PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9877232-1	1998	Nucleoside diphosphate kinase (NDP kinase) catalyzes the transfer of terminal phosphate from nucleotide triphosphates (e.g. ATP) to nucleotide diphosphates (e.g. GDP) to yield nucleotide triphosphates (e.g. GTP).	nucleotide triphosphates	176-200	cytidine/uridine monophosphate kinase 1	Rattus norvegicus	0-29
9889120-6	1999	In this system, export is dependent on exogenous CRM1/Exportin1 - a nuclear export receptor - the GTPase Ran and nucleotide triphosphates (NTPs), and is further stimulated by Ran-binding protein 1 (RanBP1) and nuclear transport factor 2 (NTF2).	nucleotide triphosphates	113-137	exportin 1	Homo sapiens	49-53
9889120-6	1999	In this system, export is dependent on exogenous CRM1/Exportin1 - a nuclear export receptor - the GTPase Ran and nucleotide triphosphates (NTPs), and is further stimulated by Ran-binding protein 1 (RanBP1) and nuclear transport factor 2 (NTF2).	nucleotide triphosphates	113-137	exportin 1	Homo sapiens	54-63
9889120-6	1999	In this system, export is dependent on exogenous CRM1/Exportin1 - a nuclear export receptor - the GTPase Ran and nucleotide triphosphates (NTPs), and is further stimulated by Ran-binding protein 1 (RanBP1) and nuclear transport factor 2 (NTF2).	nucleotide triphosphates	113-137	RAN binding protein 1	Homo sapiens	175-196
9889120-6	1999	In this system, export is dependent on exogenous CRM1/Exportin1 - a nuclear export receptor - the GTPase Ran and nucleotide triphosphates (NTPs), and is further stimulated by Ran-binding protein 1 (RanBP1) and nuclear transport factor 2 (NTF2).	nucleotide triphosphates	113-137	RAN binding protein 1	Homo sapiens	198-204
9889120-6	1999	In this system, export is dependent on exogenous CRM1/Exportin1 - a nuclear export receptor - the GTPase Ran and nucleotide triphosphates (NTPs), and is further stimulated by Ran-binding protein 1 (RanBP1) and nuclear transport factor 2 (NTF2).	nucleotide triphosphates	113-137	nuclear transport factor 2	Homo sapiens	210-236
9889120-6	1999	In this system, export is dependent on exogenous CRM1/Exportin1 - a nuclear export receptor - the GTPase Ran and nucleotide triphosphates (NTPs), and is further stimulated by Ran-binding protein 1 (RanBP1) and nuclear transport factor 2 (NTF2).	nucleotide triphosphates	113-137	nuclear transport factor 2	Homo sapiens	238-242
9877232-1	1998	Nucleoside diphosphate kinase (NDP kinase) catalyzes the transfer of terminal phosphate from nucleotide triphosphates (e.g. ATP) to nucleotide diphosphates (e.g. GDP) to yield nucleotide triphosphates (e.g. GTP).	nucleotide triphosphates	93-117	cytidine/uridine monophosphate kinase 1	Rattus norvegicus	0-29
9877232-1	1998	Nucleoside diphosphate kinase (NDP kinase) catalyzes the transfer of terminal phosphate from nucleotide triphosphates (e.g. ATP) to nucleotide diphosphates (e.g. GDP) to yield nucleotide triphosphates (e.g. GTP).	nucleotide triphosphates	93-117	cytidine/uridine monophosphate kinase 1	Rattus norvegicus	31-41
9877232-1	1998	Nucleoside diphosphate kinase (NDP kinase) catalyzes the transfer of terminal phosphate from nucleotide triphosphates (e.g. ATP) to nucleotide diphosphates (e.g. GDP) to yield nucleotide triphosphates (e.g. GTP).	nucleotide triphosphates	176-200	cytidine/uridine monophosphate kinase 1	Rattus norvegicus	31-41
8446899-4	1993	Substitution of Asp138 with Asn in EF-Tu changed the substrate specificity from GTP to xanthosine triphosphate and demonstrated that the EF-Tu-mediated reactions involved the hydrolysis of two nucleotide triphosphates for each Phe incorporated.	nucleotide triphosphates	193-217	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	35-40
7918472-3	1994	Herein, we characterize nucleoside diphosphokinase (NDP kinase) activity, which catalyzes the transphosphorylation of nucleotide diphosphate (e.g., GDP) to nucleotide triphosphates (e.g., GTP) in insulin-secreting cells.	nucleotide triphosphates	156-180	insulin	Homo sapiens	196-203
8446899-4	1993	Substitution of Asp138 with Asn in EF-Tu changed the substrate specificity from GTP to xanthosine triphosphate and demonstrated that the EF-Tu-mediated reactions involved the hydrolysis of two nucleotide triphosphates for each Phe incorporated.	nucleotide triphosphates	193-217	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	137-142
1724243-4	1991	PD-ECGF becomes covalently associated with nucleotide triphosphates (e.g., ATP) in vivo, as well as in vitro.	nucleotide triphosphates	43-67	thymidine phosphorylase	Homo sapiens	0-7
35510477-3	2022	The results reveal a comparable binding affinity of sofosbuvir, galidesivir, ribavirin and remdesivir compared with the physiological nucleotide triphosphates against R. oryzae RdRp as well as the SARS-CoV-2 RdRp as reported before.	nucleotide triphosphates	134-158	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	177-181
34850656-8	2021	NNAIs neither require metabolic activation (unlike NAIs) nor compete with intracellular pool of nucleotide triphosphates (NTPs) for anti-RdRp activity.	nucleotide triphosphates	96-120	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	137-141
35494245-3	2022	In this network, 14 transcription factors, including Myc, coordinately upregulate the gene expression of anabolic processes such as nucleotide synthesis, transcription, and translation, consistent with decreases in metabolites such as nucleotide triphosphates and proteinogenic amino acids required for transcription and translation.	nucleotide triphosphates	235-259	Myc	Drosophila melanogaster	53-56
3539181-4	1986	Similar competition studies also showed that nearly all of the other nucleotide triphosphates also bind to recA protein, with the affinity decreasing in the following order: UTP greater than GTP approximately equal to dCTP greater than dGTP greater than CTP.	nucleotide triphosphates	69-93	RAD51 recombinase	Homo sapiens	107-111
16666820-7	1989	The cytoplasmic phosphofructokinase and fructokinase in plants were fairly nonselective for nucleotide triphosphates (NTP) but glucokinase definitely favored ATP.	nucleotide triphosphates	92-116	ketohexokinase	Homo sapiens	23-35
31302152-2	2019	Based on our finding of elevated biomolecule oxidation in mitotically arrested cancer cells, we combined Plk1 inhibitors with TH588, an MTH1 inhibitor that prevents detoxification of oxidized nucleotide triphosphates.	nucleotide triphosphates	192-216	nudix hydrolase 1	Homo sapiens	136-140
6758843-7	1982	The nucleotide triphosphates have converted the recA-epsilon DNA complex into the respective ATP gamma S-recA-epsilon DNA and ATP-recA-epsilon DNA complexes.	nucleotide triphosphates	4-28	RAD51 recombinase	Homo sapiens	48-52
6758843-7	1982	The nucleotide triphosphates have converted the recA-epsilon DNA complex into the respective ATP gamma S-recA-epsilon DNA and ATP-recA-epsilon DNA complexes.	nucleotide triphosphates	4-28	RAD51 recombinase	Homo sapiens	105-109
6758843-7	1982	The nucleotide triphosphates have converted the recA-epsilon DNA complex into the respective ATP gamma S-recA-epsilon DNA and ATP-recA-epsilon DNA complexes.	nucleotide triphosphates	4-28	RAD51 recombinase	Homo sapiens	105-109
6263316-2	1981	Both the rate and extent of inhibition are pH and temperature dependent and increase as the pH is lowered from pH 8 tp 6.7 (the lowest pH examined) or as the temperature is increased from 4 to 36 degrees C. Nucleotide triphosphates plus Mg2+ ions are required for inhibition of complex V ATPase activity by IF1.	nucleotide triphosphates	207-231	dynein axonemal heavy chain 8	Homo sapiens	288-294
6263316-2	1981	Both the rate and extent of inhibition are pH and temperature dependent and increase as the pH is lowered from pH 8 tp 6.7 (the lowest pH examined) or as the temperature is increased from 4 to 36 degrees C. Nucleotide triphosphates plus Mg2+ ions are required for inhibition of complex V ATPase activity by IF1.	nucleotide triphosphates	207-231	ATP synthase inhibitory factor subunit 1	Homo sapiens	307-310
33774493-1	2021	MutT Homolog 1 (MTH1) has been proven to hydrolyze oxidized nucleotide triphosphates during DNA repair.	nucleotide triphosphates	60-84	nudix hydrolase 1	Homo sapiens	0-14
33774493-1	2021	MutT Homolog 1 (MTH1) has been proven to hydrolyze oxidized nucleotide triphosphates during DNA repair.	nucleotide triphosphates	60-84	nudix hydrolase 1	Homo sapiens	16-20
26771665-1	2016	The dCTPase pyrophosphatase 1 (dCTPase) regulates the intracellular nucleotide pool through hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs).	nucleotide triphosphates	145-169	inorganic pyrophosphatase 1	Homo sapiens	12-29
30569141-1	2019	Human MutT homolog 1 (MTH1) hydrolyses oxidised nucleotide triphosphates, thereby preventing them from being incorporated into DNA; MTH1 has been found to be elevated in many types of cancers, including lung, stomach cancer, melanoma and breast cancer.	nucleotide triphosphates	48-72	nudix hydrolase 1	Homo sapiens	6-20
30569141-1	2019	Human MutT homolog 1 (MTH1) hydrolyses oxidised nucleotide triphosphates, thereby preventing them from being incorporated into DNA; MTH1 has been found to be elevated in many types of cancers, including lung, stomach cancer, melanoma and breast cancer.	nucleotide triphosphates	48-72	nudix hydrolase 1	Homo sapiens	22-26
30569141-1	2019	Human MutT homolog 1 (MTH1) hydrolyses oxidised nucleotide triphosphates, thereby preventing them from being incorporated into DNA; MTH1 has been found to be elevated in many types of cancers, including lung, stomach cancer, melanoma and breast cancer.	nucleotide triphosphates	48-72	nudix hydrolase 1	Homo sapiens	132-136
25260930-1	2014	Ecto-nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyse nucleotide triphosphates to the corresponding nucleotide monophosphates and the mineralisation inhibitor, pyrophosphate (PPi).	nucleotide triphosphates	68-92	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	0-50
25927932-3	2015	SAM domain and HD domain-containing protein 1 (SAMHD1) degrades nucleotide triphosphates and controls the size of the dNTP pool.	nucleotide triphosphates	64-88	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	47-53
25260930-1	2014	Ecto-nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyse nucleotide triphosphates to the corresponding nucleotide monophosphates and the mineralisation inhibitor, pyrophosphate (PPi).	nucleotide triphosphates	68-92	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	52-56
23027977-1	2012	Enpp1 is a membrane-bound glycoprotein that regulates bone mineralization by hydrolyzing extracellular nucleotide triphosphates to produce pyrophosphate.	nucleotide triphosphates	103-127	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	0-5
23927463-5	2013	Here, we report the use of terminal deoxynucleotidyl transferase (TdT) for direct enzymatic ligation of native DNA to nucleotide triphosphates coupled to proteins and other large macromolecules.	nucleotide triphosphates	118-142	DNA nucleotidylexotransferase	Homo sapiens	27-64
23927463-5	2013	Here, we report the use of terminal deoxynucleotidyl transferase (TdT) for direct enzymatic ligation of native DNA to nucleotide triphosphates coupled to proteins and other large macromolecules.	nucleotide triphosphates	118-142	DNA nucleotidylexotransferase	Homo sapiens	66-69
24722905-0	2014	Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates.	nucleotide triphosphates	103-127	alkaline phosphatase 3, intestine, not Mn requiring	Mus musculus	0-31
24722905-9	2014	IAP promotes the growth of stool aerobic and anaerobic bacteria and appears to exert its growth promoting effects by inactivating (dephosphorylating) luminal ATP and other luminal nucleotide triphosphates.	nucleotide triphosphates	180-204	alkaline phosphatase 3, intestine, not Mn requiring	Mus musculus	0-3
24722905-11	2014	In conclusion, IAP appears to promote the growth of intestinal commensal bacteria by inhibiting the concentration of luminal nucleotide triphosphates.	nucleotide triphosphates	125-149	alkaline phosphatase 3, intestine, not Mn requiring	Mus musculus	15-18
17011188-0	2007	Novel nucleotide triphosphates as potent P2Y2 agonists.	nucleotide triphosphates	6-30	purinergic receptor P2Y2	Homo sapiens	41-45
21102543-3	2011	This extracellular pyrophosphate originates either from the breakdown of nucleotide triphosphates by plasma-cell membrane glycoprotein 1 (PC-1) or from pyrophosphate transport by the transmembrane protein progressive ankylosis protein homolog (ANK).	nucleotide triphosphates	73-97	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	101-136
21102543-3	2011	This extracellular pyrophosphate originates either from the breakdown of nucleotide triphosphates by plasma-cell membrane glycoprotein 1 (PC-1) or from pyrophosphate transport by the transmembrane protein progressive ankylosis protein homolog (ANK).	nucleotide triphosphates	73-97	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	138-142
19563117-3	2009	They use energy derived from the hydrolysis of nucleotide triphosphates for both bond breakage between complementary bases and translocation of a helicase enzyme along DNA.	nucleotide triphosphates	47-71	helicase for meiosis 1	Homo sapiens	146-154
21787772-1	2011	MTH1 hydrolyzes oxidized nucleotide triphosphates, thereby preventing them from being incorporated into DNA.	nucleotide triphosphates	25-49	nudix hydrolase 1	Homo sapiens	0-4
19399589-9	2009	Although histidine phosphorylation should in principle be independent of the nucleotide triphosphates used, we speculate that this membrane pool of NDPK may be able to switch function dependent on nucleotide species.	nucleotide triphosphates	77-101	cytidine/uridine monophosphate kinase 2	Homo sapiens	148-152
17569759-8	2007	We also found that osteoblasts express ectonucleotide phosphodiesterase/pyrophosphatase-1, an ectonucleotidase that hydrolyzes nucleotide triphosphates to yield PPi, and that addition of 10 microm ATP or UTP to osteoblast cultures generated 2 microm PPi within 10 min.	nucleotide triphosphates	127-151	inorganic pyrophosphatase 1	Rattus norvegicus	72-89
17092635-0	2007	The respiratory effects of stanniocalcin-1 (STC-1) on intact mitochondria and cells: STC-1 uncouples oxidative phosphorylation and its actions are modulated by nucleotide triphosphates.	nucleotide triphosphates	160-184	stanniocalcin 1	Homo sapiens	27-42
17092635-0	2007	The respiratory effects of stanniocalcin-1 (STC-1) on intact mitochondria and cells: STC-1 uncouples oxidative phosphorylation and its actions are modulated by nucleotide triphosphates.	nucleotide triphosphates	160-184	stanniocalcin 1	Homo sapiens	44-49
17092635-0	2007	The respiratory effects of stanniocalcin-1 (STC-1) on intact mitochondria and cells: STC-1 uncouples oxidative phosphorylation and its actions are modulated by nucleotide triphosphates.	nucleotide triphosphates	160-184	stanniocalcin 1	Homo sapiens	85-90
11831846-1	2002	Nucleoside diphosphate kinase (NDPK) catalyzes the transfer of terminal phosphates from nucleoside triphosphates to nucleoside diphosphates to yield nucleotide triphosphates.	nucleotide triphosphates	149-173	cytidine/uridine monophosphate kinase 2	Homo sapiens	0-29
17092635-12	2007	In the presence of nucleotide triphosphates such as ATP and GTP (5mM) the respiratory effects of STC-1 were attenuated or abolished.	nucleotide triphosphates	19-43	stanniocalcin 1	Homo sapiens	97-102
17092635-14	2007	The results suggest that STC-1 stimulates mitochondrial electron transport chain activity and calcium transport, and that these effects are negatively modulated by nucleotide triphosphates.	nucleotide triphosphates	164-188	stanniocalcin 1	Homo sapiens	25-30
15182186-4	2004	Compared to those of the other hydrolyzable nucleotide triphosphates, the ATPase activity of Lon is also the most sensitive to peptide stimulation.	nucleotide triphosphates	44-68	putative ATP-dependent Lon protease	Escherichia coli	93-96
12637029-2	2003	At pH 7.5, NTPDase1 hydrolyzed nucleotide triphosphates at rates 2.4-fold higher than those of nucleotide diphosphates, while the hydrolysis of nucleotide monophosphates and non-nucleotide phosphates was negligible.	nucleotide triphosphates	31-55	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	11-19
12064539-8	2002	Furthermore, we used the new method for monitoring enzymatic studies using the enzyme hexokinase to convert nucleotide triphosphates to diphosphates.	nucleotide triphosphates	108-132	hexokinase 1	Homo sapiens	86-96
17079144-0	2007	Novel nucleotide triphosphates as potent P2Y2 agonists with enhanced stability over UTP.	nucleotide triphosphates	6-30	purinergic receptor P2Y2	Homo sapiens	41-45
11831846-1	2002	Nucleoside diphosphate kinase (NDPK) catalyzes the transfer of terminal phosphates from nucleoside triphosphates to nucleoside diphosphates to yield nucleotide triphosphates.	nucleotide triphosphates	149-173	cytidine/uridine monophosphate kinase 2	Homo sapiens	31-35
11831846-2	2002	The present study was undertaken to localize and characterize the mitochondrial isoform of NDPK (mNDPK) in the pancreatic beta cell since it could contribute to the generation of mitochondrial nucleotide triphosphates and, thereby, to the mitochondrial high-energy phosphate metabolism of the pancreatic beta cell.	nucleotide triphosphates	193-217	cytidine/uridine monophosphate kinase 2	Homo sapiens	91-95
11694445-0	2001	Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates.	nucleotide triphosphates	93-117	LOC100508689	Homo sapiens	34-39
11694445-0	2001	Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates.	nucleotide triphosphates	93-117	LOC100508689	Homo sapiens	60-65
11694445-1	2001	The effects of extracellular nucleotide triphosphates on the stimulation of mucin production by airway epithelial cells were examined.	nucleotide triphosphates	29-53	LOC100508689	Homo sapiens	76-81