PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7046992-3	1982	Severe and persistent metabolic acidosis and hyperglycemia, despite large doses of insulin, were observed in this infant, who excreted large amounts of methylmalonic acid.	Methylmalonic Acid	152-170	insulin	Homo sapiens	83-90
2795894-0	1989	[Urinary methylmalonic acid excretion and clinical features in megaloblastic anemia due to vitamin B12 deficiency].	Methylmalonic Acid	9-27	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	99-102
2795894-1	1989	Urinary methylmalonic acid (MMA) excretion in megaloblastic anemia due to vitamin B12 (B12) deficiency was studied using a colorimetric method.	Methylmalonic Acid	8-26	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	82-85
2795894-1	1989	Urinary methylmalonic acid (MMA) excretion in megaloblastic anemia due to vitamin B12 (B12) deficiency was studied using a colorimetric method.	Methylmalonic Acid	8-26	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	87-90
2795894-1	1989	Urinary methylmalonic acid (MMA) excretion in megaloblastic anemia due to vitamin B12 (B12) deficiency was studied using a colorimetric method.	Methylmalonic Acid	28-31	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	82-85
2795894-1	1989	Urinary methylmalonic acid (MMA) excretion in megaloblastic anemia due to vitamin B12 (B12) deficiency was studied using a colorimetric method.	Methylmalonic Acid	28-31	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	87-90
2795894-2	1989	Average MMA excretion in 20 patients with untreated B12 deficiency was 164 mg/day, whereas it increased to 518 mg/day following oral administration of 10 g L-valine.	Methylmalonic Acid	8-11	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	52-55
3611958-0	1987	New urinary methylmalonic acid test is a sensitive indicator of cobalamin (vitamin B12) deficiency: a solution for a major unrecognized medical problem.	Methylmalonic Acid	12-30	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	83-86
4074667-7	1985	The photoinhibition of BDH in the presence of N3-NAD was prevented nearly completely by addition of NADH, NAD plus beta-hydroxybutyrate, or NAD plus 2-methylmalonate and partially by addition of NAD.	Methylmalonic Acid	149-165	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	23-26
656065-2	1978	The disturbance in 2-methylmalonate metabolism resulting in its increased urinary excretion observed in vitamin E deficiency is not caused by increased formation of methylmalonate from propionate as is evident from the activity of the enzyme propionyl-CoA carboxylase (EC 6.4.1.3), but can be traced to an impairment in the conversion of methylmalonate into succinate by the vitamin B12-requiring enzyme, methylmalonyl-CoA mutase (EC 5.4.99.2) in rat liver.	Methylmalonic Acid	19-35	methylmalonyl-CoA mutase	Rattus norvegicus	405-429
6101617-2	1980	In addition, deficient animals excreted some 15 times as much methylmalonic acid as controls indicating impaired functioning of the vitamin B-12-dependent enzyme, methylmalonyl CoA mutase (EC 5.4.99.2).	Methylmalonic Acid	62-80	methylmalonyl-CoA mutase	Rattus norvegicus	163-187
31740360-2	2020	High serum levels of methylmalonic acid (MMA) have been identified in several studies as an early indicator of vitamin B12 deficiency.	Methylmalonic Acid	21-39	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	119-122
239344-3	1975	Treatment during the last nine weeks of gestation with large doses of vitamin B12 given to the mother reversed the increasing maternal excretion of methylmalonic acid, which was 23 mug per milligram of creatinine at 31 weeks" gestation.	Methylmalonic Acid	148-166	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	78-81
32754920-10	2021	Methylmalonic acid (MMA) levels in urine and plasma were significantly lower in cblA.	Methylmalonic Acid	0-18	metabolism of cobalamin associated A	Homo sapiens	80-84
32754920-10	2021	Methylmalonic acid (MMA) levels in urine and plasma were significantly lower in cblA.	Methylmalonic Acid	20-23	metabolism of cobalamin associated A	Homo sapiens	80-84
34046142-5	2021	Urinary concentrations of methylmalonic acid and homocysteine are characteristically elevated in vitamin B12 deficiency.	Methylmalonic Acid	26-44	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	105-108
33515116-2	2021	Variants in the MMACHC gene cause accumulation of methylmalonic acid and homocysteine along with decreased methionine synthesis.	Methylmalonic Acid	50-68	metabolism of cobalamin associated C	Homo sapiens	16-22
32470975-9	2020	On multiple variable regression analysis after adjusting for treatment group, intrauterine growth restriction, and home environment, P300 amplitude in children was significantly higher in the lowest tertile of third-trimester maternal methylmalonic acid (MMA) concentrations (beta = 3034.04; 95% CI: 923.24, 5144.83) compared with the highest MMA tertile (beta = 1612.12; 95% CI: -258.86, 3483.10, P = 0.005).	Methylmalonic Acid	235-253	E1A binding protein p300	Homo sapiens	133-137
31740360-2	2020	High serum levels of methylmalonic acid (MMA) have been identified in several studies as an early indicator of vitamin B12 deficiency.	Methylmalonic Acid	41-44	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	119-122
31740360-15	2020	Correlation analysis revealed significantly negative correlation between MMA and B12 levels only in patients without comorbidities.	Methylmalonic Acid	73-76	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	81-84
31740360-16	2020	CONCLUSION: HF patients have elevated MMA levels, independently of age, gender, HF category or comorbidities, possibly indicating subclinical vitamin-B12 deficiency.	Methylmalonic Acid	38-41	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	150-153
31805132-7	2019	RESULTS: Treatment with a PPARalpha agonist was associated with increased plasma concentrations of most biomarkers, with the most pronounced differences observed for betaine, dimethylglycine, glycine, nicotinamide, methylnicotinamide, pyridoxal and methylmalonic acid.	Methylmalonic Acid	249-267	peroxisome proliferator activated receptor alpha	Rattus norvegicus	26-35
31473512-8	2019	Women with genetic variants in choline dehydrogenase (CHDH) and betaine-homocysteine S-methyltransferase (BHMT) had higher serum MMA concentrations (~31%, P=.03) and lower serum holotranscobalamin concentrations (~34%, P=.03), respectively.	Methylmalonic Acid	129-132	choline dehydrogenase	Homo sapiens	31-52
31471907-10	2019	CONCLUSION: Taken together, these findings suggest that participants with lower vitamin B12 and higher MMA levels that considered as lower functional activity of B12 had higher odds of migraine.	Methylmalonic Acid	103-106	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	162-165
31473512-8	2019	Women with genetic variants in choline dehydrogenase (CHDH) and betaine-homocysteine S-methyltransferase (BHMT) had higher serum MMA concentrations (~31%, P=.03) and lower serum holotranscobalamin concentrations (~34%, P=.03), respectively.	Methylmalonic Acid	129-132	choline dehydrogenase	Homo sapiens	54-58
31473512-8	2019	Women with genetic variants in choline dehydrogenase (CHDH) and betaine-homocysteine S-methyltransferase (BHMT) had higher serum MMA concentrations (~31%, P=.03) and lower serum holotranscobalamin concentrations (~34%, P=.03), respectively.	Methylmalonic Acid	129-132	betaine--homocysteine S-methyltransferase	Homo sapiens	64-104
31473512-8	2019	Women with genetic variants in choline dehydrogenase (CHDH) and betaine-homocysteine S-methyltransferase (BHMT) had higher serum MMA concentrations (~31%, P=.03) and lower serum holotranscobalamin concentrations (~34%, P=.03), respectively.	Methylmalonic Acid	129-132	betaine--homocysteine S-methyltransferase	Homo sapiens	106-110
29845181-6	2018	In vivo, the developed vitamin B12 loaded nanoparticle showed increased serum vitamin B12 levels upon oral administration and reduced the methylmalonic acid level more efficiently than the free form in rats.	Methylmalonic Acid	138-156	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	31-34
29620684-4	2019	His plasma total homocysteine and urinary methylmalonic acid levels were elevated, and a homozygous nonsense mutation [p. R250X (c.748C>T] leading to premature termination of translation was identified in the MMADHC gene, which was compatible with CblD defect.	Methylmalonic Acid	42-60	metabolism of cobalamin associated D	Homo sapiens	212-218
29874929-2	2018	However, impaired clearance of MMA from blood due to decreased glomerular filtration rate (eGFR) also results in elevated plasma MMA concentrations.	Methylmalonic Acid	31-34	epidermal growth factor receptor	Homo sapiens	91-95
29874929-2	2018	However, impaired clearance of MMA from blood due to decreased glomerular filtration rate (eGFR) also results in elevated plasma MMA concentrations.	Methylmalonic Acid	129-132	epidermal growth factor receptor	Homo sapiens	91-95
31146325-0	2019	MCEE Mutations in an Adult Patient with Parkinson"s Disease, Dementia, Stroke and Elevated Levels of Methylmalonic Acid.	Methylmalonic Acid	101-119	methylmalonyl-CoA epimerase	Homo sapiens	0-4
31193945-5	2019	In this review, we describe the heterogeneous disease spectrum of patients with vitamin B12 deficiency in whom the diagnosis was either based on low serum B12 levels, elevated biomarkers like methylmalonic acid and/or homocysteine, or the improvement of clinical symptoms after the institution of parenteral vitamin B12 therapy.	Methylmalonic Acid	192-210	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	88-91
33636915-1	2018	BACKGROUND: Increased methylmalonic acid (MMA) levels can aid in assessing vitamin B12 deficiency or abnormal propionate metabolism.	Methylmalonic Acid	22-40	activation induced cytidine deaminase	Homo sapiens	58-61
33636915-1	2018	BACKGROUND: Increased methylmalonic acid (MMA) levels can aid in assessing vitamin B12 deficiency or abnormal propionate metabolism.	Methylmalonic Acid	42-45	activation induced cytidine deaminase	Homo sapiens	58-61
30214334-3	2018	The serum level of vitamin B12 was mildly decreased with high methylmalonic acid and homocysteine levels.	Methylmalonic Acid	62-80	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	27-30
29172662-3	2017	Biochemically, vitamin B12 deficiency leads to an accumulation of methylmalonic acid, homocysteine, and propionylcarnitine.	Methylmalonic Acid	66-84	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	23-26
29262333-5	2017	administration of hMUT mRNA in two different mouse models of MMA resulted in a 75%-85% reduction in plasma methylmalonic acid and was associated with increased hMUT protein expression and activity in liver.	Methylmalonic Acid	107-125	methylmalonyl-CoA mutase	Homo sapiens	18-22
29153845-6	2017	Thirty-seven mutant ABC transporters were screened for the excretion of methylmalonic acid (MMA), which should result from loss of Cbl transport into the mitochondria.	Methylmalonic Acid	72-90	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	20-23
29153845-6	2017	Thirty-seven mutant ABC transporters were screened for the excretion of methylmalonic acid (MMA), which should result from loss of Cbl transport into the mitochondria.	Methylmalonic Acid	72-90	Cbl proto-oncogene	Homo sapiens	131-134
29153845-6	2017	Thirty-seven mutant ABC transporters were screened for the excretion of methylmalonic acid (MMA), which should result from loss of Cbl transport into the mitochondria.	Methylmalonic Acid	92-95	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	20-23
29153845-6	2017	Thirty-seven mutant ABC transporters were screened for the excretion of methylmalonic acid (MMA), which should result from loss of Cbl transport into the mitochondria.	Methylmalonic Acid	92-95	Cbl proto-oncogene	Homo sapiens	131-134
29172662-10	2017	We also detected an additional vitamin B12-deficient infant with neurological symptoms at 4 months of age, after a normal newborn screening, because of elevated urinary methylmalonic acid concentration.	Methylmalonic Acid	169-187	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	39-42
29172662-13	2017	Conslusions: Optimizing the cut off values of current screening parameters and measuring of methylmalonic acid and/or homocysteine in the dried blood spot, as a second tier test, can improve recognition rate of vitamin B12 deficiency.	Methylmalonic Acid	92-110	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	219-222
28537576-5	2017	Methylmalonic acid and homocysteine normalised following B12 injections.	Methylmalonic Acid	0-18	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	57-60
28925645-5	2017	Measurement of serum methylmalonic acid should be used to confirm deficiency in asymptomatic high-risk patients with low-normal levels of vitamin B12.	Methylmalonic Acid	21-39	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	146-149
28166085-7	2017	Our case demonstrates the importance of the methyl malonic acid test to detect early or mild vitamin B12 deficiency as a cause of myelopathy while serum vitamin B12 level may be normal.	Methylmalonic Acid	44-63	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	101-104
28660890-8	2017	Diagnostic biomarkers for B12 status include decreased levels of circulating total B12 and transcobalamin-bound B12, and abnormally increased levels of homocysteine and methylmalonic acid.	Methylmalonic Acid	169-187	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	26-29
28566165-11	2017	In the majority of the cases PN has been linked to abnormalities in vitamin B12, methylmalonic acid or fasting homocysteine levels.	Methylmalonic Acid	81-99	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	29-31
28363510-0	2017	X-Linked Cobalamin Disorder (HCFC1) Mimicking Nonketotic Hyperglycinemia With Increased Both Cerebrospinal Fluid Glycine and Methylmalonic Acid.	Methylmalonic Acid	125-143	host cell factor C1	Homo sapiens	29-34
28363510-11	2017	CONCLUSIONS: This boy had X-linked cobalamin deficiency (HCFC1) with increased cerebrospinal fluid glycine and methylmalonic acid and increased cerebrospinal fluid to plasma glycine ratio suggesting a brain hyperglycinemia.	Methylmalonic Acid	111-129	host cell factor C1	Homo sapiens	57-62
28333089-2	2017	Methylmalonic acid (MMA) is a sensitive indicator of B12 status.	Methylmalonic Acid	0-18	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	53-56
28333089-2	2017	Methylmalonic acid (MMA) is a sensitive indicator of B12 status.	Methylmalonic Acid	20-23	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	53-56
27858373-6	2017	MMA level remained always in the normal range.To date, placement of a subcutaneous catheter to minimize the pain related to parenteral vitamin B12 punctures has been described only in a patient with deficiency of the enzyme methylmalonyl-CoA mutase (MUT).	Methylmalonic Acid	0-3	methylmalonyl-CoA mutase	Homo sapiens	224-248
28395089-5	2017	MMA-injected mice showed increased levels of the reactive oxygen species marker 2",7"-dichlorofluorescein diacetate, tumor necrosis factor, interleukin-1beta, caspases 1, 3, and 8, and increased acetylcholinesterase activity in the cortex, hippocampus and striatum.	Methylmalonic Acid	0-3	interleukin 1 beta	Mus musculus	140-179
29188889-1	2017	BACKGROUND: Vitamin B12 status is measured by four plasma/ serum biomarkers: total vitamin B12 (total B12), holotranscobalamin (holoTC), methylmalonic acid (MMA) and homocysteine (tHcy).	Methylmalonic Acid	157-160	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	20-23
29188889-9	2017	RESULTS: A doubling of B12 intake was associated with 9% higher total B12, 15% higher HoloTC, 9% lower MMA and 2% lower tHcy.	Methylmalonic Acid	103-106	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	23-26
29188889-11	2017	Spline regression showed that levels of MMA and tHcy started to rise when vitamin B12 levels fall below 330 pmol/L and with HoloTC levels below 100 pmol/L, with a sharp increase with levels of B12 and HoloTC below 220 and 50 pmol/L respectively.	Methylmalonic Acid	40-43	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	82-85
29188889-11	2017	Spline regression showed that levels of MMA and tHcy started to rise when vitamin B12 levels fall below 330 pmol/L and with HoloTC levels below 100 pmol/L, with a sharp increase with levels of B12 and HoloTC below 220 and 50 pmol/L respectively.	Methylmalonic Acid	40-43	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	193-196
27349184-2	2016	Inborn errors of Cbl metabolism are rare Mendelian disorders associated with hematological and neurological manifestations, and elevations of methylmalonic acid and/or homocysteine in the blood and urine.	Methylmalonic Acid	142-160	Cbl proto-oncogene	Homo sapiens	17-20
27446930-2	2016	Deficiency of Cbl, whether nutritional or due to inborn errors of Cbl metabolism, inactivate MS and MCM leading to the accumulation of homocysteine (Hcy) and methylmalonic acid (MMA), respectively.	Methylmalonic Acid	158-176	Cbl proto-oncogene	Homo sapiens	14-17
27492701-2	2016	AMR lead to increased methylmalonic acid in plasma and urine without hyperhomocysteinemia.	Methylmalonic Acid	22-40	G protein-coupled receptor 182	Homo sapiens	0-3
27003903-2	2016	Functional vitamin B12 deficiency, defined by elevated levels of the B12-dependent metabolites, methylmalonic acid (MMA), and/or homocysteine, despite normal B12 values, may cause neuropathy and is associated with disorders linked to increased oxidative stress.	Methylmalonic Acid	96-114	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	19-22
27446930-2	2016	Deficiency of Cbl, whether nutritional or due to inborn errors of Cbl metabolism, inactivate MS and MCM leading to the accumulation of homocysteine (Hcy) and methylmalonic acid (MMA), respectively.	Methylmalonic Acid	178-181	Cbl proto-oncogene	Homo sapiens	14-17
26983191-6	2014	Direct metabolic consequences of impaired B12 absorption and metabolism are the accumulation of methylmalonic acid (MMA) and of homocysteine (HCy), respectively.	Methylmalonic Acid	96-114	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	42-45
26825869-10	2016	Homocysteine and methylmalonic acid levels decreased significantly after FA/B12 administration, and remained below baseline levels during the study.	Methylmalonic Acid	17-35	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	76-79
26992463-6	2016	Receiver operating characteristic analysis of NeS-DW ability to detect MMA 367 nmol/L revealed a significant area under the curve AUC = 0.761 P   0.001 95% CI 0.693-0.830.	Methylmalonic Acid	71-74	nestin	Homo sapiens	46-49
27132595-0	2016	A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin.	Methylmalonic Acid	42-60	3-hydroxyisobutyryl-CoA hydrolase	Homo sapiens	25-30
27132595-1	2016	Methylmalonic acid (MMA) is a by-product of propionic acid metabolism through the vitamin B12 (cobalamin)-dependent enzyme methylmalonyl CoA mutase.	Methylmalonic Acid	0-18	methylmalonyl-CoA mutase	Homo sapiens	123-147
27132595-1	2016	Methylmalonic acid (MMA) is a by-product of propionic acid metabolism through the vitamin B12 (cobalamin)-dependent enzyme methylmalonyl CoA mutase.	Methylmalonic Acid	20-23	methylmalonyl-CoA mutase	Homo sapiens	123-147
27132595-8	2016	The association between MMA levels and HIBCH rs291466 was highly significant in a replication cohort of 1,481 older individuals (median age 79 years) with elevated plasma MMA concentrations (0.34 [0.24-0.51] mumol/L; p = 4.0 x 10(-26)).	Methylmalonic Acid	24-27	3-hydroxyisobutyryl-CoA hydrolase	Homo sapiens	39-44
27132595-8	2016	The association between MMA levels and HIBCH rs291466 was highly significant in a replication cohort of 1,481 older individuals (median age 79 years) with elevated plasma MMA concentrations (0.34 [0.24-0.51] mumol/L; p = 4.0 x 10(-26)).	Methylmalonic Acid	171-174	3-hydroxyisobutyryl-CoA hydrolase	Homo sapiens	39-44
26296064-3	2015	Holotranscobalamin (holoTC) combined with methylmalonic acid (MMA) is believed to be more accurate in identifying impaired B12 status.	Methylmalonic Acid	62-65	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	123-126
26226119-1	2015	PURPOSE: The objective of the study was to determine the incidence of vitamin B12 deficiency in patients under long-term treatment for phenylketonuria (PKU) and hyperphenylalaninemia (HPA), as well as its associations with B12 vitamin parameters (holotranscobalamin - active vitamin B12, serum folate, total plasma homocysteine, and plasma methylmalonic acid concentration).	Methylmalonic Acid	340-358	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	78-81
25756278-5	2015	Setting a cut-off level to define serum vitamin B12 deficiency is difficult; though homocysteine and methylmalonic acid are more sensitive for vitamin B12 deficiency, it may give false result in some conditions and the reference intervals are not standardised.	Methylmalonic Acid	101-119	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	151-154
25467488-1	2015	Methylmalonic acid (MMA) and total homocysteine (tHCYS) concentrations are used to detect acquired and inborn errors of cobalamin (vitamin B12, Cbl) metabolism and to evaluate the effect of therapeutic interventions.	Methylmalonic Acid	0-18	Cbl proto-oncogene	Homo sapiens	144-147
25205257-1	2014	Methylmalonic and propionic acidemia (MMA/PA) are inborn errors of metabolism characterized by accumulation of propionic acid and/or methylmalonic acid due to deficiency of methylmalonyl-CoA mutase (MUT) or propionyl-CoA carboxylase (PCC).	Methylmalonic Acid	133-151	monocyte to macrophage differentiation associated	Homo sapiens	0-44
25205257-1	2014	Methylmalonic and propionic acidemia (MMA/PA) are inborn errors of metabolism characterized by accumulation of propionic acid and/or methylmalonic acid due to deficiency of methylmalonyl-CoA mutase (MUT) or propionyl-CoA carboxylase (PCC).	Methylmalonic Acid	133-151	methylmalonyl-CoA mutase	Homo sapiens	173-197
24722857-1	2014	In humans vitamin B12 (cobalamin, Cbl) must be converted into two coenzyme forms, methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), in order to maintain intracellular homeostasis of homocysteine and methylmalonic acid, respectively.	Methylmalonic Acid	205-223	Cbl proto-oncogene	Homo sapiens	34-37
26915364-1	2016	BACKGROUND: The presence of increased urinary concentrations of both methylmalonic acid (MMA) and malonic acid (MA) is assumed to differentiate combined malonic and methylmalonic aciduria (CMAMMA), due to mutations in the ACSF3 gene, from other causes of methylmalonic aciduria (classic MMAemia).	Methylmalonic Acid	69-87	acyl-CoA synthetase family member 3	Homo sapiens	222-227
26915364-1	2016	BACKGROUND: The presence of increased urinary concentrations of both methylmalonic acid (MMA) and malonic acid (MA) is assumed to differentiate combined malonic and methylmalonic aciduria (CMAMMA), due to mutations in the ACSF3 gene, from other causes of methylmalonic aciduria (classic MMAemia).	Methylmalonic Acid	89-92	acyl-CoA synthetase family member 3	Homo sapiens	222-227
25762406-9	2015	The cblC defect can be screened by measuring propionylcarnitine, propionylcarnitine-to-acetylcarnitine ratio combined with the second tier markers methylmalonic acid and tHcy.	Methylmalonic Acid	147-165	Cbl proto-oncogene C	Homo sapiens	4-8
26248135-4	2015	Using L2 yolk sac cells, megalin localized to the submembrane compartment by methylmalonic acid (MMA), which accumulates during vitamin B12 deficiency.	Methylmalonic Acid	77-95	LDL receptor related protein 2	Rattus norvegicus	25-32
26248135-4	2015	Using L2 yolk sac cells, megalin localized to the submembrane compartment by methylmalonic acid (MMA), which accumulates during vitamin B12 deficiency.	Methylmalonic Acid	97-100	LDL receptor related protein 2	Rattus norvegicus	25-32
26248135-5	2015	In addition, MMA inhibited megalin-mediated endocytosis via YWTD repeats motif in an ectodomain of megalin.	Methylmalonic Acid	13-16	LDL receptor related protein 2	Rattus norvegicus	27-34
26248135-5	2015	In addition, MMA inhibited megalin-mediated endocytosis via YWTD repeats motif in an ectodomain of megalin.	Methylmalonic Acid	13-16	LDL receptor related protein 2	Rattus norvegicus	99-106
26983191-6	2014	Direct metabolic consequences of impaired B12 absorption and metabolism are the accumulation of methylmalonic acid (MMA) and of homocysteine (HCy), respectively.	Methylmalonic Acid	116-119	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	42-45
24225845-6	2013	Functional measures and reported disabilities were associated with B12 deficiency definitions that include B12 biomarkers (homocysteine or methylmalonic acid).	Methylmalonic Acid	139-157	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	67-70
24719898-0	2014	Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes.	Methylmalonic Acid	8-26	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	60-63
24719898-3	2014	We want to determine the levels of urinary methylmalonic acid and its relationships with serum vitamin B12 and polyneuropathy.	Methylmalonic Acid	43-61	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	103-106
24719898-10	2014	Urinary methylmalonic acid correlates with serum vitamin B12 levels in person with diabetes and is a sensitive marker of early polyneuropathy.	Methylmalonic Acid	8-26	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	57-60
24330302-1	2013	Deficiency in methylmalonyl-coenzyme A mutase (MCM) is associated with accumulation of methylmalonic acid (MMA) and clinical outcomes that include early death and neurological impairment.	Methylmalonic Acid	87-105	methylmalonyl-CoA mutase	Homo sapiens	14-45
24330302-1	2013	Deficiency in methylmalonyl-coenzyme A mutase (MCM) is associated with accumulation of methylmalonic acid (MMA) and clinical outcomes that include early death and neurological impairment.	Methylmalonic Acid	87-105	methylmalonyl-CoA mutase	Homo sapiens	47-50
24330302-1	2013	Deficiency in methylmalonyl-coenzyme A mutase (MCM) is associated with accumulation of methylmalonic acid (MMA) and clinical outcomes that include early death and neurological impairment.	Methylmalonic Acid	107-110	methylmalonyl-CoA mutase	Homo sapiens	14-45
24330302-1	2013	Deficiency in methylmalonyl-coenzyme A mutase (MCM) is associated with accumulation of methylmalonic acid (MMA) and clinical outcomes that include early death and neurological impairment.	Methylmalonic Acid	107-110	methylmalonyl-CoA mutase	Homo sapiens	47-50
23726524-7	2013	The blood of MMA-treated animals showed a decrease in the number of polymorphonuclear and neutrophils, and an increase in mononuclear and other cell types, as well as an increase of IL-1beta and TNF-alpha levels.	Methylmalonic Acid	13-16	interleukin 1 beta	Rattus norvegicus	182-190
23726524-7	2013	The blood of MMA-treated animals showed a decrease in the number of polymorphonuclear and neutrophils, and an increase in mononuclear and other cell types, as well as an increase of IL-1beta and TNF-alpha levels.	Methylmalonic Acid	13-16	tumor necrosis factor	Rattus norvegicus	195-204
21232119-12	2011	One month of vitamin B12 treatment (N = 26) lowered serum MMA levels by 0.13 mumol/l (95%CI 0.06-0.19) more than the change observed in the placebo group (N = 23).	Methylmalonic Acid	58-61	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	21-24
23475280-8	2013	In rats receiving gentamicin simultaneously with MMA, it was observed an increase in the activity of acetylcholinesterase activity in cerebral cortex, without any alteration in the activity of the other studied enzymes.	Methylmalonic Acid	49-52	acetylcholinesterase	Rattus norvegicus	101-121
25369926-5	2013	A useful process for assessing vitamin B12 status in clinical practice is the combination of taking a diet history, testing serum vitamin B12 level and testing homocysteine, holotranscobalamin II or methylmalonic acid serum levels.	Methylmalonic Acid	199-217	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	39-42
23453891-6	2013	The PN may be linked to use of high-dose levodopa, promoting high levels of homocysteine and methylmalonic acid or reduced absorption of vitamins essential for homocysteine metabolism.	Methylmalonic Acid	93-111	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	4-6
23421317-3	2013	AIM: Investigate the association between Dihydrofolate reductase (DHFR) 19-base pair (bp) deletion and Serine hydroxymethyltransferase (SHMT) C1420T polymorphisms and serum folate and plasma Hcy and methylmalonic acid (MMA) concentrations in 85 individuals with DS.	Methylmalonic Acid	199-217	dihydrofolate reductase	Homo sapiens	41-64
23421317-3	2013	AIM: Investigate the association between Dihydrofolate reductase (DHFR) 19-base pair (bp) deletion and Serine hydroxymethyltransferase (SHMT) C1420T polymorphisms and serum folate and plasma Hcy and methylmalonic acid (MMA) concentrations in 85 individuals with DS.	Methylmalonic Acid	199-217	dihydrofolate reductase	Homo sapiens	66-70
23421317-3	2013	AIM: Investigate the association between Dihydrofolate reductase (DHFR) 19-base pair (bp) deletion and Serine hydroxymethyltransferase (SHMT) C1420T polymorphisms and serum folate and plasma Hcy and methylmalonic acid (MMA) concentrations in 85 individuals with DS.	Methylmalonic Acid	199-217	serine hydroxymethyltransferase 1	Homo sapiens	136-140
23421317-3	2013	AIM: Investigate the association between Dihydrofolate reductase (DHFR) 19-base pair (bp) deletion and Serine hydroxymethyltransferase (SHMT) C1420T polymorphisms and serum folate and plasma Hcy and methylmalonic acid (MMA) concentrations in 85 individuals with DS.	Methylmalonic Acid	219-222	dihydrofolate reductase	Homo sapiens	41-64
23421317-3	2013	AIM: Investigate the association between Dihydrofolate reductase (DHFR) 19-base pair (bp) deletion and Serine hydroxymethyltransferase (SHMT) C1420T polymorphisms and serum folate and plasma Hcy and methylmalonic acid (MMA) concentrations in 85 individuals with DS.	Methylmalonic Acid	219-222	dihydrofolate reductase	Homo sapiens	66-70
23421317-3	2013	AIM: Investigate the association between Dihydrofolate reductase (DHFR) 19-base pair (bp) deletion and Serine hydroxymethyltransferase (SHMT) C1420T polymorphisms and serum folate and plasma Hcy and methylmalonic acid (MMA) concentrations in 85 individuals with DS.	Methylmalonic Acid	219-222	serine hydroxymethyltransferase 1	Homo sapiens	136-140
23421317-6	2013	RESULTS: Individuals with DHFR DD/SHMT TT genotypes presented increased folate concentrations (p=0.004) and the DHFR II/SHMT TT genotypes were associated with increased MMA concentrations (p=0.008).	Methylmalonic Acid	169-172	dihydrofolate reductase	Homo sapiens	112-116
23421317-6	2013	RESULTS: Individuals with DHFR DD/SHMT TT genotypes presented increased folate concentrations (p=0.004) and the DHFR II/SHMT TT genotypes were associated with increased MMA concentrations (p=0.008).	Methylmalonic Acid	169-172	serine hydroxymethyltransferase 1	Homo sapiens	120-124
24083040-6	2013	Further investigation revealed serum vitamin B12 of <30 pg/mL with elevated methylmalonic acid and homocysteine level.	Methylmalonic Acid	79-97	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	45-48
21687976-4	2012	In this study, we analyzed the influence of the polymorphism C1420T in Serine hydroxymethyltransferase (SHMT) gene on maternal risk for DS and on metabolites concentrations of the folate pathway (serum folate and plasma homocysteine and methylmalonic acid).	Methylmalonic Acid	237-255	serine hydroxymethyltransferase 1	Homo sapiens	71-102
21687976-4	2012	In this study, we analyzed the influence of the polymorphism C1420T in Serine hydroxymethyltransferase (SHMT) gene on maternal risk for DS and on metabolites concentrations of the folate pathway (serum folate and plasma homocysteine and methylmalonic acid).	Methylmalonic Acid	237-255	serine hydroxymethyltransferase 1	Homo sapiens	104-108
21153419-2	2011	Cbl-C defect causes the accumulation of methylmalonic acid and homocysteine and decreased methionine synthesis.	Methylmalonic Acid	40-58	Cbl proto-oncogene C	Homo sapiens	0-5
21497144-1	2011	Methylmalonic acid (MMA) is a metabolic intermediate transformed to succinic acid (SA) by a vitamin B(12)-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.	Methylmalonic Acid	0-18	monocyte to macrophage differentiation associated	Homo sapiens	20-23
21426888-0	2011	Parenteral vitamin B12 in macrocytic hemodialysis patients reduced MMA levels but did not change mean red cell volume or hemoglobin.	Methylmalonic Acid	67-70	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	19-22
21426888-14	2011	CONCLUSIONS: IV vitamin B12 led to a sustained decline in MMA levels in macrocytic patients, suggesting functional vitamin B12 deficiency at baseline.	Methylmalonic Acid	58-61	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	24-27
21156318-9	2011	The associations of homocysteine, vitamin B12 and methylmalonic acid with ApoA-I and HDL2a particles and that of homocysteine with increased small size HDL3c suggested mechanisms related with impaired synthesis of ApoA-I and HDL and abnormal maturation of HDL particles.	Methylmalonic Acid	50-68	apolipoprotein A1	Homo sapiens	74-80
21156318-9	2011	The associations of homocysteine, vitamin B12 and methylmalonic acid with ApoA-I and HDL2a particles and that of homocysteine with increased small size HDL3c suggested mechanisms related with impaired synthesis of ApoA-I and HDL and abnormal maturation of HDL particles.	Methylmalonic Acid	50-68	junctophilin 3	Homo sapiens	85-89
20632110-2	2011	Cbl-C defect causes the accumulation of methylmalonic acid and homocysteine and decreased methionine synthesis.	Methylmalonic Acid	40-58	Cbl proto-oncogene C	Homo sapiens	0-5
23356638-3	2013	Using a PubMed search to identify relevant publications, 18 articles were found that reported B12 deficiency rates from studies that identified deficiency by measuring methylmalonic acid, holo-transcobalamin II, or both.	Methylmalonic Acid	168-186	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	94-97
21802231-7	2012	DISCUSSION: MMA is an autosomal recessive disorder caused by a deficiency of methylmalonyl-CoA mutase resulting in methylmalonic acid accumulation.	Methylmalonic Acid	115-133	methylmalonyl-CoA mutase	Homo sapiens	77-101
22377700-5	2012	The polymorphisms MTHFR c.677C>T and solute carrier family 19 (folate transporter), member 1 (SLC19A1) c.80 A>G modulate folate concentrations, whereas the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) c.66A>G polymorphism affects the MMA concentration.	Methylmalonic Acid	271-274	methylenetetrahydrofolate reductase	Homo sapiens	18-23
22377700-5	2012	The polymorphisms MTHFR c.677C>T and solute carrier family 19 (folate transporter), member 1 (SLC19A1) c.80 A>G modulate folate concentrations, whereas the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) c.66A>G polymorphism affects the MMA concentration.	Methylmalonic Acid	271-274	solute carrier family 19 member 1	Homo sapiens	97-104
21497120-4	2011	In the present study we show that cultured skin fibroblasts from cblC patients export increased levels of both homocysteine and methylmalonic acid compared to control skin fibroblasts, and that they also have decreased levels of total intracellular folates.	Methylmalonic Acid	128-146	Cbl proto-oncogene C	Homo sapiens	65-69
21765920-10	2011	Prior to correction for multiple testing, we detected significant associations between TCblR rs9426 and methylmalonic acid (p  =  0.045), total homocysteine levels (tHcy) (p  =  0.033), serum B12 (p < 0.0001), holo transcobalamin (p < 0.0001) and total transcobalamin (p < 0.0001); and between MTHFR rs1537514 and red blood cell folate (p < 0.0001).	Methylmalonic Acid	104-122	CD320 molecule	Homo sapiens	87-92
20549361-5	2010	She had elevated urine malonic and methylmalonic acids and was presumably homozygous for a deleterious mutation in the MLYCD gene.	Methylmalonic Acid	35-54	malonyl-CoA decarboxylase	Homo sapiens	119-124
19073247-5	2009	Visual analysis of electroencephalographic recordings (EEG) showed that MMA injection induced the appearance of high-voltage synchronic spike activity in the ipsilateral cortex which spreads to the contralateral cortex while quantitative electroencephalographic analysis showed larger wave amplitude during MMA-induced seizures in wild-type mice when compared with iNOS knockout mice.	Methylmalonic Acid	72-75	nitric oxide synthase 2, inducible	Mus musculus	365-369
20696242-6	2010	The differences observed regarding the apoptosis rate and preferred pathway between cblB and cblC patients, who both built up methylmalonic acid, might be explained by the accumulated homocysteine in the cblC group.	Methylmalonic Acid	126-144	Cbl proto-oncogene B	Homo sapiens	84-88
20696242-6	2010	The differences observed regarding the apoptosis rate and preferred pathway between cblB and cblC patients, who both built up methylmalonic acid, might be explained by the accumulated homocysteine in the cblC group.	Methylmalonic Acid	126-144	Cbl proto-oncogene C	Homo sapiens	93-97
20696242-6	2010	The differences observed regarding the apoptosis rate and preferred pathway between cblB and cblC patients, who both built up methylmalonic acid, might be explained by the accumulated homocysteine in the cblC group.	Methylmalonic Acid	126-144	Cbl proto-oncogene C	Homo sapiens	204-208
20077088-1	2010	The measurement of plasma or serum methylmalonic acid (MMA) is useful for monitoring therapy in patients with methylmalonic acidemia due to methylmalonyl-CoA mutase deficiency, defects of vitamin B12 metabolism, and also for the determination of functional vitamin B12 deficiency.	Methylmalonic Acid	35-53	methylmalonyl-CoA mutase	Homo sapiens	140-164
20077088-1	2010	The measurement of plasma or serum methylmalonic acid (MMA) is useful for monitoring therapy in patients with methylmalonic acidemia due to methylmalonyl-CoA mutase deficiency, defects of vitamin B12 metabolism, and also for the determination of functional vitamin B12 deficiency.	Methylmalonic Acid	55-58	methylmalonyl-CoA mutase	Homo sapiens	140-164
21120433-2	2010	This study evaluated the influence of a 19-base pair (bp) deletion polymorphism in intron-1 of the dihydrofolate reductase (DHFR) gene on the maternal risk of DS, and investigated the association between this polymorphism and variations in the concentrations of serum folate and plasma homocysteine (Hcy) and plasma methylmalonic acid (MMA).	Methylmalonic Acid	316-334	dihydrofolate reductase	Homo sapiens	124-128
21120433-2	2010	This study evaluated the influence of a 19-base pair (bp) deletion polymorphism in intron-1 of the dihydrofolate reductase (DHFR) gene on the maternal risk of DS, and investigated the association between this polymorphism and variations in the concentrations of serum folate and plasma homocysteine (Hcy) and plasma methylmalonic acid (MMA).	Methylmalonic Acid	336-339	dihydrofolate reductase	Homo sapiens	124-128
19073247-6	2009	We also report that administration of MMA increases NOx (NO(2) plus NO(3) content) and 3-nitrotyrosine (3-NT) levels in a greater extend in iNOS(+/+) mice than in iNOS(-/-) mice, indicating that NO overproduction and NO-mediated damage to proteins are attenuated in iNOS knockout mice.	Methylmalonic Acid	38-41	nitric oxide synthase 2, inducible	Mus musculus	140-144
19073247-6	2009	We also report that administration of MMA increases NOx (NO(2) plus NO(3) content) and 3-nitrotyrosine (3-NT) levels in a greater extend in iNOS(+/+) mice than in iNOS(-/-) mice, indicating that NO overproduction and NO-mediated damage to proteins are attenuated in iNOS knockout mice.	Methylmalonic Acid	38-41	nitric oxide synthase 2, inducible	Mus musculus	163-167
19073247-6	2009	We also report that administration of MMA increases NOx (NO(2) plus NO(3) content) and 3-nitrotyrosine (3-NT) levels in a greater extend in iNOS(+/+) mice than in iNOS(-/-) mice, indicating that NO overproduction and NO-mediated damage to proteins are attenuated in iNOS knockout mice.	Methylmalonic Acid	38-41	nitric oxide synthase 2, inducible	Mus musculus	163-167
19151237-2	2009	Failure of intracellular transport of B12 by transcobalamin-2 can lead to functional B12 deficiency but with apparently normal serum levels, and is suggested by raised levels of either serum methylmalonic acid or homocysteine, associated with low levels of transcobalamin-2.	Methylmalonic Acid	191-209	transcobalamin 2	Homo sapiens	45-61
19277894-1	2009	An adult patient with methylmalonic aciduria due to defective cobalamin synthesis (CblA) responsive to vitamin B(12) presented suddenly with severe visual impairment ascribed to optic atrophy followed by a fatal multiorgan failure and lactic acidosis but low methylmalonic acid in plasma and urine.	Methylmalonic Acid	22-40	metabolism of cobalamin associated A	Homo sapiens	62-81
19277894-1	2009	An adult patient with methylmalonic aciduria due to defective cobalamin synthesis (CblA) responsive to vitamin B(12) presented suddenly with severe visual impairment ascribed to optic atrophy followed by a fatal multiorgan failure and lactic acidosis but low methylmalonic acid in plasma and urine.	Methylmalonic Acid	22-40	metabolism of cobalamin associated A	Homo sapiens	83-87
19151237-2	2009	Failure of intracellular transport of B12 by transcobalamin-2 can lead to functional B12 deficiency but with apparently normal serum levels, and is suggested by raised levels of either serum methylmalonic acid or homocysteine, associated with low levels of transcobalamin-2.	Methylmalonic Acid	191-209	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	38-41
18636794-9	2008	A highly significant correlation between homocysteine and methylmalonic acid and vitamin B12 was observed only in patients but not in controls (p<0.001 and p=0.002, respectively).	Methylmalonic Acid	58-76	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	89-92
18785232-8	2008	Cbl therapy led to improvements in Hcy and MMA levels in all groups, and PN in PD-IPN patients stabilized during therapy.	Methylmalonic Acid	43-46	Cbl proto-oncogene	Homo sapiens	0-3
17823972-2	2007	Two patients who excrete methylmalonic acid have recently been shown to have a homozygous nonsense mutation in the gene coding for methylmalonyl CoA epimerase (MCEE).	Methylmalonic Acid	25-43	methylmalonyl-CoA epimerase	Homo sapiens	131-158
17912246-1	2007	The purpose of this study was to investigate the utility of plasma pharmacokinetic and pharmacodynamic measures including plasma deoxynucleosides, homocysteine and methylmalonic acid concentrations in understanding the time course and extent of the inhibition of thymidylate synthase (TS) by pemetrexed in the context of a phase I/II combination study with vinorelbine.	Methylmalonic Acid	164-182	thymidylate synthetase	Homo sapiens	263-283
17937813-5	2007	To gain insight into the origin and magnitude of methylmalonic acid (MMA) production in humans with methylmalonyl-CoA mutase deficiency, we evaluated two methylmalonic acidemia patients who had received different variants of combined liver-kidney transplants, one with a complete liver replacement-kidney transplant and the other with an auxiliary liver graft-kidney transplant, and compared their metabolite production to four untransplanted patients with intact renal function.	Methylmalonic Acid	49-67	methylmalonyl-CoA mutase	Homo sapiens	100-124
17937813-5	2007	To gain insight into the origin and magnitude of methylmalonic acid (MMA) production in humans with methylmalonyl-CoA mutase deficiency, we evaluated two methylmalonic acidemia patients who had received different variants of combined liver-kidney transplants, one with a complete liver replacement-kidney transplant and the other with an auxiliary liver graft-kidney transplant, and compared their metabolite production to four untransplanted patients with intact renal function.	Methylmalonic Acid	69-72	methylmalonyl-CoA mutase	Homo sapiens	100-124
17823972-2	2007	Two patients who excrete methylmalonic acid have recently been shown to have a homozygous nonsense mutation in the gene coding for methylmalonyl CoA epimerase (MCEE).	Methylmalonic Acid	25-43	methylmalonyl-CoA epimerase	Homo sapiens	160-164
17823972-3	2007	To further understand the cause of methylmalonic acid excretion, the MCEE gene was sequenced in 229 patients with elevations of methylmalonic acid excretion for which no cause was known.	Methylmalonic Acid	35-53	methylmalonyl-CoA epimerase	Homo sapiens	69-73
17823972-3	2007	To further understand the cause of methylmalonic acid excretion, the MCEE gene was sequenced in 229 patients with elevations of methylmalonic acid excretion for which no cause was known.	Methylmalonic Acid	128-146	methylmalonyl-CoA epimerase	Homo sapiens	69-73
17412572-4	2007	Vitamin B12 levels were very low associated with increased methylmalonic acid and homocysteine serum levels which confirm the diagnostic .	Methylmalonic Acid	59-77	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
17597648-6	2007	Chronic renal failure (CRF) was found most frequently in mut0 (61%) and cblB patients (66%), and was predicted by the urinary excretion of methylmalonic acid (MMA) before CRF.	Methylmalonic Acid	139-157	Cbl proto-oncogene B	Homo sapiens	72-76
16464760-1	2005	Vitamin B12 deficiency causes decreased Methionine Synthase and L-Methylmalonyl-CoA Mutase activity and results in accumulation of Homocysteine, Methylmalonic acid and Propionylcarnitine.	Methylmalonic Acid	145-163	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
17287286-0	2007	Mitochondrial encephalomyopathy with elevated methylmalonic acid is caused by SUCLA2 mutations.	Methylmalonic Acid	46-64	succinate-CoA ligase ADP-forming subunit beta	Homo sapiens	78-84
17222169-0	2007	Glomerular filtration rate as measured by serum cystatin C is an important determinant of plasma homocysteine and serum methylmalonic acid in the elderly.	Methylmalonic Acid	120-138	cystatin C	Homo sapiens	48-58
17222169-8	2007	Cystatin C was correlated with tHcy (r = 0.45, P < 0.001) and with MMA (r =0.28, P < 0.001), independently of vitamin B(12)- and folate status.	Methylmalonic Acid	70-73	cystatin C	Homo sapiens	0-10
17222169-11	2007	Nomograms for evaluation of tHcy and MMA in relation to both cystatin C and serum creatinine are presented.	Methylmalonic Acid	37-40	cystatin C	Homo sapiens	61-71
16843692-4	2006	RNA interference against mmcm-1, mmab-1, mmaa-1 in the presence of propionic acid revealed a chemical phenotype of increased methylmalonic acid; deletion mutants of mmcm-1, mmab-1 and mce-1 displayed reduced 1-[(14)C]-propionate incorporation into macromolecules.	Methylmalonic Acid	125-143	putative methylmalonyl-CoA mutase, mitochondrial	Caenorhabditis elegans	25-31
16843692-4	2006	RNA interference against mmcm-1, mmab-1, mmaa-1 in the presence of propionic acid revealed a chemical phenotype of increased methylmalonic acid; deletion mutants of mmcm-1, mmab-1 and mce-1 displayed reduced 1-[(14)C]-propionate incorporation into macromolecules.	Methylmalonic Acid	125-143	Corrinoid adenosyltransferase	Caenorhabditis elegans	33-39
16843692-4	2006	RNA interference against mmcm-1, mmab-1, mmaa-1 in the presence of propionic acid revealed a chemical phenotype of increased methylmalonic acid; deletion mutants of mmcm-1, mmab-1 and mce-1 displayed reduced 1-[(14)C]-propionate incorporation into macromolecules.	Methylmalonic Acid	125-143	Methylmalonic aciduria type A homolog, mitochondrial	Caenorhabditis elegans	41-47
16384886-8	2006	Individuals with low concentrations of both total vitamin B12 and holoTC had significantly higher concentrations of methylmalonic acid and homocysteine than did individuals with total vitamin B12 and/or holoTC within the reference intervals (P < 0.001).	Methylmalonic Acid	116-134	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	58-61
17301081-5	2007	Since the reaction catalysed by succinyl-CoA synthase in the tricarboxylic acid (TCA) cycle represents a distal step of the methylmalonic acid pathway, we investigated the SUCLA2 gene as a candidate gene in our patients.	Methylmalonic Acid	124-142	succinate-CoA ligase ADP-forming subunit beta	Homo sapiens	172-178
17301081-8	2007	Defects in SUCLA2 can be found at the metabolite level and are defined by mildly elevated methylmalonic acid and C4-dicarboxylic carnitine concentrations in body fluids in association with variable lactic acidosis.	Methylmalonic Acid	90-108	succinate-CoA ligase ADP-forming subunit beta	Homo sapiens	11-17
17024475-10	2006	Moreover, we demonstrate a possible interaction between the MTRR 66GG genotype and high plasma MMA levels (OR 5.5, 95% CI 2.2-13.5).	Methylmalonic Acid	95-98	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	60-64
16469366-2	2006	It has been reported that methylmalonic acid (MMA) accumulation inhibits succinate dehydrogenase (SDH) and beta-hydroxybutyrate dehydrogenase activity and respiratory chain complexes in vitro, leading to decreased CO2 production, O2 consumption and increased lactate production.	Methylmalonic Acid	26-44	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	73-96
16469366-2	2006	It has been reported that methylmalonic acid (MMA) accumulation inhibits succinate dehydrogenase (SDH) and beta-hydroxybutyrate dehydrogenase activity and respiratory chain complexes in vitro, leading to decreased CO2 production, O2 consumption and increased lactate production.	Methylmalonic Acid	26-44	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	98-101
16469366-2	2006	It has been reported that methylmalonic acid (MMA) accumulation inhibits succinate dehydrogenase (SDH) and beta-hydroxybutyrate dehydrogenase activity and respiratory chain complexes in vitro, leading to decreased CO2 production, O2 consumption and increased lactate production.	Methylmalonic Acid	46-49	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	73-96
16469366-2	2006	It has been reported that methylmalonic acid (MMA) accumulation inhibits succinate dehydrogenase (SDH) and beta-hydroxybutyrate dehydrogenase activity and respiratory chain complexes in vitro, leading to decreased CO2 production, O2 consumption and increased lactate production.	Methylmalonic Acid	46-49	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	98-101
16385831-3	2005	Insufficient availability of vitamin B12 will lead to the accumulation of methylmalonic acid and homocysteine in the body.	Methylmalonic Acid	74-92	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	37-40
16385831-4	2005	Nearly all patients with vitamin B12 deficiency also have substantially increased levels of methylmalonic acid and homocysteine.	Methylmalonic Acid	92-110	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	33-36
16385831-5	2005	New tests of serum methylmalonic acid and homocysteine are highly sensitive for vitamin B12 deficiency and may obviate the need for the somewhat cumbersome Schilling test.	Methylmalonic Acid	19-37	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	88-91
16464760-6	2005	Homocysteine and Methylmalonic acid may be better markers of Vitamin B12 deficiency.	Methylmalonic Acid	17-35	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	69-72
15898756-1	2005	This communication reports highly enantioselective and diastereoselective methyl malonic acid half thioester (MeMAHT) aldol reactions that are compatible with protic functional groups and enolizable aldehydes, affording syn S-phenyl thiopropionates.	Methylmalonic Acid	74-93	synemin	Homo sapiens	220-223
15926134-3	2005	Both of them had an increased rate of excretion of methylmalonic acid, as well as homocysteine, in urine with extremely low serum levels of vitamin B12, as compared to normal values.	Methylmalonic Acid	51-69	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	148-151
14568819-1	2003	BACKGROUND: Combined methylmalonic aciduria and homocystinuria cobalamin C type (cobalamin C disease) is an inborn metabolic disorder consisting of an impaired intracellular synthesis of the 2 active forms of vitamin B12 (cobalamin), namely, adenosylcobalamin and methylcobalamin, that results in increased levels of methylmalonic acid and homocysteine in the blood and urine.	Methylmalonic Acid	21-39	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	217-220
16197297-6	2005	Elevated concentrations of methylmalonic acid (MMA) is common in infants (age <6 months), which may indicate a transient inadequate vitamin B12 status.	Methylmalonic Acid	27-45	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	143-146
16197297-6	2005	Elevated concentrations of methylmalonic acid (MMA) is common in infants (age <6 months), which may indicate a transient inadequate vitamin B12 status.	Methylmalonic Acid	47-50	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	143-146
15055362-2	2004	Growth hormone (GH) therapy has been considered in the management of these disorders as a mode to enhance anabolism and lower the high levels of methylmalonic acid.	Methylmalonic Acid	145-163	growth hormone 1	Homo sapiens	0-14
15055362-2	2004	Growth hormone (GH) therapy has been considered in the management of these disorders as a mode to enhance anabolism and lower the high levels of methylmalonic acid.	Methylmalonic Acid	145-163	growth hormone 1	Homo sapiens	16-18
15055362-5	2004	In anticipation of using GH therapy to reduce high methylmalonic acid concentrations, the first patient underwent GH testing utilizing a provocative glucagon stimulation test and was found to be deficient.	Methylmalonic Acid	51-69	growth hormone 1	Homo sapiens	25-27
15189123-4	2004	Elevated methylmalonic acid and/or total homocysteine are sensitive indicators of vitamin B12-deficient diets and correlate with clinical abnormalities.	Methylmalonic Acid	9-27	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	90-93
11553056-0	2001	Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy.	Methylmalonic Acid	17-35	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	72-75
12895456-3	2003	In the present study we investigated the effects of ammonium ions on the convulsant action of MMA, MMA-induced inhibition of striatal succinate dehydrogenase, and the striatal content of thiobarbituric acid-reactive substances (TBARS).	Methylmalonic Acid	99-102	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	134-157
12499993-8	2003	However, there was a significant positive correlation between serum MMA and gastrin concentrations.	Methylmalonic Acid	68-71	gastrin	Homo sapiens	76-83
11979347-12	2002	Vitamin B12 supplementation for 8 weeks significantly reduced MMA concentrations in HD patients with normal serum vitamin B12 concentrations.	Methylmalonic Acid	62-65	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
11592449-1	2001	In a pilot study we measured the effect of three different combinations of the vitamins B6, folate and B12 on the serum concentrations of homocysteine, cystathionine and methylmalonic acid in five healthy young men without hyperhomocysteinemia.	Methylmalonic Acid	170-188	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	103-106
12515324-0	2002	Effect of propionic and methylmalonic acids on the high molecular weight neurofilament subunit (NF-H) in rat cerebral cortex.	Methylmalonic Acid	24-43	neurofilament heavy chain	Rattus norvegicus	96-100
11592431-10	2001	Elderly people have a high frequency of vitamin B12 deficiency which can be diagnosed more reliably by the measurement of serum methylmalonic acid (MMA) level than by serum vitamin B12.	Methylmalonic Acid	128-146	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	48-51
11592431-10	2001	Elderly people have a high frequency of vitamin B12 deficiency which can be diagnosed more reliably by the measurement of serum methylmalonic acid (MMA) level than by serum vitamin B12.	Methylmalonic Acid	148-151	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	48-51
11592431-11	2001	Subjects following a strict vegetarian diet also have a high prevalence of hyperhomocysteinemia caused by functional vitamin B12 deficiency (increased MMA level).	Methylmalonic Acid	151-154	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	125-128
11553056-3	2001	Increased methylmalonic acid levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate deficiency.	Methylmalonic Acid	10-28	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	78-81
11553056-6	2001	In addition, a significant inverse correlation was found between methylmalonic acid and vitamin B12.	Methylmalonic Acid	65-83	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	96-99
8929440-0	1996	Methylmalonyl-CoA mutase induction by cerebral ischemia and neurotoxicity of the mitochondrial toxin methylmalonic acid.	Methylmalonic Acid	101-119	methylmalonyl-CoA mutase	Homo sapiens	0-24
9296563-2	1997	We demonstrated that pre-treatment of cerebral cortex slices of young rats with 2.5 mM buffered methylmalonic acid (MMA) is effective in decreasing in vitro incorporation of [32P]ATP into neurofilament subunits (NF-M and NF-L) and alpha- and beta-tubulins.	Methylmalonic Acid	116-119	neurofilament medium chain	Rattus norvegicus	212-216
9296563-2	1997	We demonstrated that pre-treatment of cerebral cortex slices of young rats with 2.5 mM buffered methylmalonic acid (MMA) is effective in decreasing in vitro incorporation of [32P]ATP into neurofilament subunits (NF-M and NF-L) and alpha- and beta-tubulins.	Methylmalonic Acid	116-119	neurofilament light chain	Rattus norvegicus	221-225
9296563-7	1997	Taken together, these results suggest that MMA, at the same concentrations found in tissues of methylmalonic acidemic children, inhibits the in vitro activities of PKA, CaMKII and PP1 associated with the cytoskeletal fraction of the cerebral cortex of rats, a fact that may be involved with the pathogenesis of the neurological dysfunction characteristic of methylmalonic acidemia.	Methylmalonic Acid	43-46	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	169-175
9296563-7	1997	Taken together, these results suggest that MMA, at the same concentrations found in tissues of methylmalonic acidemic children, inhibits the in vitro activities of PKA, CaMKII and PP1 associated with the cytoskeletal fraction of the cerebral cortex of rats, a fact that may be involved with the pathogenesis of the neurological dysfunction characteristic of methylmalonic acidemia.	Methylmalonic Acid	43-46	inorganic pyrophosphatase 1	Homo sapiens	180-183
8929440-7	1996	Methylmalonic acid, which is formed from the MCM substrate methylmalonyl-CoA and which inhibits succinate dehydrogenase (SDH), produced dose-related cell death when injected into the basal ganglia of adult rat brain.	Methylmalonic Acid	0-18	methylmalonyl-CoA mutase	Homo sapiens	45-48
8929440-7	1996	Methylmalonic acid, which is formed from the MCM substrate methylmalonyl-CoA and which inhibits succinate dehydrogenase (SDH), produced dose-related cell death when injected into the basal ganglia of adult rat brain.	Methylmalonic Acid	0-18	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	121-124
8929440-9	1996	Methylmalonic acid may contribute to neuronal injury in human conditions in which it accumulates, including MCM mutations and B12 deficiency.	Methylmalonic Acid	0-18	methylmalonyl-CoA mutase	Homo sapiens	108-111
8929440-10	1996	This study shows that methylmalonyl-CoA mutase is induced by several stresses, including ischemia, and would serve to decrease the accumulation of an endogenous cellular mitochondrial inhibitor and neurotoxin, methylmalonic acid.	Methylmalonic Acid	210-228	methylmalonyl-CoA mutase	Homo sapiens	22-46
8179199-1	1994	An isocratic reverse-phase C18 high-performance liquid chromatography (HPLC) technique for methylmalonic acid (MMA) with fluorescence detection is described.	Methylmalonic Acid	91-109	Bardet-Biedl syndrome 9	Homo sapiens	27-30
8741039-7	1996	Investigations for neurometabolic disorders in urine, plasma and CSF of both patients revealed a consistent increase of methylmalonic acid in urine, plasma and CSF as well as borderline low free GABA in CSF.	Methylmalonic Acid	120-138	colony stimulating factor 2	Homo sapiens	65-68
9384744-1	1996	Elevated methylmalonic acid (MMA) is a superior marker for cobalamin (vitamin B12) deficiency.	Methylmalonic Acid	9-27	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	78-81
9384744-1	1996	Elevated methylmalonic acid (MMA) is a superior marker for cobalamin (vitamin B12) deficiency.	Methylmalonic Acid	29-32	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	78-81
7482352-7	1995	There was a strong dose-response relationship between midtrimester serum MMA level and the risk for an NTD-affected pregnancy, with the relative risk increasing 13-fold for women with MMA levels > 90th percentile.	Methylmalonic Acid	73-76	fuzzy planar cell polarity protein	Homo sapiens	103-106
7482352-7	1995	There was a strong dose-response relationship between midtrimester serum MMA level and the risk for an NTD-affected pregnancy, with the relative risk increasing 13-fold for women with MMA levels > 90th percentile.	Methylmalonic Acid	184-187	fuzzy planar cell polarity protein	Homo sapiens	103-106
8602704-0	1996	Elevated methylmalonic acid and total homocysteine levels show high prevalence of vitamin B12 deficiency after gastric surgery.	Methylmalonic Acid	9-27	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	90-93
8602704-6	1996	Vitamin B12 deficiency was defined as one of the following: 1) a serum vitamin B12 level less than 221 pmol/L and an elevated methylmalonic acid level; 2) a serum vitamin B12 level less than 221 pmol/L and an elevated total homocysteine level that decreased with vitamin B12 treatment; or 3) in patients unavailable for treatment, a serum vitamin B12 level less than 221 pmol/L, a folate level greater than 9 nmol/L, and an elevated total homocysteine level.	Methylmalonic Acid	126-144	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
8602704-10	1996	In all participants with vitamin B12 deficiency who received treatment (15 of 21), methylmalonic acid and total homocysteine levels decreased substantially, confirming the deficiency before treatment.	Methylmalonic Acid	83-101	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	33-36
8875026-6	1996	Inadequate tissue availability of cobalamin results in increased concentration of methylmalonic acid and homocyst(e)ine due to inhibition of methylmalonyl-CoA mutase and methionine synthase, respectively.	Methylmalonic Acid	82-100	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	170-189
8179199-1	1994	An isocratic reverse-phase C18 high-performance liquid chromatography (HPLC) technique for methylmalonic acid (MMA) with fluorescence detection is described.	Methylmalonic Acid	111-114	Bardet-Biedl syndrome 9	Homo sapiens	27-30
2239784-4	1990	Infant urinary MMA excretion was inversely related to milk vitamin B-12 concentrations less than 362 pmol/L.	Methylmalonic Acid	15-18	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	67-71
8106575-0	1993	Quantification of methylmalonic acid in serum measured by capillary gas chromatography-mass spectrometry as tert.-butyldimethylsilyl derivatives.	Methylmalonic Acid	18-36	telomerase reverse transcriptase	Homo sapiens	108-112
8106575-2	1993	Methylmalonic acid was measured as tert.-butyldimethylsilyl derivatives formed in the presence of dimethylformamide.	Methylmalonic Acid	0-18	telomerase reverse transcriptase	Homo sapiens	35-39
1922806-1	1991	We measured methylmalonic acid, which accumulates in the blood and tissues of patients with cobalamin deficiency, in the CSF of 65 patients using capillary-gas chromatography and mass spectrometry.	Methylmalonic Acid	12-30	colony stimulating factor 2	Homo sapiens	121-124
1922806-2	1991	In 58 control patients, methylmalonic acid concentrations were always higher in CSF than in serum (mean CSF: serum ratio, 2.65; range, 1.17 to 7.78).	Methylmalonic Acid	24-42	colony stimulating factor 2	Homo sapiens	80-83
1922806-2	1991	In 58 control patients, methylmalonic acid concentrations were always higher in CSF than in serum (mean CSF: serum ratio, 2.65; range, 1.17 to 7.78).	Methylmalonic Acid	24-42	colony stimulating factor 2	Homo sapiens	104-107
1922806-3	1991	In contrast, in six patients with elevated serum methylmalonic acid levels due to renal failure, CSF concentrations were normal in five and the CSF: serum ratio was less than one in four.	Methylmalonic Acid	49-67	colony stimulating factor 2	Homo sapiens	97-100
1922806-3	1991	In contrast, in six patients with elevated serum methylmalonic acid levels due to renal failure, CSF concentrations were normal in five and the CSF: serum ratio was less than one in four.	Methylmalonic Acid	49-67	colony stimulating factor 2	Homo sapiens	144-147
1931558-7	1991	Methylmalonic acid could be detected and quantitated (ca 150 microM) in the CSF from the vitamin B12 deficient patient.	Methylmalonic Acid	0-18	colony stimulating factor 2	Homo sapiens	76-79
35361954-4	2022	The loss of MCEE results in reduced propionate-driven anaplerotic flux and intracellular and intratumoral accumulation of methylmalonic acid, a by-product of propionate metabolism that promotes cancer cell invasiveness.	Methylmalonic Acid	122-140	methylmalonyl-CoA epimerase	Homo sapiens	12-16
2278533-6	1990	In such patients, vitamin B12 deficiency is confirmed by determining serum levels of homocysteine and methylmalonic acid.	Methylmalonic Acid	102-120	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	26-29
34960774-0	2021	Knock-Out of Retrovirus Receptor Gene Tva in the Chicken Confers Resistance to Avian Leukosis Virus Subgroups A and K and Affects Cobalamin (Vitamin B12)-Dependent Level of Methylmalonic Acid.	Methylmalonic Acid	173-191	CD320 molecule	Gallus gallus	38-41
34147638-2	2021	MMACHC encodes an enzyme crucial for intracellular vitamin B12 metabolism, leading to the accumulation of toxic metabolites e.g. methylmalonic acid (MMA) and homocysteine (Hcy), and secondary disturbances in folate and one-carbon metabolism when not fully functional.	Methylmalonic Acid	129-147	methylmalonic aciduria cblC type, with homocystinuria	Mus musculus	0-6
34147638-2	2021	MMACHC encodes an enzyme crucial for intracellular vitamin B12 metabolism, leading to the accumulation of toxic metabolites e.g. methylmalonic acid (MMA) and homocysteine (Hcy), and secondary disturbances in folate and one-carbon metabolism when not fully functional.	Methylmalonic Acid	149-152	methylmalonic aciduria cblC type, with homocystinuria	Mus musculus	0-6
34191487-7	2021	Our results showed that MMA impairs the respiratory parameters only at the late stage of differentiation and downregulates the transcriptional gene profile of mature neuronal markers neuron-specific enolase (ENO2) and synaptophysin (SYP).	Methylmalonic Acid	24-27	enolase 2	Homo sapiens	183-206
34191487-7	2021	Our results showed that MMA impairs the respiratory parameters only at the late stage of differentiation and downregulates the transcriptional gene profile of mature neuronal markers neuron-specific enolase (ENO2) and synaptophysin (SYP).	Methylmalonic Acid	24-27	enolase 2	Homo sapiens	208-212
34191487-7	2021	Our results showed that MMA impairs the respiratory parameters only at the late stage of differentiation and downregulates the transcriptional gene profile of mature neuronal markers neuron-specific enolase (ENO2) and synaptophysin (SYP).	Methylmalonic Acid	24-27	synaptophysin	Homo sapiens	218-231
34191487-7	2021	Our results showed that MMA impairs the respiratory parameters only at the late stage of differentiation and downregulates the transcriptional gene profile of mature neuronal markers neuron-specific enolase (ENO2) and synaptophysin (SYP).	Methylmalonic Acid	24-27	synaptophysin	Homo sapiens	233-236
2372940-1	1990	The clinical value of measuring concentrations of methylmalonic acid in serum (S-MMA) as an aid in the diagnosis of cobalamin deficiency has recently aroused interest.	Methylmalonic Acid	50-68	activation induced cytidine deaminase	Homo sapiens	92-95
2212958-1	1990	It is well established that accumulation of methylmalonic acid may provide an early clue to the existence of tissue cobalamin (vitamin B12) deficiency.	Methylmalonic Acid	44-62	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	135-138
34340239-15	2021	CONCLUSIONS: The high-concentration methylmalonic acid in the blood induced immune cells to release pro-inflammatory cytokines such as TNF-alpha and IL-6.	Methylmalonic Acid	36-54	tumor necrosis factor	Homo sapiens	135-144
34340239-15	2021	CONCLUSIONS: The high-concentration methylmalonic acid in the blood induced immune cells to release pro-inflammatory cytokines such as TNF-alpha and IL-6.	Methylmalonic Acid	36-54	interleukin 6	Homo sapiens	149-153
35569737-5	2022	The MMAB cells produced little ATR, showed reduced residual ATR activity, and had higher concentrations of methylmalonic acid compared to healthy HLCs.	Methylmalonic Acid	107-125	metabolism of cobalamin associated B	Homo sapiens	4-8
35337623-10	2022	Elevation of metabolites homocysteine and methylmalonic acid occurs because the lack of an active CblC blocks formation of the indispensable precursor cob(II)alamin that is necessary to activate MS and MUT.	Methylmalonic Acid	42-60	Cbl proto-oncogene C	Homo sapiens	98-102