PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34426153-6	2021	Among them, the paratrifluromethyl analog B-2a and the 2, 4-difluoro-5-chloro derivative B-11b showed more potent inhibitory activity against cathepsin L than the control compound, ABR, which displayed the strongest inhibitory effect on cathepsin L and S among all reported asperphenamate derivatives.	asperphenamate	274-288	cathepsin L	Mus musculus	142-153
34426153-6	2021	Among them, the paratrifluromethyl analog B-2a and the 2, 4-difluoro-5-chloro derivative B-11b showed more potent inhibitory activity against cathepsin L than the control compound, ABR, which displayed the strongest inhibitory effect on cathepsin L and S among all reported asperphenamate derivatives.	asperphenamate	274-288	cathepsin L	Mus musculus	237-248
33438557-6	2021	RESULTS: Experimental in vitro testing of highest-ranked hits identified asperphenamate and salvianolic acid B as active SIRT2 inhibitors with IC50 values in low micromolar range.	asperphenamate	73-87	sirtuin 2	Homo sapiens	121-126
30253340-6	2018	The docking results showed the three derivatives interacted more tightly with either cathepsin L or cathepsin S than with asperphenamate.	asperphenamate	122-136	cathepsin L	Homo sapiens	85-96
22668848-0	2012	JNK-dependent Atg4 upregulation mediates asperphenamate derivative BBP-induced autophagy in MCF-7 cells.	asperphenamate	41-55	mitogen-activated protein kinase 8	Homo sapiens	0-3