improves the supermolecular second-order Moller-Plesset (MP2) method for dimer systems with strong dispersion interactions while preserving the generally good performance of MP2 for other types of intermolecular interactions, e.g., hydrogen-bonded systems.	Hydrogen	263-271	tryptase pseudogene 1	Homo sapiens	88-91
34952337-6	2022	However, pi-pi interactions as well as hydrogen bonds between protein and DOXs were mediated by the basic and acidic amino acids such as HIP128, GLU17, and LYS143 at the open pores, providing penetration of DOXs into the H-Apo-Fr.	Hydrogen	39-47	ferritin heavy chain 1	Homo sapiens	223-229
34955208-0	2022	One-pot molten salt method for constructing CdS/C3N4 nanojunctions with highly enhanced photocatalytic performance for hydrogen evolution reaction.	Hydrogen	119-127	CDP-diacylglycerol synthase 1	Homo sapiens	44-47
34955208-3	2022	The as-prepared CdS/C3N4 materials exhibit high efficiency for photocatalytic hydrogen evolution reaction (HER) with the HER rate as high as 15,866 mumol/(g hr) under visible light irradiation (lambda > 420 nm), which is 89 and 9 times those of pristine C3N4 and CdS, respectively.	Hydrogen	78-86	CDP-diacylglycerol synthase 1	Homo sapiens	16-19
34932320-1	2022	Hydrogen sensing is extremely essential for hydrogen-related applications due to the explosibility of hydrogen gas (H2).	Hydrogen	0-8	gastrin	Homo sapiens	111-114
34932320-1	2022	Hydrogen sensing is extremely essential for hydrogen-related applications due to the explosibility of hydrogen gas (H2).	Hydrogen	44-52	gastrin	Homo sapiens	111-114
34932320-1	2022	Hydrogen sensing is extremely essential for hydrogen-related applications due to the explosibility of hydrogen gas (H2).	Hydrogen	102-110	gastrin	Homo sapiens	111-114
34969976-5	2022	Arg403 in the pore helix of CNGB3 projects into an asymmetric selectivity filter and forms hydrogen bonds with two pore-lining backbone carbonyl oxygens.	Hydrogen	91-99	cyclic nucleotide gated channel subunit beta 3	Homo sapiens	28-33
34908408-5	2021	Molecular dynamics (MD) simulation suggested, for PD-L1, the long sequence could supply more noncovalent bonds including hydrogen bonds, electrostatic interactions, and hydrophobic interactions to form a stable protein/aptamer complex.	Hydrogen	121-129	CD274 molecule	Homo sapiens	50-55
34953939-0	2022	Hydrogen attenuated inflammation response and oxidative in hypoxic ischemic encephalopathy via Nrf2 mediated the inhibition of NLRP3 and NF-kappaB.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	127-132
34953939-13	2022	In addition, the absence of Nrf2 abolished the suppressive effect of hydrogen on the expression of Nacht, Lrr, and Pyd domains-containing protein 3 (NLRP3) pathway members and p65 NF-kappaB after HI.	Hydrogen	69-77	NLR family, pyrin domain containing 3	Mus musculus	99-147
34953939-13	2022	In addition, the absence of Nrf2 abolished the suppressive effect of hydrogen on the expression of Nacht, Lrr, and Pyd domains-containing protein 3 (NLRP3) pathway members and p65 NF-kappaB after HI.	Hydrogen	69-77	NLR family, pyrin domain containing 3	Mus musculus	149-154
34953939-13	2022	In addition, the absence of Nrf2 abolished the suppressive effect of hydrogen on the expression of Nacht, Lrr, and Pyd domains-containing protein 3 (NLRP3) pathway members and p65 NF-kappaB after HI.	Hydrogen	69-77	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	176-189
34953939-14	2022	Taken together, our findings showed that hydrogen alleviated cellular injury and apoptosis, neurobehavioural deficits, the inflammatory response and oxidative stress via the Nrf2-mediated NLRP3 and NF-kappaB pathways.	Hydrogen	41-49	NLR family, pyrin domain containing 3	Mus musculus	188-193
34975848-6	2021	In silico analysis revealed that a hydrogen bond present between Gly65 and Leu69 in the wild-type TTC7A was disrupted by the Leu69Pro mutation.	Hydrogen	35-43	tetratricopeptide repeat domain 7A	Homo sapiens	98-103
34879065-5	2021	The structure of the AUP1 G2BR (G2BRAUP1) in complex with UBE2G2 reveals an interface that includes a network of salt bridges, hydrogen bonds, and hydrophobic interactions essential for AUP1 function in cells.	Hydrogen	127-135	AUP1 lipid droplet regulating VLDL assembly factor	Homo sapiens	21-25
34739254-2	2021	Their single-crystal structures show that all neutral complexes (Ir1, Ir2, and Ir3) show a trans-N^N configuration between dianionic (-2) and monoanionic (-1) ligands, which is in contrast with the trans-N^C configuration in cationic complex Ir4, which has an interesting hydrogen bond in the solid state.	Hydrogen	272-280	nischarin	Homo sapiens	65-68
34792337-4	2021	These compounds also exhibit large surface areas after evacuation of the DMF molecules and also moderate amounts of hydrogen gas uptake at 77 K. The luminescence properties were investigated for Eu and Tb analogues at elevated temperatures, at which an unusual increase in the emission intensity was observed upon the release of solvents, and discussed based on their porous structure.	Hydrogen	116-124	gastrin	Homo sapiens	125-128
34812037-0	2021	Tuning the Electronic Structure of the CoP/Ni2P Nanostructure by Nitrogen Doping for an Efficient Hydrogen Evolution Reaction in Alkaline Media.	Hydrogen	98-106	caspase recruitment domain family member 16	Homo sapiens	39-42
34812037-4	2021	The prepared N-CoP/Ni2P@NF exhibits excellent electrocatalytic hydrogen evolution reaction (HER) performance, which merely requires an overpotential of -46 mV at -10 mA cm-2 and shows a negligible decay after a long durability test for 72 h in alkaline (1.0 M KOH) media.	Hydrogen	63-71	caspase recruitment domain family member 16	Homo sapiens	15-18
34787391-0	2021	Structural and Componential Engineering of Co2P&CoP@N-C Nanoarrays for Energy-Efficient Hydrogen Production from Water Electrolysis.	Hydrogen	88-96	complement C2	Homo sapiens	43-46
33307873-7	2021	Docking experiments suggest that 1 preferably interact with the site 2 of alpha-synuclein through hydrogen bonds with residues Y39 and T44.	Hydrogen	98-106	synuclein alpha	Homo sapiens	74-89
34741432-0	2021	In Situ Replacement Synthesis of Co@NCNT Encapsulated CoPt3 @Co2 P Heterojunction Boosting Methanol Oxidation and Hydrogen Evolution.	Hydrogen	114-122	complement C2	Homo sapiens	61-64
34741432-3	2021	Theoretical calculations confirm that electrons at the interfaces transfer from CoPt3 to Co2 P, where electron hole region on CoPt3 is beneficial to improving the MOR activity, whereas accumulation region on Co2 P favors to the optimization of H2 O and H* absorption energies for hydrogen evolution reaction (HER).	Hydrogen	280-288	complement C2	Homo sapiens	89-92
34741432-3	2021	Theoretical calculations confirm that electrons at the interfaces transfer from CoPt3 to Co2 P, where electron hole region on CoPt3 is beneficial to improving the MOR activity, whereas accumulation region on Co2 P favors to the optimization of H2 O and H* absorption energies for hydrogen evolution reaction (HER).	Hydrogen	280-288	complement C2	Homo sapiens	208-211
34832131-0	2021	Incorporation of Au Nanoparticles on ZnO/ZnS Core Shell Nanostructures for UV Light/Hydrogen Gas Dual Sensing Enhancement.	Hydrogen	84-92	gastrin	Homo sapiens	93-96
34832131-4	2021	Furthermore, our findings show that the addition of Au NPs could enhance both 365 nm UV light sensing and hydrogen gas sensing in terms of light/gas sensitivity and light/gas response time.	Hydrogen	106-114	gastrin	Homo sapiens	115-118
34832131-4	2021	Furthermore, our findings show that the addition of Au NPs could enhance both 365 nm UV light sensing and hydrogen gas sensing in terms of light/gas sensitivity and light/gas response time.	Hydrogen	106-114	gastrin	Homo sapiens	145-148
34832131-4	2021	Furthermore, our findings show that the addition of Au NPs could enhance both 365 nm UV light sensing and hydrogen gas sensing in terms of light/gas sensitivity and light/gas response time.	Hydrogen	106-114	gastrin	Homo sapiens	171-174
34730159-0	2021	MoP@MoO3 S-scheme heterojunction in situ construction with phosphating MoO3 for high-efficient photocatalytic hydrogen production.	Hydrogen	110-118	opioid receptor mu 1	Homo sapiens	0-3
34730159-5	2021	The interface interaction dominated by chemical bonds has a stronger interface interaction force, which can promote the interface charge transfer leading to optimizing the MoP@MoO3 core-shell composite material, adjusting the quality of sodium hypophosphite, and phosphating MoO3 to varying degrees, producing the best hydrogen production H2 evolution rate is 10 000.02 mumol h-1 g-1.	Hydrogen	319-327	opioid receptor mu 1	Homo sapiens	172-175
27275633-5	2016	One exception is complex 9, which has a near-zero activation entropy and is proposed to undergo ligand-arm dissociation during the RDS to accommodate H2(18)O binding.	Hydrogen	150-152	peripherin 2	Homo sapiens	131-134
27033324-5	2016	The SOAT pharmacophore features were calculated by CATALYST and consist of three hydrophobic sites and two hydrogen bond acceptors.	Hydrogen	107-115	solute carrier family 10 member 6	Homo sapiens	4-8
27038848-4	2016	The molecular docking studies of AA indicated that the hydroxyl group at C2 of the A-ring, which hydrogen bonds with the catalytic site residues (His64, Asn62 and Asn67), along with the gem-dimethyl group at C20 of the E-ring, greatly influences the inhibitory activity, independent of the catalytic zinc, unlike the inhibition observed with most CA II inhibitors.	Hydrogen	97-105	carbonic anhydrase 2	Homo sapiens	347-352
26990621-9	2016	KEY RESULTS: CX08005 competitively inhibited PTP1B by binding to the catalytic P-loop through hydrogen bonds.	Hydrogen	94-102	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	45-50
26784277-12	2016	CD11b expression on CD14 CD16 was significantly greater at IP (P &lt; 0.014) and 1H (P = 0.009).	Hydrogen	81-83	integrin subunit alpha M	Homo sapiens	0-5
26784277-12	2016	CD11b expression on CD14 CD16 was significantly greater at IP (P &lt; 0.014) and 1H (P = 0.009).	Hydrogen	81-83	Fc gamma receptor IIIa	Homo sapiens	25-29
27179492-6	2016	In MFE and DFE, the CF3 group of C153 prefers to have a CF2-F H -(CHF) type of electrostatic interaction over CF2-F F -(CH2) kind of dispersion interaction which increases the rate of nonradiative decay, probably due to the electrostatic nature of the CF2-F H -(CHF) hydrogen bond.	Hydrogen	267-275	ATPase H+ transporting accessory protein 1	Homo sapiens	110-113
27179492-6	2016	In MFE and DFE, the CF3 group of C153 prefers to have a CF2-F H -(CHF) type of electrostatic interaction over CF2-F F -(CH2) kind of dispersion interaction which increases the rate of nonradiative decay, probably due to the electrostatic nature of the CF2-F H -(CHF) hydrogen bond.	Hydrogen	267-275	ATPase H+ transporting accessory protein 1	Homo sapiens	110-113
26966273-8	2016	Mutagenesis of Y322, which is the putative hydrogen bond partner of Y157, also reduced PAR4 surface expression in HEK293 cells.	Hydrogen	43-51	F2R like thrombin or trypsin receptor 3	Homo sapiens	87-91
26966273-9	2016	CONCLUSIONS: Reduced PAR4 responses associated with Y157C result from aberrant anterograde surface receptor trafficking, in part, because of disrupted intramolecular hydrogen bonding.	Hydrogen	166-174	F2R like thrombin or trypsin receptor 3	Homo sapiens	21-25
27118147-5	2016	For the most active compound 20, we confirmed that it is a specific MD2 inhibitor through a series of biochemical experiments and elucidated that it binds to the hydrophobic pocket of MD2 via hydrogen bonds with Arg(90) and Tyr(102) residues.	Hydrogen	192-200	lymphocyte antigen 96	Rattus norvegicus	68-71
27118147-5	2016	For the most active compound 20, we confirmed that it is a specific MD2 inhibitor through a series of biochemical experiments and elucidated that it binds to the hydrophobic pocket of MD2 via hydrogen bonds with Arg(90) and Tyr(102) residues.	Hydrogen	192-200	lymphocyte antigen 96	Rattus norvegicus	184-187
26987665-4	2016	Low H2 partial pressure (PH2) tends to result in fast growth of dendritically shaped GSCs with multiple small adlayers, but high PH2 can modify the GSC shape into hexagons with single large adlayer nuclei.	Hydrogen	4-6	polyhomeotic homolog 2	Homo sapiens	25-28
26795953-9	2016	The results showed that PDGF-BB significantly increased PRMT1 expression after 1h lasting over 48h, through ERK1/2 MAPK and STAT1 signaling.	Hydrogen	79-81	protein arginine methyltransferase 1	Homo sapiens	56-61
26859865-1	2016	SABRE (Signal Amplification By Reversible Exchange) nuclear spin hyperpolarization method can provide strongly enhanced NMR signals as a result of the reversible association of small molecules with para-hydrogen (p-H2) at an iridium metal complex.	Hydrogen	198-211	polyhomeotic homolog 2	Homo sapiens	213-217
26860583-7	2016	Notably, both hydrogen/deuterium exchange experiments and in vitro binding assays demonstrate that Lsm11, in addition to interacting with the N-terminal region of FLASH, also contacts the C-terminal SANT/Myb-like domain of FLASH, the same region that binds NPAT.	Hydrogen	14-22	LSM11, U7 small nuclear RNA associated	Homo sapiens	99-104
26854023-0	2016	A Binding Site on IL-17A for Inhibitory Macrocycles Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry.	Hydrogen	64-72	interleukin 17A	Homo sapiens	18-24
29917336-14	2016	Conclusion: Hydrogen-rich medium can effectively attenuate LPS-induced dysfunction of intestinal epithelial barrier in human Caco2 cells by ameliorating cell viability as well as regulating claudin-1 and occludin expression and structure.	Hydrogen	12-20	claudin 1	Homo sapiens	190-199
26677223-6	2016	The enhanced stability stems from the steric consequences of adding a side chain (G1324A) and additionally a hydrogen bond (G1324S) to His(1322) across the beta2-beta3 hairpin in the GPIbalpha binding interface, which restrains the conformational degrees of freedom and the overall flexibility of the native state.	Hydrogen	109-117	glycoprotein Ib platelet subunit alpha	Homo sapiens	183-192
28808527-6	2016	The crystal structure of its complex with VDR ligand binding domain reveals its binding mechanism involving boron-mediated dihydrogen bonds that mimic vitamin D hydroxyl interactions.	Hydrogen	123-133	vitamin D receptor	Homo sapiens	42-45
31968761-1	2016	A well-defined PN3 -Ru pincer complex (5) bearing a redox-active bipyridine ligand with an aminophosphine arm has been established as an effective and stable molecular electrocatalyst for CO2 reduction to CO and HCOOH with negligible formation of H2 in a H2 O/MeCN mixture.	Hydrogen	247-249	sodium voltage-gated channel alpha subunit 10	Homo sapiens	15-18
26638009-0	2016	Second sphere control of spin state: Differential tuning of axial ligand bonds in ferric porphyrin complexes by hydrogen bonding.	Hydrogen	112-120	spindlin 1	Homo sapiens	25-29
26869763-9	2016	Fourier transform infrared spectroscopy and differential scanning calorimetry proved that PLs formed hydrogen bonds with the amide group of CTS and the hydroxyl group of beta-CD.	Hydrogen	101-109	transthyretin	Homo sapiens	140-143
26600122-2	2016	It is believed that the interaction, of both hydrogen bonding and electrostatic nature, involves a partly protonated form of Mozobil( ), LHn(n+) and the COO(-) groups of Asp(171) and Asp(262) residues protruding from the walls of the pocket of the membrane protein CXCR4.	Hydrogen	45-53	C-X-C motif chemokine receptor 4	Homo sapiens	265-270
26600122-6	2016	It is finally suggested that, in the pocket of the CXCR4 membrane protein, Mozobil( ) operates as a pentammonium cation, which establishes with carboxylate groups of Asp(171) and Asp(262) strong interactions of hydrogen bonding and electrostatic nature.	Hydrogen	211-219	C-X-C motif chemokine receptor 4	Homo sapiens	51-56
26784025-10	2016	Several important hydrogen bonds with Btk were revealed, which includes the gatekeeper residues Glu475 and Met 477 at the hinge region.	Hydrogen	18-26	Bruton tyrosine kinase	Homo sapiens	38-41
26762452-0	2016	Cosmology: Photons from dwarf galaxy zap hydrogen.	Hydrogen	41-49	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	37-40
26747816-3	2016	The latter sequence arises because PH2 fragments are surprisingly mobile on Si(001) and can diffuse away from the third hydrogen atom that makes up the PH3 stoichiometry.	Hydrogen	120-128	polyhomeotic homolog 2	Homo sapiens	35-38
26985305-2	2016	When cocrystallized with CDK8 and cyclin C, these compounds exhibit an unusual binding mode, making a single hydrogen bond to the hinge residue A100, a second to K252, and a key cation-pi interaction with R356.	Hydrogen	109-117	cyclin C	Homo sapiens	34-42
26889236-5	2016	The results showed that hydrogen-rich saline significantly decreased the levels of VEGF, TM and LPO and increased the GSH level in steroid-associated necrosis of the femoral head in the rabbit model.	Hydrogen	24-32	vascular endothelial growth factor A	Oryctolagus cuniculus	83-87
27931558-7	2016	A recent study has demonstrated that hs-cTnI can further reduce the time to 1h in 70% of all patients with chest pain.	Hydrogen	76-78	troponin I3, cardiac type	Homo sapiens	40-44
27096472-5	2016	Hydrogen bond interactions between the compound and key active site residues of TDO, freedom upon rotation of the C3 chemical moiety and the presence of chlorines in the benzene ring of the compound comprise the properties that an isatin-based inhibitor requires to effectively inhibit the enzymatic activity of TDO.	Hydrogen	0-8	tryptophan 2,3-dioxygenase	Homo sapiens	80-83
27096472-5	2016	Hydrogen bond interactions between the compound and key active site residues of TDO, freedom upon rotation of the C3 chemical moiety and the presence of chlorines in the benzene ring of the compound comprise the properties that an isatin-based inhibitor requires to effectively inhibit the enzymatic activity of TDO.	Hydrogen	0-8	tryptophan 2,3-dioxygenase	Homo sapiens	312-315
19857500-11	2010	However, we observed a 2 -A translation of the R17-hSfi1-20 helix along its axis, inducing less anchorage in the protein and the disruption of a hydrogen bond between a tryptophan residue in the peptide and a well-conserved nearby glutamate in C-HsCen2.	Hydrogen	145-153	SFI1 centrin binding protein	Homo sapiens	51-56
19876967-4	2010	The beta N--O turns or beta N--O helices, which feature nine-membered rings with intramolecular hydrogen bonds and have been identified previously in peptides of beta(3)- and beta(2, 2)-aminoxy acids, are also predominantly present in the acyclic beta(2, 3)-aminoxy peptides with a syn configuration and N--O bonds gauche to the C(alpha)--C(beta) bonds in both solution and the solid state.	Hydrogen	96-104	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	162-179
27748183-3	2016	Upon the generation of Tyr385 radical, COX catalysis is initiated, with C13 pro-S hydrogen abstraction from AA by Tyr385 radical to generate arachidonyl substrate radical.	Hydrogen	82-90	homeobox C13	Homo sapiens	72-75
19876967-4	2010	The beta N--O turns or beta N--O helices, which feature nine-membered rings with intramolecular hydrogen bonds and have been identified previously in peptides of beta(3)- and beta(2, 2)-aminoxy acids, are also predominantly present in the acyclic beta(2, 3)-aminoxy peptides with a syn configuration and N--O bonds gauche to the C(alpha)--C(beta) bonds in both solution and the solid state.	Hydrogen	96-104	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	247-256
19896391-1	2010	The fragmentation of the totally deuterated dinucleotide dAT(-) in labile positions (heteroatom-bound hydrogens) was compared for different MS/MS methods: CID, IRMPD, and EID.	Hydrogen	102-111	Dopamine transporter	Drosophila melanogaster	57-60
26595893-6	2015	Folding Lp-PLA2 was simulated using GROMACS software by assessing helicity, hydrogen bond formation and stability.	Hydrogen	76-84	phospholipase A2 group VII	Homo sapiens	8-15
26507163-6	2015	mRNA and protein expressions of IL-1beta and IL-8 decreased significantly when pretreated HCECs with recombinant human SP-D for 4h before A. fumigatus stimulation, while IL-1beta and IL-8 increased when pretreated with SP-D antibody for 1h.	Hydrogen	237-239	surfactant protein D	Homo sapiens	119-123
21491695-6	2010	As experimentally observed, weak hydrogen bond donors form weak hydrogen bond complexes, called HBC.	Hydrogen	33-41	keratin 88, pseudogene	Homo sapiens	96-99
26491845-6	2015	JNK was activated within 1h while liver damage was maximal at 24h post-CCl4 injection.	Hydrogen	25-27	mitogen-activated protein kinase 8	Mus musculus	0-3
21491695-6	2010	As experimentally observed, weak hydrogen bond donors form weak hydrogen bond complexes, called HBC.	Hydrogen	64-72	keratin 88, pseudogene	Homo sapiens	96-99
26612539-6	2015	Rather than classical stacking interactions that occur across nitrogen bases and aromatic amino acids on ribonucleoprotein sites, moderate-affinity hydrogen bonding network between the nitrogen bases in the stem-loop RNA and a concave face on the RRM surface primarily mediate TAF15-RRM RNA interaction.	Hydrogen	148-156	TATA-box binding protein associated factor 15	Homo sapiens	277-282
19373825-6	2009	The calculation results show that the potential energy curves obtained from the analytic function are in good agreement with those obtained from MP2/6-31+G** calculations by including the BSSE correction, which demonstrate that the analytic function proposed in this work can be used to predict the hydrogen-bonding interaction energies in peptides quickly and accurately.	Hydrogen	299-307	tryptase pseudogene 1	Homo sapiens	145-153
26503048-5	2015	Here we describe the rhodium-catalysed carboamination of alkenes at the same (syn) face of a double bond, initiated by a carbon-hydrogen activation event that uses enoxyphthalimides as the source of both the carbon and the nitrogen functionalities.	Hydrogen	128-136	synemin	Homo sapiens	78-81
26528963-7	2015	Binding to Gln177 of the second extracellular loop region via hydrogen bonds is likely to be essential for alpha1A-selective antagonists.	Hydrogen	62-70	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	107-114
26495970-6	2015	HS produced glomerular hypertrophy and decreased ACE2 and nephrin expressions, loss of morphological integrity of the podocyte processes, and increased proteinuria, characterized by loss of albumin and high molecular weight proteins.	Hydrogen	0-2	angiotensin I converting enzyme 2	Rattus norvegicus	49-53
19759001-7	2009	A 2.5 A crystal structure of the R229W variant shows that the substitution of Arg-229 at the FMN binding site has led to a loss of hydrogen-bond and/or salt-bridge interactions between FMN and Arg-229 and Ser-175.	Hydrogen	131-139	formin 1	Homo sapiens	93-96
27478268-1	2015	Insights into the mechanism of the unusual trans-hydrogenation of internal alkynes catalyzed by {Cp*Ru} complexes were gained by para-hydrogen (p-H2) induced polarization (PHIP) transfer NMR spectroscopy.	Hydrogen	129-142	polyhomeotic homolog 2	Homo sapiens	144-148
20183496-1	2009	The SPARC software program was validated for nitrogen-hydrogen acidity constant estimation of primary and secondary sulfonamides against a broad suite of substituted derivatives with experimental datasets in water and dimethylsulfoxide solvent systems and across a wide pK(a) range.	Hydrogen	54-62	secreted protein acidic and cysteine rich	Homo sapiens	4-9
18701327-4	2009	Canine MITF-M, MITF-H, and MITF-A were highly homologous to the nucleotide sequences in isoform-specific 1M, 1H, and 1A with 100%, 98%, and 97% identity in humans, respectively.	Hydrogen	109-111	melanocyte inducing transcription factor	Canis lupus familiaris	7-13
34714942-3	2022	A combination of steady-state electronic spectroscopy, femtosecond transient absorption, ground-state femtosecond stimulated Raman spectroscopy (FSRS), and quantum calculations elucidates an intermolecular hydrogen-bonding chain between a solvent -OH group and the chromophore phenolic ring -NMe2 and -OH functional groups, wherein fluorescence differences arise from an extended hydrogen-bonding network beyond the first solvation shell, as opposed to fluorescence quenching via a dark twisted intramolecular charge transfer state.	Hydrogen	206-214	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	292-296
34714942-3	2022	A combination of steady-state electronic spectroscopy, femtosecond transient absorption, ground-state femtosecond stimulated Raman spectroscopy (FSRS), and quantum calculations elucidates an intermolecular hydrogen-bonding chain between a solvent -OH group and the chromophore phenolic ring -NMe2 and -OH functional groups, wherein fluorescence differences arise from an extended hydrogen-bonding network beyond the first solvation shell, as opposed to fluorescence quenching via a dark twisted intramolecular charge transfer state.	Hydrogen	380-388	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	292-296
18701327-4	2009	Canine MITF-M, MITF-H, and MITF-A were highly homologous to the nucleotide sequences in isoform-specific 1M, 1H, and 1A with 100%, 98%, and 97% identity in humans, respectively.	Hydrogen	109-111	melanocyte inducing transcription factor	Canis lupus familiaris	7-11
34663815-5	2021	Hydrogen-deuterium exchange reveals multiple calcineurin-PI4KA complex contacts, including a calcineurin-binding peptide motif in the disordered tail of FAM126A, which we establish as a calcineurin substrate.	Hydrogen	0-8	family with sequence similarity 126 member A	Homo sapiens	153-160
19812846-1	2009	High concentrations of molecular hydrogen adsorption on MOF-5 were evaluated at the semiempirical PM6 (periodic and cluster) and ab initio MP2 (cluster) theoretical levels.	Hydrogen	33-41	tryptase pseudogene 1	Homo sapiens	139-142
34682298-6	2021	The relative tight binding might result from a hydrogen bond interaction of the three compounds with a Tyr444 residue in hMAO-A, whereas no hydrogen bond interaction was proposed in hMAO-B.	Hydrogen	47-55	monoamine oxidase A	Homo sapiens	121-127
19791743-5	2009	Modeling of the binding mode of 67 suggests that the cyanoguanidine moiety forms charge-assisted hydrogen bonds not only with the conserved Asp-94 but also with the hH4R-specific Arg-341 residue.	Hydrogen	97-105	histamine receptor H4	Homo sapiens	165-169
34515295-8	2021	Furthermore, we found that DJ-1 C46A mutant has distorted unstable structure identified by biochemical assay and employing hydrogen/deuterium exchange-mass spectrometry (HDX-MS) analysis.	Hydrogen	123-131	Parkinsonism associated deglycase	Homo sapiens	27-31
19968123-5	2009	The results of artificial wastewater treatment showed after 1h inoculation, the concentration of poly-phosphate in KT2440-PPK came to the maximum approximately 3.05 mg/g, which was 15 times higher than that in KT2440 at the same experimental condition.	Hydrogen	60-62	polyphosphate kinase 1	Pseudomonas putida KT2440	122-125
34606263-3	2021	Molecular docking revealed an additional nonclassical hydrogen-bonding (NCHB) interaction between the unique 7-aminoquinazoline scaffold and the CSF1R hinge region, contributing to CSF1R potency enhancement.	Hydrogen	54-62	colony stimulating factor 1 receptor	Mus musculus	145-150
34606263-3	2021	Molecular docking revealed an additional nonclassical hydrogen-bonding (NCHB) interaction between the unique 7-aminoquinazoline scaffold and the CSF1R hinge region, contributing to CSF1R potency enhancement.	Hydrogen	54-62	colony stimulating factor 1 receptor	Mus musculus	181-186
19743837-9	2009	Taken together, the data suggest a model for putative hydrogen bond interactions of the conserved polar residues in the transmembrane domain of native, oligomeric NTPDase3.	Hydrogen	54-62	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	163-171
34605652-5	2021	Specifically, the obtained Pt1@Co/NC catalyst displays a remarkable performance for ORR, achieving mass activity of 4.2 mA mugPt-1 (28 times higher than that of commercial Pt/C) at 0.9 V versus reversible hydrogen electrode (RHE) in 0.1 M HClO4 solution with high stability over 30000 cycles.	Hydrogen	205-213	zinc finger protein 77	Homo sapiens	27-30
19655253-7	2009	The inhibited structure of caspase-7/YVAD shows that the P4 Tyr binds the S4 region specific to polar residues at the expense of a main chain hydrogen bond between the P4 amide and carbonyl oxygen of caspase-7 Gln 276, which is similar to the caspase-3 complex.	Hydrogen	142-150	caspase 7	Homo sapiens	27-36
34524798-5	2021	Then, the chain propagates via a general C CHR + CH2 coupling and subsequent hydrogen-assisted isomerization of the resulting allene ligand mu-eta1:eta3-H2C C CHR to a higher vinylidene homologue mu-eta1:eta1-C CH(CH2)R. By repeating this reaction sequence, up to C6 chains have been synthesized in a stepwise fashion.	Hydrogen	77-85	secreted phosphoprotein 1	Homo sapiens	143-147
34524798-5	2021	Then, the chain propagates via a general C CHR + CH2 coupling and subsequent hydrogen-assisted isomerization of the resulting allene ligand mu-eta1:eta3-H2C C CHR to a higher vinylidene homologue mu-eta1:eta1-C CH(CH2)R. By repeating this reaction sequence, up to C6 chains have been synthesized in a stepwise fashion.	Hydrogen	77-85	secreted phosphoprotein 1	Homo sapiens	204-208
19655253-7	2009	The inhibited structure of caspase-7/YVAD shows that the P4 Tyr binds the S4 region specific to polar residues at the expense of a main chain hydrogen bond between the P4 amide and carbonyl oxygen of caspase-7 Gln 276, which is similar to the caspase-3 complex.	Hydrogen	142-150	caspase 7	Homo sapiens	200-209
34296809-2	2021	In this work, Ti 3 C 2 T x /CdS nanocomposites were obtained by self-assembly of hexagonal CdS in the presence of preformed Ti 3 C 2 T x nanosheets, which serves as a photocatalyst for acceptorless dehydrogenation of biomass-derived furfuryl alcohol (FOL) to furfural (FAL) and furoic acid (FA) in neutral and alkaline medium respectively, with simultaneous generation of stoichiometric hydrogen under visible light.	Hydrogen	387-395	CDP-diacylglycerol synthase 1	Homo sapiens	28-31
34296809-2	2021	In this work, Ti 3 C 2 T x /CdS nanocomposites were obtained by self-assembly of hexagonal CdS in the presence of preformed Ti 3 C 2 T x nanosheets, which serves as a photocatalyst for acceptorless dehydrogenation of biomass-derived furfuryl alcohol (FOL) to furfural (FAL) and furoic acid (FA) in neutral and alkaline medium respectively, with simultaneous generation of stoichiometric hydrogen under visible light.	Hydrogen	387-395	CDP-diacylglycerol synthase 1	Homo sapiens	91-94
19545598-8	2009	The suppression of the intensity of protein synthesis in CA1 pyramidal neurons 1h after the injection of CHI was more than threefold stronger than in CA3, and by 4h, it was most pronounced in CA3 neurons.	Hydrogen	79-81	carbonic anhydrase 1	Rattus norvegicus	57-60
19739848-2	2009	The dispersion-corrected MP2 (MP2 + Delta vdW) results are in excellent agreement with the quantum chemistry "gold standard" [coupled cluster theory with single, double and perturbative triple excitations, CCSD(T)] for a range of systems bounded by hydrogen bonding, electrostatics and dispersion forces.	Hydrogen	249-257	tryptase pseudogene 1	Homo sapiens	25-28
34516105-1	2021	Substitution of apical halide ligands in ({Re6Sei8}Xa6)3- (X = Cl, Br) by benzimidazole (bimzH) accompanied by a self-assembly process leads to the formation of microporous Re6-based hydrogen-bonded organic frameworks (Re6-HOFs) constructed on N-H   X hydrogen bonds and pi-pi-stacking interactions between bimzH ligands.	Hydrogen	183-191	chromosome 12 open reading frame 73	Homo sapiens	67-69
19739848-2	2009	The dispersion-corrected MP2 (MP2 + Delta vdW) results are in excellent agreement with the quantum chemistry "gold standard" [coupled cluster theory with single, double and perturbative triple excitations, CCSD(T)] for a range of systems bounded by hydrogen bonding, electrostatics and dispersion forces.	Hydrogen	249-257	tryptase pseudogene 1	Homo sapiens	30-33
19574232-5	2009	Analysis of MMP-1/THP interactions by hydrogen/deuterium exchange mass spectrometry followed by evaluation of wild type and mutant MMP-1 kinetics led to the identification of three noncatalytic regions in MMP-1 (residues 285-295, 302-316, and 437-457) and two specific residues (Ile-290 and Arg-291) that participate in collagenolysis.	Hydrogen	38-46	matrix metallopeptidase 1	Homo sapiens	12-17
34286417-6	2021	In this study, we present the backbone 1H, 13C, and 15N resonance assignments of mouse vWF-A2; side chain assignments of 13Cbeta are also provided.	Hydrogen	39-41	Von Willebrand factor	Mus musculus	87-93
19559571-7	2009	RESULTS: HB-EGF-induced phosphorylation of EGFR with maximum phosphorylation at 1h.	Hydrogen	80-82	heparin binding EGF like growth factor	Homo sapiens	9-15
34399250-4	2021	Firstly, the stable binding structure of hBD-3 dimer in analog form bound on POPG lipid bilayer was predicted using NAMD simulations, which was confirmed by RMSD, buried surface area, hydrogen bonds, distance map, and insertion depth map calculations.	Hydrogen	184-192	defensin beta 103B	Homo sapiens	41-46
20055175-3	2009	All five features contained in Hypo-AT(1)-7 and Hypo-ET(A)-1 (hydrogen-bond acceptor (A), hydrophobic aliphatic (Z), negative ionizable (N), ring aromatic (R), and hydrophobic aromatic (Y)) seem to be essential for antagonists in terms of binding activity.	Hydrogen	62-70	secreted phosphoprotein 1	Homo sapiens	53-60
34333372-0	2021	Glutathione produced by gamma-glutamyl cysteine synthetase acts downstream of hydrogen to positively influence lateral root branching.	Hydrogen	78-86	glutamate-cysteine ligase	Arabidopsis thaliana	24-58
34460229-7	2021	This demonstrated strategy can raise a common methodology in the synthesis of single-tip semiconductor-metal hybrid nanoheterodimers (NHDs), leading to advanced nanoparticles architectures for applications in areas as different as photocatalysis, hydrogen production, photovoltaics, and light detection.	Hydrogen	247-255	TOR signaling pathway regulator	Homo sapiens	85-88
19580334-4	2009	In this paper, structures of three C-terminal (R36-K45) analogues of human beta-defensin-3 were studied by 1H NMR spectroscopy and extensive molecular dynamics simulations.	Hydrogen	107-109	defensin beta 103B	Homo sapiens	75-90
34684974-7	2021	Furthermore, the graphene structures with slit-shaped pores were found to be very capable of adsorbing methane and separating methane from hydrogen in a mixture at reasonable working conditions (300 K and well below 15 atm).	Hydrogen	139-147	ATM serine/threonine kinase	Homo sapiens	219-222
19603758-7	2009	With the aid of ab initio calculations at the MP2/6-31+G* level, the 3300 cm(-1) bands are assigned to the bending overtone and the hydrogen-bonded OH vibration of H2O bound to CO2- via a single O-H...O linkage.	Hydrogen	132-140	tryptase pseudogene 1	Homo sapiens	46-54
34641044-5	2021	It was found that grafting MMT nanosheets with a mixture of star-shaped and linear PMA and with PMA that is cross-linked via hydrogen bonds further decrease gas permeability.	Hydrogen	125-133	gastrin	Homo sapiens	157-160
19552431-5	2009	Extensive exploration of its structure-activity relationship resulted in a series of highly potent B(2) receptor antagonists, featuring a hydrogen bond accepting functionality, which presumably interacts with the side chain of Asn-107 of the B(2) receptor.	Hydrogen	138-146	bradykinin receptor B2	Homo sapiens	99-112
34564668-9	2021	A water molecule was hydrogen-bonded to residues Thr9 and Ser 11, as reported for the yeast Gtt2, suggesting a primary role in the reaction.	Hydrogen	21-29	glutathione transferase GTT2	Saccharomyces cerevisiae S288C	92-96
34519748-2	2021	This study proposes an effective strategy for the construction of Fe doped CoP nanosheet arrays wrapped by graphene (F0.25CP-G) on nickel foam as an efficient electrocatalyst for the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER).	Hydrogen	183-191	caspase recruitment domain family member 16	Homo sapiens	75-78
19552431-5	2009	Extensive exploration of its structure-activity relationship resulted in a series of highly potent B(2) receptor antagonists, featuring a hydrogen bond accepting functionality, which presumably interacts with the side chain of Asn-107 of the B(2) receptor.	Hydrogen	138-146	bradykinin receptor B2	Homo sapiens	242-255
19298826-0	2009	Nucleotide- and activator-dependent structural and dynamic changes of arp2/3 complex monitored by hydrogen/deuterium exchange and mass spectrometry.	Hydrogen	98-106	actin related protein 2	Homo sapiens	70-74
34612437-3	2021	In the case of OH-(H2O)26, we show that MP2 and CCSD(T) calculations predict global minima structures with the hydroxide ion occupying the interior region of a densely packed cubic cluster that is secured by ionic hydrogen bonds.	Hydrogen	214-222	tryptase pseudogene 1	Homo sapiens	40-43
34703571-7	2021	The known reduced hydride species (HFe(CO)4)- and (HFe3(CO)11)- have been observed as products by 1H/2H NMR and IR spectroscopies, as well as independent syntheses of PNP(HFe(CO)4).	Hydrogen	98-100	transferrin receptor 2	Homo sapiens	51-55
19298826-4	2009	Changes in the rate of hydrogen exchange indicate that ATP binding causes conformational rearrangements of Arp2 and Arp3 that are transmitted allosterically to the Arp complex (ARPC)1, ARPC2, ARPC4, and ARPC5 subunits.	Hydrogen	23-31	actin related protein 2	Homo sapiens	107-111
19298826-4	2009	Changes in the rate of hydrogen exchange indicate that ATP binding causes conformational rearrangements of Arp2 and Arp3 that are transmitted allosterically to the Arp complex (ARPC)1, ARPC2, ARPC4, and ARPC5 subunits.	Hydrogen	23-31	cysteine rich secretory protein 1	Homo sapiens	107-110
19298826-4	2009	Changes in the rate of hydrogen exchange indicate that ATP binding causes conformational rearrangements of Arp2 and Arp3 that are transmitted allosterically to the Arp complex (ARPC)1, ARPC2, ARPC4, and ARPC5 subunits.	Hydrogen	23-31	actin related protein 2/3 complex subunit 2	Homo sapiens	185-190
19298826-6	2009	Binding of the VCA domain of WASp to ATP-Arp2/3 further modulates the rates of hydrogen exchange in these subunits, indicating that a global conformational reorganization is occurring.	Hydrogen	79-87	WASP actin nucleation promoting factor	Homo sapiens	29-33
19298826-6	2009	Binding of the VCA domain of WASp to ATP-Arp2/3 further modulates the rates of hydrogen exchange in these subunits, indicating that a global conformational reorganization is occurring.	Hydrogen	79-87	actin related protein 2	Homo sapiens	41-45
19566094-5	2009	Spectroscopic study of photolysis solutions suggests that hydrogen production occurs through protonation of a Co(I) species to give a Co(III) hydride, which then reacts further by reduction and protolysis to give Co(II) and molecular hydrogen.	Hydrogen	58-66	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	110-115
34365467-13	2021	The association between molecular hydrogen and klotho in renal fibrosis is well known; this is the first report on the association in a unilateral ureteral obstruction model.	Hydrogen	34-42	Klotho	Rattus norvegicus	47-53
19566094-5	2009	Spectroscopic study of photolysis solutions suggests that hydrogen production occurs through protonation of a Co(I) species to give a Co(III) hydride, which then reacts further by reduction and protolysis to give Co(II) and molecular hydrogen.	Hydrogen	234-242	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	110-115
19505462-0	2009	Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?	Hydrogen	103-111	sucrase-isomaltase	Homo sapiens	19-36
34423224-5	2021	FeS is conducive to the rupture of distal aliphatic groups in the extractible solutes, which promotes the entrance of hydrogen into the aromatic nucleus (Har) and alpha positions (Halpha) of asphaltenes and beta positions (Hbeta) of preasphaltenes.	Hydrogen	118-126	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	154-157
19505462-2	2009	We propose that the cardiovascular benefits of alpha-glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H(2) in the gastrointestinal tract.	Hydrogen	176-180	sucrase-isomaltase	Homo sapiens	47-64
34244821-0	2021	Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy.	Hydrogen	0-8	PTEN induced putative kinase 1	Mus musculus	68-73
19505462-3	2009	Acarbose, which is an alpha-glucosidase inhibitor, markedly increased H(2) production, with a weaker effect on methane production.	Hydrogen	70-74	sucrase-isomaltase	Homo sapiens	22-39
34244821-11	2021	PINK1 was required for the mitigation of the cell impairment in LPS-stimulated macrophages by hydrogen treatment.	Hydrogen	94-102	PTEN induced putative kinase 1	Mus musculus	0-5
19383568-4	2009	MP2 and DFT calculations reveal that for alpha-glygly clusters, stability of N-H...O and C-H...O hydrogen bonds are enhanced significantly as a result of cooperativity effects.	Hydrogen	97-105	tryptase pseudogene 1	Homo sapiens	0-3
34244821-12	2021	PINK1 knockdown abrogated the beneficial effects of hydrogen on mitophagy in LPS-stimulated macrophages.	Hydrogen	52-60	PTEN induced putative kinase 1	Mus musculus	0-5
34244821-13	2021	Hydrogen inhibited acute lung injury in CLP mice via activation of PINK1-mediated mitophagy.	Hydrogen	0-8	PTEN induced putative kinase 1	Mus musculus	67-72
34244821-14	2021	CONCLUSION: These results suggest that PINK1-mediated mitophagy plays a key role in the protective effects of hydrogen against cell injury in LPS-induced inflammation and CLP-induced acute lung injury.	Hydrogen	110-118	PTEN induced putative kinase 1	Mus musculus	39-44
26450213-6	2015	We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to reveal conformational changes accompanying membrane binding and identify a Vps30 loop that is critical for the ability of complex II to phosphorylate giant liposomes on which complex I is inactive.	Hydrogen	8-16	beclin 1	Homo sapiens	141-146
26605136-2	2015	The crystal structure of Rhodobacter capsulatus ALAS indicates that the adenosyl moiety of succinyl-CoA is positioned in a mainly hydrophobic pocket, where the ribose group forms a putative hydrogen bond with Lys156.	Hydrogen	190-198	aminolevulinic acid synthase 2, erythroid	Mus musculus	48-52
19450588-2	2009	Hydrogen exchange rates of the imino protons were measured for various CPD-containing DNA duplexes to better understand the mechanism for CPD recognition by XPC-hHR23B.	Hydrogen	0-8	RAD23 homolog B, nucleotide excision repair protein	Homo sapiens	161-167
26314394-2	2015	The protonation states and hydration structure of RIS bound to FPPS were determined by neutron protein crystallography, which allows direct visualization of hydrogens and deuteriums.	Hydrogen	157-166	farnesyl diphosphate synthase	Homo sapiens	63-67
34225067-0	2021	A comparison of through-space population transfers from half-integer spin quadrupolar nuclei to 1H using MQ-HETCOR and MQ-SPAM-HETCOR under fast MAS.	Hydrogen	96-98	eyes shut homolog	Homo sapiens	122-126
19518886-3	2009	After thermal treatment of vapor phase grown ZnO samples in hydrogen atmosphere, most hydrogen forms shallow donors at the bond-centered site (HBC).	Hydrogen	60-68	keratin 88, pseudogene	Homo sapiens	143-146
34321467-5	2021	Under precise regulation of local coordination environments of catalytically active sites and the existence of the defects, Ru1/D-NiFe LDH delivers an ultralow overpotential of 18 mV at 10 mA cm-2 for hydrogen evolution reaction, surpassing the commercial Pt/C catalyst.	Hydrogen	201-209	Scm like with four mbt domains 1	Homo sapiens	124-127
34321467-6	2021	Density functional theory calculations reveal that Ru1/D-NiFe LDH optimizes the adsorption energies of intermediates for hydrogen evolution reaction and promotes the O-O coupling at a Ru-O active site for oxygen evolution reaction.	Hydrogen	121-129	Scm like with four mbt domains 1	Homo sapiens	51-54
26159698-3	2015	Butyrate has been shown to stimulate electroneutral sodium absorption through its regulation on sodium/hydrogen exchanger 3 (NHE3).	Hydrogen	103-111	solute carrier family 9 member A3	Homo sapiens	125-129
19518886-3	2009	After thermal treatment of vapor phase grown ZnO samples in hydrogen atmosphere, most hydrogen forms shallow donors at the bond-centered site (HBC).	Hydrogen	86-94	keratin 88, pseudogene	Homo sapiens	143-146
34247488-15	2021	Analysis of the interactions between the ligands and FRalpha shows that in order to accomplish specific binding to the active site, a combination of hydrogen bonding, pi-stacking, and van der Waals and Coulomb attraction should be feasible simultaneously for the vector molecule.	Hydrogen	149-157	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	53-60
19518886-4	2009	Subsequently, HBC migrates through the crystal and forms electrically inactive H2.	Hydrogen	79-81	keratin 88, pseudogene	Homo sapiens	14-17
19203792-9	2009	RESULTS: Leptin significantly increased system A amino acid transporter activity by 22-42% after 1h of incubation.	Hydrogen	97-99	leptin	Homo sapiens	9-15
34285302-6	2021	Our structural comparison with GroEL shows that mHsp60 contains several unique sequences that directly decrease the sidechain interactions around the beta sheet and indirectly shorten beta strands by disengaging the backbones of the flanking residues from hydrogen bonding in the beta strand conformation.	Hydrogen	256-264	heat shock protein 1 (chaperonin)	Mus musculus	48-54
26154975-1	2015	Soybean lipoxygenase-1 (SLO-1) is a paradigmatic enzyme system for studying the contribution of hydrogen tunneling to enzymatic proton-coupled electron transfer processes.	Hydrogen	96-104	linoleate 9S-lipoxygenase-4	Glycine max	8-20
26234741-0	2015	A first-principles examination of conducting monolayer 1T"-MX2 (M = Mo, W; X = S, Se, Te): promising catalysts for hydrogen evolution reaction and its enhancement by strain.	Hydrogen	115-123	MX dynamin like GTPase 2	Homo sapiens	59-62
26234741-1	2015	We investigated the application of 1T"-MX2 (M = Mo, W; X = S, Se, Te) 2D materials as hydrogen evolution reaction (HER) catalysts using density functional theory.	Hydrogen	86-94	MX dynamin like GTPase 2	Homo sapiens	39-42
19176520-0	2009	Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase.	Hydrogen	56-64	thioredoxin	Homo sapiens	24-35
26196408-1	2015	Low-temperature scanning tunneling microscopy (LT-STM) was used to move hydrogen atoms and dissociate NH molecules on a Pt(111) surface covered with an ordered array of nitrogen atoms in a (2 x 2) structure.	Hydrogen	72-80	sulfotransferase family 1A member 3	Homo sapiens	50-53
19226157-1	2009	We report here that the monodentate complexation of Me2AlCl to an ester group significantly enhances the selectivity of hydrogen transfer on acyclic radicals flanked by both an ester functionality and a stereogenic center, leading to C-2,C-3-anti products with high diastereoselectivity.	Hydrogen	120-128	complement C2	Homo sapiens	234-237
26181684-9	2015	We show that the chemicurrent, composed of hot electrons excited by the surface reaction of CO oxidation or hydrogen oxidation, correlates well with the turnover rate measured separately by gas chromatography.	Hydrogen	108-116	alcohol dehydrogenase iron containing 1	Homo sapiens	43-46
25940762-8	2015	Immunoreactivity of p-nNOS at Ser(847) was observed in interneurons of the hippocampus at 1h after SAH.	Hydrogen	90-92	nitric oxide synthase 1	Rattus norvegicus	22-26
34269678-5	2021	Multiple interaction types are responsible for A2AR oligomerization, including disulfide linkages, hydrogen bonds, electrostatic interactions, and hydrophobic interactions.	Hydrogen	99-107	adenosine A2a receptor	Homo sapiens	47-51
19109523-1	2009	NHE8 transporter is a member of the sodium/hydrogen exchanger (NHE) family.	Hydrogen	43-51	solute carrier family 9 member A8	Homo sapiens	0-4
34386323-9	2021	G201, K220, K230, A321, and D335 in kinase domain of GRK2 might form hydrogen bonds with CP-25.	Hydrogen	69-77	homeobox C6	Homo sapiens	89-94
26200797-9	2015	The 3:3 NH(imidazole)   Cl(-) hydrogen-bonds form a stepwise ladder assembly structure, which is maintained during the spin transition process.	Hydrogen	30-38	spindlin 1	Homo sapiens	119-123
34117841-0	2021	Cr-Doped CoP Nanorod Arrays as High-Performance Hydrogen Evolution Reaction Catalysts at High Current Density.	Hydrogen	48-56	caspase recruitment domain family member 16	Homo sapiens	9-12
19170039-1	2009	The epitope of horse cytochrome c against monoclonal antibody E8 was determined using amide hydrogen/deuterium (H/D) exchange combined with immobilized antibody, on-line pepsin proteolysis, liquid chromatography (LC), and mass spectrometry (MS).	Hydrogen	92-100	cytochrome c, somatic	Equus caballus	21-33
34117841-4	2021	The high performance is attributed to the Cr doping, which optimizes the hydrogen binding energy of CoP and prevents its oxidation.	Hydrogen	73-81	caspase recruitment domain family member 16	Homo sapiens	100-103
25920949-8	2015	RESULTS: Study reveals potent selective molecules that interact and form hydrogen bonds with amino acids Ser-6 and Lys-22 are common to established melatonin inhibitors for MT-III.	Hydrogen	73-81	metallothionein 3	Homo sapiens	173-179
21582271-2	2009	Inter-molecular hydrogen bonds and C-H  pi inter-actions produce R(2) (2)(10), R(4) (4)(27) and R(4) (4)(29) rings.	Hydrogen	16-24	ribonucleotide reductase regulatory subunit M2	Homo sapiens	65-69
25836764-4	2015	This early activation at 1h appeared to be independent of receptor (Lrp5/6) mediated activation as it occurred in the presence of the inhibitors sclerostin and/or Dkk1.	Hydrogen	25-27	sclerostin	Mus musculus	145-155
34126011-3	2021	Photocatalytic tests of Pp-x@g-C3N4 in water splitting unveiled much better Pp-x@g-C3N4 hydrogen evolution activities by comparison with both g-C3N4 and Pp-0.	Hydrogen	88-96	protein phosphatase 4 catalytic subunit	Homo sapiens	24-28
34126011-3	2021	Photocatalytic tests of Pp-x@g-C3N4 in water splitting unveiled much better Pp-x@g-C3N4 hydrogen evolution activities by comparison with both g-C3N4 and Pp-0.	Hydrogen	88-96	protein phosphatase 4 catalytic subunit	Homo sapiens	76-80
34126011-5	2021	Although the lengthening methylene chain in the polymers weakened the hydrogen generation ability of Pp-x@g-C3N4, the conjugated double bonds, solubilization, and dispersion of Pp-x polycationic surfactants made Pp-x@g-C3N4 superior to g-C3N4 in water splitting.	Hydrogen	70-78	protein phosphatase 4 catalytic subunit	Homo sapiens	101-105
19201867-7	2009	Of the 21 residues, 9 interact directly with 5 of the 6 CDRs (L1, L3, H1, H2, H3) of the IgE Fab predominantly by hydrogen bonding and van der Waals interactions.	Hydrogen	114-122	FA complementation group B	Homo sapiens	93-96
34375519-4	2021	Molecular docking simulations of ganolucidic acid A/D and ganoderic acid A/B predicted the strongest binding affinity via hydrogen bonding, suggesting the inhibition of HIV-1 gp120 attachment to CD4.	Hydrogen	122-130	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	175-180
25923908-5	2015	Molecular docking and molecular dynamics (MD) simulation studies showed that curcumin could be embedded into the hydrophobic pocket of MD-2 and form stable hydrogen bonding interactions with residues R90 and Y102 of MD-2.	Hydrogen	156-164	lymphocyte antigen 96	Homo sapiens	216-220
25739357-2	2015	We hypothesized that HS-induced enhanced vascular relaxation through A2AAR and epoxyeicosatrienoic acid (EETs) is dependent on peroxisome proliferator-activated receptor gamma (PPARgamma) and ATP-sensitive potassium channels (KATP channels) in A2AAR(+/+) mice, while HS-induced vascular contraction to adenosine is dependent on soluble epoxide hydrolase (sEH) that degrades EETs in A2AAR(-/-) mice.	Hydrogen	21-23	epoxide hydrolase 2, cytoplasmic	Mus musculus	328-353
25739357-2	2015	We hypothesized that HS-induced enhanced vascular relaxation through A2AAR and epoxyeicosatrienoic acid (EETs) is dependent on peroxisome proliferator-activated receptor gamma (PPARgamma) and ATP-sensitive potassium channels (KATP channels) in A2AAR(+/+) mice, while HS-induced vascular contraction to adenosine is dependent on soluble epoxide hydrolase (sEH) that degrades EETs in A2AAR(-/-) mice.	Hydrogen	21-23	epoxide hydrolase 2, cytoplasmic	Mus musculus	355-358
19133769-4	2009	With a molecular orbital calculation, the O(2)(*-) species is understood to attack the 2-position (C-2) of the imidazolium ring (i.e., BMMI(+)) to form an ion pair complex in which one oxygen atom is bounded to C-2 and the other to the hydrogen atom of -CH(3) group attached to C-2.	Hydrogen	236-244	complement C2	Homo sapiens	99-102
25111373-6	2015	The molecular docking studies revealed that the ACE inhibition of Ala-Ser-Leu is mainly attributed to forming very strong hydrogen bonds with the S1 pocket (Ala354) and the S2 pocket (Gln281 and His353).	Hydrogen	122-130	acetylcholinesterase type 2	Bombyx mori	48-51
19133769-4	2009	With a molecular orbital calculation, the O(2)(*-) species is understood to attack the 2-position (C-2) of the imidazolium ring (i.e., BMMI(+)) to form an ion pair complex in which one oxygen atom is bounded to C-2 and the other to the hydrogen atom of -CH(3) group attached to C-2.	Hydrogen	236-244	complement C2	Homo sapiens	211-214
26000658-3	2015	Here, we construct a hydrogen-terminated zigzag silicene nanoribbon heterojunction, and find that by applying a temperature difference between the source and the drain, spin-up and spin-down currents are generated and flow in opposite directions with nearly equal magnitudes, indicating that the thermal spin current dominates the carrier transport while the thermal electron current is much suppressed.	Hydrogen	21-29	spindlin 1	Homo sapiens	169-173
26000658-3	2015	Here, we construct a hydrogen-terminated zigzag silicene nanoribbon heterojunction, and find that by applying a temperature difference between the source and the drain, spin-up and spin-down currents are generated and flow in opposite directions with nearly equal magnitudes, indicating that the thermal spin current dominates the carrier transport while the thermal electron current is much suppressed.	Hydrogen	21-29	spindlin 1	Homo sapiens	181-185
26000658-3	2015	Here, we construct a hydrogen-terminated zigzag silicene nanoribbon heterojunction, and find that by applying a temperature difference between the source and the drain, spin-up and spin-down currents are generated and flow in opposite directions with nearly equal magnitudes, indicating that the thermal spin current dominates the carrier transport while the thermal electron current is much suppressed.	Hydrogen	21-29	spindlin 1	Homo sapiens	181-185
19133769-4	2009	With a molecular orbital calculation, the O(2)(*-) species is understood to attack the 2-position (C-2) of the imidazolium ring (i.e., BMMI(+)) to form an ion pair complex in which one oxygen atom is bounded to C-2 and the other to the hydrogen atom of -CH(3) group attached to C-2.	Hydrogen	236-244	complement C2	Homo sapiens	211-214
19333418-1	2009	The sign preference of hydrogen bonded aqueous ionic clusters X+/-(H(2)O)(i) (n =1-5, X = F; Cl; Br) has been investigated using the Density Functional Theory and ab initio MP2 method.	Hydrogen	23-31	tryptase pseudogene 1	Homo sapiens	173-176
25740712-0	2015	2H   1T phase transition and hydrogen evolution activity of MoS2, MoSe2, WS2 and WSe2 strongly depends on the MX2 composition.	Hydrogen	29-37	MX dynamin like GTPase 2	Homo sapiens	110-113
25880616-2	2015	Though they are lacking strong hydrogen bonds as observed in calixarenes, the two examples introduced here each adopt a vase-like conformation with all four aromatic units pointing in one direction (syn orientation).	Hydrogen	31-39	synemin	Homo sapiens	199-202
19196184-8	2009	The affinity of NKp30 and NKp44 for synthetic HS/heparin is approximately one order of magnitude higher than the affinity of NKp46.	Hydrogen	46-48	natural cytotoxicity triggering receptor 3	Homo sapiens	16-21
19115327-4	2009	In particular, a very balanced treatment of hydrogen-bonded compared to stacked complexes is achieved with MP2.5.	Hydrogen	44-52	tryptase pseudogene 1	Homo sapiens	107-110
25867524-4	2015	The elimination of the bulky t-Boc side groups resulted in the emergence of N-H   O C hydrogen bonding interactions by virtue of the lactam structures of the indigo, isoindigo and diketopyrrolopyrrole units.	Hydrogen	86-94	BOC cell adhesion associated, oncogene regulated	Homo sapiens	31-34
25735837-10	2015	Both MRP4 and BSEP inhibitor pharmacophore models were characterized by hydrophobic and hydrogen-bond acceptor features, albeit in distinct spatial arrangements.	Hydrogen	88-96	ATP binding cassette subfamily C member 4	Homo sapiens	5-9
25735837-10	2015	Both MRP4 and BSEP inhibitor pharmacophore models were characterized by hydrophobic and hydrogen-bond acceptor features, albeit in distinct spatial arrangements.	Hydrogen	88-96	ATP binding cassette subfamily B member 11	Homo sapiens	14-18
19118197-5	2009	Trp-1 of the lectin domain and the long axis of the EGF domain form an L-shaped prybar that is welded together by hydrogen bonds to the Trp-1 alpha-amino group.	Hydrogen	114-122	tRNA-Pro (anticodon AGG) 2-5	Homo sapiens	0-5
25756753-1	2015	H3 O(+) and OH(-) , formed by the self-ionization of two coordinating water molecules during the crystal growing of a host molecule [1,3,5-tris(hydroxymethyl)2,4,6-triethylbenzene (1)], could be effectively stabilized by hydrogen-bonding interactions with the preorganized hydroxy groups of three molecules of 1.	Hydrogen	221-229	H3 clustered histone 15	Homo sapiens	0-17
19118197-5	2009	Trp-1 of the lectin domain and the long axis of the EGF domain form an L-shaped prybar that is welded together by hydrogen bonds to the Trp-1 alpha-amino group.	Hydrogen	114-122	tRNA-Pro (anticodon AGG) 2-5	Homo sapiens	136-141
18834890-7	2008	Most hydrogen-bond and weaker C-H...O interactions with inhibitors were conserved in the PR2 and PR1 complexes, except for small changes in interactions with water or disordered side chains.	Hydrogen	5-13	transmembrane protein 37	Homo sapiens	97-100
25706509-6	2015	Additionally, the hydrophobic staple shields a network of water molecules, kinetically stabilizing a water chain hydrogen-bonded between the peptide and MDM2.	Hydrogen	113-121	MDM2 proto-oncogene	Homo sapiens	153-157
19636897-0	2008	1H and 15N resonance assignment of the second fibronectin type III module of the neural cell adhesion molecule.	Hydrogen	0-2	neural cell adhesion molecule 1	Homo sapiens	81-110
19636899-0	2008	1H, 13C and 15N resonance assignments for the active conformation of the small G protein RalB in complex with its effector RLIP76.	Hydrogen	0-2	RAS like proto-oncogene B	Homo sapiens	89-93
25856303-7	2015	Three-dimensional modeling placed the new mutation in a region adjacent to two previously identified disease-causing mutations, all three of which likely disrupt hydrogen bonding within the gating loop, yielding a CAPN5 with altered enzymatic activity.	Hydrogen	162-170	calpain 5	Homo sapiens	214-219
19636899-0	2008	1H, 13C and 15N resonance assignments for the active conformation of the small G protein RalB in complex with its effector RLIP76.	Hydrogen	0-2	ralA binding protein 1	Homo sapiens	123-129
19636905-0	2008	1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 29 kDa human galectin-1 protein dimer.	Hydrogen	0-2	galectin 1	Homo sapiens	89-99
17602795-6	2008	We suggest that inclusion of exon 3 in MAPT transcripts may contribute to protecting H2 carries from neurodegeneration.	Hydrogen	85-87	microtubule associated protein tau	Homo sapiens	39-43
25826316-5	2015	Hydrogen-deuterium exchange experiments identified the landscape of the Fra/HemH interaction interface and revealed Fra as a specific ferrous iron donor for the ferrochelatase HemH.	Hydrogen	0-8	ferrochelatase	Homo sapiens	161-175
18839942-2	2008	A couple of hexa-substituted benzene molecules were encapsulated inside the capsule in both solution and the solid state, as was evidenced by 1H NMR spectroscopy and single-crystal X-ray analysis.	Hydrogen	142-144	hexosaminidase subunit alpha	Homo sapiens	12-16
33429518-7	2015	For IL-10 secretion, hydrogen bonding was very negatively correlated with pro-inflammatory cells, whereas it was positively correlated with pro-angiogenic cells.	Hydrogen	21-29	interleukin 10	Homo sapiens	4-9
18782556-4	2008	In AKR1C1, the inhibitor formed a 10-fold stronger binding interaction with the catalytic residue (Tyr55), non-conserved hydrogen bonding interaction with His222, and additional van der Waals contacts with the non-conserved C-terminal residues Leu306, Leu308 and Phe311 that contribute to the inhibitor"s selectivity advantage for AKR1C1 over ALR1.	Hydrogen	121-129	aldo-keto reductase family 1 member C1	Homo sapiens	3-9
25654263-8	2015	Amide hydrogen-deuterium exchange (HDXMS) experiments showed that both ASB9(1-252) and ASB9(35-252) protected the same region of CK, residues 182-203, which forms one side of the active site.	Hydrogen	6-14	ankyrin repeat and SOCS box containing 9	Homo sapiens	71-75
25654263-8	2015	Amide hydrogen-deuterium exchange (HDXMS) experiments showed that both ASB9(1-252) and ASB9(35-252) protected the same region of CK, residues 182-203, which forms one side of the active site.	Hydrogen	6-14	ankyrin repeat and SOCS box containing 9	Homo sapiens	87-91
25490569-7	2015	The hydrogen uptake of Pd/AC-ox1 at RT and 8 MPa with an oxygen content of 8.94 wt.% was 0.37 wt.%, which was 48% greater than that of Pd-free AC-ox (0.25 wt.%).	Hydrogen	4-12	acyl-CoA oxidase 1	Homo sapiens	26-32
25639210-2	2015	Out of a set of protic ionic liquids (PILs), including trialkylammonium cations and methylsulfonate and triflate anions we could detect the transfer from hydrogen-bonding to dispersion-dominated interaction between cation and anion in the PIL [(C6 H13 )3 NH][CF3 SO3 ].	Hydrogen	154-162	serpin family A member 2 (gene/pseudogene)	Homo sapiens	38-41
25708299-4	2015	In this study, we discovered that mutations in the structurally buried D38 residue of PP2Calpha (PPM1A) redefined the water-mediated hydrogen network in the active site and selectively disrupted M2 metal ion binding.	Hydrogen	133-141	protein phosphatase, Mg2+/Mn2+ dependent 1A	Homo sapiens	86-95
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Hydrogen	271-279	intercellular adhesion molecule 2	Homo sapiens	444-450
25708299-4	2015	In this study, we discovered that mutations in the structurally buried D38 residue of PP2Calpha (PPM1A) redefined the water-mediated hydrogen network in the active site and selectively disrupted M2 metal ion binding.	Hydrogen	133-141	protein phosphatase, Mg2+/Mn2+ dependent 1A	Homo sapiens	97-102
26261966-1	2015	Using density functional theory, a possible pathway of soot surface growth is studied in the low-temperature, postflame region in which spin-triplet polycyclic aromatic hydrocarbon (PAH) molecules with a small singlet-triplet energy gap react with unsaturated aliphatics such as acetylene via the carbon-addition-hydrogen-migration (CAHM) reaction.	Hydrogen	313-321	spindlin 1	Homo sapiens	136-140
18940604-5	2008	The Rab27B/Slac2-a complex exhibits several intermolecular hydrogen bonds that were not observed in the previously reported Rab3A/rabphilin complex.	Hydrogen	59-67	RAB3A, member RAS oncogene family	Homo sapiens	124-129
27182431-5	2015	In particular, we show that prolonged UV-irradiation of cytidine may lead to H-C1" hydrogen atom abstraction by the carbonyl oxygen atom of cytosine.	Hydrogen	83-91	CYCS pseudogene 39	Homo sapiens	77-81
18790640-3	2008	Installing a hydroxyl group on the benzene ring of the core has the potential to form a key hydrogen bond interaction to the hinge region of the binding pocket and thus resulted in the most potent inhibitor, 19, with K(i) values at 2.5 and 43.5 nM against Pim-1 and Pim-2, respectively.	Hydrogen	92-100	Pim-2 proto-oncogene, serine/threonine kinase	Homo sapiens	266-271
25325975-1	2015	Several classes of heparan sulfate proteoglycan (HSPG) core proteins and all HS biosynthetic/modifying enzymes are evolutionarily conserved from human to Drosophila melanogaster.	Hydrogen	49-51	CD44 molecule (Indian blood group)	Homo sapiens	19-47
34691690-4	2021	More interestingly, room-temperature ferromagnetism, graphene-CaCl heterojunction, coexistence of piezoelectricity-like property and metallicity, as well as the distinct hydrogen storage and release capability of the CaCl crystals in rGO membranes are experimentally demonstrated.	Hydrogen	170-178	solute carrier family 25 member 29	Homo sapiens	217-221
34691690-7	2021	The findings highlight the realistic potential applications of such abnormal CaCl material with unusual electronic properties in designing novel transistors and magnetic devices, hydrogen storage, catalyzers, high-performance conducting electrodes and sensors, with a size down to atomic scale.	Hydrogen	179-187	solute carrier family 25 member 29	Homo sapiens	77-81
18767838-4	2008	Properties of B(+)-H2 and the related Li(+)-H2, Na(+)-H2, and Al(+)-H2 complexes are explored through ab initio calculations at the MP2/aug-cc-pVTZ level.	Hydrogen	15-21	tryptase pseudogene 1	Homo sapiens	132-135
35569167-0	2022	Stomatal closure induced by hydrogen-rich water is dependent on GPA1 in Arabidopsis thaliana.	Hydrogen	28-36	G protein alpha subunit 1	Arabidopsis thaliana	64-68
26060595-3	2015	Slow nicotine metabolizers (i.e., CYP2A6(*)1H, CYP2A6(*)4A, CYP2A6(*)9, and CYP2A6(*)12A) are associated with underrated nicotine metabolizing activity (50%-75%), linking them to low scores for nicotine dependence (0-4) on the FTND scale.	Hydrogen	43-45	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	34-40
18784770-1	2008	Two-photon laser-induced fluorescence (TP-LIF) line imaging of atomic hydrogen was investigated in a series of premixed CH4/O2/N2, H2/O2, and H2/O2/N2 flames using excitation with either picosecond or nanosecond pulsed lasers operating at 205 nm.	Hydrogen	70-78	LIF interleukin 6 family cytokine	Homo sapiens	42-45
25399145-0	2014	Fully quantal calculation of H2 translation-rotation states in the (p-H2)2@5(12)6(4) clathrate hydrate inclusion compound.	Hydrogen	29-31	polyhomeotic homolog 2	Homo sapiens	68-72
35462234-7	2022	These results imply that cannabinoids could affect the activity of the TET1 protein not only due to their affinity for Fe(II) but also due to other types of interactions (e.g., hydrophobic interactions and hydrogen bonding).	Hydrogen	206-214	tet methylcytosine dioxygenase 1	Homo sapiens	71-75
18665299-1	2008	A reconstituted myoglobin with a synthetic cofactor having anionic binding sites effectively works as a photocatalyst for hydrogen generation in the presence of monomethylated bipyridinium.	Hydrogen	122-130	myoglobin	Homo sapiens	16-25
35288361-9	2022	ChEBML196567 and ZINC000013942794 are the most recommended, because they formed strong binding energies and stable hydrogen bonds with TEAD2 and have good drugbility and high human oral absorption.	Hydrogen	115-123	TEA domain transcription factor 2	Homo sapiens	135-140
35437533-6	2022	Furthermore, our calculated hydrogen binding energy (HBE) demonstrates that Pt/MnN, Pt/TiN, Pt/FeN, Pt/VN, Pt/HfN, Pd/FeN, Pd/TaN, Pd/NbN, Pd/TiN, Pd/HfN, Pd/MnN, Pd/ScN, Pd/VN, and Pd/ZrN are promising candidates for the HER with a low value of limiting potential (UL) similar to that calculated on Pt(111).	Hydrogen	28-36	nibrin	Homo sapiens	134-137
25400523-2	2014	The conventional mechanism for the dealkylation of N1-methyl adenine (1-meA) catalyzed by AlkB after the formation of FeIV-oxo is comprised by a reorientation of the oxo moiety, hydrogen abstraction, OH rebound from the Fe atom to the methyl adduct, and the dissociation of the resulting methoxide to obtain the repaired adenine base and formaldehyde.	Hydrogen	178-186	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	90-94
25430288-0	2014	Determination of hydrogen/deuterium ratio with neutron measurements on MAST.	Hydrogen	17-25	SPG21 abhydrolase domain containing, maspardin	Homo sapiens	71-75
25266066-0	2014	Enhanced electrocatalytic activity of MoS(x) on TCNQ-treated electrode for hydrogen evolution reaction.	Hydrogen	75-83	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	38-41
18646861-4	2008	Interaction of the urea receptor with anions (F (-), AcO (-), H 2PO 4 (-)) via hydrogen bonding or urea NH deprotonation resulted in significant fluorescence quenching of the 1,8-naphthalimide chromophore in an appropriately chosen model compound (ca.	Hydrogen	79-87	kallikrein related peptidase 15	Homo sapiens	53-56
25337796-11	2014	Clearly there are processes of dynamics and hydrogen bond network propagation in ASP1 in response to pH stimuli.	Hydrogen	44-52	beta-secretase 2	Homo sapiens	81-85
24979063-5	2014	Analysis of the water adsorption geometry and energetics shows that the relative stability of water adsorption on SnO2(110) is governed largely by the strength of the chemisorption and hydrogen bonds at the surface of the adsorbate-substrate system.	Hydrogen	185-193	strawberry notch homolog 2	Homo sapiens	114-117
35606529-1	2022	BACKGROUND: Resorption of magnesium-based alloy bioabsorbable screws produces hydrogen gas, which can be mistaken as a sign of infection and may affect the physis or fixed bone fragment.	Hydrogen	78-86	gastrin	Homo sapiens	87-90
35122975-17	2022	According to molecular docking analysis, the formed hydrogen bonds between quercetin and Ala195, Gln308, Asn369 and Lys372 residues of TERT also indicated the indispensable role of TERT in improving wound healing capacity.	Hydrogen	52-60	telomerase reverse transcriptase	Mus musculus	135-139
25070104-7	2014	We propose, supported by simulated models of PER-2 in combination with different beta-lactams, the presence of a hydrogen-bond network connecting Ser70-Gln69-water-Thr237-Arg220 that might be important for the proper activity and inhibition of the enzyme.	Hydrogen	113-121	period circadian regulator 2	Homo sapiens	45-50
18412546-6	2008	A model of the N-terminal five amino acids from the D1 polypeptide bound in the active site of AtPDF1B suggests an influence of Tyr(178) as a structural determinant for polypeptide substrate specificity through hydrogen bonding with Thr(2) in the D1 sequence.	Hydrogen	211-219	peptide deformylase 1B	Arabidopsis thaliana	95-102
24234349-3	2014	Here, we report the backbone 1H, 13C and 15N assignments for the 47 kDa dNT-1 dimer, which will be used for structural characterisation of dNT-1 complexes with small molecule inhibitors obtained through modification of pyrimidine nucleotide scaffolds or optimisation of successful binders obtained from the screening of fragment libraries.	Hydrogen	29-31	Neurotrophin 1	Drosophila melanogaster	72-77
24234349-3	2014	Here, we report the backbone 1H, 13C and 15N assignments for the 47 kDa dNT-1 dimer, which will be used for structural characterisation of dNT-1 complexes with small molecule inhibitors obtained through modification of pyrimidine nucleotide scaffolds or optimisation of successful binders obtained from the screening of fragment libraries.	Hydrogen	29-31	Neurotrophin 1	Drosophila melanogaster	139-144
25048293-1	2014	Hydride complexes Mo,W(CO)(NO)H(mer-etp(i)p) (iPr2PCH2CH2)2PPh=etp(i)p) (2 a,b(syn), syn and anti of NO and Ph(etp(i)p) orientions) were prepared and probed in imine hydrogenations together with co-catalytic [H(Et2O)2][B(C6F5)4] (140  C, 60 bar H2).	Hydrogen	52-54	synemin	Homo sapiens	79-82
35122975-17	2022	According to molecular docking analysis, the formed hydrogen bonds between quercetin and Ala195, Gln308, Asn369 and Lys372 residues of TERT also indicated the indispensable role of TERT in improving wound healing capacity.	Hydrogen	52-60	telomerase reverse transcriptase	Mus musculus	181-185
25048293-1	2014	Hydride complexes Mo,W(CO)(NO)H(mer-etp(i)p) (iPr2PCH2CH2)2PPh=etp(i)p) (2 a,b(syn), syn and anti of NO and Ph(etp(i)p) orientions) were prepared and probed in imine hydrogenations together with co-catalytic [H(Et2O)2][B(C6F5)4] (140  C, 60 bar H2).	Hydrogen	52-54	synemin	Homo sapiens	85-88
18522944-8	2008	However, structured strands without hRPA displayed very slow spontaneous annealing because of stable intramolecular hydrogen bonding.	Hydrogen	116-124	replication protein A1	Homo sapiens	36-40
25121557-7	2014	Hydrogen administration attenuated proinflammatory changes during EVLP through upregulation of the heme oxygenase-1.	Hydrogen	0-8	heme oxygenase 1	Rattus norvegicus	99-115
35507832-5	2022	Thus, CoP/CNTHPs can catalyze the hydrogen and oxygen evolution reactions effectively with overpotentials of 147 and 238 mV at 10 mA cm-2.	Hydrogen	34-42	caspase recruitment domain family member 16	Homo sapiens	6-9
35091149-1	2022	CoP is one of the most promising catalysts for catalyzing hydrogen evolution reaction.	Hydrogen	58-66	caspase recruitment domain family member 16	Homo sapiens	0-3
18558667-3	2008	The difference, DeltalogP, between logP oct and logP hxd is a measure of the hydrogen bonding potential of a molecule and is identified as a target for predictive modeling.	Hydrogen	77-85	plexin A2	Homo sapiens	40-43
35626976-5	2022	Molecular docking indicated that the above four oat-derived peptides were predicted to form hydrogen bonds, attractive charge, and hydrophobic interactions with the residues of the active site of DPP-IV.	Hydrogen	92-100	dipeptidyl peptidase 4	Homo sapiens	196-202
18485927-5	2008	This close resemblance is due to the core structure built by same hydrogen bond formations between and within the backbone chains of alpha1 and beta1/2/5 secondary structure elements and by nearly the same hydrophobic interactions formed between the nonpolar amino acids of their secondary structures.	Hydrogen	66-74	hemoglobin, beta adult major chain	Mus musculus	144-151
35578731-0	2022	Hydrogen Recovery from Coke Oven Gas.	Hydrogen	0-8	gastrin	Homo sapiens	33-36
35578731-3	2022	In this sense, the hydrogen content of coke oven gas (COG) has positioned it as a promising source toward a hydrogen-based economy which could lead to economic and environmental benefits in the iron and steel industry.	Hydrogen	19-27	gastrin	Homo sapiens	49-52
35578731-3	2022	In this sense, the hydrogen content of coke oven gas (COG) has positioned it as a promising source toward a hydrogen-based economy which could lead to economic and environmental benefits in the iron and steel industry.	Hydrogen	108-116	gastrin	Homo sapiens	49-52
35578731-6	2022	Different routes have been explored for the recovery of hydrogen from COG so far: i) separation/purification processes with pressure swing adsorption or membrane technology, ii) conversion routes that provide additional hydrogen from the chemical transformation of the methane contained in COG, and iii) direct use of COG as fuel for internal combustion engines or gas turbines with the aim of power generation.	Hydrogen	56-64	gastrin	Homo sapiens	365-368
18485927-6	2008	The side chain NetaH of Lys27 on the alpha1 helix was crucial to the stabilization of the spatial orientations of beta3 and beta4 strands, possible binding region with Rpn 10 subunit, through three hydrogen bonds.	Hydrogen	198-206	basic helix-loop-helix family, member e22	Mus musculus	114-129
18485927-9	2008	However, a large fluctuation of beta4 strand with respect to beta5 strand was induced in the R42P mutant, because of the impossibility of forming paired hydrogen bonds of Pro for Arg42 in wild Uld.	Hydrogen	153-161	basic helix-loop-helix family, member e23	Mus musculus	32-37
18515351-0	2008	Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs.	Hydrogen	22-30	adenosine deaminase RNA specific	Homo sapiens	75-79
35352424-6	2022	Meanwhile, through in/ex-situ tests, the formation of ZnO layer on the metallic Zn surface inhibits the hydrogen evolution reactions (1.8 mmol h-1 cm-2 ) and passivation during cycling.	Hydrogen	104-112	H1.5 linker histone, cluster member	Homo sapiens	143-151
35341807-10	2022	The molecular docking analysis suggested that PBD-2 interacted with porcine SLC25A4 mainly through strong hydrogen binding, with the predicted binding affinity being -13.23 kcal/mol.	Hydrogen	106-114	solute carrier family 25 member 4	Homo sapiens	76-83
18601373-11	2008	In the PA-D PES, the hydrogen-water pair potential is described by the ab initio 5D PES of the isolated H(2)-H(2)O dimer.	Hydrogen	21-29	peptidyl arginine deiminase 4	Homo sapiens	7-11
18387359-3	2008	Functional in vitro experiments revealed that the P2Y(6) agonist UDPbetaS dose-dependently enhanced insulin and glucagon release during short-term incubation (1h), while P2Y(6) activation during a longer period (24h), selectively increased insulin release, especially at high glucose levels.	Hydrogen	159-161	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	50-56
18508159-12	2008	The increase in CCl(4) degradation rate, as the FeS films age, suggests that the process of hydrogen cracking increases the surface area available for charge transfer.	Hydrogen	92-100	C-C motif chemokine ligand 4	Homo sapiens	16-22
18493652-2	2008	We synthesized palmitic acid with carbons C-3 through C-16 perdeuterated, C-1 and C-2 with 13C atoms and hydrogens at C-2.	Hydrogen	105-114	complement C2	Homo sapiens	118-121
18464991-0	2008	Scope and limitations of the SCS-MP2 method for stacking and hydrogen bonding interactions.	Hydrogen	61-69	tryptase pseudogene 1	Homo sapiens	33-36
18330603-3	2008	B3LYP method outperforms among the different DFT methods for the computed hydrogen bond distances and found closer to the value obtained by correlated MP2 level, whereas MPW1PW91 and PBE methods shows very similar values but approximately 0.03 A less, compared to B3LYP method.	Hydrogen	74-82	tryptase pseudogene 1	Homo sapiens	151-154
18243322-7	2008	By using engineered affinity enhanced TCRs to these ligands, which have extended off-rates of approximately 1h compared to seconds for the wildtype TCRs, we have examined pMHCI/CD8 binding before and during TCR-engagement.	Hydrogen	108-110	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	38-41
18370410-3	2008	Our kinetic and spectroscopic data for S167A indicate that this residue is not essential for O 2 or substrate binding, and we propose that hydrogen bond stabilization of the catalytic ferrous-oxy complex involves active site water molecules in IDO.	Hydrogen	139-147	indoleamine 2,3-dioxygenase 1	Homo sapiens	244-247
18433185-0	2008	Cooperativity between two types of hydrogen bond in H(3)C-HCN-HCN and H(3)C-HNC-HNC complexes.	Hydrogen	35-43	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	58-61
18433185-0	2008	Cooperativity between two types of hydrogen bond in H(3)C-HCN-HCN and H(3)C-HNC-HNC complexes.	Hydrogen	35-43	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	62-65
18331844-4	2008	In the catalytic mechanism thioredoxin fold proteins bind to target proteins through conserved backbone-backbone hydrogen bonds and induce conformational changes of the target disulfide followed by nucleophilic attack by the N-terminally located low pK(a) Cys residue.	Hydrogen	113-121	thioredoxin	Homo sapiens	27-38
25044065-2	2014	The C F   H O interactions between suitably fluorinated nucleophiles and the hydrogen-bond network at the phase boundary of oil droplets enable the formation of a unique microstructure to facilitate on water catalyst-free reactions, which are difficult to realize using nonfluorinated substrates.	Hydrogen	77-85	complement factor H	Homo sapiens	4-11
25337236-5	2014	RESULT: alpha-Klotho protein concentration of control group 1h, 10h and 20 h was 757.71 +- 333.93 pg/ml, 687.38 +- 342.79 pg/ml and 912.90 +- 337.8 pg/ml, respectively.	Hydrogen	60-62	klotho	Mus musculus	14-20
18234222-0	2008	The role of multiple hydrogen-bonding groups in specific alcohol binding sites in proteins: insights from structural studies of LUSH.	Hydrogen	21-29	lush	Drosophila melanogaster	128-132
25049396-4	2014	We report the use of NMR-detected hydrogen-deuterium exchange of quenched cell lysates to measure individual opening free energies of the 56-aa B1 domain of protein G (GB1) in living Escherichia coli cells without adding destabilizing cosolutes or heat.	Hydrogen	34-42	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	168-171
24937348-9	2014	Moreover, hydrogen-rich saline treatment dose dependently ameliorated brain injury after cardiac arrest/resuscitation, which was characterized by the increase of survival neurons in hippocampus CA1, reduction of brain edema in cortex and hippocampus, preservation of blood-brain barrier integrity, as well as the decrease of serum S100beta and neuron-specific enolase.	Hydrogen	10-18	S100 calcium binding protein B	Rattus norvegicus	331-339
18064577-2	2008	The mass-analyzed ion kinetic energy (MIKE) spectrum reveals that the adduct ions [NC--CH(2)--NH(2), Ni(+)] spontaneously decompose by loosing HCN, H(2), and H(2)CNH, the loss of hydrogen cyanide being clearly dominant.	Hydrogen	88-92	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	143-146
17959711-8	2008	The docked modeling revealed that Lys531 plays a key role in forming hydrogen bonds between Rg(3) and hKv1.4 channels.	Hydrogen	69-77	potassium voltage-gated channel subfamily A member 4	Homo sapiens	102-108
24880994-5	2014	The docking results also indicated that the BLG-flavonoid complexes are stabilized through hydrophobic interactions, hydrogen bond interactions and pi-pi stacking interactions.	Hydrogen	117-125	beta-lactoglobulin	Bos taurus	44-47
24811178-0	2014	Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.	Hydrogen	53-61	lipin 2	Homo sapiens	0-7
24811178-5	2014	We provide evidence that lipin 2, like lipin 1, binds PA via the electrostatic hydrogen bond switch mechanism but has a lower rate of catalysis.	Hydrogen	79-87	lipin 2	Homo sapiens	25-32
24874300-5	2014	Specifically, the synergistic effect of temperature and pH was observed, and the hydrogen bonding between PDEA and PMAA components in the copolymer played a key role for this.	Hydrogen	81-89	phosphodiesterase 6A	Homo sapiens	106-110
35603647-0	2022	(Hydrogen alleviates collagen-induced arthritis (CIA) in mice by inhibiting IL-22 levels).	Hydrogen	1-9	interleukin 22	Mus musculus	76-81
35629327-5	2022	Based on interaction mapping, explicit 100 ns molecular dynamics simulation, and end-point binding free energy calculations, the selected natural compounds were marked for substantial stability with PD-L1 via intermolecular interactions (hydrogen and hydrophobic) with essential residues in comparison to the JQT inhibitor.	Hydrogen	238-246	CD274 molecule	Homo sapiens	199-204
35572753-7	2022	Hence, some of the steric hindrance and lack of hydrogen bond capacity previously observed in the (MSA)2(base)1-2 clusters is diminished in the corresponding (SA)1(MSA)1(base)1-2 clusters.	Hydrogen	48-56	coenzyme Q2, polyprenyltransferase	Homo sapiens	158-169
35591301-2	2022	A conventional method utilizing inductively coupled plasma with fluorocarbon gas leads the hydrogen-terminated diamond to transfer to a partially fluorine-terminated diamond (C-F diamond); an unexpected fluorohydrocarbon film is formed on the surface of the diamond.	Hydrogen	91-99	gastrin	Homo sapiens	77-80
35419789-6	2022	When the threshold of the FPG-1 + OGTT 1h + 2h-1 level in the first pregnancy was > 23.6 mmol/L, the specificity for predicting GDMR was 0.85, the sensitivity was 0.45, and the area under the receiver operating characteristic curve (ROC-AUC) was 0.70, indicating a 70% probability of predicting GDMR in the next pregnancy.	Hydrogen	39-41	nei like DNA glycosylase 1	Homo sapiens	26-31
35419789-7	2022	Logistic regression analysis showed that patients with a combined abnormal FPG-1 + OGTT 1h + 2 h-1 level had a 10-fold increased risk for GDMR in subsequent pregnancies than patients with normal indicators (OR: 10.542, 95% CI: 3.097-35.881; p < 0.0001).	Hydrogen	88-90	nei like DNA glycosylase 1	Homo sapiens	75-80
35359247-7	2022	Here, we report the 1H, 15N and 13C backbone chemical shift assignments of the acidic domain of MDMX and show that it exhibits hallmarks of intrinsic disorder and localized variation in inferred secondary structure propensity.	Hydrogen	20-22	MDM4 regulator of p53	Homo sapiens	96-100
35366775-9	2022	Most importantly, the molecular docking with dysregulated Wnt signaling proteins results shows peptide AGAP and coronaridine had maximum hydrogen bonds to beta-catenin and GSK3beta with a better binding affinity.	Hydrogen	137-145	catenin beta 1	Homo sapiens	155-167
35038671-0	2022	1H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults.	Hydrogen	0-2	microtubule associated protein tau	Homo sapiens	84-87
35038671-1	2022	Proton magnetic resonance spectroscopy (1H MRS) may provide information on pathophysiological changes associated with tau deposition in cognitively unimpaired older adults.	Hydrogen	40-42	microtubule associated protein tau	Homo sapiens	118-121
35038671-2	2022	In this study, the associations of posterior cingulate gyrus tau and amyloid beta (Abeta) deposition on PET with 1H MRS metabolite ratios acquired from bilateral posterior cingulate gyri were investigated in cognitively unimpaired older adults.	Hydrogen	113-115	microtubule associated protein tau	Homo sapiens	61-64
35424845-4	2022	The molecular structures of AR-1 and AR-2 were characterized by Fourier transform infrared (FT-IR) and 1H nuclear magnetic resonance (1H-NMR).	Hydrogen	103-105	transcription factor 20	Homo sapiens	28-32
35424845-4	2022	The molecular structures of AR-1 and AR-2 were characterized by Fourier transform infrared (FT-IR) and 1H nuclear magnetic resonance (1H-NMR).	Hydrogen	134-136	transcription factor 20	Homo sapiens	28-32
35329763-2	2022	Millimeter-sized, bead-type, bio-based lignin/chitosan (Lig/CS) adsorbent was designed for the removal of Congo red (CR), based on the electrostatic attraction, pi-pi stacking, and hydrogen bonding, which were synthesized through the emulsification of the chitosan/lignin mixture followed by chemical cross-linking.	Hydrogen	181-189	ubiquitin conjugating enzyme E2 K	Homo sapiens	56-59
35359596-6	2022	The S93 residue, which is located at the first Greek-key motif of betaB1-crystallin, is highly conserved, and its substitution to Arginine severely impaired hydrogen bonds and structural conformation, which were evaluated via Molecular Dynamic Simulation.	Hydrogen	157-165	crystallin beta B1	Homo sapiens	66-83
35335478-0	2022	Fluorophenol-Containing Hydrogen-Bond Acidic Polysiloxane for Gas Sensing-Synthesis and Characterization.	Hydrogen	24-32	gastrin	Homo sapiens	62-65
35199803-2	2022	This work presents a solution- and solid-state investigation of the effect of O-alkylation proximity on the hydrogen bonding (H-bonding) capabilities of alkoxy-CPTs, based on comparing an imidazolium alkoxy CPT with strong cation-pi, pi+ and positive charge-assisted hydrogen bonding (+CAHB) capabilities (PIMa), with two isothiouronium alkoxy CPTs with two-point +CAHB capabilities (PT1 & PT2), which have short and long alkoxy side chains, respectively.	Hydrogen	108-116	zinc finger protein 77	Homo sapiens	384-387
35072350-1	2022	Functionalized porous materials could play a key role in improving the efficiency of gas separation processes as required by applications such as carbon capture and storage (CCS) and across the hydrogen value chain.	Hydrogen	194-202	gastrin	Homo sapiens	85-88
35072350-4	2022	As a proof of function, the performance of three silica ionogels to separate an equimolar (hydrogen + carbon dioxide) gas mixture is determined by both accurate gravimetric sorption measurements and Raman spectroscopy, with the observed consistency establishing the latter as a novel measurement technique for the determination of adsorption capacity.	Hydrogen	91-99	gastrin	Homo sapiens	118-121
35268729-2	2022	In the presence of single impure gas, SO2 yielded the most inhibitions on CO2 adsorption, while the influence of water only occurred at low pressure limit (0.1 bar), where a one-dimensional chain of hydrogen-bonded molecules was formed.	Hydrogen	199-207	gastrin	Homo sapiens	33-36
35197056-6	2022	RESULTS: 1H MRS reliably quantified changes in cerebral metabolites, including glutamate/glutamine, lactate, and N-acetyl aspartate in a neuronal Pank1 and Pank2 double-knockout (SynCre+ Pank1,2 dKO) mouse model of brain CoA deficiency.	Hydrogen	9-11	pantothenate kinase 2	Mus musculus	156-161
35113094-2	2022	(Au2(mu-PAnP)(SPh)2) exists as a monomer in its crystals but (Au2(mu-PAnP)(SPhCO2H)2) polymerizes into zig-zag chains via intermolecular hydrogen bonding.	Hydrogen	137-145	PILR alpha associated neural protein	Homo sapiens	69-73
35038459-7	2022	To achieve this, PDSA was enzymatically synthesized using lipase B from Candida antartica (CAL-B), chemically modified with side chains having free primary amine (NH2) groups that can be acyl acceptor substrate of TG16, thoroughly characterized by 1H NMR spectroscopy, and then applied for the TG16-mediated conjugation reaction with rHuEPO.	Hydrogen	248-250	calbindin 1	Homo sapiens	91-96
35209128-3	2022	We investigated the possible structural modifications induced by the LHON mutation and found that its amino acid replacement would disrupt a possible hydrogen bond between native R340 and Q139 in ND4, thereby destabilizing rotenone binding.	Hydrogen	150-158	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	196-199
35170060-5	2022	Fluorescence analysis revealed that GUB quenched the fluorescence of alpha-glucosidase statically, the formation of GUB-alpha-glucosidase complex was a spontaneous and exothermic process, van der Waals forces, hydrogen bonding, and hydrophobic interaction were the predominant driving forces, only one single-binding site on alpha-glucosidase was involved in the binding process.	Hydrogen	210-218	sucrase-isomaltase	Homo sapiens	69-86
24820546-2	2014	We consider two variants of the polyalcohols: the all-syn and all-anti tetrol, which because of their different stereochemistry of the hydroxyl groups form a linear hydrogen-bonded chain that is stable for tens of picoseconds or a system where hydrogen bonds are formed and broken on a picosecond timescale, respectively.	Hydrogen	165-173	synemin	Homo sapiens	54-57
24820546-2	2014	We consider two variants of the polyalcohols: the all-syn and all-anti tetrol, which because of their different stereochemistry of the hydroxyl groups form a linear hydrogen-bonded chain that is stable for tens of picoseconds or a system where hydrogen bonds are formed and broken on a picosecond timescale, respectively.	Hydrogen	244-252	synemin	Homo sapiens	54-57
24820546-4	2014	Furthermore, we show that the stronger hydrogen bonding for the all-syn variant leads to faster fluctuations of the site frequencies than for the all-anti one, which is reflected in the higher degree of homogeneous broadening in the 2D spectra.	Hydrogen	39-47	synemin	Homo sapiens	68-71
24638848-0	2014	Electrochemically fabricated polypyrrole and MoS(x) copolymer films as a highly active hydrogen evolution electrocatalyst.	Hydrogen	87-95	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	45-48
24825186-6	2014	In addition to the original T and M1 phases, we find two orthorhombic phases, O1 and O2, which are stabilized at higher hydrogen content.	Hydrogen	120-128	immunoglobulin kappa variable 2D-40	Homo sapiens	78-87
35170060-5	2022	Fluorescence analysis revealed that GUB quenched the fluorescence of alpha-glucosidase statically, the formation of GUB-alpha-glucosidase complex was a spontaneous and exothermic process, van der Waals forces, hydrogen bonding, and hydrophobic interaction were the predominant driving forces, only one single-binding site on alpha-glucosidase was involved in the binding process.	Hydrogen	210-218	sucrase-isomaltase	Homo sapiens	120-137
35170060-6	2022	GUB inserted into the hydrophobic pocket of alpha-glucosidase with 11 hydrogen bonds and two pi-pi stacking formed.	Hydrogen	70-78	sucrase-isomaltase	Homo sapiens	44-61
18234505-6	2008	Two emission species in the both ETF may be hydrogen-bonding isomers, because isoalloxazine ring of FAD contains four hydrogen acceptors and one donor.	Hydrogen	44-52	TEA domain transcription factor 2	Homo sapiens	33-36
35104129-3	2022	Therefore, decreasing the recombination rate and increasing the migration rate of photogenerated carriers are essential to drive the development and application of CdS in hydrogen production.	Hydrogen	171-179	CDP-diacylglycerol synthase 1	Homo sapiens	164-167
35104129-8	2022	The photocatalytic hydrogen evolution rate of Pt-CdS is considerably improved after constructing the 3DOM structure.	Hydrogen	19-27	CDP-diacylglycerol synthase 1	Homo sapiens	49-52
24673410-11	2014	In conclusion, H2 S donors protected BBB integrity following experimental stroke possibly by acting through NF-kappaB inhibition to suppress neuroinflammation induction of MMP9 and NOX4-derived free radicals.	Hydrogen	15-17	matrix metallopeptidase 9	Homo sapiens	172-176
24599998-8	2014	Hydrogen-deuterium exchange analyses of unassembled Gag compared that of assembled VLPs showed strong protection at the SPA region, consistent with a higher-order structure.	Hydrogen	0-8	surfactant protein A2	Homo sapiens	120-123
18205381-2	2008	First, a simple, scalable method for their syntheses via the use of PPh3/I2/HOBt has been developed and has been mechanistically investigated by 31P(1H) NMR.	Hydrogen	149-151	protein phosphatase 4 catalytic subunit	Homo sapiens	68-72
18205361-3	2008	In the presence of excess TEMPO, [Rh(II)(tmp)] is regenerated from [Rh(III)(tmp)H] with formation of 2,2,6,6-tetramethyl-piperidine-1-ol (TEMPOH) (4) via a subsequent hydrogen atom abstraction pathway.	Hydrogen	167-175	Rh blood group D antigen	Homo sapiens	34-40
24591271-0	2014	Patterns of structural dynamics in RACK1 protein retained throughout evolution: a hydrogen-deuterium exchange study of three orthologs.	Hydrogen	82-90	receptor for activated C kinase 1	Homo sapiens	35-40
18201101-1	2008	The change in structure of bovine alpha-lactalbumin in environments of decreasing pH from pH 7 to pH 3 was followed using high-resolution NMR and hydrogen exchange studies.	Hydrogen	146-154	lactalbumin alpha	Bos taurus	34-51
24880349-0	2014	Spin-polarized hydrogen Rydberg time-of-flight: experimental measurement of the velocity-dependent H atom spin-polarization.	Hydrogen	15-23	spindlin 1	Homo sapiens	0-4
24880349-0	2014	Spin-polarized hydrogen Rydberg time-of-flight: experimental measurement of the velocity-dependent H atom spin-polarization.	Hydrogen	15-23	spindlin 1	Homo sapiens	106-110
24880349-1	2014	We have developed a new experimental method allowing direct detection of the velocity dependent spin-polarization of hydrogen atoms produced in photodissociation.	Hydrogen	117-125	spindlin 1	Homo sapiens	96-100
35080392-3	2022	However, the stability issues, e.g., the dissolution in Pd-M and the hydrogen releasing in PdHx, restrict the industrial application of Pd-based HER catalysts.	Hydrogen	69-77	pyruvate dehydrogenase complex component X	Homo sapiens	91-95
34994569-0	2022	Interfacing g-C3N4 Nanosheets with CdS Nanorods for Enhanced Photocatalytic Hydrogen Evolution: An Ultrafast Investigation.	Hydrogen	76-84	CDP-diacylglycerol synthase 1	Homo sapiens	35-38
18245498-11	2008	Docking data suggested that quercetin, but not resveratrol, formed a hydrogen bond with the backbone amide group of Ser(212), which is the key interaction for stabilizing the inactive conformation of the activation loop of MEK1.	Hydrogen	69-77	mitogen-activated protein kinase kinase 1	Homo sapiens	223-227
34995071-8	2022	It starts with the hydrogen abstraction from CH4 by a Cl radical resulting in HCl and CH3 followed by a halogenation step where CCl4 molecules react with the available CH3 radicals, yielding CH3Cl.	Hydrogen	19-27	C-C motif chemokine ligand 4	Homo sapiens	128-132
34995071-9	2022	By analogy, the CH3Cl enters another hydrogen abstraction by Cl, producing HCl and the CH2Cl radical, which again undergoes a halogenation step with CCl4, generating CH2Cl2.	Hydrogen	37-45	C-C motif chemokine ligand 4	Homo sapiens	149-153
24499487-2	2014	GLCE (glucuronic acid epimerase) is a critical enzyme involved in HS synthesis, which converts GlcA (D-glucuronic acid) into IdoA (L-iduronic acid).	Hydrogen	66-68	glucuronic acid epimerase	Rattus norvegicus	0-4
24499487-2	2014	GLCE (glucuronic acid epimerase) is a critical enzyme involved in HS synthesis, which converts GlcA (D-glucuronic acid) into IdoA (L-iduronic acid).	Hydrogen	66-68	glucuronic acid epimerase	Rattus norvegicus	6-31
18166063-3	2008	Factors such as hydrogen bonding between CsF and the tert-alcohol solvent, the formation of a tert-alcohol solvated fluoride, and hydrogen bonding between the sulfonate leaving group and the tert-alcohol appear to contribute to the dramatic increase in the rate of the nucleophilic fluorination reaction in the absence of any kind of catalyst.	Hydrogen	16-24	colony stimulating factor 2	Homo sapiens	41-44
24734702-5	2014	H2-TPR study revealed the oxygen storage capacity of the catalyst.	Hydrogen	0-2	translocated promoter region, nuclear basket protein	Homo sapiens	3-6
24607902-8	2014	Taken together, our results suggest that hydrogen bonding is a major determinant in the interaction of Doa1/PFU with Hse1/SH3.	Hydrogen	41-49	phospholipase A2 activating protein	Homo sapiens	103-107
35057408-5	2022	1H NMR titration experiments in DMSO-d6/0.5% water solution reveal that trans-1 exhibits a strong preference for dihydrogenphosphate (H2PO4-) over other anions (Cl-, MeCO2-, and PhCO2-), whereas the photogenerated metastable cis-1 shows lower affinity for the H2PO4- anion.	Hydrogen	0-2	cytokine inducible SH2 containing protein	Homo sapiens	225-230
35021945-6	2022	The molecular docking studies revealed that compound 5e has strong interaction with the CLK kinase and protein kinase II through hydrogen binding Asp325 and Lys290.	Hydrogen	129-137	CDC like kinase 2	Homo sapiens	88-98
18175975-1	2008	N-Heterocyclic carbenes (NHCs) were generated in-situ from imidazolium and imidazolinium salts by deprotonation of C-2 hydrogen and were used as ligands in the copper-catalyzed addition of diethylzinc to N-sulfonylimines.	Hydrogen	119-127	complement C2	Homo sapiens	115-118
34874372-3	2022	Steady-state fluorescence studies suggested that static complexes were formed between hCNCs and alpha-amylase or alpha-glucosidase via a spontaneous and endothermic approach, which was driven by both hydrophobic interactions and hydrogen bonding.	Hydrogen	229-237	sucrase-isomaltase	Homo sapiens	113-130
24487479-2	2014	The designed (Aib-(S)Ant-Aib)n and (Aib-(S)Ant-Pro)n oligomers display a well-defined folded conformation featuring intramolecular mixed hydrogen bonding (7/11) and intra-residual (6/5) H-bonding interactions, respectively.	Hydrogen	137-145	ANIB1	Homo sapiens	14-17
24081321-3	2014	These findings suggest that HyaB and HydA can function as uptake hydrogenases that couple the oxidation of H2 to the reduction of amaranth to sustain cellular growth.	Hydrogen	107-109	4Fe-4S dicluster domain-containing protein	Shewanella oneidensis MR-1	37-41
18942697-6	2008	The equations are tested for an external set of 99 additional compounds including very different nitrogen bases such as ortho-substituted pyridines, polyazines and azoles.Theoretical calculations give a reliable estimation of hydrogen-bond basicity provided that the populations of the different isomers of the bases are taken into account by using the Boltzmann law, and that a specific halogen-bond interaction with the solvent CCl4 is considered for polybasic molecules.The pKHB scale can thus be extended to important classes of species experimentally inaccessible in CCl4, to polynitrogen compounds and to molecules of biological significance.	Hydrogen	226-234	C-C motif chemokine ligand 4	Homo sapiens	430-434
24355099-10	2014	On the other hand, intracerebroventricular (icv) T-2 toxin injection resulted in a rapid (&lt;1h) reduction in food intake.	Hydrogen	94-96	solute carrier family 25 member 5	Homo sapiens	49-52
17985212-7	2007	1H-15N NMR HSQC spectra of His8-Tcl-1 and of His8-GFP prepared from 50 ml cultures showed excellent chemical shift dispersion, consistent with well folded states in solution suitable for structure determination.	Hydrogen	0-2	TCL1 family AKT coactivator A	Homo sapiens	32-37
24624315-10	2014	Second, although the static co-crystal structure shows two large hydrogen-bonding networks in the GP1/hTfR1 interface, our simulations indicate that one of them may not be important for tight binding.	Hydrogen	65-73	GTP binding protein 1	Homo sapiens	98-101
35002404-7	2022	Screening of 5000+ compounds filtered two efficacious compounds (Artocarpetin and 5-Galloylquinic acid) capable of establishing hydrogen bond connections with both IDH variants.	Hydrogen	128-136	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	164-167
24476198-3	2014	Interestingly, MPTS exhibits a normal SED hydrodynamics in dicationic [C6(MIm)2][NTf2]2, in spite of the fact that dicationic ionic liquid contains two cationic sites bearing acidic hydrogen (C2-H) which may be available to form stronger interaction with the negatively charged MPTS.	Hydrogen	182-190	molybdenum cofactor synthesis 2	Homo sapiens	15-19
17973427-6	2007	15 ppm, suggesting a hydrogen bond with the CO2Me group.	Hydrogen	21-29	complement C2	Homo sapiens	44-47
24476198-5	2014	Superstick behavior of MPTS in monocationic IL has been attributed to its specific hydrogen bonding interaction with the corresponding imidazolium cation.	Hydrogen	83-91	molybdenum cofactor synthesis 2	Homo sapiens	23-27
24476198-7	2014	Mass spectral analysis demonstrates that positively charged (imidazolium) sites in dicationic IL are strongly associated with negatively charged bis-(trifluoromethylsulfonyl)amide anion (NTf2(-)), which in turn makes it difficult for imidazolim cation to have stronger hydrogen bonding interaction with bulkier negatively charged molecule MPTS.	Hydrogen	269-277	molybdenum cofactor synthesis 2	Homo sapiens	339-343
17973529-0	2007	TFA-mediated tandem Friedel-Crafts alkylation/cyclization/hydrogen transfer process for the synthesis of flavylium compounds.	Hydrogen	58-66	coagulation factor III, tissue factor	Homo sapiens	0-3
24757500-7	2014	Binding simulation with LSD1 indicated that the aromatic rings of the compounds and the amino group of the cyclopropylamine were important for the interaction with LSD1, and that the stereochemistry of the 1,2-disubstituted cyclopropane ring affected the position of the aromatic rings and the hydrogen bond formation of the amino group in the LSD1 catalytic site.	Hydrogen	294-302	lysine demethylase 1A	Homo sapiens	164-168
17960914-2	2007	The X-ray crystal structure of the Rev1p-DNA-dCTP ternary complex showed that Rev1p utilizes an unusual mechanism of nucleotide incorporation whereby the template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydrogen bonds with the incoming dCTP.	Hydrogen	246-254	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	78-83
24757500-7	2014	Binding simulation with LSD1 indicated that the aromatic rings of the compounds and the amino group of the cyclopropylamine were important for the interaction with LSD1, and that the stereochemistry of the 1,2-disubstituted cyclopropane ring affected the position of the aromatic rings and the hydrogen bond formation of the amino group in the LSD1 catalytic site.	Hydrogen	294-302	lysine demethylase 1A	Homo sapiens	164-168
17914868-6	2007	In this study, we report residue-specific stabilities of Ezrin CERMAD at the Ezrin N/C interface obtained using hydrogen-deuterium exchange NMR.	Hydrogen	112-120	ezrin	Homo sapiens	57-62
24382574-1	2014	The quantum solid para-hydrogen (p-H2) has emerged as a new host for matrix isolation experiments.	Hydrogen	18-31	polyhomeotic homolog 2	Homo sapiens	33-37
17914868-6	2007	In this study, we report residue-specific stabilities of Ezrin CERMAD at the Ezrin N/C interface obtained using hydrogen-deuterium exchange NMR.	Hydrogen	112-120	ezrin	Homo sapiens	77-82
24422526-4	2014	The TTR-Glab complex structure revealed a novel binding mode including a CH-pi interaction with A108 and a hydrogen bond with K15.	Hydrogen	107-115	transthyretin	Homo sapiens	4-7
17914843-2	2007	1H NMR and fluorescence titrations revealed that receptors 2a and 2b, incorporating suitable positioned amine and oxime moieties, are able to form strong 1:1 complexes (Ka1 approximately 10(5) M-1) with dodecyl alpha- and beta-maltoside in chloroform solutions.	Hydrogen	0-2	glutamate ionotropic receptor kainate type subunit 4	Homo sapiens	169-172
24803973-0	2014	Spin-State Effects on the Thermal Dihydrogen Release from Solid-State [MH(eta2-H2)dppe2]+ (M = Fe, Ru, Os) Organometallic Complexes for Hydrogen Storage Applications.	Hydrogen	136-144	spindlin 1	Homo sapiens	0-4
17919035-1	2007	In situ neutron inelastic scattering experiments on hydrogen adsorbed into a fully deutrated tetrahydrofuran-water ice clathrate show that the adsorbed hydrogen has three rotational excitations (transitions between J=0 and 1 states) at approximately 14 meV in both energy gain and loss.	Hydrogen	152-160	immunoglobulin kappa joining 1	Homo sapiens	215-224
24328091-5	2014	We perform statistical analysis using more than 30 descriptors related to the sequence, physicochemical, structural, and energetic properties of the GPCR binding sites-we find that the chemical variability of antagonists significantly correlates with the binding site hydrophobicity and anticorrelates with the number of hydrogen bond donors in the binding site.	Hydrogen	321-329	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	149-153
17930665-4	2007	N-molecule chains of He atoms and H2 molecules at equilibrium and stretched geometries show an effective scaling of O[N(2.6)] and O[N(5.6)] for MP2 and MP3 theories.	Hydrogen	34-36	tryptase pseudogene 1	Homo sapiens	144-147
24320242-5	2014	The highly dynamic nature of hydrogen bonds in the high-temperature phases manifests in the Raman and IR spectra through very large bandwidth of modes involving vibrations of the NH2 (ND2) groups.	Hydrogen	29-37	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	184-187
17766376-5	2007	That introduction of a non-hydrogen-bonded cross-strand Trp-Trp pair within the hPin1 WW domain eliminates function may provide a rationale for why this energetically favorable pairwise interaction has not yet been identified in WW domains or any other biologically evolved protein with known three-dimensional structure.	Hydrogen	27-35	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	80-85
24344770-1	2014	An arylpalladium PNF-type pincer complex reacts with water and anilines under very mild conditions, providing access to new PNO- and PNN-pincer complexes with concomitant hydrogen transfer to the ligand core.	Hydrogen	171-179	pinin, desmosome associated protein	Homo sapiens	133-136
17632125-4	2007	The Ubp3 N-terminal domain binds within a hydrophobic cavity on the surface of the Bre5 NTF2-like domain subunit with conserved residues within both proteins interacting predominantly through antiparallel beta-sheet hydrogen bonds and van der Waals contacts.	Hydrogen	216-224	Bre5p	Saccharomyces cerevisiae S288C	83-87
26276186-0	2014	Synthesized Blue Fluorescent Protein Analogue with Tunable Colors from Excited-State Intramolecular Proton Transfer through an N-H   N Hydrogen Bond.	Hydrogen	135-143	ring finger protein 112	Homo sapiens	12-36
17624704-8	2007	Moreover, by docking techniques, these compounds fitted LTB well via hydrogen bonds and hydrophobic contacts with amino acid residues of LTB.	Hydrogen	69-77	lymphotoxin B	Mus musculus	56-59
24347068-3	2014	Among the three Ir/CNF samples, Ir/CNF-T showed an excellent catalytic activity and chemoselectivity towards hydrogenation of functionalized nitroarenes and imines; the corresponding aniline derivatives were obtained with high turnover numbers at ambient temperature under 10 tm of H2 , and the catalyst is reusable.	Hydrogen	282-284	NPHS1 adhesion molecule, nephrin	Homo sapiens	19-22
24376700-9	2013	The phosphorylation of EGFR at Tyr1068 and Nrf2 up-regulation expression in the rat lungs challenged by CS exposure were also abrogated by hydrogen-rich saline.	Hydrogen	139-147	epidermal growth factor receptor	Rattus norvegicus	23-27
17713901-3	2007	Together with previous results, the current work shows a highly conserved water-involved hydrogen bonding (HB) network in both CDK2- and CDK5-indirubin combinations to complete information from the X-ray crystallography.	Hydrogen	89-97	cyclin dependent kinase 5	Homo sapiens	137-141
17431936-2	2007	For beta-maltose, MP2 and local MP2 calculations using the 6-311++G** basis set are in good agreement, predicting a global minimum gas-phase conformation with a counterclockwise hydrogen bond network and the experimentally-observed intersaccharide hydrogen bonding arrangement.	Hydrogen	178-186	tryptase pseudogene 1	Homo sapiens	18-21
24144240-3	2013	Docking of ligands 2 (MOR selective) and 10 (MOR/KOR dual selective) to the three opioid receptor crystal structures revealed a nonconserved-residue-facilitated hydrogen-bonding network that could be responsible for their distinctive selectivity profiles.	Hydrogen	161-169	opioid receptor, kappa 1	Mus musculus	49-52
17431936-2	2007	For beta-maltose, MP2 and local MP2 calculations using the 6-311++G** basis set are in good agreement, predicting a global minimum gas-phase conformation with a counterclockwise hydrogen bond network and the experimentally-observed intersaccharide hydrogen bonding arrangement.	Hydrogen	178-186	tryptase pseudogene 1	Homo sapiens	32-35
17431936-2	2007	For beta-maltose, MP2 and local MP2 calculations using the 6-311++G** basis set are in good agreement, predicting a global minimum gas-phase conformation with a counterclockwise hydrogen bond network and the experimentally-observed intersaccharide hydrogen bonding arrangement.	Hydrogen	248-256	tryptase pseudogene 1	Homo sapiens	18-21
24102610-2	2013	Since in the crystals of N-acetyl-l-cysteine the thiol group is involved in intermolecular hydrogen bonds not as a donor only (bonds S-H   O) but also as an acceptor (bonds N-H   S), increasing the pressure does not result in phase transitions.	Hydrogen	91-99	shadow of prion protein	Homo sapiens	133-140
24102610-7	2013	Precise single-crystal X-ray diffraction and polarized Raman spectroscopy structural data reveal the formation of a bifurcated S-H   O hydrogen bond with increasing pressure starting with ~1.5 GPa.	Hydrogen	135-143	shadow of prion protein	Homo sapiens	127-134
17431936-2	2007	For beta-maltose, MP2 and local MP2 calculations using the 6-311++G** basis set are in good agreement, predicting a global minimum gas-phase conformation with a counterclockwise hydrogen bond network and the experimentally-observed intersaccharide hydrogen bonding arrangement.	Hydrogen	248-256	tryptase pseudogene 1	Homo sapiens	32-35
24102610-8	2013	The analysis of the vibrational bands in Raman spectra has shown that different donor and acceptor groups start "feeling" the formation of the bifurcated S-H   O hydrogen bond in different pressure ranges.	Hydrogen	162-170	shadow of prion protein	Homo sapiens	154-161
18019136-3	2007	DTDA and TTDA with two and three thiophene rings, self-assembled into highly ordered long-range two dimensional structures via hydrogen bondings, while QTDA with four thiophene rings formed short-range ordered structure with hexagonal symmetry.	Hydrogen	127-135	general transcription factor IIH subunit 5	Homo sapiens	9-13
24160998-1	2013	The effect of vibrational excitation and relaxation of the hydroxyl stretch on the hydrogen-bond structure and dynamics of stereoselectively synthesized syn-tetrol and anti-tetrol dissolved in deuterated chloroform are investigated via a mixed quantum-classical molecular dynamics simulation.	Hydrogen	83-91	synemin	Homo sapiens	141-144
18019142-1	2007	High quality wurtzite CdS nanowires have been synthesized by thermal evaporation of CdS powder onto Si substrate in the presence of Au catalyst at 650 degrees C by using pure H2 as a carrier gas.	Hydrogen	175-177	CDP-diacylglycerol synthase 1	Homo sapiens	22-25
17685497-0	2007	Hydrogen migration and vinylidene pathway for formation of methane in the 193 nm photodissociation of propene: CH3CH=CH2 and CD3CD=CD2.	Hydrogen	0-8	CD2 molecule	Homo sapiens	131-134
24348168-3	2013	TPR and XPS suggest that the metal in all catalysts is reduced after the pretreatment with H2 at 673 K. The TPR trace of the PdNRX catalyst shows that the support surface groups are greatly modified as a consequence of the use of HNO3 during the catalyst preparation.	Hydrogen	91-93	translocated promoter region, nuclear basket protein	Homo sapiens	108-111
17588602-6	2007	However, the hydroxyl group of Ser39 of NAP5 additionally forms a hydrogen bond (2.5 A) with His57 NE2 of the catalytic triad, replacing the hydrogen bond of Ser195 OG to the latter in the native structure, resulting in an interaction that has not been observed before.	Hydrogen	66-74	NCK associated protein 5	Homo sapiens	40-44
23881716-1	2013	The synthesis of (-)-demethyl (C-11) cezomycin was achieved through an efficient route that features the use of a Kulinkovich reaction to couple two multifunctionality-containing fragments and a cascade of ring opening of cyclopropanol/1,5-hydrogen shift/desilylation-oxidation.	Hydrogen	240-248	aldo-keto reductase family 1 member C4	Homo sapiens	31-35
17588602-6	2007	However, the hydroxyl group of Ser39 of NAP5 additionally forms a hydrogen bond (2.5 A) with His57 NE2 of the catalytic triad, replacing the hydrogen bond of Ser195 OG to the latter in the native structure, resulting in an interaction that has not been observed before.	Hydrogen	141-149	NCK associated protein 5	Homo sapiens	40-44
17608456-5	2007	A bimolecular reaction of DF with H or H2 is found to have a significantly lower barrier than unimolecular decomposition through C-O beta-scission.	Hydrogen	39-41	metabolism of cobalamin associated B	Homo sapiens	129-137
24111652-0	2013	Hydrogen-oxidizing hydrogenases 1 and 2 of Escherichia coli regulate the onset of hydrogen evolution and ATPase activity, respectively, during glucose fermentation at alkaline pH.	Hydrogen	19-27	ATPase	Escherichia coli	105-111
17521807-4	2007	The presence of salt (NaCl) in the deionized water solutions was found to have a more pronounced sensitizing effect upon the photolysis of 2,4-DNT, yielding half lives of the order of 1h.	Hydrogen	184-186	5', 3'-nucleotidase, cytosolic	Homo sapiens	143-146
24121323-0	2013	Hydrogen-bond network and pH sensitivity in human transthyretin.	Hydrogen	0-8	transthyretin	Homo sapiens	50-63
24121323-8	2013	This hydrogen-bond network is involved in monomer-monomer and dimer-dimer interactions, suggesting that the double protonation of His88 by acidification breaks the hydrogen-bond network and causes the destabilization of the TTR tetramer.	Hydrogen	5-13	transthyretin	Homo sapiens	224-227
24121323-8	2013	This hydrogen-bond network is involved in monomer-monomer and dimer-dimer interactions, suggesting that the double protonation of His88 by acidification breaks the hydrogen-bond network and causes the destabilization of the TTR tetramer.	Hydrogen	164-172	transthyretin	Homo sapiens	224-227
17405159-3	2007	The increments have been fitted to quantum chemical ab initio interaction energies of 81 small hydrogen-bonded complexes determined at the level of second-order Moller-Plesset perturbation theory (MP2).	Hydrogen	95-103	tryptase pseudogene 1	Homo sapiens	197-200
25419488-3	2013	Here, RNP-4F is believed to initially bind to a recognition sequence on U6-snRNA, serving as a chaperone to facilitate its association with U4-snRNA by intermolecular hydrogen bonding.	Hydrogen	167-175	small nuclear RNA U6 at 96A a	Drosophila melanogaster	72-80
24022263-1	2013	We use femtosecond optical Kerr effect (OKE) spectroscopy to perform time- and wavelength-resolved pump-probe measurements on the energetics and lifetimes of transverse optical phonons and J = 2 rotons in solid para-hydrogen (pH2).	Hydrogen	216-224	polyhomeotic homolog 2	Homo sapiens	226-229
24030544-6	2013	These comparative studies show that Cat4, although based on a noble metal, is about four times less active, while Cat2 and Cat3 produce more than one hundred times less hydrogen than Cat1.	Hydrogen	169-177	solute carrier family 7 member 3	Homo sapiens	123-127
17547394-14	2007	A molecular association was observed between chloroform and oxomolybdenum(V) corrole 1 through MoO...H/CCl3 hydrogen-bonding interactions.	Hydrogen	108-116	C-C motif chemokine ligand 3	Homo sapiens	103-107
26029768-3	2013	The ordered morphologies of PCL-b-PVBU diblock copolymers changed from a lamellar, hexagonally packed cylinder to a sphere with respect to the content of the hydrogen bond segment.	Hydrogen	158-166	PHD finger protein 1	Homo sapiens	28-31
26029768-5	2013	In addition, bio-complementary PCL-b-PVBU/9-hexadecyladenine (AC16) hierarchical supramolecular complexes formed through strong cooperative hydrogen bonding between the uracil group of PVBU and the adenine group of A-C16.	Hydrogen	140-148	PHD finger protein 1	Homo sapiens	31-34
17397058-7	2007	The results led to two striking findings: (1) in agreement with bioinformatics prediction, the N- and C-termini of Nogo-B were experimentally demonstrated to be intrinsically unstructured by CD, two-dimensional 1H 15N NMR HSQC, hydrogen exchange, and 15N heteronuclear NOE characterization.	Hydrogen	211-213	reticulon 4	Homo sapiens	115-121
17397058-7	2007	The results led to two striking findings: (1) in agreement with bioinformatics prediction, the N- and C-termini of Nogo-B were experimentally demonstrated to be intrinsically unstructured by CD, two-dimensional 1H 15N NMR HSQC, hydrogen exchange, and 15N heteronuclear NOE characterization.	Hydrogen	228-236	reticulon 4	Homo sapiens	115-121
17442338-5	2007	By combining direct mutagenesis and kinetic studies, we found that the elimination of this hydrogen bond did not affect the affinity of the enzyme for its steroid substrate but led to a slight but significant increase of its catalytic efficiency (k(cat)/K(m)), suggesting a role for K31 in the release of the steroidal product at the end of the reaction.	Hydrogen	91-99	keratin 31	Mus musculus	283-286
16950647-0	2007	A short hydrogen bond investigation by polarized Raman spectra of Co2+ and Zn2+ salts of pyromellitic acid.	Hydrogen	8-16	complement C2	Homo sapiens	66-69
17488022-7	2007	All enzyme-treated starches showed a mixture of B- and V-type X-ray diffraction patterns, and 1H NMR spectra showed a significant increase of alpha-1,6 linkages.	Hydrogen	94-96	adrenoceptor alpha 1D	Homo sapiens	142-151
17447732-14	2007	The dissociation rate constants and the slow-binding association rate constants for NAD+ show a complex temperature dependence with both enzymes; however, the cofactor always dissociates more rapidly from Tc-SAHH than from Hs-SAHH, the ratio being around 80-fold at 37 degrees C, and the cofactor binds more rapidly to Hs-SAHH than to Tc-SAHH above approximately 16 degrees C. These features present an opening for selective inhibition of Tc-SAHH over Hs-SAHH, demonstrated with the thioamide analogues of NAD+ and NADH.	Hydrogen	223-225	adenosylhomocysteinase	Homo sapiens	226-230
17447732-14	2007	The dissociation rate constants and the slow-binding association rate constants for NAD+ show a complex temperature dependence with both enzymes; however, the cofactor always dissociates more rapidly from Tc-SAHH than from Hs-SAHH, the ratio being around 80-fold at 37 degrees C, and the cofactor binds more rapidly to Hs-SAHH than to Tc-SAHH above approximately 16 degrees C. These features present an opening for selective inhibition of Tc-SAHH over Hs-SAHH, demonstrated with the thioamide analogues of NAD+ and NADH.	Hydrogen	223-225	adenosylhomocysteinase	Homo sapiens	226-230
17447732-14	2007	The dissociation rate constants and the slow-binding association rate constants for NAD+ show a complex temperature dependence with both enzymes; however, the cofactor always dissociates more rapidly from Tc-SAHH than from Hs-SAHH, the ratio being around 80-fold at 37 degrees C, and the cofactor binds more rapidly to Hs-SAHH than to Tc-SAHH above approximately 16 degrees C. These features present an opening for selective inhibition of Tc-SAHH over Hs-SAHH, demonstrated with the thioamide analogues of NAD+ and NADH.	Hydrogen	223-225	adenosylhomocysteinase	Homo sapiens	226-230
17447763-3	2007	Besides, specific photofragments including the formation of radical cation after hydrogen loss are observed for TrpH+ that are not found for TyrH+.	Hydrogen	81-89	tryptophan hydroxylase 1	Homo sapiens	112-116
17407360-0	2007	Regioselective alkenylation of aromatic ketones with alkenylboronates using a RuH2(CO)(PPh3)3 catalyst via carbon-hydrogen bond cleavage.	Hydrogen	114-122	protein phosphatase 4 catalytic subunit	Homo sapiens	87-91
17388514-5	2007	The most stable isomer is the doubly N1-H...O hydrogen-bonded HB4 form, with D(e)[CCSD(T)]= -19.04 kcal/mol.	Hydrogen	46-54	keratin 84	Homo sapiens	62-65
17388323-8	2007	Furthermore, the interaction energies (by MP2) of H2 with glycine, the glycine dimer, and imidazolium chloride amount to 2.78, 5.00, and 6.30 kJ mol-1, respectively.	Hydrogen	50-52	tryptase pseudogene 1	Homo sapiens	42-45
17388441-9	2007	The hydrogen bond interaction and vibration-vibration interaction between the heme and solvent molecules dominates the energy transfer in native myoglobin aqueous solution and native myoglobin glycerol solutions.	Hydrogen	4-12	myoglobin	Homo sapiens	145-154
17388441-9	2007	The hydrogen bond interaction and vibration-vibration interaction between the heme and solvent molecules dominates the energy transfer in native myoglobin aqueous solution and native myoglobin glycerol solutions.	Hydrogen	4-12	myoglobin	Homo sapiens	183-192
17388441-12	2007	For native myoglobin in a nonpolar solvent solution, hydrogen bonds between heme isopropionate side chains and nearby protein residues, absent in the modified myoglobin nonpolar solvent solution, are key interactions influencing the relaxation pathways.	Hydrogen	53-61	myoglobin	Homo sapiens	11-20
17388441-12	2007	For native myoglobin in a nonpolar solvent solution, hydrogen bonds between heme isopropionate side chains and nearby protein residues, absent in the modified myoglobin nonpolar solvent solution, are key interactions influencing the relaxation pathways.	Hydrogen	53-61	myoglobin	Homo sapiens	159-168
17274604-3	2007	Structures and energies of the gas-phase species produced during and after the various unimolecular decomposition reactions of methyltrichlorosilane (MTS) with the presence of H2 carrier gas were determined using second-order perturbation theory (MP2).	Hydrogen	176-178	tryptase pseudogene 1	Homo sapiens	247-250
17249647-3	2007	The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 microM &lt; IC50 &lt; 0.6 microM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor.	Hydrogen	221-229	hemoglobin subunit alpha pseudogene 1	Homo sapiens	285-289
17266226-4	2007	The trans-COOR conformer with hydrogen bonding between the OH group and the C=O group attached to the same chiral carbon is dominant for dialkyl tartrates both in vacuum and in CCl4.	Hydrogen	30-38	C-C motif chemokine ligand 4	Homo sapiens	177-181
17260958-0	2007	Investigation of the structural stability of hUBF HMG box 5 by native-state hydrogen exchange.	Hydrogen	76-84	upstream binding transcription factor	Homo sapiens	45-49
17074421-4	2007	Trx mRNA and protein levels in neurons with mitochondrial dysfunction decreased in a dose- and time-dependent manner (mRNA: 25-150 microM H(2)O(2) for 1h and 50 microM H(2)O(2) for 1-3h; protein: 25-150 microM H(2)O(2) for 1h and 50 microM H(2)O(2) for 1-4h), while those in control neurons had no significant changes (50-250 microM H(2)O(2) for 1h).	Hydrogen	151-153	thioredoxin	Homo sapiens	0-3
17074421-4	2007	Trx mRNA and protein levels in neurons with mitochondrial dysfunction decreased in a dose- and time-dependent manner (mRNA: 25-150 microM H(2)O(2) for 1h and 50 microM H(2)O(2) for 1-3h; protein: 25-150 microM H(2)O(2) for 1h and 50 microM H(2)O(2) for 1-4h), while those in control neurons had no significant changes (50-250 microM H(2)O(2) for 1h).	Hydrogen	223-225	thioredoxin	Homo sapiens	0-3
17074421-4	2007	Trx mRNA and protein levels in neurons with mitochondrial dysfunction decreased in a dose- and time-dependent manner (mRNA: 25-150 microM H(2)O(2) for 1h and 50 microM H(2)O(2) for 1-3h; protein: 25-150 microM H(2)O(2) for 1h and 50 microM H(2)O(2) for 1-4h), while those in control neurons had no significant changes (50-250 microM H(2)O(2) for 1h).	Hydrogen	223-225	thioredoxin	Homo sapiens	0-3
17146529-1	2006	The condensation process catalysed by 2-amino-3-oxobutyrate CoA ligase (KBL; also known as 2-amino-3-ketobutyrate ligase) involves the loss of the pro-R hydrogen atom of glycine and occurs with the inversion of stereochemistry; a similar scenario is envisaged for the condensation step of other alpha-oxoamine synthases.	Hydrogen	153-161	glycine C-acetyltransferase	Homo sapiens	72-75
17181352-1	2006	Binding energies for hydrogen-bonded complexes of six cyclic ethers with five hydrogen-bond donor molecules that mimic selected amino acid side chains have been calculated at the MP2/6-31G*, MP2/6-31+G*, MP2/6-311++G**(single point), and MP2/aug-cc-pvtz levels, using geometries obtained with or without counterpoise corrections throughout the geometry optimization.	Hydrogen	21-29	tryptase pseudogene 1	Homo sapiens	179-182
17181352-1	2006	Binding energies for hydrogen-bonded complexes of six cyclic ethers with five hydrogen-bond donor molecules that mimic selected amino acid side chains have been calculated at the MP2/6-31G*, MP2/6-31+G*, MP2/6-311++G**(single point), and MP2/aug-cc-pvtz levels, using geometries obtained with or without counterpoise corrections throughout the geometry optimization.	Hydrogen	21-29	tryptase pseudogene 1	Homo sapiens	191-194
17181352-1	2006	Binding energies for hydrogen-bonded complexes of six cyclic ethers with five hydrogen-bond donor molecules that mimic selected amino acid side chains have been calculated at the MP2/6-31G*, MP2/6-31+G*, MP2/6-311++G**(single point), and MP2/aug-cc-pvtz levels, using geometries obtained with or without counterpoise corrections throughout the geometry optimization.	Hydrogen	21-29	tryptase pseudogene 1	Homo sapiens	191-194
17181352-1	2006	Binding energies for hydrogen-bonded complexes of six cyclic ethers with five hydrogen-bond donor molecules that mimic selected amino acid side chains have been calculated at the MP2/6-31G*, MP2/6-31+G*, MP2/6-311++G**(single point), and MP2/aug-cc-pvtz levels, using geometries obtained with or without counterpoise corrections throughout the geometry optimization.	Hydrogen	21-29	tryptase pseudogene 1	Homo sapiens	191-194
17181352-3	2006	The authors conclude that the O...H distances in the hydrogen bonds and binding energies for the studied systems may be determined with uncertainties of up to 0.08 A and 1-2 kcal/mol, respectively, in comparison with the MP2/aug-cc-pvtz values at a reasonable computational cost by performing standard geometry optimization at the MP2/6-31+G* level.	Hydrogen	53-61	tryptase pseudogene 1	Homo sapiens	221-224
17181352-3	2006	The authors conclude that the O...H distances in the hydrogen bonds and binding energies for the studied systems may be determined with uncertainties of up to 0.08 A and 1-2 kcal/mol, respectively, in comparison with the MP2/aug-cc-pvtz values at a reasonable computational cost by performing standard geometry optimization at the MP2/6-31+G* level.	Hydrogen	53-61	tryptase pseudogene 1	Homo sapiens	331-334
17177443-10	2006	Theoretical results also identified interactions between the Hb6 and beta-phosphate oxygen of the UDP and a low-barrier hydrogen bond between the nucleophile and the catalytic base D291.	Hydrogen	120-128	keratin 86	Homo sapiens	61-64
23995220-2	2013	The assemblies in solvated states were characterized using cryogenic transmission electron microscopy (cryo-TEM), and their nanostructures were modulated by the synergistic interactions of pi-pi stacking and hydrogen bonds.	Hydrogen	208-216	MFT2	Homo sapiens	108-111
17147386-2	2006	UV-vis and 1H NMR titration clearly showed that the complexation between H4L and zinc(II) acetate affords 1:3 complex [LZn3]2+ via a highly cooperative process.	Hydrogen	11-13	H4 clustered histone 7	Homo sapiens	73-107
17139084-2	2006	Here, the 1.55 A crystal structure of the mouse p53 core domain with a molecule of tris(hydroxymethyl)aminomethane (Tris) bound through multiple hydrogen bonds to a region of p53 shown to be important for repair of a subset of tumor-derived p53-stability mutations is reported.	Hydrogen	145-153	transformation related protein 53, pseudogene	Mus musculus	48-51
24098480-0	2013	Oligomerization interface of RAGE receptor revealed by MS-monitored hydrogen deuterium exchange.	Hydrogen	68-76	advanced glycosylation end-product specific receptor	Homo sapiens	29-33
24098480-4	2013	In this study, we used hydrogen-deuterium exchange and mass spectrometry to map structural differences between the monomeric and oligomeric forms of RAGE.	Hydrogen	23-31	advanced glycosylation end-product specific receptor	Homo sapiens	149-153
17139084-2	2006	Here, the 1.55 A crystal structure of the mouse p53 core domain with a molecule of tris(hydroxymethyl)aminomethane (Tris) bound through multiple hydrogen bonds to a region of p53 shown to be important for repair of a subset of tumor-derived p53-stability mutations is reported.	Hydrogen	145-153	transformation related protein 53, pseudogene	Mus musculus	175-178
17139084-2	2006	Here, the 1.55 A crystal structure of the mouse p53 core domain with a molecule of tris(hydroxymethyl)aminomethane (Tris) bound through multiple hydrogen bonds to a region of p53 shown to be important for repair of a subset of tumor-derived p53-stability mutations is reported.	Hydrogen	145-153	transformation related protein 53, pseudogene	Mus musculus	175-178
24071978-1	2013	Herein we describe NMR experiments and structural modifications of 4-methyl-2-phenylpyrimidine-N-acylhydrazone compounds (aryl-NAH) in order to discover if duplication of some signals in their 1H- and 13C-NMR spectra was related to a mixture of imine double bond stereoisomers (E/Z) or CO-NH bond conformers (syn and anti-periplanar).	Hydrogen	193-195	synemin	Homo sapiens	309-312
17125375-6	2006	This indicates electron transfer from NAD* to Acr+-Mes to give Acr*-Mes, which undergoes the electron-transfer reduction of MVA2+-PtC, leading to the efficient hydrogen evolution.	Hydrogen	160-168	acrosin	Homo sapiens	46-49
17125375-6	2006	This indicates electron transfer from NAD* to Acr+-Mes to give Acr*-Mes, which undergoes the electron-transfer reduction of MVA2+-PtC, leading to the efficient hydrogen evolution.	Hydrogen	160-168	acrosin	Homo sapiens	63-66
17105194-5	2006	Herein we report identification of a conserved Mc b5 core 2 packing motif that plays a key role in stabilizing apoprotein conformation in the vicinity of Trp-22, thereby compensating for the presence of Ser at position 71: a pi-stacking interaction between the side chains of Trp-22 and His-15 that is extended by hydrogen bonding between the side chains of His-15, Ser-20, and Glu-11.	Hydrogen	314-322	cytochrome b5 type A	Homo sapiens	47-52
24098215-4	2013	Intra-molecular hydrogen bonding involving the amino group and ester carbonyl helps to lock the syn conformation of the ester with respect to the amino group.	Hydrogen	16-24	synemin	Homo sapiens	96-99
24028108-6	2013	The results show that delocalized electronic orbitals with covalent and hydrogen bonds are better described at the trimer level, and the FMO3-LCMO method is applicable to quantitative evaluations of a wide range of frontier orbitals in large biosystems.	Hydrogen	72-80	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	137-141
16979892-0	2006	Biochemical aromatization of 2-methyleneandrostenedione: stereochemistry of hydrogen removal at the C-1 position.	Hydrogen	76-84	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	100-103
23918711-1	2013	We present our study on the recognition of hydrogen isotopes by an open-cage fullerene through determination of binding affinity of isotopes H2/HD/D2 with the open-cage fullerene and comparison of their relative molecular sizes through kinetic-isotope-release experiments.	Hydrogen	43-51	relaxin 2	Homo sapiens	141-149
23918711-2	2013	We took advantage of isotope H2/D2 exchange that generated an equilibrium mixture of H2/HD/D2 in a stainless steel autoclave to conduct high-pressure hydrogen insertion into an open-cage fullerene.	Hydrogen	150-158	relaxin 2	Homo sapiens	85-93
16981707-4	2006	Thus, a new mechanism is proposed in which the active site-bound Fe2+ or Zn2+ serves as a Lewis acid to activate the 2-OH group of (S)-HPP and the epoxide ring is formed by the attack of the 2-OH group at C-1 coupled with the transfer of the C-1 hydrogen as a hydride ion to the bound FMN.	Hydrogen	246-254	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	205-208
23862564-2	2013	In contrast to the previously proposed syn-oxypalladation mechanism for acyclic monoallylic diols, calculations and experiments strongly suggest that hydrogen bonding templates a hydroxyl group and Pd addition across the alkene and provides a low energy pathway via anti-addition (anti-oxypalladation) followed by intramolecular proton transfer and anti-elimination of water.	Hydrogen	150-158	synemin	Homo sapiens	39-42
16981707-4	2006	Thus, a new mechanism is proposed in which the active site-bound Fe2+ or Zn2+ serves as a Lewis acid to activate the 2-OH group of (S)-HPP and the epoxide ring is formed by the attack of the 2-OH group at C-1 coupled with the transfer of the C-1 hydrogen as a hydride ion to the bound FMN.	Hydrogen	246-254	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	242-245
23907884-0	2013	1,7-Dideaza-2"-deoxy-6-nitronebularine: a pyrrolo[2,3-b]pyridine nucleoside with an intramolecular hydrogen bond stabilizing the syn conformation.	Hydrogen	99-107	synemin	Homo sapiens	129-132
16930618-10	2006	Studies of multiple substitutions at G20 and neighboring positions highlight the essential contributions of a glycine-specific tight turn and adjoining inter-subunit side-chain hydrogen bonds to the stability and architectural specificity of the intertwined dimer.	Hydrogen	177-185	chromosome 3 open reading frame 18	Homo sapiens	37-40
23780739-4	2013	The distal amino group of the hydrazide moiety addresses the acidic Asp 1 residue at the entrance of the S2 pocket by hydrogen bonding while also occupying the flat hydrophobic S1"-S2" area with its leucine-isoamylamide moiety.	Hydrogen	118-126	beta-secretase 2	Homo sapiens	68-73
16871519-2	2006	Using NMR titration experiments monitoring the shift of the two NH of the (thio)urea and the C-5 hydrogen of the heterocycle, the binding constants for some optically pure (thio)-ureas with the enantiomers of N-protected amino acid tetrabutylammonium salts were determined in CD3CN.	Hydrogen	97-105	complement C5	Homo sapiens	93-96
23740770-5	2013	Our results show that sulfation stabilizes the dimeric state of the CXCR4:SDF-1 complex through hydrogen bonding across the dimer interface, conformational changes in residues at the dimer interface, and an enhancement in electrostatic binding energies associated with dimerization.	Hydrogen	96-104	C-X-C motif chemokine receptor 4	Homo sapiens	68-73
16928122-0	2006	Ab initio study of the isomeric equilibrium of the HCN...H2O and H2O...HCN hydrogen-bonded clusters.	Hydrogen	75-83	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	71-74
23583779-1	2013	We studied hydrogen/deuterium-exchange reactions of peptide amide protons of GroES using two different techniques: (1) two-dimensional (1)H-(15)N transverse-optimized NMR spectroscopy and (2) the dimethylsulfoxide-quenched hydrogen-exchange method combined with conventional (1)H-(15)N heteronuclear single quantum coherence spectroscopy.	Hydrogen	223-231	chaperonin GroES	Escherichia coli	77-82
16928122-1	2006	An ab initio study of the stability, spectroscopic properties, and isomeric equilibrium of the hydrogen-bonded HCN...H2O and H2O...HCN isomers is presented.	Hydrogen	95-103	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	111-114
16893187-6	2006	We propose that a network of hydrogen bonds involving hUbc13-Asp(81) and Ub-Glu(64) positions Ub-Lys(63) proximal to the active site.	Hydrogen	29-37	ubiquitin conjugating enzyme E2 N	Homo sapiens	54-60
23758528-4	2013	We find that the hydrogen bond character--more specifically, the interactions between water and pIL--is the dominant parameter responsible for lowering the LCST of PNIPAM.	Hydrogen	17-25	serpin family A member 2 (gene/pseudogene)	Homo sapiens	96-99
23688558-8	2013	These results support the hypothesis that the modified hydrogen bonding donor/acceptors in DHP-mimic dihydropyrimidines and 4H-pyrans can interact differently with DHP binding sites, but, in addition, the data suggest that the binding sites of DHP in CaV1.3 and CaV1.2 LTCCs are very similar.	Hydrogen	55-63	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	262-268
16942283-0	2006	Direct dynamics study on the hydrogen abstraction reactions N2H4 + R--&gt;N2H3 + RH (R=NH2, CH3).	Hydrogen	29-37	NLR family pyrin domain containing 4	Homo sapiens	85-90
16866490-2	2006	Pd(PEt3)2(OTf)2, acting as an in situ source of Pd(PEt3)2, reacts with an alkyne and hydrogen via phosphine loss to form the detectable hydride-containing species Pd(PEt3)2(H)(CHPhCH2Ph), cis- and trans-Pd(PEt3)2(H)(CPh=CHPh), and Pd2(PEt3)3(H)(CHPhCH2Ph)2+, which map onto the reaction scheme predicted by density functional theory.	Hydrogen	85-93	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	231-234
23861918-10	2013	Molecular docking simulation indicated that ISL could stably form hydrogen bonds and aromatic interactions within the ATP-binding region of VEGFR-2.	Hydrogen	66-74	kinase insert domain receptor	Homo sapiens	140-147
16866878-10	2006	This similarity seems to be endowed by the conserved hydrogen bonding interactions with the guanine base-recognition loops and the magnesium ion that has a typical octahedral coordination shell identical to that in H-Ras.	Hydrogen	53-61	HRas proto-oncogene, GTPase	Homo sapiens	215-220
23592511-7	2013	RESULTS: Measurable hs-cTnI was identified in 1716 (93%) of the community-based study cohort and 499 (88%) of the healthy reference cohort.	Hydrogen	20-22	troponin I3, cardiac type	Homo sapiens	23-27
16839143-1	2006	Ethylenedithiotetrathiafulvalene (EDT-TTF) derivatives with N1-butyluracil or N1-phenyluracil moiety were designed and synthesized as new hydrogen-bonded electron-donor molecules with the aim of introducing multiple S...S interactions into the hydrogen-bonded structures composed of the TTF-nucleobase systems.	Hydrogen	138-146	ras homolog family member H	Homo sapiens	38-41
25165949-1	2013	First-principles calculations of the spin-orbit coupling in graphene with hydrogen adatoms in dense and dilute limits are presented.	Hydrogen	74-82	spindlin 1	Homo sapiens	37-41
25165949-2	2013	The chemisorbed hydrogen induces a giant local enhancement of spin-orbit coupling due to sp(3) hybridization which depends strongly on the local lattice distortion.	Hydrogen	16-24	spindlin 1	Homo sapiens	62-66
16839143-1	2006	Ethylenedithiotetrathiafulvalene (EDT-TTF) derivatives with N1-butyluracil or N1-phenyluracil moiety were designed and synthesized as new hydrogen-bonded electron-donor molecules with the aim of introducing multiple S...S interactions into the hydrogen-bonded structures composed of the TTF-nucleobase systems.	Hydrogen	138-146	ras homolog family member H	Homo sapiens	287-290
23679864-7	2013	The results of molecular dynamics simulations indicated that the dynamic stabilities of the hydrogen bonds between the inhibitors and Met318 should also be considered in designing the potent common inhibitors of the wild-type and T315I mutant of ABL.	Hydrogen	92-100	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	246-249
16839143-1	2006	Ethylenedithiotetrathiafulvalene (EDT-TTF) derivatives with N1-butyluracil or N1-phenyluracil moiety were designed and synthesized as new hydrogen-bonded electron-donor molecules with the aim of introducing multiple S...S interactions into the hydrogen-bonded structures composed of the TTF-nucleobase systems.	Hydrogen	244-252	ras homolog family member H	Homo sapiens	38-41
16839143-2	2006	In the crystals of the EDT-TTF derivatives, two-dimensional sheet and layer structures were formed through pi...pi, multiple S...S interactions, and complementary double hydrogen bonds.	Hydrogen	170-178	ras homolog family member H	Homo sapiens	27-30
23660814-5	2013	The residues Ala 354, Glu 376, Asp 377, Glu 384, His 513, Tyr 520 and Tyr 523 of tACE stabilized lisinopril by hydrogen bonding interactions.	Hydrogen	111-119	ADAM metallopeptidase domain 17	Homo sapiens	81-85
16818232-4	2006	Specific hydrogen bonds between U2AF(65) and the uracil bases provide an explanation for polyuridine recognition.	Hydrogen	9-17	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	32-40
23742482-1	2013	Spin-orbit (de-)excitation of C(+)((2)P) by collisions with H2, a key process for astrochemistry, is investigated.	Hydrogen	60-62	spindlin 1	Homo sapiens	0-4
16712900-7	2006	When the yeast amount is low, the added glucose is more efficiently used by the enzymes as electron donor and its hydrogen atoms bound to C-1 and C-3 are delivered to the substrate.	Hydrogen	114-122	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	138-149
23695836-8	2013	Strain CAB utilized a variety of organic acids, fructose, and hydrogen as electron donors coupled to (per)chlorate reduction.	Hydrogen	62-70	neural proliferation, differentiation and control 1	Homo sapiens	7-10
16774340-3	2006	The global minimum with De=1565 cm(-1) and Re=7.47a0 has a linear HCN-HCl hydrogen-bonded structure with HCl as the donor.	Hydrogen	74-82	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	66-69
23657349-3	2013	Radio observations of the Local Group of galaxies have revealed hydrogen gas extending from the disk of the galaxy M31 at least halfway to M33.	Hydrogen	64-72	chromobox 1	Homo sapiens	115-118
23657349-3	2013	Radio observations of the Local Group of galaxies have revealed hydrogen gas extending from the disk of the galaxy M31 at least halfway to M33.	Hydrogen	64-72	chromobox 2	Homo sapiens	139-142
23483409-7	2013	Three of them were found to form hydrogen bonds with the catalytic site of the DNMT1 (Cys 1226).	Hydrogen	33-41	DNA methyltransferase 1	Homo sapiens	79-84
16774340-4	2006	A secondary hydrogen-bonded equilibrium structure with De=564 cm(-1) and Re=8.21a0 has a T-shaped geometry with HCN as the donor and the acceptor HCl molecule nearly perpendicular to the intermolecular axis.	Hydrogen	12-20	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	112-115
16616004-2	2006	Our new model suggests three key interactions such that (1) a protonated nitrogen of the channel blocker forms a hydrogen bond with the carbonyl oxygen of HERG residue T623; (2) an aromatic moiety of the channel blocker makes a pi-pi interaction with the aromatic ring of HERG residue Y652; and (3) a hydrophobic group of the channel blocker forms a hydrophobic interaction with the benzene ring of HERG residue F656.	Hydrogen	113-121	potassium voltage-gated channel subfamily H member 2	Homo sapiens	155-159
23388512-13	2013	Hydrogen treatment diminished phosphorylation of Lyn kinase and release of tryptase, decreased accumulation and degranulation of mast cells, attenuated blood-brain barrier disruption, and improved neurobehavioral function.	Hydrogen	0-8	LYN proto-oncogene, Src family tyrosine kinase	Mus musculus	49-52
23485143-2	2013	The structures of the PhA1,2,3 clusters are dominated by phenol-acetylene pi-hydrogen bonds whereas Ph2A1 binds via OH   OH   C C interaction with dominating Ph-Ph hydrogen bond like in the phenol dimer and acetylene attached to the free OH group of the proton acceptor phenol.	Hydrogen	77-85	sodium channel epithelial 1 subunit gamma	Homo sapiens	22-26
23485143-2	2013	The structures of the PhA1,2,3 clusters are dominated by phenol-acetylene pi-hydrogen bonds whereas Ph2A1 binds via OH   OH   C C interaction with dominating Ph-Ph hydrogen bond like in the phenol dimer and acetylene attached to the free OH group of the proton acceptor phenol.	Hydrogen	164-172	sodium channel epithelial 1 subunit gamma	Homo sapiens	22-26
16616004-2	2006	Our new model suggests three key interactions such that (1) a protonated nitrogen of the channel blocker forms a hydrogen bond with the carbonyl oxygen of HERG residue T623; (2) an aromatic moiety of the channel blocker makes a pi-pi interaction with the aromatic ring of HERG residue Y652; and (3) a hydrophobic group of the channel blocker forms a hydrophobic interaction with the benzene ring of HERG residue F656.	Hydrogen	113-121	potassium voltage-gated channel subfamily H member 2	Homo sapiens	272-276
16616004-2	2006	Our new model suggests three key interactions such that (1) a protonated nitrogen of the channel blocker forms a hydrogen bond with the carbonyl oxygen of HERG residue T623; (2) an aromatic moiety of the channel blocker makes a pi-pi interaction with the aromatic ring of HERG residue Y652; and (3) a hydrophobic group of the channel blocker forms a hydrophobic interaction with the benzene ring of HERG residue F656.	Hydrogen	113-121	potassium voltage-gated channel subfamily H member 2	Homo sapiens	272-276
16500955-2	2006	We have applied a systematic analysis of hydrogen bonding patterns in 11 prokaryotic and mammalian CYP crystal structures to construct a homology-based model of CYP27A1.	Hydrogen	41-49	peptidylprolyl isomerase G	Homo sapiens	99-102
23404844-7	2013	In addition we show that the heteromolecular H2 S-MeOH complex, for which both S-H   O and O-H   S interactions are possible, is S-H   O bound.	Hydrogen	45-47	shadow of prion protein	Homo sapiens	79-92
16500955-2	2006	We have applied a systematic analysis of hydrogen bonding patterns in 11 prokaryotic and mammalian CYP crystal structures to construct a homology-based model of CYP27A1.	Hydrogen	41-49	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	161-168
16330245-0	2006	A theoretical study of hydrogen complexes of the XH-pi type between propyne and HF, HCL or HCN.	Hydrogen	23-31	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	91-94
23363739-5	2013	Docking models composed of NEU2 and the thiosialyloligosaccharide suggested that the active pocket of NEU2 prefers the second galactose-beta (Galbeta) to the glucose-beta (Glcbeta) residue in the trisaccharide structure, there being a hydrogen bond between the 4-hydroxy group of the second Galbeta and the side chain of the D46 residue of NEU2.	Hydrogen	235-243	neuraminidase 2	Homo sapiens	27-31
23363739-5	2013	Docking models composed of NEU2 and the thiosialyloligosaccharide suggested that the active pocket of NEU2 prefers the second galactose-beta (Galbeta) to the glucose-beta (Glcbeta) residue in the trisaccharide structure, there being a hydrogen bond between the 4-hydroxy group of the second Galbeta and the side chain of the D46 residue of NEU2.	Hydrogen	235-243	neuraminidase 2	Homo sapiens	102-106
23363739-5	2013	Docking models composed of NEU2 and the thiosialyloligosaccharide suggested that the active pocket of NEU2 prefers the second galactose-beta (Galbeta) to the glucose-beta (Glcbeta) residue in the trisaccharide structure, there being a hydrogen bond between the 4-hydroxy group of the second Galbeta and the side chain of the D46 residue of NEU2.	Hydrogen	235-243	neuraminidase 2	Homo sapiens	102-106
23511424-1	2013	The development of an efficient catalytic process that mimics the enzymatic function of alcohol dehydrogenase is critical for using biomass alcohols for both the production of H2 as a chemical energy carrier and fine chemicals under waste-free conditions.	Hydrogen	176-178	aldo-keto reductase family 1 member A1	Homo sapiens	88-109
23375358-7	2013	A maximum increase in c-fos and c-jun protein expression in response to IL-delta was observed 1h after initiation of the treatment.	Hydrogen	94-96	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	22-27
23375358-7	2013	A maximum increase in c-fos and c-jun protein expression in response to IL-delta was observed 1h after initiation of the treatment.	Hydrogen	94-96	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	32-37
16671664-1	2006	The initiation of the hydrogen exchange reaction Cl((2)P)+HCl --&gt; ClH+Cl((2)P) by excitation of the HCl molecular stretch to v=2 is studied for total angular momentum quantum number J=(1)/(2) and both even and odd parity.	Hydrogen	22-30	T cell receptor gamma variable 9	Homo sapiens	128-131
23303461-3	2013	It has been demonstrated that the CYP2A6-catalyzed N-methylhydroxylation reaction is a concerted process involving a hydrogen-transfer transition state on both the quartet and the doublet states.	Hydrogen	117-125	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	34-40
16671666-1	2006	The possible competition of Z/E versus hydrogen-shift isomerization in (E)-5-phenyl-3-penten-2-one (E-1) and (E)-5-phenyl-4-penten-2-one (E-2) was studied, both experimentally and theoretically.	Hydrogen	39-47	small nucleolar RNA, H/ACA box 73A	Homo sapiens	100-103
16704205-5	2006	The Lac-PEG-PSAO-PAMA spontaneously associated with plasmid DNA (pDNA) to form three-layered polyplex micelles with a PAMA/pDNA polyion complex (PIC) core, an uncomplexed PSAO inner shell, and a lactosylated PEG outer shell, as confirmed by 1H NMR spectroscopy.	Hydrogen	241-243	progestagen associated endometrial protein	Homo sapiens	8-11
23352754-4	2013	A molecular docking within the active site of some CA isoforms, such as hCA I, explained these findings, as the benzenedisulfonimide moiety makes favorable interactions (hydrogen bonds) with amino acid residues involved in binding of inhibitors, such as Gln92, His67, and His64.	Hydrogen	170-178	carbonic anhydrase 1	Homo sapiens	72-77
16515860-0	2006	Low-resolution 1H spin-spin relaxation of n-decane/water emulsions stabilized by beta-casein.	Hydrogen	15-17	casein beta	Homo sapiens	81-92
23361354-6	2013	The change from distilled water to tap or simulated sea water results in a lower hydrogen evolution rate of about 50%.	Hydrogen	81-89	nuclear RNA export factor 1	Homo sapiens	35-38
16515860-1	2006	A low-resolution 1H NMR relaxometry study on the dynamics of an n-decane/water emulsion stabilized by beta-casein is presented.	Hydrogen	17-19	casein beta	Homo sapiens	102-113
23387303-3	2013	Such an interdigitated hydrogen bond donor-acceptor (HBD-HBA) array imposes significant energy barriers (DeltaG( ) = 10-16 kcal mol(-1)) for internal bond rotations to assist structural preorganization and effectively polarizes the electrophilic carbonyl group toward a nucleophilic attack by CN(-) in aqueous environment.	Hydrogen	23-31	HBD	Homo sapiens	53-56
16522124-0	2006	Insights into the hydrogen-abstraction reactions of diol dehydratase: relevance to the catalytic mechanism and suicide inactivation.	Hydrogen	18-26	aldo-keto reductase family 1 member C1	Homo sapiens	52-68
16522124-1	2006	High-level quantum chemistry calculations have been used to examine the hydrogen-abstraction reactions of diol dehydratase (DDH) in the context of both the catalytic mechanism and the enzyme dysfunction phenomenon termed suicide inactivation.	Hydrogen	72-80	aldo-keto reductase family 1 member C1	Homo sapiens	106-122
23448168-11	2013	The interaction between SCN(-) ions and DMAA repeat units is argued to block hydrogen bonds between DMAA and water molecules.	Hydrogen	77-85	sorcin	Homo sapiens	24-27
16509583-7	2006	A related docking study of 13e in the 15-LOX binding site indicates that the C-3 p-SO2Me COX-2 pharmacophore was positioned in a region closer to the catalytic iron site where it undergoes a hydrogen bonding interaction with His541 and His366, and that the C-1 p-i-Pr substituent is buried deep in a hydrophobic pocket (Ile414, Ile418, Met419 and Ile593) near the base of the 15-LOX binding site.	Hydrogen	191-199	arachidonate 15-lipoxygenase	Rattus norvegicus	38-44
16266835-7	2006	Complementary studies with Cd2+ ions cause perturbations to 1H NMR spectra that are strikingly similar to that observed for Zn2+.	Hydrogen	60-62	CD2 molecule	Homo sapiens	27-30
23252792-9	2013	Furthermore, hydrogen-rich saline reduced oxidative stress, increased antioxidant enzyme activities and preserved synaptophysin and BDNF levels in the diabetic rat retina.	Hydrogen	13-21	synaptophysin	Rattus norvegicus	114-127
23252792-9	2013	Furthermore, hydrogen-rich saline reduced oxidative stress, increased antioxidant enzyme activities and preserved synaptophysin and BDNF levels in the diabetic rat retina.	Hydrogen	13-21	brain-derived neurotrophic factor	Rattus norvegicus	132-136
16299777-4	2006	However, the functional specificities of these domains could be due to the dynamics of the individual amino acid residues, as has been shown earlier in the case of backbone dynamics of 15N-1H of dsRNA binding motifs (dsRBMs) of human protein kinase R (PKR) (Nanduri S, Rahman F, Williams BRG, Qin J. EMBO J 2000;19:5567-5574).	Hydrogen	189-191	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	234-250
23643085-0	2013	[Effect of AKR1A1 knock-down on H2;O2; and 4-hydroxynonenal-induced cytotoxicity in human 1321N1 astrocytoma cells].	Hydrogen	32-34	aldo-keto reductase family 1 member A1	Homo sapiens	11-17
23643085-4	2013	MTT assay was used to examine the cell viability after H2;O2; and 4-hydroxynonenal treatment in AKR1A1 knock-down cells.	Hydrogen	55-57	aldo-keto reductase family 1 member A1	Homo sapiens	96-102
23643085-7	2013	Cells with knock-down of AKR1A1 were more sensitive to H2;O2; and 4-hydroxynonenal-induced cytotoxicity.	Hydrogen	55-57	aldo-keto reductase family 1 member A1	Homo sapiens	25-31
23643085-8	2013	Furthermore, cellular ROS level in the cells with knock-down of AKR1A1 was much higher than that in the control cells in the presence of H2;O2;.	Hydrogen	137-139	aldo-keto reductase family 1 member A1	Homo sapiens	64-70
16299777-4	2006	However, the functional specificities of these domains could be due to the dynamics of the individual amino acid residues, as has been shown earlier in the case of backbone dynamics of 15N-1H of dsRNA binding motifs (dsRBMs) of human protein kinase R (PKR) (Nanduri S, Rahman F, Williams BRG, Qin J. EMBO J 2000;19:5567-5574).	Hydrogen	189-191	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	252-255
16373509-1	2006	Molecular tips in scanning tunneling microscopy can directly detect intermolecular electron tunneling between sample and tip molecules and reveal the tunneling facilitation through chemical interactions that provide overlap of respective electronic wave functions, that is, hydrogen-bond, metal-coordination-bond, and charge-transfer interactions.	Hydrogen	274-282	TOR signaling pathway regulator	Homo sapiens	10-13
23303174-3	2013	Specifically, although the natural pyrimidines preferentially adopt the anti orientation with respect to the 2"-deoxyribose moiety, the expanded analogues will likely display (anti/syn) conformational heterogeneity, which may lead to alternate hydrogen-bonding modes in double-stranded duplexes.	Hydrogen	244-252	synemin	Homo sapiens	181-184
23320793-5	2013	These findings may prove to be instrumental in future design of MoS(2)-based electronics, as well as in exploring novel catalysts for hydrogen production and related chemical processes.	Hydrogen	134-142	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	64-67
17168729-4	2006	Two evidences playing important roles for the inhibition by the active compounds, are 1) C-1 and C-3" hydroxyl groups formed hydrogen bonds with COX-2/COX-1 Val523/Ile523 and Arg120, respectively, 2) hydrogen at C-5 of the naphthalene nucleus was attracted rather close to the phenolic group of Tyr385 due to van der Waals interaction.	Hydrogen	125-133	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	89-100
17168729-4	2006	Two evidences playing important roles for the inhibition by the active compounds, are 1) C-1 and C-3" hydroxyl groups formed hydrogen bonds with COX-2/COX-1 Val523/Ile523 and Arg120, respectively, 2) hydrogen at C-5 of the naphthalene nucleus was attracted rather close to the phenolic group of Tyr385 due to van der Waals interaction.	Hydrogen	125-133	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	151-156
17168729-4	2006	Two evidences playing important roles for the inhibition by the active compounds, are 1) C-1 and C-3" hydroxyl groups formed hydrogen bonds with COX-2/COX-1 Val523/Ile523 and Arg120, respectively, 2) hydrogen at C-5 of the naphthalene nucleus was attracted rather close to the phenolic group of Tyr385 due to van der Waals interaction.	Hydrogen	200-208	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	89-100
23117207-7	2013	Keap1 is expressed in differentiating osteoclast-like cells and the S349T mutation selectively impairs the SQSTM1-Keap1 interaction in co-immunoprecipitations, which molecular modelling indicates results from effects on critical hydrogen bonds required to stabilise the KIR-Keap1 complex.	Hydrogen	229-237	sequestosome 1	Homo sapiens	107-113
17168729-4	2006	Two evidences playing important roles for the inhibition by the active compounds, are 1) C-1 and C-3" hydroxyl groups formed hydrogen bonds with COX-2/COX-1 Val523/Ile523 and Arg120, respectively, 2) hydrogen at C-5 of the naphthalene nucleus was attracted rather close to the phenolic group of Tyr385 due to van der Waals interaction.	Hydrogen	200-208	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	151-156
23275167-8	2013	Additionally, the various hydrogen bonds formed between the AHNAK peptide and (p11)(2)(AnxA2)(2) most often involve backbone atoms of AHNAK; as a result, the side chains, particularly those that point away from S100A10/AnxA2 towards the solvent, are largely interchangeable.	Hydrogen	26-34	AHNAK nucleoprotein	Homo sapiens	60-65
16165251-8	2006	Ser phosphorylation allows electrostatic interaction and hydrogen bond with the amino acids of the beta-TrCP binding pocket.	Hydrogen	57-65	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	99-108
23275167-8	2013	Additionally, the various hydrogen bonds formed between the AHNAK peptide and (p11)(2)(AnxA2)(2) most often involve backbone atoms of AHNAK; as a result, the side chains, particularly those that point away from S100A10/AnxA2 towards the solvent, are largely interchangeable.	Hydrogen	26-34	AHNAK nucleoprotein	Homo sapiens	134-139
22260360-7	2013	This hydrophobic interaction is further stabilized by hydrogen bonding via hydroxyl/oxo groups of EGCG to PP1c residues.	Hydrogen	54-62	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	106-110
23646697-0	2013	Inhibitions by hydrogen-occluding silica microcluster to melanogenesis in human pigment cells and tyrosinase reaction.	Hydrogen	15-23	tyrosinase	Homo sapiens	98-108
23646697-1	2013	We investigated the anti-melanogenetic efficacy of hydrogen-occluding silica microcluster (H2-Silica), which is a silsesquioxane-based compound with hydrogen interstitially embedded in a matrix of caged silica, against melanogenesis in HMV-II human melanoma cells and L-DOPA-tyrosinase reaction [EC1.14.18.1].	Hydrogen	51-59	tyrosinase	Homo sapiens	275-285
23646697-9	2013	The enzymatic assay using L-DOPA and mushroom tyrosinase demonstrated that H2-Silica restrained UVA-mediated melanin formation owing to down-regulation of tyrosinase activity, which could be attributed to scavenging of free radicals and inhibition of L-DOPA-to-dopachrome oxidation by hydrogen released from H2-Silica.	Hydrogen	285-293	tyrosinase	Homo sapiens	46-56
23646697-9	2013	The enzymatic assay using L-DOPA and mushroom tyrosinase demonstrated that H2-Silica restrained UVA-mediated melanin formation owing to down-regulation of tyrosinase activity, which could be attributed to scavenging of free radicals and inhibition of L-DOPA-to-dopachrome oxidation by hydrogen released from H2-Silica.	Hydrogen	285-293	tyrosinase	Homo sapiens	155-165
23646697-9	2013	The enzymatic assay using L-DOPA and mushroom tyrosinase demonstrated that H2-Silica restrained UVA-mediated melanin formation owing to down-regulation of tyrosinase activity, which could be attributed to scavenging of free radicals and inhibition of L-DOPA-to-dopachrome oxidation by hydrogen released from H2-Silica.	Hydrogen	75-77	tyrosinase	Homo sapiens	46-56
23646697-9	2013	The enzymatic assay using L-DOPA and mushroom tyrosinase demonstrated that H2-Silica restrained UVA-mediated melanin formation owing to down-regulation of tyrosinase activity, which could be attributed to scavenging of free radicals and inhibition of L-DOPA-to-dopachrome oxidation by hydrogen released from H2-Silica.	Hydrogen	75-77	tyrosinase	Homo sapiens	155-165
23468611-3	2013	These disease-causing missense mutations were demonstrated, both in silico and in vitro, to affect the wild type function of SMS by either destabilizing the SMS dimer/monomer or directly affecting the hydrogen bond network of the active site of SMS.	Hydrogen	201-209	spermine synthase	Homo sapiens	125-128
23408980-0	2013	Quantitative 1H-NMR-metabolomics reveals extensive metabolic reprogramming and the effect of the aquaglyceroporin FPS1 in ethanol-stressed yeast cells.	Hydrogen	13-15	Fps1p	Saccharomyces cerevisiae S288C	114-118
23459307-2	2013	We propose a new spin caloritronics device based on zigzag graphene nanoribbon (ZGNR), which is a heterojunction consisting of single-hydrogen-terminated ZGNR (ZGNR-H) and double-hydrogen-terminated ZGNR (ZGNR-H2).	Hydrogen	134-142	spindlin 1	Homo sapiens	17-21
23459307-2	2013	We propose a new spin caloritronics device based on zigzag graphene nanoribbon (ZGNR), which is a heterojunction consisting of single-hydrogen-terminated ZGNR (ZGNR-H) and double-hydrogen-terminated ZGNR (ZGNR-H2).	Hydrogen	179-187	spindlin 1	Homo sapiens	17-21
24171321-4	2013	Recently, we proposed that electrons travel from the haem edge of cytochrome c to CuA, the first metal redox centre of COX, by a hydrogen/hydride ion relay using six residues.	Hydrogen	129-137	cytochrome c oxidase subunit 7A1	Bos taurus	119-122
23140279-2	2012	FTIR-ATR measurements reveal two types of interaction of PAM with MNPs: hydrogen bonding and inner-sphere metal-carboxylate complex formation.	Hydrogen	72-80	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	57-60
22959971-3	2012	Based on the structure of a yeast polyamine oxidase, Saccharomyces cerevisiae Fms1, this residue has been proposed to hydrogen bond to the reactive nitrogen in the polyamine substrate.	Hydrogen	118-126	polyamine oxidase	Saccharomyces cerevisiae S288C	34-51
22959971-3	2012	Based on the structure of a yeast polyamine oxidase, Saccharomyces cerevisiae Fms1, this residue has been proposed to hydrogen bond to the reactive nitrogen in the polyamine substrate.	Hydrogen	118-126	polyamine oxidase	Saccharomyces cerevisiae S288C	78-82
22842019-4	2012	DCMU addition to Nda2-deficient cells completely inhibited H2 photoproduction, showing that the PSII-independent H2 photoproduction relies on the presence of Nda2, which feeds the photosynthetic electron transport chain with electrons derived from oxidative catabolism.	Hydrogen	59-61	uncharacterized protein	Chlamydomonas reinhardtii	17-21
22842019-4	2012	DCMU addition to Nda2-deficient cells completely inhibited H2 photoproduction, showing that the PSII-independent H2 photoproduction relies on the presence of Nda2, which feeds the photosynthetic electron transport chain with electrons derived from oxidative catabolism.	Hydrogen	59-61	uncharacterized protein	Chlamydomonas reinhardtii	158-162
22842019-4	2012	DCMU addition to Nda2-deficient cells completely inhibited H2 photoproduction, showing that the PSII-independent H2 photoproduction relies on the presence of Nda2, which feeds the photosynthetic electron transport chain with electrons derived from oxidative catabolism.	Hydrogen	113-115	uncharacterized protein	Chlamydomonas reinhardtii	17-21
22842019-4	2012	DCMU addition to Nda2-deficient cells completely inhibited H2 photoproduction, showing that the PSII-independent H2 photoproduction relies on the presence of Nda2, which feeds the photosynthetic electron transport chain with electrons derived from oxidative catabolism.	Hydrogen	113-115	uncharacterized protein	Chlamydomonas reinhardtii	158-162
22842019-5	2012	Nda2-protein abundance increased as a result of sulphur deprivation and further during the H2 photoproduction process, resulting in high rates of non-photochemical plastoquinone reduction in control cells.	Hydrogen	91-93	uncharacterized protein	Chlamydomonas reinhardtii	0-4
22842019-7	2012	The rapid decline of H2 photoevolution rate with time in Nda2-deficient cells revealed a more pronounced inhibition of H2 photoproduction by accumulated H2 in the absence of non-photochemical plastoquinone reduction.	Hydrogen	21-23	uncharacterized protein	Chlamydomonas reinhardtii	57-61
22842019-7	2012	The rapid decline of H2 photoevolution rate with time in Nda2-deficient cells revealed a more pronounced inhibition of H2 photoproduction by accumulated H2 in the absence of non-photochemical plastoquinone reduction.	Hydrogen	119-121	uncharacterized protein	Chlamydomonas reinhardtii	57-61
22842019-7	2012	The rapid decline of H2 photoevolution rate with time in Nda2-deficient cells revealed a more pronounced inhibition of H2 photoproduction by accumulated H2 in the absence of non-photochemical plastoquinone reduction.	Hydrogen	119-121	uncharacterized protein	Chlamydomonas reinhardtii	57-61
22842019-8	2012	Nda2 is therefore important for linking H2 photoproduction with catabolism of storage carbon compounds, and seems also involved in regulating the redox poise of the photosynthetic electron transport chain during H2 photoproduction.	Hydrogen	40-42	uncharacterized protein	Chlamydomonas reinhardtii	0-4
22842019-8	2012	Nda2 is therefore important for linking H2 photoproduction with catabolism of storage carbon compounds, and seems also involved in regulating the redox poise of the photosynthetic electron transport chain during H2 photoproduction.	Hydrogen	212-214	uncharacterized protein	Chlamydomonas reinhardtii	0-4
26605629-5	2012	The translational and rotational motions of the protein-bound spin label are considerably slowed compared to those of the free spin label in aqueous solution, but interestingly, hydrogen bonds formed between the nitroxide oxygen group and the surrounding water molecules are hardly affected by the presence of the amyloid protein.	Hydrogen	178-186	spindlin 1	Homo sapiens	62-66
23007395-2	2012	This modification does not affect the interaction of p27 with cyclin-CDK complexes but does interfere with van der Waals and hydrogen bond contacts between p27 and amino acids in the catalytic cleft of the CDK.	Hydrogen	125-133	cyclin-dependent kinase inhibitor 1B	Mus musculus	156-159
26296009-6	2012	The suggested approach to accounting for hydrogen bond formation within the general DPD framework may make the DPD method a competitive alternative to CGMD for modeling equilibrium and dynamic properties of proteins and polypeptides, especially during their transport in confined environments.	Hydrogen	41-49	dihydropyrimidine dehydrogenase	Homo sapiens	84-87
26296009-6	2012	The suggested approach to accounting for hydrogen bond formation within the general DPD framework may make the DPD method a competitive alternative to CGMD for modeling equilibrium and dynamic properties of proteins and polypeptides, especially during their transport in confined environments.	Hydrogen	41-49	dihydropyrimidine dehydrogenase	Homo sapiens	111-114
23032298-1	2012	The hydrogen-methane compound (H(2))(4)CH(4)-or for short H4M-is one of the most promising hydrogen-storage materials.	Hydrogen	4-12	H4 clustered histone 9	Homo sapiens	58-61
23032298-1	2012	The hydrogen-methane compound (H(2))(4)CH(4)-or for short H4M-is one of the most promising hydrogen-storage materials.	Hydrogen	91-99	H4 clustered histone 9	Homo sapiens	58-61
23032298-7	2012	On the other hand, we find that all the investigated carbon nanotubes can create the high pressures required for H4M to be stable at room temperature, with direct implications for new and exciting hydrogen-storage applications.	Hydrogen	197-205	H4 clustered histone 9	Homo sapiens	113-116
23039896-1	2012	To explore the relationships between denitrifying bacteria (DB) and sulfate-reducing bacteria (SRB) in H(2)-fed biofilms, we used two H(2)-based membrane biofilm reactors (MBfRs) with or without restrictions on H(2) availability.	Hydrogen	103-107	chaperonin containing TCP1 subunit 4	Homo sapiens	95-98
23039896-2	2012	DB and SRB compete for H(2) and space in the biofilm, and sulfate (SO(4)(2-)) reduction should be out-competed when H(2) is limiting inside the biofilm.	Hydrogen	23-27	chaperonin containing TCP1 subunit 4	Homo sapiens	7-10
23039896-8	2012	In all scenarios tested, the SRB were able to initiate strong SO(4)(2-) reduction only when competition for H(2) inside the biofilm was relieved by nearly complete removal of NO(3)(-).	Hydrogen	108-112	chaperonin containing TCP1 subunit 4	Homo sapiens	29-32
22930071-5	2012	Relatively small substituents incorporating a hydrogen-bonding donor, i.e., NHAc and NHMs, were effective for eliciting VDR transcriptional activity, and 2beta-NHMs-1,25-VD(3) () showed the highest activity, being more potent than 1,25-VD(3).	Hydrogen	46-54	vitamin D receptor	Homo sapiens	120-123
16288482-0	2006	Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase.	Hydrogen	22-30	butyrylcholinesterase	Homo sapiens	134-155
16288482-3	2006	During BChE-catalyzed hydrolysis of cocaine, only G117 has a hydrogen bond with the carbonyl oxygen (O31) of the cocaine benzoyl ester in the prereactive BChE-cocaine complex, and the NH groups of G117 and A199 are hydrogen-bonded with O31 of cocaine in all of the transition states and intermediates.	Hydrogen	61-69	butyrylcholinesterase	Homo sapiens	7-11
16288482-3	2006	During BChE-catalyzed hydrolysis of cocaine, only G117 has a hydrogen bond with the carbonyl oxygen (O31) of the cocaine benzoyl ester in the prereactive BChE-cocaine complex, and the NH groups of G117 and A199 are hydrogen-bonded with O31 of cocaine in all of the transition states and intermediates.	Hydrogen	61-69	butyrylcholinesterase	Homo sapiens	154-158
16288482-3	2006	During BChE-catalyzed hydrolysis of cocaine, only G117 has a hydrogen bond with the carbonyl oxygen (O31) of the cocaine benzoyl ester in the prereactive BChE-cocaine complex, and the NH groups of G117 and A199 are hydrogen-bonded with O31 of cocaine in all of the transition states and intermediates.	Hydrogen	215-223	butyrylcholinesterase	Homo sapiens	7-11
16288482-6	2006	The change of the estimated hydrogen-bonding energy between the oxyanion hole and O31 of cocaine during the reaction process demonstrates how the protein environment can affect the energy barrier for each step of the BChE-catalyzed hydrolysis of cocaine.	Hydrogen	28-36	butyrylcholinesterase	Homo sapiens	217-221
23061865-5	2012	In contrary, the denaturation of hairpin structure of GB1p peptide in GdmSCN/water solution is induced by the accumulation of Gdm(+) on protein surface and the hydrogen bonding from water as well as Gdm(+).	Hydrogen	160-168	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	54-58
16515461-7	2006	Structure analysis using Swiss Deep Viewer v3.7 has indicated that Arg in place of Lys12 may eliminate AdoMetDC activity by restricting the mobility of Thr85 through hydrogen bonding.	Hydrogen	166-174	adenosylmethionine decarboxylase 1	Homo sapiens	103-111
23351427-3	2012	Our purpose is to study the prophylactic effect of HS 5% infusion versus NS on serum IL-6 as an inflammatory &amp; IL-10 as an anti-inflammatory biomarker in CABG patients.	Hydrogen	51-53	interleukin 10	Homo sapiens	115-120
16279779-3	2005	Pro-1 was discovered to form a bifurcated hydrogen bond between its protonated nitrogen and carboxylate oxygens of E-ligands and Tyr-36.	Hydrogen	42-50	lamin A/C	Homo sapiens	0-5
22244830-9	2012	The structural analysis also revealed the potential binding mode of SU6656 to the ATP-binding cleft of Aurora B via four hydrogen bonds.	Hydrogen	121-129	aurora kinase B	Homo sapiens	103-111
22949663-9	2012	Steered by nonspecific electrostatic, hydrophobic, and specific hydrogen-bonding interactions, Gd@C(82)(OH)(22) exhibits specific binding modes near the ligand-specificity loop S1", thereby inhibiting MMP-9 activity.	Hydrogen	64-72	matrix metallopeptidase 9	Homo sapiens	201-206
16248648-2	2005	The PPh(3) and AsPh(3) complexes clearly contain one dihydrogen ligand and two terminal hydrides; the H(2) ligand is transoid to the Lewis base, and the H-H vector connecting the central two hydrogen atoms lies parallel to the Ct-Os-L plane (Ct = centroid of Cp* ring).	Hydrogen	55-63	aspartate beta-hydroxylase	Homo sapiens	15-19
22771631-6	2012	A molecular-docking study carried out using the experimentally-derived X-ray crystal structure of MMP-12 (PDB ID: 3F17) revealed critical hydrogen bonding of the hydroxamate and the sulfonamide moieties with key active site residues.	Hydrogen	138-146	matrix metallopeptidase 12	Homo sapiens	98-104
16267026-17	2005	Molecular modeling studies also showed that due to increased hydrogen bonding between the hydroquinone and the Hsp90 protein, 17-AAGH2 was bound more tightly to the ATP-binding site in both yeast and human Hsp90 models.	Hydrogen	61-69	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	111-116
22897320-4	2012	In this work we characterize conformational and dynamic changes in ferrochelatase associated with porphyrin binding using the substrate mesoporphyrin (MPIX) and backbone amide hydrogen/deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	176-184	ferrochelatase	Homo sapiens	67-81
22902635-7	2012	The intracellular surfactant pool, tissue adenosine triphosphate (ATP) levels and heat shock protein 70 (HSP70) expression increased in the hydrogen-treated grafts.	Hydrogen	140-148	heat shock protein family A (Hsp70) member 4	Homo sapiens	82-103
22902635-7	2012	The intracellular surfactant pool, tissue adenosine triphosphate (ATP) levels and heat shock protein 70 (HSP70) expression increased in the hydrogen-treated grafts.	Hydrogen	140-148	heat shock protein family A (Hsp70) member 4	Homo sapiens	105-110
22742936-6	2012	In addition, treatment with hydrogen-rich saline, which elevated the levels of molecules associated with brain-derived neurotropic factor (BDNF)-mediated synaptic plasticity, improved cognitive performance in the Morris water maze after mild TBI.	Hydrogen	28-36	brain derived neurotrophic factor	Homo sapiens	105-137
22742936-6	2012	In addition, treatment with hydrogen-rich saline, which elevated the levels of molecules associated with brain-derived neurotropic factor (BDNF)-mediated synaptic plasticity, improved cognitive performance in the Morris water maze after mild TBI.	Hydrogen	28-36	brain derived neurotrophic factor	Homo sapiens	139-143
22458729-6	2012	In cytoplasmic membranes reduction of CymA may then require the thermodynamic driving force from NADH, formate or H2 oxidation as the redox poise of the menaquinol pool in isolation is insufficient.	Hydrogen	114-116	cytochrome c	Shewanella oneidensis MR-1	38-42
21783618-7	2005	Exposure of NK cells to DBT for 1h caused significant decreases in the mRNAs for granzyme B and perforin but not in protein levels.	Hydrogen	32-34	granzyme B	Homo sapiens	81-91
22116613-7	2012	Additionally, more hydrogen bonds were formed in the closed state than in the open state of FXa, which is believed to play a significant role in maintaining the closed confirmation of the aryl-binding site.	Hydrogen	19-27	coagulation factor X	Homo sapiens	92-95
16257689-0	2005	1,3-Diaxial steric effects and intramolecular hydrogen bonding in the conformational equilibria of new cis-1,3-disubstituted cyclohexanes using low temperature NMR spectra and theoretical calculations.	Hydrogen	46-54	suppressor of cytokine signaling 1	Homo sapiens	103-108
22554903-5	2012	c-Fos in the PVN and SO nuclei was found to be significantly increased in trained rats 1h post-exercise compared with control and 24h post-exercise groups.	Hydrogen	87-89	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
16257689-3	2005	H-1 and H-3 hydrogen vicinal coupling constants and DeltaG(J)(av) values showed that the diequatorial conformer is predominant in the conformational equilibrium of the compounds studied at low temperature.	Hydrogen	12-20	H1.5 linker histone, cluster member	Homo sapiens	0-11
16223878-1	2005	The structure of alpha-synuclein (alpha-syn) amyloid was studied by hydrogen-deuterium exchange by using a fragment separation-MS analysis.	Hydrogen	68-76	synuclein alpha	Homo sapiens	17-32
22568562-0	2012	Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures.	Hydrogen	40-48	aldo-keto reductase family 1 member A1	Homo sapiens	89-110
16223878-1	2005	The structure of alpha-synuclein (alpha-syn) amyloid was studied by hydrogen-deuterium exchange by using a fragment separation-MS analysis.	Hydrogen	68-76	synuclein alpha	Homo sapiens	17-26
22387465-2	2012	Three truncated Escherichia coli Lon (ELon) mutants were generated based on a previous limited tryptic digestion result and hydrogen-deuterium exchange mass spectrometry analyses performed in this study.	Hydrogen	124-132	putative ATP-dependent Lon protease	Escherichia coli	33-36
16223878-3	2005	The soluble alpha-syn monomer exchanges its amide hydrogens with water hydrogens at random coil rates, consistent with its natively unstructured condition.	Hydrogen	50-59	synuclein alpha	Homo sapiens	12-21
16223878-3	2005	The soluble alpha-syn monomer exchanges its amide hydrogens with water hydrogens at random coil rates, consistent with its natively unstructured condition.	Hydrogen	71-80	synuclein alpha	Homo sapiens	12-21
16129418-4	2005	The complex structure indicates the essentiality of the two nitro groups: one nitro group forms hydrogen bonds with the side-chain of Asn161 of QR2 to hold the other nitro group in position for the reduction.	Hydrogen	96-104	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	144-147
22506583-8	2012	This implies the presence of void volumes within structural defects in racemic aggregates, preventing the precise alignment of main and side chains necessary to zip up ladders of bifurcated hydrogen bonds.	Hydrogen	190-198	death associated protein kinase 3	Homo sapiens	161-164
22873060-1	2012	The kinetics of hydrogen exchange of pike a-parvalbumin was investigated using the method of infrared spectroscopy (sensitive to the amide hydrogen atoms in the peptide) and radioisotope method (sensitive to all labile hydrogen atoms).	Hydrogen	16-24	parvalbumin	Homo sapiens	44-55
22873060-1	2012	The kinetics of hydrogen exchange of pike a-parvalbumin was investigated using the method of infrared spectroscopy (sensitive to the amide hydrogen atoms in the peptide) and radioisotope method (sensitive to all labile hydrogen atoms).	Hydrogen	139-147	parvalbumin	Homo sapiens	44-55
22873060-1	2012	The kinetics of hydrogen exchange of pike a-parvalbumin was investigated using the method of infrared spectroscopy (sensitive to the amide hydrogen atoms in the peptide) and radioisotope method (sensitive to all labile hydrogen atoms).	Hydrogen	139-147	parvalbumin	Homo sapiens	44-55
22873060-3	2012	Taking into account that the internal cavities in the parvalbumin are formed by hydrophobic amino acid residues, devoid of labile hydrogen atoms, it is possible to make the most appropriate assumption, namely, these cavities contain water molecules, hydrogen atoms of which are ultraslow exchangeable.	Hydrogen	130-138	parvalbumin	Homo sapiens	54-65
22873060-3	2012	Taking into account that the internal cavities in the parvalbumin are formed by hydrophobic amino acid residues, devoid of labile hydrogen atoms, it is possible to make the most appropriate assumption, namely, these cavities contain water molecules, hydrogen atoms of which are ultraslow exchangeable.	Hydrogen	250-258	parvalbumin	Homo sapiens	54-65
16193111-1	2005	A neutral electrochemical chemosensor based on TTF exhibited high selectivity for H2PO4- over a wide range of anions and the significant C-H...O hydrogen bonding between C=C-H of the TTF unit and H2PO4- played an important role in regulating the selectivity.	Hydrogen	145-153	ras homolog family member H	Homo sapiens	47-50
16144398-1	2005	Trialkylboranes (BMe3, BEt3, and BBu3) have been shown to mediate reductive deoxygenation reactions of O-alkyl-S-methyl dithiocarbonates (methyl xanthates) in which water or deuterium oxide functions as the source of hydrogen or deuterium.	Hydrogen	217-225	trafficking protein particle complex subunit 3	Homo sapiens	23-27
22270553-3	2012	In the current study, amide hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS) was used to examine the structural and dynamic properties of the MT complex with the microtubule binding domain of MAP4 (MTB-MAP4) in the presence and absence of Taxol.	Hydrogen	28-36	microtubule associated protein 4	Homo sapiens	211-215
22860199-0	2012	Solution structures of the prototypical 18 kDa translocator protein ligand, PK 11195, elucidated with 1H/13C NMR spectroscopy and quantum chemistry.	Hydrogen	102-104	translocator protein	Homo sapiens	47-67
16197001-0	2005	Apparent velocity threshold in the electronic stopping of slow hydrogen ions in LiF.	Hydrogen	63-71	LIF interleukin 6 family cytokine	Homo sapiens	80-83
22068262-3	2012	The hydrogen consumption rates were affected by both P(H2) (hydrogen partial pressure) and mixing intensity.	Hydrogen	4-12	polyhomeotic homolog 2	Homo sapiens	53-58
22068262-3	2012	The hydrogen consumption rates were affected by both P(H2) (hydrogen partial pressure) and mixing intensity.	Hydrogen	60-68	polyhomeotic homolog 2	Homo sapiens	53-58
2777799-6	1989	The distal histidine in this subunit inhibits the bimolecular rate of binding of both O2 and CO, sterically hinders bound CO and methyl isocyanide, and stabilizes bound O2 by hydrogen bonding.	Hydrogen	175-183	immunoglobulin kappa variable 1D-39	Homo sapiens	86-95
16197001-1	2005	The electronic energy loss of hydrogen ions (protons and deuterons) in thin supported films of LiF has been studied in backscattering geometry for specific energies from 700 eV/u to 700 keV/u, using Rutherford backscattering spectroscopy and time-of-flight low-energy ion scattering spectroscopy.	Hydrogen	30-38	LIF interleukin 6 family cytokine	Homo sapiens	95-98
16834185-3	2005	For the water-indole system, the more elaborate MP2 and MPW1B95 methods yield only one minimum with a hydrogen bond to the pyrrole part and weak secondary interactions to the phenyl ring, in agreement with a recent criticism by Van Mourik (Chem.	Hydrogen	102-110	tryptase pseudogene 1	Homo sapiens	48-51
22244776-5	2012	Hydrogen bonds and van der Waals interaction might be the predominant intermolecular forces in stabilizing FBP/SBPase-Mg2+ while hydrophobic forces were the predominant intermolecular forces in stabilizing FBP/SBPase-Mn2+.	Hydrogen	0-8	fructose-bisphosphatase 1	Homo sapiens	107-110
2547451-2	1989	Using the lipid-soluble spin trap 2-methyl-nitrosopropane (MNP), we have detected both the lipid and hydrogen-atom spin adducts in liposomes composed of a fully saturated phospholipid (dimyristoylphosphatidylcholine, DMPC) with various mol fractions of unsaturated phospholipid (1-palmitoyl-2-arachidonoylphosphatidylcholine, PAPC) or fatty acid (arachidonic acid, AA).	Hydrogen	101-109	spindlin 1	Homo sapiens	24-28
16106293-7	2005	Together the results reveal that for the "natural" C-2 stereochemistry of 2S-naringenin, C-3 hydroxylation predominates (&gt;9 : 1) over desaturation, probably due to the inaccessibility of the C-2 hydrogen to the iron centre.	Hydrogen	198-206	complement C2	Homo sapiens	51-54
2547451-2	1989	Using the lipid-soluble spin trap 2-methyl-nitrosopropane (MNP), we have detected both the lipid and hydrogen-atom spin adducts in liposomes composed of a fully saturated phospholipid (dimyristoylphosphatidylcholine, DMPC) with various mol fractions of unsaturated phospholipid (1-palmitoyl-2-arachidonoylphosphatidylcholine, PAPC) or fatty acid (arachidonic acid, AA).	Hydrogen	101-109	spindlin 1	Homo sapiens	115-119
2789994-7	1989	A wobble alignment of the O6alkG4.C9 base pair stablized by two hydrogen bonds, one between the amino group of C9 and N1 of O6alkG and the other between the amino group of O6alkG and N3 of C9, is tentatively proposed on the basis of the NOEs between the amino protons of C9 at the lesion site and the imino protons of flanking Watson-Crick base pairs.	Hydrogen	64-72	complement C9	Homo sapiens	111-130
22462862-0	2012	Spin-orbit quenching of Cl(2P(1/2)) by H2.	Hydrogen	39-41	spindlin 1	Homo sapiens	0-4
16106293-9	2005	1 : 1); this is probably a result of both the C-3 pro-S and C-2 hydrogen atoms being accessible to the reactive oxidising intermediate in this substrate.	Hydrogen	64-72	complement C2	Homo sapiens	60-63
22611921-6	2012	The positive rates of c-fos expression in the low-and high-dose groups were 54.6% and 51.3% at 12 h, and 83.2% and 73.0% at 24 h. The expression of c-fos mRNA detected by RT-PCR was upregulated at 30 min and 1h in PCB126 groups.	Hydrogen	208-210	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	22-27
22611921-6	2012	The positive rates of c-fos expression in the low-and high-dose groups were 54.6% and 51.3% at 12 h, and 83.2% and 73.0% at 24 h. The expression of c-fos mRNA detected by RT-PCR was upregulated at 30 min and 1h in PCB126 groups.	Hydrogen	208-210	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	148-153
26641900-4	2005	This method provides results for H2/PAH interactions in close agreement with MP2 and higher-level ab initio methods.	Hydrogen	33-35	tryptase pseudogene 1	Homo sapiens	77-80
22121121-8	2012	The dianion is especially prone to strong hydrogen-bonding interactions with trace water present in the organic solvents, resulting in a shift in the formal reduction potential of E(2) to more positive potentials as more water is added to the solvent.	Hydrogen	42-50	cystatin 12, pseudogene	Homo sapiens	180-184
2735927-2	1989	The structure shows a syn conformation about the glycosidic bond, stabilised by an intramolecular hydrogen bond between the 05" and N3 atoms.	Hydrogen	98-106	synemin	Homo sapiens	22-25
15869817-3	2005	A series of peptides corresponding to isolated regions of tau protein have been successfully synthesized using Fmoc-based chemistry and their conformations were determined by 1H NMR spectroscopy and circular dichroism (CD) spectroscopy.	Hydrogen	175-177	microtubule associated protein tau	Homo sapiens	58-61
2475172-3	1989	The O2" hydroxyl groups of both rC and araC residues form intramolecular hydrogen bonds with N2 of the 5" guanine residue and replace the bridging water molecules in the deep groove of Z-DNA, which stabilize the guanine in the syn conformation.	Hydrogen	73-81	synemin	Homo sapiens	227-230
2742853-5	1989	The magnitude of the change in Ki value suggests that in the complex, Lys-40 forms a salt bridge or hydrogen bond with an anionic moiety in PRI.	Hydrogen	100-108	ribonuclease/angiogenin inhibitor 1	Homo sapiens	140-143
22248451-9	2012	Our neutron model provides insights into the molecular stability of TTR related to the hydrogen-bond network, the pH sensitivity and the CH   O weak hydrogen bond.	Hydrogen	149-157	transthyretin	Homo sapiens	68-71
22396159-8	2012	The distinct topologies of the HBS of FGF19 and FGF23 prevent HS from direct hydrogen bonding with the backbone atoms of the HBS of these ligands and accordingly decrease the HS binding affinity of this subfamily.	Hydrogen	77-85	fibroblast growth factor 23	Homo sapiens	48-53
16211492-0	2005	1H, 15N and 13C resonance assignments of the heme-binding protein murine p22HBP.	Hydrogen	0-2	heme binding protein 1	Mus musculus	73-79
23019452-2	2012	It was found through NBO and AIM analyses that such an interaction contributes to structural stabilization and that the (1h)J(F,H(O)) coupling constant in the syn-exo isomer is modulated by the n(F) sigma*(OH) interaction, i.e., the quantum nature of the F   HO hydrogen bond.	Hydrogen	121-123	synemin	Homo sapiens	159-162
23019452-2	2012	It was found through NBO and AIM analyses that such an interaction contributes to structural stabilization and that the (1h)J(F,H(O)) coupling constant in the syn-exo isomer is modulated by the n(F) sigma*(OH) interaction, i.e., the quantum nature of the F   HO hydrogen bond.	Hydrogen	262-270	synemin	Homo sapiens	159-162
16008417-3	2005	1H and 31P NMR spectra following the addition of smaller amounts (&lt; 5 equiv moles) of PPh3 indicate that the reaction liberates a AuISC2Ph complex, as opposed to a SC2Ph thiol, disulfide, or anion.	Hydrogen	0-2	protein phosphatase 4 catalytic subunit	Homo sapiens	89-93
2730868-2	1989	The alternating sequence adopts an A-DNA conformation with a novel purine-purine extra-Watson-Crick hydrogen bond involving the central guanine G3 (G11) and adenine A13 (A5) in the deep groove.	Hydrogen	100-108	serine/threonine kinase 19	Homo sapiens	128-151
21636625-3	2012	The antioxidant enzyme glutathione peroxidase 1 (GPX1) is part of the enzymatic antioxidant defence, preventing oxidative damage to DNA, proteins and lipids by detoxifying hydrogen and lipid peroxides that may contribute to prostate cancer development.	Hydrogen	172-180	glutathione peroxidase 1	Homo sapiens	23-47
16050745-5	2005	MP2/aug-cc-pVTZ predicts that the intramolecular seven-membered ring N-H...O=C hydrogen-bonding strength has a value of 5.54 kcal/mol in glycine dipeptide and 5.73 and 5.19 kcal/mol in alanine dipeptides, while the steric repulsive interactions of the seven-membered ring conformers are 4.13 kcal/mol in glycine dipeptide and 6.62 and 3.71 kcal/mol in alanine dipeptides.	Hydrogen	79-87	tryptase pseudogene 1	Homo sapiens	0-3
21636625-3	2012	The antioxidant enzyme glutathione peroxidase 1 (GPX1) is part of the enzymatic antioxidant defence, preventing oxidative damage to DNA, proteins and lipids by detoxifying hydrogen and lipid peroxides that may contribute to prostate cancer development.	Hydrogen	172-180	glutathione peroxidase 1	Homo sapiens	49-53
2720119-4	1989	Concomitantly, the 1H-nmr spectrum of bombesin, in a D2O lipid dispersion, shows the persistence of resonances due to exchangeable protons and in similar conditions the fluorescence intensity increases.	Hydrogen	19-21	gastrin releasing peptide	Homo sapiens	38-46
16050745-6	2005	It was also found that MP26-311++G(3df,2p) gives as accurate intramolecular N-H...O=C hydrogen-bonding energies and steric repulsive interactions as the much more costly MP2/aug-cc-pVTZ does.	Hydrogen	86-94	tryptase pseudogene 1	Homo sapiens	23-26
22754368-3	2012	The results demonstrated that the proposed pharmacophore model containing two hydrogen-bond acceptors, two hydrogen-bond donors and two hydrophobic centers characterized the structural features of the sulfonamides necessary for MAb(SMR) binding.	Hydrogen	78-86	LY6/PLAUR domain containing 4	Homo sapiens	232-235
16022504-7	2005	This result confirmed formation of 3-pronged hydrogen bonds for the oxyanion hole of butyrylcholinesterase and 2-pronged hydrogen bonds for the oxyanion hole of acetylcholinesterase.	Hydrogen	45-53	butyrylcholinesterase	Homo sapiens	85-106
22754368-3	2012	The results demonstrated that the proposed pharmacophore model containing two hydrogen-bond acceptors, two hydrogen-bond donors and two hydrophobic centers characterized the structural features of the sulfonamides necessary for MAb(SMR) binding.	Hydrogen	107-115	LY6/PLAUR domain containing 4	Homo sapiens	232-235
22207005-5	2012	VDR hydrogen/deuterium exchange coupled mass spectrometry and computational results show differences between the abilities of 1,25D3 and curcuminoids to stabilize VDR helices associated with the regulation of gene transcription.	Hydrogen	4-12	vitamin D receptor	Homo sapiens	0-3
3266557-0	1988	1H NMR studies of human C3a anaphylatoxin in solution: sequential resonance assignments, secondary structure, and global fold.	Hydrogen	0-2	complement C3	Homo sapiens	24-27
3266557-1	1988	The spin systems that comprise the 1H nuclear magnetic resonance (NMR) spectrum of the complement fragment C3a (Mr 8900) have been completely identified by an approach which integrates data from a wide range of two-dimensional NMR experiments.	Hydrogen	35-37	complement C3	Homo sapiens	107-110
3246478-1	1988	In the crystal, the backbone of Boc-(Aib-Val-Ala-Leu)2-Aib-OMe adopts a helical form with four alpha-type hydrogen bonds in the middle, flanked by 3(10)-type hydrogen bonds at either end.	Hydrogen	106-114	ANIB1	Homo sapiens	55-58
3246478-1	1988	In the crystal, the backbone of Boc-(Aib-Val-Ala-Leu)2-Aib-OMe adopts a helical form with four alpha-type hydrogen bonds in the middle, flanked by 3(10)-type hydrogen bonds at either end.	Hydrogen	158-166	BOC cell adhesion associated, oncogene regulated	Homo sapiens	32-35
3246478-1	1988	In the crystal, the backbone of Boc-(Aib-Val-Ala-Leu)2-Aib-OMe adopts a helical form with four alpha-type hydrogen bonds in the middle, flanked by 3(10)-type hydrogen bonds at either end.	Hydrogen	158-166	ANIB1	Homo sapiens	37-40
3246478-1	1988	In the crystal, the backbone of Boc-(Aib-Val-Ala-Leu)2-Aib-OMe adopts a helical form with four alpha-type hydrogen bonds in the middle, flanked by 3(10)-type hydrogen bonds at either end.	Hydrogen	158-166	ANIB1	Homo sapiens	55-58
16035857-5	2005	For H2 on the zinc oxide corners, the MP2 binding energy using Zn4O(HCO2)6 molecule is 6.28 kJ/mol.	Hydrogen	4-6	tryptase pseudogene 1	Homo sapiens	38-41
9900789-0	1988	Spin-exchange frequency shifts in cryogenic and room-temperature hydrogen masers.	Hydrogen	65-73	spindlin 1	Homo sapiens	0-4
22571431-8	2012	Hydrogen binding statistical analysis reveals that E170 (hM1) and R34 (MT7) are both locked in electrostatic cages with counter charges, respectively.	Hydrogen	0-8	cholinergic receptor muscarinic 1	Homo sapiens	57-60
22524024-1	2012	In this study, we investigated the photochemical production of hydrogen from water using bio-inspired heterogeneous microporous porphyrin coordination lattices (PCLs), [Ru2(MTCPP)BF4] (M = H2 (PCL-1), Zn (PCL-2); TCPP = Tetrakis(4-carboxyphenyl)porphyrin), under visible (380 nm &lt;) and UV (320 nm &lt;) light irradiations.	Hydrogen	63-71	PHD finger protein 1	Homo sapiens	193-198
15938624-4	2005	Like the R2 structure, the diagnostic R state hydrogen bond between beta2His97 and alpha1Thr38 is missing in the RR2 structure.	Hydrogen	46-54	ribonucleotide reductase regulatory subunit M2	Homo sapiens	113-116
22524024-2	2012	In the presence of Na2EDTA (as a sacrificial donor) and MV2+ (methyl-vilologen; as a electron relay), PCLs exhibits photocatalytic activity for hydrogen evolution; the maximum amounts of turnover numbers (TONs) of PCL-1 and PCL-2 at 24 h irradiation were 20.8 and 29.9, respectively.	Hydrogen	144-152	PHD finger protein 1	Homo sapiens	214-219
9946857-0	1988	Spin-exchange and dipole relaxation rates in atomic hydrogen: Rigorous and simplified calculations.	Hydrogen	52-60	spindlin 1	Homo sapiens	0-4
3399389-1	1988	The conformation of 7-methylguanosine 5"-monophosphate (m7GMP) and its interaction with L-phenylalanine (Phe) have been investigated by X-ray crystallographic, 1H-nuclear magnetic resonance, and energy calculation methods.	Hydrogen	160-162	5'-nucleotidase, cytosolic II	Homo sapiens	58-61
15826953-0	2005	Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule.	Hydrogen	11-19	torsin family 1 member A	Homo sapiens	122-125
15826953-2	2005	The crystal structure of HLA-DQ2 complexed with the alphaI-gliadin epitope (LQPFPQPELPY) revealed four hydrogen bonds between DQ2 and peptide main chain amides.	Hydrogen	103-111	torsin family 1 member A	Homo sapiens	29-32
15826953-2	2005	The crystal structure of HLA-DQ2 complexed with the alphaI-gliadin epitope (LQPFPQPELPY) revealed four hydrogen bonds between DQ2 and peptide main chain amides.	Hydrogen	103-111	torsin family 1 member A	Homo sapiens	126-129
15826953-4	2005	Preserving main chain hydrogen bond interactions despite the presence of multiple proline residues in gluten peptides is a key element for the HLA-DQ2 association of celiac disease.	Hydrogen	22-30	torsin family 1 member A	Homo sapiens	147-150
3390427-3	1988	Conformational properties of the cis-syn dimers and adjacent thymine nucleotides have been investigated in solution by using 1H, 13C, and 31P NMR spectroscopy.	Hydrogen	125-127	synemin	Homo sapiens	37-40
15878286-3	2005	The BK1-5 [M + H](+) ions were also studied by gas-phase hydrogen/deuterium (H/D) exchange ion-molecule reactions and this data supports our interpretation of the IM-MS data.	Hydrogen	57-65	bradykinin receptor B2	Homo sapiens	4-9
15741158-4	2005	Ligand 1 occupies the S(1) and S(2) subsites of cathepsin G and chymase similarly, with the 2-naphthyl in S(1), the 1-naphthyl in S(2), and the phosphonate group in a complex network of hydrogen bonds.	Hydrogen	186-194	cathepsin G	Homo sapiens	48-59
3349071-7	1988	The C-15 cis double bond significantly lowers the temperature and enthalpy of the phase transition indicating that it increases the lateral separation of the lipid molecules and decreases the intermolecular hydrogen bonding interactions.	Hydrogen	207-215	placenta associated 8	Homo sapiens	4-8
15929008-0	2005	1H, 15N and 13C Resonance assignments and secondary structure determination reveal that the minimal Rac1 GTPase binding domain of plexin-B1 has a ubiquitin fold.	Hydrogen	0-2	plexin B1	Homo sapiens	130-139
15787563-5	2005	The second photoreaction process is photocyclization of cis-BSF, which occurs to give DP1 decaying with the half lifetime (tau1/2) of 2.8-4.0 micros to produce another DHP-type intermediate (DP2) with an absorption peak at 400 nm in the absence of O2, through [1,9]-hydrogen shift.	Hydrogen	266-274	transcription factor Dp-2	Homo sapiens	191-194
15665254-3	2005	DXMS analyses of inhibitor-bound versus inhibitor-free forms of matrilysin reveal two primary sites of reduced hydrogen/deuterium exchange (residues 145-153; residues 193-204) that flank the structural zinc binding site.	Hydrogen	111-119	matrix metallopeptidase 7	Homo sapiens	64-74
15755164-3	2005	Further reactions of 5 with Cp2ZrMe2 (8) and Cp2ZrHCl in toluene lead to the intermolecular elimination of CH4 and H2 and the formation of mu-O-bridged dinuclear aluminum and zirconium complexes [LAlMe(mu-O)ZrMeCp2] (6) and [LAlMe(mu-O)ZrClCp2] (7), respectively, in high yields.	Hydrogen	115-117	ceruloplasmin	Homo sapiens	28-31
15625718-4	2005	Molecular calculations of the phenazopyridines 2-4 show that the pyridine and phenyl groups are oriented in an antiperiplanar conformation with intramolecular hydrogen bonding between the N-b atom and the C-2 amino group preserving the E-azo stereochemistry.	Hydrogen	159-167	complement C2	Homo sapiens	205-208
15501716-1	2005	Sonochemical degradation of phenol was found to be enhanced in the presence of the volatile hydrogen atom scavengers CCl4 and perfluorohexane.	Hydrogen	92-100	C-C motif chemokine ligand 4	Homo sapiens	117-121
16833422-0	2005	Stabilization energies of the hydrogen-bonded and stacked structures of nucleic acid base pairs in the crystal geometries of CG, AT, and AC DNA steps and in the NMR geometry of the 5"-d(GCGAAGC)-3" hairpin: Complete basis set calculations at the MP2 and CCSD(T) levels.	Hydrogen	30-38	tryptase pseudogene 1	Homo sapiens	246-249
15657948-3	2005	The tight hydrogen-bonding network observed between the HLA-B*2705 B-pocket and the peptide P2 arginine guanadinium anchor explains why mutation of this residue during HIV infection results in loss of peptide binding, immune escape and progression to AIDS.	Hydrogen	10-18	major histocompatibility complex, class I, B	Homo sapiens	56-61
15537658-6	2005	Interestingly, only a single hydrogen bond between a peptide side chain and Fab-Hyb3 contributes to the interaction, but large buried surface areas with pronounced shape complementarity assure high affinity and specificity for MAGE-A1.	Hydrogen	29-37	FA complementation group B	Homo sapiens	76-79
15638586-4	2005	In particular, the H2(nu=1,j=0) total quenching cross section computed using the BMP potential was found to be a factor of 1000 larger than that obtained with the MR surface.	Hydrogen	19-21	bone morphogenetic protein 1	Homo sapiens	81-84
3342036-0	1988	A two dimensional 1H NMR study of the solution conformation of gastrin releasing peptide.	Hydrogen	18-20	gastrin releasing peptide	Homo sapiens	63-88
3342036-1	1988	An almost complete assignment of the 1H NMR spectrum of gastrin releasing peptide in dimethyl sulphoxide solution and aqueous solution has been carried out using two dimensional NMR techniques.	Hydrogen	37-39	gastrin releasing peptide	Homo sapiens	56-81
2828046-6	1988	It is suggested that in the [H2(ATP)]4-(2) dimer intermolecular ion pairs (and hydrogen bonds) are formed between the H+(N-1) site of one H2(ATP)2- and the gamma-P(OH)(O)-2 group of the other; in this way (a) the stack is further stabilized, and (b) the positive charges at the adenine residues are compensated (otherwise repulsion would occur as is evident from the adenosine systems).	Hydrogen	29-31	relaxin 2	Homo sapiens	138-146
2828046-6	1988	It is suggested that in the [H2(ATP)]4-(2) dimer intermolecular ion pairs (and hydrogen bonds) are formed between the H+(N-1) site of one H2(ATP)2- and the gamma-P(OH)(O)-2 group of the other; in this way (a) the stack is further stabilized, and (b) the positive charges at the adenine residues are compensated (otherwise repulsion would occur as is evident from the adenosine systems).	Hydrogen	79-87	relaxin 2	Homo sapiens	138-146
3665915-0	1987	The conformation of bombesin in solution as determined by two-dimensional 1H-NMR techniques.	Hydrogen	74-76	gastrin releasing peptide	Homo sapiens	20-28
3665915-1	1987	The 1H nuclear magnetic resonance spectrum of the tetradecapeptide, bombesin, has been assigned in (2H6)dimethyl sulphoxide solution and aqueous solution using two-dimensional techniques.	Hydrogen	4-6	gastrin releasing peptide	Homo sapiens	68-76
3600252-2	1987	Spin-echo methods have been used to effect solvent suppression during the collection of 400 and 500 MHz 1H NMR spectra of urine samples containing urea in the concentration range 0.7-1.2 M. There was a marked trough of water Tobs2 values in the pH range 2.6 to 4.1, due to acid-catalyzed proton exchange between urea and the solvent water.	Hydrogen	104-106	spindlin 1	Homo sapiens	0-4
3561423-2	1987	It is proposed that hydrogen-bonding schemes may involve tautomeric, ionized or conformational forms (syn, anti and wobble).	Hydrogen	20-28	synemin	Homo sapiens	102-105
3602048-3	1987	In this case intramolecular hydrogen bonding probably accounts principally for the presence of equal amounts of anti and syn isomers.	Hydrogen	28-36	synemin	Homo sapiens	121-124
3098173-0	1986	Mechanism of the glycine cleavage reaction: retention of C-2 hydrogens of glycine on the intermediate attached to H-protein and evidence for the inability of serine hydroxymethyltransferase to catalyze the glycine decarboxylation.	Hydrogen	61-70	complement C2	Bos taurus	57-60
3098173-4	1986	The results presented in this paper indicate that the decarboxylation is not accompanied by the removal of a C-2 hydrogen atom of glycine and instead both C-2 hydrogens are transferred with the alpha carbon atom to the intermediate formed during the decarboxylation of glycine.	Hydrogen	159-168	complement C2	Bos taurus	155-158
3098281-3	1986	1H NMR chemical shifts were measured in 1, 2, and a protected derivative, Boc-Asp(OBzl)-Pro-Aib-His-NHMe (3).	Hydrogen	0-2	ANIB1	Homo sapiens	92-95
3022496-1	1986	1H NMR studies on DPPC vesicles labeled with the spin labels (1,14) or (12,3) have shown that both of the spin labels influence the fatty acid side chains as well as the choline head groups.	Hydrogen	0-2	spindlin 1	Homo sapiens	49-53
3022496-1	1986	1H NMR studies on DPPC vesicles labeled with the spin labels (1,14) or (12,3) have shown that both of the spin labels influence the fatty acid side chains as well as the choline head groups.	Hydrogen	0-2	spindlin 1	Homo sapiens	106-110
2870921-2	1986	When (methyl-2H3)methylmalonyl-CoA was reacted with partially purified methylmalonyl-CoA mutase, 1H-NMR revealed that about 24% of the migrating deuterium was lost after 88% conversion.	Hydrogen	97-99	methylmalonyl-CoA mutase	Homo sapiens	71-95
3955091-3	1986	The corresponding calculation discovered significance of intermolecular phosphate-phosphate hydrogen bonds in induced conductance of BLM.	Hydrogen	92-100	BLM RecQ like helicase	Homo sapiens	133-136
23300424-5	2012	By identifying the dynamically responsive protein regions and specific cross-domain hydrogen-bonding patterns that differentiate Hsp70 from Hsp110 as a function of the nucleotide, we propose a molecular mechanism for the allosteric signal propagation of the ATP-encoded conformational signal.	Hydrogen	84-92	heat shock protein family A (Hsp70) member 4	Homo sapiens	129-134
21960464-6	2012	The movement initiates rearrangement of the system of hydrogen bonds between TM2, TM3 and TM7 including formation of the hydrogen bond between the side chains of D82(2.50) in TM2 and N296(7.49) in TM7, which is crucial for formation of the activated states of the C5a receptors (Nikiforovich et al., Proteins: Struct Funct Gene 2011;79:787-802).	Hydrogen	54-62	tropomyosin 3	Homo sapiens	82-85
21960464-6	2012	The movement initiates rearrangement of the system of hydrogen bonds between TM2, TM3 and TM7 including formation of the hydrogen bond between the side chains of D82(2.50) in TM2 and N296(7.49) in TM7, which is crucial for formation of the activated states of the C5a receptors (Nikiforovich et al., Proteins: Struct Funct Gene 2011;79:787-802).	Hydrogen	121-129	tropomyosin 3	Homo sapiens	82-85
22065478-8	2011	Hydrogen bonding between the aliphatic substituents and the ether oxygen in the PPE derivatives has a significant influence on the BDE.	Hydrogen	0-8	homeobox D13	Homo sapiens	131-134
22082147-4	2011	Our previous molecular dynamics simulation studies of Xanthomonas campestris TDO (xcTDO) showed that a hydrogen bond between T254 (T342 in hTDO) and the ammonium group of the substrate is present in the L-Trp-bound enzyme, but not in the D-Trp-bound enzyme.	Hydrogen	103-111	tryptophan 2,3-dioxygenase	Homo sapiens	77-80
22082147-4	2011	Our previous molecular dynamics simulation studies of Xanthomonas campestris TDO (xcTDO) showed that a hydrogen bond between T254 (T342 in hTDO) and the ammonium group of the substrate is present in the L-Trp-bound enzyme, but not in the D-Trp-bound enzyme.	Hydrogen	103-111	tryptophan 2,3-dioxygenase	Homo sapiens	139-143
22027839-4	2011	We have used small angle x-ray scattering, hydrogen/deuterium exchange kinetics, and Forster resonance energy transfer measurements to determine the low-resolution solution structure of the 14-3-3zeta RGS3 complex.	Hydrogen	43-51	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	190-200
22152677-7	2011	In silico analysis of KIF22 protein structure indicates that Pro148 and Arg149 are important in maintaining hydrogen bonds in the ATP binding and motor domains of KIF22.	Hydrogen	108-116	kinesin family member 22	Homo sapiens	22-27
22152677-7	2011	In silico analysis of KIF22 protein structure indicates that Pro148 and Arg149 are important in maintaining hydrogen bonds in the ATP binding and motor domains of KIF22.	Hydrogen	108-116	kinesin family member 22	Homo sapiens	163-168
22015602-9	2011	In addition, hydrogen decreased malonaldehyde and nitrotyrosine content, inhibited myeloperoxidase and maintained superoxide dismutase activity in lung tissues and associated with a decrease in the expression of TNF-alpha, IL-1beta, IL-6 and total protein concentrations in the BALF.	Hydrogen	13-21	myeloperoxidase	Mus musculus	83-98
22015602-11	2011	Importantly, hydrogen inhibited the activation of P-JNK, and also reversed changes in Bax, Bcl-xl and caspase-3.	Hydrogen	13-21	BCL2-associated X protein	Mus musculus	86-89
22015602-11	2011	Importantly, hydrogen inhibited the activation of P-JNK, and also reversed changes in Bax, Bcl-xl and caspase-3.	Hydrogen	13-21	caspase 3	Mus musculus	102-111
22015602-12	2011	In conclusion, our data demonstrated that hydrogen inhalation ameliorated LPS-induced ALI and it may be exerting its protective role by preventing the activation of ROS-JNK-caspase-3 pathway.	Hydrogen	42-50	caspase 3	Mus musculus	173-182
22105349-4	2011	We provide evidence that cortactin-cofilin binding is regulated by local pH changes at invadopodia that are mediated by the sodium-hydrogen exchanger NHE1.	Hydrogen	131-139	cortactin	Homo sapiens	25-34
22026550-0	2011	A hydrogen bond motif giving a variety of supramolecular assembly structures and spin-crossover behaviors.	Hydrogen	2-10	spindlin 1	Homo sapiens	81-85
21942421-6	2011	While in steps (b) and (c), their collaboration are demonstrated by the formation of an anagostic interaction between Ru and the C-H bond and two ionic hydrogen bonds supported by the PNN ligand.	Hydrogen	152-160	pinin, desmosome associated protein	Homo sapiens	184-187
22220129-3	2011	The syn arrangement of the amide H and carbonyl O atoms allows for the formation of centrosymmetric dimers via N-H O hydrogen bonds.	Hydrogen	117-125	synemin	Homo sapiens	4-7
21890340-1	2011	The study reports production of hydrogen in photobioreactors with free (PBR(Fr)) and immobilized (PBR(Imm)) Nostoc biomass at enhanced and sustained rates.	Hydrogen	32-40	translocator protein	Homo sapiens	72-75
21890340-1	2011	The study reports production of hydrogen in photobioreactors with free (PBR(Fr)) and immobilized (PBR(Imm)) Nostoc biomass at enhanced and sustained rates.	Hydrogen	32-40	translocator protein	Homo sapiens	98-101
21972974-8	2011	Conversely, the docked MMP9-D2 structure shows hydrophobic and hydrogen bonding between the ligand"s morpholine substituent and second carboxylic acid group with Leu187 and an amide, respectively.	Hydrogen	63-71	matrix metallopeptidase 9	Homo sapiens	23-27
22038811-6	2011	In both the cases, we have found that p28 is able to form with DBD a complex characterized by favourable negative binding free energy, high shape complementarity, and the presence of several hydrogen bonds at the interface.	Hydrogen	191-199	golgi SNAP receptor complex member 1	Homo sapiens	38-41
21919471-4	2011	An intramolecular hydrogen bond between the atom OD of Asp11(TPX2) and the atom HE1 of Trp34(TPX2) disappear in three mutants and thus lead to the instability of the secondary structure of TPX2.	Hydrogen	18-26	TPX2, microtubule-associated S homeolog	Xenopus laevis	61-65
21919471-4	2011	An intramolecular hydrogen bond between the atom OD of Asp11(TPX2) and the atom HE1 of Trp34(TPX2) disappear in three mutants and thus lead to the instability of the secondary structure of TPX2.	Hydrogen	18-26	TPX2, microtubule-associated S homeolog	Xenopus laevis	93-97
21919471-4	2011	An intramolecular hydrogen bond between the atom OD of Asp11(TPX2) and the atom HE1 of Trp34(TPX2) disappear in three mutants and thus lead to the instability of the secondary structure of TPX2.	Hydrogen	18-26	TPX2, microtubule-associated S homeolog	Xenopus laevis	93-97
21795109-2	2011	The difference in the chemical shift of equatorial methylene proton and axial methylene proton at C(5) [Delta = delta(eq)-delta(ax)] is highly negative which is in contrast to the value observed in the corresponding parent piperidin-4-ones and this is attributed to the syn 1,3-diaxial interaction between the axial N-H bond and axial hydrogen at C-5.	Hydrogen	335-343	synapsin I	Homo sapiens	270-275
21970810-17	2011	The metabolome of T-CD and HC children was studied using faecal and urine samples which were analyzed by gas-chromatography mass spectrometry-solid-phase microextraction and 1H-Nuclear Magnetic Resonance.	Hydrogen	174-176	CHM Rab escort protein	Homo sapiens	18-22
22039610-3	2011	Computer simulation and circular dichrosim show that neat CS-A and CS-C have weak intramolecular hydrogen bonding and extended conformations in solution resulting in energetically more favorable interactions with nanotubes.	Hydrogen	97-105	chorionic somatomammotropin hormone 1	Homo sapiens	58-62
22058755-1	2011	The title mol-ecule, C(13)H(17)ClN(2)O(3)S, shows an anti and syn disposition of the butanoyl and 2,5-dimethoxyphenyl groups with respect to the thione and is stabilized by intra-molecular N-H O and weak C-H S hydrogen bonds.	Hydrogen	210-218	synemin	Homo sapiens	62-65
21956331-5	2011	Here we report structural links between the receptor-binding surface and the nucleotide-binding pocket of Gs that undergo higher levels of hydrogen-deuterium exchange than would be predicted from the crystal structure of the beta(2)AR-Gs complex.	Hydrogen	139-147	adrenoceptor beta 2	Homo sapiens	225-234
21384338-3	2011	A complete analysis of the hydrogen-bonding (HB) and non-bonded (VDW) interactions over the course of the MD simulations suggested that changes in the interactions in the free U1A protein caused by the Phe56Ala and Phe56Leu mutations may stabilize the helical character in loop 3, and contribute to the weak binding of these proteins to SL2 RNA.	Hydrogen	27-35	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	176-179
21638318-6	2011	In this study we postulated that the auxiliary alpha(2) delta subunit of the VSCC complex modulates mechanically regulated ATP release in osteocytes via its association with the T-type Ca(v) 3.2 (alpha(1H) ) subunit.	Hydrogen	202-204	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	178-194
21680215-5	2011	The results demonstrate that NNK was able to form a hydrogen bond with Asn297 in either CYP2A13 or CYP2A6.	Hydrogen	52-60	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	88-95
21680215-5	2011	The results demonstrate that NNK was able to form a hydrogen bond with Asn297 in either CYP2A13 or CYP2A6.	Hydrogen	52-60	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	99-105
21680215-6	2011	The hydrogen-bond acceptor was the pyridine nitrogen of NNK in the CYP2A13 complex, but it changed to the carbonyl oxygen in the CYP2A6 complex.	Hydrogen	4-12	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	67-74
21680215-6	2011	The hydrogen-bond acceptor was the pyridine nitrogen of NNK in the CYP2A13 complex, but it changed to the carbonyl oxygen in the CYP2A6 complex.	Hydrogen	4-12	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	129-135
3949624-3	1986	The cephems (2a and 2b) having a C-3 substituent such as hydrogen or vinyl were more potent than other cephalosporins against Gram-negative bacteria.	Hydrogen	57-65	complement C3	Rattus norvegicus	33-36
15617814-3	2005	In particular, all conformations with the C7 hydrogen bond between acetyl and amide ends, which is the most probable conformations of Ac-Pro-NHMe in the gas phase and in nonpolar solvents, disappeared for Ac-Pro-NMe2 even in the gas phase due to the lack of amide hydrogen.	Hydrogen	45-53	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	212-216
2414103-2	1985	Near complete sequence specific assignment of the 1H NMR spectrum of c-BPTI has been obtained in a highly efficient manner, using recently developed experimental techniques.	Hydrogen	50-52	spleen trypsin inhibitor I	Bos taurus	71-75
21785987-1	2011	The solution NMR structure of protein MED25(391-543), comprising the activator interacting domain (ACID) of subunit 25 of the human mediator, is presented along with the measurement of polypeptide backbone heteronuclear 15N-{1H} NOEs to identify fast internal motional modes.	Hydrogen	225-227	mediator complex subunit 25	Homo sapiens	38-43
15617814-3	2005	In particular, all conformations with the C7 hydrogen bond between acetyl and amide ends, which is the most probable conformations of Ac-Pro-NHMe in the gas phase and in nonpolar solvents, disappeared for Ac-Pro-NMe2 even in the gas phase due to the lack of amide hydrogen.	Hydrogen	264-272	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	212-216
15617814-6	2005	It should be noted that Ac-Pro-NMe2 has higher rotational barriers for the cis-trans isomerization of the Ac-Pro peptide bond than Ac-Pro-NHMe in the gas phase and in solutions, which could be due to the lack of the intramolecular hydrogen bond between prolyl nitrogen and carboxyl N-H group for the transition state of Ac-Pro-NMe2.	Hydrogen	231-239	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	31-35
16059664-4	2005	For all COX-2-selective inhibitors under consideration, we find that free energies of binding become less favorable as the receptor changes from COX-2 to COX-1, due to the weakening and/or loss of hydrogen bond and hydrophobic interactions that stabilize the inhibitors in the COX-2 active site.	Hydrogen	197-205	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	154-159
2993522-3	1985	Data are presented to indicate that the following molecular interactions are essential for activation of the phosphorylation of MAP2: (a) hydrogen bond formation toward the 2", 3", or 5" position, (b) interaction with phosphorus, and (c) no hydrogen bonds but hydrophobic interactions at the base moiety.	Hydrogen	138-146	microtubule associated protein 2	Homo sapiens	128-132
2993522-3	1985	Data are presented to indicate that the following molecular interactions are essential for activation of the phosphorylation of MAP2: (a) hydrogen bond formation toward the 2", 3", or 5" position, (b) interaction with phosphorus, and (c) no hydrogen bonds but hydrophobic interactions at the base moiety.	Hydrogen	241-249	microtubule associated protein 2	Homo sapiens	128-132
16463701-15	2005	In case of all the 1H MRS spectra obtained from the subcortical nuclei regions significant decrease in the NAA/tCr ratio was observed which could reflect the reduced concentration of N-acetyloaspartate, known as a neurons marker.	Hydrogen	19-21	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	111-114
4052368-5	1985	Careful scrutiny of the 1H NMR spectrum of freshly prepared hemoglobin A (Hb A) reveals that characteristic resonances for the alternate heme orientation are present in both subunits, clearly demonstrating that "native" Hb A possesses an important structure heterogeneity.	Hydrogen	24-26	sodium voltage-gated channel alpha subunit 2	Homo sapiens	60-72
4052368-5	1985	Careful scrutiny of the 1H NMR spectrum of freshly prepared hemoglobin A (Hb A) reveals that characteristic resonances for the alternate heme orientation are present in both subunits, clearly demonstrating that "native" Hb A possesses an important structure heterogeneity.	Hydrogen	24-26	sodium voltage-gated channel alpha subunit 2	Homo sapiens	74-78
4052368-5	1985	Careful scrutiny of the 1H NMR spectrum of freshly prepared hemoglobin A (Hb A) reveals that characteristic resonances for the alternate heme orientation are present in both subunits, clearly demonstrating that "native" Hb A possesses an important structure heterogeneity.	Hydrogen	24-26	sodium voltage-gated channel alpha subunit 2	Homo sapiens	220-224
15571384-4	2004	These observations implicate a decarboxylation mechanism in which Pro-1 polarizes the carbonyl oxygen of substrate by hydrogen bonding and/or an electrostatic interaction.	Hydrogen	118-126	lamin A/C	Homo sapiens	66-71
15554712-1	2004	Using amide hydrogen exchange combined with electrospray ionization mass spectrometry, we have in this study determined the number of amide hydrogens on several peptides that become solvent-inaccessible as a result of their high-affinity interaction with the urokinase-type plasminogen activator receptor (uPAR).	Hydrogen	12-20	plasminogen activator, urokinase receptor	Homo sapiens	259-304
2863229-7	1985	An equilibrium involving two gamma turn conformations stabilized respectively by Cys2-D-Trp4 and Phe3-Lys5 hydrogen bonds, is responsible for the large upfield shift observed for the Lys5 gamma protons and is compatible with the measured JNH-C alpha H coupling constants.	Hydrogen	107-115	transient receptor potential cation channel subfamily C member 4	Homo sapiens	88-92
15337743-1	2004	An adaptation of PAI-1 conformer crystal structures by hydrogen-deuterium exchange.	Hydrogen	55-63	serpin family E member 1	Homo sapiens	17-22
2863229-7	1985	An equilibrium involving two gamma turn conformations stabilized respectively by Cys2-D-Trp4 and Phe3-Lys5 hydrogen bonds, is responsible for the large upfield shift observed for the Lys5 gamma protons and is compatible with the measured JNH-C alpha H coupling constants.	Hydrogen	107-115	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	102-106
2863229-7	1985	An equilibrium involving two gamma turn conformations stabilized respectively by Cys2-D-Trp4 and Phe3-Lys5 hydrogen bonds, is responsible for the large upfield shift observed for the Lys5 gamma protons and is compatible with the measured JNH-C alpha H coupling constants.	Hydrogen	107-115	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	183-187
15337743-6	2004	In this study, backbone amide hydrogen-deuterium exchange detected by mass spectrometry was used to characterize dynamic and structural alterations of human PAI-1 (hPAI-1) in relation to its function.	Hydrogen	30-38	serpin family E member 1	Homo sapiens	157-162
3916949-1	1985	Perturbation of the hydrogen bonds in the adenine ... thymine base pair by Na+, Mg2+, Ca2+ and NH4+ cations has been investigated by means of ab initio SCF calculations with the STO-3G basis set.	Hydrogen	20-28	KIT ligand	Homo sapiens	152-155
15337743-6	2004	In this study, backbone amide hydrogen-deuterium exchange detected by mass spectrometry was used to characterize dynamic and structural alterations of human PAI-1 (hPAI-1) in relation to its function.	Hydrogen	30-38	serpin family E member 1	Homo sapiens	164-170
15558666-0	2004	A purely organic molecular metal based on a hydrogen-bonded charge-transfer complex: crystal structure and electronic properties of TTF-imidazole-p-chloranil.	Hydrogen	44-52	ras homolog family member H	Homo sapiens	132-135
2990531-8	1985	The 53 ppm downfield shift upon the addition of substrate along with 1H NMR data suggests that one oxygen ligand to Cd2+ in the binary complex is replaced by a nitrogen ligand at some intermediate point in the enzymic reaction.	Hydrogen	69-71	T-cell surface antigen CD2	Oryctolagus cuniculus	116-119
2859863-3	1985	In studies on structure-activity relationships of histamine H2-receptor antagonists, C-2 basically substituted thiazoles were prepared and tested for their H2-antihistaminic activity on the isolated guinea-pig atrium and on the histamine stimulated acid secretion of the anaesthetized rat.	Hydrogen	60-62	complement C2	Cavia porcellus	85-88
15388247-12	2004	Lower DEM doses (0.125 mM and 0.25 mM) for 1h had no significant effect on GSH but significantly decreased Trx activity 12 and 23%, respectively.	Hydrogen	43-45	thioredoxin	Cricetulus griseus	107-110
6375666-2	1984	Substitution of deuterium for hydrogen at the terminal carbon atoms (C-3) of Tris-BP significantly decreased both the mutagenic response and the formation rate of 2- bromoacrolein .	Hydrogen	30-38	complement C3	Homo sapiens	69-72
15541293-4	2004	MAN I as well as MAN II showed highest activity at pH 4.5 and 60 degrees C and were stable in the pH range 4.5-8.5 and up to 55 degrees C. In accordance with the ability of the enzymes to catalyze transglycosylation reactions, 1H NMR spectroscopy of reaction products generated from mannopentaitol confirmed the retaining character of both enzymes.	Hydrogen	227-229	family with sequence similarity 168 member B	Homo sapiens	0-5
6232955-0	1984	[The role of ATPase subunits from E. coli in hydrogen-potassium exchange].	Hydrogen	45-53	ATPase	Escherichia coli	13-19
15477167-6	2004	Both the MP2 and B3LYP calculations located three minima corresponding to cyclic HCOOH...H2O complexes with two hydrogen bond interactions.	Hydrogen	112-120	tryptase pseudogene 1	Homo sapiens	9-12
6626573-2	1983	The 1H-NMR chemical shifts of the previously assigned anomeric and H-2 protons from the peripheral residues of the glycopeptide are identical to the corresponding values for the reduced oligosaccharide.	Hydrogen	4-6	relaxin 2	Homo sapiens	67-70
15476401-3	2004	We have used hydrogen-deuterium exchange mass spectrometry and directed mutagenesis to identify the secondary structure elements that form the binding sites of new Eg5 inhibitors, in particular for S-trityl-l-cysteine, a potent inhibitor of Eg5 activity in vitro and in cell-based assays.	Hydrogen	13-21	kinesin family member 11	Homo sapiens	164-167
6311534-8	1983	In particular, a doublet at -1 ppm, exhibited by both kringles and also found in reported proton spectra of homologous bovine prothrombin fragments, has been assigned to Leu46, a residue that is conserved in all of the kringles studied to date by 1H-NMR.	Hydrogen	247-249	coagulation factor II, thrombin	Bos taurus	126-137
15469902-5	2004	It is presumed that P101 induced a conformational change in the Q99 residue of WASP and made the side chain of Q99 move away from the WIP peptide, resulting in disruption of the hydrogen bond between Q99 WASP and Y475 WIP.	Hydrogen	178-186	WASP actin nucleation promoting factor	Homo sapiens	204-208
6887246-6	1983	The distributions of CO-N and NH-O hydrogen bond angles in the alpha-helices and beta-sheet structures of carboxypeptidase A are centered about 156 degrees.	Hydrogen	35-43	cytochrome c oxidase subunit 7A1	Bos taurus	106-124
15453753-1	2004	Multiple deuterium exchange between DMSO-d6 and amide hydrogens in two hexaamido cryptand fluoride receptors has been verified by 19F and 2H NMR and FAB mass spectral studies.	Hydrogen	54-63	FA complementation group B	Homo sapiens	149-152
6658886-2	1983	1H NMR spectra of all four 17 xi-hydroxy/17 xi-methyl C-3 ketones and all eight C-3 alcohols were recorded in chloroform-d and pyridine-d5.	Hydrogen	0-2	complement C3	Homo sapiens	54-57
6658886-2	1983	1H NMR spectra of all four 17 xi-hydroxy/17 xi-methyl C-3 ketones and all eight C-3 alcohols were recorded in chloroform-d and pyridine-d5.	Hydrogen	0-2	complement C3	Homo sapiens	80-83
15610614-7	2004	Obtained results indicate that the presence of the additional phenol group at C-5 in GAM favours the formation of intramolecular hydrogen bonding of the O...HO type between C2-OH proton and oxygen atom of the amide group.	Hydrogen	129-137	complement C5	Homo sapiens	78-81
6818352-0	1982	Effects of binding of S-peptide and 2"-cytidine monophosphate on hydrogen exchange from the S-protein component of ribonuclease S. The amide protons of serine 123 and valine 124.	Hydrogen	65-73	vitronectin	Homo sapiens	92-101
6287278-2	1982	Specific recognition of 2"-guanylic acid arises from hydrogen bonding between main chain peptide groups and the O-6 and N-1-H of guanine, as well as from stacking of Tyr 45 on guanine.	Hydrogen	53-61	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	112-115
21596781-7	2011	There are two hydrogen bonds between the Watson-Crick edge of G(anti) and the Hoogsteen edge of G(syn): O6 N1H and N7 N2H.	Hydrogen	14-22	synemin	Homo sapiens	98-101
15362123-9	2004	Thus, besides the salt bridges and hydrogen bonds, edge-to-face interactions significantly contribute to arylpiperazine ligands forming complexes with the D(2) DAR.	Hydrogen	35-43	adrenoceptor alpha 1D	Homo sapiens	160-163
21750807-2	2011	In the gas phase, H(3)O is a radical with spin density localized on its hydrogen end, which is only kinetically stable and readily decomposes into a water molecule and a hydrogen atom.	Hydrogen	72-80	H3 clustered histone 15	Homo sapiens	18-23
21750807-2	2011	In the gas phase, H(3)O is a radical with spin density localized on its hydrogen end, which is only kinetically stable and readily decomposes into a water molecule and a hydrogen atom.	Hydrogen	170-178	H3 clustered histone 15	Homo sapiens	18-23
15300160-8	2004	The related protein, RhAG, appears to be an erythroid-specific protein that mediates ammonium/hydrogen ion (NH4/H) exchange.	Hydrogen	94-102	Rh associated glycoprotein	Homo sapiens	21-25
21554249-3	2011	1H-NMR spectroscopy revealed the presence of a flexible and unstructured C-terminal extension, 12 amino acids in length, which protrudes from the domain core of 14-3-3zeta and is similar in structure and length to the C-terminal extension of mammalian sHsps.	Hydrogen	0-2	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	161-171
7132795-0	1982	[Formation of B group vitamins by the thermophilic hydrogen-oxidizing bacterium Pseudomonas thermophila K-2].	Hydrogen	51-59	RBPJ pseudogene 3	Homo sapiens	104-107
15240144-3	2004	1H-NMR, CD spectrum, and ANS binding assay show that endostatin at pH 2.0 contains little tertiary structure, but retains substantial secondary structure with strong ANS binding, and Na2SO4 or TFE is found to strongly stabilize endostatin at pH 2.0.	Hydrogen	0-2	collagen type XVIII alpha 1 chain	Homo sapiens	53-63
6281334-1	1982	The slow-reacting substance (SRS) bioactivity of leukotrienes C4 (LTC4) and D4 (LTD4) was rapidly decreased by incubation with eosinophil peroxidase (EPO), H2O2, and iodide, bromide, or to a lesser degree, chloride, LTB4 chemotactic activity was also decreased by the EPO-H2-H2-halide system, although at a slower rate.	Hydrogen	272-274	eosinophil peroxidase	Equus caballus	127-148
21553808-8	2011	We have employed peptide amide hydrogen-deuterium exchange mass spectrometry (DXMS) to characterize the association of Lp-PLA(2) with dimyristoylphosphatidylcholine (DMPC) vesicles and found that specific residues 113-120 in one of the enzyme"s surface-disposed hydrophobic alpha-helices likely mediate liposome binding.	Hydrogen	31-39	phospholipase A2 group VII	Homo sapiens	119-127
21476533-2	2011	After a 248 nm excimer laser flash, the first excited triplet state of AQDS is rapidly formed and then quenched by abstraction of a hydrogen atom from the alkyl chain of the micelle surfactant, leading to a spin-correlated radical pair (SCRP).	Hydrogen	132-140	spindlin 1	Homo sapiens	207-211
15255758-1	2004	Unique hydrogen bonds of the 9-H of anthracene moieties in hosts 1 and 2 with fluoride and pyrophosphate ions were observed on the basis of the (1)H NMR experiments.	Hydrogen	7-15	competing endogenous lncRNA 2 for microRNA let-7b	Homo sapiens	59-72
21556330-0	2011	Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network.	Hydrogen	105-113	complement component 1, s subcomponent 1	Mus musculus	32-47
21556330-1	2011	BACKGROUND: Canonical serine protease inhibitors commonly bind to their targets through a rigid loop stabilised by an internal hydrogen bond network and disulfide bond(s).	Hydrogen	127-135	complement component 1, s subcomponent 1	Mus musculus	22-37
7043400-2	1982	An A(syn)-G(trans) hydrogen-bonded basepair is proposed.	Hydrogen	19-27	synemin	Homo sapiens	5-8
15177448-4	2004	Again, presence of methoxy group at R1 and hydrogen, unsubstituted phenyl or fluoro-substituted phenyl group at R2 is conducive to the MT1 binding affinity.	Hydrogen	43-51	metallothionein 1I, pseudogene	Homo sapiens	135-138
6271696-6	1981	The three other reactions could be conveniently monitored in gamma-irradiated polycrystalline alanine at 110 degrees C. The first of the other three reactions takes place between the methyl hydrogens of the radicals and the C-2 hydrogens of nearby molecules, while the remaining processes involve exchange between the hydrogen atoms of the amino group and those on the C-2 and C-3 carbon atoms of the deamination radical.	Hydrogen	190-199	complement C3	Homo sapiens	377-380
6271696-6	1981	The three other reactions could be conveniently monitored in gamma-irradiated polycrystalline alanine at 110 degrees C. The first of the other three reactions takes place between the methyl hydrogens of the radicals and the C-2 hydrogens of nearby molecules, while the remaining processes involve exchange between the hydrogen atoms of the amino group and those on the C-2 and C-3 carbon atoms of the deamination radical.	Hydrogen	228-237	complement C3	Homo sapiens	377-380
6271696-6	1981	The three other reactions could be conveniently monitored in gamma-irradiated polycrystalline alanine at 110 degrees C. The first of the other three reactions takes place between the methyl hydrogens of the radicals and the C-2 hydrogens of nearby molecules, while the remaining processes involve exchange between the hydrogen atoms of the amino group and those on the C-2 and C-3 carbon atoms of the deamination radical.	Hydrogen	190-198	complement C3	Homo sapiens	377-380
21414781-2	2011	In general, reported CRF(1) receptor antagonists possess a sp(2)-nitrogen atom as hydrogen bonding acceptor (HBA) on their core scaffolds.	Hydrogen	82-90	corticotropin releasing hormone receptor 1	Mus musculus	21-36
21384891-9	2011	It is likely that hydrogen bonding in the enolate-buffer acid encounter complex is an important stereochemical determinant in producing a greater amount of the 2R*, 3S* diastereomer (the syn product).	Hydrogen	18-26	synemin	Homo sapiens	187-190
15224332-6	2004	IRAS also revealed a higher order of the odd-numbered chains and an increasing hydrogen-bonding contribution with increasing chain length.	Hydrogen	79-87	nischarin	Homo sapiens	0-4
20927613-0	2011	Backbone 1H, 13C, and 15N assignments for the tandem ubiquitin binding domains of signal transducing adapter molecule 1.	Hydrogen	9-11	signal transducing adaptor molecule	Homo sapiens	82-119
7284311-14	1981	For optimal binding in the absence of Ca2+, a long-distance hydrogen bond between these two residues is required; this can be established via a water molecule.	Hydrogen	60-68	carbonic anhydrase 2	Homo sapiens	38-41
15033987-7	2004	Furthermore, co-immunoprecipitation of RyR1 with 33 various mutants for the 9 positions produced by introducing different size, charge, and hydrophobicity revealed that an integration of the hydrogen bonds by the irreplaceable Gln-3 and the hydrophobic interactions by the residues Arg-18 and Met-49 could be a possible mechanism for the binding of FKBP12 to RyR1.	Hydrogen	191-199	ryanodine receptor 1	Oryctolagus cuniculus	39-43
6787598-1	1981	Evidence is presented to show that nonsteroidal antiinflammatory drugs react with two sites on the cyclooxygenase (8,11,14-eicosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.1).	Hydrogen	140-148	thioredoxin reductase 1	Homo sapiens	162-176
6260763-9	1981	The pKa for His-91 was shifted to the alkaline side in the presence of 3"-GMP, a competitive inhibitor, in the titration plots observed by both hydrogen-tritium exchange and 1H NMR spectroscopy.	Hydrogen	144-152	5'-nucleotidase, cytosolic II	Homo sapiens	74-77
6260763-9	1981	The pKa for His-91 was shifted to the alkaline side in the presence of 3"-GMP, a competitive inhibitor, in the titration plots observed by both hydrogen-tritium exchange and 1H NMR spectroscopy.	Hydrogen	174-176	5'-nucleotidase, cytosolic II	Homo sapiens	74-77
21178106-8	2011	Trafficking of alpha(1H)-GFP was also disrupted by cotransfection of HEK-293 cells with the dominant-negative form of ADP-ribosylation factor (ARF)1 but not ARF6, suggesting that ARF1 regulates the LIF-evoked membrane trafficking of alpha(1H)-GFP subunits.	Hydrogen	21-23	ADP ribosylation factor 1	Homo sapiens	143-148
21178106-8	2011	Trafficking of alpha(1H)-GFP was also disrupted by cotransfection of HEK-293 cells with the dominant-negative form of ADP-ribosylation factor (ARF)1 but not ARF6, suggesting that ARF1 regulates the LIF-evoked membrane trafficking of alpha(1H)-GFP subunits.	Hydrogen	21-23	ADP ribosylation factor 1	Homo sapiens	179-183
21272566-1	2011	A sensitive non-radioactive method for determination of the stereospecificity of the C-4" hydrogen transfer on the coenzymes (pyridoxal phosphate, PLP; and pyridoxamine phosphate, PMP) of aminotransferases has been developed.	Hydrogen	90-98	proteolipid protein 1	Homo sapiens	147-150
21272566-5	2011	The (2)H at C-4" is retained with the PLP if the aminotransferase in question transfers C-4" hydrogen on the opposite face of the coenzyme compared with the reference aminotransferase, but the (2)H is removed if the test and reference aminotransferases catalyze hydrogen transfer on the same face.	Hydrogen	93-101	proteolipid protein 1	Homo sapiens	38-41
21272566-5	2011	The (2)H at C-4" is retained with the PLP if the aminotransferase in question transfers C-4" hydrogen on the opposite face of the coenzyme compared with the reference aminotransferase, but the (2)H is removed if the test and reference aminotransferases catalyze hydrogen transfer on the same face.	Hydrogen	262-270	proteolipid protein 1	Homo sapiens	38-41
15033987-7	2004	Furthermore, co-immunoprecipitation of RyR1 with 33 various mutants for the 9 positions produced by introducing different size, charge, and hydrophobicity revealed that an integration of the hydrogen bonds by the irreplaceable Gln-3 and the hydrophobic interactions by the residues Arg-18 and Met-49 could be a possible mechanism for the binding of FKBP12 to RyR1.	Hydrogen	191-199	ryanodine receptor 1	Oryctolagus cuniculus	359-363
21319242-4	2011	The molecular structure of [PdCl(2)(1H OCH(3))] was determined crystallographically and revealed that the reaction with methanol proceeds selectively by syn addition and exclusively to one of the P=C double bonds.	Hydrogen	36-38	synemin	Homo sapiens	153-156
15158803-5	2004	These findings are interpreted as three binding subsites in the GABA receptor: a hydrophobic site undergoing steric interaction with the tert-butyl or equivalent group; a hydrogen bonding site to pyrazole N-2; a pi bonding site to the face of the phenyl moiety; with supplemental enhancement by the 3-cyano and 4-ethynyl substituents.	Hydrogen	171-179	GABA type A receptor-associated protein	Homo sapiens	64-77
21158455-7	2011	In methyl beta-maltoside, competition between HO2"-O3 intramolecular hydrogen bonding and intermolecular hydrogen bonding of those groups with solvent leads to increased sampling of syn, anti-phi, and anti-psi conformations and better agreement with NMR J-coupling constants.	Hydrogen	69-77	synemin	Homo sapiens	182-185
7430148-8	1980	To accommodate the available evidence on Site 2 substrates, it is concluded that the substrate hydrogens are first transferred to ubiquinone, 2 H+ per 2e then appear in the medium by protolytic dehydrogenation of a species of ubiquinol or ubiquinol-protein having the appropriate sidedness (designated Site 2A), and the other 2 H+ are translocated from the matrix to the medium on passage of 2e- through the cytochrome b x c1 complex (designated Site 2B).	Hydrogen	95-104	cytochrome b, mitochondrial	Rattus norvegicus	408-420
21158455-7	2011	In methyl beta-maltoside, competition between HO2"-O3 intramolecular hydrogen bonding and intermolecular hydrogen bonding of those groups with solvent leads to increased sampling of syn, anti-phi, and anti-psi conformations and better agreement with NMR J-coupling constants.	Hydrogen	105-113	synemin	Homo sapiens	182-185
15195308-1	2004	Hydrogen abstraction from 2-aminoethanol by the 5"-deoxyadenosyl radical, which is formed upon Co--C bond homolysis in coenzyme B(12), was investigated by theoretical means with employment of the DFT (B3LYP) and ab initio (MP2) approaches.	Hydrogen	0-8	tryptase pseudogene 1	Homo sapiens	223-226
21523067-3	2011	Pairs of mol-ecules assemble in the crystal structure, forming centrosymmetric hydrogen-bonded dimers via pairs of N-H N hydrogen bonds through the syn H atom of the amine group.	Hydrogen	79-87	synemin	Homo sapiens	148-151
21523067-3	2011	Pairs of mol-ecules assemble in the crystal structure, forming centrosymmetric hydrogen-bonded dimers via pairs of N-H N hydrogen bonds through the syn H atom of the amine group.	Hydrogen	121-129	synemin	Homo sapiens	148-151
15213241-0	2004	Mass spectrometry on hydrogen/deuterium exchange of dihydrofolate reductase: effects of ligand binding.	Hydrogen	21-29	Dihydrofolate reductase	Escherichia coli	52-75
6774978-6	1980	The structures of the remaining two oligosaccharides F2 and H2 were elucidated as GlcNAc beta 1-2Man alpha 1-(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-)GlcNAc and Man alpha 1-(Man alpha 1-)Man beta 1-(GlcNAc beta 1-Man alpha 1-)Man beta 1-GlcNAc beta 1-GlcNAc, respectively.	Hydrogen	60-62	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	89-97
6774978-6	1980	The structures of the remaining two oligosaccharides F2 and H2 were elucidated as GlcNAc beta 1-2Man alpha 1-(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-)GlcNAc and Man alpha 1-(Man alpha 1-)Man beta 1-(GlcNAc beta 1-Man alpha 1-)Man beta 1-GlcNAc beta 1-GlcNAc, respectively.	Hydrogen	60-62	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	89-95
6774978-6	1980	The structures of the remaining two oligosaccharides F2 and H2 were elucidated as GlcNAc beta 1-2Man alpha 1-(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-)GlcNAc and Man alpha 1-(Man alpha 1-)Man beta 1-(GlcNAc beta 1-Man alpha 1-)Man beta 1-GlcNAc beta 1-GlcNAc, respectively.	Hydrogen	60-62	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	117-123
6774978-6	1980	The structures of the remaining two oligosaccharides F2 and H2 were elucidated as GlcNAc beta 1-2Man alpha 1-(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-)GlcNAc and Man alpha 1-(Man alpha 1-)Man beta 1-(GlcNAc beta 1-Man alpha 1-)Man beta 1-GlcNAc beta 1-GlcNAc, respectively.	Hydrogen	60-62	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	117-123
6774978-6	1980	The structures of the remaining two oligosaccharides F2 and H2 were elucidated as GlcNAc beta 1-2Man alpha 1-(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-)GlcNAc and Man alpha 1-(Man alpha 1-)Man beta 1-(GlcNAc beta 1-Man alpha 1-)Man beta 1-GlcNAc beta 1-GlcNAc, respectively.	Hydrogen	60-62	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	117-123
6774978-6	1980	The structures of the remaining two oligosaccharides F2 and H2 were elucidated as GlcNAc beta 1-2Man alpha 1-(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-)GlcNAc and Man alpha 1-(Man alpha 1-)Man beta 1-(GlcNAc beta 1-Man alpha 1-)Man beta 1-GlcNAc beta 1-GlcNAc, respectively.	Hydrogen	60-62	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	117-123
6774978-6	1980	The structures of the remaining two oligosaccharides F2 and H2 were elucidated as GlcNAc beta 1-2Man alpha 1-(GlcNAc beta 1-2Man alpha 1-3)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-)GlcNAc and Man alpha 1-(Man alpha 1-)Man beta 1-(GlcNAc beta 1-Man alpha 1-)Man beta 1-GlcNAc beta 1-GlcNAc, respectively.	Hydrogen	60-62	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	117-123
21220114-4	2011	Hydrogen/deuterium exchange (HDX) data indicate that the CAR activation function 2 (AF-2) is more stable in CAR(TCPOBOP):RXR and CAR(meclizine):RXR than in CAR:RXR.	Hydrogen	0-8	nuclear receptor subfamily 1 group I member 3	Homo sapiens	57-60
21220114-4	2011	Hydrogen/deuterium exchange (HDX) data indicate that the CAR activation function 2 (AF-2) is more stable in CAR(TCPOBOP):RXR and CAR(meclizine):RXR than in CAR:RXR.	Hydrogen	0-8	nuclear receptor subfamily 1 group I member 3	Homo sapiens	108-111
21220114-4	2011	Hydrogen/deuterium exchange (HDX) data indicate that the CAR activation function 2 (AF-2) is more stable in CAR(TCPOBOP):RXR and CAR(meclizine):RXR than in CAR:RXR.	Hydrogen	0-8	retinoid X receptor alpha	Homo sapiens	121-124
21220114-4	2011	Hydrogen/deuterium exchange (HDX) data indicate that the CAR activation function 2 (AF-2) is more stable in CAR(TCPOBOP):RXR and CAR(meclizine):RXR than in CAR:RXR.	Hydrogen	0-8	nuclear receptor subfamily 1 group I member 3	Homo sapiens	108-111
21220114-4	2011	Hydrogen/deuterium exchange (HDX) data indicate that the CAR activation function 2 (AF-2) is more stable in CAR(TCPOBOP):RXR and CAR(meclizine):RXR than in CAR:RXR.	Hydrogen	0-8	nuclear receptor subfamily 1 group I member 3	Homo sapiens	108-111
15147687-4	2004	The shifts of nu(C=O) of MHB in ethanol/CCl4 binary solvents showed that several kinds of solute-solvent hydrogen bonding interactions coexisted in the mixture solvents, with a change in the mole fraction of ethanol in the binary solvents.	Hydrogen	105-113	C-C motif chemokine ligand 4	Homo sapiens	40-44
21155690-11	2011	Common features of all of them include a hydrogen bond donor-acceptor pair that makes contact with the backbone CO- and NH- bonds of Arg 63 residue on GK and two hydrophobic groups.	Hydrogen	41-49	glucokinase	Homo sapiens	151-153
21931800-9	2011	Hydrogen bonding analysis suggests that the interaction between JMJD2A and its substrates mainly comes from main chain-side chain interactions.	Hydrogen	0-8	lysine demethylase 4A	Homo sapiens	64-70
6159647-1	1980	Inhibitors of fatty acid cyclooxygenase 8,11,14-icosatrienoate, hydrogen donor:oxygen oxidoreductase, EC 1.14.99.1) were found to suppress the establishment of the interferon-mediated antiviral state.	Hydrogen	64-72	thioredoxin reductase 1	Homo sapiens	86-100
15103622-5	2004	Three differentiated interaction modes between CD4 and gp120 were found, which involve electrostatics, hydrogen bond and van der Waals networks.	Hydrogen	103-111	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	55-60
21126042-7	2010	Furthermore, in contrast to the results obtained for the SyB(GAF), the MD simulations showed a very stable Cph1 structure where an important hydrogen bond and water network in the chromophore binding pocket could be identified.	Hydrogen	141-149	fibroblast growth factor 9	Homo sapiens	61-64
14752117-8	2004	The C1" of the modeled donor mannose is within hydrogen-bonding distance of both the hydroxyl of Tyr(220) and the O2 of the acceptor mannose.	Hydrogen	47-55	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	4-7
20869434-1	2010	Drosophila mitochondria contain two peroxidases, peroxiredoxin 3 (dPrx3) and peroxiredoxin 5 (dPrx5), which together constitute the sole known intramitochondrial mechanism for the catalytic removal of hydrogen and organic peroxides.	Hydrogen	201-209	Peroxiredoxin 5	Drosophila melanogaster	77-92
20869434-1	2010	Drosophila mitochondria contain two peroxidases, peroxiredoxin 3 (dPrx3) and peroxiredoxin 5 (dPrx5), which together constitute the sole known intramitochondrial mechanism for the catalytic removal of hydrogen and organic peroxides.	Hydrogen	201-209	Peroxiredoxin 5	Drosophila melanogaster	94-99
14872136-0	2004	1H, 13C and 15N resonance assignments of human RGSZ1.	Hydrogen	0-2	regulator of G protein signaling 20	Homo sapiens	47-52
14872137-0	2004	Assignment of the 1H, 13C, and 15N resonances of the AXH domain of the transcription factor HBP1.	Hydrogen	18-20	HMG-box transcription factor 1	Homo sapiens	92-96
20920557-3	2010	ISA potently inhibited protein translation, and induced a slow but prolonged activation of the stress-activated protein kinases, JNK and p38, at between 1h and 6h after treatment.	Hydrogen	153-155	annexin A13	Homo sapiens	0-3
15020763-3	2004	The glutamate at P6, which is formed by tissue transglutaminase-catalyzed deamidation, is an important anchor residue as it participates in an extensive hydrogen-bonding network involving Lys-beta71 of DQ2.	Hydrogen	153-161	torsin family 1 member A	Homo sapiens	202-205
20839296-7	2010	For cytochrome c, cytochrome b(562) and triosephophate isomerase, independent folding units have been determined on the basis of hydrogen exchange experiments and misincorporation proton-alkyl exchange experiments.	Hydrogen	129-137	mitochondrially encoded cytochrome b	Homo sapiens	18-30
21113965-4	2010	Docking of compound 2e into PPARdelta revealed that it occupied the agonist binding site and exhibited key hydrogen bonding interactions with His323, His449, and Tyr473.	Hydrogen	107-115	peroxisome proliferator activated receptor delta	Homo sapiens	28-37
15020763-4	2004	The gluten peptide-DQ2 complex retains critical hydrogen bonds between the MHC and the peptide backbone despite the presence of many proline residues in the peptide that are unable to participate in amide-mediated hydrogen bonds.	Hydrogen	48-56	torsin family 1 member A	Homo sapiens	19-22
15020763-4	2004	The gluten peptide-DQ2 complex retains critical hydrogen bonds between the MHC and the peptide backbone despite the presence of many proline residues in the peptide that are unable to participate in amide-mediated hydrogen bonds.	Hydrogen	214-222	torsin family 1 member A	Homo sapiens	19-22
14638688-1	2004	Comparison of the architecture around the active site of soybean beta-amylase and Bacillus cereus beta-amylase showed that the hydrogen bond networks (Glu380-(Lys295-Met51) and Glu380-Asn340-Glu178) in soybean beta-amylase around the base catalytic residue, Glu380, seem to contribute to the lower pH optimum of soybean beta-amylase.	Hydrogen	127-135	beta-amylase	Glycine max	65-77
20675355-5	2010	Importantly, the aptamer-hFc1 interaction involves mainly van der Waals contacts and hydrogen bonds rather than electrostatic forces, in contrast to other known aptamer-protein complexes.	Hydrogen	85-93	host cell factor C1	Homo sapiens	25-29
14638688-1	2004	Comparison of the architecture around the active site of soybean beta-amylase and Bacillus cereus beta-amylase showed that the hydrogen bond networks (Glu380-(Lys295-Met51) and Glu380-Asn340-Glu178) in soybean beta-amylase around the base catalytic residue, Glu380, seem to contribute to the lower pH optimum of soybean beta-amylase.	Hydrogen	127-135	beta-amylase	Glycine max	98-110
14638688-1	2004	Comparison of the architecture around the active site of soybean beta-amylase and Bacillus cereus beta-amylase showed that the hydrogen bond networks (Glu380-(Lys295-Met51) and Glu380-Asn340-Glu178) in soybean beta-amylase around the base catalytic residue, Glu380, seem to contribute to the lower pH optimum of soybean beta-amylase.	Hydrogen	127-135	beta-amylase	Glycine max	98-110
20732329-4	2010	In this work, we used hydrogen-deuterium exchange and mass spectrometry to gain insight into the structural properties of exRAGE (extracellular region of RAGE)--the full extracellular part of the protein.	Hydrogen	22-30	advanced glycosylation end-product specific receptor	Homo sapiens	124-128
20947009-1	2010	The dynamic properties of VDR LBD and full-length VDR/RXRalpha heterodimer in the presence and absence of ligands were investigated by hydrogen/deuterium exchange mass spectrometry (Zhang et al., 2010a).	Hydrogen	135-143	vitamin D receptor	Homo sapiens	26-29
20947021-0	2010	Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer.	Hydrogen	0-8	vitamin D receptor	Homo sapiens	94-112
20947021-0	2010	Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer.	Hydrogen	0-8	retinoid X receptor alpha	Homo sapiens	113-132
14638688-1	2004	Comparison of the architecture around the active site of soybean beta-amylase and Bacillus cereus beta-amylase showed that the hydrogen bond networks (Glu380-(Lys295-Met51) and Glu380-Asn340-Glu178) in soybean beta-amylase around the base catalytic residue, Glu380, seem to contribute to the lower pH optimum of soybean beta-amylase.	Hydrogen	127-135	beta-amylase	Glycine max	98-110
14999005-0	2004	Mass spectrometry on segment-specific hydrogen exchange of dihydrofolate reductase.	Hydrogen	38-46	Dihydrofolate reductase	Escherichia coli	59-82
21085509-3	2010	Previously, in our group, amino acid based amphiphiles i.e. Gly-Gly-His-EO2-Alk, a trimodular amphiphile (containing three domains: H-bond donor and acceptor/hydrophilic/hydrophobic domain, respectively) were reported to act as hydrogelators and that the gelation properties were related to hydrogen bonding, hydrophobic interactions and pi-pi stacking.	Hydrogen	291-299	ALK receptor tyrosine kinase	Homo sapiens	76-79
14664608-0	2003	True stabilization energies for the optimal planar hydrogen-bonded and stacked structures of guanine...cytosine, adenine...thymine, and their 9- and 1-methyl derivatives: complete basis set calculations at the MP2 and CCSD(T) levels and comparison with experiment.	Hydrogen	51-59	tryptase pseudogene 1	Homo sapiens	210-213
21166641-2	2010	TBP bind to DNA by covalent phosphotriester and noncovalent ionic and hydrogen bonds.	Hydrogen	70-78	TATA-box binding protein	Homo sapiens	0-3
20617401-0	2010	1H, 13C, and 15N resonance assignments of the N-terminal domain of human Tubulin Binding Cofactor C.	Hydrogen	0-2	tubulin folding cofactor C	Homo sapiens	89-99
14606911-3	2003	The structures of the block copolymer and its precursors from the initial step of PCL were confirmed and investigated by 1H NMR, FT-IR, GPC, and FT-ICRMS analyses and DSC measurements.	Hydrogen	121-123	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	82-85
20703836-0	2010	1H, 15N and 13C resonance assignment of darcin, a mouse major urinary protein.	Hydrogen	0-2	major urinary protein 20	Mus musculus	40-46
12975585-0	2003	Assignment of 1H, 13C and 15N resonances of the ARID domain of P270.	Hydrogen	14-16	AT-rich interaction domain 1A	Homo sapiens	63-67
20812715-3	2010	Simulations suggest that the Watson-Crick base-pairing between G8 and C3, the hydrogen bond network between C17 and G5, and the base stacking interactions between G8 and C1.1, collectively, are key to maintaining an active site structure conducive for catalytic activity.	Hydrogen	78-86	aldo-keto reductase family 1 member C4	Homo sapiens	170-174
21587422-2	2010	The hy-droxy unit of the neutral ligand is a hydrogen-bond donor to the methanol O atom and the alk-oxy O atom of the monoanionic ligand is a hydrogen-bond acceptor to the methanol O atom.	Hydrogen	142-150	ALK receptor tyrosine kinase	Homo sapiens	96-99
12975590-0	2003	1H, 15N and 13C chemical shift assignments of the Pleckstrin Homology domain of the Human Protein Kinase B (PKB/Akt).	Hydrogen	0-2	protein tyrosine kinase 2 beta	Homo sapiens	90-106
12975590-0	2003	1H, 15N and 13C chemical shift assignments of the Pleckstrin Homology domain of the Human Protein Kinase B (PKB/Akt).	Hydrogen	0-2	protein tyrosine kinase 2 beta	Homo sapiens	108-111
12898687-9	2003	Nevertheless, glucose is an efficient electron donor that transfers hydride through the hexose monophosphate (HMP) pathway in which the main hydrogen source is C-1 and C-3 hydrogen of glucose.	Hydrogen	141-149	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	160-171
20623055-3	2010	In the presence of water, the hydrogen migration occurs via a six-membered ring transition state and the corresponding energy barrier decreases dramatically, and therefore the RDS is the C-C bond formation step.	Hydrogen	30-38	peripherin 2	Homo sapiens	176-179
20571679-3	2010	The two beta-hairpin peptides studied here and the GB1 studied previously display three different denaturant processes in urea solution by which the breaking of backbone native hydrogen bonds takes different orders.	Hydrogen	177-185	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	51-54
12898687-9	2003	Nevertheless, glucose is an efficient electron donor that transfers hydride through the hexose monophosphate (HMP) pathway in which the main hydrogen source is C-1 and C-3 hydrogen of glucose.	Hydrogen	172-180	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	160-171
14503974-1	2003	Thioredoxin (Trx) and glutaredoxin (Grx) are dithiol redox enzymes, catalyzing general thiol-disulfide oxidoreductions apart from being hydrogen donors for ribonucleotide reductase, an enzyme essential for DNA synthesis.	Hydrogen	136-144	thioredoxin	Homo sapiens	0-11
20596557-1	2010	Construction of a 3-D supramolecular network from [Ln(cpb)(3)(H(2)O)(2)] (Ln = Nd, Tb; Hcpb = 1-(4-cyanophenyl)-1,3-butanedione) by sequential displacement of a coordinated water by DMF, dimerisation by reciprocal hydrogen bonding in solution and pi-pi stacking and interdigitation of nitriles has been monitored by in situ fourier transform infrared spectroscopy.	Hydrogen	214-222	carboxypeptidase B1	Homo sapiens	54-57
14503974-1	2003	Thioredoxin (Trx) and glutaredoxin (Grx) are dithiol redox enzymes, catalyzing general thiol-disulfide oxidoreductions apart from being hydrogen donors for ribonucleotide reductase, an enzyme essential for DNA synthesis.	Hydrogen	136-144	thioredoxin	Homo sapiens	13-16
20698653-0	2010	13CHD2 methyl group probes of millisecond time scale exchange in proteins by 1H relaxation dispersion: an application to proteasome gating residue dynamics.	Hydrogen	77-79	chromodomain helicase DNA binding protein 2	Homo sapiens	2-6
12815266-0	2003	Backbone 1H, 13C and 15N resonance assignments for the 25.8 kDa DNA binding domain of the human p63 protein.	Hydrogen	9-11	tumor protein p63	Homo sapiens	96-99
15369364-7	2003	The catalytic effects of Sc(OTf)(3) (OTf = triflate) on the electron-transfer reactions are compared with those of Sc(OTf)(3) on the hydrogen- and oxygen-transfer reactions.	Hydrogen	133-141	POU class 5 homeobox 1	Homo sapiens	115-124
20808434-3	2010	To understand this, comprehensive analysis of hydrophobic interactions, hydrogen bonding and binding affinity have been analyzed at the interface of c-Src and c-Abl kinases and 4-amino substituted 1H-pyrazolo [3, 4-d] pyrimidine compounds.	Hydrogen	72-80	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	159-164
20423721-10	2010	This effect of hydrogen was accompanied by a reduction of the expression of 8OHG, HNE, and nitrotyrosine and the activity of MMP-9.	Hydrogen	15-23	matrix metallopeptidase 9	Rattus norvegicus	125-130
12861080-0	2003	Myoglobin: the hydrogen atom of biology and a paradigm of complexity.	Hydrogen	15-23	myoglobin	Homo sapiens	0-9
20693691-7	2010	Firstly, TEI-9647 forms hydrogen bonds to His305, which promote conformational changes in hVDR and draw Cys403 or Cys410 towards the ligand.	Hydrogen	24-32	vitamin D receptor	Homo sapiens	90-94
20305288-3	2010	The intestinal infusion of TCA into the CBF rat rapidly (1h) activated the AKT (approximately 9-fold) and ERK1/2 (3- to 5-fold) signaling pathways, downregulated (approximately 50%, 30 min) the mRNA levels of PEPCK and G-6-Pase, and induced (14-fold in 3 h) SHP mRNA.	Hydrogen	57-59	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	209-214
12850140-10	2003	Opening results in breakage of the H3(U)-O6(G/6MI) hydrogen bond, and distortion of the H1(G/6MI)-O2(U) hydrogen bond.	Hydrogen	104-112	H1.5 linker histone, cluster member	Homo sapiens	88-96
20599761-3	2010	The inhibitor binds exclusively in the S(1) and S(2) binding pockets of AnCE (coordinating the zinc ion) through ionic and hydrogen bond interactions.	Hydrogen	123-131	Angiotensin converting enzyme	Drosophila melanogaster	72-76
20550179-3	2010	The additional electron-density transfer from the three lone electron pairs on the halogen atom to the remote part of the halogen atom donor (i.e., the antibonding orbitals of the bonds other than X-Hal) makes the blue-shifting halogen bond much more ubiquitous in the halogen-bonded complexes than the blue-shifitng hydrogen bond in the hydrogen-bonded complexes, and it also makes the values of the X-Hal bond contraction generally much larger than the values of the X-H bond contraction.	Hydrogen	317-325	histidine ammonia-lyase	Homo sapiens	199-202
20550179-3	2010	The additional electron-density transfer from the three lone electron pairs on the halogen atom to the remote part of the halogen atom donor (i.e., the antibonding orbitals of the bonds other than X-Hal) makes the blue-shifting halogen bond much more ubiquitous in the halogen-bonded complexes than the blue-shifitng hydrogen bond in the hydrogen-bonded complexes, and it also makes the values of the X-Hal bond contraction generally much larger than the values of the X-H bond contraction.	Hydrogen	317-325	histidine ammonia-lyase	Homo sapiens	403-406
20550179-3	2010	The additional electron-density transfer from the three lone electron pairs on the halogen atom to the remote part of the halogen atom donor (i.e., the antibonding orbitals of the bonds other than X-Hal) makes the blue-shifting halogen bond much more ubiquitous in the halogen-bonded complexes than the blue-shifitng hydrogen bond in the hydrogen-bonded complexes, and it also makes the values of the X-Hal bond contraction generally much larger than the values of the X-H bond contraction.	Hydrogen	338-346	histidine ammonia-lyase	Homo sapiens	199-202
12814975-2	2003	The CYP2C9 pharmacophore is proposed to include either an anionic group or hydrogen bond donor in addition to its hydrophobic groups.	Hydrogen	75-83	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	4-10
20550179-3	2010	The additional electron-density transfer from the three lone electron pairs on the halogen atom to the remote part of the halogen atom donor (i.e., the antibonding orbitals of the bonds other than X-Hal) makes the blue-shifting halogen bond much more ubiquitous in the halogen-bonded complexes than the blue-shifitng hydrogen bond in the hydrogen-bonded complexes, and it also makes the values of the X-Hal bond contraction generally much larger than the values of the X-H bond contraction.	Hydrogen	338-346	histidine ammonia-lyase	Homo sapiens	403-406
12819771-5	2003	Differences in hydrogen bonding between the MeLys epsilon-amino group and Rubisco LSMT and SET7/9 explain why Rubisco LSMT generates multiply methylated Lys, wheras SET7/9 generates only MeLys.	Hydrogen	15-23	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	91-97
20435140-3	2010	The X-ray crystal structure of human VDR in complex with 1alpha,25-dihydroxyvitamin D3 (1) shows that, together with Ser-237, the 1alpha-hydroxyl group of 1alpha,25-dihydroxyvitamin D3 (1) makes hydrogen bonds with Arg-274, single mutation of which results in impaired ligand recognition.	Hydrogen	195-203	vitamin D receptor	Homo sapiens	37-40
7192272-0	1980	Biofunctional evaluation of a hydrogen bond stabilizing the beta-turn in the acyclic part of oxytocin.	Hydrogen	30-38	oxytocin/neurophysin I prepropeptide	Homo sapiens	93-101
12819771-5	2003	Differences in hydrogen bonding between the MeLys epsilon-amino group and Rubisco LSMT and SET7/9 explain why Rubisco LSMT generates multiply methylated Lys, wheras SET7/9 generates only MeLys.	Hydrogen	15-23	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	165-171
116677-6	1979	On the basis of these studies, it is suggested that hydrogen bonding occurs between the hydrogen atoms of the C-3 and C-4 hydroxyl groups of alpha-D-GalNAcp and alpha-D-galp units and the A and B subunits, respectively.	Hydrogen	52-60	complement C3	Homo sapiens	110-113
116677-6	1979	On the basis of these studies, it is suggested that hydrogen bonding occurs between the hydrogen atoms of the C-3 and C-4 hydroxyl groups of alpha-D-GalNAcp and alpha-D-galp units and the A and B subunits, respectively.	Hydrogen	88-96	complement C3	Homo sapiens	110-113
20383409-0	2010	Solar hydrogen production over novel metal sulfide photocatalysts of AGa2In3S8 (A = Cu or Ag) with layered structures.	Hydrogen	6-14	AGA2	Homo sapiens	69-73
12766414-0	2003	1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein.	Hydrogen	0-2	LDL receptor related protein associated protein 1	Homo sapiens	53-80
20197780-3	2010	Increased plasma MMP-9 was associated with BCSFB disruption at 1h post-reperfusion.	Hydrogen	63-65	matrix metallopeptidase 9	Homo sapiens	17-22
12739977-1	2003	Inter- and intramolecular hydrogen bonding of an N-H group in pyrazole complexes was studied using ligands with two different groups at pyrazole C-3 and C-5.	Hydrogen	26-34	complement C5	Homo sapiens	153-156
20013135-3	2010	Based on systematic examination of hydrogen bond breaking and classical MD/molecular mechanics-generalized Born/surface area) (MM-GBSA) calculations, a CDK5 activation mechanism by p25 is suggested.	Hydrogen	35-43	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	181-184
20689681-10	2010	The phosphate oxygens OP1 or OP2 are used as hydrogen bond acceptors in 12% of all nucleotides, and the ribose ring oxygen O4" and phosphodiester oxygens O3" and O5" are used in 4%, 4%, and 1% of all nucleotides, respectively.	Hydrogen	45-53	bone morphogenetic protein 7	Homo sapiens	22-25
226358-0	1979	Conformation and flexibility of GpC and CpG in neutral aqueous solution using 1H nuclear-magnetic-resonance and spin-lattice-relaxation time measurements.	Hydrogen	78-80	glycophorin C (Gerbich blood group)	Homo sapiens	32-35
447726-3	1979	In the reaction of L-tryptophan methyl ester, the enzyme also catalyzes stereospecific removal of the pro-S hydrogen at C-3, but the product 3-hydroxytryptophan methyl ester is racemic at C-3.	Hydrogen	108-116	complement C3	Homo sapiens	120-123
447726-3	1979	In the reaction of L-tryptophan methyl ester, the enzyme also catalyzes stereospecific removal of the pro-S hydrogen at C-3, but the product 3-hydroxytryptophan methyl ester is racemic at C-3.	Hydrogen	108-116	complement C3	Homo sapiens	188-191
447726-4	1979	The unreacted tryptophan methyl ester is shown to incorporate solvent hydrogen into the pro-S position at C-3 in an at least partially stereospecific manner, suggesting that the reaction of L-tryptophan methyl ester is reversible.	Hydrogen	70-78	complement C3	Homo sapiens	106-109
12739977-6	2003	In addition, however, intermolecular hydrogen bonding could be controlled by the substituent at C-5: complexes with either a methyl at C-5 or no substituent there showed significant intermolecular hydrogen bonding interactions, which were completely avoided by placing a tert-butyl group at C-5.	Hydrogen	37-45	complement C5	Homo sapiens	96-99
20354153-9	2010	Mutant Arg52Gln analysis shows that electrostatic interaction and hydrogen bonds between RNA and U1A (Arg52Gln) decrease.	Hydrogen	66-74	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	97-100
36890-0	1979	4-Nitro-L-histidine as a substrate for histidine ammonia-lyase: the role of beta-hydrogen acidity in the rate-limiting step.	Hydrogen	81-89	histidine ammonia-lyase	Homo sapiens	39-62
12739977-6	2003	In addition, however, intermolecular hydrogen bonding could be controlled by the substituent at C-5: complexes with either a methyl at C-5 or no substituent there showed significant intermolecular hydrogen bonding interactions, which were completely avoided by placing a tert-butyl group at C-5.	Hydrogen	37-45	complement C5	Homo sapiens	135-138
12739977-6	2003	In addition, however, intermolecular hydrogen bonding could be controlled by the substituent at C-5: complexes with either a methyl at C-5 or no substituent there showed significant intermolecular hydrogen bonding interactions, which were completely avoided by placing a tert-butyl group at C-5.	Hydrogen	37-45	complement C5	Homo sapiens	135-138
20171955-1	2010	This study is to examine if hydrogen-rich saline reduced amyloid beta (Abeta) induced neural inflammation, and learning and memory deficits in a rat model.	Hydrogen	28-36	amyloid beta precursor protein	Rattus norvegicus	71-76
12739977-6	2003	In addition, however, intermolecular hydrogen bonding could be controlled by the substituent at C-5: complexes with either a methyl at C-5 or no substituent there showed significant intermolecular hydrogen bonding interactions, which were completely avoided by placing a tert-butyl group at C-5.	Hydrogen	197-205	complement C5	Homo sapiens	96-99
20171955-9	2010	Furthermore, hydrogen-rich saline treatment also decreased the immunoreactivitiy of HNE and GFAP in hippocampus induced by Abeta1-42.	Hydrogen	13-21	glial fibrillary acidic protein	Rattus norvegicus	92-96
12739977-6	2003	In addition, however, intermolecular hydrogen bonding could be controlled by the substituent at C-5: complexes with either a methyl at C-5 or no substituent there showed significant intermolecular hydrogen bonding interactions, which were completely avoided by placing a tert-butyl group at C-5.	Hydrogen	197-205	complement C5	Homo sapiens	135-138
12739977-6	2003	In addition, however, intermolecular hydrogen bonding could be controlled by the substituent at C-5: complexes with either a methyl at C-5 or no substituent there showed significant intermolecular hydrogen bonding interactions, which were completely avoided by placing a tert-butyl group at C-5.	Hydrogen	197-205	complement C5	Homo sapiens	135-138
12712243-11	2003	These findings are in good agreement with the crystal structure in which R263 makes hydrogen bonds with phosphorus atoms of DNA backbone to mediate the stable binding of HNF-1alpha homeodomain to the promoter.	Hydrogen	84-92	HNF1 homeobox A	Mus musculus	170-180
20302307-5	2010	Our calculations also show that the difference in binding free energy of avidin to BTN1 and BTN2 is almost entirely due to the contribution of electrostatic interaction resulting from polarization-induced stabilization of a hydrogen bond between avidin and BTN1.	Hydrogen	224-232	butyrophilin subfamily 1 member A1	Homo sapiens	83-87
20302307-5	2010	Our calculations also show that the difference in binding free energy of avidin to BTN1 and BTN2 is almost entirely due to the contribution of electrostatic interaction resulting from polarization-induced stabilization of a hydrogen bond between avidin and BTN1.	Hydrogen	224-232	butyrophilin subfamily 1 member A1	Homo sapiens	257-261
718851-0	1978	Conformational studies on [Pro3, Gly4]-oxytocin in dimethyl sulfoxide by 1H nuclear magnetic resonance spectroscopy: evidence for a type II beta turn in the cyclic moiety.	Hydrogen	73-75	pyrroline-5-carboxylate reductase 1	Homo sapiens	27-31
12682395-2	2003	An intramolecular N1-H1.Cl1 hydrogen bond contributes to the adopted conformation and may additionally participate in secondary interactions with substrates during catalysis.	Hydrogen	28-36	adhesion G protein-coupled receptor L1	Homo sapiens	24-27
668078-5	1978	During Re-HPS showing a LBBB pattern, the retrograde activation of the His bundle (H2) in response to V2 occurred via the left bundle branch (LBB), as indicated by inscription of retrograde H2 prior to RB2 in nine of 13 cases (average H2-RB2 = 9.4 msec), and simultaneous incription of retrograde H2 and RB2 in the remaining four.	Hydrogen	83-85	RB transcriptional corepressor like 2	Homo sapiens	202-205
668078-5	1978	During Re-HPS showing a LBBB pattern, the retrograde activation of the His bundle (H2) in response to V2 occurred via the left bundle branch (LBB), as indicated by inscription of retrograde H2 prior to RB2 in nine of 13 cases (average H2-RB2 = 9.4 msec), and simultaneous incription of retrograde H2 and RB2 in the remaining four.	Hydrogen	83-85	RB transcriptional corepressor like 2	Homo sapiens	238-241
668078-5	1978	During Re-HPS showing a LBBB pattern, the retrograde activation of the His bundle (H2) in response to V2 occurred via the left bundle branch (LBB), as indicated by inscription of retrograde H2 prior to RB2 in nine of 13 cases (average H2-RB2 = 9.4 msec), and simultaneous incription of retrograde H2 and RB2 in the remaining four.	Hydrogen	83-85	RB transcriptional corepressor like 2	Homo sapiens	238-241
668078-6	1978	When V3 showed a RBBB pattern the retrograde RB2 preceded H2, suggesting H2 activation via the RBB.	Hydrogen	73-75	RB transcriptional corepressor like 2	Homo sapiens	45-48
20449448-3	2010	In all of these compounds, the L(1)or L(2) anion ligands are in a syn, syn, syn orientation which result in a bowl-like cavity that can serve as a host to bind the methyl of a solvent CH(3)CN within the naphthanoimidazolate or benzoimidazolate-built cavity through C-H...pi hydrogen bonds in the crystal state.	Hydrogen	274-282	synemin	Homo sapiens	66-69
20449448-3	2010	In all of these compounds, the L(1)or L(2) anion ligands are in a syn, syn, syn orientation which result in a bowl-like cavity that can serve as a host to bind the methyl of a solvent CH(3)CN within the naphthanoimidazolate or benzoimidazolate-built cavity through C-H...pi hydrogen bonds in the crystal state.	Hydrogen	274-282	synemin	Homo sapiens	71-74
20449448-3	2010	In all of these compounds, the L(1)or L(2) anion ligands are in a syn, syn, syn orientation which result in a bowl-like cavity that can serve as a host to bind the methyl of a solvent CH(3)CN within the naphthanoimidazolate or benzoimidazolate-built cavity through C-H...pi hydrogen bonds in the crystal state.	Hydrogen	274-282	synemin	Homo sapiens	71-74
20199107-7	2010	This includes a bidentate hydrogen bonding pattern between PEPA and N754 of the flop isoforms of GluA2 and GluA3 (the corresponding position in the flip isoform is S754).	Hydrogen	26-34	carnosine dipeptidase 2	Homo sapiens	59-63
12679021-1	2003	The structure of [113Cd(7)]-metallothionein (MT_nc) of the Antarctic fish Notothenia coriiceps, the first three-dimensional structure of a fish metallothionein, was determined by homonuclear 1H NMR experiments and heteronuclear [1H, 113Cd]-correlation spectroscopy.	Hydrogen	191-193	enolase-phosphatase 1	Homo sapiens	45-50
20368803-10	2010	This hydrophobic contact is encircled by several hydrogen bonds between the SKIP peptide and PPIL1.	Hydrogen	49-57	peptidylprolyl isomerase like 1	Homo sapiens	93-98
974086-13	1976	The H-2 proton of 1-N6-ethenoadenosine 5"-diphosphate, an analogue of ADP with the 1-nitrogen and 6-nitrogen blocked from potentially hydrogen bonding, still exhibits a large NOE in the nucleotide-enzyme complex.	Hydrogen	134-142	relaxin 2	Homo sapiens	4-7
19916060-0	2010	Backbone and side-chain 1H, 13C and 15N assignments of the ubiquitin-associated domain of human X-linked inhibitor of apoptosis protein.	Hydrogen	24-26	X-linked inhibitor of apoptosis	Homo sapiens	96-135
12679021-1	2003	The structure of [113Cd(7)]-metallothionein (MT_nc) of the Antarctic fish Notothenia coriiceps, the first three-dimensional structure of a fish metallothionein, was determined by homonuclear 1H NMR experiments and heteronuclear [1H, 113Cd]-correlation spectroscopy.	Hydrogen	229-231	enolase-phosphatase 1	Homo sapiens	45-50
19936968-0	2010	Backbone and side chain 1H, 15N and 13C assignments for the oxidised and reduced forms of the oxidoreductase protein DsbA from Staphylococcus aureus.	Hydrogen	24-26	AT695_RS02795	Staphylococcus aureus	94-108
12609744-7	2003	Furthermore, when H(2)O(2) (0.5 to 2 mM) was added to BAECs in static culture, the ECE-1 as well as ET-1 mRNA expression was attenuated in proportion to the concentration of H(2)O(2).	Hydrogen	18-22	endothelin converting enzyme 1	Homo sapiens	83-88
20013162-0	2010	1H, 13C and 15N resonance assignments of the Calmodulin-Munc13-1 peptide complex.	Hydrogen	0-2	unc-13 homolog B	Homo sapiens	56-62
933503-0	1976	The effect of secretin on hydrogen ion transport in the duodenum and jejunum.	Hydrogen	26-34	secretin	Homo sapiens	14-22
12639560-3	2003	The 2-methoxybenzyl compound 1h had approximately 1,000-fold lower IC(50) in NR2B than NR2A-containing cells.	Hydrogen	29-31	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	77-81
1083847-9	1976	Each product can be assigned a precursor radical formed by hydrogen abstraction from C-5, C-4 or C-3 of the ribose-5-phosphate molecule.	Hydrogen	59-67	complement C3	Homo sapiens	97-100
237621-1	1975	The influence of hydrogen ion concentration on binding and conversion of MgATP and CaATP by membrane bound and solubilized ATPase from Escherichia coli has been investigated.	Hydrogen	17-25	ATPase	Escherichia coli	123-129
20100510-6	2010	The hydrogen bond distance between Ser H(gamma)...His N(epsilon2) is more flexible in nature and it varies from 2.0 A to 2.7 A while in the case of His H(delta1)...Asp O(delta1), it is from 1.6A to 2.0 A.	Hydrogen	4-12	delta like canonical Notch ligand 1	Homo sapiens	152-160
20086035-5	2010	Crystallographic analyses of CocE-L169K/G173Q, determined at 1.6-A resolution, suggest that stabilization involves enhanced domain-domain interactions involving van der Waals interactions and hydrogen bonding.	Hydrogen	192-200	carboxylesterase 2H	Mus musculus	29-33
12639560-3	2003	The 2-methoxybenzyl compound 1h had approximately 1,000-fold lower IC(50) in NR2B than NR2A-containing cells.	Hydrogen	29-31	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	87-91
12634929-3	2003	Hydrogen ion block was independent of voltage with K(d) values of 149+/-17.9 nM [H(+)] ( n=6) and 5.76+/-1.23 nM [H(+)] ( n=7) for TASK-1 and -2, respectively.	Hydrogen	0-8	potassium two pore domain channel subfamily K member 3	Homo sapiens	131-144
20201548-3	2010	PGA(Alk) and PGA(Alk+DOX) were assembled via hydrogen bonding with poly(N-vinyl pyrrolidone) (PVPON) on planar and colloidal silica templates.	Hydrogen	45-53	ALK receptor tyrosine kinase	Homo sapiens	17-20
20146531-9	2010	Formation of a complex with intact Hsp70 and Hsp90 or their respective C-terminal octapeptides induced folding of the TPR domain to a defined, highly stabilized structure with protected amide hydrogens.	Hydrogen	192-201	heat shock protein family A (Hsp70) member 4	Homo sapiens	35-40
4644767-0	1972	Relationship between extracellular and intracellular hydrogen ion concentrations and hemoglobin oxygen affinity in the blood of premature infants with RDS.	Hydrogen	53-61	peripherin 2	Homo sapiens	151-154
4973018-0	1967	[Chemolithotrophic growth of Hydrogenomonas H16 in a chemostat with electrolytic production of oxygen and hydrogen].	Hydrogen	106-114	H1.6 linker histone, cluster member	Homo sapiens	44-47
12388109-1	2003	DMT1 (divalent metal transporter 1) is a hydrogen-coupled divalent metal transporter with a substrate preference for iron, although the protein when expressed in frog oocytes transports a broad range of metals, including the toxic metals cadmium and lead.	Hydrogen	41-49	solute carrier family 11 member 2	Homo sapiens	0-4
34038307-8	2021	It was found that in a ternary mixture containing IND, A15 and SSB 55 an increased hydrogen bonding interaction is present, which resulted in improved dissolution performance compared to binary mixtures.	Hydrogen	83-91	immunoglobulin kappa variable 1-32 (pseudogene)	Homo sapiens	55-58
20039720-2	2010	Two rotameric forms, syn and anti, are possible, of which only the former is able to form cyclic hydrogen bonds with protic solvents.	Hydrogen	97-105	synemin	Homo sapiens	21-24
20121272-12	2010	The increase of n(s)(BSA) by an increase in X(Fe) was explained by elongation of mean particle length along with the production of surface hydroxo ions, such as Fe(OH)2+ or Fe(OH)2+, to induce the hydrogen bond between the Fe(III)-substituted Hap surface and BSA molecules, though the number of original C sites established by Ca(II) atoms was reduced.	Hydrogen	197-205	carbonic anhydrase 2	Homo sapiens	327-333
12388109-1	2003	DMT1 (divalent metal transporter 1) is a hydrogen-coupled divalent metal transporter with a substrate preference for iron, although the protein when expressed in frog oocytes transports a broad range of metals, including the toxic metals cadmium and lead.	Hydrogen	41-49	solute carrier family 11 member 2	Homo sapiens	6-34
34002345-5	2021	Second, transient IR continuum absorption (CA) is observed in the region above 1755 cm-1 (CA1) and between 1550 and 1450 cm-1 (CA2), indicative for the IR absorption of highly polarizable protons in hydrogen bonding networks (X-H...Y).	Hydrogen	199-207	carbonic anhydrase 2	Homo sapiens	127-130
12884377-3	2003	The typical orientation of phenethyl group, which has the hydrogen H-6 syn and close to the oxygen of carbonyl C-4, was observed in (-)-(S)-1-acetyl-3-(phenylethyl)-1,3-imidazolidin-4-one but not in the other four compounds; nevertheless, interpretation of chemical shifts based on the ring current effects correlated with the true configuration of the new stereogenic center at C-2.	Hydrogen	58-66	complement C4A (Rodgers blood group)	Homo sapiens	111-114
33989636-9	2021	Molecular dynamics simulations also revealed that hydrogen bond and hydrophobic interactions play a major role in the stability of a modeled TRIM7B30.2-glycogenin-1 C-terminal peptide complex.	Hydrogen	50-58	glycogenin 1	Homo sapiens	152-164
33955747-11	2021	Electrocatalytic hydrogen generation promoted by these three Ni(II) complexes (1.0 mmol) demonstrates an increase in the catalytic current induced by stepwise addition of HOAc (pKa = 22.3 in MeCN) as a proton source.	Hydrogen	17-25	hypoacusis 2 (autosomal recessive)	Homo sapiens	171-175
20058880-2	2010	Here we present the methodology for receptor dynamics characterization of the GPCR human beta(2) adrenergic receptor bound to the inverse agonist carazolol using the technique of amide hydrogen/deuterium exchange coupled with mass spectrometry (HDX MS).	Hydrogen	185-193	adrenoceptor beta 2	Homo sapiens	89-116
20045638-3	2010	X-ray crystallographic studies revealed that high affinity of 19a was due to the hydrophobic interaction arising from better shape complementarity and to the hydrogen bonding network involving the side chain on the tricyclic scaffold.	Hydrogen	158-166	SLAM family member 7	Homo sapiens	62-65
12884377-3	2003	The typical orientation of phenethyl group, which has the hydrogen H-6 syn and close to the oxygen of carbonyl C-4, was observed in (-)-(S)-1-acetyl-3-(phenylethyl)-1,3-imidazolidin-4-one but not in the other four compounds; nevertheless, interpretation of chemical shifts based on the ring current effects correlated with the true configuration of the new stereogenic center at C-2.	Hydrogen	58-66	complement C2	Homo sapiens	379-382
20041691-5	2010	We show that the hydrogen atom abstraction barrier of substrate hydroxylation correlates linearly with the strength of the Fe(III)O-H bond that is formed, i.e., BDE(OH), and that this value ranges by at least 20 kcal mol(-1) dependent on the cis- and trans-ligands attached to the metal.	Hydrogen	17-25	homeobox D13	Homo sapiens	161-164
20041691-7	2010	A general valence bond curve crossing model is set up that explains how the rate constant of hydrogen atom abstraction is proportional to the difference in energy of the C-H bond of the substrate that is broken and the O-H bond of the Fe(III)O-H complex that is formed, i.e., proportional to BDE(CH) - BDE(OH) or the reaction enthalpy.	Hydrogen	93-101	homeobox D13	Homo sapiens	292-295
20041691-7	2010	A general valence bond curve crossing model is set up that explains how the rate constant of hydrogen atom abstraction is proportional to the difference in energy of the C-H bond of the substrate that is broken and the O-H bond of the Fe(III)O-H complex that is formed, i.e., proportional to BDE(CH) - BDE(OH) or the reaction enthalpy.	Hydrogen	93-101	homeobox D13	Homo sapiens	302-305
33600050-1	2021	Mutations in the CLCN5 gene encoding the 2Cl- /1H+ exchanger ClC-5 are associated with Dent disease 1, an inherited renal disorder characterized by low molecular weight (LMW) proteinuria and hypercalciuria.	Hydrogen	47-49	chloride voltage-gated channel 5	Homo sapiens	61-66
33548910-2	2021	Alteration of substituents (R 1, R2, R3 = H, C2H, C2F) on pyrimidine ring changes properties of electron charge density at this ring and influences indirectly on strength of intramolecular hydrogen bond (IHB) interactions in the mentioned structures.	Hydrogen	189-197	EMG1 N1-specific pseudouridine methyltransferase	Homo sapiens	45-53
12214319-1	2002	Direct ab initio dynamic calculations are performed on the reactions of atomic hydrogen with GeD(n)(CH(3))(4-n) (n = 1-4) over the temperature range 200-2000 K at the PMP4SDTQ/6-311 +G(3df,2p)//MP2/6-31 +G(d) (for n = 2-4) and G2//MP2/6-31 +G(d) (for n = 1) levels.	Hydrogen	79-87	tryptase pseudogene 1	Homo sapiens	194-202
20205869-10	2010	CONCLUSIONS: This study predicts that crucial hydrogen bonding between N-sh2 domain of Shp-1 and Kit activation loop can modulate the negative regulation of c-Kit kinase by Shp-1.	Hydrogen	46-54	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	87-92
20205869-10	2010	CONCLUSIONS: This study predicts that crucial hydrogen bonding between N-sh2 domain of Shp-1 and Kit activation loop can modulate the negative regulation of c-Kit kinase by Shp-1.	Hydrogen	46-54	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	173-178
20000378-0	2010	A short, strong hydrogen bond in the active site of human carbonic anhydrase II.	Hydrogen	16-24	carbonic anhydrase 2	Homo sapiens	58-79
12214319-1	2002	Direct ab initio dynamic calculations are performed on the reactions of atomic hydrogen with GeD(n)(CH(3))(4-n) (n = 1-4) over the temperature range 200-2000 K at the PMP4SDTQ/6-311 +G(3df,2p)//MP2/6-31 +G(d) (for n = 2-4) and G2//MP2/6-31 +G(d) (for n = 1) levels.	Hydrogen	79-87	tryptase pseudogene 1	Homo sapiens	231-239
20000378-1	2010	The crystal structure of human carbonic anhydrase II (HCA II) obtained at 0.9 A resolution reveals that a water molecule, termed deep water, Dw, and bound in a hydrophobic pocket of the active site forms a short, strong hydrogen bond with the zinc-bound solvent molecule, a conclusion based on the observed oxygen-oxygen distance of 2.45 A.	Hydrogen	220-228	carbonic anhydrase 2	Homo sapiens	31-52
12188642-2	2002	A novel beta N-O turn involving a nine-membered-ring intramolecular hydrogen bond between NHi+2 and COi was formed in diamides 1 and 2, which was further stabilized by another six-membered-ring intramolecular hydrogen bond between NHi+2 and NOi+1.	Hydrogen	68-76	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	100-103
19928871-7	2010	The simulations for the denaturation of the polypeptide GB1 in urea solutions showed that the breaking of its native hydrogen bonds follows a step-by-step process and each step is strongly coupled to the formation of water-carbonyl hydrogen bonds, and to a less extent to the urea-carbonyl hydrogen-bond formation.	Hydrogen	117-125	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	56-59
33910001-4	2021	Upon leucine binding to the synthetic site, H251 and R517 in the connective polypeptide and 50FPYPY54 in the catalytic domain change the hydrogen bond network, leading to conformational change in the C-terminal domain, correlating with RagD association.	Hydrogen	137-145	Ras related GTP binding D	Homo sapiens	236-240
33890390-4	2021	Significantly, a 70-fold enhancement of hydrogen evolution rate (HER) is achieved for nanosized PC-PEG5 , and the FNP-processed PS-PEG5 shows a peak HER rate of up to 37.2 mmol h -1 g -1 under full-spectrum sunlight irradiation, which is among the highest results for polymer photocatalysts.	Hydrogen	40-48	neuronatin	Homo sapiens	99-103
33890390-4	2021	Significantly, a 70-fold enhancement of hydrogen evolution rate (HER) is achieved for nanosized PC-PEG5 , and the FNP-processed PS-PEG5 shows a peak HER rate of up to 37.2 mmol h -1 g -1 under full-spectrum sunlight irradiation, which is among the highest results for polymer photocatalysts.	Hydrogen	40-48	neuronatin	Homo sapiens	131-135
19938875-6	2010	Both Asp271 and Lys303 stabilize the hydroxyimine configuration through hydrogen-bonding interactions with the pyridine nitrogen of the PLP and the imino nitrogen of the Schiff base, respectively.	Hydrogen	72-80	proteolipid protein 1	Homo sapiens	136-139
12188642-2	2002	A novel beta N-O turn involving a nine-membered-ring intramolecular hydrogen bond between NHi+2 and COi was formed in diamides 1 and 2, which was further stabilized by another six-membered-ring intramolecular hydrogen bond between NHi+2 and NOi+1.	Hydrogen	209-217	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	100-103
12188668-2	2002	Substrate analogues differing only in the substitution of a fluorine for the axial C-5 hydrogen would possess reduced electron density at these positions and could be useful mechanistic probes of these enzymes.	Hydrogen	87-95	complement C5	Homo sapiens	83-86
19957936-1	2010	Density functional theory (DFT) predicts a detailed mechanism for the reported potential photocatalytic system for solar hydrogen production from water, (P-da-PNN)RuH(CO) (1, P-da = dearomatized at the phosphorus side arm, PNN = (2-(di-tert-butylphosphinomethyl)-6-diethylaminomethyl)pyridine) (Science 2009, 324, 74).	Hydrogen	121-129	pinin, desmosome associated protein	Homo sapiens	159-162
33636666-7	2021	Specifically, HO  attacked AAP mainly through hydrogen atom transfer (HAT) and radical adduct formation (RAF), while Cl2 - play a certain role through single electron transfer (SET).	Hydrogen	46-54	serpin family F member 2	Homo sapiens	27-30
12167006-3	2002	It is shown that the specific hydrogen bond between His(101H) and Man C-4 OH is preserved in the gaseous complex.	Hydrogen	30-38	complement C4A (Rodgers blood group)	Homo sapiens	70-73
33880054-11	2021	Results: Our results showed that hydrogen can inhibit inflammatory factors (ADAMTS5 and MMP13) and apoptosis factors (cleaved caspase-3, cytochrome c, and Bax) in TBHP-induced chondrocytes.	Hydrogen	33-41	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	76-83
33880054-12	2021	Furthermore, hydrogen can suppress the activation of JNK signaling pathway, whereas the effect of hydrogen can be abolished by anisomycin (a JNK activator).	Hydrogen	13-21	mitogen-activated protein kinase 8	Mus musculus	53-56
20023936-1	2010	In solution, unsubstituted guanine (GH2) is in a tautomeric equilibrium between 1H,7H-keto and 1H,9H-keto forms.	Hydrogen	80-82	growth hormone 2	Homo sapiens	36-39
20023936-1	2010	In solution, unsubstituted guanine (GH2) is in a tautomeric equilibrium between 1H,7H-keto and 1H,9H-keto forms.	Hydrogen	95-97	growth hormone 2	Homo sapiens	36-39
33880054-12	2021	Furthermore, hydrogen can suppress the activation of JNK signaling pathway, whereas the effect of hydrogen can be abolished by anisomycin (a JNK activator).	Hydrogen	98-106	mitogen-activated protein kinase 8	Mus musculus	141-144
33880054-13	2021	In vivo results showed that hydrogen can down-regulate the expression of p-JNK and cleaved caspase-3 expression.	Hydrogen	28-36	mitogen-activated protein kinase 8	Mus musculus	75-78
12124262-6	2002	The subsequent simulation on Arg-207-Ala (R207A) mutation of gelsolin indicated that this mutation facilitates the unbinding of the tail helix and that the contribution of the hydrogen bond between Arg-207 and Asp-744 to the binding is more than 50%, which offers a new clue for further mutagenesis study on the activation mechanism of gelsolin.	Hydrogen	176-184	gelsolin	Homo sapiens	61-69
19960064-1	2010	Hyperfine couplings and g-values of nitroxyl spin labels are sensitive to polarity and hydrogen bonding in the environment probed.	Hydrogen	87-95	spindlin 1	Homo sapiens	45-49
19924848-8	2009	For the Trpzip4, the path ensembles indicate that the final F-N step is much more difficult than for GB1 and involves partial unfolding, rezipping of hydrogen bonds, and rearrangement of the Trp-14 side chain.	Hydrogen	150-158	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	101-104
12096913-1	2002	The conformational transitions of a small oncogene product, p13(MTCP1), have been studied by high-pressure fluorescence of the intrinsic tryptophan emission and high-pressure 1D and 2D 1H-15N NMR.	Hydrogen	185-187	H3 histone pseudogene 6	Homo sapiens	60-63
19883101-11	2009	Separately, molecular hydrogen (H(2)) gas is observed to bind 1, but in contrast to other ligands presently studied, H(2) complexation is spectrally manifested by fast exchange throughout virtually the entire range of available conditions, as well as by a complex dependence of the guest (1)H resonance frequency upon temperature and host concentration.	Hydrogen	22-30	3-hydroxyacyl-CoA dehydratase 3	Homo sapiens	57-63
19883101-11	2009	Separately, molecular hydrogen (H(2)) gas is observed to bind 1, but in contrast to other ligands presently studied, H(2) complexation is spectrally manifested by fast exchange throughout virtually the entire range of available conditions, as well as by a complex dependence of the guest (1)H resonance frequency upon temperature and host concentration.	Hydrogen	32-36	3-hydroxyacyl-CoA dehydratase 3	Homo sapiens	57-63
33921209-8	2021	GLP-1 and gastrin decrease the expression of Na+-K+/ATPase and increase the phosphorylation of sodium/hydrogen exchanger type 3 (NHE3) in human renal proximal tubule cells (hRPTCs).	Hydrogen	102-110	solute carrier family 9 member A3	Homo sapiens	129-133
33833136-4	2021	Here, we analyzed the conformational dynamics of SOST-LRP6 E1E2 complex using hydrogen/deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	78-86	sclerostin	Mus musculus	49-53
12074663-0	2002	Hydrogen-bonded charge-transfer complexes of TTF containing a uracil moiety: crystal structures and electronic properties of the hydrogen cyananilate and TCNQ complexes.	Hydrogen	0-8	ras homolog family member H	Homo sapiens	45-48
33833136-4	2021	Here, we analyzed the conformational dynamics of SOST-LRP6 E1E2 complex using hydrogen/deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	78-86	low density lipoprotein receptor-related protein 6	Mus musculus	54-58
19918057-6	2009	Despite the lack of a DFG motif, ATP binding to haspin is similar to that in classical kinases; however, the ATP gamma-phosphate forms hydrogen bonds with the conserved catalytic loop residues Asp-649 and His-651, and a His651Ala haspin mutant is inactive, suggesting a direct role for the catalytic loop in ATP recognition.	Hydrogen	135-143	histone H3 associated protein kinase	Homo sapiens	48-54
19744646-8	2009	The conformational populations were found to be in good agreement with the limited available NMR data except for the C-2-C-3 torsion (spanned by the O-2-O-4 hydrogen bond), where the NMR data support a more bent structure.	Hydrogen	157-165	complement C3	Homo sapiens	121-124
12023936-4	2002	Molecular modelling of the CYP1A2 interaction with hydroxylated derivatives of flavone suggests that a number of hydrophobic residues of the substrate-binding domain engage in hydrogen bonding with such inhibitors.	Hydrogen	176-184	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	27-33
19767119-5	2009	IL-1beta treatment for 1h activated JNK and resulted in both post-translational modification and reduction of nuclear RXRalpha.	Hydrogen	23-25	mitogen-activated protein kinase 8	Mus musculus	36-39
33837215-3	2021	In this study, the first example of a nitrogen-rich hydrogen-bonded organic framework (HOF-NF) is designed and constructed through self-assembly in energetic materials, in which NF anions are trapped in pores of the resulting framework via the dual force of ionic and hydrogen bonds from the strengthened framework.	Hydrogen	52-60	neurofascin	Homo sapiens	91-93
33837215-3	2021	In this study, the first example of a nitrogen-rich hydrogen-bonded organic framework (HOF-NF) is designed and constructed through self-assembly in energetic materials, in which NF anions are trapped in pores of the resulting framework via the dual force of ionic and hydrogen bonds from the strengthened framework.	Hydrogen	52-60	neurofascin	Homo sapiens	178-180
33837215-3	2021	In this study, the first example of a nitrogen-rich hydrogen-bonded organic framework (HOF-NF) is designed and constructed through self-assembly in energetic materials, in which NF anions are trapped in pores of the resulting framework via the dual force of ionic and hydrogen bonds from the strengthened framework.	Hydrogen	268-276	neurofascin	Homo sapiens	91-93
33837215-3	2021	In this study, the first example of a nitrogen-rich hydrogen-bonded organic framework (HOF-NF) is designed and constructed through self-assembly in energetic materials, in which NF anions are trapped in pores of the resulting framework via the dual force of ionic and hydrogen bonds from the strengthened framework.	Hydrogen	268-276	neurofascin	Homo sapiens	178-180
12023936-12	2002	Our results support the molecular model"s prediction of the critical amino acid residues present in the hydrophobic active site, residues that can hydrogen bond with CYP1A2 inhibitors and modify substrate binding and/or turnover.	Hydrogen	147-155	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	166-172
19646993-3	2009	Due to its role in cellular protection against oxidative stress that is believed to originate from its reactive oxygen species scavenging ability in combination with exposed methionine at the surface of proteins, the susceptibility of MsrA to hydrogen-peroxide-mediated oxidative inactivation has been analyzed.	Hydrogen	243-251	methionine sulfoxide reductase A	Homo sapiens	235-239
12123020-1	2002	The iridium complex [Ir(mu-Cl)(PN)(PPh3)]2 (1) reacts with H2 affording only the kinetic isomer OC-6-55-C of the dihydride [IrClH2(PN)(PPh3)] (2) and with methanol yielding, also exclusively, the thermodynamic isomer OC-6-53-C (2b) of the same dihydride; complex 2b has been characterised by X-ray diffractometric methods.	Hydrogen	59-61	protein phosphatase 4 catalytic subunit	Homo sapiens	35-39
19729619-1	2009	Spin-ice materials are magnetic substances in which the spin directions map onto hydrogen positions in water ice.	Hydrogen	81-89	spindlin 1	Homo sapiens	0-4
33388257-4	2021	Moreover, this compound could bind to tyrosinase and form 5-M-2-MB-tyrosinase complex by hydrogen bond and hydrophobic interaction.	Hydrogen	89-97	tyrosinase	Homo sapiens	38-48
33388257-4	2021	Moreover, this compound could bind to tyrosinase and form 5-M-2-MB-tyrosinase complex by hydrogen bond and hydrophobic interaction.	Hydrogen	89-97	tyrosinase	Homo sapiens	67-77
19729619-1	2009	Spin-ice materials are magnetic substances in which the spin directions map onto hydrogen positions in water ice.	Hydrogen	81-89	spindlin 1	Homo sapiens	56-60
12123020-1	2002	The iridium complex [Ir(mu-Cl)(PN)(PPh3)]2 (1) reacts with H2 affording only the kinetic isomer OC-6-55-C of the dihydride [IrClH2(PN)(PPh3)] (2) and with methanol yielding, also exclusively, the thermodynamic isomer OC-6-53-C (2b) of the same dihydride; complex 2b has been characterised by X-ray diffractometric methods.	Hydrogen	59-61	protein phosphatase 4 catalytic subunit	Homo sapiens	135-139
19774253-1	2009	In situ STM imaging of Au(100) electrode in 1 M HClO4 + 0.03 M aniline revealed highly ordered aniline adlattices of (2 radical 2 x 4 radical 2)R45 degrees and (radical 10 x radical 10)R18 degrees and polyaniline molecules exhibiting wiggling conformations at potentials negative and positive of 0.95 V (vs. reversible hydrogen electrode), respectively.	Hydrogen	319-327	sulfotransferase family 1A member 3	Homo sapiens	8-11
33480461-6	2021	The UCST property of the poly(AAc-NVP-AAm) comes from the AAc-AAm and AAc-NVP hydrogen-bonds, while the LCST property of poly(AAc-NVP-DMA) originates from the hydrophobic aggregation of AAc-NVP complex and DMA, as indicated by temperature-dependent 1 H NMR and dynamic light scattering.	Hydrogen	78-86	glycine-N-acyltransferase	Homo sapiens	30-33
11863427-3	2002	MP2 optimizations show that, while neutral quinones and an indole molecule prefer a pi-stacked arrangement, semiquinone radical anions prefer a T-stacked conformation with significant N-H...pi hydrogen bonding interactions.	Hydrogen	193-201	tryptase pseudogene 1	Homo sapiens	0-3
19774279-5	2009	Polyols with their hydroxyl groups distributed along the hydrocarbon backbone in an all-syn configuration are highly rigid and form an extended quasi 1-dimensional hydrogen-bond wire that is stable for tens of picoseconds.	Hydrogen	164-172	synemin	Homo sapiens	88-91
19774279-7	2009	This finding supports a mechanism for vibrational energy relaxation in all-syn polyols that is mediated by hydrogen-bond dissociation within 850 fs.	Hydrogen	107-115	synemin	Homo sapiens	75-78
15348624-14	2002	A splitting of the C17-O peak at 1284 cm(-1) and 1294 cm(-1) was attributed to the existence of at least two types of crystal forms - one that exhibits hydrogen bonding and one that does not.	Hydrogen	152-160	cytokine like 1	Homo sapiens	19-22
19446049-7	2009	Short-term treatment of HUVECs with Ti for 1h effectively enhanced the phosphorylation of eNOS, PKC (pan) and ERK1/2.	Hydrogen	43-45	protein kinase C, alpha	Rattus norvegicus	96-99
33497888-3	2021	This potent GAK binding affinity was rationalized by molecular modelling demonstrating that the carboxamide moiety engages in an extra hydrogen bond with GAK.	Hydrogen	135-143	cyclin G associated kinase	Homo sapiens	12-15
33497888-3	2021	This potent GAK binding affinity was rationalized by molecular modelling demonstrating that the carboxamide moiety engages in an extra hydrogen bond with GAK.	Hydrogen	135-143	cyclin G associated kinase	Homo sapiens	154-157
11851407-1	2002	Amide hydrogen exchange has been used to examine the structural dynamics and energetics of the interaction of a peptide corresponding to the calmodulin-binding domain of smooth muscle myosin light chain kinase (smMLCKp) with calcium-saturated calmodulin.	Hydrogen	6-14	myosin light chain kinase	Homo sapiens	170-209
33577335-6	2021	Further surface plasmon resonance (SPR) and hydrogen/deuterium exchange mass spectroscopic experiments confirm that the evaluated complex type N-glycan impedes the binding between IL-17A and its receptor IL-17RA.	Hydrogen	44-52	interleukin 17A	Homo sapiens	180-186
33624755-7	2021	The results of site-directed mutant assay and molecular docking revealed that E105, N50 and the residues around them on HA2 subunit could form hydrogen bonds with amino acid on ESC-1GN, which were critical for ESC-1GN binding to HA2 and inhibiting the entry of influenza A viruses.	Hydrogen	143-151	myosin IG	Homo sapiens	120-123
11851407-1	2002	Amide hydrogen exchange has been used to examine the structural dynamics and energetics of the interaction of a peptide corresponding to the calmodulin-binding domain of smooth muscle myosin light chain kinase (smMLCKp) with calcium-saturated calmodulin.	Hydrogen	6-14	myosin light chain kinase	Homo sapiens	211-218
33624755-7	2021	The results of site-directed mutant assay and molecular docking revealed that E105, N50 and the residues around them on HA2 subunit could form hydrogen bonds with amino acid on ESC-1GN, which were critical for ESC-1GN binding to HA2 and inhibiting the entry of influenza A viruses.	Hydrogen	143-151	myosin IG	Homo sapiens	229-232
11851407-5	2002	Hydrogen exchange rates and corresponding protection factors (1/K(op)) for individual amide protons of the bound smMLCKp domain span 5 orders of magnitude at ambient pressure.	Hydrogen	0-8	myosin light chain kinase	Homo sapiens	113-120
11668181-2	2002	It forms hydrogen bonds to the O2 and N3 of the flavoprotein prosthetic group, FMN.	Hydrogen	9-17	formin 1	Homo sapiens	79-82
11822460-12	2002	In agreement with the recent X-ray structure of hOGG1 in complex with 8-oxo-7,8-dihydroguanine-containing DNA, we can conclude that repair enzymes can contact both lesions only via the N(7)-H group, which is a hydrogen-bond acceptor in guanine.	Hydrogen	210-218	8-oxoguanine DNA glycosylase	Homo sapiens	48-53
33543617-4	2021	K1, K2, and GA might compete with d-glucose to form hydrogen bonds with the same active residues including GLU-412, GLY-416, GLN-314, and TRP-420 in GLUT2.	Hydrogen	52-60	solute carrier family 2 member 2	Homo sapiens	149-154
11751325-6	2002	Asp27d present in CDR1 formed hydrogen bonds with the side-chain and main-chain atoms within the loop.	Hydrogen	30-38	cerebellar degeneration related protein 1	Homo sapiens	18-22
19638273-0	2009	Structural studies of the N-terminus of Connexin 32 using 1H NMR spectroscopy.	Hydrogen	58-60	gap junction protein beta 1	Homo sapiens	40-51
11754736-0	2002	Effects of hydrogen bonds in association with flavin and substrate in flavoenzyme d-amino acid oxidase.	Hydrogen	11-19	D-amino acid oxidase	Homo sapiens	82-102
33559526-10	2021	The interaction triggered a conformational selection-like effect on DLL1, allowing new hydrogen bonds on the beta3-beta4 interface loop.	Hydrogen	87-95	delta like canonical Notch ligand 1	Homo sapiens	68-72
11754736-2	2002	According to the three-dimensional structure of a porcine kidney D-amino acid oxidase-substrate (D-leucine) complex model, the G313 backbone carbonyl recognizes the substrate amino group by hydrogen bonding and the side-chain hydroxyl of T317 forms a hydrogen bond with C(2)=O of the flavin moiety of FAD [Miura et al.	Hydrogen	190-198	D-amino acid oxidase	Homo sapiens	65-85
19700559-4	2009	At variance with this scheme, we report that a mutant lacking starch (defective for sta6) produces similar hydrogen amounts as the parental strain in conditions of sulfur deprivation.	Hydrogen	107-115	uncharacterized protein	Chlamydomonas reinhardtii	84-88
11754736-2	2002	According to the three-dimensional structure of a porcine kidney D-amino acid oxidase-substrate (D-leucine) complex model, the G313 backbone carbonyl recognizes the substrate amino group by hydrogen bonding and the side-chain hydroxyl of T317 forms a hydrogen bond with C(2)=O of the flavin moiety of FAD [Miura et al.	Hydrogen	251-259	D-amino acid oxidase	Homo sapiens	65-85
11754736-7	2002	The results imply that the hydrogen bond between the G313 backbone carbonyl and the substrate amino group plays important roles in substrate recognition and in defining the substrate specificity of D-amino acid oxidase.	Hydrogen	27-35	D-amino acid oxidase	Homo sapiens	198-218
33068779-4	2021	Hyperthermia (41  C, 1h) of human hepatocellular carcinoma cells (HuH7) led to transient increased production of immunomodulatory factors.	Hydrogen	21-23	MIR7-3 host gene	Homo sapiens	66-70
11885988-0	2002	1H, 13C and "5N resonance assignments of GABARAP, GABAA receptor associated protein.	Hydrogen	0-2	GABA type A receptor-associated protein	Homo sapiens	41-48
33463630-6	2021	Furthermore, hydrogen passivation reduces the bands around the Fermi level and shift them toward the region of negative energies, which can be seen from the presence of NDR in the transport properties of the hydrogenated device.	Hydrogen	13-21	serine/threonine kinase 38	Homo sapiens	169-172
19545622-9	2009	These results demonstrate that CaMKII plays a critical upstream role in mediating the effects of H(2)O(2) on ERK1/2, PKB, and IGF-1R phosphorylation.	Hydrogen	97-101	insulin like growth factor 1 receptor	Homo sapiens	126-132
11885988-0	2002	1H, 13C and "5N resonance assignments of GABARAP, GABAA receptor associated protein.	Hydrogen	0-2	GABA type A receptor-associated protein	Homo sapiens	50-83
19650640-0	2009	Structural dynamics of soluble chloride intracellular channel protein CLIC1 examined by amide hydrogen-deuterium exchange mass spectrometry.	Hydrogen	94-102	chloride intracellular channel 1	Homo sapiens	70-75
19650640-4	2009	Rapid hydrogen exchange data indicate that CLIC1 displays a similar core structure at these pH values.	Hydrogen	6-14	chloride intracellular channel 1	Homo sapiens	43-48
11735541-4	2001	In contrast, cis-1,4-bis(triphenylsilylethynyl)cyclohexane-1,4-diol reacts with Co(2)(CO)(8) to yield the twist-boat conformer in which the two axial hydroxy substituents exhibit intra-molecular hydrogen bonding.	Hydrogen	195-203	suppressor of cytokine signaling 1	Homo sapiens	13-18
11735541-5	2001	Likewise, the corresponding reaction of cis-1,4-bis(trimethylsilylethynyl)cyclohexane-1,4-diol with Co(2)(CO)(8) leads to a twist-boat, but in this case, the molecules are linked through inter-molecular hydrogen bonds.	Hydrogen	203-211	suppressor of cytokine signaling 1	Homo sapiens	40-45
11733024-4	2001	We report here that amino-acid substitutions in a buried cluster of three residues forming a hydrogen bonding network in the shutter region drastically accelerate PAI-1 latency transition; that the rate was in all cases normalized by the PAI-1 binding protein vitronectin; and that substitution of an adjacent beta strand 5A Lys residue, believed to anchor beta strand 5A to other secondary structural elements, had differential effects on the rates of latency transition in the absence and the presence of vitronectin, respectively.	Hydrogen	93-101	serpin family E member 1	Homo sapiens	163-168
19726854-6	2009	An intramolecular O-H...N hydrogen bond stabilizes the syn conformation of the nucleoside.	Hydrogen	26-34	synemin	Homo sapiens	55-58
19629454-4	2009	ILs containing [FAP]- possessed lower hydrogen bond basicity than NTf2-based ILs having the same cationic component; in the case of hydroxyl-functionalized cations, the presence of [FAP]- led to an enhancement of the hydrogen bond acidity, relative to the NTf2-analogs.	Hydrogen	217-225	nuclear transport factor 2	Homo sapiens	66-70
33482814-0	2021	Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis.	Hydrogen	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	113-117
11733024-4	2001	We report here that amino-acid substitutions in a buried cluster of three residues forming a hydrogen bonding network in the shutter region drastically accelerate PAI-1 latency transition; that the rate was in all cases normalized by the PAI-1 binding protein vitronectin; and that substitution of an adjacent beta strand 5A Lys residue, believed to anchor beta strand 5A to other secondary structural elements, had differential effects on the rates of latency transition in the absence and the presence of vitronectin, respectively.	Hydrogen	93-101	serpin family E member 1	Homo sapiens	238-243
19629454-4	2009	ILs containing [FAP]- possessed lower hydrogen bond basicity than NTf2-based ILs having the same cationic component; in the case of hydroxyl-functionalized cations, the presence of [FAP]- led to an enhancement of the hydrogen bond acidity, relative to the NTf2-analogs.	Hydrogen	217-225	nuclear transport factor 2	Homo sapiens	256-260
11763166-5	2001	Other studies in which the 4-oxo group of the pyrimidine ring portion of pemetrexed was replaced with a hydrogen atom, demonstrated that the resulting analogs were potent DHFR inhibitors with very little activity against the enzymes glycinamide ribonucleotide formyltransferase (GARFT) and TS [310674].	Hydrogen	104-112	dihydrofolate reductase	Homo sapiens	171-175
19660780-3	2009	Different to the previous deductions, hydrogen donating efficiency and electron donating efficiency of solvents were not the decisive factors for the photolytic rate in this study, which was proved by the fast photolysis of BDE-209 in CCl(4), a solvent without hydrogen and difficult to donate electrons.	Hydrogen	261-269	homeobox D13	Homo sapiens	224-227
19483477-2	2009	In vitro, HS inhibited the growth of B16F10 cells and proliferation of VEGF-induced HUVEC dose-dependently compared to the control, VEGF-induced capillary-like tube networks and the numbers of migratory and invasive cells were significantly inhibited by HS in a dose-dependent manner under the cytotoxic doses.	Hydrogen	10-12	vascular endothelial growth factor A	Mus musculus	71-75
11860291-5	2001	Pseudouridine formation creates a hydrogen bond donor at the equivalent of uridine C-5.	Hydrogen	34-42	complement C5	Homo sapiens	83-86
19483477-2	2009	In vitro, HS inhibited the growth of B16F10 cells and proliferation of VEGF-induced HUVEC dose-dependently compared to the control, VEGF-induced capillary-like tube networks and the numbers of migratory and invasive cells were significantly inhibited by HS in a dose-dependent manner under the cytotoxic doses.	Hydrogen	10-12	vascular endothelial growth factor A	Mus musculus	132-136
19843007-8	2009	A striking increase in GCM1 was observed when villous explants were incubated for 1h in 1% O2 (p &lt; 0.002).	Hydrogen	82-84	glial cells missing transcription factor 1	Homo sapiens	23-27
33441904-8	2021	Furthermore, the interaction between 4b and the ADAMTS-5 Dis domain is mediated by hydrogen bonds between the sugar moiety and two lysine residues (K532 and K533).	Hydrogen	83-91	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	48-56
11477109-4	2001	For EPA, the presence of an additional double bond (C-17/C-18) causes this substrate to bind in a "strained" conformation in which C-13 is misaligned with respect to Tyr-385, the residue that abstracts hydrogen from substrate fatty acids.	Hydrogen	202-210	cytokine like 1	Homo sapiens	52-61
33039662-3	2021	In the present study, we hypothesized that the phagocyte-specific proton channel Hv1 mediates hydrogen proton extrusion after SCI, contributing to increased extracellular acidosis and poor long-term outcomes.	Hydrogen	94-102	hepatitis virus (MHV-2) susceptibility	Mus musculus	81-84
33369156-6	2021	RESULTS: Through bivariate correlation analysis, we found that serum GDF15 is linearly correlated with glucose metabolism indices, such as 1h-PG, 2h-PG, HbA1c (all p<0.05).	Hydrogen	139-141	growth differentiation factor 15	Homo sapiens	69-74
19467564-11	2009	The cathodic production of H2 by anaerobic corrosion of Fe probably sustained a higher level of SRB activity in the FeOC column.	Hydrogen	27-29	chaperonin containing TCP1 subunit 4	Homo sapiens	96-99
11477109-9	2001	Val-349 contacts C-2 and C-3 of EPA and C-4 of LA orienting the carboxyl halves of these substrates so that the omega-ends are aligned properly for hydrogen abstraction.	Hydrogen	148-156	complement C2	Homo sapiens	17-20
11477109-9	2001	Val-349 contacts C-2 and C-3 of EPA and C-4 of LA orienting the carboxyl halves of these substrates so that the omega-ends are aligned properly for hydrogen abstraction.	Hydrogen	148-156	complement C4A (Rodgers blood group)	Homo sapiens	40-43
19842489-3	2009	Therefore, the carbon atom within both these systems, being in its atomic state, can have one or two lone electron pairs and, as a result, it may form hydrogen bonds of the type D-H...CL2, where C acts as a proton acceptor.	Hydrogen	151-159	endogenous retrovirus group W member 5	Homo sapiens	184-187
33291125-2	2020	In this work, we have prepared new Al-doped Ni3S2 nanosheet arrays grown on Ni foam (Al-Ni3S2/NF) as an excellent bifunctional electrocatalyst in the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER).	Hydrogen	150-158	neurofascin	Homo sapiens	94-96
11574727-5	2001	The dimer in (1) and the trimer in (3) are built up via [O-H...N=C] hydrogen bonds, while the polymer of (2) is via the [OH...NMe2] hydrogen bond.	Hydrogen	132-140	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	126-130
19916465-5	2009	After that, the Nd2(Fe, Co)14BH(x) phase is gradually disproportionated into alpha-Fe(Co), NdH2.7, and (Fe, Co)2B phases upon further milling in hydrogen.	Hydrogen	145-153	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	16-19
19638477-3	2009	Based on a published high-resolution (2.89 A) tubulin structure, we predict that Arg-2 of alpha-tubulin forms hydrogen bonds with the GTPase domain of beta-tubulin, and structural modeling suggests that these contacts are interrupted in tor2.	Hydrogen	110-118	tubulin alpha-5	Arabidopsis thaliana	90-103
11605660-3	2001	A novel series of quinoline azodyes (5-(4"-derivatives phenyldiazo)-8-hydroxy-7-quinolinecarboxaldehyde)) (HL1-HL5) has been prepared and characterized by elemental analyses, 1H-NMR and IR spectra.	Hydrogen	175-177	intelectin 1	Homo sapiens	107-114
19419194-2	2009	Published X-ray crystal structures of yeast guanylate kinase indicate that K14 is part of the "P" loop involved in ATP and ADP binding, while R41 is suggested as a hydrogen bonding partner for the phosphoryl moiety of GMP.	Hydrogen	164-172	guanylate kinase	Saccharomyces cerevisiae S288C	44-60
33390902-9	2020	1H-MRS quantified GABA concentrations in both frontal cortex and thalamus of wild type and Fmr1 knockout mice.	Hydrogen	0-2	fragile X messenger ribonucleoprotein 1	Mus musculus	91-95
33390902-11	2020	We found significant changes in GABA concentration between the frontal cortex and thalamus within each mouse from both wild type and Fmr1 knockout mice using 1H-MRS and LC-MS/MS.	Hydrogen	158-160	fragile X messenger ribonucleoprotein 1	Mus musculus	133-137
11727986-0	2001	Backbone 1H, 13C, and 15N resonance assignments for a 14 kD protein, GABA(A) receptor associated protein (GABARAP).	Hydrogen	9-11	GABA type A receptor-associated protein	Homo sapiens	69-104
33256396-4	2020	To explain the formation of [an + 2H]+ and [xm + 2H]+, hydrogen attachment to the carbonyl carbon atom on the peptide backbone is proposed to initiate Calpha-C bond cleavage.	Hydrogen	55-63	carbonic anhydrase 2	Homo sapiens	151-159
19462040-4	2009	DFT calculations indicate that boat-shaped transition structures that allow the formation of a stabilizing hydrogen bond can account for the unusual anti,syn-stereoselectivity of the aldol addition to beta-protected 2,4-O-ethylidene-erythroses.	Hydrogen	107-115	synemin	Homo sapiens	154-157
11727986-0	2001	Backbone 1H, 13C, and 15N resonance assignments for a 14 kD protein, GABA(A) receptor associated protein (GABARAP).	Hydrogen	9-11	GABA type A receptor-associated protein	Homo sapiens	106-113
11591345-6	2001	The interface of the E2-Ub intermediate was determined by kinetically monitoring thiolester formation by 1H-(15)N HSQC spectra by using combinations of 15N-labeled and unlabeled Ubc1(Delta450) and Ub proteins.	Hydrogen	105-107	E2 ubiquitin-conjugating protein UBC1	Saccharomyces cerevisiae S288C	111-112
19390419-8	2009	Structural modeling suggested the formation of an additional hydrogen bond between V3 and CCR5.	Hydrogen	61-69	C-C motif chemokine receptor 5	Homo sapiens	90-94
32829156-5	2020	Hydrogen bonding and van der Waals forces played a major role in the interactions of XY with beta-LG and beta-CN, and both interactions were exothermic.	Hydrogen	0-8	beta-lactoglobulin	Bos taurus	93-100
32829157-10	2020	Our findings suggest that the eIF4F IRE RNA complex formation is accompanied by an elevated hydrogen bonding and weakened hydrophobic interactions, leading to an overall conformational change, favored in terms of its free energy.	Hydrogen	92-100	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	30-35
19414254-2	2009	The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds.	Hydrogen	84-92	casein kinase 2 alpha 2	Homo sapiens	23-31
11498242-5	2001	Induction of IL-1 beta expression occurred within 1h post-stimulation with trout rIL-1 beta and was maximal 3-6h post-stimulation.	Hydrogen	50-52	interleukin-1 beta	Oncorhynchus mykiss	13-22
19636948-0	2009	1H, 15N, 13C resonance assignments of the reduced and active form of human Protein Tyrosine Phosphatase, PRL-1.	Hydrogen	0-2	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	75-103
19417935-7	2009	Complex 3 can crystallize as the enantiomorph 3S in the tetragonal, chiral space group P41 in a spontaneous resolution of the racemic mixture into homo-chiral helix-enantiomers due to inter-molecular N-H...O hydrogen bonding which connects only molecules of the same (S-) configuration into (right-handed or P-) 41-helical chains.	Hydrogen	208-216	erythrocyte membrane protein band 4.1	Homo sapiens	87-90
33344518-2	2020	We previously demonstrated that sodium/glucose cotransporter 2 inhibitors (SGLT2i"s) have direct cardiac effects on ion homeostasis, possibly through inhibition of the cardiac sodium/hydrogen exchanger (NHE-1).	Hydrogen	183-191	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	75-80
11583162-0	2001	A two-process model describes the hydrogen exchange behavior of cytochrome c in the molten globule state with various extents of acetylation.	Hydrogen	34-42	cytochrome c, somatic	Equus caballus	64-76
33276663-2	2020	In CA1, as a monohydrate, the hydrogen bonds were pronounced around the water of crystallization (O4), and the planar cyclic sites were arranged in parallel to slightly tilted positions.	Hydrogen	30-38	carbonic anhydrase 1	Homo sapiens	3-6
19259722-13	2009	Given the critical role of proton pumping in bone resorption, the Slc9a3r2 gene, a sodium/hydrogen exchanger, was also considered as a candidate for the op mutation.	Hydrogen	90-98	SLC9A3 regulator 2	Rattus norvegicus	66-74
11587644-7	2001	A comparison of the novel PPARalpha/AZ 242 complex with the PPARgamma/AZ 242 complex and previously solved PPARgamma structures reveals a conserved hydrogen bonding network between agonists and the AF2 helix.	Hydrogen	148-156	peroxisome proliferator activated receptor alpha	Homo sapiens	26-35
19324554-5	2009	This is in correspondence with literature reports which suggest that hydrogen bond formation is involved in stabilizing inhibitor-MAO-B complexes.	Hydrogen	69-77	monoamine oxidase B	Homo sapiens	130-135
32941989-4	2020	In addition, a docking study revealed that 17b could form key hydrogen bonds with Ala173, Glu171 and Glu177 in Aurora B.	Hydrogen	62-70	aurora kinase B	Homo sapiens	111-119
11454337-4	2001	13C NMR studies using D-(1-(13)C)glucose and D-(1-(13)C)galactose with the CaCl(2) system in CD(3)OD revealed that the C-2 epimerization proceeds via stereospecific rearrangement of the carbon skeleton, or 1,2-carbon shift, and ketose formation proceeds partially through an intramolecular hydrogen migration or 1,2-hydride shift and, in part, via an enediol intermediate.	Hydrogen	290-298	complement C2	Homo sapiens	119-122
32814064-10	2020	Multiplex cytokine assay demonstrated the most profound regulatory effects induced by HI on the levels of IL-12, IFN-gamma, and GM-CSF at 24 h post-TBI, which confirmed the inhibitory effect of hydrogen on microglia activation.	Hydrogen	194-202	colony stimulating factor 2	Rattus norvegicus	128-134
19309090-0	2009	DFT and ONIOM(DFT:MM) studies on Co-C bond cleavage and hydrogen transfer in B12-dependent methylmalonyl-CoA mutase.	Hydrogen	56-64	methylmalonyl-CoA mutase	Homo sapiens	91-115
19309090-2	2009	The considerable protein effect on the homolytic Co-C bond cleavage to form the 5"-deoxyadenosyl (Ado) radical and cob(II)alamin and the subsequent hydrogen transfer from the methylmalonyl-CoA substrate to the Ado radical in the methylmalonyl-CoA mutase (MMCM) have been extensively studied by DFT and ONIOM(DFT/MM) methods.	Hydrogen	148-156	methylmalonyl-CoA mutase	Homo sapiens	229-253
19309090-2	2009	The considerable protein effect on the homolytic Co-C bond cleavage to form the 5"-deoxyadenosyl (Ado) radical and cob(II)alamin and the subsequent hydrogen transfer from the methylmalonyl-CoA substrate to the Ado radical in the methylmalonyl-CoA mutase (MMCM) have been extensively studied by DFT and ONIOM(DFT/MM) methods.	Hydrogen	148-156	methylmalonyl-CoA mutase	Homo sapiens	255-259
19231824-0	2009	Dynamical binding of hydrogen-bond surrogate derived Bak helices to antiapoptotic protein Bcl-xL.	Hydrogen	21-29	BCL2 antagonist/killer 1	Homo sapiens	53-56
19129176-4	2009	Although the structure has the overall architecture of a paired EF-hand domain, the NaV1.2 C-terminal domain does not bind Ca2+ through the canonical EF-hand loops, as evidenced by monitoring 1H,15N chemical shifts during aCa2+ titration.	Hydrogen	192-194	sodium voltage-gated channel alpha subunit 2	Homo sapiens	84-90
33025647-4	2020	Molecular docking studies indicated that OA bound to alpha-La/beta-Lg by hydrogen bonds and hydrophobic interaction.	Hydrogen	73-81	beta-lactoglobulin	Bos taurus	62-69
11428921-0	2001	Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK(1) receptor antagonist.	Hydrogen	33-41	tachykinin receptor 1	Homo sapiens	85-99
19057931-6	2009	From the docking studies, we also suggest that Asp176 and Ser218 only form hydrogen bonds with sialic acid, therefore, they may help sialic acid interact with hNAL steadly.	Hydrogen	75-83	N-acetylneuraminate pyruvate lyase	Homo sapiens	159-163
11519752-0	2001	1H and 15N sequential assignment and secondary structure of the monomeric N67D mutant of bovine seminal ribonuclease.	Hydrogen	0-2	seminal ribonuclease	Bos taurus	96-116
19122177-4	2009	Here we show that the alpha(1H) voltage-gated T-type Ca(2+) channel (Ca(v)3.2) is involved in the pathogenesis of cardiac hypertrophy via the activation of calcineurin/nuclear factor of activated T cells (NFAT) pathway.	Hydrogen	28-30	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	69-77
32906104-4	2020	Based on the all-atom molecular dynamics (MD) simulations, we found that O-GlcNAc modifications can suppress the process of oligomerization of alpha-Syn aggregates via a steric effect - the additional O-linked glycosyl group disrupts the formation of hydrogen bonds (H-bonds) between alpha-Syn monomers.	Hydrogen	251-259	synemin	Homo sapiens	149-152
11438962-3	2001	(1)H-NMR studies of a mixture of model compound of CSP 1 and NBD-Ala suggest that the diastereomeric complex is composed of two hydrogen bonding sites at the amino proton and oxygen atom, and a pi-pi interaction by the benzofurazan structure (2,1,3-benzoxadiazole) of NBD-amino acid.	Hydrogen	128-136	regulator of calcineurin 1	Homo sapiens	51-56
33179489-7	2020	The use of a simple, commercially available ligand, PAd3, is key to this water-assisted mechanism by promoting coordinative unsaturation in catalytic intermediates responsible for the heterolytic activation of strong element-hydrogen bonds, which enables broad compatibility of carbon-heteroatom cross-coupling reactions with sensitive substrates and functionality.	Hydrogen	225-233	peptidyl arginine deiminase 3	Homo sapiens	52-56
19119014-7	2009	Chlorthalidone bound within the CA II active site is in an enolic (lactimic) tautomeric form, with the enolic OH also participating in two strong hydrogen bonds with Asn67 and a water molecule.	Hydrogen	146-154	carbonic anhydrase 2	Homo sapiens	32-37
18930806-5	2009	Compared to PRE, the proportion of CD14+/CD16+ monocytes was 27% greater POST and 49% less at 1H and was associated with changes in the CD16(++bright) pro-inflammatory subtype (p&lt;0.05).	Hydrogen	94-96	Fc gamma receptor IIIa	Homo sapiens	41-45
19207420-0	2009	Identification of allosteric PIF-pocket ligands for PDK1 using NMR-based fragment screening and 1H-15N TROSY experiments.	Hydrogen	96-98	pyruvate dehydrogenase kinase 1	Homo sapiens	52-56
19207420-7	2009	Ligand-induced changes in 1H-15N TROSY spectra acquired using uniformly 15N-enriched PDK1 provided evidence to distinguish ATP-site from PDK1 Interacting Fragment-site binding.	Hydrogen	26-28	pyruvate dehydrogenase kinase 1	Homo sapiens	85-89
19207420-7	2009	Ligand-induced changes in 1H-15N TROSY spectra acquired using uniformly 15N-enriched PDK1 provided evidence to distinguish ATP-site from PDK1 Interacting Fragment-site binding.	Hydrogen	26-28	pyruvate dehydrogenase kinase 1	Homo sapiens	137-141
32957071-10	2020	290-310 nm which is not related with light scattering effects in the UV absorption spectra but is related with the formation of mostly intermolecular hydrogen-bonded complexes between Syn tyrosyl groups and aspartic and glutamic acids residues.	Hydrogen	150-158	synemin	Homo sapiens	184-187
11461046-0	2001	Conformation of the tripeptide Cbz-Pro-Leu-Trp-OBzl(CF3)2 deduced from two-dimensional 1H-NMR and conformational energy calculations is related to its affinity for NK1-receptor.	Hydrogen	87-89	tachykinin receptor 1	Homo sapiens	164-176
33138410-1	2020	The reaction of hydrogen atoms (H) with pyrrole (C4H4NH) in solid para-hydrogen (p-H2) matrices at 3.2 K has been studied by infrared spectroscopy.	Hydrogen	16-24	polyhomeotic homolog 2	Homo sapiens	81-85
19063863-3	2009	Fully differentiated 3T3-L1 adipocytes were treated with 10 microM FCCP for 1h, resulting in increased serine-307 phosphorylation of IRS-1 and decreased insulin-stimulated tyrosine phosphorylation, association of p85alpha subunit of phosphatidylinositol 3-kinase (PI 3-kinase) with IRS-1, decreased insulin-stimulated PI 3-kinase activity and H(3)-2-deoxyglucose (2DOG) uptake.	Hydrogen	76-78	insulin	Canis lupus familiaris	153-160
19063863-3	2009	Fully differentiated 3T3-L1 adipocytes were treated with 10 microM FCCP for 1h, resulting in increased serine-307 phosphorylation of IRS-1 and decreased insulin-stimulated tyrosine phosphorylation, association of p85alpha subunit of phosphatidylinositol 3-kinase (PI 3-kinase) with IRS-1, decreased insulin-stimulated PI 3-kinase activity and H(3)-2-deoxyglucose (2DOG) uptake.	Hydrogen	76-78	insulin	Canis lupus familiaris	299-306
11341833-2	2001	We have previously shown by proton NMR that horse serum butyryl cholinesterase, like serine proteases, forms a short, strong hydrogen bond (SSHB) between the Glu-His pair upon binding mechanism-based inhibitors, which form tetrahedral adducts, analogous to the tetrahedral intermediates in catalysis [Viragh, C., et al.	Hydrogen	125-133	butyrylcholinesterase	Homo sapiens	56-78
19113829-5	2009	During the hydrogen bond formation, a transition state can be identified with only one native hydrogen bond being formed, which is more consistent with a "zip-out" mechanism.	Hydrogen	11-19	death associated protein kinase 3	Homo sapiens	155-158
19113829-5	2009	During the hydrogen bond formation, a transition state can be identified with only one native hydrogen bond being formed, which is more consistent with a "zip-out" mechanism.	Hydrogen	94-102	death associated protein kinase 3	Homo sapiens	155-158
33336127-6	2020	Results: Substitution of residue 313 from threonine to isoleucine (Kv7.3[T313I]) likely disrupts a critical intersubunit hydrogen bond.	Hydrogen	121-129	potassium voltage-gated channel subfamily Q member 3 L homeolog	Xenopus laevis	67-72
11353485-0	2001	Metallacoronates or One-Dimensional Polymers through Self-Assembly-Influence of Templates and Hydrogen Bonding on Product Formation Chelate Complexes, Part 17.	Hydrogen	94-102	poly(ADP-ribose) polymerase family member 6	Homo sapiens	151-158
33047664-9	2022	The results indicated that GLN8, LYS9, VAL10, TRP11, GLU48, ASN49 in SCF complex are important determinant residues in binding as they have strong hydrogen bonding with salicylic acid, which showed best docking results with SKP1-CUL1-F-box complex subunit Skp1 with docking score 25.25KJ/mol.	Hydrogen	147-155	SCF ubiquitin ligase subunit SKP1	Saccharomyces cerevisiae S288C	224-228
33047664-9	2022	The results indicated that GLN8, LYS9, VAL10, TRP11, GLU48, ASN49 in SCF complex are important determinant residues in binding as they have strong hydrogen bonding with salicylic acid, which showed best docking results with SKP1-CUL1-F-box complex subunit Skp1 with docking score 25.25KJ/mol.	Hydrogen	147-155	SCF ubiquitin ligase subunit SKP1	Saccharomyces cerevisiae S288C	256-260
18829378-1	2009	The vibrational characteristics (vibrational frequencies and infrared intensities) for the hydrogen-bonded systems of nicotinamide (NA(Z) and NA(E)) with dimethyl sulfoxide (DMSO) have been predicted using ab initio SCF/6-31G(d,p) and DFT (BLYP/6-311++G(d,p)) calculations.	Hydrogen	91-99	KIT ligand	Homo sapiens	216-219
19074271-7	2008	Furthermore, the amount of hydrogen produced by Nda2-RNAi cells under sulfur deprivation is substantially decreased compared with wild type, which supports previous assumptions that endogenous substrates serve as source of electrons for hydrogen formation.	Hydrogen	27-35	uncharacterized protein	Chlamydomonas reinhardtii	48-52
19074271-7	2008	Furthermore, the amount of hydrogen produced by Nda2-RNAi cells under sulfur deprivation is substantially decreased compared with wild type, which supports previous assumptions that endogenous substrates serve as source of electrons for hydrogen formation.	Hydrogen	237-245	uncharacterized protein	Chlamydomonas reinhardtii	48-52
11370788-0	2001	Backbone 1H, 15N, and 13C resonance assignments of ARPP-19.	Hydrogen	9-11	cAMP regulated phosphoprotein 19	Homo sapiens	51-58
19007228-4	2008	2006, 281, 8981), a possible mechanism for the catalytic cycle of tyrosinase is proposed by using quantum mechanical/molecular mechanical calculations, which can reasonably take effects of surrounding amino-acid residues, hydrogen bonding, and protein environment into account.	Hydrogen	222-230	tyrosinase	Homo sapiens	66-76
19043415-3	2008	The crystal structure of MBNL1 ZnF3/4 bound to r(CGCUGU) establishes that both ZnF3 and ZnF4 target GC steps, with site-specific recognition mediated by a network of hydrogen bonds formed primarily with main chain groups of the protein.	Hydrogen	166-174	ZNF4	Homo sapiens	88-92
33047664-11	2022	Salicylic acid hinders the SKP1-CUL1-F-box complex, which is important in protein-like interactions through hydrogen bodings.	Hydrogen	108-116	SCF ubiquitin ligase subunit SKP1	Saccharomyces cerevisiae S288C	27-31
11257229-3	2001	The hydrogen bonding network formed among CBFalpha(Runt domain) and CBFbeta, and CBFalpha(Runt domain) and DNA revealed the allosteric regulation mechanism of CBFalpha(Runt domain)-DNA binding by CBFbeta.	Hydrogen	4-12	core-binding factor subunit beta	Homo sapiens	68-75
32897695-5	2020	The higher potency of both at KOR over MOR may be due to hydrogen-bond formation between non-conserved Y7.35 of KOR and their carbonyl groups.	Hydrogen	57-65	opioid receptor, kappa 1	Mus musculus	30-33
32897695-5	2020	The higher potency of both at KOR over MOR may be due to hydrogen-bond formation between non-conserved Y7.35 of KOR and their carbonyl groups.	Hydrogen	57-65	opioid receptor, kappa 1	Mus musculus	112-115
18343189-5	2008	beta-Substituents in fluorinated enones such as R(2)=H, C(6)H(5), and C(CH(3))(3) assist in the intermolecular hydrogen bond formation of the carbonyl moiety with HBD solvents, while beta-substituents such as CH(3) and 4-NO(2)C(6)H(4) prevent the CO group to form the H-bonds with HBD solvents (the solvent HBD acidity term (alpha) is not significant).	Hydrogen	111-119	HBD	Homo sapiens	163-166
18343189-5	2008	beta-Substituents in fluorinated enones such as R(2)=H, C(6)H(5), and C(CH(3))(3) assist in the intermolecular hydrogen bond formation of the carbonyl moiety with HBD solvents, while beta-substituents such as CH(3) and 4-NO(2)C(6)H(4) prevent the CO group to form the H-bonds with HBD solvents (the solvent HBD acidity term (alpha) is not significant).	Hydrogen	111-119	HBD	Homo sapiens	281-284
11257229-3	2001	The hydrogen bonding network formed among CBFalpha(Runt domain) and CBFbeta, and CBFalpha(Runt domain) and DNA revealed the allosteric regulation mechanism of CBFalpha(Runt domain)-DNA binding by CBFbeta.	Hydrogen	4-12	core-binding factor subunit beta	Homo sapiens	196-203
11430089-4	2001	The trimer and the tetramer are obtained in good yield, and their 1H NMR spectra suggest that these molecules fold in ordered structures, where the C-4 hydrogen of a ring is always close to the carbonyl of the next ring.	Hydrogen	66-68	complement C4A (Rodgers blood group)	Homo sapiens	148-151
18795778-4	2008	Significantly, the intramolecular hydrogen bonding in the biradicals of 8 and 9 was found to reverse their partitioning between cyclization and elimination compared with the behavior of the biradicals of ketones 3; the ketones 8-anti and 9-anti underwent cyclization in benzene, predominantly leading to cyclobutanols with syn stereochemistry between the C2 and C3 substituents.	Hydrogen	34-42	synemin	Homo sapiens	323-326
32747444-6	2020	Peptide binding is mediated by an extended hydrogen-bond network in NS3-4A that was effectively optimized for protease-MAVS binding in Asp168 variants with rescued replicative fitness from NS3-Q41R.	Hydrogen	43-51	KRAS proto-oncogene, GTPase	Homo sapiens	68-71
18795778-7	2008	In particular, the diastereodifferentiation in the photochemical outcomes for the diastereomers of ketone 8 and in the lifetimes of their triplet biradicals can be understood on the basis of rapid deactivation of the 8-syn triplet biradical via fragmentation and slow cyclization of the 8-anti triplet biradical from chair- and twist-boat-like hydrogen-bonded conformations, respectively.	Hydrogen	344-352	synemin	Homo sapiens	219-222
11430089-4	2001	The trimer and the tetramer are obtained in good yield, and their 1H NMR spectra suggest that these molecules fold in ordered structures, where the C-4 hydrogen of a ring is always close to the carbonyl of the next ring.	Hydrogen	152-160	complement C4A (Rodgers blood group)	Homo sapiens	148-151
11306077-5	2001	Like hAR the yeast enzyme is specific for transferring the 4-pro-R hydrogen of the coenzyme.	Hydrogen	67-75	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	5-8
18571493-3	2008	The cold inactivation was prevented by a mutation of Thr177 with the corresponding residue, Asn, in cold-stable pig DHRS4, where this residue is hydrogen-bonded to Asn165 in a substrate-binding loop of other subunit.	Hydrogen	145-153	dehydrogenase/reductase SDR family member 4	Sus scrofa	116-121
33071073-9	2020	Most gases have elicited neurohistological protection in preclinical studies; however, only hydrogen and hydrogen sulfide appeared to preserve CA1 sector of hippocampus, the most vulnerable area in the brain for hypoxia.	Hydrogen	92-100	carbonic anhydrase 1	Homo sapiens	143-146
11163340-2	2001	In general, if the modified ceramide had either a hydrogen bond donor or acceptor at C-1 and C-3, including hydrophobic or hydrophilic groups attached to C-1 microstructures formed.	Hydrogen	50-58	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	85-96
32500230-0	2020	1H, 15N and 13C resonance assignments of the HR1c domain of PRK1, a protein kinase C-related kinase.	Hydrogen	0-2	protein kinase N1	Homo sapiens	60-64
32236803-0	2020	1H, 13C, 15N chemical shift assignments of SHP2 SH2 domains in complex with PD-1 immune-tyrosine motifs.	Hydrogen	0-2	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	43-47
18700760-9	2008	Chemical shift dispersion due to the various 13C-NeuAc adducts on ST6Gal-I was observed in a 3D experiment correlating 1H-13C3-13C2 atoms of the sugar ring.	Hydrogen	119-121	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	66-74
18504625-5	2008	A detailed binding mode analysis of the known inhibitors shows that they can be stabilized in the active site of Cdc25A through the simultaneous establishment of the multiple hydrogen bonds and the hydrophobic interactions.	Hydrogen	175-183	cell division cycle 25A	Homo sapiens	113-119
32240523-0	2020	1H, 13C, and 15N Backbone assignments of the human brain and acute leukemia cytoplasmic (BAALC) protein.	Hydrogen	0-2	BAALC binder of MAP3K1 and KLF4	Homo sapiens	51-103
12836345-4	2001	SPG forms triple stranded complex with single stranded RNAs thorough hydrogen bonding and hydrophobic interaction.	Hydrogen	69-77	SPG16	Homo sapiens	0-3
18636091-4	2008	Within their ligand binding pockets, NR3A and NR3B have strikingly different hydrogen bonding networks and solvent structures from those found in NR1, and fail to undergo a conformational rearrangement observed in NR1 upon binding the partial agonist ACPC.	Hydrogen	77-85	glutamate ionotropic receptor NMDA type subunit 3B	Homo sapiens	46-50
18386080-3	2008	The protein shows unprecedented properties within the cytochrome c (4) family, including (1) an almost nonpolar surface charge distribution, (2) the absence of high-spin heme Fe(III) states, indicative of a thermodynamically stable and kinetically inert axial heme His,Met coordination, and (3) identical E degrees " values for the two heme centers (+0.322 V vs the standard hydrogen elecrode).	Hydrogen	375-383	PSHA_RS13535	Pseudoalteromonas haloplanktis TAC125	54-66
11113602-6	2000	Pretreatment with the COX2 inhibitor NS-398 (9 mg/kg, 1h prior to kainate) inhibited the kainate-stimulated increase of 5LOX and COX2 mRNA levels.	Hydrogen	54-56	arachidonate 5-lipoxygenase	Rattus norvegicus	120-124
18456336-0	2008	Dynamic structural changes during complement C3 activation analyzed by hydrogen/deuterium exchange mass spectrometry.	Hydrogen	71-79	complement C3	Homo sapiens	34-47
32240523-5	2020	In addition, we present a 1HN and 15NH chemical shift comparison of BAALC with its shortest, neuroectodermal isoform (isoform 6) which shows only minor changes in the 1H and 15N chemical shifts.	Hydrogen	26-28	BAALC binder of MAP3K1 and KLF4	Homo sapiens	68-73
11095669-0	2000	Deletion of a single hydrogen bonding atom from the MS2 RNA operator leads to dramatic rearrangements at the RNA-coat protein interface.	Hydrogen	21-29	MS2	Homo sapiens	52-55
32438224-5	2020	Moreover, hesperidin could interact with PL by hydrogen bonds and van der Waals forces, and the interaction would not obviously change the secondary structure of PL.	Hydrogen	47-55	pancreatic lipase	Homo sapiens	41-43
18297741-0	2008	Spin-spin coupling across intramolecular N-H(+)-N hydrogen bonds in models for proton sponges: an ab initio investigation.	Hydrogen	50-58	spindlin 1	Homo sapiens	0-4
18297741-0	2008	Spin-spin coupling across intramolecular N-H(+)-N hydrogen bonds in models for proton sponges: an ab initio investigation.	Hydrogen	50-58	spindlin 1	Homo sapiens	5-9
11023790-10	2000	With bovine lactoferrin, most of the interdomain hydrogen bonds involved in the C-site and one of those involved in the N-site occur between amino acid side-chain residues that cannot protonate.	Hydrogen	49-57	lactotransferrin	Bos taurus	12-23
18222015-6	2008	Ammonia treatment (1h, 5mM NH4Cl) evoked a substantial decrease of CNP-stimulated cGMP synthesis which was related to a decreased binding of CNP to NPR2 receptors, and depressed the CNP-dependent [Ca2+]i accumulation in these cells.	Hydrogen	19-21	natriuretic peptide C	Rattus norvegicus	67-70
18222015-6	2008	Ammonia treatment (1h, 5mM NH4Cl) evoked a substantial decrease of CNP-stimulated cGMP synthesis which was related to a decreased binding of CNP to NPR2 receptors, and depressed the CNP-dependent [Ca2+]i accumulation in these cells.	Hydrogen	19-21	natriuretic peptide C	Rattus norvegicus	141-144
18222015-6	2008	Ammonia treatment (1h, 5mM NH4Cl) evoked a substantial decrease of CNP-stimulated cGMP synthesis which was related to a decreased binding of CNP to NPR2 receptors, and depressed the CNP-dependent [Ca2+]i accumulation in these cells.	Hydrogen	19-21	natriuretic peptide C	Rattus norvegicus	141-144
11196968-5	2000	The linear oxo-bridged [(OReCl2(biimH2)2(mu-O)] complex obtained with nonmethylated biimidazole includes two Cl- ions held via N-H...Cl- hydrogen bonds, leading to a dianionic [(OReCl2(biimH2...Cl)2(mu-O)]2- unit in the crystals of the PPh4+ salt.	Hydrogen	137-145	potassium two pore domain channel subfamily K member 3	Homo sapiens	236-240
18236493-5	2008	Docking of representative compounds into a homology model of human aromatase assists in the rationalisation of the SAR derived from the in vitro biological results and supports a crucial role for a cyano group on the "A" phenyl ring, which is accessible to hydrogen bond interactions with Ser 478.	Hydrogen	257-265	sarcosine dehydrogenase	Homo sapiens	115-118
32690595-9	2020	A proline substitution in the alpha-helix, found in mouse LPL, is expected to interfere with several hydrogen bonds, explaining why 5D2 cannot bind to mouse LPL.	Hydrogen	101-109	lipoprotein lipase	Mus musculus	58-61
32927386-2	2020	Here, we introduce a new quasi-one-dimensional chain of spin-1/2 1H nuclei in hambergite (Be2BO3(OH)) crystal.	Hydrogen	65-67	spindlin 1	Homo sapiens	56-64
10901712-3	2000	The Catalyst models generated from multiple conformers of competitive inhibitors of CYP2C9 activities contained at least one hydrophobic and two hydrogen bond acceptor/donor regions.	Hydrogen	145-153	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	84-90
32649952-5	2020	In the current study, based on 1H-15N HSQC NMR experiments and HADDOCK results, S100A4 interacts with the intrinsically unstructured transactivation domain (TAD) of the protein p53 and the pentamidine molecules in the presence of calcium ions.	Hydrogen	31-33	S100 calcium binding protein A4	Homo sapiens	80-86
18288871-6	2008	Adsorption of CO on the Pt/C and Pt-B resulted in growth of a sharp nu(OH) band around 3642-3645 cm(-1) which is assigned to non-hydrogen-bonded water molecules coadsorbed with CO.	Hydrogen	129-137	polypyrimidine tract binding protein 1	Homo sapiens	33-37
18157556-2	2008	In this study, the effect of nitric oxide (NO) on metal release (using Cd2+ as a probe) from MT-3 was examined by 113Cd and 2D [1H-15N] heteronuclear single-quantum coherence NMR spectroscopy.	Hydrogen	128-130	metallothionein 3	Homo sapiens	93-97
10956187-2	2000	O6-Cyclohexylmethylguanine (NU2058) was a competitive inhibitor of CDK1 and CDK2 with respect to ATP (Ki values: CDK1, 5 +/- 1 microM; CDK2, 12 +/- 3 microM) and formed a triplet of hydrogen bonds (i.e., NH-9 to Glu 81, N-3 to Leu 83, and 2-NH2 to Leu 83).	Hydrogen	182-190	cyclin dependent kinase 1	Homo sapiens	67-71
17912758-7	2008	The XPF HhH homodimer has a larger interaction interface, aromatic stacking interactions, and additional hydrogen bond contacts as compared to the XPF/ERCC1 HhH complex, which accounts for its higher stability.	Hydrogen	105-113	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	4-7
32881488-3	2020	Experimental data corroborated by theory calculations demonstrate that intramo-lecular hydrogen bonding can stabilize Boat whereas electron repulsive interaction from opposing ester substituents favors Chair.	Hydrogen	87-95	ataxin 1 like	Homo sapiens	118-122
32881488-4	2020	Intramolecular hydrogen bonding, formed by 1,10-diamide substitution stabilizes Boat, spiking the temperature at which Boat and Chair can readily interchange from -60  C to 60  C. Concomitantly this intramolecular attraction raises the energy barrier from 42 kJ/mol of unsubstituted DBCOD to 68 kJ/mol of diamide-substituted DBCOD.	Hydrogen	15-23	ataxin 1 like	Homo sapiens	80-84
32881488-4	2020	Intramolecular hydrogen bonding, formed by 1,10-diamide substitution stabilizes Boat, spiking the temperature at which Boat and Chair can readily interchange from -60  C to 60  C. Concomitantly this intramolecular attraction raises the energy barrier from 42 kJ/mol of unsubstituted DBCOD to 68 kJ/mol of diamide-substituted DBCOD.	Hydrogen	15-23	ataxin 1 like	Homo sapiens	119-123
18156175-4	2008	The binding affinities of beta3 integrin tails for the Dok1 and talin phosphotyrosine binding domains were quantified using 15N-1H hetero-nuclear single quantum correlation titrations, revealing that the unphosphorylated integrin tail binds more strongly to talin than Dok1.	Hydrogen	128-130	docking protein 1	Homo sapiens	55-59
18164311-4	2008	The LadA:FMN binary complex structure and a LadA:FMN:alkane model reveal a hydrophobic cavity that has dual roles: to provide a hydrogen-bond donor (His138) for catalysis and to create a solvent-free environment in which to stabilize the C4a-hydroperoxyflavin intermediate.	Hydrogen	128-136	ladinin 1	Homo sapiens	4-8
10956187-3	2000	The triplet of hydrogen bonding and CDK inhibition was reproduced by 2,6-diamino-4-cyclohexylmethyloxy-5-nitrosopyrimidine (NU6027, Ki values: CDK1, 2.5 +/- 0.4 microM; CDK2, 1.3 +/- 0.2 microM).	Hydrogen	15-23	cyclin dependent kinase 1	Homo sapiens	143-147
18164311-4	2008	The LadA:FMN binary complex structure and a LadA:FMN:alkane model reveal a hydrophobic cavity that has dual roles: to provide a hydrogen-bond donor (His138) for catalysis and to create a solvent-free environment in which to stabilize the C4a-hydroperoxyflavin intermediate.	Hydrogen	128-136	ladinin 1	Homo sapiens	44-48
11040966-4	2000	It was shown that approximately 54 apolipoprotein A-I molecules carrying tetrahydrocortisol as a ligand bind to one molecule of isolated native DNA, inducing a break of hydrogen bonds between the pair of nitrous bases.	Hydrogen	169-177	apolipoprotein A1	Rattus norvegicus	35-53
18478689-1	2008	We report the first 1H and 43Ca NMR characterization of Ca2+ ion binding to G-quartets.	Hydrogen	20-22	carbonic anhydrase 2	Homo sapiens	56-59
33024898-5	2021	Mechanistically, the architecture of Da-g-Xan hydrogel is maintained by dynamic intermolecular hydrogen bonds that allow the quick release of Da-g-Xan.	Hydrogen	95-103	clusterin	Rattus norvegicus	37-41
33024898-5	2021	Mechanistically, the architecture of Da-g-Xan hydrogel is maintained by dynamic intermolecular hydrogen bonds that allow the quick release of Da-g-Xan.	Hydrogen	95-103	clusterin	Rattus norvegicus	142-146
10884290-6	2000	This reduction corresponds to a decrease in free energy of binding of approximately 600 cal/mol, consistent with the elimination of a hydrogen-bonded ion pair (salt bridge) between a lysine on apoE and an acidic residue on the LDLR.	Hydrogen	134-142	low density lipoprotein receptor	Homo sapiens	227-231
32743632-7	2020	For the binding of PFBA and PFOA to the GPER, DeltaH > 0 and DeltaS > 0, indicating that the interaction was mainly driven by hydrophobic forces; for the binding of PFDoA to the GPER, DeltaH < 0 and DeltaS < 0, suggesting that van der Waals force and hydrogen bonding were the main interaction forces.	Hydrogen	251-259	G protein-coupled estrogen receptor 1	Homo sapiens	40-44
32743632-9	2020	Molecular docking analysis showed that all three PFCAs could form hydrogen bonds with the GPER, which improved the stability of the complex.	Hydrogen	66-74	G protein-coupled estrogen receptor 1	Homo sapiens	90-94
32773036-2	2020	Hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS) was used to map the membrane and NDP52 binding sites of the ULK1 complex to unique regions of the coiled coil of the FIP200 subunit.	Hydrogen	0-8	RB1 inducible coiled-coil 1	Homo sapiens	183-189
18247957-5	2008	The type of an anionic 5(")-dAMPH state, i.e., the valence, dipole bound, or mixed (valence/dipole bound), depends on the internal hydrogen bond(s) pattern exhibited by a particular tautomer.	Hydrogen	131-139	Amphiphysin	Drosophila melanogaster	28-33
18218891-3	2008	We demonstrate techniques, using magnetic resonance imaging and para-hydrogen (p-H2) polarization, that allow direct visualization of gas-phase flow and the density of active catalyst in a packed-bed microreactor, as well as control over the dynamics of the polarized state in space and time to facilitate the study of subsequent reactions.	Hydrogen	69-77	polyhomeotic homolog 2	Homo sapiens	79-83
11232832-2	2000	For the latter method, an intermediate species formulated as Pd2(dppm)4(O2CH)2(2+) is identified spectroscopically (1H NMR, 31P NMR, IR, and FAB-MS).	Hydrogen	116-118	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	61-64
18399242-1	2008	Hydrogen atom abstraction reactions have been implicated in oxygenation reactions catalyzed by copper monooxygenases such as peptidylglycine alpha-hydroxylating monooxygenase (PHM) and dopamine beta-monooxygenase (DbetaM).	Hydrogen	0-8	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	125-174
18399242-1	2008	Hydrogen atom abstraction reactions have been implicated in oxygenation reactions catalyzed by copper monooxygenases such as peptidylglycine alpha-hydroxylating monooxygenase (PHM) and dopamine beta-monooxygenase (DbetaM).	Hydrogen	0-8	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	176-179
32298752-7	2020	Molecular modeling exhibited potential interaction between PhGs and the Nrf2 binding site in Kelch-like ECH-association protein 1 (Keap1), and hydrogen bonds played a crucial role for the binding of PhGs with Keap1.	Hydrogen	143-151	kelch-like ECH-associated protein 1	Mus musculus	209-214
18767124-3	2008	The structure of a hybrid alphagammaalphaalphagammaalpha peptide, Boc-Leu-Gpn-Aib-Leu-Gpn-Aib-OMe in crystals reveals a continuous helical conformation stabilized by three intramolecular 4 --&gt; 1 C(12) hydrogen bonds across the alphagamma/alphagamma segments and one C(10) hydrogen bond across the central alphaalpha segment.	Hydrogen	204-212	ANIB1	Homo sapiens	78-81
10799511-3	2000	The complex possesses some novel features, including an extensive network of hydrogen bonds involving the main chain of residues 101, 103, and 236 of the p66 reverse transcriptase subunit.	Hydrogen	77-85	DNA polymerase delta 3, accessory subunit	Homo sapiens	154-157
18767124-3	2008	The structure of a hybrid alphagammaalphaalphagammaalpha peptide, Boc-Leu-Gpn-Aib-Leu-Gpn-Aib-OMe in crystals reveals a continuous helical conformation stabilized by three intramolecular 4 --&gt; 1 C(12) hydrogen bonds across the alphagamma/alphagamma segments and one C(10) hydrogen bond across the central alphaalpha segment.	Hydrogen	204-212	ANIB1	Homo sapiens	90-93
18767124-3	2008	The structure of a hybrid alphagammaalphaalphagammaalpha peptide, Boc-Leu-Gpn-Aib-Leu-Gpn-Aib-OMe in crystals reveals a continuous helical conformation stabilized by three intramolecular 4 --&gt; 1 C(12) hydrogen bonds across the alphagamma/alphagamma segments and one C(10) hydrogen bond across the central alphaalpha segment.	Hydrogen	275-283	ANIB1	Homo sapiens	78-81
18767124-3	2008	The structure of a hybrid alphagammaalphaalphagammaalpha peptide, Boc-Leu-Gpn-Aib-Leu-Gpn-Aib-OMe in crystals reveals a continuous helical conformation stabilized by three intramolecular 4 --&gt; 1 C(12) hydrogen bonds across the alphagamma/alphagamma segments and one C(10) hydrogen bond across the central alphaalpha segment.	Hydrogen	275-283	ANIB1	Homo sapiens	90-93
10725379-0	2000	Enhanced visibility of hydrogen atoms by neutron crystallography on fully deuterated myoglobin.	Hydrogen	23-31	myoglobin	Homo sapiens	85-94
18052134-6	2007	Since the resulting proton-transferred hydrogen-bonded complex (O2...H3O+) consists of weakly bound molecular oxygen, it might have important implications in various chemical processes and aquatic life systems.	Hydrogen	39-47	H3 clustered histone 15	Homo sapiens	69-72
10826889-0	2000	Letter to the editor: 1H, 15N and 13C resonance assignments for the catalytic domain of the yeast E2, UBC1.	Hydrogen	22-24	E2 ubiquitin-conjugating protein UBC1	Saccharomyces cerevisiae S288C	102-106
17601747-5	2007	Finally, the 15N-1H HSQC spectrum of uniformly 15N-labeled MMP-12 catalytic domain indicates the presence of well-ordered and properly folded protein in a monomeric form.	Hydrogen	17-19	matrix metallopeptidase 12	Homo sapiens	59-65
18052446-3	2007	At all the investigated surface temperatures, T(S) (300-1400 K), we found the bulk oxygen concentration C(O) to have a strong effect on the integral probability, alpha(H(2) ), of dissociative sticking of H(2) molecules followed by hydrogen solution in the metal lattice: alpha(H(2) ) monotonically decreased by orders of magnitude with increasing C(O) from 0.03 to 1.5 at.	Hydrogen	231-239	relaxin 2	Homo sapiens	162-172
10770485-2	2000	Transmembrane helix (TMH) 7 of LHR is amphipathic, with an extended face containing only hydrophobic side chains and another containing both hydrophobic and polar side chains with potential hydrogen bond donor and acceptor functions.	Hydrogen	190-198	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	31-34
10739114-10	2000	An analysis of the putative transmembrane alpha-helices of MRP1 and P-gp reveals that the amino acid residues with hydrogen-bond donor side chains are arranged preferentially on one side of the helix and amino acid residues with inert (non-hydrogen-bonding) side chains on the other side.	Hydrogen	115-123	phosphoglycolate phosphatase	Homo sapiens	68-72
10739114-10	2000	An analysis of the putative transmembrane alpha-helices of MRP1 and P-gp reveals that the amino acid residues with hydrogen-bond donor side chains are arranged preferentially on one side of the helix and amino acid residues with inert (non-hydrogen-bonding) side chains on the other side.	Hydrogen	240-248	phosphoglycolate phosphatase	Homo sapiens	68-72
10739114-12	2000	CONCLUSIONS: We propose that P-gp and MRP1 recognize type I or type II units in chemical compounds having diverse structures, and that these transporters bind their substrates via hydrogen bond formation.	Hydrogen	180-188	phosphoglycolate phosphatase	Homo sapiens	29-33
10653645-1	2000	In thymidylate synthase, four conserved arginines provide two hydrogen bonds each to the oxygens of the phosphate group of the substrate, 2"-deoxyuridine-5"-monophosphate.	Hydrogen	62-70	thymidylate synthetase	Homo sapiens	3-23
10813890-1	2000	tert-Alkoxyl radicals generated from the thermolysis underwent the unimolecular reactions, beta-scission, and 1,5-H shift, competing with hydrogen abstraction from cumene.	Hydrogen	138-146	telomerase reverse transcriptase	Homo sapiens	0-4
11263244-6	2000	The N-terminal residues (especially Met1 and Gln4) of human CCR5 contacted with CD4 residues, mainly with one span (56-59) of CD4 in electrostatic interaction and hydrogen-bonds.	Hydrogen	163-171	granzyme M	Homo sapiens	36-40
11263244-8	2000	On the other hand, direct interatomic contacts were made between 7 CCR5 residues and 6 gp120 amino-acid residues, which included van der Waals contacts, hydrophobic interaction, and hydrogen bonds.	Hydrogen	182-190	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	87-92
10649374-1	2000	An MP2 ab initio study of the interaction between a H(2)O molecule and trans-[Pt(OH)(2)(NH(3))(2)] revealed a HO-H small middle dot small middle dot small middle dotPt(II) hydrogen bond (see picture) with a strong dispersion component (ca.	Hydrogen	172-180	tryptase pseudogene 1	Homo sapiens	3-6
10639280-4	1999	Small substituents such as hydrogen and fluorine are preferred at the C-2" position.	Hydrogen	27-35	complement C2	Homo sapiens	70-73
10581257-5	1999	Specifically, the first cysteine of RING-H2 is required for the ubiquitylation activity of the Ubr1p-Ubc2p complex, although this cysteine plays no detectable role in either the binding of N-end rule substrates by Ubr1p or the physical affinity between Ubr1p and Ubc2p.	Hydrogen	41-43	E3 ubiquitin-protein ligase UBR1	Saccharomyces cerevisiae S288C	95-100
10581257-5	1999	Specifically, the first cysteine of RING-H2 is required for the ubiquitylation activity of the Ubr1p-Ubc2p complex, although this cysteine plays no detectable role in either the binding of N-end rule substrates by Ubr1p or the physical affinity between Ubr1p and Ubc2p.	Hydrogen	41-43	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	101-106
10581257-5	1999	Specifically, the first cysteine of RING-H2 is required for the ubiquitylation activity of the Ubr1p-Ubc2p complex, although this cysteine plays no detectable role in either the binding of N-end rule substrates by Ubr1p or the physical affinity between Ubr1p and Ubc2p.	Hydrogen	41-43	E3 ubiquitin-protein ligase UBR1	Saccharomyces cerevisiae S288C	214-219
10581257-5	1999	Specifically, the first cysteine of RING-H2 is required for the ubiquitylation activity of the Ubr1p-Ubc2p complex, although this cysteine plays no detectable role in either the binding of N-end rule substrates by Ubr1p or the physical affinity between Ubr1p and Ubc2p.	Hydrogen	41-43	E3 ubiquitin-protein ligase UBR1	Saccharomyces cerevisiae S288C	214-219
10581257-5	1999	Specifically, the first cysteine of RING-H2 is required for the ubiquitylation activity of the Ubr1p-Ubc2p complex, although this cysteine plays no detectable role in either the binding of N-end rule substrates by Ubr1p or the physical affinity between Ubr1p and Ubc2p.	Hydrogen	41-43	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	263-268
10585222-6	1999	When the amino group acts as a hydrogen bond acceptor, there is a shielding effect on C-4 to the extent of ca.	Hydrogen	31-39	complement C4A (Rodgers blood group)	Homo sapiens	86-89
10515590-5	1999	70 kcal/mol), suggesting that the C-2 hydrogen can be abstracted by free radicals.	Hydrogen	38-46	complement C2	Homo sapiens	34-37
10563569-12	1999	The bis-intercalation of the thiazole orange dye TOTO to the LNA duplex was also investigated by 1H NMR spectroscopy to sense the structural change from the unmodified oligonucleotide.	Hydrogen	97-99	HOP homeobox	Homo sapiens	49-53
10491308-2	1999	The guanine base can form two specific hydrogen bonds with the active site residues Ser(121) and Val(73) and the attached negatively charged phosphate groups can entertain stabilizing electrostatic interactions with two clusters of positively charged patches on the PAP surface formed by Lys(210) and Arg(179) from one side and Arg(122) and Arg(135) from the other side of the active site.	Hydrogen	39-47	regenerating family member 3 alpha	Homo sapiens	266-269
32762484-9	2020	In vitro experiments showed that hydrogen-rich medium mitigated the CT-1-induced cardiomyocyte hypertrophy with a similar effect as the JAK specific antagonists AG490.	Hydrogen	33-41	cardiotrophin 1	Rattus norvegicus	68-72
10596454-15	1999	Our data suggest that highly conserved arginine residues are required to stabilize the tertiary structure of annexin V by establishing hydrogen bonds and ionic bridges.	Hydrogen	135-143	annexin A5	Homo sapiens	109-118
32126881-8	2020	The life time of hydrogen bond made between the complex of ALK and Met1199 was also stable in 63%.	Hydrogen	17-25	ALK receptor tyrosine kinase	Homo sapiens	59-62
10398365-0	1999	Conformational dynamics of cytochrome c: correlation to hydrogen exchange.	Hydrogen	56-64	cytochrome c, somatic	Equus caballus	27-39
32608963-4	2020	The vast number of hydrophilic hydroxyl groups on the surface of CNF and paper fibers enables fast water molecules exchange between the humidity sensitive material and the external environment via hydrogen bonding, endowing the paper-based sensor with an excellent humidity responsive property.	Hydrogen	197-205	NPHS1 adhesion molecule, nephrin	Homo sapiens	65-68
10350625-10	1999	For cholesterol esterase, carbamates 8-10 are more potent than carbamates S-2, 4, and 5 probably due to the fact that the inhibitor molecules interact with the second alkyl chain binding site of the enzyme through a hydrogen bond between the phenol hydroxy group of the inhibitor molecules and the His 435 residue in that site.	Hydrogen	216-224	carboxyl ester lipase	Homo sapiens	4-24
32639724-6	2020	1H NMR (Lu3+) and spectrophotometric titrations of the isolated [TbL1]- complex by EuCl3 salts demonstrated the formation of high-order (hetero)polymetallic species in aqueous solution (H2O, pH = 7).	Hydrogen	0-2	transducin beta like 1 Y-linked	Homo sapiens	65-69
10447715-8	1999	Thus, we propose that Trx-dependent IgG proteolysis occurred, on the one hand by means of the unfolding of the IgG after disulphide reduction, becoming a substrate of lysosomal proteases, and on the other hand by Cys-proteases such as cathepsin B that are fully active upon the regeneration of their activity by hydrogen donors.	Hydrogen	312-320	thioredoxin	Homo sapiens	22-25
10215663-8	1999	A charge interaction between mexiletine and the Asp313 side chain in the CYP1A2 active site was found, and varying degrees of hydrogen bond formation between these three compounds and the CYP1A2 active site were observed.	Hydrogen	126-134	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	188-194
32530077-0	2020	Experimental and Theoretical Evidence of Spin-Orbit Heavy Atom on the Light Atom 1 H NMR Chemical Shifts Induced through H   I- Hydrogen Bond.	Hydrogen	128-136	spindlin 1	Homo sapiens	41-45
32551707-3	2020	Interestingly, the spin-spin couplings in the 1H NMR spectrum were not as expected at 1st order.	Hydrogen	46-48	spindlin 1	Homo sapiens	19-23
17915885-3	2007	Treatment of the resulting 2-deoxy-2-thiotolyl-glycosides with hydrogen and Raney nickel affords the corresponding 2-deoxy-furanosides with a 1,3-syn relationship.	Hydrogen	63-71	synemin	Homo sapiens	146-149
10213609-0	1999	Engineering out motion: a surface disulfide bond alters the mobility of tryptophan 22 in cytochrome b5 as probed by time-resolved fluorescence and 1H NMR experiments.	Hydrogen	147-149	cytochrome b5 type A	Homo sapiens	89-102
17892302-7	2007	1H-15N TROSY NMR experiments indicated that LMPG micelles are well-suited for structural studies of KCNE1, leading to assignment of its backbone resonances and to relaxation studies.	Hydrogen	0-2	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	100-105
32551707-3	2020	Interestingly, the spin-spin couplings in the 1H NMR spectrum were not as expected at 1st order.	Hydrogen	46-48	spindlin 1	Homo sapiens	24-28
32619162-7	2021	p28 interacted with all the three viral proteins and the host ACE-2 receptor by forming several electrostatic and hydrogen bonds with the S-protein, 3CLpro, and PLpro.	Hydrogen	114-122	golgi SNAP receptor complex member 1	Homo sapiens	0-3
10499107-5	1999	The Fe-C and C-O vibrational frequencies of CO-myoglobin have also been studied and the results indicate that CO forms hydrogen bonds to either the distal histidine residue or a water molecule during normal conditions.	Hydrogen	119-127	myoglobin	Homo sapiens	47-56
17573054-9	2007	Finally, the particularly low hydrophilicity of beta-D-talose appears to be caused by the formation of a high-occurrence hydrogen-bonded bridge between the 1,3-syn-diaxial 2-OH and 4-OH groups.	Hydrogen	121-129	synemin	Homo sapiens	160-163
32511903-0	2020	A (Thio)Urea-based Covalent Organic Framework as A Hydrogen-Bond-Donating Catalyst.	Hydrogen	51-59	acetyl-CoA acyltransferase 1	Homo sapiens	3-7
9888816-0	1999	Binding of nucleotides by the mitochondrial ADP/ATP carrier as studied by 1H nuclear magnetic resonance spectroscopy.	Hydrogen	74-76	WD and tetratricopeptide repeats 1	Homo sapiens	44-59
32371117-6	2020	Docking studies, confirmed that, the sulfonamide SO2 oxygen was involved in a hydrogen bond with Lys162 and Lys122 in AURKA and AURKB, respectively, whereas, the sulfonamide NH could catch hydrogen bond interaction with the surrounding amino acid residues Lys141, Glu260, and Asn261 in AURKA and Lys101, Glu177, and Asp234 in AURKB.	Hydrogen	78-86	aurora kinase B	Homo sapiens	128-133
32371117-6	2020	Docking studies, confirmed that, the sulfonamide SO2 oxygen was involved in a hydrogen bond with Lys162 and Lys122 in AURKA and AURKB, respectively, whereas, the sulfonamide NH could catch hydrogen bond interaction with the surrounding amino acid residues Lys141, Glu260, and Asn261 in AURKA and Lys101, Glu177, and Asp234 in AURKB.	Hydrogen	189-197	aurora kinase B	Homo sapiens	128-133
32371117-6	2020	Docking studies, confirmed that, the sulfonamide SO2 oxygen was involved in a hydrogen bond with Lys162 and Lys122 in AURKA and AURKB, respectively, whereas, the sulfonamide NH could catch hydrogen bond interaction with the surrounding amino acid residues Lys141, Glu260, and Asn261 in AURKA and Lys101, Glu177, and Asp234 in AURKB.	Hydrogen	189-197	aurora kinase B	Homo sapiens	326-331
17517919-3	2007	The data suggest that IFN afacon-1 has 9 optimal interactions with IFNAR2, comprising hydrophobic, electrostatic, and hydrogen bonding.	Hydrogen	118-126	interferon alpha and beta receptor subunit 2	Homo sapiens	67-73
17385234-5	2007	The relative crystalline degrees of PCL/TiO(2) hybrid nanocomposite materials were controlled by both inorganic component and hydrogen bonding special interaction.	Hydrogen	126-134	PHD finger protein 1	Homo sapiens	36-39
32371117-7	2020	Furthermore, N1 nitrogen of the quinoline scaffold formed an essential hydrogen bond with the hinge region key amino acids Ala213 and Ala173 in AURKA and AURKB, respectively.	Hydrogen	71-79	aurora kinase B	Homo sapiens	154-159
9888816-1	1999	Nucleotide binding to the cytosolic binding site of the mitochondrial ADP/ATP carrier (AAC) was studied by 1H-nuclear magnetic resonance spectroscopy.	Hydrogen	107-109	WD and tetratricopeptide repeats 1	Homo sapiens	70-85
11670822-4	1998	An extra hydrogen atom in 2-4 has been confirmed by FAB mass spectra.	Hydrogen	9-17	FA complementation group B	Homo sapiens	52-55
32361189-9	2020	Importantly, hydrogen treatment prevented mitochondrial depolarization, cytochrome c release, and activity of caspase-3, caspase-9, and PARP.	Hydrogen	13-21	caspase 3	Mus musculus	110-119
32361189-9	2020	Importantly, hydrogen treatment prevented mitochondrial depolarization, cytochrome c release, and activity of caspase-3, caspase-9, and PARP.	Hydrogen	13-21	poly (ADP-ribose) polymerase family, member 1	Mus musculus	136-140
32361189-10	2020	Moreover, the decreased expression of Bcl-xl and Bcl-2 and the increased expression of Bax protein were also blocked by hydrogen treatment.	Hydrogen	120-128	BCL2-associated X protein	Mus musculus	87-90
17764198-4	2007	Interesting differences were noted in 1H NMR spectra of the series 1 (syn) diol epoxides of benzo[c]phenanthrene (BcPh) and 1,4-DFBcPh; the BcPh diol epoxide displays a quasi-diequatorial orientation of the hydroxyl groups, but in the 1,4-DFBcPh case these are diaxially disposed.	Hydrogen	38-40	synemin	Homo sapiens	70-73
17718528-4	2007	The metal particle dimensions decrease in the order CH4/O2 &gt; H2 &gt; CH4/H2O &gt; CO &gt; CO/H2.	Hydrogen	76-78	EBP cholestenol delta-isomerase	Homo sapiens	52-58
9832616-5	1998	The three strands are held together by the (Gly) N-H O (Pro-X) hydrogen bond interactions, and additional stability is provided by the (Pro-Y) Calpha -H O (Pro-X) hydrogen bonding interactions.	Hydrogen	163-171	pyruvate dehydrogenase complex component X	Homo sapiens	136-161
17496029-1	2007	In the cytochrome c-551 family, the heme 17-propionate caboxylate group is always hydrogen bonded to an invariant Trp-56 and conserved residues (His and Arg mainly, Lys occasionally) at position 47.	Hydrogen	82-90	cytochrome c3 family protein	Pseudomonas stutzeri	7-19
17496029-2	2007	The mutation of His-47 to Ala-47 for Pseudomas stutzeri ZoBell cytochrome c-551 removes this otherwise invariant hydrogen bond.	Hydrogen	113-121	cytochrome c3 family protein	Pseudomonas stutzeri	63-75
17608414-4	2007	Detailed spectral studies including 1H NMR and MALDI-TOF mass spectroscopy reveal the unusual formation of a tetramercury complex with the ligand, in which the four propyl arms containing the quinolinoloxy groups adopt a "tetrapodand" conformation enclosing one Hg2+ ion each in the four cavities thus formed.	Hydrogen	36-38	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	262-265
32145391-6	2020	Purified CCL7 not only maintains a well-folded three-dimensional structure as analyzed using circular dichroism and 1H/15N NMR but it also induces coupling of heterotrimeric G-proteins and beta-arrestins for selected chemokine receptors in cellular system.	Hydrogen	116-118	C-C motif chemokine ligand 7	Homo sapiens	9-13
32469293-7	2021	The interactions between HGD and morin involve hydrogen bonding and/or van der Waals forces.	Hydrogen	47-55	homogentisate 1,2-dioxygenase	Homo sapiens	25-28
17521911-4	2007	Modifications at position 7 were designed to exploit the importance of the hydrogen bond accepting properties of this heteroatom in modulating the adenosine deaminase (ADA) mediated 6-N deamination.	Hydrogen	75-83	adenosine deaminase	Homo sapiens	147-166
9828009-0	1998	Sequential assignment of 1H, 15N, 13C resonances and secondary structure of human calmodulin-like protein determined by NMR spectroscopy.	Hydrogen	25-27	calmodulin like 3	Homo sapiens	82-105
17521911-4	2007	Modifications at position 7 were designed to exploit the importance of the hydrogen bond accepting properties of this heteroatom in modulating the adenosine deaminase (ADA) mediated 6-N deamination.	Hydrogen	75-83	adenosine deaminase	Homo sapiens	168-171
17521911-6	2007	Position 7 of the nucleobase proved to be an effective handle for modulating ADA-mediated degradation, with the rate of degradation correlating with the hydrogen-bonding properties at this position.	Hydrogen	153-161	adenosine deaminase	Homo sapiens	77-80
17345571-10	2007	The reaction paths were promoted by a hydrogen-bond circuit of H3O+(H2O)2 and were determined as completely concerted processes.	Hydrogen	38-46	H3 clustered histone 15	Homo sapiens	63-66
32458917-6	2020	Analysis of reaction mixtures leading to the formation of the MBBP analogs [(MBBP)Ni(R2-1,3-diketonate)]X (X = ClO4: 5: R = CH3; 6: R = C(CH3)3; 7-ClO4: R = Ph; X = Cl: 7-Cl: R = Ph) using 1H NMR and ESI-MS revealed the presence of [(MBBP)2Ni](ClO4)2 (8).	Hydrogen	189-191	splicing factor 1	Homo sapiens	62-66
9828013-4	1998	The results we obtain indicate that oxidized Cyt c is 2.0 kcal mol(-1) less stable than the reduced form, and 0.07 kcal mol(-1) is more stable than the Cyt c: azide complex at 25 degrees C. These values agree in magnitude with results from hydrogen exchange and unfolding studies, suggesting that the stability of a protein can be directly related to its structural dynamics.	Hydrogen	240-248	cytochrome c, somatic	Equus caballus	45-50
9828013-4	1998	The results we obtain indicate that oxidized Cyt c is 2.0 kcal mol(-1) less stable than the reduced form, and 0.07 kcal mol(-1) is more stable than the Cyt c: azide complex at 25 degrees C. These values agree in magnitude with results from hydrogen exchange and unfolding studies, suggesting that the stability of a protein can be directly related to its structural dynamics.	Hydrogen	240-248	cytochrome c, somatic	Equus caballus	152-157
32302140-3	2020	The succinimide was identified as a key potency-driving motif, forming two strong hydrogen-bonds to the allosteric pocket of USP7.	Hydrogen	82-90	ubiquitin specific peptidase 7	Homo sapiens	125-129
11672362-3	1998	The cyano group was utilized to introduce a C-8beta angular hydrogen, while the chloro ester moiety served as an entry to the geminal hydrogens at C-4.	Hydrogen	134-143	complement C4A (Rodgers blood group)	Homo sapiens	147-150
17567167-1	2007	Coherent carbon cryogel-ammonia borane (C-AB) nanocomposites were synthesized, and improved H2 storage properties are reported.	Hydrogen	92-94	neural proliferation, differentiation and control 1	Homo sapiens	16-44
19636822-0	2007	Sequence-specific 1H, 13C, and 15N backbone assignment of the GTPase rRheb in its GDP-bound form.	Hydrogen	18-20	Ras homolog, mTORC1 binding	Rattus norvegicus	69-74
9774713-0	1998	Solution structure of a fragment of the dimerization domain of E2F-1 determined by circular dichroism, 1H nuclear magnetic resonance and distance geometry.	Hydrogen	103-105	E2F transcription factor 1	Homo sapiens	63-68
17030007-3	2007	Standard electrode potential of half reaction for p-Q and p-AP were calculated using the sum of electronic and thermal free energies of p-Q and p-AP with normal hydrogen electrode (NHE) as a reference electrode.	Hydrogen	161-169	poly(A) polymerase alpha	Homo sapiens	58-62
32490196-6	2020	Hydrogen atom transfer proceeds via a sigma-channel in AlkBH2-dsDNA and AlkB-dsDNA; in AlkB-ssDNA, there is a competition between sigma- and pi-channels, implying that the nature of the complexed DNA has potential to alter molecular orbital interactions during the substrate oxidation.	Hydrogen	0-8	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	55-59
32490196-6	2020	Hydrogen atom transfer proceeds via a sigma-channel in AlkBH2-dsDNA and AlkB-dsDNA; in AlkB-ssDNA, there is a competition between sigma- and pi-channels, implying that the nature of the complexed DNA has potential to alter molecular orbital interactions during the substrate oxidation.	Hydrogen	0-8	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	72-76
9774713-1	1998	The structure of a synthesized peptide with the sequence GVVDLNWAAEVLKVQKRRIYDITNVLEGIQ which corresponds to residues 149-178 of transcription factor E2F-1 was determined by 1H nuclear magnetic resonance in 40% d3-TFE/water.	Hydrogen	174-176	E2F transcription factor 1	Homo sapiens	150-155
9824237-0	1998	Development of a sensitive and quantitative analytical method for 1H-4-substituted imidazole histamine H3-receptor antagonists utilizing high-performance liquid chromatography and dabsyl derivatization.	Hydrogen	66-68	histamine receptor H3	Rattus norvegicus	93-114
32455924-4	2020	The 1H-NMR profiles highlighted a similar go and return pattern in the metabolism of the BRAF, NRAS, and cKIT mutated cell lines.	Hydrogen	4-6	NRAS proto-oncogene, GTPase	Homo sapiens	95-99
17420132-5	2007	In particular, our data suggest that a narrower active site cleft, together with a different hydrogen bond network arrangement of hCA VA compared to hCA II, may account for the different Kd values of zonisamide and topiramate toward these physiologically relevant hCA isoforms.	Hydrogen	93-101	carbonic anhydrase 5A	Homo sapiens	130-136
9716647-4	1998	The amino acid positions chosen were based upon previous results which demonstrated that human beta2m association with H2-Ld altered the structure of the alpha-1/alpha-2 super-domain.	Hydrogen	119-121	adrenoceptor alpha 1D	Homo sapiens	154-161
32392276-9	2020	In S19, three regions of V306 to K311, C322 to G326, and K331 to G334 form a turn structure, the regions that form the beta-sheet structure in target states S23 and S4, indicating that the formation of a turn structure is necessary to form a beta-sheet structure and then the turn structure will eventually transform into the beta-sheet structure through key hydrogen bonding interactions.	Hydrogen	359-367	ribosomal protein S23	Homo sapiens	157-160
9716647-7	1998	The alteration in H2-Ld structure was evidenced by an increase in the binding of an antibody (34-1-2), specific for the alpha-1 helical region of H2-Ld.	Hydrogen	18-20	adrenoceptor alpha 1D	Homo sapiens	120-127
32087226-7	2020	Compound 5 was found to interact by hydrogen bonding with hMAO-B at Cys172 residue (distance: 3.250 A); no hydrogen bonding was predicted between 5 and hMAO-A.	Hydrogen	36-44	monoamine oxidase B	Homo sapiens	58-64
9680483-0	1998	Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper.	Hydrogen	59-61	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	92-97
9784873-2	1998	1H NMR studies demonstrated that, as anticipated, such a modification induces a shift of the conformational equilibrium toward 1C4 (contribution to the conformational equilibrium rises from 37% to 65%) and a substantial decrease of the affinity for antithrombin III (Kd 0.154 microM versus 0.050 microM).	Hydrogen	0-2	serpin family C member 1	Homo sapiens	249-265
32265297-10	2020	Interestingly, in OTUB2, the catalytic residues His-224 and Asn-226 formed a stable hydrogen bond.	Hydrogen	84-92	OTU deubiquitinase, ubiquitin aldehyde binding 2	Homo sapiens	18-23
31981898-8	2020	We show that these five compounds bind with the hydrophobic cavity of VEGFR2, then forming hydrogen bond interactions with three key residues, Glu-885, Cys-919 and Asp-1046.	Hydrogen	91-99	kinase insert domain receptor	Homo sapiens	70-76
9752004-0	1998	1H, 13C, 15N resonance assignment of the 20 kDa double stranded RNA binding domain of PKR.	Hydrogen	0-2	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	86-89
9714163-0	1998	Stopped-flow NMR measurement of hydrogen exchange rates in reduced horse cytochrome c under strongly destabilizing conditions.	Hydrogen	32-40	cytochrome c, somatic	Equus caballus	73-85
9714163-2	1998	The method has been used to measure exchange rates of a small set of amide hydrogens of reduced cytochrome c, maintained in a strictly anaerobic atmosphere, in the presence of an otherwise inaccessible range of guanidinium deuterochloride concentrations.	Hydrogen	75-84	cytochrome c, somatic	Equus caballus	96-108
9714163-3	1998	The results for the measured protons indicate that hydrogen exchange in the unfolding transition region of cytochrome c reach the EX2 limit, but emphasize the difficulty in interpretation of the exchange mechanism in protein hydrogen exchange studies.	Hydrogen	51-59	cytochrome c, somatic	Equus caballus	107-119
32290322-1	2020	We present a structural and dynamic study on the simplest supramolecular hetero-association, recently investigated by the authors to prepare architectural homogeneous structures in the melt state, based on the bio-inspired hydrogen-bonding of thymine/diaminotriazine (thy-DAT) base-pairs.	Hydrogen	223-231	solute carrier family 6 member 3	Homo sapiens	272-275
9714163-3	1998	The results for the measured protons indicate that hydrogen exchange in the unfolding transition region of cytochrome c reach the EX2 limit, but emphasize the difficulty in interpretation of the exchange mechanism in protein hydrogen exchange studies.	Hydrogen	225-233	cytochrome c, somatic	Equus caballus	107-119
32290322-4	2020	This makes the heterocomplementary thy-DAT association an ideal candidate for further exploitation of the hydrogen-bonding ability in the bulk for self-healing purposes, damage management in rubbers or even the development of easily processable branched polymers with built-in plasticizer.	Hydrogen	106-114	solute carrier family 6 member 3	Homo sapiens	39-42
9714163-4	1998	Comparison of free energies of structure opening for the measured hydrogens with the global unfolding free energy monitored by far-UV CD measurements has indicated the presence of at least one partially unfolded equilibrium species of reduced cytochrome c.	Hydrogen	66-75	cytochrome c, somatic	Equus caballus	243-255
9622485-6	1998	The loss of the hydrogen bond from tyrosine 64 and the increase of the solvent exposure of the heme are probably responsible of the loss of electron transfer between formate dehydrogenase and cytochrome c553.	Hydrogen	16-24	DVUA0098	Desulfovibrio vulgaris str. Hildenborough	174-187
9541406-0	1998	Determinants of protein hydrogen exchange studied in equine cytochrome c.	Hydrogen	24-32	cytochrome c, somatic	Equus caballus	60-72
31505122-12	2020	IL-6 and IL-10 increased with exercise in both study conditions but were increased more(p&lt;0.05) following HYP exercise at Post(+705% and +127%; respectively) and 1h-Post(+400% and +128%; respectively).	Hydrogen	165-167	interleukin 10	Homo sapiens	9-14
9541406-1	1998	The exchange of a large number of amide hydrogens in oxidized equine cytochrome c was measured by NMR and compared with structural parameters.	Hydrogen	40-49	cytochrome c, somatic	Equus caballus	69-81
9452473-5	1998	Interestingly, the serine at position 232 in RARalpha gives an explanation for the observed differences in the affinity of the naturally occurring ligand, all-trans-retinoic acid (t-RA), in this receptor compared with that for the other receptors, since hydrogen bonding would not be permitted between the hydroxyl of serine and the hydrophobic linker of t-RA.	Hydrogen	254-262	retinoic acid receptor alpha	Homo sapiens	45-53
9528658-0	1998	1H-nuclear magnetic resonance evidence for acto-myosin-dependent structural changes of the intracellular water of frog skeletal muscle fiber.	Hydrogen	0-2	myosin heavy chain 14	Homo sapiens	48-54
9710575-3	1998	RESULTS: Hydrogen-exchange labeling coupled with NMR was used to monitor the formation of stable hydrogen-bonded and solvent-excluded structure in horse cytochrome c (cyt c).	Hydrogen	9-17	cytochrome c, somatic	Equus caballus	153-165
9710575-3	1998	RESULTS: Hydrogen-exchange labeling coupled with NMR was used to monitor the formation of stable hydrogen-bonded and solvent-excluded structure in horse cytochrome c (cyt c).	Hydrogen	9-17	cytochrome c, somatic	Equus caballus	167-172
9710575-3	1998	RESULTS: Hydrogen-exchange labeling coupled with NMR was used to monitor the formation of stable hydrogen-bonded and solvent-excluded structure in horse cytochrome c (cyt c).	Hydrogen	97-105	cytochrome c, somatic	Equus caballus	153-165
9710575-3	1998	RESULTS: Hydrogen-exchange labeling coupled with NMR was used to monitor the formation of stable hydrogen-bonded and solvent-excluded structure in horse cytochrome c (cyt c).	Hydrogen	97-105	cytochrome c, somatic	Equus caballus	167-172
9477768-1	1998	We have examined the behavior of radical pairs derived by hydrogen abstraction of triplet benzophenone and some of its derivatives from bovine serum albumin, human serum albumin and calf thymus DNA.	Hydrogen	58-66	albumin	Bos taurus	143-156
9477768-1	1998	We have examined the behavior of radical pairs derived by hydrogen abstraction of triplet benzophenone and some of its derivatives from bovine serum albumin, human serum albumin and calf thymus DNA.	Hydrogen	58-66	albumin	Bos taurus	164-177
9459013-7	1997	However, analysis of the 1H NMR spectra of the incubation products of these two enzymes revealed that, in contrast to the wild-type rSCAD, the Gly368Glu/Gly247Glu rSCAD could not perform gamma-proton exchange of the product with the solvent, a property inherent to most acyl-CoA dehydrogenases.	Hydrogen	25-27	acyl-CoA dehydrogenase short chain	Rattus norvegicus	132-137
9459013-7	1997	However, analysis of the 1H NMR spectra of the incubation products of these two enzymes revealed that, in contrast to the wild-type rSCAD, the Gly368Glu/Gly247Glu rSCAD could not perform gamma-proton exchange of the product with the solvent, a property inherent to most acyl-CoA dehydrogenases.	Hydrogen	25-27	acyl-CoA dehydrogenase short chain	Rattus norvegicus	163-168
9398649-1	1997	The solution structure of the complex of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), a potent mutacarcinogen isolated from tryptophan pyrolysate, with the hexamer duplex d(CGATCG)2, was analysed by 1H-NMR spectroscopy and molecular dynamic calculation.	Hydrogen	209-211	polycystin 1, transient receptor potential channel interacting	Homo sapiens	86-93
17520142-9	2007	Using these correlations it is uncovered that hydrogen abstraction of phenols, as measured by the Delta BDE, is driven by electron transfer rather than by proton transfer.	Hydrogen	46-54	homeobox D13	Homo sapiens	104-107
9367186-12	1997	Hydrogen abstraction from C-4 may be one of the mechanisms of carotenoid antioxidant activity in this system.	Hydrogen	0-8	complement C4A (Rodgers blood group)	Homo sapiens	26-29
17396237-0	2007	1H, 15N and 13C resonance assignments of CG7054, a new PEBP from Drosophila melanogaster.	Hydrogen	0-2	uncharacterized protein	Drosophila melanogaster	41-47
17415668-0	2007	Assignment of 1H, 13C, and 15N resonances for SF2 RNA recognition motif 2.	Hydrogen	14-16	serine and arginine rich splicing factor 1	Homo sapiens	46-49
9351809-6	1997	In addition, the structures show how an arginine residue (Arg77) of Nef interacts with Asp 100 of the so-called RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface.	Hydrogen	162-170	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	131-134
17380482-7	2007	Axin exhibits positional shift in V267G mutant, whereas, losing the hydrogen bonds that are indispensable for stabilizing the helix structure of wild type axin, the helix of axin is distorted in L392P mutant.	Hydrogen	68-76	axin 1	Homo sapiens	155-159
9385550-3	1997	The binding specificity of the three nonapeptides for the two HLA alleles could be explained by the disruption of one hydrogen-bonding network in the binding pocket of the HLA-B*2705 protein where the single mutation occurs.	Hydrogen	118-126	major histocompatibility complex, class I, B	Homo sapiens	172-177
17325006-0	2007	Local polarity and hydrogen bonding inside the Sec14p phospholipid-binding cavity: high-field multi-frequency electron paramagnetic resonance studies.	Hydrogen	19-27	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	47-53
17325006-2	2007	Herein, we employ multi-frequency high-field electron paramagnetic resonance (EPR) to analyze the electrostatic and hydrogen-bonding microenvironments for series of doxyl-labeled PtdCho molecules bound by Sec14p in a soluble protein-PtdCho complex.	Hydrogen	116-124	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	205-211
9254617-18	1997	An FTIR study on the model compound 4-methylbenzoyl S-ethyl thioester, binding to a number of hydrogen bonding donors in CCl4, is described and is used to relate the observed shift of the C=O stretching mode of 4-MeBA-CoA in the active site to the hydrogen bonding strength value.	Hydrogen	248-256	C-C motif chemokine ligand 4	Homo sapiens	121-125
17346964-5	2007	The additional two hydrogen bonds in which N-hydroxysulfamide bound to hCA II is involved as compared to the corresponding adduct of sulfamide may explain its higher affinity for the enzyme, also providing hints for the design of tight-binding CA inhibitors possessing an organic moiety substituting the NH group in the N-hydroxysulfamide structure.	Hydrogen	19-27	carbonic anhydrase 2	Homo sapiens	71-77
9276476-4	1997	1H NMR spectra of the heme and heme ligand resonances of a recombinant tobacco cytochrome b5 extending from Gly1 to Lys89 suggest, in combination with NMR data acquired for other forms of cytochrome b5 and an inspection of their sequence homology, that the identity of residue 78 influences the relative ratios of heme isomers.	Hydrogen	0-2	cytochrome b5	Nicotiana tabacum	79-92
17408804-1	2007	The present studies assessed the extent to which the adiposity signal leptin and the brain-gut hormone cholecystokinin (CCK), administered alone or in combination, give rise to interoceptive sensory cues like those that are produced by a low (1h) level of food deprivation.	Hydrogen	243-245	cholecystokinin	Rattus norvegicus	103-118
17408804-1	2007	The present studies assessed the extent to which the adiposity signal leptin and the brain-gut hormone cholecystokinin (CCK), administered alone or in combination, give rise to interoceptive sensory cues like those that are produced by a low (1h) level of food deprivation.	Hydrogen	243-245	cholecystokinin	Rattus norvegicus	120-123
9276476-4	1997	1H NMR spectra of the heme and heme ligand resonances of a recombinant tobacco cytochrome b5 extending from Gly1 to Lys89 suggest, in combination with NMR data acquired for other forms of cytochrome b5 and an inspection of their sequence homology, that the identity of residue 78 influences the relative ratios of heme isomers.	Hydrogen	0-2	cytochrome b5	Nicotiana tabacum	188-201
9263124-6	1997	For example, the loop region from residues 55-71 of rap-1a makes extensive hydrogen-bond contacts with the RBD, while the same residues of p21 do not.	Hydrogen	75-83	RAP1A, member of RAS oncogene family	Homo sapiens	52-58
17348653-8	2007	Two examples of folded tripeptide structures, Boc-Gpn-betaPhe-Leu-OMe 11 and Boc-Aib-Gpn-betaPhg-NHMe 12, lacking internal hydrogen bonds are also presented.	Hydrogen	123-131	ANIB1	Homo sapiens	81-84
17397254-9	2007	A detailed analysis and interpretation of structural features important for classification shows the relevance of several specific hydrogen-bond donor sites and aliphatic side chains to coreceptor specificity towards CCR5 or CXCR4.	Hydrogen	131-139	C-C motif chemokine receptor 5	Homo sapiens	217-221
17397254-9	2007	A detailed analysis and interpretation of structural features important for classification shows the relevance of several specific hydrogen-bond donor sites and aliphatic side chains to coreceptor specificity towards CCR5 or CXCR4.	Hydrogen	131-139	C-X-C motif chemokine receptor 4	Homo sapiens	225-230
9277136-3	1997	High-resolution gel electrophoresis suggests that cleavage arises from abstraction of a hydrogen atom from C-4" of deoxyribose units.	Hydrogen	88-96	complement C4A (Rodgers blood group)	Homo sapiens	107-110
31900740-0	2020	1H, 13C and 15N backbone resonance assignment of the human BRCA2 N-terminal region.	Hydrogen	0-2	BRCA2 DNA repair associated	Homo sapiens	59-64
32058932-14	2020	Hydrogen treatment decreased the ratio of p-mTOR/mTOR and the expression of p62 and increased the ratio of p-AMPK/AMPK, LC3II/LC3I and the expression of TREM-2 and Beclin-1 in LPS-treated BV-2 cells.	Hydrogen	0-8	nucleoporin 62	Mus musculus	76-79
9223178-4	1997	The stability gap in the FKBP12-FK506 system is determined by two critical water molecules from the effector region that participate in a network of specific hydrogen bond interactions.	Hydrogen	158-166	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	25-31
32058932-14	2020	Hydrogen treatment decreased the ratio of p-mTOR/mTOR and the expression of p62 and increased the ratio of p-AMPK/AMPK, LC3II/LC3I and the expression of TREM-2 and Beclin-1 in LPS-treated BV-2 cells.	Hydrogen	0-8	triggering receptor expressed on myeloid cells 2	Mus musculus	153-159
33542935-12	2020	In the wild-type tyrosinase, the peptide oxygen atom of M374 is responsible for hydrogen bonding with H367.	Hydrogen	80-88	tyrosinase	Homo sapiens	17-27
17275782-3	2007	Lisinopril was effectively stabilized by specific hydrogen bonds and hydrophobic interactions in the active site of MMP-9, and its hydrophobic group appeared to interact preferentially with the S1 site compared with the S1" site.	Hydrogen	50-58	matrix metallopeptidase 9	Homo sapiens	116-121
17263404-4	2007	The neutral complexes form cyclic hydrogen bonds, and the most stable dimers are bound by 17.7 and 16.0 kcal/mol for AFA and MAFA, respectively.	Hydrogen	34-42	AFA	Homo sapiens	117-120
9207946-3	1997	The results of the structure-activity relationship analysis indicate that in highly active compounds the two aryl rings in the hydrophobic moiety deviate from a common plane, so they are capable of interacting with hydrogen bond donors of P-170 glycoprotein (P-gp) via pi-hydrogen-pi interactions.	Hydrogen	215-223	phosphoglycolate phosphatase	Homo sapiens	239-257
17253816-3	2007	Computational studies at the MP2/6-316(d)//B3LYP/6-316(d) level indicate that the prochiral equatorial S-hydrogen is removed preferentially over the pro-R hydrogen, with a difference in transition state activation energies of 1.26 kcal/mol, corresponding to a predicted er of 89:11.	Hydrogen	105-113	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	45-48
17253816-3	2007	Computational studies at the MP2/6-316(d)//B3LYP/6-316(d) level indicate that the prochiral equatorial S-hydrogen is removed preferentially over the pro-R hydrogen, with a difference in transition state activation energies of 1.26 kcal/mol, corresponding to a predicted er of 89:11.	Hydrogen	155-163	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	45-48
17189435-6	2007	Based on results from physiological and genetic experiments, we propose that hydrogen is formed from pyruvate by multiple parallel pathways, one pathway involving formate as an intermediate, pyruvate-formate lyase, and formate-hydrogen lyase, comprised of HydA hydrogenase and formate dehydrogenase, and a formate-independent pathway involving pyruvate dehydrogenase.	Hydrogen	77-85	4Fe-4S dicluster domain-containing protein	Shewanella oneidensis MR-1	256-260
31084417-5	2020	The negative values of thermodynamic parameters (DeltaG, DeltaH and DeltaS) revealed a spontaneous binding process, where hydrogen and van der Waals forces were involved in stabilizing the OVA-C3G complex.	Hydrogen	122-130	Rap guanine nucleotide exchange factor 1	Homo sapiens	193-196
31084417-8	2020	Furthermore, molecular docking and cleavage site prediction studies showed that the hydrogen binding sites of C3G are not near to the cleavage sites of pepsin but partially overlap trypsin cleavages sites in OVA, which might lead to an inhibited effect on pancreatic digestion.	Hydrogen	84-92	Rap guanine nucleotide exchange factor 1	Homo sapiens	110-113
31793068-0	2020	PARP1 hinders histone H2B occupancy at the NFATc1 promoter to restrain osteoclast differentiation.	Hydrogen	22-25	poly (ADP-ribose) polymerase family, member 1	Mus musculus	0-5
31793068-5	2020	These unbiased approaches in conjunction with site-directed mutagenesis studies revealed that PARP1 inhibited NFATc1 expression and OC formation by ADP-ribosylating histone H2B at serine 7 and decreasing the occupancy of this histone variant at the NFATc1 promoter.	Hydrogen	173-176	poly (ADP-ribose) polymerase family, member 1	Mus musculus	94-99
17208193-4	2007	We have investigated the role of the yeast Sdh4p Tyr-89, which forms a hydrogen bond with ubiquinone in the Q(P) site.	Hydrogen	71-79	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	43-48
9207946-3	1997	The results of the structure-activity relationship analysis indicate that in highly active compounds the two aryl rings in the hydrophobic moiety deviate from a common plane, so they are capable of interacting with hydrogen bond donors of P-170 glycoprotein (P-gp) via pi-hydrogen-pi interactions.	Hydrogen	215-223	phosphoglycolate phosphatase	Homo sapiens	259-263
9207946-3	1997	The results of the structure-activity relationship analysis indicate that in highly active compounds the two aryl rings in the hydrophobic moiety deviate from a common plane, so they are capable of interacting with hydrogen bond donors of P-170 glycoprotein (P-gp) via pi-hydrogen-pi interactions.	Hydrogen	272-280	phosphoglycolate phosphatase	Homo sapiens	239-257
9207946-3	1997	The results of the structure-activity relationship analysis indicate that in highly active compounds the two aryl rings in the hydrophobic moiety deviate from a common plane, so they are capable of interacting with hydrogen bond donors of P-170 glycoprotein (P-gp) via pi-hydrogen-pi interactions.	Hydrogen	272-280	phosphoglycolate phosphatase	Homo sapiens	259-263
32108985-0	2020	Hydrogen exerts neuroprotection by activation of the miR-21/PI3K/AKT/GSK-3beta pathway in an in vitro model of traumatic brain injury.	Hydrogen	0-8	microRNA 21	Rattus norvegicus	53-59
9192722-0	1997	Subunit association and monomer structure of CINC/Gro revealed by 1H-NMR.	Hydrogen	66-68	C-X-C motif chemokine ligand 1	Rattus norvegicus	50-53
32108985-2	2020	In this study, we explored neuroprotection of hydrogen-rich medium through activation of the miR-21/PI3K/AKT/GSK-3beta pathway in an in vitro model of traumatic brain injury.	Hydrogen	46-54	microRNA 21	Rattus norvegicus	93-99
32108985-11	2020	Both the miR-21 antagomir and PI3K blocker reversed the protective effect of hydrogen.	Hydrogen	77-85	microRNA 21	Rattus norvegicus	9-15
32108985-12	2020	In conclusion, hydrogen exerted a neuroprotective effect against neuronal apoptosis and impaired nerve regeneration through activation of miR-21/PI3K/AKT/GSK-3beta signalling in this in vitro model of traumatic brain injury.	Hydrogen	15-23	microRNA 21	Rattus norvegicus	138-144
16859959-1	2007	The structures, stability and vibrational spectra of the hydrogen-bonded complexes of carbon monoxide (CO) with phenol and o-cyanophenol (syn and anti) have been studied using ab initio and DFT calculations.	Hydrogen	57-65	synemin	Homo sapiens	138-141
16859959-4	2007	Having in mind the corrected values of the dissociation energy, the studied hydrogen-bonded complexes can be ordered according their stability as follows: 2A-anti&gt;2A-syn&gt;1A&gt;2B-anti&gt;1B&gt;2B-syn.	Hydrogen	76-84	synemin	Homo sapiens	169-172
16859959-4	2007	Having in mind the corrected values of the dissociation energy, the studied hydrogen-bonded complexes can be ordered according their stability as follows: 2A-anti&gt;2A-syn&gt;1A&gt;2B-anti&gt;1B&gt;2B-syn.	Hydrogen	76-84	synemin	Homo sapiens	202-205
17200929-4	2007	The number of structures that contain hydrogens out of the BAl2 ring plane is found to increase from BAl2H3(2-) to BAl2H6+.	Hydrogen	38-47	poly(ADP-ribose) polymerase family member 14	Homo sapiens	59-63
31999919-6	2020	For oligomeric targets, the Interface Patch Similarity (IPS) and Interface Contact Similarity (ICS) averaged over our best oligomer models increased from 0.28 to 0.36 and from 12.4 to 17.8, respectively, from CASP12 to CASP13 and top-ranking models of 2 targets (H0968 and T0997o) were obtained (none in CASP12).	Hydrogen	263-268	caspase 12 (gene/pseudogene)	Homo sapiens	209-215
17393543-5	2007	The crystal structures of Piv-LPro-beta3-Ac6c-NHMe (5) and Boc-Ac6c-Gpn-Ac6c-OMe (6) reveal intramolecularly hydrogen-bonded C11 and C12 conformations, respectively.	Hydrogen	109-117	RNA polymerase III subunit K	Homo sapiens	125-128
9192722-2	1997	Although the three-dimensional structure of CINC/Gro had previously been determined to be that of a dimer with 200 mM NaCl, it was shown on both ultracentrifugation analysis and 1H-NMR spectral analysis that CINC/Gro exists mainly as a monomer at a physiological concentration, similar to other proteins belonging to this family.	Hydrogen	178-180	C-X-C motif chemokine ligand 1	Rattus norvegicus	49-52
9133606-0	1997	Intramembrane signaling mediated by hydrogen-bonding of water and carboxyl groups in bacteriorhodopsin and rhodopsin.	Hydrogen	36-44	rhodopsin	Bos taurus	93-102
17125255-3	2006	As shown by X-ray crystallography, the sulfamide analogue binds to CA II with the deprotonated sulfamide moiety coordinated to Zn(II) and with the organic scaffold making an extended network of hydrogen bonds with Thr199, Gln92, His94, Asn62, and Thr200.	Hydrogen	194-202	carbonic anhydrase 2	Homo sapiens	67-72
17125375-1	2006	A highly efficient photocatalytic system for hydrogen evolution with dihydronicotinamide coenzyme (NADH) as a sacrificial agent in an aqueous solution has been constructed by using water-soluble platinum clusters functionalized with methyl viologen-alkanethiol (MVA2+) and a simple electron-donor dyad, 9-mesityl-10-methylacridinium ion (Acr+-Mes), which is capable of fast photoinduced electron transfer but extremely slow back electron transfer.	Hydrogen	45-53	centrosomal protein 57	Homo sapiens	262-266
17125375-3	2006	As a result, the hydrogen-evolution rate of the photocatalytic system with MVA2+-modified platinum clusters (MVA2+-PtC) is 10 times faster than the photocatalytic system with the mixture of the same amount of MVA2+ and platinum clusters as that of MVA2+-PtC under otherwise the same experimental conditions.	Hydrogen	17-25	centrosomal protein 57	Homo sapiens	75-79
32001262-7	2020	The developed pDIm and mainly pDIdm peptides showed stable conformations over the simulation time with conserved secondary structure and effective interaction with MDM2/X by physical binding such as hydrogen bonding.	Hydrogen	199-207	MDM2 proto-oncogene	Homo sapiens	164-168
31744771-5	2020	We further recognised that the C NMR chemical shifts of the nominal phenyl carbons (C(3)/C(7) and C(4)/C(6)) encode information for intramolecular hydrogen bonding network formed by GA conformers.	Hydrogen	147-155	complement C3	Homo sapiens	84-88
31744771-5	2020	We further recognised that the C NMR chemical shifts of the nominal phenyl carbons (C(3)/C(7) and C(4)/C(6)) encode information for intramolecular hydrogen bonding network formed by GA conformers.	Hydrogen	147-155	complement C7	Homo sapiens	89-93
17125375-3	2006	As a result, the hydrogen-evolution rate of the photocatalytic system with MVA2+-modified platinum clusters (MVA2+-PtC) is 10 times faster than the photocatalytic system with the mixture of the same amount of MVA2+ and platinum clusters as that of MVA2+-PtC under otherwise the same experimental conditions.	Hydrogen	17-25	centrosomal protein 57	Homo sapiens	109-113
17125375-3	2006	As a result, the hydrogen-evolution rate of the photocatalytic system with MVA2+-modified platinum clusters (MVA2+-PtC) is 10 times faster than the photocatalytic system with the mixture of the same amount of MVA2+ and platinum clusters as that of MVA2+-PtC under otherwise the same experimental conditions.	Hydrogen	17-25	centrosomal protein 57	Homo sapiens	109-113
17125375-3	2006	As a result, the hydrogen-evolution rate of the photocatalytic system with MVA2+-modified platinum clusters (MVA2+-PtC) is 10 times faster than the photocatalytic system with the mixture of the same amount of MVA2+ and platinum clusters as that of MVA2+-PtC under otherwise the same experimental conditions.	Hydrogen	17-25	centrosomal protein 57	Homo sapiens	109-113
9097461-7	1997	Immunohistochemistry on siblings shows that the interrenals are immunoreactive for adrenodoxin (adrenal ferredoxin) and cytochrome P-450(21) (steroid 21-monooxygenase [steroid, hydrogen-donor:oxygen oxidoreductase, 21-hydroxylating]; EC 1.14.99.10), and the pituitary for adrenocorticotrophic hormone.	Hydrogen	177-185	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	142-166
16903001-6	2006	Besides the three nearest-neighbor water molecules directly hydrogen-bonded to H3O+, other neighbor waters, such as a fourth water molecule which interacts preferentially with the oxygen atom of the hydronium ion, are found occasionally near the ion.	Hydrogen	60-68	H3 clustered histone 15	Homo sapiens	79-82
32104537-10	2020	These findings suggest that H2 augments cellular antioxidant defense capacity through activation of MAPK signaling pathways, leading to HO-1 expression and subsequent upregulation of PGC-1alpha and SIRT-1 expression.	Hydrogen	28-30	heme oxygenase 1	Rattus norvegicus	136-140
32104537-15	2020	HO-1 plays an important role in H2-mediated protection through the MAPK/HO-1/PGC-1alpha pathway.	Hydrogen	32-34	heme oxygenase 1	Rattus norvegicus	0-4
9067613-8	1997	In particular, the observed hydrogen bonding of these residues to the body of the molecule in the latent form explains the mechanism for the release of newly formed antithrombin-protease complexes into the circulation for catabolic removal.	Hydrogen	28-36	serpin family C member 1	Homo sapiens	165-177
32104537-15	2020	HO-1 plays an important role in H2-mediated protection through the MAPK/HO-1/PGC-1alpha pathway.	Hydrogen	32-34	heme oxygenase 1	Rattus norvegicus	72-76
16828555-5	2006	Based on the molecular interactions observed from 3D structure of 15-PGDH, we further propose that Gln-148 in 15-PGDH is important in properly positioning the 15-hydroxyl group of PGE2 by hydrogen bonding with the side-chain oxygen atom of Gln-148.	Hydrogen	188-196	carbonyl reductase 1	Homo sapiens	66-73
16828555-5	2006	Based on the molecular interactions observed from 3D structure of 15-PGDH, we further propose that Gln-148 in 15-PGDH is important in properly positioning the 15-hydroxyl group of PGE2 by hydrogen bonding with the side-chain oxygen atom of Gln-148.	Hydrogen	188-196	carbonyl reductase 1	Homo sapiens	110-117
16828555-9	2006	This indicates that the side-chain oxygen or nitrogen atom at position 148 of 15-PGDH plays an important role in anchoring C-15 hydroxyl group of PGE2 through hydrogen bonding for catalytic reaction.	Hydrogen	159-167	carbonyl reductase 1	Homo sapiens	78-85
31957446-0	2020	Expression and Purification of Protease-Activated Receptor 4 (PAR4) and Analysis with Histidine Hydrogen-Deuterium Exchange.	Hydrogen	96-104	F2R like thrombin or trypsin receptor 3	Homo sapiens	31-60
9013872-8	1997	1H-15N heteronuclear steady-state NOE measurements on p19 indicate that most of the backbone of p19INK4d exists in a well defined structure of limited conformational flexibility on the nano- to picosecond time scale.	Hydrogen	0-2	cyclin dependent kinase inhibitor 2D	Homo sapiens	54-57
32117873-4	2020	Significantly, the onset dehydrogenation temperature of PMMA-LiBH4/GMF at first step is reduced to 94 C, which is 149 C less than that of LiBH4/GMF, and the PMMA-LiBH4/GMF desorbs 2.9 wt% hydrogen within 25 min at 250 C, which is obviously more than the dehydrogenation amount of LiBH4/GMF under the same conditions.	Hydrogen	27-35	glia maturation factor beta	Homo sapiens	67-70
32117873-4	2020	Significantly, the onset dehydrogenation temperature of PMMA-LiBH4/GMF at first step is reduced to 94 C, which is 149 C less than that of LiBH4/GMF, and the PMMA-LiBH4/GMF desorbs 2.9 wt% hydrogen within 25 min at 250 C, which is obviously more than the dehydrogenation amount of LiBH4/GMF under the same conditions.	Hydrogen	27-35	glia maturation factor beta	Homo sapiens	144-147
32117873-4	2020	Significantly, the onset dehydrogenation temperature of PMMA-LiBH4/GMF at first step is reduced to 94 C, which is 149 C less than that of LiBH4/GMF, and the PMMA-LiBH4/GMF desorbs 2.9 wt% hydrogen within 25 min at 250 C, which is obviously more than the dehydrogenation amount of LiBH4/GMF under the same conditions.	Hydrogen	27-35	glia maturation factor beta	Homo sapiens	144-147
16807956-5	2006	The structures as determined by X-ray crystallography of the hCA II-l-His/d-His adducts showed the activators to be anchored at the entrance of the active site, contributing to extended networks of hydrogen bonds with amino acid residues/water molecules present in the cavity, explaining their different potency and interaction patterns with various isozymes.	Hydrogen	198-206	carbonic anhydrase 2	Homo sapiens	61-67
17168540-7	2006	The structures show that these compounds bind to the Smac-binding site on ML-IAP with identical hydrogen-bonding patterns and similar hydrophobic interactions.	Hydrogen	96-104	baculoviral IAP repeat containing 7	Homo sapiens	74-80
32117873-4	2020	Significantly, the onset dehydrogenation temperature of PMMA-LiBH4/GMF at first step is reduced to 94 C, which is 149 C less than that of LiBH4/GMF, and the PMMA-LiBH4/GMF desorbs 2.9 wt% hydrogen within 25 min at 250 C, which is obviously more than the dehydrogenation amount of LiBH4/GMF under the same conditions.	Hydrogen	27-35	glia maturation factor beta	Homo sapiens	61-70
9013872-8	1997	1H-15N heteronuclear steady-state NOE measurements on p19 indicate that most of the backbone of p19INK4d exists in a well defined structure of limited conformational flexibility on the nano- to picosecond time scale.	Hydrogen	0-2	cyclin dependent kinase inhibitor 2D	Homo sapiens	96-104
32117873-5	2020	It"s our belief that the flexible, water-resistant and air-stable PMMA-LiBH4/GMF with a simple preparation route will provide a new avenue to the research of hydrogen storage materials.	Hydrogen	158-166	glia maturation factor beta	Homo sapiens	77-80
16766622-7	2006	1H-15N chemical shift perturbation experiments indicate that S100A13 can bind simultaneously to both Ca2+ and Cu2+ and the binding of the metal ions is not mutually exclusive.	Hydrogen	0-2	S100 calcium binding protein A13	Homo sapiens	61-68
9030762-1	1997	NMR solution structures of a cytosolic plant thioredoxin h (112 amino acids, 11.7 kDa) from the green alga Chlamydonmonas reinhardtii have been calculated on the basis of 1904 NMR distance restraints, which include 90 distances used to restrain 45 hydrogen bonds, and 44 phi dihedral restraints.	Hydrogen	248-256	thioredoxin	Homo sapiens	45-56
16989530-3	2006	In both cases, the first four conformers showed the N-Me group in the syn orientation, permitting the formation of a hydrogen bond between the hydroxy group at the tropane ring and the tertiary nitrogen atom.	Hydrogen	117-125	synemin	Homo sapiens	70-73
31976659-1	2020	44Sc is an attractive positron-emitting radionuclide for PET imaging; herein, a new complex of the Sc3+ ion with nonmacrocyclic chelator H4pypa was synthesized and characterized with high-resolution electrospray-ionization mass spectrometry (HR-ESI-MS), as well as different nuclear magnetic resonance (NMR) spectroscopic techniques (1H, 13C, 1H-13C HSQC, 1H-13C HMBC, COSY, and NOESY).	Hydrogen	334-336	secretory carrier membrane protein 3	Mus musculus	99-102
31976659-1	2020	44Sc is an attractive positron-emitting radionuclide for PET imaging; herein, a new complex of the Sc3+ ion with nonmacrocyclic chelator H4pypa was synthesized and characterized with high-resolution electrospray-ionization mass spectrometry (HR-ESI-MS), as well as different nuclear magnetic resonance (NMR) spectroscopic techniques (1H, 13C, 1H-13C HSQC, 1H-13C HMBC, COSY, and NOESY).	Hydrogen	343-345	secretory carrier membrane protein 3	Mus musculus	99-102
31976659-1	2020	44Sc is an attractive positron-emitting radionuclide for PET imaging; herein, a new complex of the Sc3+ ion with nonmacrocyclic chelator H4pypa was synthesized and characterized with high-resolution electrospray-ionization mass spectrometry (HR-ESI-MS), as well as different nuclear magnetic resonance (NMR) spectroscopic techniques (1H, 13C, 1H-13C HSQC, 1H-13C HMBC, COSY, and NOESY).	Hydrogen	343-345	secretory carrier membrane protein 3	Mus musculus	99-102
9008359-1	1996	The three-dimensional structure of synthetic human neuropeptide Y in aqueous solution at pH 3.2 and 37 degrees C was determined from two-dimensional 1H NMR data recorded at 600 MHz.	Hydrogen	149-151	neuropeptide Y	Homo sapiens	51-65
16914729-5	2006	The dispensability of N(6) hydrogen bonding for proficient T incorporation opposite template A has important biological implications, as that would endow Pol iota with the ability to replicate through lesions which impair the Watson-Crick hydrogen bonding potential at both the N1 and N(6) positions of templating A.	Hydrogen	239-247	DNA polymerase mu	Homo sapiens	154-162
8976559-0	1996	Significant hydrogen exchange protection in GroEL-bound DHFR is maintained during iterative rounds of substrate cycling.	Hydrogen	12-20	dihydrofolate reductase	Homo sapiens	56-60
16873120-2	2006	An alternate model for tunnelling emerged following studies of the hydrogen atom transfer catalysed by the enzyme soybean lipoxygenase.	Hydrogen	67-75	linoleate 9S-lipoxygenase-4	Glycine max	122-134
16873121-1	2006	B12-dependent methylmalonyl-CoA mutase catalyses the interchange of a hydrogen atom and the carbonyl-CoA group on adjacent carbons of methylmalonyl-CoA to give the rearranged product, succinyl-CoA.	Hydrogen	70-78	methylmalonyl-CoA mutase	Homo sapiens	14-38
31834838-6	2020	Hydrogen/deuterium exchange coupled to mass spectrometry narrowed down the region of interaction to KCNQ1 residues 352-374 and KCNE1 residues 70-81, and provided evidence of secondary structure within these segments.	Hydrogen	0-8	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	127-132
30734268-3	2020	Here we have investigated whether and how exogenous H2 S alleviates cardiac muscle degradation through modifications of MuRF1 S-sulfhydration in db/db mice.	Hydrogen	52-54	tripartite motif-containing 63	Mus musculus	120-125
16819516-3	2006	The structural basis of this action is rotation of the epsilon dA adduct to the syn conformation in the Pol iota active site and presentation of its "Hoogsteen edge" for hydrogen-bonding with incoming dTTP or dCTP.	Hydrogen	170-178	DNA polymerase mu	Homo sapiens	104-112
30734268-12	2020	CONCLUSIONS AND IMPLICATIONS: Our findings suggest that H2 S regulates MuRF1 S-sulfhydration at Cys44 to prevent myocardial degradation in the cardiac tissues of db/db mice.	Hydrogen	56-58	tripartite motif-containing 63	Mus musculus	71-76
8976559-2	1996	Here we describe the conformational properties of human dihydrofolate reductase (DHFR) bound to GroEL at different stages of its ATP-driven folding reaction, determined by hydrogen exchange labeling and electrospray ionization mass spectrometry.	Hydrogen	172-180	dihydrofolate reductase	Homo sapiens	56-79
8976559-2	1996	Here we describe the conformational properties of human dihydrofolate reductase (DHFR) bound to GroEL at different stages of its ATP-driven folding reaction, determined by hydrogen exchange labeling and electrospray ionization mass spectrometry.	Hydrogen	172-180	dihydrofolate reductase	Homo sapiens	81-85
16581833-1	2006	According to the binding-zipper model, the RecA class of ATPase motors converts chemical energy into mechanical force by the progressive annealing of hydrogen bonds between the nucleotide and the catalytic pocket.	Hydrogen	150-158	RAD51 recombinase	Homo sapiens	43-47
8976559-3	1996	Considerable protection involving about 20 hydrogens is observed in DHFR bound to GroEL in the absence of ATP.	Hydrogen	43-52	dihydrofolate reductase	Homo sapiens	68-72
31525262-5	2020	The C-terminal Pro generates three interactions (hydrogen bonds, hydrophilic interactions and Van der Waals interactions) in the peptide and effectively interacts with the S1 and S2 pockets of ACE.	Hydrogen	49-57	angiotensin-converting enzyme	Oreochromis niloticus	193-196
16771319-3	2006	Solvent-derived adducts, DMPO/*OC2H5 and DMPO/*CH(OH)CH3, were identified, and their presence was rationalized by Fe(III)-catalyzed nucleophilic addition of ethanol to the spin trap and hydrogen abstraction by *OH radicals; oxygen radical adducts, DMPO/*O2(-) and DMPO/*OOH, were also detected.	Hydrogen	186-194	spindlin 1	Homo sapiens	172-176
8976559-5	1996	DHFR rebound to GroEL 3 min after initiating its folding by the addition of MgATP was also examined by hydrogen exchange, fluorescence quenching, and ANS binding.	Hydrogen	103-111	dihydrofolate reductase	Homo sapiens	0-4
8976564-0	1996	NMR studies of structure, hydrogen exchange, and main-chain dynamics in a disrupted-core mutant of thioredoxin.	Hydrogen	26-34	thioredoxin	Homo sapiens	99-110
16722755-4	2006	The B3LYP optimal position of H2 physisorbed at the acidic Bronsted sites of chabazite (Si/Al = 11/1 and 5/1) brings about an interaction energy definitely smaller than that derived from infrared spectroscopy, because of the known deficiencies of this functional to cope with dispersive interactions.	Hydrogen	30-32	ephrin A5	Homo sapiens	91-108
8942679-0	1996	Active site structure in cytochrome c peroxidase and myoglobin mutants: effects of altered hydrogen bonding to the proximal histidine.	Hydrogen	91-99	myoglobin	Homo sapiens	53-62
31808690-4	2020	A relatively strong interaction between the silanol groups and the ions of [DBU][MSA] and the ability of this PIL to form a thicker solvation layer through hydrogen bonding was assumed to be responsible for this unique behavior.	Hydrogen	156-164	serpin family A member 2 (gene/pseudogene)	Homo sapiens	110-113
8942679-8	1996	Here we use site-specific mutagenesis to eliminate the strong proximal hydrogen bonding in cytochrome c peroxidase and to introduce strong proximal hydrogen bonding in myoglobin.	Hydrogen	148-156	myoglobin	Homo sapiens	168-177
16488667-5	2006	Urocortin decreased the serum ACE level 1h after administration, whereas tissue ACE immunoreactivity and mRNA did not change.	Hydrogen	40-42	urocortin	Rattus norvegicus	0-9
8942679-9	1996	Consistent with our hypothesis, elimination of the Asp235-His175 hydrogen bond in CcP results in elongation of Fe-N epsilon from approximately 1.9 to approximately 2.1 A. Conversely, introduction of a similar strong proximal hydrogen bond in myoglobin shortens Fe-N epsilon from approximately 2.1 to approximately 1.9 A.	Hydrogen	65-73	myoglobin	Homo sapiens	242-251
16551744-4	2006	The predicted structures for apo-beta2AR and butoxamine-beta2AR are stable in MD, but in epinephrine-beta2AR, extracellular water trickles into the binding pocket to mediate hydrogen bonding between the catechol of epinephrine and Ser-204 on helix 5.	Hydrogen	174-182	adrenoceptor beta 2	Homo sapiens	33-40
31829547-3	2020	Herein, a hybrid artificial protective layer, constructed by one-step method through chemical reactions between Li metal and 1H,1H,1H,2H-Perfluorodecyltrimethoxysilane (FOS), is demonstrated to guide Li deposition and protect lithium batteries from the destruction of Li dendrites.	Hydrogen	128-167	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	169-172
8917642-5	1996	From the modeling analysis, we found that the carbonyl oxygen of the N-acetyl group of GlcNAc in 3 formed a hydrogen bond with the amide group of Asn 82 in P-selectin.	Hydrogen	108-116	selectin P	Homo sapiens	156-166
16539432-0	2006	Heats of transfer in the diffusion layer before the surface and the surface temperature for a catalytic hydrogen oxidation (H2 + (1/2)O2 --&gt; H2O) reaction.	Hydrogen	104-112	immunoglobulin kappa variable 1D-39	Homo sapiens	129-136
16539432-0	2006	Heats of transfer in the diffusion layer before the surface and the surface temperature for a catalytic hydrogen oxidation (H2 + (1/2)O2 --&gt; H2O) reaction.	Hydrogen	124-126	immunoglobulin kappa variable 1D-39	Homo sapiens	129-136
8891161-2	1996	A novel hydrogen bond between the hydroxyl of Thr-182 and the carbonyl of Glu-64 was expected to be responsible for the increase in the catalytic activity of the IST-T182 and IRT-3 enzymes compared with those of TEM-1 and IRT-169, respectively.	Hydrogen	8-16	CD248 molecule	Homo sapiens	212-217
16315141-1	2006	The preferred conformation of Proadrenomedullin N-Terminal 20 Peptide (PAMP; ARLDVASEFRKKWNKWALSR-amide) has been determined using 1H and 13C two-dimensional nuclear magnetic resonance (NMR) spectroscopy and molecular modeling.	Hydrogen	131-133	adrenomedullin	Homo sapiens	30-69
16315141-1	2006	The preferred conformation of Proadrenomedullin N-Terminal 20 Peptide (PAMP; ARLDVASEFRKKWNKWALSR-amide) has been determined using 1H and 13C two-dimensional nuclear magnetic resonance (NMR) spectroscopy and molecular modeling.	Hydrogen	131-133	adrenomedullin	Homo sapiens	71-75
32832488-6	2020	Molecular docking results showed that the highest binding affinity to uric acid belonged to uricase-PAS1-100 by the formation of six hydrogen and four non-hydrogen bonds.	Hydrogen	133-141	urate oxidase (pseudogene)	Homo sapiens	92-99
32832488-6	2020	Molecular docking results showed that the highest binding affinity to uric acid belonged to uricase-PAS1-100 by the formation of six hydrogen and four non-hydrogen bonds.	Hydrogen	155-163	urate oxidase (pseudogene)	Homo sapiens	92-99
31146672-10	2020	The molecular docking study proposed good activity as a MDM-2 inhibitor suggesting hydrophobic as well as hydrogen bonding interactions with MDM2.	Hydrogen	106-114	MDM2 proto-oncogene	Homo sapiens	56-61
31146672-10	2020	The molecular docking study proposed good activity as a MDM-2 inhibitor suggesting hydrophobic as well as hydrogen bonding interactions with MDM2.	Hydrogen	106-114	MDM2 proto-oncogene	Homo sapiens	141-145
16494969-6	2006	Docking of 2-[[-5-bromo-2-oxoindolin-3-ylidene]amino]-3-(1H-imidazol2-yl)propanoic acid 14 to CDK5/p25 indicates that this compound can interact with the enzyme through four hydrogen bonds; for GSK/3beta, the ligand poses itself in another orientation, also four hydrogen bonds can be formed between the ligand and the receptor, otherwise hydrophobic interactions seem to predominate.	Hydrogen	174-182	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	99-102
8931948-0	1996	Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations.	Hydrogen	103-105	thymidylate synthetase	Homo sapiens	59-79
16494969-6	2006	Docking of 2-[[-5-bromo-2-oxoindolin-3-ylidene]amino]-3-(1H-imidazol2-yl)propanoic acid 14 to CDK5/p25 indicates that this compound can interact with the enzyme through four hydrogen bonds; for GSK/3beta, the ligand poses itself in another orientation, also four hydrogen bonds can be formed between the ligand and the receptor, otherwise hydrophobic interactions seem to predominate.	Hydrogen	263-271	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	99-102
16492043-2	2006	Stereoselective synthesis of octahydro-5,6,6a-triazaacenaphthalenes 29 and 34 having the anti-relationship of the angular hydrogens flanking the pyrrolidine nitrogen confirmed suspicions that the relative configuration of the left-hand tricyclic guanidine fragment of batzelladine F should be revised to have the syn relationship of these hydrogens.	Hydrogen	122-131	synemin	Homo sapiens	16-19
31807868-4	2020	Molecular docking of 4H derivative showed more favorable thermodynamic parameters against thymidylate synthase of B. malayi than human counterpart.	Hydrogen	21-23	Uncharacterized protein	Brugia malayi	90-110
33731981-4	2020	1H NMR titrations show that P1 and P2 are poor hosts toward hydrophobic (di)cations 6 - 11 (P1: Ka = 375-1400 M-1; P2: Ka = 1950-19800 M-1) compared to Tet1 and Tet2 (Tet1: Ka = 3.09 x 106 to 4.69 x 108 M-1; Tet2: Ka = 4.59 x 108 to 1.30 x 1010 M-1).	Hydrogen	0-2	crystallin gamma F, pseudogene	Homo sapiens	28-37
16492043-2	2006	Stereoselective synthesis of octahydro-5,6,6a-triazaacenaphthalenes 29 and 34 having the anti-relationship of the angular hydrogens flanking the pyrrolidine nitrogen confirmed suspicions that the relative configuration of the left-hand tricyclic guanidine fragment of batzelladine F should be revised to have the syn relationship of these hydrogens.	Hydrogen	339-348	synemin	Homo sapiens	16-19
8931948-1	1996	The conformations of a set of phthalein derivatives with bacterial thymidylate synthase (TS) inhibitory activity were investigated by 1H NMR spectra, performed at both room and low temperature, and by quantum chemical calculations.	Hydrogen	134-136	thymidylate synthetase	Homo sapiens	89-91
8810926-0	1996	High frequency (139.5 GHz) electron paramagnetic resonance characterization of Mn(II)-H2(17)O interactions in GDP and GTP forms of p21 ras.	Hydrogen	86-88	H3 histone pseudogene 16	Homo sapiens	131-134
16424903-7	2006	The only residue unambiguously distinguishing the FT and TFL1 loops makes a hydrogen bond with a residue near the entrance of a potential ligand-binding pocket in TFL1, but not in FT.	Hydrogen	76-84	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	57-61
31956791-5	2020	In this report, we show that a simple modification of relatively less common weak interactions, such as C-H   pi(Ar)   pi(C N)   pi(Ar), through the preparation of isomers, can lead to a drastic change in crystal packing (HP   BP).	Hydrogen	104-107	HPBP	Homo sapiens	222-229
8794736-9	1996	The guanido group (N eta 1, N eta 2) of Arg61 in the complex interacts with S delta of Met25i(P1") by possible hydrogen bonds between N and S atoms, accompanying a large positional shift of the side chain of Arg61-(S1") between the complexed and free forms of PPE.	Hydrogen	111-119	secreted phosphoprotein 1	Homo sapiens	21-35
31733293-2	2019	Here, the amphiphilic gemcitabine-oleic acid prodrugs (GOA) binding miRNAs with hydrogen bond are assembled into nanoparticles (GOA/miR NPs) through hydrophobic interaction via denaturation-annealing processes and nano-precipitation technique.	Hydrogen	80-88	membrane associated ring-CH-type finger 8	Homo sapiens	68-71
31733293-8	2019	The non-cationic GOA/miR NPs engineered by hydrogen bond interaction and hydrophobic forces show the enhanced synergistic antitumor efficacy and good biosafety, which will provide a potential nanomedcine for HCC treatment.	Hydrogen	43-51	membrane associated ring-CH-type finger 8	Homo sapiens	21-24
16424903-7	2006	The only residue unambiguously distinguishing the FT and TFL1 loops makes a hydrogen bond with a residue near the entrance of a potential ligand-binding pocket in TFL1, but not in FT.	Hydrogen	76-84	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	163-167
16435874-0	2006	Hydrogen-mediated aldol reductive coupling of vinyl ketones catalyzed by rhodium: high syn-selectivity through the effect of tri-2-furylphosphine.	Hydrogen	0-8	synemin	Homo sapiens	87-90
16922595-0	2006	In-silico pharmacodynamics: correlation of adverse effects of H2-antihistamines with histamine N-methyl transferase binding potential.	Hydrogen	62-64	histamine N-methyltransferase	Homo sapiens	85-115
8794736-10	1996	The primary binding site is stabilized by hydrogen bonds between the guanido group (N eta 1, N eta 2) of Arg22i(P3) and the carbonyl group of Met25i(P1") across the scissile bond, as well as by a hydrogen bond between the amino group of Cys23i(P2) and the carbonyl group of Ser48i in the internal core.	Hydrogen	42-50	secreted phosphoprotein 1	Homo sapiens	86-100
8794736-10	1996	The primary binding site is stabilized by hydrogen bonds between the guanido group (N eta 1, N eta 2) of Arg22i(P3) and the carbonyl group of Met25i(P1") across the scissile bond, as well as by a hydrogen bond between the amino group of Cys23i(P2) and the carbonyl group of Ser48i in the internal core.	Hydrogen	196-204	secreted phosphoprotein 1	Homo sapiens	86-100
16635554-2	2006	To achieve precise immunostaining within 1h, we attempted to generate a novel procedure, "freshly prepared immune complex with intermittent microwave irradiation (f-IC-M)".	Hydrogen	41-43	C-C motif chemokine ligand 7	Homo sapiens	163-167
8703940-9	1996	However, this results in less favorable binding of Arg-P1 in the oxyanion hole as shown by long hydrogen-bonding distances.	Hydrogen	96-104	diacylglycerol O-acyltransferase 1	Homo sapiens	51-57
16239221-3	2005	Using a metabolomics approach based on high resolution 1H NMR spectroscopy of the cortex, cerebellum, and remaining regions of the brain in conjunction with statistical pattern recognition, we report metabolic deficits associated with juvenile NCL in a Cln3 knock-out mouse model.	Hydrogen	55-57	nucleolin	Mus musculus	244-247
21132078-0	2005	Modeling temperature dependent kinetic isotope effects for hydrogen transfer in a series of soybean lipoxygenase mutants: The effect of anharmonicity upon transfer distance.	Hydrogen	59-67	linoleate 9S-lipoxygenase-4	Glycine max	100-112
31843910-6	2019	Using a mouse model of MHC I-dependent (H-2Dk) virus immunity, we discovered that NK cells depend on the Ly49G2 inhibitory self-receptor to mediate virus control, which coincided with host survival during murine cytomegalovirus infection.	Hydrogen	40-45	major histocompatibility complex, class I, C	Homo sapiens	23-26
31640987-9	2019	Employing hydrogen-deuterium exchange MS, we identified an MA-MA interface in the MA trimer that is implicated in Gag assembly and Env incorporation.	Hydrogen	10-18	endogenous retrovirus group K member 20	Homo sapiens	131-134
8805557-4	1996	Surprisingly, thioredoxin is dimeric in all four structures; the dimer is linked through a disulfide bond between Cys73 of each monomer, except in Cys73--&gt;Ser where a hydrogen bond occurs.	Hydrogen	170-178	thioredoxin	Homo sapiens	14-25
31718930-0	2019	Hydrogen ameliorates lung injury in a rat model of subacute exposure to concentrated ambient PM2.5 via Aryl hydrocarbon receptor.	Hydrogen	0-8	aryl hydrocarbon receptor	Rattus norvegicus	103-128
31718930-10	2019	In addition, low expression of AhR in lung tissues determined by Western Blot was found after CAPs exposure, whereas hydrogen inhibited AhR decline induced by CAPs.	Hydrogen	117-125	aryl hydrocarbon receptor	Rattus norvegicus	136-139
31718930-12	2019	Additionally, hydrogen alleviates lung injury induced by PM2.5 possibly through AhR-dependent mechanisms.	Hydrogen	14-22	aryl hydrocarbon receptor	Rattus norvegicus	80-83
16260760-0	2005	Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange.	Hydrogen	117-125	A-kinase anchoring protein 1	Homo sapiens	33-37
16260760-3	2005	Hydrogen/deuterium (H/D) exchange combined with mass spectrometry (DXMS) was used to probe backbone structural changes of an alpha-helical A-kinase binding (AKB) motif from D-AKAP2 docked to both RIalpha and RIIalpha D/D domains.	Hydrogen	0-8	A-kinase anchoring protein 10	Homo sapiens	173-180
31768722-8	2019	Hydrogen-rich water increased the activation of the Nrf2/ARE signaling pathway, and the levels of mRNA and protein Nrf2, NQO1, HO-1 and SOD-1 were significantly increased (P &lt; 0.05) in the ischemia-reperfusion period compared with the ischemic period.	Hydrogen	0-8	heme oxygenase 1	Rattus norvegicus	127-131
16277531-1	2005	Improved 1H ENDOR data from the S(EPR1) intermediate formed during turnover of the nitrogenase alpha-195Gln MoFe protein with C2(1,2)H2 in (1,2)H2O buffers, taken in context with the recent study of the intermediate formed from propargyl alcohol, indicate that S(EPR1) is a product complex, likely with C2H4 bound as a ferracycle to a single Fe of the FeMo-cofactor active site.	Hydrogen	9-11	baculoviral IAP repeat containing 5	Homo sapiens	34-38
8862555-2	1996	For example, hydrogen bonds are formed between H35/H95, L50/H97, H53/H55 and H96/L96 respectively.	Hydrogen	13-21	H3.5 histone	Homo sapiens	47-50
16262427-3	2005	In the absence of external hydrogen-bond donors and acceptors HBO exists as the internally hydrogen-bonded syn-enol, a mimic of the rare base pair tautomer found in DNA, which may be photoinduced to tautomerize and form the keto tautomer, a mimic of the dominant base pair tautomer.	Hydrogen	27-35	synemin	Homo sapiens	107-110
16262427-3	2005	In the absence of external hydrogen-bond donors and acceptors HBO exists as the internally hydrogen-bonded syn-enol, a mimic of the rare base pair tautomer found in DNA, which may be photoinduced to tautomerize and form the keto tautomer, a mimic of the dominant base pair tautomer.	Hydrogen	91-99	synemin	Homo sapiens	107-110
16262427-4	2005	Previously, we demonstrated that when incorporated into DNA such that the enol moiety is positioned in the major groove, HBO is not solvated, exists exclusively as the internally hydrogen-bonded syn-enol which is efficiently photoinduced to tautomerize, and the corresponding keto tautomer is preferentially stabilized.	Hydrogen	179-187	synemin	Homo sapiens	195-198
31448872-4	2019	METHODS: Hydrogen-deuterium exchange mass spectrometry is employed to test this hypothesis using G233V, M239V, G233V/M239V, W230L, and D235Y disease variants of GPIbalpha.	Hydrogen	9-17	glycoprotein Ib platelet subunit alpha	Homo sapiens	161-170
31448872-7	2019	Hydrogen-exchange is corroborated by differential scanning calorimetry, which confirms that these mutations destabilize GPIbalpha by allowing the beta-switch to dissociate from the leucine-rich-repeat (LRR) domain.	Hydrogen	0-8	glycoprotein Ib platelet subunit alpha	Homo sapiens	120-129
31448872-8	2019	The stability of GPIbalpha and its A1 binding affinity, determined by surface plasmon resonance, are correlated to the extent of hydrogen exchange in the beta-switch.	Hydrogen	129-137	glycoprotein Ib platelet subunit alpha	Homo sapiens	17-26
8928889-4	1996	After an acute myocardial infarction, we observed an initial rapid (1h) rise in VEGF (275%), flk-1 (375%), and flt-1 (400%) mRNA expression throughout the entire heart.	Hydrogen	68-70	vascular endothelial growth factor A	Rattus norvegicus	80-84
31246713-6	2019	Specifically, IL-1beta significantly increased from pre- to 5 min after both trials (23%, p&lt;0.05), IL-6 increased 1h following both trials (39%, p&lt;0.05), IL-10 was elevated 5 min after running (20%, p&lt;0.05) and 1h after both running and cycling (41% and 64%, respectively, p&lt;0.05), and TNF-alpha increased 5 min after running (10%, p&lt;0.05).	Hydrogen	220-222	interleukin 10	Homo sapiens	160-165
31509706-9	2019	We present results of MR-ADC(2) for photoelectron spectra of small molecules, carbon dimer, and equally-spaced hydrogen chains (H10 and H30) and outline directions for future developments.	Hydrogen	111-119	H1.0 linker histone	Homo sapiens	128-131
15978629-6	2005	c-fos expression was used as a marker of neuronal activation and revealed by immunohistochemistry 1h after intraperitoneal acetic acid injection and 2 h after colonic inflammation.	Hydrogen	98-100	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
8928889-4	1996	After an acute myocardial infarction, we observed an initial rapid (1h) rise in VEGF (275%), flk-1 (375%), and flt-1 (400%) mRNA expression throughout the entire heart.	Hydrogen	68-70	kinase insert domain receptor	Rattus norvegicus	93-98
16224104-4	2005	In the lambda-repressor-DNA complex, the epsilon-NH(2) group (hydrogen bond donor) of lysine-4 of lambda-repressor forms hydrogen bonds with the amide carbonyl atom of asparagine-55 (acceptor) and the O6 (acceptor) of CG6 of operator site O(L)1.	Hydrogen	62-70	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	201-244
16224104-4	2005	In the lambda-repressor-DNA complex, the epsilon-NH(2) group (hydrogen bond donor) of lysine-4 of lambda-repressor forms hydrogen bonds with the amide carbonyl atom of asparagine-55 (acceptor) and the O6 (acceptor) of CG6 of operator site O(L)1.	Hydrogen	121-129	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	201-244
8807854-4	1996	Energy minimizations of Gb3 within the "cleft site" of verotoxins VT1, VT2, VT2c and VT2e resulted in stable complexes with hydrogen-bonding systems that were in agreement with binding data obtained for mono-deoxy analogues of Gb3.	Hydrogen	124-132	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	24-27
16204884-7	2005	Furthermore, we identify a conserved C-H...pi hydrogen bond between two key residues in the consensus Kelch repeat.	Hydrogen	46-54	kelch like family member 2	Homo sapiens	102-107
11725090-5	1996	The antagonist-binding pocket of the human 5-HT(1A)R is inferred from the interaction sites of pindolol with the receptor model: (1) the ionic interaction between the protonated amine of the ligand and the side chain of the conserved Asp-116, located in TMH 3; and (2) the hydrogen bonds between the ether oxygen and the hydroxyl group of the ligand and Asn-385, located in TMH 7.	Hydrogen	273-281	5-hydroxytryptamine receptor 1A	Homo sapiens	43-50
16009714-9	2005	However, the viral protein makes a unique contact: a hydrogen bond network formed between Asp210 in LMP1 and Tyr395 and Arg393 in TRAF3.	Hydrogen	53-61	PDZ and LIM domain 7	Homo sapiens	100-104
16009714-9	2005	However, the viral protein makes a unique contact: a hydrogen bond network formed between Asp210 in LMP1 and Tyr395 and Arg393 in TRAF3.	Hydrogen	53-61	TNF receptor associated factor 3	Homo sapiens	130-135
16009714-11	2005	The additional hydrogen bonds may stabilize the complex and strengthen the binding to permit LMP1 to compete with CD40 for binding to the TRAF3 crevice, influencing downstream signaling to B lymphocytes and contributing to dysregulated signaling by LMP1.	Hydrogen	15-23	PDZ and LIM domain 7	Homo sapiens	93-97
16009714-11	2005	The additional hydrogen bonds may stabilize the complex and strengthen the binding to permit LMP1 to compete with CD40 for binding to the TRAF3 crevice, influencing downstream signaling to B lymphocytes and contributing to dysregulated signaling by LMP1.	Hydrogen	15-23	TNF receptor associated factor 3	Homo sapiens	138-143
31580070-1	2019	The rate-limiting chemical reaction catalyzed by soybean lipoxygenase (SLO) involves quantum mechanical tunneling of a hydrogen atom from substrate to its active site ferric-hydroxide cofactor.	Hydrogen	119-127	linoleate 9S-lipoxygenase-4	Glycine max	57-69
31532627-3	2019	Such this biosensor displays an outstanding fluores-cence/macroscopic response for Tyr and reversible fluidic features due to the hydrogen interaction between the PCAD of CdSe-LQDs and Tyr.	Hydrogen	130-138	cadherin 3	Homo sapiens	163-167
16009714-11	2005	The additional hydrogen bonds may stabilize the complex and strengthen the binding to permit LMP1 to compete with CD40 for binding to the TRAF3 crevice, influencing downstream signaling to B lymphocytes and contributing to dysregulated signaling by LMP1.	Hydrogen	15-23	PDZ and LIM domain 7	Homo sapiens	249-253
8652630-2	1996	We have identified two 1H-NMR markers diagnostic of metal ion binding to the high-affinity Ca2+-binding site of bovine alpha-lactalbumin, namely the signals corresponding to the delta-CH3 groups of Met-90, and a leucine, tentatively assigned to Leu-96.	Hydrogen	23-25	lactalbumin alpha	Bos taurus	119-136
31282022-7	2019	At last, the TPA lid used its central methylene hydrogens to establish, within the M-1(-) CX4 , three stabilizing C-H   X-C interactions with the guest.	Hydrogen	48-57	cholinergic receptor muscarinic 1	Homo sapiens	83-93
8652634-1	1996	1H-NMR spectroscopy was applied to a study of the mode of interaction, in aqueous medium in the pH range 5.2-8.5 and at low and high temperatures, between several mono- and dinucleotide analogues of the mRNA cap m7GpppG and a selected tripeptide Trp-Leu-Glu, and a tetrapeptide Trp-Glu-Asp-Glu, the sequence of which corresponds to one of the suspected binding sites in the mRNA cap-binding protein (CBP).	Hydrogen	0-2	eukaryotic translation initiation factor 4E	Mus musculus	374-398
8737057-1	1996	MX1 (N-[3-(3-(1-piperidinylmethyl)phenoxy)propyl]-hydroxyacetamide+ ++ 2-hydroxypropane-1,2,3-tricarboxylate bismuth (3+) complex) is a novel salt of the active metabolite of H2-antagonist roxatidine with a complex of bismuth with citric acid.	Hydrogen	175-177	MX dynamin like GTPase 1	Rattus norvegicus	0-3
31268193-4	2019	This finding is quite unexpected because the initial spin density at the terminal carbon atom of FeC4 + , which serves as the hydrogen acceptor site, is low.	Hydrogen	126-134	spindlin 1	Homo sapiens	53-57
31066963-5	2019	For the disaccharide beta-d-GlcpNAc-(1 2)-beta-d-Manp-OMe, the large extent of O5"   HO3 hydrogen bonding as seen from the MD simulation is implicitly supported by the 1 H NMR chemical shift and 3 JHO3,H3 value of the hydroxy proton.	Hydrogen	89-97	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	85-88
31066963-6	2019	In the case of alpha-d-Glcp-(1 4)-beta-d-Glcp-OMe, the existence of a transglycosidic hydrogen bond O2"   HO3 was proven by the presence of a cross-peak in 1 H,13 C HSQC-TOCSY experiments as a result of direct TOCSY transfer between HO3 of the reducing end residue and H2" (detected at C2") of the terminal residue.	Hydrogen	86-94	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	106-109
16201664-4	2005	Because the rate of hydrogen entering the iron lattice increases with PH2(1/2), and the rate of hydrogen production from corrosion, far from equilibrium conditions, is independent of PH2, at some time under closed system conditions the two rates become equal and a steady-state PH2 is attained.	Hydrogen	20-28	polyhomeotic homolog 2	Homo sapiens	70-73
16212421-7	2005	However, it has also been observed via a close view that some residues of the TXA2 receptor that are sequentially far away but spatially quite close to the loop region are also involved in forming hydrogen bonds with the minigene of G alpha 13.	Hydrogen	197-205	G protein subunit alpha 13	Homo sapiens	233-243
31066963-6	2019	In the case of alpha-d-Glcp-(1 4)-beta-d-Glcp-OMe, the existence of a transglycosidic hydrogen bond O2"   HO3 was proven by the presence of a cross-peak in 1 H,13 C HSQC-TOCSY experiments as a result of direct TOCSY transfer between HO3 of the reducing end residue and H2" (detected at C2") of the terminal residue.	Hydrogen	86-94	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	233-236
16101277-5	2005	Several hydrogen bonds and salt bridges that stabilize the BRCA1-BACH1 complex are missing in the BRCA1-CtIP interaction, offering a structural basis for the approximately 5-fold lower affinity of BRCA1 for CtIP compared to that of BACH1, as determined by isothermal titration calorimetry.	Hydrogen	8-16	BRCA1 DNA repair associated	Homo sapiens	59-64
8742240-6	1996	The substrate specificity has been rationalized in terms of a hydrogen bond donor/acceptor model and, by use of molecular modeling, an active site template model for CYP2C9 has been generated.	Hydrogen	62-70	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	166-172
16076184-2	2005	Catalyst design, based on new Ru(II) hydrido carbonyl complexes incorporating electron-rich PNP and PNN ligands has resulted in the novel complex (I) which is an outstanding catalyst for the dehydrogenation of primary alcohols to esters and H(2) under neutral conditions.	Hydrogen	241-245	pinin, desmosome associated protein	Homo sapiens	100-103
9981925-0	1996	Total-energy study of hydrogen ordering in PdHx (0 &lt;~ x &lt;~ 1).	Hydrogen	22-30	pyruvate dehydrogenase complex component X	Homo sapiens	43-47
16024694-11	2005	Absolute expression levels for GAPDH and 29a were lowly heritable (h2 of about 0.04), although estimates did not exceed their SE.	Hydrogen	67-69	glyceraldehyde-3-phosphate dehydrogenase	Sus scrofa	31-36
31252023-3	2019	In silico docking simulations predicted anti-tumor molecular mechanism and protein-piperine hydrophobic interactions, showing hydrogen bonds between piperine and residue Ser5 inside the ATP binding site in CDK2.	Hydrogen	126-134	cyclin-dependent kinase 2	Mus musculus	206-210
7578145-0	1995	Assessment of stability differences in the protein G B1 and B2 domains from hydrogen-deuterium exchange: comparison with calorimetric data.	Hydrogen	76-84	membrane spanning 4-domains A1	Homo sapiens	53-62
31569521-2	2019	Its lipid inhibition effects indicated that the synthetic peptide PP1 exhibits a good inhibitory effect against porcine pancreatic lipase (PL) (47.95%) at 200 mug/mL, which could be attributed to its hydrogen binding into catalytic sites of PL (Ser153, Asp177, and His 264) by docking analysis.	Hydrogen	200-208	pancreatic lipase	Mus musculus	120-137
31569643-8	2019	Two hydrogen bonds between syn-ClG and anti-dGTP and a water-mediated hydrogen bond appeared to facilitate mutagenic replication opposite the major halogenated guanine lesion.	Hydrogen	4-12	synemin	Homo sapiens	27-30
16014707-5	2005	Additionally, mutational studies with Leu-62, which lies in close proximity to the templating residue in the Pol iota ternary complex, have indicated that both factors, steric constraints within the active site and the stability provided by the hydrogen bonds in the Hoogsteen base pair, contribute to the efficiency of correct nucleotide incorporation opposite template purines by Pol iota.	Hydrogen	245-253	DNA polymerase mu	Homo sapiens	109-117
15925139-3	2005	We examined the integrity of this brain region using proton magnetic resonance spectroscopy (1H MRS) and hypothesised that functional changes measured by 1H MRS would be associated with cognitive performance.	Hydrogen	154-156	MROS	Homo sapiens	157-160
7578145-1	1995	Hydrogen-deuterium (H-D) exchange experiments have been used to measure exchange rates for almost all of the main-chain amide protons (NHs) in the B1 and B2 IgG-binding domains of protein G. For H-bonded NHs, exchange rates were also measured as a function of temperature from 25 to 65 degrees C for B1 and from 25 to 60 degrees C for B2.	Hydrogen	0-8	membrane spanning 4-domains A1	Homo sapiens	147-156
8567187-0	1995	Solution structure of the B-chain of insulin as determined by 1H NMR spectroscopy.	Hydrogen	62-64	insulin	Bos taurus	37-44
16189564-8	2005	The largest chirodiastaltic energy is found at 0.74 kcal mol(-1) for the (syn)trans-propylene imine.hydrogen peroxide complexes, where hydrogen peroxide acts as a hydrogen donor and is on the opposite side of the ring from the methyl group.	Hydrogen	100-108	synemin	Homo sapiens	74-77
16212054-7	2005	The excitation frequencies of spin-diffusion spectra were shifted far away from typical 1H NMR spectra of carbonic anhydrase B.	Hydrogen	88-90	spindlin 1	Homo sapiens	30-34
31483657-0	2019	Spin-Polarized Hydrogen Depolarization Rates at High Hydrogen Halide Pressures: Hyperfine Depolarization via the HY-H Complex.	Hydrogen	15-23	spindlin 1	Homo sapiens	0-4
31483657-1	2019	We measure the magnetization quantum beats of spin-polarized hydrogen (SPH) and spin-polarized deuterium (SPD) with a pickup coil, from the UV photodissociation of HCl, HBr, and DI, in the 5-5000 mbar pressure range.	Hydrogen	61-69	spindlin 1	Homo sapiens	46-50
31318987-4	2019	DFT studies of the potential energy surface (B3LYP/6-31+G(d)+CPCM (dichloromethane)) of the reaction correlate the activity of different catalysts and support an intramolecular hydrogen-bond-assisted activation of the squaramide moiety in the transition state of the catalytic reaction.	Hydrogen	177-185	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	47-50
16212054-7	2005	The excitation frequencies of spin-diffusion spectra were shifted far away from typical 1H NMR spectra of carbonic anhydrase B.	Hydrogen	88-90	carbonic anhydrase 2	Homo sapiens	106-126
8567187-2	1995	The solution structure of the isolated B-chain of bovine insulin has been determined by 1H NMR spectroscopy combined with simulated annealing calculations.	Hydrogen	88-90	insulin	Bos taurus	57-64
7473721-2	1995	For example, an alanine residue at H71 provides room for packing CDR2/CDR1 and lysine residues at H73 and H93 contribute a salt-bridge to aspartic acid at H55 in CDR2 and a hydrogen bond to the carbonyl group at H96 in CDR3, respectively.	Hydrogen	173-181	cerebellar degeneration related protein 1	Homo sapiens	70-74
31418568-3	2019	The benzene-Cl2/Br2 binding energies (13.07 +- 0.42/16.62 +- 0.02 kJ/mol) attributed to both halogen bonding and dispersion are smaller than but comparable to the typical hydrogen bonding in the water dimer binding energy (20.88 +- 0.27 kJ/mol).	Hydrogen	171-179	endogenous retrovirus group W member 5	Homo sapiens	12-15
7662871-0	1995	Changes in structure of the chromophore in the photochemical process of bovine rhodopsin as revealed by FTIR spectroscopy for hydrogen out-of-plane vibrations.	Hydrogen	126-134	rhodopsin	Bos taurus	79-88
31407917-6	2019	The redox species generated by the photosensitizer-aptamer/electron acceptor supramolecular systems mediate the ferredoxin-NADP+ reductase, FNR, catalyzed synthesis of NADPH, and the Pt-nanoparticle-catalyzed evolution of hydrogen (H2).	Hydrogen	222-230	2,4-dienoyl-CoA reductase 1	Homo sapiens	168-173
15922841-3	2005	The SAR revealed that the triterpenes possessing two hydrogen-bond forming groups (an H-donor and a carbonyl group) at positions 3 and 28 exhibit cytotoxic activity.	Hydrogen	53-61	sarcosine dehydrogenase	Homo sapiens	4-7
15913341-1	2005	Infrared, X-ray structural, 1H NMR, and computational evidence for pi-solvation of H3O+ by benzene molecules is presented.	Hydrogen	28-30	H3 clustered histone 15	Homo sapiens	83-86
7556201-1	1995	1H-NMR and circular dichroism studies have been carried out on osteocalcin, a 49-residue, calcium-binding protein, the sequence of which contains a disulphide bridge, a proline-rich segment and three gamma-carboxyglutamic acid (Gla) residues.	Hydrogen	0-2	bone gamma-carboxyglutamate protein	Bos taurus	63-74
15895986-8	2005	On the other hand, the S-H group of the reactive cysteine forms a hydrogen bond in phy3-LOV1, which is strengthened at low temperatures.	Hydrogen	66-74	NAC domain containing protein 35	Arabidopsis thaliana	88-92
31226370-5	2019	FTIR proved the presence of functional groups and strong hydrogen bonding between the molecules of CNF/PVA and the efficient crosslinking.	Hydrogen	57-65	NPHS1 adhesion molecule, nephrin	Homo sapiens	99-102
7540989-1	1995	The separations between aromatic residues in the bait region and nitroxide spin labels attached to the thiol ester-forming residues (Cys949 and Gln952) in human alpha 2-macroglobulin (alpha 2M) have been determined from paramagnetic broadening effects of the spin labels on bait region 1H NMR signals.	Hydrogen	286-288	alpha-2-macroglobulin	Homo sapiens	161-182
30204055-9	2019	The hydrogen bonding of compounds with Asp1198, His1201, Tyr1203 in TNKS1 and Gly1032, Ser1068 in TNKS2 are the key interactions plays a major role in binding energy.	Hydrogen	4-12	tankyrase 2	Homo sapiens	98-103
16852085-11	2005	A hydrogen bond is frequently formed between the 5"-OH group and the syn bases, despite competition by water.	Hydrogen	2-10	synemin	Homo sapiens	69-72
15805646-1	2005	The title compound, C25H30NO2+.Cl-, has been synthesized, and the crystal structure shows that it is mainly stabilized through intermolecular N-H...Cl and O-H...Cl and intramolecular N-H...O hydrogen bonds.	Hydrogen	191-199	cholesterol 25-hydroxylase	Homo sapiens	20-24
7540989-1	1995	The separations between aromatic residues in the bait region and nitroxide spin labels attached to the thiol ester-forming residues (Cys949 and Gln952) in human alpha 2-macroglobulin (alpha 2M) have been determined from paramagnetic broadening effects of the spin labels on bait region 1H NMR signals.	Hydrogen	286-288	alpha-2-macroglobulin	Homo sapiens	184-192
16097692-6	2005	When pH&gt;4, the fluorescence emission peak at 499 nm gradually blue-shifted to 455 nm as pH was increasing, and an iso-fluorescence emission point was formed at 484 nm, indicating the dissociation of hydrogen ion of carboxylic acid at C-3.	Hydrogen	202-210	complement C3	Homo sapiens	237-240
7647555-1	1995	The relaxation rates of the multiple-quantum coherence for the amide hydrogen of Gly13 in ras p21.GDP were determined in the presence and absence of 17O labeling in the beta-phosphate of GDP.	Hydrogen	69-77	H3 histone pseudogene 16	Homo sapiens	94-97
15716405-9	2005	These results demonstrate that 1H MRSI can evaluate dopaminergic degeneration and its protection by Cop-1 immunization strategies.	Hydrogen	31-33	COP1, E3 ubiquitin ligase	Mus musculus	100-105
31444342-5	2019	Using hydrogen-deuterium exchange (HDX)-MS we show that CRL2 activates CSN5/CSN6 in a neddylation-independent manner.	Hydrogen	6-14	DAN domain BMP antagonist family member 5	Homo sapiens	56-60
7676464-9	1995	The findings show that substitutions on the carbon 6 position of STX have stronger effects on STX potency than previously believed, and that the toxin may form a hydrogen bond with the sodium channel at this site.	Hydrogen	162-170	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	65-68
31324450-8	2019	These results suggest that after guide RNA-driven conformational changes, water-mediated hydrogen-bonding networks tie together the converged domains to complete the functional RISC structure.	Hydrogen	89-97	serine carboxypeptidase 1	Homo sapiens	177-181
31420591-5	2019	Furthermore, hydrogen/deuterium exchange mass spectrometric analysis reveals that the Fab portion of IgG1 is directly involved in its interaction with FcgammaRIIIa, in addition to the canonical Fc-mediated interaction.	Hydrogen	13-21	Fc gamma receptor IIIa	Homo sapiens	151-163
15681865-3	2005	The conformation of mDHFR Arg22 is such that it makes hydrogen-bonding contacts with Asp21, Trp24 and a structural water molecule, observations which were not made in the L22R hDHFR ternary complex.	Hydrogen	54-62	dihydrofolate reductase	Mus musculus	20-25
15681865-3	2005	The conformation of mDHFR Arg22 is such that it makes hydrogen-bonding contacts with Asp21, Trp24 and a structural water molecule, observations which were not made in the L22R hDHFR ternary complex.	Hydrogen	54-62	beta-secretase 2	Homo sapiens	85-90
31440160-13	2019	Furthermore, pretreatment with hydrogen resulted in cardioprotection during septic cardiomyopathy via inhibiting the expression of pro-inflammatory cytokines TNFalpha, IL-1beta, and IL-18; suppressing the phosphorylation of ERK1/2, p38, and JNK; and reducing the nuclear translocation of NF-kappaB and the expression of TLR4 by LPS.	Hydrogen	31-39	mitogen-activated protein kinase 8	Mus musculus	241-244
7756285-0	1995	1H, 13C, and 15N NMR resonance assignments, secondary structure, and backbone topology of a variant of human interleukin-3.	Hydrogen	0-2	interleukin 3	Homo sapiens	109-122
31089833-3	2019	Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus.	Hydrogen	0-8	receptor-interacting serine-threonine kinase 3	Rattus norvegicus	120-125
15692743-0	2005	Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2).	Hydrogen	9-11	splA/ryanodine receptor domain and SOCS box containing 2	Homo sapiens	51-92
15692743-0	2005	Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2).	Hydrogen	9-11	splA/ryanodine receptor domain and SOCS box containing 2	Homo sapiens	94-99
15585864-9	2004	In the C-terminal arm, key stabilizing contacts are made, including critical hydrogen bonds with Gln(379) in TRAF3 that define the molecular basis for selective binding of BAFF-R solely to this member of the TRAF family.	Hydrogen	77-85	TNF receptor associated factor 3	Homo sapiens	109-114
7756285-2	1995	The 1H, 15N, and 13C NMR resonances of a recombinant human IL-3 variant (SC-65369) have been assigned using two- and three-dimensional NMR techniques on uniformly 13C/15N-enriched protein.	Hydrogen	4-6	interleukin 3	Homo sapiens	59-63
7721817-9	1995	1H NMR difference spectroscopy of antithrombin complexes with LAH and HAH and competitive binding studies were consistent with LAH accelerating activity being mediated by binding to the same site on the inhibitor as HAH.	Hydrogen	0-2	serpin family C member 1	Homo sapiens	34-46
15501037-3	2004	The cytosolic isozyme hCA I was weakly inhibited by neutral phosphate, strongly inhibited by carbamoyl phosphate (K(I) of 9.4 microM), and activated by hydrogen- and dihydrogenphosphate, foscarnet and formate (best activator foscarnet, K(A)=12 microM).	Hydrogen	152-160	carbonic anhydrase 1	Homo sapiens	22-27
31180482-6	2019	N15 Cro makes fewer direct contacts and hydrogen bonds to bases, relying mostly on water-mediated and Van der Waals contacts to recognize the sequence.	Hydrogen	40-48	cro	Escherichia virus Lambda	4-7
31324778-6	2019	The lack of a strict three-dimensional recognition arrangement, typical of hydrogen bonds, permits two different orientations for beta (1-3) sugar addition.	Hydrogen	75-83	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	130-139
7718558-6	1995	Isotope-aided 1H-NMR spectroscopy demonstrates that analogous side-chain insertion occurs on binding of SRY to a four-way junction, establishing a shared mechanism of sequence- and structure-specific DNA binding.	Hydrogen	14-16	sex determining region Y	Homo sapiens	104-107
31330936-0	2019	Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p-Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver.	Hydrogen	20-28	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	80-94
15630566-0	2004	Assignment of the 1H, 13C, and 15N resonances of the Josephin domain of human ataxin-3.	Hydrogen	18-20	ataxin 3	Homo sapiens	78-86
15535723-5	2004	However, unlike the original BrF(3) and BrF(5) molecules, the global minima for HBrF(n)/HBrF(n)(-) (n = 2, 4) species are predicted to be complexes, some of which contain hydrogen bonds.	Hydrogen	171-179	BRF1 RNA polymerase III transcription initiation factor subunit	Homo sapiens	80-84
15535723-5	2004	However, unlike the original BrF(3) and BrF(5) molecules, the global minima for HBrF(n)/HBrF(n)(-) (n = 2, 4) species are predicted to be complexes, some of which contain hydrogen bonds.	Hydrogen	171-179	BRF1 RNA polymerase III transcription initiation factor subunit	Homo sapiens	88-92
31330936-0	2019	Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p-Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver.	Hydrogen	20-28	ATP binding cassette subfamily C member 2	Rattus norvegicus	100-141
15527770-5	2004	However, ISG20 also has distinctive residues, Met14 and Arg53, to accommodate hydrogen bonds with the 2"-OH group of the UMP ribose, and these residues may be responsible for the preference of ISG20 for RNA substrates.	Hydrogen	78-86	interferon stimulated exonuclease gene 20	Homo sapiens	9-14
7707377-5	1995	W24 and E30 are conserved residues that form hydrogen bonds with WatE in crystal structures of DHFR.	Hydrogen	45-53	dihydrofolate reductase	Homo sapiens	95-99
15527770-5	2004	However, ISG20 also has distinctive residues, Met14 and Arg53, to accommodate hydrogen bonds with the 2"-OH group of the UMP ribose, and these residues may be responsible for the preference of ISG20 for RNA substrates.	Hydrogen	78-86	interferon stimulated exonuclease gene 20	Homo sapiens	193-198
7707379-12	1995	We note that the O-10" atom on the carbamate side-chain of MC forms an intermolecular hydrogen bond with the exocyclic amino group of dG15 in two of the three refined structures of the complex.	Hydrogen	86-94	immunoglobulin kappa variable 3D-31 (pseudogene)	Homo sapiens	17-22
7708669-5	1995	Comparison with the crystal structures of H-2Kb in complex with peptides VSV-8 (RGYVYQGL) and SEV-9 (FAPGNYPAL), where a Tyr residue is used as the C pocket anchor, reveals that the conserved water molecule that binds into the B pocket and mediates hydrogen bonding from the buried anchor hydroxyl group could not be likewise positioned if the P2 side chain were of significant size.	Hydrogen	249-257	histocompatibility 2, K1, K region	Mus musculus	42-47
15514152-3	2004	This energy equals the latent heat of melting of ice with hexagonal symmetry (ice Ih) and is consistent with the distribution of hydrogen bond strengths obtained for the "overstructured" ST2 model of water.	Hydrogen	129-137	ST2	Homo sapiens	187-190
31125206-1	2019	The role of carbones (CL2; L = phosphines vs carbenes) as Lewis bases in dihydrogen (H2) activation reactions in the presence of the Lewis acid B(C6F5)3 has been computationally explored by means of density functional theory calculations.	Hydrogen	85-87	endogenous retrovirus group W member 5	Homo sapiens	22-25
7702579-6	1995	plate, tentatively termed XN-1 and XN-2, were isolated, and their chemical structures were characterized by gas chromatography-mass spectrometry, immunological anlaysis, fast-atom-bombardment mass spectrometry and 1H-n.m.r.	Hydrogen	214-216	nuclear receptor corepressor 1 L homeolog	Xenopus laevis	26-39
31125206-5	2019	Our calculations identify heavier EL2 as the most active systems to achieve facile H2 activation reactions.	Hydrogen	83-85	spectrin alpha, erythrocytic 1	Homo sapiens	34-37
31135801-5	2019	Here, by a "best-match for hydrogen-bonding pair" (BMHP) computational protocol and molecular dynamics (MD) simulations, we model the atomic structure of KRas4B in complex with the Ras binding domain (RBD) of PI3Kalpha, striving to understand the mechanism of PI3Kalpha activation by Ras.	Hydrogen	27-35	KRAS proto-oncogene, GTPase	Homo sapiens	154-160
15553681-10	2004	The second was a H2 case treated effectively by intra-hepatic arterial infusion of CDDP and peroral administration of 5"-DFUR and PSK.	Hydrogen	17-19	TAO kinase 2	Homo sapiens	130-133
15331163-5	2004	On examination of the expression profiles of PLC isozymes after treatment of neurons with SNAP, PLC-beta1 was found to be increased after 1h treatment and decreased after 9 h treatment, while PLC-delta1 was significantly increased, especially after 5 h treatment.	Hydrogen	138-140	phospholipase C beta 1	Rattus norvegicus	96-105
15243190-0	2004	1H, 13C, 15N resonance assignments of the cytokine LECT2.	Hydrogen	0-2	leukocyte cell derived chemotaxin 2	Homo sapiens	51-56
7788295-6	1995	CONCLUSIONS: In addition to the intermolecular disulfide bridge between Cys32 of human thioredoxin and Cys62 of the peptide, the complex is stabilized by numerous hydrogen-bonding, electrostatic and hydrophobic interactions which involve residues 57-65 of the NF kappa B peptide and confer substrate specificity.	Hydrogen	163-171	thioredoxin	Homo sapiens	87-98
15306462-10	2004	The effect on binding stability can be interpreted in terms of conformational freedom and major-groove space available to BP due to the hydrogen bonds and inserted phenylalanines of the TATA-TBP complex; that is, depending on the position of the adenine to which BP is covalently bound, BP can be accommodated in an intercalated or major-groove orientation with ease or with difficulty (due to interference with TATA-TBP interactions).	Hydrogen	136-144	TATA-box binding protein	Homo sapiens	191-194
15306462-10	2004	The effect on binding stability can be interpreted in terms of conformational freedom and major-groove space available to BP due to the hydrogen bonds and inserted phenylalanines of the TATA-TBP complex; that is, depending on the position of the adenine to which BP is covalently bound, BP can be accommodated in an intercalated or major-groove orientation with ease or with difficulty (due to interference with TATA-TBP interactions).	Hydrogen	136-144	TATA-box binding protein	Homo sapiens	417-420
31000234-10	2019	Modeling docking predicted that osthole bound to the hydrophobic cavity of BLG through stable hydrogen bonds primarily with the amino acid residues Lys75 and Thr76.	Hydrogen	94-102	beta-lactoglobulin	Bos taurus	75-78
31046258-5	2019	The 1H-hyperfine for ArP3BFe(NNH) derived from the presented ENDOR studies is diagnostic for the distally bound H atom ( aiso = 16.5 MHz).	Hydrogen	4-6	actin related protein 3	Homo sapiens	21-28
7703700-4	1995	These assignments also provide the basis for interpreting 1H alpha-13C alpha heteronuclear NOE (HNOE) values in mEGF at natural isotope abundance.	Hydrogen	58-60	epidermal growth factor	Mus musculus	112-116
31113492-11	2019	IHC and immunofluorescence staining demonstrated that hydrogen treatment markedly downregulated the expression of markers involved in stemness (CD133, Nestin), proliferation (ki67), and angiogenesis (CD34) and also upregulated GFAP expression, a marker of differentiation.	Hydrogen	54-62	prominin 1	Mus musculus	144-149
30964290-6	2019	Furthermore, docking into human HDAC10 homology models indicated that a hydrogen bond between a cap group nitrogen and the gatekeeper residue Glu272 was responsible for potent HDAC10 binding.	Hydrogen	72-80	histone deacetylase 10	Homo sapiens	32-38
30964290-6	2019	Furthermore, docking into human HDAC10 homology models indicated that a hydrogen bond between a cap group nitrogen and the gatekeeper residue Glu272 was responsible for potent HDAC10 binding.	Hydrogen	72-80	histone deacetylase 10	Homo sapiens	176-182
15183130-4	2004	In continuation of our studies on structure optimization of EPPN derivatives, a series of 12 novel spin traps with 2-, 3- and 4-pyridinyl substituents was synthesized and fully characterized by 1H NMR, 13C NMR and IR spectroscopy.	Hydrogen	194-196	spindlin 1	Homo sapiens	99-103
7767440-2	1995	Chit-PEG interpenetrating net work (IPN) had been synthesised by crosslinking different ratios of chitosan with glutaraldehyde using schiffs base reaction mechanism and interpenetrating polyethyleneglycol (PEG) to form hydrogen bonding between the amino hydrogen in chitosan and polyether oxygen.	Hydrogen	219-227	chitinase 1	Homo sapiens	0-4
21782725-5	2004	A 1h post incubation with either NAC or GSH after Compound 1 addition failed to protect the cells from toxicity (P &lt; 0.001).	Hydrogen	2-4	X-linked Kx blood group	Homo sapiens	33-36
15189865-5	2004	Energy calculations using the Empirical Conformation Energy Program for Peptides (ECEPP)/2 force field and the implicit solvent model show that the middle of the peptide helix accommodates a bifurcated hydrogen bond that is simultaneously formed between HN Aib(12) and CO Leu(8) and CO Aib(9).	Hydrogen	202-210	ANIB1	Homo sapiens	257-260
15189865-5	2004	Energy calculations using the Empirical Conformation Energy Program for Peptides (ECEPP)/2 force field and the implicit solvent model show that the middle of the peptide helix accommodates a bifurcated hydrogen bond that is simultaneously formed between HN Aib(12) and CO Leu(8) and CO Aib(9).	Hydrogen	202-210	ANIB1	Homo sapiens	286-289
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Hydrogen	44-46	DNA methyltransferase 1	Homo sapiens	96-101
30735837-8	2019	We also found that hydrogen decreased the expression of the DNA damage-related protein ATM, cyclinD1 and NF-kappaB but increased the expression of the DNA repair-related protein HMGB1, suggesting that hydrogen inhibits senescence in retinas of NaIO3 mice.	Hydrogen	19-27	cyclin D1	Mus musculus	92-100
15189865-8	2004	NMR parameters ((1)HN chemical shifts and transpeptide bond (1)J(NC") couplings) sensitive to hydrogen bonding along with the solvent accessible surface area of carbonyl oxygens indicate a large polar patch on the convex side of the helix formed by three exposed backbone carbonyls of Aib(7), Aib(9), and Hyp(10) and polar side chains of Hyp(10), Gln(11), and Hyp(13).	Hydrogen	94-102	ANIB1	Homo sapiens	285-288
15189865-8	2004	NMR parameters ((1)HN chemical shifts and transpeptide bond (1)J(NC") couplings) sensitive to hydrogen bonding along with the solvent accessible surface area of carbonyl oxygens indicate a large polar patch on the convex side of the helix formed by three exposed backbone carbonyls of Aib(7), Aib(9), and Hyp(10) and polar side chains of Hyp(10), Gln(11), and Hyp(13).	Hydrogen	94-102	ANIB1	Homo sapiens	293-296
7767440-2	1995	Chit-PEG interpenetrating net work (IPN) had been synthesised by crosslinking different ratios of chitosan with glutaraldehyde using schiffs base reaction mechanism and interpenetrating polyethyleneglycol (PEG) to form hydrogen bonding between the amino hydrogen in chitosan and polyether oxygen.	Hydrogen	254-262	chitinase 1	Homo sapiens	0-4
7734844-3	1994	This conformation is stabilized by the formation of a hydrogen bond between the carbonyl oxygen of GlcNAc2 with the O3/O4 hydroxyls of the alpha 1,6-linked mannose residue.	Hydrogen	54-62	adrenoceptor alpha 1D	Homo sapiens	139-148
15136842-0	2004	Stereochemistry of hydrogen removal from the "unactivated" C-3 position of 4-hydroxybutyryl-CoA catalysed by 4-hydroxybutyryl-CoA dehydratase.	Hydrogen	19-27	complement C3	Homo sapiens	59-62
30735837-8	2019	We also found that hydrogen decreased the expression of the DNA damage-related protein ATM, cyclinD1 and NF-kappaB but increased the expression of the DNA repair-related protein HMGB1, suggesting that hydrogen inhibits senescence in retinas of NaIO3 mice.	Hydrogen	201-209	cyclin D1	Mus musculus	92-100
31043594-3	2019	The barrier heights of the mechanistic pathways are unexpectedly low - about 2-3 kcal/mol - and are at least 10 kcal/mol lower than those of hydrogen shift processes in large syn Criegee intermediates; and the calculated rate constants show that the mechanistic pathways are 105-109 times faster than those of the corresponding hydrogen shift processes.	Hydrogen	141-149	synemin	Homo sapiens	175-178
31043594-3	2019	The barrier heights of the mechanistic pathways are unexpectedly low - about 2-3 kcal/mol - and are at least 10 kcal/mol lower than those of hydrogen shift processes in large syn Criegee intermediates; and the calculated rate constants show that the mechanistic pathways are 105-109 times faster than those of the corresponding hydrogen shift processes.	Hydrogen	328-336	synemin	Homo sapiens	175-178
7756994-0	1994	Mass spectrometric measurement of protein amide hydrogen exchange rates of apo- and holo-myoglobin.	Hydrogen	48-56	myoglobin	Homo sapiens	89-98
30900877-0	2019	New Simultaneous Exfoliation and Doping Process for Generating MX2 Nanosheets for Electrocatalytic Hydrogen Evolution Reaction.	Hydrogen	99-107	MX dynamin like GTPase 2	Homo sapiens	63-66
30900877-1	2019	Doping nonmetal atoms into layered transition metal dichalcogenide MX2 structures has emerged as a promising strategy for enhancing their catalytic activities for the hydrogen evolution reaction.	Hydrogen	167-175	MX dynamin like GTPase 2	Homo sapiens	67-70
15116180-1	2004	The calix[4]arene dihydroxyphosphonic acid-1,10-phenanthroline complex shows caging of the guest molecules as a pi-pi stacked dimer in a cavity formed by intermolecular hydrogen bonds and aromatic walls formed by the calixarene.	Hydrogen	169-177	mediator complex subunit 25	Homo sapiens	38-44
7961686-3	1994	The 25-kDa enzyme is now shown to be a peroxidase that reduces H2O2 and alkyl hydroperoxides with the use of hydrogens provided by thioredoxin, thioredoxin reductase, and NADPH.	Hydrogen	109-118	thioredoxin	Homo sapiens	131-142
15017146-0	2004	1H, 13C and 15N backbone resonance assignments of the hyaluronan-binding domain of CD44.	Hydrogen	0-2	CD44 molecule (Indian blood group)	Homo sapiens	83-87
31073393-12	2019	During 30 ns simulation, the candidate inhibitors established &lt;3.0 A root mean square deviation and stable hydrogen bond interactions with the ATP-binding site residues of Cdk5/p25.	Hydrogen	110-118	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	180-183
14978234-5	2004	These models reveal that hCNT2 affinity is dominated by hydrogen bonding features, whereas hCNT1 and hENT1 displayed mainly electrostatic and steric features.	Hydrogen	56-64	solute carrier family 28 member 2	Homo sapiens	25-30
7961686-4	1994	This protein is the first peroxidase to be identified that uses thioredoxin as the immediate hydrogen donor and is thus named thioredoxin peroxidase (TPx).	Hydrogen	93-101	thioredoxin	Homo sapiens	64-75
30971271-7	2019	Mutating one of the hydrogen-bonds among the KRA-533 binding amino acids in KRAS (mutant K117A) resulted in failure of KRAS to bind KRA-533.	Hydrogen	20-28	KRAS proto-oncogene, GTPase	Homo sapiens	76-80
30971271-7	2019	Mutating one of the hydrogen-bonds among the KRA-533 binding amino acids in KRAS (mutant K117A) resulted in failure of KRAS to bind KRA-533.	Hydrogen	20-28	KRAS proto-oncogene, GTPase	Homo sapiens	119-123
7523674-6	1994	Cellular experiments indicate that replacement of the hydroxyl groups of fucose by hydrogen abrogated E-selectin binding.	Hydrogen	83-91	selectin E	Homo sapiens	102-112
30971693-4	2019	The hydrogen atoms donate electrons to the Ni d orbital and induce electron localization through strong electron correlations.	Hydrogen	4-12	nidogen 1	Mus musculus	43-47
15038278-1	2004	We report a theoretical study on seven radical hydrogen bond complexes between syn-HCOOH and OH and eight radical hydrogen bond complexes between anti-HCOOH and OH, that have been carried out by using the B3LYP, MP2, QCISD, and CCSD(T) theoretical approaches with the 6-311 + G(2df,2p) basis set.	Hydrogen	47-55	synemin	Homo sapiens	79-82
7520873-0	1994	Homology modelling and 1H NMR studies of human leukaemia inhibitory factor.	Hydrogen	23-25	LIF interleukin 6 family cytokine	Homo sapiens	47-74
15267283-5	2004	Since the calculated H2 cluster temperature (approximately 3.1 K) is below the superfluid transition temperature predicted for pH2 with density between 40% and 80% of the triple-point density, a shell-like region of low density near the cluster surface can be expected to be superfluid.	Hydrogen	21-23	polyhomeotic homolog 2	Homo sapiens	127-130
14640545-8	2003	Agonists missing a hydrogen-bond-accepting moiety, but possessing an aromatic substituent instead, seem to bind the receptor with high affinity as well by occupying a lipophilic pocket hosted by residues of TM5 and TM6.	Hydrogen	19-27	tropomyosin 3	Homo sapiens	207-210
30984322-1	2019	Amorphous molybdenum sulfide (MoS x ) is a potent catalyst for the hydrogen evolution reaction (HER).	Hydrogen	67-75	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	30-33
30734528-8	2019	The increased potency of JH-T4 is likely due to the formation of hydrogen bonding between the hydroxy group and SIRT1, SIRT2, and SIRT3.	Hydrogen	65-73	sirtuin 1	Homo sapiens	112-117
7520873-4	1994	It has been assessed by comparison with 1H NMR data on the ionization behaviour of the six histidine residues in LIF, the imidazolium pKa values of which range from 3.6 to 7.4.	Hydrogen	40-42	LIF interleukin 6 family cytokine	Homo sapiens	113-116
14645682-7	2003	The changes of binding energy between transporter proteins and different uridine analogs suggested that hCNT1 formed hydrogen bonds (H-bonds) with C(3")-OH, C(5")-OH, or N(3)-H of uridine, but not with C(2")-OH, whereas hCNT3 formed H-bonds to C(3")-OH, but not to N(3)-H, C(5")-OH, and C(2")-OH.	Hydrogen	117-125	solute carrier family 28 member 1	Homo sapiens	104-109
8062828-5	1994	To investigate the structural basis of receptor specificity, we have determined the solution structure of the EGF-like domain of HRG-alpha by two-dimensional 1H nuclear magnetic resonance spectroscopy and simulated annealing calculations.	Hydrogen	158-160	epidermal growth factor	Homo sapiens	110-113
15072436-1	2003	Three neurokinin (NK) antagonist pharmacophore models (Models 1-3) accounting for hydrogen bonding groups in the "head" and "tail" of NK receptor ligands have been developed by use of a new procedure for treatment of hydrogen bonds during superimposition.	Hydrogen	82-90	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	134-145
15072436-1	2003	Three neurokinin (NK) antagonist pharmacophore models (Models 1-3) accounting for hydrogen bonding groups in the "head" and "tail" of NK receptor ligands have been developed by use of a new procedure for treatment of hydrogen bonds during superimposition.	Hydrogen	217-225	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	134-145
30535613-5	2019	We report the complete backbone 1H, 13C, and 15N chemical shift assignment and secondary structure of hBAF200 ARID domain.	Hydrogen	32-34	AT-rich interaction domain 2	Homo sapiens	102-109
8033884-6	1994	Hydrogen-bonding interactions are almost exclusively restricted to the other side of the molecule: the C-4" and C-6" hydroxyl groups act as donors of the strongest hydrogen bonds to charged groups of the lectin, while the C-3 hydroxyl group participates in a strong hydrogen bond with a neutral group.	Hydrogen	0-8	complement C6	Bos taurus	112-115
30830594-0	2019	1H, 13C and 15N NMR assignments of Bacillus subtilis bacteriophage SPO1 protein Gp46.	Hydrogen	0-2	gp46	Bacillus phage SPO1	80-84
8033884-6	1994	Hydrogen-bonding interactions are almost exclusively restricted to the other side of the molecule: the C-4" and C-6" hydroxyl groups act as donors of the strongest hydrogen bonds to charged groups of the lectin, while the C-3 hydroxyl group participates in a strong hydrogen bond with a neutral group.	Hydrogen	0-8	complement C3	Bos taurus	222-225
8033884-6	1994	Hydrogen-bonding interactions are almost exclusively restricted to the other side of the molecule: the C-4" and C-6" hydroxyl groups act as donors of the strongest hydrogen bonds to charged groups of the lectin, while the C-3 hydroxyl group participates in a strong hydrogen bond with a neutral group.	Hydrogen	164-172	complement C6	Bos taurus	112-115
8033884-6	1994	Hydrogen-bonding interactions are almost exclusively restricted to the other side of the molecule: the C-4" and C-6" hydroxyl groups act as donors of the strongest hydrogen bonds to charged groups of the lectin, while the C-3 hydroxyl group participates in a strong hydrogen bond with a neutral group.	Hydrogen	266-274	complement C6	Bos taurus	112-115
12941540-3	2003	Computer modeling revealed that the side chains of 263F and 266E in CII263-272 were coupled with amino acids on alpha1 and beta1 chains of HLA-DR1 or -DR4, mainly via hydrogen bonds, whereas the side chains of 267Q and 270K protrude out of the cleft and might be recognized by TCR.	Hydrogen	167-175	major histocompatibility complex, class II, DR beta 4	Homo sapiens	151-154
8033884-6	1994	Hydrogen-bonding interactions are almost exclusively restricted to the other side of the molecule: the C-4" and C-6" hydroxyl groups act as donors of the strongest hydrogen bonds to charged groups of the lectin, while the C-3 hydroxyl group participates in a strong hydrogen bond with a neutral group.	Hydrogen	266-274	complement C3	Bos taurus	222-225
8195191-2	1994	In this study, we have elucidated the structure of this novel adduct with the use of mass spectrometry, as well as 1H and 13C NMR as a substitution product of a -C(Cl) = CCl2 moiety for a beta-hydrogen atom on the prosthetic heme"s ring I vinyl group.	Hydrogen	115-117	C-C motif chemokine ligand 2	Homo sapiens	170-174
30846557-2	2019	Tenapanor, a minimally absorbed inhibitor of gastrointestinal sodium/hydrogen exchanger 3 (NHE3), reduces paracellular phosphate transport.	Hydrogen	69-77	solute carrier family 9 member A3	Homo sapiens	91-95
30819565-6	2019	Under force, R577 on one protomer switches from interacting with S550 to forming new hydrogen bonds with E553 on the neighboring protomer, resulting in the strengthening of the kindlin2 dimer in complex with integrin beta1.	Hydrogen	85-93	integrin subunit beta 1	Homo sapiens	208-222
8195191-2	1994	In this study, we have elucidated the structure of this novel adduct with the use of mass spectrometry, as well as 1H and 13C NMR as a substitution product of a -C(Cl) = CCl2 moiety for a beta-hydrogen atom on the prosthetic heme"s ring I vinyl group.	Hydrogen	193-201	C-C motif chemokine ligand 2	Homo sapiens	170-174
8019145-0	1994	1H, 15N and 13C resonance assignments for the first three zinc fingers of transcription factor IIIA.	Hydrogen	0-2	general transcription factor 3A L homeolog	Xenopus laevis	74-99
30888509-4	2019	RESULTS: Synthesis of o(LA)8-RAP prodrug was confirmed by 1H NMR and mass spectroscopy.	Hydrogen	58-60	LDL receptor related protein associated protein 1	Rattus norvegicus	29-32
8161501-7	1994	The NMR spectrum and resulting solution structure of PAPA suggest that a side-chain to side-chain hydrogen bond involving an arginine and an aspartic acid analogous to one observed in the Zif268 protein-DNA cocrystal structure exists in solution in the absence of DNA [Pavletich, N. P., &amp; Pabo, C. O.	Hydrogen	98-106	early growth response 1	Homo sapiens	188-194
30804176-5	2019	Hydrogen/deuterium exchange-mass spectrometry (HDX-MS) mapped GCN2-ribosome interactions to domain II of the uL10 subunit of the ribosomal P-stalk.	Hydrogen	0-8	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	62-66
24222565-0	1994	Mechanistic study of hydrogen/deuterium exchange between [M - 1](-) ions of chlorinated benzenes and D 2O or ND 3.	Hydrogen	21-29	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	109-113
30287344-0	2019	Hydrogen-rich saline protects rat from oxygen glucose deprivation and reperusion-induced apoptosis through VDAC1 via Bcl-2.	Hydrogen	0-8	voltage-dependent anion channel 1	Rattus norvegicus	107-112
30287344-9	2019	RESULTS: In this study, we demonstrated that hydrogen-rich saline (HRS) reduced OGD/RP-mediated neuronal loss by stimulating the expression of Bcl-2, which suppressed the activity of VDAC1.	Hydrogen	45-53	voltage-dependent anion channel 1	Rattus norvegicus	183-188
30613850-6	2019	The probable mode of binding between the receptor and Hg2+ was confirmed by 1H NMR and Mass spectral study.	Hydrogen	76-78	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	54-57
7656052-1	1994	The dynamic behaviour of the complex of horse cytochrome c with cytochrome c peroxidase, an electron-transfer complex, was studied in solution by a hydrogen exchange labelling method together with two-dimensional NMR analysis.	Hydrogen	148-156	cytochrome c, somatic	Equus caballus	46-58
30681339-1	2019	We report a very significant cooperative effect of water-ammonia hydrogen bonding in their reactions with a Criegee intermediate, syn-CH3CHOO.	Hydrogen	65-73	synemin	Homo sapiens	130-133
30730751-2	2019	Such structures were recently reported in a cold chemistry experiment of ground-state hydrogen isotopologues (H2/HD) colliding with helium atoms in the excited triplet P-state (He(23P)) [Shagam et al.	Hydrogen	86-94	relaxin 2	Homo sapiens	110-115
30873235-4	2019	Screening of the library for p53-MDM2 inhibition by fluorescence polarization and 1H,15N HSQC NMR measurements confirm MDM2 binding.	Hydrogen	82-84	MDM2 proto-oncogene	Homo sapiens	33-37
30342410-4	2019	Surface protection of a CdS-covered CZTS photocathode by a ZnS layer resulted in efficient photoelectrochemical water splitting with a maximum half-cell solar to hydrogen (HC-STH) efficiency of 2.1% and without showing appreciable degradation.	Hydrogen	162-170	saitohin	Homo sapiens	175-178
30687857-1	2019	Ir-Complex catalysed hydrogen release/storage using a 2-methylindole/2-methylindoline Liquid Organic Hydrogen Carrier (LOHC) system is shown to be effective in a temperature range of 120 to 140  C. In the form of a liquid-liquid biphasic reaction system with molten [PPh4][NTf2] as catalyst immobilisation phase, the applied cationic Ir-complex can be easily separated and recycled enabling a small amount of ionic catalyst solution to store/release a large amount of hydrogen.	Hydrogen	21-29	nuclear transport factor 2	Homo sapiens	273-277
30687857-1	2019	Ir-Complex catalysed hydrogen release/storage using a 2-methylindole/2-methylindoline Liquid Organic Hydrogen Carrier (LOHC) system is shown to be effective in a temperature range of 120 to 140  C. In the form of a liquid-liquid biphasic reaction system with molten [PPh4][NTf2] as catalyst immobilisation phase, the applied cationic Ir-complex can be easily separated and recycled enabling a small amount of ionic catalyst solution to store/release a large amount of hydrogen.	Hydrogen	101-109	nuclear transport factor 2	Homo sapiens	273-277
30746761-5	2019	Dynamic simulation studies confirmed that the hydrogen bonding and hydrophobic interactions were highly stable in all the three isoforms of the RXR-bexarotene complex.	Hydrogen	46-54	retinoid X receptor alpha	Homo sapiens	144-147
30587448-6	2019	Docking studies revealed strong interactions between ZL0177 and Nav1.6, mediated by hydrogen bonds, cation-pi interactions and hydrophobic contacts.	Hydrogen	84-92	sodium voltage-gated channel alpha subunit 8	Homo sapiens	64-70
12775713-7	2003	The binding of DHEA to MAP2C involved specific hydrogen bonds that orient the steroid into the pocket.	Hydrogen	47-55	microtubule associated protein 2	Homo sapiens	23-28
12966073-5	2003	The side chain of Arg169 in sAPX corresponding to His169 in cAPX and His181 in CCP extended in the opposite direction from the heme, forming two hydrogen bonds with carbonyl groups in the loop structure.	Hydrogen	145-153	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	79-82
12888491-7	2003	The ACAA tetraloop is stabilized by an equilateral 5" and 3" stacking pattern, a sheared A-A pair and a cross-strand hydrogen bond.	Hydrogen	117-125	acetyl-CoA acyltransferase 1	Homo sapiens	4-8
12813364-9	2003	In addition, we observed less caspase-3 activation in the small intestine of the HS+SB group compared with the 2LR+SB group at 2 h after resuscitation.	Hydrogen	81-83	caspase 3	Mus musculus	30-39
12817146-0	2003	Spin-polarized hydrogen atoms from molecular photodissociation.	Hydrogen	15-23	spindlin 1	Homo sapiens	0-4
12817146-1	2003	The production of spin-polarized hydrogen atoms from the photodissociation of hydrogen chloride with circularly polarized 193-nanometer light is inferred from the measurement of the complete angular momentum distributions of ground state Cl(2P3/2)and excited state Cl(2P1/2)cofragments by slice imaging.	Hydrogen	33-41	spindlin 1	Homo sapiens	18-22
12761411-2	2003	The adducts exhibit a layered structure in which the packing between HMT and Cn is determined by strong hydrogen bonds.	Hydrogen	104-112	histamine N-methyltransferase	Homo sapiens	69-72
12761411-8	2003	The quality of the refinements leads to a conclusive model for the O-H.N hydrogen bonds linking HMT and C11.	Hydrogen	73-81	histamine N-methyltransferase	Homo sapiens	96-99
12761411-8	2003	The quality of the refinements leads to a conclusive model for the O-H.N hydrogen bonds linking HMT and C11.	Hydrogen	73-81	RNA polymerase III subunit K	Homo sapiens	104-107
7656052-1	1994	The dynamic behaviour of the complex of horse cytochrome c with cytochrome c peroxidase, an electron-transfer complex, was studied in solution by a hydrogen exchange labelling method together with two-dimensional NMR analysis.	Hydrogen	148-156	cytochrome c, somatic	Equus caballus	64-76
7656052-2	1994	Although cytochrome c hydrogens in the expected binding region exhibit slowed exchange, the measured slowing factors are very small, indicating that hydrogen-exchange occurs with little hindrance from within the binding interface.	Hydrogen	22-31	cytochrome c, somatic	Equus caballus	9-21
7656052-2	1994	Although cytochrome c hydrogens in the expected binding region exhibit slowed exchange, the measured slowing factors are very small, indicating that hydrogen-exchange occurs with little hindrance from within the binding interface.	Hydrogen	22-30	cytochrome c, somatic	Equus caballus	9-21
12794359-2	2003	The cations are linked to form an R(4)(4)(30) ring with two arms and are then linked into columns in the [010] direction by C(11) chains formed via C-H.N hydrogen bonds.	Hydrogen	154-162	RNA polymerase III subunit K	Homo sapiens	124-129
8294406-0	1994	Hydrogen bonding interaction of thyrotropin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor.	Hydrogen	0-8	thyrotropin releasing hormone receptor	Homo sapiens	107-119
8288565-2	1994	A genetically engineered human myoglobin (Mb) in which the distal His, His64(E7), and the distal Val, Val68(E11), are replaced by Val and His, respectively, has been expressed in Escherichia coli, for the purpose of assessing the potential role of a E11 residue in providing a hydrogen bond donor to the coordinated ligand.	Hydrogen	277-285	myoglobin	Homo sapiens	31-40
8289201-3	1994	The arrangement of these side chains was P-shaped, and the percentage of the intramolecular hydrogen-bonded molecules with the 15-membered ring in CCl4 solution showed a high value of ca.	Hydrogen	92-100	C-C motif chemokine ligand 4	Homo sapiens	147-151
12757562-9	2003	Subjects with a positive hydrogen breath test consumed significantly less fiber, folic acid, and vitamins B2 and B6 than those without.	Hydrogen	25-33	immunoglobulin kappa variable 5-2	Homo sapiens	106-115
7597933-0	1994	1H NMR approach to observe tissue oxygenation with the signals of myoglobin.	Hydrogen	0-2	myoglobin	Homo sapiens	66-75
12713833-4	2003	Based on the X-ray crystal structure of the adducts of hCA II with ureate and hydroxamate inhibitors, the hypothetical binding of hydroxyurea is proposed to be achieved in deprotonated state, with the nitrogen atom coordinated to Zn(II), and the OH group of the inhibitor making a hydrogen bond with Thr 199.	Hydrogen	281-289	carbonic anhydrase 2	Homo sapiens	55-61
12716176-10	2003	The heterolytic BDE was estimated for the hydride transfer reaction 1H --&gt; 1+ + H(-) (BDE approximately 127 kcal/mol).	Hydrogen	68-70	homeobox D13	Homo sapiens	89-92
8281918-8	1993	The conformation of ribose phosphate is such that O2" is at a distance of 0.31 nm from phosphorus, and opposite the P-OP3 bond which accepts a hydrogen bond from His92 N epsilon H+; we infer from a model building study that this bond is equivalent to the scissile P-O5" in a substrate GpN.	Hydrogen	143-151	pyrin domain containing 5	Homo sapiens	116-121
12799286-6	2003	By contrast, the combination of anti-CD45 and an otherwise inactive dose of total-body irradiation allowed engraftment of H2 fully allogeneic donor stem cells.	Hydrogen	122-124	protein tyrosine phosphatase receptor type C	Homo sapiens	37-41
10007695-0	1993	Effect of hydrogen doping on the properties of Sm1.93Sr0.07CuO4.	Hydrogen	10-18	SM1	Homo sapiens	47-50
12699376-19	2003	These structures reveal that the single amino acid difference in the ligand binding pocket (Ser277 in TRalpha or Asn331 in TRbeta) results in a slightly different hydrogen bonding pattern that may explain the increased beta-selectivity of 15.	Hydrogen	163-171	T cell receptor alpha locus	Homo sapiens	102-109
7804366-0	1993	The tyrosine residue at position 97 in the VH CDR3 region of a mouse/human chimeric anti-colorectal carcinoma antibody contributes hydrogen bonding to the TAG72 antigen.	Hydrogen	131-139	cerebellar degeneration-related 3	Mus musculus	46-50
8369294-1	1993	In thymidylate synthase (TS, EC 2.1.1.45), the only side chain in direct hydrogen bonding with the pyrimidine ring of the substrate dUMP is asparagine 229 (N229).	Hydrogen	73-81	thymidylate synthetase	Homo sapiens	3-23
12433683-8	2003	By contrast, the combination of anti-CD45 and an otherwise inactive dose of total-body irradiation allowed engraftment of H2 fully allogeneic donor stem cells.	Hydrogen	122-124	protein tyrosine phosphatase receptor type C	Homo sapiens	37-41
12617670-8	2003	Solvent-induced topological isomerism of these 3-D hydrogen-bonded networks of 1 arises from (i) the guest inclusion ability based on a radially functionalized hexagonal structure of 1, (ii) the correlation between the hydrogen bond donor ability of the syn and anti protons of the primary amide group in host 1 and the hydrogen bond acceptor ability of the oxygen atoms of 1 and guest solvents, and (iii) the polarity of the bulk crystallization solvents.	Hydrogen	51-59	synemin	Homo sapiens	254-257
12617670-8	2003	Solvent-induced topological isomerism of these 3-D hydrogen-bonded networks of 1 arises from (i) the guest inclusion ability based on a radially functionalized hexagonal structure of 1, (ii) the correlation between the hydrogen bond donor ability of the syn and anti protons of the primary amide group in host 1 and the hydrogen bond acceptor ability of the oxygen atoms of 1 and guest solvents, and (iii) the polarity of the bulk crystallization solvents.	Hydrogen	219-227	synemin	Homo sapiens	254-257
30699943-1	2019	In this report, the photocatalytic activity of P25 has been explored and the influence of thermal treatment under various atmospheres (air, vacuum and hydrogen) were discussed.	Hydrogen	151-159	tubulin polymerization promoting protein	Homo sapiens	47-50
12617670-8	2003	Solvent-induced topological isomerism of these 3-D hydrogen-bonded networks of 1 arises from (i) the guest inclusion ability based on a radially functionalized hexagonal structure of 1, (ii) the correlation between the hydrogen bond donor ability of the syn and anti protons of the primary amide group in host 1 and the hydrogen bond acceptor ability of the oxygen atoms of 1 and guest solvents, and (iii) the polarity of the bulk crystallization solvents.	Hydrogen	219-227	synemin	Homo sapiens	254-257
8257730-5	1993	In addition, the effect of freeze-drying on the 600 MHz 1H-NMR spectrum of human cerebrospinal fluid (CSF) is presented using both lyophilization with reconstitution into either H2O or D2O.	Hydrogen	56-58	colony stimulating factor 2	Homo sapiens	81-106
12603166-6	2003	A strained intramolecular hydrogen bond was found for conformers (G1 and T) with close NH(3)(+) and OH groups.	Hydrogen	26-34	proline rich protein BstNI subfamily 3	Homo sapiens	66-74
30800000-6	2019	Based on a 1H NMR-based metabolomics analysis, CLP-induced septic mice had increased levels of acetate, pyruvate, and lactate in serum and decreased levels of alanine, aspartate, glutamate, and fumarate in lungs.	Hydrogen	11-13	hyaluronan and proteoglycan link protein 1	Mus musculus	47-50
17750548-0	1993	Detection of interstellar pick-up hydrogen in the solar system.	Hydrogen	34-42	protein interacting with PRKCA 1	Homo sapiens	26-30
30470491-6	2019	Molecular docking suggested that the most potent compound 4 docked well in the ATP binding pocket of the four PDK isoforms, forming direct hydrogen bond interactions with the conserved amino acids Thr and Asp in ATP binding pocket of PDKs.	Hydrogen	139-147	pyruvate dehydrogenase kinase 1	Homo sapiens	234-238
12590568-0	2003	Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine alpha-hydroxylating monooxygenase: mechanistic implications.	Hydrogen	11-19	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	90-139
17750548-2	1993	This "pick-up" hydrogen is identified by its distinct velocity distribution function, which drops abruptly at twice the local solar wind speed.	Hydrogen	15-23	protein interacting with PRKCA 1	Homo sapiens	6-10
12593649-3	2003	The scaffold comprising the sulfonyl keto piperazine moiety might play a pivotal role in the orientation of substituents, since there is a strong hydrogen bond between Gly219 of fXa and the carbonyl oxygen of the piperazine.	Hydrogen	146-154	coagulation factor X	Homo sapiens	178-181
30788005-0	2019	Postconditioning with inhaled hydrogen attenuates skin ischemia/reperfusion injury through the RIP-MLKL-PGAM5/Drp1 necrotic pathway.	Hydrogen	30-38	receptor interacting serine/threonine kinase 1	Rattus norvegicus	95-98
17750548-3	1993	From the measured fluxes of pick-up protons and singly charged helium, the number densities of neutral hydrogen and helium in the distant regions of the solar system are estimated to be 0.077 +/- 0.015 and 0.013 +/- 0.003 per cubic centimeter, respectively.	Hydrogen	103-111	protein interacting with PRKCA 1	Homo sapiens	28-32
8368487-2	1993	The 13C chemical shift induced by 2H substitution for the C-2 of [2-13C,2-2H]-ibuprofen-CoA is about 0.5 ppm relative to the corresponding 1H-bearing thioester.	Hydrogen	139-141	complement C2	Rattus norvegicus	58-61
8357303-4	1993	1H-NMR spectroscopic studies on the 1,2-diphenylethylenediamine ligand reveal that the 2,6-standing Cl-atoms in meso-1 (antiperiplanar phenyl residues) hinder the rotation of the aromatic rings, which results in very stable conformers with different O-O distances owing to the unsymmetric arrangement of the ring substituents.	Hydrogen	0-2	transcription factor 15	Mus musculus	112-118
12537487-0	2003	Molecular dynamics and quantum chemical studies on the catalytic mechanism of Delta5-3-ketosteroid isomerase: the catalytic diad versus the cooperative hydrogen bond mechanism.	Hydrogen	152-160	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	84-108
12464242-2	2003	From a consideration of specific interactions between drug substrates for human CYP2 family enzymes and the putative active sites of CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, it is likely that the number and disposition of hydrogen bond donor/acceptors and aromatic rings within the various P450 substrate molecules determines their enzyme selectivity and binding affinity, together with directing their preferred routes of metabolism by the CYP2 enzymes concerned.	Hydrogen	242-250	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	133-139
12464242-2	2003	From a consideration of specific interactions between drug substrates for human CYP2 family enzymes and the putative active sites of CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, it is likely that the number and disposition of hydrogen bond donor/acceptors and aromatic rings within the various P450 substrate molecules determines their enzyme selectivity and binding affinity, together with directing their preferred routes of metabolism by the CYP2 enzymes concerned.	Hydrogen	242-250	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	165-172
12722112-5	2003	The order is mainly due to C3O3H...O5 and C4O4H...O5 hydrogen bonds that hinder rotations around beta(1-4) and beta(1-3) glycoside bonds.	Hydrogen	53-61	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	97-105
12722112-5	2003	The order is mainly due to C3O3H...O5 and C4O4H...O5 hydrogen bonds that hinder rotations around beta(1-4) and beta(1-3) glycoside bonds.	Hydrogen	53-61	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	111-119
8507639-0	1993	NMR studies of the POU-specific DNA-binding domain of Oct-1: sequential 1H and 15N assignments and secondary structure.	Hydrogen	72-74	POU class 2 homeobox 1	Homo sapiens	54-59
8507639-1	1993	The 1H and 15N resonances of the POU-specific DNA-binding domain of transcription factor Oct-1 have been assigned sequentially using two-dimensional homo- and heteronuclear NMR techniques, as well as three-dimensional heteronuclear NMR techniques, including TOCSY, 2D NOE, and NOESY-HMQC experiments.	Hydrogen	4-6	POU class 2 homeobox 1	Homo sapiens	89-94
12475225-7	2002	Results from hydrogen-deuterium exchange experiments indicated that beta-CRP is more dynamic than alpha-CRP.	Hydrogen	13-21	catabolite gene activator protein	Escherichia coli	73-76
8099293-2	1993	Ionization and hydrogen-bonding states of the two cysteine sulfhydryls (Cys32 and Cys35) in reduced thioredoxin were determined by monitoring the complex Raman SH stretching band (Li &amp; Thomas, 1991) as a function of pH in the range 4.0 &lt; pH &lt; 12.2.	Hydrogen	15-23	thioredoxin	Homo sapiens	100-111
12602343-1	2002	Spin label hyperfine splittings in mixtures of protic and aprotic solvents are used to obtain association constants K(A,h) for hydrogen bonding to oxazolidine nitroxides.	Hydrogen	127-135	spindlin 1	Homo sapiens	0-4
8441751-6	1993	Recent mutagenesis experiments evaluated in parallel with the structure reported here indicate that alterations in the hydrogen bonding environment of the side chain of rAsn-111 may be responsible for the homotropic behavior of the pAR5 mutant of ATCase.	Hydrogen	119-127	Prader Willi/Angelman region RNA 5	Homo sapiens	232-236
12451247-7	2002	RESULTS: Bone marrow transplantation studies indicate that H2-K(b), H2(s), and H2(v) serve as functional ligands for Ly49I(B6).	Hydrogen	59-61	killer cell lectin-like receptor subfamily A, member 9	Mus musculus	117-126
12451247-8	2002	In vitro cytotoxicity assays indicate that Ly49I recognizes H2(q), but not H2(d) or H2(k), target cells to inhibit NK killing.	Hydrogen	60-62	killer cell lectin-like receptor subfamily A, member 9	Mus musculus	43-48
12228253-2	2002	The high affinity of SHBG for 2-MeOE2 relies primarily on hydrogen bonding between the hydroxyl at C-3 of 2-MeOE2 and Asp(65) and an interaction between the methoxy group at C-2 and the amido group of Asn(82).	Hydrogen	58-66	complement C3	Homo sapiens	99-102
8454567-5	1993	The upfield shift of 2-13C of MCAD relative to that of FMN in the aqueous medium and its downfield shift relative to that of tetraacetylriboflavin in an apolar medium imply that a weaker hydrogen bond exists between C(2) = O and apoMCAD or a water molecule than that of free FMN with a water molecule.	Hydrogen	187-195	formin 1	Homo sapiens	55-58
12228253-6	2002	The higher affinity of SHBG for estradiol derivatives with a halogen atom at C-2 is due to either enhanced hydrogen bonding between the hydroxyl at C-3 and Asp(65) (2-fluoroestradiol) or accommodation of the functional group at C-2 (2-bromoestradiol), rather than an interaction with Asn(82).	Hydrogen	107-115	complement C3	Homo sapiens	148-151
12370832-3	2002	Thr18 phosphorylation has been shown to abolish side-chain hydrogen bonding between Thr18 and Asp21, an interaction necessary for stabilizing alpha-helical conformation within the transactivation domain.	Hydrogen	59-67	beta-secretase 2	Homo sapiens	94-99
12370832-4	2002	Mutagenesis-derived hydrogen bond disruption attenuated the interaction of p53 with the transactivation repressor Mdm-2 but had no direct effect on the interaction of p53 with the basal transcription factor TAF(II)31.	Hydrogen	20-28	MDM2 proto-oncogene	Homo sapiens	114-119
12370832-7	2002	We conclude disruption of intramolecular hydrogen bonding between Thr18 and Asp21 enhances p53 transactivation by modulating Mdm-2 binding, facilitating TAF(II)31 recruitment.	Hydrogen	41-49	beta-secretase 2	Homo sapiens	76-81
12370832-7	2002	We conclude disruption of intramolecular hydrogen bonding between Thr18 and Asp21 enhances p53 transactivation by modulating Mdm-2 binding, facilitating TAF(II)31 recruitment.	Hydrogen	41-49	MDM2 proto-oncogene	Homo sapiens	125-130
8454567-5	1993	The upfield shift of 2-13C of MCAD relative to that of FMN in the aqueous medium and its downfield shift relative to that of tetraacetylriboflavin in an apolar medium imply that a weaker hydrogen bond exists between C(2) = O and apoMCAD or a water molecule than that of free FMN with a water molecule.	Hydrogen	187-195	formin 1	Homo sapiens	275-278
8454567-6	1993	That the 4-13C resonance was observed downfield-shifted relative to that of free FMN in aqueous solution suggests a strong hydrogen bond between C(4) = O and apoMCAD.	Hydrogen	123-131	formin 1	Homo sapiens	81-84
1331071-7	1992	Binding is mediated by a two-prong electrostatic and hydrogen-binding interaction via arginines B13 and B17.	Hydrogen	53-61	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	96-99
12495033-0	2002	1H, 13C and 15N resonance assignments of Gads C-terminal SH3 domain in complex with an RXXK motif-containing peptide derived from SLP-76.	Hydrogen	0-2	lymphocyte cytosolic protein 2	Homo sapiens	130-136
12495034-0	2002	1H, 15N and 13C resonance assignments of the SH2 domain of Bruton"s tyrosine kinase.	Hydrogen	0-2	Bruton tyrosine kinase	Homo sapiens	59-83
12169661-1	2002	Na+/H+ exchanger regulatory factor (NHERF)-1 and NHERF-2, two structurally related protein adapters containing tandem PSD-95/Discs large/ZO-1 (PDZ) domains, were identified as essential factors for protein kinase A-mediated inhibition of the sodium-hydrogen exchanger, NHE3.	Hydrogen	249-257	discs large MAGUK scaffold protein 4	Mus musculus	118-124
1280117-0	1992	C-1" hydrogen abstraction of deoxyribose in DNA strand scission by dynemicin A.	Hydrogen	5-13	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	0-3
11994311-5	2002	In related GCN5 family structures, a hydroxyl-containing side chain residue is hydrogen-bonded to the alpha-phosphate oxygen of CoA.	Hydrogen	79-87	lysine acetyltransferase 2A	Homo sapiens	11-15
1280117-1	1992	Dynemicin A, which is a hybrid antitumor antibiotic containing anthraquinone and enediyne cores, abstracts the C-1" hydrogen of DNA deoxyribose and then the damaged DNA leads to strand breaks with the formation of 5"- and 3"-phosphate termini.	Hydrogen	116-124	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	111-114
12095258-0	2002	Native state hydrogen exchange study of suppressor and pathogenic variants of transthyretin.	Hydrogen	13-21	transthyretin	Homo sapiens	78-91
1280117-2	1992	The lesions of C-4" hydrogen also occur at 3" side of G.C base pairs (i. e., 5"-CT and 5"-GA), leading to 5"-phosphate and 3"-phosphoglycolate termini or 4"-hydroxylated abasic sites.	Hydrogen	20-28	complement C4A (Rodgers blood group)	Homo sapiens	15-18
12105892-3	2002	Modeling of the isotope effect data allows for a comparison to the hydrogen transfer catalyzed by soybean lipoxygenase in terms of environmental reorganization energy and frequency of the protein vibration that controls the hydrogen transfer.	Hydrogen	67-75	linoleate 9S-lipoxygenase-4	Glycine max	106-118
1280117-3	1992	The C-1" hydrogen abstraction by dynemicin A is distinct from the preferential C-5" hydrogen abstraction of calicheamicin and neocarzinostatin.	Hydrogen	9-17	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	4-7
12105892-3	2002	Modeling of the isotope effect data allows for a comparison to the hydrogen transfer catalyzed by soybean lipoxygenase in terms of environmental reorganization energy and frequency of the protein vibration that controls the hydrogen transfer.	Hydrogen	224-232	linoleate 9S-lipoxygenase-4	Glycine max	106-118
1327157-4	1992	Analysis of the data suggests that such suppression of hydrogen exchange occurs mainly for the Fab domains, but not for the Fc.	Hydrogen	55-63	FA complementation group B	Homo sapiens	95-98
12054929-6	2002	Clearly, DOIS recognizes the G-6-P substrate through specific hydrogen-bonding interactions, i.e., through a hydrogen-donating group for C-2 and an accepting group for C-3 of the substrate.	Hydrogen	62-70	complement C3	Homo sapiens	168-171
12222686-4	2002	These contacts, which are different in Msh2 and Msh6, likely facilitate stacking and hydrogen bonding interactions between side chains in Msh6 and the mismatched base, thus stabilizing a kinked DNA conformation that permits subsequent repair steps coordinated by the Mlh1-Pms1 heterodimer.	Hydrogen	85-93	mismatch repair ATPase MSH6	Saccharomyces cerevisiae S288C	48-52
12222686-4	2002	These contacts, which are different in Msh2 and Msh6, likely facilitate stacking and hydrogen bonding interactions between side chains in Msh6 and the mismatched base, thus stabilizing a kinked DNA conformation that permits subsequent repair steps coordinated by the Mlh1-Pms1 heterodimer.	Hydrogen	85-93	mismatch repair ATPase MSH6	Saccharomyces cerevisiae S288C	138-142
1327157-12	1992	Evidence suggests that the trans-interactions of the Fab domains may modulate the hydrogen exchange.	Hydrogen	82-90	FA complementation group B	Homo sapiens	53-56
12153047-0	2002	1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex.	Hydrogen	0-2	LIM domain only 4	Homo sapiens	56-60
1325657-6	1992	The amino-terminal nitrogen atom of the peptide forms a hydrogen bond with the hydroxyl group of Tyr-171 of H-2Kb at one end of the groove, while the carboxyl-terminal oxygen forms a hydrogen bond with the hydroxyl group of Tyr-84 at the other end.	Hydrogen	56-64	histocompatibility 2, K1, K region	Mus musculus	108-113
11993992-3	2002	In particular, homologous hydrogen-bonding networks involving a conserved basic residue (His 49 in Pdx, His 56 in Adx, Arg 49 in Tdx) are detailed.	Hydrogen	26-34	ferredoxin 1	Homo sapiens	114-117
11993992-5	2002	Hydrogen/deuterium exchange measurements have been made in Adx as a function of oxidation state for comparison with previous studies of Pdx and Tdx.	Hydrogen	0-8	ferredoxin 1	Homo sapiens	59-62
1496017-1	1992	Lesions in the gene encoding steroid 21-hydroxylase [steroid hydrogen-donor: oxygen oxidoreductase (21-hydroxylating), EC 1.14.99.10] result in defective adrenal steroid synthesis; the severe forms are known as congenital adrenal hyperplasia.	Hydrogen	61-69	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	29-51
11955021-5	2002	The end of beta-sheet beta1/beta5 at hydrogen bond E64--&gt;Q2 appears as the most thermolabile, whereas the adjacent hydrogen bond I3--&gt;L15 connecting beta-strands beta1 and beta2 is even stabilized slightly at higher temperatures.	Hydrogen	37-45	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	22-27
11955021-5	2002	The end of beta-sheet beta1/beta5 at hydrogen bond E64--&gt;Q2 appears as the most thermolabile, whereas the adjacent hydrogen bond I3--&gt;L15 connecting beta-strands beta1 and beta2 is even stabilized slightly at higher temperatures.	Hydrogen	118-126	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	22-27
11955021-5	2002	The end of beta-sheet beta1/beta5 at hydrogen bond E64--&gt;Q2 appears as the most thermolabile, whereas the adjacent hydrogen bond I3--&gt;L15 connecting beta-strands beta1 and beta2 is even stabilized slightly at higher temperatures.	Hydrogen	118-126	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	168-173
1605860-8	1992	Digestion with another methylation-sensitive enzyme, Bsa HI, which has a site between H2 and H4, showed that this region is methylated in intact adrenal cortex but nonmethylated both in cultured adrenocortical cells and in fibroblasts.	Hydrogen	86-88	albumin	Bos taurus	53-56
11955021-6	2002	Additional evidence for the stabilization of the beta1/beta2 beta-hairpin at higher temperatures is found in reduced hydrogen exchange rates for strand end residue V17.	Hydrogen	117-125	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	49-65
1325687-5	1992	By complementarity, in the sodium-channel receptor for TTX, there must be a hydrogen-acceptor group for the C-6 -OH, and another for the C-11 -OH.	Hydrogen	76-84	complement C6	Rattus norvegicus	108-111
30416039-3	2019	Using solution nuclear magnetic resonance spectroscopy, hydrogen/deuterium exchange mass spectrometry, and molecular dynamics simulations, we show that the putative canonical Nurr1 LBP is dynamic with high solvent accessibility, exchanges between two or more conformations on the microsecond-to-millisecond timescale, and can expand from the collapsed crystallized conformation to allow binding of unsaturated fatty acids.	Hydrogen	56-64	nuclear receptor subfamily 4 group A member 2	Homo sapiens	175-180
1554726-1	1992	The electrostatic behavior of potentially titrating groups in reduced human thioredoxin was investigated using two-dimensional (2D) 1H and 15N nuclear magnetic resonance (NMR) spectroscopy.	Hydrogen	132-134	thioredoxin	Homo sapiens	76-87
30416039-3	2019	Using solution nuclear magnetic resonance spectroscopy, hydrogen/deuterium exchange mass spectrometry, and molecular dynamics simulations, we show that the putative canonical Nurr1 LBP is dynamic with high solvent accessibility, exchanges between two or more conformations on the microsecond-to-millisecond timescale, and can expand from the collapsed crystallized conformation to allow binding of unsaturated fatty acids.	Hydrogen	56-64	lipopolysaccharide binding protein	Homo sapiens	181-184
11893211-0	2002	Synthesis of 2,3-anti-3,4-anti and 2,3-anti-3,4-syn propionate motifs: a diastereoselective tandem sequence of Mukaiyama and free-radical-based hydrogen transfer reactions.	Hydrogen	144-152	synemin	Homo sapiens	48-51
11893211-1	2002	[reaction: see text] Reported herein is a strategy employing a Mukaiyama reaction in tandem with a hydrogen transfer reaction for the elaboration of 2,3-anti-3,4-anti and 2,3-anti-3,4-syn propionate motifs.	Hydrogen	99-107	synemin	Homo sapiens	184-187
1605801-1	1992	Preferable conformations of thyrotropin-releasing hormone (TRH, Glp-His-Pro-NH2) and its analogues Glp-Glu(R)-Pro-NH2 (R = NHCH(CH3)CH2Ar), Glp-Gln-Abu-NH2, Dho-Gln-Abu-NH2 in DMSO solution are determined using two-dimensional 1H NMR spectroscopy (delta-J-correlated, COSY and NOESY).	Hydrogen	227-229	euchromatic histone lysine methyltransferase 1	Homo sapiens	64-67
11991360-0	2002	1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR.	Hydrogen	0-2	serine and arginine repetitive matrix 1	Homo sapiens	86-92
1605801-1	1992	Preferable conformations of thyrotropin-releasing hormone (TRH, Glp-His-Pro-NH2) and its analogues Glp-Glu(R)-Pro-NH2 (R = NHCH(CH3)CH2Ar), Glp-Gln-Abu-NH2, Dho-Gln-Abu-NH2 in DMSO solution are determined using two-dimensional 1H NMR spectroscopy (delta-J-correlated, COSY and NOESY).	Hydrogen	227-229	euchromatic histone lysine methyltransferase 1	Homo sapiens	99-102
1605801-1	1992	Preferable conformations of thyrotropin-releasing hormone (TRH, Glp-His-Pro-NH2) and its analogues Glp-Glu(R)-Pro-NH2 (R = NHCH(CH3)CH2Ar), Glp-Gln-Abu-NH2, Dho-Gln-Abu-NH2 in DMSO solution are determined using two-dimensional 1H NMR spectroscopy (delta-J-correlated, COSY and NOESY).	Hydrogen	227-229	euchromatic histone lysine methyltransferase 1	Homo sapiens	99-102
11989718-8	2002	Evaluation of the interaction surfaces, including hydrophobic patch, shape, hydrogen bonding, and electrostatic compatibility, strongly suggested that the drosophila insulin receptor is a substrate of the DPTP.	Hydrogen	76-84	Insulin-like receptor	Drosophila melanogaster	155-182
1624936-7	1992	In addition, binding studies of [Pt2(bipy)2(DSA)]Cl2 and [Pd2(bipy)2(DAA)]Cl2 to calf thymus DNA have been carried out and the mode of binding seems to be hydrogen bonding, as suggested earlier for analogous mononuclear amino acid-DNA complexes.	Hydrogen	155-163	doublecortin-like kinase 2	Mus musculus	49-52
12785105-6	2002	The hydrophobic domain of elastin is best described as a compact amorphous structure with distorted beta-strands, fluctuating turns, buried hydrophobic residues, and main-chain polar atoms that from hydrogen bonds with water.	Hydrogen	199-207	elastin	Homo sapiens	26-33
1624936-7	1992	In addition, binding studies of [Pt2(bipy)2(DSA)]Cl2 and [Pd2(bipy)2(DAA)]Cl2 to calf thymus DNA have been carried out and the mode of binding seems to be hydrogen bonding, as suggested earlier for analogous mononuclear amino acid-DNA complexes.	Hydrogen	155-163	doublecortin-like kinase 2	Mus musculus	74-77
1730598-8	1992	Infrared experiments showed that the hydrogen-deuterium exchange rate is much higher for TGF-alpha than for EGF, indicating that TGF-alpha is a more flexible molecule.	Hydrogen	37-45	epidermal growth factor	Homo sapiens	108-111
1787733-2	1991	The hydrolysis of an ATP molecule is assumed to produce the excitation of hydrogen bonds A--H...B between electronegative atoms A and B, which are contained in the myosin head and actin filament.	Hydrogen	74-82	myosin heavy chain 14	Homo sapiens	164-170
17474600-9	2002	The STARTECH plasma system operates in a reducing environment for the processing of organic waste and is designed to produce syn-gas, which can contain up to 60% of hydrogen.	Hydrogen	165-173	synemin	Homo sapiens	125-128
1824254-7	1991	However, the effect of IFN-gamma on intracellular pH and DNA synthesis was transient and pretreatment with IFN markedly inhibited the ability of GM-CSF, M-CSF, and IL-3 to activate the sodium/hydrogen antiport.	Hydrogen	192-200	colony stimulating factor 2	Homo sapiens	145-151
11641390-6	2001	Purified Msh2-Msh6 with substitutions in the conserved Phe(337) and Glu(339) in Msh6 thought to stack or hydrogen bond, respectively, with the mismatched base do have reduced DNA binding affinity but normal ATPase activity.	Hydrogen	105-113	mismatch repair ATPase MSH6	Saccharomyces cerevisiae S288C	14-18
11641390-6	2001	Purified Msh2-Msh6 with substitutions in the conserved Phe(337) and Glu(339) in Msh6 thought to stack or hydrogen bond, respectively, with the mismatched base do have reduced DNA binding affinity but normal ATPase activity.	Hydrogen	105-113	mismatch repair ATPase MSH6	Saccharomyces cerevisiae S288C	80-84
11641390-7	2001	Moreover, wild-type Msh2-Msh6 binds with lower affinity to mismatches with thymine replaced by difluorotoluene, which lacks the ability to hydrogen bond.	Hydrogen	139-147	mismatch repair ATPase MSH6	Saccharomyces cerevisiae S288C	25-29
11641390-8	2001	The results suggest that yeast Msh2-Msh6 interacts asymmetrically with the DNA through base-specific stacking and hydrogen bonding interactions and backbone contacts.	Hydrogen	114-122	mismatch repair ATPase MSH6	Saccharomyces cerevisiae S288C	36-40
11824760-0	2001	1H, 15N and 13C assignments of FLIN2, an intramolecular LMO2:ldb1 complex.	Hydrogen	0-2	LIM domain only 2	Homo sapiens	56-60
1824254-7	1991	However, the effect of IFN-gamma on intracellular pH and DNA synthesis was transient and pretreatment with IFN markedly inhibited the ability of GM-CSF, M-CSF, and IL-3 to activate the sodium/hydrogen antiport.	Hydrogen	192-200	colony stimulating factor 1	Homo sapiens	146-151
11555638-6	2001	Of most interest is the rearrangement of hydrogen bonding around the breach region that accompanies the stressed to relaxed transition, in particular the formation of a side chain hydrogen bond between the threonine at P14 and an adjacent tyrosine on strand 2 of beta-sheet B in relaxed PAI-2.	Hydrogen	41-49	ribonuclease P/MRP subunit p14	Homo sapiens	219-222
1824254-7	1991	However, the effect of IFN-gamma on intracellular pH and DNA synthesis was transient and pretreatment with IFN markedly inhibited the ability of GM-CSF, M-CSF, and IL-3 to activate the sodium/hydrogen antiport.	Hydrogen	192-200	interleukin 3	Homo sapiens	164-168
11555638-6	2001	Of most interest is the rearrangement of hydrogen bonding around the breach region that accompanies the stressed to relaxed transition, in particular the formation of a side chain hydrogen bond between the threonine at P14 and an adjacent tyrosine on strand 2 of beta-sheet B in relaxed PAI-2.	Hydrogen	180-188	ribonuclease P/MRP subunit p14	Homo sapiens	219-222
1653702-0	1991	The role of the internal hydrogen bond network in first-order protein electron transfer between Saccharomyces cerevisiae iso-1-cytochrome c and bovine microsomal cytochrome b5.	Hydrogen	25-33	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	121-126
11606240-2	2001	These thermodynamic functions were originally derived to assess the distribution of by-product contaminants in the process condensate and the steam-system deaerator of a hydrogen plant [Paper ENV-00-171 presented at the NPRA 2000 Environmental Conference, San Antonio, TX, 10-12 September 2000], but have general applicability to other systems as well.	Hydrogen	170-178	endogenous retrovirus group K member 20	Homo sapiens	192-195
1653702-1	1991	An internal water molecule (designated WAT166) is found in iso-1-cytochrome c which is part of a redox-state-dependent hydrogen bond network.	Hydrogen	119-127	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	59-64
11473352-9	2001	The loss of the hydrogen bond near the C-terminus appears to facilitate the chiral reversal at Aib(11).	Hydrogen	16-24	ANIB1	Homo sapiens	95-98
1653702-3	1991	Using saturation transfer 1H-NMR methods, this study measures changes in the electron transfer reactivity for three variants of yeast iso-1-cytochromes c in which the position of this water molecule is altered.	Hydrogen	26-28	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	134-139
1856855-1	1991	The presence of bound water molecules in the solution structure of reduced human thioredoxin has been investigated using three-dimensional 1H rotating frame Overhauser 1H-15N multiple quantum coherence spectroscopy.	Hydrogen	139-141	thioredoxin	Homo sapiens	81-92
11570891-1	2001	The 1 equiv reaction between ascorbic acid and cytochrome b(561) is a good model for redox reactions between metalloproteins (electron carriers) and specific organic substrates (hydrogen-atom carriers).	Hydrogen	178-186	mitochondrially encoded cytochrome b	Homo sapiens	47-59
1856855-1	1991	The presence of bound water molecules in the solution structure of reduced human thioredoxin has been investigated using three-dimensional 1H rotating frame Overhauser 1H-15N multiple quantum coherence spectroscopy.	Hydrogen	168-170	thioredoxin	Homo sapiens	81-92
11570891-3	2001	Ferri/ferrocyanide can mediate reduction of DEPC-treated cytochrome b(561) by ascorbic acid, indicating that DEPC-inhibited cytochrome b(561) cannot accept electrons from a hydrogen-atom donor like ascorbate but can still accept electrons from an electron donor like ferrocyanide.	Hydrogen	173-181	mitochondrially encoded cytochrome b	Homo sapiens	124-136
1856855-5	1991	Potential hydrogen bonds to these water molecules are described and a comparison is made to corresponding bound water molecules in the crystal structure of oxidized Escherichia coli thioredoxin.	Hydrogen	10-18	thioredoxin	Homo sapiens	182-193
1856864-7	1991	The deprotonated imidazole ring of His12 (A10) may act as a hydrogen-bond acceptor.	Hydrogen	60-68	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	42-45
11551200-10	2001	Nucleotide binding to PEPCK-Mn2+ was studied by 1H relaxation rate studies, but results were complicated by long dipole-dipole distances and the presence of competing complexes.	Hydrogen	48-50	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	22-27
1680851-8	1991	The low affinity of Im for DAO may be due to a steric repulsion of the hydrogen atoms of Im at C(3) in the active site.	Hydrogen	71-79	D-amino acid oxidase	Homo sapiens	27-30
11476748-8	2001	Basal release of cGMP was increased up to 4-fold by CNP and this increase was reduced (-50%) in presence of L-NNA or HS-142-1 (-68%).	Hydrogen	117-119	natriuretic peptide C	Rattus norvegicus	52-55
1826561-3	1991	To determine which radical center abstracts one of the hydrogen atoms from C-5", the self-complementary oligodeoxynucleotide GCAGCGCTGC was synthesized with 2H at both 5" positions of the T residue and treated with glutathione-activated chromophore.	Hydrogen	55-63	complement C5	Homo sapiens	75-78
11414818-1	2001	Catalysis of (18)O exchange between CO(2) and water catalyzed by a Co(II)-substituted mutant of human carbonic anhydrase II is analyzed to show the rate of release of H(2)(18)O from the active site.	Hydrogen	167-172	carbonic anhydrase 2	Homo sapiens	102-123
11401551-0	2001	Interaction of yeast iso-1-cytochrome c with cytochrome c peroxidase investigated by [15N, 1H] heteronuclear NMR spectroscopy.	Hydrogen	91-93	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	45-68
11401551-2	2001	Chemical shift perturbations for both 15N and 1H nuclei arising from the interaction of isotopically enriched 15N cytochrome c with cytochrome c peroxidase have been observed.	Hydrogen	46-48	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	132-155
1900533-3	1991	The 1H NMR chemical shift of the C-4 hydrogen of pravadoline in comparison to the deshielding seen with 50, which lacks a substituent at C-2, suggested that the carbonyl group of pravadoline is located near C-2 but is located near C-4 in 50.	Hydrogen	4-6	complement component 4B (Chido blood group)	Mus musculus	33-36
1940052-2	1991	Incubation of PU5-1.8 cells in high K(+)-HEPES buffer or with gramicidin at 37 degrees C for 1h that depolarized the membrane induced [3H]-thymidine incorporation and expression of early response gene such as c-myc and c-fos.	Hydrogen	93-95	FBJ osteosarcoma oncogene	Mus musculus	219-224
11352722-10	2001	In the syn structure, a weak A-T hydrogen bond is possible between the N3-H proton of T(17) and N7 of dA(6) (at a distance of 3.11 A), whereas N1, the usual hydrogen bonding partner for N3-H of T when dA is in the anti conformation, is 6.31 A away from this proton.	Hydrogen	33-41	synemin	Homo sapiens	7-10
11352722-10	2001	In the syn structure, a weak A-T hydrogen bond is possible between the N3-H proton of T(17) and N7 of dA(6) (at a distance of 3.11 A), whereas N1, the usual hydrogen bonding partner for N3-H of T when dA is in the anti conformation, is 6.31 A away from this proton.	Hydrogen	157-165	synemin	Homo sapiens	7-10
11356255-3	2001	Stimulation of BAEC with recombinant bovine tumor necrosis factor alpha (rbTNF-alpha) resulted in protein expression of VCAM-1 on less than 5% of all cultured BAECs at 1h post-stimulation, followed by a significant increase at 3h that was maintained until 48h when the proportion of VCAM-1 positive (+) cells decreased significantly, but not to baseline proportions.	Hydrogen	168-170	vascular cell adhesion molecule 1	Bos taurus	120-126
2249695-1	1990	The 1H-NMR spectra of native human epidermal growth factor (EGF) and a derivative lacking the final five residues have been assigned by two-dimensional methods, enabling their structures to be compared.	Hydrogen	4-6	epidermal growth factor	Homo sapiens	35-58
2249695-1	1990	The 1H-NMR spectra of native human epidermal growth factor (EGF) and a derivative lacking the final five residues have been assigned by two-dimensional methods, enabling their structures to be compared.	Hydrogen	4-6	epidermal growth factor	Homo sapiens	60-63
30446439-4	2019	Protein-based 1H NMR experiments indicated that inhibitor 2 rapidly formed a covalent adduct with MGL with a residence time of about 6 h. This interconversion process "intrinsic reversibility" was exploited by modifications of the ligand"s size (length and bulkiness) to generate analogs with "tunable" adduct residence time (tau).	Hydrogen	14-16	monoglyceride lipase	Homo sapiens	98-101
2271620-9	1990	RBG200 DHFR was found to specifically transfer the pro-R hydrogen of NADPH to dihydrofolate, making it a member of the A-stereospecific class of dehydrogenases.	Hydrogen	57-65	dihydrofolate reductase	Homo sapiens	7-11
30907314-9	2019	The expression levels of p- JAK2/JAK2, p-STAT3/STAT3 were upregulated in the hydrogen-rich water group compared with the control group, and p-STAT1/STAT1 was downregulated in the hydrogen-rich water group compared with the control group.	Hydrogen	77-85	Janus kinase 2	Rattus norvegicus	28-32
2271620-10	1990	Thus, although RBG200 DHFR is different both in sequence and in structure from known chromosomal enzymes, both enzymes catalyze identical hydrogen-transfer reactions.	Hydrogen	138-146	dihydrofolate reductase	Homo sapiens	22-26
30907314-9	2019	The expression levels of p- JAK2/JAK2, p-STAT3/STAT3 were upregulated in the hydrogen-rich water group compared with the control group, and p-STAT1/STAT1 was downregulated in the hydrogen-rich water group compared with the control group.	Hydrogen	77-85	Janus kinase 2	Rattus norvegicus	33-37
30907314-11	2019	CONCLUSION: Hydrogen-rich water may inhibit the apoptosis of cardiomyocytes after ischaemia-reperfusion by upregulating the expression of the JAK2-STAT3 signalling pathway, which reduces ischaemia-reperfusion injury.	Hydrogen	12-20	Janus kinase 2	Rattus norvegicus	142-146
2128706-1	1990	The stability of complexes formed by Cd2+ in hemolyzed human erythrocytes was studied by spin-echo 1H NMR spectroscopy.	Hydrogen	99-101	CD2 molecule	Homo sapiens	37-40
2128706-3	1990	A semiquantitative estimate of the overall stability constant for the complexation of Cd2+ in hemolyzed erythrocytes was obtained from spin-echo 1H NMR data.	Hydrogen	145-147	CD2 molecule	Homo sapiens	86-89
31452101-3	2019	In this chapter, we describe the concepts behind the programs used to predict hydrogen bond potential energy employing semi-empirical force fields as the ones available in the programs AMBER, AutoDock4, TreeDock, and ReplicOpter.	Hydrogen	78-86	dedicator of cytokinesis 4	Homo sapiens	192-201
2271572-7	1990	However, the Schiff base C = NH+ stretching frequency and its D2O shift in 7,9-dicis-rhodopsin are very similar to those in 11-cis- and 9-cis-rhodopsin, indicating that the Schiff base electrostatic/hydrogen-bonding environments are effectively the same.	Hydrogen	199-207	rhodopsin	Bos taurus	85-94
30542740-0	2019	Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis.	Hydrogen	0-8	CD8a molecule	Homo sapiens	32-35
30542740-7	2019	Notably, hydrogen gas decreased the abundance of exhausted terminal PD-1+ CD8+ T cells, increased that of active terminal PD-1- CD8+ T cells, and improved PFS and OS times, suggesting that the balance between terminal PD1+ and PD1- CD8+ T cells is critical for cancer prognosis.	Hydrogen	9-17	CD8a molecule	Homo sapiens	74-77
30542740-7	2019	Notably, hydrogen gas decreased the abundance of exhausted terminal PD-1+ CD8+ T cells, increased that of active terminal PD-1- CD8+ T cells, and improved PFS and OS times, suggesting that the balance between terminal PD1+ and PD1- CD8+ T cells is critical for cancer prognosis.	Hydrogen	9-17	CD8a molecule	Homo sapiens	128-131
30542740-7	2019	Notably, hydrogen gas decreased the abundance of exhausted terminal PD-1+ CD8+ T cells, increased that of active terminal PD-1- CD8+ T cells, and improved PFS and OS times, suggesting that the balance between terminal PD1+ and PD1- CD8+ T cells is critical for cancer prognosis.	Hydrogen	9-17	CD8a molecule	Homo sapiens	128-131
30542740-9	2019	Collectively, the present results suggested that hydrogen gas reverses imbalances toward PD-1+ CD8+ T cells to provide an improved prognosis.	Hydrogen	49-57	CD8a molecule	Homo sapiens	95-98
2083276-0	1990	[Myosin head swivel in a muscular contraction model based on an hypothesis on the role of hydrogen bond excitation].	Hydrogen	90-98	myosin heavy chain 14	Homo sapiens	1-7
2083276-1	1990	A theory of muscle contraction developed by the authors in their earlier papers based on the idea of hydrogen-bond attractive force increase under excitation is modified for the model of myosin head swivel.	Hydrogen	101-109	myosin heavy chain 14	Homo sapiens	187-193
2083276-2	1990	The hydrogen bonds are supposed to be located at a hinge or near actin-myosin contact.	Hydrogen	4-12	myosin heavy chain 14	Homo sapiens	71-77
2083276-3	1990	The energy of ATP decay is transferred to the hydrogen bonds whose operation results in myosin head swivel.	Hydrogen	46-54	myosin heavy chain 14	Homo sapiens	88-94
2126460-2	1990	Residue Asn313 is involved together with the carboxyamide moiety of the nicotinamide ring in a complex network of hydrogen bonding interactions which fix the position of the pyridinium ring of NAD to which hydride transfer occurs at the C-4 position in the catalytic reaction.	Hydrogen	114-122	complement C4A (Rodgers blood group)	Homo sapiens	237-240
30444623-7	2018	Other energetically accessible isomers with ground spin states 1/2, 7/2, 9/2, or 11/2 can be obtained through perturbations of hydrogen-bonding networks (e.g., H+ from His337 to O3 or W2), consistent with experimental observations.	Hydrogen	127-135	olfactory receptor family 7 subfamily E member 11 pseudogene	Homo sapiens	56-85
30648951-2	2018	The introduced terminal hydroxy group forms an additional hydrogen bond to Arg274, which is the most important amino acid residue for recognizing the ligand hormone 1alpha,25-dihydroxyvitamin D3 of human VDR.	Hydrogen	58-66	vitamin D receptor	Homo sapiens	204-207
2325552-0	1990	1H NMR observation of tissue myoglobin: an indicator of cellular oxygenation in vivo.	Hydrogen	0-2	myoglobin	Homo sapiens	29-38
30608714-0	2018	Role of Hydrogen in the Spin-Orbital-Entangled Quantum Liquid Candidate H_{3}LiIr_{2}O_{6}.	Hydrogen	8-16	spindlin 1	Homo sapiens	24-28
33779055-7	2021	Docking analysis determined the interaction of compounds ( 1-3 ) and alpha-glucosidase was mainly forced by hydrogen bonds and hydrophobic interaction, which could be effectively inserted into the active pocket of alpha-glucosidase.	Hydrogen	108-116	sucrase-isomaltase	Homo sapiens	69-86
30392906-7	2018	Furthermore, we also found that MPZL1 exists as a homodimer in the crystal, in which hydrogen bonds between Ser86 and Val145 play an important role.	Hydrogen	85-93	myelin protein zero like 1	Homo sapiens	32-37
33779055-7	2021	Docking analysis determined the interaction of compounds ( 1-3 ) and alpha-glucosidase was mainly forced by hydrogen bonds and hydrophobic interaction, which could be effectively inserted into the active pocket of alpha-glucosidase.	Hydrogen	108-116	sucrase-isomaltase	Homo sapiens	214-231
33821640-6	2021	The esters inhibited tyrosinase by making the secondary structure of tyrosinase looser and less stable; moreover, the interactions between tyrosinase and AU driven by metal interactions and hydrogen bonds also offered a mechanism for inhibition of AU on tyrosinase.	Hydrogen	190-198	tyrosinase	Mus musculus	21-31
29896909-4	2018	Immunoblotting was used to measure levels of H2 S-synthesizing enzymes: cystathionine-beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulphurtransferase (MPST).	Hydrogen	45-47	cystathionine gamma-lyase	Homo sapiens	134-137
33821640-6	2021	The esters inhibited tyrosinase by making the secondary structure of tyrosinase looser and less stable; moreover, the interactions between tyrosinase and AU driven by metal interactions and hydrogen bonds also offered a mechanism for inhibition of AU on tyrosinase.	Hydrogen	190-198	tyrosinase	Mus musculus	69-79
29271265-4	2018	Compound 1h, the most promising multifunctional anti-AD agent, had IC50 of 56 nM against PDE9A and good antioxidant ability (ORAC (trolox) = 3.3).	Hydrogen	9-11	phosphodiesterase 9A	Homo sapiens	89-94
33821640-6	2021	The esters inhibited tyrosinase by making the secondary structure of tyrosinase looser and less stable; moreover, the interactions between tyrosinase and AU driven by metal interactions and hydrogen bonds also offered a mechanism for inhibition of AU on tyrosinase.	Hydrogen	190-198	tyrosinase	Mus musculus	69-79
33821640-6	2021	The esters inhibited tyrosinase by making the secondary structure of tyrosinase looser and less stable; moreover, the interactions between tyrosinase and AU driven by metal interactions and hydrogen bonds also offered a mechanism for inhibition of AU on tyrosinase.	Hydrogen	190-198	tyrosinase	Mus musculus	69-79
33780628-6	2021	Experimental and computational studies suggested that the putative triplet Co nitrenoids are transferred to the C-H bonds of alkanes via a radical-like hydrogen abstraction pathway.	Hydrogen	152-160	ceruloplasmin	Homo sapiens	75-76
33767697-0	2021	Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue Factor Expression.	Hydrogen	0-8	thioredoxin	Homo sapiens	64-77
33767697-0	2021	Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue Factor Expression.	Hydrogen	0-8	coagulation factor III, tissue factor	Homo sapiens	93-106
33767697-10	2021	LPS-stimulated THP-1 and HUVEC-C cells in vitro and showed that hydrogen decreases TF expression and MMP-9 activity, which were abolished by the Trx1 inhibitor, PX12.	Hydrogen	64-72	coagulation factor III, tissue factor	Homo sapiens	83-85
33767697-10	2021	LPS-stimulated THP-1 and HUVEC-C cells in vitro and showed that hydrogen decreases TF expression and MMP-9 activity, which were abolished by the Trx1 inhibitor, PX12.	Hydrogen	64-72	thioredoxin	Homo sapiens	145-149
33767697-11	2021	Hydrogen attenuates endotoxin-induced lung injury by decreasing TF expression and MMP-9 activity via activating Trx1.	Hydrogen	0-8	coagulation factor III, tissue factor	Homo sapiens	64-66
33767697-11	2021	Hydrogen attenuates endotoxin-induced lung injury by decreasing TF expression and MMP-9 activity via activating Trx1.	Hydrogen	0-8	thioredoxin	Homo sapiens	112-116
33767697-12	2021	Targeting Trx1 by hydrogen may be a potential treatment for endotoxin-induced lung injury.	Hydrogen	18-26	thioredoxin	Homo sapiens	10-14
33587625-3	2021	In the case of half of the hydrogen bonds, a phase transition from AP to the first high-pressure phase (HP1) at ~1.2 GPa resulted in an increase in the H-H distances, which suggested that the dihydrogen bonds were broken.	Hydrogen	27-35	defensin alpha 1	Homo sapiens	104-107
33590691-7	2021	Density functional theory calculations find that redistribution of charges at the heterointerface can reduce hydrogen adsorption Gibbs free energy ( GH* ) and water decomposition energy barrier.	Hydrogen	109-117	gamma-glutamyl hydrolase	Homo sapiens	149-152
25698576-7	2015	On the other hand, 26 top scoring hits were identified against the ligandable region at the A1 ARF6 interface which showed strong hydrogen bonding interactions, including guanidines, phosphates, Leucopterin and Aristolochic acid VIa.	Hydrogen	130-138	ADP ribosylation factor 6	Homo sapiens	95-99
11316888-0	2001	Amide hydrogen exchange shows that malate dehydrogenase is a folded monomer at pH 5.	Hydrogen	6-14	malic enzyme 1	Homo sapiens	35-55
11316888-2	2001	The present amide hydrogen exchange study was performed to determine whether MDH remains a dimer at pH 5.	Hydrogen	18-26	malic enzyme 1	Homo sapiens	77-80
11316888-5	2001	In parallel experiments, elevated deuterium levels were also found in the same regions of MDH monomer trapped inside a mutant form of the chaperonin GROEL: This selective increase in hydrogen exchange rates, which was attributed to increased solvent accessibility of these regions, provides new evidence that MDH is a monomer at pH 5.	Hydrogen	183-191	malic enzyme 1	Homo sapiens	90-93
11316888-5	2001	In parallel experiments, elevated deuterium levels were also found in the same regions of MDH monomer trapped inside a mutant form of the chaperonin GROEL: This selective increase in hydrogen exchange rates, which was attributed to increased solvent accessibility of these regions, provides new evidence that MDH is a monomer at pH 5.	Hydrogen	183-191	malic enzyme 1	Homo sapiens	309-312
34942455-3	2022	Characterization results revealed that SLP-AgNPs were uniformly surrounded by protein corona provided from SLP, and the formulations were mainly mediated by the electrostatic interactions and hydrogen bonding, which was evidenced by the results of Fourier transform infrared spectroscopy.	Hydrogen	192-200	Slp	Staphylococcus aureus	39-42
11262101-5	2001	The rotational rate and syn/anti ratio, which indicate the orientation between carbonyl oxygen and hydrogen at the 4-position, are significantly affected by addition of magnesium ion.	Hydrogen	99-107	synemin	Homo sapiens	24-27
34915246-4	2022	The mechanism of CAL-B reducing metal ions was investigated, revealing that AGLFFSSKDL in the amino acid sequence of CAL-B from 111 to 128 formed a stable spatial structure through hydrogen bonding, which was the key factor for enzyme in situ reduction of metal ions into highly dispersed nanoparticles.	Hydrogen	181-189	calbindin 1	Homo sapiens	17-22
11327810-8	2001	NOESY spectra of 1 and 2 recorded in 95% H(2)O, 5% D(2)O indicated that the imino proton of the base opposite N14, G5, or T5, formed a weak hydrogen bond with N14.	Hydrogen	140-148	SS nuclear autoantigen 1	Homo sapiens	110-113
11327810-8	2001	NOESY spectra of 1 and 2 recorded in 95% H(2)O, 5% D(2)O indicated that the imino proton of the base opposite N14, G5, or T5, formed a weak hydrogen bond with N14.	Hydrogen	140-148	SS nuclear autoantigen 1	Homo sapiens	159-162
34915246-4	2022	The mechanism of CAL-B reducing metal ions was investigated, revealing that AGLFFSSKDL in the amino acid sequence of CAL-B from 111 to 128 formed a stable spatial structure through hydrogen bonding, which was the key factor for enzyme in situ reduction of metal ions into highly dispersed nanoparticles.	Hydrogen	181-189	calbindin 1	Homo sapiens	117-122
11209600-15	2001	These two complexes have a significant population of the anti, syn delta HT1 conformer, as indicated by broad 1H NMR signals and by 31P NMR and CD data.	Hydrogen	110-112	synemin	Homo sapiens	63-66
34626963-0	2022	A cation exchange strategy to construct Rod-shell CdS/Cu2S nanostructures for broad spectrum photocatalytic hydrogen production.	Hydrogen	108-116	CDP-diacylglycerol synthase 1	Homo sapiens	50-53
11206437-2	2001	Replacement of the amide moiety by other groups containing internal hydrogen bonds was undertaken to extend the SAR.	Hydrogen	68-76	sarcosine dehydrogenase	Homo sapiens	112-115
34626963-4	2022	The obtained CdS/Cu2S rod-shell NRs exhibit much enhanced activity of hydrogen production (640.95 mumol h-1 g-1) in comparison with pure CdS NRs (74.1 mumol h-1 g-1) and pure Cu2S NRs (0 mumol h-1 g-1).	Hydrogen	70-78	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
34952337-5	2022	Our simulations showed loaded DOXs on the APO-Fr surface were mainly involved in the hydrogen bond interactions with the hydrophilic residues, suggesting the difficulty of hydrophobic drugs loading in APO-Fr with the partial disassembly process.	Hydrogen	85-93	ferritin heavy chain 1	Homo sapiens	42-48
11380187-4	2001	The rate and extent of RDX degradation in microcosms was enhanced by anaerobic bacteria that feed on cathodic hydrogen (i.e., H2 produced during anaerobic Fe(0) corrosion by water).	Hydrogen	110-118	radixin	Homo sapiens	23-26
34952337-5	2022	Our simulations showed loaded DOXs on the APO-Fr surface were mainly involved in the hydrogen bond interactions with the hydrophilic residues, suggesting the difficulty of hydrophobic drugs loading in APO-Fr with the partial disassembly process.	Hydrogen	85-93	ferritin heavy chain 1	Homo sapiens	201-207
11380187-4	2001	The rate and extent of RDX degradation in microcosms was enhanced by anaerobic bacteria that feed on cathodic hydrogen (i.e., H2 produced during anaerobic Fe(0) corrosion by water).	Hydrogen	126-128	radixin	Homo sapiens	23-26
34309842-9	2022	The molecular docking results showed that two peptides could bind angiotensin-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) tightly by hydrogen bonding and hydrophobic interaction.	Hydrogen	150-158	dipeptidyl peptidase 4	Homo sapiens	106-129
11140638-6	2000	Our results show that the N-terminal four residues (Ala-Val-Pro-Ile) in Smac/DIABLO recognize a surface groove on BIR3, with the first residue Ala binding a hydrophobic pocket and making five hydrogen bonds to neighbouring residues on BIR3.	Hydrogen	192-200	diablo	Drosophila melanogaster	72-76
34309842-9	2022	The molecular docking results showed that two peptides could bind angiotensin-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) tightly by hydrogen bonding and hydrophobic interaction.	Hydrogen	150-158	dipeptidyl peptidase 4	Homo sapiens	131-137
11140638-6	2000	Our results show that the N-terminal four residues (Ala-Val-Pro-Ile) in Smac/DIABLO recognize a surface groove on BIR3, with the first residue Ala binding a hydrophobic pocket and making five hydrogen bonds to neighbouring residues on BIR3.	Hydrogen	192-200	diablo	Drosophila melanogaster	77-83
34599772-6	2022	Furthermore, the design of distributing bulk Zn in a 3D microscale manner suppresses hydrogen evolution reactions (3.8 mmol h-1 cm-2 ) and passivation through in/ex-situ tests.	Hydrogen	85-93	H1.5 linker histone, cluster member	Homo sapiens	124-132
11352470-3	2000	The reduced PBI interacts with the DNA major groove at AT base pairs by forming Hoogsteen-like hydrogen bonds.	Hydrogen	95-103	submaxillary gland androgen regulated protein 3A	Homo sapiens	12-15
11352470-4	2000	The reduced 3-amino PBI forms three hydrogen bonds in the major groove with the amino group acting as an H-bond donor to the thymine carbonyl.	Hydrogen	36-44	submaxillary gland androgen regulated protein 3A	Homo sapiens	20-23
10952992-4	2000	Critical to family selective dimerization are intersubunit hydrogen bonds between basic region residue Tyr(307) and leucine zipper residue Glu(312), which are conserved in all CREB/CREM/ATF-1 family members.	Hydrogen	59-67	cAMP responsive element binding protein 1	Homo sapiens	176-180
10952992-4	2000	Critical to family selective dimerization are intersubunit hydrogen bonds between basic region residue Tyr(307) and leucine zipper residue Glu(312), which are conserved in all CREB/CREM/ATF-1 family members.	Hydrogen	59-67	cAMP responsive element modulator	Homo sapiens	181-185
34911387-2	2022	We have overcome the challenges in using ATR FT-IR as the downstream analytical methods imposed when a large amount of hydrogen gas is produced from the counter electrode by designing two types of gas-liquid separators (GLS) for analysis of the product mixture flowing from the electrochemical reactor.	Hydrogen	119-127	gastrin	Homo sapiens	128-131
11027132-10	2000	ZK-807834 forms a strong hydrogen bond between an ionized 2-hydroxy group and Ser195 of factor Xa.	Hydrogen	25-33	coagulation factor X	Homo sapiens	88-97
34966948-6	2021	Molecular dynamics studies revealed that NF-alpha1/CPE interacts with 5-HTR1E via 3 salt bridges, stabilized by several hydrogen bonds, independent of the serotonin pocket.	Hydrogen	120-128	POU class 2 homeobox 1	Homo sapiens	41-50
11045643-3	2000	In the GvHD model, ACI (RT1a) donors were pretreated (day -14) with an intrathymic injection of alpha(1h)l58-80-RT1.Aa, alpha(1h)l/u62-69-RT1.Aa, or RT1.Al protein, with or without simultaneous intravenous injection of anti-T-cell receptor R73 monoclonal antibodies.	Hydrogen	102-104	RT1 class I, locus A	Rattus norvegicus	112-118
11051090-10	2000	Other enzymes whose mechanisms appear to involve low-barrier hydrogen bonds include liver alcohol dehydrogenase, steroid isomerase, triose-P isomerase, aconitase, citrate synthase, and zinc proteases.	Hydrogen	61-69	aldo-keto reductase family 1 member A1	Homo sapiens	90-111
34966948-6	2021	Molecular dynamics studies revealed that NF-alpha1/CPE interacts with 5-HTR1E via 3 salt bridges, stabilized by several hydrogen bonds, independent of the serotonin pocket.	Hydrogen	120-128	carboxypeptidase E	Homo sapiens	51-54
34966948-7	2021	Furthermore, after phosphorylating the C-terminal tail and intracellular loop 3 (ICL3) of NF-alpha1/CPE-5-HTR1E, it recruited beta-arrestin1 by forming numerous salt bridges and hydrogen bonds to ICL2 and ICL3, leading to activation of beta-arrestin1.	Hydrogen	178-186	POU class 2 homeobox 1	Homo sapiens	90-99
34874153-6	2021	The final product of the phosgene-mediated reaction, Ru-1-Phos, contains 2-imidazolidinone groups, which has been confirmed by electrospray ionization mass spectometry and 1H nuclear magnetic resonance (NMR) spectroscopy.	Hydrogen	172-174	Scm like with four mbt domains 1	Homo sapiens	53-57
11098404-0	2000	1H-13C nuclear magnetic resonance assignment and structural characterization of HIV-1 Tat protein.	Hydrogen	0-2	Tat	Human immunodeficiency virus 1	86-89
30411104-2	2018	Herein, by utilizing hollow-shell-structured silica, hydrogen-bonding immobilization via a ship-in-a-bottle synthesis locks a Pd(carbene) center in a nanocage and covalent-bonding immobilization tethers chiral Ru(diamine) centers within the nanochannels, constructing a hetero-bifunctional catalyst.	Hydrogen	53-61	inositol polyphosphate-5-phosphatase D	Homo sapiens	91-95
34874153-7	2021	1H NMR titration of Ru-1 with phosgene supported the reaction mechanism and also pointed to the simultaneous reaction of phosgene at two 2-aminoethylamino sites.	Hydrogen	0-2	Scm like with four mbt domains 1	Homo sapiens	20-24
34859998-5	2021	Interestingly, the flexural strength and modulus were greatly enhanced from 72.8 MPa and 1.3 GPa to 90.3 MPa and 2.8 GPa, respectively, at 30 wt % MEP, due to the rigidity of MEP and strong intermolecular N-H hydrogen bonding interactions.	Hydrogen	209-217	neurolysin	Homo sapiens	147-150
11089640-7	2000	When pH is elevated or under the action of activated RecA, cleavage may occur following a cis --&gt; trans isomerization at Pro 87 and/or a rotation of the region beta9-beta10 about beta7-beta8 following the disruption of two hydrogen bonds.	Hydrogen	226-234	RAD51 recombinase	Homo sapiens	53-57
30412406-3	2018	Under acidic conditions, the hydrolysis rates of MES were enhanced by micellar formation and correlated quantitatively with the amount of protons bound on the micellar surfaces being measured by the electric conductivity along with fluorescence and hydrogen-ion electrode measurements.	Hydrogen	249-257	MKS transition zone complex subunit 1	Homo sapiens	49-52
10966919-1	2000	The activity of the sodium/hydrogen exchanger 3 (NHE3) isoform of the sodium/hydrogen exchanger in the brush-border membrane of the renal proximal tubule is tightly regulated.	Hydrogen	27-35	solute carrier family 9 member A3	Homo sapiens	49-53
34859998-5	2021	Interestingly, the flexural strength and modulus were greatly enhanced from 72.8 MPa and 1.3 GPa to 90.3 MPa and 2.8 GPa, respectively, at 30 wt % MEP, due to the rigidity of MEP and strong intermolecular N-H hydrogen bonding interactions.	Hydrogen	209-217	neurolysin	Homo sapiens	175-178
10966919-1	2000	The activity of the sodium/hydrogen exchanger 3 (NHE3) isoform of the sodium/hydrogen exchanger in the brush-border membrane of the renal proximal tubule is tightly regulated.	Hydrogen	77-85	solute carrier family 9 member A3	Homo sapiens	49-53
34627044-7	2021	Molecular docking simulation indicated the binding potency of bisphenol analogues to PPARbeta/delta might depend on halogenation and hydrophobicity and the transcriptional activity might depend on their binding affinity and hydrogen bond interactions.	Hydrogen	224-232	peroxisome proliferator activated receptor alpha	Homo sapiens	85-93
34944028-9	2021	Experiments performed by quenching assay, docking, and Thioflavin T assay further established that the main forces are hydrogen Van der Waals and some non-negligible hydrophobic forces, affecting the lag phase of tau protein kinetics.	Hydrogen	119-127	microtubule associated protein tau	Homo sapiens	213-216
10946229-4	2000	Crystal structures of AAG complexed to DNA suggest that the enzyme selects substrate bases through a combination of hydrogen bonding and the steric constraints of the active site, and that the enzyme activates a water molecule for an in-line backside attack of the N-glycosylic bond.	Hydrogen	116-124	N-methylpurine DNA glycosylase	Homo sapiens	22-25
34883530-6	2022	Remarkably, despite featuring identical parameters in chemical microenvironment and support in M1 /SnO2 /UiO-66-NH2 , the Pt1 catalyst possesses a hydrogen evolution rate of 2167 mumol g-1  h-1 , superior to the Cu1 and Ni1 counterparts, which is attributed to the differentiated hydrogen binding free energies, as supported by density-functional theory (DFT) calculations.	Hydrogen	147-155	zinc finger protein 77	Homo sapiens	122-125
10952131-3	2000	Based on enthalpy and volume differences between the conformers, these bands are assigned to the syn conformer which has hydrogen bonds between the fluorine atom and water molecules (syn" conformer).	Hydrogen	121-129	synemin	Homo sapiens	97-100
10952131-3	2000	Based on enthalpy and volume differences between the conformers, these bands are assigned to the syn conformer which has hydrogen bonds between the fluorine atom and water molecules (syn" conformer).	Hydrogen	121-129	synemin	Homo sapiens	183-186
34883530-6	2022	Remarkably, despite featuring identical parameters in chemical microenvironment and support in M1 /SnO2 /UiO-66-NH2 , the Pt1 catalyst possesses a hydrogen evolution rate of 2167 mumol g-1  h-1 , superior to the Cu1 and Ni1 counterparts, which is attributed to the differentiated hydrogen binding free energies, as supported by density-functional theory (DFT) calculations.	Hydrogen	280-288	zinc finger protein 77	Homo sapiens	122-125
10864765-3	2000	This change of mechanism was justified on the basis of the syn and anti rotational conformers of the diene -N((1))=C-C=N((2))- group; the greater stability of the former can be explained by the formation of hydrogen bonds between the proton and the N((1)) and N((2)) nitrogen atoms, giving rise to a very stable five-membered ring.	Hydrogen	207-215	synemin	Homo sapiens	59-62
34596317-3	2021	Remarkably, the electrocatalyst yields ethanol, acetone and n-butanol as major products with a total C 2-4 faradaic efficiency of about 49% at -0.8 V vs. reversible hydrogen electrode (RHE), which can be maintained for at least 3 months.	Hydrogen	165-173	complement C2	Homo sapiens	101-106
10915551-0	2000	Evidence for a 1,2 Shift of a Hydrogen Atom in a Radical Intermediate of the Methylmalonyl-CoA Mutase Reaction.	Hydrogen	30-38	methylmalonyl-CoA mutase	Homo sapiens	77-101
10915551-2	2000	After addition of highly purified epimerase-free methylmalonyl-CoA mutase the enzymatic rearrangement was monitored by 1H NMR spectroscopy.	Hydrogen	119-121	methylmalonyl-CoA mutase	Homo sapiens	49-73
12526516-6	2000	Complexes 1-PdCl2 and 2-PdCl2, which contain an NH group, exhibit both intermolecular and intramolecular hydrogen bonding, whereas isomers 3-PdCl2 and 4-PdCl2 do not.	Hydrogen	105-113	phosducin like 2	Homo sapiens	12-17
12526516-6	2000	Complexes 1-PdCl2 and 2-PdCl2, which contain an NH group, exhibit both intermolecular and intramolecular hydrogen bonding, whereas isomers 3-PdCl2 and 4-PdCl2 do not.	Hydrogen	105-113	phosducin like 2	Homo sapiens	24-29
34348129-5	2021	Here we describe the rapid and efficient characterization of multiple PI3Kgamma binding single-chain camelid nanobodies using hydrogen-deuterium exchange (HDX) mass spectrometry (MS) for structural and biochemical studies.	Hydrogen	126-134	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	70-79
12526516-6	2000	Complexes 1-PdCl2 and 2-PdCl2, which contain an NH group, exhibit both intermolecular and intramolecular hydrogen bonding, whereas isomers 3-PdCl2 and 4-PdCl2 do not.	Hydrogen	105-113	phosducin like 2	Homo sapiens	24-29
12526516-6	2000	Complexes 1-PdCl2 and 2-PdCl2, which contain an NH group, exhibit both intermolecular and intramolecular hydrogen bonding, whereas isomers 3-PdCl2 and 4-PdCl2 do not.	Hydrogen	105-113	phosducin like 2	Homo sapiens	24-29
34570370-0	2021	Competition between inter and intramolecular hydrogen bond evidenced by vibrational circular dichroism spectroscopy: The case of (1S,2R)-(-)-cis-1-amino-2-indanol.	Hydrogen	45-53	suppressor of cytokine signaling 1	Homo sapiens	141-146
10990690-0	2000	Modeling hot, dense hydrogen with a classical spin dependent hamiltonian Hot, dense hydrogen is studied with a classical model in which the interaction energy between atoms depends on their internal spins as well as their separation distance.	Hydrogen	20-28	alcohol dehydrogenase iron containing 1	Homo sapiens	9-12
10990690-0	2000	Modeling hot, dense hydrogen with a classical spin dependent hamiltonian Hot, dense hydrogen is studied with a classical model in which the interaction energy between atoms depends on their internal spins as well as their separation distance.	Hydrogen	20-28	alcohol dehydrogenase iron containing 1	Homo sapiens	73-76
10990690-0	2000	Modeling hot, dense hydrogen with a classical spin dependent hamiltonian Hot, dense hydrogen is studied with a classical model in which the interaction energy between atoms depends on their internal spins as well as their separation distance.	Hydrogen	84-92	alcohol dehydrogenase iron containing 1	Homo sapiens	9-12
10990690-0	2000	Modeling hot, dense hydrogen with a classical spin dependent hamiltonian Hot, dense hydrogen is studied with a classical model in which the interaction energy between atoms depends on their internal spins as well as their separation distance.	Hydrogen	84-92	alcohol dehydrogenase iron containing 1	Homo sapiens	73-76
34570370-1	2021	The infrared (IR) absorption and vibrational circular dichroism (VCD) spectra of an intramolecularly hydrogen-bonded chiral amino-alcohol, (1S,2R)-(-)-cis-1-amino-2-indanol, are studied in DMSO-d6 .	Hydrogen	101-109	suppressor of cytokine signaling 1	Homo sapiens	151-156
34519225-6	2021	Characterization techniques involving 1H-NMR, FT-IR, DSC, PXRD, and molecular docking confirmed the most stable binding interactions when Frax complexed with 6-O-alpha-D-maltosyl-beta-cyclodextrin (G2-beta-CD-Frax).	Hydrogen	38-40	adrenocortical dysplasia	Mus musculus	201-208
11428118-5	2000	Crystallization of 1-OTf in the presence of water affords a colorless high-spin complex, Fe(Me3tacn)(H2O)(CF3-SO3)2 (4), that exists as a pair of molecules bridged by hydrogen bonds between the coordinated water and the two bound triflate anions of the inversion-related partner.	Hydrogen	167-175	spindlin 1	Homo sapiens	75-79
34925297-4	2021	The results revealed that these mutations significantly affected the binding of NSP13 and TBK1 by altering the hydrogen bonding network and dynamic structural features.	Hydrogen	111-119	TANK binding kinase 1	Homo sapiens	90-94
10757973-4	2000	Hydrogen exchange in GroEL destabilized in 1.8 M GdHCl (the unfolding midpoint is 1.2 M GdHCl) shows that the apical and intermediate domains unfold 3.1 times faster than the equatorial domain.	Hydrogen	0-8	heat shock protein family D (Hsp60) member 1	Homo sapiens	21-26
34759385-4	2021	These tridentate hydrogen bond donors are highly effective phase-transfer catalysts for solubilizing safe and inexpensive metal alkali fluorides (KF and CsF) in organic solvents for enantioselective nucleophilic fluorinations.	Hydrogen	17-25	colony stimulating factor 2	Homo sapiens	153-156
10734199-5	2000	Our results show that in spite of its stable hydrogen bonding, the insertion of a T residue opposite the 3"-T of the cis - syn dimer is inhibited by structural distortion caused by the 3"-T x T base pair.	Hydrogen	45-53	synemin	Homo sapiens	123-126
34947607-5	2021	It exhibits particularly high activity of hydrogen generation with the optimal hydrogen production rate of 11086.4 mLH2 min-1 gCo-1 and low activation energy (Ea) of 31.25 kJ mol-1.	Hydrogen	42-50	LIM homeobox protein 2	Mus musculus	115-119
10733977-2	2000	At the central basepair step of the TATA box TBP produces a noticeable decrease in twist and an increase in roll, while engaging in hydrogen bonds with the bases and sugars.	Hydrogen	132-140	TATA-box binding protein	Homo sapiens	45-48
10733977-5	2000	The Asn, Thr, and Gly residues involved in hydrogen bonding to the DNA bases and sugar oxygens form a relatively rigid motif in TBP.	Hydrogen	43-51	TATA-box binding protein	Homo sapiens	128-131
34947607-5	2021	It exhibits particularly high activity of hydrogen generation with the optimal hydrogen production rate of 11086.4 mLH2 min-1 gCo-1 and low activation energy (Ea) of 31.25 kJ mol-1.	Hydrogen	79-87	LIM homeobox protein 2	Mus musculus	115-119
10692339-1	2000	A mutant of a beta-barrel protein, rat intestinal fatty acid binding protein, was predicted to be more stable than the wild-type protein due to a novel hydrogen bond.	Hydrogen	152-160	amyloid beta precursor protein	Rattus norvegicus	12-18
34747964-7	2021	Molecular docking analysis suggested the key role of the amino residues Asp168, Leu178, Asn157, and Ile262 in blocking T2R14, and revealed that the amino acid residues of T2R14 bound with the peptide QRPR via electrostatic interaction, hydrophobic interaction, conventional hydrogen bond, and hydrogen bond.	Hydrogen	274-282	taste 2 receptor member 14	Homo sapiens	171-176
10716178-5	2000	The BPTI molecules have a uniformly distributed positively charged surface that interacts extensively through 14 hydrogen bonds and two hydrogen bonded salt bridges with the helical groove around the helical TAP chains.	Hydrogen	113-121	spleen trypsin inhibitor I	Bos taurus	4-8
10716178-5	2000	The BPTI molecules have a uniformly distributed positively charged surface that interacts extensively through 14 hydrogen bonds and two hydrogen bonded salt bridges with the helical groove around the helical TAP chains.	Hydrogen	136-144	spleen trypsin inhibitor I	Bos taurus	4-8
34747964-7	2021	Molecular docking analysis suggested the key role of the amino residues Asp168, Leu178, Asn157, and Ile262 in blocking T2R14, and revealed that the amino acid residues of T2R14 bound with the peptide QRPR via electrostatic interaction, hydrophobic interaction, conventional hydrogen bond, and hydrogen bond.	Hydrogen	293-301	taste 2 receptor member 14	Homo sapiens	171-176
34899321-7	2021	The hydrogen bond analysis showed that R90, W115, and R116 form stable hydrogen bonds with PGAM1 inhibitors.	Hydrogen	4-12	phosphoglycerate mutase 1	Homo sapiens	91-96
10656386-9	2000	The mean SF2 for each of the NS and the HS groups were 0.31 and 0.17, respectively.	Hydrogen	40-42	serine and arginine rich splicing factor 1	Homo sapiens	9-12
11074157-3	2000	In experiments reported here, transient (1h) exposure of hippocampal explant cultures to kainic acid produced marked focal swellings of the dendrites of parvalbumin-immunoreactive pyramidal basket cells in a highly reproducible and dose-dependent manner.	Hydrogen	41-43	parvalbumin	Homo sapiens	153-164
34899321-7	2021	The hydrogen bond analysis showed that R90, W115, and R116 form stable hydrogen bonds with PGAM1 inhibitors.	Hydrogen	71-79	phosphoglycerate mutase 1	Homo sapiens	91-96
34738466-5	2021	Here, we demonstrate that the small energy difference between the diastereomeric isotopomers at the molecular level can be enhanced to appear as a solubility difference between the diastereomeric (2H/1H) isotopomers of alpha-aminonitriles, synthesized from an isotopically chiral amine, achiral aldehyde, and HCN.	Hydrogen	200-202	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	309-312
11256749-6	2000	The allotype specificity of KIR2DL2 for HLA-Cw3 is the result of a single hydrogen bond from Lys44 of the KIR to Asn80 of HLA-C as all other HLA-C residues that contact KIR are conserved.	Hydrogen	74-82	major histocompatibility complex, class I, C	Homo sapiens	40-45
11256749-6	2000	The allotype specificity of KIR2DL2 for HLA-Cw3 is the result of a single hydrogen bond from Lys44 of the KIR to Asn80 of HLA-C as all other HLA-C residues that contact KIR are conserved.	Hydrogen	74-82	major histocompatibility complex, class I, C	Homo sapiens	122-127
34869093-10	2021	Hydrogen inhibited the NF-kappaB p65 in M1 macrophages nucleus and distal ileum of NEC.	Hydrogen	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	33-36
10603301-9	1999	Further, an NMR study revealed that the reorganization of hydrogen-bond network in the L-PGDS was observed in the presence of 0.5 M GdnHCl.	Hydrogen	58-66	prostaglandin D2 synthase (brain)	Mus musculus	87-93
30453672-1	2018	Glutathione peroxidase 1 (GPX1) is an extensively studied selenium-dependent protein that reduces hydrogen and lipid peroxides to water.	Hydrogen	98-106	glutathione peroxidase 1	Homo sapiens	0-24
30453672-1	2018	Glutathione peroxidase 1 (GPX1) is an extensively studied selenium-dependent protein that reduces hydrogen and lipid peroxides to water.	Hydrogen	98-106	glutathione peroxidase 1	Homo sapiens	26-30
34816264-3	2021	Analysis of the 2.14 A resolution crystal structure of 3CLpro C145S bound to NEMO 226-235 reveals subsites that tolerate a range of viral and host substrates through main chain hydrogen bonds while also enforcing specificity using side chain hydrogen bonds and hydrophobic contacts.	Hydrogen	177-185	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	77-81
30359035-1	2018	Soybean lipoxygenase catalyzes a proton-coupled electron transfer (PCET) reaction and serves as a prototype for hydrogen tunneling in enzymes due to the unusually high kinetic isotope effect and significant modulation of the rate constant and kinetic isotope effect by mutation.	Hydrogen	112-120	linoleate 9S-lipoxygenase-4	Glycine max	8-20
30429524-0	2018	Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice.	Hydrogen	18-26	low density lipoprotein receptor	Mus musculus	78-90
30357171-2	2018	The reaction can proceed by abstraction of either the terminal hydrogen atom of OOH group producing CH3O, O2 and H2O, or one hydrogen atom of the CH3 group forming H2CO, HO2 and H2O.	Hydrogen	63-71	EBP cholestenol delta-isomerase	Homo sapiens	100-108
10600384-8	1999	In contrast to serine 29 of profilin I, tyrosine 29 in profilin II is capable of forming an additional stacking interaction and a hydrogen bond with poly-L-proline which may account for the increased affinity of the second isoform for proline-rich peptides.	Hydrogen	130-138	profilin 2	Homo sapiens	55-66
10570254-5	1999	At the opening of the pocket, a hydrogen bond network may render Sec14p the binding specificity to PI molecules.	Hydrogen	32-40	phosphatidylinositol/phosphatidylcholine transfer protein SEC14	Saccharomyces cerevisiae S288C	65-71
10610769-6	1999	Although G9 and C11 are paired through hydrogen bonds of Watson-Crick type, the base-pair is not planar but rather adopts a wedge-shaped geometry with the two bases stacked on top of each other in the minor groove.	Hydrogen	39-47	aldo-keto reductase family 1 member C4	Homo sapiens	16-19
34816264-3	2021	Analysis of the 2.14 A resolution crystal structure of 3CLpro C145S bound to NEMO 226-235 reveals subsites that tolerate a range of viral and host substrates through main chain hydrogen bonds while also enforcing specificity using side chain hydrogen bonds and hydrophobic contacts.	Hydrogen	242-250	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	77-81
34746315-11	2021	Finally, cytokine assays showed that IL-2 and IL-10 levels significantly differed between the hydrogen-treated and nontreated groups.	Hydrogen	94-102	interleukin 2	Mus musculus	37-41
29048995-4	2018	Free energy decomposition method was applied to study the contributions of individual residues to inhibitor bindings, it is found that three inhibitors can generate hydrogen bonding interactions and hydrophobic interactions with different residues of PTP1B, which provide important forces for associations of inhibitors with PTP1B.	Hydrogen	165-173	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	251-256
34746315-13	2021	Hydrogen treatment also decreased Bax and TNFalpha levels and induced an anti-inflammatory response via regulation of IL-2 and IL-10.	Hydrogen	0-8	interleukin 2	Mus musculus	118-122
29048995-4	2018	Free energy decomposition method was applied to study the contributions of individual residues to inhibitor bindings, it is found that three inhibitors can generate hydrogen bonding interactions and hydrophobic interactions with different residues of PTP1B, which provide important forces for associations of inhibitors with PTP1B.	Hydrogen	165-173	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	325-330
34661231-0	2021	Finding the catalytically active sites on the layered tri-chalcogenide compounds CoPS3 and NiPS3 for hydrogen evolution reaction.	Hydrogen	101-109	COP9 signalosome subunit 3	Homo sapiens	81-86
30167931-8	2018	Some structural features are highly conserved in the two isozymes, such as a Tyr-Tyr aromatic sandwich in front of the flavin ring and a Lys residue hydrogen-bonded to the cofactor N5 atom, whereas a pair of gating residues (Phe208/Ile335 in MAO A; Ile199/Tyr326 in MAO B) specifically determines the different substrate and inhibitor properties of the two enzymes.	Hydrogen	149-157	monoamine oxidase B	Homo sapiens	266-271
10543977-0	1999	Unfolding and refolding of bovine beta-lactoglobulin monitored by hydrogen exchange measurements.	Hydrogen	66-74	beta-lactoglobulin	Bos taurus	34-52
10531390-8	1999	Three-dimensional models built on the basis of the predicted structure of rhodopsin showed that Tyr(308) of the beta(2)AR covered the binding pocket formed by TM2 and TM7 from the upper side, and Thr(117) of the beta(1)AR located in the middle of the binding pocket to provide a hydrogen bonding for the beta(1)-selective agonists.	Hydrogen	279-287	adrenoceptor beta 2	Homo sapiens	112-121
34661231-1	2021	Electronic structure calculations based on density functional theory are used to identify the catalytically active sites for the hydrogen evolution reaction on single layers of the two transition metal tri-chalcogenide compounds CoPS3 and NiPS3.	Hydrogen	129-137	COP9 signalosome subunit 3	Homo sapiens	229-234
34139627-4	2021	Molecular docking showed that highly active molecule 5i might bind to DNA gyrase by forming stable hydrogen bonds.	Hydrogen	99-107	DNA topoisomerase II alpha	Homo sapiens	70-80
10529253-5	1999	A new model for the solution structure is proposed in which the 5"-GMP forms a pseudo-four-stranded helix with guanine-guanine hydrogen bonding forming a continuous helical strand, rather than the usual planar G-tetrad structure.	Hydrogen	127-135	5'-nucleotidase, cytosolic II	Homo sapiens	67-70
10471404-8	1999	Also, comparing the mass shift on MALDI spectra of P1 and P2 after hydrogen/deuterium exchange revealed that the modification moiety had five hydroxyl groups.	Hydrogen	67-75	crystallin gamma F, pseudogene	Homo sapiens	51-60
34681645-8	2021	Molecular docking revealed several hydrogen bonds between irisin and MARK4, including critical residues, Lys38, Val40, and Ser134.	Hydrogen	35-43	fibronectin type III domain containing 5	Homo sapiens	58-64
10478487-6	1999	3"-OMe-dC was a superior inhibitor of dCK to its 5"-O-methyl congener, consistent with possible participation of the oxygen of the (3")-OH or (3")-OMe as proton acceptor in hydrogen bonding with the enzyme.	Hydrogen	173-181	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	38-41
34681645-8	2021	Molecular docking revealed several hydrogen bonds between irisin and MARK4, including critical residues, Lys38, Val40, and Ser134.	Hydrogen	35-43	microtubule affinity regulating kinase 4	Homo sapiens	69-74
34651133-15	2021	These data will be foundational to future interventional studies of inhaled hydrogen gas in injury states, including following cardiac arrest.	Hydrogen	76-84	gastrin	Homo sapiens	85-88
34598721-7	2021	RESULTS: The maximum hydrogen yield of 207.65 mL-H2/g-volatile solid (VS)added was obtained from 0.92, 15.27, and 3.82 g-VS/L of Chlorella sp.	Hydrogen	21-29	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	46-51
10404227-3	1999	Pulsed hydrogen exchange monitored by electrospray ionization mass spectrometry demonstrates that GroEL does not alter the folding mechanism, nor are protected species unfolded by the chaperonin.	Hydrogen	7-15	heat shock protein family D (Hsp60) member 1	Homo sapiens	98-103
10357351-4	1999	Fluorine may enhance the anesthetic action of other moieties, such as the hydrogen atom in CHF3 (MAC = 1.60 atm), but, consistent with the notion that the fluorine atoms do not directly influence sites of anesthetic action, adding -(CF2)n moieties does not further increase potency (e.g., CHF2-CF3 MAC = 1.51 atm).	Hydrogen	74-82	integrin subunit alpha M	Homo sapiens	97-104
34233076-8	2021	Molecular docking results suggested that compound 3o can interact with the key amino acid residues, E81, L83 and D146, of CDK1 through hydrogen bond just like flavopiridol does.	Hydrogen	135-143	cyclin dependent kinase 1	Homo sapiens	122-126
10357351-6	1999	However, adding a second terminal hydrogen atom (e.g., CHF2-CHF2 or CH2OH-CHF2) produces series in which the addition of each -CF2- "spacer" in the middle of the molecule increases potency two- to threefold, as in each unhalogenated series.	Hydrogen	34-42	ATPase H+ transporting accessory protein 1	Homo sapiens	127-130
10371437-1	1999	Resolved localized nuclear magnetic resonance (NMR) signals of 1H bound to 13C label in the carbon positions of glutamate C4, C3 and glutamine C4, C3, as well as in aspartate C3, lactate C3, alanine C3, gamma-aminobutyric acid C3, and glucose C1 were simultaneously observed in spectra obtained from rat brain in vivo.	Hydrogen	63-65	complement C3	Rattus norvegicus	126-149
10371437-1	1999	Resolved localized nuclear magnetic resonance (NMR) signals of 1H bound to 13C label in the carbon positions of glutamate C4, C3 and glutamine C4, C3, as well as in aspartate C3, lactate C3, alanine C3, gamma-aminobutyric acid C3, and glucose C1 were simultaneously observed in spectra obtained from rat brain in vivo.	Hydrogen	63-65	complement C3	Rattus norvegicus	175-201
10371151-1	1999	The structure of the chemically synthesized C-terminal region of the human agouti related protein (AGRP) was determined by 2D 1H NMR.	Hydrogen	126-128	agouti related neuropeptide	Homo sapiens	75-97
10371151-1	1999	The structure of the chemically synthesized C-terminal region of the human agouti related protein (AGRP) was determined by 2D 1H NMR.	Hydrogen	126-128	agouti related neuropeptide	Homo sapiens	99-103
10224098-7	1999	Interestingly, this residue aligns with Ser-79 of LBP, which forms a hydrogen bond with the ligand.	Hydrogen	69-77	lipopolysaccharide binding protein	Homo sapiens	50-53
10333174-9	1999	The putative bioactive conformation is characterized by two structural motifs: i) a C14 pseudo-ring stabilized by a hydrogen bond between the amino group of Cys1 and the carboxylate group of Met4 and a C11 pseudo-ring involving the residues Cys1 and Tic3.	Hydrogen	116-124	aldo-keto reductase family 1 member C4	Homo sapiens	202-205
10080895-9	1999	The smaller 1H-15N nuclear Overhauser enhancement values for the residues of loop 3 between beta2 and beta3 suggest that this loop is flexible in the time-scale of nano- to picosecond order.	Hydrogen	12-14	hemoglobin, beta adult minor chain	Mus musculus	92-97
11670913-1	1999	1H NMR spectra of a series of high-spin (meso-tetraalkylporphyrinato)iron(III) chlorides, [Fe(TRP)Cl] where R = Me, Et, Pr, or (i)Pr, have been measured at various temperatures in CD(2)Cl(2) solution.	Hydrogen	0-2	spindlin 1	Homo sapiens	35-39
10052954-8	1999	The G.A mispairs are protonated at N1 of the adenines as in the C.A+ mispairs, and two hydrogen bonds in the G(syn).A+(anti) conformation are formed.	Hydrogen	87-95	synemin	Homo sapiens	111-114
10052954-9	1999	The syn guanine is stabilized by an intranucleotide hydrogen bond between the 2-amino and the 5"-phosphate groups.	Hydrogen	52-60	synemin	Homo sapiens	4-7
10052954-10	1999	The G(syn).A+(anti) conformation can provide a different surface for recognition in the grooves compared to other G.A hydrogen bonding schemes.	Hydrogen	118-126	synemin	Homo sapiens	6-9
11674206-4	1999	Data obtained from spin trapping experiments of a wide variety of free radicals generated in situ showed the formation of two diastereoisomers spin adducts with different phosphorus and hydrogen coupling constants.	Hydrogen	186-194	spindlin 1	Homo sapiens	19-23
11674206-4	1999	Data obtained from spin trapping experiments of a wide variety of free radicals generated in situ showed the formation of two diastereoisomers spin adducts with different phosphorus and hydrogen coupling constants.	Hydrogen	186-194	spindlin 1	Homo sapiens	143-147
11674219-2	1999	In monomer experiments employing C-3"-acylthymidine derivatives 2 and 3, a 1:1 mixture of isomers of the H-abstraction products was obtained when the photolysis was carried out in the presence of a hydrogen donor.	Hydrogen	198-206	complement C3	Homo sapiens	33-36
11674232-4	1999	Hydrogen-atom abstraction from 1,4-CHD by 22, manifesting its radical character, then produces 23.	Hydrogen	0-8	choline dehydrogenase	Homo sapiens	35-38
10029536-8	1999	This shift results in the loss of the hydrogen bond between His 162 and Glu 296 seen in the H91N and turkey delta I crystallin structures; this H-bond is believed to be crucial for the catalytic mechanism of ASL/delta II crystallin.	Hydrogen	38-46	argininosuccinate lyase	Meleagris gallopavo	208-211
10029539-10	1999	Hydrogen bonding of the guanylyl 2"-OH group and the phosphonate moiety is essentially the same as that recently observed for a novel structure of a RNase T1-3"-GMP complex obtained immediately after in situ hydrolysis of exo-(Sp)-guanosine 2",3"-cyclophosphorothioate [Zegers et al.	Hydrogen	0-8	5'-nucleotidase, cytosolic II	Homo sapiens	161-164
9877172-2	1998	Further, it lacked the 1H-NMR signal at 13.1 ppm from 2,2-dimethyl-2-silapentane-5-sulfonate in normal hemoglobin (Hb A), so that this signal was assigned to a hydrogen bond formed by Tyr-35(C1)beta.	Hydrogen	160-168	sodium voltage-gated channel alpha subunit 2	Homo sapiens	115-119
9841653-1	1998	Maple tree sap is a source of environmental sugar (e.g., sucrose) that has the potential to be converted into hydrogen using the enzymes invertase, glucose dehydrogenase (GDH), hydrogenase, and glucose isomerase (GI) and the cofactor NADP+/NADPH. The kinetics of hydrogen production have been studied, and optimal conditions for hydrogen production are described.	Hydrogen	111-119	2,4-dienoyl-CoA reductase 1	Homo sapiens	195-246
9862134-0	1998	Assignments of 1H and 13C resonances in the complex of palmitate and a non-specific lipid transfer protein (ns-LTP) isolated from barley seeds.	Hydrogen	15-17	inducible in root cells subjected to nutrient deprivation	Hordeum vulgare	71-106
9862134-0	1998	Assignments of 1H and 13C resonances in the complex of palmitate and a non-specific lipid transfer protein (ns-LTP) isolated from barley seeds.	Hydrogen	15-17	inducible in root cells subjected to nutrient deprivation	Hordeum vulgare	108-114
9876928-8	1998	Computer analysis of possible interactions involving Cys121 in a three-dimensional structure of beta-lactoglobulin revealed that the thiol group is too far away from neighboring residues to form side-chain hydrogen bonds.	Hydrogen	206-214	beta-lactoglobulin	Bos taurus	96-114
11672368-2	1998	Addition of the double hydrogen bonding acetic acid moderately stabilizes the syn rotamer of 4, but has no measurable effect on the syn/anti ratio for 3.	Hydrogen	23-31	synemin	Homo sapiens	78-81
11672368-3	1998	Conversely, the hydrogen bond donor-acceptor-donor triad in 2,6-bis(octylamido)pyridine, 1, strongly stabilizes the syn rotamer of 3, but has no effect on the syn/anti ratio for 4.	Hydrogen	16-24	synemin	Homo sapiens	116-119
11672368-5	1998	This implies that the alkoxy oxygen in anti-3 is a much poorer hydrogen bond acceptor than the carbonyl oxygen in syn-3, most likely because of a combination of steric and electrostatic factors.	Hydrogen	63-71	synemin	Homo sapiens	114-117
9826183-0	1998	The solution structure of human endothelin-2 a 1H-NMR and CD study.	Hydrogen	47-49	endothelin 2	Homo sapiens	32-44
9781668-1	1998	We have determined a crude structure of the apo form of bovine beta-lactoglobulin, a protein of 162 amino acid residues with a molecular mass of 18 kDa, at a low pH on the basis of data collected using only homonuclear 1H NMR spectroscopy.	Hydrogen	219-221	beta-lactoglobulin	Bos taurus	63-81
9796820-1	1998	Additional interactions possibly involving the well-exposed H2 helical domain of hTBP and the acidic fragment L(281-301) of the non-conserved domain of hTFIIA have been proposed to account for the apparent discrepancies between the results of mutagenesis experiments on human proteins and the structure of the ternary complex TBP/TATA box/TFIIA established from yeast proteins by X-ray crystallography.	Hydrogen	60-62	TATA-box binding protein	Homo sapiens	81-85
9796820-1	1998	Additional interactions possibly involving the well-exposed H2 helical domain of hTBP and the acidic fragment L(281-301) of the non-conserved domain of hTFIIA have been proposed to account for the apparent discrepancies between the results of mutagenesis experiments on human proteins and the structure of the ternary complex TBP/TATA box/TFIIA established from yeast proteins by X-ray crystallography.	Hydrogen	60-62	TATA-box binding protein	Homo sapiens	82-85
9796820-5	1998	Molecular modelling studies indicate that this complex could be stabilized by electrostatic interactions involving the glutamate Glu287 and aspartates (Asp290, Asp294, Asp297 and Asp298) of L(281-301)TFIIA and lysine residues (Lys133, Lys138 and Lys145) and arginine residues (Arg137, Arg140) of H2(TBP) in agreement with mutagenesis experiments.	Hydrogen	296-298	TATA-box binding protein	Homo sapiens	299-302
9705310-1	1998	The high resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 (N-TIMP-2) in solution has been determined using multidimensional heteronuclear NMR spectroscopy, with the structural calculations based on an extensive set of constraints, including 3132 nuclear Overhauser effect-based distance constraints, 56 hydrogen bond constraints, and 220 torsion angle constraints (an average of 26.9 constraints/residue).	Hydrogen	344-352	TIMP metallopeptidase inhibitor 2	Homo sapiens	58-98
9705310-1	1998	The high resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 (N-TIMP-2) in solution has been determined using multidimensional heteronuclear NMR spectroscopy, with the structural calculations based on an extensive set of constraints, including 3132 nuclear Overhauser effect-based distance constraints, 56 hydrogen bond constraints, and 220 torsion angle constraints (an average of 26.9 constraints/residue).	Hydrogen	344-352	TIMP metallopeptidase inhibitor 2	Homo sapiens	102-108
9705310-3	1998	The binding site for the catalytic domain of matrix metalloproteinases-3 (N-MMP-3) on N-TIMP-2 has been mapped by determining the changes in chemical shifts on complex formation for signals from the protein backbone (15N, 13C, and 1H).	Hydrogen	231-233	TIMP metallopeptidase inhibitor 2	Homo sapiens	88-94
9657977-12	1998	Molecular modelling of the rat TK revealed that Arg433 of one monomer has three potential hydrogen-bond interactions with the catalytically important highly conserved loop of the other monomer.	Hydrogen	90-98	transketolase	Rattus norvegicus	31-33
9740377-5	1998	The equivalence of the hydrogen bond pattern of TgHbA (in particular the inter-subunit surfaces) with that of authentic HbA has also been established by NMR studies.	Hydrogen	23-31	sodium voltage-gated channel alpha subunit 2	Homo sapiens	50-53
9630626-6	1998	Comparison of isoacidic and isosteric inhibitors reveals that (i) the hydrogen bond of the amide proton to His-48 is crucial for strong PLA2 inhibition, (ii) regardless of the headgroup unsubstituted N-acyl groups result in optimal amide acidity for PLA2 inhibition and (iii) the exceptionally strong inhibition by acetamides and the isosteric fluoroacetamides is due to an additional steric effect.	Hydrogen	70-78	phospholipase A2 group IIA	Homo sapiens	136-140
9630626-6	1998	Comparison of isoacidic and isosteric inhibitors reveals that (i) the hydrogen bond of the amide proton to His-48 is crucial for strong PLA2 inhibition, (ii) regardless of the headgroup unsubstituted N-acyl groups result in optimal amide acidity for PLA2 inhibition and (iii) the exceptionally strong inhibition by acetamides and the isosteric fluoroacetamides is due to an additional steric effect.	Hydrogen	70-78	phospholipase A2 group IIA	Homo sapiens	250-254
30384717-1	2018	Hydrogen adsorption on Pt(111) has been actively studied using semilocal approximations within the density functional theory featuring simultaneous adsorption of hydrogen on multiple sites, i.e., fcc, atop, and hcp.	Hydrogen	0-8	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	211-214
30352950-6	2018	However, hydrogen-deuterium exchange mass spectrometry data suggested that the regulatory SH3 and SH2 domains packed against the back of the kinase domain in a Src-like manner.	Hydrogen	9-17	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	160-163
30308991-5	2018	The highest H2 evolution rate was observed over P25 based samples and the H2 treatment resulted in more active samples than the other co-catalyst formation methods.	Hydrogen	12-14	tubulin polymerization promoting protein	Homo sapiens	48-51
29594929-4	2018	We report here the nearly complete 1H, 13C and 15N backbone NMR chemical shift assignments of the 11 kDa C-terminal P4 domain of Ahnak.	Hydrogen	35-37	AHNAK nucleoprotein	Homo sapiens	129-134
30099718-7	2018	Here we report the almost complete 1H, 13C, 15N backbone and side chain NMR assignment of a 20.5 kDa EF-P.	Hydrogen	35-37	AT695_RS09875	Staphylococcus aureus	101-105
29803110-7	2018	In addition, BAs increased the expression of the Solute Carrier family 9 member A 2 (P &lt; 0.01) that encodes a sodium hydrogen exchanger.	Hydrogen	120-128	sodium/hydrogen exchanger 2	Capra hircus	49-83
30382050-4	2018	In the present study, we investigated whether hydrogen gas influences the proportion of PD-1+ CD8+ T cells in the peripheral blood of 55 Stage IV colorectal carcinoma patients.	Hydrogen	46-54	CD8a molecule	Homo sapiens	94-97
30382050-6	2018	We also found that the proportion of terminal PD-1+ CD8+ T cells was reduced in 35 out of 55 patients(63.6%)and was increased in 39 out of 55 patients(70.9%)after treatment with hydrogen gas.	Hydrogen	178-186	CD8a molecule	Homo sapiens	52-55
30382050-7	2018	The ratio of the terminal PD-1+ CD8+ T cells after hydrogen gas treatment to that before hydrogen gas treatment(terminal PD-1+ CD8+ T cell ratio)was found to be an independent factor predicting PFS and OS.	Hydrogen	51-59	CD8a molecule	Homo sapiens	32-35
30382050-7	2018	The ratio of the terminal PD-1+ CD8+ T cells after hydrogen gas treatment to that before hydrogen gas treatment(terminal PD-1+ CD8+ T cell ratio)was found to be an independent factor predicting PFS and OS.	Hydrogen	51-59	CD8a molecule	Homo sapiens	127-130
30382050-7	2018	The ratio of the terminal PD-1+ CD8+ T cells after hydrogen gas treatment to that before hydrogen gas treatment(terminal PD-1+ CD8+ T cell ratio)was found to be an independent factor predicting PFS and OS.	Hydrogen	89-97	CD8a molecule	Homo sapiens	127-130
9609687-5	1998	Interaction of TFIIBc with the acidic activation domain of VP16 or with TFIIBn induces 1H-15N chemical shift and line width changes concentrated in the first repeat, interrepeat linker and the first helix of the second repeat.	Hydrogen	87-89	host cell factor C1	Homo sapiens	59-63
34518855-0	2021	Predicting 1H NMR relaxation in Gd3+-aqua using molecular dynamics simulations.	Hydrogen	11-13	GRDX	Homo sapiens	32-35
9601073-3	1998	Two-dimensional 1H-13C NMR spectroscopy of the complexes formed by the derivatized cytochromes with cytochrome b5 and cytochrome c peroxidase has been used to investigate the number and identity of lysine residues of cytochrome c that are involved in interprotein interactions of cytochrome c. The NMR data are incompatible with simple static models proposed previously for the complexes formed by these proteins, but are consistent with the presence of multiple, interconverting complexes of comparable stability, consistent with studies employing Brownian dynamics to model the complexes.	Hydrogen	16-18	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	118-141
34518855-1	2021	Atomistic molecular dynamics simulations are used to predict 1H NMR T1 relaxation of water from paramagnetic Gd3+ ions in solution at 25  C. Simulations of the T1 relaxivity dispersion function r1 computed from the Gd3+-1H dipole-dipole autocorrelation function agree within  8% of measurements in the range f0   5   500 MHz, without any adjustable parameters in the interpretation of the simulations, and without any relaxation models.	Hydrogen	61-63	GRDX	Homo sapiens	109-112
34518855-1	2021	Atomistic molecular dynamics simulations are used to predict 1H NMR T1 relaxation of water from paramagnetic Gd3+ ions in solution at 25  C. Simulations of the T1 relaxivity dispersion function r1 computed from the Gd3+-1H dipole-dipole autocorrelation function agree within  8% of measurements in the range f0   5   500 MHz, without any adjustable parameters in the interpretation of the simulations, and without any relaxation models.	Hydrogen	220-222	GRDX	Homo sapiens	215-218
30382050-9	2018	These results suggest that hydrogen gas improves the prognosis of cancer patients by reducing the proportion of terminal PD-1+ CD8+ T cells.	Hydrogen	27-35	CD8a molecule	Homo sapiens	127-130
34473496-11	2021	The PIP2 lipids can form long-lasting hydrogen bonds with positively charged residues such as Arg and Lys on hBD-3, thus forming clusters with hBD-3.	Hydrogen	38-46	defensin beta 103B	Homo sapiens	109-114
29711226-1	1998	A "one-legged thallium" is observed in the arylthallium(I) compound 2,6-Trip2 C6 H3 Tl (Trip=2,4,6-iPr3 C6 H2 ), which was synthesized from the corresponding organolithium compound and thallium chloride.	Hydrogen	107-109	mediator complex subunit 1	Homo sapiens	72-77
34473496-11	2021	The PIP2 lipids can form long-lasting hydrogen bonds with positively charged residues such as Arg and Lys on hBD-3, thus forming clusters with hBD-3.	Hydrogen	38-46	defensin beta 103B	Homo sapiens	143-148
34505513-3	2021	In this study, TEPC466, a novel TEPP-46-based aggregation-induced emission (AIE) probe for the detection of PKM2, was designed, synthesized, and fully characterized by 1H NMR, 13C NMR, and high-resolution mass spectrometry.	Hydrogen	168-170	pyruvate kinase M1/2	Homo sapiens	108-112
9575185-3	1998	The structures reveal that the preorganized, C2 symmetric scaffolds of the inhibitors are anchored in the active site of the protease by six hydrogen bonds and that their P1 and P2 substituents participate in extensive van der Waals interactions and hydrogen bonds.	Hydrogen	250-258	crystallin gamma F, pseudogene	Homo sapiens	171-180
29842959-5	2018	When F556 was replaced by other amino acids except Trp, the hydrogen bond, JH2 domain"s structural conformation and JH1-JH2 domains" interactions disrupted for changing the helix between beta2 and beta3 strands which finally caused JAK2 activation.	Hydrogen	60-68	hemoglobin, beta adult minor chain	Mus musculus	187-192
34533166-0	2021	Tailoring unique neural-network-type carbon nanofibers inserted in CoP/NC polyhedra for robust hydrogen evolution reaction.	Hydrogen	95-103	caspase recruitment domain family member 16	Homo sapiens	67-70
30235819-4	2018	The increased piezoresponse is attributed to the synergistic effect of the dipole moment associated with the nucleation of the electroactive phase and with the electrostatic interaction between the CF2 group of PVDF and the dissolved salt through hydrogen bonding.	Hydrogen	247-255	ATPase H+ transporting accessory protein 1	Homo sapiens	198-201
30232347-9	2018	Moreover, the expression of Bcl-2, HO-1, and Sirt1 in liver, KCs, and hepatocytes by hydrogen gas were increased, whereas caspase activation, Bax, and acetylation of p53 were suppressed by hydrogen gas.	Hydrogen	189-197	BCL2-associated X protein	Mus musculus	142-145
9559655-0	1998	Solution conformation of an ET(B) selective agonist, ET-1[Cys(Acm)1,15,Ala3,Leu7,Aib11], in CD3OH/H2O by 1H NMR and molecular modelling.	Hydrogen	105-107	ANIB1	Homo sapiens	81-84
34579115-3	2021	Selenoproteins, such as glutathione peroxidase and thioredoxin reductase, play an important role in the reduction of hydrogen and lipid hydroperoxides, and regulate the redox status of Cys in proteins.	Hydrogen	117-125	peroxiredoxin 5	Homo sapiens	51-72
9566728-9	1998	Non-competitive, intermolecular isotope effect experiments, conducted with [12,12,12-2H3]DDA and [11,11-2H2]DDA, demonstrated further that CYP4B1-mediated terminal desaturation of DDA is initiated by removal of a hydrogen atom from the omega-1 rather than the omega position.	Hydrogen	213-221	cytochrome P450 4B1	Oryctolagus cuniculus	139-145
34507982-6	2021	Here, we investigated the mechanism of arrestin-2 scaffolding of cRaf, MEK1, and ERK2 using hydrogen/deuterium exchange-mass spectrometry, tryptophan-induced bimane fluorescence quenching, and NMR.	Hydrogen	92-100	mitogen-activated protein kinase kinase 1	Homo sapiens	71-75
9568282-1	1998	Two catalytic pathways have been proposed for the flavoenzyme monoamine oxidase B (MAO-B)--one based on an initial single electron transfer (SET) step from the nitrogen lone pair and the second based on an initial alpha-carbon hydrogen atom transfer (HAT) step.	Hydrogen	227-235	monoamine oxidase B	Homo sapiens	62-81
9568282-1	1998	Two catalytic pathways have been proposed for the flavoenzyme monoamine oxidase B (MAO-B)--one based on an initial single electron transfer (SET) step from the nitrogen lone pair and the second based on an initial alpha-carbon hydrogen atom transfer (HAT) step.	Hydrogen	227-235	monoamine oxidase B	Homo sapiens	83-88
29685656-5	2018	The protein X-ray crystal structures of 1 and 2 in complex with CA II show that it is not the halogen-hydrophobic interactions that give compound 2 a greater binding energy but a slight movement in orientation of the ribose ring that allows better hydrogen bonds to CA residues.	Hydrogen	248-256	carbonic anhydrase 2	Homo sapiens	64-69
29804978-4	2018	Obvious chemical shift change (Deltad) of typical atoms (H2, H11, C10, and C12) in [Emim]Ac-urea indicated that strong hydrogen bonds were formed between [Emim]Ac and urea.	Hydrogen	119-127	H1.1 linker histone, cluster member	Homo sapiens	61-64
29804978-4	2018	Obvious chemical shift change (Deltad) of typical atoms (H2, H11, C10, and C12) in [Emim]Ac-urea indicated that strong hydrogen bonds were formed between [Emim]Ac and urea.	Hydrogen	119-127	chromosome 12 open reading frame 57	Homo sapiens	66-69
9458372-1	1998	Novel 1H,7H-5a,6,8,9-tetrahydro-1-oxopyrano [4,3-b][1]benzopyrans were synthesized in Hua"s laboratory (code names H5, H10, H14 and H15) and tested for their ability to prevent L1210 leukemic cells from synthesizing macromolecules and growing in vitro.	Hydrogen	6-8	H1.4 linker histone, cluster member	Mus musculus	115-135
34292283-8	2021	We confirmed that eight H2 molecules could stably adsorb on Ti4/BGr with six reversible hydrogen adsorptions.	Hydrogen	88-96	C-type lectin domain containing 7A	Homo sapiens	64-67
9521116-4	1998	The average change in 1H-15N bond vector entropies for residues T3-S15, which become ordered upon binding of the S-peptide to the S-protein, is -12.6+/-1.4 J/mol.residue.K.	Hydrogen	22-24	vitronectin	Homo sapiens	130-139
34292283-9	2021	Our proposed B-doped graphene-based material, Ti4/BGr, offers high cluster-stability on the substrate with high-capacity hydrogen storage compared to various other surfaces in the previous work.	Hydrogen	121-129	C-type lectin domain containing 7A	Homo sapiens	50-53
34259275-3	2021	By molecular docking, we confirmed that the NDEELNK backbone and AChE interacted through hydrophobic and hydrogen bonds in contact with the amino acid residues of the cavity wall.	Hydrogen	105-113	acetylcholinesterase	Rattus norvegicus	65-69
9460244-0	1997	Refined solution structure of the DNA-binding domain of GAL4 and use of 3J(113Cd,1H) in structure determination.	Hydrogen	81-83	galectin 4	Homo sapiens	56-60
9460244-1	1997	We have refined the solution structure of cadmium-bound GAL4 and present its 15N and 1H NMR assignments.	Hydrogen	85-87	galectin 4	Homo sapiens	56-60
29778810-9	2018	The debromination of BDE-21 in Pd-H2 system as well as the solvent kinetic isotope effect in single metal and bimetallic systems suggests that H atom transfer is the dominant mechanism in Fe/Pd system, while e-transfer is still the dominant mechanism in Fe/Ag system.	Hydrogen	34-36	homeobox D13	Homo sapiens	21-24
9460244-3	1997	The three-bond heteronuclear 3J(113Cd,1H) coupling constants were found to disobey a Karplus-type relationship, which was attributable to the unusual constraints imposed by the bimetal-thiolate cluster in GAL4.	Hydrogen	38-40	galectin 4	Homo sapiens	205-209
34576795-7	2021	Biochemical and in silico analyses showed that the amino acid residue at position 79 is involved in the stabilization of the proline binding pocket in Pro1 via a hydrogen-bonding network, which plays an important role in feedback inhibition.	Hydrogen	162-170	glutamate 5-kinase	Saccharomyces cerevisiae S288C	151-155
9581543-1	1997	Colchicide (IDE) is a colchicine (COL) analogue in which the C-10 methoxy group is replaced by a hydrogen atom.	Hydrogen	97-105	insulin degrading enzyme	Homo sapiens	12-15
9399159-1	1997	Recent experimental studies have shown that the Rec-A mediated homologous recombination reaction involves a triple helical intermediate, in which the third strand base forms hydrogen bonds with both the bases in the major groove of the Watson-Crick duplex.	Hydrogen	174-182	RAD51 recombinase	Homo sapiens	48-53
9364740-10	1997	The involvement of these two isoforms in the O-demethylation of 4-nitroanisole can be rationalized in terms of a hydrogen bond interaction with the nitro group and the active site of CYP2A6 and a hydrophobic interaction with the active site of CYP2E1.	Hydrogen	113-121	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	183-189
9254595-4	1997	The results were consistent with homology models of the Grb2-SH2-Shc hexapeptide complex which identified several possible hydrogen bonds between Grb2-SH2 and the phosphotyrosine and conserved asparagine(+2) side chains of the Shc hexapeptide.	Hydrogen	123-131	SHC adaptor protein 1	Homo sapiens	227-230
9135120-7	1997	Comparison of the structure of the proteinase A-difluorostatone complex with that of endothiapepsin bound with the same inhibitor shows that the conformation and hydrogen bond interactions of the inhibitor in the active site are very similar, even though the enzymes have only 27% sequence identity.	Hydrogen	162-170	proteinase A	Saccharomyces cerevisiae S288C	35-47
9135122-0	1997	Solution structure of the Grb2 N-terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts.	Hydrogen	156-158	growth factor receptor bound protein 2	Mus musculus	26-30
9133623-0	1997	Hydrogen-exchange kinetics of reduced alpha-lactalbumin bound to the chaperonin GroEL.	Hydrogen	0-8	heat shock protein family D (Hsp60) member 1	Homo sapiens	80-85
9133623-4	1997	Our results show that the hydrogen-exchange kinetics of RLA bound to GroEL is identical to that of free RLA.	Hydrogen	26-34	heat shock protein family D (Hsp60) member 1	Homo sapiens	69-74
9047330-4	1997	A majority of the residues in both apo and holo I-FABP were characterized by relatively slow hydrogen exchange rates, high generalized order parameters, and no conformational exchange terms.	Hydrogen	93-101	fatty acid binding protein 2	Rattus norvegicus	48-54
9047330-5	1997	However, residues V26-N35, S53-R56, and A73-T76 of apo I-FABP were characterized by rapid hydrogen exchange, low order parameters, and significant conformational exchange.	Hydrogen	90-98	fatty acid binding protein 2	Rattus norvegicus	55-61
9585973-2	1997	From CD and NOE spectra, anomalous syn orientation of Urd-5"-NH2 might be caused by specific interaction between borates and Urd-5"-NH2, which promote the formation of hydrogen bonding between 2-carbonyl oxygen and hydrogen of 5"-amino group.	Hydrogen	168-176	synemin	Homo sapiens	35-38
9585973-2	1997	From CD and NOE spectra, anomalous syn orientation of Urd-5"-NH2 might be caused by specific interaction between borates and Urd-5"-NH2, which promote the formation of hydrogen bonding between 2-carbonyl oxygen and hydrogen of 5"-amino group.	Hydrogen	215-223	synemin	Homo sapiens	35-38
9000633-0	1996	Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II.	Hydrogen	88-90	carbonic anhydrase 2	Homo sapiens	112-133
8973169-11	1996	On the basis of a computer-assisted molecular modeling analysis, it was determined that addition of a hydroxyl to the naphthyl 4-position, giving [1, 1-difluoro-1-[2-(4-hydroxynaphthalenyl)] methyl]phosphonic acid (8), could potentially replace a water molecule situated in the PTP1B-6 complex, thereby allowing new hydrogen-bonding interactions with Lys 120 and Tyr 46.	Hydrogen	316-324	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	278-283
8973170-11	1996	A four-state model is presented to explain the chromophore structural changes in Pr, lumi-R, and Pfr that uses hydrogen bonding to the surrounding protein to stabilize the high-energy Pfr C15 = C16, C14-C15, E,anti chromophore structure.	Hydrogen	111-119	placenta associated 8	Homo sapiens	188-191
8973170-11	1996	A four-state model is presented to explain the chromophore structural changes in Pr, lumi-R, and Pfr that uses hydrogen bonding to the surrounding protein to stabilize the high-energy Pfr C15 = C16, C14-C15, E,anti chromophore structure.	Hydrogen	111-119	placenta associated 8	Homo sapiens	203-206
8898111-1	1996	1H-NMR spectroscopy and analytical ultracentrifugation studies reveal that monocyte chemoattractant protein-3 (MCP-3) is a monomer.	Hydrogen	0-2	C-C motif chemokine ligand 7	Homo sapiens	75-109
8898111-1	1996	1H-NMR spectroscopy and analytical ultracentrifugation studies reveal that monocyte chemoattractant protein-3 (MCP-3) is a monomer.	Hydrogen	0-2	C-C motif chemokine ligand 7	Homo sapiens	111-116
8873598-6	1996	On the refined model a well-formed hydrogen bond between T (N3H) and epsilon C(N4) stabilizes the epsilon C(syn).T(anti) base pair alignment, reflecting the preference of the adduct for the syn orientation.	Hydrogen	35-43	synemin	Homo sapiens	108-111
8873598-6	1996	On the refined model a well-formed hydrogen bond between T (N3H) and epsilon C(N4) stabilizes the epsilon C(syn).T(anti) base pair alignment, reflecting the preference of the adduct for the syn orientation.	Hydrogen	35-43	synemin	Homo sapiens	190-193
8864223-5	1996	NMR spectroscopic analysis of 9, including two-dimensional HOHAHA and 1H-(13)C correlation experiments revealed that the benzylidene group bridged the O-2 and O-3 positions of contiguous D-glucopyranosyl residues.	Hydrogen	70-72	immunoglobulin kappa variable 1D-39	Homo sapiens	151-162
8810903-12	1996	Simple modeling indicates that the amino group of the substrate glycine can be placed close to the methyl group of AdoMet within 3.0 A and form a hydrogen bond with the carboxyl group of Glu15 of the adjacent subunit.	Hydrogen	146-154	methionine adenosyltransferase 1A	Rattus norvegicus	115-121
8914273-0	1996	1H, 13C and 15N NMR assignments and secondary structure of the paramagnetic form of rat cytochrome b5.	Hydrogen	0-2	cytochrome b5 type A	Rattus norvegicus	88-101
8888142-4	1996	Further, the simulations show that such a small difference in binding free energies is due to (1) weaker hydrogen bond interactions between the two (P1 and P1") NH groups of A-74704 with Gly27/Gly27" carbonyls of the enzyme and (2) the higher desolvation free energy of A-74704 compared with its ester analog.	Hydrogen	105-113	crystallin gamma F, pseudogene	Homo sapiens	149-159
8780512-0	1996	Protonation-state dependence of hydrogen bond strengths and exchange rates in a serine protease catalytic triad: bovine chymotrypsinogen A.	Hydrogen	32-40	chymotrypsinogen A	Bos taurus	120-138
8702471-3	1996	The RecA protein crystal structure suggests that cofactor specificity is determined by Asp100, which likely forms a hydrogen bond with the exocyclic 6-amino group of ATP; the higher S0.	Hydrogen	116-124	RAD51 recombinase	Homo sapiens	4-8
8730718-5	1996	Systemic administration of methamphetamine (1-5 mg/kg) inhibited light (300 lux, 1h)-induced Fos expression in the suprachiasmatic nucleus; methamphetamine at a dose of 5 mg/kg, i.p.	Hydrogen	81-83	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	93-96
11666171-3	1996	The molecular structure consists of [Fe(TRIM)(2)](2+) complex cations hydrogen-bonded to six fluoride anions.	Hydrogen	70-78	T cell receptor associated transmembrane adaptor 1	Homo sapiens	40-44
29738867-6	2018	Altogether, our results indicate that hesperidin interacted strongly with the key residues of the PLK-1 active site (such as Leu59, Lys61, Lys82, Cys133, Asn181, Asp194, Leu59, Cys67, Ala80, Val114, Leu130, Leu132, Cys133, Leu139, Phe183, and Phe195) through hydrogen bonding and hydrophobic interactions.	Hydrogen	259-267	polo like kinase 1	Homo sapiens	98-103
29677741-2	2018	The activation of Mg-5TaF5 was not necessary, and Mg-5TaF5 had an effective hydrogen storage capacity (the quantity of hydrogen absorbed for 60 min) larger than 5 wt%.	Hydrogen	76-84	TATA-box binding protein associated factor 5	Homo sapiens	54-58
29677741-2	2018	The activation of Mg-5TaF5 was not necessary, and Mg-5TaF5 had an effective hydrogen storage capacity (the quantity of hydrogen absorbed for 60 min) larger than 5 wt%.	Hydrogen	119-127	TATA-box binding protein associated factor 5	Homo sapiens	54-58
29702262-7	2018	The reduction of GR content, by gene silencing, abolished the Aldo effect on NHE1, in low concentration, confirming the importance of this receptor in the rapid modulation of proximal sodium and hydrogen transports.	Hydrogen	195-203	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	17-19
30006143-6	2018	The molecular simulation performance showed that 7b forms additional strong hydrogen bonds with the BTK protein.	Hydrogen	76-84	Bruton tyrosine kinase	Homo sapiens	100-103
30039145-2	2018	Hydrogen bonding between three-dimensional Lander-DAT molecules and planar PTCDI molecules, adsorbed closer to the surface, is found to be facilitated by electrostatic interactions between co-adsorbed Ni adatoms and the flexible molecular DAT groups.	Hydrogen	0-8	solute carrier family 6 member 3	Homo sapiens	50-53
30039145-2	2018	Hydrogen bonding between three-dimensional Lander-DAT molecules and planar PTCDI molecules, adsorbed closer to the surface, is found to be facilitated by electrostatic interactions between co-adsorbed Ni adatoms and the flexible molecular DAT groups.	Hydrogen	0-8	solute carrier family 6 member 3	Homo sapiens	239-242
30068164-6	2018	The probability of elimination of the hydrogen atom from two terminal groups (terminal hydrogen elimination) is greater than that from the internal CH2 group (internal hydrogen elimination).	Hydrogen	38-46	alien	Drosophila melanogaster	148-151
31458945-3	2018	Subsequently, biopolymers could anchor CuS-NCs on CNF by the hydrogen bonding.	Hydrogen	61-69	NPHS1 adhesion molecule, nephrin	Homo sapiens	50-53
29714400-4	2018	When this bifunctional catalyst was further used for H2 and O2 production in an electrochemical water-splitting unit, it can operate in ambient conditions with a competitive gas production rate of 1.15 and 0.57 muL s-1 for hydrogen and oxygen, respectively, showing its potential for practical applications.	Hydrogen	223-231	relaxin 2	Homo sapiens	53-62
29807433-2	2018	The mechanism of PBP-phosphate recognition remains controversial: on the basis of similar binding affinities at acidic and basic pHs, it is believed that the hydrogen network in the binding site is flexible to adapt to different protonation states of phosphates.	Hydrogen	158-166	phosphatidylethanolamine binding protein 1	Homo sapiens	17-20
29807433-6	2018	The binding of dihydrogen (2H) phosphate disrupted the hydrogen-bond network in the PBP pocket, and the computed affinity was much weaker than that of 1H phosphate.	Hydrogen	17-25	phosphatidylethanolamine binding protein 1	Homo sapiens	84-87
29691138-4	2018	A co-crystal structure of KDM4A TUDOR domain in complex with 1a shows that the fragment binds stereo-specifically to the methyl lysine binding pocket forming a network of strong hydrogen bonds and hydrophobic interactions.	Hydrogen	178-186	lysine demethylase 4A	Homo sapiens	26-31
29723807-9	2018	The binding mode analysis showed that Asn47 of CBX2 formed a hydrogen bond with the OH group of C-terminal cap of UNC3866, inducing the conformational changes of diethyllysine of UNC3866 that is obviously different from that in CBX7.	Hydrogen	61-69	chromobox 2	Homo sapiens	47-51
27549815-5	2018	Molecular docking reveals the binding interaction of beta-catenin and ganoderic acid A with GScore (-9.44), kcal/mol, lipophilic EvdW (-2.86), electro (-0.72), Glide emodel (-50.401), MM-GBSA (-87.441), H bond (-1.91) with Lys 180 and Asn 220 residues involved in hydrogen bonding.	Hydrogen	264-272	catenin (cadherin associated protein), beta 1	Mus musculus	53-65
29479807-11	2018	Docking simulation analysis further authenticated that 7,8,4 -trihydroxyflavone could form hydrogen bonds with the residues His244 and Met280 within the tyrosinase active site.	Hydrogen	91-99	tyrosinase	Homo sapiens	153-163
8924579-0	1996	Solution structure of an oligodeoxynucleotide containing the human N-ras codon 12 sequence refined from 1H NMR using molecular dynamics restrained by nuclear Overhauser effects.	Hydrogen	104-106	NRAS proto-oncogene, GTPase	Homo sapiens	67-72
8924579-1	1996	The structure of d(GGCAGGTGGTG).d(CACCACCTGCC), consisting of codons 11, 12 (underlined), and 13 of the human n-ras protooncogene, was refined from 1H NMR data.	Hydrogen	148-150	NRAS proto-oncogene, GTPase	Homo sapiens	110-115
34522898-4	2021	Molecular dynamic simulation and molecular docking displayed that AESE was the most potent DPP-IV inhibitory peptide and can bind with the active sites of DPP-IV through hydrogen bonding and van der Waals forces.	Hydrogen	170-178	dipeptidyl peptidase 4	Homo sapiens	91-97
8524862-2	1995	The base-pair specificity of the phosphate alkylation results from Hoogsteen-type hydrogen bonding of the reduced PBI in the major groove at only A.T and G.C base pairs.	Hydrogen	82-90	submaxillary gland androgen regulated protein 3A	Homo sapiens	114-117
8520225-1	1995	For methine sites the relaxation rate of 13C-1H two-spin coherence is generally slower than the relaxation rate of the individual 13C and 1H single spin coherences.	Hydrogen	45-47	spindlin 1	Homo sapiens	52-56
8520225-3	1995	To avoid dephasing of the two-spin coherence caused by 1H-1H J-couplings, the 1H spin is locked by the application of a weak rf field, resulting in a spin-locked multiple quantum coherence.	Hydrogen	55-57	spindlin 1	Homo sapiens	30-34
8520225-3	1995	To avoid dephasing of the two-spin coherence caused by 1H-1H J-couplings, the 1H spin is locked by the application of a weak rf field, resulting in a spin-locked multiple quantum coherence.	Hydrogen	55-57	spindlin 1	Homo sapiens	81-85
8520225-3	1995	To avoid dephasing of the two-spin coherence caused by 1H-1H J-couplings, the 1H spin is locked by the application of a weak rf field, resulting in a spin-locked multiple quantum coherence.	Hydrogen	55-57	spindlin 1	Homo sapiens	81-85
8520225-3	1995	To avoid dephasing of the two-spin coherence caused by 1H-1H J-couplings, the 1H spin is locked by the application of a weak rf field, resulting in a spin-locked multiple quantum coherence.	Hydrogen	58-60	spindlin 1	Homo sapiens	30-34
8520225-3	1995	To avoid dephasing of the two-spin coherence caused by 1H-1H J-couplings, the 1H spin is locked by the application of a weak rf field, resulting in a spin-locked multiple quantum coherence.	Hydrogen	58-60	spindlin 1	Homo sapiens	81-85
8520225-3	1995	To avoid dephasing of the two-spin coherence caused by 1H-1H J-couplings, the 1H spin is locked by the application of a weak rf field, resulting in a spin-locked multiple quantum coherence.	Hydrogen	58-60	spindlin 1	Homo sapiens	81-85
34522898-4	2021	Molecular dynamic simulation and molecular docking displayed that AESE was the most potent DPP-IV inhibitory peptide and can bind with the active sites of DPP-IV through hydrogen bonding and van der Waals forces.	Hydrogen	170-178	dipeptidyl peptidase 4	Homo sapiens	155-161
34415761-9	2021	Further molecular docking results showed that there are hydrogen bonds between compounds 12, 17, and tobacco mosaic virus CP.	Hydrogen	56-64	ceruloplasmin	Homo sapiens	122-124
7577919-3	1995	All 10 1H-13C correlations in the heteronuclear single- and multiple-quantum coherence (HSMQC) spectrum of [13C-methyl] Met cTnC in the complex with cTnI(33-211) were previously assigned [Krudy, G. A., Kleerekoper, Q., Guo, X., Howarth, J. W., Solaro, R. J., &amp; Rosevear, P. R. (1994) J. Biol.	Hydrogen	7-9	troponin I3, cardiac type	Homo sapiens	149-153
34384784-6	2021	Molecular simulations reveal MIF-2 to contain a comparable hydrogen bond network to that of MIF, which was previously hypothesized to influence catalytic activity by modulating the strength of allosteric coupling.	Hydrogen	59-67	centromere protein C	Homo sapiens	29-34
7479027-1	1995	1H- and 31P-NMR and UV-absorption studies were carried out with the oligonucleotide strands d(AGCT-TATC-ATC-GATAAGCT) (-ATC-) and d(AGCTTATC-GAT-GATAAGCT) (-GAT-) contained in the strongest and salt resistant cleavage site for topoisomerase II in pBR322 DNA.	Hydrogen	0-2	glycine-N-acyltransferase	Homo sapiens	108-111
34192656-4	2021	The PED results compared with the Gauss View animation, as our reassignments, and the experimental IR shifts upon deuteration of hydrogen in the OH and CHalpha.	Hydrogen	129-137	transcription factor like 5	Homo sapiens	152-159
7547955-6	1995	The pH dependence of the dissociation constant suggests the alpha-amine of the amino acid must be unprotonated for nucleophilic attack at C4" of PLP, and an enzyme side chain must be unprotonated to hydrogen-bond the thiol or hydroxyl side chain of the amino acid.	Hydrogen	199-207	proteolipid protein 1	Homo sapiens	145-148
7492731-0	1995	Solution structure of an oligodeoxynucleotide containing the human n-ras codon 61 sequence refined from 1H NMR using molecular dynamics restrained by nuclear Overhauser effects.	Hydrogen	104-106	NRAS proto-oncogene, GTPase	Homo sapiens	67-72
7492731-2	1995	d(CTTCTTGTCCG), which consists of codons 60, 61 (underlined), and 62 of the human n-ras protooncogene, was refined from 1H NMR data.	Hydrogen	120-122	NRAS proto-oncogene, GTPase	Homo sapiens	82-87
34485929-6	2021	Molecular dynamics simulations of their DOC-bound forms supported the above findings and revealed that the enlarged space of CYP11B2 had a hydrogen bonding network involving water molecules that position DOC.	Hydrogen	139-147	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	125-132
8527646-4	1995	By invoking this "relayed imidic acid exchange mechanism," which should be essentially acid-catalyzed, we can explain the surprisingly high pHmin (the pH value at which kex reaches a minimum) found for the non-hydrogen-bonded amide protons in the beta-sheet in BPTI.	Hydrogen	210-218	spleen trypsin inhibitor I	Bos taurus	261-265
8527646-5	1995	The successive increase of pHmin along a chain of hydrogen-bonded peptides from the free amide to the free carbonyl, observed in BPTI, can be explained as an increasing contribution of the proposed mechanism in this direction of the chain.	Hydrogen	50-58	spleen trypsin inhibitor I	Bos taurus	129-133
34577533-8	2021	We speculate that the tert-alcohol functionality of TBMA-I promotes intermolecular hydrogen bonding, which enhances the elution efficiency and stability of (18F)fluoride during nucleophilic 18F-fluorination.	Hydrogen	83-91	telomerase reverse transcriptase	Homo sapiens	22-26
7552731-4	1995	Unlike aldose reductase, the N epsilon 2 of the imidazole ring of His 113 in aldehyde reductase interacts, through a hydrogen bond, with the amide group of the nicotinamide ring of NADPH.	Hydrogen	117-125	aldo-keto reductase family 1 member A1	Homo sapiens	77-95
34400635-3	2021	Here, using hydrogen deuterium exchange mass spectrometry (HDX-MS), small angle X-ray scattering (SAXS) and molecular dynamics (MD) simulations, combined with analysis of SMAD signaling, we show that the kinase domain of the type I receptor ALK2 and type II receptor BMPR2 form a heterodimeric complex via their C-terminal lobes.	Hydrogen	12-20	bone morphogenetic protein receptor type 2	Homo sapiens	267-272
7601138-2	1995	The G.G mismatch, which also occurs in the G-quartet structure, has been shown by both x-ray crystallography and NMR to adopt G(anti).G(syn) mispairs, with very different hydrogen bonding patterns [Skelly, J., Edwards, K., Jenkins, T. C. &amp; Neidle, S. (1993) Proc.	Hydrogen	171-179	synemin	Homo sapiens	136-139
34293617-8	2021	Moreover, docking experiments revealed the presence of hydrogen bond interactions between the N-acetyl group of the glucosaminopyranose moiety of the evaluated galactosides and specific amino acid residues of Gal-1, relevant for galectin-glycan affinity.	Hydrogen	55-63	galectin 1	Homo sapiens	209-214
7789519-4	1995	These findings in the light of the 3D structure of G6PD suggest that the epsilon-amino group of lysine 205 can favour a hydrogen bond within the active pocket essential for catalysis.	Hydrogen	120-128	glucose-6-phosphate dehydrogenase	Homo sapiens	51-55
7538590-3	1995	The SAR also indicated that the major interactions of 1h with the RT enzyme are through hydrogen bonding of the amide and benzophenone carbonyls and pi-orbital interactions with the benzophenone nucleus and an aromatic function separated from the benzophenone by a suitable spacer group.	Hydrogen	54-56	sarcosine dehydrogenase	Homo sapiens	4-7
7538590-3	1995	The SAR also indicated that the major interactions of 1h with the RT enzyme are through hydrogen bonding of the amide and benzophenone carbonyls and pi-orbital interactions with the benzophenone nucleus and an aromatic function separated from the benzophenone by a suitable spacer group.	Hydrogen	88-96	sarcosine dehydrogenase	Homo sapiens	4-7
7721776-7	1995	Fuc-TIII and Fuc-TV catalyzed fucose transfer exclusively to OH-3 of glucose in lacto-N-neotetraose and lacto-N-tetraose, respectively, as was demonstrated by 1H NMR spectroscopy.	Hydrogen	159-161	fucosyltransferase 5	Homo sapiens	13-19
34820578-0	2022	Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis.	Hydrogen	22-30	transformation related protein 53, pseudogene	Mus musculus	68-71
7723028-1	1995	We have obtained backbone 1H, 15N, and 13C assignments and determined the secondary structure and folding topology of the C-terminal RNA-binding domain (RBD) of the human U1A protein.	Hydrogen	26-28	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	171-174
34820578-6	2022	We find that the localized release of hydrogen increases the expression level of P53 tumor suppressor proteins, as demonstrated by the in vitro RNA sequencing and protein expression analysis.	Hydrogen	38-46	transformation related protein 53, pseudogene	Mus musculus	81-84
7723029-5	1995	The Com protein requires zinc in order to fold into its functional tertiary structure, as demonstrated by characteristic 1H nuclear magnetic resonance (NMR) chemical shifts.	Hydrogen	121-123	Com family DNA-binding transcriptional regulator	Escherichia phage Mu	4-7
34149882-7	2021	Hydrogen gas post-conditioning significantly alleviated brain edema and improved neurologic function, reduced ROS production and neuronal pyroptosis, suppressed the expression of IL-1beta and IL-18 whilst upregulating ERK1/2 phosphorylation, but downregulated p38 MAPK activation 24 h post-SAH.	Hydrogen	0-8	interleukin 18	Rattus norvegicus	192-197
7723029-7	1995	The metal-binding specificity and thermal stability of Com also has been investigated using 1H NMR.	Hydrogen	92-94	Com family DNA-binding transcriptional regulator	Escherichia phage Mu	55-58
33714327-7	2021	TiH1.924 remained undercomposed even after dehydriding at 623 K in a vacuum for 2 h. The hydriding and dehydriding properties of Mg-10TiCl3 were compared with those of other specimens such as Mg-10Fe2O3, Mg-10NbF5, and Mg-5Fe2O3-5Ni, for which the hydrogen-storage properties were previously reported.	Hydrogen	248-256	pleckstrin homology like domain family A member 3	Homo sapiens	0-4
7731789-3	1995	Homology model building experiments on HMG-1 box sequences "threaded" through the 1H-NMR structure of an HMG-1 box from rat indicate that the domain does not have rigid sequence requirements for its formation.	Hydrogen	82-84	high mobility group box 1	Rattus norvegicus	39-44
7731789-3	1995	Homology model building experiments on HMG-1 box sequences "threaded" through the 1H-NMR structure of an HMG-1 box from rat indicate that the domain does not have rigid sequence requirements for its formation.	Hydrogen	82-84	high mobility group box 1	Rattus norvegicus	105-110
29945385-7	2018	Following 1H-NMR and LC-MS/MS assays, P1 and P2 were unambiguously identified as acteoside and cistanoside A, respectively.	Hydrogen	10-12	crystallin gamma F, pseudogene	Homo sapiens	38-47
34286666-11	2021	HighlightsHsp90 inhibitors that entered different phases of clinical trials were subjected to Zinc15 based structure query to afford potential enzyme inhibitors 19 and 20.Quantum chemical calculations confirmed docking results and verified pivotal role of a conserved residues (Asn51, Leu103, Phe138 and Tyr139) in making effective hydrogen bonds.MD simulations of top-ranked docked derivatives revealed the achievement of stable binding modes with less conformational variation of 20 than 19 in the active site of Hsp90-alpha NTD.H-bond, hydrophobic contacts and salt bridge interactions were determinant forces in binding interactions of in silico hits.Resorcinol and isoxazole were important structural motifs of in silico hits in binding to the active site of Hsp90-alpha NTD.Communicated by Ramaswamy H. Sarma.	Hydrogen	332-340	heat shock protein 90 alpha family class A member 1	Homo sapiens	515-526
7806518-1	1994	The three-dimensional solution structure of the growth-related protein-alpha/melanoma growth stimulatory activity (GRO/MGSA) has been solved by two-dimensional 1H nuclear magnetic resonance spectroscopy.	Hydrogen	160-162	C-X-C motif chemokine ligand 1	Homo sapiens	119-123
7918422-0	1994	Studies of protein-protein association between yeast cytochrome c peroxidase and yeast iso-1 ferricytochrome c by hydrogen-deuterium exchange labeling and proton NMR spectroscopy.	Hydrogen	114-122	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	53-76
29843741-12	2018	Crystal structural analysis further indicated that the substitution from arginine to tryptophan at the highly conserved residue 419 of TULP1 could lead to the elimination of two hydrogen bonds between residue 419 and residues V488 and S534.	Hydrogen	178-186	TUB like protein 1	Homo sapiens	135-140
34116056-7	2021	This hydrogen bond is mediated by the backbone carbonyl of Asn30 in the nucleotide binding domain (NBD) of RagA or Lys84 of RagC, and the hydroxyl group on the side chain of Thr210 in the C-terminal roadblock domain (CRD) of RagA or Ser266 of RagC, respectively.	Hydrogen	5-13	Ras related GTP binding A	Homo sapiens	107-111
15299369-8	1994	It is proposed that the presence of the inhibitor Au(CN)(2)(-) results in a conformational reorientation of the activity-linked group, due to hydrogen-bond formation with the inhibitor, which in turn sterically hinders the binding of the substrate CO(2) molecule in the active site, leading to the inhibition of HCAI enzyme.	Hydrogen	142-150	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	312-316
34116056-7	2021	This hydrogen bond is mediated by the backbone carbonyl of Asn30 in the nucleotide binding domain (NBD) of RagA or Lys84 of RagC, and the hydroxyl group on the side chain of Thr210 in the C-terminal roadblock domain (CRD) of RagA or Ser266 of RagC, respectively.	Hydrogen	5-13	Ras related GTP binding C	Homo sapiens	124-128
29744490-0	2018	Hydrogen-atom tunneling through a very high barrier; spontaneous thiol   thione conversion in thiourea isolated in low-temperature Ar, Ne, H2 and D2 matrices.	Hydrogen	0-8	relaxin 2	Homo sapiens	139-148
34116056-7	2021	This hydrogen bond is mediated by the backbone carbonyl of Asn30 in the nucleotide binding domain (NBD) of RagA or Lys84 of RagC, and the hydroxyl group on the side chain of Thr210 in the C-terminal roadblock domain (CRD) of RagA or Ser266 of RagC, respectively.	Hydrogen	5-13	Ras related GTP binding A	Homo sapiens	225-229
34116056-7	2021	This hydrogen bond is mediated by the backbone carbonyl of Asn30 in the nucleotide binding domain (NBD) of RagA or Lys84 of RagC, and the hydroxyl group on the side chain of Thr210 in the C-terminal roadblock domain (CRD) of RagA or Ser266 of RagC, respectively.	Hydrogen	5-13	Ras related GTP binding C	Homo sapiens	243-247
8057381-2	1994	The T.CG triple, which expands the triplex code, is stabilized by a single hydrogen bond between the O-2 atom of thymine and the free amino proton of cytosine in the Watson-Crick C.G base-pair.	Hydrogen	75-83	immunoglobulin kappa variable 1D-39	Homo sapiens	101-104
34111848-0	2021	Tip-Induced beta-Hydrogen Dissociation in an Alkyl Group Bound on Si(001).	Hydrogen	17-25	TOR signaling pathway regulator	Homo sapiens	0-3
7963506-1	1994	OBJECTIVE: To examine the mechanism of increased Na-H antiport activity in tissues of the spontaneously hypertensive rat (SHR) by measuring the amount of sodium-hydrogen exchanger isoform 1 (NHE-1) in cultured vascular and striated muscle cells, and in ex vivo tissue extracts of membranes from the brain, heart, kidney and skeletal muscle.	Hydrogen	161-169	solute carrier family 9 member A1	Rattus norvegicus	191-196
29761189-5	2018	The H2 is released by AlH3 firstly and then it reacts with NO2 and CO2 from the decomposition of RDX, leading to an increase of H2O, NO and CO.	Hydrogen	4-6	radixin	Homo sapiens	97-100
34927988-3	2021	Benefitting from the heterostructured engineering, the as-synthesized CoFe PBA@CoP presents remarkable electrocatalytic performance in 1.0 m KOH, only requiring overpotentials of 100 mV for hydrogen evolution reaction (HER) and 171 mV for oxygen evolution reaction (OER) to reach the 10 mA cm-2 current density with good stability.	Hydrogen	190-198	caspase recruitment domain family member 16	Homo sapiens	79-82
8172893-6	1994	In this bound conformation, short interatomic distances between Abe O-2 and Gal O-2 permit an oligosaccharide intramolecular hydrogen bond.	Hydrogen	125-133	immunoglobulin kappa variable 1D-39	Homo sapiens	68-83
8172893-8	1994	In DMSO, a different intramolecular hydrogen bond between Abe O-2 and Man O-4 was observed due to a solvent-induced shift in the conformational equilibria (relative to aqueous solution).	Hydrogen	36-44	immunoglobulin kappa variable 1D-39	Homo sapiens	62-77
34195881-7	2021	It was proved that hydrogen bonding between CPE and adhesive would increase drug release rate, but only if the CPE showed good miscibility with adhesive.	Hydrogen	19-27	carboxypeptidase E	Homo sapiens	44-47
8179322-4	1994	The structural characterization of the carbohydrate moieties of G-1, G-2, and G-3 involved glycosyl composition analysis, methylation studies, sequential exoglycosidase hydrolysis, and one-dimensional 1H NMR spectroscopy of the native gangliosides.	Hydrogen	201-203	proline rich protein BstNI subfamily 3	Homo sapiens	64-81
30307203-1	2018	We report a concerted theoretical and experimental effort to determine the reorientational dynamics as well as hydrogen bond lifetimes for the doubly ionic hydrogen bond +OH O- in the ionic liquid (2-hydroxyethyl)trimethylammonium bis(trifluoromethylsulfonyl)imide [Ch][NTf2] by using a combination of NMR relaxation time experiments, density functional theory (DFT) calculations, and molecular dynamics (MD) simulations.	Hydrogen	156-164	nuclear transport factor 2	Homo sapiens	270-274
34195881-7	2021	It was proved that hydrogen bonding between CPE and adhesive would increase drug release rate, but only if the CPE showed good miscibility with adhesive.	Hydrogen	19-27	carboxypeptidase E	Homo sapiens	111-114
34602699-5	2021	We also disclose the cooperative reactivity of 1/ZnX2 pairs (X = Cl, Br, I, and OTf) toward water and dihydrogen, which can be understood in terms of bimetallic frustration.	Hydrogen	102-112	chromosome 12 open reading frame 73	Homo sapiens	69-71
29888265-0	2018	Hydrogen-Rich Saline Activated Autophagy via HIF-1alpha Pathways in Neuropathic Pain Model.	Hydrogen	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	45-55
8142401-7	1994	The observations provide solid evidence for the hypothesis that only iron (III) lipoxygenase can catalyze the hydrogen abstraction step in the dioxygenation reaction, and thus can be regarded as the active enzyme species.	Hydrogen	110-118	linoleate 9S-lipoxygenase-4	Glycine max	80-92
34603793-8	2021	Results: Arctigenin could bind to the catalytic domain of PDE4D via formation of hydrogen bonds as well as pi-pi stacking interactions between the dibenzyl butyrolactone of arctigenin and several residues of PDE4D.	Hydrogen	81-89	phosphodiesterase 4D, cAMP specific	Mus musculus	58-63
8136351-1	1994	EPR and 1H, 14,15N ENDOR spectra are described for the type 1 and type 2 Cu(II) centers of dissimilatory nitrite reductase (NiR) from Alcaligenes xylosoxidans.	Hydrogen	8-10	nitrite reductase large subunit	Achromobacter xylosoxidans	105-122
8136351-1	1994	EPR and 1H, 14,15N ENDOR spectra are described for the type 1 and type 2 Cu(II) centers of dissimilatory nitrite reductase (NiR) from Alcaligenes xylosoxidans.	Hydrogen	8-10	nitrite reductase large subunit	Achromobacter xylosoxidans	124-127
34467285-1	2021	The design of a powerful heterojunction structure and the study of the interfacial charge migration pathway at the atomic level are essential to mitigate the photocorrosion and recombination of electron-hole pairs of CdS in photocatalytic hydrogen evolution (PHE).	Hydrogen	239-247	CDP-diacylglycerol synthase 1	Homo sapiens	217-220
8130221-1	1994	The complex of a monomer of GAL4 with DNA has been investigated by two-dimensional 1H nuclear magnetic resonance (NMR) spectroscopy.	Hydrogen	83-85	galectin 4	Homo sapiens	28-32
8130221-6	1994	With a basis of chemical shift data for free GAL4 protein and for the free half-site DNA, the fast exchange facilitates 1H resonance assignments in the complex since cross-peak positions can be examined at different protein:DNA ratios.	Hydrogen	120-122	galectin 4	Homo sapiens	45-49
29253770-6	2018	Molecular docking studies revealed that F-53B binds to transthyretin (TTR) by forming hydrogen bonds with Lys123 and Lys115, thereby interfering with thyroid hormone homeostasis.	Hydrogen	86-94	transthyretin	Rattus norvegicus	70-73
35487350-0	2022	CdS-based artificial leaf for photocatalytic hydrogen evolution and simultaneous degradation of biological wastewater.	Hydrogen	45-53	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
8117735-4	1994	Most analogs of guanosine with substituents at C8 have a preference for the syn conformation; however, some C8-substituted analogs have the potential to form a hydrogen bond between the C8 substituent and the 5"-hydroxyl that would stabilize the anti conformation; we have found that analogs with the potential to form such a hydrogen bond are more active substrates than those that cannot form such a hydrogen bond.	Hydrogen	326-334	synemin	Homo sapiens	76-79
8117735-4	1994	Most analogs of guanosine with substituents at C8 have a preference for the syn conformation; however, some C8-substituted analogs have the potential to form a hydrogen bond between the C8 substituent and the 5"-hydroxyl that would stabilize the anti conformation; we have found that analogs with the potential to form such a hydrogen bond are more active substrates than those that cannot form such a hydrogen bond.	Hydrogen	326-334	synemin	Homo sapiens	76-79
7907470-5	1994	The 1H/13C satellite resonances from glutamate C-4 and lactate C-3 in brain tissue were followed from 4 min onwards in the presence of 5 mM [1-13C]glucose.	Hydrogen	4-6	complement C3	Homo sapiens	63-66
35278280-0	2022	Hydrogen-rich and hyperoxygenate saline inhibits lipopolysaccharide-induced lung injury through mediating NF-kappaB/NLRP3 signaling pathway in C57BL/6 mice.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	116-121
35077987-4	2022	Molecular dynamics simulation showed that the binding of myoglobin and pepsin/trypsin was mainly maintained by hydrogen bond and hydrophobicity.	Hydrogen	111-119	myoglobin	Homo sapiens	57-66
8276823-2	1994	Two residues are known to play important catalytic roles in fatty acyl-thioester hydrolase, thioesterase II: Ser-101, the site of a covalent acyl-enzyme intermediate, and His-237 which is within hydrogen bonding distance of Ser-101 and facilitates catalysis by increasing the nucleophilicity of this residue.	Hydrogen	195-203	acyl-CoA thioesterase 8	Homo sapiens	92-107
7718292-3	1994	Abnormal ratio of CD4 and CD3 cells in the allergic nasal epithelium tended to be normal after treatment with H2 antagonist.	Hydrogen	110-112	Cd4 molecule	Rattus norvegicus	18-21
7718292-4	1994	The results of our investigation demonstrated that histamine might cause the number of CD4 and CD8 cells into disorder in allergic nasal mucosal epithelium and the H2 antagonist may be useful in the treatment of allergic rhinitis.	Hydrogen	164-166	Cd4 molecule	Rattus norvegicus	87-90
8111231-1	1993	With the combined use of various two-dimensional (2D) NMR techniques, a complete assignment of the 1H and 13C resonances of oxytocin, Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2, for two molecular states, protonated and unprotonated at the N-terminal group, was performed in dimethyl sulfoxide.	Hydrogen	99-101	oxytocin/neurophysin I prepropeptide	Homo sapiens	124-132
8399158-1	1993	Substitution of cysteine for threonine-199, the amino acid which hydrogen bonds with zinc-bound hydroxide in wild-type carbonic anhydrase II (CAII), leads to the formation of a new His3Cys zinc coordination polyhedron.	Hydrogen	65-73	carbonic anhydrase 2	Homo sapiens	119-140
8399158-1	1993	Substitution of cysteine for threonine-199, the amino acid which hydrogen bonds with zinc-bound hydroxide in wild-type carbonic anhydrase II (CAII), leads to the formation of a new His3Cys zinc coordination polyhedron.	Hydrogen	65-73	carbonic anhydrase 2	Homo sapiens	142-146
8397104-0	1993	1H assignment and secondary structure determination of human melanoma growth stimulating activity (MGSA) by NMR spectroscopy.	Hydrogen	0-2	C-X-C motif chemokine ligand 1	Homo sapiens	99-103
8379930-3	1993	We show that a hydrogen bond to the C-3 position is involved in sugar binding for all three isoforms, but that the direction of this hydrogen bond is different in GLUT 2 from either GLUT 1, 3 or 4.	Hydrogen	133-141	solute carrier family 2 (facilitated glucose transporter), member 1 L homeolog	Xenopus laevis	182-188
8379930-4	1993	Hydrogen-bonding at the C-4 position is also involved in sugar recognition by all three isoforms, but we propose that in GLUT 3 this hydrogen bond plays a less significant role than in GLUT 2 and 4.	Hydrogen	0-8	complement C4A (Rodgers blood group) L homeolog	Xenopus laevis	24-27
8379930-4	1993	Hydrogen-bonding at the C-4 position is also involved in sugar recognition by all three isoforms, but we propose that in GLUT 3 this hydrogen bond plays a less significant role than in GLUT 2 and 4.	Hydrogen	133-141	complement C4A (Rodgers blood group) L homeolog	Xenopus laevis	24-27
7901850-0	1993	Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II.	Hydrogen	58-66	carbonic anhydrase 2	Homo sapiens	89-110
7901850-1	1993	The significance of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in the active site of human carbonic anhydrase II has been examined by X-ray crystallographic analyses of site-specific mutants.	Hydrogen	55-63	carbonic anhydrase 2	Homo sapiens	105-126
8347579-10	1993	From a nonlinear least-squares fit to the steady-state rate equation of data obtained at lipoxygenase concentrations of 0.5 and 1 nM, it was calculated that 1% of the linoleate radicals that are formed after hydrogen abstraction dissociate from the active site before enzymic oxygen insertion has occurred.	Hydrogen	208-216	linoleate 9S-lipoxygenase-4	Glycine max	89-101
8510155-6	1993	In this close encounter the terminal G(10).C(11) base-pair of the symmetry related molecule hydrogen bonds to the G(4).C(17) base-pair forming a novel base-paired G(4)*(G10).C(11)) triplet, where G(4) is hydrogen bonded to both G(10) and C(11).	Hydrogen	92-100	aldo-keto reductase family 1 member C4	Homo sapiens	43-48
8510155-6	1993	In this close encounter the terminal G(10).C(11) base-pair of the symmetry related molecule hydrogen bonds to the G(4).C(17) base-pair forming a novel base-paired G(4)*(G10).C(11)) triplet, where G(4) is hydrogen bonded to both G(10) and C(11).	Hydrogen	92-100	aldo-keto reductase family 1 member C4	Homo sapiens	174-179
8510155-6	1993	In this close encounter the terminal G(10).C(11) base-pair of the symmetry related molecule hydrogen bonds to the G(4).C(17) base-pair forming a novel base-paired G(4)*(G10).C(11)) triplet, where G(4) is hydrogen bonded to both G(10) and C(11).	Hydrogen	92-100	aldo-keto reductase family 1 member C4	Homo sapiens	174-179
8510155-6	1993	In this close encounter the terminal G(10).C(11) base-pair of the symmetry related molecule hydrogen bonds to the G(4).C(17) base-pair forming a novel base-paired G(4)*(G10).C(11)) triplet, where G(4) is hydrogen bonded to both G(10) and C(11).	Hydrogen	204-212	aldo-keto reductase family 1 member C4	Homo sapiens	43-48
8510155-6	1993	In this close encounter the terminal G(10).C(11) base-pair of the symmetry related molecule hydrogen bonds to the G(4).C(17) base-pair forming a novel base-paired G(4)*(G10).C(11)) triplet, where G(4) is hydrogen bonded to both G(10) and C(11).	Hydrogen	204-212	aldo-keto reductase family 1 member C4	Homo sapiens	174-179
8510155-6	1993	In this close encounter the terminal G(10).C(11) base-pair of the symmetry related molecule hydrogen bonds to the G(4).C(17) base-pair forming a novel base-paired G(4)*(G10).C(11)) triplet, where G(4) is hydrogen bonded to both G(10) and C(11).	Hydrogen	204-212	aldo-keto reductase family 1 member C4	Homo sapiens	174-179
8486678-11	1993	The O14 hydroxyls of the intercalated DOXs are within hydrogen bond distances to the O2P atoms of the A2p(aC3) and A8p(AC9) steps.	Hydrogen	54-62	adenylate cyclase 3	Homo sapiens	106-109
9909412-0	1993	Spin-dependent rotational autoionization of H2 Rydberg states.	Hydrogen	44-46	spindlin 1	Homo sapiens	0-4
8467791-4	1993	We have expressed the HMG box region of the B-domain of rat HMG1 (residues 88-164 of the intact protein) in Escherichia coli and we describe here the determination of its structure by 2D 1H-NMR spectroscopy.	Hydrogen	187-189	high mobility group box 1	Rattus norvegicus	60-64
8425681-12	1993	In normal subjects, H2 is consumed by MB or SRB; the activity of these bacteria is virtually absent in PCI.	Hydrogen	20-22	chaperonin containing TCP1 subunit 4	Homo sapiens	44-47
1335516-13	1992	showed that polypeptide amide 1H-2H exchange was greater in the native forms of alpha 1-AT, alpha 1-ACT and C1-INH than in their cleaved forms, whereas for ovalbumin it was unchanged.	Hydrogen	30-32	serpin family A member 3	Homo sapiens	92-103
1335516-13	1992	showed that polypeptide amide 1H-2H exchange was greater in the native forms of alpha 1-AT, alpha 1-ACT and C1-INH than in their cleaved forms, whereas for ovalbumin it was unchanged.	Hydrogen	30-32	serpin family G member 1	Homo sapiens	108-114
1336460-1	1992	The structures of human carbonic-anhydrase-II complexes with the anionic inhibitors hydrogen sulphide (HS-) and nitrate (NO3-) have been determined by X-ray diffraction at 0.19-nm resolution from crystals soaked at pH 7.8 and 6.0, respectively.	Hydrogen	103-106	carbonic anhydrase 2	Homo sapiens	24-45
1472646-5	1992	Based on this comparison and analysis of restrained molecular dynamics trajectories, we found that, although the turns are stabilized by the formation of hydrogen bonds, the oxytocin molecule possesses a slight twist in DMSO solution relative to the orientation of deamino-oxytocin in the crystalline state.	Hydrogen	154-162	oxytocin/neurophysin I prepropeptide	Homo sapiens	174-182
1429698-5	1992	Two of the eight ordered waters in I-FABP:oleate are part of a hydrogen bond network that includes the carboxylate of oleate, the guanidinium group of Arg106, the nitrogen of the indole group of Trp82, and the side chain of Gln115.	Hydrogen	63-71	fatty acid binding protein 2	Rattus norvegicus	35-41
1453468-0	1992	Solution structures of two zinc-finger domains from SWI5 obtained using two-dimensional 1H nuclear magnetic resonance spectroscopy.	Hydrogen	88-90	DNA-binding transcription factor SWI5	Saccharomyces cerevisiae S288C	52-56
9908883-0	1992	Spin coupling constants and hyperfine transition frequencies for the hydrogen molecular ion.	Hydrogen	69-77	spindlin 1	Homo sapiens	0-4
1383552-1	1992	A high-quality three-dimensional structure of the bovine pancreatic trypsin inhibitor (BPTI) in aqueous solution was determined by 1H nuclear magnetic resonance (n.m.r.)	Hydrogen	131-133	spleen trypsin inhibitor I	Bos taurus	87-91
1335996-3	1992	The results of the solution conformational analysis, performed by using Fourier transform infrared absorption and 1H nuclear magnetic resonance, indicate that in chloroform the -Aib-D-Tic-Aib-, -(Aib)2-D-Tic-(Aib)2-, and -L-Pro-D-Tic- sequences fold into intramolecularly H-bonded forms to a great extent.	Hydrogen	114-116	ANIB1	Homo sapiens	178-181
1335996-3	1992	The results of the solution conformational analysis, performed by using Fourier transform infrared absorption and 1H nuclear magnetic resonance, indicate that in chloroform the -Aib-D-Tic-Aib-, -(Aib)2-D-Tic-(Aib)2-, and -L-Pro-D-Tic- sequences fold into intramolecularly H-bonded forms to a great extent.	Hydrogen	114-116	ANIB1	Homo sapiens	188-191
1335996-3	1992	The results of the solution conformational analysis, performed by using Fourier transform infrared absorption and 1H nuclear magnetic resonance, indicate that in chloroform the -Aib-D-Tic-Aib-, -(Aib)2-D-Tic-(Aib)2-, and -L-Pro-D-Tic- sequences fold into intramolecularly H-bonded forms to a great extent.	Hydrogen	114-116	ANIB1	Homo sapiens	188-191
1335996-3	1992	The results of the solution conformational analysis, performed by using Fourier transform infrared absorption and 1H nuclear magnetic resonance, indicate that in chloroform the -Aib-D-Tic-Aib-, -(Aib)2-D-Tic-(Aib)2-, and -L-Pro-D-Tic- sequences fold into intramolecularly H-bonded forms to a great extent.	Hydrogen	114-116	ANIB1	Homo sapiens	188-191
1331570-4	1992	In bone-resorbing osteoclasts, hydrogen ions are provided by carbonic anhydrase II, which catalyzes the hydration of CO2 to H2CO3.	Hydrogen	31-39	carbonic anhydrase 2	Homo sapiens	61-82
10004215-0	1992	Trap-limited hydrogen diffusion in a-Si:H.	Hydrogen	13-21	TRAP	Homo sapiens	0-4
1639779-8	1992	Examination of the rat DHPR sequence shows a typical dinucleotide binding fold with Asp-37 located precisely in the position predicted for the acidic residue that participates in hydrogen bond formation with the 2"-hydroxyl moiety of all known NAD-dependent dehydrogenases.	Hydrogen	179-187	quinoid dihydropteridine reductase	Rattus norvegicus	23-27
1391721-1	1992	The effect of interleukin-1 alpha (IL-1) on the synthesis of glomerular basement membrane heparan sulfate-proteoglycan (HS-PG) was investigated.	Hydrogen	120-122	CD44 molecule (Indian blood group)	Homo sapiens	90-118
1304906-7	1992	Increasing the hydrogen ion concentration resulted in a 25% decrease in beta-NGF stability at pH 4 relative to pH 7.	Hydrogen	15-23	nerve growth factor	Mus musculus	72-80
1751485-0	1991	1H NMR studies of DNA recognition by the glucocorticoid receptor: complex of the DNA binding domain with a half-site response element.	Hydrogen	0-2	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	41-64
1751485-1	1991	The complex of the rat glucocorticoid receptor (GR) DNA binding domain (DBD) and half-site sequence of the consensus glucocorticoid response element (GRE) has been studied by two-dimensional 1H NMR spectroscopy.	Hydrogen	191-193	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	23-46
1751485-1	1991	The complex of the rat glucocorticoid receptor (GR) DNA binding domain (DBD) and half-site sequence of the consensus glucocorticoid response element (GRE) has been studied by two-dimensional 1H NMR spectroscopy.	Hydrogen	191-193	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	48-50
1939111-6	1991	The hydrogen atom at C-3 of the enzyme product is introduced from solvent water.	Hydrogen	4-12	complement C3	Homo sapiens	21-24
1833238-1	1991	It has been shown by scanning calorimetry and 1H NMR spectroscopy that thermal denaturation of mutant lambda phage cro repressor in which Val55 was substituted for Cys, proceeds in 2 stages in contrast to the wild type protein.	Hydrogen	46-48	cro	Escherichia virus Lambda	115-118
29667813-10	2018	1H NMR studies and DFT calculations indicate that Hg2+ ions coordinate to oxygen-donor atoms from both the chromophore and macrocycle, leading to sensitive mercury detection.	Hydrogen	0-2	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	50-53
28548030-6	2018	UGT1A3 and UGT2B7 were selected to elucidate the inhibition mechanism, and in silico docking showed that hydrogen bonds and hydrophobic interactions mainly contributed to the strong binding of everolimus toward the activity cavity of UGT1A3 and UGT2B7.	Hydrogen	105-113	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	234-240
28548030-6	2018	UGT1A3 and UGT2B7 were selected to elucidate the inhibition mechanism, and in silico docking showed that hydrogen bonds and hydrophobic interactions mainly contributed to the strong binding of everolimus toward the activity cavity of UGT1A3 and UGT2B7.	Hydrogen	105-113	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	245-251
29632183-8	2018	The binding of OR1A1 to nitromusks is stabilized by hydrogen bonding to Tyr258 along with hydrophobic interactions with surrounding aromatic residues Tyr251 and Phe206.	Hydrogen	52-60	olfactory receptor family 1 subfamily A member 1	Homo sapiens	15-20
29671827-7	2018	CoMFA/CoMSIA contour maps demonstrated that bulky substitutions and hydrogen-bond donors were preferred at R1 and 1-position, respectively, and introducing hydrophilic substitutions at R1 and R4 was important for improving BTK inhibitory activities.	Hydrogen	68-76	Bruton tyrosine kinase	Homo sapiens	223-226
29850087-7	2018	Stacks of alternating layers consisting of either anti or syn isomers, formed with the aid of the hydrogen bonding, are observed.	Hydrogen	98-106	synemin	Homo sapiens	58-61
29461882-7	2018	HOPE and SWISS PDB viewer showed that SALL4-R418C leads to changes in amino acid properties, loss of protein hydrogen bond, and functional impact of SALL4 zinc finger domain.	Hydrogen	109-117	spalt like transcription factor 4	Homo sapiens	38-43
29327466-5	2018	In the present work, trace levels of hydrogen isotopes (~100 ppm of H2 and D2 ) have been analyzed with a Zeolite 5A and a modified gamma-Al2 O3 column.	Hydrogen	37-45	relaxin 2	Homo sapiens	68-77
29546256-4	2018	In addition, the syn form gemini surfactant forms micelles with a close packing of the headgroups via hydrogen bonding.	Hydrogen	102-110	synemin	Homo sapiens	17-20
29546256-6	2018	We propose that, for the syn form gemini surfactant, the closer packing of the headgroups as well as the hydrogen bonding network around the micelle interface prevent water penetration into the hydrophobic part of the micelle.	Hydrogen	105-113	synemin	Homo sapiens	25-28
29587421-4	2018	Among all the samples, the 3 at.% Ag-doped SnO2 showed the highest response 39 to 100 muL/L H2 at 300  C. Moreover, its gas sensing mechanism was discussed, and the results will provide reference and theoretical guidance for the development of high-performance SnO2-based H2 sensing devices.	Hydrogen	92-94	strawberry notch homolog 2	Homo sapiens	43-46
29587421-4	2018	Among all the samples, the 3 at.% Ag-doped SnO2 showed the highest response 39 to 100 muL/L H2 at 300  C. Moreover, its gas sensing mechanism was discussed, and the results will provide reference and theoretical guidance for the development of high-performance SnO2-based H2 sensing devices.	Hydrogen	272-274	strawberry notch homolog 2	Homo sapiens	43-46
29378849-6	2018	The C-terminal PDZ-binding motif of Gukh is located in the canonical ligand-binding groove of Scrib PDZ1 and utilizes an unusually extensive network of hydrogen bonds and ionic interactions to enable binding to PDZ1 with high affinity.	Hydrogen	152-160	GUK-holder	Drosophila melanogaster	36-40
29378849-6	2018	The C-terminal PDZ-binding motif of Gukh is located in the canonical ligand-binding groove of Scrib PDZ1 and utilizes an unusually extensive network of hydrogen bonds and ionic interactions to enable binding to PDZ1 with high affinity.	Hydrogen	152-160	scribble	Drosophila melanogaster	94-99
29494164-8	2018	A clear tunneling splitting is observed for the torsional motion of the two hydrogen molecules ( pH2, HD, or oD2) on a ring about the OCS molecular axis, whereas no tunneling splitting is found in OCS- pH2-He or OCS-(He)2 due to a much lower torsional barrier.	Hydrogen	76-84	polyhomeotic homolog 2	Homo sapiens	97-100
29568538-17	2018	Hydrogen gas inhalation markedly upregulated the activity of decreased superoxide dismutase and significantly attenuated the increased level of malondialdehyde and myeloperoxidase.	Hydrogen	0-8	myeloperoxidase	Mus musculus	164-179
29546582-6	2018	A18 formed seven hydrogen bonds (H-bonds) at residues Arg292, Arg371, Asp151, Trp178, Glu227, and Tyr406, while eight H-bonds were formed by OTV with amino acids Arg118, Arg292, Arg371, Glu119, Asp151, and Arg152.	Hydrogen	17-25	immunoglobulin kappa variable 2-29	Homo sapiens	0-3
29546582-8	2018	Our simulation study showed that the A18-NA complex is as stable as the OTV-NA complex during the MD simulation of 50 ns through the analysis of RMSD, RMSF, total energy, hydrogen bonding, and MM/PBSA free energy calculations.	Hydrogen	171-179	immunoglobulin kappa variable 2-29	Homo sapiens	37-40
1920401-8	1991	This mechanism enables DNA molecules resident in the presynaptic RecA-DNA complexes to be exposed for hydrogen bond formation with DNA molecules contacting the presynaptic RecA-DNA filament.	Hydrogen	102-110	RAD51 recombinase	Homo sapiens	65-69
1920401-8	1991	This mechanism enables DNA molecules resident in the presynaptic RecA-DNA complexes to be exposed for hydrogen bond formation with DNA molecules contacting the presynaptic RecA-DNA filament.	Hydrogen	102-110	RAD51 recombinase	Homo sapiens	172-176
1931813-5	1991	Accordingly, the interactions between the MHC molecule and the peptide antigen appear to be essentially mediated by hydrophobic interactions and hydrogen bonding, while electrostatic interactions between charged residues might be important in the association of TCR and MHC molecules.	Hydrogen	145-153	major histocompatibility complex, class I, C	Homo sapiens	42-45
10045004-0	1991	Direct evidence for localized motion of hydrogen in Cd-H complexes in silicon.	Hydrogen	40-48	choline dehydrogenase	Homo sapiens	52-56
35609118-2	2022	The reactions featured low catalyst loading, high selectivity, wide substrate scope, and good yields, with only water and hydrogen gas (H2) as the byproducts.	Hydrogen	122-130	gastrin	Homo sapiens	131-134
29540697-6	2018	Kaempferol forms hydrogen bonds with the FGFR3 backbone oxygen of Glu555 and Ala558 and the side chain of Lys508.	Hydrogen	17-25	fibroblast growth factor receptor 3	Homo sapiens	41-46
1904222-3	1991	H2-antagonists stimulated tyrosinase activity and melanin accumulation in B16-C3 cells in a dose- and time-dependent manner.	Hydrogen	0-2	tyrosinase	Homo sapiens	26-36
35158192-6	2022	The optimized ZnS@SnS2/CdS hybrid exhibits a CO generation rate of 155.57 mumol g-1h-1 and an excellent selectivity of 80.4%.	Hydrogen	82-84	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
35616778-3	2022	In this study, to analyze the function and structure of GPx4 by solution NMR, we performed resonance assignments of GPx4 and assigned almost all backbone 1H, 13C, and 15N resonances and most of the side chain 1H and 13C resonances.	Hydrogen	154-156	glutathione peroxidase 4	Homo sapiens	56-60
1830036-4	1991	infusion of hANF (bolus 100 micrograms; infusion 100 micrograms/h, t = 1h) arterial and venous plasma concentrations of hANF increased about 10-fold (p less than 0.05), however, estimated leg blood flow as well as leg fractional extraction, leg uptake and clearance rates of hANF did not significantly change as compared to baseline.	Hydrogen	71-73	HESX homeobox 1	Homo sapiens	120-124
1830036-4	1991	infusion of hANF (bolus 100 micrograms; infusion 100 micrograms/h, t = 1h) arterial and venous plasma concentrations of hANF increased about 10-fold (p less than 0.05), however, estimated leg blood flow as well as leg fractional extraction, leg uptake and clearance rates of hANF did not significantly change as compared to baseline.	Hydrogen	71-73	HESX homeobox 1	Homo sapiens	120-124
29498652-4	2018	The Pd/alk-Ti3C2X2 catalyst shows excellent catalytic activity for the hydrodechlorination of 4-chlorophenol and the hydrogenation of 4-nitrophenol in aqueous solution at 25  C and hydrogen balloon pressure.	Hydrogen	117-125	ALK receptor tyrosine kinase	Homo sapiens	7-10
29339381-7	2018	These effects have functional consequences as CCK-8 was found to promote the uptake of dietary fatty acids by WAT, as demonstrated by means of proton nuclear magnetic resonance (1H-NMR).	Hydrogen	178-180	cholecystokinin	Rattus norvegicus	46-49
1991121-10	1991	The energy-minimized conformation of the central d(A6-oxo-G7-T8).d(A17-A18-T19) segment requires that the 8-oxo-7H-dG7(syn).dA18(anti) alignment be stabilized by two hydrogen bonds from NH7 and O6 of 8-oxo-7H-dG7(syn) to N1 and NH2-6 of dA18(anti), respectively, at the lesion site.	Hydrogen	166-174	synemin	Homo sapiens	119-122
35616778-3	2022	In this study, to analyze the function and structure of GPx4 by solution NMR, we performed resonance assignments of GPx4 and assigned almost all backbone 1H, 13C, and 15N resonances and most of the side chain 1H and 13C resonances.	Hydrogen	209-211	glutathione peroxidase 4	Homo sapiens	56-60
1991121-10	1991	The energy-minimized conformation of the central d(A6-oxo-G7-T8).d(A17-A18-T19) segment requires that the 8-oxo-7H-dG7(syn).dA18(anti) alignment be stabilized by two hydrogen bonds from NH7 and O6 of 8-oxo-7H-dG7(syn) to N1 and NH2-6 of dA18(anti), respectively, at the lesion site.	Hydrogen	166-174	synemin	Homo sapiens	213-216
29106682-7	2018	Molecular docking analysis revealed that key hydrogen bonds were formed by nitrogen atoms of the imidazole bond with Val440 of CFTR and Ala697 of the SLC26 family.	Hydrogen	45-53	cystic fibrosis transmembrane conductance regulator	Mus musculus	127-131
35631399-6	2022	Subsequently, binding modes of these ligands are obtained using a model of H3R by docking and molecular dynamics studies, thus determining the importance of the purine ring in enhancing affinity due to the hydrogen bonding of Tyr374 to the N-7 of this heterocycle.	Hydrogen	206-214	histamine receptor H3	Homo sapiens	75-78
29300467-0	2018	Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant.	Hydrogen	10-18	heat shock protein family A (Hsp70) member 8	Homo sapiens	67-72
1989879-1	1991	The three-dimensional structure of the activation domain isolated from porcine pancreatic procarboxypeptidase B was determined using 1H NMR spectroscopy.	Hydrogen	133-135	carboxypeptidase B1	Homo sapiens	90-111
29293359-5	2018	The systematic displacement of CdX2 from the surface by N,N,N",N"-tetramethylethylene-1,2-diamine (TMEDA) has been studied using a combination of 1H NMR and photoluminescence spectroscopies.	Hydrogen	146-148	caudal type homeobox 2	Homo sapiens	31-35
35262982-6	2022	In this study, a high-performance N,Cu-CoP/carbon cloth (CC) catalyst was synthesized to catalyze the cathodic hydrogen evolution reaction (HER) at an especially low overpotential of 64.7 mV at 10 mA cm-2 .	Hydrogen	111-119	caspase recruitment domain family member 16	Homo sapiens	39-42
1896431-5	1991	The significance of some changes in the catalytic site is uncertain due to the intrusion of a symmetry related Lys-70 side chain which hydrogen bonds to both Asp-21 and Glu-43.	Hydrogen	135-143	beta-secretase 2	Homo sapiens	158-164
29266417-3	2018	Cu3 P@NPPC demonstrates outstanding activity for both the hydrogen evolution and oxygen reduction reaction, representing the first example of a Cu3 P-based bifunctional catalyst for energy-conversion reactions.	Hydrogen	58-66	natriuretic peptide C	Homo sapiens	0-10
35420771-5	2022	The unique gas adsorption properties of PLs are based on their structure, which exhibits multiple gas binding sites in the pore and on the cage surface, varying binding mechanisms including hydrogen-bonding and pi-pi interactions, and selective diffusion in the solvent.	Hydrogen	190-198	gastrin	Homo sapiens	11-14
29421020-5	2018	The primary endpoint was the difference in high-sensitive Troponin I (hs-cTnI) and -T (hs-cTnT) measured 2 hours before and 4 hours after cardioversion.	Hydrogen	70-72	troponin I3, cardiac type	Homo sapiens	73-77
2118902-3	1990	The dual specificity considered here is typified by the oxygenation of arachidonic acid by the reticulocyte lipoxygenase: two chiral products are formed (12S- and 15S-hydroperoxides, ratio approximately 1:9) via hydrogen abstraction from two separate methylene groups (C-10 and C-13).	Hydrogen	212-220	linoleate 9S-lipoxygenase-4	Glycine max	108-120
2133096-6	1990	It is proposed that the syn conformation of these oxidized bases in duplex DNA and RNA can be further stabilized by abnormal hydrogen bonding or mispairing that involves N7-H.	Hydrogen	125-133	synemin	Homo sapiens	24-27
35460557-6	2022	RESULTS: 1H-MRS revealed that lactate and glutathione (GSH) were the most significantly altered metabolites when either TERT or GABPB1 was silenced, and lactate and GSH levels were correlated with cellular TERT expression.	Hydrogen	9-11	telomerase reverse transcriptase	Homo sapiens	120-124
1697463-0	1990	The detection of proline isomerase activity in FK506-binding protein by two-dimensional 1H NMR exchange spectroscopy.	Hydrogen	88-90	FKBP prolyl isomerase 2	Homo sapiens	17-34
35387450-3	2022	Iron catalysts are utilized to accelerate the reaction, but high temperatures and pressures of atmospheric nitrogen gas (N2) and hydrogen gas (H2) are required.	Hydrogen	129-137	gastrin	Homo sapiens	138-141
1974931-3	1990	From computer graphics analysis and MD simulations on the zinc hydroxide form of human carbonic anhydrase II we find that this interaction forces the hydroxide hydrogen atom to be in a "down" position relative to the deep water-binding pocket.	Hydrogen	160-168	carbonic anhydrase 2	Homo sapiens	87-108
29051098-5	2018	Molecular docking studies revealed a decreased binding affinity of substrate, Platelet Activating Factor (PAF) with the nitrated forms of Lp-PLA2 (NT-Tyr307 and NT-Tyr335) compared to the wild type, due to differences in the hydrogen bond interaction patterns.	Hydrogen	225-233	phospholipase A2 group VII	Homo sapiens	138-145
35285467-3	2022	To reconstruct the ECM of a diabetic patient"s wound, in this work, we designed a pH-responsive "Double H-bonds" (hydrogen bond and hydrazone bond) hyaluronic acid-collagen hydrogel.	Hydrogen	114-122	multimerin 1	Homo sapiens	19-22
28983974-5	2018	Structural analysis revealed that peptide N-terminus and hydrogen bonds play important roles in the peptide interaction stability and specificity with Brd2 and Brd4.	Hydrogen	57-65	bromodomain containing 2	Homo sapiens	151-155
28632510-12	2018	In addition, H2 alleviates ALI in septic mice through downregulating the expression of Sema 7A, OTULIN, and MAP3K1 as well as upregulating the expression of Transferrin.	Hydrogen	13-15	OTU deubiquitinase with linear linkage specificity	Mus musculus	96-102
1696255-5	1990	synthase was incubated with L-arginine, NADPH, tetrahydrobiopterin, FAD, and dithiothreitol in H2(18)/16O2.	Hydrogen	95-97	2,4-dienoyl-CoA reductase 1	Homo sapiens	40-45
35458714-8	2022	Molecular docking and MD simulation revealed that BA bound to the active site of alpha-glucosidase mainly due to the van der Waals force and hydrogen bond, and then changed the micro-environment and secondary structure of alpha-glucosidase.	Hydrogen	141-149	sucrase isomaltase (alpha-glucosidase)	Mus musculus	81-98
2372316-18	1990	The few NOE crosspeaks, pH dependence, and Cu2+ broadening of C9 1H signals indicate an isolated location accessible to solvent.	Hydrogen	65-67	complement C9	Homo sapiens	62-64
2166565-0	1990	Ca2+ binding to calbindin D9k strongly affects backbone dynamics: measurements of exchange rates of individual amide protons using 1H NMR.	Hydrogen	131-133	carbonic anhydrase 2	Homo sapiens	0-3
2166565-1	1990	One- and two-dimensional 1H NMR have been used to study the backbone dynamics in Ca2(+)-free (apo) and Ca2(+)-loaded (Ca2) calbindin D9k at pH 7.5 and 25 degrees C. Hydrogen exchange rates of all 71 backbone amide protons (NH"s) have been measured for the Ca2 form by both a direct exchange-out experiment and another experiment that measures the transfer of saturation from water protons to amide protons.	Hydrogen	165-173	carbonic anhydrase 2	Homo sapiens	81-88
28632510-12	2018	In addition, H2 alleviates ALI in septic mice through downregulating the expression of Sema 7A, OTULIN, and MAP3K1 as well as upregulating the expression of Transferrin.	Hydrogen	13-15	transferrin	Mus musculus	157-168
35176335-2	2022	The chloride anions form NH   Cl- hydrogen bonds in BCl-4ABA and OH   Cl- hydrogen bonds in BCl-4HBA.	Hydrogen	34-42	BCL3 transcription coactivator	Homo sapiens	52-57
29191828-0	2018	Hydrogen-deuterium exchange reveals long-range dynamical allostery in soybean lipoxygenase.	Hydrogen	0-8	linoleate 9S-lipoxygenase-4	Glycine max	78-90
29191828-5	2018	Herein, we employed hydrogen-deuterium exchange MS (HDXMS) to spatially resolve changes in protein conformation upon interaction of soybean lipoxygenase with a fatty acid surrogate, oleyl sulfate (OS), previously shown to act at a site separate from the substrate-binding site.	Hydrogen	20-28	linoleate 9S-lipoxygenase-4	Glycine max	140-152
29297671-0	2018	Kinetic Isotope Effect Determination Probes the Spin of the Transition State, Its Stereochemistry, and Its Ligand Sphere in Hydrogen Abstraction Reactions of Oxoiron(IV) Complexes.	Hydrogen	124-132	spindlin 1	Homo sapiens	48-52
29299549-4	2018	The same LP-MIR measurements, on the basis of a semi-empirical relation and of geometrical considerations and assumptions, allowed calculation of the -CNH-O- hydrogen bond length along the a and b axes of the crystal.	Hydrogen	158-166	membrane associated ring-CH-type finger 8	Homo sapiens	12-15
2166565-3	1990	The results for the Ca2 form are related to solvent accessibility and hydrogen bonding obtained in molecular dynamics simulations of calcium-loaded calbindin.	Hydrogen	70-78	carbonic anhydrase 2	Homo sapiens	20-23
2166565-6	1990	This experiment is applicable to all amide hydrogens that exchange slowly in the Ca2 form.	Hydrogen	43-52	carbonic anhydrase 2	Homo sapiens	81-84
2166565-9	1990	Hydrogen bonds involving backbone NH"s in the Ca2+ loops appear to be broken or weakened when calbindin releases Ca2+, whereas the beta-sheet between the Ca2+ loops is found to be present in both the Ca2 and apo forms.	Hydrogen	0-8	carbonic anhydrase 2	Homo sapiens	46-49
2166565-9	1990	Hydrogen bonds involving backbone NH"s in the Ca2+ loops appear to be broken or weakened when calbindin releases Ca2+, whereas the beta-sheet between the Ca2+ loops is found to be present in both the Ca2 and apo forms.	Hydrogen	0-8	carbonic anhydrase 2	Homo sapiens	113-116
2166565-9	1990	Hydrogen bonds involving backbone NH"s in the Ca2+ loops appear to be broken or weakened when calbindin releases Ca2+, whereas the beta-sheet between the Ca2+ loops is found to be present in both the Ca2 and apo forms.	Hydrogen	0-8	carbonic anhydrase 2	Homo sapiens	113-116
2166565-9	1990	Hydrogen bonds involving backbone NH"s in the Ca2+ loops appear to be broken or weakened when calbindin releases Ca2+, whereas the beta-sheet between the Ca2+ loops is found to be present in both the Ca2 and apo forms.	Hydrogen	0-8	carbonic anhydrase 2	Homo sapiens	113-116
35170133-2	2022	To address this issue, a series of cyclometalated Ir(III) complexes ( Ir1 - Ir5 ), featuring different electron-donating substituents to enhance the absorptivity, have been synthesized and studied as photosensitizers (PSs) for light-driven hydrogen production from water.	Hydrogen	240-248	nischarin	Homo sapiens	70-73
2379749-0	1990	1H-nuclear magnetic resonance conformational studies on synthetic analogues of gastrin-releasing peptide.	Hydrogen	0-2	gastrin releasing peptide	Homo sapiens	79-104
29311706-4	2018	Molecular dynamics simulation of PHF6 oligomers and fibrils with the Naphthoquinone-Tryptophan hybrids provides a possible structure-function based mechanism-of-action, highlighting the role of hydrophobic interaction and hydrogen bond formation during fibril disassembly.	Hydrogen	222-230	PHD finger protein 6	Homo sapiens	33-37
35409252-6	2022	The complex structures revealed that these inhibitors formed an extra hydrogen bond to AF9, with respect to known ENL inhibitors.	Hydrogen	70-78	MLLT1 super elongation complex subunit	Homo sapiens	114-117
2177661-8	1990	The hydrogen-bonding scheme predicted for the 2"-GMP (C2"-endo)-RNase T1 complex agrees well with those reported from x-ray crystallographic studies.	Hydrogen	4-12	5'-nucleotidase, cytosolic II	Homo sapiens	49-52
35369091-5	2022	Molecular docking showed that hydrogen bonds were the main driving force in the interaction between the peptide DLGFLARGF and tyrosinase.	Hydrogen	30-38	tyrosinase	Mus musculus	126-136
2224052-3	1990	The two antiparallel extended strands are stabilized by two hydrogen bonds between the Boc CO and Ala NH groups [N...O 2.964 (3) A, O...HN 2.11 (3) A, and NH...O angle 162 (3) degrees].	Hydrogen	60-68	BOC cell adhesion associated, oncogene regulated	Homo sapiens	87-90
29109150-5	2018	Furthermore, hydrogen-deuterium exchange coupled with mass spectrometry showed that mutation of Asp21 promoted disorder in the N-terminal helices of 14-3-3zeta, suggesting that this residue plays an important role in maintaining structure across the dimer interface.	Hydrogen	13-21	beta-secretase 2	Homo sapiens	96-101
29109150-5	2018	Furthermore, hydrogen-deuterium exchange coupled with mass spectrometry showed that mutation of Asp21 promoted disorder in the N-terminal helices of 14-3-3zeta, suggesting that this residue plays an important role in maintaining structure across the dimer interface.	Hydrogen	13-21	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	149-159
35372522-7	2022	We demonstrated that epigallocatechin gallate (EGCG) form inter-molecular hydrogen bonds with each of IAPP and Abeta40.	Hydrogen	74-82	islet amyloid polypeptide	Rattus norvegicus	102-106
31258285-3	2018	Excess H2 consumption during TPR is indicative of partial support reduction, which was confirmed by O2 titration.	Hydrogen	7-9	translocated promoter region, nuclear basket protein	Homo sapiens	29-32
2306786-11	1990	Calculations using molecular mechanics, MM2(87), show that in natural cerebroside the intramolecular hydrogen bond stabilizes the theta 1 = -syn-clinal conformation about the C(1)--C(2) sphingosine bond by 2-2.5 kcal/mol compared to other staggered conformations.	Hydrogen	101-109	PNMA family member 2	Homo sapiens	40-43
35232968-4	2022	Combining of DRIFTS, AP-XPS, EXAFS, and DFT calculations, we show that the Pt1/CeO2 catalyst exhibits a super-synergistic effect between the catalytic Pt atom and its support, involving redox coupling between Pt and Ce ions, enabling adsorption, activation and reaction of large molecules with sufficient versatility to drive abstraction/addition of hydrogen without requiring multiple reaction sites.	Hydrogen	350-358	zinc finger protein 77	Homo sapiens	75-83
33810482-6	2021	Molecular dynamics simulations predicted that the dinucleotide substitution alters structural dynamics, fold, and hydrogen-bond networks primarily of the psi-SL2 element that contains the binding interface of viral nucleocapsid protein for the genome packaging.	Hydrogen	114-122	matrix metallopeptidase 10	Homo sapiens	158-161
33807119-5	2021	Lineweaver-Burk analysis confirmed the non-competitive inhibition pattern of KNFL, and molecular docking showed that it bound at a non-active site of ACE via hydrogen bonds.	Hydrogen	158-166	angiotensin-converting enzyme	Sus scrofa	150-153
33808657-5	2021	Here, we report the interaction site between an ANXA1-specific antibody known to inhibit T cell activation without adverse cytotoxic effects and ANXA1 using amide hydrogen-deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	163-171	annexin A1	Homo sapiens	48-53
33808657-5	2021	Here, we report the interaction site between an ANXA1-specific antibody known to inhibit T cell activation without adverse cytotoxic effects and ANXA1 using amide hydrogen-deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	163-171	annexin A1	Homo sapiens	145-150
24750035-3	2015	EXPERIMENTAL APPROACH: H2 S biosynthesis was evaluated in rat isolated aortic rings following androgen receptor (NR3C4) stimulation.	Hydrogen	23-25	androgen receptor	Rattus norvegicus	94-111
34970349-12	2022	In addition the protein expression levels of RIP1 and RIP3 and the cytokines NF-kappaB, TNF-alpha, IL-1beta and IL-6 were downregulated compared with the TBI group, which demonstrated that hydrogen-rich saline-induced inhibition of necroptosis and neuroinflammation ameliorated neuronal death following TBI.	Hydrogen	189-197	receptor-interacting serine-threonine kinase 3	Mus musculus	54-58
34780780-3	2022	With hydrogen-deuterium exchange mass spectrometry (HDX-MS), slow unfolding/refolding kinetics were identified in multiple regions of LeuT, suggesting that substrate translocation involves cooperative fluctuations of helical stretches.	Hydrogen	5-13	Leucine transport, high	Homo sapiens	134-138
34962125-2	2022	These include (i) nonadiabatic switching of spin quantization axis due to residual background fields and (ii) scalar pathways due to through-bond couplings between 1H and heteronuclear spin species, such as 2H used partially as an isotopic substitute for 1H.	Hydrogen	164-166	spindlin 1	Homo sapiens	44-48
34962125-2	2022	These include (i) nonadiabatic switching of spin quantization axis due to residual background fields and (ii) scalar pathways due to through-bond couplings between 1H and heteronuclear spin species, such as 2H used partially as an isotopic substitute for 1H.	Hydrogen	164-166	spindlin 1	Homo sapiens	185-189
34962125-2	2022	These include (i) nonadiabatic switching of spin quantization axis due to residual background fields and (ii) scalar pathways due to through-bond couplings between 1H and heteronuclear spin species, such as 2H used partially as an isotopic substitute for 1H.	Hydrogen	255-257	spindlin 1	Homo sapiens	185-189
34774546-1	2022	In this work, new thiosemicarbazides (ECA-1, ECA-2) and their Cu (II) complexes (ECA-1-Cu, ECA-2-Cu) were synthesized and their structures were characterized by 1H NMR, 13C NMR, FT-IR, LC-MS, UV-Vis, and thermogravimetric analysis methods.	Hydrogen	161-163	gamma-aminobutyric acid type A receptor subunit gamma2	Homo sapiens	45-50
34774546-1	2022	In this work, new thiosemicarbazides (ECA-1, ECA-2) and their Cu (II) complexes (ECA-1-Cu, ECA-2-Cu) were synthesized and their structures were characterized by 1H NMR, 13C NMR, FT-IR, LC-MS, UV-Vis, and thermogravimetric analysis methods.	Hydrogen	161-163	gamma-aminobutyric acid type A receptor subunit gamma2	Homo sapiens	91-96
34889907-3	2021	The new probes (P1 and P2) were fully characterized by analytical, NMR spectroscopy (1H and 13C), and ESI mass spectrometry.	Hydrogen	85-87	crystallin gamma F, pseudogene	Homo sapiens	16-25
34908056-4	2021	The dynamics are controlled by addition to the carbon-carbon triple bond with the reaction intermediates eventually eliminating a hydrogen atom from the methyl groups of the dimethylacetylene reactant forming 1-methyl-3-methylenecyclopropene (p28).	Hydrogen	130-138	golgi SNAP receptor complex member 1	Homo sapiens	243-246
34346532-4	2021	However, the orbital alignment in the syn conformer is less favorable for the hydrogen transfer reaction than the orbital configuration in the anti conformer.	Hydrogen	78-86	synemin	Homo sapiens	38-41
34375870-4	2021	This paper provides a comprehensive review, including: (1) The impact of pollutants such as NOX, SOX, CO2 and PM emitted by ships on the environment and human health; (2) New regulations about ship exhaust emissions; (3) Application of clean energy such as LNG, biodiesel, methanol, hydrogen and ammonia on ships; (4) After-treatment technology of ship exhaust gas such as SCR and EGR.	Hydrogen	283-291	inositol polyphosphate-5-phosphatase D	Homo sapiens	348-352
34825673-1	2021	Hydrogen bonding in liquids of the constitution isomers of heptan-1-ol mixed with 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ionic liquids (ILs), (Cnmim)(NTf2), is investigated using both computational and experimental techniques.	Hydrogen	0-8	nuclear transport factor 2	Homo sapiens	173-177
30569858-4	2018	The steric, electrostatic, hydrophobic and hydrogen bond acceptor interactions have been found important in describing the variation in human SIRT1 activation.	Hydrogen	43-51	sirtuin 1	Homo sapiens	142-147
29128116-10	2018	The results reveal that compounds 24 and 27 form more hydrogen bonds to EphA2 than Doxazosin, suggesting that they may have higher binding affinity to the receptor.	Hydrogen	54-62	EPH receptor A2	Homo sapiens	72-77
29768852-5	2018	Spin state switching between LS and HS is clearly revealed by the hysteresis loop observed in the temperature dependence of the electrical conductivity in its heating and cooling cycle.	Hydrogen	36-38	spindlin 1	Homo sapiens	0-4
28585088-7	2018	The binding efficacy of AITC with AhR and Nrf2 analysis by molecular docking studies reveals that AITC has strong interaction with AhR and Nrf2 proteins through hydrogen and hydrophobic interactions.	Hydrogen	161-169	aryl hydrocarbon receptor	Rattus norvegicus	131-134
28585088-7	2018	The binding efficacy of AITC with AhR and Nrf2 analysis by molecular docking studies reveals that AITC has strong interaction with AhR and Nrf2 proteins through hydrogen and hydrophobic interactions.	Hydrogen	161-169	aryl hydrocarbon receptor	Rattus norvegicus	34-37
28738528-7	2017	Mutation of sod-2, sod-3, or aak-2 further suppressed the recovery effect of simulated microgravity toxicity in nematodes after simulated microgravity treatment for 1h.	Hydrogen	165-167	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	12-17
29066623-6	2017	Gln-282 contributed to sugar binding in all GLUT1 conformations via hydrogen bonding.	Hydrogen	68-76	solute carrier family 2 member 1	Homo sapiens	44-49
29166011-8	2017	Hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS) was used to investigate differences in the solvent accessibility of the peptide backbone in the intermediate and native forms of dPGM.	Hydrogen	0-8	Phosphoglucose mutase 1	Drosophila melanogaster	197-201
28982678-10	2017	In contrast, the deletion of residue p.Lys164 (or p.Arg196del in Bos1) interferes with the formation of hydrogen bonds between GOSR2 and syntaxin-5.	Hydrogen	104-112	golgi SNAP receptor complex member 2	Homo sapiens	65-69
28982678-10	2017	In contrast, the deletion of residue p.Lys164 (or p.Arg196del in Bos1) interferes with the formation of hydrogen bonds between GOSR2 and syntaxin-5.	Hydrogen	104-112	golgi SNAP receptor complex member 2	Homo sapiens	127-132
28982678-10	2017	In contrast, the deletion of residue p.Lys164 (or p.Arg196del in Bos1) interferes with the formation of hydrogen bonds between GOSR2 and syntaxin-5.	Hydrogen	104-112	syntaxin 5	Homo sapiens	137-147
29172447-5	2017	Furthermore, the hydrogen bonds between the PEO and the CNF may behave as crystallization nuclei for the PEO.	Hydrogen	17-25	NPHS1 adhesion molecule, nephrin	Homo sapiens	56-59
29107538-5	2017	Hydrogen-deuterium exchange was used to map the Rag binding site to the outer face of the Lamtor2:Lamtor3 dimer and to the N-terminal intrinsically disordered region of Lamtor1.	Hydrogen	0-8	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	Homo sapiens	98-105
29107538-5	2017	Hydrogen-deuterium exchange was used to map the Rag binding site to the outer face of the Lamtor2:Lamtor3 dimer and to the N-terminal intrinsically disordered region of Lamtor1.	Hydrogen	0-8	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	Homo sapiens	169-176
29199977-5	2017	In the G12A K-Ras-GTP complex, the switch I region undergoes a significant reorganization such that the Tyr32 side chain points towards the GTP-binding pocket and forms a hydrogen bond to the GTP gamma-phosphate, effectively stabilizing GTP in its precatalytic state, increasing the activation energy required to reach the transition state and contributing to the reduced intrinsic GTPase activity of G12A K-Ras mutants.	Hydrogen	171-179	KRAS proto-oncogene, GTPase	Homo sapiens	12-17
29185121-1	2017	Spin-polarized first-principles total-energy calculations have been performed to investigate the possible chain reaction of acetylene molecules mediated by hydrogen abstraction on hydrogenated hexagonal boron nitride monolayers.	Hydrogen	156-164	spindlin 1	Homo sapiens	0-4
29176605-7	2017	Computational analysis depicted the influential role of CuO nanoparticles on zebrafish embryo"s he1a, sod1 and p53 functional expression through hydrophobic and hydrogen bond interaction with amino acid residues.	Hydrogen	161-169	hatching enzyme 1, tandem duplicate 1	Danio rerio	96-100
29111652-6	2017	Then, diarylethene/[bmim]NTf2 was supported on cellulose fibers within the paper, through hydrogen bonding between [bmim] cations of the ionic liquid and the abundant hydroxyl groups of cellulose.	Hydrogen	90-98	nuclear transport factor 2	Homo sapiens	25-29
29058410-7	2017	We present methodology and software for efficient interactive optimization of spin parameters against experimental 1D-1H NMR spectra of small molecules.	Hydrogen	118-120	spindlin 1	Homo sapiens	78-82
29164349-7	2017	The results of the calculations show that both derivatives with the Aib residue in the gas phase prefer structures stabilized by intramolecular N-H O hydrogen bonds, i.e., C5 and C7 conformations, while polar solvent promotes helical conformation with phi, psi values equal to +/-60 , +/-40 .	Hydrogen	150-158	ANIB1	Homo sapiens	68-71
28634060-6	2017	AMG was predicted to bind to MAO-B with an energy of -23.1kcal/mol by possible hydrogen-bond formation between an oxygen atom of Ile477 residue and a hydrogen atom (H17) of AMG.	Hydrogen	79-87	monoamine oxidase B	Homo sapiens	29-34
28634060-6	2017	AMG was predicted to bind to MAO-B with an energy of -23.1kcal/mol by possible hydrogen-bond formation between an oxygen atom of Ile477 residue and a hydrogen atom (H17) of AMG.	Hydrogen	150-158	monoamine oxidase B	Homo sapiens	29-34
29126075-0	2017	Spin diffusion and 1H spin-lattice relaxation in Cs2(HSO4)(H2PO4) containing a small amount of ammonium ions.	Hydrogen	19-21	spindlin 1	Homo sapiens	22-26
29126075-1	2017	Inorganic solid acid salts with hydrogen bond networks frequently show very long spin-lattice relaxation times even for 1H because the hydrogen bonds suppress motions.	Hydrogen	32-40	spindlin 1	Homo sapiens	81-85
29126075-1	2017	Inorganic solid acid salts with hydrogen bond networks frequently show very long spin-lattice relaxation times even for 1H because the hydrogen bonds suppress motions.	Hydrogen	120-122	spindlin 1	Homo sapiens	81-85
29126075-1	2017	Inorganic solid acid salts with hydrogen bond networks frequently show very long spin-lattice relaxation times even for 1H because the hydrogen bonds suppress motions.	Hydrogen	135-143	spindlin 1	Homo sapiens	81-85
29126075-2	2017	In the present work, the 1H spin-lattice relaxation in Cs2(HSO4)(H2PO4) containing a small amount of ammonium ions were studied in detail by use of the effect of magic angle spinning (MAS) on the relaxation.	Hydrogen	25-27	spindlin 1	Homo sapiens	28-32
29036898-0	2017	Highly Sensitive and Selective Hydrogen Gas Sensor Using the Mesoporous SnO2 Modified Layers.	Hydrogen	31-39	strawberry notch homolog 2	Homo sapiens	72-75
28501601-1	2017	Novel Tyrosinase Inhibitors of 4-functionalized Thiophene-2-carbaldehyde thiosemicarbazone (TCT) derivatives (1-8) had been synthesized and Spectrofluorimetry, 1H and 13C NMR titration and Molecular docking had been used to investigate their inhibitory activities and mechanisms on tyrosinase.	Hydrogen	160-162	tyrosinase	Homo sapiens	6-16
28501601-2	2017	The results showed that the inter-molecular interactions or hydrogen bond formation by increasing length of carbon chain or introducing benzene ring to the 4-functionalized ester group promoted or stabilized formation of complexes between modifier and tyrosinase, and enhanced the inhibitory activity of modifiers.	Hydrogen	60-68	tyrosinase	Homo sapiens	252-262
28862844-7	2017	This was further exemplified by aromaticity analysis of the heterolytic hydrogen cleavage reaction of ruthenium PNN complexes of Milstein and the PN3 of Huang, with similar geometries but distinctive thermodynamic preference.	Hydrogen	72-80	sodium voltage-gated channel alpha subunit 10	Homo sapiens	146-149
35018710-6	2022	Finally, 5 MSi (M = Rh, Pd, Pt, Ru, Ir) as highly active hydrogen-evolving electrocatalysts are identified.	Hydrogen	57-65	RB binding protein 4, chromatin remodeling factor	Homo sapiens	11-14
35410855-11	2022	Although pepsinogen and small intestinal bacterial overgrowth seem irrelevant, elevated gastrin level may cautiously indicate a decreased breath hydrogen concentration.	Hydrogen	145-153	gastrin	Homo sapiens	88-95
28796507-8	2017	Moreover, intermolecular beta-sheets also are generated between P1 and P2 through hydrogen bonding interactions.	Hydrogen	82-90	crystallin gamma F, pseudogene	Homo sapiens	64-73
35347964-13	2022	Molecular docking showed that PPA bound to the ETS domain of ETS-1, the transcription factor of CIP2 A, and formed hydrogen bonds with Pro319 and Asp317.	Hydrogen	115-123	ETS proto-oncogene 1, transcription factor	Homo sapiens	61-66
28781083-0	2017	KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry.	Hydrogen	89-97	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
35084169-11	2022	Meanwhile, the sensing mechanism in gas adsorption was also discussed in terms of LSER formulation and hydrogen bonding formation between SXFA and DMMP.	Hydrogen	103-111	gastrin	Homo sapiens	36-39
28872061-6	2017	The preferred syn conformation of these 1-arylurazole dimers results in the two aromatic rings being proximate and nearly parallel, which leads to some interesting shielding effects of certain signals in the 1H NMR spectrum.	Hydrogen	208-210	synemin	Homo sapiens	14-17
35269699-2	2022	In this work, we explored (E)-4-amino-3-((3,5-di-tert-butyl-2-hydroxybenzylidene)amino) benzoic acid (SB-1, harboring an intramolecular hydrogen bond) and (E)-2-((4-nitrobenzilidene)amino)aniline (SB-2), two Schiff bases derivatives.	Hydrogen	136-144	SH3KBP1 binding protein 1	Homo sapiens	102-106
28344141-9	2017	CONCLUSION: Strategies using a single hs-cTnI alone or in combination with a normal ECG allow the immediate identification of patients unlikely to have acute myocardial infarction and who are at very low risk for adverse events at 30 days.	Hydrogen	38-40	troponin I3, cardiac type	Homo sapiens	41-45
28633380-6	2017	They also prevented the appearance of ordered side-chain hydrogen bonding in ATX3-Q55, which is the hallmark of polyQ-related amyloids.	Hydrogen	57-65	Ataxin-3 homolog	Caenorhabditis elegans	77-81
35269699-5	2022	Furthermore, we provide a comprehensive physicochemical and theoretical characterization of SB-1 (as well as several analyses for SB-2), including elemental analysis, ESMS, 1H and 13C NMR (assigned by 1D and 2D techniques), DEPT, UV-Vis, FTIR, and cyclic voltammetry.	Hydrogen	173-175	SH3KBP1 binding protein 1	Homo sapiens	92-96
35143180-7	2022	The highest value of 1071 min-1 can be achieved for CMNR immobilized with Cu-Ag2 owing to the suitable adsorption activation behavior and the best hydrogen spillover behavior.	Hydrogen	147-155	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	77-80
29291213-8	2017	The results revealed that the common pharmacophore hypothesis ADHPR.1 was used for 3D-QSAR model development and the most active compound, CXCR4 antagonist no.44 which is a imidazopyridine-tetrahydro-8-quinolinamine derivative interacted with the CXCR4 receptor residue ASP 97 by the formation of a hydrogen bond.	Hydrogen	299-307	C-X-C motif chemokine receptor 4	Homo sapiens	139-144
29291213-8	2017	The results revealed that the common pharmacophore hypothesis ADHPR.1 was used for 3D-QSAR model development and the most active compound, CXCR4 antagonist no.44 which is a imidazopyridine-tetrahydro-8-quinolinamine derivative interacted with the CXCR4 receptor residue ASP 97 by the formation of a hydrogen bond.	Hydrogen	299-307	C-X-C motif chemokine receptor 4	Homo sapiens	247-252
35168606-11	2022	Decreased expressions of GPCPD1 and GDE1 in choline metabolism led to an increased GPC levels in the PTX-resistant EOCs, which was observed as an elevated total choline (tCho) on in vivo 1H-MRS.	Hydrogen	187-189	glycerophosphocholine phosphodiesterase 1	Homo sapiens	25-31
35084406-5	2022	All these properties make the CSHS a direct Z-scheme system with the hydrogen and oxygen evolution reactions occurring, respectively, at the CdS and SnS2 layers.	Hydrogen	69-77	CDP-diacylglycerol synthase 1	Homo sapiens	141-144
28505536-10	2017	Molecular docking attributed their good VEGFR-2 inhibitory activity to their hydrogen bonding interaction with the key amino acids in VEGFR-2 active site, Glu885 and Asp1046, and their hydrophobic interaction by their 2-furylbenzimidazole moiety with the allosteric hydrophobic back pocket in a type III inhibitors-like binding mode.	Hydrogen	77-85	kinase insert domain receptor	Homo sapiens	40-47
28505536-10	2017	Molecular docking attributed their good VEGFR-2 inhibitory activity to their hydrogen bonding interaction with the key amino acids in VEGFR-2 active site, Glu885 and Asp1046, and their hydrophobic interaction by their 2-furylbenzimidazole moiety with the allosteric hydrophobic back pocket in a type III inhibitors-like binding mode.	Hydrogen	77-85	kinase insert domain receptor	Homo sapiens	134-141
35113495-8	2022	Substitutions corresponding to N80 and Y139 in human VKOR provide strong hydrogen bonding interactions to facilitate the epoxide reduction.	Hydrogen	73-81	vitamin K epoxide reductase complex subunit 1	Homo sapiens	53-57
28701464-12	2017	We conclude that the most likely catalytic mechanism begins with abstraction of a hydrogen atom from C-4 (or possibly C-3) initiating the desaturation pathway, followed by a sequential abstraction of a hydrogen atom or proton-coupled electron transfer.	Hydrogen	82-90	complement C3	Homo sapiens	118-121
28701464-12	2017	We conclude that the most likely catalytic mechanism begins with abstraction of a hydrogen atom from C-4 (or possibly C-3) initiating the desaturation pathway, followed by a sequential abstraction of a hydrogen atom or proton-coupled electron transfer.	Hydrogen	202-210	complement C3	Homo sapiens	118-121
34989743-6	2022	The analysis of fluorescence spectra demonstrated that the formation of the trilobatin-alpha-glucosidase complex was driven mainly by hydrogen bonding and van der Waals forces, resulting in the conformational changes of alpha-glucosidase.	Hydrogen	134-142	sucrase-isomaltase	Homo sapiens	87-104
29086859-5	2017	The molecular docking results displayed that the ligand-protein binding affinity to VEGFR-2 could be enhanced by introducing a hydrogen-bond-donating (HBD) substituent at C(5) of (2-oxoindolin-3-ylidene)methylpyrrole such as 14 (C(5)-OH) and 15 (C(5)-SH).	Hydrogen	127-135	kinase insert domain receptor	Homo sapiens	84-91
34876699-3	2021	Here, we apply hydrogen-deuterium exchange mass spectrometry (HDX-MS) to describe the dynamics of the full-length Hsp70 in the cytosol and its conformational changes upon translocation into lysosomes.	Hydrogen	15-23	heat shock protein family A (Hsp70) member 4	Homo sapiens	114-119
34874953-0	2021	1H, 13C and 15N resonance assignment of the SARS-CoV-2 full-length nsp1 protein and its mutants reveals its unique secondary structure features in solution.	Hydrogen	0-2	SH2 domain containing 3A	Homo sapiens	67-71
34989743-6	2022	The analysis of fluorescence spectra demonstrated that the formation of the trilobatin-alpha-glucosidase complex was driven mainly by hydrogen bonding and van der Waals forces, resulting in the conformational changes of alpha-glucosidase.	Hydrogen	134-142	sucrase-isomaltase	Homo sapiens	220-237
35056725-1	2022	In the context of our SAR study concerning 6BrCaQ analogues as C-terminal Hsp90 inhibitors, we designed and synthesized a novel series of 3-(heteroaryl)quinolin-2(1H), of types 3, 4, and 5, as a novel class of analogues.	Hydrogen	163-165	heat shock protein 90 alpha family class A member 1	Homo sapiens	74-79
34943036-3	2021	The purpose of this study was to investigate the effect of hydrogen gas (3%) on early chronic liver injury (CLI) induced by CCl4 and to preliminarily explore the protective mechanism of hydrogen gas on hepatocytes by observing the expression of uncoupling protein 2 (UCP2) in liver tissue.	Hydrogen	186-194	uncoupling protein 2	Rattus norvegicus	245-265
34943036-3	2021	The purpose of this study was to investigate the effect of hydrogen gas (3%) on early chronic liver injury (CLI) induced by CCl4 and to preliminarily explore the protective mechanism of hydrogen gas on hepatocytes by observing the expression of uncoupling protein 2 (UCP2) in liver tissue.	Hydrogen	186-194	uncoupling protein 2	Rattus norvegicus	267-271
34943036-8	2021	When the hydrogen gas was inhaled, hepatocyte steatosis was reduced, and the UCP2 expression level in liver tissue was increased.	Hydrogen	9-17	uncoupling protein 2	Rattus norvegicus	77-81
34943036-9	2021	These results suggest that hydrogen gas might upregulate UCP2 expression levels, reduce the generation of intracellular oxygen free radicals, affect lipid metabolism in liver cells, and play a protective role in liver cells.	Hydrogen	27-35	uncoupling protein 2	Rattus norvegicus	57-61
27853987-4	2017	Interactions between TSPO binding pocket and novel ligands were evaluated and compared with contemporary TSPO ligands using 2D 1H-15N heteronuclear single quantum coherence (HSQC) spectroscopy.	Hydrogen	127-129	translocator protein	Rattus norvegicus	21-25
35071188-4	2021	Using this approach, we perform a pioneering analysis of the impact of the spatial confinement caused by a cylindrical harmonic oscillator potential on the harmonic vibrational transition intensities and frequencies of two hydrogen-bonded complexes: HCN...HCN and HCN...HNC.	Hydrogen	223-231	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	250-253
28612409-7	2017	The analysis of H2 -TPR curves concludes that there exists hydrogen spillover related to the strong metal-support interaction between Pd species and oxides.	Hydrogen	59-67	translocated promoter region, nuclear basket protein	Homo sapiens	20-23
28613440-2	2017	H3 O+ forms hydrogen bonds (H-bonds) with two histidine side-chains and a backbone carbonyl group in PcyA, whereas H3 O+ forms H-bonds with three acidic residues in XI.	Hydrogen	12-20	H3 clustered histone 15	Homo sapiens	0-4
34560931-2	2021	The physicochemical characteristics of starch and St-g-PDMC-LPUV were characterized by FT-IR, 1H NMR, XRD, TGA, SEM and BET to confirmed the successful grafting DMC onto starch.	Hydrogen	94-96	chromosome 6 open reading frame 15	Homo sapiens	50-54
35071188-4	2021	Using this approach, we perform a pioneering analysis of the impact of the spatial confinement caused by a cylindrical harmonic oscillator potential on the harmonic vibrational transition intensities and frequencies of two hydrogen-bonded complexes: HCN...HCN and HCN...HNC.	Hydrogen	223-231	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	256-259
34214725-2	2021	Here, we have demonstrated that the modulation of the Schottky barrier height between the interface of metal (Pd/Au) and multilayered ReSe2 nanoflakes caused the change in the transfer curve (Ids-Vbg) of FETs based devices and rectifying characteristics (Ids-Vds) of the Schottky diodes at various hydrogen concentrations at T = 22  C, fluctuating from 50 to 350 ppm with a response (R%) from 669 to 1198%, respectively.	Hydrogen	298-306	iduronate 2-sulfatase	Homo sapiens	192-195
35071188-4	2021	Using this approach, we perform a pioneering analysis of the impact of the spatial confinement caused by a cylindrical harmonic oscillator potential on the harmonic vibrational transition intensities and frequencies of two hydrogen-bonded complexes: HCN...HCN and HCN...HNC.	Hydrogen	223-231	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	264-267
34214725-2	2021	Here, we have demonstrated that the modulation of the Schottky barrier height between the interface of metal (Pd/Au) and multilayered ReSe2 nanoflakes caused the change in the transfer curve (Ids-Vbg) of FETs based devices and rectifying characteristics (Ids-Vds) of the Schottky diodes at various hydrogen concentrations at T = 22  C, fluctuating from 50 to 350 ppm with a response (R%) from 669 to 1198%, respectively.	Hydrogen	298-306	iduronate 2-sulfatase	Homo sapiens	255-258
28686246-2	2017	The formation of a DMY-tyrosinase complex led to fluorescence quenching and conformational changes of tyrosinase, which was driven mainly by hydrophobic interactions and hydrogen bonds.	Hydrogen	170-178	tyrosinase	Homo sapiens	23-33
35572410-6	2022	In addition, sulfur dioxide (SO2), methane (CH4), hydrogen gas (H2), ammonia (NH3), and carbon dioxide (CO2) can also be generated endogenously and may take part in physiological and pathological processes.	Hydrogen	50-58	gastrin	Homo sapiens	59-62
28686246-2	2017	The formation of a DMY-tyrosinase complex led to fluorescence quenching and conformational changes of tyrosinase, which was driven mainly by hydrophobic interactions and hydrogen bonds.	Hydrogen	170-178	tyrosinase	Homo sapiens	102-112
34848745-10	2021	Key arginine residues at positions 57, 58 and 68 of GRIM-19 are mainly involved in the hydrogen-bonded interactions.	Hydrogen	87-95	NADH:ubiquinone oxidoreductase subunit A13	Homo sapiens	52-59
28457444-5	2017	XRD and DSC investigated that there was strong interaction caused by hydrogen bonding between molecular chain of MCS and MPVA.	Hydrogen	69-77	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	113-116
2598942-2	1989	The solution conformation of the 27-residue polypeptide hormone secretin in dimethyl sulfoxide has been determined on the basis of 1H-NMR measurements.	Hydrogen	131-133	secretin	Homo sapiens	64-72
28652325-5	2017	Molecular modeling indicates that CD16A TM residues F202, D205, and T206 form the core of the membrane-embedded trimeric interface by establishing highly favorable contacts to the signaling modules through rearrangement of a hydrogen bond network previously identified in the CD247 TM dimer solution NMR structure.	Hydrogen	225-233	Fc gamma receptor IIIa	Homo sapiens	34-38
28731753-0	2017	New Measurements of the Beam Normal Spin Asymmetries at Large Backward Angles with Hydrogen and Deuterium Targets.	Hydrogen	83-91	spindlin 1	Homo sapiens	36-40
28640992-4	2017	Upon simple thermal annealing, the t-Boc groups were removed and the soluble pigment precursor molecules with latent hydrogen bonding were converted into the original pigment molecules with fused hydrogen bonding.	Hydrogen	117-125	BOC cell adhesion associated, oncogene regulated	Homo sapiens	37-40
28640992-4	2017	Upon simple thermal annealing, the t-Boc groups were removed and the soluble pigment precursor molecules with latent hydrogen bonding were converted into the original pigment molecules with fused hydrogen bonding.	Hydrogen	196-204	BOC cell adhesion associated, oncogene regulated	Homo sapiens	37-40
28563699-2	2017	A previous study on the neutron crystal structure of TTR suggested that a large hydrogen bond network around H88 which includes water molecules is significantly involved in the stability of wild-type TTR (WT-TTR).	Hydrogen	80-88	transthyretin	Homo sapiens	53-56
28563699-2	2017	A previous study on the neutron crystal structure of TTR suggested that a large hydrogen bond network around H88 which includes water molecules is significantly involved in the stability of wild-type TTR (WT-TTR).	Hydrogen	80-88	transthyretin	Homo sapiens	200-203
28563699-2	2017	A previous study on the neutron crystal structure of TTR suggested that a large hydrogen bond network around H88 which includes water molecules is significantly involved in the stability of wild-type TTR (WT-TTR).	Hydrogen	80-88	transthyretin	Homo sapiens	200-203
28563699-4	2017	In order to clarify the role of H88 and the hydrogen bond network in the stability of TTR, we determined the thermodynamic stability and the crystal structure of H88 mutants (H88A, H88F, H88Y, and H88S).	Hydrogen	44-52	transthyretin	Homo sapiens	86-89
28590005-2	2017	The synthesized compounds, Li2B12H12 7NH3, Na2B12H12 4NH3 and CaB12H12 6NH3, contain high amounts of NH3, 43.3, 26.6 and 35.9 wt% NH3, respectively, which can be released and absorbed reversibly at moderate conditions without decomposition, thereby making the closo-boranes favorable "host" materials for ammonia or indirect hydrogen storage in the solid state.	Hydrogen	325-333	neural proliferation, differentiation and control 1	Homo sapiens	62-65
28515263-8	2017	Taken together, using the complementary experimental approaches of chemical modification of the ligand and site-directed mutagenesis of TRPM2, we demonstrate that channel activation critically depends on hydrogen bonding of Arg1433 and Tyr1349 with the terminal ribose.	Hydrogen	204-212	transient receptor potential cation channel subfamily M member 2	Homo sapiens	136-141
30108874-4	2017	In particular, the 3,4-dichlorobenzyl derivative 5b showed a comparable or superior activity against all the tested fungal strains to standard drugs, and formed a supramolecular complex with CYP51 via the hydrogen bond between the 4-nitrogen of the triazole nucleus and the histidine residue.	Hydrogen	205-213	lanosterol 14-alpha demethylase	Bos taurus	191-196
28453785-9	2017	Hydrogen-deuterium exchange indicates protection of a surface on the PNKP phosphatase domain that may contact XRCC4-LigIV.	Hydrogen	0-8	polynucleotide kinase 3'-phosphatase	Homo sapiens	69-73
28596808-5	2017	It has been suggested that saturated hydrogen saline may downregulate expression of nuclear factor (NF)-kappaB, leading to a decrease in Beclin-1 transcription and inhibition of autophagy.	Hydrogen	37-45	beclin 1	Homo sapiens	137-145
28571327-5	2017	The use of the nuclear spin-nuclear spin interaction terms Daa, Dbb, and Dcc for H2 were required to fit the ortho state of hydrogen, as well as a nuclear-spin rotation constant Caa.	Hydrogen	81-83	DCC netrin 1 receptor	Homo sapiens	73-76
28571327-5	2017	The use of the nuclear spin-nuclear spin interaction terms Daa, Dbb, and Dcc for H2 were required to fit the ortho state of hydrogen, as well as a nuclear-spin rotation constant Caa.	Hydrogen	124-132	DCC netrin 1 receptor	Homo sapiens	73-76
28538145-9	2017	At2g44920 exhibited a striking range of amide hydrogen exchange rates spanning 10 orders of magnitude, with lifetimes ranging from minutes to several months.	Hydrogen	46-54	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	0-9
28377057-5	2017	The EP4-receptor-expressing LNCaP prostate cancer xenografts were clearly visualized in PET images with 1.12+-0.08%ID/g (n=5) uptake value and moderate tumour-to-muscle contrast ratio (2.73+-0.22) at 1h post-injection.	Hydrogen	200-202	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	4-7
27359323-9	2017	The results showed the significant contribution of hydrogen bonds and hydrophobic interaction on the UGT2B7 inhibition by vitamin A.	Hydrogen	51-59	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	101-107
28368045-2	2017	The as-prepared CNF/GO aerogel possesses interconnected 3D network microstructure, in which GO nanosheets with 2D structure were intimately grown along CNF through hydrogen bonds.	Hydrogen	164-172	NPHS1 adhesion molecule, nephrin	Homo sapiens	16-19
28368045-2	2017	The as-prepared CNF/GO aerogel possesses interconnected 3D network microstructure, in which GO nanosheets with 2D structure were intimately grown along CNF through hydrogen bonds.	Hydrogen	164-172	NPHS1 adhesion molecule, nephrin	Homo sapiens	152-155
28322397-9	2017	The excess gravimetric and volumetric H2 uptakes at 77 K and 2.0 MPa hit a maximum of 14.12 wt% and 603.35 cm3 (STP) cm-3, respectively, which substantially exceeds those previously reported for MOF or PAF materials.	Hydrogen	38-40	thyroid hormone receptor interactor 10	Homo sapiens	112-115
27780757-0	2017	Heterologous expression of the human Phosphoenol Pyruvate Carboxykinase (hPEPCK-M) improves hydrogen and ethanol synthesis in the Escherichia coli dcuD mutant when grown in a glycerol-based medium.	Hydrogen	92-100	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	73-81
28198627-2	2017	The inelastic contribution to the STM current is found to excite a large number of skeletal vibrational modes of the molecule, thereby inducing a deformation of the potential energy landscape along the hydrogen transfer coordinate.	Hydrogen	202-210	sulfotransferase family 1A member 3	Homo sapiens	34-37
28183024-1	2017	SABRE (Signal Amplification By Reversible Exchange) is a nuclear spin hyperpolarization technique based on the reversible concurrent binding of small molecules and para-hydrogen (p-H2) to an iridium metal complex in solution.	Hydrogen	169-177	polyhomeotic homolog 2	Homo sapiens	179-183
27864003-2	2017	Arg274 located in the ligand binding domain (LBD) of VDR is responsible for anchoring 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3) by forming a hydrogen bond with the 1alpha-hydroxyl group of 1alpha,25(OH)2D3.	Hydrogen	148-156	vitamin D receptor	Homo sapiens	53-56
27986851-6	2017	Using hydrogen-deuterium eXchange coupled to mass spectrometry, we obtained experimental evidences that the Trm11-Trm112 interaction relies on the same molecular bases as those described for other Trm112-methyltransferases complexes.	Hydrogen	6-14	tRNA methyltransferase activator subunit 11-2	Homo sapiens	114-120
27986851-6	2017	Using hydrogen-deuterium eXchange coupled to mass spectrometry, we obtained experimental evidences that the Trm11-Trm112 interaction relies on the same molecular bases as those described for other Trm112-methyltransferases complexes.	Hydrogen	6-14	tRNA methyltransferase activator subunit 11-2	Homo sapiens	197-203
28106222-7	2017	It showed that GA would non-covalently interact with starch molecules and contribute to ordered structure formation to somewhat extent; meanwhile, GA had higher binding affinities to alpha-amylase than to starch chains; during the hydrolytic process, GA could be released from the complex and was more likely to occupy the active sites of Asp197, Asp300, His299 and Glu233 by hydrogen bonds and van der Waals forces, which kept starch out of the active site pocket and reduced starch digestibility.	Hydrogen	376-384	alpha-amylase	Zea mays	183-196
28082425-7	2017	Allosteric propagation proceeds from Nedd8 via Cul5 dynamic hinges and hydrogen bonds between the C-terminal domain of Cul5 (Cul5CTD) and Rbx1 (Cul5CTD residues R538/R569 and Rbx1 residue E67, or Cul5CTD E474/E478/N491 and Rbx1 K105).	Hydrogen	71-79	ring-box 1	Homo sapiens	138-142
28087437-9	2017	Furthermore, the protective effects of hydrogen-rich saline were accompanied by the increased activity of glucose-regulated protein 78 (GRP78), the decreased activity of cysteinyl aspartate specific proteinase-12 (caspase-12) and C/EBP homologous protein (CHOP).	Hydrogen	39-47	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	106-134
28087437-9	2017	Furthermore, the protective effects of hydrogen-rich saline were accompanied by the increased activity of glucose-regulated protein 78 (GRP78), the decreased activity of cysteinyl aspartate specific proteinase-12 (caspase-12) and C/EBP homologous protein (CHOP).	Hydrogen	39-47	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	136-141
27412293-4	2017	We here report that structural instability of the activated VDR becomes apparent when observing hydrogen bond behavior with molecular dynamics, revealing that the VDR pathway exhibits a susceptibility to Electrosmog.	Hydrogen	96-104	vitamin D receptor	Homo sapiens	60-63
27412293-4	2017	We here report that structural instability of the activated VDR becomes apparent when observing hydrogen bond behavior with molecular dynamics, revealing that the VDR pathway exhibits a susceptibility to Electrosmog.	Hydrogen	96-104	vitamin D receptor	Homo sapiens	163-166
28012298-3	2017	This amounts to converting the spin-state selectivity from 1H spin states to 13C spin states in the spectra of long-range coupled 1H spins, allowing convenient measurement of heteronuclear coupling constants similar to other S3 or E.COSY-type methods.	Hydrogen	59-61	spindlin 1	Homo sapiens	31-35
28012298-3	2017	This amounts to converting the spin-state selectivity from 1H spin states to 13C spin states in the spectra of long-range coupled 1H spins, allowing convenient measurement of heteronuclear coupling constants similar to other S3 or E.COSY-type methods.	Hydrogen	59-61	spindlin 1	Homo sapiens	62-66
28012298-3	2017	This amounts to converting the spin-state selectivity from 1H spin states to 13C spin states in the spectra of long-range coupled 1H spins, allowing convenient measurement of heteronuclear coupling constants similar to other S3 or E.COSY-type methods.	Hydrogen	59-61	spindlin 1	Homo sapiens	62-66
27342272-9	2017	RESULTS: The results showed that both profiles of high-dose H2 breathing reduced the size of the endometrial explants, inhibited cell proliferation, improved superoxide dismutase, glutathione peroxidase, malondialdehyde, and catalase activities, and regulated the expression of matrix metalloproteinase 9 and cyclooxygenase 2.	Hydrogen	60-62	matrix metallopeptidase 9	Rattus norvegicus	278-304
28005057-6	2017	In particular, the CPT (charge conjugation, parity reversal and time reversal) theorem, a cornerstone of the Standard Model, requires that hydrogen and antihydrogen have the same spectrum.	Hydrogen	139-147	choline phosphotransferase 1	Homo sapiens	19-22
28067378-0	2017	Hot electron-driven hydrogen evolution using anisotropic gold nanostructure assembled monolayer MoS2.	Hydrogen	20-28	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
27966811-1	2017	Visible-light irradiation of a ternary hybrid catalyst prepared by grafting a dye, an H2 evolving CoIII catalyst and a CO-producing ReI catalyst on TiO2 have been found to produce both H2 and CO (syngas) in CO2 -saturated N,N-dimethyl formamide (DMF)/water solution containing a 0.1 m sacrificial electron donor.	Hydrogen	86-88	relaxin 2	Homo sapiens	185-194
27762555-1	2017	A new Leu-enkephalin peptidomimetic designed to explore the hydrogen bond acceptor ability of the third peptide bond has been prepared and studied.	Hydrogen	60-68	prodynorphin	Mus musculus	6-20
27762555-7	2017	Together with our previous observations, our findings strongly suggest that the third amide bond of Leu-enkephalin primarily acts as a hydrogen bond acceptor in DOPr.	Hydrogen	135-143	prodynorphin	Mus musculus	100-114
28061508-2	2017	Upon ligand binding, the LBP reshapes around the contours of the ligand and stabilizes the complex by complementary hydrophobic interactions and specific hydrogen bonds with the ligand.	Hydrogen	154-162	lipopolysaccharide binding protein	Homo sapiens	25-28
28798900-5	2017	In this focus review, we summarize recent efforts towards identification of the active sites in MoS x -based electrocatalysts for the hydrogen evolution reaction (HER).	Hydrogen	134-142	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	96-99
28035984-7	2016	The docking simulation results demonstrated that four residues of PTP1B (Gly183, Arg221, Ile219, Gly220) interact with three hydroxyl groups of alaternin and that the binding energy was negative (-6.30 kcal/mol), indicating that the four hydrogen bonds stabilize the open form of the enzyme and potentiate tight binding of the active site of PTP1B, resulting in more effective PTP1B inhibition.	Hydrogen	238-246	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	66-71
27748579-7	2016	In APT1, the trifluoromethyl group of ML348 is positioned above the catalytic triad, but in APT2, the sulfonyl group of ML349 forms hydrogen bonds with active site resident waters to indirectly engage the catalytic triad and oxyanion hole.	Hydrogen	132-140	lysophospholipase 2	Homo sapiens	92-96
27596008-9	2016	Hydrogen gas inhalation markedly improved lung endothelial permeability and decreased both MDA content and MPO activity in lung tissue; these changes were associated with decreases in TNF-alpha, IL-1beta, and IL-6 in BALF.	Hydrogen	0-8	myeloperoxidase	Oryctolagus cuniculus	107-110
27655633-7	2016	We employed hydrogen/deuterium exchange combined with mass spectrometry to identify three peptides, all residing within the OB-fold of TPP1, that exhibit altered exchange rates upon complex formation or ssDNA binding.	Hydrogen	12-20	tripeptidyl peptidase 1	Homo sapiens	135-139
27729469-6	2016	By mixing 13C-enriched maize CWs with EXPB1 functionalized with a Mn2+ tag, we measured Mn2+-induced PRE Strong 1H and 13C PREs were observed for the carboxyls of GAX, followed by more moderate PREs for carboxyl groups in homogalacturonan and rhamnogalacturonan-I, indicating that EXPB1 preferentially binds GAX In contrast, no PRE was observed for cellulose, indicating very weak interaction of EXPB1 with cellulose.	Hydrogen	112-114	expansin-B1	Zea mays	38-43
28039406-11	2016	Across groups, granulocyte CD11b expression was upregulated from PRE to IP (P &lt; 0.001) and 1H (P = 0.015).	Hydrogen	94-96	integrin subunit alpha M	Homo sapiens	27-32
27699881-6	2016	Structural comparison of reversine bound to Mps1 and Aurora B, indicates a similar binding pose for the purine moiety of reversine making three conserved hydrogen bonds to the protein main chain, explaining the observed promiscuity of this inhibitor.	Hydrogen	154-162	aurora kinase B	Homo sapiens	53-61
27879664-8	2016	Furthermore, CTB suppressed the phosphorylation of MKK3/6 by targeting the binding sites via formation of hydrogen bonds.	Hydrogen	106-114	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	13-16
27806276-6	2016	Hydrogen-deuterium-exchange mass spectrometry demonstrates that the H223Q replacement results in a loss of stability of the amphipathic helices TH1-3 and the hydrophobic core helix TH8 at pH 6.5.	Hydrogen	0-8	negative elongation factor complex member C/D	Homo sapiens	144-149
27722387-5	2016	Upon addition of calcium ions to an alkaline Tar2- solution, the 1H NMR signal gradually broadened and the 13C-satellite peaks split to two components, which also indicate complexation.	Hydrogen	65-67	trace amine associated receptor 2	Homo sapiens	45-49
27649550-0	2016	Molecular design and validation of halogen bonding orthogonal to hydrogen bonding in breast cancer MDM2-peptide complex.	Hydrogen	65-73	MDM2 proto-oncogene	Homo sapiens	99-103
27649550-2	2016	Here, we performed molecular design of halogen bonding orthogonal to hydrogen bonding at the complex interface of MDM2 protein with its cognate peptide ligand to improve the peptide binding affinity and specificity.	Hydrogen	69-77	MDM2 proto-oncogene	Homo sapiens	114-118
27329301-10	2016	Hydrogen bond acceptor, 2D autocorrelations, GETAWAY descriptors, and BCUT descriptors were identified as key structural features for selectivity and activity of ACAT-2 inhibitors.	Hydrogen	0-8	acetyl-CoA acetyltransferase 2	Homo sapiens	162-168
27792778-1	2016	We study the dynamic propensity of the backbone hydrogen bonds of the protein MDM2 (the natural regulator of the tumor suppressor p53) in order to determine its binding properties.	Hydrogen	48-56	MDM2 proto-oncogene	Homo sapiens	78-82
27792778-3	2016	To this end, we conduct a series of hydrogen bond propensity calculations in different contexts: 1) computational alanine-scanning studies of the MDM2-p53 interface; 2) the formation of the complex of MDM2 with the disruptive small molecule Nutlin-3a (dissecting the contribution of the different molecular fragments) and 3) the binding of a series of small molecules (drugs) with different affinities for MDM2.	Hydrogen	36-44	MDM2 proto-oncogene	Homo sapiens	201-205
27783615-12	2016	This theoretical investigation shows that thermodynamic control of PH2 on individual VFA produced and associated yield of hydrogen and methane cannot be explained without considering NADH oxidation.	Hydrogen	122-130	polyhomeotic homolog 2	Homo sapiens	67-70
27717045-7	2016	This is interpreted in terms of suppression of the ability of the cavitand to form hydrogen bonds at the rim of the molecule due to replacement of the C2-H proton by a methyl group, while the hydrophobic pocket of the molecule maintains its binding abilities.	Hydrogen	83-91	regulating synaptic membrane exocytosis 1	Homo sapiens	105-108
27684431-11	2016	The thermodynamic dominance of syn conformations results from the formation of an intramolecular O5"-H13   O2 hydrogen bond.	Hydrogen	110-118	synemin	Homo sapiens	31-34
27448502-6	2016	The molecular docking studies predicted that STA could tight bind to PKCtheta via five hydrogen.	Hydrogen	87-95	protein kinase C, theta	Mus musculus	69-77
27154288-8	2016	In contrast, the expression ratio of RANKL/OPG was reduced at 1h and significantly increased at 12h.	Hydrogen	62-64	TNF superfamily member 11	Homo sapiens	37-42
27154288-8	2016	In contrast, the expression ratio of RANKL/OPG was reduced at 1h and significantly increased at 12h.	Hydrogen	62-64	basic transcription factor 3 pseudogene 11	Homo sapiens	43-46
27154288-10	2016	Importantly, the canonical Wnt pathway inhibitor DKK1 blocked the osteogenesis effect and rescued the ratio of RANKL/OPG in PDLSCs under force treatment for 1h.	Hydrogen	157-159	TNF superfamily member 11	Homo sapiens	111-116
27575476-8	2016	Furthermore, Cys172 of MAO-B was found to be a key residue for hydrogen bonding with compound 4.	Hydrogen	63-71	monoamine oxidase B	Homo sapiens	23-28
27287117-7	2016	The FT-IR, XRD and TGA analysis showed that hydrogen bonds between the PAM chains and BC nanofiber clusters mainly contributed to the superior mechanical properties of hybrid hydrogels.	Hydrogen	44-52	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	71-74
27462076-7	2016	The simulations indicated hydrogen bonding is a key component leading to propofol-selective binding within GABAA receptor subunit interfaces, with stable hydrogen bonds observed between propofol and alpha/beta cavity residues but not gamma cavity residues.	Hydrogen	26-34	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	107-112
27658199-8	2016	A virtual screening approach using a model of the catalytic site of DNMT and EZH2 demonstrated that plant flavones are tethered at both ends inside the catalytic pocket of DNMT and EZH2 by means of hydrogen bonding.	Hydrogen	198-206	DNA methyltransferase 1	Bos taurus	68-72
27658199-8	2016	A virtual screening approach using a model of the catalytic site of DNMT and EZH2 demonstrated that plant flavones are tethered at both ends inside the catalytic pocket of DNMT and EZH2 by means of hydrogen bonding.	Hydrogen	198-206	enhancer of zeste 2 polycomb repressive complex 2 subunit	Bos taurus	77-81
27658199-8	2016	A virtual screening approach using a model of the catalytic site of DNMT and EZH2 demonstrated that plant flavones are tethered at both ends inside the catalytic pocket of DNMT and EZH2 by means of hydrogen bonding.	Hydrogen	198-206	DNA methyltransferase 1	Bos taurus	172-176
27658199-8	2016	A virtual screening approach using a model of the catalytic site of DNMT and EZH2 demonstrated that plant flavones are tethered at both ends inside the catalytic pocket of DNMT and EZH2 by means of hydrogen bonding.	Hydrogen	198-206	enhancer of zeste 2 polycomb repressive complex 2 subunit	Bos taurus	181-185
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Hydrogen	354-362	phosphorylase kinase catalytic subunit gamma 2	Homo sapiens	86-109
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Hydrogen	354-362	phosphorylase kinase catalytic subunit gamma 2	Homo sapiens	111-116
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Hydrogen	354-362	pumilio RNA binding family member 3	Homo sapiens	260-264
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Hydrogen	354-362	pumilio RNA binding family member 3	Homo sapiens	327-331
27351794-6	2016	In CaS ALD with 1 and H2 S, the ALD window was approximately two times wider and lower in temperature by about 150  C than previously reported with [Ca3 (tmhd)6 ] and H2 S. Complexes 1 and 2, with their excellent volatility and thermal stability (up to at least 350  C), are the first homoleptic Ca(II) amidinates suitable for use as ALD precursors.	Hydrogen	22-24	carbonic anhydrase 2	Homo sapiens	296-302
27482717-0	2016	Spin-Blocking Effect in CO and H2 Binding Reactions to Molybdenocene and Tungstenocene: A Theoretical Study on the Reaction Mechanism via the Minimum Energy Intersystem Crossing Point.	Hydrogen	31-33	spindlin 1	Homo sapiens	0-4
27482717-2	2016	Experimentally observed slow H2 binding was reasonably explained in terms of the spin-blocking effect.	Hydrogen	29-31	spindlin 1	Homo sapiens	81-85
27030885-6	2016	In this Tutorial Review, we describe our efforts of late in developing the fundamental principles and practical applications of a new copper-free click reaction - namely, cooperative capture synthesis, whereby introducing a cyclodextrin (CD) as an accelerator in CB-AAC, hydrogen bonding networks are formed between the rims of CD and CB6 in a manner that is positively cooperative, giving rise to a high level of pre-organisation during efficient and quick rotaxane formation.	Hydrogen	271-279	glycine-N-acyltransferase	Homo sapiens	266-269
27336283-3	2016	Characteristic NMR spin-spin coupling constants across hydrogen bonds of ion pair structures viz., Fermi contact, spin-orbit and spin-dipole terms show strong dependence on mutual orientation of cation with the amino acid anion.	Hydrogen	55-63	spindlin 1	Homo sapiens	19-23
27336283-3	2016	Characteristic NMR spin-spin coupling constants across hydrogen bonds of ion pair structures viz., Fermi contact, spin-orbit and spin-dipole terms show strong dependence on mutual orientation of cation with the amino acid anion.	Hydrogen	55-63	spindlin 1	Homo sapiens	24-28
27336283-3	2016	Characteristic NMR spin-spin coupling constants across hydrogen bonds of ion pair structures viz., Fermi contact, spin-orbit and spin-dipole terms show strong dependence on mutual orientation of cation with the amino acid anion.	Hydrogen	55-63	spindlin 1	Homo sapiens	24-28
27336283-3	2016	Characteristic NMR spin-spin coupling constants across hydrogen bonds of ion pair structures viz., Fermi contact, spin-orbit and spin-dipole terms show strong dependence on mutual orientation of cation with the amino acid anion.	Hydrogen	55-63	spindlin 1	Homo sapiens	24-28
27336283-4	2016	The spin-spin coupling mechanism transmits spin polarization via electric field effect originating from lp---pi interactions whereas the electron delocalization from lone pair on the carbonyl oxygen to antibonding C-H orbital is facilitated by hydrogen bonding.	Hydrogen	244-252	spindlin 1	Homo sapiens	4-8
27336283-4	2016	The spin-spin coupling mechanism transmits spin polarization via electric field effect originating from lp---pi interactions whereas the electron delocalization from lone pair on the carbonyl oxygen to antibonding C-H orbital is facilitated by hydrogen bonding.	Hydrogen	244-252	spindlin 1	Homo sapiens	9-13
27336283-4	2016	The spin-spin coupling mechanism transmits spin polarization via electric field effect originating from lp---pi interactions whereas the electron delocalization from lone pair on the carbonyl oxygen to antibonding C-H orbital is facilitated by hydrogen bonding.	Hydrogen	244-252	spindlin 1	Homo sapiens	9-13
27336283-5	2016	It has been demonstrated that indirect spin-spin coupling constants across the hydrogen bonds correlate linearly with hydrogen bond distances.	Hydrogen	79-87	spindlin 1	Homo sapiens	39-43
27336283-5	2016	It has been demonstrated that indirect spin-spin coupling constants across the hydrogen bonds correlate linearly with hydrogen bond distances.	Hydrogen	79-87	spindlin 1	Homo sapiens	44-48
27336283-5	2016	It has been demonstrated that indirect spin-spin coupling constants across the hydrogen bonds correlate linearly with hydrogen bond distances.	Hydrogen	118-126	spindlin 1	Homo sapiens	39-43
27336283-5	2016	It has been demonstrated that indirect spin-spin coupling constants across the hydrogen bonds correlate linearly with hydrogen bond distances.	Hydrogen	118-126	spindlin 1	Homo sapiens	44-48
27167503-2	2016	We report on fragment screening by high-throughput docking to the BRPF1 bromodomain which resulted in six chemotypes with very favorable ligand efficiency (0.45-0.50 kcal/mol per non-hydrogen atom).	Hydrogen	183-191	bromodomain and PHD finger containing 1	Homo sapiens	66-71
27032648-0	2016	Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants.	Hydrogen	0-8	Nef	Human immunodeficiency virus 1	111-114
26980806-6	2016	of inducible NO synthase (iNOS) protein and its mRNA (NOS2) in cultured epithelial cells isolated from the ampulla were stimulated by EDN1, but not by EDN2 or EDN3, after 1h of incubation.	Hydrogen	171-173	nitric oxide synthase 2	Bos taurus	3-24
26980806-6	2016	of inducible NO synthase (iNOS) protein and its mRNA (NOS2) in cultured epithelial cells isolated from the ampulla were stimulated by EDN1, but not by EDN2 or EDN3, after 1h of incubation.	Hydrogen	171-173	nitric oxide synthase 2	Bos taurus	26-30
26980806-6	2016	of inducible NO synthase (iNOS) protein and its mRNA (NOS2) in cultured epithelial cells isolated from the ampulla were stimulated by EDN1, but not by EDN2 or EDN3, after 1h of incubation.	Hydrogen	171-173	nitric oxide synthase 2	Bos taurus	54-58
26980806-6	2016	of inducible NO synthase (iNOS) protein and its mRNA (NOS2) in cultured epithelial cells isolated from the ampulla were stimulated by EDN1, but not by EDN2 or EDN3, after 1h of incubation.	Hydrogen	171-173	endothelin 1	Bos taurus	134-138
27431536-5	2016	Ligand-based pharmacophore models (LBPMs) were developed for two kinases: ADPR.14 (r(2)train = 0.809) for Syk, comprising one hydrogen bond acceptor, one hydrogen bond donor, one positive ionisable and one ring aromatic feature, and for PI3Kdelta: AAARR.45 (r(2)train = 0.942) consisting of three hydrogen bond acceptor and two ring aromatic features.	Hydrogen	126-134	spleen associated tyrosine kinase	Homo sapiens	106-109
27431536-5	2016	Ligand-based pharmacophore models (LBPMs) were developed for two kinases: ADPR.14 (r(2)train = 0.809) for Syk, comprising one hydrogen bond acceptor, one hydrogen bond donor, one positive ionisable and one ring aromatic feature, and for PI3Kdelta: AAARR.45 (r(2)train = 0.942) consisting of three hydrogen bond acceptor and two ring aromatic features.	Hydrogen	154-162	spleen associated tyrosine kinase	Homo sapiens	106-109
27431536-5	2016	Ligand-based pharmacophore models (LBPMs) were developed for two kinases: ADPR.14 (r(2)train = 0.809) for Syk, comprising one hydrogen bond acceptor, one hydrogen bond donor, one positive ionisable and one ring aromatic feature, and for PI3Kdelta: AAARR.45 (r(2)train = 0.942) consisting of three hydrogen bond acceptor and two ring aromatic features.	Hydrogen	154-162	spleen associated tyrosine kinase	Homo sapiens	106-109
27147456-6	2016	Ciraparantag is a reversal agent under development for reversal of anticoagulation with direct and indirect FXa inhibitors and certain factor IIa inhibitors; it exerts its effect through hydrogen bonding.	Hydrogen	187-195	coagulation factor X	Homo sapiens	108-111
27198225-3	2016	Here we describe a mutation in mouse and human Bak that specifically disrupts its interaction with the prosurvival protein Bcl-xL Substitution of Glu75 in mBak (hBAK Q77) for leucine does not affect the three-dimensional structure of Bak or killing activity but reduces its affinity for Bcl-xL via loss of a single hydrogen bond.	Hydrogen	315-323	BCL2 antagonist/killer 1	Homo sapiens	47-50
26774606-2	2016	Multidisciplinary approaches that include hydrogen/deuterium exchange mass spectrometry (DXMS) and computational techniques have been employed with great success in order to address important questions about the mode of interactions of PLA2 enzymes with membranes, phospholipid substrates and inhibitors.	Hydrogen	42-50	phospholipase A2 group IIA	Homo sapiens	236-240
26669707-5	2016	The docking simulation showed that compound 17 bound well into the active site of VEGFR-2 via two hydrogen bonds and hydrophobic interactions.	Hydrogen	98-106	kinase insert domain receptor	Homo sapiens	82-89
27064170-1	2016	We provide evidence that magnetic moments formed when hydrogen atoms are covalently bound to graphene exhibit spin glass ordering.	Hydrogen	54-62	spindlin 1	Homo sapiens	110-114
27064170-4	2016	Magnetotransport measurements at the Dirac point, and as a function of hydrogen concentration, demonstrate that the spin glass state is observable as the zero-field resistivity reaches a value close to the quantum unit h/2e(2), corresponding to the point at which the system undergoes a transition from weak to strong localization.	Hydrogen	71-79	spindlin 1	Homo sapiens	116-120
27014917-5	2016	The newly identified ALK inhibitors are found to have a little higher inhibitory activity for the L1196M mutant than for the wild type due to the strengthening of the hydrogen bond interactions in the ATP-binding site.	Hydrogen	167-175	ALK receptor tyrosine kinase	Homo sapiens	21-24
26275916-0	2016	Near-complete 1H, 13C, 15N resonance assignments of dimethylsulfoxide-denatured TGFBIp FAS1-4 A546T.	Hydrogen	14-16	transforming growth factor beta induced	Homo sapiens	80-86
26286319-0	2016	1H, 13C and 15N resonance assignments and secondary structure of the human PHF6-ePHD1 domain.	Hydrogen	0-2	PHD finger protein 6	Homo sapiens	75-79
26841790-8	2016	The hydrogen bond between heme propionates with CD3 or E10 residues were evidently influenced by B10/E7 mutation.	Hydrogen	4-12	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	97-100
26808198-7	2016	Itk and Btk SH3 underwent a clear EX1 cooperative unfolding event, which was localized using pepsin digestion and mass spectrometry after hydrogen exchange labeling.	Hydrogen	138-146	Bruton tyrosine kinase	Homo sapiens	8-11
26292150-5	2016	DNJ, C3G, and C3R could rupture intramolecular hydrogen bonds of GK to accelerate its allosteric activation at early stage.	Hydrogen	47-55	glucokinase	Homo sapiens	65-67
26912373-5	2016	Hydrogen treatment by annealing the CuWO4 NF film in mixed gases of H2 and Ar could further enhance the photoactivity, as hydrogen treatment significantly increased the electron density of CuWO4 by generating oxygen vacancy in the lattice.	Hydrogen	0-8	relaxin 2	Homo sapiens	68-77
26912373-5	2016	Hydrogen treatment by annealing the CuWO4 NF film in mixed gases of H2 and Ar could further enhance the photoactivity, as hydrogen treatment significantly increased the electron density of CuWO4 by generating oxygen vacancy in the lattice.	Hydrogen	122-130	relaxin 2	Homo sapiens	68-77
26979693-3	2016	Remarkably, the partial charge on the hydrogen atom of the optimized H3O(+) force field is 0.8 +- 0.1 e --significantly higher than the value typically used for nonpolarizable water models and H3O(+) force fields.	Hydrogen	38-46	H3 clustered histone 15	Homo sapiens	69-72
26979693-3	2016	Remarkably, the partial charge on the hydrogen atom of the optimized H3O(+) force field is 0.8 +- 0.1 e --significantly higher than the value typically used for nonpolarizable water models and H3O(+) force fields.	Hydrogen	38-46	H3 clustered histone 15	Homo sapiens	193-196
26766161-2	2016	Here, using scanning tunneling microscopy and spectroscopy (STM/STS) supported by theoretical modeling, we study the interaction of a planar organic molecule (trinaphthylene) with a hydrogen-passivated Ge(001):H substrate and a single dangling bond quantum dot on that surface.	Hydrogen	182-190	sulfotransferase family 1A member 3	Homo sapiens	60-63
26766161-3	2016	The electronic structure of the molecule adsorbed on the hydrogen-passivated surface is similar to the gas phase structure and the measurements show that HOMO and LUMO states contribute to the STM filled and empty state images, respectively.	Hydrogen	57-65	sulfotransferase family 1A member 3	Homo sapiens	193-196
26555264-4	2016	We identify a network of aromatic interactions and hydrogen bonds that regulates hMGL active-inactive state interconversion.	Hydrogen	51-59	monoglyceride lipase	Homo sapiens	81-85
26705611-8	2016	HE and CTB tracing showed that the survival rate of RGCs in the H2-treated group was significantly higher than the rate in the I/R group.	Hydrogen	64-66	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	7-10
26683671-0	2016	MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.	Hydrogen	67-75	heat shock protein family A (Hsp70) member 8	Homo sapiens	10-15
26683671-7	2016	Furthermore, Hsc70 expression was upregulated by H2 administration.	Hydrogen	49-51	heat shock protein family A (Hsp70) member 8	Homo sapiens	13-18
26683671-9	2016	In conclusion, H2 treatment can ameliorate the inflammatory response and reduce the expression of inflammatory mediators during the early phase of AP by inhibiting the MAPK pathways and increasing Hsc70 expression.	Hydrogen	15-17	heat shock protein family A (Hsp70) member 8	Homo sapiens	197-202
26869767-7	2016	Using a combination of experimental and theoretical modeling analysis, we found that XN can embed into the hydrophobic pocket of MD-2 and form two stable hydrogen bonds with residues ARG-90 and TYR-102 of MD-2.	Hydrogen	154-162	lymphocyte antigen 96	Homo sapiens	205-209
27489405-1	2016	The 1H nuclear magnetic resonance (NMR) spectra and the dipolar spin-lattice relaxation time T1D for 1H in the natural natrolite (Na2Al2Si3O10 2H2O) have been measured in the temperature range of 190-390 K. From the temperature transformations of 1H NMR spectra, it follows that at T &gt; 300 K, the diffusion of water molecules along the nano-channels is observed.	Hydrogen	101-103	spindlin 1	Homo sapiens	64-68
27489405-1	2016	The 1H nuclear magnetic resonance (NMR) spectra and the dipolar spin-lattice relaxation time T1D for 1H in the natural natrolite (Na2Al2Si3O10 2H2O) have been measured in the temperature range of 190-390 K. From the temperature transformations of 1H NMR spectra, it follows that at T &gt; 300 K, the diffusion of water molecules along the nano-channels is observed.	Hydrogen	101-103	spindlin 1	Homo sapiens	64-68
27131115-2	2016	These systems have very different hydrogen bond strengths: the OH   N C bonds in (mCP)2 are ~10 times stronger than the CH   N C hydrogen bonds in (BN)2.	Hydrogen	34-42	cleft palate 2	Mus musculus	82-87
27725410-9	2016	Furthermore, the LDL receptor (LDLR) levels were higher in the HF/HS+GT+Eri group (+50%, p&lt;0.05) than in the HF/HS group.	Hydrogen	66-68	low density lipoprotein receptor	Mus musculus	17-29
27725410-9	2016	Furthermore, the LDL receptor (LDLR) levels were higher in the HF/HS+GT+Eri group (+50%, p&lt;0.05) than in the HF/HS group.	Hydrogen	66-68	low density lipoprotein receptor	Mus musculus	31-35
26585176-9	2016	In silico studies demonstrate that DHMA formed hydrogen bond interaction with key residues Trp26, Phe55 and Lys24 by which it disrupt the binding of p53 with MDM2 receptor.	Hydrogen	47-55	MDM2 proto-oncogene	Homo sapiens	158-162
34884482-6	2021	When embedded into a hydrophobic polymer such as polyisobutylene, a largely different rheological behavior was observed for the barbiturate-bearing PB compared to the thiobarbiturate-bearing PTB polymers, indicative of a stronger hydrogen bonding in the thioanalogue PTB.	Hydrogen	230-238	polypyrimidine tract binding protein 1	Homo sapiens	191-194
34884482-6	2021	When embedded into a hydrophobic polymer such as polyisobutylene, a largely different rheological behavior was observed for the barbiturate-bearing PB compared to the thiobarbiturate-bearing PTB polymers, indicative of a stronger hydrogen bonding in the thioanalogue PTB.	Hydrogen	230-238	polypyrimidine tract binding protein 1	Homo sapiens	267-270
34940412-3	2021	In this research, the membrane biofilm reactor and hydrogen-based membrane biofilm reactor (MBR-MBfR) were optimized and regulated under different operating parameters: the simulated domestic sewage with low C/N was domesticated and the domestic sewage was then denitrified.	Hydrogen	51-59	translocator protein	Homo sapiens	92-95
34800952-0	2021	Focusing and spin polarization of atomic hydrogen beam.	Hydrogen	41-49	spindlin 1	Homo sapiens	13-17
34800952-1	2021	We have developed a spin-polarized-hydrogen beam with a hexapole magnet.	Hydrogen	35-43	spindlin 1	Homo sapiens	20-24
34743514-3	2021	Motivated by the need to bridge this capability gap, we report low-magnetic-field two-dimensional (2D) 1H nuclear spin relaxation measurements as a noninvasive probe of adsorbate identity and interfacial dynamics, exploring the relaxation characteristics exhibited by liquid hydrocarbon adsorbates confined to a model mesoporous silica.	Hydrogen	103-105	spindlin 1	Homo sapiens	114-118
34730581-0	2021	Steric effects in the hydrogen evolution reaction based on the TMX4 active center: Fe-BHT as a case study.	Hydrogen	22-30	thioredoxin related transmembrane protein 4	Homo sapiens	63-67
34783967-0	2022	1H, 13C and 15N resonance assignments and solution structures of the two RRM domains of Matrin-3.	Hydrogen	0-2	matrin 3	Homo sapiens	88-96
34835850-2	2021	Results showed that when applied with 10 mM EDC amination, the functional groups of NH2 were successfully added to GOx, according to the analysis of 1H-NMR, elemental composition, and FTIR spectra.	Hydrogen	149-151	hydroxyacid oxidase 1	Homo sapiens	115-118
34714626-0	2021	Kinetic Studies of the Hydrogen Atom Transfer in a Hypoxia-Sensing Enzyme, FIH-1: KIE and O2 Reactivity.	Hydrogen	23-31	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	75-80
34121768-9	2021	SARS-CoV2 nsp1 protein binds with the interface region of the palm and finger domain of POLA1 via hydrogen bonding and salt bridge interactions.	Hydrogen	98-106	SH2 domain containing 3A	Homo sapiens	10-14
34302797-2	2021	The first five carbon atoms of the sphingoid LCB, herein defined as the "sphingoid motif", are largely responsible for the unique chemical and biophysical properties of sphingolipids since they can undergo a relatively large number (compared to other lipid species) of molecular interactions with other membrane lipids, via hydrogen-bonding, charge-pairing, hydrophobic and van der Waals interactions.	Hydrogen	324-332	clathrin light chain B	Homo sapiens	45-48
34302797-5	2021	In the former, the selectivity of sphingolipid synthesis relies on a hydrogen bond interaction between Lys379 of SPTLC2 and the l-serine sidechain hydroxyl moiety.	Hydrogen	69-77	serine palmitoyltransferase long chain base subunit 2	Homo sapiens	113-119
34832880-0	2021	A Rational Design of alpha-Helix-Shaped Peptides Employing the Hydrogen-Bond Surrogate Approach: A Modulation Strategy for Ras-RasGRF1 Interaction in Neuropsychiatric Disorders.	Hydrogen	63-71	RAS protein-specific guanine nucleotide-releasing factor 1	Rattus norvegicus	127-134
34712574-2	2021	It is caused by bi-allelic loss-of-function mutations in SGSH encoding sulphamidase, a lysosomal enzyme required for heparan sulphate glycosaminoglycan (HS GAG) degradation, that results in the progressive build-up of HS GAGs in multiple tissues most notably the central nervous system (CNS).	Hydrogen	153-155	N-sulfoglucosamine sulfohydrolase	Homo sapiens	71-83
34721070-0	2021	A Comparison of the Antioxidant Effects Between Hydrogen Gas Inhalation and Vitamin C Supplementation in Response to a 60-Min Treadmill Exercise in Rat Gastrocnemius Muscle.	Hydrogen	48-56	gastrin	Rattus norvegicus	57-60
34721070-3	2021	It has been suggested that hydrogen gas, as an antioxidant, can selectively scavenge hydroxyl radicals but does not affect superoxide anion"s signal transduction.	Hydrogen	27-35	gastrin	Rattus norvegicus	36-39
34721070-4	2021	The aim of this study was to compare the effects of 1-h hydrogen gas inhalation 30min prior to a treadmill exercise on the key biomarkers of mitochondrial biogenesis and related signaling pathways, and the activities of endogenous antioxidant enzymes, with those of vitamin C, in the rat skeletal muscle.	Hydrogen	56-64	gastrin	Rattus norvegicus	65-68
34721070-10	2021	The findings indicated that hydrogen gas inhalation could play the role as an effective antioxidant in response to the exercise, whilst it did not significantly affect mitochondrial biogenesis.	Hydrogen	28-36	gastrin	Rattus norvegicus	37-40
34691352-15	2021	Both the relative expression levels of HO-1 and NQO1 proteins in skin specimens of cGVHD mice in the hydrogen group were lower than that in the nonhydrogen group (2.47 versus 6.21 and 1.83 versus 3.59, p < 0.05).	Hydrogen	101-109	NAD(P)H dehydrogenase, quinone 1	Mus musculus	48-52
34691352-16	2021	The relative expression level of caspase-3 protein in skin specimens of cGVHD mice increased to 7.17 on the 96th day after transplantation, significantly higher than 4.36 in the hydrogen group.	Hydrogen	178-186	caspase 3	Mus musculus	33-42
34508625-11	2021	Molecular docking analysis shows that ABL1 interacts with Cofilin1 mainly through hydrogen bonds and ionic interaction between amino acid residues.	Hydrogen	82-90	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	38-42
34546267-0	2021	Controllable synthesis of Ni3S2@MOOH/NF (M = Fe, Ni, Cu, Mn and Co) hybrid structure for the efficient hydrogen evolution reaction.	Hydrogen	103-111	neurofascin	Homo sapiens	37-39
34091333-6	2021	Results show that LBP/PVP-ZIF-67 exhibits excellent photothermal performance, and higher potential in electrochemical hydrogen evolution than bare LBP or LBP/PVP.	Hydrogen	118-126	lipopolysaccharide binding protein	Homo sapiens	147-150
34683244-2	2021	In this work, Ni was added together with TaF5 and VCl3 to increase the reaction rates with hydrogen and the hydrogen-storage capacity of Mg.	Hydrogen	91-99	TATA-box binding protein associated factor 5	Homo sapiens	41-45
34683244-2	2021	In this work, Ni was added together with TaF5 and VCl3 to increase the reaction rates with hydrogen and the hydrogen-storage capacity of Mg.	Hydrogen	108-116	TATA-box binding protein associated factor 5	Homo sapiens	41-45
34685028-0	2021	Features of Hydrogen Reduction of Fe(CN)63- Ions in Aqueous Solutions: Effect of Hydrogen Dissolved in Palladium Nanoparticles.	Hydrogen	12-20	general transcription factor IIE subunit 1	Homo sapiens	34-42
34685028-1	2021	Preliminary saturation of 2.6 nm palladium nanoparticles with hydrogen accelerates the reduction of Fe(CN)63- ions in aqueous solution three to four-fold.	Hydrogen	62-70	general transcription factor IIE subunit 1	Homo sapiens	100-108
34472828-0	2021	Hierarchical Nanostructured Co-Mo-B/CoMoO4-x Amorphous Composite for the Alkaline Hydrogen Evolution Reaction.	Hydrogen	82-90	sphingomyelin synthase 1	Homo sapiens	31-35
34472828-4	2021	Our study found that NaBH4 reduction of CoMoO4 resulted in the concurrent formation of amorphous Co-Mo-B and an O-vacancy-rich CoMoO4-x substrate, which cooperatively catalyzed the hydrogen evolution reaction (HER) in an alkaline electrolyte.	Hydrogen	181-189	sphingomyelin synthase 1	Homo sapiens	100-104
34612367-2	2021	By forming hydrogen bonds with 1,3-dicarbonyl structures, ureas can activate the substrates, stabilize the carbanion intermediates and the products, and fix the syn-configurations of 1,3-dicarbonyl structures.	Hydrogen	11-19	synemin	Homo sapiens	161-164
34435786-4	2021	Taken together with molecular dynamics (MD) simulation and three-dimensional (3D) structural network analysis of the receptor-ligand complex, the results indicated that the hydrogen bonding with Thr943.36 and His2727.43 could make a stable interaction between the 3"-amino group with TM3 and TM7, and the corresponding induced-fit effects may play important roles in rendering the agonistic effect.	Hydrogen	173-181	tropomyosin 3	Homo sapiens	284-287
34477699-4	2021	After a trace amount of W and Mo atoms was doped, the constructed W and Mo co-doped NiCoP nanorod arrays (W,Mo-NiCoP/NF) show a low overpotential of 249 mV towards the hydrogen evolution reaction (HER) at a very large current density of 1000 mA cm-2.	Hydrogen	168-176	neurofascin	Homo sapiens	117-119
34465779-3	2021	Using temperature-dependent (20 C-65 C) NMR relaxation dispersion, we show that m6A pairs with uridine with the methylamino group in the anti conformation to form a Watson-Crick base pair that transiently exchanges on the millisecond timescale with a singly hydrogen-bonded low-populated (1%) mismatch-like conformation in which the methylamino group is syn.	Hydrogen	258-266	synemin	Homo sapiens	354-357
34445210-13	2021	Fumarate and malate were increased after IR 1h in CA2-4,DG and this was reversed by betaIIV5-3 what correlated with GLS1 activity increases and earlier showed elevation of neuronal death (Krupska et al., 2017).	Hydrogen	44-46	carbonic anhydrase 2	Homo sapiens	50-53
34354069-2	2021	Using hydrogen deuterium exchange mass spectrometry, we find mouse lipin 1 binds membranes through an N-terminal amphipathic helix, the Ig-like domain and HAD phosphatase catalytic core, and a middle lipin (M-Lip) domain that is conserved in mammalian and mammalian-like lipins.	Hydrogen	6-14	lipin 1	Mus musculus	67-74
34181950-3	2021	Here, we use a wide range of cell biological, biochemical, and biophysical techniques, including hydrogen-deuterium exchange mass spectrometry, to investigate the mechanism of activation of Sgk3 by PI3P.	Hydrogen	97-105	serum/glucocorticoid regulated kinase family member 3	Homo sapiens	190-194
34312718-12	2021	Also, Arg371, which plays a crucial role in the activity of RXR, formed a strong hydrogen bond with B12; however, a weak interaction was elicited between Arg371 and berberine.	Hydrogen	81-89	retinoid X receptor alpha	Homo sapiens	60-63
34170102-9	2021	Because of the simple synthesis method and the enhanced catalytic performance and stability of NiO/NF, this allows methanol to be used as an OER masking agent for the energy-efficient generation of value-added products such as formic acid and hydrogen.	Hydrogen	243-251	neurofascin	Homo sapiens	99-101
34078074-0	2021	Heterostructured Ni3S2-Ni3P/NF as a Bifunctional Catalyst for Overall Urea-Water Electrolysis for Hydrogen Generation.	Hydrogen	98-106	neurofascin	Homo sapiens	28-30
34078074-5	2021	Thus, the Ni3S2-Ni3P/NF exhibits superior performance for both UOR and hydrogen evolution reaction (HER).	Hydrogen	71-79	neurofascin	Homo sapiens	21-23
34660846-4	2021	Glu attains alpha (3) and beta (4) crystal forms and Cbeta-CH2 show asymmetric 1H signal pattern in NMR spectra.	Hydrogen	79-81	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	53-62
34660846-11	2021	The Cbeta-CH2 geminal protons on the side chain of Glu have different chemical shifts and splitting pattern in 1H NMR reflecting their dissymmetric environment.	Hydrogen	111-113	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	4-13
34135948-8	2021	Furthermore, the new NiL2 complex was docked with plasma retinol-binding protein 4 (RBP4) (PDB id: 5NU7), which implied that the NiL2 complex bound to Tyrosine 133 and Aspartate 102 amino acids via N-H intermolecular hydrogen bonds.	Hydrogen	217-225	retinol binding protein 4	Homo sapiens	57-82
34070680-4	2021	Compounds 1c (IC50 = 18.09 +- 0.25 muM), 1h (IC50 = 4.14 +- 0.10 muM), and 2a (IC50 = 15.69 +- 0.40 muM) had greater mushroom tyrosinase-inhibitory activities than kojic acid (KA) (IC50 = 48.62 +- 3.38 muM).	Hydrogen	41-43	tyrosinase	Homo sapiens	126-136
34141088-1	2021	Retinoid X receptor (RXR) ligands often bind in modes in which the carboxy group forms a hydrogen bond inside the ligand-binding pocket (LBP).	Hydrogen	89-97	retinoid X receptor alpha	Homo sapiens	0-19
34141088-1	2021	Retinoid X receptor (RXR) ligands often bind in modes in which the carboxy group forms a hydrogen bond inside the ligand-binding pocket (LBP).	Hydrogen	89-97	retinoid X receptor alpha	Homo sapiens	21-24
34141088-1	2021	Retinoid X receptor (RXR) ligands often bind in modes in which the carboxy group forms a hydrogen bond inside the ligand-binding pocket (LBP).	Hydrogen	89-97	lipopolysaccharide binding protein	Homo sapiens	137-140
34067030-6	2021	Stern-Volmer fitted fluorescence quenching analysis, isothermal titration calorimetry analysis and in silico molecule docking showed valonea tannin non-selectively bound to the surface of tyrosinase via hydrogen bonds and hydrophobic interactions.	Hydrogen	203-211	tyrosinase	Homo sapiens	188-198
34257857-2	2021	In non-polar solvents, the combination of non-covalent hydrogen bonds and pi-pi-interactions induces the formation of the syn-isomer in up to 85% yield.	Hydrogen	55-63	synemin	Homo sapiens	122-125
34090694-0	2021	Protective effects of hydrogen gas against spinal cord ischemia-reperfusion injury.	Hydrogen	22-30	gastrin	Rattus norvegicus	31-34
34090694-1	2021	OBJECTIVE: This experimental study aimed to assess the efficacy of hydrogen gas inhalation against spinal cord ischemia-reperfusion injury and reveal its mechanism by measuring glutamate concentration in the ventral horn using an in vivo microdialysis method.	Hydrogen	67-75	gastrin	Rattus norvegicus	76-79
34746793-3	2021	In a longitudinal 7T magnetic resonance spectroscopy (1H-MRS), we quantified glutamate at the dorsal anterior cingulate cortex in 21 participants with a median lifetime antipsychotic exposure of less than 3 days and followed them up after 6 months of treatment.	Hydrogen	54-56	MROS	Homo sapiens	57-60
34749602-13	2021	Molecular dynamics simulations for binding YWHAB and YWHAZ were conducted, and the complex was predicted to be energetically and structurally stable through its 3 hydrogen-bond patterns.	Hydrogen	163-171	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	53-58
35597097-4	2022	A structural model reproducibly predicted a binding mode where the pyrrolo pyrimidine forms a hydrogen bonding network with Asp22 and the amide backbone NH of Ile23 in the adenosine binding pocket and the carboxylate forms hydrogen bonds to the amide backbone of Phe157 and Asp156, part of the oxyanion subsite of Mac1.	Hydrogen	94-102	integrin subunit alpha M	Homo sapiens	314-318
35616137-5	2022	In the present study, 1H nuclear magnetic resonance analysis revealed a significant association between RACK1 expression and the glycolysis/gluconeogenesis pathway.	Hydrogen	22-24	receptor for activated C kinase 1	Homo sapiens	104-109
35131498-2	2022	In this study, porous hetero-structured nanosheet electrocatalyst (NiO/Ni2P/NF), composed of crystalline NiO and Ni2P, is prepared via the in-situ acid etching and gas-phase phosphating method, and the obtained NiO/Ni2P/NF material is applied as efficient urea oxidation and hydrogen evolution catalyst for the overall splitting of urea-containing wastewaters.	Hydrogen	275-283	neurofascin	Homo sapiens	76-78
35131498-2	2022	In this study, porous hetero-structured nanosheet electrocatalyst (NiO/Ni2P/NF), composed of crystalline NiO and Ni2P, is prepared via the in-situ acid etching and gas-phase phosphating method, and the obtained NiO/Ni2P/NF material is applied as efficient urea oxidation and hydrogen evolution catalyst for the overall splitting of urea-containing wastewaters.	Hydrogen	275-283	neurofascin	Homo sapiens	220-222
35624145-3	2022	Thirteen kinases were found to activate sodium/hydrogen exchanger (NHE1) in normal hematopoietic progenitors, of which FLT3-ITD, KRASG12D, and BTK phosphorylated NHE1 maintained alkaline intracellular pH (pHi) and supported survival of AML cells.	Hydrogen	47-55	Bruton tyrosine kinase	Homo sapiens	143-146
35471498-4	2022	The optimized CS-NS/NF has excellent hydrogen production performance, with overpotentials of 335 and 394 mV at current densities of 500 and 1000 mA cm-2, respectively, as well as superior durability for over 68 h in 1 M KOH.	Hydrogen	37-45	neurofascin	Homo sapiens	14-22
35341785-0	2022	Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress.	Hydrogen	0-8	cytochrome b-245 beta chain	Rattus norvegicus	121-136
35341785-8	2022	Additionally, western blotting results showed that hydrogen inhalation inhibited the expression of cardiac nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2), angiotensin II type 1 receptor, sarcoplasmic reticulum Ca2+-ATPase (SERCA2), phospho-phospholamban and alpha-myosin heavy chain proteins.	Hydrogen	51-59	cytochrome b-245 beta chain	Rattus norvegicus	107-160
35341785-8	2022	Additionally, western blotting results showed that hydrogen inhalation inhibited the expression of cardiac nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2), angiotensin II type 1 receptor, sarcoplasmic reticulum Ca2+-ATPase (SERCA2), phospho-phospholamban and alpha-myosin heavy chain proteins.	Hydrogen	51-59	cytochrome b-245 beta chain	Rattus norvegicus	162-166
35452240-3	2022	Analysis of RAIR spectra changes after acetone exposure, and we find that more hydrogen bonding occurs between acetone and p-ASW ices as compared to acetone and np-ASW or CI ices.	Hydrogen	79-87	chromosome 2 open reading frame 49	Homo sapiens	125-128
35470777-4	2022	According to the data obtained, these compounds exhibit close modes of binding to the Abl kinase active site that are mainly provided by hydrogen bonds and multiple van der Waals contacts.	Hydrogen	137-145	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	86-89
35440135-1	2022	In the transition to decarbonized energy systems, Power-to-Gas (PtG) processes have the potential to connect the existing markets for electricity and hydrogen.	Hydrogen	150-158	protein phosphatase 1 regulatory subunit 3C	Homo sapiens	50-62
35383180-5	2022	We identify specific contacts between SUMO2 and the USPL1 subdomains, including a unique hydrogen bond network of the SUMO2 C-terminal tail.	Hydrogen	89-97	small ubiquitin like modifier 2	Homo sapiens	38-43
35383180-5	2022	We identify specific contacts between SUMO2 and the USPL1 subdomains, including a unique hydrogen bond network of the SUMO2 C-terminal tail.	Hydrogen	89-97	small ubiquitin like modifier 2	Homo sapiens	118-123
35431915-7	2022	Results: The results showed that Betanin constituted a stable complex with SENP2 active site as it revealed low RMSD, high binding energy, and hydrogen bonds.	Hydrogen	143-151	SUMO/sentrin specific peptidase 2	Mus musculus	75-80
35431915-8	2022	Further, as compared to Ebselen, Betanin demonstrated low toxicity, formed a stable complex with SENP2 via four to seven hydrogen bonds, and constituted more stable MD plots.	Hydrogen	121-129	SUMO/sentrin specific peptidase 2	Mus musculus	97-102
35364318-7	2022	Additionally, we find that elevated levels of calcium ions and glucose hinder the extensibility of tropoelastin by rearranging structural domains and altering hydrogen bonding patterns, respectively.	Hydrogen	159-167	elastin	Homo sapiens	99-111
35408869-5	2022	Compound 4o, which exhibited the strongest SHP2 inhibitory activity, bound directly to the catalytic domain of SHP2 in a competitive manner through multiple hydrogen bonds.	Hydrogen	157-165	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	111-115
35229097-2	2022	The rigidity, symmetry and high density of hydrogen bonding motifs make 1 an attractive candidate for self-assembly study, which revealed different hydrogen bond patterns in the crystals of rac-1-d3 and (+)-(SSS)-1.	Hydrogen	43-51	Rac family small GTPase 1	Homo sapiens	190-195
35229097-2	2022	The rigidity, symmetry and high density of hydrogen bonding motifs make 1 an attractive candidate for self-assembly study, which revealed different hydrogen bond patterns in the crystals of rac-1-d3 and (+)-(SSS)-1.	Hydrogen	148-156	Rac family small GTPase 1	Homo sapiens	190-195
35258781-9	2022	Moreover, RSV exhibited good binding affinity towards SphK1, with docking scores of -8.1 kcal/moL and formed hydrogen bonds with ASP-178 and LEU-268 in SphK1.	Hydrogen	109-117	sphingosine kinase 1	Rattus norvegicus	54-59
35258781-9	2022	Moreover, RSV exhibited good binding affinity towards SphK1, with docking scores of -8.1 kcal/moL and formed hydrogen bonds with ASP-178 and LEU-268 in SphK1.	Hydrogen	109-117	sphingosine kinase 1	Rattus norvegicus	152-157
35041942-3	2022	The intramolecular hydrogen bond between the 14-hydroxy and the 16-sulfonamide groups may play an important role in increasing the probability that the 6-amide group would be located at the lower side of the C-ring, leading to an active conformation for OX1R.	Hydrogen	19-27	hypocretin receptor 1	Homo sapiens	254-258
35018710-3	2022	It is theoretically found that silicon atoms in silicon-rich structures (especially MSi2 and MSi) show a strong site-isolating effect, which can eliminate M-M-M hollow and M-M bridge sites with too strong hydrogen-binding ability and thereby provide great opportunities for the exposure of novel highly active sites (e.g., M-top and Si-related sites).	Hydrogen	205-213	musashi RNA binding protein 2	Homo sapiens	84-88
35262078-4	2022	A structural model reproducibly predicted a binding mode where the pyrrolo pyrimidine forms a hydrogen bonding network with Asp 22 and the amide backbone NH of Ile 23 in the adenosine binding pocket and the carboxylate forms hydrogen bonds to the amide backbone of Phe 157 and Asp 156 , part of the oxyanion subsite of Mac1.	Hydrogen	94-102	integrin subunit alpha M	Homo sapiens	319-323
35143196-5	2022	Upon oxidation, the individual ZF domains unfold to various degrees, yielding a globular ZF456 peptide with ZF4 and ZF6, responsible for base-specific hydrogen bonds with 5S RNA, losing their betabetaalpha-folds.	Hydrogen	151-159	zinc finger protein 587	Homo sapiens	116-119
35143196-7	2022	In the presence of RNA, oxidation of the ZF456 peptide disrupts the key hydrogen bonding interactions between ZF5/ZF6 and 5S RNA.	Hydrogen	72-80	zinc finger and BTB domain containing 14	Homo sapiens	110-124
35172577-4	2022	The developed 2D-QSAR model showed five information rich molecular descriptors while the 3D-pharmacophore model of BCR-ABL showed five different chemical features (hydrogen bond acceptor, donor, hydrophobic group, positive ion group, and aromatic rings) and the HDAC model showed four different chemical features (hydrogen bond acceptor, donor, positive ion group, and aromatic rings) for potent BCR-ABL and HDAC inhibition.	Hydrogen	164-172	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	119-122
35172577-4	2022	The developed 2D-QSAR model showed five information rich molecular descriptors while the 3D-pharmacophore model of BCR-ABL showed five different chemical features (hydrogen bond acceptor, donor, hydrophobic group, positive ion group, and aromatic rings) and the HDAC model showed four different chemical features (hydrogen bond acceptor, donor, positive ion group, and aromatic rings) for potent BCR-ABL and HDAC inhibition.	Hydrogen	314-322	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	119-122
35051687-7	2022	Substitution to lysine in D29K resulted in an increased number of hydrogen bonds in the T1R2 receptor, while substitution to alanine in R43A ablated a polar interaction in the T1R3 receptor.	Hydrogen	66-74	taste 1 receptor member 2	Homo sapiens	88-92
35050292-4	2022	Molecular docking technique was used to prove that the stable inclusion complex of Fx and HP-gamma-CD could be formed by hydrogen bonding when the molar ratio of Fx to HP-gamma-CD was 1 : 2, and the binding energy was as low as -10.23 kcal mol-1.	Hydrogen	121-129	modifier of LPS-response 1	Mus musculus	240-245
34929727-0	2022	Strong CPL-active liquid crystal materials induced by intermolecular hydrogen-bonding interaction and a chirality induction mechanism.	Hydrogen	69-77	hephaestin	Homo sapiens	7-10
34929727-1	2022	A novel co-assembly material can emit strong CPL signals (lambdaem = 485 nm, glum = +0.076/-0.064) from an achiral AIE-active beta-cyanostilbene (CYS) liquid crystal dye through intermolecular hydrogen bond (HB) interaction and chirality induction after a rapid cooling quench treatment.	Hydrogen	193-201	hephaestin	Homo sapiens	45-48
35111810-3	2021	In addition, molecular docking studies were achieved, which showed that all the newly synthesized compounds are interacting with the active site region of the target enzymes, the targets UDP-N-acetylmuramatel-alanine ligase (MurC), and human lanosterol14alpha-demethylase, through hydrogen bonds and pi-stacked interactions.	Hydrogen	281-289	caveolae associated protein 4	Homo sapiens	225-229
35056680-2	2022	This structural motif as known for formic acid, the archetype of double hydrogen bridges, is present in the solid state of the IL 1-(carboxymethyl)pyridinium bis(trifluoromethylsulfonyl)imide (HOOC-CH2-py)(NTf2).	Hydrogen	72-80	nuclear transport factor 2	Homo sapiens	206-210
35041802-2	2022	This medication"s new phosphate lowering mechanism of action reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux by inhibition of the sodium/hydrogen exporter isoform 3 (NHE3).	Hydrogen	200-208	solute carrier family 9 member A3	Homo sapiens	229-233
27834138-11	2016	CONCLUSION: Human mRNA matches across miR sequences constitute a positionally similar matrix of canonical hydrogen-bonding reactivity.	Hydrogen	106-114	membrane associated ring-CH-type finger 8	Homo sapiens	38-41
26550694-7	2016	Recombinant Slit2 was injected intraperitoneally 1h before SBI.	Hydrogen	49-51	slit guidance ligand 2	Rattus norvegicus	12-17
26562067-1	2015	We are the first to report the synthesis of a new class of 2-cyanoarylacrylamide (2-CAA) derivatives and observe that the synthesized 2-CAA shows fluorescence properties due to the formation of a dimeric interaction of hydrogen bonds between carbonyl oxygens and amide hydrogens (C O   H-N-C O   H-N   ); i.e., dimers are linked through dimeric N-H   O hydrogen bonds.	Hydrogen	219-227	teashirt zinc finger homeobox 1	Homo sapiens	84-87
26562067-1	2015	We are the first to report the synthesis of a new class of 2-cyanoarylacrylamide (2-CAA) derivatives and observe that the synthesized 2-CAA shows fluorescence properties due to the formation of a dimeric interaction of hydrogen bonds between carbonyl oxygens and amide hydrogens (C O   H-N-C O   H-N   ); i.e., dimers are linked through dimeric N-H   O hydrogen bonds.	Hydrogen	219-227	teashirt zinc finger homeobox 1	Homo sapiens	136-139
26562067-1	2015	We are the first to report the synthesis of a new class of 2-cyanoarylacrylamide (2-CAA) derivatives and observe that the synthesized 2-CAA shows fluorescence properties due to the formation of a dimeric interaction of hydrogen bonds between carbonyl oxygens and amide hydrogens (C O   H-N-C O   H-N   ); i.e., dimers are linked through dimeric N-H   O hydrogen bonds.	Hydrogen	269-278	teashirt zinc finger homeobox 1	Homo sapiens	84-87
26562067-1	2015	We are the first to report the synthesis of a new class of 2-cyanoarylacrylamide (2-CAA) derivatives and observe that the synthesized 2-CAA shows fluorescence properties due to the formation of a dimeric interaction of hydrogen bonds between carbonyl oxygens and amide hydrogens (C O   H-N-C O   H-N   ); i.e., dimers are linked through dimeric N-H   O hydrogen bonds.	Hydrogen	269-278	teashirt zinc finger homeobox 1	Homo sapiens	136-139
26562067-1	2015	We are the first to report the synthesis of a new class of 2-cyanoarylacrylamide (2-CAA) derivatives and observe that the synthesized 2-CAA shows fluorescence properties due to the formation of a dimeric interaction of hydrogen bonds between carbonyl oxygens and amide hydrogens (C O   H-N-C O   H-N   ); i.e., dimers are linked through dimeric N-H   O hydrogen bonds.	Hydrogen	269-277	teashirt zinc finger homeobox 1	Homo sapiens	84-87
26562067-1	2015	We are the first to report the synthesis of a new class of 2-cyanoarylacrylamide (2-CAA) derivatives and observe that the synthesized 2-CAA shows fluorescence properties due to the formation of a dimeric interaction of hydrogen bonds between carbonyl oxygens and amide hydrogens (C O   H-N-C O   H-N   ); i.e., dimers are linked through dimeric N-H   O hydrogen bonds.	Hydrogen	269-277	teashirt zinc finger homeobox 1	Homo sapiens	136-139
2599775-3	1989	All compounds have two dissociable hydrogens, corresponding to carboxyl (pK1 = 2.35-2.84) and to terminal amino group (pK2 = 5.61-6.93); pK1 values show first an upward and then a downward trend with the increase in ring size; the opposite is true for pK2 values.	Hydrogen	35-44	prokineticin 1	Homo sapiens	73-76
2599775-3	1989	All compounds have two dissociable hydrogens, corresponding to carboxyl (pK1 = 2.35-2.84) and to terminal amino group (pK2 = 5.61-6.93); pK1 values show first an upward and then a downward trend with the increase in ring size; the opposite is true for pK2 values.	Hydrogen	35-44	prokineticin 1	Homo sapiens	137-140
2792084-8	1989	O-2 is hydrogen-bonded through a water molecule to an adjacent asymmetric unit.	Hydrogen	7-15	immunoglobulin kappa variable 1D-39	Homo sapiens	0-3
2775729-4	1989	The large downfield shift of the amino protons of A14 demonstrates protonation of the deoxyadenosine base at pH 5.8 such that the protonated X5(syn).A14(anti) pair is stabilized by two hydrogen bonds at low pH.	Hydrogen	185-193	synemin	Homo sapiens	144-147
2775729-10	1989	The NMR experimental parameters are consistent with formation of a pH-independent X5(syn).G14(anti) pair stabilized by two hydrogen bonds with the 1,N2-propano exocyclic adduct of X5(syn) located in the major groove.	Hydrogen	123-131	synemin	Homo sapiens	85-88
2775729-10	1989	The NMR experimental parameters are consistent with formation of a pH-independent X5(syn).G14(anti) pair stabilized by two hydrogen bonds with the 1,N2-propano exocyclic adduct of X5(syn) located in the major groove.	Hydrogen	123-131	synemin	Homo sapiens	183-186
2912730-1	1989	Photochemically-induced dynamic nuclear polarization was used to identify exposed amino-acid residues and to assign resonances in the 1H-NMR spectrum of Ca(II)-independent discharged (inactivated) aequorin.	Hydrogen	134-136	carbonic anhydrase 2	Homo sapiens	153-159
2720117-3	1989	The peptide backbone folds in a regular right-handed alpha-helix conformation, with six intramolecular i----(i + 4) hydrogen bonds, forming C13 rings.	Hydrogen	116-124	homeobox C13	Homo sapiens	140-143
2720843-5	1989	The hydrogen transfer from the beta-NADPH to the product, 17 alpha,20 beta-dihydroxypregn-4-en-3-one catalyzed by 20 beta-hydroxysteroid dehydrogenase was stereospecific, and the 4-pro-S-hydrogen of the nicotinamide moiety was transferred to the product.	Hydrogen	4-12	carbonyl reductase [NADPH] 1	Sus scrofa	114-150
3145631-12	1988	From these results, and those reported recently, we propose that binding of the 4"-X-C12H5Cl4 derivatives to the rat cytosolic Ah receptor is favored by increasing the electronegativity, lipophilicity and hydrogen bonding characteristics of the 4" substituent, whereas enzyme induction (both in vivo and in cultured rat hepatoma cells) is also governed by a fourth characteristic, the STERIMOL factor, which gives a measure of the width of the substituent.	Hydrogen	205-213	aryl hydrocarbon receptor	Rattus norvegicus	127-138
9945998-0	1988	Spin-polarized atomic hydrogen in very strong magnetic fields.	Hydrogen	22-30	spindlin 1	Homo sapiens	0-4
3207996-16	1988	Thus the mechanism of glucokinase inhibition by alloxan and other inhibitors, such as uramil and ninhydrin, is an oxidation of functionally essential SH groups of the enzyme, where the most reactive keto group of the inhibitor acts as the hydrogen acceptor.	Hydrogen	239-247	glucokinase	Homo sapiens	22-33
3166426-7	1988	Removal of Ca2+ triggers a conformational change of the substrate recognition site because there is a direct connection, via secondary structure hydrogen bonds, between the Ca1 binding site and the substrate-recognition site.	Hydrogen	145-153	carbonic anhydrase 2	Homo sapiens	11-14
3166426-7	1988	Removal of Ca2+ triggers a conformational change of the substrate recognition site because there is a direct connection, via secondary structure hydrogen bonds, between the Ca1 binding site and the substrate-recognition site.	Hydrogen	145-153	carbonic anhydrase 1	Homo sapiens	173-176
3409879-6	1988	According to X-ray crystallographic data the OH group of the single tyrosine of calbindin (Tyr-13) is hydrogen-bonded to the carboxyl group of Glu-35, thus linking the two alpha helices flanking the N-terminal Ca2+ site.	Hydrogen	102-110	calbindin 1	Bos taurus	80-89
3387219-6	1988	The 1H chemical shifts for the trans-syn thymine dimer unit of the decamer were found to be quite similar to those found for the trans-syn thymine dimer of TpT.	Hydrogen	4-6	synemin	Homo sapiens	37-40
3387219-6	1988	The 1H chemical shifts for the trans-syn thymine dimer unit of the decamer were found to be quite similar to those found for the trans-syn thymine dimer of TpT.	Hydrogen	4-6	synemin	Homo sapiens	135-138
3415976-1	1988	Rabbit skeletal muscle troponin C (TnC) was investigated by means of 1H NMR in the presence of dithiothreitol that prevents dimerization of the protein.	Hydrogen	69-71	tenascin	Oryctolagus cuniculus	23-33
3415976-1	1988	Rabbit skeletal muscle troponin C (TnC) was investigated by means of 1H NMR in the presence of dithiothreitol that prevents dimerization of the protein.	Hydrogen	69-71	tenascin	Oryctolagus cuniculus	35-38
3125548-1	1988	Prostaglandin G/H synthase (8,11,14-icosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.1) catalyzes the first step in the formation of prostaglandins and thromboxanes, the conversion of arachidonic acid to prostaglandin endoperoxides G and H. This enzyme is the site of action of nonsteroidal anti-inflammatory drugs.	Hydrogen	52-60	thioredoxin reductase 1	Homo sapiens	74-88
26682380-4	2015	Results reveal that the optimized conditions for CNF production were 1000 W reaction power, 35 min radiation time, and 0.8 gas ratio of C2H2/H2.	Hydrogen	138-140	NPHS1 adhesion molecule, nephrin	Homo sapiens	49-52
3674882-1	1987	The structures of the oligosaccharides comprising the carbohydrate moieties of human prostatic acid phosphatase were elucidated by 1H NMR spectroscopy.	Hydrogen	131-133	acid phosphatase 3	Homo sapiens	85-111
26400077-1	2015	The de novo design of a beta/gamma-peptidic foldamer motif has led to the discovery of an unprecedented 9/8-ribbon featuring an uninterrupted alternating C9/C8 hydrogen-bonding network.	Hydrogen	160-168	complement C9	Homo sapiens	154-159
3427034-7	1987	For the GlcNAc(beta 1,2) linkage, complete agreement between all the observed NMR parameters and all the calculated ensemble average values could only be obtained with a set of potential energy functions which included hydrogen bonding.	Hydrogen	219-227	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	15-23
26344260-0	2015	A supramolecular structure insight for conversion property of cellulose in hot compressed water: Polymorphs and hydrogen bonds changes.	Hydrogen	112-120	alcohol dehydrogenase iron containing 1	Homo sapiens	75-78
3427034-9	1987	As a result, we infer that an interresidue hydrogen bond is formed, and we find it to be between the GlcNAc(beta 1,2) ring oxygen and the Man C3 hydroxyl.	Hydrogen	43-51	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	108-116
3624221-5	1987	The 1H and 13C nuclear magnetic resonance data indicated that imidazole C-2 of histidine is linked to C-6 of norleucine (epsilon-deaminated lysine residue) which in turn is linked to the C-6 amino group of hydroxylysine.	Hydrogen	4-6	complement C2	Bos taurus	72-75
26593892-4	2015	Thirty-six amino acid residues line the ligand binding pocket (LBP) and six of these residues have hydrogen-bonds linking with the ligand.	Hydrogen	99-107	lipopolysaccharide binding protein	Homo sapiens	63-66
2440473-1	1987	Hydrogen exchange rates of six beta-sheet peptide amide protons in bovine pancreatic trypsin inhibitor (BPTI) have been measured in free BPTI and in the complexes trypsinogen-BPTI, trypsinogen-Ile-Val-BPTI, bovine trypsin-BPTI, and porcine trypsin-BPTI.	Hydrogen	0-8	spleen trypsin inhibitor I	Bos taurus	104-108
26378231-2	2015	Two CRP residues, Thr(127) and Ser(128), are known to play important roles in cAMP binding through hydrogen bonding and in the cAMP-induced conformational change, but the connection between the two is not completely clear.	Hydrogen	99-107	catabolite gene activator protein	Escherichia coli	4-7
26378231-10	2015	Taken together, our analyses suggest that CRP evolved to have hydrogen bonding residues at the cAMP pocket residues 127 and 128 for performing dual functions: preserving high cAMP affinity and keeping CRP inactive in the absence of cAMP.	Hydrogen	62-70	catabolite gene activator protein	Escherichia coli	42-45
2883029-0	1987	A 1H-NMR study of the solution conformation of secretin.	Hydrogen	2-4	secretin	Homo sapiens	47-55
26378231-10	2015	Taken together, our analyses suggest that CRP evolved to have hydrogen bonding residues at the cAMP pocket residues 127 and 128 for performing dual functions: preserving high cAMP affinity and keeping CRP inactive in the absence of cAMP.	Hydrogen	62-70	catabolite gene activator protein	Escherichia coli	201-204
26427992-4	2015	A computational search for low energy geometries revealed that the syn isomer favors a six-membered ring hydrogen bond to nitrogen and the anti isomer favors a five-membered ring hydrogen bond to oxygen.	Hydrogen	105-113	synemin	Homo sapiens	67-70
2883029-2	1987	The solution conformation of the 27 residue polypeptide hormone secretin has been investigated by 1H-NMR spectroscopy under conditions where it adopts a fully ordered structure as judged by circular dichroism spectroscopy, namely in an aqueous solution of 40% (v/v) trifluoroethanol.	Hydrogen	98-100	secretin	Homo sapiens	64-72
2883029-3	1987	Using a combination of two-dimensional NMR techniques the 1H-NMR spectrum of secretin is completely assigned and its secondary structure is determined from a qualitative interpretation of the nuclear Overhauser enhancement data.	Hydrogen	58-60	secretin	Homo sapiens	77-85
3030298-0	1987	Role of carbohydrates in the viscosity and permeability of gastric mucin to hydrogen ion.	Hydrogen	76-84	mucin	Canis lupus familiaris	67-72
26460611-7	2015	Structure-based mutational analysis shows that distinct hydrogen bond networks of four FBG3 loops, i.e., beta2-beta3, beta5-beta6, beta7-beta8, and beta9-beta10, prevent the formation of the carbohydrate-binding pocket shown in Fbs1.	Hydrogen	56-64	F-box protein 44	Homo sapiens	87-91
26271894-0	2015	Hydrogen-rich water attenuates amyloid beta-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.	Hydrogen	0-8	sirtuin 1	Homo sapiens	89-94
3030298-1	1987	The effect of carbohydrate removal on the viscosity of gastric mucin and its ability to impede the diffusion of hydrogen ion was investigated.	Hydrogen	112-120	mucin	Canis lupus familiaris	63-68
3030298-5	1987	The ability of mucin to retard the diffusion of hydrogen ion increased by 7% following removal of fucose or N-acetylgalactosamine, a 28% increase was obtained following removal of sialic acid, while the permeability to hydrogen ion of the extensively deglycosylated glycoprotein decreased by 42%.	Hydrogen	48-56	mucin	Canis lupus familiaris	15-20
3030298-5	1987	The ability of mucin to retard the diffusion of hydrogen ion increased by 7% following removal of fucose or N-acetylgalactosamine, a 28% increase was obtained following removal of sialic acid, while the permeability to hydrogen ion of the extensively deglycosylated glycoprotein decreased by 42%.	Hydrogen	219-227	mucin	Canis lupus familiaris	15-20
31973392-3	2015	Specifically, sodium naphthalenide (Na-NAP) is used to capture H2 S to produce anhydrous Na2 S nanocrystals and 1,4-dihydronaphthalene, which are important materials for batteries and liquid fuels, respectively.	Hydrogen	63-65	catenin beta like 1	Homo sapiens	39-42
2948951-6	1987	A sixth protein, identified in nonreduced 125I-HSPG preparations, appeared as a non-HS chain-bearing Mr 35,000 peptide which was disulfide-linked to an HS chain-bearing peptide of similar size.	Hydrogen	84-86	syndecan 2	Homo sapiens	47-51
26291093-1	2015	Using inelastic electron tunneling spectroscopy with the scanning tunneling microscope (STM-IETS) and density functional theory calculations (DFT), we investigated properties of a single H2 molecule trapped in nanocavities with controlled shape and separation between the STM tip and the Au (110) surface.	Hydrogen	187-189	sulfotransferase family 1A member 3	Homo sapiens	88-91
26291093-1	2015	Using inelastic electron tunneling spectroscopy with the scanning tunneling microscope (STM-IETS) and density functional theory calculations (DFT), we investigated properties of a single H2 molecule trapped in nanocavities with controlled shape and separation between the STM tip and the Au (110) surface.	Hydrogen	187-189	sulfotransferase family 1A member 3	Homo sapiens	272-275
26323304-4	2015	The overall fold of CEACAM7 is similar to those of CEACAM1 and CEACAM5; however, there are differences, the most notable of which is an insertion that causes the C"" strand to buckle, leading to the creation of a hydrogen bond in the dimerization interface.	Hydrogen	213-221	CEA cell adhesion molecule 1	Homo sapiens	51-58
9897433-0	1986	Spin-polarized hydrogen maser.	Hydrogen	15-23	spindlin 1	Homo sapiens	0-4
3756304-8	1986	Since the ester compounds do not have hydrogen bond donating groups proximate to the aromatic ring, these results suggest a model for the A-T specificity of these compounds that involves a solvent-mediated hydrogen bond between the C-2 carbonyl of thymine and the carbonyl group of the intercalators.	Hydrogen	206-214	complement C2	Bos taurus	232-235
3719908-5	1986	The C-C(methyl) bonds are bent so that angles C(10)-C(1)-C(14) and C(13)-C(8)-C(15) are about 123 degrees, while the methyl groups are orientated with one hydrogen from each pointing away from the carbonyl group.	Hydrogen	155-163	homeobox C13	Homo sapiens	67-72
3719908-5	1986	The C-C(methyl) bonds are bent so that angles C(10)-C(1)-C(14) and C(13)-C(8)-C(15) are about 123 degrees, while the methyl groups are orientated with one hydrogen from each pointing away from the carbonyl group.	Hydrogen	155-163	placenta associated 8	Homo sapiens	78-83
3459148-4	1986	The spectrum of bound CaM is obtained indirectly from the difference spectrum between [1H]CaM X Mel and [2H]CaM X Mel.	Hydrogen	87-89	calmodulin 2	Gallus gallus	22-25
3459148-4	1986	The spectrum of bound CaM is obtained indirectly from the difference spectrum between [1H]CaM X Mel and [2H]CaM X Mel.	Hydrogen	87-89	calmodulin 2	Gallus gallus	90-93
3459148-4	1986	The spectrum of bound CaM is obtained indirectly from the difference spectrum between [1H]CaM X Mel and [2H]CaM X Mel.	Hydrogen	87-89	calmodulin 2	Gallus gallus	90-93
3707913-3	1986	The microenvironments of the histidines in three isoforms of Ca(II)-bound parvalbumin (carp, pI = 4.25; pike, pI = 5.00; rat, pI = 5.50) have been examined with 1H NMR techniques to probe their protonation characteristics and photochemically induced dynamic nuclear polarizability (photo-CIDNP).	Hydrogen	161-163	parvalbumin	Rattus norvegicus	74-85
3707913-11	1986	In contrast, His-48 in rat parvalbumin and His-106 in pike III parvalbumin show dramatic photo-CIDNP enhancements of their C2H, C5H, and beta-CH2 1H NMR resonances.	Hydrogen	146-148	parvalbumin	Rattus norvegicus	27-38
3707913-11	1986	In contrast, His-48 in rat parvalbumin and His-106 in pike III parvalbumin show dramatic photo-CIDNP enhancements of their C2H, C5H, and beta-CH2 1H NMR resonances.	Hydrogen	146-148	parvalbumin	Rattus norvegicus	63-74
3710691-2	1986	The conformation of the peptide Boc-L-Met-Aib-L-Phe-OMe has been studied in the solid state and solution by X-ray diffraction and 1H n.m.r., respectively.	Hydrogen	130-132	ANIB1	Homo sapiens	42-45
3792134-4	1986	The refinement of TnC at 2.2 A resolution highlights the intricate hydrogen-bonded network common to the Ca2+-bound loops and provides an explanation for the presence of a water molecule in the 5th coordination position of the Ca2+ ion.	Hydrogen	67-75	tenascin	Meleagris gallopavo	18-21
9896378-0	1985	Spin asymmetry in elastic scattering of electrons by hydrogen atoms.	Hydrogen	53-61	spindlin 1	Homo sapiens	0-4
2932103-0	1985	Two-dimensional 1H NMR studies of rat atrial natriuretic factor(1-23).	Hydrogen	16-18	natriuretic peptide A	Rattus norvegicus	38-63
26224609-2	2015	We describe the synthesis and stepwise activation of a new phosphane-pyridine-amide ligand PNN(H2) in combination with Rh(I) .	Hydrogen	95-97	pinin, desmosome associated protein	Homo sapiens	91-94
26325626-1	2015	In about 70% of patients affected by autosomal dominant osteopetrosis type 2 (ADO2), osteoclast activity is reduced by heterozygous mutations of the CLCN7 gene, encoding the ClC-7 chloride/hydrogen antiporter.	Hydrogen	189-197	chloride voltage-gated channel 7	Homo sapiens	149-154
26325626-1	2015	In about 70% of patients affected by autosomal dominant osteopetrosis type 2 (ADO2), osteoclast activity is reduced by heterozygous mutations of the CLCN7 gene, encoding the ClC-7 chloride/hydrogen antiporter.	Hydrogen	189-197	chloride voltage-gated channel 7	Homo sapiens	174-179
26207930-3	2015	The crystal structures of these complexes indicate that noncovalent interactions, such as hydrogen bonds, C-H   Cl, and pi   pi stacking, play essential roles in constructing the resulting supramolecular structures (1D for Hg3; 2D for Zn2, Hg2; 3D for Zn1, Hg1, and Zn3).	Hydrogen	90-98	polycystin 1, transient receptor potential channel interacting pseudogene 3	Homo sapiens	223-226
25840034-1	2015	OBJECTIVE: We aimed to prospectively derive and validate a novel 1h-algorithm using high-sensitivity cardiac troponin I (hs-cTnI) for early rule-out and rule-in of acute myocardial infarction.	Hydrogen	65-67	troponin I3, cardiac type	Homo sapiens	124-128
25840034-6	2015	After applying the hs-cTnI 1h-algorithm developed in the derivation cohort to the validation cohort, 50.5% of patients could be classified as "rule-out," 19% as "rule-in," 30.5% as "observe."	Hydrogen	27-29	troponin I3, cardiac type	Homo sapiens	22-26
26007660-4	2015	We report a 1.5 A crystal structure of aprataxin in a complex with GMP, which reveals that: (i) GMP binds at the same position and in the same anti nucleoside conformation as AMP; and (ii) aprataxin makes more extensive nucleobase contacts with guanine than with adenine, via a hydrogen bonding network to the guanine O6, N1, N2 base edge.	Hydrogen	278-286	aprataxin	Homo sapiens	39-48
26007660-4	2015	We report a 1.5 A crystal structure of aprataxin in a complex with GMP, which reveals that: (i) GMP binds at the same position and in the same anti nucleoside conformation as AMP; and (ii) aprataxin makes more extensive nucleobase contacts with guanine than with adenine, via a hydrogen bonding network to the guanine O6, N1, N2 base edge.	Hydrogen	278-286	aprataxin	Homo sapiens	189-198
26046591-6	2015	When connected together with the aid of an applied bias, the semiartificial cell demonstrated quantitative electron flow from photosystem II to the hydrogenase with the production of H2 and O2 being in the expected two-to-one ratio and a light-to-hydrogen conversion efficiency of 5.4% under low-intensity red-light irradiation.	Hydrogen	148-156	relaxin 2	Homo sapiens	183-192
25982075-9	2015	Molecular docking illustrated that urea moiety formed two critical hydrogen bonds with the DFG residues of VEGFR-2.	Hydrogen	67-75	kinase insert domain receptor	Homo sapiens	107-114
25978109-0	2015	Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial.	Hydrogen	0-8	ATP binding cassette subfamily A member 1	Homo sapiens	19-54
25978109-12	2015	CONCLUSIONS: H2 activates ATP-binding cassette transporter A1-dependent efflux, enhances HDL antiatherosclerotic functions, and has beneficial lipid-lowering effects.	Hydrogen	13-15	ATP binding cassette subfamily A member 1	Homo sapiens	26-61
4043925-3	1985	The results demonstrate that binding of steroid hormones to SHBG is facilitated by the 17 beta-hydroxyl group, possibly involving hydrogen binding, and by the methyl group at C-19 of the steroid moiety.	Hydrogen	130-138	sex hormone binding globulin	Bos taurus	60-64
26108284-2	2015	Here, using a combination of primarily small -angle X-ray scattering (SAXS) and hydrogen exchange mass spectrometry (HXMS) analysis, we describe an unexpectedly dynamic TTR protofibril structure which exchanges protomers with highly unfolded monomers in solution.	Hydrogen	80-88	transthyretin	Homo sapiens	169-172
26015162-3	2015	STH=solar-to-hydrogen energy conversion efficiency.	Hydrogen	13-21	saitohin	Homo sapiens	0-3
2986634-1	1985	Proton NMR and FTIR measurements have shown that the formation of stable, interbase hydrogen-bonded species of 5"-GMP in aqueous solutions of the tetramethylammonium salt can occur without the subsequent formation of ordered, slowly-exchanging structures or base stacking.	Hydrogen	84-92	5'-nucleotidase, cytosolic II	Homo sapiens	114-117
3160577-0	1985	1H NMR study of the interaction of bacteriophage lambda Cro protein with the OR3 operator.	Hydrogen	0-2	cro	Escherichia virus Lambda	56-59
26120483-9	2015	RESULTS: Lawsone and THN can be considered to efficiently bind with NOS, CAT, GSH, GR, G6PDH and NADPH, which has been confirmed through hydrogen bond affinity with the respective amino acids.	Hydrogen	137-145	glucose-6-phosphate dehydrogenase	Homo sapiens	87-92
25762024-5	2015	The (2-carboxyethyl)phenylethylamino group makes van der Waals contacts with side chains of amino acid residues Glu169(EL2), His264(EL3), Leu267(7.32), and Ile274(7.39), and the amine group forms a hydrogen bond with the side chain of Ser67(2.65).	Hydrogen	198-206	spectrin alpha, erythrocytic 1	Homo sapiens	119-122
4006876-1	1985	The 2H-NMR spectrum of the exchangeable hydrogens of the synthetic amphiphilic polypeptide, lys2-gly-leu24-lys2-ala-amide, was measured for the solid peptide at room temperature and, as a function of temperature, for the peptide incorporated into hydrated dipalmitoylphosphatidylcholine (DPPC) bilayers.	Hydrogen	40-49	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	92-96
25867032-1	2015	Addition of Co2(Co)9 and Ru3(CO)12 on preformed monodisperse iron(0) nanoparticles (Fe(0) NPs) at 150  C under H2 leads to monodisperse core-shell Fe@FeCo NPs and to a thin discontinuous Ru(0) layer supported on the initial Fe(0) NPs.	Hydrogen	111-113	phosphoserine phosphatase pseudogene 1	Homo sapiens	12-20
4006876-1	1985	The 2H-NMR spectrum of the exchangeable hydrogens of the synthetic amphiphilic polypeptide, lys2-gly-leu24-lys2-ala-amide, was measured for the solid peptide at room temperature and, as a function of temperature, for the peptide incorporated into hydrated dipalmitoylphosphatidylcholine (DPPC) bilayers.	Hydrogen	40-49	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	107-111
26263322-1	2015	We report that at ambient temperature and with 100% enriched para-hydrogen (p-H2) dissolved in organic solvents, paramagnetic spin catalysis of para   ortho hydrogen conversion is accompanied at the onset by a negative ortho-hydrogen (o-H2) proton NMR signal.	Hydrogen	61-74	polyhomeotic homolog 2	Homo sapiens	76-80
9895456-0	1985	Experimental study of the 2s and 2p populations of hydrogen atoms resulting from the interaction of 0.8-MeV/amu H+, H0, and H2 + projectiles with thin carbon foils.	Hydrogen	51-59	relaxin 2	Homo sapiens	116-126
26263322-1	2015	We report that at ambient temperature and with 100% enriched para-hydrogen (p-H2) dissolved in organic solvents, paramagnetic spin catalysis of para   ortho hydrogen conversion is accompanied at the onset by a negative ortho-hydrogen (o-H2) proton NMR signal.	Hydrogen	66-74	polyhomeotic homolog 2	Homo sapiens	76-80
26263322-1	2015	We report that at ambient temperature and with 100% enriched para-hydrogen (p-H2) dissolved in organic solvents, paramagnetic spin catalysis of para   ortho hydrogen conversion is accompanied at the onset by a negative ortho-hydrogen (o-H2) proton NMR signal.	Hydrogen	157-165	polyhomeotic homolog 2	Homo sapiens	76-80
6395890-0	1984	Escherichia coli single-stranded DNA binding protein is mobile on DNA: 1H NMR study of its interaction with oligo- and polynucleotides.	Hydrogen	71-73	single-stranded DNA-binding protein	Escherichia coli	17-52
25712385-2	2015	The purpose of this work was to explore whether agarose NGS coated with hydrogen-bonded layer-by-layer (HLbL) could provide an acellular method of delivering prolonged and consistent dosages of active BDNF.	Hydrogen	72-80	brain-derived neurotrophic factor	Rattus norvegicus	201-205
6395890-1	1984	The interaction of the Escherichia coli single-stranded DNA binding protein (SSB) with oligo- and poly-nucleotides has been studied by 270-MHz 1H NMR spectroscopy and fast kinetic techniques.	Hydrogen	143-145	single-stranded DNA-binding protein	Escherichia coli	40-75
6395890-1	1984	The interaction of the Escherichia coli single-stranded DNA binding protein (SSB) with oligo- and poly-nucleotides has been studied by 270-MHz 1H NMR spectroscopy and fast kinetic techniques.	Hydrogen	143-145	single-stranded DNA-binding protein	Escherichia coli	77-80
25749446-1	2015	We examined the effect of specific and local silencing of sodium/hydrogen exchanger isoform 1 (NHE1) with a small hairpin RNA delivered by lentivirus (L-shNHE1) in the cardiac left ventricle (LV) wall of spontaneously hypertensive rats, to reduce cardiac hypertrophy.	Hydrogen	65-73	solute carrier family 9 member A1	Rattus norvegicus	95-99
6593701-3	1984	Assignments can be made from the H1 and H2 protons to their J-coupled neighbors (H2 and H3) within this main envelope by using 1H-1H correlated spectroscopy.	Hydrogen	127-129	relaxin 2	Homo sapiens	81-90
6593701-3	1984	Assignments can be made from the H1 and H2 protons to their J-coupled neighbors (H2 and H3) within this main envelope by using 1H-1H correlated spectroscopy.	Hydrogen	130-132	relaxin 2	Homo sapiens	81-90
6440265-9	1984	The NADPH-cytochrome c (P450) reductase of G6PD-deficient HL and HSF homogenates becomes lower than that of controls when endogenous G6PD and exogenous glucose 6-phosphate (G6P) and NADP+ are used as a hydrogen donor system in place of NADPH.	Hydrogen	202-210	glucose-6-phosphate dehydrogenase	Homo sapiens	43-47
25947291-7	2015	The conversion of LBHB to an ordinary hydrogen bond in the mutant KSI reduced the binding affinity for the steroid inhibitors by a factor of 8.1-11.	Hydrogen	38-46	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	66-69
25947291-9	2015	These results suggest that the amount of stabilization energy of the reaction intermediate provided by LBHB is small compared with that provided by an ordinary hydrogen bond in KSI.	Hydrogen	160-168	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	177-180
6315486-0	1983	Proton NMR measurements of hydrogen exchange at the C-3 position of 3-hydroxybutyrate in suspensions of rat liver mitochondria.	Hydrogen	27-35	complement C3	Rattus norvegicus	52-55
25874906-11	2015	After 1h pre-treatment with anti-GLUT1, a reduction of 41% cellular accumulation of glc-IONP was observed.	Hydrogen	6-8	solute carrier family 2 member 1	Homo sapiens	33-38
6312051-1	1983	Other peptide protons have been removed by exchange in the sample preparation [( 1H]S-peptide is added to deuterated S-protein in D2O), and also by exchange-out of the less protected protons in residues 1 to 19.	Hydrogen	81-83	vitronectin	Homo sapiens	117-126
25589393-3	2015	A number of novel polymer complexes of various anions of copper(II), cobalt(II), nickel(II) and uranyl(II) with N(4-(acrylamido)-2-hydroxy benzoic acid) (ABH) have been synthesized and characterized by elemental analysis, IR, 1H NMR, magnetic susceptibility measurements, electronic spin resonance, vibrational spectra and thermal analysis.	Hydrogen	226-228	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	154-157
25583709-9	2015	Structural modeling demonstrated that CX6 bound to CXCR4 through hydrogen bond interactions with Asp97 and Glu288.	Hydrogen	65-73	C-X-C motif chemokine receptor 4	Homo sapiens	51-56
6626503-9	1983	We suggest that the contrasting temperature dependence of the H2 and CH3 proton signals can be accounted for by regularly alternating syn and anti conformations of the 8-methyladenylic acid residues.	Hydrogen	62-64	synemin	Homo sapiens	134-137
25721090-1	2015	In this paper the three new narrow bandgap D-A conjugated copolymers P1, P2 and P3 based on different weak donor fused thiophene-imidazole containing derivatives and the same benzothiadiazole acceptor unit were synthesized by Stille cross-coupling polymerization and characterized by 1H NMR, elemental analysis, GPC, TGA, DSC.	Hydrogen	284-286	crystallin gamma F, pseudogene	Homo sapiens	69-82
11542460-6	1983	The escape of H2 from the atmosphere of the primitive Earth may have played a crucial role in the formation of reactive organic molecules such as CH (triple bond) C-CN or (CN)2, which can be considered as important prebiotic precursors.	Hydrogen	14-16	carnosine dipeptidase 2	Homo sapiens	163-176
25751593-1	2015	This paper describes the influence of the substitution of fluorine for hydrogen on the rate of charge transport by hole tunneling through junctions of the form Ag(TS)O2C(CH2)n(CF2)(m)T//Ga2O3/EGaIn, where T is methyl (CH3) or trifluoromethyl (CF3).	Hydrogen	71-79	ATPase H+ transporting accessory protein 1	Homo sapiens	176-179
25658518-1	2015	Remarkable hydrogen evolution reaction (HER) or superior oxygen evolution reaction (OER) catalyst has been applied in water splitting, however, utilizing a bifunctional catalyst for simultaneously generating H2 and O2 is still a challenging issue, which is crucial for improving the overall efficiency of water electrolysis.	Hydrogen	11-19	relaxin 2	Homo sapiens	208-217
25598207-6	2015	The intramolecular hydrogen bonds play a significant role in the stability of the 1 : 1 type complexes AnO2(HL)2(NO3)2 (L = DEHP(-)).	Hydrogen	19-27	anoctamin 2	Homo sapiens	103-107
25601566-1	2015	A recent hydrogen-deuterium exchange study of folding of the GroEL/GroES-dependent bacterial enzyme DapA has suggested that the DapA folding pathway when free in solution may differ from the folding pathway used in the presence of the GroEL/GroES chaperonin.	Hydrogen	9-17	heat shock protein family D (Hsp60) member 1	Homo sapiens	61-66
25601566-1	2015	A recent hydrogen-deuterium exchange study of folding of the GroEL/GroES-dependent bacterial enzyme DapA has suggested that the DapA folding pathway when free in solution may differ from the folding pathway used in the presence of the GroEL/GroES chaperonin.	Hydrogen	9-17	heat shock protein family D (Hsp60) member 1	Homo sapiens	235-240
25533401-3	2015	Molecular modeling studies predicted that the improved inhibitory activity is induced by additional hydrogen bonds between the nitrogen atom of the pyrrolidine ring and Arg48 and by an interaction between the dimethylamino-substituent of the pyrrolidine moiety and a relatively hydrophobic groove in the RAGE binding site.	Hydrogen	100-108	advanced glycosylation end-product specific receptor	Homo sapiens	304-308
25559742-3	2015	Docking investigation of 6g with FXa protein revealed that the pyrimidone ring of 6g formed a pi-pi interaction with the phenyl ring of Tyr99, and the carbonyl group in the P1 moiety formed multiple hydrogen bonds to Ser214 and Trp215.	Hydrogen	199-207	coagulation factor X	Homo sapiens	33-36
25636878-7	2015	Molecular docking simulation indicated that RA formed hydrogen bonds and hydrophobic interactions within the ATP binding pocket of VEGFR2 kinase domain.	Hydrogen	54-62	kinase insert domain receptor	Homo sapiens	131-137
25347203-5	2015	Finally, crystallographic studies of the Plk1 PBD in complex with peptidomimetics 8 and 22 (AB-103-5) revealed the presence of two hydrogen bond interactions responsible for their high binding affinity and selectivity.	Hydrogen	131-139	polo like kinase 1	Homo sapiens	41-45
26603928-8	2015	The top ranking molecule against IRHOM2 active site has a glide g-score of -12.565 kcal/mol and glide e-model score of -74.967 with 3 hydrogen bonds and 11 hydrophobic contacts.	Hydrogen	134-142	rhomboid 5 homolog 2	Homo sapiens	33-39
25377300-4	2015	In THP-1 cells, AMPKalpha1 was phosphorylated within 1h of menadione (15 muM)-triggered increases in [reactive oxygen species (ROS)]cyto, an effect which was followed by upregulation of PPARgamma and several of its target genes (PGC-1alpha, liver X receptor alpha [LXRalpha] and ATP-binding cassette subfamily A, member 1 [ABCA1]; 24-72 h), with these effects being blunted by co-administration of vitamin C (62.5 muM).	Hydrogen	53-55	ATP binding cassette subfamily A member 1	Homo sapiens	279-321
25377300-4	2015	In THP-1 cells, AMPKalpha1 was phosphorylated within 1h of menadione (15 muM)-triggered increases in [reactive oxygen species (ROS)]cyto, an effect which was followed by upregulation of PPARgamma and several of its target genes (PGC-1alpha, liver X receptor alpha [LXRalpha] and ATP-binding cassette subfamily A, member 1 [ABCA1]; 24-72 h), with these effects being blunted by co-administration of vitamin C (62.5 muM).	Hydrogen	53-55	ATP binding cassette subfamily A member 1	Homo sapiens	323-328
26294069-0	2015	Prediction of enzyme inhibition and mode of inhibitory action based on calculation of distances between hydrogen bond donor/acceptor groups of the molecule and docking analysis: An application on the discovery of novel effective PTP1B inhibitors.	Hydrogen	104-112	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	229-234
25426707-2	2014	Spin-coated films were characterized with FT-IR, and once exposed to an aqueous solution the film distends and starts acting as a membrane which controls the flow of ions and H2 gas.	Hydrogen	175-177	spindlin 1	Homo sapiens	0-4
25183649-14	2014	We predict that mutations in ArsA propagate changes in hydrogen bonding and salt bridges to the ArsA-ArsD interface that affect their interactions.	Hydrogen	55-63	arylsulfatase D	Homo sapiens	101-105
25337794-2	2014	Two water molecules on adjacent atop sites form a dimer through a hydrogen bond, and they rotate even at a substrate temperature of 5 K. Action spectroscopy using STM (STM-AS) for water dimer hopping allows us to obtain the vibrational spectrum of a single water dimer on Pt(111).	Hydrogen	66-74	sulfotransferase family 1A member 3	Homo sapiens	163-166
25337794-2	2014	Two water molecules on adjacent atop sites form a dimer through a hydrogen bond, and they rotate even at a substrate temperature of 5 K. Action spectroscopy using STM (STM-AS) for water dimer hopping allows us to obtain the vibrational spectrum of a single water dimer on Pt(111).	Hydrogen	66-74	sulfotransferase family 1A member 3	Homo sapiens	168-174
25343325-3	2014	Warming the photolyzed solutions gives platinacycle trans-Pt(CH2CH2PEt2)(PEt3)(Cl)2(4-tft) by hydrogen-atom abstraction from a PEt3 ligand and trans-Pt(PEt3)2(Cl)(4-tft) from net HOCl photoelimination.	Hydrogen	94-102	solute carrier family 25 member 5	Homo sapiens	61-71
24912720-5	2014	Morin was found to bind to tyrosinase at a single binding site mainly by hydrogen bonds and van der Waals forces.	Hydrogen	73-81	tyrosinase	Homo sapiens	27-37
25250884-8	2014	Molecular docking simulation showed that PD formed hydrogen bonds and hydrophobic interactions within the ATP binding pocket of VEGFR2 kinase domain.	Hydrogen	51-59	kinase insert domain receptor	Homo sapiens	128-134
25391987-6	2014	The photodegradation and H2 evolution rates of this samples are significantly higher than those of unmodified P25 sample under visible-light irradiation.	Hydrogen	25-27	tubulin polymerization promoting protein	Homo sapiens	110-113
25392916-6	2014	Comparison of 1H-15N-TROSY spectra of Ca2+-bound and free states for the spin labeled cTnC-cTnI binary constructs demonstrated the release and modest movement of the cTnI switch region (~10 A) away from the hydrophobic N-lobe of troponin C (cTnC) upon the removal of Ca2+.	Hydrogen	14-16	troponin I3, cardiac type	Homo sapiens	91-95
25392916-6	2014	Comparison of 1H-15N-TROSY spectra of Ca2+-bound and free states for the spin labeled cTnC-cTnI binary constructs demonstrated the release and modest movement of the cTnI switch region (~10 A) away from the hydrophobic N-lobe of troponin C (cTnC) upon the removal of Ca2+.	Hydrogen	14-16	troponin I3, cardiac type	Homo sapiens	166-170
25329687-3	2014	This photocatalytic behavior is completely different from that measured for Au/P25 (hydrogen evolution) and Cu/P25 (lower activity, but similar methane selectivity).	Hydrogen	84-92	tubulin polymerization promoting protein	Homo sapiens	76-82
24845874-4	2014	The proposed mechanism is that the fluorescence of the probe was quenched due to the effect from spin-orbit coupling of Hg2+ after the probe coordinated with Hg2+, and was proved by ESI-MS and 1H NMR analysis.	Hydrogen	193-195	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	120-123
24845874-4	2014	The proposed mechanism is that the fluorescence of the probe was quenched due to the effect from spin-orbit coupling of Hg2+ after the probe coordinated with Hg2+, and was proved by ESI-MS and 1H NMR analysis.	Hydrogen	193-195	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	158-161
25437506-1	2014	The correct positioning and orientation of an hydrogen bond acceptor (HBA) in the tail portion of the biaryl series of CRTh2 antagonists is a requirement for long receptor residence time.	Hydrogen	46-54	prostaglandin D2 receptor 2	Homo sapiens	119-124
25145967-4	2014	A terephthalamide unit provided a binding site for capturing a ditopic hydrogen-bonding guest when it adopted helically folded syn forms (M/P).	Hydrogen	71-79	synemin	Homo sapiens	127-130
7115677-3	1982	The 1H NMR data show that all the br8G residues in these dimers take a syn glycosidic conformation.	Hydrogen	4-6	synemin	Homo sapiens	71-74
25145767-2	2014	The STM manipulations demonstrate the feasibility of switching such weak-hydrogen-bonding patterns.	Hydrogen	73-81	sulfotransferase family 1A member 3	Homo sapiens	4-7
6284311-2	1982	Cyclic AMP enhanced both the amplitude and duration of this inhibitory histamine response (H2-response), while cyclic GMP depressed the H2-response.	Hydrogen	136-138	5'-nucleotidase, cytosolic II	Homo sapiens	118-121
25392107-8	2014	HS induced an increase in CD4(+) and CD8(+) T cells in the jejunum and ileum compared with the NS group.	Hydrogen	0-2	Cd4 molecule	Rattus norvegicus	26-29
7110118-0	1982	1H Fourier transform nuclear magnetic resonance relaxation rate studies on the interaction of acetanilide with purified isozymes of rabbit liver microsomal cytochrome P-450 and with cytochrome b5.	Hydrogen	0-2	cytochrome b5	Oryctolagus cuniculus	182-195
24036313-1	2014	X-ray cocrystallographic studies of the human vitamin D receptor (hVDR)-[2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxyvitamin D3 (O1C3)] complex showed that the terminal hydroxy group of the 2alpha-functional group of O1C3 formed a hydrogen bond with Arg274 in the ligand binding domain (LBD) of hVDR to stabilize the complex; therefore, O1C3 showed 3-times greater binding affinity for VDR than the natural hormone.	Hydrogen	231-239	vitamin D receptor	Homo sapiens	46-64
24036313-1	2014	X-ray cocrystallographic studies of the human vitamin D receptor (hVDR)-[2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxyvitamin D3 (O1C3)] complex showed that the terminal hydroxy group of the 2alpha-functional group of O1C3 formed a hydrogen bond with Arg274 in the ligand binding domain (LBD) of hVDR to stabilize the complex; therefore, O1C3 showed 3-times greater binding affinity for VDR than the natural hormone.	Hydrogen	231-239	vitamin D receptor	Homo sapiens	66-70
24234100-0	1982	Use of hydrogen-sensitive Pd-MOS materials in biochemical analysis.	Hydrogen	7-15	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	29-32
24036313-1	2014	X-ray cocrystallographic studies of the human vitamin D receptor (hVDR)-[2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxyvitamin D3 (O1C3)] complex showed that the terminal hydroxy group of the 2alpha-functional group of O1C3 formed a hydrogen bond with Arg274 in the ligand binding domain (LBD) of hVDR to stabilize the complex; therefore, O1C3 showed 3-times greater binding affinity for VDR than the natural hormone.	Hydrogen	231-239	vitamin D receptor	Homo sapiens	67-70
24036313-4	2014	X-ray cocrystallographic analysis of the hVDR-1a complex showed new hydrogen bond formation between one of the nitrogen atoms of the tetrazole ring and Arg274.	Hydrogen	68-76	vitamin D receptor	Homo sapiens	41-45
7141529-3	1982	All compounds exhibited the (M-OH)+ ion, for which the hydrogen abstraction is non-specific, involving the C-2 and C-3 positions in the methylbutyl homolog.	Hydrogen	55-63	complement C3	Homo sapiens	115-118
25745269-0	2014	Hydrogen Bonding: HOC=O     H-N vs. HOC=O     H-C. A chloroform-soluble dipyrrinone, 8,9-bis-(5-carboxypentyl)-2,3-bis-(2-methoxyethoxy)-10H-dipyrrin-1-one, with solubilizing 2-methoxyethoxy beta-substituents on the lactam ring and two hexanoic acid groups (one at C(9), the other at C(8) of the pyrrole ring) was synthesized for its ability to form intramolecular hydrogen bonds to the lactam unit from either carboxylic acid, whether in the syn-(Z) or anti-(Z) conformation.	Hydrogen	0-8	synemin	Homo sapiens	314-317
25745269-1	2014	In the syn-(Z) conformation, such intramolecular hydrogen bonds can also include the pyrrole N-H.	Hydrogen	49-57	synemin	Homo sapiens	7-10
25745269-2	2014	In the anti-(Z), intramolecular hydrogen bonds can include the pyrrole C(7)-H. Evidence for both monomer conformations in equilibrium is provided by 1H NMR analyses, which indicate that the syn-(Z) is favored over the anti-(Z) and predict an interconversion barrier of approximately 40 kJ mol-1.	Hydrogen	32-40	synemin	Homo sapiens	190-193
25745269-2	2014	In the anti-(Z), intramolecular hydrogen bonds can include the pyrrole C(7)-H. Evidence for both monomer conformations in equilibrium is provided by 1H NMR analyses, which indicate that the syn-(Z) is favored over the anti-(Z) and predict an interconversion barrier of approximately 40 kJ mol-1.	Hydrogen	149-151	synemin	Homo sapiens	190-193
7141529-4	1982	In the same compound, the M-propene ion required the specific transfer of hydrogen from C-3.	Hydrogen	74-82	complement C3	Homo sapiens	88-91
7028115-26	1981	(7) These results indicate that the important hydrogen bonding positions involved in sugar interaction with the insulin-stimulated adipocytes transporter are the ring oxygen, C-1 and C-3.	Hydrogen	46-54	complement C3	Rattus norvegicus	175-186
25117572-0	2014	Hot carriers in epitaxial graphene sheets with and without hydrogen intercalation: role of substrate coupling.	Hydrogen	59-67	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
6273348-5	1981	Studies of the model compounds Z-Aib-Aib-Ala-NHMe, and Z-Aib-Aib-Aib-Pro-OMe clearly establish the presence of intramolecular hydrogen bonds, involving the urethane CO group.	Hydrogen	126-134	ANIB1	Homo sapiens	33-36
25014588-6	2014	Hydrogen/deuterium exchange mass spectrometry revealed that the peptide-based inhibitors target KDM4C through substrate-independent interactions located on the surface remote from the active site within less conserved regions of KDM4C.	Hydrogen	0-8	lysine demethylase 4C	Homo sapiens	96-101
25014588-6	2014	Hydrogen/deuterium exchange mass spectrometry revealed that the peptide-based inhibitors target KDM4C through substrate-independent interactions located on the surface remote from the active site within less conserved regions of KDM4C.	Hydrogen	0-8	lysine demethylase 4C	Homo sapiens	229-234
6273348-5	1981	Studies of the model compounds Z-Aib-Aib-Ala-NHMe, and Z-Aib-Aib-Aib-Pro-OMe clearly establish the presence of intramolecular hydrogen bonds, involving the urethane CO group.	Hydrogen	126-134	ANIB1	Homo sapiens	37-40
6273348-5	1981	Studies of the model compounds Z-Aib-Aib-Ala-NHMe, and Z-Aib-Aib-Aib-Pro-OMe clearly establish the presence of intramolecular hydrogen bonds, involving the urethane CO group.	Hydrogen	126-134	ANIB1	Homo sapiens	37-40
24993155-2	2014	Among the synthesized compounds, four biaryls 6a-d showed inhibition (IC50 58-75 muM) against in vitro PTP-1B assay possibly due to interaction with amino acid residues Lys120, Tyr46 through hydrogen bonding and aromatic-aromatic interactions, respectively.	Hydrogen	191-199	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	103-109
6273348-5	1981	Studies of the model compounds Z-Aib-Aib-Ala-NHMe, and Z-Aib-Aib-Aib-Pro-OMe clearly establish the presence of intramolecular hydrogen bonds, involving the urethane CO group.	Hydrogen	126-134	ANIB1	Homo sapiens	37-40
6273348-5	1981	Studies of the model compounds Z-Aib-Aib-Ala-NHMe, and Z-Aib-Aib-Aib-Pro-OMe clearly establish the presence of intramolecular hydrogen bonds, involving the urethane CO group.	Hydrogen	126-134	ANIB1	Homo sapiens	37-40
6273348-7	1981	In Z-Aib-Aib-Pro-OMe, where a 4 leads to 1 hydrogen bonded beta-turn is not possible, the benzylic-CH2-protons appear as a singlet in CDCl3 and have a very small chemical shift difference in (CD3)2SO.	Hydrogen	43-51	ANIB1	Homo sapiens	5-8
6273348-7	1981	In Z-Aib-Aib-Pro-OMe, where a 4 leads to 1 hydrogen bonded beta-turn is not possible, the benzylic-CH2-protons appear as a singlet in CDCl3 and have a very small chemical shift difference in (CD3)2SO.	Hydrogen	43-51	ANIB1	Homo sapiens	9-12
7342594-2	1981	The interaction of copper(II) with inosine derivatives substituted at the purine ring, modified at the ribose residue, and with the syn conformation at the glycosidic bond was examined using 1H and 13C nuclear magnetic resonance techniques.	Hydrogen	191-193	synemin	Homo sapiens	132-135
25043026-4	2014	Here we devised a strategy for forming and purifying a functional human beta2AR-beta-arrestin-1 complex that allowed us to visualize its architecture by single-particle negative-stain electron microscopy and to characterize the interactions between beta2AR and beta-arrestin 1 using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and chemical crosslinking.	Hydrogen	283-291	adrenoceptor beta 2	Homo sapiens	72-79
7336139-9	1981	The data support the concept that in man release of secretin is governed principally by the amount of hydrogen ions emptied into duodenum and indicate the importance of secretin in the late postprandial period, when the acidity of the gastric contents is high.	Hydrogen	102-110	secretin	Homo sapiens	52-60
25098771-6	2014	Cell-specific rescue experiments showed that different HS biosynthetic and modification enzymes can be provided cell-nonautonomously by different tissues to allow kal-1-dependent branching of AIY.	Hydrogen	55-57	uncharacterized protein	Caenorhabditis elegans	163-168
6969094-1	1980	A study has been made by means of 1H-NMR spectroscopy of the syn in equilibrium anti dynamic equilibrium about the glycosidic bond for 5"-deoxyadenosine and some 8-substituted analogues, in different solvents.	Hydrogen	34-36	synemin	Homo sapiens	61-64
24915880-4	2014	We have previously examined the influence of hydrogen-bonding oxo-substitutents on the P-gp-mediated efflux of 4,5-epoxymorphinan analgesics, as well as that of N-substituted analogues of meperidine.	Hydrogen	45-53	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	87-91
25098178-4	2014	Similarly to bovine lactoglobulin (BLG), conformation of the EF loop is stabilized by hydrogen bond between Glu89 and Ser116 indicating that Tanford transition might occur with the same mechanism.	Hydrogen	86-94	beta-lactoglobulin	Bos taurus	35-38
6969094-8	1980	It is shown that the proposed stabilization of the conformation syn by intramolecular hydrogen bonding, 5"-OH...N(3), is not in accord with the results of the present study.	Hydrogen	86-94	synemin	Homo sapiens	64-67
6107249-1	1980	Assignment and analysis of the 1H and 13C high resolution NMR spectra of somatostatin in aqueous solution.	Hydrogen	31-33	somatostatin	Homo sapiens	73-85
25089244-6	2014	Further, our analysis revealed that major active compounds bacoside A3 and A interact with different residues of TPH through hydrogen bond.	Hydrogen	125-133	tryptophan hydroxylase 1	Rattus norvegicus	113-116
7408842-1	1980	The syn in equilibrium anti equilibrium conformation about the glycosidic bond of purine nucleosides and 5"-nucleotides in different solvent systems has been investigated by means of 1H NMR spectroscopy.	Hydrogen	183-185	synemin	Homo sapiens	4-7
24981731-4	2014	The exchange of hydrogen versus fluorine on the peripheral phenyl groups show a notable influence on both the electronic and crystallographic natures of the resulting TTFs: 1) lowering both the HOMO and the LUMO energy levels, 2) modulating the electrochemical properties by regioselective and/or the degree of fluorination, 3) enhancing the driving forces of stacking by multiple fluorine interactions (F   S, C F   pi/piF , C F   F C, and C F   H).	Hydrogen	16-24	complement factor H	Homo sapiens	426-448
24909783-2	2014	A hydrogen/deuterium exchange (HDX) mass-spectrometry-based investigation of TATA box-binding protein (TBP) interaction with various domains of progesterone receptor (PR) demonstrate that agonist-bound PR interaction with TBP via AF1 impacts the mobility of the C-terminal AF2.	Hydrogen	2-10	TATA-box binding protein	Homo sapiens	77-101
40811-0	1979	Stereospecificity of hydrogen transfer of aldehyde reductase.	Hydrogen	21-29	aldo-keto reductase family 1 member A1	Homo sapiens	42-60
24909783-2	2014	A hydrogen/deuterium exchange (HDX) mass-spectrometry-based investigation of TATA box-binding protein (TBP) interaction with various domains of progesterone receptor (PR) demonstrate that agonist-bound PR interaction with TBP via AF1 impacts the mobility of the C-terminal AF2.	Hydrogen	2-10	TATA-box binding protein	Homo sapiens	103-106
24909783-2	2014	A hydrogen/deuterium exchange (HDX) mass-spectrometry-based investigation of TATA box-binding protein (TBP) interaction with various domains of progesterone receptor (PR) demonstrate that agonist-bound PR interaction with TBP via AF1 impacts the mobility of the C-terminal AF2.	Hydrogen	2-10	TATA-box binding protein	Homo sapiens	222-225
40811-1	1979	Aldehyde reductase from human liver catalyzes the hydrogen transfer from the pro-4R position on the dihydronicotinamide ring of the coenzyme to the re face of the carbonyl carbon atom of the substrate.	Hydrogen	50-58	aldo-keto reductase family 1 member A1	Homo sapiens	0-18
24755647-0	2014	1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity.	Hydrogen	0-2	stearoyl-CoA desaturase	Rattus norvegicus	75-79
156997-0	1979	A 1H NMR study of the syn-anti dynamic equilibrium in adenine nucleosides and nucleotides with the aid of some synthetic model analogues with fixed conformations.	Hydrogen	2-4	synemin	Homo sapiens	22-25
24952065-4	2014	Docking results suggest that crizotinib was found to adopt the most promising conformations to the native-type ALK by identifying the M1199 residue as a prospective partner for making a hydrogen bond as compared to the mutant-type ALK.	Hydrogen	186-194	ALK receptor tyrosine kinase	Homo sapiens	111-114
156997-1	1979	The syn-anti equilibrium about the glycosidic bond in adenosine and some related analogues was studied by means of 1H NMR spectroscopy, with the aid of several model analogues fixed in given conformations either by intramolecular bonding, or by introduction of a bulky substituent.	Hydrogen	115-117	synemin	Homo sapiens	4-7
18699536-0	1979	Pneumatic hydrogen pellet injection system for the ISX tokamak.	Hydrogen	10-18	intestine specific homeobox	Homo sapiens	51-54
24793011-2	2014	This study was aimed at discovery of such a radioligand from a group of CRF1 receptor ligands based on a core 3-(phenylamino)-pyrazin-2(1H)-one scaffold.	Hydrogen	136-138	corticotropin releasing hormone receptor 1	Rattus norvegicus	72-76
249314-4	1978	In the crude preparation, Co-EIF-1 exists in two molecular forms: Co-EIF-1H (Mr = 200,000) and Co-EIF-1L (Mr = 20,000).	Hydrogen	73-75	eukaryotic translation initiation factor 1	Oryctolagus cuniculus	29-34
744000-5	1978	NADPH was five times as effective a hydrogen donor as NADH when the washed microsomal fraction was the source of the enzyme.	Hydrogen	36-44	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
24985634-1	2014	We have recorded infrared spectra of acetyl radical (CH3CO) and CH3-CO complex in solid para-hydrogen (p-H2).	Hydrogen	88-101	polyhomeotic homolog 2	Homo sapiens	103-107
24756311-8	2014	The hydrogen bond strength of OH   O (FS) is stronger than that of SH   O (FC), resulting in a more compact gamma turn structure.	Hydrogen	4-12	shadow of prion protein	Homo sapiens	67-73
23288-12	1977	The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9.	Hydrogen	301-309	vitronectin	Homo sapiens	4-13
24898959-5	2014	Three modes of hydrogen bonding are described, characterized in part by the distance between contiguous O atoms: normal (NHB; O   O = 2.6-3.0 A), charge assisted (CAHB; O   O = 2.5 A) and molecular (MHB; O   O = 2.4 A).	Hydrogen	15-23	MHB	Homo sapiens	199-202
23288-12	1977	The S-protein is less stable to acid than RNase-A since the former, but not the latter, shows evidence of reversible denaturation at pH 3 and 26 degrees C. His-48 in S-protein titrates normally and has a lower pK than in RN-ase-A probably because of the absence of Asp-14, which in RN-ase-A forms a a hydrogen bond with His-48 and causes it to be inaccessible to solvent, at pH values below 9.	Hydrogen	301-309	vitronectin	Homo sapiens	166-175
974086-3	1976	Application of a strong radio-frequency field H2 at a frequency of 0.9 ppm or 1.7 ppm downfield from the proton resonance of 2,2-dimethyl-2-silapentane-5-sulfonate results in a negative NOE for the H2-2 proton resonance of ADP in its complex with creatine kinase.	Hydrogen	46-48	relaxin 2	Homo sapiens	198-202
181253-5	1976	Steady-state and transient kinetic experiments have shown that the hydrogen transfer step is rate-determining for oxidation of ethanol by carboxymethylated alcohol dehydrogenase.	Hydrogen	67-75	aldo-keto reductase family 1 member A1	Homo sapiens	156-177
24857932-8	2014	Western blot analysis of SDS/PAGE-fractionated tyrosine-nitrated proteins showed that L5 SNL led to increased expression of tyrosine-nitrated Mn-containing superoxide dismutase (MnSOD) in the spinal cord, and hydrogen-rich normal saline administration reversed the tyrosine-nitrated MnSOD overexpression.	Hydrogen	209-217	superoxide dismutase 2	Rattus norvegicus	178-183
240709-0	1975	Hydrogen-exchange study of the conformational stability of human carbonic-anhydrase B and its metallocomplexes.	Hydrogen	0-8	carbonic anhydrase 2	Homo sapiens	65-85
24786515-2	2014	H2 permeated by 1.18 x 10(-12) mol m m(-2) s(-1) Pa(-1) with a high selectivity (Falpha: 23.5 for H2/CO and 48.0 for H2/CH4) through its 2D-channels having a minimum diameter of 2.6 A, which is narrower than the Lennard-Jones diameter of H2 (2.827 A), CO (3.690 A), and CH4 (3.758 A).	Hydrogen	0-2	relaxin 2	Homo sapiens	98-103
24700693-0	2014	Hydrogen bonding switches the spin state of diphenylcarbene from triplet to singlet.	Hydrogen	0-8	spindlin 1	Homo sapiens	30-34
240709-1	1975	In the range of pH 4.6--8.8, 25 degrees C, the apoenzyme of carbonic anhydrase B shows no evidence of any gross conformational changes, as studied by the hydrogen-deuterium exchange method.	Hydrogen	154-162	carbonic anhydrase 2	Homo sapiens	60-80
1156576-11	1975	Exhaustive incubation of the tritiated malate (3-H/14-C = 1.95) with fumarase to labilize the pro-R hydrogen at C-3 resulted in release of 65% of the tritium into water.	Hydrogen	100-108	fumarate hydratase	Homo sapiens	69-77
24811617-1	2014	Liquid para-hydrogen (p-H2) is a typical quantum liquid which exhibits strong nuclear quantum effects (NQEs) and thus anomalous static and dynamic properties.	Hydrogen	7-20	polyhomeotic homolog 2	Homo sapiens	22-26
1156576-11	1975	Exhaustive incubation of the tritiated malate (3-H/14-C = 1.95) with fumarase to labilize the pro-R hydrogen at C-3 resulted in release of 65% of the tritium into water.	Hydrogen	100-108	complement C3	Homo sapiens	112-115
24811617-2	2014	We propose a real-time simulation method of wave packet (WP) molecular dynamics (MD) based on non-empirical intra- and inter-molecular interactions of non-spherical hydrogen molecules, and apply it to condensed-phase p-H2.	Hydrogen	165-173	polyhomeotic homolog 2	Homo sapiens	217-221
24811617-4	2014	The developed MD simulation for 100 ps with 1200 hydrogen molecules is realized at feasible computational cost, by which basic experimental properties of p-H2 liquid such as radial distribution functions, self-diffusion coefficients, and shear viscosities are all well reproduced.	Hydrogen	49-57	polyhomeotic homolog 2	Homo sapiens	154-158
4447491-0	1974	Hydrogen-deuterium exchange in the genetic variants A, B and C of bovine beta-lactoglobulin.	Hydrogen	0-8	beta-lactoglobulin	Bos taurus	73-91
24632442-9	2014	In addition, hydrogen bond network at the interface of the two monomers plays a part in stabilizing TTR dimer.	Hydrogen	13-21	transthyretin	Homo sapiens	100-103
4521798-1	1974	The effects of hydrogen ion concentrations on the carbon-13 nuclear magnetic resonance spectra of oxytocin were investigated.	Hydrogen	15-23	oxytocin/neurophysin I prepropeptide	Homo sapiens	98-106
24618260-13	2014	Finally, we found that H(2) could regulate the polarization of CD4+ T cells and the level of related cytokines.	Hydrogen	23-27	CD4 antigen	Mus musculus	63-66
4795867-0	1973	Mechanism of squalene cyclization: the chiral origin of the C-7 and C-15 hydrogen atoms of fusidic acid.	Hydrogen	73-81	placenta associated 8	Homo sapiens	68-72
24722458-6	2014	It was found that the nucleotides usually take correct syn/anti configurations when they form native and stable hydrogen bonds with the others, while fluctuating between two configurations when they do not.	Hydrogen	112-120	synemin	Homo sapiens	55-58
4403574-0	1972	The stereochemistry of hydrogen transfer from NADPH catalysed by 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver.	Hydrogen	23-31	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	65-112
24699146-10	2014	The analysis of binding poses of the top-ranked compounds docked to biotin carboxylase isoforms suggests that: (1) binding of the amino-oxazole anchor is stabilized by a network of hydrogen bonds to residues 201, 202 and 204; (2) halogenated aromatic moieties attached to the amino-oxazole scaffold enhance interactions with a hydrophobic pocket formed by residues 157, 169, 171 and 203; and (3) larger substituents reach deeper into the binding pocket to form additional hydrogen bonds with the side chains of residues 209 and 233.	Hydrogen	181-189	methylcrotonyl-CoA carboxylase subunit 2	Homo sapiens	68-86
24699146-10	2014	The analysis of binding poses of the top-ranked compounds docked to biotin carboxylase isoforms suggests that: (1) binding of the amino-oxazole anchor is stabilized by a network of hydrogen bonds to residues 201, 202 and 204; (2) halogenated aromatic moieties attached to the amino-oxazole scaffold enhance interactions with a hydrophobic pocket formed by residues 157, 169, 171 and 203; and (3) larger substituents reach deeper into the binding pocket to form additional hydrogen bonds with the side chains of residues 209 and 233.	Hydrogen	472-480	methylcrotonyl-CoA carboxylase subunit 2	Homo sapiens	68-86
23315337-0	2014	1H, 13C, and 15N chemical shift assignments of the phosphotyrosine binding domain 2 (PTB2) of human FE65.	Hydrogen	0-2	polypyrimidine tract binding protein 1	Homo sapiens	85-89
23315337-0	2014	1H, 13C, and 15N chemical shift assignments of the phosphotyrosine binding domain 2 (PTB2) of human FE65.	Hydrogen	0-2	amyloid beta precursor protein binding family B member 1	Homo sapiens	100-104
23361378-0	2014	1H, 13C, and 15N resonance assignments of mouse lipocalin-type prostaglandin D synthase/substrate analog complex.	Hydrogen	0-2	prostaglandin D2 synthase (brain)	Mus musculus	48-87
5280529-4	1971	A critical role is played by the asparagine residue: its peptide N-H participates in the formation of the hydrogen-bonded cyclic structure of the beta-turn in the ring component of oxytocin and its peptide C=O can be hydrogen-bonded to the N-H of tyrosine, while its side chain C=O stabilizes the second beta-turn by forming a hydrogen bond with the N-H of the leucine residue, which is part of the end peptide of the second beta-turn.	Hydrogen	106-114	oxytocin/neurophysin I prepropeptide	Homo sapiens	181-189
5280529-4	1971	A critical role is played by the asparagine residue: its peptide N-H participates in the formation of the hydrogen-bonded cyclic structure of the beta-turn in the ring component of oxytocin and its peptide C=O can be hydrogen-bonded to the N-H of tyrosine, while its side chain C=O stabilizes the second beta-turn by forming a hydrogen bond with the N-H of the leucine residue, which is part of the end peptide of the second beta-turn.	Hydrogen	217-225	oxytocin/neurophysin I prepropeptide	Homo sapiens	181-189
5280529-4	1971	A critical role is played by the asparagine residue: its peptide N-H participates in the formation of the hydrogen-bonded cyclic structure of the beta-turn in the ring component of oxytocin and its peptide C=O can be hydrogen-bonded to the N-H of tyrosine, while its side chain C=O stabilizes the second beta-turn by forming a hydrogen bond with the N-H of the leucine residue, which is part of the end peptide of the second beta-turn.	Hydrogen	217-225	oxytocin/neurophysin I prepropeptide	Homo sapiens	181-189
5280529-5	1971	This conformational assignment of oxytocin is consistent with hydrogen-deuterium exchange studies, with plots of temperature dependence of peptide proton chemical shifts, and with the coupling constants for the NH-CH dihedral angles.	Hydrogen	62-70	oxytocin/neurophysin I prepropeptide	Homo sapiens	34-42
5522466-0	1970	Hydrogen exchange as a probe of conformation of tobacco mosaic virus and its coat protein.	Hydrogen	0-8	Coat protein	Tobacco mosaic virus	77-89
24486339-5	2014	ECs treated with oxLDL or the P2Y2R agonists ATP/UTP for 1h exhibited significant reactive oxygen species (ROS) production, but this effect was not observed in P2Y2R siRNA-transfected ECs.	Hydrogen	57-59	purinergic receptor P2Y2	Homo sapiens	30-35
24566103-0	2014	DCo(H2)ding the metabolic functions of SIRT1 in the intestine.	Hydrogen	4-6	sirtuin 1	Homo sapiens	39-44
5783476-3	1969	In accordance with this view it is shown that in the conversion of [2RS-(3)H(2)]mevalonic acid into cholesterol one of the hydrogen atoms at C-15 is removed.	Hydrogen	123-131	placenta associated 8	Homo sapiens	141-145
24531000-5	2014	We found that a novel intermolecular hydrogen-bond network of S163 that glues adjacent globular heads of C1QTNF5 together was weakened or abolished by the R163 pathogenic mutation.	Hydrogen	37-45	C1q and TNF related 5	Homo sapiens	105-112
5783476-4	1969	A mechanism for the removal of the 14alpha-methyl group in steroid biosynthesis that involves the labilization of a C-15 hydrogen atom is outlined.	Hydrogen	121-129	placenta associated 8	Homo sapiens	116-120
5639923-5	1968	The location of five of the six labelled hydrogen atoms at C-3, C-9, C-18 and C-19 (two) confirms that the mechanism of cyclization of squalene expected from the biogenetic isoprene rule is functioning in vivo.	Hydrogen	41-49	complement C3	Homo sapiens	59-62
24677230-5	2014	A bifunctional activation model of the chiral Zn(OTf)2/bis(oxazoline) complex was proposed based on control experiments, wherein the ZnII moiety serves as a Lewis acid and the N atom of the free NH group acts as a Lewis base by a hydrogen-bonding interaction.	Hydrogen	230-238	POU class 2 homeobox 2	Homo sapiens	49-54
5639923-5	1968	The location of five of the six labelled hydrogen atoms at C-3, C-9, C-18 and C-19 (two) confirms that the mechanism of cyclization of squalene expected from the biogenetic isoprene rule is functioning in vivo.	Hydrogen	41-49	complement C9	Homo sapiens	64-67
4164898-6	1967	Inhibitor and spectrophotometric studies indicated that phosphorylation with hydrogen as electron donor occurs exclusively at a site in an abbreviated electron transport chain between H(2) and cytochrome b.	Hydrogen	77-85	mitochondrially encoded cytochrome b	Homo sapiens	193-205
24609064-5	2014	In our models, the KR residues of the motif occupy the P1" and P2" pockets of importin alpha, respectively, forming hydrogen-bonding and cation-pi interactions.	Hydrogen	116-124	crystallin gamma F, pseudogene	Homo sapiens	55-65
24480307-4	2014	The 5-LOX structure suggested association between Arg(101) in the beta-sandwich and Asp(166) in the catalytic domain, due to electrostatic interaction as well as hydrogen bonds.	Hydrogen	162-170	lysyl oxidase	Homo sapiens	6-9
5973206-0	1966	[Coenzyme B 12 as common hydrogen transferrer of dioldehydrase-and methylmalonyl-Co A -mutase reaction].	Hydrogen	25-33	methylmalonyl-CoA mutase	Homo sapiens	49-93
24530705-5	2014	Molecular docking study showed that NG binds in the outer surface site of BLG which is accompanied with three hydrogen bonds.	Hydrogen	110-118	beta-lactoglobulin	Bos taurus	74-77
24531484-9	2014	This may suggest a clue to a possible ADP/GDP-release pathway, because the NE1 atom of the Trp in the `DWG motif" of CK2alpha forms a hydrogen bond to the O atom of Leu212, which seems to make ADP release by means of the `DFG-in flip to DFG-out" model found in most eukaryotic protein kinases impossible.	Hydrogen	134-142	casein kinase 2 alpha 2	Homo sapiens	117-125
5833400-0	1965	Hydrogen-ion dependence of the antidiuretic action of vasopressin, oxytocin and deaminooxytocin.	Hydrogen	0-8	oxytocin/neurophysin I prepropeptide	Homo sapiens	67-75
24158589-10	2014	Notably, the number of hydrogen bonds in ERCC1-XPF mutant complexes decreased in the molecular dynamic simulation periods.	Hydrogen	23-31	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	47-50
24475979-3	2014	We proposed a hydrogen redox model to clarify the resistive switch mechanism of high/low resistance states (HRS/LRS) in carbon RRAM.	Hydrogen	14-22	leucyl-tRNA synthetase 1	Homo sapiens	112-115
14213378-0	1964	DIRECT HYDROGEN TRANSFER BY METHYLMALONYL COENZYME A MUTASE.	Hydrogen	7-15	methylmalonyl-CoA mutase	Homo sapiens	28-59
24188852-7	2014	This is probably because the orientation of cellulose chains on the film surface changes by the formation of numerous hydrogen bonds between cellulose molecules and MTM platelets.	Hydrogen	118-126	metallothionein 1D, pseudogene	Homo sapiens	165-168
33951550-2	2021	In a recent 1H MRS study, we reported increased GPC+PC in cortical and subcortical areas of adult patients with bipolar disorder I (BP-I).	Hydrogen	12-14	glycophorin C (Gerbich blood group)	Homo sapiens	48-51
24410860-0	2014	Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release.	Hydrogen	22-30	high mobility group box 1	Rattus norvegicus	117-122
24410860-2	2014	Hydrogen treatment was recently associated with down-regulation of the expression of HMGB1 and pro-inflammatory cytokines during sepsis and myocardial IRI, but it is not known whether hydrogen has an effect on HMGB1 in liver IRI.	Hydrogen	0-8	high mobility group box 1	Rattus norvegicus	85-90
24410860-10	2014	Hydrogen enriched saline treatment inhibited HMGB1 expression and release, reflecting a reduced local and systemic inflammatory response to hepatic ischemia reperfusion.	Hydrogen	0-8	high mobility group box 1	Rattus norvegicus	45-50
24055376-5	2014	As seen in the crystal structure of THp-(1-43) complexed with 14-3-3gamma, the region surrounding pSer19 adopts an extended conformation in the bound state, whereas THp-(1-43) adopts a bent conformation when free in solution, with higher content of secondary structure and higher number of internal hydrogen bonds.	Hydrogen	299-307	uromodulin	Homo sapiens	36-39
33964731-3	2021	Here we demonstrate a series of improved pulse sequences for 1H detection of spin-1/2 nuclei under fast MAS, with 195Pt SSNMR experiments on cisplatin as an example.	Hydrogen	61-63	spindlin 1	Homo sapiens	77-85
34054171-5	2021	FT-IR investigation revealed the existence of an intermolecular hydrogen bonding between PLA and SB, which led to an increased toughness in the PLAp-SB complex.	Hydrogen	64-72	phospholipase A2 activating protein	Homo sapiens	89-92
24739074-7	2014	The most important interactions for the binding of the inhibitors, which are probably also central components of the active site of KAT III, were identified as Ala134, Tyr135, Lys 280, Lys 288, Thr285 and Arg429, which provide hydrogen bond interactions.	Hydrogen	227-235	kynurenine aminotransferase 3	Homo sapiens	132-139
34054171-5	2021	FT-IR investigation revealed the existence of an intermolecular hydrogen bonding between PLA and SB, which led to an increased toughness in the PLAp-SB complex.	Hydrogen	64-72	phospholipase A2 activating protein	Homo sapiens	144-148
33904565-0	2021	Recasting Ni-foam into NiF2 nanorod arrays via a hydrothermal process for hydrogen evolution reaction application.	Hydrogen	74-82	zinc finger protein 335	Homo sapiens	23-27
24785112-2	2014	Three lichen depsidones, P1, P2 and P3, were isolated from H. physodes ME using column chromatography and their structures were determined by UV, ESI TOF MS, 1H and 13C NMR.	Hydrogen	158-160	crystallin gamma F, pseudogene	Homo sapiens	25-38
33904565-1	2021	A promising electrode for hydrogen evolution reaction (HER) has been prepared via a reduction process to form NiF2 nanorod arrays directly grown on a 3D nickel foam.	Hydrogen	26-34	zinc finger protein 335	Homo sapiens	110-114
33904565-2	2021	We reveal NiF2@Ni nanorod arrays for a stable hydrogen evolution reaction (HER) application.	Hydrogen	46-54	zinc finger protein 335	Homo sapiens	10-14
33582435-3	2021	During the heating process, the hydrogen bonding between side chain in P(NiPAAm-co-AAc) copolymer hydrogel and H2O was broken first, and then the formation of the intramolecular interaction in P(NiPAAm-co-AAc) copolymer hydrogel occurred.	Hydrogen	32-40	glycine-N-acyltransferase	Homo sapiens	83-86
24117897-7	2014	Treatment with H2 S abated MCD-diet-induced oxidative stress through reducing cytochrome p4502E1 expression, enhancing heme oxygenase-1 expression, and suppressing mitochondrial reactive oxygen species formation, and suppressed MCD-diet-induced inflammation through suppressing activated nuclear factor kappaB signaling and reducing interleukin-6 and tumor necrosis factor alpha expressions.	Hydrogen	15-17	heme oxygenase 1	Rattus norvegicus	119-135
24369353-3	2014	Here we determined the crystal structure of PKCzeta-PB1 in complex with a monomeric p62-PB1 mutant, where the massive electrostatic interactions between the acidic OPCA motif of PKCzeta-PB1 and the basic surface of p62-PB1, as well as additional hydrogen bonds, ensure the formation of a stable and specific complex.	Hydrogen	246-254	protein kinase C zeta	Homo sapiens	44-51
33582435-3	2021	During the heating process, the hydrogen bonding between side chain in P(NiPAAm-co-AAc) copolymer hydrogel and H2O was broken first, and then the formation of the intramolecular interaction in P(NiPAAm-co-AAc) copolymer hydrogel occurred.	Hydrogen	32-40	glycine-N-acyltransferase	Homo sapiens	205-208
24369353-3	2014	Here we determined the crystal structure of PKCzeta-PB1 in complex with a monomeric p62-PB1 mutant, where the massive electrostatic interactions between the acidic OPCA motif of PKCzeta-PB1 and the basic surface of p62-PB1, as well as additional hydrogen bonds, ensure the formation of a stable and specific complex.	Hydrogen	246-254	polybromo 1	Homo sapiens	52-55
24369353-3	2014	Here we determined the crystal structure of PKCzeta-PB1 in complex with a monomeric p62-PB1 mutant, where the massive electrostatic interactions between the acidic OPCA motif of PKCzeta-PB1 and the basic surface of p62-PB1, as well as additional hydrogen bonds, ensure the formation of a stable and specific complex.	Hydrogen	246-254	polybromo 1	Homo sapiens	88-91
33600050-1	2021	Mutations in the CLCN5 gene encoding the 2Cl- /1H+ exchanger ClC-5 are associated with Dent disease 1, an inherited renal disorder characterized by low molecular weight (LMW) proteinuria and hypercalciuria.	Hydrogen	47-49	chloride voltage-gated channel 5	Homo sapiens	17-22
24369353-3	2014	Here we determined the crystal structure of PKCzeta-PB1 in complex with a monomeric p62-PB1 mutant, where the massive electrostatic interactions between the acidic OPCA motif of PKCzeta-PB1 and the basic surface of p62-PB1, as well as additional hydrogen bonds, ensure the formation of a stable and specific complex.	Hydrogen	246-254	protein kinase C zeta	Homo sapiens	178-185
24369353-3	2014	Here we determined the crystal structure of PKCzeta-PB1 in complex with a monomeric p62-PB1 mutant, where the massive electrostatic interactions between the acidic OPCA motif of PKCzeta-PB1 and the basic surface of p62-PB1, as well as additional hydrogen bonds, ensure the formation of a stable and specific complex.	Hydrogen	246-254	polybromo 1	Homo sapiens	88-91
24369353-3	2014	Here we determined the crystal structure of PKCzeta-PB1 in complex with a monomeric p62-PB1 mutant, where the massive electrostatic interactions between the acidic OPCA motif of PKCzeta-PB1 and the basic surface of p62-PB1, as well as additional hydrogen bonds, ensure the formation of a stable and specific complex.	Hydrogen	246-254	nucleoporin 62	Homo sapiens	84-91
33964751-8	2021	Molecular modeling results implied that the dominant noncovalent interactions in the molecular recognition processes between hTTR and halogenated-thiophenols were ionic pair, hydrogen bonds and hydrophobic interactions.	Hydrogen	175-183	transthyretin	Homo sapiens	125-129
33739090-5	2021	The interaction networks of GDP and GTP with K-Ras are identified and the results uncover that the instability in hydrogen-bonding interactions of SW1 with GDP and GTP is mostly responsible for conformational disorder of SW1 and SW2 as well as tunes the activity of oncogenic K-Ras.	Hydrogen	114-122	KRAS proto-oncogene, GTPase	Homo sapiens	45-50
24791469-3	2014	Based on the data of spatial structure fluctuations, dynamics of hydrogen bonds and interaction energy of the CA1 and CA2, the most probable binding mode for these compounds with plant alpha-tubulin was identified and appropriate site of interaction was characterized.	Hydrogen	65-73	tubulin alpha-5	Arabidopsis thaliana	185-198
33739090-5	2021	The interaction networks of GDP and GTP with K-Ras are identified and the results uncover that the instability in hydrogen-bonding interactions of SW1 with GDP and GTP is mostly responsible for conformational disorder of SW1 and SW2 as well as tunes the activity of oncogenic K-Ras.	Hydrogen	114-122	KRAS proto-oncogene, GTPase	Homo sapiens	276-281
33647743-10	2021	Moreover, docking studies demonstrated the ability of compound 36 to bind VEGFR-2 in a correct manner making three essential hydrogen bonds with the key residues Glu885, Asp1046 and Cys919.	Hydrogen	125-133	kinase insert domain receptor	Homo sapiens	74-81
25206655-6	2013	Hydrogen proton magnetic resonance spectroscopy analysis showed that the N-acetylaspartate/creatine ratio in the hippocampal CA3 region was significantly increased at 1 week, and the N-acetylaspartate/choline ratio was significantly increased at 2 weeks after hyperbaric oxygen therapy.	Hydrogen	0-8	carbonic anhydrase 3	Rattus norvegicus	125-128
24100040-6	2013	Finally, we provide experimental evidence that FDX1 serves as the primary electron donor to two important biological pathways, NADPH and H2 photo-production, whereas FDX2 is capable of driving these reactions at less than half the rate observed for FDX1.	Hydrogen	137-139	ferredoxin 1	Homo sapiens	47-51
33849696-4	2021	Molecular docking results showed that compound 11c occupied a unique subpocket and formed a hydrogen bond with Glu1138 of TNKS2, which was not consistent with the patterns of known TNKS inhibitors and thus warrants further research.	Hydrogen	92-100	tankyrase 2	Homo sapiens	122-127
33876088-5	2021	Molecular dynamics simulations overrepresent the syn-conformation of guanine due to the overestimation of an intramolecular hydrogen bond.	Hydrogen	124-132	synemin	Homo sapiens	49-52
24290922-9	2013	The molecular docking and MD simulation studies showed that the sulfhydryl hydrogen atom of Cys17 of cysteine protease interacts with carboxylic oxygen of Lys16 of Abeta peptide indicating the cleavage site.	Hydrogen	75-83	cathepsin B	Homo sapiens	101-118
33157223-9	2021	RESULTS: Our preliminary results of pharmacophore model matching and molecular docking suggest that AST IV and protein tyrosine phosphatase 1B (PTP1B) can be well-combined through hydrogen bonding.	Hydrogen	180-188	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	111-142
24273343-2	2013	HF elimination across the CF2-CH2 junction is shown to be facilitated by an intramolecular hydrogen bond, while solvation is the key determinant in the stability of alcohols of various perfluoroalkyl lengths.	Hydrogen	91-99	ATPase H+ transporting accessory protein 1	Homo sapiens	26-29
33157223-9	2021	RESULTS: Our preliminary results of pharmacophore model matching and molecular docking suggest that AST IV and protein tyrosine phosphatase 1B (PTP1B) can be well-combined through hydrogen bonding.	Hydrogen	180-188	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	144-149
24132574-11	2013	The H2 concentration in abdominal cavity tissues, especially adipose tissue, in the FOS group was 5.6- to 43-fold of that in the control group (P &lt; 0.05).	Hydrogen	4-6	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-87
24132574-12	2013	The H2 content in the abdominal cavity in the FOS group was 11-fold of that in the control group (P &lt; 0.05).	Hydrogen	4-6	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-49
33438792-2	2021	Inspired by the interesting Z-scheme process, here we demonstrated a photocatalytic hydrogen evolution reaction (HER) employing chlorophyll derivatives, Chl-1 and Chl-2, on the surface of Ti3C2Tx MXenes with two-dimensional accordion-like morphology forming Chl-1@Chl-2@Ti3C2Tx composite.	Hydrogen	84-92	chordin like 2	Homo sapiens	163-168
24132574-17	2013	Reduced cytokine expression by FOS feeding might be dependent on increased colonic H2.	Hydrogen	83-85	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-34
24085300-7	2013	Based on the crystal structures of the p25 (p35 C-terminal region including AD)-Cdk5 complex, we simulated the three-dimensional structure of the p39 AD-Cdk5 complex and found differences in the hydrogen bond network between Cdk5 and its activators.	Hydrogen	195-203	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	39-42
33438792-2	2021	Inspired by the interesting Z-scheme process, here we demonstrated a photocatalytic hydrogen evolution reaction (HER) employing chlorophyll derivatives, Chl-1 and Chl-2, on the surface of Ti3C2Tx MXenes with two-dimensional accordion-like morphology forming Chl-1@Chl-2@Ti3C2Tx composite.	Hydrogen	84-92	chordin like 2	Homo sapiens	264-269
24085300-7	2013	Based on the crystal structures of the p25 (p35 C-terminal region including AD)-Cdk5 complex, we simulated the three-dimensional structure of the p39 AD-Cdk5 complex and found differences in the hydrogen bond network between Cdk5 and its activators.	Hydrogen	195-203	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	44-47
24085300-8	2013	Three amino acids of p35, Asp-259, Asn-266, and Ser-270, which are involved in hydrogen bond formation with Cdk5, are changed to Gln, Gln, and Pro in p39.	Hydrogen	79-87	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	21-24
33666413-2	2021	The Co-MOF/NF exhibited enhanced catalytic performance for both the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER).	Hydrogen	68-76	neurofascin	Homo sapiens	11-13
24257230-8	2013	In addition, hydrogen-rich saline also suppressed the expression of p38-mitogen-activated protein kinase (p38MAPK) and brain-derived neurotrophic factor (BDNF) in the spinal cord by 7 days post-chronic constriction injury (p&lt;0.01, p&lt;0.01, respectively), but had no effect on P2X4R (p&gt;0.05), an ATP receptor.	Hydrogen	13-21	brain-derived neurotrophic factor	Rattus norvegicus	119-152
24257230-8	2013	In addition, hydrogen-rich saline also suppressed the expression of p38-mitogen-activated protein kinase (p38MAPK) and brain-derived neurotrophic factor (BDNF) in the spinal cord by 7 days post-chronic constriction injury (p&lt;0.01, p&lt;0.01, respectively), but had no effect on P2X4R (p&gt;0.05), an ATP receptor.	Hydrogen	13-21	brain-derived neurotrophic factor	Rattus norvegicus	154-158
24257230-9	2013	CONCLUSION: Intrathecal injection of hydrogen-rich saline can decrease oxidative stress and the expression of p38MAPK and BDNF that may contribute to the elevated threshold of neuropathic pain in rat CCI model.	Hydrogen	37-45	brain-derived neurotrophic factor	Rattus norvegicus	122-126
23132527-0	2013	1H, 13C and 15N resonance assignments of the N-terminal domain of Vta1-Vps60 peptide complex.	Hydrogen	0-2	charged multivesicular body protein 5	Homo sapiens	71-76
33711010-9	2021	Differences in the morphology and dynamics of aggregates that comprise SST14 or AVP appear to reflect distinct (1) regions of the Abeta chains they interact with; (2) the propensities to engage in hydrogen bonds with Abeta peptides; and (3) solvent exposures of hydrophilic and hydrophobic groups.	Hydrogen	197-205	somatostatin	Homo sapiens	71-76
33649232-7	2021	Structural analysis, including by hydrogen-deuterium exchange coupled to mass spectrometry, revealed that the N terminus of NS2 is essential for binding to the RIG-I caspase activation and recruitment domains.	Hydrogen	34-42	DExD/H-box helicase 58	Homo sapiens	160-165
23935068-5	2013	Our model predicted previously unknown hydrogen bonding patterns involving the N-terminal domain (NTD) of RAD51.	Hydrogen	39-47	RAD51 recombinase	Homo sapiens	106-111
24001219-2	2013	A crystal structure of the hepatitis delta virus (HDV) ribozyme suggested that the pro-RP oxygen at the scissile phosphate directly coordinates a catalytic Mg(2+) ion and is within hydrogen bonding distance of the amine of the general acid C75.	Hydrogen	181-189	protein only RNase P catalytic subunit	Homo sapiens	83-89
33244883-8	2021	A molecular docking study revealed that 3 o can form stable hydrogen bonds with residues of RalA.	Hydrogen	60-68	RAS like proto-oncogene A	Homo sapiens	92-96
23790227-9	2013	A Swf1 orthologue that lacks one of the zinc-binding pockets is able to complement a yeast swf1  strain, possibly because a similar fold can be stabilized by hydrogen bonds instead of zinc co-ordination.	Hydrogen	158-166	palmitoyltransferase SWF1	Saccharomyces cerevisiae S288C	2-6
33349457-4	2021	Molecular docking predicted that fenoldopam occupied the FAD cavity of LSD1, forming hydrogen bonds with surrounding residues.	Hydrogen	85-93	lysine demethylase 1A	Homo sapiens	71-75
23790227-9	2013	A Swf1 orthologue that lacks one of the zinc-binding pockets is able to complement a yeast swf1  strain, possibly because a similar fold can be stabilized by hydrogen bonds instead of zinc co-ordination.	Hydrogen	158-166	palmitoyltransferase SWF1	Saccharomyces cerevisiae S288C	91-95
26592411-5	2013	The simulations show that acetyl-lysine has two major binding modes in TAF1(2) one of which corresponds to the available crystal structures and is stabilized by a hydrogen bond to the conserved Asn side chain.	Hydrogen	163-171	TATA-box binding protein associated factor 12	Homo sapiens	71-77
32131700-8	2021	Hydrogen bonding and/or van der Waals interactions were involved between HGD and quercetin.	Hydrogen	0-8	homogentisate 1,2-dioxygenase	Homo sapiens	73-76
32186243-8	2021	Further, the repetitive molecular dynamics simulation analysis showed that the mutant R396W demonstrated less compactness and reduced number of intramolecular hydrogen bonds compared with the mutant R396L and native GALC.	Hydrogen	159-167	galactosylceramidase	Homo sapiens	216-220
24171082-8	2013	Results : Docking studies have revealed that these types of ligands interacted mainly with II-S6 residues of NaV1.2 through making hydrogen bonds and have additional hydrophobic interactions with domain I, II, III and IV in the channel"s inner pore.	Hydrogen	131-139	sodium voltage-gated channel alpha subunit 2	Homo sapiens	109-115
33570951-0	2021	Correction to "Hydrogen-Deuterium Exchange within Adenosine Deaminase, a TIM Barrel Hydrolase, Identifies Networks for Thermal Activation of Catalysis".	Hydrogen	15-23	adenosine deaminase	Homo sapiens	50-69
23982207-5	2013	Nuclear magnetic resonance and hydrogen-deuterium exchange mass spectrometry analyses revealed that Itk and Btk had distinct protein dynamics in this region, which could explain the differences in catalytic efficiency between these kinases.	Hydrogen	31-39	Bruton tyrosine kinase	Homo sapiens	108-111
33658989-9	2020	We postulate that the Y395H variant in the IKKbeta protein lost the hydrogen bond with D389, thereby affecting interaction between Y395 and D389 and increasing protein instability.	Hydrogen	68-76	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	43-50
23950901-4	2013	SULF1 and SULF2 are highly homologous, extracellular endosulfatases, which post-synthetically edit the sulfation status of HS by removing 6OS from intact chains.	Hydrogen	123-125	sulfatase 1	Mus musculus	0-5
33300914-3	2021	Here, our approach to developing versatile ncDN hydrogels is through the use of multiple interfacial crosslinking chemistries (i.e., noncovalent interactions of electrostatic interaction and hydrogen bonds as well as dynamic covalent interactions of imine bonds and boronate ester bonds) and surface functionalized nanomaterials (i.e. phenylboronic acid modified reduced graphene oxide (PBA-rGO)).	Hydrogen	191-199	neurochondrin	Homo sapiens	43-47
23080424-9	2013	Our findings suggest that modulation of CSE/H2 S system is a potential therapeutic avenue for insulin resistance.	Hydrogen	44-46	cystathionine gamma-lyase	Homo sapiens	40-43
23776060-0	2013	Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry.	Hydrogen	103-111	MDM2 proto-oncogene	Homo sapiens	92-96
33562687-7	2021	For the fast-releasing formulation NanoCore-6.4, the AUC0 1h was significantly lower (2999.1 ng x h/mL) than the one of NanoCore-7.4 (3589.5 ng x h/mL).	Hydrogen	58-60	thrombopoietin	Mus musculus	100-102
23776060-4	2013	We present a methodology using a hydrogen/deuterium (H/D) exchange platform that measures Nutlin-3 binding to the N-terminal domain of MDM2 (MDM2(1-126)) in order to begin to develop dynamic assays that evaluate MDM2 allostery.	Hydrogen	33-41	MDM2 proto-oncogene	Homo sapiens	135-139
33399461-5	2021	The enhanced transport in plasticized PEO, as reflected by the higher SRB mobility and diffusivity, was linked to the polymer"s higher chain and segmental mobilities and reduced hydrogen-bonding interactions.	Hydrogen	178-186	chaperonin containing TCP1 subunit 4	Homo sapiens	70-73
23666867-6	2013	Considering van der Waals, electrostatic, hydrogen bond, and solvation contribution energies, the PSP is a problem with four energetic terms to be minimized.	Hydrogen	42-50	microseminoprotein beta	Homo sapiens	98-101
33440945-2	2021	Using activity-based protein profiling, we first demonstrated that BBR directly targets the NEK7 protein via the hydrogen bond between the 2,3-methylenedioxy and 121-arginine (R121) residues.	Hydrogen	113-121	NIMA related kinase 7	Homo sapiens	92-96
33372797-4	2021	The optimized VNS/NF-WM-heterostructured nanorod (volume ratio of water/methanol is 3:1) exhibits superior HER electrocatalytic activity with low overpotentials of 85 and 218 mV to yield current density values of 10 and 100 mA cm-2, respectively, meanwhile sustaining an excellent stability with almost an unchanged current density of 10 mA cm-2 for 60 h. Our work offers fresh insights into the rational design of highly active and stable earth-abundant-heterostructured electrocatalysts for the hydrogen fuel production.	Hydrogen	497-505	neurofascin	Homo sapiens	18-20
23795559-0	2013	Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study.	Hydrogen	91-99	monoglyceride lipase	Homo sapiens	64-87
23795559-3	2013	We have applied peptide-level hydrogen/deuterium exchange mass spectrometry to characterize hMGL"s conformational responses to two potent carbamylating inhibitors, AM6580 (irreversible) and AM6701 (slowly reversible).	Hydrogen	30-38	monoglyceride lipase	Homo sapiens	92-96
33415981-5	2021	Hydrogen/deuterium exchange mass spectrometry (HDX-MS) in the higher-order structure characterization of NKG2A in complex with CD94 provides novel insights into the conformational dynamics of NKG2A/CD94 heterodimer.	Hydrogen	0-8	killer cell lectin like receptor D1	Homo sapiens	127-131
23737128-2	2013	By combining the technique with DFT calculations, STM manipulation was extended to the probing of intermolecular hydrogen-bonding configurations in self-assembled nanostructures.	Hydrogen	113-121	sulfotransferase family 1A member 3	Homo sapiens	50-53
33415981-5	2021	Hydrogen/deuterium exchange mass spectrometry (HDX-MS) in the higher-order structure characterization of NKG2A in complex with CD94 provides novel insights into the conformational dynamics of NKG2A/CD94 heterodimer.	Hydrogen	0-8	killer cell lectin like receptor D1	Homo sapiens	198-202
33248643-0	2021	Nanodiamonds and hydrogen-substituted graphdiyne heteronanostructure for the sensitive impedimetric aptasensing of myocardial infarction and cardiac troponin I.	Hydrogen	17-25	troponin I3, cardiac type	Homo sapiens	141-159
33248643-1	2021	A novel heteronanostructure of nanodiamonds (NDs) and hydrogen-substituted graphdiyne (HsGDY) (denoted as HsGDY@NDs) was prepared for the impedimetric aptasensing of biomarkers such as myoglobin (Myo) and cardiac troponin I (cTnI).	Hydrogen	54-62	troponin I3, cardiac type	Homo sapiens	205-223
33248643-1	2021	A novel heteronanostructure of nanodiamonds (NDs) and hydrogen-substituted graphdiyne (HsGDY) (denoted as HsGDY@NDs) was prepared for the impedimetric aptasensing of biomarkers such as myoglobin (Myo) and cardiac troponin I (cTnI).	Hydrogen	54-62	troponin I3, cardiac type	Homo sapiens	225-229
23818638-9	2013	A PYL2-quinabactin-HAB1 X-ray crystal structure solved at 1.98-A resolution shows that quinabactin forms a hydrogen bond with the receptor/PP2C "lock" hydrogen bond network, a structural feature absent in pyrabactin-receptor/PP2C complexes.	Hydrogen	107-115	HAB1	Homo sapiens	19-23
23818638-9	2013	A PYL2-quinabactin-HAB1 X-ray crystal structure solved at 1.98-A resolution shows that quinabactin forms a hydrogen bond with the receptor/PP2C "lock" hydrogen bond network, a structural feature absent in pyrabactin-receptor/PP2C complexes.	Hydrogen	151-159	HAB1	Homo sapiens	19-23
32268871-9	2021	Molecular docking study demonstrated that four more hydrogen bonds were established between IKKbeta and compound 4, compared with GA.	Hydrogen	52-60	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	92-99
23687377-4	2013	On the basis of the crystal structure of the Cx26 gap junction, we developed homology models for homotypic and heterotypic channels from Cx32 and/or Cx26; these models predict six hydrogen bonds at the docking interface of each pair of the second extracellular domain (E2).	Hydrogen	180-188	gap junction protein beta 1	Homo sapiens	137-141
23687377-5	2013	A Cx32 mutation N175H and a human-disease-linked mutant N175D were predicted to lose the majority of the hydrogen bonds at the E2 docking-interface; experimentally both mutations failed to form morphological and functional gap junctions.	Hydrogen	105-113	gap junction protein beta 1	Homo sapiens	2-6
23687377-8	2013	By testing more homotypic and heterotypic Cx32 and/or Cx26 mutant combinations, it is revealed that a minimum of four hydrogen bonds at each E2-docking interface are required for proper docking and functional channel formation between Cx26 and Cx32 hemichannels.	Hydrogen	118-126	gap junction protein beta 1	Homo sapiens	42-46
23687377-8	2013	By testing more homotypic and heterotypic Cx32 and/or Cx26 mutant combinations, it is revealed that a minimum of four hydrogen bonds at each E2-docking interface are required for proper docking and functional channel formation between Cx26 and Cx32 hemichannels.	Hydrogen	118-126	gap junction protein beta 1	Homo sapiens	244-248
23689510-6	2013	A crystal structure of Gipg013 Fab in complex with the human GIPr extracellular domain (ECD) shows that the antibody binds through a series of hydrogen bonds from the complementarity-determining regions of Gipg013 Fab to the N-terminal alpha-helix of GIPr ECD as well as to residues around its highly conserved glucagon receptor subfamily recognition fold.	Hydrogen	143-151	ecdysoneless cell cycle regulator	Homo sapiens	88-91
23297114-5	2013	In endothelial cells, H2 S treatment reduces the increase in MCP-1, inter-cellular adhesion molecule-1, vascular cell adhesion molecule-1, and of a disintegrin and metalloproteinase metallopeptidase domain 17 (ADAM17), both at the gene expression and protein levels.	Hydrogen	22-24	ADAM metallopeptidase domain 17	Homo sapiens	210-216
23652817-3	2013	Using suitable proxies arranged in pseudo-crystalline setups we discriminate the contribution of hydrogen bonding, pi-pi interactions and intra-molecular interactions to the lattice energies of the most relevant (P1 and P3) benzamide polymorphs.	Hydrogen	97-105	crystallin gamma F, pseudogene	Homo sapiens	213-222
23675760-1	2013	Sorbent-enhanced steam methane reforming (SE-SMR) is an emerging technology for the production of high-purity hydrogen from hydrocarbons with in situ CO2 capture.	Hydrogen	110-118	LY6/PLAUR domain containing 4	Homo sapiens	45-48
23377959-3	2013	The high antioxidant activity of both 3, 3"-DM-4, 4"-DHS and 3, 4-DHS may be due to the abstraction of the two hydrogen atoms of the para and ortho-position hydroxyls respectively, to form a quinone structure.	Hydrogen	111-119	DHS	Homo sapiens	53-56
23377959-3	2013	The high antioxidant activity of both 3, 3"-DM-4, 4"-DHS and 3, 4-DHS may be due to the abstraction of the two hydrogen atoms of the para and ortho-position hydroxyls respectively, to form a quinone structure.	Hydrogen	111-119	DHS	Homo sapiens	66-69
23545808-2	2013	The aim of the present study was to investigate the direct effects of acid loading on the proliferation of rat glomerular mesangial cells (GMCs) in vitro and the possible role of sodium-hydrogen ion exchanger isoform 1 (NHE1).	Hydrogen	186-194	solute carrier family 9 member A1	Rattus norvegicus	220-224
23738009-7	2013	In the E-&gt;G mutants, however, the tri-phosphate moiety is found reorganized to the same tightly bound structure through a unique set of hydrogen bonds with Fic signature motif residues.	Hydrogen	139-147	C-C motif chemokine ligand 7	Homo sapiens	159-162
23609816-1	2013	This work describes a highly active and stable acid activated carbon fibre and amorphous MoS(x) composite hydrogen evolution catalyst.	Hydrogen	106-114	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	89-92
23485707-1	2013	Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio.	Hydrogen	113-117	aquaporin 4	Homo sapiens	46-50
23480575-3	2013	Quantum mechanical calculations using density function theory (DFT) indicate a modest decrease in bond dissociation enthalpy, BDE, for (weakest) hydrogen-oxygen phenolic bond in daidzein from 368.4 kJ   mol(- 1) to 367.7 kJ   mol(- 1) compared to a significant increase in quercetin from 329.5 kJ   mol(- 1) to 356.6 kJ   mol(- 1) upon derivatization.	Hydrogen	145-153	homeobox D13	Homo sapiens	126-129
23363739-6	2013	The third Glcbeta residues of NeuSLac and NeuSCel were also predicted to be stabilized by hydrogen bonds with the side chains of the R21, R304, D358 and Y359 residues of NEU2.	Hydrogen	90-98	neuraminidase 2	Homo sapiens	170-174
23532540-6	2013	Our results indicate that inhibitors of PEPCK with their short chains interact with enzyme active site through non-covalent interactions of electrostatic and hydrogen bond nature.	Hydrogen	158-166	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	40-45
23320793-3	2013	Using hydrogen adsorption as a testing example, we further demonstrate that the introduction of a metal substrate can substantially alter the chemical reactivity of the adsorbed MoS(2) layer.	Hydrogen	6-14	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	178-181
23320793-4	2013	The enhanced binding of hydrogen, by as much as ~0.4 eV, is attributed in part to a stronger H-S coupling enabled by the transferred charge from the substrate to the MoS(2) overlayer, and in part to a stronger MoS(2)-metal interface by the hydrogen adsorption.	Hydrogen	24-32	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	166-169
23320793-4	2013	The enhanced binding of hydrogen, by as much as ~0.4 eV, is attributed in part to a stronger H-S coupling enabled by the transferred charge from the substrate to the MoS(2) overlayer, and in part to a stronger MoS(2)-metal interface by the hydrogen adsorption.	Hydrogen	24-32	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	210-213
23320793-4	2013	The enhanced binding of hydrogen, by as much as ~0.4 eV, is attributed in part to a stronger H-S coupling enabled by the transferred charge from the substrate to the MoS(2) overlayer, and in part to a stronger MoS(2)-metal interface by the hydrogen adsorption.	Hydrogen	240-248	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	166-169
23320793-4	2013	The enhanced binding of hydrogen, by as much as ~0.4 eV, is attributed in part to a stronger H-S coupling enabled by the transferred charge from the substrate to the MoS(2) overlayer, and in part to a stronger MoS(2)-metal interface by the hydrogen adsorption.	Hydrogen	240-248	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	210-213
23060076-0	2013	Highly efficient electrocatalytic hydrogen production by MoS(x) grown on graphene-protected 3D Ni foams.	Hydrogen	34-42	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	57-60
23060076-1	2013	A three-dimensional Ni foam deposited with graphene layers on surfaces is used as a conducting solid support to load MoS(x) catalysts for electrocatalytic hydrogen evolution.	Hydrogen	155-163	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	117-120
23290725-4	2013	Here, insights into the structural mechanism of proteins in the ABA signaling pathway (the ABA receptor PYL2, HAB1 phosphatase, and two kinases, SnRK2.3 and 2.6) are discerned through hydrogen/deuterium exchange (HDX) mass spectrometry.	Hydrogen	184-192	HAB1	Homo sapiens	110-114
23266184-3	2013	X-ray analysis of the VDR with compound 6 revealed all of the six fluorine atoms of the hexafluoropropanol (HFP) moiety in the side chain effectively interacting with the VDR by both steric (van der Waals) and electrostatic (hydrogen bond, NH-F and CH-F) interactions.	Hydrogen	225-233	vitamin D receptor	Homo sapiens	22-25
23266184-3	2013	X-ray analysis of the VDR with compound 6 revealed all of the six fluorine atoms of the hexafluoropropanol (HFP) moiety in the side chain effectively interacting with the VDR by both steric (van der Waals) and electrostatic (hydrogen bond, NH-F and CH-F) interactions.	Hydrogen	225-233	vitamin D receptor	Homo sapiens	171-174
23229515-4	2013	We demonstrate that CLOCK and BMAL1 bHLH domains can be mutually selected, and that hydrogen-bonding networks mediate their E-box recognition.	Hydrogen	84-92	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	30-35
23313634-4	2013	Overall, these studies showed that the combined presence of a phenyl group at C-3 and a methyl group at C-5 in the 1H,3H-pyrrolo[1,2-c]thiazole ring system is essential to ensure high cytotoxicty against MCF7 breast cancer cell lines.	Hydrogen	115-117	complement C3	Homo sapiens	78-81
23273744-8	2013	Furthermore, hydrogen decreased the apoptotic index of the cells and inhibited the protein expression of intercellular adhesion molecule-1 and caspase-3 in lung grafts from brain-dead donors.	Hydrogen	13-21	intercellular adhesion molecule 1	Homo sapiens	105-138
23334436-3	2013	The best HypoGen pharmacophore model for ACC2 inhibitors (Hypo1_ACC2) consists of one hydrogen bond acceptor, one hydrophobic aliphatic and one hydrophobic aromatic feature, whereas the best pharmacophore (Hypo1_ACC1) for ACC1 consists of one additional hydrogen-bond donor (HBD) features.	Hydrogen	254-262	acetyl-CoA carboxylase alpha	Homo sapiens	212-216
23334436-3	2013	The best HypoGen pharmacophore model for ACC2 inhibitors (Hypo1_ACC2) consists of one hydrogen bond acceptor, one hydrophobic aliphatic and one hydrophobic aromatic feature, whereas the best pharmacophore (Hypo1_ACC1) for ACC1 consists of one additional hydrogen-bond donor (HBD) features.	Hydrogen	254-262	acetyl-CoA carboxylase alpha	Homo sapiens	222-226
23149626-0	2013	The influence of carbon content on the structure and properties of MoS(x)C(y) photocatalysts for light-driven hydrogen generation.	Hydrogen	110-118	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	67-70
22996636-1	2013	Calorimetry is used to measure the reaction enthalpies of hydrogen (H(2)) activation by 2,6-lutidine (Lut), 2,2,6,6-tetramethylpiperidine (TMP), N-methyl-2,2,6,6-tetramethylpiperidine (MeTMP), and tri-tert-butylphosphine (TBP) with tris(pentafluorophenyl)borane (BCF).	Hydrogen	58-66	TATA-box binding protein	Homo sapiens	222-225
22996636-1	2013	Calorimetry is used to measure the reaction enthalpies of hydrogen (H(2)) activation by 2,6-lutidine (Lut), 2,2,6,6-tetramethylpiperidine (TMP), N-methyl-2,2,6,6-tetramethylpiperidine (MeTMP), and tri-tert-butylphosphine (TBP) with tris(pentafluorophenyl)borane (BCF).	Hydrogen	68-72	TATA-box binding protein	Homo sapiens	222-225
23194158-0	2013	Hot electrons do the impossible: plasmon-induced dissociation of H2 on Au.	Hydrogen	65-67	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
23286827-12	2013	Mutational analysis of DAOA revealed significant effects on hydrogen bonding and correct folding of the DAOA protein, which in turn affect protein conformation.	Hydrogen	60-68	D-amino acid oxidase activator	Homo sapiens	23-27
23286827-12	2013	Mutational analysis of DAOA revealed significant effects on hydrogen bonding and correct folding of the DAOA protein, which in turn affect protein conformation.	Hydrogen	60-68	D-amino acid oxidase activator	Homo sapiens	104-108
23286827-18	2013	Protein-protein docking simulation demonstrated two ionic bonds and one hydrogen bond involving DAOA.	Hydrogen	72-80	D-amino acid oxidase activator	Homo sapiens	96-100
23983797-6	2013	The expression of mRNA of tumor necrosis factor- alpha (TNF- alpha ) and intercellular adhesion molecule-1 (ICAM-1) in the pancreas was reduced in hydrogen-rich saline treated group.	Hydrogen	147-155	intercellular adhesion molecule 1	Rattus norvegicus	73-106
23983797-6	2013	The expression of mRNA of tumor necrosis factor- alpha (TNF- alpha ) and intercellular adhesion molecule-1 (ICAM-1) in the pancreas was reduced in hydrogen-rich saline treated group.	Hydrogen	147-155	intercellular adhesion molecule 1	Rattus norvegicus	108-114
23153179-11	2013	In addition, salt bridging and hydrogen bond contacts between ligands (14, 25, and 37) and CCR5 are also crucial for inhibitory activity.	Hydrogen	31-39	C-C motif chemokine receptor 5	Homo sapiens	91-95
23212446-9	2013	Treatment with H(2) inhibited TNFalpha-induced IL-6 and ICAM-1 mRNA expression.	Hydrogen	15-19	intercellular adhesion molecule 1	Rattus norvegicus	56-62
24257095-4	2013	A 77-residue human inflammatory protein (complement C3a) important in innate immunity is rationally transformed to equipotent small molecules, using peptide surrogates that incorporate a turn-inducing heterocycle with correctly positioned hydrogen-bond-accepting atoms.	Hydrogen	239-247	complement C3	Homo sapiens	52-55
22827513-1	2013	Radical cationic repair process of cis-syn thymine dimer has been investigated when (1) sugar-phosphate backbones were substituted by hydrogen atoms, (2) phosphate group was substituted by two hydrogen atoms each on a sugar ring and (3) sugar-phosphate backbone was taken into account.	Hydrogen	134-142	synemin	Homo sapiens	39-42
22827513-1	2013	Radical cationic repair process of cis-syn thymine dimer has been investigated when (1) sugar-phosphate backbones were substituted by hydrogen atoms, (2) phosphate group was substituted by two hydrogen atoms each on a sugar ring and (3) sugar-phosphate backbone was taken into account.	Hydrogen	193-201	synemin	Homo sapiens	39-42
23987088-2	2013	A five-point pharmacophore with two hydrogen bond acceptors, one hydrogen bond donor and two aromatic ring features was generated for a series of benzofuran salicylic acid derivatives as LYP inhibitors in order to elucidate their anti-autoimmune activity.	Hydrogen	36-44	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	187-190
23176629-5	2012	The extensive electrostatic/hydrogen binding network that includes heme propionate groups, Lys67, His64, and Tyr44 not only restricts the heme binding but also modulates the energetics of binding of CO to the five-coordinate hNgb as substitution of His64 with Gln leads to an endothermic association of CO with the five-coordinate hNgb (DeltaH = 6 +- 3 kcal mol(-1)).	Hydrogen	28-36	neuroglobin	Homo sapiens	225-229
23176629-5	2012	The extensive electrostatic/hydrogen binding network that includes heme propionate groups, Lys67, His64, and Tyr44 not only restricts the heme binding but also modulates the energetics of binding of CO to the five-coordinate hNgb as substitution of His64 with Gln leads to an endothermic association of CO with the five-coordinate hNgb (DeltaH = 6 +- 3 kcal mol(-1)).	Hydrogen	28-36	neuroglobin	Homo sapiens	331-335
23249007-1	2012	Rearrangement of intermolecular hydrogen bond in a monohydrated tryptamine cation, [TRA(H(2)O)(1)](+), has been investigated in the gas phase by IR spectroscopy and quantum chemical calculations.	Hydrogen	32-40	T cell receptor alpha locus	Homo sapiens	84-87
23249007-2	2012	In the S(0) state of TRA(H(2)O)(1), a water molecule is hydrogen-bonded to the N atom of the amino group of a flexible ethylamine side chain [T. S. Zwier, J. Phys.	Hydrogen	56-64	T cell receptor alpha locus	Homo sapiens	21-24
23249007-5	2012	A remarkable change in the hydrogen-bonding motif of [TRA(H(2)O)](+) occurs upon photoionization.	Hydrogen	27-35	T cell receptor alpha locus	Homo sapiens	54-57
23249007-6	2012	In the D(0) state of [TRA(H(2)O)(1)](+), the water molecule is hydrogen-bonded to the NH group of the indole ring of TRA(+), indicating that the water molecule transfers from the amino group to NH group.	Hydrogen	63-71	T cell receptor alpha locus	Homo sapiens	22-25
23249007-6	2012	In the D(0) state of [TRA(H(2)O)(1)](+), the water molecule is hydrogen-bonded to the NH group of the indole ring of TRA(+), indicating that the water molecule transfers from the amino group to NH group.	Hydrogen	63-71	T cell receptor alpha locus	Homo sapiens	117-120
22960610-6	2012	Exposure of myotubes to ischemic insult in the presence of betaNGF, added either 1h before oxygen-glucose-deprivation or concomitant with reoxygenation insults, resulted with about 20% and 33% myoprotection, an effect antagonized by VLO5 and Thx-B, further supporting the trophic role of NGF in C2C12 cells.	Hydrogen	81-83	nerve growth factor	Mus musculus	63-66
23046248-3	2012	The nanomolar inhibitor 5 possessed good p53-MDM2 inhibitory activity (K(i) = 780 nM) due to its hydrophobic and hydrogen bonding interactions with MDM2.	Hydrogen	113-121	MDM2 proto-oncogene	Homo sapiens	45-49
23046248-3	2012	The nanomolar inhibitor 5 possessed good p53-MDM2 inhibitory activity (K(i) = 780 nM) due to its hydrophobic and hydrogen bonding interactions with MDM2.	Hydrogen	113-121	MDM2 proto-oncogene	Homo sapiens	148-152
22992513-7	2012	We show that MED25-BINDING RING-H2 PROTEIN1 (MBR1) and MBR2 bind to PFT1 in yeast (Saccharomyces cerevisiae) and in vitro, and they promote PFT1 degradation in vivo, in a RING-H2-dependent way, typical of E3 ubiquitin ligases.	Hydrogen	32-34	RING/U-box superfamily protein	Arabidopsis thaliana	45-49
22902581-5	2012	The weak (NC)-H O hydrogen bond type interaction (H O distance: 252.2 pm) in form E-AG, together with the absence in this form of the destabilizing interaction between the lone electron pairs of the oxygen and nitrogen atoms existing in E-SG, explains its lower energy in comparison with this latter form.	Hydrogen	18-26	potassium voltage-gated channel subfamily H member 1	Homo sapiens	82-86
22521290-7	2012	KEY FINDINGS: Constrictor responses to phenylephrine (PE) and ET-1 were increased in vessels treated for 1h with chemerin.	Hydrogen	105-107	retinoic acid receptor responder 2	Rattus norvegicus	113-121
33045547-5	2021	The results showed that HBD hydrophilic ability, HBD polarity, HBD acidity, HBD ability to form hydrogen bonds, molar ratio of HBD to choline chloride and pretreatment severity had great influence on the Choline chloride based deep eutectic solvents pretreatment effect.	Hydrogen	96-104	HBD	Homo sapiens	24-27
33645072-19	2021	The results of molecular docking showed that limonin, palmatine and berberine could bind to CASP3 and MMP9 by hydrogen bond.	Hydrogen	110-118	caspase 3	Mus musculus	92-97
33327463-4	2020	The N-terminal short helices, alpha1 and alpha2, constitute a meander region, and form hydrogen bonds with residues 3-5 in the N-terminal loop, which are not present in the GSs of other species.	Hydrogen	87-95	anon-A1	Drosophila melanogaster	30-47
32779575-0	2020	Analysis of Binding Mode of 2"-GMP to Proteins Using 1H/31P NMR Spectroscopy.	Hydrogen	53-55	5'-nucleotidase, cytosolic II	Homo sapiens	31-34
33321754-0	2020	1H NMR Spin-Lattice Relaxometry of Cement Pastes with Polycarboxylate Superplasticizers.	Hydrogen	0-2	spindlin 1	Homo sapiens	7-11
33321754-1	2020	1H spin-lattice relaxometry (T1, longitudinal) of cement pastes with 0 to 0.18 wt % polycarboxylate superplasticizers (PCEs) at intervals of 0.06 wt % from 10 min to 1210 min was investigated.	Hydrogen	0-2	spindlin 1	Homo sapiens	3-7
32853467-2	2020	The release of   CF3 radical occurred from temperature above 85  C. Deeper 1H and 19F nuclear magnetic resonance spectroscopies of the resulting fluorinated polystyrenes (CF3-PSts) evidenced the presence of both CF3 end-group of the PSt chain and the trifluoromethylation of the phenyl ring (in meta position mainly).	Hydrogen	75-77	kallikrein related peptidase 4	Homo sapiens	175-179
33273142-4	2020	This structure confirms the high structural flexibility of Gly-Aib peptides and points to a strong relationship between intermolecular hydrogen bonding and crystal quality and size.	Hydrogen	135-143	ANIB1	Homo sapiens	63-66
23047487-8	2012	Our data confirmed the inhibitory effect of HS on bovine serum albumin, serum glycosylated protein, glycation of LDL, and glycation hemoglobin.	Hydrogen	44-46	albumin	Rattus norvegicus	57-70
32622167-5	2020	For instance, the high Pd/cells (over 0.18 pg cell-1) exhibited almost 6-fold and 1.5-fold enhancement over EAB-Pds with Pd/cells below 0.03 in catalytic current toward hydrogen evolution reaction and nitrobenzene reduction, respectively.	Hydrogen	169-177	carboxyl ester lipase pseudogene	Homo sapiens	46-52
23125802-2	2012	The N-H group attached to the exocyclic C=C bond is in a syn arrangement with respect to the C=O bond of the pyrazolone group and an intra-molecular N-H O hydrogen bond is observed.	Hydrogen	155-163	synemin	Homo sapiens	57-60
32768811-6	2020	The sensitivity of the resulted qy-RDX is much better than pristine RDX due to improved crystal quality as well as higher concentration of hydrogen bonds.	Hydrogen	139-147	radixin	Homo sapiens	35-38
22609825-2	2012	After 1h home cage deprivation we observed an increase in the number of c-Fos (neuronal activity marker) immunoreactive cells in several brain regions of the olfactory and stress-related areas in normal neonates at 11 days.	Hydrogen	6-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	72-77
33086047-1	2020	Amide hydrogen-deuterium exchange mass spectrometry is powerful for describing combinatorial coupling effects of a cooperative ligand pair binding at noncontiguous sites: adenosine at the ATP-pocket and a docking peptide (PIFtide) at the PIF-pocket, on a model protein kinase PDK1.	Hydrogen	6-14	pyruvate dehydrogenase kinase 1	Homo sapiens	276-280
23383496-8	2012	For example, in the separation of purines, pyrimidines and pterins on MSP, hydrogen-bonding and dipole-dipole interactions played leading roles besides hydrophobic interaction.	Hydrogen	75-83	microseminoprotein beta	Homo sapiens	70-73
32916221-8	2020	Notably, the protection of XQ-1H was abolished by Wnt/GSK3beta/beta-catenin inhibitor XAV939 or beta-catenin siRNA, indicating XQ-1H exerted protection in a Wnt/GSK3beta/beta-catenin dependent profile.	Hydrogen	30-32	catenin (cadherin associated protein), beta 1	Mus musculus	63-75
32916221-8	2020	Notably, the protection of XQ-1H was abolished by Wnt/GSK3beta/beta-catenin inhibitor XAV939 or beta-catenin siRNA, indicating XQ-1H exerted protection in a Wnt/GSK3beta/beta-catenin dependent profile.	Hydrogen	30-32	catenin (cadherin associated protein), beta 1	Mus musculus	96-108
22940950-1	2012	We have developed a high-spectral-resolution laser system for two-photon pump, polarization spectroscopy probe (TPP-PSP) measurements of atomic hydrogen in flames.	Hydrogen	144-152	microseminoprotein beta	Homo sapiens	116-119
32916221-8	2020	Notably, the protection of XQ-1H was abolished by Wnt/GSK3beta/beta-catenin inhibitor XAV939 or beta-catenin siRNA, indicating XQ-1H exerted protection in a Wnt/GSK3beta/beta-catenin dependent profile.	Hydrogen	30-32	catenin (cadherin associated protein), beta 1	Mus musculus	96-108
32994821-0	2020	Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer.	Hydrogen	0-8	CD8a molecule	Homo sapiens	57-60
32994821-0	2020	Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer.	Hydrogen	0-8	CD8a molecule	Homo sapiens	101-104
32994821-1	2020	As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells, possibly by activating mitochondria.	Hydrogen	24-32	CD8a molecule	Homo sapiens	107-110
32994821-1	2020	As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells, possibly by activating mitochondria.	Hydrogen	24-32	CD8a molecule	Homo sapiens	132-135
33126626-2	2020	Through the detailed study of graphene growth on liquid Sn using atmospheric pressure CVD (APCVD), the quality of graphene has been found to have a close relationship with hydrogen flow rate that reflects on hydrogen partial pressure inside the reactor (PH2) and hydrogen solubility of the growth substrates.	Hydrogen	172-180	polyhomeotic homolog 2	Homo sapiens	254-257
33126626-2	2020	Through the detailed study of graphene growth on liquid Sn using atmospheric pressure CVD (APCVD), the quality of graphene has been found to have a close relationship with hydrogen flow rate that reflects on hydrogen partial pressure inside the reactor (PH2) and hydrogen solubility of the growth substrates.	Hydrogen	208-216	polyhomeotic homolog 2	Homo sapiens	254-257
33126626-2	2020	Through the detailed study of graphene growth on liquid Sn using atmospheric pressure CVD (APCVD), the quality of graphene has been found to have a close relationship with hydrogen flow rate that reflects on hydrogen partial pressure inside the reactor (PH2) and hydrogen solubility of the growth substrates.	Hydrogen	208-216	polyhomeotic homolog 2	Homo sapiens	254-257
32328881-0	2020	1H, 13C, 15N resonance assignments and secondary structure of yeast oligosaccharyltransferase subunit Ost4 and its functionally important mutant Ost4V23D.	Hydrogen	0-2	olichyl-diphosphooligosaccharide--protein glycotransferase OST4	Saccharomyces cerevisiae S288C	102-106
32328881-13	2020	Here, we report the backbone 1H, 13C, and 15N resonance assignments for Ost4 and Ost4V23D in dodecylphosphocholine micelles.	Hydrogen	29-31	olichyl-diphosphooligosaccharide--protein glycotransferase OST4	Saccharomyces cerevisiae S288C	72-76
32464200-5	2020	Circular dichroism and molecular docking suggested that anthraquinones could not chelate directly the copper ions but they could bind to amino acid residues in the active site of tyrosinase via electrostatic forces and hydrophobic interactions, as well as hydrogen bonds, and the binding processes resulted in the conformational changes of tyrosinase and prevented the substrate (L-DOPA) from entering the active site, which led to the decrease of tyrosinase activity.	Hydrogen	256-264	tyrosinase	Homo sapiens	179-189
32998442-8	2020	The crystal structure of the BBM-TTR complex shows two molecules binding deeply in the thyroxine binding channel, forming strong intermonomer hydrogen bonds and increasing the stability of the TTR tetramer.	Hydrogen	142-150	transthyretin	Homo sapiens	33-36
32998442-8	2020	The crystal structure of the BBM-TTR complex shows two molecules binding deeply in the thyroxine binding channel, forming strong intermonomer hydrogen bonds and increasing the stability of the TTR tetramer.	Hydrogen	142-150	transthyretin	Homo sapiens	193-196
32974652-3	2020	In this work, we present structural insights for the recognition of DR5 and DR0 elements by RXR-RAR heterodimer using x-ray crystallography, small angle x-ray scattering, and hydrogen/deuterium exchange coupled to mass spectrometry.	Hydrogen	175-183	retinoid X receptor alpha	Homo sapiens	92-95
32738139-4	2020	Furthermore, the modelling suggests that TSHbeta and TSHbetav proteins clasped the concave surface of the leucine rich region of the TSHR ECD in a similar way to the native TSH using dynamic hydrogen bonding.	Hydrogen	191-199	thyroid stimulating hormone receptor	Homo sapiens	133-137
32229254-3	2020	By protocol, oxytocin use and/or artificial rupture of the membranes was restricted to cases without progress in cervical dilatation for >= 1h and/or no progress of fetal descent for >= 1h at full dilatation.	Hydrogen	140-142	oxytocin/neurophysin I prepropeptide	Homo sapiens	13-21
32229254-3	2020	By protocol, oxytocin use and/or artificial rupture of the membranes was restricted to cases without progress in cervical dilatation for >= 1h and/or no progress of fetal descent for >= 1h at full dilatation.	Hydrogen	186-188	oxytocin/neurophysin I prepropeptide	Homo sapiens	13-21
32804466-0	2020	Hydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a Rat Hemorrhagic Shock Model.	Hydrogen	0-8	gastrin	Rattus norvegicus	9-12
32804466-1	2020	BACKGROUND: Hydrogen gas (H2) inhalation during hemorrhage stabilizes post-resuscitation hemodynamics, improving short-term survival in a rat hemorrhagic shock and resuscitation (HS/R) model.	Hydrogen	12-20	gastrin	Rattus norvegicus	21-24
32787001-0	2020	Vibrational Raman Shifts of Spin Isomer Combinations of Hydrogen Dimers and Isotopologues.	Hydrogen	56-64	spindlin 1	Homo sapiens	28-32
32422489-9	2020	Molecular docking studies also shown that compound 12k capably intermingled with catalytically active residues GLU-885, ASP-1046 of the VEGFR-2 through hydrogen-bonding interactions.	Hydrogen	152-160	kinase insert domain receptor	Homo sapiens	136-143
32454156-7	2020	Our MD model proposed that two TFF3 monomers form hydrogen bonds with the region b" of PDIA1 through two stepwise reactions.	Hydrogen	50-58	trefoil factor 3	Rattus norvegicus	31-35
32661543-0	2020	Spin controlled surface chemistry: alkyl desorption from Si(100)-2x1 by nonadiabatic hydrogen elimination.	Hydrogen	85-93	spindlin 1	Homo sapiens	0-4
32618986-6	2020	In addition, the CHO hydrogen bond in the syn(CO)-VCI further stabilizes the S1-state intermediates and makes them less reactive; in contrast, isomerization to dioxirane becomes the globally dominant channel in the anti(CO)-VCI.	Hydrogen	21-29	synemin	Homo sapiens	42-45
22859731-6	2012	With hydrogen as the electron donor, strain B10(T) produced methane by reducing methanol.	Hydrogen	5-13	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	44-47
32501695-3	2020	1H-15N NMR spin relaxation experiments can reveal the extent of protein motions across the ps-ns dynamics probed by the fundamental parameters 15N-R1, 15N-R2 and 1H-15N NOE that can be well sampled by molecular dynamics simulations (MD).	Hydrogen	0-2	spindlin 1	Homo sapiens	11-15
32501695-3	2020	1H-15N NMR spin relaxation experiments can reveal the extent of protein motions across the ps-ns dynamics probed by the fundamental parameters 15N-R1, 15N-R2 and 1H-15N NOE that can be well sampled by molecular dynamics simulations (MD).	Hydrogen	162-164	spindlin 1	Homo sapiens	11-15
22644137-2	2012	The as-prepared porous spheres, with a pore-size of around 7 nm and a large specific surface area of 132 m(2) g(-1), show superior photocatalytic hydrogen production activity over P25 and commercial-Ta(2)O(5).	Hydrogen	146-154	tubulin polymerization promoting protein	Homo sapiens	180-183
32424388-3	2020	As an example, the crystal structure of the kinase inhibitor dasatinib bound to the Abl1 kinase shows a hydrogen bond between the drug and residue Thr315 and very few contacts between the drug and residues Val299 and Phe317, yet mutations in those residues lead to drug resistance.	Hydrogen	104-112	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	84-88
33209248-12	2020	A strong spin-cooperation between the two iron centres also reduces the barrier for second hydrogen atom abstraction, thus making the desaturation pathway competitive.	Hydrogen	91-99	spindlin 1	Homo sapiens	9-13
32420732-0	2020	The Impact of Glycosylation on the Comparability of the Higher Order Structures in Idursulfase by Hydrogen-Deuterium Exchange Mass Spectrometry.	Hydrogen	98-106	iduronate 2-sulfatase	Homo sapiens	83-94
32420732-1	2020	Characterization of the higher order structures in Idursulfase (iduronate-2-sulfatase, I2S) has been accomplished through the use of hydrogen-deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	133-141	iduronate 2-sulfatase	Homo sapiens	51-62
32420732-1	2020	Characterization of the higher order structures in Idursulfase (iduronate-2-sulfatase, I2S) has been accomplished through the use of hydrogen-deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	133-141	iduronate 2-sulfatase	Homo sapiens	64-85
32462154-1	2020	The stepwise solvation of various cationic coronene oligomers by para-hydrogen (p-H2) molecules was computationally investigated using a united-atom model for the p-H2 molecules and the Silvera-Goldman potential, together with a polarizable description for the interaction with the hydrocarbon molecules.	Hydrogen	70-78	polyhomeotic homolog 2	Homo sapiens	80-84
32566932-6	2020	Composite membranes of PBI and phosphates, particularly in situ formed phosphosilicates in the polymer matrix, showed exceptionally stable conductivity at temperatures well above 200 C. Fuel cell tests at up to 260 C are reported operational with good tolerance of up to 16% CO in hydrogen, fast kinetics for direct methanol oxidation, and feasibility of nonprecious metal catalysts.	Hydrogen	281-289	submaxillary gland androgen regulated protein 3A	Homo sapiens	23-26
32379975-5	2020	Strong interactions were observed between the chlorine anions and some of the hydrogen atoms of the refrigerants, but in general the cation-refrigerant and HBD-refrigerant interactions are weaker compared to the refrigerant-refrigerant interactions.	Hydrogen	78-86	HBD	Homo sapiens	156-159
31782895-5	2020	Y-1-H and EMSA studies confirmed the binding of MYC2 with the 5" UTR region of P5CS1.	Hydrogen	2-5	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	79-84
32469979-3	2020	The goal of the current study was to investigate the role of sodium-hydrogen exchanger type 1 (NHE1) in blood brain barrier (BBB) integrity during CSD events and the contributions of this antiporter on xenobiotic uptake.	Hydrogen	68-76	solute carrier family 9 member A1	Rattus norvegicus	95-99
32141714-6	2020	Even at -20  C, there is still over 600 mL/g H 2 released at a conversion rate of 70.7% within 100 min for methanolysis, rendering it a prominent advantage for hydrogen production, especially in winter or subzero areas.	Hydrogen	160-168	growth hormone 2	Homo sapiens	43-48
32401422-2	2020	This chloride-chloride ion-pair cluster consists of a [Cl2 (H2 O)2 ]2- square with opposite edges bridged by water molecules to give a chair-like structure of the non-hydrogen atoms.	Hydrogen	167-175	endogenous retrovirus group W member 5	Homo sapiens	55-58
32451094-6	2020	Furthermore, docking simulations indicated that two chalcones (isobavachalcone and bavachalcone) could interact with the key residues located in the catalytic cavity of PL via hydrogen binding and hydrophobic interactions.	Hydrogen	176-184	pancreatic lipase	Homo sapiens	169-171
32040235-0	2020	Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway.	Hydrogen	0-8	Kelch-like ECH-associated protein 1	Rattus norvegicus	77-82
31984539-6	2020	Specifically, DATS treatment significantly upregulated the expression and enzymatic activity of cystathionine gamma-lyase (CTH), one of H2 S-producing enzymes, which was responsible for endogenous H2 S generation.	Hydrogen	136-138	cystathionine gamma-lyase	Homo sapiens	96-121
31984539-6	2020	Specifically, DATS treatment significantly upregulated the expression and enzymatic activity of cystathionine gamma-lyase (CTH), one of H2 S-producing enzymes, which was responsible for endogenous H2 S generation.	Hydrogen	136-138	cystathionine gamma-lyase	Homo sapiens	123-126
31984539-9	2020	These evidences proved that exogenous H2 S elevated CTH expression.	Hydrogen	38-40	cystathionine gamma-lyase	Homo sapiens	52-55
31984539-10	2020	CTH, in turn, catalytically generated a much higher level of endogenous H2 S. This positive feedback sustained excess H2 S production, which resulted in PTC cells growth inhibition.	Hydrogen	72-74	cystathionine gamma-lyase	Homo sapiens	0-3
31984539-10	2020	CTH, in turn, catalytically generated a much higher level of endogenous H2 S. This positive feedback sustained excess H2 S production, which resulted in PTC cells growth inhibition.	Hydrogen	118-120	cystathionine gamma-lyase	Homo sapiens	0-3
32496146-10	2020	The hydrogen-bonding interaction of T3 with TRalpha at His-381 was also shared by majority of analogs.	Hydrogen	4-12	T cell receptor alpha locus	Homo sapiens	44-51
32431933-5	2020	Similar dimers are formed in 1-(4-azido-phen-yl)-3-[3-methyl-5-(naphthalen-2-yl-oxy)-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one, C29H21N5O2, (IIe), but here the dimers are linked into a chain of rings by two independent C-H..pi(arene) hydrogen bonds.	Hydrogen	233-241	engrailed homeobox 1	Homo sapiens	117-121
32045054-7	2020	Molecular docking of the designed compounds in the VEGFR-2 and FGFR-1 active sites showed the accommodation of the 2-phenylbenzothiazole moiety, as reported, in the hinge region of the receptor tyrosine kinase (RTK)-binding site, while the amide moiety is involved in hydrogen bond interactions with the key amino acids in the gate area; this in turn directs the aryl group to the hydrophobic allosteric back pocket of the RTKs in a type II-like binding mode.	Hydrogen	268-276	kinase insert domain receptor	Homo sapiens	51-58
31468366-5	2020	Here we report the resonance assignment of the backbone 1H and 15N nuclei of K-Ras wildtype, G12C, G12D and G12V proteins" catalytic G domain (1-169 residues) in GDP-bound state, and 13C of backbone and side chains of G12C mutant at physiological pH 7.4.	Hydrogen	56-58	KRAS proto-oncogene, GTPase	Homo sapiens	77-82
22612233-3	2012	The IR spectrum in the O-H stretching region reveals the absence of an intramolecular O-H   F hydrogen bond in the syn-o-trifluoromethylphenol, which is in contrast to the results reported in the literature.	Hydrogen	94-102	synemin	Homo sapiens	115-118
32179690-6	2020	The structure, along with additional high-resolution crystal structures of several analogs in complex with RalA, confirm the importance of key hydrogen bond anchors between compound sulfone oxygen atoms and Ral backbone nitrogen atoms.	Hydrogen	143-151	RAS like proto-oncogene A	Homo sapiens	107-111
22532673-8	2012	Modeling of E9L suggested that the T I change at position 831 might abolish hydrogen bonds between E9L and the DNA backbone and have a direct impact on the incorporation of the acyclic nucleoside phosphonates.	Hydrogen	76-84	DNA polymerase	Vaccinia virus	12-15
22532673-8	2012	Modeling of E9L suggested that the T I change at position 831 might abolish hydrogen bonds between E9L and the DNA backbone and have a direct impact on the incorporation of the acyclic nucleoside phosphonates.	Hydrogen	76-84	DNA polymerase	Vaccinia virus	99-102
32179690-6	2020	The structure, along with additional high-resolution crystal structures of several analogs in complex with RalA, confirm the importance of key hydrogen bond anchors between compound sulfone oxygen atoms and Ral backbone nitrogen atoms.	Hydrogen	143-151	RAN pseudogene 1	Homo sapiens	107-110
32129389-6	2020	TaP, NbAs, and TaAs) also exhibit increased hydrogen evolution activity.	Hydrogen	44-52	nuclear RNA export factor 1	Homo sapiens	0-3
22705373-5	2012	Surprisingly, one c-di-GMP molecule binds to the central crevice of a STING dimer, using a series of stacking and hydrogen bonding interactions.	Hydrogen	114-122	5'-nucleotidase, cytosolic II	Homo sapiens	23-26
32149286-2	2020	The effect of surface chemical groups (SiO-/SiOH2+) on SiO2-Ag0-NPs along with the average negative charge induced by (CH3)2COH  radicals on the catalytic reduction of H2O/H3O+ towards the hydrogen evolution reaction (HER) is reported.	Hydrogen	189-197	H3 clustered histone 15	Homo sapiens	168-175
32129366-2	2020	We utilized the advantages of a para-hydrogen (p-H2) quantum-solid matrix host to perform efficient reactions of hydrogen atoms with CH3CONH2.	Hydrogen	37-45	polyhomeotic homolog 2	Homo sapiens	47-51
22642831-2	2012	Within the active site of Fms1, His67 is positioned to form hydrogen bonds with the polyamine substrate.	Hydrogen	60-68	polyamine oxidase	Saccharomyces cerevisiae S288C	26-30
22581429-5	2012	Cells attached onto a graphite electrode were found to catalyze H(2) production for cathode potentials more reducing than -900 mV vs. standard hydrogen electrode.	Hydrogen	143-151	relaxin 2	Homo sapiens	64-68
32129366-2	2020	We utilized the advantages of a para-hydrogen (p-H2) quantum-solid matrix host to perform efficient reactions of hydrogen atoms with CH3CONH2.	Hydrogen	113-121	polyhomeotic homolog 2	Homo sapiens	47-51
31780179-3	2020	Molecular docking analysis suggested that IMI docks into the active site of AR successfully and that three key hydrogen bonds were formed with the active site residues Glu11, Gln41 and Lys138.	Hydrogen	111-119	androgen receptor	Mus musculus	76-78
32070101-8	2020	And the Cu-doping can strengthen the orbital hybridization of H1s and O2p favoring the hydrogen adsorption/desorption, as well as improve the electrical conductivity.	Hydrogen	87-95	immunoglobulin kappa variable 1D-39	Homo sapiens	70-73
22537606-3	2012	The glucaminium-based coating was developed to exploit the hydrogen bond-acidic hydroxyl groups within the carbohydrate moiety of the PIL in addition to dispersive capabilities resulting from the cation and anion.	Hydrogen	59-67	serpin family A member 2 (gene/pseudogene)	Homo sapiens	134-137
32053379-2	2020	In 1.0 mol dm-3 NaBD4 aqueous solutions, about 5.6 +- 1.6 water molecules bond to BD4- via tetrahedral edges or tetrahedral corners without a very specific hydration geometry; that is, each hydrogen atom of BD4- bonds to 2.2 +- 1.0 water molecules through dihydrogen bonds with the D(B)   D(W) distance of 1.95 A.	Hydrogen	190-198	defensin beta 104A	Homo sapiens	82-85
22568690-4	2012	The influence of the substituent R(2) on the coefficient b of the LSE relationship according to Kamlet-Taft and Catalan, which reflects the quantitative influence of the hydrogen-bonding acceptor or the electron-pair donor capacity of the solvent on the position of the UV-vis absorption maximum, can be determined via a linear Hammett relationship [b = f(sigma(p))].	Hydrogen	170-178	sialic acid acetylesterase	Homo sapiens	66-69
32035750-4	2020	Molecular docking studies indicated that 12Aj appeared to form stable hydrogen bonds with either Aurora A or Aurora B.	Hydrogen	70-78	aurora kinase B	Homo sapiens	109-117
31984387-0	2020	Modular synthesis of (C-10 to C-13)-substituted-9,14-diaryl-9,14-dihydrodibenzo[a,c]phenazines via a subsequent Buchwald-Hartwig amination and C-H amination strategy.	Hydrogen	143-146	homeobox C13	Homo sapiens	30-34
32104537-0	2020	Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats.	Hydrogen	0-8	heme oxygenase 1	Rattus norvegicus	81-85
32104537-6	2020	Furthermore, H2 inhalation reduced the expression of Bcl-2-associated X protein (BAX) and caspase-3 while promoting the expression of Bcl-2, nuclear factor erythroid-2-related factor 2, and heme oxygenase-1 (HO-1).	Hydrogen	13-15	heme oxygenase 1	Rattus norvegicus	190-206
32104537-6	2020	Furthermore, H2 inhalation reduced the expression of Bcl-2-associated X protein (BAX) and caspase-3 while promoting the expression of Bcl-2, nuclear factor erythroid-2-related factor 2, and heme oxygenase-1 (HO-1).	Hydrogen	13-15	heme oxygenase 1	Rattus norvegicus	208-212
32104537-8	2020	Inhibitors of MAPKs blocked H2-induced HO-1 expression.	Hydrogen	28-30	heme oxygenase 1	Rattus norvegicus	39-43
32104537-9	2020	HO-1 small interfering RNA decreased the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) and sirtuin 1 (SIRT1) and reversed the protectivity of H2 against OGD/R-induced cell death.	Hydrogen	192-194	heme oxygenase 1	Rattus norvegicus	0-4
32053964-7	2020	Molecular docking studies of the synthesized 1,2-disubstituted benzimidazoles in the VEGFR-2 active site displayed their ability to accomplish the essential hydrogen bonding and hydrophobic interactions for optimum inhibitory activity.	Hydrogen	157-165	kinase insert domain receptor	Homo sapiens	85-92
31017307-10	2020	Lowering endogenous production of H2 S by concomitant silencing of cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) favoured VIC calcification.	Hydrogen	34-36	cystathionine gamma-lyase	Homo sapiens	67-92
31017307-10	2020	Lowering endogenous production of H2 S by concomitant silencing of cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) favoured VIC calcification.	Hydrogen	34-36	cystathionine gamma-lyase	Homo sapiens	94-97
31017307-13	2020	Valvular calcification in ApoE-/- mice on a high-fat diet was inhibited by H2 S. CONCLUSIONS AND IMPLICATIONS: The endogenous CSE-CBS/H2 S system exerts anti-calcification effects in heart valves providing a novel therapeutic approach to prevent hardening of valves.	Hydrogen	75-77	cystathionine gamma-lyase	Homo sapiens	126-129
31660632-5	2020	Previous work confirmed the modulatory roles of H2 S in BDNF protein expression and autophagy.	Hydrogen	48-50	brain-derived neurotrophic factor	Rattus norvegicus	56-60
22419765-8	2012	The models identified hydrophobic regions, hydrogen bond donor and hydrogen bond acceptor sites, and an ionizable (cationic) feature as key determinants for ligand binding to MATE1.	Hydrogen	43-51	solute carrier family 47 member 1	Homo sapiens	175-180
22419765-8	2012	The models identified hydrophobic regions, hydrogen bond donor and hydrogen bond acceptor sites, and an ionizable (cationic) feature as key determinants for ligand binding to MATE1.	Hydrogen	67-75	solute carrier family 47 member 1	Homo sapiens	175-180
21621588-3	2012	We have reported that molecular hydrogen has potential as an effective antioxidant for medical applications [Ohsawa et al., Nat.	Hydrogen	32-40	bromodomain containing 2	Homo sapiens	124-127
22505335-2	2012	Intramolecular hydrogen bonding within the aldol products forming a six-membered ring enabled the assignment of stereochemistries of the major and minor diastereomers via analysis of the syn and anti (3)J(H,H) (1)H NMR coupling constants.	Hydrogen	15-23	synemin	Homo sapiens	187-190
21643835-0	2012	1H, 15N and 13C assignments of an intramolecular LMO4-LIM1/CtIP complex.	Hydrogen	0-2	LIM domain only 4	Homo sapiens	49-53
21644056-0	2012	1H, 13C, and 15N NMR assignments for the helicase interaction domain of Staphylococcus aureus DnaG primase.	Hydrogen	0-2	AT695_RS04865	Staphylococcus aureus	41-49
21732054-0	2012	1H, 13C and 15N backbone and side-chain resonance assignments of Drosophila melanogaster Ssu72.	Hydrogen	0-2	Ssu72 CTD phosphatase	Drosophila melanogaster	89-94
22326245-1	2012	A simple method with high efficiency for generating high pure hydrogen by hydrolysis in tap water of highly activated aluminum dross is established.	Hydrogen	62-70	nuclear RNA export factor 1	Homo sapiens	88-91
22356513-6	2012	Of particular interest was the Val variant commonly found in the protein elastin, which contained a 25% population of irregular beta turns containing two peptide hydrogen bonds to the proline C O.	Hydrogen	162-170	elastin	Homo sapiens	73-80
31610423-6	2020	Meanwhile, both Rao and Rad acquired from 1H NMR spectra could serve as reliable oxidative indicators to gauge total oxidation of EC oleogels during storage.	Hydrogen	42-44	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	24-27
22173094-3	2012	A conserved Arg residue (Arg375 in iNOS) forms hydrogen bonds with the H(4)B ring.	Hydrogen	47-55	H4 clustered histone 4	Homo sapiens	71-76
22235835-5	2012	Gas-phase HDX-ETD experiments on ubiquitin ions ionized from both denaturing and native solution conditions suggest that residue-specific HDX of side-chain hydrogens is sensitive to secondary and tertiary structural features occurring in both near-native and unfolded gas-phase conformers present shortly after electrospray.	Hydrogen	156-165	Ubiquitin-63E	Drosophila melanogaster	33-42
32005101-13	2020	For Danish Jersey, wavenumbers that interact with C-H were associated to genes that are involved in fatty acid synthesis, such as AGPAT3, AGPAT6, PPARGC1A, SREBF1, and FADS1.	Hydrogen	50-53	1-acylglycerol-3-phosphate O-acyltransferase 3	Bos taurus	130-136
22248451-9	2012	Our neutron model provides insights into the molecular stability of TTR related to the hydrogen-bond network, the pH sensitivity and the CH   O weak hydrogen bond.	Hydrogen	87-95	transthyretin	Homo sapiens	68-71
32071922-0	2020	Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB Signaling Pathway.	Hydrogen	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	135-139
31894781-8	2020	This jump reorientation dynamics is different compared to normal hydrogen bonding reported by Laage and Hynes: it has a short lifetime, around 50-100 fs computed from SHB(t).	Hydrogen	65-73	SH2 domain containing adaptor protein B	Homo sapiens	167-170
21681549-4	2012	Analysis of gene expression data with one-way ANOVA, geNorm and NormFinder identified HIST and YWHAZ as the least affected during the induction of apoptosis by the different treatments, and is the most suitable gene-pair for normalization during qPCR analysis in MCF-7 breast cancer cells undergoing apoptosis following treatment with SA and/or HS.	Hydrogen	345-347	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	95-100
31654544-5	2020	This unique structure makes Pt 1 /def-TiO 2 exhibit a recorded-level photocatalytic hydrogen production performance with an unexpectedly high turnover frequency of 51423 h -1 , exceeding the Pt nanoparticles supported TiO 2 catalyst by a factor of 591.	Hydrogen	84-92	UTP25 small subunit processome component	Homo sapiens	34-37
22159602-3	2012	The results indicate that the contact of CD44 with HA is dominated by hydrogen bonding with small contribution of hydrophobic interactions and salt bridges.	Hydrogen	70-78	CD44 antigen	Mus musculus	41-45
31924176-0	2020	Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.	Hydrogen	0-8	gasdermin D	Mus musculus	70-75
31924176-2	2020	Hydrogen exerts a biphasic effect on cancer by promoting tumor cell death and protecting normal cells, which might initiate GSDMD pathway-mediated pyroptosis.	Hydrogen	0-8	gasdermin D	Mus musculus	124-129
31924176-13	2020	CONCLUSIONS: This study extended our original analysis of the ability of hydrogen to stimulate NLRP3 inflammasome/GSDMD activation in pyroptosis and revealed possible mechanism (s) for improvement of anti-tumor effects in the clinical management of endometrial cancer.	Hydrogen	73-81	gasdermin D	Mus musculus	114-119
31914153-6	2020	Combined with 3D-structural analysis of other MSX1 mutations, we propose that there is a correlation between the observed phenotypes and alterations in hydrogen bond formation, thereby potentially affecting protein binding.	Hydrogen	152-160	msh homeobox 1	Homo sapiens	46-50
22001404-2	2012	TBP are bound to DNA with covalent phosphotriester or non-covalent ion and hydrogen bonds.	Hydrogen	75-83	TATA-box binding protein	Homo sapiens	0-3
31806266-6	2020	In the molecular docking simulation, the South sugar conformation of compound 3e formed additional hydrogen bonds inside the PPARdelta ligand-binding pocket compared with the North conformation.	Hydrogen	99-107	peroxisome proliferator activated receptor delta	Homo sapiens	125-134
22109680-3	2012	We show that these molecules weakly adsorb on water ice and NAT by hydrogen bonding.	Hydrogen	67-75	bromodomain containing 2	Homo sapiens	60-63
31591627-3	2019	Through direct application of this method to compute an ensemble of classical trajectories, we discuss the critical role of isoleucine-839 in modulating the primary hydrogen transfer event in SLO-1.	Hydrogen	165-173	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	192-197
22830351-2	2012	Moreover, all three compounds transform rapidly in the pH range 5-10, CMC 2.5 largely in one step, and CMC 2.24 and curcumin first in a rapid process to an intermediate form that still displays an enolic and two phenolic hydrogen-ion equilibria, and then more slowly to forms absorbing primarily in the lower UV and lacking the strong absorbance in the visible characteristic of the enol-centered chromophore.	Hydrogen	221-229	C-X9-C motif containing 2	Homo sapiens	103-108
31508642-2	2019	These regimes are defined by the relative rate of reaction, k, compared to deltaomega, the frequency of the NMR signal oscillations associated with the coherent evolution of the hyperpolarised 1H NMR signals created after para-hydrogen (p-H2) addition during the pump-probe delay.	Hydrogen	193-195	polyhomeotic homolog 2	Homo sapiens	237-241
22876134-15	2012	Hydrogen bond-interaction between ALCAR and amino acid residues at the functional domain regions of connexin 46 and connexin 50 proteins was also demonstrated through bioinformatics tools.	Hydrogen	0-8	gap junction protein, alpha 3	Rattus norvegicus	100-111
22876134-15	2012	Hydrogen bond-interaction between ALCAR and amino acid residues at the functional domain regions of connexin 46 and connexin 50 proteins was also demonstrated through bioinformatics tools.	Hydrogen	0-8	gap junction protein, alpha 8	Rattus norvegicus	116-127
31508642-2	2019	These regimes are defined by the relative rate of reaction, k, compared to deltaomega, the frequency of the NMR signal oscillations associated with the coherent evolution of the hyperpolarised 1H NMR signals created after para-hydrogen (p-H2) addition during the pump-probe delay.	Hydrogen	227-235	polyhomeotic homolog 2	Homo sapiens	237-241
23189173-2	2012	To understand the molecular mechanism of EPAC activation, we have combined site-directed mutagenesis, X-ray crystallography, and peptide amide hydrogen/deuterium exchange mass spectrometry (DXMS) to probe the structural and conformational dynamics of EPAC2-F435G, a constitutively active EPAC2 mutant.	Hydrogen	143-151	Rap guanine nucleotide exchange factor 3	Homo sapiens	41-45
31496313-6	2019	The results of molecular docking showed that the binding between EF-5 and tyrosinase was determined majorly by hydrogen bonds and hydrophobic interactions.	Hydrogen	111-119	tyrosinase	Homo sapiens	65-84
23056199-2	2012	This study shows direct evidence for an intramolecular hydrogen bond between the reducing ring HO3 hydroxyl group and the non-reducing ring oxygen (O5") that has been previously predicted by computation and NMR analysis.	Hydrogen	55-63	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	95-98
23056199-3	2012	Moreover, this work shows that hydrogen bonding to the non-reducing ring O5" oxygen is shared between water and the HO3 hydroxyl group with an average of 50% occupancy by each hydrogen-bond donor.	Hydrogen	31-39	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	116-119
23056199-3	2012	Moreover, this work shows that hydrogen bonding to the non-reducing ring O5" oxygen is shared between water and the HO3 hydroxyl group with an average of 50% occupancy by each hydrogen-bond donor.	Hydrogen	176-184	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	116-119
31538686-3	2019	For spin crossover in first-row transition metals coordinated by hydrogen, nitrogen, and carbon monoxide, we find the pressure required for spin transition to be a function of ligand position in the spectrochemical sequence.	Hydrogen	65-73	spindlin 1	Homo sapiens	4-8
22860101-5	2012	Here, we suggested a novel computational procedure, which combines with homology modeling, rigid body docking, free and steered molecular dynamics (MD) simulations, to identify key paratope residues on 6B4 and their partners on GPIbalpha, with hypothesis that the stable hydrogen bonds and salt bridges are the important linkers between paratope and epitope residues.	Hydrogen	271-279	glycoprotein Ib platelet subunit alpha	Homo sapiens	228-237
31538686-3	2019	For spin crossover in first-row transition metals coordinated by hydrogen, nitrogen, and carbon monoxide, we find the pressure required for spin transition to be a function of ligand position in the spectrochemical sequence.	Hydrogen	65-73	spindlin 1	Homo sapiens	140-144
31760915-1	2019	FoxF1-ATPases of mitochondria, chloroplasts, and microorganisms catalyze transformation of proton motive force (the difference between the electrochemical potentials of hydrogen ion across a coupling membrane) to the free energy of ATP phosphoryl potential.	Hydrogen	169-177	forkhead box F1	Homo sapiens	0-5
31281983-0	2019	Effects of Electronic Structure of Adjacent Carbon on the Strength of C F H F Organofluorine Hydrogen Bonds.	Hydrogen	93-101	complement factor H	Homo sapiens	70-75
31281983-1	2019	We investigate the effects of the electronic structure of carbon atom on the organofluorine hydrogen bonds, C F H F. Our results show that we can modulate the strength of organofluorine hydrogen bonds by adjusting the volume of fluorine atom in C F via changing the electronic structure of adjacent carbon atoms.	Hydrogen	186-194	complement factor H	Homo sapiens	108-113
31281983-2	2019	Different with the conventional hydrogen bonds, we found that instead of carbon rehybridization and hyperconjugative effects, the magnitude of fluorine atomic volume plays important roles in determining the strength of the C F H F organofluorine hydrogen bonds.	Hydrogen	32-40	complement factor H	Homo sapiens	223-228
31281983-2	2019	Different with the conventional hydrogen bonds, we found that instead of carbon rehybridization and hyperconjugative effects, the magnitude of fluorine atomic volume plays important roles in determining the strength of the C F H F organofluorine hydrogen bonds.	Hydrogen	246-254	complement factor H	Homo sapiens	223-228
31281983-3	2019	The lone pair electrons at both the proximal and the vicinal carbon dramatically reinforce the strength of C F H F organofluorine hydrogen bond with its interaction energy in the range of about 15-25 kcal/mol, that is, the carbanion-mediated organofluorine hydrogen bond could be very strong.	Hydrogen	130-138	complement factor H	Homo sapiens	107-112
31281983-3	2019	The lone pair electrons at both the proximal and the vicinal carbon dramatically reinforce the strength of C F H F organofluorine hydrogen bond with its interaction energy in the range of about 15-25 kcal/mol, that is, the carbanion-mediated organofluorine hydrogen bond could be very strong.	Hydrogen	257-265	complement factor H	Homo sapiens	107-112
31603152-1	2019	Reaction of the dimeric calcium hydride, [(BDI)CaH]2 (1), with Ph3SnH ensues with elimination of H2 to provide [(BDI)Ca-mu2-H-(SnPh3)Ca(BDI)] (3) and [(BDI)Ca(SnPh3)]2 (4) alongside dismutation to Ph4Sn, H2 and Sn(0).	Hydrogen	97-99	relaxin 2	Homo sapiens	197-206
31556889-4	2019	As extended hydrogen bond networks and proton exchange are at the heart of these mechanisms, here we report our results on a prototypical characterisation of proton exchange in a PIL (C2HimNTf2)-water mixture.	Hydrogen	12-20	serpin family A member 2 (gene/pseudogene)	Homo sapiens	179-182
31468690-4	2019	CTH promotes NF-kappaB nuclear translocation through H2 S-mediated sulfhydration on cysteine-38 of the NF-kappaB p65 subunit, resulting in increased IL-1beta expression and H2 S-induced cell invasion.	Hydrogen	53-55	cystathionine gamma-lyase	Homo sapiens	0-3
31468690-6	2019	Together, our findings provide evidence that CTH generated H2 S promotes prostate cancer progression and metastasis through IL-1beta/NF-kappaB signaling pathways.	Hydrogen	59-61	cystathionine gamma-lyase	Homo sapiens	45-48
31199181-5	2019	The co-crystal structure of the antigen-binding fragment bound to a CD52 peptide mimetic was solved at 2.2A (PDB code 6OBD), which revealed that Asn33 directly interacts with the CD52 phosphate group via a hydrogen bond.	Hydrogen	206-214	CD52 molecule	Homo sapiens	68-72
31199181-5	2019	The co-crystal structure of the antigen-binding fragment bound to a CD52 peptide mimetic was solved at 2.2A (PDB code 6OBD), which revealed that Asn33 directly interacts with the CD52 phosphate group via a hydrogen bond.	Hydrogen	206-214	CD52 molecule	Homo sapiens	179-183
30815791-0	2019	1H-MRS Quantitation of Age-Dependent Taurine Changes in Mouse Brain.	Hydrogen	0-2	renin binding protein	Mus musculus	23-26
31146155-9	2019	The LC-PCB sulfates formed hydrogen bond interaction with arginine 228 residue of TRalpha by their sulfate groups, which might facilitate the TR binding and agonistic activity.	Hydrogen	27-35	T cell receptor alpha locus	Homo sapiens	82-89
31575191-2	2019	Here, we analyze in detail the electric fields due to the polarization of the hydrogen bond on the DNA base pairs and derive, within a tight binding analytical band folding approach, an intrinsic Rashba coupling which should dictate the order of the spin active effects in the chiral-induced spin selectivity effect.	Hydrogen	78-86	spindlin 1	Homo sapiens	292-296
31271801-8	2019	Docking simulations showed binding affinities of compounds 1 to 5 for hMAO-B were higher than those for hMAO-A or AChE and suggested these five chalcones form hydrogen bonds with MAO-B at Cys172 but that they do not form hydrogen bonds with hMAO-A or AChE.	Hydrogen	159-167	monoamine oxidase B	Homo sapiens	70-76
31271801-8	2019	Docking simulations showed binding affinities of compounds 1 to 5 for hMAO-B were higher than those for hMAO-A or AChE and suggested these five chalcones form hydrogen bonds with MAO-B at Cys172 but that they do not form hydrogen bonds with hMAO-A or AChE.	Hydrogen	159-167	monoamine oxidase B	Homo sapiens	71-76
31271801-8	2019	Docking simulations showed binding affinities of compounds 1 to 5 for hMAO-B were higher than those for hMAO-A or AChE and suggested these five chalcones form hydrogen bonds with MAO-B at Cys172 but that they do not form hydrogen bonds with hMAO-A or AChE.	Hydrogen	221-229	monoamine oxidase B	Homo sapiens	70-76
31271801-8	2019	Docking simulations showed binding affinities of compounds 1 to 5 for hMAO-B were higher than those for hMAO-A or AChE and suggested these five chalcones form hydrogen bonds with MAO-B at Cys172 but that they do not form hydrogen bonds with hMAO-A or AChE.	Hydrogen	221-229	monoamine oxidase B	Homo sapiens	71-76
32624969-10	2019	The emergence of surface plasmon resonance (SPR) sensing with optical fibers coupled with the H2-sensitive metal palladium, allows detection of dissolved hydrogen in liquid.	Hydrogen	154-162	relaxin 2	Homo sapiens	94-96
31483550-5	2019	Results from obtained data showed that H2 S decreased the expression of SRA, Grp78, PERK, CHOP and Caspase-3, and increased that of LC3-II/LC3-I, in addition to alleviating the pathological changes of liver and reducing the levels of ALT, AST, LDH TBARS and MDA.	Hydrogen	39-41	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	77-82
31291611-7	2019	Molecular docking indicated potential interactions of demethylbellidifolin (1) with HCE 2 through two hydrogen bonds of the C-3 and C-5 hydroxy groups with amino acid residues Glu227 and Ser228 in the catalytic cavity, respectively.	Hydrogen	102-110	complement C3	Homo sapiens	124-127
31524220-10	2019	In addition, it was demonstrated that hydrogen exerted an anti-inflammatory and anti-apoptotic effect in myocardial cells induced by H/R via PINK1/Parkin mediated autophagy.	Hydrogen	38-46	PTEN induced kinase 1	Rattus norvegicus	141-146
22792045-1	2012	Under dark anoxia, the unicellular green algae Chlamydomonas reinhardtii may produce hydrogen by means of its hydrogenase enzymes, in particular HYD1, using reductants derived from the degradation of intercellular carbon stores.	Hydrogen	85-93	uncharacterized protein	Chlamydomonas reinhardtii	145-149
31524220-12	2019	In summary, the present study indicated that treatment with hydrogen-rich saline improved the inflammatory response and apoptosis in MI/R via PINK1/Parkin-mediated mitophagy.	Hydrogen	60-68	PTEN induced kinase 1	Rattus norvegicus	142-147
30961746-4	2019	Consequently, the Ni/Zr-Sil-1 catalyst exhibited the best catalytic performance, with the CO selectivity in methane steam reforming drastically decreasing by 11.5%, H2 concentration in the reformed gas increasing by about 1.7%, and H2/CO molar ratio increasing by 0.8.	Hydrogen	165-167	SIL1 nucleotide exchange factor	Homo sapiens	24-29
31213525-7	2019	Hydrogen-deuterium exchange MS (HDX-MS) of p38alpha performed at 33, 37, and 39.5  C indicated temperature-dependent conformational changes in an alpha helix near the common docking and glutamate:aspartate substrate-binding domains at the known binding site for MK2.	Hydrogen	0-8	MAPK activated protein kinase 2	Homo sapiens	262-265
31497598-2	2019	In this paper, critical genes (HydA1, Hyd A2, Sulp, Tla1, Sta7, PFL1) involved in H2 metabolism were identified and analyzed for their function in H2 accumulation.	Hydrogen	82-84	uncharacterized protein	Chlamydomonas reinhardtii	64-68
31338492-4	2019	Through a GGT-mediated enzymatic reaction, the aggregation state of the probe in aqueous solution was changed and an intramolecular hydrogen bond was formed, resulting in an enhanced fluorescence emission.	Hydrogen	132-140	inactive glutathione hydrolase 2	Homo sapiens	10-13
31318005-1	2019	In this work, we prepared locust bean gum (LBG)/gellan gum (Gg) double network (DN) hydrogels based on pH-sensitive borate-ester bonds in the LBG network and hydrogen-bond-associated double-helix bundles in the Gg network by using two novel natural polysaccharide polymers.	Hydrogen	158-166	brain expressed associated with NEDD4 1	Homo sapiens	33-37
31373284-6	2019	H2-TPR and H2-TPD revealed that the activity of the catalysts was closely related to the adsorption property for hydrogen.	Hydrogen	113-121	translocated promoter region, nuclear basket protein	Homo sapiens	3-6
31292739-11	2019	The decomposition pathway for syn-dihydropyrene is also hemolytic in cleavage when the internal groups are methyl and hydrogen.	Hydrogen	118-126	synemin	Homo sapiens	30-33
29847499-0	2019	Hydrogen-Rich Saline Attenuates Acute Lung Injury Induced by Limb Ischemia/Reperfusion via Down-Regulating Chemerin and NLRP3 in Rats.	Hydrogen	0-8	retinoic acid receptor responder 2	Rattus norvegicus	107-115
29847499-2	2019	The hypothesis of this study is that hydrogen-rich solution could attenuateacute lung injury and improve mortality via chemerin and NLRP3 after LI/R in rats.	Hydrogen	37-45	retinoic acid receptor responder 2	Rattus norvegicus	119-127
31242734-5	2019	We find that intermolecular hydrogen bonding to the free O-H group in catechol increases its first excited singlet state (S1) lifetime by 2 orders of magnitude (i.e., ~ 16 to 1410 ps), and that O-H bond dissociation is prevented because Et2O is a poor hydrogen atom acceptor.	Hydrogen	28-36	endothelin 2	Homo sapiens	237-240
31172362-5	2019	Using over 400 molecules with known half maximal inhibitory concentrations (IC50) for BTK, a four-point pharmacophore hypothesis was derived, with two aromatic rings (R), one hydrogen bond acceptor (A) and one hydrogen bond donor (D).	Hydrogen	175-183	Bruton tyrosine kinase	Homo sapiens	86-89
31172362-5	2019	Using over 400 molecules with known half maximal inhibitory concentrations (IC50) for BTK, a four-point pharmacophore hypothesis was derived, with two aromatic rings (R), one hydrogen bond acceptor (A) and one hydrogen bond donor (D).	Hydrogen	210-218	Bruton tyrosine kinase	Homo sapiens	86-89
31103039-0	2019	Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation.	Hydrogen	0-8	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	172-176
31087870-7	2019	After 48h, the hydrogen production rate of CA-H, CA-M, CA-L was 21.45, 28.60, and 22.75 times higher than CK.	Hydrogen	15-23	calmodulin-lysine N-methyltransferase	Homo sapiens	49-53
30975455-4	2019	The results reveal that the first and third loops and the C-terminal helix regions of the U1A domain undergo a significant loss of flexibility upon the RNA binding due to the forming of mostly electrostatic and hydrogen bond interactions with RNA 5" stem and loop.	Hydrogen	211-219	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	90-93
30974944-3	2019	With the IC50 value of 2.4 muM, compound 1 could directly bind to the catalytic pocket of PTP1B through a series of hydrogen bonds.	Hydrogen	116-124	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	90-95
30743173-7	2019	The molecular modeling study showed a high affinity and selectivity of our synthesized compounds to the active site and B-site of PTP1B holding hydrogen bonding, hydrophobic, and electrostatic interactions.	Hydrogen	144-152	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	130-135
30885432-5	2019	Here, we have generated a range of Prx mutants with either a decreased or knocked out ability to stack, and used both imaging and solution studies to show that Prx stacks through electrostatic interactions that are stabilised by a hydrogen bonding network.	Hydrogen	231-239	peroxiredoxin 3	Homo sapiens	35-38
30938392-6	2019	Using molecular modelling and 2D NMR analyses, this work illustrates that covalent links and hydrogen-bonding interactions between side-chains can bias the conformation in favour of the alpha-helix mimicking syn-conformer, offering insight that may be more widely applied to control secondary structure in foldamers.	Hydrogen	93-101	synemin	Homo sapiens	208-211
31933966-0	2019	Protective effects of hydrogen-rich saline against renal ischemia-reperfusion injury by increased expression of heme oxygenase-1 in aged rats.	Hydrogen	22-30	heme oxygenase 1	Rattus norvegicus	112-128
22020288-0	2011	Drug discovery targeting human 5-HT(2C) receptors: residues S3.36 and Y7.43 impact ligand-binding pocket structure via hydrogen bond formation.	Hydrogen	119-127	5-hydroxytryptamine receptor 2C	Homo sapiens	31-38
22199924-5	2011	The carbonyl O atom bonded to the thia-zole ring is involved in two C-H O hydrogen-bond inter-actions forming centrosymmetric dimers; the ten- and six-membered rings resulting from these inter-actions have R(2) (2)(10) and R(1) (2)(6) motifs, respectively.	Hydrogen	74-82	CD1e molecule	Homo sapiens	206-210
22041171-5	2011	Particularly, some of these compounds (e.g., 1b and 1h) showed low nanomolar K(I) values and excellent selectivity for hCA IX and hCA XIV versus hCA I and II inhibition.	Hydrogen	52-54	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	145-157
22468541-4	2011	Hydrogen temperature programmed reduction (H2-TPR) and nitrogen adsorption-desorption experiment results showed that the size and pore structure of Co3O4 nanorods could be affected by different reaction time and pH, and led to the difference in specific surface area.	Hydrogen	43-45	translocated promoter region, nuclear basket protein	Homo sapiens	46-49
21802168-12	2011	There was no observed significant change in cytokine in any model following the impairment of intracellular Ca2+ except in the case of macrophage/Jurkat cell model in which IL-12 and IL-10 were upregulated in 1h or 3 h, respectively.	Hydrogen	209-211	interleukin 10	Homo sapiens	183-188
21978662-0	2011	14N quadrupole resonance and 1H T1 dispersion in the explosive RDX.	Hydrogen	29-31	radixin	Homo sapiens	63-66
21978662-1	2011	The explosive hexahydro-1,3,5-trinitro-s-triazine (CH2-N-NO2)3, commonly known as RDX, has been studied by 14N NQR and 1H NMR.	Hydrogen	119-121	radixin	Homo sapiens	82-85
21956195-8	2011	Anti-inflammatory and antiapoptotic heme oxygenase-1 was significantly upregulated in the hydrogen-treated graft muscularis but not mucosa before reperfusion.	Hydrogen	90-98	heme oxygenase 1	Rattus norvegicus	36-52
21988105-0	2011	Neutron structure of human carbonic anhydrase II: a hydrogen-bonded water network "switch" is observed between pH 7.8 and 10.0.	Hydrogen	52-60	carbonic anhydrase 2	Homo sapiens	27-48
21842493-6	2011	Hydrogen bonding with amino acid residues Asp74, Ala29, and Asn27 may be an important determinant for HO-PBDEs binding to TTR.	Hydrogen	0-8	transthyretin	Homo sapiens	122-125
21839154-5	2011	Raman spectrum microscopy confirmed that mouse PPy/u containing-plasmid DNA molecules under the different structural strains have a different configuration of ring bases as well as altered Hoogsteen hydrogen bonds.	Hydrogen	199-207	pancreatic polypeptide	Mus musculus	47-50
21932829-9	2011	Uracil bears a triple hydrogen bond motif of the form acceptor-donor-acceptor (ADA) and is a direct antagonist of 2,4-diaminotriazine.	Hydrogen	22-30	adenosine deaminase	Homo sapiens	54-83
21424594-7	2011	And the major difference about binding mode from the crystal structures of beta(1)- and beta(2)-ARs is the hydrogen-bonding interaction with the residue Arg315, which corresponds to the residue Asn313 of beta(1)-AR and the residue His296 of beta(2)-AR, respectively.	Hydrogen	107-115	adrenoceptor beta 2	Homo sapiens	88-98
21870866-3	2011	LERE-QSAR analysis quantitatively revealed that the complex formation is driven by hydrogen-bonding and electrostatic interaction of hNEU2 with sialic acid analogues.	Hydrogen	83-91	neuraminidase 2	Homo sapiens	133-138
21826294-4	2011	The DFT calculations using B3LYP 6-31G* supported the abovementioned inverse reactivity, and also suggested the presence of an accelerating effect by the carbamoyl group as a result of hydrogen bond formation with a dipolarophilic nitrile.	Hydrogen	185-193	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	29-32
21879121-5	2011	In our example application of the synthesized materials, we find that these Pt-SnO(2) films exhibit exceptional hydrogen gas sensing behavior, rapidly detecting low-level hydrogen concentrations at room temperature; for example, an eight order of magnitude change in electrical resistance is seen in response to 10 000 ppm H(2), with only minimal sensitivity to humidity.	Hydrogen	112-120	strawberry notch homolog 2	Homo sapiens	79-82
21879121-5	2011	In our example application of the synthesized materials, we find that these Pt-SnO(2) films exhibit exceptional hydrogen gas sensing behavior, rapidly detecting low-level hydrogen concentrations at room temperature; for example, an eight order of magnitude change in electrical resistance is seen in response to 10 000 ppm H(2), with only minimal sensitivity to humidity.	Hydrogen	171-179	strawberry notch homolog 2	Homo sapiens	79-82
21287302-0	2011	1H, 13C and 15N chemical shift assignments of the thioredoxin from the obligate anaerobe Desulfovibrio vulgaris Hildenborough.	Hydrogen	0-2	DVU0378	Desulfovibrio vulgaris str. Hildenborough	50-61
22069698-0	2011	Hydrogen-bonding interactions in T-2 toxin studied using solution and solid-state NMR.	Hydrogen	0-8	solute carrier family 25 member 5	Homo sapiens	33-36
22069698-1	2011	The structure of T-2 toxin in the solid-state is limited to X-ray crystallographic studies, which lack sufficient resolution to provide direct evidence for hydrogen-bonding interactions.	Hydrogen	156-164	solute carrier family 25 member 5	Homo sapiens	17-20
22069698-7	2011	This result implies that these hydrogen-bonding interactions could play an important role in the biological function of T-2 toxin and posits towards a possible interaction for the trichothecene class of toxins and the ribosome.	Hydrogen	31-39	solute carrier family 25 member 5	Homo sapiens	120-123
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen	18-20	hepcidin antimicrobial peptide	Mus musculus	196-204
26605481-2	2011	Using a computationally generated amylose helix of 55 glucose residues, we have investigated the time-dependent behavior of intra- and intermolecular hydrogen bonds, particularly between O2 and O3 of adjacent glucose molecules and between O6 and neighboring O2 and O3 groups.	Hydrogen	150-158	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	239-267
30672942-5	2019	Both G-1 and G-2 gels show excellent intrinsic self-healing properties based on hydrogen bonds, with healing efficiencies of 91% and 97%, respectively; self-healing between G-1 and G-2 also occurs due to hydrogen bonding and host-guest interactions.	Hydrogen	80-88	proline rich protein BstNI subfamily 3	Homo sapiens	5-16
30672942-5	2019	Both G-1 and G-2 gels show excellent intrinsic self-healing properties based on hydrogen bonds, with healing efficiencies of 91% and 97%, respectively; self-healing between G-1 and G-2 also occurs due to hydrogen bonding and host-guest interactions.	Hydrogen	204-212	proline rich protein BstNI subfamily 3	Homo sapiens	5-16
21823579-9	2011	Furthermore, DUT-30(Zn) exhibits a hydrogen storage capacity of 1.12 wt % at 1 bar, a CO(2) uptake of 200 cm(3) g(-1) at -78  C and 0.9 bar, and a n-butane uptake of 3.0 mmol g(-1) at 20  C. The N(2) adsorption process was monitored in situ via X-ray powder diffraction using synchrotron radiation.	Hydrogen	35-43	deoxyuridine triphosphatase	Homo sapiens	13-16
30672942-5	2019	Both G-1 and G-2 gels show excellent intrinsic self-healing properties based on hydrogen bonds, with healing efficiencies of 91% and 97%, respectively; self-healing between G-1 and G-2 also occurs due to hydrogen bonding and host-guest interactions.	Hydrogen	204-212	proline rich protein BstNI subfamily 3	Homo sapiens	173-184
30611048-3	2019	The above architectures had the larger electrochemically active surface area (ECSA, 36.85 m2 g-1Pt) than that of commercial Pt black (15.85 m2 g-1Pt), along with the improved catalytic characters for hydrogen evolution reaction (HER) and oxygen reduction reaction (ORR) in acid electrolytes alternative to those of Pt black.	Hydrogen	200-208	dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	Homo sapiens	143-148
22058949-1	2011	The title compound, C(7)H(13)NO(5), was prepared by the condensation of O-(carb-oxy-meth-yl)hydroxyl-amine and (Boc)(2)O (Boc = but-oxy-carbon-yl).In the crystal, mol-ecules are linked by weak inter-molecular N-H O hydrogen bonds.	Hydrogen	215-223	BOC cell adhesion associated, oncogene regulated	Homo sapiens	112-115
22064936-3	2011	The hy-droxy and amine groups are almost syn which enables the formation of inter-molecular hy-droxy-OH N(thia-diazo-yl) and amine-H O(sulfon-yl) hydrogen bonds leading to a supra-molecular chain aligned along the a axis.	Hydrogen	146-154	synemin	Homo sapiens	41-44
30776889-1	2019	Dynamic kinetic resolution (DKR) of racemic aryl alpha-amino beta-ketoesters via Ru-diphosphine-catalyzed asymmetric hydrogenation was realized at 70  C under 50 atm of hydrogen, affording syn alpha-amido beta-hydroxy esters in high yields (up to 96%) with high reactivity (TON up to 940) and diastereo- and enantioselectivities (up to 99:1 dr, 98% ee).	Hydrogen	117-125	synemin	Homo sapiens	189-192
21816515-10	2011	Analogically, in a homology model of the 5-HT(2A) receptor, the N-8 atom formed a hydrogen bond with Gly369.	Hydrogen	82-90	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	41-58
30698956-1	2019	We present the development of a perturbative triples correction scheme for the previously reported unitary group based spin-adapted combinatoric open-shell coupled-cluster (CC) singles and doubles (COS-CCSD) approach and report on the applications of the newly developed method, termed "COS-CCSD(T)", to the calculation of hyperfine coupling (HFC) tensors for radicals consisting of hydrogen, second- and third-row elements.	Hydrogen	383-391	spindlin 1	Homo sapiens	119-123
21796302-9	2011	Intriguingly, the carboxyl group demonstrated different bonding patterns with PDE4D and ALOX5AP, through electrostatic interaction and hydrogen bonds, respectively.	Hydrogen	135-143	phosphodiesterase 4D	Homo sapiens	78-83
30862702-3	2019	Here, we investigated the proposed water-mediated, hydrogen-bonded activation switch between the conserved NPxxY motif on transmembrane helix 7 (TMH7) and a conserved tyrosine in TMH5, which contributes to alpha1B-adrenoceptor (alpha1B-AR) and beta2-AR activation.	Hydrogen	51-59	adrenoceptor alpha 1B	Homo sapiens	206-226
21717014-3	2011	Our strategy started from its five 2"-deoxyadenosine residues (A5, A9, A11, A12, and A15) in the loop based on the capability of the N7 atom to form hydrogen bonds in tertiary structures.	Hydrogen	149-157	immunoglobulin kappa variable 1-32 (pseudogene)	Homo sapiens	85-88
21817793-5	2011	Compound (I) forms hydrogen-bonded parallel beta-sheet-like tapes, with the carbonyl groups of Aib1 and Aib2 acting as hydrogen-bond acceptors.	Hydrogen	119-127	ANIB1	Homo sapiens	95-99
30862702-3	2019	Here, we investigated the proposed water-mediated, hydrogen-bonded activation switch between the conserved NPxxY motif on transmembrane helix 7 (TMH7) and a conserved tyrosine in TMH5, which contributes to alpha1B-adrenoceptor (alpha1B-AR) and beta2-AR activation.	Hydrogen	51-59	adrenoceptor alpha 1B	Homo sapiens	228-238
33117975-6	2019	With water-rich mobile phases, the retention behaviour of the TRAP analogues was dominated by enthalpic processes, consistent with the participation of strong hydrogen bonding effects, but became dominated by entropic effects with acetonitrile-rich mobile phases as the temperature was increased.	Hydrogen	159-167	TRAP	Homo sapiens	62-66
21801961-7	2011	Inhaled hydrogen induced heme oxygenase-1, an antioxidant enzyme, in the lung grafts prior to implantation, which might contribute to protective effects afforded by hydrogen.	Hydrogen	8-16	heme oxygenase 1	Rattus norvegicus	25-41
21801961-7	2011	Inhaled hydrogen induced heme oxygenase-1, an antioxidant enzyme, in the lung grafts prior to implantation, which might contribute to protective effects afforded by hydrogen.	Hydrogen	165-173	heme oxygenase 1	Rattus norvegicus	25-41
21723254-5	2011	Hydrogen treatment inhibited LPS/IFNgamma-induced phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) and its downstream signaling molecules, p38 MAP kinase and JNK, as well as IkappaBalpha, but did not affect activation of NADPH oxidase and production of reactive oxygen species (ROS).	Hydrogen	0-8	mitogen-activated protein kinase 8	Mus musculus	172-175
21556397-1	2011	The example of syn-aldol reaction of cyclohexanone to aldehyde was demonstrated based on chiral diamine organocatalysts and it was realized either by increasing the molecular size of acid additives or by introducing a hydrogen-bond donor into acid additives.	Hydrogen	218-226	synemin	Homo sapiens	15-18
21601449-2	2011	The SAR of these ketonethiosemicarbazones revealed that the benzylidene hydrogen in aldehydethiosemicarbazones 1 can be replaced by hydrophobic moiety and substitutions with alkyl group for the terminal amino hydrogen of ketonethiosemicarbazones improved the activity appreciably.	Hydrogen	72-80	sarcosine dehydrogenase	Homo sapiens	4-7
21601449-2	2011	The SAR of these ketonethiosemicarbazones revealed that the benzylidene hydrogen in aldehydethiosemicarbazones 1 can be replaced by hydrophobic moiety and substitutions with alkyl group for the terminal amino hydrogen of ketonethiosemicarbazones improved the activity appreciably.	Hydrogen	209-217	sarcosine dehydrogenase	Homo sapiens	4-7
21645859-0	2011	Fine details of IGF-1R activation, inhibition, and asymmetry determined by associated hydrogen /deuterium-exchange and peptide mass mapping.	Hydrogen	86-94	insulin like growth factor 1 receptor	Homo sapiens	16-22
21645859-2	2011	We investigated hydrogen/deuterium (H/D)-exchange within the extracellular domain of the type-I insulin-like growth factor receptor (IGF-1R) in the absence and presence of IGF-1 (active state) and in the presence of antibody inhibitors (inactive state).	Hydrogen	16-24	insulin like growth factor 1 receptor	Homo sapiens	133-139
21478159-4	2011	Based on the crystal structure of the Cx26 gap junction channel and homology models of heterotypic channels, we analyzed docking selectivity for several hemichannel pairs and found that the hydrogen bonds between E2 domains are conserved in a group of heterotypically compatible hemichannels, including Cx26 and Cx32 hemichannels.	Hydrogen	190-198	gap junction protein beta 1	Homo sapiens	312-316
21426412-8	2011	We postulate that all HPGD mutations constitute loss-of-function alleles due to protein truncation or missense changes that affect hydrogen bonds lining the 15-PGDH enzyme reaction cavity.	Hydrogen	131-139	carbonyl reductase 1	Homo sapiens	22-26
21382498-3	2011	Comparison of the crystal structure of acetyl-YEQGL-amide determined here and that of a complex formed with the mu2 subunit of the clathrin adaptor protein complex AP2 reported previously, reveals differences in conformational properties, although there are nevertheless similarities concerning aspects of the hydrogen-bonding arrangement and the hydrophobic environment of the leucine sidechain.	Hydrogen	310-318	transcription factor AP-2 alpha	Homo sapiens	164-167
21513309-5	2011	CYP2A6-catalyzed (S)-(-)-nicotine 5"-hydroxylation consists of two reaction steps, that is, the hydrogen transfer from the 5"-position of (S)-(-)-nicotine to the oxygen of Cpd I (the H-transfer step), followed by the recombination of the (S)-(-)-nicotine moiety with the iron-bound hydroxyl group to generate the 5"-hydroxynicotine product (the O-rebound step).	Hydrogen	96-104	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
21575181-2	2011	The Ig-fold of the DraD possesses two major characteristics distinguishing it from the family of fimbrial subunits: 1) a distortion of the beta-barrel structure in the region of the acceptor cleft, demonstrated by a disturbance of the main-chain hydrogen bonds network, and 2) an unusually located disulfide bond connecting B and F strands - the localization exclusively observed in the subfamily of DraD/AfaD-type subunits.	Hydrogen	246-254	EGF containing fibulin extracellular matrix protein 1	Homo sapiens	19-23
21473852-7	2011	The early activation of NFkappaB during hydrogen treatment was correlated with elevated levels of the antiapoptotic protein Bcl-2 and decreased levels of Bax.	Hydrogen	40-48	BCL2-associated X protein	Mus musculus	154-157
24900341-2	2011	During our lead optimization for CRTH2 antagonists, an observation of an intramolecular hydrogen bond in ortho-phenylsulfonamido benzophenone derivatives led to the design and synthesis of conformationally constrained benzodiazepinones as potent CRTH2 antagonists.	Hydrogen	88-96	prostaglandin D2 receptor 2	Homo sapiens	33-38
24900341-2	2011	During our lead optimization for CRTH2 antagonists, an observation of an intramolecular hydrogen bond in ortho-phenylsulfonamido benzophenone derivatives led to the design and synthesis of conformationally constrained benzodiazepinones as potent CRTH2 antagonists.	Hydrogen	88-96	prostaglandin D2 receptor 2	Homo sapiens	246-251
21349833-6	2011	We identify the primary cause of inhibition as a failure to activate the nucleotide base as an efficient leaving group and demonstrate that the higher binding affinity of AAG for epsilonC versus epsilonA is achieved through formation of an additional hydrogen bond between Asn-169 in the active site pocket and the O(2) of epsilonC.	Hydrogen	251-259	N-methylpurine DNA glycosylase	Homo sapiens	171-174
21533208-0	2011	A major role for side-chain polyglutamine hydrogen bonding in irreversible ataxin-3 aggregation.	Hydrogen	42-50	ataxin 3	Homo sapiens	75-83
21340057-4	2011	The presence of hydrogen-bond-mediated intermolecular interactions, that involve the methanol molecules, yields dimers of dinuclear units for 1 2MeOH, and infinite zig-zag chains for 2 2MeOH.	Hydrogen	16-24	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	168-171
21361388-9	2011	The additional Fe in Aft1-1(up) cells was present as mononuclear HS Fe(III) species.	Hydrogen	65-67	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	21-25
20924725-0	2011	1H, 13C, 15N backbone and side-chain resonance assignments of the human Raf-1 kinase inhibitor protein.	Hydrogen	0-2	phosphatidylethanolamine binding protein 1	Homo sapiens	72-102
21144647-9	2011	Univariate statistical analysis revealed greater 1H-MRS-detected Cho content (P=0.0444) and lower normalized NAA/Cho ratio (P=0.0203) in tumors with MIB-1 index 5% and more.	Hydrogen	49-51	MIB E3 ubiquitin protein ligase 1	Homo sapiens	149-154
21200321-8	2011	Hydrogen-rich saline treatment significantly reduced the level of degraded myelin basic protein, decreased the expression of ionized calcium-binding adapter molecule 1, Iba1, a microglial marker, reduced DNA oxidation, and suppressed proinflammatory cytokine interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in the cortex and hippocampal tissues when compared with those in normal saline-treated rats.	Hydrogen	0-8	myelin basic protein	Rattus norvegicus	75-95
21219510-8	2011	This analysis shows that the PFL1 pathway has a significant impact on hydrogen metabolism in C. reinhardtii.	Hydrogen	70-78	uncharacterized protein	Chlamydomonas reinhardtii	29-33
21389983-9	2011	A key feature of this conformational change is a reorganization of water-mediated hydrogen-bond networks between the retinal-binding pocket and three of the most conserved GPCR sequence motifs.	Hydrogen	82-90	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	172-176
21483824-5	2011	We solved the crystal structure of its complex with the human VDR-LBD and found that this natural metabolite displays specific adaptation of the ligand-binding pocket, as the 3-epimer maintains the number of hydrogen bonds by an alternative water-mediated interaction to compensate the abolished interaction with Ser278.	Hydrogen	208-216	vitamin D receptor	Homo sapiens	62-65
21238541-1	2011	This study is to examine if hydrogen-rich saline reduced amyloid-beta (Abeta) induced neural inflammation and oxidative stress in a rat model by attenuation of activation of JNK and NF-kappaB.	Hydrogen	28-36	amyloid beta precursor protein	Rattus norvegicus	71-76
21338145-6	2011	Proton hydrates are shown to coordinate 3-4 TBPs, in the form of H(3)O(+)(TBP)(3) and H(5)O(2)(+)(TBP)(4) hydrogen-bonded adducts, whereas TBPH(+) binds 1 TBP.	Hydrogen	106-114	TATA-box binding protein	Homo sapiens	44-47
21265544-5	2011	An X-ray structure of the complex between human beta-hexosaminidase B (HexB) and PYR has been determined to 2.8 A. PYR binds to the active site of HexB where several favorable van der Waals contacts and hydrogen bonds are introduced.	Hydrogen	203-211	hexosaminidase subunit beta	Homo sapiens	48-69
21265544-5	2011	An X-ray structure of the complex between human beta-hexosaminidase B (HexB) and PYR has been determined to 2.8 A. PYR binds to the active site of HexB where several favorable van der Waals contacts and hydrogen bonds are introduced.	Hydrogen	203-211	hexosaminidase subunit beta	Homo sapiens	71-75
21265544-5	2011	An X-ray structure of the complex between human beta-hexosaminidase B (HexB) and PYR has been determined to 2.8 A. PYR binds to the active site of HexB where several favorable van der Waals contacts and hydrogen bonds are introduced.	Hydrogen	203-211	hexosaminidase subunit beta	Homo sapiens	147-151
21194703-1	2011	We report on construction of hydrogen-bonded monolayers and multilayers of micelles of the poly(2-(diethylamino)ethyl methacrylate)-block-poly(N-isopropyl acrylamide) (PDEA-b-PNIPAM) with PNIPAM-corona and polybasic PDEA cores.	Hydrogen	29-37	phosphodiesterase 6A	Homo sapiens	168-172
30396116-9	2019	Compound 5 interacts with hMAO-A at four possible residues (Asn181, Gln215, Thr336, and Tyr444), while hMAO-B forms a single hydrogen bond at Glu84.	Hydrogen	125-133	monoamine oxidase B	Homo sapiens	103-109
21194703-1	2011	We report on construction of hydrogen-bonded monolayers and multilayers of micelles of the poly(2-(diethylamino)ethyl methacrylate)-block-poly(N-isopropyl acrylamide) (PDEA-b-PNIPAM) with PNIPAM-corona and polybasic PDEA cores.	Hydrogen	29-37	phosphodiesterase 6A	Homo sapiens	216-220
21194703-6	2011	By taking advantage of the high pK(a) values of TA and PEAA, we were also able to construct multilayers of PDEA-b-PNIPAM micelles through hydrogen bonding interactions between micellar PNIPAM coronas and TA or PEAA.	Hydrogen	138-146	phosphodiesterase 6A	Homo sapiens	107-111
30645109-7	2019	To test the hypothesis that specific hydrogen bonding interactions between the templating base and the incoming dNTP are a basis of this selection, we modeled the structural analogs with incoming dNTP in the Pol kappa active site.	Hydrogen	37-45	DNA polymerase lambda	Homo sapiens	208-217
21300901-9	2011	Instead, the syn 8-oxo-G template base forms the most stable replicating base pair with correct dCTP due to its small pyrimidine base size and enhanced hydrogen bonding with the Hoogsteen edge of 8-oxo-G.	Hydrogen	152-160	synemin	Homo sapiens	13-16
22778858-7	2011	Interestingly, the model predicts a hydrogen bond between E444 in transmembrane domain 8 (TM8) and Y95 in TM1 that places Y95 in a downward position, thereby removing Y95 from a direct interaction with S-citalopram.	Hydrogen	36-44	tetraspanin 16	Homo sapiens	66-88
22778858-7	2011	Interestingly, the model predicts a hydrogen bond between E444 in transmembrane domain 8 (TM8) and Y95 in TM1 that places Y95 in a downward position, thereby removing Y95 from a direct interaction with S-citalopram.	Hydrogen	36-44	tetraspanin 16	Homo sapiens	90-93
30645109-8	2019	These data indicate that the base pairing geometry and stabilization by a dense hydrogen bonding network are important molecular features for dNTP incorporation, providing a basis for understanding error-free bypass of O6-CMG by Pol kappa.	Hydrogen	80-88	DNA polymerase lambda	Homo sapiens	229-238
30669844-2	2019	The square planar S = 1/2 FeI(P4N2)+ cation (FeI+) reversibly binds H2/D2 in solution, exhibiting an inverse equilibrium isotope effect of KH2/ KD2 = 0.58(4) at -5.0  C. In the presence of excess H2, the dihydrogen complex FeI(H2)+ cleaves H2 at 25  C in a net hydrogen atom transfer reaction, producing the dihydrogen-hydride trans-FeII(H)(H2)+.	Hydrogen	68-70	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	139-142
21126103-6	2011	Second, we assembled low-fouling capsules composed of nondegradable poly(N-vinyl pyrrolidone-ran-propargyl acrylate) (PVPON(Alk)) via hydrogen bonding with poly(methacrylic acid) (PMA) and combined this with the aforementioned system (PGA(Alk)/PVPON) to produce stratified hybrid capsules.	Hydrogen	134-142	ALK receptor tyrosine kinase	Homo sapiens	124-127
21870640-2	2011	Thyroid Stimulating Hormone (TSH) which is a pituitary hormone is the main stimulator of thyroid gland to produce thyroid hormones, it binds with high affinity to the TSHR through weak bonds including hydrophobic, ionic, hydrogen bonds and trigger the initial steps in thyroid gland stimulation to produce the related hormones.	Hydrogen	221-229	thyroid stimulating hormone receptor	Homo sapiens	167-171
30669844-2	2019	The square planar S = 1/2 FeI(P4N2)+ cation (FeI+) reversibly binds H2/D2 in solution, exhibiting an inverse equilibrium isotope effect of KH2/ KD2 = 0.58(4) at -5.0  C. In the presence of excess H2, the dihydrogen complex FeI(H2)+ cleaves H2 at 25  C in a net hydrogen atom transfer reaction, producing the dihydrogen-hydride trans-FeII(H)(H2)+.	Hydrogen	206-214	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	139-142
30459217-4	2019	Structural analyses using hydrogen/deuterium exchange mass spectrometry, native electrospray ionization mass spectrometry and small-angle X-ray scattering revealed that stress-inducible Hsp70 assembles in solution as an antiparallel dimer with the intermolecular interface closely resembling the ATP-bound dimer interfaces captured in DnaK and BiP crystal structures.	Hydrogen	26-34	heat shock protein family A (Hsp70) member 4	Homo sapiens	186-191
22252425-8	2011	The tetrapeptide Boc-Val-Aib-Aib-Leu-NHMe (7) adopts an incipient 3(10)-helical conformation stabilized by three 4 1 hydrogen bonds.	Hydrogen	117-125	BOC cell adhesion associated, oncogene regulated	Homo sapiens	17-20
22252425-8	2011	The tetrapeptide Boc-Val-Aib-Aib-Leu-NHMe (7) adopts an incipient 3(10)-helical conformation stabilized by three 4 1 hydrogen bonds.	Hydrogen	117-125	ANIB1	Homo sapiens	25-28
22252425-8	2011	The tetrapeptide Boc-Val-Aib-Aib-Leu-NHMe (7) adopts an incipient 3(10)-helical conformation stabilized by three 4 1 hydrogen bonds.	Hydrogen	117-125	ANIB1	Homo sapiens	29-32
22252425-9	2011	The peptide Boc-Val-Aib-DAla-Leu-NHMe (3) adopts a novel alpha-turn conformation, stabilized by three intramolecular hydrogen bonds (two 4 1 and one 5 1).	Hydrogen	117-125	BOC cell adhesion associated, oncogene regulated	Homo sapiens	12-15
22252425-9	2011	The peptide Boc-Val-Aib-DAla-Leu-NHMe (3) adopts a novel alpha-turn conformation, stabilized by three intramolecular hydrogen bonds (two 4 1 and one 5 1).	Hydrogen	117-125	ANIB1	Homo sapiens	20-23
30597399-2	2019	Spin lattice relaxation of 1H correlated with 23Na analyzed by indirect observation using polarization transfer from 1H nuclei to 23Na nuclei showed that the Na+ cations are well hydrated in the cellulose nanocrystal films.	Hydrogen	27-29	spindlin 1	Homo sapiens	0-4
30597399-2	2019	Spin lattice relaxation of 1H correlated with 23Na analyzed by indirect observation using polarization transfer from 1H nuclei to 23Na nuclei showed that the Na+ cations are well hydrated in the cellulose nanocrystal films.	Hydrogen	117-119	spindlin 1	Homo sapiens	0-4
21678774-1	2011	Recent STM experiments show that by exposing h-BN/Rh(111) nanomesh to water or atomic hydrogen interesting phenomena can be observed.	Hydrogen	86-94	sulfotransferase family 1A member 3	Homo sapiens	7-10
30886796-0	2019	Synthesis of a MoS x -O-PtO x Electrocatalyst with High Hydrogen Evolution Activity Using a Sacrificial Counter-Electrode.	Hydrogen	56-64	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	15-18
30886796-3	2019	The theory calculations and experimental results confirm the high hydrogen evolution activity that is likely due to the fact that the S atoms in MoS x can be substituted with O atoms during a potential cycling process when using Pt as a counter-electrode, where the O atoms act as bridges between the catalytic PtO x particles and the MoS x support to generate a MoS x -O-PtO x structure, allowing the Pt atoms to donate more electrons thus facilitating the hydrogen evolution reaction process.	Hydrogen	66-74	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	145-148
21146880-4	2011	Here we found that the expression of miR-15a was up-regulated in the presence of high glucose for 1h, whereas prolonged periods of high glucose exposure resulted in depressed expression of miR-15a, and the change in expression levels of miR-15a coincided with insulin biosynthesis.	Hydrogen	98-100	microRNA 15a	Mus musculus	37-44
30886796-3	2019	The theory calculations and experimental results confirm the high hydrogen evolution activity that is likely due to the fact that the S atoms in MoS x can be substituted with O atoms during a potential cycling process when using Pt as a counter-electrode, where the O atoms act as bridges between the catalytic PtO x particles and the MoS x support to generate a MoS x -O-PtO x structure, allowing the Pt atoms to donate more electrons thus facilitating the hydrogen evolution reaction process.	Hydrogen	66-74	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	335-338
30886796-3	2019	The theory calculations and experimental results confirm the high hydrogen evolution activity that is likely due to the fact that the S atoms in MoS x can be substituted with O atoms during a potential cycling process when using Pt as a counter-electrode, where the O atoms act as bridges between the catalytic PtO x particles and the MoS x support to generate a MoS x -O-PtO x structure, allowing the Pt atoms to donate more electrons thus facilitating the hydrogen evolution reaction process.	Hydrogen	66-74	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	335-338
30886796-3	2019	The theory calculations and experimental results confirm the high hydrogen evolution activity that is likely due to the fact that the S atoms in MoS x can be substituted with O atoms during a potential cycling process when using Pt as a counter-electrode, where the O atoms act as bridges between the catalytic PtO x particles and the MoS x support to generate a MoS x -O-PtO x structure, allowing the Pt atoms to donate more electrons thus facilitating the hydrogen evolution reaction process.	Hydrogen	458-466	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	145-148
30577438-6	2018	1H-NMR-based metabolomics and mass spectrometry-based proteomics were utilized to characterize the metabolites and proteins induced by SpD in a human cardiomyocyte cell line (AC16) and human breast cancer cell line (MCF-7).	Hydrogen	0-2	surfactant protein D	Homo sapiens	135-138
21695637-4	2011	However, the structure of PDE4D2 in complex with cAMP shows that Gln369 forms only one hydrogen bond with the substrate.	Hydrogen	87-95	phosphodiesterase 4D	Homo sapiens	26-31
30406794-0	2018	Carbon-encapsulated multi-phase nanocomposite of W2C@WC1-x as a highly active and stable electrocatalyst for hydrogen generation.	Hydrogen	109-117	ATPase copper transporting beta	Homo sapiens	53-56
21093476-3	2011	The structure of HEC-g-PCL copolymers was characterized by FTIR and 1H NMR.	Hydrogen	68-70	PHD finger protein 1	Homo sapiens	23-26
30406794-2	2018	Herein, multiphase nanocomposites of W2C@WC1-x encapsulated within graphitic carbon layers were prepared via a facile and effective process of electrical explosion of wires and subsequent heat treatment to serve as a highly active and stable electrocatalyst without any noble metal for hydrogen generation.	Hydrogen	286-294	ATPase copper transporting beta	Homo sapiens	41-44
30421613-6	2018	Compound 2b exhibited a spin isomerism behavior ( S = 0   S = 1) as determined by variable-temperature 1H NMR experiments (Delta H  = 7.7 kcal mol-1), being also supported by computational studies (Delta E = 4.2 kcal mol-1).	Hydrogen	103-105	spindlin 1	Homo sapiens	24-28
22187667-8	2011	Next to Cl(-) ion is a hydrogen bonded water molecule W-7" which in turn is hydrogen bonded to W-8" and N atom of SCN(-).	Hydrogen	23-31	sorcin	Homo sapiens	114-117
22187667-8	2011	Next to Cl(-) ion is a hydrogen bonded water molecule W-7" which in turn is hydrogen bonded to W-8" and N atom of SCN(-).	Hydrogen	76-84	sorcin	Homo sapiens	114-117
21731699-4	2011	Our data indicate that the SRA binding pocket can accommodate 5hmC and stabilizes the flipped base by hydrogen bond formation with the hydroxyl group.	Hydrogen	102-110	steroid receptor RNA activator 1	Homo sapiens	27-30
30973277-8	2018	The Gene Ontology and KEGG enrichment analyses identified a large number of proteins and biological processes that may responsible for the protective effect of hydrogen, including VEGFA, PDGFB, IGFBP3, EDN1, NADPH oxidase, the coagulation cascade, etc.	Hydrogen	160-168	platelet derived growth factor subunit B	Homo sapiens	187-192
30973277-9	2018	Conclusions: Molecular hydrogen protects AECIIs from hyperoxic injury by complex mechanisms involving a variety of proteins and biological processes, such as VEGFA, PDGFB, IGFBP3, EDN1, NADPH oxidase and the coagulation cascade.	Hydrogen	23-31	platelet derived growth factor subunit B	Homo sapiens	165-170
29729938-0	2018	Solute carrier family 9, subfamily A, member 3 (SLC9A3)/sodium-hydrogen exchanger member 3 (NHE3) dysregulation and dilated intercellular spaces in patients with eosinophilic esophagitis.	Hydrogen	63-71	solute carrier family 9 member A3	Homo sapiens	92-96
22491306-7	2010	The modeled structure of CYP2C19 showed that the hydrogen bond between the main chain oxygen of Ile207 and the side chain Ogamma of Thr210 would be lost when Thr210 was substituted by Asn; however, no steric constraint was observed, although Asn is larger than Thr in size.	Hydrogen	49-57	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	25-32
20696268-4	2010	The favored glycosidic syn-conformation exposes the Hoogsteen edge of the base for hydrogen bonding with adenine during DNA synthesis.	Hydrogen	83-91	synemin	Homo sapiens	23-26
30155694-5	2018	Docking palmatine to the crystal structure of human beta2-AR (PDB 5X7D) suggested that the ligand forms a hydrogen bond with N312 and hydrophobic interaction with several amino acid residues in the binding pocket, such as D113 and V114.	Hydrogen	106-114	adrenoceptor beta 2	Homo sapiens	52-60
30607149-4	2018	Based on the results, the compounds L1, L2, L4, L5, L6, L7, L10, L15, and L18 may be promising EGFR inhibitors based on docking score and hydrogen bonds.	Hydrogen	138-146	immunoglobulin kappa variable 1-13	Homo sapiens	74-77
21043511-0	2010	Evidence for substrate preorganization in the peptidylglycine alpha-amidating monooxygenase reaction describing the contribution of ground state structure to hydrogen tunneling.	Hydrogen	158-166	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	46-91
30486822-5	2018	1H-NMR metabolite profiling was used to identify metabolic changes in ALDH7A1-depleted cells.	Hydrogen	0-2	aldehyde dehydrogenase 7 family member A1	Homo sapiens	70-77
20572637-2	2010	It is found that HD relaxes more slowly than H(2) in both environments and at all temperatures, as expected from the smaller values of the spin-rotation and dipole-dipole coupling in HD compared to H(2).	Hydrogen	45-49	spindlin 1	Homo sapiens	139-143
30303292-3	2018	The applicability of this unique catalyst is demonstrated by employing it in a fuel cell running on H2 /CO and O2 /H2 O2 .	Hydrogen	100-102	immunoglobulin kappa variable 1D-39	Homo sapiens	104-120
21036084-5	2010	The ADP-ribose phosphate unit showed the highest degree of stabilization through hydrogen bond interactions with the nsP3 V33 residue and the consequent amino acid residues 110-114.	Hydrogen	81-89	SH2 domain containing 3C	Homo sapiens	117-121
31458196-6	2018	Both the forms (TPS and TPR) were thoroughly characterized by powder diffraction X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, and 1H NMR and were identified to be two different crystalline forms.	Hydrogen	208-210	translocated promoter region, nuclear basket protein	Homo sapiens	24-27
20937909-7	2010	This analysis explains how SND1 preferentially recognizes symmetrical dimethylarginine via an aromatic cage and conserved hydrogen bonds, and provides a general paradigm for the binding mechanisms of methylarginine-containing peptides by extended Tudor domains.	Hydrogen	122-130	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	27-31
30413709-4	2018	The structure of the endothelin-3-bound receptor reveals that the disruption of water-mediated interactions between W6.48 and D2.50 is critical for receptor activation, while these hydrogen-bonding interactions are partially preserved in the IRL1620-bound structure.	Hydrogen	181-189	endothelin 3	Homo sapiens	21-33
20843694-5	2010	Although docking experiments to a homology model of MAG revealed that mimic 3 forms all but one of the essential hydrogen bonds identified for the earlier reported lead 2, its affinity was substantially reduced.	Hydrogen	113-121	myelin associated glycoprotein	Homo sapiens	52-55
20717572-1	2010	A series of Fourier transform infrared spectra (FTIR) of the hydrogen bonded complexes (CH(2))(2)O-HF and -DF have been recorded in the 50-750 cm(-1) range up to 0.1 cm(-1) resolution in a static cell maintained at near room temperature.	Hydrogen	61-69	TNF superfamily member 11	Homo sapiens	97-109
30303501-1	2018	para-Hydrogen (p-H2) induced polarisation (PHIP) is an increasingly popular method for sensitivity enhancement in NMR spectroscopy.	Hydrogen	0-13	polyhomeotic homolog 2	Homo sapiens	15-19
30303501-5	2018	A linear relationship was found between p-H2 enrichment and analyte 1H hyperpolarisation for a range of molecules, polarisation transfer catalysts, NMR detection fields and for both the SABRE and SABRE-Relay transfer mechanisms over the range 29-99% p-H2 purity.	Hydrogen	68-70	polyhomeotic homolog 2	Homo sapiens	40-44
30303501-5	2018	A linear relationship was found between p-H2 enrichment and analyte 1H hyperpolarisation for a range of molecules, polarisation transfer catalysts, NMR detection fields and for both the SABRE and SABRE-Relay transfer mechanisms over the range 29-99% p-H2 purity.	Hydrogen	68-70	polyhomeotic homolog 2	Homo sapiens	250-254
30519264-6	2018	Finally, molecular docking result showed SE1 interacts with TYR245 and HIS226 of MMP-9 by hydrogen bond and Pi-Pi bond to suppress MMP-9 activity.	Hydrogen	90-98	matrix metallopeptidase 9	Homo sapiens	81-86
20843096-7	2010	Molecular dynamics (MD) simulations and density functional theory (DFT) calculations revealed that thermal treatment could significantly alter the electronic characteristics and the intramolecular electron transfer ability of FAD (flavin adenine dinucleotide), and hydrogen bond networks formed between FAD and the amino acid residues around the cofactor, leading to the change of the secondary structure and the catalytic activity of GOx.	Hydrogen	265-273	hydroxyacid oxidase 1	Homo sapiens	435-438
20443086-0	2010	1H, 13C and 15N NMR assignments of RNA recognizing motifs 1 and 2 of BRUNOL-3 protein from human involved in myotonic dystrophy.	Hydrogen	0-2	CUGBP Elav-like family member 2	Homo sapiens	69-77
20503119-0	2010	1H, 15N, and 13C chemical shift assignments of calcium-binding protein 1 with Ca2+ bound at EF1, EF3 and EF4.	Hydrogen	0-2	GTP binding elongation factor GUF1	Homo sapiens	105-108
29958907-0	2018	Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway.	Hydrogen	0-8	PTEN induced kinase 1	Rattus norvegicus	158-163
20501796-0	2010	Voltage-dependent charge movement associated with activation of the CLC-5 2Cl-/1H+ exchanger.	Hydrogen	79-81	chloride voltage-gated channel 5	Homo sapiens	68-73
29958907-13	2018	Taken together, our findings demonstrated H2 had a neuroprotective effect on OGD/R damaged neurons by protecting mitochondrial function and the potential protection mechanism may closely related to enhancement of mitophagy mediated by PINK1/Parkin signaling pathway.	Hydrogen	42-44	PTEN induced kinase 1	Rattus norvegicus	235-240
20726545-7	2010	The mechanism revealed here is consistent with the previous study on secondary structure of beta-hairpin polypeptide, GB1, PEPTIDE 1, and TRPZIP4, suggesting that there is a general mechanism in the denaturation of protein backbone hydrogen bonds by urea.	Hydrogen	232-240	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	118-121
30031366-15	2018	Notably, the hydrogen yields rates of polymeric carbon nitride foam were 352.2, 299.8, 184.9 and 94.3 mumol/g/h in natural seawater, pharmaceutical wastewater, water from reservoir and tap water, respectively.	Hydrogen	13-21	nuclear RNA export factor 1	Homo sapiens	185-188
20573803-4	2010	In this study, we provide direct evidence that HRG can function cooperatively with cell surface HS on the monocytic cell line THP-1 to promote necrotic cell removal.	Hydrogen	96-98	histidine rich glycoprotein	Homo sapiens	47-50
30380790-4	2018	During this zigzag maneuver, the pressure of gaseous hydrogen (GH2) in the small LH2 tank increased to roughly 0.67 MPaG/h, and the temperature of the GH2 in the small LH2 tank increased at the position of gaseous hydrogen at roughly 1.0 K/min when the maximum rolling angle was 5 ; the average rolling and liquid-oscillation periods were 114 and 118 s, respectively, as detected by the MgB2 level sensors, which therefore detected a long-period LH2 wave due to the ship"s motion.	Hydrogen	53-61	growth hormone 2	Homo sapiens	63-66
20936717-7	2010	CONCLUSION: Hydrogen gas inhalation can decrease the serum HMGB1 levels and increase the survival rate of rats with severe sepsis.	Hydrogen	12-20	high mobility group box 1	Rattus norvegicus	59-64
20441802-0	2010	Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivo.	Hydrogen	7-15	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	Mus musculus	26-30
20441802-9	2010	Taken together, we show that NHA2 is a RANKL-induced plasmalemmal sodium/hydrogen exchanger in osteoclasts.	Hydrogen	73-81	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	Mus musculus	29-33
30380790-4	2018	During this zigzag maneuver, the pressure of gaseous hydrogen (GH2) in the small LH2 tank increased to roughly 0.67 MPaG/h, and the temperature of the GH2 in the small LH2 tank increased at the position of gaseous hydrogen at roughly 1.0 K/min when the maximum rolling angle was 5 ; the average rolling and liquid-oscillation periods were 114 and 118 s, respectively, as detected by the MgB2 level sensors, which therefore detected a long-period LH2 wave due to the ship"s motion.	Hydrogen	214-222	growth hormone 2	Homo sapiens	151-154
29888540-1	2018	While pristine [TaO2 ]+ is rather inert in its thermal reactions with both methane and molecular hydrogen, the cluster oxide becomes reactive upon ligation with the closed-shell ligand CO2 .	Hydrogen	97-105	TAO kinase 2	Homo sapiens	16-20
30092978-3	2018	CNC-g-PAM acted as both interfacial compatible nanofillers and physical crosslinkers through reversible hydrogen bonds between PAA and PAM on the surface of CNC.	Hydrogen	104-112	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	6-9
20649595-0	2010	The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4.	Hydrogen	148-156	glucagon	Rattus norvegicus	35-58
20649595-0	2010	The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4.	Hydrogen	148-156	glucagon	Rattus norvegicus	92-115
20649595-11	2010	A hydrogen bond between Ser32 of Ex4 and Asp-68 of rGLP-1R, which is not formed with Glu-68 of hGLP-1R, is responsible for the improved affinity of Ex4 at the rat receptor.	Hydrogen	2-10	glucagon-like peptide 1 receptor	Rattus norvegicus	51-58
30092978-3	2018	CNC-g-PAM acted as both interfacial compatible nanofillers and physical crosslinkers through reversible hydrogen bonds between PAA and PAM on the surface of CNC.	Hydrogen	104-112	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	135-138
30239565-2	2018	Objective: We hypothesized that individuals with higher AMY1 CN would digest starchy foods faster and show higher postprandial responses and lower breath hydrogen excretion compared with those with low CN.	Hydrogen	154-162	amylase alpha 1A	Homo sapiens	56-60
20127742-6	2010	Here we present a modification of the DFT method that keeps the critical aspects of the larger basis set (B3LYP/6-31+G*) while allowing the less-essential atom interactions to be calculated using a smaller basis set, thus allowing for faster completion without sacrificing the interactions dictating the hydrogen bonding networks in alpha-maltose.	Hydrogen	304-312	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	108-111
29569106-1	2018	We report the nearly complete 1H, 15N and 13C resonance assignment and the solution structure of the external DII domain of the yeast Rvb2 protein, a member of the AAA+ATPase superfamily.	Hydrogen	30-32	RuvB family ATP-dependent DNA helicase reptin	Saccharomyces cerevisiae S288C	134-138
29594928-0	2018	1H, 13C and 15N resonance assignments for a chemokine receptor-binding domain of FROUNT, a cytoplasmic regulator of chemotaxis.	Hydrogen	0-2	nucleoporin 85	Homo sapiens	81-87
20464001-0	2010	Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism.	Hydrogen	76-84	monoglyceride lipase	Homo sapiens	107-130
20464001-0	2010	Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism.	Hydrogen	76-84	monoglyceride lipase	Homo sapiens	132-136
29594929-0	2018	1H, 13C and 15N backbone NMR chemical shift assignments of the C-terminal P4 domain of Ahnak.	Hydrogen	0-2	AHNAK nucleoprotein	Homo sapiens	87-92
20464001-0	2010	Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism.	Hydrogen	76-84	monoglyceride lipase	Homo sapiens	156-160
30119179-0	2018	Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived mesenchymal stem cells in vivo.	Hydrogen	0-8	KRAS proto-oncogene, GTPase	Rattus norvegicus	66-69
20464001-6	2010	hMGL inhibition by AM6701 alters this hydrogen-bonding pattern through subtle active-site structural rearrangements without influencing hydrogen-bond occupancies.	Hydrogen	38-46	monoglyceride lipase	Homo sapiens	0-4
20464001-8	2010	In contrast, hMGL titration with NAM, which leads to cysteine alkylation, stoichiometrically decreases the population of the active-site hydrogen bonds.	Hydrogen	137-145	monoglyceride lipase	Homo sapiens	13-17
30119179-10	2018	And the underlying mechanism of antisenescence effects of hydrogen in BMSCs was via the ROS/p53/p21 signaling pathway.	Hydrogen	58-66	KRAS proto-oncogene, GTPase	Rattus norvegicus	96-99
20464001-10	2010	These data provide detailed molecular insight into the distinctive mechanisms of two covalent hMGL inhibitors and implicate a hydrogen-bond network as a structural feature of hMGL catalytic function.	Hydrogen	126-134	monoglyceride lipase	Homo sapiens	94-98
20464001-10	2010	These data provide detailed molecular insight into the distinctive mechanisms of two covalent hMGL inhibitors and implicate a hydrogen-bond network as a structural feature of hMGL catalytic function.	Hydrogen	126-134	monoglyceride lipase	Homo sapiens	175-179
30219992-0	2018	The effect of H3O+ on the membrane morphology and hydrogen bonding of a phospholipid bilayer.	Hydrogen	50-58	H3 clustered histone 15	Homo sapiens	14-17
20583790-4	2010	The peptide nitrogen of conserved residues PsaA-Leu722 and PsaB-Leu706 is involved in asymmetric hydrogen-bonding to PhQ(A) and PhQ(B), respectively.	Hydrogen	97-105	photosystem I P700 chlorophyll a apoprotein A2	Chlamydomonas reinhardtii	59-63
30219992-6	2018	We proposed that increasing the concentraton of H3O+ resulted in stronger hydrogen bonding between the phosphate oxygens at the water-lipid interface leading to a reduced area per lipid and slightly increased membrane thickness.	Hydrogen	74-82	H3 clustered histone 15	Homo sapiens	48-51
30219992-10	2018	Another significant finding was that the hydrogen bonds formed by H3O+ ions with lipid headgroup oxygens are, on average, shorter in length and longer-lived than the ones formed in bulk water.	Hydrogen	41-49	H3 clustered histone 15	Homo sapiens	66-69
30219992-12	2018	In summary, the MD simulations support a model where the hydrogen bonding capacity of H3O+ for carbonyl and phosphate oxygens is the origin of the pH-induced changes in lipid packing in phospholipid membranes.	Hydrogen	57-65	H3 clustered histone 15	Homo sapiens	86-89
30350551-0	2018	Sub-1.5 nm Ultrathin CoP Nanosheet Aerogel: Efficient Electrocatalyst for Hydrogen Evolution Reaction at All pH Values.	Hydrogen	74-82	Rho guanine nucleotide exchange factor 1	Homo sapiens	0-7
20540525-17	2010	The reactions are second order (k(obs) = k(anti&lt;--&gt;syn)[H(2)]) and do not involve H(2)/IrH hydrogen atom scrambling.	Hydrogen	62-66	synemin	Homo sapiens	57-60
30133282-5	2018	The water molecule is in hydrogen bonding with the nearby anionic Glu111 of IDE but not directly bound to the catalytic Zn ion.	Hydrogen	25-33	insulin degrading enzyme	Homo sapiens	76-79
30004596-0	2018	SrP3 N5 NH: A Framework-Type Imidonitridophosphate Featuring Structure-Directing Hydrogen Bonds.	Hydrogen	81-89	karyopherin subunit alpha 4	Homo sapiens	0-4
20430871-7	2010	Inhibition of the sodium/hydrogen exchanger 3 (NHE3) had an additive effect to AICAR, suggesting that the AMPK effect is not via NHE3.	Hydrogen	25-33	solute carrier family 9 member A3	Homo sapiens	47-51
20590202-3	2010	Electrons were found trapped near an o-D(2) or an HD in solid p-H(2) due to the long-range charge-induced dipole and quadrupole interactions between electrons and isotopic hydrogen molecules.	Hydrogen	172-180	relaxin 2	Homo sapiens	64-68
30293367-23	2018	Compared with those in burn group, the protein expressions of HMGB1 of rats in hydrogen-rich saline group at PIH 6, 24, and 72 were significantly decreased (P&lt;0.05).	Hydrogen	79-87	high mobility group box 1	Rattus norvegicus	62-67
20395291-2	2010	Molecular dynamics simulations showed that, although the fewer water molecules in rhodopsin were relatively movable, the hydrogen bond network of the beta2-adrenergic receptor was fully loaded with water molecules that were surprisingly immobilized between the two rotamer switches, both apparently being in their closed conformation.	Hydrogen	121-129	adrenoceptor beta 2	Homo sapiens	150-175
20395291-5	2010	Mutational analysis of the beta2-adrenergic receptor demonstrated that the highly conserved polar residues of the hydrogen bond network were all important for receptor signaling but served different functions, some dampening constitutive activity (AsnI:18, AspII:10, and AsnVII:13), whereas others (AsnVII:12 and AsnVII:16) located one helical turn apart and sharing a water molecule were shown to be essential for agonist-induced signaling.	Hydrogen	114-122	adrenoceptor beta 2	Homo sapiens	27-52
29944853-7	2018	We also characterize the differences in phi/psi angles, sequence, and hydrogen bonding between OMP extracellular loops and OMP periplasmic turns.	Hydrogen	70-78	olfactory marker protein	Homo sapiens	95-98
20219227-5	2010	These data demonstrate that infection results in changes to the epithelial ultrastructure, rearrangement of F-actin, decreased absorption of sodium, as well as redistribution of the sodium/hydrogen exchanger 3 (NHE3) from the membrane to the cytoplasm.	Hydrogen	189-197	solute carrier family 9 member A3	Homo sapiens	211-215
29944853-7	2018	We also characterize the differences in phi/psi angles, sequence, and hydrogen bonding between OMP extracellular loops and OMP periplasmic turns.	Hydrogen	70-78	olfactory marker protein	Homo sapiens	123-126
29944853-11	2018	Finally, in all OMP tight turns, hydrogen bonding between the side chain and backbone 2 to 4 residues away from that side chain plays an important role.	Hydrogen	33-41	olfactory marker protein	Homo sapiens	16-19
29028768-0	2018	Hydrogen Gas Treatment Improves the Neurological Outcome After Traumatic Brain Injury Via Increasing miR-21 Expression.	Hydrogen	0-8	microRNA 21	Rattus norvegicus	101-107
20378544-6	2010	Using complete backbone resonance assignments, chemical shift perturbations analysis, and hydrogen/deuterium exchange experiments, we conclusively show that VAMP7 adopts a preferentially closed conformation in solution.	Hydrogen	90-98	vesicle associated membrane protein 7	Homo sapiens	157-162
20147652-4	2010	Coexpression of KLHL1 with Ca(V)3.1 or Ca(V)3.2 (alpha(1G) or alpha(1H) subunits) caused increases in T-type current density (35%) and calcium influx (75-83%) when carried out by alpha(1H) but not by alpha(1G).	Hydrogen	68-70	kelch like family member 1	Homo sapiens	16-21
20147652-4	2010	Coexpression of KLHL1 with Ca(V)3.1 or Ca(V)3.2 (alpha(1G) or alpha(1H) subunits) caused increases in T-type current density (35%) and calcium influx (75-83%) when carried out by alpha(1H) but not by alpha(1G).	Hydrogen	185-187	kelch like family member 1	Homo sapiens	16-21
20147652-7	2010	KLHL1 also induced an increase in alpha(1H) current deactivation time (tau(deactivation)).	Hydrogen	40-42	kelch like family member 1	Homo sapiens	0-5
20147652-8	2010	Interestingly, the majority of KLHL1"s effects were eliminated when the actin-binding motif (kelch) was removed, with the exception of the calcium influx increase during action potentials, indicating that KLHL1 interacts with alpha(1H) and actin and selectively regulates alpha(1H) function by increasing the number of alpha(1H) channels.	Hydrogen	232-234	kelch like family member 1	Homo sapiens	31-36
20147652-8	2010	Interestingly, the majority of KLHL1"s effects were eliminated when the actin-binding motif (kelch) was removed, with the exception of the calcium influx increase during action potentials, indicating that KLHL1 interacts with alpha(1H) and actin and selectively regulates alpha(1H) function by increasing the number of alpha(1H) channels.	Hydrogen	232-234	kelch like family member 1	Homo sapiens	205-210
20147652-8	2010	Interestingly, the majority of KLHL1"s effects were eliminated when the actin-binding motif (kelch) was removed, with the exception of the calcium influx increase during action potentials, indicating that KLHL1 interacts with alpha(1H) and actin and selectively regulates alpha(1H) function by increasing the number of alpha(1H) channels.	Hydrogen	278-280	kelch like family member 1	Homo sapiens	31-36
20147652-8	2010	Interestingly, the majority of KLHL1"s effects were eliminated when the actin-binding motif (kelch) was removed, with the exception of the calcium influx increase during action potentials, indicating that KLHL1 interacts with alpha(1H) and actin and selectively regulates alpha(1H) function by increasing the number of alpha(1H) channels.	Hydrogen	278-280	kelch like family member 1	Homo sapiens	205-210
20184928-5	2010	In vitro RFP expressing B16F10 tumor cell (RFP/B16F10) culture system, the siRNA-GC-PEI NPs presented a rapid time-dependent cellular uptake profile within 1h.	Hydrogen	156-158	tripartite motif-containing 27	Mus musculus	9-12
20184928-5	2010	In vitro RFP expressing B16F10 tumor cell (RFP/B16F10) culture system, the siRNA-GC-PEI NPs presented a rapid time-dependent cellular uptake profile within 1h.	Hydrogen	156-158	tripartite motif-containing 27	Mus musculus	43-46
20004922-2	2010	COX-1 activity was determined by measuring serum thromboxane (Tx)B(2) synthesis in blood samples allowed to clot at 37 degrees C for 1h.	Hydrogen	133-135	cytochrome c oxidase subunit I	Canis lupus familiaris	0-5
20380468-5	2010	The remaining fragments of both the substrates were found to interact with IDE through several hydrogen bonding, pi-pi, CH-pi, and NH-pi interactions.	Hydrogen	95-103	insulin degrading enzyme	Homo sapiens	75-78
20380468-6	2010	In comparison to Abeta40, Abeta42 is more flexible and interacts through a smaller number (17-22) of hydrogen bonds in the catalytic chamber of IDE.	Hydrogen	101-109	insulin degrading enzyme	Homo sapiens	144-147
20225831-6	2010	In both series the aqua ligands are hydrogen bonded to the nitrogen atoms from both the terminal CN(-) groups and the hmt molecules.	Hydrogen	36-44	histamine N-methyltransferase	Homo sapiens	118-121
20203411-2	2010	A single unique N-H...N hydrogen bond links the molecules into two symmetry-related sets of C(11) chains running parallel to the [011] and [011] directions, respectively, and these two sets of chains are linked into a continuous three-dimensional framework structure by a single unique C-H...N hydrogen bond which forms a chain parallel to the [100] direction.	Hydrogen	24-32	RNA polymerase III subunit K	Homo sapiens	92-97
20203411-2	2010	A single unique N-H...N hydrogen bond links the molecules into two symmetry-related sets of C(11) chains running parallel to the [011] and [011] directions, respectively, and these two sets of chains are linked into a continuous three-dimensional framework structure by a single unique C-H...N hydrogen bond which forms a chain parallel to the [100] direction.	Hydrogen	294-302	RNA polymerase III subunit K	Homo sapiens	92-97
19669810-9	2010	Furthermore, two hydrogen bonds were predicted in both complexes PB1-F2/VDAC1 and PB1-F2/ANT3.	Hydrogen	17-25	polybromo 1	Homo sapiens	65-68
19669810-9	2010	Furthermore, two hydrogen bonds were predicted in both complexes PB1-F2/VDAC1 and PB1-F2/ANT3.	Hydrogen	17-25	polybromo 1	Homo sapiens	82-85
20032459-9	2010	Unlike Ala substitutions, the Cys-to-Ser mutation in MBD2 preserves the conformation and reduced state of N-ATP7B, suggesting that hydrogen bonds contribute to interdomain communications.	Hydrogen	131-139	ATPase copper transporting beta	Homo sapiens	106-113
19902960-2	2010	One of the early triumphs of quantum mechanics was Heisenberg"s prediction, based on the Pauli principle and wave function symmetry arguments, that the simplest molecule, H(2), should exist as two distinct species-allotropes of elemental hydrogen.	Hydrogen	238-246	relaxin 2	Homo sapiens	171-175
19916533-5	2010	A submolecular resolution STM image of these domains exhibits distinction between some functional groups and the surrounding intermolecular hydrogen bonds along the [130] or [310] direction.	Hydrogen	140-148	sulfotransferase family 1A member 3	Homo sapiens	26-29
19916533-6	2010	In the submolecular resolution STM, it is most reasonably interpreted that intermolecular network between adsorption alanines is connected by N-H(1)...O(2) and N-H(2)...O(2) hydrogen bonds to form each homochiral domain and the bond at the domain boundary is enhanced by scanning tip which is most probably modified.	Hydrogen	174-182	sulfotransferase family 1A member 3	Homo sapiens	31-34
20029922-10	2010	Eventually, disc 2, functionalized with a hydrogen-bonding acceptor moiety, might perform secondary interactions with molecules such as acids.	Hydrogen	42-50	disrupted in schizophrenia 2	Homo sapiens	12-18
20136329-5	2010	The spin filter effect of MnPc is very robust regardless of whether the open ends of the SWCNT electrodes are terminated by hydrogen, fluorine, or carbon dimers, demonstrating its promising applications in future molecular spintronics.	Hydrogen	124-132	spindlin 1	Homo sapiens	4-8
19551886-1	2010	In the present work, we have found by an atomistic molecular dynamics simulation that hydrogen atoms originating from the residues of a prokaryotic ClC protein (EcClC) stabilize the chloride ion without water molecules in the pore of ClC protein.	Hydrogen	86-94	Charcot-Leyden crystal galectin	Homo sapiens	163-166
19998390-2	2010	The contour plot of the gCOSY spectrum of 1-10 revealed cross peaks arising from the five-bond coupling between the H2 and H5 resonances of the dihydropyrazine ring for syn- ((5)J(H2, H5) = 4-5.7 Hz) and for anti-isomers ((5)J(H2, H5) = 3.4-3.8 Hz).	Hydrogen	116-118	synemin	Homo sapiens	169-172
19998390-2	2010	The contour plot of the gCOSY spectrum of 1-10 revealed cross peaks arising from the five-bond coupling between the H2 and H5 resonances of the dihydropyrazine ring for syn- ((5)J(H2, H5) = 4-5.7 Hz) and for anti-isomers ((5)J(H2, H5) = 3.4-3.8 Hz).	Hydrogen	180-182	synemin	Homo sapiens	169-172
19998390-2	2010	The contour plot of the gCOSY spectrum of 1-10 revealed cross peaks arising from the five-bond coupling between the H2 and H5 resonances of the dihydropyrazine ring for syn- ((5)J(H2, H5) = 4-5.7 Hz) and for anti-isomers ((5)J(H2, H5) = 3.4-3.8 Hz).	Hydrogen	180-182	synemin	Homo sapiens	169-172
29028768-4	2018	In the present study, we investigated whether H2 treatment could improve the neurological outcome after TBI via increasing miR-21 expression.	Hydrogen	46-48	microRNA 21	Rattus norvegicus	123-129
29028768-7	2018	Here, we found that H2 treatment significantly increased the expression of miR-21 in brain from 6 h to 3 d after TBI.	Hydrogen	20-22	microRNA 21	Rattus norvegicus	75-81
29028768-8	2018	The level of miR-21 expression in brain was significantly decreased after intracerebroventricular infusion of miR-21 antagomir in TBI-challenged rats with or without H2 treatment.	Hydrogen	166-168	microRNA 21	Rattus norvegicus	13-19
29028768-9	2018	Moreover, we found that H2 treatment conferred a better neurological outcome after TBI by improving neurological dysfunction, alleviating brain edema as well as decreasing lesion volume and blood-brain barrier permeability, which were significantly prevented by miR-21 antagomir.	Hydrogen	24-26	microRNA 21	Rattus norvegicus	262-268
29028768-11	2018	In addition, H2 treatment decreased the levels of oxidative products (malondialdehyde and 8-iso-prostaglandin F2alpha) and increased the activities of endogenous antioxidant enzymes (superoxide dismutase and catalase) in brain after TBI, which were prevented by miR-21 antagomir.	Hydrogen	13-15	microRNA 21	Rattus norvegicus	262-268
29028768-12	2018	Taken together, these data indicate that H2 treatment improves the neurological outcome after TBI via increasing miR-21 expression.	Hydrogen	41-43	microRNA 21	Rattus norvegicus	113-119
30211152-1	2018	Tin oxide SnO2-based gas sensors have been widely used for detecting typical fault characteristic gases extracted from power transformer oil, namely, H2, CO, CO2, CH4, C2H2, C2H4, and C2H6, due to the remarkable advantages of high sensitivity, fast response, long-term stability, and so on.	Hydrogen	150-152	strawberry notch homolog 2	Homo sapiens	10-13
30158152-3	2018	Tenapanor, a minimally absorbed, small-molecule inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3), acts locally in the gastrointestinal tract to inhibit sodium absorption.	Hydrogen	72-80	solute carrier family 9 member A3	Homo sapiens	102-106
30043614-5	2018	The CNF-PPy complexes not only tangle with PVA chains though hydrogen bonds, but also form reversibly cross-linked complexes with borate ions.	Hydrogen	61-69	NPHS1 adhesion molecule, nephrin	Homo sapiens	4-7
29920974-4	2018	A significant elevation in the photocatalytic hydrogen evolution rate is achieved with a maximal value of 3.02 mmol g-1  h-1 during the first 3 h, which is almost 76-fold higher than that of P25 and comparable to that of Pt-P25.	Hydrogen	46-54	tubulin polymerization promoting protein	Homo sapiens	191-194
29920974-4	2018	A significant elevation in the photocatalytic hydrogen evolution rate is achieved with a maximal value of 3.02 mmol g-1  h-1 during the first 3 h, which is almost 76-fold higher than that of P25 and comparable to that of Pt-P25.	Hydrogen	46-54	tubulin polymerization promoting protein	Homo sapiens	224-227
30174556-3	2018	The distribution ratio of H2 electron donor for nitrate and sulfate was 70.0 : 26.9 at the high influent loading ratio of sulfate/nitrate of 853.3 g SO42-/m3 d : 140.5 g N/m3 d, which indicated that denitrification bacteria (DB) were normally dominated to complete H2 electron with sulfate bacteria (SRB).	Hydrogen	26-28	chaperonin containing TCP1 subunit 4	Homo sapiens	300-303
29933522-3	2018	In contrast with traditional antioxidants, substituting hydrogen with deuterium at bis-allylic sites in polyunsaturated fatty acids (D-PUFA) decreases the rate-limiting initiation step of PUFA autoxidation, a strategy that has shown benefits in other neurodegenerative diseases.	Hydrogen	56-64	pumilio RNA binding family member 3	Homo sapiens	135-139
29933522-3	2018	In contrast with traditional antioxidants, substituting hydrogen with deuterium at bis-allylic sites in polyunsaturated fatty acids (D-PUFA) decreases the rate-limiting initiation step of PUFA autoxidation, a strategy that has shown benefits in other neurodegenerative diseases.	Hydrogen	56-64	pumilio RNA binding family member 3	Homo sapiens	188-192
29939736-2	2018	These low-spin Fe3+ complexes produce moderately paramagnetically shifted and relatively sharp 1H NMR resonances for paraSHIFT and paraCEST applications.	Hydrogen	95-97	spindlin 1	Homo sapiens	10-14
31458899-1	2018	1H NMR pulsed gradient spin echo attenuation and water density profile analysis by magnetic resonance imaging are both used to determine the mobility of water molecules confined within a porous network of compacted kaolinite clay sample (total porosity of ~50%).	Hydrogen	0-2	spindlin 1	Homo sapiens	23-27
29733595-0	2018	Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase.	Hydrogen	29-37	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	121-160
29760219-1	2018	BACKGROUND: Increased cardiac troponin I or T detected by high-sensitivity assays (hs-cTnI or hs-cTnT) confers an increased risk of adverse prognosis.	Hydrogen	83-85	troponin I3, cardiac type	Homo sapiens	86-90
30426109-2	2018	Glomerulosclerosis could be secondary to tubular injury, but it remains uncertain whether the CLCN5 gene, which encodes an endosomal chloride and/or hydrogen exchanger, plays a role in podocyte biology.	Hydrogen	149-157	chloride voltage-gated channel 5	Homo sapiens	94-99
20140805-7	2010	The structure of AFF1 was elucidated as 3,5,7,3"-tetrahydroxyflavone-3-O-alpha-L-rhamnoside, using a combination of UV, IR, 1D and 2D (COSY) 1H-NMR spectroscopy.	Hydrogen	141-143	AF4/FMR2 family, member 1	Rattus norvegicus	17-21
29625356-2	2018	Even though the "Signal Amplification by Reversible Exchange" (SABRE) approach uses para-enriched hydrogen, p-H2, to repeatedly achieve high polarization levels on target molecules without altering their chemical structure, such studies are often limited to batch experiments in NMR tubes.	Hydrogen	98-106	polyhomeotic homolog 2	Homo sapiens	108-112
20072125-2	2010	Here, using solution NMR, X-ray crystallography, mutagenesis and hydrogen exchange mass spectrometry, we show that GNF-2 binds to the myristate-binding site of Abl, leading to changes in the structural dynamics of the ATP-binding site.	Hydrogen	65-73	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	160-163
19928871-7	2010	The simulations for the denaturation of the polypeptide GB1 in urea solutions showed that the breaking of its native hydrogen bonds follows a step-by-step process and each step is strongly coupled to the formation of water-carbonyl hydrogen bonds, and to a less extent to the urea-carbonyl hydrogen-bond formation.	Hydrogen	232-240	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	56-59
19928871-7	2010	The simulations for the denaturation of the polypeptide GB1 in urea solutions showed that the breaking of its native hydrogen bonds follows a step-by-step process and each step is strongly coupled to the formation of water-carbonyl hydrogen bonds, and to a less extent to the urea-carbonyl hydrogen-bond formation.	Hydrogen	232-240	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	56-59
29733191-3	2018	We have recently applied this technique to condensed matter samples, one of which is solid para-hydrogen ( p-H2).	Hydrogen	91-104	polyhomeotic homolog 2	Homo sapiens	107-111
20356213-3	2010	Here, we demonstrate the spontaneous generation of hydrogen gas from ordinary room-temperature tap water when combined with aluminum-oleic acid core-shell nanoparticles obtained via sonochemistry.	Hydrogen	51-59	nuclear RNA export factor 1	Homo sapiens	95-98
29588365-7	2018	In return, the hydrogen atoms contributed by the side chain of Ser-261 and the main chain of Ser-263 bonded the oxygen atoms of CaV1.2 Asp-181.	Hydrogen	15-23	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	128-134
20839490-7	2010	The relative proportion of KLRG1 + cells among the CD8+ T-cells increased by 40% immediately after exercise, returning to baseline 1h later.	Hydrogen	131-133	killer cell lectin like receptor G1	Homo sapiens	27-32
29743631-2	2018	We theoretically predict the quantum spin Hall effect (QSHE) in the hydrofluorinated bismuth (Bi2HF) nanosheet where the hydrogen (H) and fluorine (F) atoms are functionalized on opposite sides of bismuth (Bi) atomic monolayer.	Hydrogen	121-129	spindlin 1	Homo sapiens	37-41
19843527-4	2009	Comparative analysis of the published CARM1 crystal structures reveals that the hydroxyl group of Ser(217) forms a strong hydrogen bond with the carbonyl oxygen atom of Tyr(154) to lock the cofactor S-adenosylmethionine inside the binding cavity.	Hydrogen	122-130	coactivator associated arginine methyltransferase 1	Homo sapiens	38-43
21580024-3	2009	However, the syn-related proton of the carboxylic acid group forms the common short intra-molecular O-H O(carbox-yl) hydrogen bond.	Hydrogen	117-125	synemin	Homo sapiens	13-16
29620891-4	2018	A CH   G nonbonded attraction between a polar axial substituent (G) and the syn-axial hydrogen(s) in the heterocycle has been demonstrated experimentally.	Hydrogen	86-94	synemin	Homo sapiens	76-79
19874050-5	2009	On the basis of the high-resolution STM images, it was tentatively proposed that three types of chiral supramolecular nanostructures were formed by two-dimensional adsorption-induced chiral p-CPAEt species together with lateral hydrogen-bonding interaction (C-H...N[triple bond]C).	Hydrogen	228-236	sulfotransferase family 1A member 3	Homo sapiens	36-39
29480333-9	2018	Based on simulation results, we demonstrate that wild-SELENOH structure is dynamically stabilized by network of intramolecular hydrogen bonding and internal residue contacts facilitated by Sec residue.	Hydrogen	127-135	selenoprotein H	Homo sapiens	54-61
19770404-6	2009	Furthermore, DOCA/HS-induced renal oxidative stress was significantly attenuated in COMT(-/-) mice.	Hydrogen	18-20	catechol-O-methyltransferase	Mus musculus	84-88
29574323-5	2018	The modeled bi-lobed zCDKL1 shares a high degree of secondary structure topology with human orthologs where ATP prefers to lie in the central cavity of the bi-lobed catalytic domain enclosed by strong hydrogen bonding, electrostatic and hydrophobic contacts.	Hydrogen	201-209	cyclin-dependent kinase-like 1 (CDC2-related kinase)	Danio rerio	21-27
19770404-8	2009	Renal medullary COX-2 expression and urinary prostaglandin E2 excretion were significantly higher in COMT(-/-) than in wild-type mice after DOCA/HS treatment.	Hydrogen	145-147	catechol-O-methyltransferase	Mus musculus	101-105
19543978-5	2009	We include for the first time insight into the active-site geometry and potential hydrogen-bonding interactions along with molecular dynamics simulations describing the opening and closing of the MGL helical-domain lid.	Hydrogen	82-90	monoglyceride lipase	Homo sapiens	196-199
29623332-3	2018	All complexes feature abrupt SCO-behavior with T1/2 between 170 K and 187 K. These materials demonstrate that without stabilizing the effects of incorporated solvents or a hydrogen bond-network, the observed cooperativity during high-spin-low-spin transition is anion independent and originates only from the rigidity and internal strain of the propellane-moiety in the ligand.	Hydrogen	172-180	spindlin 1	Homo sapiens	234-238
19760722-3	2009	Epoxidation with CF(3)CO(3)H was then carried out and was shown to occur with a high level of diastereocontrol: the reagent approaches the diene moiety syn to the amide group, which is likely to be as a consequence of hydrogen bonding between the amide C=O bond and the peracid hydrogen.	Hydrogen	218-226	synemin	Homo sapiens	152-155
19760722-3	2009	Epoxidation with CF(3)CO(3)H was then carried out and was shown to occur with a high level of diastereocontrol: the reagent approaches the diene moiety syn to the amide group, which is likely to be as a consequence of hydrogen bonding between the amide C=O bond and the peracid hydrogen.	Hydrogen	278-286	synemin	Homo sapiens	152-155
19697903-6	2009	The halothane with the highest binding affinity at the interface between the alpha4 and beta2 subunits altered interactions between the protein and nearby lipids by competing for hydrogen bonds.	Hydrogen	179-187	immunoglobulin binding protein 1	Homo sapiens	77-83
28918311-5	2018	LDN-212854 bound to the kinase hinge region as a typical type I ATP-competitive inhibitor with a single hydrogen bond to ALK2 His286.	Hydrogen	104-112	activin A receptor, type 1	Mus musculus	121-125
28918311-6	2018	Specificity arising from the 5-quinoline moiety was associated with a distinct pattern of water-mediated hydrogen bonds involving Lys235 and Glu248 in the inactive conformation favoured by ALK2.	Hydrogen	105-113	activin A receptor, type 1	Mus musculus	189-193
28929458-8	2018	Here we report near complete backbone 15N, 13C and 1H assignments for the BTB-POZ domain of BCL6 to assist in the analysis of binding modes for small molecules.	Hydrogen	51-53	BCL6 transcription repressor	Homo sapiens	92-96
19303701-4	2009	The experimental results showed that PAM/SiO(2) possesses strong adsorption ability for TNT with interaction of three kinds of hydrogen bonds including peculiar NHcdots, three dots, centeredpi hydrogen bond (aromatic hydrogen bond) and CHcdots, three dots, centeredOC pi hydrogen bond.	Hydrogen	127-135	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	37-40
29755306-9	2018	Results: The highest response of the two MOS sensors with 15 nm and 20 nm oxide film thickness in 4% hydrogen concentration was 87.5% and 65.4% respectively.	Hydrogen	101-109	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	41-44
19303701-4	2009	The experimental results showed that PAM/SiO(2) possesses strong adsorption ability for TNT with interaction of three kinds of hydrogen bonds including peculiar NHcdots, three dots, centeredpi hydrogen bond (aromatic hydrogen bond) and CHcdots, three dots, centeredOC pi hydrogen bond.	Hydrogen	193-201	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	37-40
19303701-4	2009	The experimental results showed that PAM/SiO(2) possesses strong adsorption ability for TNT with interaction of three kinds of hydrogen bonds including peculiar NHcdots, three dots, centeredpi hydrogen bond (aromatic hydrogen bond) and CHcdots, three dots, centeredOC pi hydrogen bond.	Hydrogen	193-201	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	37-40
19303701-4	2009	The experimental results showed that PAM/SiO(2) possesses strong adsorption ability for TNT with interaction of three kinds of hydrogen bonds including peculiar NHcdots, three dots, centeredpi hydrogen bond (aromatic hydrogen bond) and CHcdots, three dots, centeredOC pi hydrogen bond.	Hydrogen	193-201	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	37-40
29755306-10	2018	The fast response times for MOS sensors with 15 nm and 20 nm oxide film thickness in 4% hydrogen concentration was 8 s and 21 s, respectively.	Hydrogen	88-96	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	28-31
19591434-6	2009	1D line broadening NMR (1H and 31P) and 2D trNOESY NMR studies indicate that GpIbalpha residues D274-E285 interact extensively with the IIa surface in an extended conformation.	Hydrogen	24-26	glycoprotein Ib platelet subunit alpha	Homo sapiens	77-86
29755306-11	2018	Conclusion: By increasing the hydrogen concentration from 1% to 4%, the response time for MOS sensor (20nm oxide thickness), was decreased from 28s to 21s.	Hydrogen	30-38	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	90-93
19842489-9	2009	Moreover, hydrogen bonds of the type D-H...CL2 within the complexes investigated have been found to be rather strong.	Hydrogen	10-18	endogenous retrovirus group W member 5	Homo sapiens	43-46
30949620-3	2018	Our aim was to investigate the potential clinical applications of MRI spectroscopy (1H-MRS) in a range of suspected SDH-related tumours.	Hydrogen	84-86	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	116-119
19378980-0	2009	The Cl + H2 --&gt; HCl + H reaction induced by IR + UV irradiation of Cl2 in solid para-H2: experiment.	Hydrogen	9-11	endogenous retrovirus group W member 5	Homo sapiens	70-73
19378980-0	2009	The Cl + H2 --&gt; HCl + H reaction induced by IR + UV irradiation of Cl2 in solid para-H2: experiment.	Hydrogen	88-90	endogenous retrovirus group W member 5	Homo sapiens	70-73
19668908-4	2009	Hydrogen breath test was used to evaluate lactulose and bean orocecal transit times.	Hydrogen	0-8	brain expressed associated with NEDD4 1	Homo sapiens	56-60
19503885-0	2009	Photoinduced HS state in the first spin-crossover chain containing a cyanocarbanion as bridging ligand.	Hydrogen	13-15	spindlin 1	Homo sapiens	35-39
19498244-3	2009	Simple hydrogen-bonded chains built from a single N-H...O hydrogen bond are formed in 3-tert-butyl-5-(4-nitrobenzylamino)-1-phenyl-1H-pyrazole, C(20)H(22)N(4)O(2), (VI), while in 3-tert-butyl-5-(3,4,5-trimethoxybenzylamino)-1-phenyl-1H-pyrazole, C(23)H(29)N(3)O(3), (VII), which crystallizes with Z" = 2 in the space group P-1, pairs of molecules are linked into two independent centrosymmetric dimers, one generated by a three-centre N-H...(O)(2) hydrogen bond and the other by a two-centre N-H...O hydrogen bond.	Hydrogen	7-15	crystallin gamma F, pseudogene	Homo sapiens	323-326
19498244-3	2009	Simple hydrogen-bonded chains built from a single N-H...O hydrogen bond are formed in 3-tert-butyl-5-(4-nitrobenzylamino)-1-phenyl-1H-pyrazole, C(20)H(22)N(4)O(2), (VI), while in 3-tert-butyl-5-(3,4,5-trimethoxybenzylamino)-1-phenyl-1H-pyrazole, C(23)H(29)N(3)O(3), (VII), which crystallizes with Z" = 2 in the space group P-1, pairs of molecules are linked into two independent centrosymmetric dimers, one generated by a three-centre N-H...(O)(2) hydrogen bond and the other by a two-centre N-H...O hydrogen bond.	Hydrogen	58-66	crystallin gamma F, pseudogene	Homo sapiens	323-326
19380334-6	2009	Furthermore, the hydrogen bonding networks formed around the active site with INTA and INTB may be the main reason of why the inhibition of PTP1B by the two ligands is so potent and selective.	Hydrogen	17-25	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	140-145
21583288-2	2009	Two ion pairs are hydrogen bonded (2 x O-H O and 2 x N-H O) about a center of inversion, generating an R(4) (4)(14) ring.	Hydrogen	18-26	immunoglobulin kappa variable 1D-39	Homo sapiens	39-50
19408261-3	2009	Formation of hydrogen bonds upon helix folding could contribute significantly to the enhanced enthalpy observed in binding of the linear peptides.The human double minute 2 protein (HDM2) binds a short peptide derived from the N terminus of the tumor-suppressor protein, p53.	Hydrogen	13-21	MDM2 proto-oncogene	Homo sapiens	181-185
19408261-12	2009	In addition, the calculations suggest that at least one stabilizing hydrogen bond is formed, between the Trp indole-NH in both ligands and HDM2.	Hydrogen	68-76	MDM2 proto-oncogene	Homo sapiens	139-143
19408261-13	2009	Other hydrogen-bonding interactions also arise, however, along the alpha-helical backbone of the linear peptide upon binding to HDM2, but are not mimicked in the constrained inhibitor-HDM2 complex.	Hydrogen	6-14	MDM2 proto-oncogene	Homo sapiens	128-132
19408261-14	2009	The formation of these hydrogen bonds upon helix folding could contribute significantly to the enhanced enthalpy observed in binding of the linear peptide to HDM2.	Hydrogen	23-31	MDM2 proto-oncogene	Homo sapiens	158-162
19221175-6	2009	The M22-TSHR complex contains a greater number of hydrogen bonds and salt bridges and fewer hydrophobic interactions than the TSH-TSHR complex, consistent with a higher M22 binding affinity.	Hydrogen	50-58	thyroid stimulating hormone receptor	Homo sapiens	8-12
19239225-11	2009	At pH&lt;4, hydrogen bonding interactions between fully protonated PMAA and PEG led to the formation of another type of micellar aggregates possessing hydrogen-bonded complex cores stabilized by protonated PDEA coronas.	Hydrogen	12-20	phosphodiesterase 6A	Homo sapiens	206-210
19239225-11	2009	At pH&lt;4, hydrogen bonding interactions between fully protonated PMAA and PEG led to the formation of another type of micellar aggregates possessing hydrogen-bonded complex cores stabilized by protonated PDEA coronas.	Hydrogen	151-159	phosphodiesterase 6A	Homo sapiens	206-210
19421516-1	2009	The X-ray single-crystal structure of methyl 2-aminoisobutyrate hydrochloride (Me-AIB), a non-standard amino acid, is reported at 10, 30, 50, 70 and 100 K. Fourier maps indicate the presence of rotational disorder of the hydrogen atoms of the ester methyl group.	Hydrogen	221-229	ANIB1	Homo sapiens	82-85
19368886-7	2009	These different patterns of hydrogen bonds, as well as stacking interactions, may underlie Poliota"s small preference for insertion of dGTP over other nucleotides opposite this common lesion.	Hydrogen	28-36	DNA polymerase mu	Homo sapiens	91-98
19185288-2	2009	NMR studies of several of the intermediates leading to the beta-1,3-glucan show anomalously small coupling constants for some of the C-1 hydrogens.	Hydrogen	137-146	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	59-67
19160436-3	2009	The energy differences were found to be governed by the substituents directly attached to the bipyridine and their ability to form intramolecular hydrogen bonds.Quantum-chemical calculations at the BP86/TZVP level of theory were performed to determine the energy differences between the syn and the anti conformers, as well as the energy barrier for the rotation of the aryl-aryl bond of 2,2"-bipyridine molecules and a number of disubstituted derivatives.	Hydrogen	146-154	synemin	Homo sapiens	287-290
19056727-8	2009	We discuss the possible involvement of Nda2 in cyclic electron flow around PSI, chlororespiration, and hydrogen production.	Hydrogen	103-111	uncharacterized protein	Chlamydomonas reinhardtii	39-43
19164531-4	2009	Hydrogen exchange mass spectrometry (HX MS) was used to compare the conformations of wild-type Abl with a nonmyristoylated form and with 3 clinically relevant imatinib resistance mutants (T315I, Y253H and E255V).	Hydrogen	0-8	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	95-98
19105697-7	2009	Crystallization of OAT2 in the presence of N-alpha-acetyl-L-glutamate led to a structure in which Thr-181 was acetylated; the carbonyl oxygen of the acyl-enzyme complex was located in an oxyanion hole and positioned to hydrogen bond with the backbone amide NH of Gly-112 and the alcohol of Thr-111.	Hydrogen	219-227	solute carrier family 22 member 7	Homo sapiens	19-23
19153467-8	2009	The structures show that the peptides interact with cIAP1 in the same way that they interact with XIAP: both peptides bind in a similar shallow groove in the BIR3 surface, anchored at the N-terminus by a charge-stabilized hydrogen bond.	Hydrogen	222-230	X-linked inhibitor of apoptosis	Homo sapiens	98-102
19378310-2	2009	Selective methylation at less-substituted carbons, relative rates of methylation to hydrogen transfer as a function of chain size, slow skeletal isomerization, and beta-scission cracking of triptyl chains and their precursors are intrinsic properties of carbenium ions and account for the remarkable triptane selectivities within C(7) .	Hydrogen	84-92	complement C7	Homo sapiens	330-334
19053268-6	2008	The PET domain adopts a helical conformation in the presence of 2,2,2-trifluoroethanol (TFE), a solvent known to stabilize hydrogen bonds within the polypeptide backbone, as analyzed by circular dichroism (CD) and NMR spectroscopy.	Hydrogen	123-131	thyroid stimulating hormone receptor	Mus musculus	4-7
29451325-1	2018	A series of purine-based spin labels was prepared for noncovalent spin-labeling of abasic sites of duplex nucleic acids through hydrogen bonding to an orphan base on the opposing strand and pi-stacking interactions with the flanking bases.	Hydrogen	128-136	spindlin 1	Homo sapiens	25-29
18809383-4	2008	The side chain of Lys18 within a Btk-specific insertion in the beta1-beta2 loop is able to form a hydrogen bond with the diacylglycerol moiety of phosphatidylinositol.	Hydrogen	98-106	Bruton tyrosine kinase	Homo sapiens	33-36
29451325-1	2018	A series of purine-based spin labels was prepared for noncovalent spin-labeling of abasic sites of duplex nucleic acids through hydrogen bonding to an orphan base on the opposing strand and pi-stacking interactions with the flanking bases.	Hydrogen	128-136	spindlin 1	Homo sapiens	66-70
29505238-0	2018	Tunable Pt-MoS x Hybrid Catalysts for Hydrogen Evolution.	Hydrogen	38-46	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	11-14
18998682-4	2008	Experimental tests showed that hydrogen abstraction proceeds at reasonable rates for substrates having BDE(CH) values less than 82 kcal/mol.	Hydrogen	31-39	homeobox D13	Homo sapiens	103-106
29780493-3	2018	A tapelike hydrogen-bonded supramolecular array of barbiturated oligo(butylthiophene) molecules was directly visualized by STM at a liquid-solid interface.	Hydrogen	11-19	sulfotransferase family 1A member 3	Homo sapiens	123-126
18855413-0	2008	Hydrogen sensor based on Au and YSZ/HgO/Hg electrode for in situ measurement of dissolved H2 in high-temperature and -pressure fluids.	Hydrogen	0-8	homogentisate 1,2-dioxygenase	Homo sapiens	36-39
29531348-5	2018	Small-angle X-ray scattering (SAXS) complemented with hydrogen-deuterium exchange mass spectrometry (HDX-MS) data allowed us to obtain 3D structural models comprising a trimeric dUTPase complexed with separate Stl monomers.	Hydrogen	54-62	Deoxyuridine triphosphatase	Drosophila melanogaster	178-185
18855413-0	2008	Hydrogen sensor based on Au and YSZ/HgO/Hg electrode for in situ measurement of dissolved H2 in high-temperature and -pressure fluids.	Hydrogen	90-92	homogentisate 1,2-dioxygenase	Homo sapiens	36-39
18855413-2	2008	The dissolved H2 sensor, constructed with a Au-based sensing element and coupled with a YSZ/HgO/Hg electrode, is well suited for determining dissolved H2 concentrations of aqueous fluids at elevated temperatures and pressures.	Hydrogen	14-16	homogentisate 1,2-dioxygenase	Homo sapiens	92-95
18855413-2	2008	The dissolved H2 sensor, constructed with a Au-based sensing element and coupled with a YSZ/HgO/Hg electrode, is well suited for determining dissolved H2 concentrations of aqueous fluids at elevated temperatures and pressures.	Hydrogen	151-153	homogentisate 1,2-dioxygenase	Homo sapiens	92-95
18855413-7	2008	0603 log m H2 The experimental results indicate that the Au-YSZ/HgO/Hg cell can be used to measure the solubility of H2 in aqueous fluid at temperatures and pressures near to the critical state of water.	Hydrogen	11-13	homogentisate 1,2-dioxygenase	Homo sapiens	64-67
18855413-7	2008	0603 log m H2 The experimental results indicate that the Au-YSZ/HgO/Hg cell can be used to measure the solubility of H2 in aqueous fluid at temperatures and pressures near to the critical state of water.	Hydrogen	117-119	homogentisate 1,2-dioxygenase	Homo sapiens	64-67
32254424-3	2018	Here, we introduce a method to form a tetrazine group in situ by catalytic oxidation of the dihydrogen tetrazine using horse radish peroxidase (HRP).	Hydrogen	92-102	peroxidase E5-like	Raphanus sativus	132-142
18773908-4	2008	Unlike conventional tetraloop-receptor interactions, which are stabilized by extensive hydrogen-bonding interactions, the GANC-receptor interaction is limited to a single base stack between the conserved adenosine of the tetraloop and a single purine of the receptor, which consists of a one- to three-nucleotide bulge and does not contain an A-platform.	Hydrogen	87-95	glucosidase alpha, neutral C	Homo sapiens	122-126
29217181-3	2018	Thermodynamic analysis of the binding process suggested that hydrogen bonding and van der Waals interactions are the major forces in the interaction of TPM with hCA II.	Hydrogen	61-69	carbonic anhydrase 2	Homo sapiens	161-167
19012568-5	2008	By [15N-1H] HSQC NMR studies we revealed that c-VIAF binds to the RING domain of XIAP and characterized the important residues involved in the binding.	Hydrogen	8-10	X-linked inhibitor of apoptosis	Homo sapiens	81-85
18663492-5	2008	Implementing classical quantitative structure-activity relationship (QSAR) studies, substitution by an electron-donating group at the C17 position and the presence of a hydrogen bond acceptor at C11, along with the orientation and conformational rigidity of the molecule, were found to be critically important features for estrogenic potency, including anti-fertility activity.	Hydrogen	169-177	aldo-keto reductase family 1 member C4	Homo sapiens	195-198
29281767-3	2018	Here, we report niobium pentoxide/carbon/niobium carbide (MXene) hybrid materials (Nb2 O5 /C/Nb2 C) as photocatalysts for hydrogen evolution from water splitting.	Hydrogen	122-130	contactin 5	Homo sapiens	83-86
29281767-3	2018	Here, we report niobium pentoxide/carbon/niobium carbide (MXene) hybrid materials (Nb2 O5 /C/Nb2 C) as photocatalysts for hydrogen evolution from water splitting.	Hydrogen	122-130	contactin 5	Homo sapiens	93-96
29281767-6	2018	With an optimized oxidation time of 1.0 h, Nb2 O5 /C/Nb2 C showed the highest hydrogen generation rate (7.81 mumol h-1  gcat-1 ), a value that was four times higher than that of pure Nb2 O5 .	Hydrogen	78-86	contactin 5	Homo sapiens	43-46
29281767-6	2018	With an optimized oxidation time of 1.0 h, Nb2 O5 /C/Nb2 C showed the highest hydrogen generation rate (7.81 mumol h-1  gcat-1 ), a value that was four times higher than that of pure Nb2 O5 .	Hydrogen	78-86	contactin 5	Homo sapiens	53-56
18687687-8	2008	Molecular docking studies, supported by site-directed mutagenesis experiments, showed that EGCG could form a series of intermolecular hydrogen bonds and hydrophobic interactions within the ATP binding domain, which may contribute to the stability of the ZAP-70-EGCG complex.	Hydrogen	134-142	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	254-260
29281767-6	2018	With an optimized oxidation time of 1.0 h, Nb2 O5 /C/Nb2 C showed the highest hydrogen generation rate (7.81 mumol h-1  gcat-1 ), a value that was four times higher than that of pure Nb2 O5 .	Hydrogen	78-86	contactin 5	Homo sapiens	53-56
29281767-7	2018	The enhanced performance of Nb2 O5 /C/Nb2 C was attributed to intimate contact between Nb2 O5 and conductive Nb2 C and the separation of photogenerated charge carriers at the Nb2 O5 /Nb2 C interface; the results presented herein show that transition-metal carbide are promising co-catalysts for photocatalytic hydrogen production.	Hydrogen	310-318	contactin 5	Homo sapiens	28-31
29281767-7	2018	The enhanced performance of Nb2 O5 /C/Nb2 C was attributed to intimate contact between Nb2 O5 and conductive Nb2 C and the separation of photogenerated charge carriers at the Nb2 O5 /Nb2 C interface; the results presented herein show that transition-metal carbide are promising co-catalysts for photocatalytic hydrogen production.	Hydrogen	310-318	contactin 5	Homo sapiens	38-41
29281767-7	2018	The enhanced performance of Nb2 O5 /C/Nb2 C was attributed to intimate contact between Nb2 O5 and conductive Nb2 C and the separation of photogenerated charge carriers at the Nb2 O5 /Nb2 C interface; the results presented herein show that transition-metal carbide are promising co-catalysts for photocatalytic hydrogen production.	Hydrogen	310-318	contactin 5	Homo sapiens	38-41
18766096-16	2008	An inverse relationship was found between hydrogen ion concentration and concentrations of tumor necrosis factor-alpha and interleukin-10.	Hydrogen	42-50	interleukin 10	Homo sapiens	123-137
29281767-7	2018	The enhanced performance of Nb2 O5 /C/Nb2 C was attributed to intimate contact between Nb2 O5 and conductive Nb2 C and the separation of photogenerated charge carriers at the Nb2 O5 /Nb2 C interface; the results presented herein show that transition-metal carbide are promising co-catalysts for photocatalytic hydrogen production.	Hydrogen	310-318	contactin 5	Homo sapiens	38-41
29281767-7	2018	The enhanced performance of Nb2 O5 /C/Nb2 C was attributed to intimate contact between Nb2 O5 and conductive Nb2 C and the separation of photogenerated charge carriers at the Nb2 O5 /Nb2 C interface; the results presented herein show that transition-metal carbide are promising co-catalysts for photocatalytic hydrogen production.	Hydrogen	310-318	contactin 5	Homo sapiens	38-41
29281767-7	2018	The enhanced performance of Nb2 O5 /C/Nb2 C was attributed to intimate contact between Nb2 O5 and conductive Nb2 C and the separation of photogenerated charge carriers at the Nb2 O5 /Nb2 C interface; the results presented herein show that transition-metal carbide are promising co-catalysts for photocatalytic hydrogen production.	Hydrogen	310-318	contactin 5	Homo sapiens	38-41
18808674-0	2008	Homonuclear 1H NMR and circular dichroism study of the HIV-1 Tat Eli variant.	Hydrogen	12-14	Tat	Human immunodeficiency virus 1	61-64
29328535-0	2018	An Exceptionally Close, Non-Bonded Hydrogen-Hydrogen Contact with Strong Through-Space Spin-Spin Coupling.	Hydrogen	35-43	spindlin 1	Homo sapiens	87-91
29328535-0	2018	An Exceptionally Close, Non-Bonded Hydrogen-Hydrogen Contact with Strong Through-Space Spin-Spin Coupling.	Hydrogen	35-43	spindlin 1	Homo sapiens	92-96
29328535-0	2018	An Exceptionally Close, Non-Bonded Hydrogen-Hydrogen Contact with Strong Through-Space Spin-Spin Coupling.	Hydrogen	44-52	spindlin 1	Homo sapiens	87-91
18590744-4	2008	Molecular dynamics simulations for unbound CCR5 showed hydrogen bond interactions among transmembrane residues Y108, E283, and Y251, which were crucial for HIV-1-gp120/sCD4 complex binding and HIV-1 fusion.	Hydrogen	55-63	C-C motif chemokine receptor 5	Homo sapiens	43-47
29328535-0	2018	An Exceptionally Close, Non-Bonded Hydrogen-Hydrogen Contact with Strong Through-Space Spin-Spin Coupling.	Hydrogen	44-52	spindlin 1	Homo sapiens	92-96
18590744-5	2008	Indeed, AK530 and AK317, when bound to CCR5, disrupted these interhelix hydrogen bond interactions, a salient molecular mechanism enabling allosteric inhibition.	Hydrogen	72-80	C-C motif chemokine receptor 5	Homo sapiens	39-43
29328535-3	2018	Furthermore, the two in-hydrogen atoms show obvious spin-spin coupling with J=2.0 Hz.	Hydrogen	24-32	spindlin 1	Homo sapiens	52-56
29328535-3	2018	Furthermore, the two in-hydrogen atoms show obvious spin-spin coupling with J=2.0 Hz.	Hydrogen	24-32	spindlin 1	Homo sapiens	57-61
29352967-8	2018	This occurs by abstraction of the proR and proS hydrogens at C-11 and C-8, respectively, in agreement with different "head to tail" orientation in the active site.	Hydrogen	48-57	RNA polymerase III subunit K	Homo sapiens	61-65
18683931-1	2008	Combining information from time-resolved X-ray and neutron scattering with theoretical calculations has revealed the elegant mechanism whereby hydrogen crystalline silicotitanate (H-CST; H2Ti2SiO7 x 1.5 H2O) achieves its remarkable ion-exchange selectivity for cesium.	Hydrogen	143-151	cystatin 12, pseudogene	Homo sapiens	182-185
29365270-3	2018	We present results of a scanning tunneling microscopy/scanning tunneling spectroscopy (STM/STS) study of individual intragap states observed on the surfaces of hydrogen-passivated SiNCs deposited on the Au(111) surface.	Hydrogen	160-168	sulfotransferase family 1A member 3	Homo sapiens	87-90
18651140-4	2008	Hya was found to be required for hydrogen-dependent reduction of azo compound by resting cell suspensions and to be essential for growth with hydrogen as electron donor and azo compound as electron acceptor.	Hydrogen	33-41	lysine demethylase 5D	Homo sapiens	0-3
29303596-11	2018	The complexes and other previously reported compounds were employed as photosensitizers (PS) in preliminary studies on the production of H2 from water using [Co(bpy)3]Cl2 (bpy = 2,2"-bipyridine) as catalyst and triethanolamine (TEOA) as the sacrificial reductant.	Hydrogen	137-139	endogenous retrovirus group W member 5	Homo sapiens	167-170
18651140-4	2008	Hya was found to be required for hydrogen-dependent reduction of azo compound by resting cell suspensions and to be essential for growth with hydrogen as electron donor and azo compound as electron acceptor.	Hydrogen	142-150	lysine demethylase 5D	Homo sapiens	0-3
18666767-5	2008	Spectral changes were observed for the PK1 after doping, which supported the ionic, hydrogen, and halogen bond formation between the PK1 and protonation agents (dopants).	Hydrogen	84-92	prokineticin 1	Homo sapiens	39-42
18666767-5	2008	Spectral changes were observed for the PK1 after doping, which supported the ionic, hydrogen, and halogen bond formation between the PK1 and protonation agents (dopants).	Hydrogen	84-92	prokineticin 1	Homo sapiens	133-136
29175029-2	2018	Here, we measured changes in Pde4b and Atf3 in the cAMP signaling pathway of dopaminergic system components, including the nucleus accumbens (NAc), caudate putamen (CPu) and hippocampus (Hip), in D3R knockout mice(D3R-/-) 1h and 24h after METH-induced behavioral sensitization.	Hydrogen	222-224	phosphodiesterase 4B, cAMP specific	Mus musculus	29-34
29217257-2	2018	Ten min, 1h and 3h after the combined chemical and thermal stimulation an up to 2-fold increase in BDNF and Il-1ss protein expression was observed in the lumbar dorsal spinal cord.	Hydrogen	9-11	brain-derived neurotrophic factor	Rattus norvegicus	99-103
28707052-2	2018	The gained results are observed not only the unbinding mechanism of IRK-PTP1B complexes came from pulling force profile, number of hydrogen bonds, and interaction energy between IRK and PTP1Bs but also described PTP1B"s point mutations could variably change its binding affinity towards IRK.	Hydrogen	131-139	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	72-77
18698916-5	2008	From the present experimental results on calorimetric, structural, and dynamic properties, it has been concluded that supercooled D(2)O confined in MCM-41 C10 experiences a transition from high-density to low-density hydrogen-bonded structure at around 229 K.	Hydrogen	217-225	chromosome 12 open reading frame 57	Homo sapiens	155-158
18474681-3	2008	We have purified the N3- and N1-glucuronides of dexmedetomidine, termed DG1 and DG2, respectively, according to their elution order in liquid chromatography and determined their structure by 1H nuclear magnetic resonance (NMR).	Hydrogen	191-193	desmoglein 1	Homo sapiens	72-75
28707052-2	2018	The gained results are observed not only the unbinding mechanism of IRK-PTP1B complexes came from pulling force profile, number of hydrogen bonds, and interaction energy between IRK and PTP1Bs but also described PTP1B"s point mutations could variably change its binding affinity towards IRK.	Hydrogen	131-139	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	186-191
29382835-2	2018	Here, using the Na+ de-intercalation/intercalation of a Na0.44MnO2 electrode as a redox mediator, we decouple the chlor-alkali process into two independent steps: a H2 production step with the NaOH formation in the electrolyte and a Cl2 production step.	Hydrogen	165-167	endogenous retrovirus group W member 5	Homo sapiens	233-236
18573304-5	2008	In addition, pretreatment of PC12 cells with 10 microg/ml curcumin for 1h significantly reversed the effect of Abeta, by decreasing the oxidative stress, and DNA damage induced by Abeta, as well as attenuating the elevation of intracellular calcium levels and tau hyperphosphorylation induced by Abeta.	Hydrogen	71-73	amyloid beta precursor protein	Rattus norvegicus	111-116
18573304-5	2008	In addition, pretreatment of PC12 cells with 10 microg/ml curcumin for 1h significantly reversed the effect of Abeta, by decreasing the oxidative stress, and DNA damage induced by Abeta, as well as attenuating the elevation of intracellular calcium levels and tau hyperphosphorylation induced by Abeta.	Hydrogen	71-73	amyloid beta precursor protein	Rattus norvegicus	180-185
18573304-5	2008	In addition, pretreatment of PC12 cells with 10 microg/ml curcumin for 1h significantly reversed the effect of Abeta, by decreasing the oxidative stress, and DNA damage induced by Abeta, as well as attenuating the elevation of intracellular calcium levels and tau hyperphosphorylation induced by Abeta.	Hydrogen	71-73	amyloid beta precursor protein	Rattus norvegicus	180-185
29105162-7	2018	The reaction of [(PNN)Fe(CO)2 ] with HBpin (4,4,5,5-tetramethyl-1,3,2-dioxaborolane) resulted in the reduction of the metal center (by release of H2 ) and borylation of the pyrazole beta-nitrogen atom.	Hydrogen	146-148	pinin, desmosome associated protein	Homo sapiens	18-21
18597482-4	2008	However, in the complex of the Asp90 --&gt; Asn mutant dUTPase with the true substrate dUTP.Mg, the serine beta-OH points in the opposite direction and may form a hydrogen bond to Asn84 at the bottom of the pyrimidine pocket.	Hydrogen	163-171	Deoxyuridine triphosphatase	Drosophila melanogaster	55-62
18597482-9	2008	We find that the E. coli dUTPase does not catalyze the hydrolysis of the alpha,beta-imido-dUTP.Mg, suggesting that the analogue provides the hydrogen in the bond to the serine beta-OH.	Hydrogen	141-149	Deoxyuridine triphosphatase	Drosophila melanogaster	25-32
29371621-6	2018	Most importantly, based on the simulation observation that resveratrol has a high probability of forming hydrogen bonds with sn-1 and sn-2 ester groups, we discovered a new mechanism using experimental approach, in which resveratrol protects both sn-1 and sn-2 ester bonds of DPPC and distearoyl phosphatidylcholine (DSPC) from phospholipase A1 (PLA1) and phospholipase A2 (PLA2) cleavage.	Hydrogen	105-113	phospholipase A2 group IIA	Homo sapiens	374-378
29139184-4	2018	The X-ray single-crystal structure revealed that the strong positive cooperativity likely originates from eight C-H   O hydrogen bonds between the two head-to-head-arranged syn tube molecules.	Hydrogen	120-128	synemin	Homo sapiens	173-176
18586490-3	2008	Utilizing a benzimidazole carboxamide scaffold in which the amide forms a key intramolecular hydrogen bond for optimal interaction with the enzyme, we have identified a novel series of PARP inhibitors containing a quaternary methylene-amino substituent at the C-2 position of the benzimidazole.	Hydrogen	93-101	poly (ADP-ribose) polymerase family, member 1	Mus musculus	185-189
29225126-4	2018	Dynamic simulations found a hydrogen bond between Y573 and D496 and also a significant conformational change in the helical form of the LPP intermediate.	Hydrogen	28-36	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	136-139
18822479-0	2008	[Spa and resort treatment of patients with ischemic heart disease including magnetopeloido therapy and sulfurated hydrogen baths].	Hydrogen	114-122	surfactant protein A2	Homo sapiens	1-4
29059712-11	2018	HPN directly interacted with PTP1B by binding to the catalytic domain through hydrogen bonds in a competitive mode.	Hydrogen	78-86	hepsin	Mus musculus	0-3
18406084-5	2008	Probably, linalool and cineole interfered with hydrogen bonding between GP1 molecules while limonene could have initiated a phase separation-mediated gelation, changing the gel morphology.	Hydrogen	47-55	GTP binding protein 1	Homo sapiens	72-75
18452303-2	2008	The identity and purity of both macrocycles MC1 and MC2 were verified by 1H and 13C NMR, elemental analysis, as well as MALDI-TOF MS.	Hydrogen	73-75	melanocortin 5 receptor	Homo sapiens	52-55
19636913-0	2008	1H, 15N, 13C resonance assignment of folded and 8 M urea-denatured state of SUMO from Drosophila melanogaster.	Hydrogen	0-2	smt3	Drosophila melanogaster	76-80
19636923-0	2008	1H, 15N, and 13C NMR chemical shift assignments for the Ig3 domain of palladin.	Hydrogen	0-2	palladin, cytoskeletal associated protein	Homo sapiens	70-78
18238849-2	2008	Serine-glucocorticoid kinase-1 (SGK-1) increases sodium-hydrogen exchanger-3 (NHE3) expression and is known to be upregulated in in vitro and in vivo models of diabetic nephropathy.	Hydrogen	56-64	serum/glucocorticoid regulated kinase 1	Homo sapiens	0-30
18238849-2	2008	Serine-glucocorticoid kinase-1 (SGK-1) increases sodium-hydrogen exchanger-3 (NHE3) expression and is known to be upregulated in in vitro and in vivo models of diabetic nephropathy.	Hydrogen	56-64	serum/glucocorticoid regulated kinase 1	Homo sapiens	32-37
18238849-2	2008	Serine-glucocorticoid kinase-1 (SGK-1) increases sodium-hydrogen exchanger-3 (NHE3) expression and is known to be upregulated in in vitro and in vivo models of diabetic nephropathy.	Hydrogen	56-64	solute carrier family 9 member A3	Homo sapiens	78-82
18443424-5	2008	Based on structural and biochemical information about RANKL and the OPG peptides, we suggest that complex formation between the peptide and RANKL is mediated by both hydrophobic and hydrogen bonding interactions.	Hydrogen	182-190	TNF superfamily member 11	Homo sapiens	54-59
18443424-5	2008	Based on structural and biochemical information about RANKL and the OPG peptides, we suggest that complex formation between the peptide and RANKL is mediated by both hydrophobic and hydrogen bonding interactions.	Hydrogen	182-190	TNF superfamily member 11	Homo sapiens	140-145
17924423-1	2008	Absolute configurations of a number of cis-dihydrodiols (cis-1,2-dihydroxy-3,5-cyclohexadienes), synthetically useful products of TDO-catalyzed dihydroxylations of 1,2- and 1,3-disubstituted benzene derivatives, have been determined by a comparison of calculated and experimental CD spectra and optical rotations and by methods involving X-ray crystallography, 1H NMR spectra of diastereoisomeric derivatives, and by stereochemical correlations.	Hydrogen	361-363	tryptophan 2,3-dioxygenase	Homo sapiens	130-133
18041758-5	2008	Glucosyltriazolylacetamide is accommodated in the catalytic site of the enzyme and the glucopyranose interacts in a manner similar to that observed in the GPb-alpha-D-glucose complex, while the substituent group in the beta-position of the C1 atom makes additional hydrogen bonding and van der Waals interactions to the protein.	Hydrogen	265-273	glycogen phosphorylase B	Homo sapiens	155-158
18359116-5	2008	Similarly, the half-life of a pathogenic PINK1 mutant (L347P) that did not interact with Hsp90 or Cdc37/p50 was only 30min, whereas that of wild-type PINK1 was 1h.	Hydrogen	160-162	PTEN induced kinase 1	Homo sapiens	41-46
18376879-2	2008	The global minima of both the deoxyadenosine (dA) and deoxyguanosine (dG) adducts adopted a syn conformation about the glycosidic bond due to the presence of an O5"-H...N3 hydrogen bond, where the anti minima are 20-30 kJ mol-1 higher in energy.	Hydrogen	172-180	synemin	Homo sapiens	92-95
18230622-7	2008	Its inhibitory action was dependent on the association of TRPC4alpha with actin cytoskeleton as it was prevented by cytochalasin D treatment or by the deletion of the C-terminal PDZ-binding motif (Thr-Thr-Arg-Leu) that links TRPC4 to F-actin through the sodium-hydrogen exchanger regulatory factor and ezrin.	Hydrogen	261-269	transient receptor potential cation channel subfamily C member 4	Homo sapiens	58-63
18343900-3	2008	From a derived significant correlation equation for inhibition of VEGFR-2, it was concluded that a less hydrophobic molecule with ortho-substituent(s), exerting less steric hindrance and para-substituent devoid of hydrogen-bond acceptor property augment the inhibition action.	Hydrogen	214-222	kinase insert domain receptor	Homo sapiens	66-73
18078997-7	2008	Although this particular structural feature could be due to crystallization artifacts or intrinsic variability, we propose that molecular mechanisms at the basis of the enhanced interaction between Fc/3M and CD16 could include enhanced Fc openness as well as the introduction of additional hydrophobic contacts, hydrogen bonds and/or electrostatic interactions at the corresponding interface.	Hydrogen	312-320	Fc gamma receptor IIIa	Homo sapiens	208-212
18260615-3	2008	Investigation of the SAR reveals that a sterically unhindered hydrogen bond acceptor attached to C-17 is most likely key to the enhanced activity.	Hydrogen	62-70	sarcosine dehydrogenase	Homo sapiens	21-24
17936691-6	2008	The three-dimensional prediction by SWISS-PROT mouse and fly delta-ALA-D revealed differences in the number of hydrogen bonds and turns for the 2 enzymes.	Hydrogen	111-119	Porphobilinogen synthase	Drosophila melanogaster	61-72
17851586-7	2008	As reported previously, the homologous residue D295 of HAUSP/USP-7 forms a hydrogen bond with the C-terminal end of ubiquitin and is important for the enzymatic activity.	Hydrogen	75-83	ubiquitin specific peptidase 7	Homo sapiens	55-60
17851586-7	2008	As reported previously, the homologous residue D295 of HAUSP/USP-7 forms a hydrogen bond with the C-terminal end of ubiquitin and is important for the enzymatic activity.	Hydrogen	75-83	ubiquitin specific peptidase 7	Homo sapiens	61-66
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Hydrogen	197-205	spleen trypsin inhibitor I	Bos taurus	38-42
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Hydrogen	197-205	spleen trypsin inhibitor I	Bos taurus	157-161
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Hydrogen	197-205	spleen trypsin inhibitor I	Bos taurus	157-161
18155726-6	2008	The structure reveals that the D-alanyl moiety of the covalent intermediate (N-benzoyl-d-alanine) is stabilized in the cleft by a network of hydrogen bonds that place the carbonyl group in close proximity to the oxyanion hole, thus mimicking the spatial arrangement of beta-lactam antibiotics within the PBP active site.	Hydrogen	141-149	phosphatidylethanolamine binding protein 1	Homo sapiens	304-307
18159923-3	2008	The structure of a factor Xa cocrystal containing 7-fluoroindazole 51a showed the 7-fluoro atom hydrogen-bonding with the N-H of Gly216 (2.9 A) in the peptide backbone.	Hydrogen	96-104	coagulation factor X	Homo sapiens	19-28
18159923-4	2008	Thus, the 7-fluoroindazolyl moiety not only occupied the same space as the carbonyl group of an amide found in prior factor Xa inhibitors but also maintained a hydrogen bond interaction with the protein"s beta-sheet domain.	Hydrogen	160-168	coagulation factor X	Homo sapiens	117-126
18078705-11	2008	Treatment with APAP for 1h caused a significant increase in the levels of haem oxygenase-1 (HO-1; 2.85-fold) and glutamate cysteine ligase (GCLC; 1.62-fold) mRNA.	Hydrogen	24-26	glutamate-cysteine ligase, catalytic subunit	Mus musculus	140-144
29059712-11	2018	HPN directly interacted with PTP1B by binding to the catalytic domain through hydrogen bonds in a competitive mode.	Hydrogen	78-86	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	29-34
18453743-6	2008	We engineered a cobalt coordination site and reduction/oxidation sensitivity in Kir2.3 by introduction of a cysteine into the putatively hydrogen bonding residue (Kir2.3(H117C)) confirming that this residue is in proximity to Kir2.3(C141).	Hydrogen	137-145	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	80-86
29210386-4	2017	The dissociative chemisorption of H2 and O2 on the Pt surface through a Langmuir-Hinshelwood mechanism leads to the formation of chemisorbed hydrogen and hydroxyl groups.	Hydrogen	141-149	relaxin 2	Homo sapiens	34-43
18453743-6	2008	We engineered a cobalt coordination site and reduction/oxidation sensitivity in Kir2.3 by introduction of a cysteine into the putatively hydrogen bonding residue (Kir2.3(H117C)) confirming that this residue is in proximity to Kir2.3(C141).	Hydrogen	137-145	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	163-169
18453743-6	2008	We engineered a cobalt coordination site and reduction/oxidation sensitivity in Kir2.3 by introduction of a cysteine into the putatively hydrogen bonding residue (Kir2.3(H117C)) confirming that this residue is in proximity to Kir2.3(C141).	Hydrogen	137-145	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	163-169
18063384-4	2008	Both reactions were theoretically demonstrated by density functional theory calculations [B3LYP/6-311++G(d,p)+ZPE] to involve hydrogen-bridged radical cations as key intermediates.	Hydrogen	126-134	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	92-95
18052134-4	2007	The calculated results suggest a proton-transferred hydrogen bond between HO2 and H2O in H3O3+ wherein a proton is partially transferred to H2O producing the O2...H3O+ structure.	Hydrogen	52-60	H3 clustered histone 15	Homo sapiens	89-92
17958401-4	2007	The highly ionic rhombic (KH)2 molecule is formed by dimerization and trapped in solid hydrogen.	Hydrogen	87-95	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	11-30
18167444-4	2007	The squalene synthase inhibitor was identified as chlorogenic acid with a molecular mass of 354 Da and a molecular formula of C16H18O9 based on UV spectrophotometry, 1H and 13C NMRs, and mass spectrometry.	Hydrogen	166-168	farnesyl-diphosphate farnesyltransferase 1	Sus scrofa	4-21
17785454-0	2007	Conformational analysis of Epac activation using amide hydrogen/deuterium exchange mass spectrometry.	Hydrogen	55-63	Rap guanine nucleotide exchange factor 3	Homo sapiens	27-31
17785454-2	2007	To delineate the mechanism of Epac activation, we probed the conformation and structural dynamics of Epac using amide hydrogen/deuterium exchange and structural modeling.	Hydrogen	118-126	Rap guanine nucleotide exchange factor 3	Homo sapiens	101-105
17980039-9	2007	CONCLUSION: These investigations identify different roles that hydrogen bond donors and acceptors on bases in both cognate and non-cognate RNA play in the specific recognition of RNA by the U1A protein.	Hydrogen	63-71	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	190-193
17336137-1	2007	The structural and vibrational features of the hydrogen bonded complexes of 1,5,7-triazabicyclo [4.4.0] dec-5-ene (TBD) with one and two 4-CNPhOH molecules have been studied extensively by ab initio SCF/6-31G(d,p) and BLYP calculations with various basis sets: 6-31G(d,p), 6-31+G(d,p) and 6-31++G(d,p).	Hydrogen	47-55	KIT ligand	Homo sapiens	199-202
17251160-5	2007	The beta-turn, a ubiquitous structural feature formed by two residue (alphaalpha) segments in proteins and peptides, is stabilized by a 10-atom (C10) intramolecular 4--&gt;1 hydrogen bond.	Hydrogen	174-182	chromosome 12 open reading frame 57	Homo sapiens	145-148
17616181-6	2007	Coupling of the ortho phenyl protons to the spin 1/2 isotopes of Sn and of Pb was a characteristic feature of the 1H NMR spectrum.	Hydrogen	114-116	spindlin 1	Homo sapiens	44-52
17917856-1	2007	Extensive hydrogen bonding of dyes to connective tissue fibers is made possible by the high content of the amino acids proline and glycine in elastin and collagens.	Hydrogen	10-18	elastin	Homo sapiens	142-149
17567734-4	2007	The drastic effect of mutations of Glu227, Arg247, Asp252, and Glu281 on GlcAT-I activity indicated a key role for the hydrogen bond network formed by these four conserved residues in dictating Gal2 binding.	Hydrogen	119-127	galectin 2	Homo sapiens	194-198
17609564-2	2007	The observed syn conformation is controlled by both intramolecular N-H...O hydrogen bonds and intermolecular C-H...pi interactions.	Hydrogen	75-83	synemin	Homo sapiens	13-16
17452315-5	2007	Mutation of residues in the JAM-A dimer interface that participate in salt-bridge or hydrogen-bond interactions with apposing JAM-A monomers abolishes the capacity of JAM-A to form dimers.	Hydrogen	85-93	F11 receptor	Homo sapiens	28-33
17356751-1	2007	Hydrides of period 2 and 3 elements are promising candidates for hydrogen storage, but typically have heats of reaction that are too high to be of use for fuel cell vehicles.	Hydrogen	65-73	period circadian regulator 2	Homo sapiens	12-26
17182181-3	2007	Basal forebrain TrkA levels increased after injection of NGF in the hippocampus within 1h in young rats, but this response was diminished in aged animals as determined by Western blot analysis.	Hydrogen	87-89	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	16-20
17188241-5	2007	The modeled structures of hGS show that the central portions of the G- and A-loop have a double role in the reactant complex conformation: they bind the substrates and simultaneously interact with each other through an extensive network of hydrogen bonds.	Hydrogen	240-248	hepatocyte growth factor-regulated tyrosine kinase substrate	Homo sapiens	26-29
17268463-0	2007	The signature of hot hydrogen in the atmosphere of the extrasolar planet HD 209458b.	Hydrogen	21-29	alcohol dehydrogenase iron containing 1	Homo sapiens	17-20
17268463-6	2007	Here we report the detection of absorption by hot hydrogen in the atmosphere of HD 209458b.	Hydrogen	50-58	alcohol dehydrogenase iron containing 1	Homo sapiens	46-49
17243818-2	2007	Here, we provide a quantitative assessment of the relative strengths of hydrogen bonds involving phosphorylated amino acid side chains (pSer, pAsp) with several common donors (Arg, Lys, and backbone amide groups).	Hydrogen	72-80	carboxypeptidase B1	Homo sapiens	142-146
17243818-7	2007	A pSer hydrogen-bond acceptor tends to form more stable interactions than a pAsp acceptor.	Hydrogen	7-15	carboxypeptidase B1	Homo sapiens	76-80
17243818-8	2007	The effect of phosphate protonation state on the strengths of the hydrogen bonds is remarkably subtle, with a more pronounced effect on pAsp than on pSer.	Hydrogen	66-74	carboxypeptidase B1	Homo sapiens	136-140
17696185-2	2007	It has been found that Boc-Ala-Gly(=S)-Ala-Aib-OMe in acetonitrile, as well as its oxopeptide analogue, can adopt a hydrogen-bonded loop conformation in coexistence with less restricted structures.	Hydrogen	116-124	ANIB1	Homo sapiens	43-46
17696185-4	2007	The hydrogen bond between the Boc terminal group and the amide proton of Aib can be broken by photoisomerisation of the thioamide bond.	Hydrogen	4-12	ANIB1	Homo sapiens	73-76
17568121-6	2007	The gene investigated in these examples was SNAT3, which is responsible for the cotransport of sodium predominantly with glutamine in exchange for hydrogen ions.	Hydrogen	147-155	solute carrier family 38, member 3	Rattus norvegicus	44-49
17365795-6	2007	Finally, we investigated the [15N4]-PR-ADA 1:1 complex by 2D-(1H-15N) NMR.	Hydrogen	62-64	adenosine deaminase	Homo sapiens	39-42
29210387-3	2017	The results show that H3O+ accumulates at the membrane surface where it displaces water and forms strong and long-lived hydrogen bonds with the phosphate and carbonyl oxygens in phospholipids.	Hydrogen	120-128	H3 clustered histone 15	Homo sapiens	22-25
29148771-6	2017	Notably, we predict that AAG excises Hx in a concerted mechanism that is facilitated through correct alignment of the (E125) general base due to hydrogen bonding with a neighboring aromatic amino acid (Y127).	Hydrogen	145-153	N-methylpurine DNA glycosylase	Homo sapiens	25-28
29086476-3	2017	All results are consistent with the initial formation of [(n PDI2 )Co2 (mu-N)(PMe3 )2 ]3+ , followed by 1) PMe3 attack on the nitride, 2) net hydrogen-atom transfer to form N-H bonds, or 3) C-H amination of the alkyl linker of the n PDI2 ligand.	Hydrogen	142-150	peptidyl arginine deiminase 2	Homo sapiens	61-65
29030428-6	2017	Functional studies of site-directed mutants revealed that loss of latch interactions or the entire lid enhanced activity against soluble ester substrates, and hydrogen-deuterium exchange (HDX) mass spectrometry revealed that the LCAT lid is extremely dynamic in solution.	Hydrogen	159-167	lecithin-cholesterol acyltransferase	Homo sapiens	229-233
29148785-2	2017	Specifically, using protein GB1 K28C-EDTA-Cu2+ mutant as a model, we show the determination of backbone amide 15N longitudinal and 1H transverse PREs within a few hours of experiment time based on proton-detected 2D or 3D correlation spectra recorded with magic-angle spinning frequencies &gt;= ~ 60 kHz for samples containing ~10-50 nanomoles of 2H,13C,15N-labeled protein back-exchanged in H2O.	Hydrogen	131-133	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	28-31
28892705-1	2017	In this study, the effect of reduced hydrogen partial pressure (PH2) on the generation of carboxylic acids from acidogenic fermentation of glucose was investigated.	Hydrogen	37-45	polyhomeotic homolog 2	Homo sapiens	64-67
29107423-5	2017	Moreover, molecular modeling evaluation of these BACE1 inhibitors demonstrates the vital role of the amine and amide linkers through hydrogen bond interactions with key amino acids in the BACE1 active site.	Hydrogen	133-141	beta-secretase 1	Rattus norvegicus	49-54
29107423-5	2017	Moreover, molecular modeling evaluation of these BACE1 inhibitors demonstrates the vital role of the amine and amide linkers through hydrogen bond interactions with key amino acids in the BACE1 active site.	Hydrogen	133-141	beta-secretase 1	Rattus norvegicus	188-193
27940340-8	2017	Furthermore, four important hydrogen bonds were found to be involved with the docking of FA on tyrosinase.	Hydrogen	28-36	tyrosinase	Homo sapiens	95-105
29226743-2	2017	In the crystal structure of the tetrameric fumarase, it was found that some of the active site residues S145, T147, N188 G364 and H235 had water-mediated hydrogen bonding interactions with pyromellitic acid and citrate which help to the protonation state for the conversion of fumarate to malate.	Hydrogen	154-162	fumarate hydratase	Homo sapiens	43-51
29144141-3	2017	A nonclassical hydrogen bond between the axial CN group and the syn-axial hydrogens is a major contributor to the axial stability of the group.	Hydrogen	15-23	synemin	Homo sapiens	64-67
29144141-3	2017	A nonclassical hydrogen bond between the axial CN group and the syn-axial hydrogens is a major contributor to the axial stability of the group.	Hydrogen	74-83	synemin	Homo sapiens	64-67
17223530-0	2007	Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters.	Hydrogen	68-76	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	Homo sapiens	32-58
28993160-10	2017	The treatment with BAM8-22 for 1h inhibited chronic morphine-induced increase of MMP-9 and IL-1beta mRNA in DRG but these effects were abolished by MrgC receptor antibody.	Hydrogen	31-33	matrix metallopeptidase 9	Rattus norvegicus	81-86
16439082-10	2006	Based on this re-evaluation an accuracy of death time estimation has been recommended (95% limits of confidence of +/-1h in the early PMI and +/-10h, 110h postmortem) which has surpassed even optimistic results of earlier investigations.	Hydrogen	118-120	transmembrane protein 11	Homo sapiens	134-137
28890349-9	2017	Moreover, we showed that H2 simultaneously induced the H3K27 demethylase, Jmjd3, and mitochondrial unfolded protein response (mtUPR)-related genes.	Hydrogen	25-27	lysine demethylase 6B	Rattus norvegicus	74-79
27678281-3	2017	The four point LBPM; ADPR.14 suggested the presence of one hydrogen bond acceptor, one hydrogen bond donor, one positive ionizable, and one ring aromatic feature for Syk inhibitory activity and AADH.54 proposed the necessity of two hydrogen bond acceptor, one hydrogen bond donor, and one hydrophobic feature for JAK3 inhibitory activity.	Hydrogen	59-67	spleen associated tyrosine kinase	Homo sapiens	166-169
17203116-8	2006	A reduction in water consumption and an increase in urine output as well as urinary hydrogen ion were noted in SCaR compared with SR. Calcium alone (CaR) did not have any effect on MAP (88.01 +/- 1.3 mmHg) and HR (413 +/- 7.98 beats/min).	Hydrogen	84-92	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	112-115
27678281-3	2017	The four point LBPM; ADPR.14 suggested the presence of one hydrogen bond acceptor, one hydrogen bond donor, one positive ionizable, and one ring aromatic feature for Syk inhibitory activity and AADH.54 proposed the necessity of two hydrogen bond acceptor, one hydrogen bond donor, and one hydrophobic feature for JAK3 inhibitory activity.	Hydrogen	87-95	spleen associated tyrosine kinase	Homo sapiens	166-169
27678281-3	2017	The four point LBPM; ADPR.14 suggested the presence of one hydrogen bond acceptor, one hydrogen bond donor, one positive ionizable, and one ring aromatic feature for Syk inhibitory activity and AADH.54 proposed the necessity of two hydrogen bond acceptor, one hydrogen bond donor, and one hydrophobic feature for JAK3 inhibitory activity.	Hydrogen	87-95	spleen associated tyrosine kinase	Homo sapiens	166-169
27678281-3	2017	The four point LBPM; ADPR.14 suggested the presence of one hydrogen bond acceptor, one hydrogen bond donor, one positive ionizable, and one ring aromatic feature for Syk inhibitory activity and AADH.54 proposed the necessity of two hydrogen bond acceptor, one hydrogen bond donor, and one hydrophobic feature for JAK3 inhibitory activity.	Hydrogen	87-95	spleen associated tyrosine kinase	Homo sapiens	166-169
17155753-3	2006	By desorbing this hydrogen atom with the STM tip, the interaction of the molecule with the surface is modified such that it becomes transformed into a multistable device with four stable states having switching yields increased by almost 2 orders of magnitude.	Hydrogen	18-26	sulfotransferase family 1A member 3	Homo sapiens	41-44
27678281-5	2017	For Syk inhibitory activity, the hydrogen bond acceptor feature indicated by LBPM was devoid of forming hydrogen bonding interaction with the hinge region amino acid residue (Ala451).	Hydrogen	33-41	spleen associated tyrosine kinase	Homo sapiens	4-7
29045385-10	2017	GNE-6640 and GNE-6776 interact with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain, suggesting that USP7 preferentially interacts with and cleaves ubiquitin moieties that have free Lys48 side chains.	Hydrogen	65-73	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
17098192-3	2006	Using molecular simulations of monomeric and aggregated states, we demonstrate that elastin-like and amyloid-like peptides are separable on the basis of backbone hydration and peptide-peptide hydrogen bonding.	Hydrogen	192-200	elastin	Homo sapiens	84-91
29045385-10	2017	GNE-6640 and GNE-6776 interact with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain, suggesting that USP7 preferentially interacts with and cleaves ubiquitin moieties that have free Lys48 side chains.	Hydrogen	65-73	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	13-16
29045385-10	2017	GNE-6640 and GNE-6776 interact with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain, suggesting that USP7 preferentially interacts with and cleaves ubiquitin moieties that have free Lys48 side chains.	Hydrogen	65-73	ubiquitin specific peptidase 7	Homo sapiens	145-149
28990631-2	2017	The metal ion sensing ability of PTB-1 was explored by various experimental (naked-eye, UV-Vis, fluorescence, mass spectrometry and 1H NMR spectroscopy) and theoretical (B3LYP/6-31G**/LANL2DZ) methods.	Hydrogen	132-134	polypyrimidine tract binding protein 1	Homo sapiens	33-38
17002377-2	2006	We have identified the most reactive oxygenated species and presented new insights into the hydrogen abstraction (H-abstraction) mechanism operative in PHM.	Hydrogen	92-100	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	152-155
29055316-11	2017	CHD2O reacts with H2 with a rate coefficient (6.0 +- 1.4) x 10-3 s-1; CD2OH was produced as a major product because the barrier for the formation of CHDOH from H + CHD2OH is greater by ~400 cm-1.	Hydrogen	18-20	chromodomain helicase DNA binding protein 2	Homo sapiens	0-4
16913910-2	2006	Using quantitative reverse transcriptase polymerase chain reaction, we found that genes encoding a periplasmic Hup hydrogenase and the Fdh were the most highly expressed in batch-grown pure cultures, in which the H2 partial pressure was &gt;0.1 atm, and in butyrate/tetrachloroethene-mixed cultures, in which H2 partial pressures were 10(-4)-10(-5) atm.	Hydrogen	213-215	polysulfide reductase NrfD	Dehalococcoides mccartyi 195	135-138
29055316-11	2017	CHD2O reacts with H2 with a rate coefficient (6.0 +- 1.4) x 10-3 s-1; CD2OH was produced as a major product because the barrier for the formation of CHDOH from H + CHD2OH is greater by ~400 cm-1.	Hydrogen	18-20	chromodomain helicase DNA binding protein 2	Homo sapiens	164-168
16913910-2	2006	Using quantitative reverse transcriptase polymerase chain reaction, we found that genes encoding a periplasmic Hup hydrogenase and the Fdh were the most highly expressed in batch-grown pure cultures, in which the H2 partial pressure was &gt;0.1 atm, and in butyrate/tetrachloroethene-mixed cultures, in which H2 partial pressures were 10(-4)-10(-5) atm.	Hydrogen	309-311	polysulfide reductase NrfD	Dehalococcoides mccartyi 195	135-138
28960976-0	2017	Stereochemical Characterization of Polyketide Stereotriads Synthesized via Hydrogen-Mediated Asymmetric syn-Crotylation.	Hydrogen	75-83	synemin	Homo sapiens	104-107
16913714-7	2006	A protein-ligand X-ray crystal structure of inhibitor 3-bound HIV-1 protease (1.35 A resolution) revealed extensive interactions in the HIV protease active site including strong hydrogen bonding interactions with the backbone.	Hydrogen	178-186	protein phosphatase 1 regulatory inhibitor subunit 11	Homo sapiens	44-55
28960976-1	2017	The stereoselective access to stereotriads as important polyketide building blocks is reported on the basis of the Krische-type hydrogen-mediated syn-crotylation.	Hydrogen	128-136	synemin	Homo sapiens	146-149
28960976-4	2017	This extension of the burgeoning transfer hydrogen methodology gives divergent asymmetric access to anti,syn and syn,syn polyketide stereotriads from the same alpha-chiral starting material and avoids potentially epimerizable aldehyde intermediates.	Hydrogen	42-50	synemin	Homo sapiens	105-108
28960976-4	2017	This extension of the burgeoning transfer hydrogen methodology gives divergent asymmetric access to anti,syn and syn,syn polyketide stereotriads from the same alpha-chiral starting material and avoids potentially epimerizable aldehyde intermediates.	Hydrogen	42-50	synemin	Homo sapiens	113-116
28960976-4	2017	This extension of the burgeoning transfer hydrogen methodology gives divergent asymmetric access to anti,syn and syn,syn polyketide stereotriads from the same alpha-chiral starting material and avoids potentially epimerizable aldehyde intermediates.	Hydrogen	42-50	synemin	Homo sapiens	113-116
29163819-8	2017	Moreover, the expression of procaspase-3 and caspase-12 were extremely enhanced after OGD, especially 1h after OGR.	Hydrogen	102-104	caspase 12	Rattus norvegicus	45-55
28981004-3	2017	It was found that a dimeric cation [Acc5(Z)...Acc5(C)]+ bonded by an O-H...O hydrogen bond exists due to a charge transfer between acid and carboxylate groups.	Hydrogen	77-85	cathepsin H	Homo sapiens	36-40
28981004-3	2017	It was found that a dimeric cation [Acc5(Z)...Acc5(C)]+ bonded by an O-H...O hydrogen bond exists due to a charge transfer between acid and carboxylate groups.	Hydrogen	77-85	cathepsin H	Homo sapiens	46-50
28338290-6	2017	Further, the conformational transition, hydrogen bond interactions, and the binding energies were investigated during 10-ns molecular dynamics simulation of the Abl-hit complex.	Hydrogen	40-48	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	161-164
28695374-4	2017	1H NMR spectroscopy studies performed on complexes 1 and 2 demonstrated that after the hydrolysis of the Cl ligand, they are capable to interact with guanine derivatives (i.e., 9-methylguanine (9MeG) and 5"-GMP) through the N7, forming monofunctional adduct.	Hydrogen	0-2	5'-nucleotidase, cytosolic II	Homo sapiens	207-210
28455789-10	2017	Both agonists induced similar chemical shift changes in the 13C-1H-heteronuclear single quantum correlation (HSQC) spectrum of CXCR4 in membranes, whereas CXCL11 did not significantly alter the 13C-1H-HSQC spectrum of CXCR4.	Hydrogen	64-66	C-X-C motif chemokine receptor 4	Homo sapiens	127-132
28686430-2	2017	Herein we present a combined theoretical and experimental study that leads to the identification of alpha-phase molybdenum diboride (alpha-MoB2) comprising borophene subunits as a noble metal-free, superefficient electrocatalyst for the hydrogen evolution reaction (HER).	Hydrogen	237-245	MOB kinase activator 2	Homo sapiens	139-143
28686430-3	2017	Our theoretical finding indicates, unlike the surfaces of Pt- and MoS2-based catalysts, those of alpha-MoB2 can maintain high catalytic activity for HER even at very high hydrogen coverage and attain a high density of efficient catalytic active sites.	Hydrogen	171-179	MOB kinase activator 2	Homo sapiens	103-107
28912833-3	2017	RESULTS: Herein, we report a promiscuous activity of tyrosinase which is closely associated with delignification requiring high redox potentials (&gt;1.4 V vs. normal hydrogen electrode [NHE]).	Hydrogen	167-175	tyrosinase	Homo sapiens	53-63
28339149-1	2017	Tenapanor (RDX5791/AZD1722) is a minimally systemic small-molecule inhibitor of the sodium/hydrogen exchanger NHE3.	Hydrogen	91-99	solute carrier family 9 member A3	Homo sapiens	110-114
28795606-8	2017	The protein expressions of mucin MUC5C and aquaporin 5 involved in mucus hypersecretion were analyzed by Western blot and ELISA and the data revealed that hydrogen-rich saline down-regulated MUC5AC level in bronchoalveolar lavage fluid and lung tissue and up-regulated aquaporin 5 level in lung tissue of chronic obstructive pulmonary disease rats.	Hydrogen	155-163	mucin 5AC, oligomeric mucus/gel-forming	Rattus norvegicus	191-197
28792591-4	2017	In this study, we show that L31 in helix 2 (H2) is critical for stabilization of the helix bundle fold in the CARD domain.	Hydrogen	44-46	ribosomal protein L31	Homo sapiens	28-31
28802213-3	2017	We investigated hydrogen adsorption onto twenty six nitrogen disubstituted isomers of sumanene (C19N2H12) by MP2/6-311++G(d,p)//B3LYP/6-31+G(d) and M06-2X/6-31+G(d) levels of theory.	Hydrogen	16-24	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	130-133
28786673-2	2017	While the accepted mechanism of Schreiner"s catalyst features a double hydrogen bond to the substrate that only forms with the anti-anti conformation of its central thiourea group, our electronic-structure theory study reveals that binding of the model substrate methyl vinyl ketone prefers syn-anti conformations.	Hydrogen	71-79	synemin	Homo sapiens	291-294
28720507-8	2017	In contrast, a transient 1h pre-treatment of O6GB before HN2 exposure would cause a high MGMT and mDPC level.	Hydrogen	25-27	O-6-methylguanine-DNA methyltransferase	Homo sapiens	89-93
28848432-0	2017	Hydrogen-Rich Saline Alleviates Kidney Fibrosis Following AKI and Retains Klotho Expression.	Hydrogen	0-8	klotho	Mus musculus	74-80
28585418-1	2017	The ability to catalyze the oxidation of both H2 and CO in one reaction pot would be a major boon to hydrogen technology since CO is a consistent contaminant of H2 supplies.	Hydrogen	101-109	relaxin 2	Homo sapiens	46-55
28614179-8	2017	Furthermore, H2 treatment significantly ameliorated the increase in serum and hippocampal proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and high-mobility group protein 1 in surgery-challenged animals.	Hydrogen	13-15	high mobility group box 1	Rattus norvegicus	183-212
28477975-5	2017	Analysis of individual mutations suggested specific hydrogen bonding and other molecular interactions involved in AQP4-IgG binding to AQP4.	Hydrogen	52-60	aquaporin 4	Homo sapiens	114-118
16581150-4	2006	In the presence of Ca(2+), the alpha-amylase had residual activity of more than 92% after 1h of incubation at 70 degrees Celsius.	Hydrogen	90-92	alpha-amylase	Solanum tuberosum	31-44
28477975-5	2017	Analysis of individual mutations suggested specific hydrogen bonding and other molecular interactions involved in AQP4-IgG binding to AQP4.	Hydrogen	52-60	aquaporin 4	Homo sapiens	134-138
16581150-5	2006	The alpha-amylase did not lose any activity in the presence of phytate (a selective alpha-amylase inhibitor) at concentrations as high as 10mM, rather it retained 90% maximal activity after 1h of incubation at 70 degrees Celsius.	Hydrogen	190-192	alpha-amylase	Solanum tuberosum	4-17
28646302-9	2017	Interleukin (IL)-1beta, IL-6, IL-8 and IL-10 levels in the serum all increased POST-1h (P &gt; 0.05) but returned to pre-exercise levels POST-1d.	Hydrogen	84-86	interleukin 10	Homo sapiens	39-44
16894158-3	2006	ColE9 folds into a distorted hairpin within a canyon of the six-bladed beta-propeller of TolB, using two tryptophans to bolt the toxin to the canyon floor and numerous intramolecular hydrogen bonds to stabilize the bound conformation.	Hydrogen	183-191	colicin E9	Escherichia coli	0-5
27453381-5	2017	Concurrently, thermodynamic parameters indicate that the binding process was spontaneous, and the complexes were stabilized mostly by hydrophobic interactions, except for NF2 has one hydrogen bond stabilizes it along with hydrophobic interactions.	Hydrogen	183-191	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	171-174
16884501-7	2006	We discuss the possibility of using heterologous expression of NDH-2 enzymes to improve nonphotochemical reduction of plastoquinones and H2 production in C. reinhardtii.	Hydrogen	137-139	NADH-ubiquinone reductase (H(+)-translocating) NDE2	Saccharomyces cerevisiae S288C	63-68
28549582-6	2017	cR8 forms extensive hydrogen bonding with SPSB2 residues, but loss of an intramolecular hydrogen bond that is present in SPSB2-bound iNOS peptide may destabilize the bound conformation of cR8 and lead to a gentle reduction in SPSB2 binding affinity.	Hydrogen	88-96	splA/ryanodine receptor domain and SOCS box containing 2	Homo sapiens	121-126
16859295-4	2006	SLICK accounts for van der Waals interactions, solvation effects, electrostatics, hydrogen bonds, and CH...pi interactions, the latter being a particular feature of most protein-carbohydrate interactions.	Hydrogen	82-90	potassium sodium-activated channel subfamily T member 2	Homo sapiens	0-5
28549582-6	2017	cR8 forms extensive hydrogen bonding with SPSB2 residues, but loss of an intramolecular hydrogen bond that is present in SPSB2-bound iNOS peptide may destabilize the bound conformation of cR8 and lead to a gentle reduction in SPSB2 binding affinity.	Hydrogen	88-96	splA/ryanodine receptor domain and SOCS box containing 2	Homo sapiens	121-126
28602073-2	2017	The system produces hydrogen at a turnover of about 240 mumol of H2 (mumol protein)-1 h-1 and 17.74 mmol of H2 (mumol protein)-1 h-1 under monochromatic green and white light, respectively, at ambient conditions, in water at neutral pH and room temperature, with methanol as a sacrificial electron donor.	Hydrogen	20-28	relaxin 2	Homo sapiens	65-89
28602073-2	2017	The system produces hydrogen at a turnover of about 240 mumol of H2 (mumol protein)-1 h-1 and 17.74 mmol of H2 (mumol protein)-1 h-1 under monochromatic green and white light, respectively, at ambient conditions, in water at neutral pH and room temperature, with methanol as a sacrificial electron donor.	Hydrogen	20-28	relaxin 2	Homo sapiens	65-85
28594639-2	2017	We focus on the (1e,1h) charge configuration with a single excess electron of the conduction band confined in the n-type dot and a single missing electron in the valence band state of the p-type dot for which lifting of the Pauli blockade of the current was observed in the electric-dipole spin resonance (Laird et al 2013 Nat.	Hydrogen	20-22	spindlin 1	Homo sapiens	290-294
28761933-4	2017	The butyrogenic reactor was operated at 37 C and pH 5.5 with a hydraulic retention time of 31 h and a low hydrogen partial pressure (PH2).	Hydrogen	106-114	polyhomeotic homolog 2	Homo sapiens	133-136
28616991-1	2017	Despite the fact that the para-hydrogen molecule (p-H2) and its isotopomers (o-D2 and p-T2) are commonly modeled as spherical objects due to the large separation between rotational states, there may be situations (e.g. adsorption in pores and on surfaces) in which such an approximation neglects important degrees of freedom (i.e. the rotational ones) and introduces uncontrolled biases in the predicted properties.	Hydrogen	31-39	polyhomeotic homolog 2	Homo sapiens	50-54
28315058-3	2017	H2 production in R25 was also favored at a HRT of 4 h, with maximum yield and HPR values of 0.64 +- 0.023 mmol H2 g COD-1 and 0.31 +- 0.032 l H2 h-1 l-1, respectively.	Hydrogen	0-2	retinitis pigmentosa GTPase regulator	Homo sapiens	116-121
27957768-1	2017	Here, we studied the influence of the methoxyl groups attached at C-7 and C-2" of natural and synthetic 1-arylindanes on the chemical shift of the signal of bibenzylic hydrogen and carbon atoms and J1,2 coupling constants.	Hydrogen	168-176	complement C7	Homo sapiens	66-69
28691068-0	2017	Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling.	Hydrogen	0-8	linoleate 9S-lipoxygenase-4	Glycine max	31-43
28604870-2	2017	We present the results of the reaction H + HONO in solid para-hydrogen (p-H2) at 3.3 K investigated with infrared spectra.	Hydrogen	57-70	polyhomeotic homolog 2	Homo sapiens	72-76
28604870-3	2017	Two methods that produced hydrogen atoms were the irradiation of HONO molecules in p-H2 at 365 nm to produce OH radicals that reacted readily with nearby H2 to produce mobile H atoms, and irradiation of Cl2 molecules (co-deposited with HONO) in p-H2 at 405 nm to produce Cl atoms that reacted, upon IR irradiation of the p-H2 matrix, readily with nearby H2 to produce mobile H atoms.	Hydrogen	26-34	polyhomeotic homolog 2	Homo sapiens	83-87
28604870-3	2017	Two methods that produced hydrogen atoms were the irradiation of HONO molecules in p-H2 at 365 nm to produce OH radicals that reacted readily with nearby H2 to produce mobile H atoms, and irradiation of Cl2 molecules (co-deposited with HONO) in p-H2 at 405 nm to produce Cl atoms that reacted, upon IR irradiation of the p-H2 matrix, readily with nearby H2 to produce mobile H atoms.	Hydrogen	26-34	polyhomeotic homolog 2	Homo sapiens	245-249
28604870-3	2017	Two methods that produced hydrogen atoms were the irradiation of HONO molecules in p-H2 at 365 nm to produce OH radicals that reacted readily with nearby H2 to produce mobile H atoms, and irradiation of Cl2 molecules (co-deposited with HONO) in p-H2 at 405 nm to produce Cl atoms that reacted, upon IR irradiation of the p-H2 matrix, readily with nearby H2 to produce mobile H atoms.	Hydrogen	26-34	polyhomeotic homolog 2	Homo sapiens	245-249
28636951-3	2017	Several structural features appeared to contribute to the anti-HIV potency of [5P7]CCL5, including the distinct chemokine orientation relative to the receptor, the near-complete occupancy of the receptor binding pocket, the dense network of intermolecular hydrogen bonds, and the similarity of binding determinants with the FDA-approved HIV inhibitor Maraviroc.	Hydrogen	256-264	C-C motif chemokine ligand 5	Homo sapiens	83-87
27987191-3	2017	The optimal conditions for hydrogen production were the HRT of 4 h and temperature of 65  C in AFBR-CW, observing maximum hydrogen yield (HY) of 5.51 +- 0.37 mmol H2 g COD-1.	Hydrogen	27-35	retinitis pigmentosa GTPase regulator	Homo sapiens	168-173
27987191-3	2017	The optimal conditions for hydrogen production were the HRT of 4 h and temperature of 65  C in AFBR-CW, observing maximum hydrogen yield (HY) of 5.51 +- 0.37 mmol H2 g COD-1.	Hydrogen	122-130	retinitis pigmentosa GTPase regulator	Homo sapiens	168-173
28481111-0	2017	Conformational Changes in Active and Inactive States of Human PP2Calpha Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.	Hydrogen	89-97	protein phosphatase, Mg2+/Mn2+ dependent 1A	Homo sapiens	62-71
28481111-4	2017	Here, we report the use of hydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha between the active and inactive states.	Hydrogen	27-35	protein phosphatase, Mg2+/Mn2+ dependent 1A	Homo sapiens	138-147
28402665-9	2017	Simulations also predict that about 52% of the total flux of decomposition of HN-3 leads to the formation of N,N-diethenyl-2-chloroethylamine (P29), which acts as a chain branching agent because its unimolecular decomposition is preponderant and produces one chlorine and one hydrogen atoms.	Hydrogen	276-284	MT-RNR2 like 3 (pseudogene)	Homo sapiens	78-82
28405648-1	2017	Transition metal dichalcogenides, MX2 (M = Fe, Co, Ni, X = S, Se, Te), have been proven to be promising substitutes for noble metals in hydrogen evolution reactions (HERs).	Hydrogen	136-144	MX dynamin like GTPase 2	Homo sapiens	34-37
28496315-9	2017	RESULTS: The results showed that hydrogen inhalation significantly reduced the number of inflammatory cells in the bronchoalveolar lavage fluid, and the mRNA and protein expression levels of tumor necrosis factor alpha, IL-6, IL-17, IL-23, matrix metalloproteinase-12, caspase-3, and caspase-8, but increased the tissue inhibitor of metalloproteinase-1 expression.	Hydrogen	33-41	caspase 8	Rattus norvegicus	284-293
28496315-9	2017	RESULTS: The results showed that hydrogen inhalation significantly reduced the number of inflammatory cells in the bronchoalveolar lavage fluid, and the mRNA and protein expression levels of tumor necrosis factor alpha, IL-6, IL-17, IL-23, matrix metalloproteinase-12, caspase-3, and caspase-8, but increased the tissue inhibitor of metalloproteinase-1 expression.	Hydrogen	33-41	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	313-352
28289995-5	2017	In addition, from the UV-vis titration, fluorescence titration,Job"s plot and 1H NMR spectra analysis, we could primarily confirm that three important coordinative sites of P-1 for Al3+ were from imine nitrogen and tertiary amine nitrogen and formed a 1:1 complex.	Hydrogen	78-80	crystallin gamma F, pseudogene	Homo sapiens	173-176
16261298-4	2006	The planar B7H 2- (C2v, 1A1) isomer 4, originated from the addition of two hydrogen atoms to the doubly antiaromatic B7- isomer 3, becomes the global minimum structure.	Hydrogen	75-83	inducible T cell costimulator ligand	Homo sapiens	11-16
27979268-3	2017	The Cu-NGr composite was prepared by one pot synthesis from a mixture of graphene oxide, copper nitrate and uric acid, followed by thermal annealing at 900 C for 1h.	Hydrogen	162-164	reticulon 4 receptor	Homo sapiens	7-10
16644251-1	2006	A theoretical model for 1H-1H dipolar nuclear spin relaxation for a bi-spaced periodic one-dimensional array of spin 1/2 nuclei has been developed.	Hydrogen	24-26	spindlin 1	Homo sapiens	46-50
16644251-1	2006	A theoretical model for 1H-1H dipolar nuclear spin relaxation for a bi-spaced periodic one-dimensional array of spin 1/2 nuclei has been developed.	Hydrogen	24-26	spindlin 1	Homo sapiens	112-120
16644251-1	2006	A theoretical model for 1H-1H dipolar nuclear spin relaxation for a bi-spaced periodic one-dimensional array of spin 1/2 nuclei has been developed.	Hydrogen	27-29	spindlin 1	Homo sapiens	46-50
16644251-1	2006	A theoretical model for 1H-1H dipolar nuclear spin relaxation for a bi-spaced periodic one-dimensional array of spin 1/2 nuclei has been developed.	Hydrogen	27-29	spindlin 1	Homo sapiens	112-120
28258193-3	2017	Here, we employed hydrogen-deuterium exchange mass spectrometry to describe the structure and dynamics of iC3b at a peptide resolution level in direct comparison with its parent protein C3b.	Hydrogen	18-26	complement C3	Homo sapiens	107-110
16738410-2	2006	U1A binds to U1hpII via direct interactions with a 7-nucleotide (nt) consensus binding sequence at the 5" end of a 10-nt loop, and via hydrogen bonds with the closing C-G base pair at the top of the RNA stem.	Hydrogen	135-143	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	0-3
28439541-0	2017	Potential energy-driven spin manipulation via a controllable hydrogen ligand.	Hydrogen	61-69	spindlin 1	Homo sapiens	24-28
16776516-2	2006	On addition of the competitive guest, the supramolecular structure formed by a mixture of the alpha-CD-beta-CD hetero-dimer and G-t-Boc was found to be different from that of a mixture of the alpha-CD-beta-CD hetero-dimer and G-NH2 by the 1H NMR spectroscopy, the ROESY NMR spectroscopy, and the circular dichroism spectroscopy.	Hydrogen	239-241	BOC cell adhesion associated, oncogene regulated	Homo sapiens	132-135
28439541-5	2017	We show that the total spin changes when the system is transferred onto a new potential energy surface that is defined by the position of the hydrogen in the junction.	Hydrogen	142-150	spindlin 1	Homo sapiens	23-27
16704279-5	2006	The hydrogen bond parameters: r(O(epoxy)...H), angle(ring-O(epoxy)...H), and angle(O(epoxy)...H-O) are 1.908 A, 112 degrees, and 177 degrees for syn-PO-H(2)O, and 1.885 A, 104.3 degrees, and 161.7 degrees for anti-PO-H(2)O, respectively.	Hydrogen	4-12	synemin	Homo sapiens	145-148
28339201-5	2017	As the 1D 1H and 13C NMR data are ubiquitous and most routinely used in solution structure elucidation, this fast and efficient two-criterion method (nuclear spin-spin coupling and 13C chemical shifts) which we term DU8+ is recommended as the first essential step in structure assignment and validation.	Hydrogen	10-12	spindlin 1	Homo sapiens	158-162
16704279-6	2006	The experimental results suggest that the hydrogen bond in syn-PO-H(2)O is stronger and the monomer subunits are more rigidly locked in their positions than in the ethylene oxide-water adduct.	Hydrogen	42-50	synemin	Homo sapiens	59-62
16706533-3	2006	Heating atropisomeric diacid 1 with various hydrogen-bonding guests leads to a shift in the syn/anti ratio that could be easily monitored as it is stable at room temperature even in the absence of the guest molecules.	Hydrogen	44-52	synemin	Homo sapiens	92-95
28339201-5	2017	As the 1D 1H and 13C NMR data are ubiquitous and most routinely used in solution structure elucidation, this fast and efficient two-criterion method (nuclear spin-spin coupling and 13C chemical shifts) which we term DU8+ is recommended as the first essential step in structure assignment and validation.	Hydrogen	10-12	spindlin 1	Homo sapiens	163-167
19127729-6	2006	Y290F and Y367F MTSases had large changes in delta(deltaG), suggesting that there are hydrogen bonds between the substrate and residues Y290 and Y367 of wild-type MTSase.	Hydrogen	86-94	IS110 family transposase	Saccharolobus solfataricus	16-22
28346551-1	2017	We report infrared (IR) spectra of HSCS+, c-HSCS, HCS2-, and other species produced on electron bombardment of a mixture of CS2 and para-hydrogen (p-H2) during deposition at 3.2 K. After maintenance of the deposited matrix in darkness for 12 h, the intensities of the absorption lines of HSCS+ at 2477.2 (nu1), 1525.6 (nu2), and 919.6 cm-1 (nu3) decreased through neutralization of HSCS+ with trapped electrons.	Hydrogen	137-145	polyhomeotic homolog 2	Homo sapiens	147-151
16640434-1	2006	Hydrides of period 2 and 3 elements are promising candidates for hydrogen storage but typically have heats of reaction that are too high to be of use for fuel cell vehicles.	Hydrogen	65-73	period circadian regulator 2	Homo sapiens	12-26
16609772-16	2006	Alternatively, 1*(+) undergoes a reductive elimination of H2 from the AsH2 group via a remarkably stable complex of the phenylarsandiyl radical cation, [C6H5As]*+ and an H2 molecule.	Hydrogen	58-60	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	70-74
28246117-8	2017	Transport by CLC-ec1 is reduced when [Cl-] is symmetrically increased on both sides of the membrane and mutations that disrupt the hydrogen bonds stabilizing Gluex in Scen destabilize this trapped state.	Hydrogen	131-139	Charcot-Leyden crystal galectin	Homo sapiens	13-16
28246117-10	2017	Collectively, our results suggest that, during the CLC transport cycle, Gluex can occupy Scen as well as the Sext position in which it has been captured crystallographically and that hydrogen bonds with the side chains of residues that coordinate ion binding to Scen play a role in determining the equilibrium between these two conformations.	Hydrogen	183-191	Charcot-Leyden crystal galectin	Homo sapiens	51-54
28251489-8	2017	Molecular docking simulation predicted that eckol and dieckol exhibit higher binding affinity towards hMAO-A and hMAO-B through hydrogen bonding and hydrophobic interactions.	Hydrogen	128-136	monoamine oxidase B	Homo sapiens	113-119
16415170-0	2006	H2 complex controls CD4/CD8 ratio, recurrent responsiveness to repeated stimulations, and resistance to activation-induced apoptosis during T cell response to mycobacterial antigens.	Hydrogen	0-2	CD4 antigen	Mus musculus	20-23
28091961-0	2017	1H, 13C and 15N backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2.	Hydrogen	0-2	ubiquitin specific peptidase 20	Homo sapiens	87-92
28091961-0	2017	1H, 13C and 15N backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2.	Hydrogen	0-2	ubiquitin specific peptidase 20	Homo sapiens	93-97
28247282-0	2017	Backbone 1H, 13C, and 15N NMR resonance assignments of the Kruppel-like factor 4 activation domain.	Hydrogen	9-11	Kruppel like factor 4	Homo sapiens	59-80
16548516-7	2006	A titratable perturbation is observed at the 1H resonance of the 8-CH3 group of CYP101-bound camphor upon addition of cytochrome b5, a phenomenon also associated with the formation of the CYP101 x Pdx complex, albeit with larger perturbations [Wei, J. Y., et al.	Hydrogen	45-47	cytochrome b5 type A	Rattus norvegicus	118-131
16551744-4	2006	The predicted structures for apo-beta2AR and butoxamine-beta2AR are stable in MD, but in epinephrine-beta2AR, extracellular water trickles into the binding pocket to mediate hydrogen bonding between the catechol of epinephrine and Ser-204 on helix 5.	Hydrogen	174-182	adrenoceptor beta 2	Homo sapiens	56-63
16551744-4	2006	The predicted structures for apo-beta2AR and butoxamine-beta2AR are stable in MD, but in epinephrine-beta2AR, extracellular water trickles into the binding pocket to mediate hydrogen bonding between the catechol of epinephrine and Ser-204 on helix 5.	Hydrogen	174-182	adrenoceptor beta 2	Homo sapiens	56-63
16551744-5	2006	The epinephrine-beta2AR structure shows dynamic flexibility with small, piston-like movements of helices 3 and 6 and transient interhelical hydrogen bonding between Ser-165 on transmembrane 4 and Ser-207 on transmembrane 5.	Hydrogen	140-148	adrenoceptor beta 2	Homo sapiens	16-23
28247282-5	2017	Here, we report the 1H, 15N, 13CO, 13Calpha and 13Cbeta NMR chemical shift assignments of KLF41-130, which contains the KLF4 activation domain.	Hydrogen	20-22	Kruppel like factor 4	Homo sapiens	90-94
28263310-6	2017	SeP treatment impaired hydrogen-peroxide-induced adaptations through LRP1 in cultured myotubes and suppressed exercise-induced AMPK phosphorylation and Ppargc1a gene expression in mouse skeletal muscle-effects which were blunted in mice with a muscle-specific LRP1 deficiency.	Hydrogen	23-31	selenoprotein P	Mus musculus	0-3
16529492-7	2006	1H, 13C, and 31P NMR reveal that in an aqueous solution [Au(en)Cl2]+ bonds to guanosine 5"-monophosphate, 5"-GMP (1:1 mole ratio), via N7, although the stability is not very high.	Hydrogen	0-2	5'-nucleotidase, cytosolic II	Homo sapiens	109-112
28252287-8	2017	Hydrogen/deuterium exchange MS reveals that MRJP1 within these complexes is extensively disordered in the range of residues 20-265.	Hydrogen	0-8	major royal jelly protein 1	Apis mellifera	44-49
16507366-2	2006	To elucidate the molecular mechanism of the Keap1 and Nrf2 interaction, we resolved the six-bladed beta propeller crystal structure of the Kelch/DGR and CTR domains of mouse Keap1 and revealed that extensive inter- and intrablade hydrogen bonds maintain the structural integrity and proper association of Keap1 with Nrf2.	Hydrogen	230-238	kelch-like ECH-associated protein 1	Mus musculus	44-49
29354330-9	2017	Docking at on MDM2 suggested a hydrogen bond interaction between the 6-methoxy Tyr106, hydrophobic interaction with Val93, pi-pi stacking interactions with Tyr100 and His96 and hydrophobic interactions with Leu54 and Ile99.	Hydrogen	31-39	MDM2 proto-oncogene	Homo sapiens	14-18
16424336-1	2006	The quantum solid para-hydrogen (p-H2) has recently proven useful in matrix isolation spectroscopy.	Hydrogen	18-31	polyhomeotic homolog 2	Homo sapiens	33-37
28098910-0	2017	Hydrogen-rich saline improves non-alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARalpha and PPARgamma.	Hydrogen	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	133-142
16718587-0	2006	Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD).	Hydrogen	9-11	FKBP prolyl isomerase 8	Homo sapiens	76-82
16718587-0	2006	Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD).	Hydrogen	9-11	FKBP prolyl isomerase 8	Homo sapiens	84-93
28627348-0	2017	[Effect of hydrogen-rich water on the CD34 expression in lesion boundary brain tissue of rats with traumatic brain injury].	Hydrogen	11-19	CD34 molecule	Rattus norvegicus	38-42
28128831-5	2017	Through regulating the width n of the MX2 region in the MoS2/(MX2)n lateral heterostructures, the optical absorption of the lateral heterostructures under visible light can be increased, and the CBM and VBM states of the lateral heterostructures can be located above the hydrogen reduction potential and below the water oxidation potential, respectively.	Hydrogen	271-279	MX dynamin like GTPase 2	Homo sapiens	38-41
16651846-7	2006	Large neointimas of the HS group contained vimentin-positive and largely desmin- and h-caldesmon-negative cells.	Hydrogen	24-26	desmin	Oryctolagus cuniculus	73-79
28128831-5	2017	Through regulating the width n of the MX2 region in the MoS2/(MX2)n lateral heterostructures, the optical absorption of the lateral heterostructures under visible light can be increased, and the CBM and VBM states of the lateral heterostructures can be located above the hydrogen reduction potential and below the water oxidation potential, respectively.	Hydrogen	271-279	MX dynamin like GTPase 2	Homo sapiens	62-65
28116387-3	2017	We report that an Nepsilon-trimethyllysine analogue that contains the fluoromethyl group can be used as a 1H and 19F NMR probe for studies on TMLH catalysis.	Hydrogen	106-108	trimethyllysine hydroxylase, epsilon	Homo sapiens	142-146
16482924-8	2006	1H-MRS, in addition to CAG repeats analysis, might enable us to differentiate SCA6 from EA2, because the latter showed no decrease of NAA/Cr ratio in cerebellar hemisphere according to the previous reports.	Hydrogen	0-2	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	78-82
16252296-4	2005	Furthermore, the effect of binding on the Syk tSH2 structural dynamics was probed by hydrogen/deuterium exchange and electrospray mass spectrometry (ESI-MS).	Hydrogen	85-93	spleen associated tyrosine kinase	Homo sapiens	42-45
27870250-6	2017	Finally, we performed HDX-MS analysis of the NBD1 molecules and full-length K8, revealing hydrogen-bonding network changes accompanying complex formation.	Hydrogen	90-98	keratin 8	Homo sapiens	76-78
27744183-6	2017	Molecular modeling analysis indicated that hydrogen bonding to Thr120 and Thr124 beside hydrophobic interactions play effective role incorporating the active ligands to nAChR.	Hydrogen	43-51	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	169-174
27929190-0	2017	Mechanism and kinetics of tyrosinase inhibition by glycolic acid: a study using conventional spectroscopy methods and hydrogen/deuterium exchange coupling with mass spectrometry.	Hydrogen	118-126	tyrosinase	Homo sapiens	26-36
27929190-3	2017	Hydrogen/deuterium exchange coupling with mass spectrometry (HDX-MS) was used to elucidate the interaction mechanism between glycolic acid and tyrosinase.	Hydrogen	0-8	tyrosinase	Homo sapiens	143-153
27614324-6	2017	The interactions of aniline with TAL and PAL were mainly dominated by hydrogen bonds and electrostatic interactions.	Hydrogen	70-78	transaldolase 1	Homo sapiens	33-36
27847363-16	2017	The results suggest that other mechanisms for miR-H2 activity and for the repression of lytic gene expression during latency deserve investigation.	Hydrogen	50-52	membrane associated ring-CH-type finger 8	Homo sapiens	46-49
28169117-3	2017	In this work, we modified the 180  composite pulses, which are originally designed for spin 1/2 nuclei, for both indirect detection in 1H-{NOTDQ14}D-HMQC experiment and direct detection in one-pulse experiment, and found that the modified 180  composite pulses are useful for broadband excitation.	Hydrogen	135-137	spindlin 1	Homo sapiens	87-95
27926838-5	2016	Here we present a highly detailed structural and energetic map of the entire folding landscape of the leucine-rich repeat protein, pp32 (Anp32), obtained by combining pressure-dependent site-specific 1H-15N HSQC data with coarse-grained molecular dynamics simulations.	Hydrogen	200-202	acidic nuclear phosphoprotein 32 family member A	Homo sapiens	131-135
27080379-11	2016	TAP block allowed earlier re-establishment of gastrointestinal transit (11.2h in group I versus 8.1h in group II; P&lt;0.001).	Hydrogen	98-100	nuclear RNA export factor 1	Homo sapiens	0-3
27871033-6	2016	Docking of A1 with human mdm2 indicated the lowest binding energy (-6.111Kcal/mol) thereby showing strong affinity of the ligand molecule with the receptor which has been stabilized by strong hydrogen bond interactions in the binding pocket.	Hydrogen	192-200	MDM2 proto-oncogene	Homo sapiens	25-29
27705007-9	2016	Corresponding values for hs-cTnI were 5.3, 13.2 and 142.4%, whilst the RCV was -32.5-48.2% and the II was 0.10.	Hydrogen	25-27	troponin I3, cardiac type	Homo sapiens	28-32
27809489-7	2016	Amide hydrogen-deuterium exchange of PDH demonstrated changes in the structure of the enzyme upon dinucleotide binding.	Hydrogen	6-14	Photoreceptor dehydrogenase	Drosophila melanogaster	37-40
27840882-1	2016	Achiral supramolecular hydrogen bonded complexes between rod-like 4-(4-alkoxyphenylazo)pyridines and a taper shaped 4-substituted benzoic acid form achiral (Ia3[combining macron]d) and chiral "Im3[combining macron]m-type" bicontinuous cubic (I432) phases and a chiral isotropic liquid mesophase (Iso1[*]).	Hydrogen	23-31	eukaryotic translation initiation factor 1	Homo sapiens	296-300
27966325-0	2016	The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia reperfusion in rats.	Hydrogen	26-34	heme oxygenase 1	Rattus norvegicus	38-42
27966325-8	2016	RESULTS: Hydrogen significantly alleviated brain tissue histological damage, promoted HO-1 expression, upregulated levels of SOD, and decreased the levels of MDA in brain tissue after the ischemia reperfusion injury.	Hydrogen	9-17	heme oxygenase 1	Rattus norvegicus	86-90
27966325-9	2016	CONCLUSION: The results suggest that the neuroprotective effects of hydrogen may be mediated by promoting HO-1 expression and attenuated the oxidative injury.	Hydrogen	68-76	heme oxygenase 1	Rattus norvegicus	106-110
27711734-5	2016	When applied to a photocatalyst for H2 production from water containing methanol under simulated solar light, the layered titanate/P25 mixture showed considerably enhanced activity and the apparent quantum yield was 23% (at 320 nm).	Hydrogen	36-38	tubulin polymerization promoting protein	Homo sapiens	131-134
27792778-3	2016	To this end, we conduct a series of hydrogen bond propensity calculations in different contexts: 1) computational alanine-scanning studies of the MDM2-p53 interface; 2) the formation of the complex of MDM2 with the disruptive small molecule Nutlin-3a (dissecting the contribution of the different molecular fragments) and 3) the binding of a series of small molecules (drugs) with different affinities for MDM2.	Hydrogen	36-44	MDM2 proto-oncogene	Homo sapiens	201-205
27783615-3	2016	Furthermore, the role of NAD, which is affected by hydrogen partial pressure (PH2), has often not been considered.	Hydrogen	51-59	polyhomeotic homolog 2	Homo sapiens	78-81
27790986-2	2016	These enzymes feature a unique active site consisting of two spatially separated (by 11 A in PHM) and magnetically noncoupled copper centers that enables 1e- activation of O2 for hydrogen atom abstraction (HAA) of substrate C-H bonds and subsequent hydroxylation.	Hydrogen	179-187	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	93-96
29043009-1	2016	The electrochemical behavior of hydrogen oxidation on a platinum electrode in two aprotic room temperature ionic liquids (RTILs)-1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [Bmim][NTf2] and 1-butyl-1-methyl-pyrrolidinium bis(trifluoromethylsulfonyl)imide [Bmpy][NTf2]-was investigated in both anaerobic and aerobic conditions.	Hydrogen	32-40	nuclear transport factor 2	Homo sapiens	198-202
29043009-1	2016	The electrochemical behavior of hydrogen oxidation on a platinum electrode in two aprotic room temperature ionic liquids (RTILs)-1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [Bmim][NTf2] and 1-butyl-1-methyl-pyrrolidinium bis(trifluoromethylsulfonyl)imide [Bmpy][NTf2]-was investigated in both anaerobic and aerobic conditions.	Hydrogen	32-40	nuclear transport factor 2	Homo sapiens	280-284
29043009-7	2016	Furthermore, the overall rate of hydrogen oxidation is shown to be much higher in [Bmpy][NTf2] than that of [Bmim][NTf2], which is rationalized as the result of both higher solubility of hydrogen and the unique IL-electrode interface structure which promotes the hydrogen adsorption in [Bmpy][NTf2] than that of [Bmim][NTf2].	Hydrogen	33-41	nuclear transport factor 2	Homo sapiens	89-93
29043009-7	2016	Furthermore, the overall rate of hydrogen oxidation is shown to be much higher in [Bmpy][NTf2] than that of [Bmim][NTf2], which is rationalized as the result of both higher solubility of hydrogen and the unique IL-electrode interface structure which promotes the hydrogen adsorption in [Bmpy][NTf2] than that of [Bmim][NTf2].	Hydrogen	33-41	nuclear transport factor 2	Homo sapiens	115-119
29043009-7	2016	Furthermore, the overall rate of hydrogen oxidation is shown to be much higher in [Bmpy][NTf2] than that of [Bmim][NTf2], which is rationalized as the result of both higher solubility of hydrogen and the unique IL-electrode interface structure which promotes the hydrogen adsorption in [Bmpy][NTf2] than that of [Bmim][NTf2].	Hydrogen	33-41	nuclear transport factor 2	Homo sapiens	115-119
15950527-6	2005	Additionally, the 1H NMR spectra of P1 and P2, which were recorded under the same conditions, indicate that the silver (I) fragment reinforces pyrylium ring"s capacity to localize the formal positive charge within the heterocyclic ring.	Hydrogen	18-20	crystallin gamma F, pseudogene	Homo sapiens	36-45
31457152-8	2016	The computational studies revealed that the syn-[Zn(L)2] complex is stabilized by 9.7 kcal mol-1 more than that in the case of anti-[Zn(L)2] owing to the formation of hydrogen bonds between the two glucosyl moieties within the syn-complex.	Hydrogen	167-175	synemin	Homo sapiens	44-47
31457152-8	2016	The computational studies revealed that the syn-[Zn(L)2] complex is stabilized by 9.7 kcal mol-1 more than that in the case of anti-[Zn(L)2] owing to the formation of hydrogen bonds between the two glucosyl moieties within the syn-complex.	Hydrogen	167-175	synemin	Homo sapiens	227-230
27106210-0	2016	Erratum to: 1H, 13C and 15N resonance assignments of the Cdc42-binding domain of TOCA1.	Hydrogen	12-14	formin binding protein 1 like	Homo sapiens	81-86
16305252-4	2005	A linear correlation was observed between log k" (k" is the k2 value divided by the number of reactive hydrogens) and BDE and between log k2 and E(1/2)(Ru(VI/V)); the linearity in the former case supports a H-atom abstraction mechanism.	Hydrogen	103-112	homeobox D13	Homo sapiens	118-121
16285723-11	2005	On the basis of the hydrogen-bonding ability of Tyr176 substitutions that support the nonphotochemical C15-Z,syn to C15-Z,anti interconversion, we propose that Tyr176 orients the carboxyl side chain of a conserved acidic residue to stabilize protonation of the bilin chromophore.	Hydrogen	20-28	synemin	Homo sapiens	109-112
27599112-13	2016	While in the PdL2(2)-HSA system there are a hydrogen bond, a pi-cation and two T-shaped pi-pi interactions with ASB324, LYS212 and PHE228, respectively.	Hydrogen	44-52	programmed cell death 1 ligand 2	Homo sapiens	13-17
16157595-2	2005	To further elucidate the mechanistic basis for this stereocontrol we compared the stereoselectivity of the initiating hydrogen abstraction in soybean LOX-1 and an Ala542Gly mutant that converts linoleic acid to both 13S and 9R configuration hydroperoxide products.	Hydrogen	118-126	linoleate 9S-lipoxygenase-4	Glycine max	150-153
27386874-0	2016	Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-kappaB Expression.	Hydrogen	26-34	microRNA 21	Rattus norvegicus	131-137
16274242-12	2005	The low pH ionization, pK(H1), is perturbed by the Ala 79 mutation indicating that this ionization is modulated by the buried hydrogen bond network involving heme propionate D. The A79H73 variant has a high spin heme above pH 9 suggesting that the high pH ionization, pK(H2), involves a high spin heme conformer.	Hydrogen	126-134	relaxin 2	Homo sapiens	268-273
27685945-1	2016	We previously demonstrated that the sodium/hydrogen exchanger NHA2, also known as NHEDC2 or SLC9B2, is critical for insulin secretion by beta-cells.	Hydrogen	43-51	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	Mus musculus	82-88
16853724-0	2005	Weak hydrogen bonds as a structural motif for two-dimensional assemblies of oligopyridines on highly oriented pyrolytic graphite: an STM investigation.	Hydrogen	5-13	sulfotransferase family 1A member 3	Homo sapiens	133-136
27685945-1	2016	We previously demonstrated that the sodium/hydrogen exchanger NHA2, also known as NHEDC2 or SLC9B2, is critical for insulin secretion by beta-cells.	Hydrogen	43-51	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	Mus musculus	92-98
27685945-9	2016	In summary, our results demonstrate that loss of the sodium/hydrogen exchanger NHA2 exacerbates obesity- and aging-induced glucose intolerance in mice.	Hydrogen	60-68	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	Mus musculus	79-83
27782629-1	2016	We have experimentally performed the coherent control of delocalized ro-vibrational wave packets (RVWs) of solid para-hydrogen (p-H2) by the wave packet interferometry (WPI) combined with coherent anti-Stokes Raman scattering (CARS).	Hydrogen	113-126	polyhomeotic homolog 2	Homo sapiens	128-132
16192516-11	2005	The present study suggests that a proton pump inhibitor may be effective for prophylaxis of acid aspiration pneumonia in patients showing the full tolerance to H2 antagonists.	Hydrogen	160-162	ATPase H+/K+ transporting subunit alpha	Homo sapiens	34-45
27585936-0	2016	One barbiturate and two solvated thiobarbiturates containing the triply hydrogen-bonded ADA/DAD synthon, plus one ansolvate and three solvates of their coformer 2,4-diaminopyrimidine.	Hydrogen	72-80	adenosine deaminase	Homo sapiens	88-91
16040747-1	2005	The nature and the sites of interactions between anesthetic halothane and homodimeric Delta5-3-ketosteroid isomerase (KSI) are characterized by flexible ligand docking and confirmed by 1H-15N NMR.	Hydrogen	185-187	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	92-116
16040747-1	2005	The nature and the sites of interactions between anesthetic halothane and homodimeric Delta5-3-ketosteroid isomerase (KSI) are characterized by flexible ligand docking and confirmed by 1H-15N NMR.	Hydrogen	185-187	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	118-121
27585936-3	2016	Each of the compounds comprises two ADA hydrogen-bonding sites (D = donor and A = acceptor).	Hydrogen	40-48	adenosine deaminase	Homo sapiens	36-39
15963726-9	2005	The CoMFA and CoMSIA PLS contour maps and MOLCAD-generated active site electrostatic, lipophilicity, and hydrogen-bonding potential surface maps, as well as the docking studies, provided good insights into inhibitor-HDAC interactions at the molecular level.	Hydrogen	105-113	histone deacetylase 9	Homo sapiens	216-220
16201664-7	2005	A method is presented to calculate PH2 values along the flow direction in a PRB, and thus the maximum PH2 value that can possibly develop, assuming no bacterial utilization of the produced hydrogen.	Hydrogen	189-197	polyhomeotic homolog 2	Homo sapiens	35-38
27585936-4	2016	We report the results of cocrystallization experiments of barbituric acid and 2-thiobarbituric acid, respectively, with 2,4-diaminopyrimidine, which contains a complementary DAD hydrogen-bonding site and is therefore capable of forming an ADA/DAD synthon with barbituric acid and 2-thiobarbituric acid.	Hydrogen	178-186	adenosine deaminase	Homo sapiens	239-242
27350081-6	2016	The hydrolysis and interactions of the selected complexes with biomolecules (glutathione (GSH) and guanosine monophosphate (GMP)) were also studied by means of 1H NMR and ESI+ mass spectra.	Hydrogen	160-162	5'-nucleotidase, cytosolic II	Homo sapiens	99-129
16103375-1	2005	Proximal tubular reabsorption of filtered sodium by the sodium/hydrogen exchanger isoform 3 (NHE3), located on the apical membrane, is fundamental to the maintenance of systemic volume and pH homeostasis.	Hydrogen	63-71	solute carrier family 9 member A3	Homo sapiens	93-97
16103375-7	2005	Regulation of the interaction of NHE3 with the actin cytoskeleton can therefore provide a new mode of regulation of sodium and hydrogen transport.	Hydrogen	127-135	solute carrier family 9 member A3	Homo sapiens	33-37
16107153-3	2005	In aldose reductase, Leu300 forms a hydrogen bond through its main-chain nitrogen atom with the exocyclic amide group of the inhibitor, which when replaced with a Pro in aldehyde reductase, cannot form a hydrogen bond, thus causing a loss in binding energy.	Hydrogen	36-44	aldo-keto reductase family 1 member A1	Homo sapiens	170-188
16107153-3	2005	In aldose reductase, Leu300 forms a hydrogen bond through its main-chain nitrogen atom with the exocyclic amide group of the inhibitor, which when replaced with a Pro in aldehyde reductase, cannot form a hydrogen bond, thus causing a loss in binding energy.	Hydrogen	204-212	aldo-keto reductase family 1 member A1	Homo sapiens	170-188
27454459-8	2016	Further investigation of the binding site of GRA within the MMP9 molecule suggested that hydrophobic contacts, hydrogen bond formation and electrostatic interactions account for the binding of GRA.	Hydrogen	111-119	matrix metallopeptidase 9	Homo sapiens	60-64
16196902-4	2005	Complex surface reconstructions as reported in recent STM and LEED studies are observed only for cooling and H2 dosing.	Hydrogen	109-111	sulfotransferase family 1A member 3	Homo sapiens	54-57
15912545-1	2005	Gaseous HgH2, CdH2, and ZnH2 molecules were synthesized by the direct gas-phase reaction of excited mercury, cadmium, and zinc atoms with molecular hydrogen.	Hydrogen	148-156	cadherin 2	Homo sapiens	14-18
27484393-3	2016	The design employs transannular (intramolecular) hydrogen bonds (H-bonds), hitherto unstudied in pCps, between pseudo-ortho-positioned amides of a pCp-4,7,12,15-tetracarboxamide (pCpTA) to preorganize the molecules for intermolecular H-bonding with pi-stacked neighbors.	Hydrogen	49-57	Purkinje cell protein 4	Homo sapiens	147-152
27095675-0	2016	Ionic Hydrogen Bonds and Lipid Packing Defects Determine the Binding Orientation and Insertion Depth of RecA on Multicomponent Lipid Bilayers.	Hydrogen	6-14	RAD51 recombinase	Homo sapiens	104-108
16008355-0	2005	The role of hydrogen bond acceptor groups in the interaction of substrates with Pdr5p, a major yeast drug transporter.	Hydrogen	12-20	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	80-85
15998036-7	2005	1H NMR and crystallographic analysis of complexes 4 and 5 supported their TBP structures.	Hydrogen	0-2	TATA-box binding protein	Homo sapiens	74-77
27095675-8	2016	Ionic hydrogen bonds between the carboxylate group in phosphatidylserine and several lysine residues in the C-terminal region of RecA stabilize the parallel ( ) binding orientation, which is not locally stable on PG- and CL-containing membranes despite similarity in the overall charge density.	Hydrogen	6-14	RAD51 recombinase	Homo sapiens	129-133
27525951-8	2016	The glycopentalone was well mapped to CDK-2 and VEGFR-2 which involve six pharmacophore features (two hydrophobic centers and four hydrogen bond acceptors) and nine pharmacophore features (five hydrophobic, two hydrogen bond acceptors and two hydrogen bond donors), respectively.	Hydrogen	211-219	kinase insert domain receptor	Homo sapiens	48-55
15917145-7	2005	From the viewpoint of the structure-phototoxicity relationship, quinolones possessing the C-8 substituent with a fluorine or hydrogen and 1,8-naphthyridine derivative evoked phototoxicity in the mouse auricle.	Hydrogen	125-133	cell division cycle associated 3	Mus musculus	90-93
27525951-8	2016	The glycopentalone was well mapped to CDK-2 and VEGFR-2 which involve six pharmacophore features (two hydrophobic centers and four hydrogen bond acceptors) and nine pharmacophore features (five hydrophobic, two hydrogen bond acceptors and two hydrogen bond donors), respectively.	Hydrogen	211-219	kinase insert domain receptor	Homo sapiens	48-55
26678254-4	2016	A combination of liquid chromatography (LC), tandem mass spectrometry (MS/MS) and hydrogen-deuterium exchange studies confirmed GGT-1 mediated formation of the 607.2 and 525.2 m/z (M + H)(+) ions corresponding to bis(cys-gly)-MDI and bis(cys-gly)-HDI, respectively, the cleavage products expected from the corresponding bis(GSH)-diisocyanate conjugates.	Hydrogen	82-90	gamma-glutamyltransferase 1	Homo sapiens	128-133
15747319-3	2005	However, in the case of Z-Gly-2Pyg-Gly-OMe, the intramolecular hydrogen bonding between 2Pyg-NH and the pyridine nitrogen was not observed, whereas Z-Aib-2Pyg-Aib-OMe adopts a unique conformation with an intramolecular hydrogen bond between 2Pyg-NH and a pyridine nitrogen.	Hydrogen	219-227	ANIB1	Homo sapiens	150-153
15747319-3	2005	However, in the case of Z-Gly-2Pyg-Gly-OMe, the intramolecular hydrogen bonding between 2Pyg-NH and the pyridine nitrogen was not observed, whereas Z-Aib-2Pyg-Aib-OMe adopts a unique conformation with an intramolecular hydrogen bond between 2Pyg-NH and a pyridine nitrogen.	Hydrogen	219-227	ANIB1	Homo sapiens	159-162
27374698-6	2016	The results obtained provide experimental support for the strength of hydrogen bonds between the alcohols and the NTf2 and PF6 anions, providing insights into the IL intermolecular interactions, namely by indicating the ability of the alcohols to discriminate the IL anion hydrogen bond basicity.	Hydrogen	70-78	nuclear transport factor 2	Homo sapiens	114-118
26378461-2	2016	In the present work, the multireference characters of the transition states and the forming and breaking of bonds for a large set of hydrogen abstraction reactions from phenolic compounds by peroxyl radicals have been analyzed using the T1, M, B1, and GB1 diagnostics.	Hydrogen	133-141	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	252-255
15968678-0	2005	1H MRS-visible lipids accumulate during apoptosis of lymphoma cells in vitro and in vivo.	Hydrogen	0-2	sterile alpha motif domain containing 11	Mus musculus	3-6
27311877-0	2016	Hydrogenation and Transfer Hydrogenation Promoted by Tethered Ru-S Complexes: From Cooperative Dihydrogen Activation to Hydride Abstraction/Proton Release from Dihydrogen Surrogates.	Hydrogen	95-105	RUS family member 1	Homo sapiens	62-66
16237980-0	2005	[Brain metabolism alterations in patients with anorexia nervosa observed in 1H-MRS].	Hydrogen	76-78	MROS	Homo sapiens	79-82
16237980-2	2005	The purpose of this study was to use the 1H-MRS method in investigating metabolic changes in the brain of patients with anorexia nervosa.	Hydrogen	41-43	MROS	Homo sapiens	44-47
16237980-4	2005	1H-MRS was acquired by the method of single voxels in white and grey matter.	Hydrogen	0-2	MROS	Homo sapiens	3-6
27337388-1	2016	A theoretical study at the level of density functional theory (DFT) was performed to characterize noncovalent intermolecular interactions, especially hydrogen bond interactions, in the active site of enzyme human androsterone sulphotransferase (SULT2A1/ADT).	Hydrogen	150-158	sulfotransferase family 2A member 1	Homo sapiens	245-252
16833878-3	2005	According to quantum mechanical calculations, TBP (modeled by trimethyl phosphate TMP) displays stronger hydrogen-bonding interactions with HNO3 than with H2O, and this has been modeled in force-field calculations.	Hydrogen	105-113	TATA-box binding protein	Homo sapiens	46-49
27061981-9	2016	Molecular docking studies using a homology model of 5-HT2A revealed a significant role of hydrogen bonds between both thiourea NH groups and Asp155/Tyr370 residues, as well as pi-pi interaction with Phe339.	Hydrogen	90-98	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	52-58
15845357-9	2005	Although the overall structures of the three enzymes are quite similar to each other, some subtle difference around their active sites that distinguishes cathepsin-E from cathepsin-D and BACE1 has been revealed through an analysis of hydrogen bond network and microenvironment.	Hydrogen	234-242	cathepsin E	Homo sapiens	154-165
27306006-5	2016	Furthermore, the size dependence of the parameter was thought to reflect the evolution of the hydrogen-bond structure of H3O(+)(H2O)n with the cluster size.	Hydrogen	94-102	H3 clustered histone 15	Homo sapiens	121-124
15847432-4	2005	In solution, the 1H and 13C NMR spectra revealed a two-site fluxional behavior for the carbamato ligands between 0 degrees C and 25 degrees C that is consistent with a bridge-mode isomerization relating the syn-syn-mu(1,3) form and an alternative syn-anti-mu(1,1) form.	Hydrogen	17-19	synemin	Homo sapiens	207-210
26945701-7	2016	Here, we review the challenges impeding efforts to offer an effective treatment against H2 S intoxication using agents that trap free H2 S, and present novel pharmacological approaches aimed at correcting some of the most harmful consequences of H2 S intoxication.	Hydrogen	134-136	TRAP	Homo sapiens	124-128
15802613-2	2005	GPx-1 is ubiquitously expressed in eukaryotic cells where it reduces hydrogen and lipid peroxides to alcohols.	Hydrogen	69-77	glutathione peroxidase 1	Homo sapiens	0-5
15795260-9	2005	The properties of H2, however, are very similar to those recently reported for the A28 protein.	Hydrogen	18-20	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	83-86
15795260-10	2005	Moreover, coimmunoprecipitation experiments indicated an interaction between H2 and A28.	Hydrogen	77-79	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	84-87
15496139-4	2005	This proton transfer suggests that hydrogen bonding between ferrochelatase and mesoporphyrin is a key factor in the thermodynamics of the binding reaction.	Hydrogen	35-43	ferrochelatase	Mus musculus	60-74
15708379-4	2005	These relationships are demonstrated by calculating standard transformed Gibbs energies of reaction and the changes in binding of hydrogen ions at pHs 5-9 of a number of oxidoreductase, transferase, hydrolase, and ligase reactions by use of the data base BasicBiochemData2 and its recent extensions.	Hydrogen	130-138	thioredoxin reductase 1	Homo sapiens	170-184
15836040-0	2005	The binding of 4He and 3He to a hydrogen molecule: a computational study for pH2 and oH2.	Hydrogen	32-40	polyhomeotic homolog 2	Homo sapiens	77-80
15721253-6	2005	Mutations designed to reduce the size of the SF-1 pocket or to disrupt hydrogen bonds with the phospholipid abolish SF-1/coactivator interactions and significantly reduce SF-1 transcriptional activity.	Hydrogen	71-79	splicing factor 1	Homo sapiens	116-120
15721253-6	2005	Mutations designed to reduce the size of the SF-1 pocket or to disrupt hydrogen bonds with the phospholipid abolish SF-1/coactivator interactions and significantly reduce SF-1 transcriptional activity.	Hydrogen	71-79	splicing factor 1	Homo sapiens	116-120
15644221-8	2005	Interestingly, the total number of hydrogen bonds and salt bridges contributed by hot spots is as expected.	Hydrogen	35-43	alcohol dehydrogenase iron containing 1	Homo sapiens	82-85
27125576-2	2016	Herein we report a facile synthetic approach to cobalt nanocrystal assembled hollow nanoparticles (Co-HNP), which serve as an electrocatalyst for hydrogen generation from neutral-pH water.	Hydrogen	146-154	kallikrein related peptidase 8	Homo sapiens	102-105
27125576-4	2016	The Co-HNP/CC electrode retains its high activity after 20 h hydrogen generation at a high current density of 150 mA cm(-2) , indicating the superior activity and stability of Co-HNP as electrocatalyst.	Hydrogen	61-69	kallikrein related peptidase 8	Homo sapiens	7-10
27125576-4	2016	The Co-HNP/CC electrode retains its high activity after 20 h hydrogen generation at a high current density of 150 mA cm(-2) , indicating the superior activity and stability of Co-HNP as electrocatalyst.	Hydrogen	61-69	kallikrein related peptidase 8	Homo sapiens	179-182
16839103-10	2005	The intramolecular hydrogen bond in OO-s-cis glycolaldehyde is found to be responsible for the discrepancies between SAR and experimental rate coefficients.	Hydrogen	19-27	sarcosine dehydrogenase	Homo sapiens	117-120
27082784-9	2016	Our studies also revealed differing dynamics of the hydrogen bonds between CBP-R646 and c-Myb-E306 and between CBP-E665 and c-Myb-R294 caused by the CBP KIX mutations.	Hydrogen	52-60	CREB binding protein	Mus musculus	75-78
27082784-10	2016	In the wild-type CBP:c-Myb complex, both of the hydrogen bonds stayed relatively stable.	Hydrogen	48-56	CREB binding protein	Mus musculus	17-20
27082784-11	2016	In contrast, in the mutant CBP:c-Myb complex, hydrogen bonds between R646 and E306 showed an increasing trend followed by a decreasing trend, and hydrogen bonds of the E665:R294 pair exhibited a fast decreasing trend over time during MD simulations.	Hydrogen	46-54	CREB binding protein	Mus musculus	27-30
27082784-11	2016	In contrast, in the mutant CBP:c-Myb complex, hydrogen bonds between R646 and E306 showed an increasing trend followed by a decreasing trend, and hydrogen bonds of the E665:R294 pair exhibited a fast decreasing trend over time during MD simulations.	Hydrogen	146-154	CREB binding protein	Mus musculus	27-30
15642166-6	2005	We also quantified the sub-G1 peak area and the ratio of the CH2/CH3 peak area of the cell membrane in BC-M1 cells by flow cytometry and 1H-NMR spectra, respectively.	Hydrogen	137-139	CD48 molecule	Homo sapiens	103-108
26974875-7	2016	In addition to the loss of the hydrogen bond between Gln36 of CK2alpha and Gly189 of Pc in the two mutants, the improper recognition mechanisms occurred through different pathways.	Hydrogen	31-39	casein kinase 2 alpha 2	Homo sapiens	62-70
16075810-5	2005	Results show that Stx2 regulates the passage of water through the HRTEC within an incubation period of 1h.	Hydrogen	103-105	syntaxin 2	Homo sapiens	18-22
26861138-0	2016	1H, 15N and 13C assignments of the N-terminal domain of the Mediator complex subunit MED26.	Hydrogen	0-2	mediator complex subunit 26	Homo sapiens	85-90
15606183-0	2004	Unique hydrogen bonding correlating with a reduced band gap and phase transition in the hybrid perovskites (HO(CH2)2NH3)2PbX4 (X = I, Br).	Hydrogen	7-15	PBX homeobox 4	Homo sapiens	121-125
25995077-0	2016	Demonstration of glucose-6-phosphate hydrogen 5 enrichment from deuterated water by transaldolase-mediated exchange alone.	Hydrogen	37-45	transaldolase 1	Homo sapiens	84-97
15469931-7	2004	The most remarkable features of DES interaction with TTR are its hydrophobic interactions within the protein halogen binding pockets, where its ethyl groups are snugly fitted, and the hydrogen bonds established at the center of the tetramer with Ser-117.	Hydrogen	184-192	transthyretin	Homo sapiens	53-56
15568804-8	2004	An increase in preference for charged residues at P"1 in pepsin-A mutants might have been due to an increase in the hydrogen-bonding interactions.	Hydrogen	116-124	pepsinogen A5	Homo sapiens	57-65
15501569-4	2004	All the acquired spectral data showed that a new adduct between Echi and Gua was formed, and two pairs of adjacent intermolecular hydrogen bonds between the Ala backbone atoms in Echi and Gua (Ala-NH to Gua-N3 and Gua-NH2 to Ala-CO) played a dominating role in the interaction.	Hydrogen	130-138	DExD-box helicase 21	Homo sapiens	188-191
15501569-4	2004	All the acquired spectral data showed that a new adduct between Echi and Gua was formed, and two pairs of adjacent intermolecular hydrogen bonds between the Ala backbone atoms in Echi and Gua (Ala-NH to Gua-N3 and Gua-NH2 to Ala-CO) played a dominating role in the interaction.	Hydrogen	130-138	DExD-box helicase 21	Homo sapiens	188-191
15501569-4	2004	All the acquired spectral data showed that a new adduct between Echi and Gua was formed, and two pairs of adjacent intermolecular hydrogen bonds between the Ala backbone atoms in Echi and Gua (Ala-NH to Gua-N3 and Gua-NH2 to Ala-CO) played a dominating role in the interaction.	Hydrogen	130-138	DExD-box helicase 21	Homo sapiens	214-231
15474353-2	2004	We show by 1H-NMR spectroscopy that TPPP/p25 is natively unfolded.	Hydrogen	11-13	tubulin polymerization promoting protein	Homo sapiens	36-44
15481984-7	2004	The electron density of derivative 28 bound to chicken PARP-1 revealed that the oxime makes a tight hydrogen bond with the catalytic gamma-carboxylate of glutamic acid (Glu) 988 in accordance with our original designs and models.	Hydrogen	100-108	poly(ADP-ribose) polymerase 1	Gallus gallus	55-61
15557806-0	2004	1H, 13C and 15N resonance assignments of the C-terminal BRCT domain from human BRCA1.	Hydrogen	0-2	BRCA1 DNA repair associated	Homo sapiens	79-84
15476952-7	2004	The solution structure of URP has been determined by 1H NMR spectroscopy and molecular dynamics.	Hydrogen	53-55	urotensin 2B	Rattus norvegicus	26-29
15514768-0	2004	LZnX complexes of tripodal ligands with intramolecular RN-H hydrogen bonding groups: structural implications of a hydrogen bonding cavity, and of X/R in the hydrogen bonding geometry/strength.	Hydrogen	60-68	ribonuclease/angiogenin inhibitor 1	Homo sapiens	55-59
15305215-4	2004	On the other hand, the peptide Z-Aib-2Dpy-Aib-OMe probably adopts a beta-turn structure which is stabilized by two intramolecular hydrogen bonds between 2Dpy-NH and a pyridine nitrogen and between AA3-NH and the C=O of the Z group.	Hydrogen	130-138	ANIB1	Homo sapiens	33-36
15305215-4	2004	On the other hand, the peptide Z-Aib-2Dpy-Aib-OMe probably adopts a beta-turn structure which is stabilized by two intramolecular hydrogen bonds between 2Dpy-NH and a pyridine nitrogen and between AA3-NH and the C=O of the Z group.	Hydrogen	130-138	ANIB1	Homo sapiens	42-45
15266650-8	2004	On the other hand, H2, a mAb antikinesin KIF5A, exhibited only random immunofluorescence labeling in axoplasm, as was also the case with pAb antidynein heavy chain immunofluorescence.	Hydrogen	19-21	kinesin family member 5A	Rattus norvegicus	41-46
15273299-9	2004	For PQQH--&gt;PQQH2, migration of H5 to the C4 oxygen may be assisted by a weak base like water (either by crystal water Wat97 or bulk solvent, hydrogen-bonded to Glu 171-CO2- in MDH and by Wat89 in sGDH).	Hydrogen	144-152	malate dehydrogenase 2	Homo sapiens	179-182
15222753-3	2004	Analyses of the trajectories revealed that in the cysteine-phosphor complex of PTP1B, Gln262 oscillates freely between the bound phosphate group and Gly259 frequently forming, as observed in the crystal structure, a hydrogen bond with the backbone oxygen of Gly259.	Hydrogen	216-224	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	79-84
15213445-0	2004	1H, 13C and 15N resonance assignments of the conserved core of hAsf1 A.	Hydrogen	0-2	anti-silencing function 1A histone chaperone	Homo sapiens	63-70
15213466-0	2004	1H, 13C and 15N resonance assignments and the secondary structures of human coactosin like protein (hCLP) D123N.	Hydrogen	0-2	coactosin like F-actin binding protein 1	Homo sapiens	100-104
15125839-5	2004	In addition to the polymerization motif that was previously identified in the Rad51 proteins, we found another hydrogen bonding interaction at the polymer interface, which could explain why Dmc1 forms stable octameric rings instead of helical filaments.	Hydrogen	111-119	RAD51 recombinase	Homo sapiens	78-83
15125839-5	2004	In addition to the polymerization motif that was previously identified in the Rad51 proteins, we found another hydrogen bonding interaction at the polymer interface, which could explain why Dmc1 forms stable octameric rings instead of helical filaments.	Hydrogen	111-119	DNA meiotic recombinase 1	Homo sapiens	190-194
15131304-4	2004	Given this structure, it is likely that dioxygen is directly involved in the electron transfer and hydrogen abstraction steps of the PHM reaction.	Hydrogen	99-107	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	133-136
15225751-2	2004	The crystal structure of a deletion mutant (Delta165-215) of the VDR ligand-binding domain (LBD) bound to 1,25(OH)(2)D(3) indicates that amino acid residues tyrosine-143 and serine-278 form hydrogen bonding interactions with the 3-hydroxyl group of 1,25(OH)(2)D(3).	Hydrogen	190-198	vitamin D receptor	Homo sapiens	65-68
14722075-4	2004	In contrast to the 3-hydroxyl of cholesterol, the 3-O-sulfate group makes additional direct hydrogen bonds with three residues of the RORalpha ligand binding domain, namely NH-Gln(289), NH-Tyr(290), and NH1-Arg(370).	Hydrogen	92-100	RAR related orphan receptor A	Homo sapiens	134-142
14722099-5	2004	The C-terminal extension of beta7/Pre4, which forms several hydrogen bonds with beta1/Pre3, is in addition required for the post-acidic activity mediated by the latter subunit.	Hydrogen	60-68	proteasome core particle subunit beta 1	Saccharomyces cerevisiae S288C	86-90
14980826-4	2004	Polymer chains zigzag along the b-axis and directly connect to each other by N-2...O-6 hydrogen bonds.	Hydrogen	87-95	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	83-86
14980826-6	2004	The iodide ions stabilized the salt structure by forming hydrogen bonds with the N-2 and O-6 atoms of the polymer chains together with an electrostatic interaction between N-2 and the iodide ions.	Hydrogen	57-65	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	89-92
15004377-0	2004	rac-1-Phenylethylammonium carboxymethylphosphonate(1-): hydrogen-bonded anion sheets with pendent cations.	Hydrogen	56-64	Rac family small GTPase 1	Homo sapiens	0-5
15042412-0	2004	1H NMR relaxation times of skeletal muscle metabolites at 3 T. This study reports proton relaxation times of water and metabolites in soleus and tibialis anterior muscles of young healthy volunteers at 3 T. The results are in agreement with data reported for 1.5 and 4 T, showing a steady increase of spin-lattice relaxation times of water, creatine and lipids with B(0) and no effect of B(0) on spin-spin relaxation.	Hydrogen	0-2	spindlin 1	Homo sapiens	301-305
15042412-0	2004	1H NMR relaxation times of skeletal muscle metabolites at 3 T. This study reports proton relaxation times of water and metabolites in soleus and tibialis anterior muscles of young healthy volunteers at 3 T. The results are in agreement with data reported for 1.5 and 4 T, showing a steady increase of spin-lattice relaxation times of water, creatine and lipids with B(0) and no effect of B(0) on spin-spin relaxation.	Hydrogen	0-2	spindlin 1	Homo sapiens	396-400
15042412-0	2004	1H NMR relaxation times of skeletal muscle metabolites at 3 T. This study reports proton relaxation times of water and metabolites in soleus and tibialis anterior muscles of young healthy volunteers at 3 T. The results are in agreement with data reported for 1.5 and 4 T, showing a steady increase of spin-lattice relaxation times of water, creatine and lipids with B(0) and no effect of B(0) on spin-spin relaxation.	Hydrogen	0-2	spindlin 1	Homo sapiens	396-400
14764100-12	2004	In thermal denaturation experiments, Bt-Lon was found to display an indicator of thermostability value, Tm of 71.5 degrees C. Sequence comparison with mesophilic Lon proteases shows differences in the rigidity, electrostatic interactions, and hydrogen bonding of Bt-Lon relevant to thermostability.	Hydrogen	243-251	putative ATP-dependent Lon protease	Escherichia coli	40-43
25995077-9	2016	CONCLUSION: Hydrogen 5 of G6P was enriched from (2)H2O through exchanges mediated by transaldolase.	Hydrogen	12-20	transaldolase 1	Homo sapiens	85-98
14670455-5	2004	The corrected values of the dissociation energy at the SCF and MP2 levels and B3LYP calculations are indicative of relatively strong OH...O hydrogen-bonded interaction.	Hydrogen	140-148	KIT ligand	Homo sapiens	55-58
26700245-4	2016	The competition binding assay and PAC1 site-specific mutation of Asp116, which formed two hydrogen bonds with Dox, confirmed the binding of doxycycline to PAC1 imitating PACAP(30-37).	Hydrogen	90-98	adenylate cyclase activating polypeptide 1 receptor 1	Mus musculus	155-159
14670455-6	2004	The changes in the vibrational characteristics (vibrational frequencies and infrared intensities) arising from the hydrogen bonding between HONO2 and H2O have been estimated by using the ab initio calculations at SCF and MP2 levels and B3LYP/6-31G(d,p) calculations.	Hydrogen	115-123	KIT ligand	Homo sapiens	213-216
26786101-5	2016	A network of AQP4 loop D hydrogen bonding interactions, identified using molecular dynamics simulations and based on a comparative mutagenic analysis of AQPs 1, 3, and 4, suggest that loop D interactions may provide a general structural framework for tetrameric assembly within the AQP family.	Hydrogen	25-33	aquaporin 4	Homo sapiens	13-17
14682765-0	2003	Preparation of syn-delta-hydroxy-beta-amino esters via an intramolecular hydrogen bond directed diastereoselective hydrogenation.	Hydrogen	73-81	synemin	Homo sapiens	15-18
14682765-2	2003	Hydrogenation of delta-hydroxy-beta-ketoester-derived enamines 8 produces syn-delta-hydroxy-beta-amino esters 9 diastereoselectively, which may be directed by the formation of an intramolecular hydrogen bond between the delta-hydroxyl and beta-amino groups.	Hydrogen	194-202	synemin	Homo sapiens	74-77
27010853-8	2016	Collectively, our data revealed that NHA1 and NHA2 function as a key sodium-hydrogen exchanger responsible for sperm motility after leaving the cauda epididymidis.	Hydrogen	76-84	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	Mus musculus	46-50
26797122-9	2016	The critical role for possible hydrogen bond interaction at apoA-I Tyr(166) was further supported using reconstituted HDL generated from apoA-I mutants (Tyr(166)   Glu or Asn), which showed preservation in both LCAT binding affinity and catalytic efficiency.	Hydrogen	31-39	lecithin-cholesterol acyltransferase	Homo sapiens	211-215
14566877-13	2003	Cyclam NH hydrogen bonding is prevalent both in the solid state and in solution, and is relevant to the anti-HIV activity of Zn(II) and other metal cyclam complexes and to their ability to recognize the CXCR4 transmembrane co-receptor.	Hydrogen	10-18	C-X-C motif chemokine receptor 4	Homo sapiens	203-208
26784023-4	2016	Such features render PtCuNi/CNF@CF as an ideal binder-free HER electrode for hydrogen production.	Hydrogen	77-85	NPHS1 adhesion molecule, nephrin	Homo sapiens	28-31
14501117-8	2003	A number of additional hydrogen bonds between the two domains in the N and C lobes have been identified in the structure of hST compared with that of hOT, which indicate a greater compactness of the lobes of hST than those of hOT.	Hydrogen	23-31	alcohol dehydrogenase iron containing 1	Homo sapiens	150-153
14501117-8	2003	A number of additional hydrogen bonds between the two domains in the N and C lobes have been identified in the structure of hST compared with that of hOT, which indicate a greater compactness of the lobes of hST than those of hOT.	Hydrogen	23-31	alcohol dehydrogenase iron containing 1	Homo sapiens	226-229
26613247-4	2016	Solution NMR structure of the ternary complex of human I-BABP with glycocholate and glycochenodeoxycholate reveals an extensive network of hydrogen bonds and hydrophobic interactions stabilizing the bound bile salts.	Hydrogen	139-147	fatty acid binding protein 6	Homo sapiens	55-61
14555798-3	2003	Because of the competition of Pr(III) for ligands with Ca(II), the percentages of free Ca2+, [Ca(Lac)], and [Ca(His)(Thr)H3] increase gradually and the percentages of CaHPO4(aq) and [Ca(Cit)(His)H2] decrease gradually with the increase in the total concentration of Pr(III).	Hydrogen	195-197	carbonic anhydrase 2	Homo sapiens	55-61
26785931-4	2016	Dynamic analysis of TraF by time-resolved hydrogen-deuterium exchange revealed that the C-terminal region containing the predicted thioredoxin-like domain is quite structured, while the N-terminal region, predicted to interact with TraH in the intact F-T4SS, was more dynamic.	Hydrogen	42-50	conjugal pilus assembly protein TraF	Escherichia coli	20-24
26743504-6	2016	IMD 1nmol L(-1), applied either throughout ischaemia (3h) and re-oxygenation (1h) or during re-oxygenation (1h) alone, attenuated HCM injury (P&lt;0.05); cell viabilities were 59% and 61% respectively vs. 39% in absence of IMD.	Hydrogen	78-80	Bruton tyrosine kinase	Homo sapiens	0-5
14525355-0	2003	Measurements of GnE/GnM from the 2H(e--&gt;,en--&gt;)1H Reaction to Q2=1.45 (GeV/c)2.	Hydrogen	53-55	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	16-19
26743504-6	2016	IMD 1nmol L(-1), applied either throughout ischaemia (3h) and re-oxygenation (1h) or during re-oxygenation (1h) alone, attenuated HCM injury (P&lt;0.05); cell viabilities were 59% and 61% respectively vs. 39% in absence of IMD.	Hydrogen	108-110	Bruton tyrosine kinase	Homo sapiens	0-5
27432661-1	2016	Proton magnetic resonance spectroscopy (1H MRS) is a noninvasive imaging technique that can easily be added to the conventional magnetic resonance (MR) imaging sequences.	Hydrogen	40-42	MROS	Homo sapiens	43-46
12952461-11	2003	Our studies demonstrate that the furanoid epsilon-SAA III is able to introduce an unusual intraresidue hydrogen bond-stabilized beta-turn-like conformation in two of the three cyclic structures.	Hydrogen	103-111	serum amyloid A1 cluster	Homo sapiens	50-53
14525498-2	2003	The static susceptibility is described by the spin S=1/2 antiferromagnetic triangular-lattice Heisenberg model with the exchange constant J approximately 250 K. Regardless of the large magnetic interactions, the 1H NMR spectra show no indication of long-range magnetic ordering down to 32 mK, which is 4 orders of magnitude smaller than J.	Hydrogen	212-214	spindlin 1	Homo sapiens	46-50
25933061-6	2016	Moreover, the formed important hydrogen bonds of Tyr1203 residue with XVA939 and WAT1551 with ISX enhance stabilities of the complexes, and the electrostatic interactions in XAV939-TNKS1 and van der Waals interactions in ISX-TNKS1 system are main driving forces for affinity.	Hydrogen	31-39	intestine specific homeobox	Homo sapiens	94-97
26681795-4	2016	The structure of the liganded VDR/RXR complex was recently characterized using cryoelectron microscopy, X-ray scattering, and hydrogen deuterium exchange.	Hydrogen	126-134	vitamin D receptor	Homo sapiens	30-33
12878844-0	2003	Backbone 1H, 13C, and 15N resonance assignments for the 21 kDa GTPase Rac1 complexed to GDP and Mg2+.	Hydrogen	9-11	Rac family small GTPase 1	Homo sapiens	70-74
26681795-4	2016	The structure of the liganded VDR/RXR complex was recently characterized using cryoelectron microscopy, X-ray scattering, and hydrogen deuterium exchange.	Hydrogen	126-134	retinoid X receptor alpha	Homo sapiens	34-37
26827960-1	2016	The Arg274 residue of the ligand binding domain of human vitamin D receptor (hVDR) is important for 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3) binding as a specific ligand through forming a hydrogen bond with the 1alpha-OH group of the active vitamin D3, 1alpha,25(OH)2D3.	Hydrogen	196-204	vitamin D receptor	Homo sapiens	57-75
12842861-11	2003	As a functional correlate of increased 11betaHSD-2 expression in colon, the GR-stimulated sodium-hydrogen exchanger NHE-3 was lowered by NaCl restriction.	Hydrogen	97-105	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	39-50
12860429-10	2003	By contrast, the packing structure of form II is a head-to-head channel that is stabilized at both O-2/O-3 and O-6 sides of each beta-CD by direct O(CD)...O(CD) and indirect O(CD)...O(W)...(O(W))...O(CD) hydrogen bonds.	Hydrogen	204-212	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	99-114
26827960-1	2016	The Arg274 residue of the ligand binding domain of human vitamin D receptor (hVDR) is important for 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3) binding as a specific ligand through forming a hydrogen bond with the 1alpha-OH group of the active vitamin D3, 1alpha,25(OH)2D3.	Hydrogen	196-204	vitamin D receptor	Homo sapiens	77-81
26627307-7	2015	Owing to the intrinsic hydrophobic properties of the organic phase and the hydrogen bonding-forming ability of the carboxyl group of Boc-7, the phase separation system captures and releases Sudan Red, fluorescein, and streptavidin in a controllable manner.	Hydrogen	75-83	BOC cell adhesion associated, oncogene regulated	Homo sapiens	133-136
12834348-5	2003	Gln 192 from FXa forms a hydrogen bond with the P2 carbonyl group of ecotin.	Hydrogen	25-33	coagulation factor X	Homo sapiens	13-16
26529388-8	2015	Addition of chemical blockers indicated that hydrogen bondings and disulfide bridges were the main mechanisms of interactions with mucin.	Hydrogen	45-53	solute carrier family 13 member 2	Rattus norvegicus	131-136
12888261-13	2003	Therefore, we theorize that use of an H2 selective antihistamine will reverse this polarization back to a Th1 type response and therefore improve immune function of the frail elderly.	Hydrogen	38-40	negative elongation factor complex member C/D	Homo sapiens	106-109
26061299-7	2015	We also examined the structural basis and non-bonded profile of TACE interaction with a designed peptide hydroxamic acid inhibitor, and found that the inhibitor ligand is tightly buried in the active pocket of TACE, forming a number of hydrogen bonds, hydrophobic forces and van der Waals contacts at the interaction interface, conferring both stability and specificity for TACE-inhibitor complex architecture.	Hydrogen	236-244	ADAM metallopeptidase domain 17	Homo sapiens	64-68
12797802-3	2003	The one having l-Ala-1 adopted trans-cis-trans-trans-trans-trans (t-c-t-t-t-t) amide configurations in the crystal, a type-VI beta-turn for residues 1-4 stabilized by one intramolecular hydrogen bond between Ala-4 NH and l-Ala-1 C = O, and in CDCl(3) existed as a mixture of six conformers, of which the major conformer was very similar to that in the crystal, but quite different from that of RA-VII in solution.	Hydrogen	186-194	lymphocyte antigen 6 complex	Mus musculus	17-22
26061299-7	2015	We also examined the structural basis and non-bonded profile of TACE interaction with a designed peptide hydroxamic acid inhibitor, and found that the inhibitor ligand is tightly buried in the active pocket of TACE, forming a number of hydrogen bonds, hydrophobic forces and van der Waals contacts at the interaction interface, conferring both stability and specificity for TACE-inhibitor complex architecture.	Hydrogen	236-244	ADAM metallopeptidase domain 17	Homo sapiens	210-214
26061299-7	2015	We also examined the structural basis and non-bonded profile of TACE interaction with a designed peptide hydroxamic acid inhibitor, and found that the inhibitor ligand is tightly buried in the active pocket of TACE, forming a number of hydrogen bonds, hydrophobic forces and van der Waals contacts at the interaction interface, conferring both stability and specificity for TACE-inhibitor complex architecture.	Hydrogen	236-244	ADAM metallopeptidase domain 17	Homo sapiens	210-214
26426584-6	2015	The as-obtained mpg-C3N4/CNT/1% NiS ternary composite photocatalyst exhibits the best H2-evolution activity with the highest rate of about 521 mumol g(-1) h(-1) under visible light (lambda&gt;= 420 nm), which is almost 148 times that of a pure mpg-C3N4/CNT sample.	Hydrogen	86-88	solute carrier family 28 member 1	Homo sapiens	25-30
12797802-3	2003	The one having l-Ala-1 adopted trans-cis-trans-trans-trans-trans (t-c-t-t-t-t) amide configurations in the crystal, a type-VI beta-turn for residues 1-4 stabilized by one intramolecular hydrogen bond between Ala-4 NH and l-Ala-1 C = O, and in CDCl(3) existed as a mixture of six conformers, of which the major conformer was very similar to that in the crystal, but quite different from that of RA-VII in solution.	Hydrogen	186-194	lymphocyte antigen 6 complex	Mus musculus	223-228
26332643-1	2015	Insights into the mechanism of the unusual trans-hydrogenation of internal alkynes catalyzed by {Cp*Ru} complexes were gained by para-hydrogen (p-H2 ) induced polarization (PHIP) transfer NMR spectroscopy.	Hydrogen	129-142	polyhomeotic homolog 2	Homo sapiens	144-148
12676236-5	2003	Hydrogen bond strength in the hexamer decreases in the order: boat, cyclic, book, cage and prism.	Hydrogen	0-8	ataxin 1 like	Homo sapiens	62-66
26117323-0	2015	Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice.	Hydrogen	10-18	low density lipoprotein receptor	Mus musculus	56-88
26117323-3	2015	Low-density lipoprotein receptor-knockout (LDLR(-/-)) mice fed an atherogenic diet were dosed daily with H(2) and/or simvastatin.	Hydrogen	105-109	low density lipoprotein receptor	Mus musculus	0-32
25820467-9	2015	We found that H2 clearly inhibited hyperalgesia and allodynia in neuropathic pain and also attenuated the pro-inflammatory cytokines TNF-alpha, IL-1beta, and high-mobility group box (HMGB) 1.	Hydrogen	14-16	high mobility group box 1	Rattus norvegicus	158-190
13677801-7	2003	Quantitative MR techniques (e.g., MR volumetry, DWI, magnetization transfer MR imaging, and 1H MRS) and PET are sensitive to the structural and functional changes in the brains of patients with MCI, and hippocampal volumes on MR imaging are associated with future development of AD in these individuals.	Hydrogen	92-94	MROS	Homo sapiens	95-98
26183084-4	2015	Moreover, the SAR was robust for this series of PAMs, and both polar and hydrogen-bond donors were found to be tolerated, leading to analogs with overall attractive profiles and good ligand efficiencies.	Hydrogen	73-81	sarcosine dehydrogenase	Homo sapiens	14-17
12787894-9	2003	Met-639 participates in hydrophobic interactions mainly with GC side chains, while Asn-564 forms a hydrogen bond to the C11-OH group of the steroid.	Hydrogen	99-107	RNA polymerase III subunit K	Homo sapiens	120-123
26253656-10	2015	Furthermore, H2 could elevate anti-inflammatory cytokine IL-10 levels in LPS-stimulated HUVECs and in lung tissue from CLP mice.	Hydrogen	13-15	hyaluronan and proteoglycan link protein 1	Mus musculus	119-122
26106067-10	2015	Simulations of Y39F revealed increased conformational rearrangement of F39, which allowed formation of a new hydrogen bond between BPTI R17 and H40 of the variant.	Hydrogen	109-117	spleen trypsin inhibitor I	Bos taurus	131-135
12600201-6	2003	A sequence specific hydrogen bond, accompanied by a significantly increased roll and consequent bending in the 10S (+) adduct, has been found in our simulations for the CA*C sequence, which could account for the enhanced nucleotide excision repair as well as the syn-anti equilibrium difference we observe in this isomer and sequence.	Hydrogen	20-28	synemin	Homo sapiens	263-266
26328838-5	2015	These intrinsic potentials are employed together with existing ones for H2, H2O, and (H2O)2, to obtain full PESs for H2(H2O) and H2(H2O)2.	Hydrogen	72-74	relaxin 2	Homo sapiens	117-123
12626419-5	2003	Interestingly, the most abundant oligosaccharide was monoglucosylated Man9-GlcNAc2, which was characterized by normal-phase HPLC, mass spectrometry, Aspergillus saitoi alpha-mannosidase digestion, and 1H 600 MHz NMR spectrometry.	Hydrogen	201-203	mannosidase alpha class 1A member 1	Homo sapiens	70-74
12586353-0	2003	NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes.	Hydrogen	65-73	cathelicidin antimicrobial peptide	Mus musculus	32-36
26328838-5	2015	These intrinsic potentials are employed together with existing ones for H2, H2O, and (H2O)2, to obtain full PESs for H2(H2O) and H2(H2O)2.	Hydrogen	72-74	relaxin 2	Homo sapiens	129-135
26328838-7	2015	These PESs together with an existing one for water clusters are used in a many-body representation of the PES of hydrogen clathrate hydrates, illustrated for H2@(H2O)20.	Hydrogen	113-121	relaxin 2	Homo sapiens	158-168
12586353-1	2003	Sodium-hydrogen exchanger regulatory factor isoform-1 (NHERF-1) and NHERF-2 are two structurally related PDZ-domain-containing protein adapters that effectively transduce cyclic AMP (cAMP) signals that inhibit NHE3, the sodium-hydrogen exchanger isoform present at the apical surface of kidney and gut epithelia.	Hydrogen	7-15	cathelicidin antimicrobial peptide	Mus musculus	183-187
26289479-2	2015	Using nuclear magnetic resonance (NMR) spectroscopy, x-ray crystallography and hydrogen/deuterium exchange (HDX) mass spectrometry, here we show an allosteric mechanism through which RXR co-operates with a permissive dimer partner, peroxisome proliferator-activated receptor (PPAR)-gamma, while rendered generally unresponsive by a non-permissive dimer partner, thyroid hormone (TR) receptor.	Hydrogen	79-87	retinoid X receptor alpha	Homo sapiens	183-186
12769505-10	2003	Using an enzyme assay, we determined that caspase-3-like activity in the yolk sac was induced 1.7-fold by HS, 4.4-fold by 4CP, and 3.3-fold by ST.	Hydrogen	106-108	caspase 3	Mus musculus	42-51
26130721-4	2015	Using amine crosslinking and hydrogen-deuterium exchange coupled to mass spectrometry, we describe the architecture of the Prp19 sub-complex that contains CTNNBL1.	Hydrogen	29-37	catenin beta like 1	Homo sapiens	155-162
12492902-2	2003	In addition, the solution structure of peptide 1 that contains a phenylalanine residue (F186 in hCD81) known to be critical in the binding interaction with HCV-E2 was determined using 1D and 2D 1H NMR spectroscopy.	Hydrogen	194-196	CD81 molecule	Homo sapiens	96-101
26129708-0	2015	Spin-inversion and spin-selection in the reactions FeO(+) + H2 and Fe(+) + N2O.	Hydrogen	60-62	spindlin 1	Homo sapiens	0-4
26129708-0	2015	Spin-inversion and spin-selection in the reactions FeO(+) + H2 and Fe(+) + N2O.	Hydrogen	60-62	spindlin 1	Homo sapiens	19-23
26129708-2	2015	The reaction of electronic ground state (6)FeO(+) with H2 was found to predominantly produce electronically excited (4)Fe(+) as opposed to electronic ground state (6)Fe(+) corresponding to a spin-allowed reaction.	Hydrogen	55-57	spindlin 1	Homo sapiens	191-195
26129708-4	2015	While the overall reaction of (6)FeO(+) with H2 within the Two-State-Reactivity concept is governed by efficient sextet-quartet spin-inversion in the initial reaction complex, the observation of predominant (4)Fe(+) production in the reaction is attributed to a much less efficient quartet-sextet back-inversion in the final reaction complex.	Hydrogen	45-47	spindlin 1	Homo sapiens	128-132
25722011-4	2015	Glucocorticoid receptor number and binding affinity (Kd) in the hippocampus were measured using [(3)H2]-dexamethasone radioreceptor assay.	Hydrogen	100-102	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	0-23
12552528-4	2003	When chemically modified tips were used for STM measurements, contrast enhancements at specific regions in the STM images occurred on the basis of hydrogen bond and metal-coordination interactions.	Hydrogen	147-155	sulfotransferase family 1A member 3	Homo sapiens	44-47
12552528-4	2003	When chemically modified tips were used for STM measurements, contrast enhancements at specific regions in the STM images occurred on the basis of hydrogen bond and metal-coordination interactions.	Hydrogen	147-155	sulfotransferase family 1A member 3	Homo sapiens	111-114
12459898-7	2003	The electron-transfer rates between the mediator and GOx have been found to be accelerated by intermolecular electrostatic interactions or hydrogen bonds.	Hydrogen	139-147	hydroxyacid oxidase 1	Homo sapiens	53-56
12405534-1	2002	Photoinduced hydrogen production with Mg chlorophyll-a from spirulina as a visible light photosensitizer by use of three component system consisting of nicotineamide adenine dinucleotide phosphate, reduced form (NADPH) as an electron donor, methylviologen as electron relay reagent and colloidal platinum as hydrogen evolution catalyst was investigated.	Hydrogen	13-21	2,4-dienoyl-CoA reductase 1	Homo sapiens	212-217
12405534-1	2002	Photoinduced hydrogen production with Mg chlorophyll-a from spirulina as a visible light photosensitizer by use of three component system consisting of nicotineamide adenine dinucleotide phosphate, reduced form (NADPH) as an electron donor, methylviologen as electron relay reagent and colloidal platinum as hydrogen evolution catalyst was investigated.	Hydrogen	308-316	2,4-dienoyl-CoA reductase 1	Homo sapiens	212-217
12482234-5	2002	Amino acid substitutions that greatly reduce rBChE sensitivity to ethephon are G117H and G117K in the oxyanion hole (which may interfere with hydrogen bonding between glycine-N-H and ethephon dianion) and A328F, A328W, and A328Y (perhaps by impeding access to the active site gorge).	Hydrogen	142-150	butyrylcholinesterase	Rattus norvegicus	45-50
12602516-0	2002	Clinical significance of basal ganglia alterations at brain MRI and 1H MRS in cirrhosis and role in the pathogenesis of hepatic encephalopathy.	Hydrogen	68-70	MROS	Homo sapiens	71-74
12602516-1	2002	In hepatic encephalopathy, a progressive and diffuse impairment in brain function is associated with gradual alterations that can be detected by magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS).	Hydrogen	222-224	MROS	Homo sapiens	225-228
12602516-5	2002	The application of a test designed to evaluate patients with Parkinson"s disease (where extrapyramidal signs are typical) showed significant clinical correlations both with pallidal hyperintensity and with choline/creatine ratio at 1H MRS in BG structures.	Hydrogen	232-234	MROS	Homo sapiens	235-238
12425631-2	2002	Both are analogues for the NH...O hydrogen bonds in the active site of Ca(II)-containing phosphotransferase.	Hydrogen	34-42	carbonic anhydrase 2	Homo sapiens	71-77
12425631-3	2002	Crystallographic studies of these Ca(II) complexes revealed that the amide NHs are directed to uncoordinated O atoms of the phosphates, and the IR and 1H NMR spectra indicate that strong NH...O hydrogen bonds are formed only in the phosphate dianion state.	Hydrogen	151-153	carbonic anhydrase 2	Homo sapiens	34-40
12425631-3	2002	Crystallographic studies of these Ca(II) complexes revealed that the amide NHs are directed to uncoordinated O atoms of the phosphates, and the IR and 1H NMR spectra indicate that strong NH...O hydrogen bonds are formed only in the phosphate dianion state.	Hydrogen	194-202	carbonic anhydrase 2	Homo sapiens	34-40
12431886-0	2002	A DFT/ab initio study of hydrogen bonding and conformational preference in model cellobiose analogs using B3LYP/6-311++G**.	Hydrogen	25-33	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	108-111
12370832-0	2002	Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.	Hydrogen	56-64	MDM2 proto-oncogene	Homo sapiens	0-5
12370832-0	2002	Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.	Hydrogen	56-64	beta-secretase 2	Homo sapiens	116-121
12197713-2	2002	We analyzed the chemical shift modulation contribution of labile hydrogens in bovine pancreatic trypsin inhibitor (BPTI) to the transverse 1H spin relaxation rate, R2, of the bulk solvent.	Hydrogen	65-74	spleen trypsin inhibitor I	Bos taurus	115-119
12197713-2	2002	We analyzed the chemical shift modulation contribution of labile hydrogens in bovine pancreatic trypsin inhibitor (BPTI) to the transverse 1H spin relaxation rate, R2, of the bulk solvent.	Hydrogen	139-141	spleen trypsin inhibitor I	Bos taurus	115-119
12197713-4	2002	This analysis provided, for the first time, the hydrogen exchange rate constants for Lys and Arg side chains in a protein and pointed to an internal catalysis of the N-terminal amino protons in BPTI by a salt bridge.	Hydrogen	48-56	spleen trypsin inhibitor I	Bos taurus	194-198
27446734-0	2002	Electron-Impact Cross Sections for Dipole- and Spin-Allowed Excitations of Hydrogen, Helium, and Lithium.	Hydrogen	75-83	spindlin 1	Homo sapiens	47-51
27446734-1	2002	Electron-impact excitation cross sections are presented for the dipole- and spin allowed transitions from the ground states to the np (2)P states for hydrogen and lithium, and to the 1snp (1)P states for helium, n = 2 through 10.	Hydrogen	150-158	spindlin 1	Homo sapiens	76-80
12122471-1	2002	Ca2+ and human cardiac troponin I (cTnI) peptide binding to human cardiac troponin C (cTnC) have been investigated with the use of 2D [1H,15N] HSQC NMR spectroscopy.	Hydrogen	135-137	troponin I3, cardiac type	Homo sapiens	35-39
12238602-0	2002	1H, 15N and 13C assignments of full length human ADP ribosylation factor 1 (ARF1) using triple resonance connectivities and dipolar couplings.	Hydrogen	0-2	ADP ribosylation factor 1	Homo sapiens	49-74
12238602-0	2002	1H, 15N and 13C assignments of full length human ADP ribosylation factor 1 (ARF1) using triple resonance connectivities and dipolar couplings.	Hydrogen	0-2	ADP ribosylation factor 1	Homo sapiens	76-80
12049637-3	2002	Applying multi-dimensional high-resolution NMR techniques on unlabelled and 15N-enriched recombinant human E-FABP, the 1H and 15N resonance assignments were completed.	Hydrogen	119-121	fatty acid binding protein 5	Homo sapiens	107-113
11980488-9	2002	These results suggest that the proper organization of the hydrogen bond network within OEC for the water oxidation chemistry requires the Ca2+ ion and indicate that the role of Ca2+ is not purely structurally defined by the physical properties of the ion, such as valence and ionic radius.	Hydrogen	58-66	carbonic anhydrase 2	Homo sapiens	138-141
11980488-9	2002	These results suggest that the proper organization of the hydrogen bond network within OEC for the water oxidation chemistry requires the Ca2+ ion and indicate that the role of Ca2+ is not purely structurally defined by the physical properties of the ion, such as valence and ionic radius.	Hydrogen	58-66	carbonic anhydrase 2	Homo sapiens	177-180
11980488-10	2002	On the basis of these and other findings, we propose that Ca2+ is necessary for the formation of the hydrogen bond network that is involved in the reaction step of water oxidation.	Hydrogen	101-109	carbonic anhydrase 2	Homo sapiens	58-61
11934523-6	2002	When normalized against bovine GAPDH as an internal control, 0.5 or 1h treatment with 10 ng/mL insulin gave 39+/-4 and 64+/-2-fold increase in leptin mRNA compared with 0 h control.	Hydrogen	68-70	glyceraldehyde-3-phosphate dehydrogenase	Bos taurus	31-36
11934523-6	2002	When normalized against bovine GAPDH as an internal control, 0.5 or 1h treatment with 10 ng/mL insulin gave 39+/-4 and 64+/-2-fold increase in leptin mRNA compared with 0 h control.	Hydrogen	68-70	leptin	Bos taurus	143-149
11934523-7	2002	Leptin mRNA was increased 257+/-9 and 75+/-23-fold by 0.5 or 1h treatment with 10 ng/mL IGF-I.	Hydrogen	61-63	leptin	Bos taurus	0-6
12026973-4	2002	Hydrogen isotopic fractionation was highly reproducible for the PM1 pure cultures, with epsilon values of -33/1000 +/- 5/1000 to -37/1000 +/- 4/1000 for replicate samples.	Hydrogen	0-8	transmembrane protein 11	Homo sapiens	64-67
26233103-8	2015	Geometry optimization of stationary structures for the hydrogen abstraction step by AlkB shows some differences between QM/MM-LREC and the conventional QM/MM.	Hydrogen	55-63	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	84-88
26133569-0	2015	Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer.	Hydrogen	64-72	Nef	Human immunodeficiency virus 1	42-45
12153019-0	2002	Anaerobic biotransformation of RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) by aquifer bacteria using hydrogen as the sole electron donor.	Hydrogen	103-111	radixin	Homo sapiens	31-34
25971962-3	2015	Here, the solution structure of Pdc and its interaction with the 14-3-3 protein were investigated using small angle x-ray scattering, time-resolved fluorescence spectroscopy, and hydrogen-deuterium exchange coupled to mass spectrometry.	Hydrogen	179-187	phosducin	Homo sapiens	32-35
11792457-6	2002	Mitochondrial membrane potential as well as the protein levels of Bcl-2 and Bcl-x(L) decreased 15-60 min and 1-3 h after the exposure to NaCN (1mM, 1h), respectively.	Hydrogen	148-150	BCL2 like 1	Gallus gallus	76-81
25752909-12	2015	Notably, the pyranosyl moiety of dTDP-Qui4N is positioned into the active site by only one hydrogen bond provided by Lys 77.	Hydrogen	91-99	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	33-37
11878991-3	2002	The syn-boat-chair isomer, however, can continue to invert to the anti-boat-chair isomer until lower temperatures, and thus, the benzylic hydrogens continue to exchange for this isomer.	Hydrogen	138-147	synemin	Homo sapiens	4-7
26011121-7	2015	The atomic insight into MGMT protein by computational approach showed a significant change in the intra molecular hydrogen bond pattern, thus leading to the observed structural anomalies.	Hydrogen	114-122	O-6-methylguanine-DNA methyltransferase	Homo sapiens	24-28
11866600-3	2002	The related deprotonation of N-Boc-4-tosyloxypiperidine (6) with two molar equiv of sec-BuL-(-)-sparteine also involves preferential transfer of the pro-S hydrogen.	Hydrogen	155-163	BOC cell adhesion associated, oncogene regulated	Homo sapiens	31-34
26191363-4	2015	Meanwhile, substitution of the pyrimidine NH with an oxygen atom reversed the PLK1/BRD4 selectivity to convert BI-2536 into a BRD4-selective inhibitor, likely owing to the loss of a critical hydrogen bond in PLK1.	Hydrogen	191-199	polo like kinase 1	Homo sapiens	78-82
11897340-0	2002	Crystal packing and hydrogen bonding in platinum(II) nucleotide complexes: X-ray crystal structure of [Pt(MeSCH(2)CH(2)SMe)(5"-GMP-N7)(2)].6H(2)O.	Hydrogen	20-28	5'-nucleotidase, cytosolic II	Homo sapiens	127-130
11897346-1	2002	P. stutzeri cytochrome c(4) is a di-haem protein, composed of two globular domains each with His-Met coordinated haem, and a hydrogen bond network between the domains.	Hydrogen	125-133	cytochrome c3 family protein	Pseudomonas stutzeri	12-24
26221308-8	2015	We found hydrogen-rich solutions treatment groups showed the decreased MDA, MPO, IL-6 and TNF-alpha levels, and increased SOD, IL-10 comparing with those of non-hydrogen solutions administration groups.	Hydrogen	9-17	interleukin 10	Homo sapiens	127-132
11912930-4	2002	Investigations using solvent hydrogen isotope effects and enhancement of catalysis by exogenous proton donors show that kcat near 10(4) sec-1 contains a significant contribution from proton transfer steps.	Hydrogen	29-37	secretory blood group 1, pseudogene	Homo sapiens	136-141
25800647-4	2015	Docking study of 7a in Mnk2 suggests that the compound is stabilised in the ATP binding site through multiple hydrogen bonds and hydrophobic interaction.	Hydrogen	110-118	MAPK interacting serine/threonine kinase 2	Homo sapiens	23-27
12391577-3	2002	The [H3O] loss proceeds via loss of water to form a pyran ion, which subsequently eliminates a hydrogen atom to form the stable pyrillium cation.	Hydrogen	95-103	H3 clustered histone 15	Homo sapiens	5-8
11775746-0	2001	1H, 15N and 13C assignments of the catalytic domain of E6-associated protein (E6AP).	Hydrogen	0-2	ubiquitin protein ligase E3A	Homo sapiens	55-76
25255720-0	2015	Hydrogen-bonded His93 as a sensitive probe for identifying inhibitors of the endocannabinoid transport protein FABP7.	Hydrogen	0-8	fatty acid binding protein 7	Homo sapiens	111-116
11775746-0	2001	1H, 15N and 13C assignments of the catalytic domain of E6-associated protein (E6AP).	Hydrogen	0-2	ubiquitin protein ligase E3A	Homo sapiens	78-82
25801010-2	2015	It is found that the bare zBPNR (0H-zBPNR) or monohydrogenated zBPNR (1H-zBPNR) exhibit spin-semiconducting properties arising from the edge electronic states.	Hydrogen	70-72	spindlin 1	Homo sapiens	88-92
11602241-2	2001	Unusually large non-linear 1H and 15N nuclear magnetic resonance chemical shifts against pressure have been detected for individual amide groups of the Ras-binding domain of Ral guanine dissociation stimulator (GDS).	Hydrogen	27-29	RAS like proto-oncogene A	Homo sapiens	174-177
25813047-4	2015	It also uncovers HG-like bps with syn purines lacking HG hydrogen bonds or constricted C1"-C1" distances that are analogous to conformations that have been proposed to populate the WC-to-HG transition pathway.	Hydrogen	57-65	synemin	Homo sapiens	34-37
11580287-5	2001	Both of these enzymes along with the corresponding recombinant native CcP (recNATCcP), which was expressed in a standard medium with normal hydrogen isotope abundance, consisted of 294 amino acid polypeptide chains having the identical sequence to the yeast-isolated enzyme, without any N-terminal modifications.	Hydrogen	140-148	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	70-73
11513578-7	2001	The interactions between Rac1 and RhoGDI occur through hydrogen bonds which involve a number of residues of Rac1, namely, Tyr64(Rac), Arg66(Rac), His103(Rac), and His104(Rac), conserved within the Rho family and localized in the switch II region or in its close neighborhood.	Hydrogen	55-63	Rac family small GTPase 1	Homo sapiens	25-29
11513578-7	2001	The interactions between Rac1 and RhoGDI occur through hydrogen bonds which involve a number of residues of Rac1, namely, Tyr64(Rac), Arg66(Rac), His103(Rac), and His104(Rac), conserved within the Rho family and localized in the switch II region or in its close neighborhood.	Hydrogen	55-63	Rac family small GTPase 1	Homo sapiens	108-112
11513578-7	2001	The interactions between Rac1 and RhoGDI occur through hydrogen bonds which involve a number of residues of Rac1, namely, Tyr64(Rac), Arg66(Rac), His103(Rac), and His104(Rac), conserved within the Rho family and localized in the switch II region or in its close neighborhood.	Hydrogen	55-63	Rac family small GTPase 1	Homo sapiens	25-28
11513578-7	2001	The interactions between Rac1 and RhoGDI occur through hydrogen bonds which involve a number of residues of Rac1, namely, Tyr64(Rac), Arg66(Rac), His103(Rac), and His104(Rac), conserved within the Rho family and localized in the switch II region or in its close neighborhood.	Hydrogen	55-63	Rac family small GTPase 1	Homo sapiens	108-111
25995909-2	2015	In the crystal, an O-H O hydrogen bond between the hy-droxy groups at the C-3 and C-2 positions connects homochiral mol-ecules into a column along the b axis.	Hydrogen	25-33	complement C3	Homo sapiens	74-77
25863066-6	2015	In addition, G24-label spectra provide evidence for a partially disordered alpha-helix backbone that participates in hydrogen bonding with the surrounding water.	Hydrogen	117-125	lactamase beta	Homo sapiens	13-16
25501899-11	2015	Eliminating peroxynitrite with hydrogen-rich saline protected against hyperalgesia and attenuated DMT1(-)IRE overexpression and iron accumulation.	Hydrogen	31-39	RoBo-1	Rattus norvegicus	98-102
11473265-6	2001	Moreover, deprotection is broadly distributed throughout MDH, suggesting that it results from breaking hydrogen bonds between MDH and the cavity wall or global destabilization, as opposed to forced mechanical unfolding.	Hydrogen	103-111	malic enzyme 1	Homo sapiens	126-129
25501899-13	2015	CONCLUSIONS: Our study identifies that spinal peroxynitrite activates DMT1(-)IRE, leading to abnormal iron accumulation in remifentanil-induced postoperative hyperalgesia, while providing the rationale for the development of molecular hydrogen and "iron-targeted" therapies.	Hydrogen	235-243	RoBo-1	Rattus norvegicus	70-74
25225131-8	2015	At pH &gt;6.5, dehydration at the binding interface and several contacts between nonpolar groups of sTTR and HSPG were also coupled to binding for an optimal hydrogen-bond network.	Hydrogen	158-166	syndecan 2	Homo sapiens	109-113
11384053-12	2001	The high residual error variances, the low h2, and the inconsistency in genetic correlations that were observed particularly at the beginning of the first lactation suggest that log(e) SCC early in the first lactation may be related to a spike in SCC as result of infection and (or) onset of lactation while SCC later in lactation represents a sustained response to infection.	Hydrogen	43-45	SCC	Bos taurus	185-188
11276099-8	2001	1H-MRSI revealed metabolic differences between SCA2 and SCA6 patients.	Hydrogen	0-2	ataxin 2	Homo sapiens	47-51
11276099-8	2001	1H-MRSI revealed metabolic differences between SCA2 and SCA6 patients.	Hydrogen	0-2	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	56-60
25969814-6	2015	syn-Bromo and syn-iodo derivatives appeared to be isostructural, showing X   O (carbonyl) interactions, pi stacking, and formation of extended hydrogen bonding networks.	Hydrogen	143-151	synemin	Homo sapiens	0-3
25969814-6	2015	syn-Bromo and syn-iodo derivatives appeared to be isostructural, showing X   O (carbonyl) interactions, pi stacking, and formation of extended hydrogen bonding networks.	Hydrogen	143-151	synemin	Homo sapiens	14-17
25799058-8	2015	Asp164 within the alpha-helix and the C-terminal loop mediate a hydrogen bond network, which reinforces ubiquitin-binding of FAAP20-UBZ.	Hydrogen	64-72	FA core complex associated protein 20	Homo sapiens	125-135
25631762-5	2015	The synchrotron-based in situ X-ray diffraction (XRD), together with the corresponding temperature-programmed reduction by hydrogen (H2-TPR), indicated a structural evolution of the iron-oxide supports, correlating to their reducibility.	Hydrogen	123-131	translocated promoter region, nuclear basket protein	Homo sapiens	136-139
25750990-10	2015	Molecular Dynamics (MD) simulation study of docked complexes, PGB01-DfrA7 and E. coli TMP-sensitive-Dfr with trimethoprim (TMP) showed loss of some of the hydrogen and hydrophobic interaction between TMP and mutated residues in PGB01-DfrA7-TMP complex compared to TMP-sensitive-Dfr-TMP complex.	Hydrogen	155-163	DfrA7	Escherichia coli	68-73
25750990-10	2015	Molecular Dynamics (MD) simulation study of docked complexes, PGB01-DfrA7 and E. coli TMP-sensitive-Dfr with trimethoprim (TMP) showed loss of some of the hydrogen and hydrophobic interaction between TMP and mutated residues in PGB01-DfrA7-TMP complex compared to TMP-sensitive-Dfr-TMP complex.	Hydrogen	155-163	DfrA7	Escherichia coli	234-239
25884722-3	2015	METHODS: Bioactivity guided fractionation and isolation of bioactive compound from FVBM extract has been done to isolate and characterize the potent HMG-CoA reductase (HMGR) inhibitor with antioxidant activity by using repeated extensive column chromatography followed by spectroscopic methods, including Infrared (IR), 1H &amp; 13C nuclear magnetic resonance (NMR) and Mass spectrum analysis.	Hydrogen	320-322	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	149-166
25884722-3	2015	METHODS: Bioactivity guided fractionation and isolation of bioactive compound from FVBM extract has been done to isolate and characterize the potent HMG-CoA reductase (HMGR) inhibitor with antioxidant activity by using repeated extensive column chromatography followed by spectroscopic methods, including Infrared (IR), 1H &amp; 13C nuclear magnetic resonance (NMR) and Mass spectrum analysis.	Hydrogen	320-322	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	168-172
25716814-8	2015	Analysis of crystal structures reveals that nonsecosteroidal VDRMs bind to VDR in a position similar to 1,25 (OH) 2D3 and that hydrogen bond interactions between ligands and VDR are important for VDR transactivation.	Hydrogen	127-135	vitamin D receptor	Homo sapiens	61-64
25521423-0	2015	NMR studies of active-site properties of human carbonic anhydrase II by using (15) N-labeled 4-methylimidazole as a local probe and histidine hydrogen-bond correlations.	Hydrogen	142-150	carbonic anhydrase 2	Homo sapiens	47-68
25505081-7	2015	Residues from both monomers contributed to the HBGA binding and involved a network of direct hydrogen bonds and water-mediated interactions.	Hydrogen	93-101	hemoglobin subunit gamma 1	Homo sapiens	47-51
27490033-6	2015	The results of our analysis indicate that C1156Y mutation alters the conformation of the ALK binding pocket residues which results in a marked decrease in hydrogen bond interactions between crizotinib and ALK.	Hydrogen	155-163	ALK receptor tyrosine kinase	Homo sapiens	89-92
27490033-6	2015	The results of our analysis indicate that C1156Y mutation alters the conformation of the ALK binding pocket residues which results in a marked decrease in hydrogen bond interactions between crizotinib and ALK.	Hydrogen	155-163	ALK receptor tyrosine kinase	Homo sapiens	205-208
25490973-0	2015	Theoretical insight into hydrogen adsorption onto graphene: a first-principles B3LYP-D3 study.	Hydrogen	25-33	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	81-84
25431995-7	2015	In addition, hydrogen bond interactions between the inhibitors and the catalytic Lys78 (Mnk1), Lys113 (Mnk2) and Ser131 (Mnk1), Ser166 (Mnk2) appear to be important for the potency and stability of the bound conformations of the inhibitors.	Hydrogen	13-21	MAPK interacting serine/threonine kinase 1	Homo sapiens	88-92
25431995-7	2015	In addition, hydrogen bond interactions between the inhibitors and the catalytic Lys78 (Mnk1), Lys113 (Mnk2) and Ser131 (Mnk1), Ser166 (Mnk2) appear to be important for the potency and stability of the bound conformations of the inhibitors.	Hydrogen	13-21	MAPK interacting serine/threonine kinase 2	Homo sapiens	103-107
25431995-7	2015	In addition, hydrogen bond interactions between the inhibitors and the catalytic Lys78 (Mnk1), Lys113 (Mnk2) and Ser131 (Mnk1), Ser166 (Mnk2) appear to be important for the potency and stability of the bound conformations of the inhibitors.	Hydrogen	13-21	MAPK interacting serine/threonine kinase 1	Homo sapiens	121-125
25431995-7	2015	In addition, hydrogen bond interactions between the inhibitors and the catalytic Lys78 (Mnk1), Lys113 (Mnk2) and Ser131 (Mnk1), Ser166 (Mnk2) appear to be important for the potency and stability of the bound conformations of the inhibitors.	Hydrogen	13-21	MAPK interacting serine/threonine kinase 2	Homo sapiens	136-140
25486108-3	2015	Here we report that (100) diamond, when functionalized with hydrogen, supports a p-type spin-3/2 two-dimensional surface conductivity with a spin-orbit interaction of 9.74 +- 0.1 meV through the observation of weak antilocalization effects in magneto-conductivity measurements at low temperature.	Hydrogen	60-68	spindlin 1	Homo sapiens	88-92
25486108-3	2015	Here we report that (100) diamond, when functionalized with hydrogen, supports a p-type spin-3/2 two-dimensional surface conductivity with a spin-orbit interaction of 9.74 +- 0.1 meV through the observation of weak antilocalization effects in magneto-conductivity measurements at low temperature.	Hydrogen	60-68	spindlin 1	Homo sapiens	141-145
25624750-5	2015	Our docking study showed that ALS, MLN8054, and VX-680 preferentially bound to AURKA over AURKB via hydrogen bond formation, charge interaction, and pi-pi stacking.	Hydrogen	100-108	aurora kinase B	Homo sapiens	90-95
26422353-1	2015	OBJECTIVE: The purpose of this study was to investigate the effects of intraperitoneal hydrogen (H2) injection on the mRNA expression levels of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) as well as the serum malondialdehyde (MDA) level in a rabbit model of limb ischemia-reperfusion (I/R)-induced skeletal muscle injury.	Hydrogen	87-95	nitric oxide synthase, endothelial	Oryctolagus cuniculus	187-220
26422353-1	2015	OBJECTIVE: The purpose of this study was to investigate the effects of intraperitoneal hydrogen (H2) injection on the mRNA expression levels of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) as well as the serum malondialdehyde (MDA) level in a rabbit model of limb ischemia-reperfusion (I/R)-induced skeletal muscle injury.	Hydrogen	87-95	nitric oxide synthase, endothelial	Oryctolagus cuniculus	222-226
26422353-1	2015	OBJECTIVE: The purpose of this study was to investigate the effects of intraperitoneal hydrogen (H2) injection on the mRNA expression levels of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) as well as the serum malondialdehyde (MDA) level in a rabbit model of limb ischemia-reperfusion (I/R)-induced skeletal muscle injury.	Hydrogen	97-99	nitric oxide synthase, endothelial	Oryctolagus cuniculus	187-220
26422353-1	2015	OBJECTIVE: The purpose of this study was to investigate the effects of intraperitoneal hydrogen (H2) injection on the mRNA expression levels of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) as well as the serum malondialdehyde (MDA) level in a rabbit model of limb ischemia-reperfusion (I/R)-induced skeletal muscle injury.	Hydrogen	97-99	nitric oxide synthase, endothelial	Oryctolagus cuniculus	222-226
26422353-8	2015	Intraperitoneal injection of H2 can down-regulate iNOS mRNA expression and up-regulate eNOS mRNA expression in the I/R process, suggesting a protective effect of H2 in I/R-induced skeletal muscle injury.	Hydrogen	29-31	nitric oxide synthase, endothelial	Oryctolagus cuniculus	87-91
26422353-8	2015	Intraperitoneal injection of H2 can down-regulate iNOS mRNA expression and up-regulate eNOS mRNA expression in the I/R process, suggesting a protective effect of H2 in I/R-induced skeletal muscle injury.	Hydrogen	162-164	nitric oxide synthase, endothelial	Oryctolagus cuniculus	87-91
25997722-9	2015	The levels of p-Akt (Ser 473) and Bcl-2 were significantly increased while Bax and cleaved caspase-3 were decreased by hydrogen treatment on the model of H/R.	Hydrogen	119-127	BCL2-associated X protein	Mus musculus	75-78
11172761-8	2001	There was also a significant correlation between 1H-MRS [NAA] and the corresponding reduction in CA1 neuronal density (P&lt;0.004).	Hydrogen	49-51	carbonic anhydrase 1	Homo sapiens	97-100
11256816-0	2001	1H, 13C and 15N resonance assignments and secondary structure of the c-Myc binding domain (MBD) and the SH3 domain of the tumor suppressor Bin1.	Hydrogen	0-2	bridging integrator 1	Homo sapiens	139-143
25587872-4	2015	Our results identified the E2 binding site on GPER/GPR30, as well as other receptor cavities for accepting large volume ligands, through GPER/GPR30 pi-pi, hydrophobic, and hydrogen bond interactions.	Hydrogen	172-180	G protein-coupled estrogen receptor 1	Homo sapiens	46-50
25587872-4	2015	Our results identified the E2 binding site on GPER/GPR30, as well as other receptor cavities for accepting large volume ligands, through GPER/GPR30 pi-pi, hydrophobic, and hydrogen bond interactions.	Hydrogen	172-180	G protein-coupled estrogen receptor 1	Homo sapiens	51-56
11777394-3	2001	Hydrogen was eliminated as the condensate upon the formation of silyl ether bonds linking the PCL blocks, yielding within 24 h, silyl ether-coupled PCLs of molecular mass 7590, 29,900, and 29,500 g/mol, respectively.	Hydrogen	0-8	PHD finger protein 1	Homo sapiens	94-97
25279828-6	2015	Moreover, it was found that H2 S selectively increased the surface expression and currents of NMDA-type glutamate receptor subunit 2B (GluN2B)-containing NMDA receptors (NMDARs) in lateral amygdala of rats, whereas blockade of GluN2B-containing NMDARs in lateral amygdala eliminated the effects of H2 S to enhance amygdalar long-term potentiation and cued fear memory.	Hydrogen	28-30	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	135-141
11697047-3	2001	Using human glycosylasparaginase from human amniotic fluid, L-aspartic acid and four of its analogues, where the alpha-amino group was substituted with a chloro, bromo, methyl or hydrogen, were competitive inhibitors having Ki values between 0.6-7.7 mM.	Hydrogen	179-187	aspartylglucosaminidase	Homo sapiens	12-32
25279828-6	2015	Moreover, it was found that H2 S selectively increased the surface expression and currents of NMDA-type glutamate receptor subunit 2B (GluN2B)-containing NMDA receptors (NMDARs) in lateral amygdala of rats, whereas blockade of GluN2B-containing NMDARs in lateral amygdala eliminated the effects of H2 S to enhance amygdalar long-term potentiation and cued fear memory.	Hydrogen	28-30	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	227-233
25878401-4	2015	Results showed that hydrogen-rich saline attenuated the following: (1) serum Cr and BUN, (2) pancreatic and renal pathological injuries, (3) renal MDA, (4) renal MPO, (5) serum IL-1beta, IL-6, and renal TNF-alpha, HMGB1, and (6) tyrosine nitration, IkappaB degradation, and NF-kappaB activation in renal tissues.	Hydrogen	20-28	high mobility group box 1	Rattus norvegicus	214-219
11727705-5	2001	It is particularly true for human tropoelastin, because its sequence is rich in glycines and prolines, and these residues are frequently met in beta-turns (a beta-turn is made of four consecutive residues which are stabilized by an hydrogen bond).	Hydrogen	232-240	elastin	Homo sapiens	34-46
11052079-5	2000	Without Mg2+, the anti- (with respect to the carbonyl dipole) hydrogen is 3 to 32 times more reactive than the corresponding syn-hydrogen, whereas, when Mg2+ is present in the system, the selectivity is shifted toward the syn-preferency.	Hydrogen	62-70	synemin	Homo sapiens	125-128
11052079-5	2000	Without Mg2+, the anti- (with respect to the carbonyl dipole) hydrogen is 3 to 32 times more reactive than the corresponding syn-hydrogen, whereas, when Mg2+ is present in the system, the selectivity is shifted toward the syn-preferency.	Hydrogen	62-70	synemin	Homo sapiens	222-225
11052079-5	2000	Without Mg2+, the anti- (with respect to the carbonyl dipole) hydrogen is 3 to 32 times more reactive than the corresponding syn-hydrogen, whereas, when Mg2+ is present in the system, the selectivity is shifted toward the syn-preferency.	Hydrogen	129-137	synemin	Homo sapiens	125-128
26451138-3	2015	Here we have applied hydrogen/deuterium exchange (HDX) mass spectrometry to characterize the effects of Bexarotene on the conformational plasticity of the intact RXRalpha:PPARgamma heterodimer.	Hydrogen	21-29	retinoid X receptor alpha	Homo sapiens	162-170
11052079-5	2000	Without Mg2+, the anti- (with respect to the carbonyl dipole) hydrogen is 3 to 32 times more reactive than the corresponding syn-hydrogen, whereas, when Mg2+ is present in the system, the selectivity is shifted toward the syn-preferency.	Hydrogen	129-137	synemin	Homo sapiens	222-225
25837689-12	2015	The VolSurf model highlighted the chemical features (including large molecule size, hydrophilic regions and hydrogen-bonding groups) contributing to favored glucuronidation by UGT1A3.	Hydrogen	108-116	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	176-182
11076080-9	2000	Molecular modelling suggests the formation of four hydrogen bonds between the hydroxyl groups at positions C-2, C-3 and C-4 of alpha-D-methyl-mannoside and the bridging and ring nitrogen atoms of the triazine scaffold, with aromatic stacking of a second ligand against the carbohydrate face.	Hydrogen	51-59	complement C3	Homo sapiens	112-115
10966816-5	2000	The specificity for the CA-p2 substrate peptide is mainly hydrophobic, as most of the hydrogen bonds are made with the backbone of the peptide substrate.	Hydrogen	86-94	cyclase associated actin cytoskeleton regulatory protein 2	Homo sapiens	24-29
25327985-2	2014	SABRE is a method, which utilizes spin order transfer from para-hydrogen to the spins of a substrate in transient complexes using suitable catalysts.	Hydrogen	64-72	spindlin 1	Homo sapiens	34-38
10966644-2	2000	In this study, we used hydrogen exchange measurements to show that there is selective destabilization of one half of the beta-sandwich structure of TTR under such conditions.	Hydrogen	23-31	transthyretin	Homo sapiens	148-151
25327985-5	2014	Spin mixing at LACs allows one to polarize substrates at high fields as well; the achievable NMR enhancements are around 360 for the ortho-protons of partially deuterated pyridine used as a substrate and around 700 for H2 and substrate in the active complex with the catalyst.	Hydrogen	219-221	spindlin 1	Homo sapiens	0-4
24849281-9	2014	The DBS solvent phases tend to cluster in regions of Hansen space and are highly influenced by the hydrogen-bonding HSP, delta(h).	Hydrogen	99-107	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	116-119
10966647-7	2000	An extended hydrogen bonding network, unique to the complex of two Hah1 molecules, stabilizes the metal binding sites and suggests specific roles for several conserved residues.	Hydrogen	12-20	antioxidant 1 copper chaperone	Homo sapiens	67-71
10846172-9	2000	Thus, hydrogen bond networks consisting of the heme carboxylate, Tyr(706), and Arg(414) are crucial in stabilizing the appropriate conformation(s) of the heme active site for H4B/l-Arg binding and/or efficient electron transfer to occur.	Hydrogen	6-14	H4 clustered histone 4	Homo sapiens	175-178
25091737-4	2014	Structural analyses of the AR-LBD-BUD31 complex revealed formation of an extra hydrogen bond between the Tyr+5 residue of the peptide and the AR.	Hydrogen	79-87	BUD31 homolog	Homo sapiens	34-39
10811659-9	2000	However, these residues participate in micellar bile salt modulation of CEL enzymatic activity through intramolecular hydrogen bonding with the C-terminal domain.	Hydrogen	118-126	carboxyl ester lipase	Rattus norvegicus	72-75
25429931-6	2014	For complete basis set (CBS) predictions of hydrogen transfer reaction energies, the OMP2.5 method exhibits a substantially better performance than MP2.5, providing a mean absolute error of 1.1 kcal mol(-1), which is more than 10 times lower than that of MP2.5 (11.8 kcal mol(-1)), and comparing to MP2 (14.6 kcal mol(-1)) there is a more than 12-fold reduction in errors.	Hydrogen	44-52	microfibril associated protein 5	Homo sapiens	86-91
10889023-6	2000	PTP1B is able to bind phosphopeptides by utilizing common interactions involving the aromatic ring and phosphate moiety of phosphotyrosine itself, two conserved hydrogen bonds between the Asp48 carboxylate side chain and the main chain nitrogens of the pTyr and residue 1, and a third between the main chain nitrogen of Arg47 and the main chain carbonyl of residue -2.	Hydrogen	161-169	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	0-5
25393959-13	2014	Docking of adenosine and inosine inside A2A showed that the main difference is the formation by adenosine of an additional hydrogen bond between the NH2 of the adenine group and the residues Asn253 in H6 and Glu169 in EL2 of the A2A receptor.	Hydrogen	123-131	immunoglobulin kappa variable 2D-29	Homo sapiens	40-43
10990205-7	2000	The main degradation product of the cyclic-His peptide formed at pH 7.4 in the presence of ascorbate/Cu(II)/O2 was isolated by preparative HPLC and identified by 1H NMR and electrospray mass spectrometry.	Hydrogen	162-164	immunoglobulin kappa variable 1D-39	Homo sapiens	101-110
25393959-13	2014	Docking of adenosine and inosine inside A2A showed that the main difference is the formation by adenosine of an additional hydrogen bond between the NH2 of the adenine group and the residues Asn253 in H6 and Glu169 in EL2 of the A2A receptor.	Hydrogen	123-131	immunoglobulin kappa variable 2D-29	Homo sapiens	229-232
25241067-0	2014	Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via regulation of NR2B-containing NMDA receptor in rats.	Hydrogen	0-8	superoxide dismutase 2	Rattus norvegicus	77-82
10835282-0	2000	Molten globule structure of equine beta-lactoglobulin probed by hydrogen exchange.	Hydrogen	64-72	beta-lactoglobulin	Bos taurus	35-53
10835282-1	2000	The molten globule structure of equine beta-lactoglobulin has been inferred from the hydrogen exchange protection of the backbone amide protons.	Hydrogen	85-93	beta-lactoglobulin	Bos taurus	39-57
25241067-0	2014	Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via regulation of NR2B-containing NMDA receptor in rats.	Hydrogen	0-8	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	111-115
25151410-5	2014	The histidine forms eight hydrogen bonds with HisRS of which six engage the amino and carboxylate groups of this amino acid.	Hydrogen	26-34	histidyl-tRNA synthetase 2, mitochondrial	Homo sapiens	46-51
10841796-3	2000	NAC at high pH predominantly exists in a trans thiolate-carboxylate rotameric form, whereas protonation promotes the occurrence of intramolecular hydrogen bond-forming isomers.	Hydrogen	146-154	X-linked Kx blood group	Homo sapiens	0-3
10944005-3	2000	A 1h incubation of astrocyte primary cultures with 10 microM Pb caused a 2.5 fold increase in AP-1 DNA binding.	Hydrogen	2-4	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-98
25192004-3	2014	The solvated MeOH or EtOH molecules occupy vacant space, giving contacts with [1-4](2+), and connects to the Hal(-) ion through a hydrogen bridge via the H(1O)O(1S) H atom forming, by means of the Hal(-)   HOR (Hal = Cl, Br) contact, the halide-alcohol cluster.	Hydrogen	130-138	histidine ammonia-lyase	Homo sapiens	109-112
10748083-2	2000	Here we present evidence suggesting that a conserved RING-H2 structure within ROC1 is critical for its ubiquitin ligation function.	Hydrogen	58-60	ring-box 1	Homo sapiens	78-82
10909873-0	2000	Sequence-specific 1H, 15N, and 13C assignment of the N-terminal domain of the human oncoprotein MDM2 that binds to p53.	Hydrogen	18-20	MDM2 proto-oncogene	Homo sapiens	84-100
25192004-3	2014	The solvated MeOH or EtOH molecules occupy vacant space, giving contacts with [1-4](2+), and connects to the Hal(-) ion through a hydrogen bridge via the H(1O)O(1S) H atom forming, by means of the Hal(-)   HOR (Hal = Cl, Br) contact, the halide-alcohol cluster.	Hydrogen	130-138	histidine ammonia-lyase	Homo sapiens	197-200
25192004-3	2014	The solvated MeOH or EtOH molecules occupy vacant space, giving contacts with [1-4](2+), and connects to the Hal(-) ion through a hydrogen bridge via the H(1O)O(1S) H atom forming, by means of the Hal(-)   HOR (Hal = Cl, Br) contact, the halide-alcohol cluster.	Hydrogen	130-138	histidine ammonia-lyase	Homo sapiens	197-200
26278453-2	2014	The azido stretch mode of HN3 is found to be a promising infrared probe for studying the structure and local hydrogen-bond environment of confined and interfacial water in reverse micelle due to its narrow spectral bandwidth and large transition dipole moment.	Hydrogen	109-117	MT-RNR2 like 3 (pseudogene)	Homo sapiens	26-29
26278453-5	2014	The influence of local hydrogen bond network in the first and higher solvation shells on the vibrational dynamics of HN3 is further discussed.	Hydrogen	23-31	MT-RNR2 like 3 (pseudogene)	Homo sapiens	117-120
10774023-3	2000	Free enthalpies, calculated by using electronic energy at the higher theory level and with inclusion of solvent effects, indicates that syn, exo TSs, where the olefinic OH group hydrogen bonds the peroxy oxygens of the peroxy acid, outweigh syn, endo TSs, where the peroxy acid carbonyl oxygen is involved in hydrogen bonding.	Hydrogen	178-186	synemin	Homo sapiens	136-139
10774023-3	2000	Free enthalpies, calculated by using electronic energy at the higher theory level and with inclusion of solvent effects, indicates that syn, exo TSs, where the olefinic OH group hydrogen bonds the peroxy oxygens of the peroxy acid, outweigh syn, endo TSs, where the peroxy acid carbonyl oxygen is involved in hydrogen bonding.	Hydrogen	178-186	synemin	Homo sapiens	241-244
26278456-1	2014	A method is proposed to transfer spin order from para-hydrogen, that is, the H2 molecule in its singlet state, to spin-1/2 heteronuclei of a substrate molecule.	Hydrogen	54-62	spindlin 1	Homo sapiens	114-122
10774023-3	2000	Free enthalpies, calculated by using electronic energy at the higher theory level and with inclusion of solvent effects, indicates that syn, exo TSs, where the olefinic OH group hydrogen bonds the peroxy oxygens of the peroxy acid, outweigh syn, endo TSs, where the peroxy acid carbonyl oxygen is involved in hydrogen bonding.	Hydrogen	309-317	synemin	Homo sapiens	136-139
26278456-1	2014	A method is proposed to transfer spin order from para-hydrogen, that is, the H2 molecule in its singlet state, to spin-1/2 heteronuclei of a substrate molecule.	Hydrogen	77-79	spindlin 1	Homo sapiens	114-122
10733977-7	2000	Notably, direct readout is shown not to be capable of discriminating between AA and AT steps, as the strength of the hydrogen bonds between TBP and the DNA are the same for both sequences.	Hydrogen	117-125	TATA-box binding protein	Homo sapiens	140-143
23754699-0	2014	1H, 13C and 15N backbone and side-chain resonance assignments of the N-terminal ubiquitin-binding domains of the human deubiquitinase Usp28.	Hydrogen	0-2	ubiquitin specific peptidase 28	Homo sapiens	134-139
10805136-0	2000	Assignments of 1H, 13C, and 15N resonances of intramolecular dimer antifreeze protein RD3.	Hydrogen	15-17	RD3 regulator of GUCY2D	Homo sapiens	86-89
23754700-0	2014	1H, 13C and 15N backbone and side-chain resonance assignments of the N-terminal ubiquitin-binding domains of USP25.	Hydrogen	0-2	ubiquitin specific peptidase 25	Homo sapiens	109-114
23838815-0	2014	1H, 13C and 15N backbone and side-chain chemical shift assignments of the free and bound forms of the human PTPN11 second SH2 domain.	Hydrogen	0-2	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	108-114
10653700-12	2000	It participates in the formation of a dimeric structure between symmetry-related BPTI molecules, in which electrostatic and hydrogen bonding interactions resulting from the mutated Lys15Arg substitution are of central importance.	Hydrogen	124-132	spleen trypsin inhibitor I	Bos taurus	81-85
23925854-0	2014	1H, 15N, and 13C chemical shift assignments of murine calcium-binding protein 4.	Hydrogen	0-2	calcium binding protein 4	Mus musculus	54-79
10653800-4	2000	The interaction resulted in dehydration of the sulfate, changes in the intermolecular hydrogen bonding interactions of the sugar and other oxygens, decreased intermolecular hydrogen bonding of the amide C==O of GalC and dehydration of the amide region of one or both of the lipids in the mixture, and disordering of the hydrocarbon chains of both lipids.	Hydrogen	173-181	galactosylceramidase	Homo sapiens	211-215
25257535-4	2014	The results show that 11b-OH on ring-C and 4b-OH on ring-D could form two hydrogen bonds with Glu449 and Phe382 of Syk, respectively.	Hydrogen	74-82	spleen associated tyrosine kinase	Homo sapiens	115-118
10652248-3	2000	We now show that HS, 4-CP, and staurosporine (ST) induce the release of cytochrome c from mitochondria with kinetics suggesting a causal relationship with the activation of caspase-3 and caspase-2.	Hydrogen	17-19	caspase 3	Mus musculus	173-182
25125283-5	2014	The 7 a,b(syn,anti)/Et3 SiH/B(C6 F5 )3 co-catalytic systems were highly active in various olefin hydrogenations (60 bar H2 , 140  C), with maximum TOFs of 5250 h(-1) (7 a(syn,anti)) and 8200 h(-1) (7 b(syn,anti)) for 1-hexene hydrogenation.	Hydrogen	120-122	synemin	Homo sapiens	10-13
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) &gt; tert-butyl hydroperoxide (tert-BuOOH, 607 cps) &gt; hydrogen peroxide (H(2)O(2), 455 cps) &gt; cumene hydroperoxide (cumene-OOH, 261 cps).	Hydrogen	236-240	linoleate 9S-lipoxygenase-4	Glycine max	18-30
25125283-5	2014	The 7 a,b(syn,anti)/Et3 SiH/B(C6 F5 )3 co-catalytic systems were highly active in various olefin hydrogenations (60 bar H2 , 140  C), with maximum TOFs of 5250 h(-1) (7 a(syn,anti)) and 8200 h(-1) (7 b(syn,anti)) for 1-hexene hydrogenation.	Hydrogen	120-122	synemin	Homo sapiens	171-174
25125283-5	2014	The 7 a,b(syn,anti)/Et3 SiH/B(C6 F5 )3 co-catalytic systems were highly active in various olefin hydrogenations (60 bar H2 , 140  C), with maximum TOFs of 5250 h(-1) (7 a(syn,anti)) and 8200 h(-1) (7 b(syn,anti)) for 1-hexene hydrogenation.	Hydrogen	120-122	synemin	Homo sapiens	171-174
25012815-4	2014	All intra-molecular hydrogen bonds of anti-syn cellobiose are replaced by inter-molecular hydrogen bonds formed with the anions, whereas the anti-anti conformer retains an intramolecular hydrogen bond.	Hydrogen	20-28	synemin	Homo sapiens	43-46
10541551-2	1999	The OCA-B peptide binds in the major groove near the center of the octamer site, and its polypeptide backbone forms a pair of hydrogen bonds with the adenine base at position 5 of the octamer DNA.	Hydrogen	126-134	POU class 2 homeobox associating factor 1	Homo sapiens	4-9
24880703-5	2014	Class B CpG ODN induced upregulation of TLR21 and IFN-gamma mRNA expression levels at 1h post-stimulation depending on concentration of ODN used but only in HG cells isolated from young birds.	Hydrogen	86-88	interferon gamma	Gallus gallus	50-59
10508399-8	1999	We conclude that the conserved residue Val61 is located at one of the key positions, the "electrostatic potential" around the heme-exposed area and the hydrophobicity of the heme pocket are determinant factors modulating the redox potential of cytochrome b(5), and the hydrogen bond network around the exposed heme edge is also an important factor affecting the heme stability.	Hydrogen	269-277	cytochrome b	Bos taurus	244-256
10530928-14	1999	Both enantiomers of 1 could form a hydrogen bond between their 5-methoxy substituent and Thr200 in TM5, which may account for their full serotonin 5-HT1A receptor agonist properties.	Hydrogen	35-43	tropomyosin 3	Homo sapiens	99-102
24974344-4	2014	These fragment scaffolds were subsequently evaluated for interaction with the VDR ligand binding domain using hydrogen-deuterium exchange (HDX) mass spectrometry.	Hydrogen	110-118	vitamin D receptor	Homo sapiens	78-81
24858299-9	2014	Moreover, the corresponding thermodynamical data showed that at pH&gt;6.5, van der Waals and hydrogen bonds due to aromatic amino acids as tyrosine or phenylalanine present in the N-terminal (NT) part governed the Abeta/HSPG association.	Hydrogen	93-101	syndecan 2	Homo sapiens	220-224
10423253-13	1999	These results indicate that the 4"-hydroxyl-N(1) hydrogen bond plays a major role in the stabilization of the anionic semiquinone and anionic hydroquinone oxidation states of ETF and that this hydrogen bond may provide a pathway for electron transfer between the ETF flavin and the flavin of ETF-QO.	Hydrogen	49-57	electron transfer flavoprotein dehydrogenase	Homo sapiens	292-298
10423253-13	1999	These results indicate that the 4"-hydroxyl-N(1) hydrogen bond plays a major role in the stabilization of the anionic semiquinone and anionic hydroquinone oxidation states of ETF and that this hydrogen bond may provide a pathway for electron transfer between the ETF flavin and the flavin of ETF-QO.	Hydrogen	193-201	electron transfer flavoprotein dehydrogenase	Homo sapiens	292-298
24890947-0	2014	Hydrogen gas protects against serum and glucose deprivation-induced myocardial injury in H9c2 cells through activation of the NF-E2-related factor 2/heme oxygenase 1 signaling pathway.	Hydrogen	0-8	heme oxygenase 1	Rattus norvegicus	149-165
25062251-2	2014	For further insight into the interaction of PEX3 and PEX19, we used hydrogen exchange mass spectrometry to monitor conformational changes during complex formation between PEX3 and PEX19 in vitro.	Hydrogen	68-76	peroxisomal biogenesis factor 3	Homo sapiens	171-175
10393343-7	1999	Loss of or altered hydrogen bond interactions involving the water molecules bridging the sialic acid to the protein was found to be the major cause for the observed drop in CT-B affinity in the smaller derivatives, while in the bulkier derivatives, hydrophobic interactions with the protein were found to partly compensate for these losses.	Hydrogen	19-27	phosphate cytidylyltransferase 1B, choline	Homo sapiens	173-177
25062251-4	2014	However, we could detect three changes, one each in the N-and C-terminus along with a small stretch in the middle of PEX19 (F64-L74) which became shielded from hydrogen exchange when interacting with PEX3.	Hydrogen	160-168	peroxisomal biogenesis factor 3	Homo sapiens	200-204
10387071-10	1999	A simplified view shows this cluster with a single negative charge (on AspL213 with a hydrogen bond to SerL233) in the ground state.	Hydrogen	86-94	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	71-75
25062251-5	2014	PEX3 became more protected from hydrogen exchange in the binding groove for PEX19 with only small changes elsewhere.	Hydrogen	32-40	peroxisomal biogenesis factor 3	Homo sapiens	0-4
24751343-3	2014	FTIR analysis indicated that the existence of hydrogen bonds between SA and the PCL matrix improved drug compatibility.	Hydrogen	46-54	PHD finger protein 1	Homo sapiens	80-83
10365965-0	1999	Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.	Hydrogen	20-28	aldo-keto reductase family 1 member A1	Homo sapiens	58-79
10365965-6	1999	Using a thermophilic alcohol dehydrogenase (ADH), we find that hydrogen tunnelling makes a significant contribution at 65 degrees C; this is analogous to previous findings with mesophilic ADH at 25 degrees C. Contrary to predictions for tunnelling through a rigid barrier, the tunnelling with the thermophilic ADH decreases at and below room temperature.	Hydrogen	31-39	aldo-keto reductase family 1 member A1	Homo sapiens	44-47
24820024-0	2014	Plastidial Expression of Type II NAD(P)H Dehydrogenase Increases the Reducing State of Plastoquinones and Hydrogen Photoproduction Rate by the Indirect Pathway in Chlamydomonas reinhardtii1.	Hydrogen	106-114	uncharacterized protein	Chlamydomonas reinhardtii	41-54
10336646-0	1999	1H-NMR structural studies of a cystine-linked peptide containing residues 71-93 of transthyretin and effects of a Ser84 substitution implicated in familial amyloidotic polyneuropathy.	Hydrogen	0-2	transthyretin	Homo sapiens	83-96
24820024-5	2014	With the aim of identifying the limiting step of hydrogen production, we succeeded in overexpressing the plastidial type II NAD(P)H dehydrogenase (NDA2).	Hydrogen	49-57	uncharacterized protein	Chlamydomonas reinhardtii	147-151
24865376-5	2014	Moreover, the hydrogen bond and energy decomposition analyses indicate that apart from residue 181, point mutations have influence on the interactions of substrate with several residues in the active site of PTP1B.	Hydrogen	14-22	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	208-213
10395492-4	1999	Oconovine (8) was converted to 8-hydroxy-O-methyloconovine (12) to determine the effect of oxygenation at C-8 on the proton chemical shift of the C-7 hydrogens in a study to support the C-8 ether linkage of alkaloids 3 and 4.	Hydrogen	150-159	complement C7	Homo sapiens	146-149
24918063-9	2014	In particular, we proposed a pharmacophore model featuring two amino groups in the central part of the model and two lateral aromatic chains, which respectively establish electrostatic interactions with the acidic loop (Asp 108 and Glu 109) and a hydrogen bond with Ser 139, which is one of the key residues for Cdc34 activity.	Hydrogen	247-255	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	312-317
10388841-1	1999	Backbone mimicry by the formation of closed-loop C7, C10 and C13 (mimics of gamma-, beta- and alpha-turns) conformations through side chain-main chain hydrogen bonds by polar groups is a frequent observation in protein structures.	Hydrogen	151-159	homeobox C13	Homo sapiens	61-64
24643241-4	2014	Importantly, we have characterized a hydrogen bond between the beta-phosphate of UDP and the backbone amide group from the Thr7 of the sugar acceptor (EA2 peptide) that promotes catalysis and that we propose could be a general catalytic strategy used in peptide O-glycosylation by retaining glycosyltransferases.	Hydrogen	37-45	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	151-154
10336444-4	1999	Tertiary structure modifications, induced by addition of Ca2+, were evaluated by deuterium/hydrogen exchange kinetic measurements for the reconstituted exchanger.	Hydrogen	91-99	carbonic anhydrase 2	Homo sapiens	57-60
24700593-5	2014	The results show that the conserved residues Phe819, Phe871, Trp875, Trp929, Trp899, and Arg845 located at the concave face of zNOD2-LRR confer MDP recognition by hydrophobic and hydrogen bond (H-bond) interactions.	Hydrogen	179-187	nucleotide-binding oligomerization domain containing 2	Danio rerio	127-132
10320325-2	1999	The three-dimensional structure of HCC-2 has been determined by 1H nuclear magnetic resonance (NMR) spectroscopy and restrained molecular dynamics calculations on the basis of 871 experimental restraints.	Hydrogen	64-66	C-C motif chemokine ligand 15	Homo sapiens	35-40
24608976-0	2014	A novel tescalcin-sodium/hydrogen exchange axis underlying sorafenib resistance in FLT3-ITD+ AML.	Hydrogen	25-33	tescalcin	Homo sapiens	8-17
24601644-0	2014	Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.	Hydrogen	55-63	MDM2 proto-oncogene	Homo sapiens	24-28
10092645-8	1999	In addition, LFM-A13 is capable of favorable hydrogen bonding interactions with BTK via Asp539 and Arg525 residues.	Hydrogen	45-53	Bruton tyrosine kinase	Homo sapiens	80-83
10353199-0	1999	1H, 15N, and 13C resonance assignments for the N-terminal 20 kDa domain of the DNA single-strand break repair protein XRCC1.	Hydrogen	0-2	X-ray repair cross complementing 1	Homo sapiens	118-123
24625033-6	2014	By comparing the oxysterol profile formed from 7-DHC and those formed from 8-DHC and 5,8(14)-dienol, products formed from abstraction of the hydrogen atoms at C-9 and C-14 (H-9 or H-14 mechanism) were clearly differentiated.	Hydrogen	141-149	complement C9	Homo sapiens	159-162
23250791-0	2014	1H, 13C, and 15N chemical shift assignments of neuronal calcium sensor protein, hippocalcin.	Hydrogen	0-2	hippocalcin	Homo sapiens	80-91
10066743-10	1999	These results are consistent with at least two hydrogen bonds stabilizing the bound oxygen molecule, one from tyrosine B10 and the other from the distal glutamine.	Hydrogen	47-55	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	119-122
23315337-0	2014	1H, 13C, and 15N chemical shift assignments of the phosphotyrosine binding domain 2 (PTB2) of human FE65.	Hydrogen	0-2	polypyrimidine tract binding protein 1	Homo sapiens	51-83
10939849-2	1999	The BDE"s of benzyl hydrogens (C-2 position in catechins) were found to be quite low.	Hydrogen	20-29	homeobox D13	Homo sapiens	4-7
24631364-2	2014	The combined MD simulations and QM/MM-PBSA calculations reveal that the most important structural parameters affecting the CYP2A6-inhibitor binding affinity are two crucial internuclear distances, that is, the distance between the heme iron atom of CYP2A6 and the coordinating atom of the inhibitor, and the hydrogen-bonding distance between the N297 side chain of CYP2A6 and the pyridine nitrogen of the inhibitor.	Hydrogen	308-316	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	123-129
10189269-3	1998	The pH-rate expression was k(pH) = kH1 f1(aH+) + kH2 f2(aH+) + ks + kOH(aOH-), where kH1 and kH2 are the catalytic constants (M(-1) h(-1)) for hydrogen ion activity (aH+), kOH is the catalytic constant for hydroxyl ion activity (aOH-), and ks is the first-order rate constant (h(-1)) for spontaneous degradation.	Hydrogen	143-151	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	49-52
24631364-2	2014	The combined MD simulations and QM/MM-PBSA calculations reveal that the most important structural parameters affecting the CYP2A6-inhibitor binding affinity are two crucial internuclear distances, that is, the distance between the heme iron atom of CYP2A6 and the coordinating atom of the inhibitor, and the hydrogen-bonding distance between the N297 side chain of CYP2A6 and the pyridine nitrogen of the inhibitor.	Hydrogen	308-316	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	249-255
10189269-3	1998	The pH-rate expression was k(pH) = kH1 f1(aH+) + kH2 f2(aH+) + ks + kOH(aOH-), where kH1 and kH2 are the catalytic constants (M(-1) h(-1)) for hydrogen ion activity (aH+), kOH is the catalytic constant for hydroxyl ion activity (aOH-), and ks is the first-order rate constant (h(-1)) for spontaneous degradation.	Hydrogen	143-151	potassium voltage-gated channel modifier subfamily F member 1	Homo sapiens	85-88
10189269-3	1998	The pH-rate expression was k(pH) = kH1 f1(aH+) + kH2 f2(aH+) + ks + kOH(aOH-), where kH1 and kH2 are the catalytic constants (M(-1) h(-1)) for hydrogen ion activity (aH+), kOH is the catalytic constant for hydroxyl ion activity (aOH-), and ks is the first-order rate constant (h(-1)) for spontaneous degradation.	Hydrogen	143-151	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	93-96
24631364-2	2014	The combined MD simulations and QM/MM-PBSA calculations reveal that the most important structural parameters affecting the CYP2A6-inhibitor binding affinity are two crucial internuclear distances, that is, the distance between the heme iron atom of CYP2A6 and the coordinating atom of the inhibitor, and the hydrogen-bonding distance between the N297 side chain of CYP2A6 and the pyridine nitrogen of the inhibitor.	Hydrogen	308-316	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	249-255
24165164-7	2014	Furthermore, ability to inhibit both MAO-A and MAO-B can be potentialized by the formation of hydrogen bonds between these compounds and FAD and/or the residues in the active site.	Hydrogen	94-102	monoamine oxidase B	Homo sapiens	47-52
9810691-5	1998	We also found that a conformation in which the phenyl groups of the N-methylbenzamide and 3,4-dichlorophenyl moieties are close to each other through a cis-amide bond, may be favorable for showing high affinity for the NK1 receptor and that a hydrogen bond-accepting group in the spiro-substituted piperidine moiety may be crucial for exhibiting high affinity for the NK2 receptor.	Hydrogen	243-251	tachykinin receptor 2	Homo sapiens	368-380
24554644-4	2014	The results showed that introduction of the intramolecular hydrogen bonds played a crucial role in promoting the stability of the (TTF( +))2 dimer and thus the noncovalent macrocyclization of the two backbones in both uni- and bimolecular manners.	Hydrogen	59-67	transcription termination factor 2	Homo sapiens	131-140
9818053-8	1998	The x-ray intensity distribution indicated that the unit structure, which is similar to a TTR monomer, is composed of a pair of beta-sheets consisting of four hydrogen-bonded beta-chains per sheet, with the beta-chains oriented approximately normal to the fiber axis.	Hydrogen	159-167	transthyretin	Homo sapiens	90-93
24418908-4	2014	It was established that the A* A(syn) DNA mismatch is stabilized by the N6H   N6 (6.35) and N1H   N7 (6.17) hydrogen (H) bonds, whereas the A A*(syn) base mispair (Cs) by the N6H   N6 (8.82) and N7H   N1 (9.78) H-bonds and the C8H   HC2 HH-bond (0.30 kcal mol(-1)).	Hydrogen	108-116	synemin	Homo sapiens	33-36
9699465-2	1998	The minimal structural modifications of the conformationally flexible Gly10 residue, as substitutions for L-Ala, D-Ala, or Aib (replacing of hydrogen atoms by methyl groups), were applied to obtain octa- and heptapeptide analogues of alpha-MSH(4-11) and alpha-MSH(5-11), which were cyclized by lactam bridges between the side chains in positions 5 and 11.	Hydrogen	141-149	ANIB1	Homo sapiens	123-126
24418908-4	2014	It was established that the A* A(syn) DNA mismatch is stabilized by the N6H   N6 (6.35) and N1H   N7 (6.17) hydrogen (H) bonds, whereas the A A*(syn) base mispair (Cs) by the N6H   N6 (8.82) and N7H   N1 (9.78) H-bonds and the C8H   HC2 HH-bond (0.30 kcal mol(-1)).	Hydrogen	108-116	synemin	Homo sapiens	145-148
9785913-3	1998	The aim of our study was to investigate oro-cecal transit time (OCTT) using the H2-breath test (H2-BT) in moderate and heavy drinkers.	Hydrogen	80-82	H2B clustered histone 20, pseudogene	Homo sapiens	96-101
24429940-2	2014	Two types of structural isomers exhibiting different interaction motifs are identified for the TRA(+)-N2 dimer, namely the TRA(+)-N2(H) global minimum, in which N2 forms a linear hydrogen bond (H-bond) to the indolic NH group, and the less stable TRA(+)-N2(pi) local minima, in which N2 binds to the aromatic pi electron system of the indolic pyrrole ring.	Hydrogen	179-187	T cell receptor alpha locus	Homo sapiens	95-98
24429940-2	2014	Two types of structural isomers exhibiting different interaction motifs are identified for the TRA(+)-N2 dimer, namely the TRA(+)-N2(H) global minimum, in which N2 forms a linear hydrogen bond (H-bond) to the indolic NH group, and the less stable TRA(+)-N2(pi) local minima, in which N2 binds to the aromatic pi electron system of the indolic pyrrole ring.	Hydrogen	179-187	T cell receptor alpha locus	Homo sapiens	123-126
24429940-2	2014	Two types of structural isomers exhibiting different interaction motifs are identified for the TRA(+)-N2 dimer, namely the TRA(+)-N2(H) global minimum, in which N2 forms a linear hydrogen bond (H-bond) to the indolic NH group, and the less stable TRA(+)-N2(pi) local minima, in which N2 binds to the aromatic pi electron system of the indolic pyrrole ring.	Hydrogen	179-187	T cell receptor alpha locus	Homo sapiens	123-126
9677398-8	1998	We therefore propose that the hydroxyl group of Tyr-60 participates in a hydrogen bond that is important for the initial complex formation with IGF-I and the stabilization of this complex.	Hydrogen	73-81	IGFI	Bos taurus	144-149
24443247-2	2014	We observed that the 1,5-HAT regioselectivity can be switched between the two potentially abstractable syn-1,3-diaxial hydrogens at H6 and H8.	Hydrogen	119-128	synapsin I	Homo sapiens	103-108
24475903-1	2014	SABRE is a nuclear spin hyperpolarization technique based on the reversible association of a substrate molecule and para-hydrogen (p-H2) to a metal complex.	Hydrogen	121-129	polyhomeotic homolog 2	Homo sapiens	131-135
9653114-5	1998	The binding between the Sec7 domain and a soluble, truncated version of human Arf-1 was investigated by examining 1H-15N and 1H-13C chemical shift changes between the native protein and the Sec7/Arf-1 complex.	Hydrogen	114-116	ADP ribosylation factor 1	Homo sapiens	78-83
9653114-5	1998	The binding between the Sec7 domain and a soluble, truncated version of human Arf-1 was investigated by examining 1H-15N and 1H-13C chemical shift changes between the native protein and the Sec7/Arf-1 complex.	Hydrogen	125-127	ADP ribosylation factor 1	Homo sapiens	78-83
24757500-7	2014	Binding simulation with LSD1 indicated that the aromatic rings of the compounds and the amino group of the cyclopropylamine were important for the interaction with LSD1, and that the stereochemistry of the 1,2-disubstituted cyclopropane ring affected the position of the aromatic rings and the hydrogen bond formation of the amino group in the LSD1 catalytic site.	Hydrogen	294-302	lysine demethylase 1A	Homo sapiens	24-28
9642277-10	1998	These results, together with the number of signals observed in the two-dimensional 1H-15N heteronuclear single quantum coherence spectrum of uniformly 15N-labeled protein, indicate that hSTAT4(1-124) forms a stable, symmetric homodimer in solution.	Hydrogen	83-85	signal transducer and activator of transcription 4	Homo sapiens	186-192
24432762-4	2014	PTI nanosheets show significantly enhanced visible-light driven photocatalytic activity toward hydrogen evolution compared to their bulk counterpart, which highlights the crucial role of morphology and surface area on the photocatalytic performance of carbon nitride materials.	Hydrogen	95-103	serpin family B member 6	Homo sapiens	0-3
9616115-3	1998	This indicates that fractionation of HD/H2 relative to that of HDO/H2O is not kinetically controlled by the rates of formation and destruction of H2 and HD but is thermodynamically controlled by the isotope exchange HD + H2O left and right arrow HDO + H2.	Hydrogen	40-42	relaxin 2	Homo sapiens	146-155
24359447-3	2014	In this work, we measured the ionic hydrogen bond strengths of three enzymatically relevant model systems in the gas phase using anion photoelectron spectroscopy; we calibrated these against the hydrogen bond strength of HF2(-), measured using the same technique, and we compared our results with other gas-phase experimental data.	Hydrogen	195-203	complement factor H	Homo sapiens	221-224
11670387-5	1998	Theoretical reaction energies for formation of the (HAl-NH)(4) cluster from the (H(2)Al-NH(2))(2) ring are consistent with intermolecular loss of hydrogen, or the necessity of surface catalysis.	Hydrogen	146-154	histidine ammonia-lyase	Homo sapiens	52-55
24305678-4	2014	Using both density-functional theory in the generalized-gradient approximation and a hybrid-functional approach, the present study reports on the types of isolated hydrogen configuration that can be stabilized at the core of the Sigma5(310) tilt grain boundary, an interface whose atomistic structure has been determined in good detail by Z-contrast transmission electron microscopy.	Hydrogen	164-172	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	229-235
24253042-4	2014	Contrarily, the RFTS-deleted Dnmt1 and Dnmt1 mutants that destroyed the hydrogen bonds between the RFTS and catalytic domain showed significant DNA methylation activity even toward 12-bp hemi-methylated DNA.	Hydrogen	72-80	DNA methyltransferase 1	Homo sapiens	29-34
24253042-4	2014	Contrarily, the RFTS-deleted Dnmt1 and Dnmt1 mutants that destroyed the hydrogen bonds between the RFTS and catalytic domain showed significant DNA methylation activity even toward 12-bp hemi-methylated DNA.	Hydrogen	72-80	DNA methyltransferase 1	Homo sapiens	39-44
24253042-5	2014	The DNA methylation activity of the RFTS-deleted Dnmt1 toward 12-bp hemi-methylated DNA was strongly inhibited on the addition of RFTS, but to a lesser extent by Dnmt1 harboring the mutations that impair the hydrogen bond formation.	Hydrogen	208-216	DNA methyltransferase 1	Homo sapiens	49-54
24253042-5	2014	The DNA methylation activity of the RFTS-deleted Dnmt1 toward 12-bp hemi-methylated DNA was strongly inhibited on the addition of RFTS, but to a lesser extent by Dnmt1 harboring the mutations that impair the hydrogen bond formation.	Hydrogen	208-216	DNA methyltransferase 1	Homo sapiens	162-167
24416504-0	2014	Do Spin State and Spin Density Affect Hydrogen Atom Transfer Reactivity?	Hydrogen	38-46	spindlin 1	Homo sapiens	3-7
24416504-0	2014	Do Spin State and Spin Density Affect Hydrogen Atom Transfer Reactivity?	Hydrogen	38-46	spindlin 1	Homo sapiens	18-22
25346190-6	2014	The results were further supported by molecular docking studies, which explain the hydrogen bond interactions and binding mode of the ligands with Plk1.	Hydrogen	83-91	polo like kinase 1	Homo sapiens	147-151
24910013-9	2014	The conserved residues forming hydrogen interaction of NRBP with DENV1-4 serotypes were found to be GLN 305, SER 363 and GLN 379.	Hydrogen	31-39	nuclear receptor binding protein 1	Homo sapiens	55-59
23867098-4	2014	In this article, the conversion of waste biomass to fuel using hot and high-pressure water is reviewed, and the following examples are presented: the production of large amounts of hydrogen from waste biomass, the production of cheap bioethanol from non-food raw materials, and the production of composite powder fuel from refractory waste biomass in the rubble from the Great East Japan Earthquake.	Hydrogen	181-189	alcohol dehydrogenase iron containing 1	Homo sapiens	63-66
24327548-7	2013	This may be due to the cumulative effect of the direct hydrogen bonding between N1 and O1" and C-H   O interactions of the aglycon chain, revealing the uniqueness of the GlcNAc as the linkage sugar.	Hydrogen	55-63	immunoglobulin kappa variable 2D-40	Homo sapiens	80-90
24376700-8	2013	RESULTS: Hydrogen-rich saline pretreatment attenuated CS-induced mucus accumulation in the bronchiolar lumen, goblet cell hyperplasia, muc5ac over-expression and abnormal cell apoptosis in the airway epithelium as well as malondialdehyde increase in the BALF.	Hydrogen	9-17	mucin 5AC, oligomeric mucus/gel-forming	Rattus norvegicus	135-141
24231334-7	2013	Their binding constants range from 1.91 x 10(4)M(-1) to 12.96 x 10(4)M(-1) at 296 K. BP-8 interacts with HSA mainly through hydrogen bonding interactions and van der Waals interactions, while hydrophobic interactions and electrostatic interactions are dominant for interactions between BP-1, BP-2, BP-3 and HSA.	Hydrogen	124-132	BP8	Homo sapiens	85-89
24329083-0	2013	Spin-polarized hydrogen adsorbed on the surface of superfluid 4He.	Hydrogen	15-23	spindlin 1	Homo sapiens	0-4
24329083-1	2013	The experimental realization of a thin layer of spin-polarized hydrogen H  adsorbed on top of the surface of superfluid (4)He provides one of the best examples of a stable, nearly two-dimensional (2D) quantum Bose gas.	Hydrogen	63-71	spindlin 1	Homo sapiens	48-52
24035828-2	2013	Here, we assessed the role of the MMP-2 KO in BBB injury, HT and other brain injuries after 1h of ischemia and 23 h of reperfusion.	Hydrogen	92-94	matrix metallopeptidase 2	Mus musculus	34-39
24379064-5	2013	In tuberculosis sputum culture, the serum concentrations of IL-10 and ESR in TB positive group were 0.045+-0.013 mg/L and 62.50+-8.69 mm/1h, significantly higher than that of TB negative group (p &lt; 0.05); whereas, the concentrations of serum PCT and CRP in TB positive and negative groups had no significant difference (p &gt; 0.05).	Hydrogen	137-139	interleukin 10	Homo sapiens	60-65
24017972-6	2013	Upregulation of Nrf2 by sulforaphane treatment prior to transient MCAo (1h) was associated with increased HO-1 expression in perivascular astrocytes in peri-infarct regions and cerebral endothelium in the infarct core.	Hydrogen	72-74	heme oxygenase 1	Rattus norvegicus	106-110
24193214-5	2013	The analysis of interactions among RDX and acetone molecules reveal that the system nonbond interactions are primary strong van der Waals and electrostatic interactions containing pi-hole interactions, the weak hydrogen bond interactions are also existent.	Hydrogen	211-219	radixin	Homo sapiens	35-38
24132574-9	2013	At the end of the experiment, H2 excretion and the portal H2 concentration were significantly greater in the FOS group than in the control group.	Hydrogen	30-32	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-112
24132574-9	2013	At the end of the experiment, H2 excretion and the portal H2 concentration were significantly greater in the FOS group than in the control group.	Hydrogen	58-60	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-112
24132574-10	2013	In the FOS group, the arterial H2 concentration was no more than 1.5% of the portal H2 concentration (P = 0.03).	Hydrogen	31-33	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	7-10
24166980-1	2013	H2 , O2 to H2 O2 : The direct synthesis of hydrogen peroxide from hydrogen and oxygen in water has been made possible by using an iridium(III) complex, [Ir(III) (Cp*)(4-(1H-pyrazol-1-yl-kappaN(2) )benzoic acid-kappaC(3) )(H2 O)]2 SO4 , and flavin mononucleotide.	Hydrogen	43-51	relaxin 2	Homo sapiens	0-16
31986641-1	2013	Selective hydrogenation of phenol to cyclohexanone over a catalyst of polyaniline-functionalized carbon-nanofiber-supported palladium (Pd-PANI/CNF) with sodium formate as the hydrogen source has been studied.	Hydrogen	10-18	NPHS1 adhesion molecule, nephrin	Homo sapiens	143-146
24056936-9	2013	These structures also reveal a water-mediated hydrogen bond between two conserved tyrosines, which appears to stabilize the active state of the beta2AR and related GPCRs.	Hydrogen	46-54	adrenoceptor beta 2	Homo sapiens	144-151
9531490-2	1998	We now report fluorescence studies showing that the vesicle-inserted ShB peptide is in a monomeric form and, therefore, the observed beta-structure must be intramolecularly hydrogen-bonded to produce a beta-hairpin conformation.	Hydrogen	173-181	SH2 domain containing adaptor protein B	Homo sapiens	69-72
23350603-3	2013	CDO(-/-) mice had elevated urinary excretion of thiosulfate, high tissue and serum cystathionine and lanthionine levels, and evidence of inhibition and destabilization of cytochrome c oxidase, which is consistent with excess production of H2S/HS(-).	Hydrogen	243-245	cysteine dioxygenase 1, cytosolic	Mus musculus	0-3
9538015-0	1998	Characterization of hydrogen bonding in the complex of adenosine deaminase with a transition state analogue: a Raman spectroscopic study.	Hydrogen	20-28	adenosine deaminase	Homo sapiens	55-74
9538015-5	1998	This hydrogen bond, apparently between the N1-H of the inhibitor and the Odelta1 of Glu217 in ADA, causes a substantial N1-H bending frequency increase of about 50-100 cm-1 compared to its solution value, and this results in an estimated enthalpy of the hydrogen bond of 4-10 kcal/mol.	Hydrogen	5-13	adenosine deaminase	Homo sapiens	94-97
23350603-6	2013	INNOVATION: The CDO(-/-) mouse model provides new insights into tissue-specific cysteine metabolism, particularly the role of pancreas in metabolism of excess cysteine by CBS-catalyzed reactions, and will be a useful model for studying the effects of excess endogenous production of H2S/HS(-).	Hydrogen	287-289	cysteine dioxygenase 1, cytosolic	Mus musculus	16-19
9538015-5	1998	This hydrogen bond, apparently between the N1-H of the inhibitor and the Odelta1 of Glu217 in ADA, causes a substantial N1-H bending frequency increase of about 50-100 cm-1 compared to its solution value, and this results in an estimated enthalpy of the hydrogen bond of 4-10 kcal/mol.	Hydrogen	254-262	adenosine deaminase	Homo sapiens	94-97
23350603-7	2013	CONCLUSION: The CDO(-/-) mouse clearly demonstrates that H2S/HS(-) production in tissues can exceed the capacity of the animal to oxidize sulfide to sulfate and demonstrates that pancreas and lung are more susceptible to toxicity from endogenous H2S/HS(-)production than are liver and kidney.	Hydrogen	61-63	cysteine dioxygenase 1, cytosolic	Mus musculus	16-19
23350603-7	2013	CONCLUSION: The CDO(-/-) mouse clearly demonstrates that H2S/HS(-) production in tissues can exceed the capacity of the animal to oxidize sulfide to sulfate and demonstrates that pancreas and lung are more susceptible to toxicity from endogenous H2S/HS(-)production than are liver and kidney.	Hydrogen	250-252	cysteine dioxygenase 1, cytosolic	Mus musculus	16-19
23972473-2	2013	In this report, we determine the crystal structure of the FGFR3 kinase domain harboring this pathogenic mutation and show that the mutation introduces a network of intramolecular hydrogen bonds to stabilize the active-state conformation.	Hydrogen	179-187	fibroblast growth factor receptor 3	Homo sapiens	58-63
9566391-0	1998	Quantitative proton-decoupled 31P MRS and 1H MRS in the evaluation of Huntington"s and Parkinson"s diseases.	Hydrogen	42-44	MROS	Homo sapiens	45-48
29711264-2	1998	The metal cations in [Pd2 Cl2 L]1.5 I5 (I3 )2 are linked into infinite chains by pairwise hydrogen bonding; the resulting cationic polymers run through channels formed by the extended polyiodide network.	Hydrogen	90-98	endogenous retrovirus group W member 5	Homo sapiens	26-29
24124590-0	2013	Residues in human arsenic (+3 oxidation state) methyltransferase forming potential hydrogen bond network around S-adenosylmethionine.	Hydrogen	83-91	arsenite methyltransferase	Homo sapiens	18-64
24124590-1	2013	Residues Tyr59, Gly78, Ser79, Met103, Gln107, Ile136 and Glu137 in human arsenic (+3 oxidation state) methyltransferase (hAS3MT) were deduced to form a potential hydrogen bond network around S-adenosylmethionine (SAM) from the sequence alignment between Cyanidioschyzon merolae arsenite S-adenosylmethyltransferase (CmArsM) and hAS3MT.	Hydrogen	162-170	arsenite methyltransferase	Homo sapiens	73-119
24124590-1	2013	Residues Tyr59, Gly78, Ser79, Met103, Gln107, Ile136 and Glu137 in human arsenic (+3 oxidation state) methyltransferase (hAS3MT) were deduced to form a potential hydrogen bond network around S-adenosylmethionine (SAM) from the sequence alignment between Cyanidioschyzon merolae arsenite S-adenosylmethyltransferase (CmArsM) and hAS3MT.	Hydrogen	162-170	arsenite methyltransferase	Homo sapiens	121-127
22688683-0	2013	1H, 15N and 13C backbone resonance assignments of the Kelch domain of mouse Keap1.	Hydrogen	0-2	kelch-like ECH-associated protein 1	Mus musculus	76-81
9456299-4	1998	From the mass spectrometry and 1H-NMR data, it is concluded that D-2 and D-3 are formed from beclomethasone and beclomethasone 21-monopropionate, respectively, with the loss of hydrogen chloride and the formation of a 9,11-epoxide.	Hydrogen	31-33	immunoglobulin heavy diversity 2-15	Homo sapiens	65-76
9449318-4	1998	The 3(10) hydrogen bonds stabilizing amide NH"s of residues C-terminal to P2 and P14 were previously proposed to explain their high amide exchange stabilities.	Hydrogen	10-18	ribonuclease P/MRP subunit p14	Homo sapiens	74-84
22696136-0	2013	1H, 13C and 15N chemical shift assignments of Ninjurin1 Extracellular N-terminal Domain.	Hydrogen	0-2	ninjurin 1	Homo sapiens	46-55
22744789-0	2013	1H, 13C and 15N chemical shift assignments of unliganded Bcl-xL and its complex with a photoresponsive Bak-derived peptide.	Hydrogen	0-2	BCL2 antagonist/killer 1	Homo sapiens	103-106
9438017-15	1998	By contrast, 1H NMR and IR spectra of bromo ester 21 are indicative of syn-conformation of adenine.	Hydrogen	13-15	synemin	Homo sapiens	71-74
22886485-0	2013	1H, 13C and 15N resonance assignment for the human K-Ras at physiological pH.	Hydrogen	0-2	KRAS proto-oncogene, GTPase	Homo sapiens	51-56
9392303-5	1997	RESULTS: The addition of a 3-day oral gavage of 0.05 mg/kg/day FTY720 to a single portal vein injection of 10 microg alpha(1h)l58-80-RT1.Aa protein induced permanent acceptance of WF heart allografts in 16 of 26 ACI recipients (&gt;100 days); the alpha(1h)l58-80-RT1.Aa protein alone only modestly prolonged WF heart survival (13.8+/-0.8 days).	Hydrogen	123-125	RT1 class I, locus A	Rattus norvegicus	133-139
22903788-0	2013	Backbone and side-chain resonance assignments (1H, 15N and 13C) of the ubiquitin homology domain of mouse BAG-1.	Hydrogen	47-49	BCL2-associated athanogene 1	Mus musculus	106-111
9392303-5	1997	RESULTS: The addition of a 3-day oral gavage of 0.05 mg/kg/day FTY720 to a single portal vein injection of 10 microg alpha(1h)l58-80-RT1.Aa protein induced permanent acceptance of WF heart allografts in 16 of 26 ACI recipients (&gt;100 days); the alpha(1h)l58-80-RT1.Aa protein alone only modestly prolonged WF heart survival (13.8+/-0.8 days).	Hydrogen	253-255	RT1 class I, locus A	Rattus norvegicus	133-139
23996527-0	2013	1H, 15N, and 13C resonance assignments and secondary structure of the SWIRM domain of human BAF155, a chromatin remodeling complex component.	Hydrogen	0-2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	Homo sapiens	92-98
9371755-3	1997	In the present work, catalytic efficiency and the extent of hydrogen tunneling have been correlated for the alcohol dehydrogenase-catalyzed hydride transfer among a group of site-directed mutants at position 203.	Hydrogen	60-68	aldo-keto reductase family 1 member A1	Homo sapiens	108-129
9394675-8	1997	CONCLUSION: Broadened 1H spectra observed after c-erbB-2 or c-Ha-ras transfection suggest changes of plasma membrane viscosity, which may be related to the oncogene expression.	Hydrogen	22-24	Harvey rat sarcoma virus oncogene	Mus musculus	60-68
23960019-0	2013	Intramolecular OH   FC hydrogen bonding in fluorinated carbohydrates: CHF is a better hydrogen bond acceptor than CF2.	Hydrogen	23-31	ATPase H+ transporting accessory protein 1	Homo sapiens	114-117
9363779-1	1997	The solution structure of the major form of the reduced soluble fragment of rat microsomal cytochrome b5 has been solved through 1H-NMR spectroscopy.	Hydrogen	129-131	cytochrome b5 type A	Rattus norvegicus	91-104
23844594-3	2013	The recent discovery of Thr4 phosphorylation in the CTD calls into question whether such a modification can interfere with Ssu72 binding via the elimination of a conserved intramolecular hydrogen bond in the CTD that is potentially essential for recognition.	Hydrogen	187-195	Ssu72 CTD phosphatase	Drosophila melanogaster	123-128
9254595-4	1997	The results were consistent with homology models of the Grb2-SH2-Shc hexapeptide complex which identified several possible hydrogen bonds between Grb2-SH2 and the phosphotyrosine and conserved asparagine(+2) side chains of the Shc hexapeptide.	Hydrogen	123-131	SHC adaptor protein 1	Homo sapiens	65-68
23844594-6	2013	To our surprise, even though the intramolecular hydrogen bond is eliminated due to the phosphorylation of Thr4, the CTD adopts an almost identical conformation to be recognized by Ssu72 with Ser5 phosphorylated alone or both Thr4/Ser5 phosphorylated.	Hydrogen	48-56	Ssu72 CTD phosphatase	Drosophila melanogaster	180-185
9313858-1	1997	The MAO-B catalyzed alpha-carbon oxidation of amines has been proposed to proceed via either a single electron transfer (SET) or hydrogen atom transfer (HAT) pathway.	Hydrogen	129-137	monoamine oxidase B	Homo sapiens	4-9
23844594-6	2013	To our surprise, even though the intramolecular hydrogen bond is eliminated due to the phosphorylation of Thr4, the CTD adopts an almost identical conformation to be recognized by Ssu72 with Ser5 phosphorylated alone or both Thr4/Ser5 phosphorylated.	Hydrogen	48-56	Jonah 99Ciii	Drosophila melanogaster	191-195
23844594-6	2013	To our surprise, even though the intramolecular hydrogen bond is eliminated due to the phosphorylation of Thr4, the CTD adopts an almost identical conformation to be recognized by Ssu72 with Ser5 phosphorylated alone or both Thr4/Ser5 phosphorylated.	Hydrogen	48-56	Jonah 99Ciii	Drosophila melanogaster	230-234
24011181-2	2013	In this work, deoxygenation of technical grade methyl oleate to diesel fuel aliphatic hydrocarbons (C15 - C18) is evaluated with several parameters including temperature, hydrogen pressure and reaction time in a stirred batch reactor over Pd/SBA-15 catalysts.	Hydrogen	171-179	placenta associated 8	Homo sapiens	100-103
9235932-1	1997	The hydroxyl group of Tyr-78 of yeast guanylate kinase (GK) is hydrogen-bonded to the phosphate of the bound GMP as revealed by x-ray crystallography.	Hydrogen	63-71	guanylate kinase	Saccharomyces cerevisiae S288C	38-54
9235932-1	1997	The hydroxyl group of Tyr-78 of yeast guanylate kinase (GK) is hydrogen-bonded to the phosphate of the bound GMP as revealed by x-ray crystallography.	Hydrogen	63-71	guanylate kinase	Saccharomyces cerevisiae S288C	56-58
24011181-6	2013	Results show that H2 pressures greatly determine the total ester conversion and selectivity to C15 - C18 aliphatic hydrocarbons.	Hydrogen	18-20	placenta associated 8	Homo sapiens	95-98
9218433-6	1997	The CTE element of hERR2 is unstructured and highly flexible, exhibiting nearly random coil chemical shifts, extreme sensitivity of the backbone amide protons to solvent presaturation, and reduced heteronuclear (1H-15N) nuclear Overhauser effect values.	Hydrogen	212-214	estrogen related receptor beta	Homo sapiens	19-24
31986728-1	2013	The trideuteriomethylation of BH vertices in CB11 H12 - and its derivatives with CD3 OTf (OTf=triflate, trifluoromethanesulfonate) yields a mixture of B CD3 and B CHD2 substitution products, thus demonstrating the intermediacy of a species with a long enough lifetime for hydrogen scrambling between the boron vertex and the methyl substituent.	Hydrogen	50-53	chromodomain helicase DNA binding protein 2	Homo sapiens	163-167
11670003-1	1997	Detailed studies of the structure, conductivitity, magnetoresistance, optical spectra, and magnetic properties (susceptibility, EPR) for the new molecular metal tetrabenzporphyrin iodide (H(2)(tbp)I) and the electrical, spectral, and magnetic properties of Ni(tbp)I are reported.	Hydrogen	188-192	TATA-box binding protein	Homo sapiens	193-196
11670003-1	1997	Detailed studies of the structure, conductivitity, magnetoresistance, optical spectra, and magnetic properties (susceptibility, EPR) for the new molecular metal tetrabenzporphyrin iodide (H(2)(tbp)I) and the electrical, spectral, and magnetic properties of Ni(tbp)I are reported.	Hydrogen	188-192	TATA-box binding protein	Homo sapiens	260-263
11670003-2	1997	Paramagnetic transition-ion impurities were carefully excluded during the synthesis of H(2)(tbp)I and Ni(tbp)I, and both materials show much higher, metal-like conductivites than previously seen for less-pure Ni(tbp)I.	Hydrogen	87-91	TATA-box binding protein	Homo sapiens	92-95
11670003-3	1997	Comparison of the specular reflectance data for Ni(tbp)I and H(2)(tbp)I allows a distinction between purely ring pi-transitions and metal-involved charge-transfer transitions, and the spectra fix the energy levels of the pi orbitals involved in conduction.	Hydrogen	61-65	TATA-box binding protein	Homo sapiens	66-69
11670003-6	1997	EPR g-values for H(2)(tbp)I and Ni(tbp)I are close to that for the free electron and are nearly temperature-independent.	Hydrogen	17-21	TATA-box binding protein	Homo sapiens	22-25
11670003-6	1997	EPR g-values for H(2)(tbp)I and Ni(tbp)I are close to that for the free electron and are nearly temperature-independent.	Hydrogen	17-21	TATA-box binding protein	Homo sapiens	35-38
23702564-0	2013	1H NMR-based metabolomics studies of urine reveal differences between type 1 diabetic patients with high and low HbAc1 values.	Hydrogen	0-2	adenylate cyclase 8	Homo sapiens	113-118
23895055-9	2013	Molecular docking simulation indicated that tylophorine could form hydrogen bonds and aromatic interactions within the ATP-binding region of the VEGFR2 kinase unit.	Hydrogen	67-75	kinase insert domain receptor	Homo sapiens	145-151
9168025-4	1997	These peptide bond reversals could be accommodated without greatly perturbing the adjacent helical structure, and intramolecular hydrogen bonding was generally maintained in bent states through the formation of new (non-alpha or 3[10]) hydrogen bonds with good geometries: G11 NH-V9 CO (inverse gamma turn), Aib13 NH-Aib8 CO (pi-helix) and, rarely, L12 NH- Q7 NH (pi-helix).	Hydrogen	129-137	serine/threonine kinase 19	Homo sapiens	273-276
9255944-1	1997	The 1H NMR solution structure of the rat thyroid transcription factor 1 homeodomain (TTF-1 HD) showed that the molecule folds like classical homeodomains.	Hydrogen	4-6	transcription termination factor 1	Rattus norvegicus	85-90
23583779-1	2013	We studied hydrogen/deuterium-exchange reactions of peptide amide protons of GroES using two different techniques: (1) two-dimensional (1)H-(15)N transverse-optimized NMR spectroscopy and (2) the dimethylsulfoxide-quenched hydrogen-exchange method combined with conventional (1)H-(15)N heteronuclear single quantum coherence spectroscopy.	Hydrogen	11-19	chaperonin GroES	Escherichia coli	77-82
23743663-0	2013	Spin state modulation of iron spin crossover complexes via hydrogen-bonding self-assembly.	Hydrogen	59-67	spindlin 1	Homo sapiens	0-4
9194185-4	1997	Extensive chemical shift assignments are reported for backbone and side chain 1H, 13C, and 15N resonances of the HIV-1 Nef deletion mutants NEF delta 2-39, NEF delta 2-39, delta 159-173, and of NEF delta 2-39, delta 159-173 in complex with the SH3 domain of the Hck tyrosine protein kinase.	Hydrogen	78-80	Nef	Human immunodeficiency virus 1	119-122
9154928-1	1997	The binding of human alpha1-proteinase inhibitor to rat trypsin was shown by NMR spectroscopy to raise the pKa" of His57 in the active site but not to disrupt the hydrogen bond between His57 and Asp102.	Hydrogen	163-171	serpin family A member 1	Rattus norvegicus	21-48
23743663-0	2013	Spin state modulation of iron spin crossover complexes via hydrogen-bonding self-assembly.	Hydrogen	59-67	spindlin 1	Homo sapiens	30-34
23743663-1	2013	Iron complexes derived from 6-diaminotriazyl-2,2"-bipyridines display spin crossover behaviour, and hydrogen bonding-controlled self-assembly with a suitable barbiturate partner can modulate the crossover from mixed low and high spin to high spin.	Hydrogen	100-108	spindlin 1	Homo sapiens	229-233
9076974-8	1997	Preliminary comparative analysis of the highly purified alligator parvalbumin isoform (in the Ca2-loaded state) by two-dimensional 1H-NMR (2D 1H TOCSY and 2D 1H NOESY) indicates that there is considerable similarity in structure between the alligator protein and a homologous protein obtained from the silver hake (a saltwater fish species).	Hydrogen	131-133	parvalbumin alpha	Alligator mississippiensis	66-77
23743663-1	2013	Iron complexes derived from 6-diaminotriazyl-2,2"-bipyridines display spin crossover behaviour, and hydrogen bonding-controlled self-assembly with a suitable barbiturate partner can modulate the crossover from mixed low and high spin to high spin.	Hydrogen	100-108	spindlin 1	Homo sapiens	229-233
9076974-8	1997	Preliminary comparative analysis of the highly purified alligator parvalbumin isoform (in the Ca2-loaded state) by two-dimensional 1H-NMR (2D 1H TOCSY and 2D 1H NOESY) indicates that there is considerable similarity in structure between the alligator protein and a homologous protein obtained from the silver hake (a saltwater fish species).	Hydrogen	142-144	parvalbumin alpha	Alligator mississippiensis	66-77
9076974-8	1997	Preliminary comparative analysis of the highly purified alligator parvalbumin isoform (in the Ca2-loaded state) by two-dimensional 1H-NMR (2D 1H TOCSY and 2D 1H NOESY) indicates that there is considerable similarity in structure between the alligator protein and a homologous protein obtained from the silver hake (a saltwater fish species).	Hydrogen	142-144	parvalbumin alpha	Alligator mississippiensis	66-77
23743663-2	2013	This system is the first to use solution-phase self-assembly of complementary hydrogen-bonding organic species to modulate spin state.	Hydrogen	78-86	spindlin 1	Homo sapiens	123-127
23777370-8	2013	These results together with the work on Q210H mutant nicely explain that the C-terminal AR7 has a (207)TPLQ(210) variant and are in support of the notion that a string of TPLH/variant, which may arguably act like a zip lock to the elongated AR proteins via intra-/inter-repeat hydrogen-bonding, is important in maintaining the tertiary fold.	Hydrogen	277-285	thyroid hormone receptor alpha	Homo sapiens	88-91
9047330-0	1997	Ligand binding alters the backbone mobility of intestinal fatty acid-binding protein as monitored by 15N NMR relaxation and 1H exchange.	Hydrogen	124-126	fatty acid binding protein 2	Rattus norvegicus	47-84
23777370-8	2013	These results together with the work on Q210H mutant nicely explain that the C-terminal AR7 has a (207)TPLQ(210) variant and are in support of the notion that a string of TPLH/variant, which may arguably act like a zip lock to the elongated AR proteins via intra-/inter-repeat hydrogen-bonding, is important in maintaining the tertiary fold.	Hydrogen	277-285	death associated protein kinase 3	Homo sapiens	215-218
9037009-4	1997	We have also analyzed the structure of the GroEL-bound protein using hydrogen-deuterium exchange and NMR spectroscopy.	Hydrogen	69-77	heat shock protein family D (Hsp60) member 1	Homo sapiens	43-48
23831025-6	2013	Upon binding to SCL, LMO2 induces new hydrogen bonds in SCL:E47, thereby strengthening heterodimer formation.	Hydrogen	38-46	LIM domain only 2	Homo sapiens	21-25
8999873-9	1997	The preference of the enzyme for donor substrates with D-threo configuration at the C-3 and C-4 positions and for alpha-hydroxylated acceptor substrates can be understood from the pattern of hydrogen bonds between enzyme and substrate.	Hydrogen	191-199	complement C3	Homo sapiens	84-87
23685812-2	2013	Herein we provide a systematic theoretical investigation of this issue, based on a density functional theory method applied to a spin labeled DNA model system, focusing on the dependence of the EPR properties of the spin label on the pi stacking and hydrogen bonding that occur upon incorporating the spin label into the selected base pair inside DNA.	Hydrogen	250-258	spindlin 1	Homo sapiens	129-133
9074802-5	1997	TPO-dependent product formation, characterized by on-line LC-APCI/MS and 1H-NMR, involved oxidative elimination to form the corresponding benzoquinone with subsequent dehydrogenation at the aliphatic 4-(dimethylamino) group.	Hydrogen	73-75	thyroid peroxidase	Homo sapiens	0-3
9081541-0	1997	1H and 15N NMR resonance assignments and secondary structure of titin type I domains.	Hydrogen	0-2	bent	Drosophila melanogaster	64-69
23685812-2	2013	Herein we provide a systematic theoretical investigation of this issue, based on a density functional theory method applied to a spin labeled DNA model system, focusing on the dependence of the EPR properties of the spin label on the pi stacking and hydrogen bonding that occur upon incorporating the spin label into the selected base pair inside DNA.	Hydrogen	250-258	spindlin 1	Homo sapiens	216-220
8969229-9	1996	Vps8p contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2+ binding motif.	Hydrogen	70-72	CORVET complex membrane-binding subunit VPS8	Saccharomyces cerevisiae S288C	0-5
23685812-2	2013	Herein we provide a systematic theoretical investigation of this issue, based on a density functional theory method applied to a spin labeled DNA model system, focusing on the dependence of the EPR properties of the spin label on the pi stacking and hydrogen bonding that occur upon incorporating the spin label into the selected base pair inside DNA.	Hydrogen	250-258	spindlin 1	Homo sapiens	216-220
23869809-6	2013	A hydroxyl group at C-3 enhances trichothecene toxicity, while this activity decreases gradually when C-3 is substituted with either hydrogen or an acetoxy group.	Hydrogen	133-141	complement C3	Homo sapiens	102-105
23688053-3	2013	The hydrogen ion (H(+)) or hydronium (H3O(+)) solvation mechanism is not only a fundamental principle of acid/base chemistry in ionic liquids but also key to understanding the charge- and proton-transport properties of the PIL solutions.	Hydrogen	4-12	H3 clustered histone 15	Homo sapiens	38-41
23688053-3	2013	The hydrogen ion (H(+)) or hydronium (H3O(+)) solvation mechanism is not only a fundamental principle of acid/base chemistry in ionic liquids but also key to understanding the charge- and proton-transport properties of the PIL solutions.	Hydrogen	4-12	serpin family A member 2 (gene/pseudogene)	Homo sapiens	223-226
8956025-3	1996	We found a significant heritability for DHEAS (h2 = 0.39, p &lt; 0.001).	Hydrogen	47-49	sulfotransferase family 2A member 1	Homo sapiens	40-45
23720317-0	2013	Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in beta-cells.	Hydrogen	7-15	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	Mus musculus	26-30
11667744-5	1996	Both the cis and trans bicyclic ethers ring close on that pi-surface of the intermediate oxonium ion syn to the angular hydrogen.	Hydrogen	120-128	synemin	Homo sapiens	101-104
23720317-1	2013	NHA2 is a sodium/hydrogen exchanger with unknown physiological function.	Hydrogen	17-25	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	Mus musculus	0-4
8898894-0	1996	Analysis of the solution structure of the homeodomain of rat thyroid transcription factor 1 by 1H-NMR spectroscopy and restrained molecular mechanics.	Hydrogen	95-97	transcription termination factor 1	Rattus norvegicus	61-91
8898894-1	1996	The solution structure of the rat thyroid transcription factor 1 (TTF-1) homeodomain has been elucidated by 1H-NMR and restrained modeling.	Hydrogen	108-110	transcription termination factor 1	Rattus norvegicus	34-64
8898894-1	1996	The solution structure of the rat thyroid transcription factor 1 (TTF-1) homeodomain has been elucidated by 1H-NMR and restrained modeling.	Hydrogen	108-110	transcription termination factor 1	Rattus norvegicus	66-71
26583858-10	2013	Although the principal relations between the EDD and CST for hydrogen bonding (HB) and stacking interactions are similar, the real-space consequences are rather different.	Hydrogen	61-69	cystatin 12, pseudogene	Homo sapiens	53-56
8916426-4	1996	Unimolecular loss of hydrogen atom from C-2- and C-3-protonated pyrrole cations is preceded by proton migration in the ring.	Hydrogen	21-29	complement C3	Homo sapiens	49-52
23585235-3	2013	HD production from H2 and D2 over Pd is investigated using pulsed molecular beams, and the temperature dependence and reaction orders are obtained for the rate of HD production under various reaction conditions designed to modulate the amount of subsurface hydrogen present.	Hydrogen	257-265	relaxin 2	Homo sapiens	19-28
8873995-13	1996	In the minor groove the cytosine carbonyl oxygen atoms of the GpC and CpG steps are cross-bridged by water molecules that are not themselves hydrogen bonded but are enclosed by the water rings in the mouth of the minor groove.	Hydrogen	141-149	glycophorin C (Gerbich blood group)	Homo sapiens	62-65
8874005-4	1996	When challenged by the anionic phospholipid vesicles, the inactivating ShB peptide 1) binds to the vesicle surface with a relatively high affinity, 2) readily adopts a strongly hydrogen-bonded beta-structure, likely an intramolecular beta "hairpin," and 3) becomes inserted into the hydrophobic bilayer by its folded N-terminal portion, leaving its positively charged C-terminal end exposed to the extravesicular aqueous medium.	Hydrogen	177-185	SH2 domain containing adaptor protein B	Homo sapiens	71-74
23411268-0	2013	Characterization of oils and fats by 1H NMR and GC/MS fingerprinting: classification, prediction and detection of adulteration.	Hydrogen	37-39	chromosome 10 open reading frame 90	Homo sapiens	29-33
8870990-1	1996	The monoamine oxidase B (MAO-B) catalyzed oxidation of amines has been proposed to proceed via a polar pathway, an initial single-electron transfer pathway and an initial hydrogen atom transfer pathway.	Hydrogen	171-179	monoamine oxidase B	Homo sapiens	4-23
8870990-1	1996	The monoamine oxidase B (MAO-B) catalyzed oxidation of amines has been proposed to proceed via a polar pathway, an initial single-electron transfer pathway and an initial hydrogen atom transfer pathway.	Hydrogen	171-179	monoamine oxidase B	Homo sapiens	25-30
23131022-1	2013	AIM: H2 S, a newly discovered signaling gasotransmitter, has been found involved in the pathogenesis of portal hypertension through the H2 S/CSE system.	Hydrogen	5-7	cystathionine gamma-lyase	Homo sapiens	141-144
23131022-1	2013	AIM: H2 S, a newly discovered signaling gasotransmitter, has been found involved in the pathogenesis of portal hypertension through the H2 S/CSE system.	Hydrogen	136-138	cystathionine gamma-lyase	Homo sapiens	141-144
8718855-15	1996	Preliminary electrostatic calculations provide support for the concept that the transition state in the rate-limiting step of the citrate synthase catalyzed reaction may be an "enolized" version of acetyl-CoA that is neither neutral nor fully negatively charged and that a possible role for the catalytically essential His274 is to stabilize this by charge delocalization mediated by a hydrogen bond.	Hydrogen	386-394	citrate synthase	Sus scrofa	130-146
23553709-5	2013	Hydrogen exchange mass spectrometry (HX MS) was used as a conformational analysis method to profile experimentally the extent of hMGL-nanodisc interaction and its impact upon hMGL structure.	Hydrogen	0-8	monoglyceride lipase	Homo sapiens	129-133
23553709-5	2013	Hydrogen exchange mass spectrometry (HX MS) was used as a conformational analysis method to profile experimentally the extent of hMGL-nanodisc interaction and its impact upon hMGL structure.	Hydrogen	0-8	monoglyceride lipase	Homo sapiens	175-179
8710850-0	1996	NMR evidence for the participation of a low-barrier hydrogen bond in the mechanism of delta 5-3-ketosteroid isomerase.	Hydrogen	52-60	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	86-117
23642148-0	2013	Ab initio QM/MM calculations show an intersystem crossing in the hydrogen abstraction step in dealkylation catalyzed by AlkB.	Hydrogen	65-73	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	120-124
8760501-3	1996	GroEL and SecB catalyse the hydrogen-deuterium exchange of amide proteins of barnase that require global unfolding for exchange to occur, indicating that both chaperones bind to a fully unfolded state of barnase.	Hydrogen	28-36	heat shock protein family D (Hsp60) member 1	Homo sapiens	0-5
8663070-9	1996	EGF and amphiregulin, both with hydrogen bond donor functionalities at their hinge, displayed markedly decreased in potency by comparison with TGFalpha.	Hydrogen	32-40	amphiregulin	Homo sapiens	8-20
24900728-1	2013	2alpha-Heteroarylethyl-1alpha,25-dihydroxyvitamin D3 analogues, which were designed to form a hydrogen bond between Arg274 of human vitamin D receptor (hVDR) and a nitrogen atom of the heteroaromatic ring at the 2alpha-position, were synthesized.	Hydrogen	94-102	vitamin D receptor	Homo sapiens	132-150
24900728-1	2013	2alpha-Heteroarylethyl-1alpha,25-dihydroxyvitamin D3 analogues, which were designed to form a hydrogen bond between Arg274 of human vitamin D receptor (hVDR) and a nitrogen atom of the heteroaromatic ring at the 2alpha-position, were synthesized.	Hydrogen	94-102	vitamin D receptor	Homo sapiens	152-156
24900728-3	2013	X-ray cocrystallographic analysis of the hVDR-ligand complex confirms that the new hydrogen bond formation stabilized the complex.	Hydrogen	83-91	vitamin D receptor	Homo sapiens	41-45
23560542-5	2013	However, when this hydrogen bond is eliminated, which better mimics the DNA environment, a small (&lt;5 kJ mol(-1)) anti/syn energy difference is predicted.	Hydrogen	19-27	synemin	Homo sapiens	121-124
23586743-2	2013	The reaction of cyc-N3 with hydrogen is shown to proceed through a barrierless path that dissociates to N2 + NH((1)Delta) without reaching the HN3 global minimum.	Hydrogen	28-36	MT-RNR2 like 3 (pseudogene)	Homo sapiens	143-146
23132142-4	2013	AHP1 binds AHK5(RD) via a prominent hydrogen bond docking ridge and a hydrophobic patch.	Hydrogen	36-44	histidine kinase 5	Arabidopsis thaliana	11-15
23450779-2	2013	There is significant variation in PIL hydrogen bond interactions ranging from short and linear to long and bi-/trifurcated.	Hydrogen	38-46	serpin family A member 2 (gene/pseudogene)	Homo sapiens	34-37
23450779-3	2013	The nature of the PIL"s hydrogen bonds reflects its macroscopic properties.	Hydrogen	24-32	serpin family A member 2 (gene/pseudogene)	Homo sapiens	18-21
23434549-5	2013	The interaction of tricin with residues in the hydrophobic pocket of tyrosinase was revealed by fluorescence quenching; the complex was stabilized by hydrophobic associations and hydrogen bonding (with residues Asn80 and Arg267).	Hydrogen	179-187	tyrosinase	Homo sapiens	69-79
23661516-8	2013	Hydrogen-rich saline treatment also significantly decreased mucus index, collagen deposition, and expression of MUC5AC, collagen III and VEGF.	Hydrogen	0-8	vascular endothelial growth factor A	Mus musculus	137-141
23556735-0	2013	1H relaxation dispersion in solutions of nitroxide radicals: influence of electron spin relaxation.	Hydrogen	0-2	spindlin 1	Homo sapiens	83-87
23325700-8	2013	Binding mode analysis of potent inhibitors suggests that these compounds are well accommodated by the MAO-B active site through stable hydrophobic and hydrogen bonding interactions.	Hydrogen	151-159	monoamine oxidase B	Rattus norvegicus	102-107
23360431-5	2013	A predictive model was developed from the initial SAR in which the potency of the analogues correlated with the ability of the substituent in the 7-position of the azaindole to adopt a coplanar conformation by either forming internal hydrogen bonds or avoiding repulsive substitution patterns.	Hydrogen	234-242	sarcosine dehydrogenase	Homo sapiens	50-53
23343195-5	2013	Comparing phosphinic versus hydroxamate inhibitors reveals that the chelation of the zinc ion is slightly different, leading the inhibitor backbone to adopt a position in which the hydrogen bonding with the MMP-12 active site is less favorable in phosphinic inhibitor while maintaining high affinity.	Hydrogen	181-189	matrix metallopeptidase 12	Homo sapiens	207-213
23258532-2	2013	H(2) is generated mostly by the [Fe-Fe]-hydrogenase HYDA1, which uses plant type ferredoxin PETF/FDX1 (PETF) as an electron donor.	Hydrogen	0-4	ferredoxin 1	Homo sapiens	97-101
23256664-2	2013	By adjusting the CO(2)-to-steam ratio in the gas feed, the H(2)/CO ratio in the produced syn-gas could be easily adjusted in a single step to the desired value of 2 for methanol and hydrocarbon synthesis.	Hydrogen	59-63	synemin	Homo sapiens	89-92
24148794-9	2013	Moreover, H2 treatment dose-dependently attenuated the increased levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta, HMGB1), but further increased the level of anti-inflammatory cytokine IL-10 at 3 h, 6 h, 12 h and 24 h after LPS stimulation.	Hydrogen	10-12	interleukin 10	Homo sapiens	194-199
23089916-0	2013	Structural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometry.	Hydrogen	74-82	phospholipase A2 group VII	Homo sapiens	45-52
23089916-5	2013	We have now employed hydrogen deuterium exchange mass spectrometry to characterize the interaction between recombinant human Lp-PLA(2) and human HDL.	Hydrogen	21-29	phospholipase A2 group VII	Homo sapiens	125-134
23559827-8	2013	After extensive and controlled in silico analysis it has been observed that the analogue LOPI1 binds to Nef protein (2NEF) at CD4 interacting site residues giving minimum binding energy of -7.68 Kcal/mole, low Ki value of 2.34 muM, maximum number of hydrogen bonds (8), good absorption, distribution, metabolism and excretion properties, and less toxicity in comparison with the standard Lopinavir against HIV1 protease (1HPV).	Hydrogen	250-258	Nef	Human immunodeficiency virus 1	104-107
23559827-8	2013	After extensive and controlled in silico analysis it has been observed that the analogue LOPI1 binds to Nef protein (2NEF) at CD4 interacting site residues giving minimum binding energy of -7.68 Kcal/mole, low Ki value of 2.34 muM, maximum number of hydrogen bonds (8), good absorption, distribution, metabolism and excretion properties, and less toxicity in comparison with the standard Lopinavir against HIV1 protease (1HPV).	Hydrogen	250-258	Nef	Human immunodeficiency virus 1	118-121
23153812-4	2012	The substituent on the alpha-carbon to the N1-hydrazine moiety (methyl or hydrogen) had a great influence on the activity and hMAO-B selectivity.	Hydrogen	74-82	monoamine oxidase B	Homo sapiens	126-132
23224743-6	2012	The mutations at residues P193A and Q199G of MMP-9 alternate the binding pattern of the C-terminal of APP-IP by forming two new hydrogen bonds and hydrophobic interactions with MMP-9.	Hydrogen	128-136	matrix metallopeptidase 9	Homo sapiens	45-50
22687249-4	2012	Under microaerobic conditions in the light, induced by sulphur-deprivation, knock-down of PFL1 resulted in reduced formate and ethanol production, increased net consumption of acetate and the excretion of lactate but no increase in the production of hydrogen.	Hydrogen	250-258	uncharacterized protein	Chlamydomonas reinhardtii	90-94
23030502-3	2012	The X-ray structure of representative inhibitors bound to BACE-1 revealed a number of key ligand:protein interactions, including a hydrogen bond between the side chain amide of flap residue Gln73 and the acyl guanidine carbonyl group, and a cation-pi interaction between Arg235 and the isothiazole 4-methoxyphenyl substituent.	Hydrogen	131-139	beta-secretase 1	Rattus norvegicus	58-64
22957734-0	2012	Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin.	Hydrogen	0-8	vitronectin	Homo sapiens	153-166
8652508-2	1996	d(CTTCTTGTCCG) and X7 in d(CGGACAXGAAG).d(CTTCTTGTCCG), incorporating codons 60, 61 (underlined), and 62 of the human n-ras protooncogene, were examined by 1H NMR.	Hydrogen	156-158	NRAS proto-oncogene, GTPase	Homo sapiens	118-123
22957734-0	2012	Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin.	Hydrogen	0-8	vitronectin	Homo sapiens	177-188
22692459-2	2012	Results showed that Al 1 nm sample had the best absorption kinetics and excellent optical properties at room temperature, making it a promising candidate for hydrogen sensors and smart windows.	Hydrogen	158-166	ephrin A5	Homo sapiens	20-24
8664278-1	1996	The backbone dynamics of the coiled-coil leucine zipper domain of c-Jun have been studied using proton-detected two-dimensional 1H-15N NMR spectroscopy.	Hydrogen	128-130	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-71
22745359-5	2012	Our docking studies suggested that anacardic acid binds into the MMP-2/9 active site, with the carboxylate group of anacardic acid chelating the catalytic zinc ion and forming a hydrogen bond to a key catalytic glutamate side chain and the C15 aliphatic group being accommodated within the relatively large S1" pocket of these gelatinases.	Hydrogen	178-186	matrix metallopeptidase 2	Mus musculus	65-70
8867213-2	1996	Single crystal x-ray diffraction studies reveal that a 3(10)-helix is formed up to the penultimate Aib residue, at which point there is a helix reversal in the backbone, reminiscent of a C-terminal 6--&gt;1 hydrogen bond.	Hydrogen	207-215	ANIB1	Homo sapiens	99-102
8639494-0	1996	Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II.	Hydrogen	16-24	carbonic anhydrase 2	Homo sapiens	138-159
8639494-7	1996	We propose that the E117Q substitution reverses the polarity of the residue 117-H119 hydrogen bond, thereby stabilizing H119 as a histidinate anion in the E117Q CAII holoenzyme.	Hydrogen	85-93	carbonic anhydrase 2	Homo sapiens	161-165
8615751-7	1996	c-N-I and c-N-II varied with respect to the following interactions with substrate: (1) hydrogen-bond formation with the substituent in the 6-position of the purine ring (a donor-type with c-N-I and an acceptor-type with c-N-II); and (2) hydrophobic attraction of the 6-position unsubstituted purine ring (more pronounced with c-N-I than with c-N-II).	Hydrogen	87-95	5'-nucleotidase, cytosolic II	Homo sapiens	10-16
10060591-0	1996	Spin exchange and recombination in a gas of atomic hydrogen at 1.2 K.	Hydrogen	51-59	spindlin 1	Homo sapiens	0-4
8616268-1	1996	1H, 15N and 13C resonance assignments are presented for the group II phospholipase A2 (PLA2) from Agkistrodon piscivorus piscivorus.	Hydrogen	0-2	phospholipase A2 group IIA	Homo sapiens	87-91
8652545-6	1996	The energetic cost of removal of hydroxyl groups at the C-9 and C-14 positions (which structural studies indicate may participate in hydrogen-bonding interactions with the DNA) was approximately 1 kcal mol(-1).	Hydrogen	133-141	complement C9	Homo sapiens	56-59
22969514-1	2012	In the crystal structure of the 1:1 title salt, C(4)H(12)NO(2) (+) C(6)H(4)BrO(-), hydrogen-bonding inter-actions originate from the ammonium cation, which adopts a syn conformation.	Hydrogen	83-91	synemin	Homo sapiens	165-168
22717721-5	2012	The value  J(AD)/k(B) =0.8 K between neighboring copper atoms at 4.942 A is assigned to a syn-anti equatorial-apical carboxylate bridge with a total bond length of 6.822 A, while the small value  J(AB)/k(B) =0.004 K is assigned to a long bridge of 11 atoms with a total bond length of 19.186 A, that includes one resonance assisted hydrogen bond (RAHB).	Hydrogen	332-340	synemin	Homo sapiens	90-93
22570080-9	2012	Phe173 and Glu174 located in EL2 were determined to be involved in ligand-receptor interactions through pi-pi stacking and hydrogen bonding.	Hydrogen	123-131	spectrin alpha, erythrocytic 1	Homo sapiens	29-32
22741781-7	2012	Docking studies revealed that all compounds (1-13) interacted mainly with residues II-S6 of NaV1.2 by making hydrogen bonds and additional hydrophobic interactions with domain I and II in the channel"s inner pore.	Hydrogen	109-117	sodium voltage-gated channel alpha subunit 2	Homo sapiens	92-98
22904573-5	2012	Both complexes reacted faster with 5"-GMP; however, analysis of the rate constants suggests that the [Pt(en)(D(2)O)(2)](2+) complex favors reaction with 5"-GMP due to hydrogen bonding with the 5"-phosphate, whereas [Pt(Me(4)en)(D(2)O)(2)](2+) disfavors reaction with N-AcMet due to steric clashes.	Hydrogen	167-175	5'-nucleotidase, cytosolic II	Homo sapiens	38-41
8654420-1	1996	In a previous paper, we reported on the structural properties of a 35-residue peptide corresponding to a modified basic subdomain (bSD) of the basic zipper protein c-Jun (residues 252-281) as determined by combined use of 1H-NMR, circular dichroism (CD) and Fourier transform infrared (FT-IR) spectroscopies [Krebs, D., Dahmani, B., El Antri, S., Monnot, M., Convert, O,.	Hydrogen	222-224	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	164-169
8673615-1	1996	The 8-hydroxyguanine:adenine mispairing scheme that spontaneously occurs in vivo through oxidative metabolism of DNA was edited to obtain a pair closely fitting the Watson-Crick geometry in which 2 purine bases of identical structure but oppositely rotated in the syn and anti configurations are hydrogen-bonded.	Hydrogen	296-304	synemin	Homo sapiens	264-267
8748713-5	1995	In all the analogs, the structure of the N-terminal region (residues 1-5) was different from the structure of motilin 1-12, which is characterized by hydrogen bonding between Phe1 and Ile4.	Hydrogen	150-158	motilin	Homo sapiens	110-117
8746786-6	1995	Third, all IFN-tau, as well as the related IFN-omega, possess a Gly at position 126 (rather than the equivalent Arg on MuIFN-beta and IFN-alpha) that will impair an extensive hydrogen bonding interaction between helix D and loop AB.	Hydrogen	175-183	interferon-tau-like	Bos taurus	11-18
8520225-3	1995	To avoid dephasing of the two-spin coherence caused by 1H-1H J-couplings, the 1H spin is locked by the application of a weak rf field, resulting in a spin-locked multiple quantum coherence.	Hydrogen	58-60	spindlin 1	Homo sapiens	30-34
8520225-3	1995	To avoid dephasing of the two-spin coherence caused by 1H-1H J-couplings, the 1H spin is locked by the application of a weak rf field, resulting in a spin-locked multiple quantum coherence.	Hydrogen	58-60	spindlin 1	Homo sapiens	81-85
8520225-3	1995	To avoid dephasing of the two-spin coherence caused by 1H-1H J-couplings, the 1H spin is locked by the application of a weak rf field, resulting in a spin-locked multiple quantum coherence.	Hydrogen	58-60	spindlin 1	Homo sapiens	81-85
7577994-1	1995	Two-dimensional 1H NMR spectra of an analog of reduced BPTI at pH 4.5, 1 degrees C, have been assigned.	Hydrogen	16-18	spleen trypsin inhibitor I	Bos taurus	55-59
22904573-5	2012	Both complexes reacted faster with 5"-GMP; however, analysis of the rate constants suggests that the [Pt(en)(D(2)O)(2)](2+) complex favors reaction with 5"-GMP due to hydrogen bonding with the 5"-phosphate, whereas [Pt(Me(4)en)(D(2)O)(2)](2+) disfavors reaction with N-AcMet due to steric clashes.	Hydrogen	167-175	5'-nucleotidase, cytosolic II	Homo sapiens	156-159
22842399-3	2012	Upon dehydriding, MgH(2) first decomposed to convert to Mg and liberate hydrogen with an on-set temperature of ~290  C. Subsequently, LiBH(4) reacted with CaH(2) to form CaB(6) and LiH in addition to further hydrogen release.	Hydrogen	72-80	neural proliferation, differentiation and control 1	Homo sapiens	170-173
22842399-3	2012	Upon dehydriding, MgH(2) first decomposed to convert to Mg and liberate hydrogen with an on-set temperature of ~290  C. Subsequently, LiBH(4) reacted with CaH(2) to form CaB(6) and LiH in addition to further hydrogen release.	Hydrogen	208-216	neural proliferation, differentiation and control 1	Homo sapiens	170-173
22793372-2	2012	SAR studies revealed a small structural change (ethyl group to hydrogen) caused a functional shift from antagonist to agonist activity (37, EC(50) = 170 nM), suggesting an interaction at a critical site for controlling gating of KCNQ2 channels.	Hydrogen	63-71	sarcosine dehydrogenase	Homo sapiens	0-3
22793372-2	2012	SAR studies revealed a small structural change (ethyl group to hydrogen) caused a functional shift from antagonist to agonist activity (37, EC(50) = 170 nM), suggesting an interaction at a critical site for controlling gating of KCNQ2 channels.	Hydrogen	63-71	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	229-234
22656649-6	2012	This suggests that the hydrogen bond interactions between TM3 and TM6 or between TM5 and TM6 may play a role in activating this GPCR.	Hydrogen	23-31	tropomyosin 3	Homo sapiens	58-61
7578246-7	1995	Tilted bases could reflect a conformational change that RecA imposes also on the biological intermediate triplex structure to relax the base-base hydrogen bonding between the DNA strands.	Hydrogen	146-154	RAD51 recombinase	Homo sapiens	56-60
22656649-9	2012	Thus it appears that the hydrogen bond interaction between TM3 and TM6 may activate the receptor to pass the ligand binding signal to intracellular processes and that the H-bond between agonists and residue 262 in tasters is involved in the bitter tasting.	Hydrogen	25-33	tropomyosin 3	Homo sapiens	59-62
22686511-6	2012	Mutagenesis studies on the core Aib residue involved in a seemingly key CH-pi-CH sandwich reported on how CH-pi interactions and inter-ring hydrogen bonds affect stability.	Hydrogen	140-148	ANIB1	Homo sapiens	32-35
22580067-0	2012	The combination of hydrogen/deuterium exchange or chemical cross-linking techniques with mass spectrometry: mapping of human 14-3-3zeta homodimer interface.	Hydrogen	19-27	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	125-135
7487913-0	1995	Dependence of in vivo glutamine synthetase activity on ammonia concentration in rat brain studied by 1H - 15N heteronuclear multiple-quantum coherence-transfer NMR.	Hydrogen	101-103	glutamate-ammonia ligase	Rattus norvegicus	22-42
22592884-4	2012	The electron-donor/-acceptor (EDA) complex of dodecanethiol (1) and cis-2 formed in a pre-equilibrium reacts with thiol 1 to give a stearyl and a sulfuranyl radical through molecule-assisted homolysis (MAH) of the sulfur-hydrogen bond.	Hydrogen	221-229	suppressor of cytokine signaling 2	Homo sapiens	68-73
8847078-11	1995	The presence in the TL antigen of the conserved amino acids, which in class I normally from hydrogen bonds with peptides, suggests that the TL antigen also can present nanomeric peptides.	Hydrogen	92-100	histocompatibility 2, T region locus 3	Mus musculus	20-30
8847078-11	1995	The presence in the TL antigen of the conserved amino acids, which in class I normally from hydrogen bonds with peptides, suggests that the TL antigen also can present nanomeric peptides.	Hydrogen	92-100	histocompatibility 2, T region locus 3	Mus musculus	140-150
7657098-5	1995	RESULTS: Perfusion of the antral sleeve lumen with media of increasing hydrogen ion concentration caused pH-dependent increases in CGRP and somatostatin release and decrease in gastrin release.	Hydrogen	71-79	gastrin	Rattus norvegicus	177-184
22441435-1	2012	The first recognition of the Hal(-)   HCH2NO2 (Hal = Cl, Br, I) hydrogen bonding.	Hydrogen	64-72	histidine ammonia-lyase	Homo sapiens	29-32
22441435-1	2012	The first recognition of the Hal(-)   HCH2NO2 (Hal = Cl, Br, I) hydrogen bonding.	Hydrogen	64-72	histidine ammonia-lyase	Homo sapiens	47-50
22441435-5	2012	The quantum-chemical calculations demonstrated that the short distance between the Hal(-) anion and the hydrogen atom of nitromethane in clusters [1][(Hal)(2)(MeNO(2))(2)] and [2][(Cl)(2)(MeNO(2))(2)] is not just a consequence of the packing effect but a result of the moderately strong hydrogen bonding.	Hydrogen	104-112	histidine ammonia-lyase	Homo sapiens	83-86
22441435-5	2012	The quantum-chemical calculations demonstrated that the short distance between the Hal(-) anion and the hydrogen atom of nitromethane in clusters [1][(Hal)(2)(MeNO(2))(2)] and [2][(Cl)(2)(MeNO(2))(2)] is not just a consequence of the packing effect but a result of the moderately strong hydrogen bonding.	Hydrogen	104-112	histidine ammonia-lyase	Homo sapiens	151-154
7667280-4	1995	CLIP fits identically into the MHC class II alleles HLA-DR3, I-Ak, I-Au, and I-Ad, with a consistent pattern of hydrogen bonds, contacts, and hydrophobic burial and without bad contacts.	Hydrogen	112-120	CAP-Gly domain containing linker protein 1	Homo sapiens	0-4
22441435-5	2012	The quantum-chemical calculations demonstrated that the short distance between the Hal(-) anion and the hydrogen atom of nitromethane in clusters [1][(Hal)(2)(MeNO(2))(2)] and [2][(Cl)(2)(MeNO(2))(2)] is not just a consequence of the packing effect but a result of the moderately strong hydrogen bonding.	Hydrogen	287-295	histidine ammonia-lyase	Homo sapiens	83-86
22667828-2	2012	In the ground state, this ruthenium complex combines a strong intercalative binding mode via the PHEHAT ligand, with TAP-mediated hydrogen bonding capabilities.	Hydrogen	130-138	nuclear RNA export factor 1	Homo sapiens	117-120
7649277-0	1995	1H NMR spectroscopy reveals that mouse Hsp25 has a flexible C-terminal extension of 18 amino acids.	Hydrogen	0-2	heat shock protein 1	Mus musculus	39-44
7649277-2	1995	Two-dimensional 1H NMR spectroscopy of mouse Hsp25 reveals that the last 18 amino acids have great flexibility with motion that is essentially independent of the domain core of the protein.	Hydrogen	16-18	heat shock protein 1	Mus musculus	45-50
22524464-3	2012	The amplitude of the resistance change induced by H(2) exposure and the time rate of change of the nanowire resistance both increased with increasing temperature from 298 to 550 K. This resistance decrease of the Pt nanowire in the presence of H(2) results from reduced electron diffuse scattering at hydrogen-covered Pt surfaces as compared with oxygen-covered platinum surfaces, we hypothesize.	Hydrogen	301-309	relaxin 2	Homo sapiens	244-248
7626622-4	1995	Previously, we have shown that Glu-34 is required for catalytic activity, presumably by forming a hydrogen bond between the carboxylate group of glutamate and the 2"-hydroxyl group of ribose in the AMP moiety of FAD.	Hydrogen	98-106	FA complementation group D2	Homo sapiens	212-215
22467876-6	2012	By employing molecular dynamics simulations of the EB1 interaction with a minimal CLASP2 plus-end-tracking module, we find that conserved arginine residues in CLASP2 form extensive hydrogen-bond networks with glutamate residues predominantly in the unstructured, acidic C-terminal tail of EB1.	Hydrogen	181-189	microtubule associated protein RP/EB family member 1	Homo sapiens	51-54
7548753-2	1995	This behavior led us to speculate that the pathway for the MAO-B catalyzed oxidation of these tetrahydropyridines may not necessarily proceed via an initial single electron transfer step as proposed by others but rather through an initial alpha-carbon hydrogen atom abstraction step.	Hydrogen	252-260	monoamine oxidase B	Homo sapiens	59-64
22489757-4	2012	Product analyses and kinetic data show that these reactions occur via rate-determining hydrogen-atom transfer (HAT), with a linear correlation for log k versus BDE(C-H), and the following activation parameters for xanthene (Xn) substrate: DeltaH(++) = 12.7 +- 0.8 kcal mol(-1), DeltaS(++) = -9 +- 3 cal K(-1) mol(-1), and KIE = 5.7.	Hydrogen	87-95	homeobox D13	Homo sapiens	160-163
7557507-3	1995	METHODS: We measured CBF in a rabbit model of transient complete obstruction of retinal vessels induced by intravitreal injection of a high dose of ET-1, using the hydrogen clearance method.	Hydrogen	164-172	endothelin-1	Oryctolagus cuniculus	148-152
22415204-6	2012	MD simulations and DFT calculations revealed that Gdm(+) ions could enter the active pocket of the GOx molecule and interact with the FAD group, leading to a significant alteration in the structural characteristics and hydrogen bond networks formed between FAD and the surrounding amino acid residues.	Hydrogen	219-227	hydroxyacid oxidase 1	Homo sapiens	99-102
7546038-10	1995	Because of the redox potential (-315 mV) and the distance between the pyridinium and phosphate groups, this analogue is a hydrogen acceptor and its reduced form a hydrogen donor in tests with alcohol dehydrogenase from Thermoanaerobium brockii.	Hydrogen	122-130	aldo-keto reductase family 1 member A1	Homo sapiens	192-213
7546038-10	1995	Because of the redox potential (-315 mV) and the distance between the pyridinium and phosphate groups, this analogue is a hydrogen acceptor and its reduced form a hydrogen donor in tests with alcohol dehydrogenase from Thermoanaerobium brockii.	Hydrogen	163-171	aldo-keto reductase family 1 member A1	Homo sapiens	192-213
7752204-7	1995	It is proposed that for good affinity and selectivity a hydrogen bond acceptor interaction with the 5-HT1D receptor, through a beta-nitrogen in the azole ring, is required.	Hydrogen	56-64	5-hydroxytryptamine receptor 1D	Homo sapiens	100-106
7537088-1	1995	1H NMR has been used to investigate the structural properties of RANTES, a protein from the C-C branch of the chemotactic cytokine family that has a strong chemoattractive effect on monocytes, lymphocytes, and eosinophils.	Hydrogen	0-2	C-C motif chemokine ligand 5	Homo sapiens	65-71
7721830-7	1995	We have solved the structure of one of the previously unidentified products as, GalNAc alpha(1,4)GlcA beta(1,3)Gal beta(1,3)Gal beta(1,4)Xyl beta MU, based on compositional analysis by high performance liquid chromatography, fast atom bombardment, electrospray mass spectrometry, and one-dimensional and two-dimensional 1H NMR spectroscopy.	Hydrogen	320-322	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	102-110
7721830-7	1995	We have solved the structure of one of the previously unidentified products as, GalNAc alpha(1,4)GlcA beta(1,3)Gal beta(1,3)Gal beta(1,4)Xyl beta MU, based on compositional analysis by high performance liquid chromatography, fast atom bombardment, electrospray mass spectrometry, and one-dimensional and two-dimensional 1H NMR spectroscopy.	Hydrogen	320-322	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	115-123
7613470-2	1995	The 1H, 15N, and 13C magnetic resonances of the 67-amino acid long POUH of mouse Oct-3 have almost completely been assigned, mainly through the combined use of three-dimensional triple resonance NMR methods.	Hydrogen	4-6	POU domain, class 5, transcription factor 1	Mus musculus	81-86
7700259-4	1995	The biologically active conformers of both carcinogenic stereoisomers (anti and syn) of triol carbocations are characterized by a quasi-diaxial orientation of the neighboring hydroxyl groups and fulfill the spatial requirements for hydrogen bonding to the adjacent guanine residues of B-DNA.	Hydrogen	232-240	synemin	Homo sapiens	80-83
9979255-0	1995	Hydrogen passivation of EL2 defects and H2*-like complex formation in gallium arsenide.	Hydrogen	0-8	spectrin alpha, erythrocytic 1	Homo sapiens	24-27
7531249-0	1995	Hydrogen exchange and protein hydration: the deuteron spin relaxation dispersions of bovine pancreatic trypsin inhibitor and ubiquitin.	Hydrogen	0-8	spleen trypsin inhibitor I	Bos taurus	85-120
7531249-4	1995	The pD dependence of the 2H relaxation in BPTI solutions could be quantitatively accounted for in terms of known pK values and hydrogen exchange rate constants.	Hydrogen	127-135	spleen trypsin inhibitor I	Bos taurus	42-46
7696549-4	1995	In both peptides the observed (N...O) distances between the Boc CO and Ala (3) NH groups are far too long (I: 3.44 A; III: 3.63 A) for an intramolecular 4--&gt;1 hydrogen bond.	Hydrogen	162-170	BOC cell adhesion associated, oncogene regulated	Homo sapiens	60-63
7993913-0	1994	Hydrogen tunneling in the flavoenzyme monoamine oxidase B.	Hydrogen	0-8	monoamine oxidase B	Homo sapiens	38-57
7535606-8	1994	Overall, this work showed that certain H2 antagonists activate an unstable form of tyrosinase in amelanotic melanoma cells by a post-transcriptional mechanism dependent on protein synthesis.	Hydrogen	39-41	tyrosinase	Homo sapiens	83-93
7538845-0	1994	Hydrogen exchange in BPTI variants that do not share a common disulfide bond.	Hydrogen	0-8	spleen trypsin inhibitor I	Bos taurus	21-25
7800509-2	1994	1H NOESY experiments show that the 5"-GMP adopts the syn conformation about the glycosidic bond.	Hydrogen	0-2	5'-nucleotidase, cytosolic II	Homo sapiens	38-41
7800509-2	1994	1H NOESY experiments show that the 5"-GMP adopts the syn conformation about the glycosidic bond.	Hydrogen	0-2	synemin	Homo sapiens	53-56
7961686-4	1994	This protein is the first peroxidase to be identified that uses thioredoxin as the immediate hydrogen donor and is thus named thioredoxin peroxidase (TPx).	Hydrogen	93-101	thyroid peroxidase	Homo sapiens	126-148
7961686-4	1994	This protein is the first peroxidase to be identified that uses thioredoxin as the immediate hydrogen donor and is thus named thioredoxin peroxidase (TPx).	Hydrogen	93-101	thyroid peroxidase	Homo sapiens	150-153
7703841-0	1994	Fast folding of a prototypic polypeptide: the immunoglobulin binding domain of streptococcal protein G. The folding of the small (56 residues) highly stable B1 immunoglobulin binding domain (GB1) of streptococcal protein G has been investigated by quenched-flow deuterium-hydrogen exchange.	Hydrogen	272-280	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	191-194
7932521-4	1994	Computer modeling of A-74273 bound to renin indicated that the C-terminus was involved in a hydrogen-bonding network.	Hydrogen	92-100	renin	Canis lupus familiaris	38-43
7932521-6	1994	Those groups which possessed multiple hydrogen-bonding ability (3,5-diaminotriazole, cyanoguanidines, morpholino) provided particularly potent renin binding.	Hydrogen	38-46	renin	Canis lupus familiaris	143-148
8086411-0	1994	Annexin V binding to the outer leaflet of small unilamellar vesicles leads to altered inner-leaflet properties: 31P- and 1H-NMR studies.	Hydrogen	121-123	annexin A5	Rattus norvegicus	0-9
7984059-0	1994	Band-selective spin echoes for in vivo localized 1H NMR spectroscopy.	Hydrogen	49-51	spindlin 1	Rattus norvegicus	15-19
7954512-8	1994	The molecules are linked in the crystal through intermolecular hydrogen-bonding interactions that involve the two hydroxyl groups, OH-3 and OH-5", and the isopropylidene ring oxygen atoms, O-2 and O-1", as donor and acceptor, respectively.	Hydrogen	63-71	immunoglobulin kappa variable 1D-39	Homo sapiens	189-201
8203892-1	1994	Histidine at position 51 of the class I beta 1 alcohol dehydrogenase (ADH) functions as a general base by indirectly abstracting a proton from the alcohol substrate through a hydrogen-bonded proton relay system.	Hydrogen	57-65	aldo-keto reductase family 1 member A1	Homo sapiens	70-73
8020468-18	1994	Spectroelectrochemical oxidoreductive titrations gave E"o (versus standard hydrogen electrode) = +322 mV for the cytochrome b and +280 mV for the cytochrome c component.	Hydrogen	75-83	cytochrome b	Pseudomonas stutzeri	113-125
8312269-2	1994	In order to gain insights into the PPIase mechanism, transferred nuclear Overhauser effect (TRNOE) measurements by two-dimensional 1H NMR were used to determine the conformation of the isomerase-bound standard model substrate suc-AAPF-pNA.	Hydrogen	131-133	peptidylprolyl isomerase like 1	Homo sapiens	35-41
8253762-4	1993	A highly ordered, electrostatic network containing 7 hydrogen (H)-bonds links the OE1 and OE2 atoms of myristate"s carboxylate group, the indole nitrogen of Trp82, NH1, and NH2 of Arg106, NE2, and OE1 of Gln115, and 2 interior ordered waters.	Hydrogen	53-61	EBF transcription factor 1	Rattus norvegicus	82-85
8253762-4	1993	A highly ordered, electrostatic network containing 7 hydrogen (H)-bonds links the OE1 and OE2 atoms of myristate"s carboxylate group, the indole nitrogen of Trp82, NH1, and NH2 of Arg106, NE2, and OE1 of Gln115, and 2 interior ordered waters.	Hydrogen	53-61	EBF transcription factor 1	Rattus norvegicus	197-200
8259052-5	1993	These results indicate that 1H MRS identifies abnormal colorectal mucosa, which is not morphologically manifest.	Hydrogen	28-30	MROS	Homo sapiens	31-34
8259052-7	1993	Collectively, these results suggest that a clinical study of colorectal biopsies by 1H MRS could provide support for the use of MRS as an adjunct to current pathological procedures.	Hydrogen	84-86	MROS	Homo sapiens	87-90
8259052-7	1993	Collectively, these results suggest that a clinical study of colorectal biopsies by 1H MRS could provide support for the use of MRS as an adjunct to current pathological procedures.	Hydrogen	84-86	MROS	Homo sapiens	128-131
7995481-5	1993	During exposure to hydrogen, the evaporation rate appeared to exceed the limit of the gold film mercury analyzer (284 pg/mm2/s), but was rapidly reduced upon exposure to air.	Hydrogen	19-27	PNMA family member 2	Homo sapiens	121-124
8401230-0	1993	Bacterial expression and characterization of the CREB bZip module: circular dichroism and 2D 1H-NMR studies.	Hydrogen	93-95	cAMP responsive element binding protein 1	Homo sapiens	49-58
8401230-8	1993	In addition, the two-dimensional (2D) 1H-NMR studies of the bZip CREB peptide further support the distinct features of the CREB protein, in comparison to GCN4.	Hydrogen	38-40	cAMP responsive element binding protein 1	Homo sapiens	65-69
8391867-1	1993	The regulation of junctional conductance (Gi) of the major cardiac (connexin43; Cx43) and liver (connexin32; Cx32) gap junction proteins by intracellular hydrogen ion concentration (pH; pHi), as well as well as that of a truncation mutant of Cx43 (M257) with 125 amino acids deleted from the COOH terminus, was characterized in pairs of Xenopus laevis oocytes expressing homologous channels.	Hydrogen	154-162	gap junction protein alpha 1 S homeolog	Xenopus laevis	68-78
8391867-1	1993	The regulation of junctional conductance (Gi) of the major cardiac (connexin43; Cx43) and liver (connexin32; Cx32) gap junction proteins by intracellular hydrogen ion concentration (pH; pHi), as well as well as that of a truncation mutant of Cx43 (M257) with 125 amino acids deleted from the COOH terminus, was characterized in pairs of Xenopus laevis oocytes expressing homologous channels.	Hydrogen	154-162	gap junction protein alpha 1 S homeolog	Xenopus laevis	80-84
8487302-8	1993	The substitution of Glu59, which is preserved in all the determined species of parvalbumin, by Asp59 in oncomodulin seems to break a stabilizing hydrogen bond in the CD loop and render the main-chain in positions 59 to 60 somewhat unstable.	Hydrogen	145-153	parvalbumin	Rattus norvegicus	79-90
8381060-3	1993	METHODS AND RESULTS: We examined 1) the effects of HS on ANP- or brain natriuretic peptide (BNP)-induced reductions in renal vascular resistance (RVR) of rat isolated perfused kidneys, 2) the effects of HS on cyclic GMP (cGMP) production in rat cultured vascular smooth muscle cells pretreated with ANP or BNP, and 3) the renal and systemic effects of HS in DOCA-salt-treated rats and control rats.	Hydrogen	51-53	natriuretic peptide A	Rattus norvegicus	57-60
8381060-4	1993	We found that 1) HS dose-dependently reversed ANP- or BNP-induced decreases in RVR; 2) ANP or BNP at 100 nM caused an eightfold increase in cGMP production.	Hydrogen	17-19	natriuretic peptide A	Rattus norvegicus	46-49
8345788-1	1993	Spin-echo sequences with echo times as short as 3.5 msec were implemented on a standard 1.5 T NMR whole-body imager for 1H imaging of polymers in the solid-state.	Hydrogen	120-122	spindlin 1	Homo sapiens	0-4
1281542-2	1992	Assignments of nearly all 1H and 15N resonances of the SH2 domain from the c-Abl protein-tyrosine kinase have been obtained from homonuclear and heteronuclear NMR experiments.	Hydrogen	26-28	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	75-80
1333795-0	1992	Gene synthesis, bacterial expression, and 1H NMR spectroscopic studies of the rat outer mitochondrial membrane cytochrome b5.	Hydrogen	42-44	cytochrome b5 type A	Rattus norvegicus	111-124
1333795-6	1992	The recombinant OM cytochrome b5 was characterized by UV-visible, EPR, and 1H NMR spectroscopy.	Hydrogen	75-77	cytochrome b5 type A	Rattus norvegicus	19-32
1333795-12	1992	The one-dimensional 1H NMR spectrum of the OM cytochrome b5 indicates that the rhombic perturbation of the ferric center is essentially identical to that in the microsomal beef, rabbit, chicken, and rat cytochromes b5.	Hydrogen	20-22	cytochrome b5	Oryctolagus cuniculus	46-59
1335082-4	1992	The derivatives with a hydrogen or methyl group at C-1, fluorine at C-6, and piperazinyl or 4-methyl-1-piperazinyl group at C-7 showed superior in vitro antibacterial activity, and the derivatives with 4-methyl-1-piperazinyl group at C-7 had potent in vivo activity.	Hydrogen	23-31	complement C7	Homo sapiens	124-127
1335082-4	1992	The derivatives with a hydrogen or methyl group at C-1, fluorine at C-6, and piperazinyl or 4-methyl-1-piperazinyl group at C-7 showed superior in vitro antibacterial activity, and the derivatives with 4-methyl-1-piperazinyl group at C-7 had potent in vivo activity.	Hydrogen	23-31	complement C7	Homo sapiens	234-237
1445921-6	1992	Moreover, Ca2+ binding weakened the hydrogen bonding of the polar head region of SGC and the hydrocarbon chains became more disordered as revealed by an increase in the correlation field splitting pressure of SGC.	Hydrogen	36-44	carbonic anhydrase 2	Homo sapiens	10-13
1472646-1	1992	The conformation of oxytocin, the neurohypophyseal nonapeptide hormone, in solution in deuterated dimethyl sulfoxide has been determined by 1H-nmr.	Hydrogen	140-142	oxytocin/neurophysin I prepropeptide	Homo sapiens	20-28
1420331-0	1992	Interaction of calmodulin with phospholamban and caldesmon: comparative studies by 1H-NMR spectroscopy.	Hydrogen	83-85	CaM5	Triticum aestivum	15-25
1420331-5	1992	We contrast here a calmodulin-binding segment in the C-terminal region of caldesmon localised by 1H-NMR study of the interface(s) between the two proteins.	Hydrogen	97-99	CaM5	Triticum aestivum	19-29
1486654-5	1992	Coupling constants for rings A, B and C of delta 5,7 steroids are presented and stereochemical assignments have been made for the following 1H NMR signals: the C-11 protons of delta 5,7 steroids, the C-16 protons of sterols and bile acids, the C-22 and C-23 protons of bile acid esters and the C-28 protons of stigmasterol derivatives.	Hydrogen	140-142	RNA polymerase III subunit K	Homo sapiens	160-164
1425696-7	1992	500-MHz one-dimensional and two-dimensional 1H-NMR spectroscopy revealed their structures to be Sia alpha(2-3)Gal beta(1-4) [HSO3-6]GlcNAc beta(1-3)Gal and HSO3-6GlcNAc beta(1-3)Gal, showing that the sulfate-containing acidic chains are constructed with non-branched N-acetyllactosamine repeats which have sialic acid(s) at the non-reducing end(s) and sulfate at the C-6 position of GlcNAc residues.	Hydrogen	44-46	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	139-147
1336012-0	1992	1H-NMR study of Ca(2+)-and Mg(2+)-dependent interaction between troponin C and troponin I inhibitory peptide (96-116).	Hydrogen	0-2	tenascin	Oryctolagus cuniculus	64-74
1336012-1	1992	The Ca(2+)-and Mg(2+)-dependence of the interaction between rabbit skeletal muscle troponin C (TnC) and a 21 residue peptide corresponding to 96-116 of troponin I (denoted as CN4) was examined by means of 1H-NMR spectroscopy.	Hydrogen	205-207	tenascin	Oryctolagus cuniculus	83-93
1336012-1	1992	The Ca(2+)-and Mg(2+)-dependence of the interaction between rabbit skeletal muscle troponin C (TnC) and a 21 residue peptide corresponding to 96-116 of troponin I (denoted as CN4) was examined by means of 1H-NMR spectroscopy.	Hydrogen	205-207	tenascin	Oryctolagus cuniculus	95-98
1303761-1	1992	Backbone amide proton exchange rates in the DNA-binding domain of GAL4 have been determined using 1H-15N heteronuclear correlation NMR spectroscopy.	Hydrogen	98-100	galectin 4	Homo sapiens	66-70
1327881-1	1992	The heme propionate substituents in Pseudomonas cytochrome c-551 are partially buried by folds of polypeptide in the structure of the protein, and are involved in several hydrogen bonds.	Hydrogen	171-179	cytochrome c3 family protein	Pseudomonas stutzeri	48-60
1445998-3	1992	1H NMR spectral analyses revealed that two singlet signals of olefinic protons of N-methyldehydroalanine (Mdha) in microcystins disappeared in the conjugates, confirming that thiols of GSH and Cys added nucleophilically to the alpha, beta-unsaturated carbonyl of the Mdha moiety.	Hydrogen	0-2	malate dehydrogenase 1, NAD (soluble)	Mus musculus	106-110
1333263-2	1992	Cancers have typical metabolic characteristics in 31P and 1H MRS including high levels of phospholipid metabolites and a cellular pH more alkaline than normal.	Hydrogen	58-60	MROS	Homo sapiens	61-64
1449968-9	1992	1H-MRS has been used to demonstrate the presence of the cyclobutanedicarboxylate leaving group, both free and platinum bound, in the urine of patients treated with carboplatin.	Hydrogen	0-2	MROS	Homo sapiens	3-6
1518046-8	1992	These thrombin structures confirm previous conclusions of the important role of the intermolecular hydrogen bonds formed with Gly216, and of the good sterical fit of the terminal bulky hydrophobic inhibitor groups with the hydrophobic aryl binding site and the S2-cavity, respectively, for tight thrombin active site binding of these non-peptidic inhibitors.	Hydrogen	99-107	coagulation factor II, thrombin	Bos taurus	6-14
1599930-1	1992	We have measured the frequency of the carbon-hydrogen stretching mode of the pro-R and pro-S C4-H bonds of NADH in solution and when bound to pig heart lactate (LDH) or mitochondrial malate (mMDH) dehydrogenases.	Hydrogen	45-53	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	191-195
1599944-1	1992	1H-NMR spectroscopy is employed to study the interaction between rabbit skeletal muscle troponin (C (TnC) and wasp venom tetradecapeptide mastoparan.	Hydrogen	0-2	tenascin	Oryctolagus cuniculus	65-105
1531295-0	1992	Mechanism of C-3 hydrogen exchange and the elimination of ammonia in the 3-methylaspartate ammonia-lyase reaction.	Hydrogen	17-25	complement C3	Homo sapiens	13-16
1531295-1	1992	The enzyme 3-methylaspartate ammonia-lyase (EC 4.3.1.2) catalyzes the exchange of the C-3 hydrogen of the substrate, (2S,3S)-3-methylaspartic acid, with solvent hydrogen.	Hydrogen	90-98	complement C3	Homo sapiens	86-89
1531295-1	1992	The enzyme 3-methylaspartate ammonia-lyase (EC 4.3.1.2) catalyzes the exchange of the C-3 hydrogen of the substrate, (2S,3S)-3-methylaspartic acid, with solvent hydrogen.	Hydrogen	161-169	complement C3	Homo sapiens	86-89
1731762-4	1992	Moreover, NADPH may be replaced by reduced RNAase as a hydrogen donor.	Hydrogen	55-63	2,4-dienoyl-CoA reductase 1	Homo sapiens	10-15
1939232-3	1991	Some 1H NMR resonances are assigned for both protein and DNA in the Cro-operator DNA complexes which are then used to highlight differences between Cro right half and Cro left half protein-operator DNA interactions.	Hydrogen	5-7	cro	Escherichia virus Lambda	68-71
1939232-3	1991	Some 1H NMR resonances are assigned for both protein and DNA in the Cro-operator DNA complexes which are then used to highlight differences between Cro right half and Cro left half protein-operator DNA interactions.	Hydrogen	5-7	cro	Escherichia virus Lambda	148-151
1939232-3	1991	Some 1H NMR resonances are assigned for both protein and DNA in the Cro-operator DNA complexes which are then used to highlight differences between Cro right half and Cro left half protein-operator DNA interactions.	Hydrogen	5-7	cro	Escherichia virus Lambda	148-151
1960732-0	1991	Two-dimensional 1H nuclear magnetic resonance study of the (5-55) single-disulphide folding intermediate of bovine pancreatic trypsin inhibitor.	Hydrogen	16-18	spleen trypsin inhibitor I	Bos taurus	108-143
1960733-2	1991	We have used two-dimensional 1H nuclear magnetic resonance spectroscopy to determine the structure of the synthetic inhibitory peptide N alpha-acetyl TnI(104-115) amide bound to calcium-saturated skeletal troponin C (TnC).	Hydrogen	29-31	tenascin C	Homo sapiens	205-215
22413941-7	2012	To characterize the atomistic failure modes of ettringite, we performed stress-strain simulations to find that Ca-O bonds are responsible for failure of the calcium sulfate and tricalcium aluminate (C3A) column in ettringite during uniaxial compression and tension and that hydrogen bond re-formation during compression induces an increase in plastic strain beyond the material"s stress-strain proportionality limit.	Hydrogen	274-282	complement C3	Homo sapiens	199-202
1812067-5	1991	In the RNase T1-GpC complex, the 2"-OH group is in close proximity to the side chain carboxylic acid of Glu58 which leads to the formation of a hydrogen bond.	Hydrogen	144-152	glycophorin C (Gerbich blood group)	Homo sapiens	16-19
1821811-9	1991	1H NMR is used to analyze the N-extended BPTI analogues.	Hydrogen	0-2	spleen trypsin inhibitor I	Bos taurus	41-45
22482589-1	2012	Solvent effect on protein conformation and folding mechanism of E6-associated protein (E6ap) peptide are investigated using a recently developed charge update scheme termed as adaptive hydrogen bond-specific charge (AHBC).	Hydrogen	185-193	ubiquitin protein ligase E3A	Homo sapiens	64-85
1714521-4	1991	Preculture of bone marrow-derived macrophages (BMM) from BALB/c (If-1l) mice in macrophage colony-stimulating factor plus anti-IFN-beta provoked a 30- to 50-fold increase in NDV-induced cytokine production compared with induced control cultures in macrophage colony-stimulating factor alone, whereas only a 4- to 6-fold increase was observed in anti-IFN-beta-treated BMM from C57BL/6 (If-1h) mice.	Hydrogen	388-390	interferon beta 1, fibroblast	Mus musculus	127-135
22482589-1	2012	Solvent effect on protein conformation and folding mechanism of E6-associated protein (E6ap) peptide are investigated using a recently developed charge update scheme termed as adaptive hydrogen bond-specific charge (AHBC).	Hydrogen	185-193	ubiquitin protein ligase E3A	Homo sapiens	87-91
22241629-7	2012	A significant dose-dependent induction in reactive oxygen species (ROS) and early response markers (c-Fos, c-Jun, and GAP-43) were observed in cells exposed to 4-HNE (10, 25, and 50 microM) for 1h.	Hydrogen	194-196	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	100-105
1653449-3	1991	DNA sequence discrimination by CAP derives both from sequence-dependent distortion of the DNA helix and from direct hydrogen-bonding interactions between three protein side chains and the exposed edges of three base pairs in the major groove of the DNA.	Hydrogen	116-124	catabolite gene activator protein	Escherichia coli	31-34
22020754-1	2012	The unicellular green alga Chlamydomonas reinhardtii is able to use photosynthetically provided electrons for the production of molecular hydrogen by an [FeFe]-hydrogenase HYD1 accepting electrons from ferredoxin PetF.	Hydrogen	138-146	uncharacterized protein	Chlamydomonas reinhardtii	172-176
1868851-3	1991	From the dependence between the 1H-NMR chemical shifts of H-2 (where applicable), H-8, and H-1", and the pD of the solutions, the acidity constants for the deprotonation of the D+(N-7) site in D2(ITP)2-, D2(GTP)2-, D(Ino)+, and D(Guo)+, and of the D+(N-1) site in D2(ATP)2- and D(Ado)+ were calculated.	Hydrogen	32-34	relaxin 2	Homo sapiens	58-61
22020754-2	2012	Despite the severe sensitivity of HYD1 towards oxygen, a sustained and relatively high photosynthetic hydrogen evolution capacity is established in C. reinhardtii cultures when deprived of sulfur.	Hydrogen	102-110	uncharacterized protein	Chlamydomonas reinhardtii	34-38
9906188-0	1991	Spin asymmetry in electron-impact ionization of hydrogen atoms close to threshold.	Hydrogen	48-56	spindlin 1	Homo sapiens	0-4
26286151-3	2012	In guanosine, syn conformation is preferred as a result of internal hydrogen bonding between the 5"-OH group of the sugar and the N3 site of the guanine moiety.	Hydrogen	68-76	synemin	Homo sapiens	14-17
1854720-3	1991	As a first step toward answering this question, we have recently described the sequential 1H NMR assignment of a representative nonconsensus Zn finger (designated ZFY-6T) based on 2D NMR studies of a 30-residue peptide [Kochoyan, M., Havel, T.F., Nguyen, D.T., Dahl, C.E., Keutmann, H. T., &amp; Weiss, M.A.	Hydrogen	90-92	zinc finger protein Y-linked	Homo sapiens	163-166
22367848-0	2012	1H NMR spectroscopic identification of protonable sites in cryptolepines with C-11 substituents containing two amino functionalities.	Hydrogen	0-2	RNA polymerase III subunit K	Homo sapiens	78-82
1830036-4	1991	infusion of hANF (bolus 100 micrograms; infusion 100 micrograms/h, t = 1h) arterial and venous plasma concentrations of hANF increased about 10-fold (p less than 0.05), however, estimated leg blood flow as well as leg fractional extraction, leg uptake and clearance rates of hANF did not significantly change as compared to baseline.	Hydrogen	71-73	HESX homeobox 1	Homo sapiens	12-16
1899057-3	1991	The in vitro product, AFG1-lysine, was characterized by UV, fluorescence, 1H- and 13C-NMR spectroscopy and fast atom bombardment MS. A competitive enzyme-linked immunoassay for this adduct was established using polyclonal antibodies to AFB1 and this was used together with an HPLC-fluorescence technique to quantitate the in vivo formation of AFG1-albumin adducts in comparison to AFB1.	Hydrogen	74-76	AFG1 like ATPase	Homo sapiens	22-26
22176491-6	2012	The CMM-RS potential determined for OC-Cl2 was also used to compare quantitatively many of the inherent properties of this non-covalent halogen bonded complex with those of the closely related hydrogen-bonded complex OC-HCl, which has a similar dissociation energy D0.	Hydrogen	193-201	endogenous retrovirus group W member 5	Homo sapiens	39-42
22248451-0	2012	Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin.	Hydrogen	0-8	transthyretin	Homo sapiens	44-57
2271685-0	1990	Spin-echo 1H NMR studies of differential mobility in gizzard myosin and its subfragments.	Hydrogen	10-12	spindlin 1	Homo sapiens	0-4
22248451-0	2012	Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin.	Hydrogen	0-8	transthyretin	Homo sapiens	94-107
22248451-3	2012	Here we show the neutron structure of TTR, focusing on the hydrogen bonds, protonation states and pH sensitivities.	Hydrogen	59-67	transthyretin	Homo sapiens	38-41
22248451-7	2012	This hydrogen-bond network is composed of Thr75, Trp79, His88, Ser112, Pro113, Thr118-B and four water molecules, and is involved in both monomer-monomer and dimer-dimer interactions, suggesting that the double protonation of His88 by acidification breaks the hydrogen-bond network and causes the destabilization of the TTR tetramer.	Hydrogen	5-13	transthyretin	Homo sapiens	320-323
22248451-7	2012	This hydrogen-bond network is composed of Thr75, Trp79, His88, Ser112, Pro113, Thr118-B and four water molecules, and is involved in both monomer-monomer and dimer-dimer interactions, suggesting that the double protonation of His88 by acidification breaks the hydrogen-bond network and causes the destabilization of the TTR tetramer.	Hydrogen	260-268	transthyretin	Homo sapiens	320-323
2216754-3	1990	The syn-conformation of the guanine base of the mismatch is stabilised by hydrogen bonding to a network of solvent molecules in both the major and minor grooves.	Hydrogen	74-82	synemin	Homo sapiens	4-7
22208647-9	2012	A reliable increase in PKC phosphorylation was seen 7 min after drug injection, which declined to the normal level by 1h.	Hydrogen	118-120	protein kinase C, gamma	Rattus norvegicus	23-26
2134333-0	1990	Lactose tolerance hydrogen breath test (H2BT)	Hydrogen	18-26	H2B clustered histone 20, pseudogene	Homo sapiens	40-44
26592886-6	2012	The latter is caused by the change of topology of the hydrogen bonding network and the nature of the hydrogen bonds around the spin label induced by the hydrophobic cavity of the inclusion host.	Hydrogen	101-109	spindlin 1	Homo sapiens	127-131
2290834-6	1990	This seems to be the result of the stability of the five-membered ring that is formed by the carboxylate anion hydrogen bonded to a ligand water molecule and the metal ion in the syn position.	Hydrogen	111-119	synemin	Homo sapiens	179-182
22178760-10	2012	The syn-conformation of 8-oxoG is stabilized by minor groove hydrogen bonding between the side chain of Arg283 and O8 of 8-oxoG.	Hydrogen	61-69	synemin	Homo sapiens	4-7
2271562-0	1990	1H NMR assignment and melting temperature study of cis-syn and trans-syn thymine dimer containing duplexes of d(CGTATTATGC).d(GCATAATACG).	Hydrogen	0-2	synemin	Homo sapiens	55-58
2271562-0	1990	1H NMR assignment and melting temperature study of cis-syn and trans-syn thymine dimer containing duplexes of d(CGTATTATGC).d(GCATAATACG).	Hydrogen	0-2	synemin	Homo sapiens	69-72
2271562-6	1990	Analysis of the temperature dependence of the T5CH3 1H NMR signal gave delta H = 44 +/- 4 kcal and delta S = 132 +/- 13 eu for the trans-syn duplex.	Hydrogen	52-54	synemin	Homo sapiens	137-140
22119465-2	2012	After docking into a PDK1 X-ray structure it was suggested that the pyrimidine ring could be substituted for a purine thereby increasing the number of hydrophobic contacts with the protein and forming an additional hydrogen bond to the kinase hinge.	Hydrogen	215-223	pyruvate dehydrogenase kinase 1	Homo sapiens	21-25
2167851-2	1990	The concentration dependence of the chemical shifts for the hydrogens H-2, H-8 and H-1" of ITP and for H-8 and H-1" of GTP has been measured in D2O at 25 degrees C under several degrees of protonation in the pD range 1.2-8.4.	Hydrogen	60-69	relaxin 2	Homo sapiens	70-78
2163125-4	1990	Diastereoisomers of 17-tetrahydropyranyl ether derivatives were recognized from characteristic modifications of 1H NMR signals of H-2", H-6", H-1, H-17, and 18-CH3 protons as well as from the 13C NMR doublet signals corresponding to C-2", C-4", C-6", C-12, C-13, C-16, and C-17 carbon atoms.	Hydrogen	112-114	homeobox C13	Homo sapiens	257-261
22072785-5	2012	However, favorable interactions beyond the sialic acid are found only for alpha2-6-linked glycans and are mediated by Asp190 and Asp225, which hydrogen bond with Gal-2 and GlcNAc-3.	Hydrogen	143-151	immunoglobulin binding protein 1	Homo sapiens	74-82
2191717-0	1990	NMR study of the phosphoryl binding loop in purine nucleotide proteins: evidence for strong hydrogen bonding in human N-ras p21.	Hydrogen	92-100	NRAS proto-oncogene, GTPase	Homo sapiens	118-123
22072785-5	2012	However, favorable interactions beyond the sialic acid are found only for alpha2-6-linked glycans and are mediated by Asp190 and Asp225, which hydrogen bond with Gal-2 and GlcNAc-3.	Hydrogen	143-151	galectin 2	Homo sapiens	162-167
2331513-8	1990	These values show that the Boc group has a trans-trans conformation while the peptide backbone adopts a beta-turn II conformation, which is stabilized by an intramolecular hydrogen bond of length of 3.05(1) A.	Hydrogen	172-180	BOC cell adhesion associated, oncogene regulated	Homo sapiens	27-30
2331517-2	1990	The substructural units, 5-14 linear and 5-14 cyclic, have been used as models for MCH-- H-Asp1-Thr-Met-Arg-Cys-Met-Val-Gly-Arg HO-Val17-Glu-Trp-Cys-Pro-Arg-Tyr-Val in 1H-nmr conformational studies.	Hydrogen	168-170	beta-secretase 2	Homo sapiens	91-95
22916091-6	2012	Molecular docking studies predicted that compound 8 binds at the heparin binding domain of VEGF through strong hydrogen bonding with Lys-30 and Gln-20 amino acid residues, and consistent with the prediction, compound 8 inhibited binding of VEGF to immobilized heparin.	Hydrogen	111-119	vascular endothelial growth factor A	Mus musculus	91-95
33777703-10	2021	The compounds also exhibited high binding affinities and molecular interactions with the active site amino acid residues of Drosophila GST and the inhibitor binding site of Drosophila AChE in an in silico molecular docking analysis, with BPDE forming stable hydrogen bonds with AChE.	Hydrogen	258-266	Glutathione S transferase S1	Drosophila melanogaster	135-138
22916091-6	2012	Molecular docking studies predicted that compound 8 binds at the heparin binding domain of VEGF through strong hydrogen bonding with Lys-30 and Gln-20 amino acid residues, and consistent with the prediction, compound 8 inhibited binding of VEGF to immobilized heparin.	Hydrogen	111-119	vascular endothelial growth factor A	Mus musculus	240-244
33803465-0	2021	Regulation of K+ Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels.	Hydrogen	34-42	potassium voltage-gated channel subfamily B member 1	Homo sapiens	51-56
21964458-12	2012	The structure of ReP1-NCXSQ predicted from the amino acid sequence has been confirmed by X-ray crystal analysis; it has a "barrel" formed by ten beta sheets and two alpha helices, with a lipid coordinated by hydrogen bonds with Arg 126 and Tyr 128.	Hydrogen	208-216	CHM Rab escort protein	Homo sapiens	17-21
33803465-0	2021	Regulation of K+ Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels.	Hydrogen	34-42	potassium voltage-gated channel subfamily B member 2	Homo sapiens	58-63
22180888-1	2011	We applied infrared matrix isolation spectroscopy to investigate the reactions between Cl atom and acetylene (C2H2) in a para-hydrogen (p-H2) matrix at 3.2 K; Cl was produced via photodissociation at 365 nm of matrix-isolated Cl2 in situ.	Hydrogen	126-134	polyhomeotic homolog 2	Homo sapiens	136-140
33777333-7	2021	By further analysis of the extensive hydrogen-bonding networks, residues D405, K417, Y421, Y453, L455, R457, Y473, A475, N487, G502, Y505 of RBD, which mainly interacted with CDR H3/L3 and two conserved motifs SNY, SGGS, were identified as key epitopes.	Hydrogen	37-45	cdr h3/l3	None	175-184
22220043-2	2011	In the crystal, C-H O hydrogen bonds link the mol-ecules to form C(11) chains propagating in [010].	Hydrogen	22-30	RNA polymerase III subunit K	Homo sapiens	65-70
21852690-5	2011	COX-1 and MnLOX abstracted hydrogen at C-11 of (12Z)-18:1 and C-12 of (13Z)-18:1.	Hydrogen	27-35	RNA polymerase III subunit K	Homo sapiens	39-43
28364102-0	2017	[Value of 1H-MRS on SCA3/MJD diagnosis and clinical course].	Hydrogen	10-12	ataxin 3	Homo sapiens	20-24
28364102-1	2017	OBJECTIVE: To investigate the value of proton magnetic resonance spectroscopy (1H-MRS) on the diagnosis of SCA3/MJD, and to calculate the correlation between 1H-MRS ratio and the clinical score.	Hydrogen	79-81	ataxin 3	Homo sapiens	107-111
28364102-2	2017	:  Methods: Sixteen patients with SCA3/MJD and 19 healthy volunteers were scanned with 1H-MRS.	Hydrogen	87-89	ataxin 3	Homo sapiens	34-38
28364102-11	2017	1H-MRS is useful in the diagnosis of SCA3/MJD.	Hydrogen	0-2	ataxin 3	Homo sapiens	37-41
21852690-6	2011	(11Z)-18:1 was subject to hydrogen abstraction at C-10 by MnLOX and at both allylic positions by COX-1.	Hydrogen	26-34	chromosome 12 open reading frame 57	Homo sapiens	50-54
21852690-9	2011	We conclude that COX-1 and MnLOX can readily abstract allylic hydrogens of octadecenoic fatty acids from C-10 to C-12 and 8R-DOX from C-7 and C-12.	Hydrogen	62-71	chromosome 12 open reading frame 57	Homo sapiens	105-109
21458445-4	2011	Intraperitoneal applications of CXCR2 antagonist SB225002 or SB332235 were administered 1h prior and 1h after oropharyngeal aspiration.	Hydrogen	88-90	chemokine (C-X-C motif) receptor 2	Mus musculus	32-37
34890995-5	2022	Among these quinolin-2(1H)-one derivatives, compound 7a allowed 16.7% of V30M-TTR (3.6 muM) fibril formation at the same concentration and 49.6% at a concentration of 1.8 muM.	Hydrogen	23-25	transthyretin	Homo sapiens	78-81
34954830-4	2022	Results showed that zein exhibited a strong binding affinity for C3G via van der Waals forces and hydrogen bonds determined in fluorescence assays.	Hydrogen	98-106	Rap guanine nucleotide exchange factor 1	Homo sapiens	65-68
21877721-8	2011	Finally, our work shows that the natural base adenine (A) is further inserted into the AAG active site than the damaged substrates, which results in the loss of a hydrogen bond with Y127 and misaligns the general base (E125) and water nucleophile to lead to poor nucleophile activation.	Hydrogen	163-171	N-methylpurine DNA glycosylase	Homo sapiens	87-90
34635265-4	2022	The domoic acid molecule could be recognized in imprinted cavities of PAM reversibly through hydrogen bonding.	Hydrogen	93-101	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	70-73
21984209-5	2011	The C-terminal domain of DKK1 (DKK1c) interacts with the top surface of the LRP6-E3 YWTD propeller and given their structural similarity, probably also that of the LRP6-E1 propeller, through conserved hydrophobic patches buttressed by a network of salt bridges and hydrogen bonds.	Hydrogen	265-273	LDL receptor related protein 6	Homo sapiens	76-80
34907481-5	2021	In addition, the high-affinity PDE9A inhibitors always interact with the conservative hydrophobic pocket as well as Tyr424 and Ala452 of PDE9A, while PDE10A selective inhibitors need to have two hydrophobic groups and two hydrogen bond donors to interact with the conservative Tyr693, Gln726, and Phe729 of PDE10A.	Hydrogen	222-230	phosphodiesterase 9A	Homo sapiens	31-36
21843961-7	2011	Dependence of T(1) on nitrogen nuclear spin state m(I) was observed for both (14)N and (15)N. Unresolved hydrogen/deuterium hyperfine couplings dominate overall line widths.	Hydrogen	105-113	spindlin 1	Homo sapiens	39-43
34851341-8	2021	Molecular docking showed that the majority binding energy of peptides-targets was between -10.35 kcal mol-1 and -18.72 kcal mol-1, and peptides mainly interacted with the core targets (Btk, Gstm1, and Rac1) by hydrogen-bonding interactions.	Hydrogen	210-218	Rac family small GTPase 1	Homo sapiens	201-205
34879065-5	2021	The structure of the AUP1 G2BR (G2BRAUP1) in complex with UBE2G2 reveals an interface that includes a network of salt bridges, hydrogen bonds, and hydrophobic interactions essential for AUP1 function in cells.	Hydrogen	127-135	ubiquitin conjugating enzyme E2 G2	Homo sapiens	58-64
34752079-0	2021	A Simple Molten Salt Route to Crystalline beta-MoB2 Nanosheets with High Activity for the Hydrogen Evolution Reaction.	Hydrogen	90-98	MOB kinase activator 2	Homo sapiens	47-51
21922564-7	2011	Evidently, intramolecular hydrogen-bonding interactions between axial chloride and methyl groups stabilize syn conformations.	Hydrogen	26-34	synemin	Homo sapiens	107-110
34619494-9	2021	In silico docking simulation revealed that SHQA established specific interactions with the key amino acid residues of PI3K, Akt, and Nrf2-Keap1 via hydrogen bonding and van der Waals interactions, which may affect the biological capacities of target markers.	Hydrogen	148-156	Kelch-like ECH-associated protein 1	Rattus norvegicus	138-143
21820903-0	2011	CH/pi hydrogen bonds play a role in ligand recognition and equilibrium between active and inactive states of the beta2 adrenergic receptor: an ab initio fragment molecular orbital (FMO) study.	Hydrogen	6-14	adrenoceptor beta 2	Homo sapiens	113-138
34601763-5	2021	Hydrogen-deuterium exchange by mass spectrometry, as well as molecular dynamics simulations, reveal that the dynamics of the tSH2 modules of Syk and ZAP-70 differ, with most of these differences occurring in the C-terminal SH2 domain.	Hydrogen	0-8	spleen associated tyrosine kinase	Homo sapiens	141-144
34601763-5	2021	Hydrogen-deuterium exchange by mass spectrometry, as well as molecular dynamics simulations, reveal that the dynamics of the tSH2 modules of Syk and ZAP-70 differ, with most of these differences occurring in the C-terminal SH2 domain.	Hydrogen	0-8	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	149-155
21667022-6	2011	Computational modeling showed that LJJ-10 is bound into the IGF-1R via hydrophobic interactions with Leu975, Val983, Ala1001, Glu1050 and Met1052 with one hydrogen bond between 6-F and Met1052.	Hydrogen	155-163	insulin like growth factor 1 receptor	Homo sapiens	60-66
34881291-0	2021	The Hydrogen-Coupled Oligopeptide Membrane Cotransporter Pept2 is SUMOylated in Kidney Distal Convoluted Tubule Cells.	Hydrogen	4-12	solute carrier family 15 (H+/peptide transporter), member 2	Mus musculus	57-62
34881291-5	2021	SUMOylation of the renal hydrogen-coupled oligopeptide and drug co-transporter (Pept2) at one site (K139) was found to be highly regulated by aldosterone.	Hydrogen	25-33	solute carrier family 15 (H+/peptide transporter), member 2	Mus musculus	80-85
34802532-7	2021	Molecular docking results indicated that ASN511 at the cox1 subunit was the binding site of AITC by one hydrogen bond, with a bond distance of 2.1 A.	Hydrogen	104-112	COX1	Sitophilus zeamais	55-59
21638318-12	2011	Immunocytochemistry following alpha(2)delta(1) knockdown showed decreased membrane localization of Ca(v) 3.2 (alpha(1H)) at the plasma membrane, suggesting that the diminished ATP release and ERK1/2 activation in response to membrane stretch resulted from a lack of Ca(v) 3.2 (alpha(1H)) at the cell membrane.	Hydrogen	116-118	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	99-108
21638318-12	2011	Immunocytochemistry following alpha(2)delta(1) knockdown showed decreased membrane localization of Ca(v) 3.2 (alpha(1H)) at the plasma membrane, suggesting that the diminished ATP release and ERK1/2 activation in response to membrane stretch resulted from a lack of Ca(v) 3.2 (alpha(1H)) at the cell membrane.	Hydrogen	283-285	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	99-108
21724434-3	2011	MD trajectories simulated in different unfolding conditions suggest that urea destabilizes BLG structure weakening protein::protein hydrophobic interactions and the hydrogen bond network.	Hydrogen	165-173	beta-lactoglobulin	Bos taurus	91-94
34642712-2	2021	In this work, we propose a spin caloritronic device constructed on hydrogen-terminated sawtooth graphene-like nanoribbons periodically embedded with four- and eight-membered rings to investigate the thermal spin currents and thermoelectric properties by using density functional theory combined with the non-equilibrium Green"s function method.	Hydrogen	67-75	spindlin 1	Homo sapiens	27-31
21697086-2	2011	beta1,3-Glucans form a triple-helical structure stabilized by interchain hydrogen bonds.	Hydrogen	73-81	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	0-7
34623157-6	2021	This proton transfer (PT) reaction within a hydrogen (H)-bonded complex was found to be barrierless and very rapid, with key reaction coordinates comprising the proton coordinate, the H-bond separation RON, and a solvent coordinate, reflecting the water solvent rearrangement involved in the neutral to ion pair conversion.	Hydrogen	44-52	macrophage stimulating 1 receptor	Homo sapiens	202-205
21741637-8	2011	In cells exposed for 10min, 1h and 3h to different amounts of PM(10), transcription of TNFalpha and TRAP1, which code for a key pro-inflammatory cytokine and a mitochondrial protein involved in cell protection from oxidative stress, respectively, was shown to be modulated in a time-dependent, but not a dose-dependent manner.	Hydrogen	28-30	TNF receptor associated protein 1	Homo sapiens	100-105
34698206-9	2021	The ternary composite aerogel has advantages of excellent mechanical properties, a low thermal conductivity and an improved thermal stability, because strong hydrogen bonds form between the PVA, GA and CNF.	Hydrogen	158-166	NPHS1 adhesion molecule, nephrin	Homo sapiens	202-205
34605656-9	2021	A strong positive correlation has been observed between the red shift of the OH groups in MSA and H2SO4 and the corresponding O-H elongation as a result of hydrogen bond formation.	Hydrogen	156-164	thyroid peroxidase	Homo sapiens	90-93
34605656-10	2021	Topological analysis employing QTAIM shows that most of the charge density and the Laplacian values at bond critical points (BCPs) of the hydrogen bonds of the MSA   (H2SO4)n (n = 1-3) complexes fall within the standard hydrogen-bond criteria.	Hydrogen	138-146	thyroid peroxidase	Homo sapiens	160-163
21650454-6	2011	It is shown that the calculated frequency shifts and general conclusions of the original work are sound but that the coherent vibrational frequency shifts of the C(10), C(11), and C(12) hydrogen-out-of-plane vibrations occur with a 140 fs time constant rather than the previously reported 325 fs time constant.	Hydrogen	186-194	chromosome 12 open reading frame 57	Homo sapiens	162-167
34605656-10	2021	Topological analysis employing QTAIM shows that most of the charge density and the Laplacian values at bond critical points (BCPs) of the hydrogen bonds of the MSA   (H2SO4)n (n = 1-3) complexes fall within the standard hydrogen-bond criteria.	Hydrogen	220-228	thyroid peroxidase	Homo sapiens	160-163
34605656-13	2021	Proportionately, a larger number of hydrogen bonds in ternary MSA   (H2SO4)2 demonstrate a partial covalent character when compared with the quaternary clusters.	Hydrogen	36-44	thyroid peroxidase	Homo sapiens	62-65
34091333-6	2021	Results show that LBP/PVP-ZIF-67 exhibits excellent photothermal performance, and higher potential in electrochemical hydrogen evolution than bare LBP or LBP/PVP.	Hydrogen	118-126	lipopolysaccharide binding protein	Homo sapiens	18-32
21687896-6	2011	The position of the substituents plays also an important role and carbonyl oxides having a hydrogen atom substituent in syn react faster than carbonyl oxides having a hydrogen atom substituent in anti.	Hydrogen	91-99	synemin	Homo sapiens	120-123
34619770-8	2022	Hydrogen-deuterium exchange mass spectrometryshowed that p.Arg127Gln of LRR, while having little effect on the dynamics of the LRR locally, enhances the conformational dynamics of the GPIbalpha C-terminal disulfide loop structure.	Hydrogen	0-8	glycoprotein Ib platelet subunit alpha	Homo sapiens	184-193
34524798-5	2021	Then, the chain propagates via a general C CHR + CH2 coupling and subsequent hydrogen-assisted isomerization of the resulting allene ligand mu-eta1:eta3-H2C C CHR to a higher vinylidene homologue mu-eta1:eta1-C CH(CH2)R. By repeating this reaction sequence, up to C6 chains have been synthesized in a stepwise fashion.	Hydrogen	77-85	chromate resistance; sulfate transport	Homo sapiens	159-162
21687896-6	2011	The position of the substituents plays also an important role and carbonyl oxides having a hydrogen atom substituent in syn react faster than carbonyl oxides having a hydrogen atom substituent in anti.	Hydrogen	167-175	synemin	Homo sapiens	120-123
34641573-3	2021	Besides that, PtC3+ could abstract a hydrogen atom from CH4 to generate PtC3H+/CH3, while IrC3+ could not.	Hydrogen	37-45	nuclear receptor coactivator 4	Homo sapiens	14-18
21691635-2	2011	Standard quantum chemical calculations (B3LYP/D95+(d,p)) predict a low barrier hydrogen bond (LBHB) and thereby a delocalized proton in the NHN(+) hydrogen bridge.	Hydrogen	79-87	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	42-45
21691635-2	2011	Standard quantum chemical calculations (B3LYP/D95+(d,p)) predict a low barrier hydrogen bond (LBHB) and thereby a delocalized proton in the NHN(+) hydrogen bridge.	Hydrogen	147-155	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	42-45
34453696-0	2021	1H, 13C and 15N assignment of stem-loop SL1 from the 5"-UTR of SARS-CoV-2.	Hydrogen	0-2	TATA-box binding protein associated factor, RNA polymerase I subunit A	Homo sapiens	40-43
21777816-3	2011	This conclusion is based on binding studies and cocrystal structures of PHD(UHRF1) bound to histone H3 peptides, where the guanidinium group of unmodified R2 forms an extensive intermolecular hydrogen bond network, with methylation of H3R2, but not H3K4 or H3K9, disrupting complex formation.	Hydrogen	192-200	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	76-81
21253892-6	2011	The peptide/MHC/TCR interface was found to hold significant number of solvent molecules, more specifically the peptide has been found to have approximately seventeen hydrogen bonds with water molecules.	Hydrogen	166-174	major histocompatibility complex, class I, C	Homo sapiens	12-15
34390190-6	2021	Then the electrolyzer apparatus assembled with Ru-CoOx /NF, just requires the ultra-low voltage of 2.2 and 2.62 V to support the current density of 1000 mA cm-2 in alkaline water and seawater electrolysis, respectively, for hydrogen production, better than that of the commercial Pt/C and RuO2 catalysts.	Hydrogen	224-232	neurofascin	Homo sapiens	56-58
21525337-5	2011	The primary GII norovirus-HBGA interaction involved six hydrogen bonds between a terminal alphafucose1-2 of the HBGAs and a dimeric capsid interface, which was composed of elements from two protruding subdomains.	Hydrogen	56-64	hemoglobin subunit gamma 1	Homo sapiens	26-30
34638995-6	2021	Computational structural modeling predicts that substitution of a threonine for an alanine p.(Ala785Thr) results in the formation of three new hydrogen bonds with the neighboring residues, which causes misfolding of EPHA2 in both scenarios.	Hydrogen	143-151	EPH receptor A2	Homo sapiens	216-221
21514360-7	2011	The immunoreactivity of p-MARCKS(S152/156) was higher in the CsA group 1h after injection, whereas p-GAP43(S41) immunoreactivity was increased by CsA after 5h.	Hydrogen	71-73	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	26-32
34288552-5	2021	Meanwhile, X-ray photoelectron spectroscopy (XPS) and hydrogen temperature-programmed reduction (H 2 -TPR) results reveal that an even stronger electron donation from the reduced support to Ru nanoparticles is achieved.	Hydrogen	54-62	translocated promoter region, nuclear basket protein	Homo sapiens	102-105
34310047-11	2021	Additionally, the hydrogen production rate increases linearly with the ADH dosage, the hydrogen production rate reaches 578 mmol h -1 mol -1 Ru when the ADH dosage is 180 unit at 35 C.	Hydrogen	18-26	aldo-keto reductase family 1 member A1	Homo sapiens	71-74
34310047-11	2021	Additionally, the hydrogen production rate increases linearly with the ADH dosage, the hydrogen production rate reaches 578 mmol h -1 mol -1 Ru when the ADH dosage is 180 unit at 35 C.	Hydrogen	18-26	aldo-keto reductase family 1 member A1	Homo sapiens	153-156
21770539-2	2011	Cmc2(1)-NaH(9) containing both H(2) and H(-) units is metallic at P&gt;250  GPa.	Hydrogen	31-35	C-X9-C motif containing 2	Homo sapiens	0-4
34310047-11	2021	Additionally, the hydrogen production rate increases linearly with the ADH dosage, the hydrogen production rate reaches 578 mmol h -1 mol -1 Ru when the ADH dosage is 180 unit at 35 C.	Hydrogen	87-95	aldo-keto reductase family 1 member A1	Homo sapiens	71-74
34310047-11	2021	Additionally, the hydrogen production rate increases linearly with the ADH dosage, the hydrogen production rate reaches 578 mmol h -1 mol -1 Ru when the ADH dosage is 180 unit at 35 C.	Hydrogen	87-95	aldo-keto reductase family 1 member A1	Homo sapiens	153-156
34577377-1	2021	Highly accurate, quantitative analyses of mixtures of hydrogen isotopologues-both the stable species, H2, D2, and HD, and the radioactive species, T2, HT, and DT-are of great importance in fields as diverse as deuterium-tritium fusion, neutrino mass measurements using tritium beta-decay, or for photonuclear experiments in which hydrogen-deuterium targets are used.	Hydrogen	54-62	relaxin 2	Homo sapiens	102-108
21545128-7	2011	The N1 atom of pteridine ring of Trm forms hydrogen bonding with backbone amide proton of R13, and the phenyl ring took part in a hydrophobic interaction with the aromatic ring of F18.	Hydrogen	43-51	mastermind like domain containing 1	Homo sapiens	180-183
34514271-4	2021	The transition from inactive to an active state for the S-protein of SARS-CoV-2 is more cooperative, involving simultaneous disruptions of several key interfacial hydrogen bonds, and the transition encounters a much higher free energy barrier.	Hydrogen	163-171	vitronectin	Homo sapiens	56-65
21754762-3	2011	The conformation of the imine bond [1.2888 (18) A] is E. The syn arrangement of the thione S and amino H atoms enables the formation of N-H S hydrogen bonds between centrosymmetrically related mol-ecules.	Hydrogen	142-150	synemin	Homo sapiens	61-64
34406748-4	2021	We identified the system propargyl alcohol + pH2   allyl alcohol to yield 1H polarization in excess of P   13% by using only 50% enriched pH2 at a pressure of  1 bar.	Hydrogen	74-76	polyhomeotic homolog 2	Homo sapiens	45-48
34406748-4	2021	We identified the system propargyl alcohol + pH2   allyl alcohol to yield 1H polarization in excess of P   13% by using only 50% enriched pH2 at a pressure of  1 bar.	Hydrogen	74-76	polyhomeotic homolog 2	Homo sapiens	138-141
21465017-1	2011	Chirality of a nucleotide-Cu(II) complex molecule, [CuNa(GMP)(HGMP)(H(2)O)(7)] 6(H(2)O) CH(3)OH (GMP = guanosine 5"-monophosphate), is delivered to the three-dimensional supramolecular architecture by hydrogen bonding.	Hydrogen	201-209	5'-nucleotidase, cytosolic II	Homo sapiens	57-60
34212514-6	2021	The docking results demonstrated that hydrogen bonds and Van der Waals force were the main forces to drive the binding of the four compounds to beta2-adrenoceptor.	Hydrogen	38-46	adrenoceptor beta 2	Homo sapiens	144-162
21734907-5	2011	In the absence of sulfate, many SRB ferment organic acids and alcohols, producing hydrogen, acetate, and carbon dioxide, and may even rely on hydrogen- and acetate-scavenging methanogens to convert organic compounds to methane.	Hydrogen	82-90	chaperonin containing TCP1 subunit 4	Homo sapiens	32-35
34471125-5	2021	Using hydrogen-deuterium exchange and molecular dynamics simulations we show that CD47"s ECLR architecture, comprised of two extracellular loops and the SWF loop, creates a molecular environment stabilizing the ECD for presentation on the cell surface.	Hydrogen	6-14	CD47 molecule	Homo sapiens	82-86
21734907-5	2011	In the absence of sulfate, many SRB ferment organic acids and alcohols, producing hydrogen, acetate, and carbon dioxide, and may even rely on hydrogen- and acetate-scavenging methanogens to convert organic compounds to methane.	Hydrogen	142-150	chaperonin containing TCP1 subunit 4	Homo sapiens	32-35
34363306-1	2021	A series of Ru-based catalysts have been developed for the hydrogen evolution reaction (HER) by the facile impregnation of copious and eco-friendly bacterial cellulose (BC) with Ru(bpy)3 Cl2 (bpy = 2,2"-bipyridine) followed by pyrolysis.	Hydrogen	59-67	endogenous retrovirus group W member 5	Homo sapiens	187-190
21425467-3	2011	A nonlinear, temperature-responsive PEG(Alk) is synthesized, and is then used to form hydrogen-bonded multilayers with poly(methacrylic acid) (PMA) at pH 5.	Hydrogen	86-94	ALK receptor tyrosine kinase	Homo sapiens	40-43
21425467-6	2011	At pH 7, by disrupting the hydrogen bonding between the polymers, PEG(Alk) LbL films and PEG(Alk) -based capsules are obtained.	Hydrogen	27-35	ALK receptor tyrosine kinase	Homo sapiens	70-73
21416510-3	2011	For the trisubstituted triazatrinaphthylenes (TrisK), the length of the substituents and the presence of terminal hydrogen-bond-donor groups (NH(2)) were shown to be crucial for ensuring a high quadruplex affinity (DeltaT(1/2) values of up to 20  C at 1 muM for the best candidate, TrisK3-NH) and selectivity versus duplex DNA.	Hydrogen	114-122	triadin	Homo sapiens	46-51
34341808-0	2021	Spin transition triggered by desorption of crystal solvents for a two-dimensional cobalt(II) complex with hydrogen bonding.	Hydrogen	106-114	spindlin 1	Homo sapiens	0-4
21499855-8	2011	Preliminary molecular docking studies suggest that bile acids interact with amino acids at the active site of the PLA(2) through different interactions, CA showed hydrogen bonds with His48, whereas, UDCA displayed with Asp49.	Hydrogen	163-171	phospholipase A2 group IIA	Homo sapiens	114-120
34443575-0	2021	Modeling of the Response of Hydrogen Bond Properties on an External Electric Field: Geometry, NMR Chemical Shift, Spin-Spin Scalar Coupling.	Hydrogen	28-36	spindlin 1	Homo sapiens	114-118
34443575-0	2021	Modeling of the Response of Hydrogen Bond Properties on an External Electric Field: Geometry, NMR Chemical Shift, Spin-Spin Scalar Coupling.	Hydrogen	28-36	spindlin 1	Homo sapiens	119-123
34360580-6	2021	AvnC was predicted to interact with tyrosinase through two hydrogen bonds at Ser360 (distance: 2.7 A) and Asn364 (distance: 2.6 A).	Hydrogen	59-67	tyrosinase	Homo sapiens	36-46
34105527-3	2021	Under the synergistic effect of hydrogen bonding and electrostatic adsorption, Fe3O4@PANI can rapidly and easily enrich N-glycopeptides derived from standard protein (bovine fetuin and transferrin) tryptic digests and serum haptoglobin tryptic digests.	Hydrogen	32-40	haptoglobin	Bos taurus	224-235
34322022-13	2021	CC docking studies in iNOS and eNOS active site revealed hydrogen bonding of the hydroxylated chain with residues Glu377 and Glu361, involved in the substrate recognition, and explains its higher binding affinity than CA.	Hydrogen	57-65	nitric oxide synthase 3	Rattus norvegicus	31-35
34109953-4	2021	Co-N-Ni3S2/NF exhibits excellent oxygen evolution reaction activity (an overpotential of 285 mV@50 mA cm-2) and hydrogen evolution reaction activity (an overpotential of 215 mV@10 mA cm-2) in 1 M KOH solution.	Hydrogen	112-120	neurofascin	Homo sapiens	5-13
34086015-5	2021	And during our test, the averaged prediction error of 1H NMR chemical shifts is as small as 0.32 ppm, and the error of C-H BDE estimation is 2.7 kcal mol-1.	Hydrogen	54-56	homeobox D13	Homo sapiens	123-126
34151116-5	2021	Herein, we examine the hydrogen bonding between MATE1 and one or more metformin molecules.	Hydrogen	23-31	solute carrier family 47 member 1	Homo sapiens	48-53
34151116-6	2021	The simulation results indicate that metformin continuously forms and breaks off hydrogen bonds with MATE1 residues.	Hydrogen	81-89	solute carrier family 47 member 1	Homo sapiens	101-106
34470955-7	2021	The results suggest that the ability to form hydrogen bonds at the azole moiety is strongly involved in the hMATE1 inhibition.	Hydrogen	45-53	solute carrier family 47 member 1	Homo sapiens	108-114
35489259-5	2022	Hydrophobic interactions were dominant in the non-covalent interactions between (E)-2-octenal/(Z)-2-penten-1-ol and pea protein, whereas hydrogen bonding was dominant in the non-covalent interactions between hexanal and pea protein.	Hydrogen	137-145	cystatin 12, pseudogene	Homo sapiens	80-85
35063851-3	2022	Hydrogen bond, electrostatic interaction and hydrophobic interaction were involved in the formation of Gli-ChS NPs.	Hydrogen	0-8	GLI family zinc finger 1	Homo sapiens	103-106
35334135-1	2022	Employing pure water, the ultimate green source of hydrogen donor to initiate chemical reactions that involve a hydrogen atom transfer (HAT) step is fascinating but challenging due to its large H-O bond dissociation energy (BDE H-O = 5.1 eV).	Hydrogen	51-59	homeobox D13	Homo sapiens	224-227
35334135-1	2022	Employing pure water, the ultimate green source of hydrogen donor to initiate chemical reactions that involve a hydrogen atom transfer (HAT) step is fascinating but challenging due to its large H-O bond dissociation energy (BDE H-O = 5.1 eV).	Hydrogen	112-120	homeobox D13	Homo sapiens	224-227
35544990-4	2022	Thus, this study aimed to explore the association of the CACNA1C genotype with ACC glutamatergic metabolites measured by 1H-MRS in both BD and HC subjects.	Hydrogen	121-123	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	57-64
35487380-5	2022	The incorporated PAM segments can form additional network structure via hydrogen bonding, resulting in enhanced tensile strength but decreased extensibility when more PAM segments are introduced.	Hydrogen	72-80	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	17-20
35603815-4	2022	Hydrogen bonds played the most important roles in impacting the structure stabilities of the peptide-tyrosinase complexes.	Hydrogen	0-8	tyrosinase	Homo sapiens	101-111
35628622-6	2022	Through the MD simulation, we further confirmed that the RBD-1CM1 aptamer can form the most stable complex with the S protein based on the number of hydrogen bonds formed between the two biomolecules.	Hydrogen	149-157	vitronectin	Homo sapiens	116-125
35590444-7	2022	These results indicate the promising application potential of FeCoNiS x /NF electrode for hydrogen generation.	Hydrogen	90-98	neurofascin	Homo sapiens	73-75
35545728-10	2022	Molecular docking and MD simulations revealed that the hydrophobic and hydrogen bond interactions are dominant in the PEBP1"s pocket.	Hydrogen	71-79	phosphatidylethanolamine binding protein 1	Homo sapiens	118-123
35341785-9	2022	In conclusion, the present study revealed a protective effect of hydrogen on levothyroxine -induced cardiac hypertrophy by regulating angiotensin II type 1 receptors and NOX2-mediated oxidative stress in rats.	Hydrogen	65-73	cytochrome b-245 beta chain	Rattus norvegicus	170-174
35344901-5	2022	The AI-predicted protein structure of human TMEM16F protein was applied for molecular docking, revealing that 4"-NO2 of 5 formed hydrogen bonding with Arg809, which was blocked by 2"-Cl in the case of niclosamide.	Hydrogen	129-137	anoctamin 6	Homo sapiens	44-51
21323310-8	2011	This arises because the pK(a) of the second Cys ligand in the CXXC motif of HAH1 is 1.5 pH units lower due to stabilization of the thiolate via a hydrogen-bonding interaction with the side chain of Lys60.	Hydrogen	146-154	antioxidant 1 copper chaperone	Homo sapiens	76-80
21595200-1	2011	Using the CARS (coherent anti-Stokes Raman spectroscopy) detection technique, the authors investigated the electronic-to-rovibrational levels energy transfer between electronically excited Rb2 and H2.	Hydrogen	197-199	RB transcriptional corepressor like 2	Homo sapiens	189-192
20926394-5	2011	We then solved the complex structure of the hTra2-beta RRM with the (GAA)(2) sequence, and found that the AGAA tetra-nucleotide was specifically recognized through hydrogen-bond formation with several amino acids on the N- and C-terminal extensions, as well as stacking interactions mediated by the unusually aligned aromatic rings on the beta-sheet surface.	Hydrogen	164-172	transformer 2 beta homolog	Homo sapiens	44-54
21126103-2	2011	Poly(L-glutamic acid) modified with alkyne moieties (PGA(Alk)) was alternately assembled with poly(N-vinyl pyrrolidone) (PVPON) on silica particles via hydrogen-bonding.	Hydrogen	152-160	ALK receptor tyrosine kinase	Homo sapiens	57-60
21320803-5	2011	The complex conformations of the new designed inhibitor and two isozymes designate the formation of the hydrogen bond between the newly added group (hydroxypropyl group) and Q64 of hCA VII but N67 of hCA II.	Hydrogen	104-112	carbonic anhydrase 2	Homo sapiens	200-206
21072508-6	2011	The hydrogen bonds between digoxigenin and DigA16 cause the rupture forces on ligand removal in DigA16 and RBP to differ.	Hydrogen	4-12	retinol binding protein 4	Homo sapiens	107-110
20623648-2	2011	The difference in intramolecular hydrogen bond (IMHB) strength clearly reflects the inequivalence of substitution pairs where the calculated IMHB strength is found to be greater for HN12 and HN21 than HN23.	Hydrogen	33-41	MT-RNR2 like 12 (pseudogene)	Homo sapiens	182-186
21040763-5	2011	In the present study, the pretreatment of Al(malt)3 at nonlethal level (200 muM, 24 h) significantly reduced BDNF (10 ng/ml, 1h)-induced Arc expression in SH-SY5Y human neuroblastoma cells.	Hydrogen	125-127	brain derived neurotrophic factor	Homo sapiens	109-113
21117672-1	2011	Hydrogen exchange mass spectrometry (HXMS) coupled to proteolytic digestion has been used to probe the conformation of bovine beta-lactoglobulin (BLG), bovine alpha-lactalbumin (BLA), and human serum albumin (HSA) in solution and while adsorbed to the hydrophobic interaction chromatography media Phenyl Sepharose 6FF.	Hydrogen	0-8	beta-lactoglobulin	Bos taurus	126-144
21117672-1	2011	Hydrogen exchange mass spectrometry (HXMS) coupled to proteolytic digestion has been used to probe the conformation of bovine beta-lactoglobulin (BLG), bovine alpha-lactalbumin (BLA), and human serum albumin (HSA) in solution and while adsorbed to the hydrophobic interaction chromatography media Phenyl Sepharose 6FF.	Hydrogen	0-8	beta-lactoglobulin	Bos taurus	146-149
21117672-4	2011	The hydrogen-deuterium exchange patterns of BLG and BLA on the surface suggest a structure that resembles each protein"s respective solution phase molten globule state.	Hydrogen	4-12	beta-lactoglobulin	Bos taurus	44-47
21117672-6	2011	COREX, an algorithm used to compute protein folding stabilities, correctly predicts solution hydrogen-deuterium exchange patterns for BLG and offers insight into its adsorbed phase stabilities but is unreliable for BLA predictions.	Hydrogen	93-101	beta-lactoglobulin	Bos taurus	134-137
21210971-10	2010	The MD of apo catB at pH 5.5 was very stable, and presented the highest number and occupancy of hydrogen bonds within the inter-domain interface.	Hydrogen	96-104	cathepsin B	Homo sapiens	14-18
20702073-8	2010	The value of lnk elevates with the increase in mobile phase NaCl concentration i.e. Deltalnk/Deltac(NaCl) depends on the number of water molecules not stabilised by hydrogen bonds in bile acid hydration sheath.	Hydrogen	165-173	SH2B adaptor protein 3	Homo sapiens	13-16
20821791-0	2010	High specificity in protein recognition by hydrogen-bond-surrogate alpha-helices: selective inhibition of the p53/MDM2 complex.	Hydrogen	43-51	MDM2 proto-oncogene	Homo sapiens	114-118
20853889-1	2010	Bulky DNA addition products (adducts) formed through attack at the C8 site of guanine can adopt the syn orientation about the glycosidic bond due to changes in conformational stability or hydrogen-bonding preferences directly arising from the bulky group.	Hydrogen	188-196	synemin	Homo sapiens	100-103
20601226-10	2010	The 3D model of the catalytic domain of rat DPP III showed that the carboxyl oxygen atoms of Glu507 and Glu512 form the hydrogen bonds to the nitrogen atoms of His455 and His450.	Hydrogen	120-128	dipeptidylpeptidase 3	Rattus norvegicus	44-51
20563762-0	2010	Sequence-specific 1H, 13C, and 15N assignment of the extended PDZ3 domain of the protein tyrosine phosphatase basophil-like PTP-BL.	Hydrogen	18-20	protein tyrosine phosphatase non-receptor type 13	Homo sapiens	81-123
20563762-0	2010	Sequence-specific 1H, 13C, and 15N assignment of the extended PDZ3 domain of the protein tyrosine phosphatase basophil-like PTP-BL.	Hydrogen	18-20	protein tyrosine phosphatase non-receptor type 13	Homo sapiens	124-130
20563763-0	2010	1H, 15N and 13C assignments of an intramolecular Lmo2-LIM2/Ldb1-LID complex.	Hydrogen	0-2	LIM domain only 2	Homo sapiens	49-53
20670624-8	2010	Ipsilateral CA3(b) neuronal loss, but not cortical tissue loss, was significantly reduced 1 month post-CCI with pyruvate treatments begun 1h post-CCI.	Hydrogen	138-140	carbonic anhydrase 3	Rattus norvegicus	12-15
20673745-7	2010	These data suggest that the interaction of H2 with A28 stabilizes the immunogenic form of A28, mimicking an exposed region of the entry-fusion complex on infectious virions.	Hydrogen	43-45	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	51-54
20673745-7	2010	These data suggest that the interaction of H2 with A28 stabilizes the immunogenic form of A28, mimicking an exposed region of the entry-fusion complex on infectious virions.	Hydrogen	43-45	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	90-93
35505126-2	2022	The fabricated NixSy@MnOxHy/NF shows outstanding bifunctional activity and stability for hydrogen evolution reaction and oxygen evolution reaction, as well as overall-water-splitting performance.	Hydrogen	89-97	neurofascin	Homo sapiens	28-30
20398434-2	2010	Lactose hydrogen breath test (H2-BT) is considered the gold standard to evaluate LCT deficiency (LD).	Hydrogen	8-16	H2B clustered histone 20, pseudogene	Homo sapiens	30-35
35510894-0	2022	A Molten-Salt Method to Synthesize Co9 S8 Embedded, N, S Co-Doped Mesoporous Carbons from Melamine Formaldehyde Resins for Electrocatalytic Hydrogen Evolution Reactions.	Hydrogen	140-148	phosphoserine phosphatase pseudogene 1	Homo sapiens	35-38
20623827-2	2010	The syn conformation of E and Z isomers of pyrrole-2-carbaldehyde oxime is stabilized by the N-H...N and N-H...O intramolecular hydrogen bonds, respectively.	Hydrogen	128-136	synemin	Homo sapiens	4-7
20623827-6	2010	The calculations of (1)H shielding and (1)J(N, H) coupling in the syn and anti conformations allow the contribution to these constants from the N-H...N and N-H...O hydrogen bondings to be estimated.	Hydrogen	164-172	synemin	Homo sapiens	66-69
20977417-6	2010	In addition to the hydrophobic character, hydrogen bond donating groups positively contributes to the HDAC inhibition whereas electron withdrawing groups has a negative influence in HDAC inhibitory potency.	Hydrogen	42-50	histone deacetylase 9	Homo sapiens	102-106
35528164-0	2022	Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway.	Hydrogen	10-18	stearoyl-CoA desaturase	Homo sapiens	65-69
20726654-2	2010	The calculated results show that the hydrogen bond symmetrization (Cmc2(1)--&gt;Cmcm transition) of HBr and HCl occurs at 25 and 40 GPa, respectively, which can be attributed to the symmetry stretching A(1) mode softening.	Hydrogen	37-45	C-X9-C motif containing 2	Homo sapiens	67-71
35470452-5	2022	Incidence of HSR in the cohort treated with H2 antagonists was 11.31% (n=70) versus 9.86% (n=41) in the cohort without.	Hydrogen	44-46	HSR	Homo sapiens	13-16
20842834-2	2010	The results showed that, by comparison with the control, there were distinct differences in the experimental groups except the group of storage at -20 degrees C. Therefore, It is possible to use 1H-NMR-based metabonomics technique for analysis of HAF; moreover, during the tests, careful treatments of HAF should be institued to minimize the influence on the samples.	Hydrogen	195-197	coagulation factor XII	Homo sapiens	247-250
20842834-2	2010	The results showed that, by comparison with the control, there were distinct differences in the experimental groups except the group of storage at -20 degrees C. Therefore, It is possible to use 1H-NMR-based metabonomics technique for analysis of HAF; moreover, during the tests, careful treatments of HAF should be institued to minimize the influence on the samples.	Hydrogen	195-197	coagulation factor XII	Homo sapiens	302-305
20354783-8	2010	Hydrogen-rich saline increased the release of BDNF.	Hydrogen	0-8	brain-derived neurotrophic factor	Rattus norvegicus	46-50
20354783-9	2010	In conclusion, hydrogen-rich saline reduced acute spinal cord contusion injury, possibly by reduction of oxidative stress and elevation of BDNF.	Hydrogen	15-23	brain-derived neurotrophic factor	Rattus norvegicus	139-143
20435084-3	2010	It was found that the protein level of PKC and PKC-betaII (but not PKC-alpha) in cerebral cortex microvessels increased significantly at 0.5h and 1h after EMP exposure compared with sham-exposed animals and then recovered at 3h.	Hydrogen	146-148	protein kinase C, alpha	Rattus norvegicus	39-42
20403340-10	2010	Treatment with curcumin either 1h before or immediately after LPS injection significantly ameliorated white matter injury and loss of preOLs, decreased activated microglia, and inhibited microglial expression of iNOS and translocation of p67phox and gp91phox to the microglial cell membranes in neonatal rat brains following LPS injection.	Hydrogen	31-33	cytochrome b-245 beta chain	Rattus norvegicus	250-258
19554557-4	2010	The computational results reveal that the rate-determining step of the AHAS-catalyzed reactions is the second reaction step and that the most important amino acid residues involved in the catalysis include Glu144", Gln207", Gly121", and Gly511 that form favorable hydrogen bonds with the reaction center (consisting of atoms from the substrate and cofactor) during the reaction process.	Hydrogen	264-272	ilvB acetolactate synthase like	Homo sapiens	71-75
20620318-11	2010	Immunoreactivity of Msx1 and Msx2 at 1H was remarkably decreased in Cd group compared with controls.	Hydrogen	37-39	msh homeobox 1	Gallus gallus	20-24
20356026-8	2010	The TPR/D study has shown the evolution of the products of H(2), CH(4), H(2)O, CO, CO(2), CH(2)CO, and CH(3)COOH from CH(3)COO decomposition between 500 and 600 K and the formation of H(2) and CO from CCOH between 600 and 700 K. However, at a coverage near one monolayer, the major species formed at 230 and 320 K are proposed to be ICH(2)COO and CH(3)COO.	Hydrogen	59-63	translocated promoter region, nuclear basket protein	Homo sapiens	4-7
20423074-0	2010	Impact of distal mutation on hydrogen transfer interface and substrate conformation in soybean lipoxygenase.	Hydrogen	29-37	linoleate 9S-lipoxygenase-4	Glycine max	95-107
20390188-16	2010	On the contrary, the spectrophotometric titrations of 1 : 1 molar solution of 2 and OAc(-) or F(-) anion suggest the initial formation of hydrogen bonds between the N-H protons of LH(2) in 2 and the anion with the calculated log K value of 5.92 or 4.7, respectively, which eventually leads to the transfer of one of the N-H protons of LH(2) in 2 to the anion, resulting in 1 and HOAc or HF.	Hydrogen	138-146	hypoacusis 2 (autosomal recessive)	Homo sapiens	379-389
20036162-9	2010	Hydrogen treatment alone significantly reduced malondialdehyde levels and serum high-mobility group box 1 protein levels as compared with air-treated controls.	Hydrogen	0-8	high mobility group box 1	Rattus norvegicus	80-105
20235592-7	2010	As for the large dynamic range, comparisons between MM-GB/SA and FEP calculations indicate that for the factor Xa test set this problem has its origin in the lack of shielding effects of protein--ligand electrostatic interactions; that overly favors ligands that engage in hydrogen bonds with the protein.	Hydrogen	273-281	coagulation factor X	Homo sapiens	104-113
20225877-3	2010	The FTIR analysis indicated that grafted AAc into zein/PVA matrix was stabilized by hydrogen bonding.	Hydrogen	84-92	glycine-N-acyltransferase	Homo sapiens	41-44
20025931-8	2010	The ligands stayed longer in the catalytically active position in mSULT1E1, which is likely a result of simultaneous hydrogen bond formation on both sides of the binding pocket, which does not seem to be possible in hSULT1E1.	Hydrogen	117-125	sulfotransferase family 1E, member 1	Mus musculus	66-74
20184897-8	2010	A strong hydrogen bond between these ends, which are located respectively on the first and the last beta-strands, leads to formation of an almost straight edge in PSP94 structure.	Hydrogen	9-17	microseminoprotein beta	Homo sapiens	163-168
20036291-7	2010	MCAO (1h) and 24h reperfusion caused a brain infarction of 23% (compared to the contralateral side) in NRP2(-/-) mice, which is not different from those in NRP2(+/- and +/+) mice at 22 and 21%, respectively (n=19, p&gt;0.05).	Hydrogen	6-8	neuropilin 2	Mus musculus	103-107
19796713-5	2010	In fully active CK2alpha the hinge region is open and does not anchor the ATP ribose, but alternatively it can adopt a closed conformation, form hydrogen bonds to the ribose moiety and thus retract the gamma-phospho group from its functional position.	Hydrogen	145-153	casein kinase 2 alpha 2	Homo sapiens	16-24
20124688-2	2010	Polymorph (It) (P-1, Z = 1) displays the standard ;ladder" packing for this group of compounds, with neighbouring inversion-symmetric molecules related by translation and connected by hydrogen bonds of the form N-H...O=C.	Hydrogen	184-192	crystallin gamma F, pseudogene	Homo sapiens	16-26
19551886-1	2010	In the present work, we have found by an atomistic molecular dynamics simulation that hydrogen atoms originating from the residues of a prokaryotic ClC protein (EcClC) stabilize the chloride ion without water molecules in the pore of ClC protein.	Hydrogen	86-94	Charcot-Leyden crystal galectin	Homo sapiens	148-151
19858003-3	2010	In the present study 1h treatment with 25muM etoposide was highly toxic and initiated a double-stranded DNA damage response as reflected by the recruitment of ATM, MDC1 and DNA-PKcs to gammaH2AX foci.	Hydrogen	21-23	mediator of DNA damage checkpoint 1	Homo sapiens	164-168
19782136-2	2010	In vitro studies have shown that short-term application of beta-amyloid (Abeta) peptides to isolated vessels affects vascular tone within 1h, but no studies have examined the effect of long-term incubation with Abeta.	Hydrogen	138-140	amyloid beta precursor protein	Rattus norvegicus	59-79
19782136-2	2010	In vitro studies have shown that short-term application of beta-amyloid (Abeta) peptides to isolated vessels affects vascular tone within 1h, but no studies have examined the effect of long-term incubation with Abeta.	Hydrogen	138-140	amyloid beta precursor protein	Rattus norvegicus	73-78
20060383-4	2010	Detailed structural analysis shows that a difference in the conformation of the connecting loop (beta15-beta16) causes the formation of a water molecule-mediated hydrogen bond network between the connecting loop and the catalytic loop in EcSSADH, making the catalytic loop of EcSSADH more rigid compared to that of human SSADH.	Hydrogen	162-170	aldehyde dehydrogenase 5 family member A1	Homo sapiens	240-245
19876967-4	2010	The beta N--O turns or beta N--O helices, which feature nine-membered rings with intramolecular hydrogen bonds and have been identified previously in peptides of beta(3)- and beta(2, 2)-aminoxy acids, are also predominantly present in the acyclic beta(2, 3)-aminoxy peptides with a syn configuration and N--O bonds gauche to the C(alpha)--C(beta) bonds in both solution and the solid state.	Hydrogen	96-104	synemin	Homo sapiens	282-285
20564041-6	2010	The Gpn residue can adopt both C(7) (NH(i) CO(i)) and C(9) (CO(i-1) NH(i+1)) hydrogen bonds which are analogous to the C(5) and C(7) (gamma-turn) conformations at alpha-residues.	Hydrogen	77-85	complement C9	Homo sapiens	54-58
19506924-5	2010	In particular the replacement of serine 256 and isoleucine 359 in LeuT(Aa) with glycine and threonine in hGAT-1 seems to facilitate the selection of GABA as the main substrate by changing the hydrogen bonding pattern in the active site to the amino group of the substrate.	Hydrogen	192-200	Leucine transport, high	Homo sapiens	66-70
20025317-10	2009	Finally, the method is applied to include the electronic correlation needed to describe the van der Waals interaction between H(10) chains and H(2) molecules, of approximately 12 meV, giving very accurate results.	Hydrogen	143-147	H1.0 linker histone	Homo sapiens	126-131
35420032-0	2022	Isotopological Fingerprinting Using 1H/D Scrambling Identifies the Stereochemistry of Hyperpolarization Catalysts Transferring Spin Polarization from Parahydrogen to Substrates Using Signal Amplification by Reversible Exchange.	Hydrogen	36-38	spindlin 1	Homo sapiens	127-131
19835883-14	2009	The observed interaction site between CAT-2200 and IL-17A is consistent with data from hydrogen/deuterium exchange mass spectrometry and mutagenesis approaches.	Hydrogen	87-95	interleukin 17A	Homo sapiens	51-57
35296453-7	2022	The lead inhibitor interacted with FAAH and MAGL via pi-pi stacking via phenyl ring and hydrogen bonding through sulfonyl oxygen atoms or amide NH.	Hydrogen	88-96	monoglyceride lipase	Homo sapiens	44-48
19674816-1	2009	The best ZAP-70 inhibitor model consists of four-pharmacophore features, (1) one hydrogen bond acceptor, (2) one hydrogen bond donor (3) one hydrophobic aliphatic and (4) one hydrophobic aromatic features.	Hydrogen	81-89	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	9-15
35474810-4	2022	It was concluded that hydrogen bond formation and steric hindrance were the main factors affecting the correct assignment for Boc-aminoalcohols.	Hydrogen	22-30	BOC cell adhesion associated, oncogene regulated	Homo sapiens	126-129
19674816-1	2009	The best ZAP-70 inhibitor model consists of four-pharmacophore features, (1) one hydrogen bond acceptor, (2) one hydrogen bond donor (3) one hydrophobic aliphatic and (4) one hydrophobic aromatic features.	Hydrogen	113-121	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	9-15
35167308-4	2022	Conversely, the chemisorbed hydrogen atom governs the pi-magnetism of ZGNRs, acting as a spin-1/2 paramagnetic center in the otherwise antiferromagnetic ground state and spin-polarizing the charge carriers at the band extrema.	Hydrogen	28-36	spindlin 1	Homo sapiens	89-97
19631739-8	2009	PCL leads to decrease in the release kinetics in SIF (2h for alginate-g-PCL/Ca2+ beads against 1h for alginate/Ca2+ beads).	Hydrogen	95-97	PHD finger protein 1	Homo sapiens	0-3
35212342-3	2022	Therein, we observed two deuteron quadrupole coupling constant for the ND bond of the TEA cation, indicating differently strong hydrogen bonds to the nitrogen and oxygen atoms of the NTf2 anion, as we could confirm by DFT calculations.	Hydrogen	128-136	nuclear transport factor 2	Homo sapiens	183-187
20161397-0	2009	Gas-Phase Hydrogen/Deuterium Exchange of Dinucleotides and 5"-Monophosphate Dinucleotides in a Quadrupole Ion Trap.	Hydrogen	10-18	TRAP	Homo sapiens	110-114
35174844-0	2022	AlP-regulated phosphorus vacancies over Ni-P compounds promoting efficient and durable hydrogen generation in acidic media.	Hydrogen	87-95	ATHS	Homo sapiens	0-3
20161397-1	2009	Gas-phase hydrogen/deuterium (H/D) exchange reactions of four deprotonated dinucleotides (dAA, dAG, dGA, dGG) and their 5"-monophosphate analogs (5"-dAA, 5"-dAG, 5"-dGA, 5"-dGG) with D(2)O were performed in a quadrupole ion trap mass spectrometer.	Hydrogen	10-18	TRAP	Homo sapiens	224-228
19719165-2	2009	Preformed, hydrogen-bonded multilayers of alkyne-functionalized poly(N-vinyl pyrrolidone) (PVPON(Alk)) and poly(methacrylic acid) (PMA) assembled at pH 4 on silica particles were cross-linked with a bisazide linker (containing a disulfide link) through alkyne-azide click chemistry.	Hydrogen	11-19	ALK receptor tyrosine kinase	Homo sapiens	97-100
35091289-0	2022	Design, synthesis, in vitro antiproliferative evaluation and in silico studies of new VEGFR-2 inhibitors based on 4-piperazinylquinolin-2(1H)-one scaffold.	Hydrogen	138-140	kinase insert domain receptor	Homo sapiens	86-93
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Hydrogen	127-135	kelch-like ECH-associated protein 1	Mus musculus	107-112
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Hydrogen	127-135	kelch-like ECH-associated protein 1	Mus musculus	192-197
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Hydrogen	127-135	NAD(P)H dehydrogenase, quinone 1	Mus musculus	351-355
19719165-3	2009	Following dissolution of the silica template particles, and altering the solution pH to 7.2 to disrupt hydrogen bonding between PVPON(Alk) and PMA to effect removal of PMA, stable, cross-linked PVPON capsules were obtained.	Hydrogen	103-111	ALK receptor tyrosine kinase	Homo sapiens	134-137
19725498-0	2009	Metal-ligand cooperation in H2 production and H2O decomposition on a Ru(II) PNN complex: the role of ligand dearomatization-aromatization.	Hydrogen	28-30	pinin, desmosome associated protein	Homo sapiens	76-79
35190699-11	2022	A molecular docking simulation and point mutation and pulldown assays identified Z16b forms hydrogen bonds with Arg626, His1670, and Gln2126 in RyR2 as a triangle shape that anchors the NTD and CD interaction and thus stabilizes RyR2 in a tight "zipping" conformation.	Hydrogen	92-100	ryanodine receptor 2, cardiac	Mus musculus	144-148
35190699-11	2022	A molecular docking simulation and point mutation and pulldown assays identified Z16b forms hydrogen bonds with Arg626, His1670, and Gln2126 in RyR2 as a triangle shape that anchors the NTD and CD interaction and thus stabilizes RyR2 in a tight "zipping" conformation.	Hydrogen	92-100	cathepsin D	Mus musculus	194-196
35190699-11	2022	A molecular docking simulation and point mutation and pulldown assays identified Z16b forms hydrogen bonds with Arg626, His1670, and Gln2126 in RyR2 as a triangle shape that anchors the NTD and CD interaction and thus stabilizes RyR2 in a tight "zipping" conformation.	Hydrogen	92-100	ryanodine receptor 2, cardiac	Mus musculus	229-233
35168606-6	2022	RESULTS: On in vivo 1H-MRS, the ratio of (glycerophosphocholine + phosphocholine) to (creatine + phosphocreatine) ((GPC + PC) to (Cr + PCr))(i.e. Cho/Cr) in the PTX-resistant tumors (1.64 (0.69, 4.18)) was significantly higher than that in the PTX-sensitive tumors (0.33 (0.10, 1.13)) (P = 0.04).	Hydrogen	20-22	glycophorin C (Gerbich blood group)	Homo sapiens	116-119
19586907-3	2009	By comparing the structures, it was determined that the specificity of the relative inhibitors for ADAMTS-5 was not driven by a specific interaction, such as zinc chelation, hydrogen bonding, or charge interactions, but rather by subtle and indirect factors, such as water bridging, ring rigidity, pocket size, and shape, as well as protein conformation flexibility.	Hydrogen	174-182	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	99-107
35214371-0	2022	PLL-Based Readout Circuit for SiC-MOS Capacitor Hydrogen Sensors in Industrial Environments.	Hydrogen	48-56	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	34-37
35214371-4	2022	The PLL converts the MOS nonlinear small-signal capacitance (affected by hydrogen) into an output voltage proportional to the detected gas concentration.	Hydrogen	73-81	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	21-24
19501449-5	2009	The STD profile of backbone amide protons is in good agreement with an earlier computational study predicting hydrogen bonding propensity for each residue in small TTR(105-115) aggregates (Paci et al., J. Mol.	Hydrogen	110-118	transthyretin	Homo sapiens	164-167
35085233-6	2022	In addition, the results of molecular docking revealed that the 5 sterols were located in different pocket of COX-1 and -2 and fucosterol with tetracyclic skeletons and olefin methine achieved the highest binding energy (-7.85 and -9.02 kcal/mol) through hydrophobic interactions and hydrogen bond.	Hydrogen	284-292	cox1	Saccharina japonica	110-122
19702528-6	2009	CYP2A6 shows a crystal structure with a compact, hydrophobic active site with Asn297 serving as one hydrogen bond donor and orienting substrates for regio-selective oxidation.	Hydrogen	100-108	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
35164091-8	2022	These compounds specifically mediating hydrogen bonding with Thr199, Thr200, Gln92 of CA-II.	Hydrogen	39-47	carbonic anhydrase 2	Homo sapiens	86-91
19556451-6	2009	Increased Na(+) uptake was paralleled by increased apical surface abundance of the sodium/hydrogen exchangers NHE2 and NHE3.	Hydrogen	90-98	solute carrier family 9 member A2	Homo sapiens	110-114
19556451-6	2009	Increased Na(+) uptake was paralleled by increased apical surface abundance of the sodium/hydrogen exchangers NHE2 and NHE3.	Hydrogen	90-98	solute carrier family 9 member A3	Homo sapiens	119-123
19722655-3	2009	The BDE difference between 1 and one-electron oxidized species, [Ru(III)(dmp(-))(TPA)](2+), was determined to be 89 kcal mol(-1), which was large enough to achieve hydrogen atom transfer (HAT) from phenol derivatives.	Hydrogen	164-172	homeobox D13	Homo sapiens	4-7
19722675-2	2009	Left to their own devices they both adopt a cis (anti-phi/syn-psi) glycosidic configuration, supported in the epimer by strong, cooperative inter-ring hydrogen bonding.	Hydrogen	151-159	synemin	Homo sapiens	58-61
19360839-2	2009	The shortest oligomer, Boc-(L-Phe-D-Oxd)(2)-OBn, aggregates and forms a fiber-like material with an anti-parallel beta-sheet structure in which the oligopeptide units are connected to each other by only one intermolecular hydrogen bond.	Hydrogen	222-230	BOC cell adhesion associated, oncogene regulated	Homo sapiens	23-26
19298826-4	2009	Changes in the rate of hydrogen exchange indicate that ATP binding causes conformational rearrangements of Arp2 and Arp3 that are transmitted allosterically to the Arp complex (ARPC)1, ARPC2, ARPC4, and ARPC5 subunits.	Hydrogen	23-31	actin related protein 3	Homo sapiens	116-120
19426743-7	2009	The interactions between the AN3018-AMP adduct and C. albicans LeuRS are similar to those previously observed for bacterial LeuRS with the AN2690 adduct, with an additional hydrogen bond to the extra ethylamine group.	Hydrogen	173-181	leucyl-tRNA synthetase 1	Homo sapiens	63-68
19426743-7	2009	The interactions between the AN3018-AMP adduct and C. albicans LeuRS are similar to those previously observed for bacterial LeuRS with the AN2690 adduct, with an additional hydrogen bond to the extra ethylamine group.	Hydrogen	173-181	leucyl-tRNA synthetase 1	Homo sapiens	124-129
19473005-5	2009	Mesitylene is readily displaced by NB to form an agostic intermediate in which NB acts as a bidentate ligand and binds to the cationic Pd center via the pi-system and a gamma-agostic interaction with the syn hydrogen at C7.	Hydrogen	208-216	synemin	Homo sapiens	204-207
19394883-2	2009	Isotope substitution of deuterium for hydrogen in water and studies at different temperatures expose three classes of water molecule dynamics that contribute to the spin-lattice relaxation dispersion profile.	Hydrogen	38-46	spindlin 1	Homo sapiens	165-169
19391098-6	2009	When both charge and spin are on the peptide backbone, as in [GGG]*+, captodative structures have the lowest energies; the barriers to interconversion between the three isomeric alpha-radicals of [GGG]*+ are high as the charge impedes migration of a hydrogen atom.	Hydrogen	250-258	spindlin 1	Homo sapiens	21-25
19341285-1	2009	Hybrid peptide segments containing contiguous alpha and gamma amino acid residues can form C(12) hydrogen bonded turns which may be considered as backbone expanded analogues of C(10) (beta-turns) found in alphaalpha segments.	Hydrogen	97-105	chromosome 12 open reading frame 57	Homo sapiens	177-182
19355752-6	2009	Finally, spin-spin coupling constants across hydrogen bonds are discussed considering for the first time the role of an explicit solvent on this class of spin-spin couplings.	Hydrogen	45-53	spindlin 1	Homo sapiens	9-13
19355752-6	2009	Finally, spin-spin coupling constants across hydrogen bonds are discussed considering for the first time the role of an explicit solvent on this class of spin-spin couplings.	Hydrogen	45-53	spindlin 1	Homo sapiens	14-18
19355752-6	2009	Finally, spin-spin coupling constants across hydrogen bonds are discussed considering for the first time the role of an explicit solvent on this class of spin-spin couplings.	Hydrogen	45-53	spindlin 1	Homo sapiens	14-18
19355752-6	2009	Finally, spin-spin coupling constants across hydrogen bonds are discussed considering for the first time the role of an explicit solvent on this class of spin-spin couplings.	Hydrogen	45-53	spindlin 1	Homo sapiens	14-18
19226157-1	2009	We report here that the monodentate complexation of Me2AlCl to an ester group significantly enhances the selectivity of hydrogen transfer on acyclic radicals flanked by both an ester functionality and a stereogenic center, leading to C-2,C-3-anti products with high diastereoselectivity.	Hydrogen	120-128	complement C3	Homo sapiens	238-241
19103207-5	2009	And the complex models suggest that BH3 domain of BAD interact with PKAc or PP1c by electrostatic, van der Waals contacts, hydrogen bond and salt bridge.	Hydrogen	123-131	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	76-80
19118093-10	2009	Collectively, T/HS-induced pulmonary endothelial PCD occurs via an AIF-dependent caspase-independent pathway, whereas epithelial cells undergo apoptosis by a caspase-dependent pathway.	Hydrogen	16-18	apoptosis inducing factor mitochondria associated 1	Homo sapiens	67-70
19115942-1	2009	N-(2-Mercaptopropionyl glycine)-passivated gold clusters (Au-MPG) represent a unique networked system of monolayer-protected clusters (MPCs) due to inter- and/or intramolecular hydrogen bonding between the MPC units thanks to the terminal carboxylic acid groups of the monolayers.	Hydrogen	177-185	N-methylpurine DNA glycosylase	Homo sapiens	61-64
19028005-0	2009	A systematic study on hydrogen bond interactions in sulfabenzamide: DFT calculations of the N-14, O-17, and H-2 NQR parameters.	Hydrogen	22-30	SS nuclear autoantigen 1	Homo sapiens	92-96
19196184-9	2009	We further show the relevance of synthetic HS/heparin for the binding of NCRs to tumor cells and for NCR-mediated activation of natural killer cells.	Hydrogen	43-45	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	73-76
19182802-3	2009	Distance measurements using solid-state (13)C NMR spectroscopy between the retinal chromophore and the beta4 strand of EL2 show that the loop is displaced from the retinal binding site upon activation, and there is a rearrangement in the hydrogen-bonding networks connecting EL2 with the extracellular ends of transmembrane helices H4, H5 and H6.	Hydrogen	238-246	spectrin alpha, erythrocytic 1	Homo sapiens	119-122
19180615-0	2009	STM insight into hydrogen-bonded bicomponent 1D supramolecular polymers with controlled geometries at the liquid-solid interface.	Hydrogen	17-25	sulfotransferase family 1A member 3	Homo sapiens	0-3
18805459-6	2008	The mean number of c-Fos positive neurons in the layers II-III began to increase at 1h and reached a peak at 2h after BV treatment that was followed by a gradual decrease afterward.	Hydrogen	84-86	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	19-24
35163974-7	2022	Furthermore, non-covalent interaction (NCI) plots show that cooperative non-covalent interactions, namely, hydrogen and halogen bonds, contribute to the binding of tubercidin ligands toward Haspin.	Hydrogen	107-115	histone H3 associated protein kinase	Homo sapiens	190-196
19006380-5	2008	A 4-fold enhancement of the inhibitor activity upon replacement of the 4-CH2 group of the proline ring by CF2 is a consequence of a weak hydrogen bond formed between the fluorine atom and the hydroxy group of Tyr473 of the host enzyme.	Hydrogen	137-145	ATPase H+ transporting accessory protein 1	Homo sapiens	106-109
19636891-0	2008	1H, 13C, and 15N resonance assignment of the ubiquitin-like domain from Dsk2p.	Hydrogen	0-2	ubiquitin domain-containing protein DSK2	Saccharomyces cerevisiae S288C	72-77
18536011-9	2008	The introduction of a polar ligand such as glycine to the water-depleted binding pocket of LeuT gives rise to structural rearrangements of the R30-D404-Q250 hydrogen-bonding network and leads to increased hydration of the binding pocket.	Hydrogen	157-165	Leucine transport, high	Homo sapiens	91-95
18536011-10	2008	Conformational changes associated with the broken hydrogen bond between Q250 and R30 are shown to be important for tight and selective ligand binding to LeuT.	Hydrogen	50-58	Leucine transport, high	Homo sapiens	153-157
18973379-6	2008	In the examination of the mechanism of the ubquinol oxidation, it was confirmed that the ubiquinol docks between the imidazolate of [2Fe-2S] clusters and Glu272(-) of cytochrome b by the hydrogen bonds before the oxidation proceeds, consistent with the experimental proposals.	Hydrogen	187-195	mitochondrially encoded cytochrome b	Homo sapiens	167-179
18834105-3	2008	The results suggest that substituents endowed with hydrogen bonding acceptor and/or donor properties in the para position of the phenyl ring lead to high affinity for PBR.	Hydrogen	51-59	translocator protein	Homo sapiens	167-170
18846302-1	2008	Hydrogen/deuterium exchange in reactions of H3O(+)(H2O)n and NH4(+)(H2O)n (1 &lt; or = n &lt; or = 30) with D2O has been studied experimentally at center-of-mass collisions energies of &lt; or = 0.2 eV.	Hydrogen	0-8	H3 clustered histone 15	Homo sapiens	44-47
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Hydrogen	271-279	CD44 molecule (Indian blood group)	Homo sapiens	26-30
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Hydrogen	271-279	CD44 molecule (Indian blood group)	Homo sapiens	184-188
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Hydrogen	271-279	CD44 molecule (Indian blood group)	Homo sapiens	184-188
18940604-5	2008	The Rab27B/Slac2-a complex exhibits several intermolecular hydrogen bonds that were not observed in the previously reported Rab3A/rabphilin complex.	Hydrogen	59-67	RAB27B, member RAS oncogene family	Homo sapiens	4-10
18940604-6	2008	A Rab27A mutation that disrupts one of the specific hydrogen bonds with Slac2-a resulted in the dramatic reduction of Slac2-a binding activity.	Hydrogen	52-60	RAB27A, member RAS oncogene family	Homo sapiens	2-8
18712869-2	2008	The back conversion from para-hydrogen ( p-H 2) to ortho-hydrogen ( o-H 2) was followed by NMR by recording the increase in the intensity of the signal of o-H 2 at regular intervals of time.	Hydrogen	25-38	polyhomeotic homolog 2	Homo sapiens	41-46
18712869-2	2008	The back conversion from para-hydrogen ( p-H 2) to ortho-hydrogen ( o-H 2) was followed by NMR by recording the increase in the intensity of the signal of o-H 2 at regular intervals of time.	Hydrogen	30-38	polyhomeotic homolog 2	Homo sapiens	41-46
18796606-5	2008	The use of regiospecifically deuterated substrates shows that the conversion of (Z)-9-18:1 substrate to (E)-10-18:1-9-OH product proceeds via hydrogen abstraction at C-11 and highly regioselective hydroxylation (&gt;97%) at C-9.	Hydrogen	142-150	RNA polymerase III subunit K	Homo sapiens	166-170
18774300-4	2008	D-Trp is anchored at the edge of the CA II active site entrance, strongly interacting with amino acid residues Asp130, Phe131 and Gly132 as well as with a loop of a second symmetry related protein molecule from the asymmetric unit, by means of hydrogen bonds and several weak van der Waals interactions involving Glu234, Gly235, Glu236 and Glu238.	Hydrogen	244-252	carbonic anhydrase 2	Homo sapiens	37-42
19093556-11	2008	With the increase in acid content in the TBP organic phases, the observed 31P NMR chemical shifts decreased and varied to up-field; whereas the 1H NMR chemical shift of H+ increased and even became larger than that of deuterium chloride-d at a lower frequency field.	Hydrogen	144-146	TATA-box binding protein	Homo sapiens	41-44
18652435-1	2008	A novel, nonadiabatic reaction path for H2 + CO molecular dissociation of formaldehyde via an extended S1/S0 conical intersection seam has been mapped out using the CAS-SCF method with a full valence active space (10 electrons, 9 orbitals).	Hydrogen	40-42	KIT ligand	Homo sapiens	169-172
18666767-3	2008	Hydrogen and halogen bond formation or molecular recognition between PK1 and decanoic acid (DCA), n-decyl alcohol (DA), 1,10-dibromodecane (DBr), and n-decyl sulfonic acid (DSA) was investigated in comparison with undoped PK1.	Hydrogen	0-8	prokineticin 1	Homo sapiens	69-72
18666767-3	2008	Hydrogen and halogen bond formation or molecular recognition between PK1 and decanoic acid (DCA), n-decyl alcohol (DA), 1,10-dibromodecane (DBr), and n-decyl sulfonic acid (DSA) was investigated in comparison with undoped PK1.	Hydrogen	0-8	prokineticin 1	Homo sapiens	222-225
18570408-2	2008	Structural studies of ternary complexes of human dCK show that the enzyme conformation adjusts to the different hydrogen-bonding properties between dA and dG and to the presence of substituent at the 2-position present in dG and cladribine.	Hydrogen	112-120	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	49-52
18502031-7	2008	Injection of a progestin antagonist RU486 or an inhibitor of 3beta-hydroxysteroid dehydrogenase epostane at 1h before hCG treatment inhibited hCG-induced Pcsk5 mRNA levels.	Hydrogen	108-110	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	154-159
18417576-8	2008	Mutations with the most pronounced effect on infectivity disrupted the interaction of H2 with A28 to the greatest extent in both infected and uninfected cells.	Hydrogen	86-88	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	94-97
18417576-9	2008	These data indicate that the LGYSG sequence is important for the interaction of H2 with A28 and suggest that this sequence is buried within the EFC complex.	Hydrogen	80-82	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	88-91
18522382-3	2008	The lowest-energy conformers of eugenol (SAA+, SAA- and SAS) stabilized by the intramolecular hydrogen bond differ only in the arrangement of the allyl group with respect to the aromatic ring.	Hydrogen	94-102	serum amyloid A1 cluster	Homo sapiens	41-44
18522382-3	2008	The lowest-energy conformers of eugenol (SAA+, SAA- and SAS) stabilized by the intramolecular hydrogen bond differ only in the arrangement of the allyl group with respect to the aromatic ring.	Hydrogen	94-102	serum amyloid A1 cluster	Homo sapiens	47-50
18479122-1	2008	A new Cu2+ compound Cu- NB, (where H2 NB is bis(2-hydroxyl-naphthalene-carboxaldehyde) benzil dihydrazone) was synthesized as a highly selective fluorescence chemosensor for the detection of Hg2+ in aqueous media through a displacement "turn-on" signaling strategy.	Hydrogen	35-37	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	191-194
18457426-2	2008	All three residues are also conserved in fXa and the X-ray crystal structure of fXa indicates that both Glu-217 and Lys-224 are within hydrogen-bonding distance from one another.	Hydrogen	135-143	coagulation factor X	Homo sapiens	80-83
19636910-0	2008	Assignment of 1H, 13C, and 15N resonances of the RNA binding protein Snu13p from Saccharomyces cerevisiae.	Hydrogen	14-16	RNA binding protein SNU13	Saccharomyces cerevisiae S288C	69-75
18356111-3	2008	In the current study, the possibility of contributions to indirect readout by water-mediated hydrogen bonding of CRP with the T:A base pair was investigated.	Hydrogen	93-101	catabolite gene activator protein	Escherichia coli	113-116
18356111-4	2008	A 1.0 ns molecular dynamics simulation of the CRP-cAMP-DNA complex in explicit solvent was performed, and assessed for water-mediated CRP-DNA hydrogen bonds; results were compared to several X-ray crystal structures of comparable complexes.	Hydrogen	142-150	catabolite gene activator protein	Escherichia coli	46-49
18356111-4	2008	A 1.0 ns molecular dynamics simulation of the CRP-cAMP-DNA complex in explicit solvent was performed, and assessed for water-mediated CRP-DNA hydrogen bonds; results were compared to several X-ray crystal structures of comparable complexes.	Hydrogen	142-150	catabolite gene activator protein	Escherichia coli	134-137
18356111-5	2008	While several water-mediated CRP-DNA hydrogen bonds were identified, none of these involved the T:A base pair at position 6.	Hydrogen	37-45	catabolite gene activator protein	Escherichia coli	29-32
18493652-2	2008	We synthesized palmitic acid with carbons C-3 through C-16 perdeuterated, C-1 and C-2 with 13C atoms and hydrogens at C-2.	Hydrogen	105-114	complement C3	Homo sapiens	42-45
18438399-6	2008	Instead, phosphorylation of HP1-beta on amino acid Thr 51 accompanies mobilization, releasing HP1-beta from chromatin by disrupting hydrogen bonds that fold its chromodomain around H3K9me.	Hydrogen	132-140	chromobox 1	Homo sapiens	28-36
18410148-3	2008	The upfield carbinol hydrogen signal belongs to the anti whereas the downfield to the syn stereoisomer.	Hydrogen	21-29	synemin	Homo sapiens	86-89
18041758-6	2008	A bifurcated donor type hydrogen bonding involving O3H, N3, and N4 is seen as an important structural motif strengthening the binding of glucosyltriazolylacetamide with GP which necessitated change in the torsion about C8-N2 bond by about 62 degrees going from its free to the complex form with GPb.	Hydrogen	24-32	glycogen phosphorylase B	Homo sapiens	295-298
18661740-6	2008	Data obtained through TGA (Thermogravimetric analysis), XRD (X-ray diffraction) and toluene-TPR (Temperature Programmed Reduction) measurements show that the reduction of the catalysts in the process of toluene oxidation is directly proportional to observed weight loss under hydrogen flow.	Hydrogen	276-284	translocated promoter region, nuclear basket protein	Homo sapiens	92-95
18308600-0	2008	Spin state selective coherence transfer: a method for discrimination and complete analyses of the overlapped and unresolved 1H NMR spectra of enantiomers.	Hydrogen	124-126	spindlin 1	Homo sapiens	0-4
18359116-5	2008	Similarly, the half-life of a pathogenic PINK1 mutant (L347P) that did not interact with Hsp90 or Cdc37/p50 was only 30min, whereas that of wild-type PINK1 was 1h.	Hydrogen	160-162	PTEN induced kinase 1	Homo sapiens	150-155
18255335-5	2008	As an example we present here results obtained using EPR spectroscopy and the spin-trap DEPMPO, which show that the Fenton reaction, as well as various biological systems generate a previously unappreciated hydrogen (*H) atom.	Hydrogen	207-215	spindlin 1	Homo sapiens	78-82
18275838-2	2008	The 5"-phosphate of the PLP cofactor is very tightly bound to the enzyme; it accepts 8 hydrogen bonds from enzyme side chains and a pair of water molecules, and is in close proximity to a helix dipole.	Hydrogen	87-95	proteolipid protein 1	Homo sapiens	24-27
18572597-3	2008	K/GCNF intercalates act as radical-anion alkene polymerization catalysts and reduce water with stoichiometric formation of hydrogen gas.	Hydrogen	123-131	nuclear receptor subfamily 6 group A member 1	Homo sapiens	2-6
18088105-10	2008	As a result, the triplet products CH2 + CH2O, H + CH2CHO and OH + C2H3 dominate over the singlet products CH3 + CHO, H2 + CH2CO, etc.	Hydrogen	35-37	alien	Drosophila melanogaster	40-43
18271587-0	2008	Hydrogen bonding effects on the electronic configuration of five-coordinate high-spin iron(II) porphyrinates.	Hydrogen	0-8	spindlin 1	Homo sapiens	81-85
18096134-12	2008	After stimulation with motilin and EM-A the t(1/2) for MTLR resensitization was 3h and 1h, respectively but amounted 26h for ABT-229.	Hydrogen	87-89	Mlnr	Cricetulus griseus	55-59
18236442-1	2008	Interaction of H3O+ or H5O2+ with 1,3-alternate tetrapropoxycalix[4]arene (1) was studied in nitrobenzene and dichloromethane using 1H and 13C NMR including transverse and rotating-frame relaxations and density functional level of theory (DFT) quantum calculations.	Hydrogen	132-134	H3 clustered histone 15	Homo sapiens	15-18
18260012-7	2008	This amino acid preference suggests that CORE-binding peptides use pi-pi stacking to recognize the target while hydrogen bonding is dominant for AP2-binding peptides.	Hydrogen	112-120	transcription factor AP-2 alpha	Homo sapiens	145-148
18205401-4	2008	Mutations to amino acid residues in the vicinity of the nitrile functional group were selected based on electrostatics calculations, possible complications from hydrogen bonds near the nitrile, and comparison with the active site of human aldehyde reductase, whose structure is very similar.	Hydrogen	161-169	aldo-keto reductase family 1 member A1	Homo sapiens	239-257
18181651-5	2008	The analytical relationships show that the state of surface charge also influences the local hydrogen ion concentration, thus resulting in a substantial local shift in pH at the surface compared to the bulk solution as a function of the difference between the bulk solution pH and the pKd of the surface.	Hydrogen	93-101	protein kinase D1	Homo sapiens	285-288
18767124-5	2008	Solvent dependence of NH chemical shifts in CDCl(3) solution are consistent with conformation in which the NH groups of Aib (3), Leu (4), Gpn (5), and Aib (6) are hydrogen bonded, a feature observed in the solid state.	Hydrogen	163-171	ANIB1	Homo sapiens	120-123
18767124-5	2008	Solvent dependence of NH chemical shifts in CDCl(3) solution are consistent with conformation in which the NH groups of Aib (3), Leu (4), Gpn (5), and Aib (6) are hydrogen bonded, a feature observed in the solid state.	Hydrogen	163-171	ANIB1	Homo sapiens	151-154
17900862-0	2007	1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.	Hydrogen	0-2	receptor for activated C kinase 1	Mus musculus	216-221
17707780-9	2007	Moreover, the quantum chemical calculations indicated that the intermolecular hydrogen-bonding interactions play an essential role in determining the relative orientation of CS and EFG tensors of O-6 and nitrogen atoms in the molecular frame axes.	Hydrogen	78-86	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	196-199
17973533-6	2007	On the basis of a combination of several techniques including the 1H NMR, ESI-HRMS, and MM2 calculations, the proposed mechanism was presented to explain the origin of reactivity and asymmetric inductivity.	Hydrogen	66-68	PNMA family member 2	Homo sapiens	88-91
17935307-7	2007	In the presence of excess alcohol, syn --&gt; anti rotamerization occurs in the ground state, promoted by the cooperative action of nonspecific and specific effects such as solvent polarity increase and the formation of hydrogen bonds to both donor and acceptor sites of the bifunctional compounds.	Hydrogen	220-228	synemin	Homo sapiens	35-38
17526562-2	2007	The 10th FN-III domain from fibronectin (fnFN10) and the 3rd FN-III domain from tenascin-C (tnFN3) have 27% sequence identity and the same overall fold; however, the CC" loop has a different pattern of backbone hydrogen bonds and the FG loop is longer in fnFN10 compared to tnFN3.	Hydrogen	211-219	tenascin C	Homo sapiens	80-90
17545236-2	2007	To correlate the spectroscopic observations with structure a density function theory model was created that captures the essential hydrogen bonding and packing of the beta-spiral structure proposed for elastin and elastin-like polypeptides.	Hydrogen	131-139	elastin	Homo sapiens	202-209
17545236-2	2007	To correlate the spectroscopic observations with structure a density function theory model was created that captures the essential hydrogen bonding and packing of the beta-spiral structure proposed for elastin and elastin-like polypeptides.	Hydrogen	131-139	elastin	Homo sapiens	214-221
17892265-3	2007	DCVCS incubations with N-acetyl-L-cysteine (NAC) at pH 7.4 and 37 degrees C for 1 h resulted in the formation of three monoadducts and one diadduct characterized by LC/MS, 1H NMR, and 1H-detected heteronuclear single quantum correlation.	Hydrogen	172-174	X-linked Kx blood group	Homo sapiens	44-47
17892265-3	2007	DCVCS incubations with N-acetyl-L-cysteine (NAC) at pH 7.4 and 37 degrees C for 1 h resulted in the formation of three monoadducts and one diadduct characterized by LC/MS, 1H NMR, and 1H-detected heteronuclear single quantum correlation.	Hydrogen	184-186	X-linked Kx blood group	Homo sapiens	44-47
17632125-4	2007	The Ubp3 N-terminal domain binds within a hydrophobic cavity on the surface of the Bre5 NTF2-like domain subunit with conserved residues within both proteins interacting predominantly through antiparallel beta-sheet hydrogen bonds and van der Waals contacts.	Hydrogen	216-224	mRNA-binding ubiquitin-specific protease UBP3	Saccharomyces cerevisiae S288C	4-8
17468416-6	2007	Serum leptin concentration was moderately heritable (h2 = 0.34 +/- 0.13) and averaged 13.91 (SD = 5.74) ng/mL.	Hydrogen	53-55	leptin	Bos taurus	6-12
17548063-11	2007	These results are in accordance with the observation that DA-3-O-sulfate is more abundant in human blood than DA-4-O-sulfate and that in the crystal structure of SULT1A3 with dopamine bound to the active site, the 3-hydroxy group is aligned to form hydrogen bonds with catalytic residues of the enzyme.	Hydrogen	249-257	sulfotransferase family 1A member 3	Homo sapiens	162-169
17583332-2	2007	For a single encapsulated H2 and D2 molecule, accurate quantum five-dimensional calculations of the T-R energy levels and wave functions are performed that include explicitly, as fully coupled, all three translational and the two rotational degrees of freedom of the hydrogen molecule, while the cage is taken to be rigid.	Hydrogen	267-275	relaxin 2	Homo sapiens	26-35
17640135-1	2007	We carried out an electron spin resonance (ESR) study on hydrogen ion radicals produced by radiolysis of solid para-H(2).	Hydrogen	57-65	relaxin 2	Homo sapiens	116-120
17640135-8	2007	These results provide a conclusive evidence that H(2) (+)-core H(6) (+) ions are generated in irradiated solid hydrogens.	Hydrogen	111-120	relaxin 2	Homo sapiens	49-53
17380353-2	2007	The postulation is also made that binuclear divalent titanium (Ti(II)) and mononuclear silicon (Si(II)) species might serve as active sites for the H2 attachment reaction for hydridoalanates doped with Ti salts and hydridoborates doped with SiO2, respectively.	Hydrogen	148-150	elongin B	Homo sapiens	96-102
17449253-4	2007	Thus, a series of diverse P1 functional groups with different acidity and with possibilities to form a similar, or an even more powerful, hydrogen bond network as compared to the carboxylic acid were synthesized and incorporated into potential inhibitors of the NS3 protease.	Hydrogen	138-146	KRAS proto-oncogene, GTPase	Homo sapiens	262-265
17514339-3	2007	The cis-trans isomerization process was monitored by 1H-NMR and showed that 1b reverts back to cis-[Ru(DIP)2(MeOH)2][OTf]2 (1a) in methanol-d4 after 15 h at 55 degrees C or several days at room temperature.	Hydrogen	53-55	disco interacting protein 2 homolog A	Homo sapiens	103-108
17553121-4	2007	After extensive investigations, metabolite analysis and brain 1H-MRS suggested CRTR-D, which was confirmed by the detection of a known pathogenic mutation in the SLC6A8 gene (c.1631C&gt;T; p.Pro544Leu).	Hydrogen	62-64	solute carrier family 6 member 8	Homo sapiens	79-83
16950647-2	2007	These compounds present short intramolecular hydrogen bonds (SHB) between adjacent carboxyl groups.	Hydrogen	45-53	SH2 domain containing adaptor protein B	Homo sapiens	61-64
17552775-4	2007	With ammonium nitrate, containing nitrogen (spin-1) and hydrogen (spin-1/2), increased nitrogen signal and spin-lattice relaxation are demonstrated, using fields less than 120 G. The cross-relaxation rate is also measured and an overall signal/noise improvement by a factor of 2.3+/-0.1 is attained.	Hydrogen	56-64	spindlin 1	Homo sapiens	66-74
17439275-4	2007	In HOT microemulsions, the disparate strength of Na+...OH2 and H+...OH2 interactions results in a decrease in the resonance signal for the hydrogen atoms in the water molecules from delta approximately 8.6 ppm at W = 2 to delta approximately 4.9 ppm at W = 50.	Hydrogen	139-147	alcohol dehydrogenase iron containing 1	Homo sapiens	3-6
17237998-1	2007	D-xylose hydrogen breath test (H2BT) may be better parameter in screening for intestinal malabsorption in patients with celiac disease.	Hydrogen	9-17	H2B clustered histone 20, pseudogene	Homo sapiens	31-35
17279733-6	2007	In the conformer anti (syn) of lower (higher) energy, Ar is bound to the An ring opposite (adjacent) the amino-hydrogens.	Hydrogen	111-120	synemin	Homo sapiens	23-26
17257828-0	2007	Residues of the human nuclear vitamin D receptor that form hydrogen bonding interactions with the three hydroxyl groups of 1alpha,25-dihydroxyvitamin D3.	Hydrogen	59-67	vitamin D receptor	Homo sapiens	30-48
17256827-4	2007	The vinyl hydrogens of trans-2-butene are more acidic than the vinyl hydrogens of cis-2-butene by 4.5 kcal/mol; the acidities of ethene and the secondary vinyl hydrogen of propene are between those of the two butenes.	Hydrogen	69-78	suppressor of cytokine signaling 2	Homo sapiens	82-87
17263430-1	2007	This study deals with a spin system constituted of three nonequivalent protons, two of them originating from para-hydrogen (p-H(2)) after a hydrogenation reaction carried out in the earth magnetic field.	Hydrogen	114-122	spindlin 1	Homo sapiens	24-28
17249765-1	2007	High-resolution electron spin resonance (ESR) spectra of radical pairs of a hydrogen atom that coupled with a methyl radical (H...CH3, H...CHD2, D...CH2D, and D...CD3) were observed for X-ray irradiated solid argon containing selectively deuterium-labeled methanes, CH4, CH2D2, and CD4, at 4.2 K. The double-quartet 1H-hyperfine (hf) splittings of ca.	Hydrogen	76-84	chromodomain helicase DNA binding protein 2	Homo sapiens	139-143
17154238-6	2007	A very important factor seems to be the repulsive interaction between the O-1 and O-8 centers, which is modulated by formation of an OH-1...O-8 or OH-8...O1 hydrogen bond.	Hydrogen	157-165	immunoglobulin kappa variable 2D-40	Homo sapiens	74-85
17227023-5	2007	In-plane force titrations were found to have the sensitivity to detect ionic hydrogen bond formation between protonated and nonprotonated carboxylic acid groups in the proximity of the surface pK1/2, which generated a mean tensile differential surface stress of +1.2 +/- 0.3 mN/m at pH 6.0, corresponding to 1 pN attractive force between two adjacent MHA molecules.	Hydrogen	77-85	prokineticin 1	Homo sapiens	193-198
17228934-0	2007	The spin-orbit transition of atomic chlorine in solid H2, HD, and D2.	Hydrogen	54-56	spindlin 1	Homo sapiens	4-8
17228934-1	2007	Essential to understanding the reaction dynamics of spin-orbit (SO) excited atomic chlorine (2P1/2) with molecular hydrogen is experimental measurements of the SO splitting of Cl in the van der Waals region of the entrance channel to reaction.	Hydrogen	115-123	spindlin 1	Homo sapiens	52-56
17441143-3	2007	The formation of a hydrogen-bonding network between the triazolate moieties and sulfonate ions, bridged by water molecules, was found to play an important role in the spin-crossover event.	Hydrogen	19-27	spindlin 1	Homo sapiens	167-171
17441143-4	2007	The spin-transition temperature was tuned over a wide range by adding a small amount of 1-octanol, a scavenger for hydrogen-bonding interactions.	Hydrogen	115-123	spindlin 1	Homo sapiens	4-8
17441143-6	2007	Compared with nongelling references in aromatic solvents, the spin-crossover physical gels are characterized by their quick thermal response, which is due to a rapid restoration of the hydrogen-bonding network, possibly because of a dynamic structural ordering through an enhanced lipophilic interaction of the self-assembling components in hydrocarbon solvents.	Hydrogen	185-193	spindlin 1	Homo sapiens	62-66
17175208-9	2007	The sulfonated cysteines have two sulfite oxygens involved in intramonomer hydrogen bonds that bridge Cys10, the amino acid immediately before beta-strand A, to the amino acids immediately after the edge beta-strand D. Implications of the newly observed interactions in the inhibition of fibril formation are discussed in light of the recent structural models of TTR amyloid fibrils.	Hydrogen	75-83	transthyretin	Homo sapiens	363-366
17365001-1	2007	In human deoxyhemoglobin (deoxyHb), the hydrogen bond between Aspbeta99(G1) and Tyralpha42(C7), located in the alpha1beta2 interface, is crucial for the stability of the T structure.	Hydrogen	40-48	proline rich protein BstNI subfamily 3	Homo sapiens	62-74
17176054-0	2006	Dissecting the mechanism of Epac activation via hydrogen-deuterium exchange FT-IR and structural modeling.	Hydrogen	48-56	Rap guanine nucleotide exchange factor 3	Homo sapiens	28-32
17177435-1	2006	A porous hybrid inorganic/organic material, NaNi3(OH)(SIP)2 [SIP = 5-sulfoisophthalate][1], is shown to strongly bind molecular hydrogen at coordinatively unsaturated metal sites.	Hydrogen	128-136	gem nuclear organelle associated protein 6	Homo sapiens	54-59
17177457-0	2006	Asymmetric induction in hydrogen-mediated reductive aldol additions to alpha-amino aldehydes catalyzed by rhodium: selective formation of syn-stereotriads directed by intramolecular hydrogen-bonding.	Hydrogen	24-32	synemin	Homo sapiens	138-141
17177457-0	2006	Asymmetric induction in hydrogen-mediated reductive aldol additions to alpha-amino aldehydes catalyzed by rhodium: selective formation of syn-stereotriads directed by intramolecular hydrogen-bonding.	Hydrogen	182-190	synemin	Homo sapiens	138-141
17125375-6	2006	This indicates electron transfer from NAD* to Acr+-Mes to give Acr*-Mes, which undergoes the electron-transfer reduction of MVA2+-PtC, leading to the efficient hydrogen evolution.	Hydrogen	160-168	centrosomal protein 57	Homo sapiens	124-128
17109527-4	2006	Whereas the syn-syn preference of the 2-OMe-IPA branched repeat unit is stabilized entirely by intramolecular hydrogen-bonding interactions, this preference in the 2,6-pydic system is a consequence of both intramolecular hydrogen-bonding and dipole minimization effects.	Hydrogen	110-118	synemin	Homo sapiens	12-15
17109527-4	2006	Whereas the syn-syn preference of the 2-OMe-IPA branched repeat unit is stabilized entirely by intramolecular hydrogen-bonding interactions, this preference in the 2,6-pydic system is a consequence of both intramolecular hydrogen-bonding and dipole minimization effects.	Hydrogen	110-118	synemin	Homo sapiens	16-19
17109527-4	2006	Whereas the syn-syn preference of the 2-OMe-IPA branched repeat unit is stabilized entirely by intramolecular hydrogen-bonding interactions, this preference in the 2,6-pydic system is a consequence of both intramolecular hydrogen-bonding and dipole minimization effects.	Hydrogen	221-229	synemin	Homo sapiens	12-15
17109527-4	2006	Whereas the syn-syn preference of the 2-OMe-IPA branched repeat unit is stabilized entirely by intramolecular hydrogen-bonding interactions, this preference in the 2,6-pydic system is a consequence of both intramolecular hydrogen-bonding and dipole minimization effects.	Hydrogen	221-229	synemin	Homo sapiens	16-19
16972281-7	2006	The simulations show that the NS3 rearrangement occurs upon the NS2B binding, resulting in the stable D75-OD1...H51-NH hydrogen bonding.	Hydrogen	119-127	KRAS proto-oncogene, GTPase	Homo sapiens	30-33
17078708-1	2006	[Structure: see text] OH...OH hydrogen bond mediated scalar couplings have been observed in acyclic syn- and anti-1,3-diols using a 2D 1H COSYLR NMR experiment and quantified with an uncertainty of +/-0.02 Hz with a selective-excitation spin-echo NMR experiment.	Hydrogen	30-38	synemin	Homo sapiens	100-103
17078708-1	2006	[Structure: see text] OH...OH hydrogen bond mediated scalar couplings have been observed in acyclic syn- and anti-1,3-diols using a 2D 1H COSYLR NMR experiment and quantified with an uncertainty of +/-0.02 Hz with a selective-excitation spin-echo NMR experiment.	Hydrogen	135-137	synemin	Homo sapiens	100-103
17081013-5	2006	X-ray crystallography, 1H-1H NOESY spectroscopy, and computation demonstrate that minimization of allylic 1,3-strain and syn-pentane-like interactions work together in establishing this conformational preference.	Hydrogen	23-25	synemin	Homo sapiens	121-124
17081013-5	2006	X-ray crystallography, 1H-1H NOESY spectroscopy, and computation demonstrate that minimization of allylic 1,3-strain and syn-pentane-like interactions work together in establishing this conformational preference.	Hydrogen	26-28	synemin	Homo sapiens	121-124
17008929-4	2006	Our observations suggest that inter-helix hydrogen bonds can form during Sec61 translocon-assisted insertion and thus could be important for membrane protein assembly.	Hydrogen	42-50	SEC61 translocon subunit alpha 1	Homo sapiens	73-78
16872832-0	2006	Investigation of ligand interactions with human RXRalpha by hydrogen/deuterium exchange and mass spectrometry.	Hydrogen	60-68	retinoid X receptor alpha	Homo sapiens	48-56
16891616-8	2006	Pharmacophore analysis revealed that GIF shares common chemical properties (hydrogen bond acceptor, positive ionizable, and hydrophobic regions) with other subpicomolar-acting compounds known to inhibit NADPH oxidase: naloxone, dextromethorphan, and Gly-Gly-Phe.	Hydrogen	76-84	cobalamin binding intrinsic factor	Rattus norvegicus	37-40
16979657-0	2006	Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry.	Hydrogen	64-72	KIT ligand	Homo sapiens	31-34
16979657-4	2006	Here we have used hydrogen/deuterium exchange monitored by mass spectrometry to investigate the mode of action of Cks1 on SCF(Skp2).	Hydrogen	18-26	CDC28 protein kinase regulatory subunit 1B pseudogene 7	Homo sapiens	114-118
16979657-6	2006	We find that Skp2 interacts with a localised region of Cks1 but the interaction causes a global change in the hydrogen exchange behaviour of Cks1.	Hydrogen	110-118	CDC28 protein kinase regulatory subunit 1B pseudogene 7	Homo sapiens	141-145
16945328-9	2006	The 2D [1H-15N] HSQC was also employed to characterize structural changes during the reaction of hMT3 with varying mounts of nitric oxide.	Hydrogen	8-10	metallothionein 3	Homo sapiens	97-101
17029377-9	2006	The proximity of the thiophene fragment to the metal ion induced direct scalar couplings between the spin-active nucleus of the metal (111/113Cd) and the adjacent 1H nucleus (J(CdH) = 8.97 Hz).	Hydrogen	163-165	choline dehydrogenase	Homo sapiens	177-180
17004712-14	2006	Taken together, these results support the hypothesis that it is the carboxamide oxygen of the C-3 substituent of 1 that engages in a hydrogen bond with K3.28(192) in WT CB1.	Hydrogen	133-141	complement C3	Homo sapiens	94-97
16927179-8	2006	Hydrogen bonding and surface interaction between metal ions of Neusilin US2 and indomethacin can explain changes in the FTIR spectra.	Hydrogen	0-8	usherin	Homo sapiens	72-75
16964980-0	2006	Hydrogen bonds between the alpha and beta subunits of the F1-ATPase allow communication between the catalytic site and the interface of the beta catch loop and the gamma subunit.	Hydrogen	0-8	ATPase	Escherichia coli	61-67
16964980-2	2006	Loss of the ability to form the hydrogen bonds involving alphaS337, betaD301, and alphaD335 lowered the k(cat) of ATPase and decreased its susceptibility to Mg(2+)-ADP-AlF(n) inhibition, while mutations that maintain or strengthen these bonds increased the susceptibility to Mg(2+)-ADP-AlF(n) inhibition and lowered the k(cat) of ATPase.	Hydrogen	32-40	ATPase	Escherichia coli	114-120
16964980-2	2006	Loss of the ability to form the hydrogen bonds involving alphaS337, betaD301, and alphaD335 lowered the k(cat) of ATPase and decreased its susceptibility to Mg(2+)-ADP-AlF(n) inhibition, while mutations that maintain or strengthen these bonds increased the susceptibility to Mg(2+)-ADP-AlF(n) inhibition and lowered the k(cat) of ATPase.	Hydrogen	32-40	ATPase	Escherichia coli	330-336
16866490-2	2006	Pd(PEt3)2(OTf)2, acting as an in situ source of Pd(PEt3)2, reacts with an alkyne and hydrogen via phosphine loss to form the detectable hydride-containing species Pd(PEt3)2(H)(CHPhCH2Ph), cis- and trans-Pd(PEt3)2(H)(CPh=CHPh), and Pd2(PEt3)3(H)(CHPhCH2Ph)2+, which map onto the reaction scheme predicted by density functional theory.	Hydrogen	85-93	POU class 2 homeobox 2	Homo sapiens	10-15
16866878-8	2006	Instead, water-mediated hydrogen bonding interactions were observed in Rad.	Hydrogen	24-32	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	71-74
16905207-5	2006	RESULTS: The fraction of gammaH2AX remaining 24h after X-irradiation relative to peak levels 1h after exposure was correlated with radiosensitivity (SF2) for 18 human tumor cell lines.	Hydrogen	93-95	serine and arginine rich splicing factor 1	Homo sapiens	149-152
16839174-2	2006	Three-fold methyllithium addition to 2,4,6-trimethoxybenzene-1,3,5-tricarbaldehyde gives the anti,syn triol exclusively (by 1H NMR); addition of HMPA to the reaction or replacement of the substrate"s methoxy groups with ethyl groups affords a statistical 3:1 (anti,syn:syn,syn) diastereomeric product ratio.	Hydrogen	124-126	synemin	Homo sapiens	98-101
16530227-9	2006	1H-MRSI showed N-acetylaspartate to creatine ratio (NAA/Cr) decreases in the central brain VOI in all TTR-FAP patients (p < 0.005).	Hydrogen	0-2	transthyretin	Homo sapiens	102-105
16530227-11	2006	CONCLUSIONS: 1H-MRSI findings suggest that diffuse metabolic changes, probably related to axonal damage, are present in brains of TTR-FAP patients even when they have no or minimal clinical and MRI signs of CNS involvement.	Hydrogen	13-15	transthyretin	Homo sapiens	130-133
16794122-3	2006	CONCLUSION: The fat fraction calculated with opposed-phase imaging (FF(OPI)) and that calculated with 1H MRS (FF(MRS)) correlated well with the known fat fractions of the phantoms (FF(P)): r = 0.99 for FF(OPI); p &lt; 0.0001 and r = 0.96-0.98 for FF(MRS); p &lt; 0.001, for observers 2 and 3, respectively.	Hydrogen	102-104	MROS	Homo sapiens	110-117
21783678-4	2006	In cells exposed to 4muM CdCl(2) for up to 1h, the level of phosphorylated JNK increased by 15min and peaked at 30min exposure time, as determined by a phospho-specific anti-JNK antibody, while the total amount of JNK protein did not change.	Hydrogen	43-45	mitogen-activated protein kinase 8	Mus musculus	75-78
21783678-4	2006	In cells exposed to 4muM CdCl(2) for up to 1h, the level of phosphorylated JNK increased by 15min and peaked at 30min exposure time, as determined by a phospho-specific anti-JNK antibody, while the total amount of JNK protein did not change.	Hydrogen	43-45	mitogen-activated protein kinase 8	Mus musculus	174-177
21783678-4	2006	In cells exposed to 4muM CdCl(2) for up to 1h, the level of phosphorylated JNK increased by 15min and peaked at 30min exposure time, as determined by a phospho-specific anti-JNK antibody, while the total amount of JNK protein did not change.	Hydrogen	43-45	mitogen-activated protein kinase 8	Mus musculus	174-177
16787097-2	2006	Its binding to hCA II is similar to that of other benzesulfonamides, with the ionized sulfonamide coordinated to the Zn2+ ion within the enzyme active site, and also participating in a network of hydrogen bonds with residues Thr199 and Glu106.	Hydrogen	196-204	carbonic anhydrase 2	Homo sapiens	15-21
16671666-1	2006	The possible competition of Z/E versus hydrogen-shift isomerization in (E)-5-phenyl-3-penten-2-one (E-1) and (E)-5-phenyl-4-penten-2-one (E-2) was studied, both experimentally and theoretically.	Hydrogen	39-47	cystatin 12, pseudogene	Homo sapiens	138-141
16734752-8	2006	Two-thirds of filtered sodium and water are absorbed in the renal proximal tubule, a mechanism that intimately involves the apical sodium/hydrogen ion exchanger, NHE3.	Hydrogen	138-146	solute carrier family 9 member A3	Homo sapiens	162-166
16641296-6	2006	The native structure of the protease reveals strong hydrogen bond interactions between His 30 and Glu 54, in the favorable syn configuration, indicating a role of Glu 54 during proteolysis.	Hydrogen	52-60	synemin	Homo sapiens	123-126
16674228-2	2006	The primary focus of our calculations is on the H2 bond length dependence of the dipole moment, which determines the intensities of both the collision-induced H2 upsilon = 1 &lt;-- 0 fundamental band in gaseous Ar-H2 mixtures and the dopant-induced H2 upsilon = 1 &lt;-- 0 absorption feature in Ar-doped solid H2 matrices.	Hydrogen	48-50	ADP-ribosylhydrolase like 1	Homo sapiens	211-216
16674228-2	2006	The primary focus of our calculations is on the H2 bond length dependence of the dipole moment, which determines the intensities of both the collision-induced H2 upsilon = 1 &lt;-- 0 fundamental band in gaseous Ar-H2 mixtures and the dopant-induced H2 upsilon = 1 &lt;-- 0 absorption feature in Ar-doped solid H2 matrices.	Hydrogen	159-161	ADP-ribosylhydrolase like 1	Homo sapiens	211-216
16674228-2	2006	The primary focus of our calculations is on the H2 bond length dependence of the dipole moment, which determines the intensities of both the collision-induced H2 upsilon = 1 &lt;-- 0 fundamental band in gaseous Ar-H2 mixtures and the dopant-induced H2 upsilon = 1 &lt;-- 0 absorption feature in Ar-doped solid H2 matrices.	Hydrogen	159-161	ADP-ribosylhydrolase like 1	Homo sapiens	211-216
16674228-2	2006	The primary focus of our calculations is on the H2 bond length dependence of the dipole moment, which determines the intensities of both the collision-induced H2 upsilon = 1 &lt;-- 0 fundamental band in gaseous Ar-H2 mixtures and the dopant-induced H2 upsilon = 1 &lt;-- 0 absorption feature in Ar-doped solid H2 matrices.	Hydrogen	159-161	ADP-ribosylhydrolase like 1	Homo sapiens	211-216
16297962-8	2006	BDE-206, BDE-207, BDE-208 and Cl-BDE-208 were characterized by 1H NMR, 13C NMR, electron ionization mass spectra and by their melting points.	Hydrogen	63-65	homeobox D13	Homo sapiens	0-3
16515860-0	2006	Low-resolution 1H spin-spin relaxation of n-decane/water emulsions stabilized by beta-casein.	Hydrogen	15-17	spindlin 1	Homo sapiens	18-22
16515860-0	2006	Low-resolution 1H spin-spin relaxation of n-decane/water emulsions stabilized by beta-casein.	Hydrogen	15-17	spindlin 1	Homo sapiens	23-27
16522090-6	2006	We report results for the majority of sites in the 56-residue beta1 immunoglobulin binding domain of protein G (GB1), using 3D experiments at 600 MHz 1H frequency.	Hydrogen	150-152	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	112-115
16522119-1	2006	The tautomeric equilibrium in a Schiff base, N-(3,5-dibromosalicylidene)-methylamine 1, a model for the hydrogen bonded structure of the cofactor pyridoxal-5"-phosphate PLP which is located in the active site of the enzyme, was measured by means of 1H and 15N NMR and deuterium isotope effects on 15N chemical shifts at variable temperature and in different organic solvents.	Hydrogen	104-112	proteolipid protein 1	Homo sapiens	169-172
16522119-1	2006	The tautomeric equilibrium in a Schiff base, N-(3,5-dibromosalicylidene)-methylamine 1, a model for the hydrogen bonded structure of the cofactor pyridoxal-5"-phosphate PLP which is located in the active site of the enzyme, was measured by means of 1H and 15N NMR and deuterium isotope effects on 15N chemical shifts at variable temperature and in different organic solvents.	Hydrogen	249-251	proteolipid protein 1	Homo sapiens	169-172
16384584-5	2006	Here, we determine the free energy of dimerization of wild-type and mutant FGFR3 TM domain in lipid bilayers using Forster resonance energy transfer, and we show that hydrogen bonding between Glu391 and the adjacent helix in the dimer is a feasible mechanism for dimer stabilization.	Hydrogen	167-175	fibroblast growth factor receptor 3	Homo sapiens	75-80
16475054-1	2006	Using in vivo proton magnetic resonance spectroscopy (1H-MRS), a new peak resonating at 2.13 ppm post-exercise has been attributed in the literature to the acetyl groups of acetylcarnitine.	Hydrogen	54-56	MROS	Homo sapiens	57-60
16475054-9	2006	1H-MRS may be used for the noninvasive study of muscle metabolism during exercise and recovery and may have special applications for studying the generation and transport of acetyl compounds, including acetylcarnitine.	Hydrogen	0-2	MROS	Homo sapiens	3-6
16427351-1	2006	The vibrational characteristics (vibrational frequencies, infrared intensities and Raman activities) for the hydrogen-bonded system of Vitamin C (L-ascorbic acid) with five water molecules have been predicted using ab initio SCF/6-31G(d,p) calculations and DFT (BLYP) calculations with 6-31G(d,p) and 6-31++G(d,p) basis sets.	Hydrogen	109-117	KIT ligand	Homo sapiens	225-228
16411748-4	2006	In this study, on the basis of our first generation nuclear magnetic resonance (NMR) structure of the ternary complex of human I-BABP with GCA and GCDA, we introduced single-residue mutations at certain key positions in the binding pocket that might disrupt a hydrogen-bonding network, a likely way of energetic communication between the two sites.	Hydrogen	260-268	fatty acid binding protein 6	Homo sapiens	127-133
16422608-1	2006	The infrared spectrum of the complex between o-H2 and H2O, D2O, or HDO, isolated in a matrix of solid p-H2, has been studied between 20 and 4500 cm(-1).	Hydrogen	47-49	polyhomeotic homolog 2	Homo sapiens	102-106
16392851-9	2006	H atoms are transformed via reaction 4, H+(CHO)2--&gt;H2+HCO+CO, into additional HCO radicals.	Hydrogen	54-56	EBP cholestenol delta-isomerase	Homo sapiens	43-48
16411186-12	2006	O hydrogen bond with the carbonyl oxygen of the Boc group.	Hydrogen	2-10	BOC cell adhesion associated, oncogene regulated	Homo sapiens	48-51
16633989-8	2006	Quantitative polymerase chain reaction (PCR) and Western blot analysis reveal that in diabetic rats compared with controls, mRNA and protein abundance was higher for type 3 sodium/hydrogen exchanger (NHE3) in proximal tubule and ascending limbs of Henle"s loop, and higher for bumetanide-sensitive sodium-potassium-2 chloride cotransporter (NKCC2) in ascending limbs of Henle"s loop.	Hydrogen	180-188	solute carrier family 12 member 1	Rattus norvegicus	341-346
16855860-0	2006	1H, 13C, and 15N peak assignments and secondary structure of human macrophage metalloelastase (MMP-12) in its inhibitor-free state.	Hydrogen	0-2	matrix metallopeptidase 12	Homo sapiens	67-101
16858624-0	2006	1H, 15N, 13C assignments for the activated form of the small Rho-GTPase Rac1.	Hydrogen	0-2	Rac family small GTPase 1	Homo sapiens	72-76
16214338-4	2005	The X-ray crystallographic structure of the hCA II-l-His adduct showed the activator to be anchored at the entrance of the active site cavity, participating in an extended network of hydrogen bonds with the amino acid residues His64, Asn67, and Gln92 and, with three water molecules connecting it to the zinc-bound water.	Hydrogen	183-191	carbonic anhydrase 2	Homo sapiens	44-50
16190722-11	2005	After reduction at 773 K in hydrogen the Ni/CNF-O contained metallic nickel particles of 8 nm homogeneously distributed over the fibers.	Hydrogen	28-36	NPHS1 adhesion molecule, nephrin	Homo sapiens	44-47
16115741-8	2005	The 1H NMR data supported the hypothesis that such complexation was a consequence of preferential pi-pi orbital interactions between the phenyl groups of tamoxifen and the multiple double bonds of GLA.	Hydrogen	4-6	galactosidase alpha	Homo sapiens	197-200
16277340-9	2005	Determination of the absolute configurations of the syn and anti isomers of adduct 7b showed that the hydrogen atom abstraction step was significantly more stereoselective than the radical conjugate addition step.	Hydrogen	102-110	synemin	Homo sapiens	52-55
16106293-7	2005	Together the results reveal that for the "natural" C-2 stereochemistry of 2S-naringenin, C-3 hydroxylation predominates (&gt;9 : 1) over desaturation, probably due to the inaccessibility of the C-2 hydrogen to the iron centre.	Hydrogen	198-206	complement C3	Homo sapiens	89-92
16086027-2	2005	The CYP2A6 structure shows a compact, hydrophobic active site with one hydrogen bond donor, Asn297, that orients coumarin for regioselective oxidation.	Hydrogen	71-79	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	4-10
16229588-2	2005	Given that the C=O and OH groups in acetic acid provide the predominant hydrogen-bonding interactions with water, six stable conformer structures have been found each for the monohydrate and syn-dihydrate.	Hydrogen	72-80	synemin	Homo sapiens	191-194
16097805-18	2005	Similarly, decomposition of P9 led to the formation of P4-2, P6, and nucleoside products resulting from opening of the oxirane ring by dihydrogen phosphate ion, water, or chloride ion.	Hydrogen	135-145	erythrocyte membrane protein band 4.2	Homo sapiens	55-59
16055723-6	2005	These observations suggest that both Poleta and Polkappa rely on W-C hydrogen bonding for localizing the nascent base pair in the active site for the polymerization reaction to occur, thus overcoming these enzymes" low geometric selectivity.	Hydrogen	69-77	DNA polymerase lambda	Homo sapiens	48-56
16852651-5	2005	Hydrogen TPR revealed that our Ni-MCM-41 samples have high stability against reduction; however, compared to Co-MCM-41, the Ni-MCM-41 has a lower reduction temperature, and both the H2-TPR and in situ XANES TPR reveal that the reducibility of nickel is not clearly correlated with the pore radius of curvature, as in the case of Co-MCM-41.	Hydrogen	0-8	translocated promoter region, nuclear basket protein	Homo sapiens	9-12
15981994-7	2005	Crystals of factor Xa and PD0313052 demonstrated hydrogen bonding contacts within the S1-S4 pocket at residues Ser195, Asp189, Gly219, and Gly216, as well as interactions with aromatic residues within the S4 pocket.	Hydrogen	49-57	coagulation factor X	Homo sapiens	12-21
16022502-7	2005	Structural refinement based upon a total of 394 NOE-derived distance restraints and 151 torsion angle restraints yielded a structure in which the modified deoxyinosine was in the syn conformation about the glycosyl bond, with a glycosyl bond angle of 83 degrees , and T17, the complementary nucleotide, was stacked into the helix but not hydrogen bonded with the adducted inosine.	Hydrogen	338-346	synemin	Homo sapiens	179-182
15914019-0	2005	Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study.	Hydrogen	116-124	spleen associated tyrosine kinase	Homo sapiens	70-73
15924281-1	2005	The 1H and 13C NMR spectra of six 5-substituted 2-azabicyclo[2.2.2]octane derivatives were fully assigned by COSY and HSQC experiments.	Hydrogen	4-6	SIX homeobox 5	Homo sapiens	30-35
15961501-2	2005	Accurate prediction and assembly of protein beta-sheets, however, remains challenging because protein beta-sheets require formation of hydrogen bonds between linearly distant residues.	Hydrogen	135-143	prolyl 3-hydroxylase 3	Homo sapiens	36-48
15961501-2	2005	Accurate prediction and assembly of protein beta-sheets, however, remains challenging because protein beta-sheets require formation of hydrogen bonds between linearly distant residues.	Hydrogen	135-143	prolyl 3-hydroxylase 3	Homo sapiens	94-106
15842171-0	2005	Dynamics of the native and the ligand-bound structures of eosinophil cationic protein: network of hydrogen bonds at the catalytic site.	Hydrogen	98-106	ribonuclease A family member 3	Homo sapiens	58-85
15863043-2	2005	Crystal structures of all five compounds show short intramolecular asymmetric hydrogen bonds (SHB) between adjacent carboxyl groups with O...O distance average of 2.40 A.	Hydrogen	78-86	SH2 domain containing adaptor protein B	Homo sapiens	94-97
15802131-0	2005	Fluorescence imaging of the activity of glucose oxidase using a hydrogen-peroxide-sensitive europium probe.	Hydrogen	64-72	hydroxyacid oxidase 1	Homo sapiens	40-55
15877345-0	2005	Conformational study and hydrogen bonds detection on elastin-related polypeptides using X-ray photoelectron spectroscopy.	Hydrogen	25-33	elastin	Homo sapiens	53-60
15803207-5	2005	It is also suggested that for MAAP, which has a stronger hydrogen-bond as compared to AAP, an intramolecular hydrogen-bonding induced deactivation is involved in the dissipation of the S1 state.	Hydrogen	57-65	serpin family F member 2	Homo sapiens	31-34
15803207-5	2005	It is also suggested that for MAAP, which has a stronger hydrogen-bond as compared to AAP, an intramolecular hydrogen-bonding induced deactivation is involved in the dissipation of the S1 state.	Hydrogen	109-117	serpin family F member 2	Homo sapiens	31-34
15783171-3	2005	Isotopic perturbation of resonance (IPR) experiments, conducted on several isotopomers of (i-PrCp)Re(CO)2(1-pentane), showed a large shielding of the 1H NMR chemical shift of the proton in a bound CHD2 moiety (delta -3.62) and CH2D (delta -2.64) compared with that of a bound CH3 moiety (delta -1.99).	Hydrogen	150-152	chromodomain helicase DNA binding protein 2	Homo sapiens	197-201
15708008-4	2005	The SSF-TRPM2 protein still maintained H2(O2)-induced Ca2+ influx activity.	Hydrogen	39-41	transient receptor potential cation channel subfamily M member 2	Homo sapiens	8-13
15736931-2	2005	Comparison of the crystal structures of UDP-Gal- and UDP-Glc-bound beta4Gal-T1 reveals that the O4 hydroxyl group in both Gal and Glc moieties forms a hydrogen bond with the side chain carboxylate group of Glu317.	Hydrogen	151-159	beta-1,4-galactosyltransferase 1	Bos taurus	67-78
16833474-0	2005	A quantum wave packet dynamical study of the electronic and spin-orbit coupling effects on the resonances in Cl(2P) + H2 scattering.	Hydrogen	118-120	spindlin 1	Homo sapiens	60-64
15803399-0	2005	1H, 13C, and 15N resonance assignments of SAP18.	Hydrogen	0-2	Sin3A associated protein 18	Homo sapiens	42-47
15803400-0	2005	1H, 13C, and 15N assignments of MMP-12, a key protease implicated in lung tissue remodeling.	Hydrogen	0-2	matrix metallopeptidase 12	Homo sapiens	32-38
15710410-1	2005	In tritium-hydrogen exchange experiments, the large GroEL substrate Rubisco was unfolded and exchanged in urea/acid/tritiated water, then diluted into either protic buffer or protic buffer containing GroEL.	Hydrogen	11-19	heat shock protein family D (Hsp60) member 1	Homo sapiens	52-57
15588107-8	2005	In particular, when the charge of 2"-deoxyribonucleotide anions is completely compensated by protons, the syn conformations have been found to be the global minima due to stabilization provided by intramolecular hydrogen bonds.	Hydrogen	212-220	synemin	Homo sapiens	106-109
15772759-0	2005	1H, 13C and 15N resonance assignments and secondary structure of murine angiogenin 4.	Hydrogen	0-2	angiogenin, ribonuclease A family, member 4	Mus musculus	72-84
15609375-7	2005	On complex formation with adrenaline, the syn-conformer becomes dominant due to an intramolecular dipole-reversal effect in addition to multipoint hydrogen bonding.	Hydrogen	147-155	synemin	Homo sapiens	42-45
15698069-0	2005	Single-spin asymmetries in semi-inclusive deep-inelastic scattering on a transversely polarized hydrogen target.	Hydrogen	96-104	spindlin 1	Homo sapiens	7-11
21783459-6	2005	A 1h exposure to 300nM TBT followed by 24h in TBT-free media decreased cytotoxic function by 80%, and expression of CD16 by 16%.	Hydrogen	2-4	Fc gamma receptor IIIa	Homo sapiens	116-120
15608125-3	2005	To investigate the energetic contribution of this hydrogen bond network to ligand binding, we have applied isothermal titration calorimetry to measure the binding thermodynamics using several MUP mutants and ligand analogs.	Hydrogen	50-58	major urinary protein 21	Mus musculus	192-195
15456757-7	2004	Moreover, unlike Ec-Lon, Mj-Lon has a buried cavity in the region of the active site containing three water molecules, one of which is hydrogen-bonded to catalytic Ser-550.	Hydrogen	135-143	putative ATP-dependent Lon protease	Escherichia coli	28-31
15561147-2	2004	The ability of dCK to degrade 2"-deoxyribonucleosides to free nucleobases and 2-deoxy-alpha-d-ribofuranose-1-phosphate was demonstrated by 1H-31P correlation spectroscopy and by isotope enzyme kinetic methods.	Hydrogen	139-141	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	15-18
15522777-5	2004	The refined Ym1 structure at 1.31A resolution clearly displays a water cluster forming an extensive hydrogen bond network with the "active-site" residues.	Hydrogen	100-108	chitinase-like 3	Mus musculus	12-15
15308183-5	2004	The dependence of TPD on BDE thickness was influenced by the BDE material used as indicated by the sharply peaked TPD versus BDE thickness curves for materials with hydrogen compared to the broader curves obtained for those without hydrogen.	Hydrogen	165-173	homeobox D13	Homo sapiens	25-28
15308183-5	2004	The dependence of TPD on BDE thickness was influenced by the BDE material used as indicated by the sharply peaked TPD versus BDE thickness curves for materials with hydrogen compared to the broader curves obtained for those without hydrogen.	Hydrogen	165-173	homeobox D13	Homo sapiens	61-64
15308183-5	2004	The dependence of TPD on BDE thickness was influenced by the BDE material used as indicated by the sharply peaked TPD versus BDE thickness curves for materials with hydrogen compared to the broader curves obtained for those without hydrogen.	Hydrogen	165-173	homeobox D13	Homo sapiens	61-64
15308183-5	2004	The dependence of TPD on BDE thickness was influenced by the BDE material used as indicated by the sharply peaked TPD versus BDE thickness curves for materials with hydrogen compared to the broader curves obtained for those without hydrogen.	Hydrogen	232-240	homeobox D13	Homo sapiens	25-28
15308183-5	2004	The dependence of TPD on BDE thickness was influenced by the BDE material used as indicated by the sharply peaked TPD versus BDE thickness curves for materials with hydrogen compared to the broader curves obtained for those without hydrogen.	Hydrogen	232-240	homeobox D13	Homo sapiens	61-64
15308183-5	2004	The dependence of TPD on BDE thickness was influenced by the BDE material used as indicated by the sharply peaked TPD versus BDE thickness curves for materials with hydrogen compared to the broader curves obtained for those without hydrogen.	Hydrogen	232-240	homeobox D13	Homo sapiens	61-64
15308183-6	2004	The BDE thickness required to achieve TPD(max) (BDE(TPD(max))) were also found to be thinner for materials with hydrogen.	Hydrogen	112-120	homeobox D13	Homo sapiens	4-7
15308183-6	2004	The BDE thickness required to achieve TPD(max) (BDE(TPD(max))) were also found to be thinner for materials with hydrogen.	Hydrogen	112-120	homeobox D13	Homo sapiens	48-51
15541293-4	2004	MAN I as well as MAN II showed highest activity at pH 4.5 and 60 degrees C and were stable in the pH range 4.5-8.5 and up to 55 degrees C. In accordance with the ability of the enzymes to catalyze transglycosylation reactions, 1H NMR spectroscopy of reaction products generated from mannopentaitol confirmed the retaining character of both enzymes.	Hydrogen	227-229	mannosidase alpha class 2A member 1	Homo sapiens	17-23
15465335-6	2004	From observations of the SAR and modeling studies, we suggested the possibilities that the formation of hydrogen bond with the oxide anion in the "cation hole" and the affinity of cationic pyridine ring to S4 subsite were responsible for increase in anti-fXa activity.	Hydrogen	104-112	coagulation factor X	Homo sapiens	255-258
15666848-9	2004	Our structural homology model of human 3beta-HSD predicts that Gln105 on one enzyme subunit hydrogen-binds to His156 on the other subunit of the enzyme homodimer.	Hydrogen	92-100	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	39-48
15380220-1	2004	We have designed, synthesized, and evaluated the factor Xa inhibitory activities of p-amidinophenyl-sulfones, amines, and alcohols intended to take advantage of the polarity and hydrogen-bonding potential of the oxyanion hole region of the S1 specificity pocket.	Hydrogen	178-186	coagulation factor X	Homo sapiens	49-58
15175424-9	2004	The 7520C &gt; G SNP was previously known to be present in both CYP2A13(*)1H and (*)3 alleles.	Hydrogen	74-76	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	64-71
15273299-7	2004	The general-base-catalyzed hydroxyl proton abstraction from substrate concerted with hydride transfer to the C5 of PQQ is assisted by hydrogen-bonding to the C5=O by Wat1 and Arg 324 in MDH and by Wat89 and Arg 228 in sGDH.	Hydrogen	134-142	malate dehydrogenase 2	Homo sapiens	186-189
15236558-5	2004	These results indicate that the NH...O hydrogen bonding between the amide NH and the oxygen atom of the carboxylate contributes to strong Ca(II) binding and prevents the dissociation of the calcium-carboxylate bond.	Hydrogen	39-47	carbonic anhydrase 2	Homo sapiens	138-144
15201541-1	2004	OBJECTIVES: The objectives of this study were to identify polymorphic variants within the gene coding for the sodium/hydrogen exchanger type 3 (NHE3) and to examine their relationship with hypertension and biochemical indices of sodium balance.	Hydrogen	117-125	solute carrier family 9 member A3	Homo sapiens	144-148
15201541-9	2004	CONCLUSIONS: These results suggest a high degree of structural conservation of the NHE3 gene; however, the lack of association between these polymorphisms and blood pressure status does not necessarily eliminate the participation of this important sodium/hydrogen exchanger in the pathophysiology of essential hypertension, as we cannot exclude the existence of functionally important genetic variants in other sequences within the NEH3 gene.	Hydrogen	255-263	solute carrier family 9 member A3	Homo sapiens	83-87
15210941-1	2004	Temperature-dependent hydrogen-deuterium (H/D) exchange of the thermophilic alcohol dehydrogenase (htADH) has been studied by using liquid chromatography-coupled mass spectrometry.	Hydrogen	22-30	aldo-keto reductase family 1 member A1	Homo sapiens	76-97
15198605-5	2004	For substrates with C-H bond dissociation energies (BDEs) &gt; 92 kcal/mol, the activation energy for hydrogen abstraction decreases with decreasing BDE in accord with the Evans-Polanyi equation, with alpha approximately 0.3.	Hydrogen	102-110	homeobox D13	Homo sapiens	52-55
15033987-7	2004	Furthermore, co-immunoprecipitation of RyR1 with 33 various mutants for the 9 positions produced by introducing different size, charge, and hydrophobicity revealed that an integration of the hydrogen bonds by the irreplaceable Gln-3 and the hydrophobic interactions by the residues Arg-18 and Met-49 could be a possible mechanism for the binding of FKBP12 to RyR1.	Hydrogen	191-199	peptidyl-prolyl cis-trans isomerase FKBP1A	Oryctolagus cuniculus	349-355
15095336-5	2004	The Na(+)-hydrogen exchanger NHE2 was expressed at mRNA and protein levels in the caput but only marginally detectable if at all in the distal epididymis.	Hydrogen	10-18	solute carrier family 9 (sodium/hydrogen exchanger), member 2	Mus musculus	29-33
15066441-5	2004	These water molecules in the interface perform definite "tasks" contributing to the binding energy: hydrogen bond bridges between MHC and peptide and filling empty spaces in the groove which enhance affinity without contributing to epitope specificity.	Hydrogen	100-108	major histocompatibility complex, class I, C	Homo sapiens	130-133
15049691-0	2004	A linear correlation between the energetics of allosteric communication and protein flexibility in the Escherichia coli cyclic AMP receptor protein revealed by mutation-induced changes in compressibility and amide hydrogen-deuterium exchange.	Hydrogen	214-222	catabolite gene activator protein	Escherichia coli	120-147
14990306-1	2004	As a model for interactions present in the active site of orotidine-5"-monophosphate decarboxylase (ODCase), the effect of hydrogen bonds to the carbonyl groups (O-2 and O-4) of orotic acid and its decarboxylation product was probed with ab initio calculations.	Hydrogen	123-131	immunoglobulin kappa variable 1D-39	Homo sapiens	162-173
14769057-3	2004	The conformational rigidity imparted to the fold by the presence of hydrogen-bonded, C5, C7, C10 and C13 structures in the loop regions, multiple aromatic--aromatic interactions at the protein interior and on the surface, in addition to salt-links and hydrogen-bonds are primarily the major factors, responsible for the increased stability of protein.	Hydrogen	68-76	homeobox C13	Homo sapiens	101-104
14769057-3	2004	The conformational rigidity imparted to the fold by the presence of hydrogen-bonded, C5, C7, C10 and C13 structures in the loop regions, multiple aromatic--aromatic interactions at the protein interior and on the surface, in addition to salt-links and hydrogen-bonds are primarily the major factors, responsible for the increased stability of protein.	Hydrogen	252-260	homeobox C13	Homo sapiens	101-104
15094473-1	2004	Calcium influx via low-voltage activated alpha(1H) (Ca(v)3.2) T-currents participates in the morphological and electrical differentiation of neuroblastoma NG108-15 cells.	Hydrogen	47-49	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	52-60
15070205-9	2004	Thicker BDE(TPDmax), obtained mostly for BDE materials without hydrogen, significantly reduced the dose rates within the phantom.	Hydrogen	63-71	homeobox D13	Homo sapiens	8-19
14990469-0	2004	Temperature-dependent conformational transitions and hydrogen-bond dynamics of the elastin-like octapeptide GVG(VPGVG): a molecular-dynamics study.	Hydrogen	53-61	elastin	Homo sapiens	83-90
15268533-0	2004	Tunneling chemical reactions in solid parahydrogen: direct measurement of the rate constants of R + H2 --&gt; RH + H (R = CD3,CD2H,CDH2,CH3) at 5 K. Tunneling chemical reactions between deuterated methyl radicals and the hydrogen molecule in a parahydrogen crystal have been studied by Fourier transform infrared spectroscopy.	Hydrogen	42-50	cadherin 2	Homo sapiens	131-135
15268533-1	2004	The tunneling rates of the reactions R + H2 --&gt; RH + H (R = CD3,CD2H,CDH2) in the vibrational ground state were determined directly from the temporal change in the intensity of the rovibrational absorption bands of the reactants and products in each reaction in solid parahydrogen observed at 5 K. The tunneling rate of each reaction was found to differ definitely depending upon the degree of deuteration in the methyl radicals.	Hydrogen	41-43	cadherin 2	Homo sapiens	72-76
14744134-0	2004	Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry.	Hydrogen	111-119	retinoid X receptor alpha	Homo sapiens	67-86
14726150-6	2004	Furthermore, UDP-glucuronosyltransferase (UGT), generally considered to be an integral membrane protein anchored in the endoplasmatic reticulum, was recovered in both the cytosolic (i.e., the supernatant after centrifugation at 50,000 x g(av) for 1h) and the microsomal fraction of the porcine corpus luteum, even upon further centrifugation of the former.	Hydrogen	247-249	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	13-40
14726150-6	2004	Furthermore, UDP-glucuronosyltransferase (UGT), generally considered to be an integral membrane protein anchored in the endoplasmatic reticulum, was recovered in both the cytosolic (i.e., the supernatant after centrifugation at 50,000 x g(av) for 1h) and the microsomal fraction of the porcine corpus luteum, even upon further centrifugation of the former.	Hydrogen	247-249	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	42-45
14695346-5	2004	X-ray crystallography of normal and amyloidogenic human TTR Val30Met in type I FAP showed that the -SH side chain of cysteine at position 10 (Cys10) forms a hydrogen bond with Gly57 in normal TTR but not in TTR Val30Met.	Hydrogen	157-165	transthyretin	Homo sapiens	56-59
14739643-0	2004	1H, 13C and 15N resonance assignments for the N-cadherin prodomain.	Hydrogen	0-2	cadherin 2	Homo sapiens	46-56
14636604-3	2003	These observations suggest that inter-helix hydrogen bonds can form within the context of the Sec61 translocon in the endoplasmic reticulum, implying that hydrophobic segments in a nascent polypeptide chain in transit through the Sec61 channel have immediate access to a non-aqueous subcompartment within the translocon.	Hydrogen	44-52	SEC61 translocon subunit alpha 1	Homo sapiens	94-99
14636604-3	2003	These observations suggest that inter-helix hydrogen bonds can form within the context of the Sec61 translocon in the endoplasmic reticulum, implying that hydrophobic segments in a nascent polypeptide chain in transit through the Sec61 channel have immediate access to a non-aqueous subcompartment within the translocon.	Hydrogen	44-52	SEC61 translocon subunit alpha 1	Homo sapiens	230-235
14640599-6	2003	Measurements by laser diffraction and [1H]NMR showed that suppression of LePG or LeExp1 accumulation altered the size distribution of insoluble particles and modified their surface properties.	Hydrogen	39-41	expansin	Solanum lycopersicum	81-87
14622030-6	2003	In molecules consisting of proton donor and acceptor units linked by a single bond, syn-anti rotamerization caused by hydrogen bonding is observed.	Hydrogen	118-126	synemin	Homo sapiens	84-87
14511987-11	2003	Administration of 1 microM chicken ghrelin to pituitaries in vitro resulted in a down-regulation of both cGHS-R isoforms within 15 min, whereas after 1h levels returned to control values.	Hydrogen	150-152	ghrelin/obestatin prepropeptide	Gallus gallus	35-42
12963462-4	2003	It is supposed that Al directly coordinates with AA at O-3 moiety; also, Al can coordinate with the O-1 and O-2 moieties of ascorbate ion through the weakly binding and the intramolecular hydrogen bonding in acidic aqueous solutions.	Hydrogen	188-196	immunoglobulin kappa variable 2D-40	Homo sapiens	100-111
12866078-3	2003	GMP in [Pt(bpm)(Arg)](GMP).5 H(2)O was revealed to be bound through the pi-pi stacking and guanidinium-phosphate hydrogen bonds.	Hydrogen	113-121	5'-nucleotidase, cytosolic II	Homo sapiens	0-3
12866078-3	2003	GMP in [Pt(bpm)(Arg)](GMP).5 H(2)O was revealed to be bound through the pi-pi stacking and guanidinium-phosphate hydrogen bonds.	Hydrogen	113-121	5'-nucleotidase, cytosolic II	Homo sapiens	22-25
12837085-18	2003	The H-beta-Ala"s amino group binds to the carboxyl group to form a salt bridge, while the Aib(3) NH is hydrogen-bonded to either oxygen of the carboxylate group.	Hydrogen	103-111	ANIB1	Homo sapiens	90-93
12739977-1	2003	Inter- and intramolecular hydrogen bonding of an N-H group in pyrazole complexes was studied using ligands with two different groups at pyrazole C-3 and C-5.	Hydrogen	26-34	complement C3	Homo sapiens	145-148
12739977-4	2003	The significance of the ligands is that by placing a ligating side chain on a ring carbon (C-3), rather than on a ring nitrogen, the ring nitrogen not bound to the metal and its attached proton are available for hydrogen bonding.	Hydrogen	212-220	complement C3	Homo sapiens	91-94
12716176-9	2003	A lower limit to the homolytic bond dissociation energy (BDE) (1H --&gt; 1 + H) was estimated to be &gt;94 kcal/mol using solution phase BDEs for pzH and para-substituted phenols.	Hydrogen	63-65	homeobox D13	Homo sapiens	57-60
12716176-10	2003	The heterolytic BDE was estimated for the hydride transfer reaction 1H --&gt; 1+ + H(-) (BDE approximately 127 kcal/mol).	Hydrogen	68-70	homeobox D13	Homo sapiens	16-19
12743384-0	2003	Disordered syn-anti hydrogen-bonded chains in 3-(ferrocenylcarbonyl)propionic acid.	Hydrogen	20-28	synemin	Homo sapiens	11-14
12743384-2	2003	The carboxyl group forms hydrogen bonds in the extremely rare syn-anti chain motif, with O...O distances of 2.667 (3) and 2.655 (3) A.	Hydrogen	25-33	synemin	Homo sapiens	62-65
12696863-2	2003	(4) The 2"-OH hydroxyl protons of riboses C15 and C16 are hydrogen bond donors to the N1 atoms of adenosines A27 and A25, respectively, positioned in the minor groove of pseudoknot stem S1.	Hydrogen	58-66	placenta associated 8	Homo sapiens	42-45
12658648-2	2003	The dominant formation of this 3:1 coupling product, instead of the Heck trisubstituted olefin, shows that aromatic C-H bond activation processes can compete with the usually fast syn beta-hydrogen elimination step in the Heck arylation of an acyclic olefin.	Hydrogen	189-197	synemin	Homo sapiens	180-183
12666176-0	2003	1H-NMR studies on a potent and selective antagonist at human melanocortin receptor 4 (hMC-4R).	Hydrogen	0-2	melanocortin 4 receptor	Homo sapiens	61-84
12666176-0	2003	1H-NMR studies on a potent and selective antagonist at human melanocortin receptor 4 (hMC-4R).	Hydrogen	0-2	melanocortin 4 receptor	Homo sapiens	86-92
12644708-4	2003	The driving force is proportional to the difference in the bond-dissociation energies (BDE &gt;94 kcalmol for homolytic, 1H --&gt; H + 1, vs. approximately 127 kcalmol for heterolytic, 1H --&gt; H(-) + 1(+), dissociation of the OH bond in 1H).	Hydrogen	121-123	homeobox D13	Homo sapiens	87-90
12644708-4	2003	The driving force is proportional to the difference in the bond-dissociation energies (BDE &gt;94 kcalmol for homolytic, 1H --&gt; H + 1, vs. approximately 127 kcalmol for heterolytic, 1H --&gt; H(-) + 1(+), dissociation of the OH bond in 1H).	Hydrogen	185-187	homeobox D13	Homo sapiens	87-90
12644708-4	2003	The driving force is proportional to the difference in the bond-dissociation energies (BDE &gt;94 kcalmol for homolytic, 1H --&gt; H + 1, vs. approximately 127 kcalmol for heterolytic, 1H --&gt; H(-) + 1(+), dissociation of the OH bond in 1H).	Hydrogen	185-187	homeobox D13	Homo sapiens	87-90
12617904-3	2003	The X-ray structure of the complex of topiramate with hCA II has been solved and it revealed a very tight association of the inhibitor, with a network of seven strong hydrogen bonds fixing topiramate within the active site, in addition to the Zn(II) coordination through the ionized sulfamate moiety.	Hydrogen	167-175	carbonic anhydrase 2	Homo sapiens	54-60
12633854-6	2003	The substrate and inhibitor specificity of AnCE appears to be determined by extensive hydrogen-bonding networks and ionic interactions in the active site channel.	Hydrogen	86-94	Angiotensin converting enzyme	Drosophila melanogaster	43-47
12652138-0	2003	1H, 13C and 15N resonance assignments of the C-terminal domain of insulin-like growth factor binding protein-6 (IGFBP-6).	Hydrogen	0-2	insulin like growth factor binding protein 6	Homo sapiens	66-110
12652138-0	2003	1H, 13C and 15N resonance assignments of the C-terminal domain of insulin-like growth factor binding protein-6 (IGFBP-6).	Hydrogen	0-2	insulin like growth factor binding protein 6	Homo sapiens	112-119
12652140-0	2003	1H, 15N and 13C resonance assignments for the PTB domain of the signaling protein Shc.	Hydrogen	0-2	SHC adaptor protein 1	Homo sapiens	82-85
12929418-3	2003	Moreover the synthesis and IR and 1H NMR conformational analysis of the tetramers Boc-L-Val-D-Oxac-L-Ala-OBn and Boc-L-Val-D-Oxac-Aib-L-Ala-OBn in solution is reported.	Hydrogen	34-36	ANIB1	Homo sapiens	130-133
12515544-6	2003	Site-directed mutagenesis was used to change S272 to alanine, which would be expected to eliminate the hydrogen bond to N1 of PLP or to aspartate, which would be expected to enhance the hydrogen-bonding interaction.	Hydrogen	103-111	proteolipid protein 1	Homo sapiens	126-129
12417189-7	2003	c-fos and c-jun mRNA expression in dentin bonding agents-treated cells revealed a rapid accumulation of the transcript, a significant signal first was detectable after 1h of exposure.	Hydrogen	168-170	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
12417189-7	2003	c-fos and c-jun mRNA expression in dentin bonding agents-treated cells revealed a rapid accumulation of the transcript, a significant signal first was detectable after 1h of exposure.	Hydrogen	168-170	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	10-15
12471606-11	2003	This is probably due to the hydrogen bonding interaction formed between the OH group of Tyr99H and the sulfate group of DHEAS.	Hydrogen	28-36	sulfotransferase family 2A member 1	Homo sapiens	120-125
12536785-1	2002	The complexes TpxCu (Tpx = homoscorpionate) catalyse the insertion of diazo compounds into nitrogen-hydrogen bonds of amines and amides, under very mild conditions, with quantitative yields being obtained with equimolar ratios of reactants.	Hydrogen	100-108	thyroid peroxidase	Homo sapiens	14-17
12522303-0	2002	1H, 13C and 15N chemical shift assignments of the SH2 domain of the Csk homologous kinase.	Hydrogen	0-2	megakaryocyte-associated tyrosine kinase	Homo sapiens	68-89
12522305-0	2002	Backbone 1H, 15N, and 13C resonance assignments of the repeated domain of human beta ig-h3 protein.	Hydrogen	9-11	transforming growth factor beta induced	Homo sapiens	80-90
12466552-8	2002	Surprisingly, deletion of all of the functional groups involved in hydrogen bonds with the U1A protein by substituting adenine with 4-methylindole reduced the binding free energy by only 2.0 kcal/mol.	Hydrogen	67-75	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	91-94
12393139-2	2002	The structures of the synthesized NAP-PP hybrid esters were confirmed by IR and 1H NMR spectroscopy and their purity was established by elemental analysis, HPLC and TLC.	Hydrogen	80-82	catenin beta like 1	Homo sapiens	34-37
12368849-3	2002	Cold atoms and anti-atoms, such as hydrogen and antihydrogen, could form the basis of a new precise test, as CPT invariance implies that they must have the same spectrum.	Hydrogen	35-43	choline phosphotransferase 1	Homo sapiens	109-112
12938427-5	2002	The photos of TEM showed that the domains of hard segments became clearer with buildup of hydrogen bond between urealinks.	Hydrogen	90-98	MFT2	Homo sapiens	14-17
12203290-10	2002	Moreover, crystallization of the PTMA radical in presence of ethanol to form the beta phase of PTMA radical prevented the dimer formation; this resulted in the suppression of this interaction and provides further evidence of the magnetic exchange mechanism through noncovalent hydrogen bonds at long distances.	Hydrogen	277-285	prothymosin alpha	Homo sapiens	33-37
12203290-10	2002	Moreover, crystallization of the PTMA radical in presence of ethanol to form the beta phase of PTMA radical prevented the dimer formation; this resulted in the suppression of this interaction and provides further evidence of the magnetic exchange mechanism through noncovalent hydrogen bonds at long distances.	Hydrogen	277-285	prothymosin alpha	Homo sapiens	95-99
11994311-6	2002	We demonstrate that this key hydrogen bond contributes approximately 10-fold to the binding affinity of GCN5 HATs for acetyl-CoA.	Hydrogen	29-37	lysine acetyltransferase 2A	Homo sapiens	104-108
12100026-6	2002	Pressure treatment enhanced IL-6 mRNA expression in IECs within 6 h. Pressure loading significantly enhanced the activation of both NF-kappaB and NF-IL-6 from 1h in the nuclear protein of IEC-18 cells as assessed by the electrophoretic mobility shift assay using FITC-conjugated specific primers.	Hydrogen	159-161	CCAAT/enhancer binding protein beta	Rattus norvegicus	146-153
12086944-0	2002	An interval tightly linked to but distinct from the H2 complex controls both overt diabetes (Idd16) and chronic experimental autoimmune thyroiditis (Ceat1) in nonobese diabetic mice.	Hydrogen	52-54	insulin dependent diabetes susceptibility 16	Mus musculus	93-98
12097034-1	2002	We report on measurements of the cross section and provide first data on spin correlation parameters A(TT") and A(TL") in inclusive scattering of longitudinally polarized electrons from nuclear-polarized hydrogen.	Hydrogen	204-212	spindlin 1	Homo sapiens	73-77
12036356-3	2002	Introduction of a hydroxyl group para to the proximal amidine group increases the potency vs fXa by 1-2 orders of magnitude, which is the result of a hydrogen bond to Ser195 of the catalytic triad.	Hydrogen	150-158	coagulation factor X	Homo sapiens	93-96
11882663-3	2002	The beta(2)AR and platelet-derived growth factor receptor ligands insert into the PDZ1 binding pocket by a beta-sheet augmentation process and are stabilized by largely similar networks of hydrogen bonds and hydrophobic contacts.	Hydrogen	189-197	adrenoceptor beta 2	Homo sapiens	4-13
11882663-4	2002	In the PDZ1-beta(2)AR complex, the side chain of asparagine at position -4 in the beta(2)AR peptide forms two additional hydrogen bonds with Gly(30) of PDZ1, which contribute to the higher affinity of this interaction.	Hydrogen	121-129	adrenoceptor beta 2	Homo sapiens	12-21
11882663-4	2002	In the PDZ1-beta(2)AR complex, the side chain of asparagine at position -4 in the beta(2)AR peptide forms two additional hydrogen bonds with Gly(30) of PDZ1, which contribute to the higher affinity of this interaction.	Hydrogen	121-129	adrenoceptor beta 2	Homo sapiens	82-91
11884405-7	2002	Paradoxically, Y168F AANAT showed 10-fold enhanced apparent affinity for acetyl-CoA despite the loss of a hydrogen bond between the Tyr phenol and the CoA sulfur atom.	Hydrogen	106-114	aralkylamine N-acetyltransferase	Homo sapiens	21-26
11889129-5	2002	Patterns of NOEs and (1)H(alpha) and (13)C chemical shifts show that hLtn rearranges under these conditions to form a four-stranded, antiparallel beta-sheet with a pattern of hydrogen bonding that is completely different from that of the chemokine fold stabilized at 10 degrees C and 200 mm NaCl.	Hydrogen	175-183	X-C motif chemokine ligand 1	Homo sapiens	69-73
11964255-5	2002	The bound conformation allows direct hydrogen bonds to form between the sugar and K182 of MBP, in addition to other water-mediated hydrogen bonds.	Hydrogen	37-45	myelin basic protein	Rattus norvegicus	90-93
11964255-5	2002	The bound conformation allows direct hydrogen bonds to form between the sugar and K182 of MBP, in addition to other water-mediated hydrogen bonds.	Hydrogen	131-139	myelin basic protein	Rattus norvegicus	90-93
12069484-0	2002	Hydrogen bonds and the catalytic mechanism of human carbonic anhydrase II.	Hydrogen	0-8	carbonic anhydrase 2	Homo sapiens	52-73
11829614-3	2002	A dynamic transformation of the Ca(II) zigzag-chain structure to the cyclic-octanuclear complex was induced by changing coordination of DMF molecules, which caused a reorganization of the intermolecular/intramolecular hydrogen bond network.	Hydrogen	218-226	carbonic anhydrase 2	Homo sapiens	32-38
11788718-4	2002	Here we probe how mutation of Phe56 affects the kinetics of complex dissociation, the strength of the hydrogen bonds formed between U1A and the base that stacks with Phe56 (A6) and specific target site recognition.	Hydrogen	102-110	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	132-135
11788718-7	2002	Simultaneous modification of residue 56 and A6 revealed energetic coupling between the aromatic group and the functional groups of A6 that hydrogen bond to U1A.	Hydrogen	139-147	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	156-159
11834591-8	2002	In the non-HS group, increased EAAT2-IR was detected in the CA1 and CA2 field, compared with non-epileptic controls.	Hydrogen	11-13	carbonic anhydrase 1	Homo sapiens	60-63
11834591-8	2002	In the non-HS group, increased EAAT2-IR was detected in the CA1 and CA2 field, compared with non-epileptic controls.	Hydrogen	11-13	carbonic anhydrase 2	Homo sapiens	68-71
11834591-12	2002	In the HS group, the percentage of EAAT3-IR neurones was increased in CA2 and in the granule cell layer of the dentate gyrus.	Hydrogen	7-9	carbonic anhydrase 2	Homo sapiens	70-73
11834591-16	2002	The results indicate an upregulation of EAAT2 protein expression in CA1 and CA2 in neurones in the non-HS group.	Hydrogen	103-105	carbonic anhydrase 1	Homo sapiens	68-71
11733024-4	2001	We report here that amino-acid substitutions in a buried cluster of three residues forming a hydrogen bonding network in the shutter region drastically accelerate PAI-1 latency transition; that the rate was in all cases normalized by the PAI-1 binding protein vitronectin; and that substitution of an adjacent beta strand 5A Lys residue, believed to anchor beta strand 5A to other secondary structural elements, had differential effects on the rates of latency transition in the absence and the presence of vitronectin, respectively.	Hydrogen	93-101	vitronectin	Homo sapiens	260-271
11733024-4	2001	We report here that amino-acid substitutions in a buried cluster of three residues forming a hydrogen bonding network in the shutter region drastically accelerate PAI-1 latency transition; that the rate was in all cases normalized by the PAI-1 binding protein vitronectin; and that substitution of an adjacent beta strand 5A Lys residue, believed to anchor beta strand 5A to other secondary structural elements, had differential effects on the rates of latency transition in the absence and the presence of vitronectin, respectively.	Hydrogen	93-101	vitronectin	Homo sapiens	507-518
11824759-0	2001	1H, 13C and 15N chemical shift assignments of the N-terminal PAS domain of mNPAS2.	Hydrogen	0-2	neuronal PAS domain protein 2	Mus musculus	75-81
11668458-2	2001	Residue-level features of bovine pancreatic trypsin inhibitor (BPTI) unfolding on reversed-phase chromatography (RPC) surfaces were investigated using hydrogen-deuterium exchange labeling and NMR.	Hydrogen	151-159	spleen trypsin inhibitor I	Bos taurus	26-61
11763223-2	2001	The reaction of acid with the metallic interior hull of the ship and the accompanying heat and H2 production resulted in an imminent risk of explosion.	Hydrogen	95-97	inositol polyphosphate-5-phosphatase D	Homo sapiens	60-64
11477109-9	2001	Val-349 contacts C-2 and C-3 of EPA and C-4 of LA orienting the carboxyl halves of these substrates so that the omega-ends are aligned properly for hydrogen abstraction.	Hydrogen	148-156	complement C3	Homo sapiens	25-28
11583786-0	2001	Theoretical evaluation of the hydrogen kinetic isotope effect on the first step of the methylmalonyl-CoA mutase reaction.	Hydrogen	30-38	methylmalonyl-CoA mutase	Homo sapiens	87-111
11583786-1	2001	We have calculated hydrogen kinetic isotope effects (KIEs) for the first step of the methylmalonyl-CoA mutase reaction, including multidimensional tunneling correction at the zero curvature (ZCT) level, and compared them with the experimental values.	Hydrogen	19-27	methylmalonyl-CoA mutase	Homo sapiens	85-109
11535073-6	2001	This indicated that the C4" hydrogens of the two nucleotides located at the strongest cleavage sites, C11 on one strand and A5 on the other, were oriented toward each other in the minor groove.	Hydrogen	28-37	aldo-keto reductase family 1 member C4	Homo sapiens	102-105
11525656-4	2001	The endocyclic effect is subsequently capitalized upon to control the hydrogen transfer step so that the syn-reduced product may be achieved.	Hydrogen	70-78	synemin	Homo sapiens	105-108
11562191-1	2001	A 25-residue disulfide-cross-linked peptide, termed "oxidized core module" (OxCM), that includes essentially all of the secondary structural elements of bovine pancreatic trypsin inhibitor (BPTI) most refractory to hydrogen exchange, was shown previously to favor nativelike beta-sheet structure [Carulla, N., Woodward, C., and Barany, G. (2000) Synthesis and Characterization of a beta-Hairpin Peptide That Represents a "Core Module" of Bovine Pancreatic Trypsin Inhibitor (BPTI).	Hydrogen	215-223	spleen trypsin inhibitor I	Bos taurus	190-194
11514664-9	2001	In contrast, azide is bound to the oxidized heme iron in the methemoglobin crystals at an angle of 112 degrees, in a perfect orientation to accept a hydrogen bond from His63.	Hydrogen	149-157	hemoglobin subunit gamma 2	Homo sapiens	61-74
11463854-5	2001	Molecular modeling of this inactivating TSH receptor mutation revealed potential interaction partners of R633 in transmembrane domain 3 and/or transmembrane domain 7, presumably via hydrogen bonds that could be responsible for locking the TSH receptor in a completely inactive state.	Hydrogen	182-190	thyroid stimulating hormone receptor	Homo sapiens	40-52
11463854-5	2001	Molecular modeling of this inactivating TSH receptor mutation revealed potential interaction partners of R633 in transmembrane domain 3 and/or transmembrane domain 7, presumably via hydrogen bonds that could be responsible for locking the TSH receptor in a completely inactive state.	Hydrogen	182-190	thyroid stimulating hormone receptor	Homo sapiens	239-251
11463854-10	2001	Moreover, the mutagenesis results, together with a three-dimensional structure model, indicate that for TSH receptor activation and G protein-coupled signaling, at least one free available carboxylate oxygen is required as a hydrogen acceptor atom at position 674 in transmembrane domain 7.	Hydrogen	225-233	thyroid stimulating hormone receptor	Homo sapiens	104-116
11463299-2	2001	[reaction: see text] A tandem process featuring intramolecular aminyl radical cyclofunctionalization and hydrogen transfer affords 2,3-trans-disubstituted pyrrolidines with anti or syn diastereoselectivity.	Hydrogen	105-113	synemin	Homo sapiens	181-184
11425306-11	2001	Comparison to a structure of rabbit PGI with 5PAA bound indicates that ring opening is followed by loss of the protonated water molecule and conformational changes in the substrate and the protein so that a helix containing amino acids 513-520 moves in toward the substrate to form additional hydrogen bonds with the substrate.	Hydrogen	293-301	glucose-6-phosphate isomerase	Oryctolagus cuniculus	36-39
11519755-0	2001	1H, 13C and 15N backbone assignments for the C-terminal globular domain of agrin.	Hydrogen	0-2	agrin	Homo sapiens	75-80
11389630-4	2001	Furthermore, evidence is presented that indicates that stabilization by an interaction involving the syn C-3 hydrogen of cyclopropene and butadiene is small or irrelevant in controlling the endo-exo selectivity of the Diels-Alder reaction.	Hydrogen	109-117	synemin	Homo sapiens	101-104
11472013-1	2001	A derivative of rat microsomal cytochrome b5, obtained by substitution of the native heme moiety with protoporphyrin IX dimethyl ester, has been characterized by 1H and 15N NMR spectroscopy.	Hydrogen	162-164	cytochrome b5 type A	Rattus norvegicus	31-44
11325255-1	2001	Theoretical analysis within the frame of the Topological Theory of Atoms in Molecules confirms the repulsive steric interaction between an axial dimethylphosphinoyl group and the syn-diaxial hydrogens in cyclohexane derivative 2-ax.	Hydrogen	191-200	synemin	Homo sapiens	179-182
11398989-4	2001	Of these, the 7C5/1S5 chair/skew boat form 2d has the lowest potential energy, and is largely consistent with the observed vicinal 1H-1H NMR coupling constants.	Hydrogen	131-133	ataxin 1 like	Homo sapiens	33-37
11398989-4	2001	Of these, the 7C5/1S5 chair/skew boat form 2d has the lowest potential energy, and is largely consistent with the observed vicinal 1H-1H NMR coupling constants.	Hydrogen	134-136	ataxin 1 like	Homo sapiens	33-37
11148208-9	2001	Probing the peptide microenvironment in gp96-peptide complexes, suggested that hydrophobic interactions (and perhaps hydrogen bonding/stacking interactions) may play a role in peptide loading by gp96.	Hydrogen	117-125	heat shock protein 90 beta family member 1	Homo sapiens	40-44
11148208-9	2001	Probing the peptide microenvironment in gp96-peptide complexes, suggested that hydrophobic interactions (and perhaps hydrogen bonding/stacking interactions) may play a role in peptide loading by gp96.	Hydrogen	117-125	heat shock protein 90 beta family member 1	Homo sapiens	195-199
11255150-0	2001	Utilization of a palladium-metal oxide semiconductor (Pd-MOS) sensor for on-line monitoring of dissolved hydrogen in anaerobic digestion.	Hydrogen	105-113	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	57-60
11255150-1	2001	The use of a hydrogen-sensitive palladium-metal oxide semiconductor (Pd-MOS) sensor in combination with a membrane for liquid-to-gas transfer for the detection of dissolved hydrogen was investigated.	Hydrogen	13-21	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	72-75
11121413-8	2001	A V349A substitution caused an 800-fold decrease in the V(max)/K(m) for DHLA but less than a 2-fold change with AA; kinetic evidence indicates that C-13 of DHLA is improperly positioned with respect to Tyr-385 in the V349A mutant thereby preventing efficient hydrogen abstraction.	Hydrogen	259-267	homeobox C13	Homo sapiens	148-152
11257229-3	2001	The hydrogen bonding network formed among CBFalpha(Runt domain) and CBFbeta, and CBFalpha(Runt domain) and DNA revealed the allosteric regulation mechanism of CBFalpha(Runt domain)-DNA binding by CBFbeta.	Hydrogen	4-12	nuclear transcription factor Y subunit alpha	Homo sapiens	42-50
11297347-1	2001	The possible influence of thermal motion on 1H chemical shifts is discussed for a small stable protein, the bovine pancreatic Kunitz trypsin inhibitor (BPTI).	Hydrogen	44-46	spleen trypsin inhibitor I	Bos taurus	152-156
11250198-8	2001	Interaction with the degenerate position is mediated by a purine-specific hydrogen bond to N7, ensuring specificity, and water-mediated H bonding to the purine N6/O6 and pyrimidine N4/O4, allowing degeneracy.	Hydrogen	74-82	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	160-165
11152614-6	2001	Water was critical to the inverse temperature transition and elastin-associated water molecules can be divided into three categories: those closely associated with beta II turns; those that form hydrogen bonds with the main-chain groups; and those hydrating the hydrophobic side-chains.	Hydrogen	195-203	elastin	Homo sapiens	61-68
11152614-7	2001	Water-swollen, monomeric elastin above the transition temperature is best described as a compact amorphous structure with distorted beta-strands, fluctuating turns, buried hydrophobic residues, and main-chain polar atoms that participate in hydrogen bonds with water.	Hydrogen	241-249	elastin	Homo sapiens	25-32
11152615-2	2001	A previous pH-dependent equilibrium hydrogen exchange (HX) study identified a subset of amides in CD2.d1 which, under EX2 conditions, exchange from N with free energies greater than or equal to the free energy difference between the N and I states calculated from the stopped-flow data.	Hydrogen	36-44	Cd2 molecule	Rattus norvegicus	98-104
11168357-15	2001	Evaluation of the two mutations at His480 allows us to propose that this residue may participate in the aromatization reaction (the third step) by acting as a hydrogen bond donor for the C-3 keto group of the substrate.	Hydrogen	159-167	complement C3	Homo sapiens	187-190
11118321-8	2000	The dUTPase cDNA from Drosophila melanogaster was identified, sequenced, and the model structure of the encoded polypeptide displayed a polar hydrogen-bonding network of threefold interactions, identically to the human structure.	Hydrogen	142-150	Deoxyuridine triphosphatase	Drosophila melanogaster	4-11
11106395-4	2000	Mutational analyses of residues contacting the alkylated base in the crystal structures suggest that the shape of the damaged base, its hydrogen-bonding characteristics, and its aromaticity all contribute to the selective recognition of damage by AAG.	Hydrogen	136-144	N-methylpurine DNA glycosylase	Homo sapiens	247-250
10884383-10	2000	An electron-withdrawing or hydrogen bond acceptor moiety at C8 is required for efficient binding of mOgg1.	Hydrogen	27-35	8-oxoguanine DNA-glycosylase 1	Mus musculus	100-105
10751412-1	2000	The glutathione S-transferase enzymes (GSTs) have a tyrosine or serine residue at their active site that hydrogen bonds to and stabilizes the thiolate anion of glutathione, GS(-).	Hydrogen	105-113	glutathione S-transferase alpha 2	Rattus norvegicus	39-43
10906412-1	2000	Based on NN703, low molecular weight growth hormone secretagouges (GHSs) with a reduced number of hydrogen binding sites were designed by removal of the C-terminal amide group.	Hydrogen	98-106	somatotropin	Canis lupus familiaris	37-51
10860725-7	2000	The 2" hydroxyl group of g15 is hydrogen bonded to O2P and O5" of g17, skipping the bulged adenine a16 and stabilizing the sugar-phosphate backbone of the hybrid.	Hydrogen	32-40	PBX homeobox 2	Homo sapiens	66-69
10860726-7	2000	The syn adenine bases form minor groove A*(G.C) base triples with C8-H...N2 hydrogen bonds.	Hydrogen	76-84	synemin	Homo sapiens	4-7
10808442-2	2000	The occurrence of the C7 to C11 hydrogen migration has been demonstrated by labeling experiments.	Hydrogen	32-40	RNA polymerase III subunit K	Homo sapiens	28-31
10820035-6	2000	For the cis isomer, the residue adopts a syn orientation and is able to form a second hydrogen bond with the guanine on the 5" side on the same strand.	Hydrogen	86-94	synemin	Homo sapiens	41-44
10775064-6	2000	Namely, for peptide Z-I, only Val NH participates in intramolecular hydrogen bonding, which leads to a type II beta-turn conformation supported by hydrogen bonding between CO(Boc) and NH(Val).	Hydrogen	68-76	BOC cell adhesion associated, oncogene regulated	Homo sapiens	175-178
10775064-6	2000	Namely, for peptide Z-I, only Val NH participates in intramolecular hydrogen bonding, which leads to a type II beta-turn conformation supported by hydrogen bonding between CO(Boc) and NH(Val).	Hydrogen	147-155	BOC cell adhesion associated, oncogene regulated	Homo sapiens	175-178
10775064-9	2000	Based on the nmr data and conformational energy calculation, it should be concluded that peptide E-I takes two consecutive gamma-turn conformations supported by hydrogen bonding between CO(Boc) and NH(delta(E)Phe), and between CO(Ala) and NH(Val) as its plausible conformation.	Hydrogen	161-169	BOC cell adhesion associated, oncogene regulated	Homo sapiens	189-192
10727931-8	2000	1H NMR spectroscopy reveals that deletion of the C-terminal extension of Hsp25 leads to induction of extra C-terminal flexibility in the molecule.	Hydrogen	0-2	heat shock protein 1	Mus musculus	73-78
10727931-9	2000	Monitoring complex formation between Hsp25 and dithiothreitol-reduced alpha-lactalbumin by 1H NMR spectroscopy indicates that the C-terminal extension of Hsp25 retains its flexibility during this interaction.	Hydrogen	91-93	heat shock protein 1	Mus musculus	37-42
10727931-9	2000	Monitoring complex formation between Hsp25 and dithiothreitol-reduced alpha-lactalbumin by 1H NMR spectroscopy indicates that the C-terminal extension of Hsp25 retains its flexibility during this interaction.	Hydrogen	91-93	heat shock protein 1	Mus musculus	154-159
10746608-0	2000	Evidence for long-term neurotoxicity associated with methamphetamine abuse: A 1H MRS study.	Hydrogen	78-80	MROS	Homo sapiens	81-84
10746608-1	2000	OBJECTIVE: To determine whether proton MRS (1H MRS) can detect long-term metabolite abnormalities in abstinent methamphetamine users.	Hydrogen	44-46	MROS	Homo sapiens	39-42
10746608-8	2000	CONCLUSIONS: The reduced [NA] on 1H MRS provides evidence for long-term neuronal damage in abstinent methamphetamine users.	Hydrogen	33-35	MROS	Homo sapiens	36-39
10702277-6	2000	X-ray crystallography of PTP1B complexed with OBA and related non-phosphate low molecular weight derivatives reveals that the binding mode of these molecules to a large extent mimics that of the natural substrate including hydrogen bonding to the PTP signature motif.	Hydrogen	223-231	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	25-30
10857912-0	2000	A 1H NMR study of the oligonucleotide binding of [(en)Pt(mu-dpzm)2Pt(en)]Cl4.	Hydrogen	2-4	endogenous retrovirus group W member 3	Homo sapiens	73-76
10767769-0	2000	Hydrogen-deuterium exchange signature of porcine cerebroside sulfate activator protein.	Hydrogen	0-8	ganglioside GM2 activator	Homo sapiens	49-86
10767769-11	2000	The hydrogen-deuterium exchange profile will be a valuable criterion for characterizing mutant forms of CSAct produced by recombinant and synthetic paradigms and also the native and mutant forms of related proteins.	Hydrogen	4-12	ganglioside GM2 activator	Homo sapiens	104-109
10671506-9	2000	This can rationalize abstraction of the C-13 pro-S hydrogen, the blocking of prostaglandin synthesis, and the formation of 15R-HETE as the sole enzymatic product.	Hydrogen	51-59	homeobox C13	Homo sapiens	40-44
11263244-6	2000	The N-terminal residues (especially Met1 and Gln4) of human CCR5 contacted with CD4 residues, mainly with one span (56-59) of CD4 in electrostatic interaction and hydrogen-bonds.	Hydrogen	163-171	C-C motif chemokine receptor 5	Homo sapiens	60-64
11263244-8	2000	On the other hand, direct interatomic contacts were made between 7 CCR5 residues and 6 gp120 amino-acid residues, which included van der Waals contacts, hydrophobic interaction, and hydrogen bonds.	Hydrogen	182-190	C-C motif chemokine receptor 5	Homo sapiens	67-71
10695607-1	2000	The hydrogen breath test (H2BT) with D-xylose has proven valid in both early recognition and follow-up of intestinal malabsorption.	Hydrogen	4-12	H2B clustered histone 20, pseudogene	Homo sapiens	26-30
10581248-5	1999	Side chain hydroxyl groups of Ser119, Ser120 and Tyr82 in cofilin form hydrogen bonds with main chain carbonyl moieties from the helix, causing the kink.	Hydrogen	71-79	cofilin	Saccharomyces cerevisiae S288C	58-65
10457361-5	1999	Furthermore, the transport of glycolytic hydrogen, produced by the glyceraldehyde 3-phosphate dehydrogenase-catalyzed reaction, from the cytosol into the mitochondria by means of the malate-aspartate shuttle was enhanced, this being due to alterations in the activities of malate dehydrogenase and glutamate oxaloacetate transaminase.	Hydrogen	41-49	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	67-107
10550681-6	1999	Several hydrogen bonds involving active site residues Thr199 and Thr200 as well as three water molecules (Wat99, Wat122, and Wat123) further stabilize the urea-hCA II adduct.	Hydrogen	8-16	carbonic anhydrase 2	Homo sapiens	160-166
10480597-5	1999	The glucose is predicted to form hydrogen bond interactions with the side chains of glucokinase residues Thr 168, Lys 169, Asn 204, Asp 205, Asn 231, and Glu 290, similar to those observed for brain hexokinase I.	Hydrogen	33-41	glucokinase	Homo sapiens	84-95
11969868-0	1999	Plasma-insulator transition of spin-polarized hydrogen.	Hydrogen	46-54	spindlin 1	Homo sapiens	31-35
11969868-1	1999	A mixed classical-quantum density functional theory is used to calculate pair correlations and the free energy of a spin-polarized hydrogen plasma.	Hydrogen	131-139	spindlin 1	Homo sapiens	116-120
11969868-3	1999	Spin polarization is imposed to prevent the formation of H2 molecules.	Hydrogen	57-59	spindlin 1	Homo sapiens	0-4
10221918-1	1999	The ability of the GroEL chaperonin to unfold a protein trapped in a misfolded condition was detected and studied by hydrogen exchange.	Hydrogen	117-125	heat shock protein family D (Hsp60) member 1	Homo sapiens	19-24
10090736-7	1999	In meta-binding site I, the side chain of Glu209 (EL2) is within hydrogen-bonding distance (2.8 A) of the ribose O3", and Arg287 (EL3) coordinates both alpha- and beta-phosphates of the triphosphate chain, consistent with the insensitivity in potency of the 5"-monophosphate agonist, HT-AMP, to mutation of Arg287 to Lys.	Hydrogen	65-73	spectrin alpha, erythrocytic 1	Homo sapiens	50-53
10094490-0	1999	Denatured states of human carbonic anhydrase II: an NMR study of hydrogen/deuterium exchange at tryptophan-indole-H(N) sites.	Hydrogen	65-73	carbonic anhydrase 2	Homo sapiens	26-47
10022353-7	1999	In all the computationally predicted synthetic inhibitor complexes of FXa, the specificity pocket residue Asp-189 is involved in hydrogen bonding with the bound inhibitor.	Hydrogen	129-137	coagulation factor X	Homo sapiens	70-73
10024175-4	1999	We compare the dynamics, hydrogen-bonding occupancies, and interfacial flexibility of both complexes and also describe a rigid-body motion in the U1A-internal loop complex that is not observed in the U1A-hairpin simulation.	Hydrogen	25-33	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	146-149
11670827-14	1998	However, if such phosphate-NH hydrogen bonds exist, they are weak since the percentage of the major HT form of 5"-GMP complexes is similar and indeed can be smaller compared to this percentage for complexes with other G"s.	Hydrogen	30-38	5'-nucleotidase, cytosolic II	Homo sapiens	114-117
9882408-2	1998	The procedure utilized preparative hydrazinolysis to release the oligosaccharide and yielded multi-micromol quantities of Boc-tyrosine-Man9 which was characterized by 1H NMR and ES-MS.	Hydrogen	167-169	mannosidase alpha class 1A member 1	Homo sapiens	135-139
9836577-6	1998	One such difference implies that NT-3"s binding affinity and specificity depend on a novel hydrogen bond between Gln 83, a residue important for binding specificity with TrkC, and Arg 103, a residue crucial for binding affinity with TrkC.	Hydrogen	91-99	neurotrophin 3	Homo sapiens	33-37
9836577-6	1998	One such difference implies that NT-3"s binding affinity and specificity depend on a novel hydrogen bond between Gln 83, a residue important for binding specificity with TrkC, and Arg 103, a residue crucial for binding affinity with TrkC.	Hydrogen	91-99	neurotrophic receptor tyrosine kinase 3	Homo sapiens	170-174
9836577-8	1998	A comparison of the dimer interface between the NT-3 homodimer and the BDNF/NT-3 heterodimer reveals similar patterns of hydrogen bonds and nonpolar contacts, which reinforces the notion that the evolutionarily conserved neurotrophin interface resulted from the need for receptor dimerization in signal initiation.	Hydrogen	121-129	neurotrophin 3	Homo sapiens	48-52
9836577-8	1998	A comparison of the dimer interface between the NT-3 homodimer and the BDNF/NT-3 heterodimer reveals similar patterns of hydrogen bonds and nonpolar contacts, which reinforces the notion that the evolutionarily conserved neurotrophin interface resulted from the need for receptor dimerization in signal initiation.	Hydrogen	121-129	brain derived neurotrophic factor	Homo sapiens	71-75
9925306-4	1998	A number of contacts shorter than the conventional van der Waals distance have been disclosed between CH hydrogens and aromatic side-chain groups in the MHC/peptide complexes.	Hydrogen	105-114	major histocompatibility complex, class I, C	Homo sapiens	153-156
9834217-6	1998	GM-CSF-mediated augmentation of survival, phagocytosis, and hydrogen-ion production were absent in neutrophils from betac-null mice.	Hydrogen	60-68	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
9846878-3	1998	The NMR structure of the Numb PTB domain in complex with a GPpY-containing peptide reveals a novel mechanism of binding with the peptide in a helical turn that does not hydrogen bond to the PTB domain beta-sheet.	Hydrogen	169-177	NUMB endocytic adaptor protein	Homo sapiens	25-29
9865949-1	1998	Stringent specificity and complementarity between the receptor, a periplasmic phosphate-binding protein (PBP) with a two-domain structure, and the completely buried and dehydrated phosphate are achieved by hydrogen bonding or dipolar interactions.	Hydrogen	206-214	phosphatidylethanolamine binding protein 1	Homo sapiens	105-108
9789022-4	1998	The crystal structure of TTR complexed with Flu demonstrates that Flu mediates intersubunit hydrophobic interactions and intersubunit hydrogen bonds that stabilize the normal tetrameric fold of TTR.	Hydrogen	134-142	transthyretin	Homo sapiens	25-28
9789022-4	1998	The crystal structure of TTR complexed with Flu demonstrates that Flu mediates intersubunit hydrophobic interactions and intersubunit hydrogen bonds that stabilize the normal tetrameric fold of TTR.	Hydrogen	134-142	transthyretin	Homo sapiens	194-197
9835055-0	1998	Assignment of 1H and 15N resonances of murine Tec SH3 domain.	Hydrogen	14-16	tec protein tyrosine kinase	Mus musculus	46-49
9748320-3	1998	In the crystal structure of the thrombin E192Q-BPTI complex, the reactive site loop of BPTI is stabilized in a canonical conformation by several productive interactions (e.g., Glu39 of thrombin is ion-paired to the P5" Arg, and Gln192 is hydrogen-bonded to the P2 and P4 backbone carbonyls of BPTI).	Hydrogen	238-246	coagulation factor II, thrombin	Bos taurus	32-40
9748320-3	1998	In the crystal structure of the thrombin E192Q-BPTI complex, the reactive site loop of BPTI is stabilized in a canonical conformation by several productive interactions (e.g., Glu39 of thrombin is ion-paired to the P5" Arg, and Gln192 is hydrogen-bonded to the P2 and P4 backbone carbonyls of BPTI).	Hydrogen	238-246	spleen trypsin inhibitor I	Bos taurus	47-51
9748320-3	1998	In the crystal structure of the thrombin E192Q-BPTI complex, the reactive site loop of BPTI is stabilized in a canonical conformation by several productive interactions (e.g., Glu39 of thrombin is ion-paired to the P5" Arg, and Gln192 is hydrogen-bonded to the P2 and P4 backbone carbonyls of BPTI).	Hydrogen	238-246	spleen trypsin inhibitor I	Bos taurus	87-91
9748320-3	1998	In the crystal structure of the thrombin E192Q-BPTI complex, the reactive site loop of BPTI is stabilized in a canonical conformation by several productive interactions (e.g., Glu39 of thrombin is ion-paired to the P5" Arg, and Gln192 is hydrogen-bonded to the P2 and P4 backbone carbonyls of BPTI).	Hydrogen	238-246	coagulation factor II, thrombin	Bos taurus	185-193
9748320-3	1998	In the crystal structure of the thrombin E192Q-BPTI complex, the reactive site loop of BPTI is stabilized in a canonical conformation by several productive interactions (e.g., Glu39 of thrombin is ion-paired to the P5" Arg, and Gln192 is hydrogen-bonded to the P2 and P4 backbone carbonyls of BPTI).	Hydrogen	238-246	spleen trypsin inhibitor I	Bos taurus	87-91
9737849-2	1998	The sequential assignments of the 1H, 13C, and 15N resonances of apo-CRABPII were established by multinuclear, multidimensional NMR spectroscopy.	Hydrogen	34-36	cellular retinoic acid binding protein 2	Homo sapiens	69-76
9796859-0	1998	1H NMR conformational study on N-terminal nonapeptide sequences of HIV-1 Tat protein: a contribution to structure-activity relationships.	Hydrogen	0-2	Tat	Human immunodeficiency virus 1	73-76
9698569-5	1998	The solution structure of monomeric transthyretin under fibril-forming conditions was studied using hydrogen exchange monitored by mass spectrometry.	Hydrogen	100-108	transthyretin	Homo sapiens	36-49
9698569-6	1998	The results show that Val30Met transthyretin, the commonest amyloidogenic variant, exhibits loss of hydrogen exchange protection substantially more rapidly than the wild-type protein, suggesting partial unfolding of the beta-sheet structure.	Hydrogen	100-108	transthyretin	Homo sapiens	31-44
11670509-5	1998	Two intramolecular hydrogen bonds between the chloro ligands and the acidic NH protons should stabilize the syn-endo disposition of the thiolate type bridging ligands.	Hydrogen	19-27	synemin	Homo sapiens	108-111
9671539-0	1998	Styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 12: minor groove structures of the R(12,1)- and S(12,1)-alpha-(N2-guanyl) stereoisomers determined by 1H nuclear magnetic resonance.	Hydrogen	184-186	NRAS proto-oncogene, GTPase	Homo sapiens	70-75
9729790-0	1998	Complete assignment of 1H, 13C and 15N chemical shifts for bovine beta-lactoglobulin: secondary structure and topology of the native state is retained in a partially unfolded form.	Hydrogen	23-25	beta-lactoglobulin	Bos taurus	66-84
9674779-1	1998	OBJECTIVE: To determine the 1H MRS findings in patients with intractable temporal lobe epilepsy (TLE) who had no detectable abnormality on either qualitative or quantitative MRI.	Hydrogen	28-30	MROS	Homo sapiens	31-34
9674779-3	1998	Single-voxel 1H MRS provides a means of identifying potentially diffuse disease.	Hydrogen	13-15	MROS	Homo sapiens	16-19
9711498-1	1998	Based on the absorbance change of indicators with the concentration of hydrogen ion released from an enzyme-catalyzed reaction, a convenient colorimetric method was established for the assay of acidic phospholipase A2 and glycogen phosphorylase b.	Hydrogen	71-79	glycogen phosphorylase B	Homo sapiens	222-246
9442067-6	1998	The key differences between the structures of active horseradish peroxidase C and inactive BP 1 include the orientation of the catalytic distal histidine, disruption of a hydrogen bond between this histidine and a conserved asparagine, and apparent substitution of calcium at the distal cation binding site with sodium at pH 7.5.	Hydrogen	171-179	prx7	Hordeum vulgare	65-75
9448728-6	1998	The stereochemistry of the hydrogen which was removed from C-11 during the conversion of linoleic acid into hydroxy acids in the presence of PGHS-1 or PGHS-2 was determined by incubation of [(11R)-2H]- and [(11S)-2H]linoleic acids followed by mass spectrometric analysis of the isotope contents of the individual hydroxy acid isomers.	Hydrogen	27-35	aldo-keto reductase family 1 member C4	Homo sapiens	59-63
9425037-1	1998	The solution structure of oxidized rat microsomal cytochrome b5 has been obtained from 1H NMR spectra measured at 800 MHz.	Hydrogen	87-89	cytochrome b5 type A	Rattus norvegicus	50-63
9462844-2	1998	1H-NMR analyses revealed EDTA in the total-volume fractions of a gel-filtration experiment, where all the inhibitory activity of the FGF-1 preparation was recovered.	Hydrogen	0-2	fibroblast growth factor 1	Rattus norvegicus	133-138
9923703-3	1998	In this paper, we report the assignment of backbone 1H alpha, 1HN, 15N, 13C", 13C alpha, and aliphatic 13C resonances of a fragment of rat Nedd4 (rNedd4) containing the two C-terminal WW domains, WW(II+III), complexed to a PY motif-containing peptide derived from the beta subunit of rat ENaC, the betaP2 peptide.	Hydrogen	52-54	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	139-144
9923703-3	1998	In this paper, we report the assignment of backbone 1H alpha, 1HN, 15N, 13C", 13C alpha, and aliphatic 13C resonances of a fragment of rat Nedd4 (rNedd4) containing the two C-terminal WW domains, WW(II+III), complexed to a PY motif-containing peptide derived from the beta subunit of rat ENaC, the betaP2 peptide.	Hydrogen	52-54	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	146-152
9923703-5	1998	Triple resonance experiments that detect the 1H alpha chemical shift were necessary to complete the chemical shift assignment, owing to the large number of proline residues in this fragment of rNedd4.	Hydrogen	45-47	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	193-199
10022067-3	1998	Detailed analysis of the digester biomass after 5 years of operation indicated that H2 and propionate-utilising SRB had outcompeted hydrogenophilic methanogens and propionate syntrophs.	Hydrogen	84-86	chaperonin containing TCP1 subunit 4	Homo sapiens	112-115
9438869-10	1997	F2 in mzTBN-F1 forms novel hydrogen bonds to the carbohydrate chain of thrombin and perhaps stabilizes a unique, rigid conformation of the gamma-autolysis loop through non-local effects.	Hydrogen	27-35	coagulation factor II, thrombin	Bos taurus	71-79
9275236-9	1997	The structures of human destrin and yeast cofilin indicate a hydrogen distance of 2.61 and 2.77 A, respectively, with corresponding bond angles of 99.5 degrees and 113 degrees, close to the optimum for a strong hydrogen bond.	Hydrogen	61-69	cofilin	Saccharomyces cerevisiae S288C	42-49
9275236-9	1997	The structures of human destrin and yeast cofilin indicate a hydrogen distance of 2.61 and 2.77 A, respectively, with corresponding bond angles of 99.5 degrees and 113 degrees, close to the optimum for a strong hydrogen bond.	Hydrogen	211-219	cofilin	Saccharomyces cerevisiae S288C	42-49
9300483-2	1997	We have assigned NMR 1H, 15N, and 13C chemical shifts for the entire minimal DNA-binding domain of ADR1 both free and bound to specific DNA.	Hydrogen	21-23	DNA-binding transcription factor ADR1	Saccharomyces cerevisiae S288C	99-103
9288173-5	1997	The essential role of the carbonyl moiety as a primary pharmacophoric element in the recognition by and the binding to PBR has been confirmed, and the restricted range of the carbonyl orientations, which characterizes the most potent ligands, points to a specific hydrogen-bonding interaction, mainly directed by the geometrical factors, when the electronic ones are fulfilled.	Hydrogen	264-272	translocator protein	Homo sapiens	119-122
9301108-3	1997	From the results of 1H- and 13C-NMR spectroscopic analyses by DQF-COSY and HMQC and an infrared spectroscopic analysis, it was revealed that the ordered structure of beta-1,3-xylan as a triple helix had decayed and the resulting conformational changes had been caused by the sulfation reaction.	Hydrogen	20-22	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	166-174
9201964-0	1997	Three-dimensional structure and position of porcine motilin in sodium dodecyl sulfate micelles determined by 1H NMR.	Hydrogen	109-111	motilin	Homo sapiens	52-59
9201964-1	1997	The solution structure of the porcine gastrointestinal peptide hormone motilin was determined in the presence of sodium dodecyl sulfate (SDS) micelles at 28 degrees C using 1H nuclear magnetic resonance, full relaxation matrix analysis, and structure calculations based on restrained molecular dynamics.	Hydrogen	173-175	motilin	Homo sapiens	71-78
9249051-5	1997	The present NMR study reports assignments of 1H and 13C resonances of the bound saccharidic chain NeuNAc(alpha2-3)Gal(beta1-3)[NeuNAc(alpha2-6)]GalNAc, where NeuNAc represents N-acetylneuraminic acid, and demonstrates the alpha-anomeric configuration of the N-acetylgalactosamine-threonine linkage.	Hydrogen	45-47	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	118-125
9249051-5	1997	The present NMR study reports assignments of 1H and 13C resonances of the bound saccharidic chain NeuNAc(alpha2-3)Gal(beta1-3)[NeuNAc(alpha2-6)]GalNAc, where NeuNAc represents N-acetylneuraminic acid, and demonstrates the alpha-anomeric configuration of the N-acetylgalactosamine-threonine linkage.	Hydrogen	45-47	immunoglobulin binding protein 1	Homo sapiens	134-142
9210297-0	1997	1H NMR analysis of novel sialylated and fucosylated lactose-based oligosaccharides having linear GlcNAc(beta 1-6) Gal and Neu5Ac(alpha 2-6) GlcNAc sequences.	Hydrogen	0-2	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	104-112
9210297-0	1997	1H NMR analysis of novel sialylated and fucosylated lactose-based oligosaccharides having linear GlcNAc(beta 1-6) Gal and Neu5Ac(alpha 2-6) GlcNAc sequences.	Hydrogen	0-2	immunoglobulin binding protein 1	Homo sapiens	129-138
9132024-0	1997	Evidence that cobalt-carbon bond homolysis is coupled to hydrogen atom abstraction from substrate in methylmalonyl-CoA mutase.	Hydrogen	57-65	methylmalonyl-CoA mutase	Homo sapiens	101-125
9132024-7	1997	These results suggest that Co-C bond homolysis is coupled to hydrogen atom abstraction from the substrate and that the intrinsic binding energy of substrate may be a significant contributor to catalysis by methylmalonyl-CoA mutase.	Hydrogen	61-69	methylmalonyl-CoA mutase	Homo sapiens	206-230
9020168-0	1997	Molecular characterization of GCV3, the Saccharomyces cerevisiae gene coding for the glycine cleavage system hydrogen carrier protein.	Hydrogen	109-117	glycine decarboxylase subunit H	Saccharomyces cerevisiae S288C	30-34
9032080-21	1997	In cytochrome c4, the hydrogen-bond network (between residues that are conserved in all known cytochrome c4 subspecies) seems to provide an efficient pathway for an intramolecular electron transfer that can ensure cooperativity between the two redox centres.	Hydrogen	22-30	cytochrome c3 family protein	Pseudomonas stutzeri	3-15
9063871-1	1997	This paper reports a detailed conformational analysis by 1H NMR (DMSO-d6, 300 K) and molecular modeling of the octapeptide D-Phe1-Cys2-Phe3-D-Trp4-Lys5-Thr6-Cys7+ ++-Thr8-ol (disulfide bridged) known as sandostatin (or SMS 201-995 or octreotide) with both somatostatin-like and opioid-like bioactivities.	Hydrogen	57-59	transient receptor potential cation channel subfamily C member 4	Homo sapiens	142-146
8954101-3	1996	Crosslinking was strongest to the 3" side of the CArG box, and to the outer rather than the inner CArG box guanines, consistent with hydrogen bonds formed between SRF and the outer guanines in the crystal structure [Pellegrini et al., Nature 376, 490, 1995].	Hydrogen	133-141	serum response factor	Homo sapiens	163-166
8985785-6	1996	This low energy conformation (analogous to a fragment of thymidylate synthase, 2TSC) of bombesin stabilized by five internal hydrogen bonds, and with the side chains of residues Trp8 and Leu13 held on the same side of the peptide, is in agreement with the experimentally observed data.	Hydrogen	125-133	gastrin releasing peptide	Homo sapiens	88-96
9008361-0	1996	Sequential assignment of 1H, 13C and 15N resonances of human carbonic anhydrase I by triple-resonance NMR techniques and extensive amino acid-specific 15N-labeling.	Hydrogen	25-27	carbonic anhydrase 1	Homo sapiens	61-81
8976559-0	1996	Significant hydrogen exchange protection in GroEL-bound DHFR is maintained during iterative rounds of substrate cycling.	Hydrogen	12-20	heat shock protein family D (Hsp60) member 1	Homo sapiens	44-49
8976559-2	1996	Here we describe the conformational properties of human dihydrofolate reductase (DHFR) bound to GroEL at different stages of its ATP-driven folding reaction, determined by hydrogen exchange labeling and electrospray ionization mass spectrometry.	Hydrogen	172-180	heat shock protein family D (Hsp60) member 1	Homo sapiens	96-101
8976559-3	1996	Considerable protection involving about 20 hydrogens is observed in DHFR bound to GroEL in the absence of ATP.	Hydrogen	43-52	heat shock protein family D (Hsp60) member 1	Homo sapiens	82-87
8888728-1	1996	Hydrogen breath tests (H2-BT) are commonly used to diagnose carbohydrate malabsorption.	Hydrogen	0-8	H2B clustered histone 20, pseudogene	Homo sapiens	23-28
8757924-2	1996	Sequential assignments are presented for 1H NMR resonances of the N-terminal residues Asp1, Ala2 and His3 of human serum albumin (HSA).	Hydrogen	41-43	beta-secretase 2	Homo sapiens	86-90
8819159-10	1996	A molecule of the precipitating agent dioxane is bound in a crystal contact, forming a hydrogen bond with Trp 32.	Hydrogen	87-95	thioredoxin like 1	Homo sapiens	106-112
8641177-6	1996	Bafilomycin A, a specific inhibitor of ATP-dependent hydrogen ion pumps, also inhibited IGFBP-3 potentiation of IGF-I-stimulated [3H]AIB uptake.	Hydrogen	53-61	IGFI	Bos taurus	112-117
8724421-0	1996	Determination of 1H relaxation times of water in human bone marrow by fat-suppressed turbo spin echo in comparison to MR spectroscopic methods.	Hydrogen	17-19	spindlin 1	Homo sapiens	91-95
8632452-3	1996	The solution structure of CRIP has been determined by homonuclear and 1H-15N heteronuclear correlated nuclear magnetic resonance spectroscopy.	Hydrogen	70-72	cysteine rich protein 2	Homo sapiens	26-30
8652624-5	1996	This was investigated by measuring the 1H-NMR spectra of synthetic peptides analogous to this region of MBP, both containing histidine but with and without the N-terminal half.	Hydrogen	39-41	myelin basic protein	Rattus norvegicus	104-107
8652571-1	1996	Peptide hydrogen exchange is measured in bovine pancreatic trypsin inhibitor (BPTI) by 2D NMR in KCl solutions varying between 0.02 and 0.43 M. The effects of salt are analyzed for 16 assigned peptide groups located near the protein-solvent interface in the crystal structure.	Hydrogen	8-16	spleen trypsin inhibitor I	Bos taurus	41-76
8652571-1	1996	Peptide hydrogen exchange is measured in bovine pancreatic trypsin inhibitor (BPTI) by 2D NMR in KCl solutions varying between 0.02 and 0.43 M. The effects of salt are analyzed for 16 assigned peptide groups located near the protein-solvent interface in the crystal structure.	Hydrogen	8-16	spleen trypsin inhibitor I	Bos taurus	78-82
8652590-3	1996	The lower axial ligand to the cobalt in free methylcobalamin is the dimethylbenzimidazole nucleotide substituent of the corrin ring; when methylcobalamin binds to methionine synthase, the ligand is replaced by histidine 759, which in turn is linked by hydrogen bonds to aspartate 757 and thence to serine 810.	Hydrogen	252-260	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	163-182
8636224-10	1996	Alternatively, inverse glycanation-apical sorting relationships in glypican may insure near constant deliveries of HS to the apical compartment, or "active" GPI-mediated entry of heparan sulfate into apical membrane compartments may require the overriding of this antagonizing effect of the heparan sulfate chains.	Hydrogen	115-117	glypican 1	Homo sapiens	67-75
8723315-4	1996	We isolated uniformly 15N labeled 56 amino acid wild-type (HP56WT) and 64 residue mutant [Pro3 &gt; Tyr3] (HP64tyr3) lac repressor N-terminal DNA binding fragments for 1H/15N NMR studies with the left and right operators separately.	Hydrogen	168-170	pyrroline-5-carboxylate reductase 1	Homo sapiens	90-94
8846787-5	1995	Here we describe the solution structure of the XNF7 B-box zinc-binding domain determined at physiological pH by 1H NMR methods.	Hydrogen	112-114	Nuclear factor 7 L homeolog	Xenopus laevis	47-51
7489704-3	1995	The amino-terminal domain binds in a substrate-like manner to the narrow active-site cleft of thrombin; the imidazole group of the P1 His residue extends into the S1 pocket to form favourable hydrogen/ionic bonds with Asp189 at its bottom, and additionally with Glu192 at its entrance.	Hydrogen	192-200	coagulation factor II, thrombin	Bos taurus	94-102
8521850-6	1995	Similar 1H chemical shifts were noted for several conserved residues in pNR-2/pS2 and pSP and a characteristic Phe residue with a slowly flipping ring was found in the pNR-2/pS2 variant and in both domains of pSP.	Hydrogen	8-10	microseminoprotein beta	Homo sapiens	86-89
8521850-6	1995	Similar 1H chemical shifts were noted for several conserved residues in pNR-2/pS2 and pSP and a characteristic Phe residue with a slowly flipping ring was found in the pNR-2/pS2 variant and in both domains of pSP.	Hydrogen	8-10	microseminoprotein beta	Homo sapiens	209-212
8590002-8	1995	The structure of the Abl SH(32) dual domain was characterized by NMR spectroscopy using the 1H and 15N resonance assignment of Abl SH3 and Abl SH2.	Hydrogen	92-94	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	21-24
8590003-8	1995	Analysis of line broadening and disappearance of crosspeaks in a 1H-15N correlation spectrum of the Mu Ner-DNA complex suggests that residues in these two helices are most likely to be in contact with the DNA.	Hydrogen	65-67	helix-turn-helix domain-containing protein	Escherichia phage D108	103-106
7563081-6	1995	The single turn of helical structure between residues Asp7 and Glu11 is stabilized by hydrogen bonds from the side-chain carboxylate of Asp7 to the exposed backbone NH groups of Ala10 and/or Leu9 (N-capping), and by hydrogen bonds between the exposed backbone carbonyl groups of residues Phe8 and Leu9, and the backbone NH groups of Gly12/Val12 and Gly13 (C-capping).	Hydrogen	86-94	CD7 molecule	Homo sapiens	297-301
7563081-6	1995	The single turn of helical structure between residues Asp7 and Glu11 is stabilized by hydrogen bonds from the side-chain carboxylate of Asp7 to the exposed backbone NH groups of Ala10 and/or Leu9 (N-capping), and by hydrogen bonds between the exposed backbone carbonyl groups of residues Phe8 and Leu9, and the backbone NH groups of Gly12/Val12 and Gly13 (C-capping).	Hydrogen	216-224	CD7 molecule	Homo sapiens	297-301
8595067-1	1995	PGHS (cyclooxygenase, prostaglandin endoperoxide synthase, 8.11,14-icosatrienoate hydrogen donor oxygen oxidoreductase, EC 1.14.99.1) is a bifunctional, membrane-bound hemoprotein that catalyzes both the bisoxygenation of arachidonic acid to form PGG2 and the peroxidative reduction of PGG2 to form PGH2.	Hydrogen	82-90	thioredoxin reductase 1	Homo sapiens	104-118
8589606-1	1995	The 1H, 13C and 15N NMR assignments of the backbone and side-chain resonances of rat S100 beta were made at pH 6.5 and 37 degrees C using heteronuclear multidimensional NMR spectroscopy.	Hydrogen	4-6	S100 calcium binding protein B	Rattus norvegicus	85-94
7582896-7	1995	The solution structure of the major conformer of AP-B has been determined by two-dimensional 1H NMR at pH 4.5 and 25 degrees C. The core structure is a four-stranded, antiparallel beta-sheet (residues 2-4, 20-23, 34-37 and 45-48) and includes several beta-turns (6-9, 25-28, 30-33).	Hydrogen	93-95	arginyl aminopeptidase	Homo sapiens	49-53
8535286-0	1995	1H NMR studies of peptide fragments from the N-terminus of chicken and human transthyretin.	Hydrogen	0-2	transthyretin	Homo sapiens	77-90
8637854-8	1995	The hydrogen bonding pattern of the catalytic triad of the double mutant is very similar to that of pancreatic lipase.	Hydrogen	4-12	pancreatic lipase	Homo sapiens	100-117
7626622-6	1995	The conserved sequence contains a tyrosine residue (Tyr-44) which, based on the X-ray crystal structure of ferredoxin-NADP+ reductase, is postulated to participate in FAD binding through van der Waals contact with the isoalloxazine ring and a hydrogen bond to the 3"-hydroxy of the ribityl moiety.	Hydrogen	243-251	FA complementation group D2	Homo sapiens	167-170
7558592-1	1995	Pseudo-C5-type intramolecular hydrogen bonding, arising from the C2 disposition of the core NH-CO-CO-NH unit in oxalo retro-peptides, is formed in addition to extended hydrogen bonding with neighbors forming sheets in MeO-Aib-COCO-Aib-OMe (1), helices in MeO-Leu-COCO-Leu-OMe (2) and ribbons in MeO-Ser-Leu-COCO-Leu-Ser-OMe (3).	Hydrogen	30-38	ANIB1	Homo sapiens	222-225
7558592-1	1995	Pseudo-C5-type intramolecular hydrogen bonding, arising from the C2 disposition of the core NH-CO-CO-NH unit in oxalo retro-peptides, is formed in addition to extended hydrogen bonding with neighbors forming sheets in MeO-Aib-COCO-Aib-OMe (1), helices in MeO-Leu-COCO-Leu-OMe (2) and ribbons in MeO-Ser-Leu-COCO-Leu-Ser-OMe (3).	Hydrogen	30-38	ANIB1	Homo sapiens	231-234
7670371-2	1995	The 1H, 15N, and 13C NMR chemical shift values for TnC in the presence of TFE are very similar to values obtained for calcium-saturated NTnC (residues 1-90 of skeletal TnC), calmodulin, and synthetic peptide homodimers.	Hydrogen	4-6	tenascin C	Homo sapiens	51-54
7540212-6	1995	These studies demonstrate the importance of the two hydrophobic cores composed largely of clusters of aromatic residues, as well as the internal hydrogen-bonding network, in stabilizing BPTI.	Hydrogen	145-153	spleen trypsin inhibitor I	Bos taurus	186-190
7729524-0	1995	Assignment of the backbone 1H,15N,13C NMR resonances and secondary structure of a double-stranded RNA binding domain from the Drosophila protein staufen.	Hydrogen	27-29	staufen	Drosophila melanogaster	145-152
7717990-4	1995	Binding of fluorescent lysophospholipids was enhanced with the FABP mutant, R122Q, possibly due to increased flexibility of the binding cavity as a result of reduced hydrogen-bonding constraints.	Hydrogen	166-174	fatty acid binding protein 2	Rattus norvegicus	63-67
7703697-9	1995	As a consequence, the important conserved hydrogen bonding network which is also seen in the crystal structures is present only in the ternary complex, but not in free PLA2.	Hydrogen	42-50	phospholipase A2 group IIA	Homo sapiens	168-172
7538845-4	1994	Essentially the same amide hydrogens are protected from exchange in both of the BPTI variants studied here as in native BPTI, demonstrating that the variants adopt fully folded, native-like structures in solution.	Hydrogen	27-36	spleen trypsin inhibitor I	Bos taurus	80-84
7961960-0	1994	A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity.	Hydrogen	16-24	solute carrier family 9 member A4	Rattus norvegicus	43-48
7961960-7	1994	We conclude that NHE-4 is an unusual isoform of sodium-hydrogen exchangers that may play a specialized supplementary role in cell volume regulation.	Hydrogen	55-63	solute carrier family 9 member A4	Rattus norvegicus	17-22
7726999-2	1994	The influence of low temperature and high viscosity on the conformation of somatostatin and two of its analogues was investigated by 1H NMR in solution.	Hydrogen	133-135	somatostatin	Homo sapiens	75-87
7817767-4	1994	The reaction of 2 with cis-2-hydroxymethylcyclohexylamine gave the tetracyclic (8), while 2 and diendo-3-hydroxymethylbicyclo[2.2.1]hept-5-enyl-2-amine yielded the isomers (9a,b), which differ in the mutual positions of the phenyl group on the quaternary carbon and cyclohexane annelation hydrogens.	Hydrogen	289-298	suppressor of cytokine signaling 2	Homo sapiens	23-28
7868051-11	1994	Acute cold exposure (5 degrees C/1h) enhanced GDP binding in WC, resting CA and ICE resting, but the degree of increment was greater in CA and ICE than in WC.	Hydrogen	33-35	caspase 1	Rattus norvegicus	80-83
7868051-11	1994	Acute cold exposure (5 degrees C/1h) enhanced GDP binding in WC, resting CA and ICE resting, but the degree of increment was greater in CA and ICE than in WC.	Hydrogen	33-35	caspase 1	Rattus norvegicus	143-146
7809021-4	1994	The purpose of this study was to examine the effect of BBS on the growth of H2T tumors transplanted into athymic nude mice.	Hydrogen	76-78	gastrin releasing peptide	Homo sapiens	55-58
8078492-11	1994	In addition, a hydrogen bond is formed from the phenolic hydrogen of the agonist ligands to Ser-193 (TM 5).	Hydrogen	15-23	tropomyosin 3	Homo sapiens	101-105
8078492-11	1994	In addition, a hydrogen bond is formed from the phenolic hydrogen of the agonist ligands to Ser-193 (TM 5).	Hydrogen	57-65	tropomyosin 3	Homo sapiens	101-105
8027057-1	1994	The catalysis of the hydration of CO2 by human carbonic anhydrase II (HCA II) includes the transfer of a proton from zinc-bound water to histidine 64 utilizing a network of intervening hydrogen-bonded water molecules, then the proton is transferred to buffer in solution.	Hydrogen	185-193	carbonic anhydrase 2	Homo sapiens	47-68
7981420-6	1994	An autoxidative pyrrole dimer containing a methylene bridge between C-2 of one pyrrole ring and C-3 of a second ring was characterized by thermospray MS and 1H-NMR spectroscopy.	Hydrogen	157-159	complement C3	Homo sapiens	96-99
7909804-2	1994	The solution conformations of RC-160, cyclic D-Phe1-Cys2-Tyr3-D-Trp4-Lys5-Val6-Cys7+ ++-Trp8-NH2, an analog of the tumor antiproliferatory neuropeptide somatostatin, and RC-160 labeled with rhenium (Re-RC-160), have been determined by using two-dimensional 1H NMR spectroscopy (600 MHz) and restrained molecular dynamics simulations.	Hydrogen	257-259	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	69-73
8134374-3	1994	We have determined the complete three-dimensional solution structure of pSP by using a combination of two- and three-dimensional 1H NMR spectroscopy and distance geometry calculations.	Hydrogen	129-131	microseminoprotein beta	Homo sapiens	72-75
8187244-2	1994	The ePgn/K4 was investigated as a complex with epsilon-aminocaproic acid, an antifibrinolytic drug, by two-dimensional 1H-NMR spectroscopy at 500 MHz.	Hydrogen	119-121	epithelial mitogen	Equus caballus	4-8
8262987-0	1993	Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.	Hydrogen	52-60	carbonic anhydrase 2	Homo sapiens	83-104
8262987-1	1993	Amino acid substitutions at Thr199 of human carbonic anhydrase II (CAII) (Thr199--&gt;Ser, Ala, Val, and Pro) were characterized to investigate the importance of a conserved hydrogen bonding network.	Hydrogen	174-182	carbonic anhydrase 2	Homo sapiens	44-65
8262987-1	1993	Amino acid substitutions at Thr199 of human carbonic anhydrase II (CAII) (Thr199--&gt;Ser, Ala, Val, and Pro) were characterized to investigate the importance of a conserved hydrogen bonding network.	Hydrogen	174-182	carbonic anhydrase 2	Homo sapiens	67-71
8262987-6	1993	These data are consistent with the hydroxyl group of Thr199 forming a hydrogen bond with the transition state and a non-hydrogen-bonded van der Waals contact with CAII.HCO3-.	Hydrogen	120-128	carbonic anhydrase 2	Homo sapiens	163-167
7504737-1	1993	The conformational properties of seven overlapping peptides, 9 to 16 residues long, that comprise the entire primary structure of bovine pancreatic trypsin inhibitor (BPTI) have been characterized by circular dichroism and 1H nuclear magnetic resonance.	Hydrogen	223-225	spleen trypsin inhibitor I	Bos taurus	130-165
8106273-6	1993	Synthesis of IL-1 alpha, TCR, CD4, and CD8 was restored by addition of HS to the cultured organs.	Hydrogen	71-73	CD4 antigen	Mus musculus	30-33
8405445-2	1993	Each analog with hydrogen, methyl, ethyl, isopropyl, isobutyl, tert-butyl, and isoamyl group on C-3 functions as a substrate, implying a broad substrate specificity of the enzyme toward alkylmalates.	Hydrogen	17-25	complement C3	Homo sapiens	96-99
7690588-1	1993	The hydrogen isotope exchange kinetics of buried NH protons in bovine pancreatic trypsin inhibitor (BPTI) was measured in 8 M urea at 30 degrees C and pH 3.5.	Hydrogen	4-12	spleen trypsin inhibitor I	Bos taurus	100-104
8214607-1	1993	Electrochemical reduction of H2O2 at pyrolytic graphite disc electrodes of radius 2.5 mm occurs at readily accessible potentials (600 mV versus the standard hydrogen electrode) in the presence of yeast cytochrome c peroxidase.	Hydrogen	157-165	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	202-225
8393472-3	1993	Chronic decreases in extracellular fluid pH cause an increase in Na/H antiporter activity that is dependent on protein synthesis and associated with an increase in NHE-1 (isoform of the sodium-hydrogen antiporter) mRNA abundance.	Hydrogen	193-201	sodium/hydrogen exchanger 1	Oryctolagus cuniculus	164-169
9909775-0	1993	Spin asymmetry in resonant electron-hydrogen elastic scattering.	Hydrogen	36-44	spindlin 1	Homo sapiens	0-4
8331663-1	1993	A portion of human complement factor H spanning the 15th (H15) and 16th (H16) of its 20 modules, has been expressed in a yeast vector and subjected to structure determination in solution using two-dimensional 1H-NMR.	Hydrogen	209-211	complement factor H	Homo sapiens	19-38
8515458-2	1993	The syn CO and NH groups of these amide groups are hydrogen-bonded to the main-chain NH and CO groups of other amino acid residues.	Hydrogen	51-59	synemin	Homo sapiens	4-7
8097478-0	1993	Secondary structure of the oct-3 POU homeodomain as determined by 1H-15N NMR spectroscopy.	Hydrogen	66-68	POU domain, class 5, transcription factor 1	Mus musculus	27-32
8097478-1	1993	Most of the 1H and 15N magnetic resonances of the 66 amino acid long POU homeodomain of mouse Oct-3 have been assigned by the combined use of the two-dimensional homonuclear, and two- and three-dimensional heteronuclear NMR methods.	Hydrogen	12-14	POU domain, class 5, transcription factor 1	Mus musculus	94-99
8478901-8	1993	The addition of Ca2+ to a solution of verapamil in acetonitrile caused marked changes in the difference absorbance of the drug in the 200-300-nm region and in many of its 1H-NMR resonances.	Hydrogen	171-173	carbonic anhydrase 2	Homo sapiens	16-19
8443156-1	1993	Almost complete assignments of the 1H, 15N, and aliphatic 13C resonances of the 62-residue N-terminal DNA-binding domain of GAL4 [GAL4(62)] have been obtained using a combination of two-dimensional homonuclear and two- and three-dimensional double- and triple-resonance heteronuclear NMR methods.	Hydrogen	35-37	galectin 4	Homo sapiens	124-128
8443156-1	1993	Almost complete assignments of the 1H, 15N, and aliphatic 13C resonances of the 62-residue N-terminal DNA-binding domain of GAL4 [GAL4(62)] have been obtained using a combination of two-dimensional homonuclear and two- and three-dimensional double- and triple-resonance heteronuclear NMR methods.	Hydrogen	35-37	galectin 4	Homo sapiens	130-138
8443156-6	1993	Preliminary structure calculations using a subset of distance restraints derived from three-dimensional 1H-15N and 1H-13C NOESY-HSQC spectra are consistent with the recently reported solution structures of Zn(II)2GAL4(7-49) [Kraulis, P., et al.	Hydrogen	104-106	galectin 4	Homo sapiens	206-217
8443156-6	1993	Preliminary structure calculations using a subset of distance restraints derived from three-dimensional 1H-15N and 1H-13C NOESY-HSQC spectra are consistent with the recently reported solution structures of Zn(II)2GAL4(7-49) [Kraulis, P., et al.	Hydrogen	115-117	galectin 4	Homo sapiens	206-217
8444178-1	1993	1H spin-echo and 31P-NMR evidence for lysophospholipase.	Hydrogen	0-2	phospholipase A2 group IVA	Homo sapiens	38-55
7680380-2	1993	An analogue of the important folding intermediate of BPTI with only the disulphide bond between Cys30 and Cys51 has been characterized by 1H and 15N NMR techniques.	Hydrogen	138-140	spleen trypsin inhibitor I	Bos taurus	53-57
8095405-2	1993	Two forms of parvalbumin, i.e., the fully Ca-loaded form PaCa2 and the fully Mg-loaded form PaMg2, are investigated by 2D 1H NMR in solution.	Hydrogen	122-124	parvalbumin	Homo sapiens	13-24
8443588-8	1993	Backbone amide protons of Phe4 and Ala13 and the backbone carbonyl oxygen of Lys2 that lie within this cleft appear to form hydrogen bonds with the guanosine O6 and N1H atoms, respectively.	Hydrogen	124-132	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	77-81
1287652-4	1992	Even for serine and threonine side chains only two minimum energy sites are found in general of which one is in an expected position within hydrogen bonding of the hydroxyl hydrogen atom (unless this is blocked from interaction with solvent molecules by, for example, Oi-4 or Oi-3.	Hydrogen	140-148	collagen type I alpha 1 chain	Homo sapiens	276-280
1287652-4	1992	Even for serine and threonine side chains only two minimum energy sites are found in general of which one is in an expected position within hydrogen bonding of the hydroxyl hydrogen atom (unless this is blocked from interaction with solvent molecules by, for example, Oi-4 or Oi-3.	Hydrogen	173-181	collagen type I alpha 1 chain	Homo sapiens	276-280
1304891-0	1992	A 1H NMR study of a ternary peptide complex that mimics the interaction between troponin C and troponin I.	Hydrogen	2-4	tenascin C	Homo sapiens	80-90
1332764-3	1992	Measurement of transferred NOEs and molecular modeling indicate that the side chain of the Asp(P3) residue may form a hydrogen bond with thrombin and, by doing so, it is brought near a positively-charged thrombin residue Arg(221A), thereby partially neutralizing the negative charge of an Asp residue at this site of protein substrates.	Hydrogen	118-126	coagulation factor II, thrombin	Bos taurus	137-145
1445892-1	1992	The conformation and amide hydrogen exchangeability of the hydrophobic peptide Lys2-Gly-Leu24-Lys2-Ala-amide were studied by Fourier transform infrared spectroscopy.	Hydrogen	27-35	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	79-83
1445892-1	1992	The conformation and amide hydrogen exchangeability of the hydrophobic peptide Lys2-Gly-Leu24-Lys2-Ala-amide were studied by Fourier transform infrared spectroscopy.	Hydrogen	27-35	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	94-98
1331071-7	1992	Binding is mediated by a two-prong electrostatic and hydrogen-binding interaction via arginines B13 and B17.	Hydrogen	53-61	NADH:ubiquinone oxidoreductase subunit B6	Homo sapiens	104-107
1629626-5	1992	Four amino acid replacements, resulting in a net positive change in non-hydrogen atoms in the S1" subsite of MC-CPA, were associated with less alteration in substrate specificity, relative to bovine CPA, than might be expected from studies using rat CPA1 and CPA2.	Hydrogen	72-80	carboxypeptidase A1	Rattus norvegicus	250-254
10003882-0	1992	Trap-limited hydrogen diffusion in boron-doped silicon.	Hydrogen	13-21	TRAP	Homo sapiens	0-4
1374641-0	1992	Comparison of hydrogen exchange rates for bovine pancreatic trypsin inhibitor in crystals and in solution.	Hydrogen	14-22	spleen trypsin inhibitor I	Bos taurus	42-77
1374641-1	1992	Hydrogen exchange rate constants for the 17 slowest exchanging amide NH groups in bovine pancreatic trypsin inhibitor (BPTI) were measured in solution and in form II and form III crystals.	Hydrogen	0-8	spleen trypsin inhibitor I	Bos taurus	82-117
1374641-1	1992	Hydrogen exchange rate constants for the 17 slowest exchanging amide NH groups in bovine pancreatic trypsin inhibitor (BPTI) were measured in solution and in form II and form III crystals.	Hydrogen	0-8	spleen trypsin inhibitor I	Bos taurus	119-123
1374641-5	1992	One consists of the 10 slowest exchanging hydrogens, all of which are associated with the central beta-sheet of BPTI.	Hydrogen	42-51	spleen trypsin inhibitor I	Bos taurus	112-116
1556190-3	1992	Hydrogen consumption varied directly with PH2, and methanogenic feces consumed H2 far more rapidly than did nonmethanogenic feces.	Hydrogen	0-8	polyhomeotic homolog 2	Homo sapiens	42-45
1556190-4	1992	At low PH2, H2 production greatly exceeded consumption and there was negligible accumulation of the products of H2 catabolism, methane and sulfide.	Hydrogen	12-14	polyhomeotic homolog 2	Homo sapiens	7-10
1556190-8	1992	We conclude that most H2 produced by colonic bacteria is consumed and methanogenesis and fecal stirring (via its influence on fecal PH2) are critical determinants of H2 consumption and, hence, net H2 production.	Hydrogen	22-24	polyhomeotic homolog 2	Homo sapiens	132-135
1544495-2	1992	After the assignment of 1H NMR signals of aromatic side chains by means of specific deuteration, we analyzed the DNA binding site of GAL4 by measuring photo-CIDNP spectra.	Hydrogen	24-26	galectin 4	Homo sapiens	133-137
1532695-11	1992	Atrial natriuretic peptide (ANP) gradually increased throughout the 5 wk from 86 +/- 22 (1H) to 709 +/- 217 pg/ml (5W).	Hydrogen	89-91	natriuretic peptide A	Rattus norvegicus	0-26
1532695-11	1992	Atrial natriuretic peptide (ANP) gradually increased throughout the 5 wk from 86 +/- 22 (1H) to 709 +/- 217 pg/ml (5W).	Hydrogen	89-91	natriuretic peptide A	Rattus norvegicus	28-31
1737002-2	1992	Extensive 1H and 15N resonance assignments of calmodulin in the complex have been obtained from the analysis of two- and three-dimensional nuclear magnetic resonance spectra.	Hydrogen	10-12	calmodulin 2	Gallus gallus	46-56
1737002-5	1992	The pattern of nuclear Overhauser effects (NOE) seen among main-chain amide NH, C alpha H, and C beta H hydrogens indicates that the secondary structure of the globular domains of calmodulin in the complex closely corresponds to that observed in the calcium-saturated state of the protein in the absence of bound peptide.	Hydrogen	104-113	calmodulin 2	Gallus gallus	180-190
1819586-2	1991	Boc-Aib-Ac7c-NHMe and Boc-Pro-Ac7c-Ala-OMe adopt beta-turn conformations stabilized by an intramolecular 4----1 hydrogen bond, the former folding into a type-I/III beta-turn and the latter into a type-II beta-turn.	Hydrogen	112-120	ANIB1	Homo sapiens	4-7
1928091-5	1991	His-107 appears to have a stabilizing function in the structure of all CA molecules, and its substitution by Tyr apparently disrupts the critical hydrogen bonding of His-107 to two other similarly invariant residues, Glu-117 and Tyr-194, resulting in an unstable CA II molecule.	Hydrogen	146-154	carbonic anhydrase 2	Homo sapiens	263-268
1931970-7	1991	All of the crucial amino acid residues are conserved in human GPT, which seem to be hydrogen bonding to pyridoxal 5"-phosphate in rat GPT by the sequence homology to other alpha-aminotransferases with known tertiary structures.	Hydrogen	84-92	glutamic--pyruvic transaminase	Rattus norvegicus	134-137
1888740-5	1991	A strong hydrogen bond is postulated to exist between amide carbonyl group of NAD+ and the enzyme in the binary complexes with both mMDH and sMDH on the basis of a sizable decrease in the frequency of the carbonyl double bond.	Hydrogen	9-17	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	132-136
1888740-8	1991	Surprisingly, the hydrogen bond to the -NH2 group in mMDH is the same as that found for water.	Hydrogen	18-26	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	53-57
1893530-2	1991	Two conformations for the methyl group in O6MeGua are possible: in one the methyl group is syn with respect to the N(1)-position of the purine, points into the helix, and disrupts hydrogen bonding potential; in the second the methyl group is anti with respect to the N1-position of the purine, and points into the major groove.	Hydrogen	180-188	synemin	Homo sapiens	91-94
1804549-5	1991	On the other hand, hydroperoxidation of Rb1 occurred in rat stomach; the major hydroperoxide was separated and identified as the 25-hydroperoxy-23-ene derivative of Rb1 (VIII) by 1H- and 13C-nuclear magnetic resonance and fast atom bombardment mass spectrometry.	Hydrogen	179-181	RB transcriptional corepressor 1	Rattus norvegicus	165-168
1883821-0	1991	Probing the relationship between alpha-helix formation and calcium affinity in troponin C: 1H NMR studies of calcium binding to synthetic and variant site III helix-loop-helix peptides.	Hydrogen	91-93	tenascin C	Homo sapiens	79-89
1715671-6	1991	The changes in mucus gel mucin content with sucralfate were accompanied by a 9.5% increase in mucus hydrogen ion (H+) retardation capacity, 1.9-fold increase in viscosity, and a 60% increase in the gel hydrophobicity.	Hydrogen	100-108	solute carrier family 13 member 2	Rattus norvegicus	25-30
1714958-4	1991	An X-ray diffraction study has revealed that the glycosidic torsion angle of the nucleoside is in the less common syn region and this solid-state geometry is stabilized by a three-dimensional network of self-associated hydrogen-bonded molecules.	Hydrogen	219-227	synemin	Homo sapiens	114-117
2067016-1	1991	1H nuclear magnetic resonance studies of (Cd2+)1-bovine calbindin D9k.	Hydrogen	0-2	complement C3d receptor 2	Bos taurus	42-48
2067016-5	1991	Virtually complete 1H resonance assignments have been obtained for both the (Cd2+)1 and the (Cd2+)2 states.	Hydrogen	19-21	complement C3d receptor 2	Bos taurus	77-83
1793852-3	1991	The following observations indicate that the process is essentially the chain reaction: 1) The amount of the methemoglobin in haem groups, produced in the reaction, exceed by 20 times the quantity of hydrogen, added initially, to induce the oxidation.	Hydrogen	200-208	hemoglobin subunit gamma 2	Homo sapiens	109-122
2021614-0	1991	Sequential assignments of the 1H NMR resonances of Zn(II)2 and 113Cd(II)2 derivatives of the DNA-binding domain of the GAL4 transcription factor reveal a novel structural motif for specific DNA recognition.	Hydrogen	30-32	galectin 4	Homo sapiens	119-123
2015821-0	1991	Structure determination of the glycans of human-serum alpha 1-antichymotrypsin using 1H-NMR spectroscopy and deglycosylation by N-glycanase.	Hydrogen	85-87	serpin family A member 3	Homo sapiens	54-78
1993197-7	1991	The energy-minimized conformation of the central d(G4-G5-G6).d(C13-epsilon A14-C15) segment establishes that the dG5(anti).epsilon dA14(syn) alignment is stabilized by two hydrogen bonds from the NH1 and NH2-2 of dG5(anti) to N9 and N1 of epsilon dA14(syn), respectively.	Hydrogen	172-180	placenta associated 8	Homo sapiens	63-82
1993197-7	1991	The energy-minimized conformation of the central d(G4-G5-G6).d(C13-epsilon A14-C15) segment establishes that the dG5(anti).epsilon dA14(syn) alignment is stabilized by two hydrogen bonds from the NH1 and NH2-2 of dG5(anti) to N9 and N1 of epsilon dA14(syn), respectively.	Hydrogen	172-180	synemin	Homo sapiens	136-139
1993197-7	1991	The energy-minimized conformation of the central d(G4-G5-G6).d(C13-epsilon A14-C15) segment establishes that the dG5(anti).epsilon dA14(syn) alignment is stabilized by two hydrogen bonds from the NH1 and NH2-2 of dG5(anti) to N9 and N1 of epsilon dA14(syn), respectively.	Hydrogen	172-180	synemin	Homo sapiens	252-255
1993202-0	1991	1H NMR study of the role of heme carboxylate side chains in modulating heme pocket structure and the mechanism of reconstitution of cytochrome b5.	Hydrogen	0-2	cytochrome b5 type A	Rattus norvegicus	132-145
2031955-1	1991	It has been shown that fructose metabolism in the human liver can be monitored quantitatively by means of 1H image-guided 31P MRS, implemented on a clinical MR imaging system equipped with surface coils and with appropriate data processing software.	Hydrogen	106-108	MROS	Homo sapiens	126-129
1657733-4	1991	The predominant spin adduct detected after ethanol treatment is proposed to be from a carbon-centered, primary alkyl radical, based on gamma-hydrogen hyperfine splitting patterns observed with PBN-d14.	Hydrogen	141-149	spindlin 1	Rattus norvegicus	16-20
2386810-2	1990	The repeating pentapeptide and hexapeptide sequences of elastin have been suggested to contain a type II beta-turn with a 4----1 hydrogen bond.	Hydrogen	129-137	elastin	Homo sapiens	56-63
2386810-3	1990	Depsipeptide analogues of the repeating sequences of elastin in which this 4----1 hydrogen bond cannot exist were synthesized.	Hydrogen	82-90	elastin	Homo sapiens	53-60
2386811-1	1990	In this work the effect of elimination of a specific hydrogen bond on the conformation of the repeating peptides of elastin was studied.	Hydrogen	53-61	elastin	Homo sapiens	116-123
2271574-0	1990	1H NMR studies of the glucocorticoid receptor DNA-binding domain: sequential assignments and identification of secondary structure elements.	Hydrogen	0-2	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	22-45
2271574-1	1990	Two protein fragments containing the DNA-binding domain (DBD) of the glucocorticoid receptor (GR) have been studied by two-dimensional 1H NMR spectroscopy.	Hydrogen	135-137	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	69-92
2271574-1	1990	Two protein fragments containing the DNA-binding domain (DBD) of the glucocorticoid receptor (GR) have been studied by two-dimensional 1H NMR spectroscopy.	Hydrogen	135-137	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	94-96
2271574-4	1990	More than 90% of all observable 1H resonances within a 71-residue segment encompassing C440-R510 (rat GR) could be sequentially assigned by standard techniques, and stereospecific assignments could be made for the methyl groups in four valine residues within this segment.	Hydrogen	32-34	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	102-104
2223783-1	1990	Nearly complete sequence-specific 1H NMR assignments are presented for amino acid residues 3-81 in the 81-residue globular activation domain of porcine pancreatic procarboxypeptidase B isolated after limited tryptic proteolysis of the zymogen.	Hydrogen	34-36	carboxypeptidase B1	Homo sapiens	163-184
2383556-0	1990	Sequence-specific 1H NMR assignments and secondary structure of porcine motilin.	Hydrogen	18-20	motilin	Homo sapiens	72-79
2383556-1	1990	The solution structure of the 22-residue peptide hormone motilin has been studied by circular dichroism and two-dimensional 1H nuclear magnetic resonance spectroscopy.	Hydrogen	124-126	motilin	Homo sapiens	57-64
2364068-0	1990	1H NMR study of rabbit skeletal muscle troponin C: Mg2(+)-induced conformational change.	Hydrogen	0-2	tenascin	Oryctolagus cuniculus	39-49
2364068-1	1990	Binding of Mg2+ to rabbit skeletal muscle troponin C (TnC) is studied by means of two-dimensional (2D) 1H NMR spectroscopy.	Hydrogen	103-105	tenascin	Oryctolagus cuniculus	42-52
2364068-1	1990	Binding of Mg2+ to rabbit skeletal muscle troponin C (TnC) is studied by means of two-dimensional (2D) 1H NMR spectroscopy.	Hydrogen	103-105	tenascin	Oryctolagus cuniculus	54-57
2107541-8	1990	1H NMR spectra of apo-GAL4(62*) suggest conformational fluctuation of the metal-binding subdomain upon removal of Zn(II) or Cd(II).	Hydrogen	0-2	galectin 4	Homo sapiens	22-26
2107541-9	1990	Both Cd(II)2- and Zn(II)2-containing species of GAL4 can be formed, and the similar 1H NMR spectra suggest similar conformations.	Hydrogen	84-86	galectin 4	Homo sapiens	48-52
2156693-4	1990	This fact implies the existence of non-linear hydrogen bonds inside the active site of adenosine deaminase.	Hydrogen	46-54	adenosine deaminase	Homo sapiens	87-106
2303058-1	1990	The conformation of bombesin in trifluoroethanol/water mixtures has been studied using 1H-NMR spectroscopy.	Hydrogen	87-89	gastrin releasing peptide	Homo sapiens	20-28
9993802-0	1990	Trap-limited hydrogen diffusion in doped silicon.	Hydrogen	13-21	TRAP	Homo sapiens	0-4
2296604-1	1990	The presence of multiple alpha,alpha-dialkyl amino acids such as alpha-methylalanine (alpha-aminoisobutyric acid, Aib) leads to predominantly helical structures, either with alpha-helical or 3(10)-helical hydrogen bonding patterns.	Hydrogen	205-213	ANIB1	Homo sapiens	114-117
33590347-4	2021	DA binds with Keap1 to form 3 stable hydrogen bonds at VAL512 and LEU557 and increased nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response elemen (ARE) luciferase activity.	Hydrogen	37-45	kelch-like ECH-associated protein 1	Mus musculus	14-19
33767761-0	2021	Hydrogen gas alleviates acute alcohol-induced liver injury by inhibiting JNK activation.	Hydrogen	0-8	mitogen-activated protein kinase 8	Mus musculus	73-76
33773191-13	2021	Molecular docking simulation further evidenced that DS-1 interacts with MDM2 within the p53-binding domain by carbon-hydrogen bond interaction at Lys27, pi-alkyl interactions at Ile37 and Leu30, and van der Waals interactions at Ile75, Val51, Val69, Phe67, Met38, Tyr43, Gly34, and Phe31.	Hydrogen	117-125	mitochondrial ribosomal protein L58	Homo sapiens	52-56
33773191-13	2021	Molecular docking simulation further evidenced that DS-1 interacts with MDM2 within the p53-binding domain by carbon-hydrogen bond interaction at Lys27, pi-alkyl interactions at Ile37 and Leu30, and van der Waals interactions at Ile75, Val51, Val69, Phe67, Met38, Tyr43, Gly34, and Phe31.	Hydrogen	117-125	MDM2 proto-oncogene	Homo sapiens	72-76
33940475-7	2021	Representative phenolic inhibitors induced mixed or competitive inhibition of PPO, mainly driven by hydrophobic forces and hydrogen bonds.	Hydrogen	123-131	polyphenol oxidase, chloroplastic	Malus domestica	78-81
33818445-2	2021	When electrolysis was performed for 10 minutes using a direct-current electrolytic hydrogen-water generating bottle with tap water, "residual free chlorine" concurrently upon the production of molecular hydrogen (444 mug/L) could be appreciably decreased from 0.18 mg/L to 0.12 mg/L as quantified by a N,N-diethyl-p-phenylenediamine-dye colorimetric method.	Hydrogen	83-91	nuclear RNA export factor 1	Homo sapiens	121-124
33818445-2	2021	When electrolysis was performed for 10 minutes using a direct-current electrolytic hydrogen-water generating bottle with tap water, "residual free chlorine" concurrently upon the production of molecular hydrogen (444 mug/L) could be appreciably decreased from 0.18 mg/L to 0.12 mg/L as quantified by a N,N-diethyl-p-phenylenediamine-dye colorimetric method.	Hydrogen	203-211	nuclear RNA export factor 1	Homo sapiens	121-124
33767697-10	2021	LPS-stimulated THP-1 and HUVEC-C cells in vitro and showed that hydrogen decreases TF expression and MMP-9 activity, which were abolished by the Trx1 inhibitor, PX12.	Hydrogen	64-72	matrix metallopeptidase 9	Homo sapiens	101-106
33767697-11	2021	Hydrogen attenuates endotoxin-induced lung injury by decreasing TF expression and MMP-9 activity via activating Trx1.	Hydrogen	0-8	matrix metallopeptidase 9	Homo sapiens	82-87
33786291-8	2021	The stability of the protein-ligand complexes of polymerase inhibitors considered in this investigation, such as Sofosbuvir, Remdesivir, Tenofovir, Ribavirin, Galidesivir, 5c3, 5h1 and 7a1, show strong to moderate hydrogen bonding and hydrophobic interactions (pi-pi stacked, pi-pi T-shaped, pi-sigma and pi-alkyl).	Hydrogen	214-222	ribavirin, galidesivir, 5c3, 5h1 and 7a1	None	148-188
34753075-4	2022	Systematic characterization suggested that Car was successfully encapsulated, and hydrogen bonding and hydrophobic interactions are the main forces facilitating the self-assembly and encapsulation.	Hydrogen	82-90	nuclear receptor subfamily 1 group I member 3	Homo sapiens	43-46
34689093-7	2022	The interaction binding mode of BTC with Ga3+ was proposed by HRMS, 1H NMR spectral titration, UV-vis absorption and fluorescence spectral measurements.	Hydrogen	68-70	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	41-44
34893208-3	2022	Due to the reduction of hydrogen bonding force inside A-cellulose and the high shear force provided by the extruder, acetylated cellulose nanofiber (A-CNF) distributed with the state of a three-dimensional network in PP composites (ACPP) were successful prepared.	Hydrogen	24-32	acid phosphatase 3	Homo sapiens	232-236
34487928-5	2022	When tested in 0.1 M phosphate buffer saline with 200 ppm NO2-, such Ni2P/NF is able to obtain a large NH3 yield rate of 2692.2 +- 92.1 mug h-1 cm-2 (3282.9 +- 112.3 mug h-1 mgcat.-1), a high Faradic efficiency of 90.2 +- 3.0%, and selectivity of 87.0 +- 1.7% at -0.3 V versus a reversible hydrogen electrode.	Hydrogen	290-298	neurofascin	Homo sapiens	74-76
34529349-11	2022	It exhibited a lower melting temperature, and increased hydrogen-deuterium exchange rates at residues near the secondary GPIbalpha-binding site and the N-terminal flanking sequence.	Hydrogen	56-64	glycoprotein Ib platelet subunit alpha	Homo sapiens	121-130
34967489-0	2022	Two-Dimensional-Polycyclic Photovoltaic Molecule with Low Trap Density for High-Performance Photocatalytic Hydrogen Evolution.	Hydrogen	107-115	TRAP	Homo sapiens	58-62
34967489-1	2022	Typical organic semiconductors show a high trap density of states (1016-1018 cm-3), providing a large number of centers for charge-carrier recombination, thus hindering the development of photocatalytic hydrogen evolution.	Hydrogen	203-211	TRAP	Homo sapiens	43-47
34658466-10	2021	This effect can be explained by the formation of hydrogen bonds between NF and GA in the middle of the bilayer.	Hydrogen	49-57	neurofascin	Homo sapiens	72-74
34851341-8	2021	Molecular docking showed that the majority binding energy of peptides-targets was between -10.35 kcal mol-1 and -18.72 kcal mol-1, and peptides mainly interacted with the core targets (Btk, Gstm1, and Rac1) by hydrogen-bonding interactions.	Hydrogen	210-218	Bruton tyrosine kinase	Homo sapiens	185-188
34822321-0	2021	The recycling regulation of sodium-hydrogen exchanger isoform 3(NHE3) in epithelial cells.	Hydrogen	35-43	solute carrier family 9 member A3	Homo sapiens	64-68
34822321-1	2021	As the main exchanger of electroneutral NaCl absorption, sodium-hydrogen exchanger isoform 3 (NHE3) circulates in the epithelial brush border (BB) and intracellular compartments in a multi-protein complex.	Hydrogen	64-72	solute carrier family 9 member A3	Homo sapiens	94-98
34485782-9	2021	The new intramolecular hydrogen bonds formed during the S-protein adsorption replace the S-protein-water hydrogen bonds; this trend though less apparent, is observed also during the relaxation of the free S-protein in water.	Hydrogen	23-31	vitronectin	Homo sapiens	56-65
34485782-9	2021	The new intramolecular hydrogen bonds formed during the S-protein adsorption replace the S-protein-water hydrogen bonds; this trend though less apparent, is observed also during the relaxation of the free S-protein in water.	Hydrogen	23-31	vitronectin	Homo sapiens	205-214
34485782-9	2021	The new intramolecular hydrogen bonds formed during the S-protein adsorption replace the S-protein-water hydrogen bonds; this trend though less apparent, is observed also during the relaxation of the free S-protein in water.	Hydrogen	105-113	vitronectin	Homo sapiens	56-65
34485782-9	2021	The new intramolecular hydrogen bonds formed during the S-protein adsorption replace the S-protein-water hydrogen bonds; this trend though less apparent, is observed also during the relaxation of the free S-protein in water.	Hydrogen	105-113	vitronectin	Homo sapiens	89-98
34937899-1	2021	Spin-ordered electronic states in hydrogen-terminated zigzag nanographene give rise to magnetic quantum phenomena1,2 that have sparked renewed interest in carbon-based spintronics3,4.	Hydrogen	34-42	spindlin 1	Homo sapiens	0-4
34884494-5	2021	The mechanism by which these drugs exert their cardioprotective effects is unknown, although recent studies have shown that cardiovascular homeostasis occurs through the interplay of the sodium-hydrogen exchangers (NHE), specifically NHE1 and NHE3, with SGLT2i.	Hydrogen	194-202	solute carrier family 9 member A3	Homo sapiens	243-247
34940412-4	2021	The results of the MBR-MBfR experiments indicated that a C/N ratio of two was suitable for NH4+-N, NO2--N, NO3--N, and chemical oxygen demand (COD) removal in partial nitrification-denitrification (PN-D) and hydrogen autotrophic denitrification for further treatment.	Hydrogen	208-216	translocator protein	Homo sapiens	19-22
34749386-5	2021	The detection mechanism of HT toward Ga3+ was proposed and confirmed by 1H NMR analysis, HRMS analysis, and DFT calculations.	Hydrogen	72-74	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	37-40
34726373-2	2021	Herein, an injectable, self-healing, and conductive chitosan-based (CPT) hydrogel with pH responsiveness and intrinsic antibacterial properties was fabricated via a Schiff base linkage and a hydrogen bond.	Hydrogen	191-199	choline phosphotransferase 1	Homo sapiens	68-71
34767553-4	2021	Binding free energy analysis showed that two triplets of nucleotides U6-C15-A29 and G5-G11-C16, contribute the most to the binding of the cognate ligands, by hydrogen bonding and by base stacking, respectively.	Hydrogen	158-166	placenta associated 8	Homo sapiens	72-75
34767553-6	2021	For the synthetic ligands, the hydrogen-bonding contributions of the U6-C15-A29 triplet are significantly compromised, and the bound state resembles the apo state in several respects, including the disengagement of the C15-A14-A13 and A32-G33 base stacks.	Hydrogen	31-39	placenta associated 8	Homo sapiens	72-75
34669416-4	2021	Binding in this congested pocket accommodates four hydrogen bond contacts among ligands and substrates, ultimately favoring a pre-syn arrangement highlighted by pyridinium-azomethine activation and quinolinium-nitronate activation.	Hydrogen	51-59	synemin	Homo sapiens	130-133
34739337-10	2021	The heat-denatured form of Der p1 unexpectedly increased MMP-9 gene expression, which, through the use of in silico models, was attributed to its ability to change receptor connections by the formation of new electrostatic and hydrogen bonds.	Hydrogen	227-235	matrix metallopeptidase 9	Homo sapiens	57-62
34328988-6	2021	Bulky substituents and structural rigidity of the connecting C dramatically impair hydrogen bonding between GPER and the bisphenols, which results in decreased contribution of both favorable intermolecular hydrogen bonds and unfavorable polar solvation effect to complex stability of BPB and BPC since decreased number of key residues is expected.	Hydrogen	83-91	G protein-coupled estrogen receptor 1	Homo sapiens	108-112
34328988-6	2021	Bulky substituents and structural rigidity of the connecting C dramatically impair hydrogen bonding between GPER and the bisphenols, which results in decreased contribution of both favorable intermolecular hydrogen bonds and unfavorable polar solvation effect to complex stability of BPB and BPC since decreased number of key residues is expected.	Hydrogen	206-214	G protein-coupled estrogen receptor 1	Homo sapiens	108-112
34746315-10	2021	Western blotting showed that hydrogen treatment reduced Bax and TNFalpha levels.	Hydrogen	29-37	BCL2-associated X protein	Mus musculus	56-59
34746315-13	2021	Hydrogen treatment also decreased Bax and TNFalpha levels and induced an anti-inflammatory response via regulation of IL-2 and IL-10.	Hydrogen	0-8	BCL2-associated X protein	Mus musculus	34-37
34686998-0	2022	NMR 1H, 13C, 15N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation.	Hydrogen	4-6	KRAS proto-oncogene, GTPase	Homo sapiens	101-107
34686998-5	2022	Due to this dynamic feature of the protein, the 1H-15N correlation cross-peak signals of several amino acid (AA) residues of KRAS belonging to the flexible loop regions are absent from its 2D 1H-15N HSQC spectrum within and near physiological solution pH.	Hydrogen	48-50	KRAS proto-oncogene, GTPase	Homo sapiens	125-129
34686998-5	2022	Due to this dynamic feature of the protein, the 1H-15N correlation cross-peak signals of several amino acid (AA) residues of KRAS belonging to the flexible loop regions are absent from its 2D 1H-15N HSQC spectrum within and near physiological solution pH.	Hydrogen	192-194	KRAS proto-oncogene, GTPase	Homo sapiens	125-129
34523144-3	2021	Here, we used NMR and HDX-MS (Hydrogen deuterium exchange mass spectrometry) in lipid nanodiscs to gain important high-resolution structural insights into the conformational changes of Bak at the membrane that are dependent on a direct activation by BH3-only proteins.	Hydrogen	30-38	BCL2 antagonist/killer 1	Homo sapiens	185-188
34523147-3	2021	To explore the metamorphosis of membrane-bound BAK, we employed hydrogen-deuterium exchange mass spectrometry (HDX-MS).	Hydrogen	64-72	BCL2 antagonist/killer 1	Homo sapiens	47-50
34605656-0	2021	Vibrational Spectra of Atmospherically Relevant Hydrogen-Bonded MSA   (H2SO4)n (n = 1-3) Clusters.	Hydrogen	48-56	thyroid peroxidase	Homo sapiens	64-67
34605656-1	2021	Methanesulfonic acid (CH3SO3H), also known as MSA, has been found to be capable of forming a strong hydrogen-bonded interaction with sulfuric acid (H2SO4) under ambient conditions.	Hydrogen	100-108	thyroid peroxidase	Homo sapiens	46-49
34605656-3	2021	We have performed, in the present work, a detailed and systematic quantum-chemical calculation with high-level density functional theory to characterize the hydrogen bond formation in the binary MSA   H2SO4, ternary MSA   (H2SO4)2, and quaternary MSA   (H2SO4)3 clusters.	Hydrogen	157-165	thyroid peroxidase	Homo sapiens	195-198
34605656-3	2021	We have performed, in the present work, a detailed and systematic quantum-chemical calculation with high-level density functional theory to characterize the hydrogen bond formation in the binary MSA   H2SO4, ternary MSA   (H2SO4)2, and quaternary MSA   (H2SO4)3 clusters.	Hydrogen	157-165	thyroid peroxidase	Homo sapiens	216-219
34605656-3	2021	We have performed, in the present work, a detailed and systematic quantum-chemical calculation with high-level density functional theory to characterize the hydrogen bond formation in the binary MSA   H2SO4, ternary MSA   (H2SO4)2, and quaternary MSA   (H2SO4)3 clusters.	Hydrogen	157-165	thyroid peroxidase	Homo sapiens	247-250
34620279-11	2021	Furthermore, molecular docking showed that osthole interacts with Val468 residues of DCLK1 to form hydrogen bonds.	Hydrogen	99-107	doublecortin like kinase 1	Homo sapiens	85-90
34552165-7	2021	The 2sRK model has an advantage to the solubility theory: Since it can describe the dynamic process, it can be used to discuss both the amount of hydrogen absorption and the absorption rate.	Hydrogen	146-154	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	5-8
34310942-9	2021	As an attempt to characterize the conformational ensemble of CALX-CBD12 in the Apo state, we applied molecular dynamics (MD) simulations, NMR (1H-15N RDCs) and Small-Angle X-Ray Scattering (SAXS) data in a combined strategy to select an ensemble of conformations in agreement with the experimental data.	Hydrogen	143-145	Na/Ca-exchange protein	Drosophila melanogaster	61-65
34468295-12	2022	Literature surveys indicate several structural requirements for inhibitory potency and selectivity towards HDAC-10, e.g., electrostatic and/or hydrogen bond interactions with E274 and complementarity to the P(E,A) CE motif helix.	Hydrogen	143-151	histone deacetylase 10	Homo sapiens	107-114
34246707-7	2021	Molecular docking indicated that CK bound at Sudlow"s site II of serum albumin and formed hydrogen-bonding interactions with three residues.	Hydrogen	90-98	cytidine/uridine monophosphate kinase 1	Homo sapiens	33-35
34549155-3	2021	The substructures (L HL) contain N-H   N hydrogen bridges, stabilizing the arrangement of the ligands in complexes II, III, 1, and 2.	Hydrogen	41-49	carbonic anhydrase 2	Homo sapiens	119-122
34392674-7	2021	The tensile strength of SR/Pa@SiO2@PDA-2 can be up to 0.560 MPa, which is 1.85 times higher than the tensile strength of pure SR/Pa@SiO2 because the interface compatibility between Pa@SiO2 microcapsules and SR is improved through hydrogen bonding between the abundant groups on the PDA surface and the matrix.	Hydrogen	230-238	transcription factor AP-2 beta	Homo sapiens	35-40
34302157-4	2021	It is worth noting that the P-Co3O4@NiCo-LDH-2/NF material presents excellent hydrogen evolution reaction performance in 1 M KOH alkaline solution.	Hydrogen	78-86	neurofascin	Homo sapiens	47-49
34421092-3	2022	Proton magnetic resonance spectroscopy (1H-MRS) is a non-invasive method for assessing neurological abnormalities at the microscopic level and measures in vivo brain metabolites using a clinical MR machine.	Hydrogen	40-42	MROS	Homo sapiens	43-46
34421092-4	2022	In MR examinations of the pediatric brain, 1H-MRS demonstrates its powerful diagnostic capability when MRI is insufficient for diagnostic features.	Hydrogen	43-45	MROS	Homo sapiens	46-49
34421092-5	2022	MRI and 1H-MRS may be complementary tools for diagnosing and monitoring diseases.	Hydrogen	8-10	MROS	Homo sapiens	11-14
34421092-7	2022	An overview of the clinical implementation of 1H-MRS for the assessment of early pediatric developmental brains as well as the diagnosis, prognostification, and disease monitoring of various non-neoplastic brain disorders, including neonatal encephalopathies and neurometabolic/neurodegenerative diseases, was provided herein.	Hydrogen	46-48	MROS	Homo sapiens	49-52
34421092-8	2022	Qualitative and quantitative 1H-MRS is a powerful non-invasive tool for accessing various brain metabolites to confirm age appropriate peaks and detect abnormal peaks or deficient or reduced peaks, which may facilitate the identification of metabolic and neurodegenerative disorders as well as damage associated with hypoxic-ischemic encephalopathy (HIE).	Hydrogen	29-31	MROS	Homo sapiens	32-35
34421092-9	2022	Moreover, 1H-MRS has potential as a biomarker for monitoring therapeutic efficacy in metabolic diseases and neonatal HIE.	Hydrogen	10-12	MROS	Homo sapiens	13-16
34421092-11	2022	Therefore, 1H-MRS needs to be included more frequently in routine clinical MR examinations of pediatric patients with neurological disorders.	Hydrogen	11-13	MROS	Homo sapiens	14-17
34389670-3	2021	Here, benefiting from the effects of one mitochondrial disease-related point mutation in cytochrome b, we identify a dual role of hydrogen bonding (H-bond) to the propionate group of heme b H of cytochrome bc 1, a common component of energy-conserving systems.	Hydrogen	130-138	mitochondrially encoded cytochrome b	Homo sapiens	89-101
34400635-3	2021	Here, using hydrogen deuterium exchange mass spectrometry (HDX-MS), small angle X-ray scattering (SAXS) and molecular dynamics (MD) simulations, combined with analysis of SMAD signaling, we show that the kinase domain of the type I receptor ALK2 and type II receptor BMPR2 form a heterodimeric complex via their C-terminal lobes.	Hydrogen	12-20	activin A receptor type 1	Homo sapiens	241-245
34443450-9	2021	The structural features of KL and MWLs were investigated by Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectrometry (1H, 13C NMR).	Hydrogen	153-155	klotho	Homo sapiens	27-29
34236199-4	2021	The obtained outcomes demonstrated that the dispersibility of the CNF enhanced favorably upon covering the surface of explosive crystals; the interfacial contact ability between CNFs and energetic crystals was also manifested to be increased, which could be ascribed to the interfacial interaction of hydrogen bonds and the electrostatic force of self-assembly.	Hydrogen	301-309	NPHS1 adhesion molecule, nephrin	Homo sapiens	66-69
34266277-8	2021	It is found that in water and methanol, the most abundant conformers of ML are structurally modified relative to the gas phase, where the major form is ML1, in which the syn conformation of the -OH moiety is stabilized by a OH O=C intramolecular hydrogen bond (HB).	Hydrogen	246-254	synemin	Homo sapiens	170-173
33715691-1	2021	The effects of as-deposited iron (Fe) film thickness and the hydrogen (H2) annealing time on the spin-capability of carbon nanotube (CNT) forest have been studied.	Hydrogen	61-69	spindlin 1	Homo sapiens	97-101
33982347-6	2021	Pairwise comparison between hANP32A and hANP32C revealed that Asp149 (D149) and Asp152 (D152) are involved in hydrogen bonding and electrostatic interactions, respectively, which support vPol activity.	Hydrogen	110-118	acidic nuclear phosphoprotein 32 family member A	Homo sapiens	28-35
34136107-5	2021	Both mutant RAS and activated CRAF expression is associated with formation of membrane ruffles to which they colocalize along with actin, sodium-hydrogen exchangers (NHEs) and phosphorylated myosin phosphatase (pMYPT).	Hydrogen	145-153	v-raf-leukemia viral oncogene 1	Mus musculus	30-34
34090694-3	2021	Hydrogen gas inhalation was initiated 10 minutes before the ischemia.	Hydrogen	0-8	gastrin	Rattus norvegicus	9-12
34090694-6	2021	RESULTS: The increase in extracellular glutamate induced by spinal ischemia was significantly suppressed by 3% hydrogen gas inhalation (P < .05).	Hydrogen	111-119	gastrin	Rattus norvegicus	120-123
34090694-8	2021	Conversely, the preadministration of glutamate transporter-1 inhibitor diminished the suppression of spinal ischemia-induced glutamate increase observed during the inhalation of 3% hydrogen gas.	Hydrogen	181-189	gastrin	Rattus norvegicus	190-193
34090694-9	2021	Immunofluorescence indicated the expression of glutamate transporter-1 in the spinal ischemia group was significantly decreased compared with the sham group, which was attenuated by 3% hydrogen gas inhalation (P < .05).	Hydrogen	185-193	gastrin	Rattus norvegicus	194-197
34090694-10	2021	CONCLUSIONS: Our study demonstrated hydrogen gas inhalation exhibits a protective and concentration-dependent effect against spinal ischemic injury, and glutamate transporter-1 has an important role in the protective effects against spinal cord injury.	Hydrogen	36-44	gastrin	Rattus norvegicus	45-48
34168827-9	2021	Additionally, the dynamic insights obtained from the metadynamics simulations and NCI analyses employed in this work, unveiled the presence of syn-directing noncovalent interactions, such as hydrogen bonding, between the alkenoic acid and the halogen source, which rationalized the experimentally observed diastereoselectivities.	Hydrogen	191-199	synemin	Homo sapiens	143-146
34078536-5	2021	The magnitude of the NOE between 1H nuclei varies from +50% when molecular tumbling is fast to -100% when it is slow, the latter case corresponding to the spin diffusion limit.	Hydrogen	33-35	spindlin 1	Homo sapiens	155-159
35325697-1	2022	Hydrogen bond donor functionalized poly(ionic liquids) were incorporated into MIL-101 framework for synthesis of composites PIL-R@MIL-101 (R = COOH, OH, NH2).	Hydrogen	0-8	serpin family A member 2 (gene/pseudogene)	Homo sapiens	124-127
35512552-12	2022	Moreover, LNG and DDG formed the same hydrogen bonds with green-sensitive opsin-4 and rhodopsin kinase GRK7a.	Hydrogen	38-46	opsin 1 (cone pigments), medium-wave-sensitive, 4	Danio rerio	58-81
35428021-8	2022	A 2.46 A structure of N63T iso-1-Cytc identifies a change to a hydrogen bond network linking Omega-loops C and D that could modulate the local fluctuations needed for the intrinsic peroxidase activity of Cytc.	Hydrogen	63-71	eukaryotic translation initiation factor 1	Homo sapiens	27-32
35219194-5	2022	In addition, the production of hydrogen in an electrolytic water device with Co9S8-Ni3S2-CNTs/NF as bifunctional electrode prowered by the electricity derived from solar and wind energy in laboratory condition was artificially simulated.	Hydrogen	31-39	neurofascin	Homo sapiens	94-96
35220189-3	2022	The optimized Ni3S2-FeS/NF-2 electrode realized ultra-high efficiency for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER).	Hydrogen	110-118	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	24-28
35355153-6	2022	The molecular docking study on hCA-I and hCA-II demonstrates that complexes interact via hydrogen bonding as well as different types of pi-stacking.	Hydrogen	89-97	carbonic anhydrase 1	Homo sapiens	31-36
35150953-3	2022	Benefitted from the optimized electronic configuration, hierarchical structure and abundant active sites, the Mo,Fe-NiCoPx/NF electrode has shown competitive oxygen evolution reaction (n10 = 197 mV) and hydrogen evolution reaction performance (n10 = 99 mV) when the current density is 10 mA cm-2 in 1 M KOH solution.	Hydrogen	203-211	neurofascin	Homo sapiens	123-125
35178593-0	2022	Clinical 1H MRS in childhood neurometabolic diseases-part 1: technique and age-related normal spectra.	Hydrogen	9-11	MROS	Homo sapiens	12-15
35178593-1	2022	Despite its vigorous ability to detect and measure metabolic disturbances, 1H MRS remains underutilized in clinical practice.	Hydrogen	75-77	MROS	Homo sapiens	78-81
35224679-0	2022	Clinical 1H MRS in childhood neurometabolic diseases - part 2: MRS signatures.	Hydrogen	9-11	MROS	Homo sapiens	12-15
35224679-3	2022	This review highlights childhood neurometabolic diseases in which 1H MRS may show diagnostic or suggestive metabolic profiles without complicated acquisition or postprocessing techniques.	Hydrogen	66-68	MROS	Homo sapiens	69-72
35549155-1	2022	A compact tandem excitation source-in-source was designed by arranging a point discharge (PD) ignited in argon/hydrogen (Ar/H2) flame and utilized for boosted excitation for the optical emission of chromium.	Hydrogen	111-119	ADP-ribosylhydrolase like 1	Homo sapiens	121-126
35257727-1	2022	Sodium alginate/krill protein/polyacrylamide (SA/AKP/PAM) hydrogel with "covalent bond-ion complex-hydrogen bond" multi-network structure was prepared by covalent cross-linking and complexion ion crosslinking using SA, AKP, and acrylamide (AM) as raw materials.	Hydrogen	99-107	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	53-56
35438111-0	2022	Cyclic voltammetry electrodynamic deposition of Co9-xMnxS8 nanosheet arrays for electrocatalytic hydrogen evolution.	Hydrogen	97-105	phosphoserine phosphatase pseudogene 1	Homo sapiens	48-51
35438111-3	2022	The Co9-xMnxS8 (x = 4.5) catalyst exhibits enhanced catalytic activity toward the hydrogen evolution reaction (HER) when compared with pristine Co9S8.	Hydrogen	82-90	phosphoserine phosphatase pseudogene 1	Homo sapiens	4-7
35394160-5	2022	The results revealed that BPs quenched the endogenous fluorescence of TTR via the combination of static quenching and non-radiative energy transfer, and the van der Waals forces and hydrogen bonding played a synergistic role in the binding process of BPs and TTR.	Hydrogen	182-190	transthyretin	Homo sapiens	70-73
35217022-4	2022	MP12 sequence showed a significant binding score and has multiple hydrogen bond interactions with the proteins that play a vital role in apoptotic pathways such as Bcl-2, caspase-3, caspase-7, and XIAP.	Hydrogen	66-74	X-linked inhibitor of apoptosis	Homo sapiens	197-201
35564808-0	2022	Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes: Evidence from a Pilot Study.	Hydrogen	26-34	ataxin 1 like	Homo sapiens	107-111
35384651-5	2022	Here, we explore by hydrogen-deuterium exchange mass spectrometry the dynamic consequences of a classic substrate and inhibitor, vinblastine and zosuquidar, binding to mouse P-gp (mdr1a) in lipid nanodiscs.	Hydrogen	20-28	phosphoglycolate phosphatase	Mus musculus	174-178
35397701-0	2022	Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.	Hydrogen	101-109	KRAS proto-oncogene, GTPase	Homo sapiens	82-85
35458266-5	2022	A-TCNE, A-TCNQ, and A-F4-TCNQ molecules are characterized comprehensively via UV-Vis-NIR spectra, 1H NMR spectra, infrared spectroscopy, and mass spectrometry.	Hydrogen	98-100	AF4/FMR2 family member 1	Homo sapiens	20-24
35381900-9	2022	The data obtained from hydrogen bond analysis revealed a more equilibrated and stable form of the ClyA-affiEGFR-GALA structure upon interaction with EGFR.	Hydrogen	23-31	galactosidase alpha	Homo sapiens	112-116
35279507-3	2022	Homonuclear dipolar coupling can also impact T2 lifetimes and CPMG echo trains; these effects have been thoroughly investigated for spectra of homonuclear dipolar coupled spin-1/2 nuclei typically acquired under static conditions that are predominantly influenced by dipolar broadening (e.g., 1H, 19F, etc.).	Hydrogen	293-295	spindlin 1	Homo sapiens	171-179
35407938-2	2022	Ru/NF was then tested as a catalyst for a hydrogen evolution reaction.	Hydrogen	42-50	neurofascin	Homo sapiens	3-5
35557761-5	2022	The coexistence of a lone pair electron on the nitrogen atom and a hydrogen-bonding donor (the protonated form of nitrogen and hydroxyl group) affords proximity between hPAG and O2.	Hydrogen	67-75	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Homo sapiens	169-173
35406210-2	2022	The resulting composite film showed good mechanical strength, with a tensile strength reaching 71.84 Mpa due to the high flexibility of CNF and the combination of CS, CNF and BPEI through strong hydrogen bonding interactions.	Hydrogen	195-203	NPHS1 adhesion molecule, nephrin	Homo sapiens	136-139
35406210-2	2022	The resulting composite film showed good mechanical strength, with a tensile strength reaching 71.84 Mpa due to the high flexibility of CNF and the combination of CS, CNF and BPEI through strong hydrogen bonding interactions.	Hydrogen	195-203	NPHS1 adhesion molecule, nephrin	Homo sapiens	167-170
35258916-4	2022	During the mechanical stirring process, the released Ga3+ can cross-link with sodium alginate to form microgels covering the surface of LM droplets, which exhibits shear-thinning performance due to the formation and rupture of hydrogen bonds under different stress conditions, making the LMM ink possess excellent printability and superior adhesion to various substrates.	Hydrogen	227-235	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	53-56
35262139-5	2022	Particularly high incorporation yields and clean 19F-NMR spectra were obtained for GB1 produced with valine residues, which had been synthesized with a single fluorine substituting a hydrogen stereospecifically in one of the methyl groups.	Hydrogen	183-191	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	83-86
35183218-5	2022	Here, using proton magnetic resonance spectroscopy (1H-MRS) at 9.4T, we found significant differences in the levels of different metabolites or their ratios in the prefrontal cortex and hippocampus of Cntnap2-/- mice compared to their wild-type littermates.	Hydrogen	52-54	contactin associated protein-like 2	Mus musculus	201-208
35168606-11	2022	Decreased expressions of GPCPD1 and GDE1 in choline metabolism led to an increased GPC levels in the PTX-resistant EOCs, which was observed as an elevated total choline (tCho) on in vivo 1H-MRS.	Hydrogen	187-189	glycophorin C (Gerbich blood group)	Homo sapiens	83-86
34618887-0	2022	Attenuation of Myocardial Fibrosis Using Molecular Hydrogen by Inhibiting the TGF-beta Signaling Pathway in Spontaneous Hypertensive Rats.	Hydrogen	51-59	transforming growth factor alpha	Rattus norvegicus	78-86
35059399-10	2021	Molecular docking and small-molecule interaction analyses with PTP1B both showed that MIC-1 inhibited PTP1B activity by binding to its active site through hydrogen bonding and hydrophobic interactions.	Hydrogen	155-163	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	63-68
35059399-10	2021	Molecular docking and small-molecule interaction analyses with PTP1B both showed that MIC-1 inhibited PTP1B activity by binding to its active site through hydrogen bonding and hydrophobic interactions.	Hydrogen	155-163	growth differentiation factor 15	Homo sapiens	86-91
35059399-10	2021	Molecular docking and small-molecule interaction analyses with PTP1B both showed that MIC-1 inhibited PTP1B activity by binding to its active site through hydrogen bonding and hydrophobic interactions.	Hydrogen	155-163	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	102-107
35042401-5	2022	Inspection of the AlphaFold human PINK1 structure model predicts a conserved N-terminal alpha-helical extension (NTE) domain forming an intramolecular interaction with the C-terminal extension (CTE), which we corroborate using hydrogen/deuterium exchange mass spectrometry of recombinant insect PINK1 protein.	Hydrogen	227-235	PTEN induced kinase 1	Homo sapiens	34-39