PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9029719-10	1997	The reductase activity of 11 beta-HSD1 was inhibited by 11 alpha-hydroxyprogesterone > carbenoxolone = glycyrrhetinic acid = progesterone > 11 beta-hydroxyprogesterone.	11-hydroxyprogesterone	56-84	RNA, U1 small nuclear 1	Homo sapiens	4-38
24176792-4	2014	3alpha,5alpha-Tetrahydro-corticosterone, 11beta-hydroxy-progesterone, and 3alpha,5alpha-tetrahydro-11beta-hydroxy-progesterone strongly inhibit 11beta-HSD2 and 11beta-HSD1 dehydrogenase activity; all these compounds are hypertensinogenic when infused in adrenally intact rats.	11-hydroxyprogesterone	41-68	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	144-155
17223084-3	2007	A UGT2B7-15-7 chimera that incorporated amino acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein, but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone.	11-hydroxyprogesterone	187-214	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	2-8
17223084-3	2007	A UGT2B7-15-7 chimera that incorporated amino acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein, but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone.	11-hydroxyprogesterone	187-214	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	62-69
17223084-3	2007	A UGT2B7-15-7 chimera that incorporated amino acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein, but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone.	11-hydroxyprogesterone	187-214	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	89-96
12435797-6	2002	In contrast, 11 beta-hydroxyprogesterone (11OHP) activated the transiently expressed hMR in COS-7 cells in a dose-dependent manner (ED(50): 10(-8) M) and, like aldosterone, stimulated Ams I(sc) in mpkCCD(cl4) cells.	11-hydroxyprogesterone	13-40	mannose receptor C-type 1	Homo sapiens	85-88
10375032-3	1999	11beta-hydroxyprogesterone binds well to both the glucocorticoid receptor and the carrier protein transcortin.	11-hydroxyprogesterone	0-26	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	50-73
10375032-3	1999	11beta-hydroxyprogesterone binds well to both the glucocorticoid receptor and the carrier protein transcortin.	11-hydroxyprogesterone	0-26	serpin family A member 6	Rattus norvegicus	98-109
9426159-9	1997	The steroid specificity of the binding sites, as determined by competing [3H]corticosterone with unlabeled steroids, is identical to that of 11 beta-HSD2: corticosterone >> 11-hydroxyprogesterone > carbenoxolone > 11 dehydrocorticosterone > cortisol > progesterone approximately DOC >>> DEX > RU 28362 - aldosterone.	11-hydroxyprogesterone	179-201	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	141-153
24074876-1	2013	11beta-Hydroxyprogesterone is a well-known nonselective inhibitor of 11beta-hydroxysteroid dehydrogenase (11betaHSD) types 1 and 2.	11-hydroxyprogesterone	0-26	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	69-130
8641180-9	1996	11 alpha-Hydroxyprogesterone (11 alpha OH-P) was an order of magnitude more potent a competitive inhibitor of the 11 beta HSD-2 than was glycyrrhetinic acid (GA) (approximate IC50 = 0.9 vs. 15 nM).	11-hydroxyprogesterone	0-28	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	114-127
3203757-5	1988	Administration of Gesterol 4 to 6 hours before hCG significantly increased the LH values (19.0 +/- 10.3) compared with those who had Gesterol at the time of hCG (6.8 +/- 2.8, P = 0.0006).	11-hydroxyprogesterone	18-26	hypertrichosis 2 (generalised, congenital)	Homo sapiens	47-50
32007561-0	2020	CYP17A1 exhibits 17alpha-hydroxylase/17,20-lyase activity towards 11beta-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway.	11-hydroxyprogesterone	66-92	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	0-7
32007561-0	2020	CYP17A1 exhibits 17alpha-hydroxylase/17,20-lyase activity towards 11beta-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway.	11-hydroxyprogesterone	66-92	aldo-keto reductase family 1 member C4	Homo sapiens	136-139
31090904-7	2019	The GR was activated with comparable potency to cortisol by corticosterone and 21-deoxycortisol or with 4-100x lower potency by 11-hydroxyprogesterone, 11-deoxycortisol, aldosterone, 11-deoxycorticosterone, progesterone, and 17-hydroxyprogesterone.	11-hydroxyprogesterone	128-150	nuclear receptor subfamily 3 group C member 1	Homo sapiens	4-6
31039398-0	2019	11alpha-Hydroxyprogesterone, a potent 11beta-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5alpha-reductase and cytochrome P450 17alpha-hydroxylase/17,20-lyase to produce C11alpha-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro.	11-hydroxyprogesterone	0-27	endogenous retrovirus group K member 25	Homo sapiens	191-199
31039398-1	2019	11alpha-Hydroxyprogesterone (11alphaOHP4) and 11beta-hydroxyprogesterone (11betaOHP4) have been reported to be inhibitors of 11beta-hydroxysteroid dehydrogenase (11betaHSD) type 2, together with 11beta-hydroxytestosterone and 11beta-hydroxyandrostenedione, and their C11-keto derivatives being inhibitors of 11betaHSD1.	11-hydroxyprogesterone	0-27	aldo-keto reductase family 1 member C4	Homo sapiens	267-270
2815150-1	1989	C-4 and C-6 bridged haptens of 11 alpha-hydroxyprogesterone, an anti-androgen, were respectively synthesized via 4, 5 and 5 alpha, 6 alpha epoxide ring openings using 3-mercaptopropanoic acid.	11-hydroxyprogesterone	31-59	complement C4A (Rodgers blood group)	Homo sapiens	0-11
3546944-8	1987	Consequently high levels of plasma 21-deoxycorticosterone were found in treated patients suffering from congenital adrenal hyperplasia (CAH) with 21-hydroxylase deficiency, particularly in CAH salt-losers with high plasma renin activity (PRA), where the plasma level reached 40,545 pmol/l.	11-hydroxyprogesterone	35-57	renin	Homo sapiens	222-227
32247282-9	2021	The C11-oxy C21 steroids, 11-hydroxyprogesterone and 11keto-dihydroprogesterone levels, were 1.2- and 1.7-fold higher in PCOS patients compared to HVs, respectively.	11-hydroxyprogesterone	26-48	aldo-keto reductase family 1 member C4	Homo sapiens	4-15
30825506-4	2019	The apparent Km and Vmax values indicate the more prominent 11betaHSD2 activity towards 11beta-hydroxy androstenedione, 11beta-hydroxytestosterone and 11beta-hydroxyprogesterone in contrast to the 11betaHSD1 reduction of the C11-keto steroids, as was demonstrated in the LNCaP cell model in the production of 11-ketotestosterone and 11-ketodihydrotestosterone.	11-hydroxyprogesterone	151-177	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	60-70