PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2815150-1 1989 C-4 and C-6 bridged haptens of 11 alpha-hydroxyprogesterone, an anti-androgen, were respectively synthesized via 4, 5 and 5 alpha, 6 alpha epoxide ring openings using 3-mercaptopropanoic acid. 11-hydroxyprogesterone 31-59 complement C4A (Rodgers blood group) Homo sapiens 0-11 12435797-6 2002 In contrast, 11 beta-hydroxyprogesterone (11OHP) activated the transiently expressed hMR in COS-7 cells in a dose-dependent manner (ED(50): 10(-8) M) and, like aldosterone, stimulated Ams I(sc) in mpkCCD(cl4) cells. 11-hydroxyprogesterone 13-40 mannose receptor C-type 1 Homo sapiens 85-88 10375032-3 1999 11beta-hydroxyprogesterone binds well to both the glucocorticoid receptor and the carrier protein transcortin. 11-hydroxyprogesterone 0-26 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 50-73 10375032-3 1999 11beta-hydroxyprogesterone binds well to both the glucocorticoid receptor and the carrier protein transcortin. 11-hydroxyprogesterone 0-26 serpin family A member 6 Rattus norvegicus 98-109 9426159-9 1997 The steroid specificity of the binding sites, as determined by competing [3H]corticosterone with unlabeled steroids, is identical to that of 11 beta-HSD2: corticosterone >> 11-hydroxyprogesterone > carbenoxolone > 11 dehydrocorticosterone > cortisol > progesterone approximately DOC >>> DEX > RU 28362 - aldosterone. 11-hydroxyprogesterone 179-201 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 141-153 9029719-10 1997 The reductase activity of 11 beta-HSD1 was inhibited by 11 alpha-hydroxyprogesterone > carbenoxolone = glycyrrhetinic acid = progesterone > 11 beta-hydroxyprogesterone. 11-hydroxyprogesterone 56-84 RNA, U1 small nuclear 1 Homo sapiens 4-38 8641180-9 1996 11 alpha-Hydroxyprogesterone (11 alpha OH-P) was an order of magnitude more potent a competitive inhibitor of the 11 beta HSD-2 than was glycyrrhetinic acid (GA) (approximate IC50 = 0.9 vs. 15 nM). 11-hydroxyprogesterone 0-28 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 114-127 31039398-0 2019 11alpha-Hydroxyprogesterone, a potent 11beta-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5alpha-reductase and cytochrome P450 17alpha-hydroxylase/17,20-lyase to produce C11alpha-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro. 11-hydroxyprogesterone 0-27 endogenous retrovirus group K member 25 Homo sapiens 191-199 3203757-5 1988 Administration of Gesterol 4 to 6 hours before hCG significantly increased the LH values (19.0 +/- 10.3) compared with those who had Gesterol at the time of hCG (6.8 +/- 2.8, P = 0.0006). 11-hydroxyprogesterone 18-26 hypertrichosis 2 (generalised, congenital) Homo sapiens 47-50 3546944-8 1987 Consequently high levels of plasma 21-deoxycorticosterone were found in treated patients suffering from congenital adrenal hyperplasia (CAH) with 21-hydroxylase deficiency, particularly in CAH salt-losers with high plasma renin activity (PRA), where the plasma level reached 40,545 pmol/l. 11-hydroxyprogesterone 35-57 renin Homo sapiens 222-227 32247282-9 2021 The C11-oxy C21 steroids, 11-hydroxyprogesterone and 11keto-dihydroprogesterone levels, were 1.2- and 1.7-fold higher in PCOS patients compared to HVs, respectively. 11-hydroxyprogesterone 26-48 aldo-keto reductase family 1 member C4 Homo sapiens 4-15 32007561-0 2020 CYP17A1 exhibits 17alpha-hydroxylase/17,20-lyase activity towards 11beta-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway. 11-hydroxyprogesterone 66-92 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 32007561-0 2020 CYP17A1 exhibits 17alpha-hydroxylase/17,20-lyase activity towards 11beta-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway. 11-hydroxyprogesterone 66-92 aldo-keto reductase family 1 member C4 Homo sapiens 136-139 31090904-7 2019 The GR was activated with comparable potency to cortisol by corticosterone and 21-deoxycortisol or with 4-100x lower potency by 11-hydroxyprogesterone, 11-deoxycortisol, aldosterone, 11-deoxycorticosterone, progesterone, and 17-hydroxyprogesterone. 11-hydroxyprogesterone 128-150 nuclear receptor subfamily 3 group C member 1 Homo sapiens 4-6 31039398-1 2019 11alpha-Hydroxyprogesterone (11alphaOHP4) and 11beta-hydroxyprogesterone (11betaOHP4) have been reported to be inhibitors of 11beta-hydroxysteroid dehydrogenase (11betaHSD) type 2, together with 11beta-hydroxytestosterone and 11beta-hydroxyandrostenedione, and their C11-keto derivatives being inhibitors of 11betaHSD1. 11-hydroxyprogesterone 0-27 aldo-keto reductase family 1 member C4 Homo sapiens 267-270 30825506-4 2019 The apparent Km and Vmax values indicate the more prominent 11betaHSD2 activity towards 11beta-hydroxy androstenedione, 11beta-hydroxytestosterone and 11beta-hydroxyprogesterone in contrast to the 11betaHSD1 reduction of the C11-keto steroids, as was demonstrated in the LNCaP cell model in the production of 11-ketotestosterone and 11-ketodihydrotestosterone. 11-hydroxyprogesterone 151-177 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 60-70 24176792-4 2014 3alpha,5alpha-Tetrahydro-corticosterone, 11beta-hydroxy-progesterone, and 3alpha,5alpha-tetrahydro-11beta-hydroxy-progesterone strongly inhibit 11beta-HSD2 and 11beta-HSD1 dehydrogenase activity; all these compounds are hypertensinogenic when infused in adrenally intact rats. 11-hydroxyprogesterone 41-68 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 144-155 24074876-1 2013 11beta-Hydroxyprogesterone is a well-known nonselective inhibitor of 11beta-hydroxysteroid dehydrogenase (11betaHSD) types 1 and 2. 11-hydroxyprogesterone 0-26 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 69-130 17223084-3 2007 A UGT2B7-15-7 chimera that incorporated amino acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein, but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone. 11-hydroxyprogesterone 187-214 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 2-8 17223084-3 2007 A UGT2B7-15-7 chimera that incorporated amino acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein, but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone. 11-hydroxyprogesterone 187-214 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 62-69 17223084-3 2007 A UGT2B7-15-7 chimera that incorporated amino acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein, but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone. 11-hydroxyprogesterone 187-214 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 89-96