PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19594761-6	2009	Both 6-shogaol and 6-paradol were found to activate TRPV1 and TRPA1 channels, whereas linalool, an abundant terpene in Sichuan pepper, activated TRPA1 but not TRPV1 channels.	6-paradol	19-28	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	52-57
25789481-6	2015	Pretreatment with 6-paradol reduced neuroinflammatory responses in LPS-stimulated BV2 microglia by a concentration-dependent manner, which includes reduced NO production by inhibiting iNOS upregulation and lowered secretion of proinflammatory cytokines (IL-6 and TNF-alpha).	6-paradol	18-27	nitric oxide synthase 2, inducible	Mus musculus	184-188
25789481-6	2015	Pretreatment with 6-paradol reduced neuroinflammatory responses in LPS-stimulated BV2 microglia by a concentration-dependent manner, which includes reduced NO production by inhibiting iNOS upregulation and lowered secretion of proinflammatory cytokines (IL-6 and TNF-alpha).	6-paradol	18-27	interleukin 6	Mus musculus	254-258
25789481-6	2015	Pretreatment with 6-paradol reduced neuroinflammatory responses in LPS-stimulated BV2 microglia by a concentration-dependent manner, which includes reduced NO production by inhibiting iNOS upregulation and lowered secretion of proinflammatory cytokines (IL-6 and TNF-alpha).	6-paradol	18-27	tumor necrosis factor	Mus musculus	263-272
25789481-9	2015	Furthermore, as observed in cultured microglia, 6-paradol administration markedly reduced neuroinflammation in M/R-challenged brains by attenuating microglial activation and reducing the number of cells expressing iNOS and TNF-alpha, both of which are known to be produced in microglia following M/R challenge.	6-paradol	48-57	nitric oxide synthase 2, inducible	Mus musculus	214-218
25789481-9	2015	Furthermore, as observed in cultured microglia, 6-paradol administration markedly reduced neuroinflammation in M/R-challenged brains by attenuating microglial activation and reducing the number of cells expressing iNOS and TNF-alpha, both of which are known to be produced in microglia following M/R challenge.	6-paradol	48-57	tumor necrosis factor	Mus musculus	223-232
19594761-6	2009	Both 6-shogaol and 6-paradol were found to activate TRPV1 and TRPA1 channels, whereas linalool, an abundant terpene in Sichuan pepper, activated TRPA1 but not TRPV1 channels.	6-paradol	19-28	transient receptor potential cation channel subfamily A member 1	Homo sapiens	62-67
11809529-0	2002	Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells.	6-paradol	67-78	caspase 3	Mus musculus	27-36
11809529-6	2002	These results suggest that [6]-paradol and structurally related derivatives induce apoptosis through a caspase-3-dependent mechanism.	6-paradol	27-38	caspase 3	Mus musculus	103-112
11551496-6	2001	Topical application of [6]-paradol and its derivatives inhibited TPA-induced ear edema and H(2)O(2) production and myeloperoxidase activity in the dorsal skin of mice.	6-paradol	23-34	myeloperoxidase	Mus musculus	115-130
34376189-0	2021	(6)-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling.	6-paradol	0-11	epidermal growth factor receptor	Homo sapiens	87-91
34376189-0	2021	(6)-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling.	6-paradol	0-11	AKT serine/threonine kinase 1	Homo sapiens	114-117
35091105-0	2022	6-Paradol alleviates diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR pathway and NLRP3 inflammasome inhibition.	6-paradol	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	98-102
35091105-0	2022	6-Paradol alleviates diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR pathway and NLRP3 inflammasome inhibition.	6-paradol	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	103-106
35091105-0	2022	6-Paradol alleviates diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR pathway and NLRP3 inflammasome inhibition.	6-paradol	0-9	mechanistic target of rapamycin kinase	Rattus norvegicus	107-111
35091105-0	2022	6-Paradol alleviates diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR pathway and NLRP3 inflammasome inhibition.	6-paradol	0-9	NLR family, pyrin domain containing 3	Rattus norvegicus	124-129
32010796-6	2018	The results from studies of pure 6-paradol and 6-shogaol confirmed that these two compounds could suppress hTERT expression as well as telomerase activity in A549 cells.	6-paradol	33-42	telomerase reverse transcriptase	Homo sapiens	107-112
35040364-7	2022	Paradol-induced cell apoptosis was confirmed by annexin V-FITC/PI staining and nuclear morphology.	6-paradol	0-7	annexin A5	Homo sapiens	48-57
35040364-9	2022	Collectively, our data revealed that paradol inhibited cell viability and migration of GBM cells by inducing G0/G1 phase arrest and apoptosis, and activating ERK and p38 MAPK signaling.	6-paradol	37-44	mitogen-activated protein kinase 1	Homo sapiens	158-161
33441125-15	2021	There were non-significant differences between low and medium doses and between medium and high doses of 6-paradol for IL-6 and serum MDA levels.	6-paradol	105-114	interleukin 6	Rattus norvegicus	119-123
32010796-7	2018	These results suggest that these paradols and shogaols are likely the active compounds in ZOE that suppress hTERT expression and telomerase activity in these cells.	6-paradol	33-41	telomerase reverse transcriptase	Homo sapiens	108-113
28274629-0	2017	Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.	6-paradol	11-20	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	61-76
28274629-3	2017	In this study, the inhibitory effects of 6-paradol on the activities of cytochrome P450 (CYP) enzymes were investigated with human liver microsomes and recombinant CYP isozymes.	6-paradol	41-50	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	72-87
28274629-3	2017	In this study, the inhibitory effects of 6-paradol on the activities of cytochrome P450 (CYP) enzymes were investigated with human liver microsomes and recombinant CYP isozymes.	6-paradol	41-50	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-92
28274629-3	2017	In this study, the inhibitory effects of 6-paradol on the activities of cytochrome P450 (CYP) enzymes were investigated with human liver microsomes and recombinant CYP isozymes.	6-paradol	41-50	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	164-167
28274629-4	2017	6-Paradol showed concentration-dependent inhibitory effects on CYP1A2, CYP2B6, CYP2C8, CYP2C9, and CYP2C19 isozymes, with IC50 values ranging from 3.8 to 21.4microM in recombinant CYP isozymes.	6-paradol	0-9	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	63-69
28274629-4	2017	6-Paradol showed concentration-dependent inhibitory effects on CYP1A2, CYP2B6, CYP2C8, CYP2C9, and CYP2C19 isozymes, with IC50 values ranging from 3.8 to 21.4microM in recombinant CYP isozymes.	6-paradol	0-9	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	71-77
28274629-4	2017	6-Paradol showed concentration-dependent inhibitory effects on CYP1A2, CYP2B6, CYP2C8, CYP2C9, and CYP2C19 isozymes, with IC50 values ranging from 3.8 to 21.4microM in recombinant CYP isozymes.	6-paradol	0-9	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	79-85
28274629-4	2017	6-Paradol showed concentration-dependent inhibitory effects on CYP1A2, CYP2B6, CYP2C8, CYP2C9, and CYP2C19 isozymes, with IC50 values ranging from 3.8 to 21.4microM in recombinant CYP isozymes.	6-paradol	0-9	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	87-93
28274629-4	2017	6-Paradol showed concentration-dependent inhibitory effects on CYP1A2, CYP2B6, CYP2C8, CYP2C9, and CYP2C19 isozymes, with IC50 values ranging from 3.8 to 21.4microM in recombinant CYP isozymes.	6-paradol	0-9	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	99-106
28274629-4	2017	6-Paradol showed concentration-dependent inhibitory effects on CYP1A2, CYP2B6, CYP2C8, CYP2C9, and CYP2C19 isozymes, with IC50 values ranging from 3.8 to 21.4microM in recombinant CYP isozymes.	6-paradol	0-9	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-66