PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34603597-6	2021	Furthermore, mechanistic research revealed that sitogluside is capable of downregulating tyrosinase (TYR) expression by inhibiting the ERK and p38 pathways and inhibiting TYR activity.	lyoniside	48-59	tyrosinase	Homo sapiens	89-99
34603597-6	2021	Furthermore, mechanistic research revealed that sitogluside is capable of downregulating tyrosinase (TYR) expression by inhibiting the ERK and p38 pathways and inhibiting TYR activity.	lyoniside	48-59	tyrosinase	Homo sapiens	101-104
34603597-6	2021	Furthermore, mechanistic research revealed that sitogluside is capable of downregulating tyrosinase (TYR) expression by inhibiting the ERK and p38 pathways and inhibiting TYR activity.	lyoniside	48-59	mitogen-activated protein kinase 1	Homo sapiens	135-138
34603597-6	2021	Furthermore, mechanistic research revealed that sitogluside is capable of downregulating tyrosinase (TYR) expression by inhibiting the ERK and p38 pathways and inhibiting TYR activity.	lyoniside	48-59	mitogen-activated protein kinase 14	Homo sapiens	143-146
34603597-6	2021	Furthermore, mechanistic research revealed that sitogluside is capable of downregulating tyrosinase (TYR) expression by inhibiting the ERK and p38 pathways and inhibiting TYR activity.	lyoniside	48-59	tyrosinase	Homo sapiens	171-174
34603597-8	2021	Sitogluside is a novel skin-whitening active ingredient with dual regulatory effects that inhibit TYR expression and activity.	lyoniside	0-11	tyrosinase	Homo sapiens	98-101
34484411-14	2021	Molecular docking results showed that daucosterol, delusive, dioxin, and panthogenin-B had the highest affinity for TP53, RPS27A, and UBC.	lyoniside	38-49	tumor protein p53	Homo sapiens	116-120
34484411-14	2021	Molecular docking results showed that daucosterol, delusive, dioxin, and panthogenin-B had the highest affinity for TP53, RPS27A, and UBC.	lyoniside	38-49	ribosomal protein S27a	Homo sapiens	122-128
34484411-14	2021	Molecular docking results showed that daucosterol, delusive, dioxin, and panthogenin-B had the highest affinity for TP53, RPS27A, and UBC.	lyoniside	38-49	ubiquitin C	Homo sapiens	134-137
35221674-7	2022	Molecular docking analysis found that the active components beta-amyrin, cajanin, eleutheroside A have high affinity for TNF-alpha, VEGFA, IL-2, AKT, and PI3K, etc.	lyoniside	82-97	tumor necrosis factor	Rattus norvegicus	121-130
35221674-7	2022	Molecular docking analysis found that the active components beta-amyrin, cajanin, eleutheroside A have high affinity for TNF-alpha, VEGFA, IL-2, AKT, and PI3K, etc.	lyoniside	82-97	vascular endothelial growth factor A	Rattus norvegicus	132-137
35221674-7	2022	Molecular docking analysis found that the active components beta-amyrin, cajanin, eleutheroside A have high affinity for TNF-alpha, VEGFA, IL-2, AKT, and PI3K, etc.	lyoniside	82-97	interleukin 2	Rattus norvegicus	139-143
35221674-7	2022	Molecular docking analysis found that the active components beta-amyrin, cajanin, eleutheroside A have high affinity for TNF-alpha, VEGFA, IL-2, AKT, and PI3K, etc.	lyoniside	82-97	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
33426081-6	2020	Results: The active components of ZR-CR-shogaol, daucosterol, ginkgetin, berberine, quercetin, chlorogenic acid, and vanillic acid-exhibited antitumor activities via the MAPK, PI3K-AKT, TNF, FOXO, HIF-1, and VEGF signaling pathways.	lyoniside	49-60	AKT serine/threonine kinase 1	Homo sapiens	181-184
33426081-6	2020	Results: The active components of ZR-CR-shogaol, daucosterol, ginkgetin, berberine, quercetin, chlorogenic acid, and vanillic acid-exhibited antitumor activities via the MAPK, PI3K-AKT, TNF, FOXO, HIF-1, and VEGF signaling pathways.	lyoniside	49-60	tumor necrosis factor	Homo sapiens	186-189
33426081-6	2020	Results: The active components of ZR-CR-shogaol, daucosterol, ginkgetin, berberine, quercetin, chlorogenic acid, and vanillic acid-exhibited antitumor activities via the MAPK, PI3K-AKT, TNF, FOXO, HIF-1, and VEGF signaling pathways.	lyoniside	49-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	197-202
33426081-6	2020	Results: The active components of ZR-CR-shogaol, daucosterol, ginkgetin, berberine, quercetin, chlorogenic acid, and vanillic acid-exhibited antitumor activities via the MAPK, PI3K-AKT, TNF, FOXO, HIF-1, and VEGF signaling pathways.	lyoniside	49-60	vascular endothelial growth factor A	Homo sapiens	208-212
33054569-9	2022	Another five compounds showed stronger docking scores against AChE than the clinically used donepezil including the most active isolated compound daucosterol (44), with a binding affinity of -10.11 kJ/mol towards AChE.	lyoniside	146-157	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-66
33054569-9	2022	Another five compounds showed stronger docking scores against AChE than the clinically used donepezil including the most active isolated compound daucosterol (44), with a binding affinity of -10.11 kJ/mol towards AChE.	lyoniside	146-157	acetylcholinesterase (Cartwright blood group)	Homo sapiens	213-217
32630623-4	2020	The experimental results of the analysis of the bioactive compounds revealed that beta-sitosterol (beta-S) and beta-sitosterol-glucoside (beta-SG) were the main ingredients of the I. zollingeriana extract.	lyoniside	111-136	SPGF2	Homo sapiens	138-145
32321590-1	2020	The spreading and accumulation of alpha-synuclein and dopaminergic neurodegeneration, two hallmarks of Parkinson"s disease (PD), have been faithfully reproduced in rodent brains by chronic, oral administration of beta-sitosterol beta-D-glucoside (BSSG).	lyoniside	247-251	synuclein alpha	Rattus norvegicus	34-49
31560992-5	2020	To investigate if the bioactive compound daucosterol (CA2) accounted for the previously observed anticancer effects of the C. adansonii extract, it was tested on cell growth, cell proliferation, cell cycle, cell death mechanism and cell migration.	lyoniside	41-52	carbonic anhydrase 2	Homo sapiens	54-57
31560992-7	2020	RESULTS: Daucosterol (CA2), a steroid saponin, was identified as major anticancer principle of the C. adansonii extract.	lyoniside	9-20	carbonic anhydrase 2	Homo sapiens	22-25
31894743-5	2020	However, after analyzing the binding energy (DeltaG), the documented data shows that bacoside X, bacoside A, 3-beta-D-glucosylstigmasterol and daucosterol could be good inhibitors in the inhibition of AChE and BuChE activities.	lyoniside	143-154	acetylcholinesterase (Cartwright blood group)	Homo sapiens	201-205
31894743-5	2020	However, after analyzing the binding energy (DeltaG), the documented data shows that bacoside X, bacoside A, 3-beta-D-glucosylstigmasterol and daucosterol could be good inhibitors in the inhibition of AChE and BuChE activities.	lyoniside	143-154	butyrylcholinesterase	Homo sapiens	210-215
31059712-0	2019	Daucosterol disturbs redox homeostasis and elicits oxidative-stress mediated apoptosis in A549 cells via targeting thioredoxin reductase by a p53 dependent mechanism.	lyoniside	0-11	peroxiredoxin 5	Homo sapiens	115-136
31059712-0	2019	Daucosterol disturbs redox homeostasis and elicits oxidative-stress mediated apoptosis in A549 cells via targeting thioredoxin reductase by a p53 dependent mechanism.	lyoniside	0-11	tumor protein p53	Homo sapiens	142-145
31059712-5	2019	Further DS elicits increased reactive oxygen species level and promote intrinsic apoptotic cell death on A549 cells as evidenced by increased expression of caspase-3, caspase-9, Bax, PARP inactivation, cytochrome-c release, and diminished expression of bcl-2 protein.	lyoniside	8-10	caspase 3	Homo sapiens	156-165
31059712-5	2019	Further DS elicits increased reactive oxygen species level and promote intrinsic apoptotic cell death on A549 cells as evidenced by increased expression of caspase-3, caspase-9, Bax, PARP inactivation, cytochrome-c release, and diminished expression of bcl-2 protein.	lyoniside	8-10	caspase 9	Homo sapiens	167-176
31059712-5	2019	Further DS elicits increased reactive oxygen species level and promote intrinsic apoptotic cell death on A549 cells as evidenced by increased expression of caspase-3, caspase-9, Bax, PARP inactivation, cytochrome-c release, and diminished expression of bcl-2 protein.	lyoniside	8-10	BCL2 associated X, apoptosis regulator	Homo sapiens	178-181
31059712-5	2019	Further DS elicits increased reactive oxygen species level and promote intrinsic apoptotic cell death on A549 cells as evidenced by increased expression of caspase-3, caspase-9, Bax, PARP inactivation, cytochrome-c release, and diminished expression of bcl-2 protein.	lyoniside	8-10	collagen type XI alpha 2 chain	Homo sapiens	183-187
31059712-5	2019	Further DS elicits increased reactive oxygen species level and promote intrinsic apoptotic cell death on A549 cells as evidenced by increased expression of caspase-3, caspase-9, Bax, PARP inactivation, cytochrome-c release, and diminished expression of bcl-2 protein.	lyoniside	8-10	BCL2 apoptosis regulator	Homo sapiens	253-258
31059712-8	2019	In addition, DS preferentially inhibited the cell growth of p53 wild-type NSCLC cell lines than the mutant p53 models.	lyoniside	13-15	tumor protein p53	Homo sapiens	60-63
30978647-7	2019	Mice with colitis showed a decreased population of Foxp3+ cells, which was upregulated by daucosterol treatment.	lyoniside	90-101	forkhead box P3	Mus musculus	51-56
30944266-0	2019	Daucosterol induces autophagic-dependent apoptosis in prostate cancer via JNK activation.	lyoniside	0-11	mitogen-activated protein kinase 8	Homo sapiens	74-77
30944266-6	2019	Additionally, treatment with daucosterol resulted in increased phosphorylation of c-Jun N-terminal kinase (JNK).	lyoniside	29-40	mitogen-activated protein kinase 8	Homo sapiens	82-105
30944266-6	2019	Additionally, treatment with daucosterol resulted in increased phosphorylation of c-Jun N-terminal kinase (JNK).	lyoniside	29-40	mitogen-activated protein kinase 8	Homo sapiens	107-110
30944266-7	2019	Furthermore, pre-treatment with a JNK-specific inhibitor SP600125 abated daucosterol-elicited autophagy and apoptotic cell death.	lyoniside	73-84	mitogen-activated protein kinase 8	Homo sapiens	34-37
30944266-8	2019	Taken together, our findings demonstrated that daucosterol blocked prostate cancer growth at least partly through inducing autophagic-dependent apoptosis via activating JNK signaling, providing a promising candidate for the development of antitumor drugs in prostate cancer treatment.	lyoniside	47-58	mitogen-activated protein kinase 8	Homo sapiens	169-172
28574485-0	2017	Daucosterol Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Wnt/beta-Catenin Signaling.	lyoniside	0-11	catenin beta 1	Homo sapiens	106-118
28574485-2	2017	The purpose of this study was to determine the effects of daucosterol on HCC by investigating Wnt/beta-catenin signaling.	lyoniside	58-69	catenin beta 1	Homo sapiens	98-110
28574485-7	2017	In addition, daucosterol reduced the levels of beta-catenin and p-beta-catenin in HepG2 and SMMC-7721 cells.	lyoniside	13-24	catenin beta 1	Homo sapiens	47-59
28574485-7	2017	In addition, daucosterol reduced the levels of beta-catenin and p-beta-catenin in HepG2 and SMMC-7721 cells.	lyoniside	13-24	catenin beta 1	Homo sapiens	66-78
28574485-10	2017	These findings indicated that daucosterol inhibited cell migration and invasion in HCC cells via the Wnt/beta-catenin signaling pathway.	lyoniside	30-41	catenin beta 1	Homo sapiens	105-117
26874034-9	2016	Dau pretreatment resulted in further increases of H2O2-induced enhancement in levels of CAT and SOD2.	lyoniside	0-3	catalase	Homo sapiens	88-91
26874034-9	2016	Dau pretreatment resulted in further increases of H2O2-induced enhancement in levels of CAT and SOD2.	lyoniside	0-3	superoxide dismutase 2	Homo sapiens	96-100
26874034-10	2016	Pretreatment with Dau, Pec, and Ast inhibited phosphorylation of MAPK, such as extracellular protein regulated protein kinase, p38, and c-Jun N-terminal kinase by H2O2.	lyoniside	18-21	mitogen-activated protein kinase 14	Homo sapiens	127-130
26209138-5	2015	LC3 (microtubule-associated protein 1 light chain 3)-II conversion was monitored with immunofluorescence and immunoblotting to demonstrate daucosterol-induced autophagy.	lyoniside	139-150	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	0-3
26209138-9	2015	Treatment with ROS scavenger GSH (reduced glutathione), NAC (N-acetyl-l-cysteine) or autophagy inhibitor 3-Methyladenine (3-MA) counteracted daucosterol-induced autophagy and growth inhibition in BGC823 and MCF-7 cancer cells.	lyoniside	141-152	X-linked Kx blood group	Homo sapiens	56-59
25864625-0	2015	Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway.	lyoniside	0-11	insulin like growth factor 1	Homo sapiens	106-110
25864625-1	2015	We previously reported that daucosterol (a sterolin) up-regulates the expression of insulin-like growth factor I (IGF1)(1) protein in neural stem cells.	lyoniside	28-39	insulin like growth factor 1	Homo sapiens	84-112
25864625-1	2015	We previously reported that daucosterol (a sterolin) up-regulates the expression of insulin-like growth factor I (IGF1)(1) protein in neural stem cells.	lyoniside	28-39	insulin like growth factor 1	Homo sapiens	114-118
25864625-1	2015	We previously reported that daucosterol (a sterolin) up-regulates the expression of insulin-like growth factor I (IGF1)(1) protein in neural stem cells.	lyoniside	43-51	insulin like growth factor 1	Homo sapiens	84-112
25864625-1	2015	We previously reported that daucosterol (a sterolin) up-regulates the expression of insulin-like growth factor I (IGF1)(1) protein in neural stem cells.	lyoniside	43-51	insulin like growth factor 1	Homo sapiens	114-118
25864625-3	2015	The results showed that post-treatment of daucosterol significantly reduced neuronal loss, as well as apoptotic rate and caspase-3 activity, displaying the neuroprotective activity.	lyoniside	42-53	caspase 3	Homo sapiens	121-130
25864625-4	2015	We also found that daucosterol increased the expression level of IGF1 protein, diminished the down-regulation of p-AKT(3) and p-GSK-3beta(4), thus activating the AKT(5) signal pathway.	lyoniside	19-30	insulin like growth factor 1	Homo sapiens	65-69
25864625-6	2015	The neuroprotective effect of daucosterol was inhibited in the presence of picropodophyllin (PPP)(9), the inhibitor of insulin-like growth factor I receptors (IGF1R)(10).	lyoniside	30-41	insulin like growth factor 1	Homo sapiens	119-147
25864625-6	2015	The neuroprotective effect of daucosterol was inhibited in the presence of picropodophyllin (PPP)(9), the inhibitor of insulin-like growth factor I receptors (IGF1R)(10).	lyoniside	30-41	insulin like growth factor 1 receptor	Homo sapiens	159-164
25864625-7	2015	Our study provided information about daucosterol as an efficient and inexpensive neuroprotectants, to which the IGF1-like activity of daucosterol contributes.	lyoniside	37-48	insulin like growth factor 1	Homo sapiens	112-116
25864625-7	2015	Our study provided information about daucosterol as an efficient and inexpensive neuroprotectants, to which the IGF1-like activity of daucosterol contributes.	lyoniside	134-145	insulin like growth factor 1	Homo sapiens	112-116
24811295-2	2014	RECENT FINDINGS: Sitosterolemia is caused by a genetic defect of sterolins (ABCG5/ABCG8) mapped to the STSL locus.	lyoniside	65-74	ATP binding cassette subfamily G member 5	Homo sapiens	76-81
24811295-2	2014	RECENT FINDINGS: Sitosterolemia is caused by a genetic defect of sterolins (ABCG5/ABCG8) mapped to the STSL locus.	lyoniside	65-74	ATP binding cassette subfamily G member 8	Homo sapiens	82-87
24333794-3	2014	Results of cell counting kit-8 (CCK-8) assay showed that daucosterol significantly increased the quantity of viable cells and the effectiveness of daucosterol was similar to that of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF).	lyoniside	57-68	epidermal growth factor	Homo sapiens	249-252
24333794-8	2014	In addition, the phosphorylation of AKT was increased, indicating that the proliferation-enhancing activity of daucosterol may be involved in IGF1-AKT pathway.	lyoniside	111-122	AKT serine/threonine kinase 1	Homo sapiens	36-39
24333794-8	2014	In addition, the phosphorylation of AKT was increased, indicating that the proliferation-enhancing activity of daucosterol may be involved in IGF1-AKT pathway.	lyoniside	111-122	insulin like growth factor 1	Homo sapiens	142-146
24333794-8	2014	In addition, the phosphorylation of AKT was increased, indicating that the proliferation-enhancing activity of daucosterol may be involved in IGF1-AKT pathway.	lyoniside	111-122	AKT serine/threonine kinase 1	Homo sapiens	147-150
24088519-1	2013	The miscibility behavior of palmitoyl sphingomyelin (PSM) with phytosterol derivatives of beta-sitosterol (SITO), beta-sitosteryl glucoside (SG), and beta-sitosteryl glucoside palmitate (SGP) was systematically investigated using Langmuir monolayers.	lyoniside	114-139	folate hydrolase 1B (pseudogene)	Homo sapiens	53-56
18196479-7	2008	CD-1 mice fed mouse chow pellets containing BSSG for 15 weeks showed motor deficits and motor neuron loss in the lumbar and thoracic spinal cord, along with decreased glutamate transporter labelling, and increased glial fibrillary acid protein reactivity.	lyoniside	44-48	CD1 antigen complex	Mus musculus	0-4
17335944-0	2007	Immunoregulatory activity by daucosterol, a beta-sitosterol glycoside, induces protective Th1 immune response against disseminated Candidiasis in mice.	lyoniside	29-40	negative elongation factor complex member C/D, Th1l	Mus musculus	90-93
15246101-2	2004	Bioassay-guided fractionation of these extracts led to the isolation of three DNA polymerase beta lyase inhibitory phytosterols, namely stigmasterol (1) and beta-sitosterol (2), isolated from the hexanes extracts, and beta-sitosterol-beta-d-glucoside (3), isolated from the methyl ethyl ketone extract.	lyoniside	218-250	DNA polymerase beta	Homo sapiens	78-97
11237407-6	2001	The results indicate that HIV-infected patients on no therapy exhibit a pre-dominant Th2 response (IL-4 secretion), whereas those on the sterol/sterolin mixture exhibit a beneficial Th1 response (IFN-gamma).	lyoniside	144-152	negative elongation factor complex member C/D	Homo sapiens	182-185
11237407-6	2001	The results indicate that HIV-infected patients on no therapy exhibit a pre-dominant Th2 response (IL-4 secretion), whereas those on the sterol/sterolin mixture exhibit a beneficial Th1 response (IFN-gamma).	lyoniside	144-152	interferon gamma	Homo sapiens	196-205
11237407-8	2001	It appears that the detrimental Th2 driven response might be swung to the more beneficial Th1 response with the immune modulatory sterols/sterolin mixture.	lyoniside	138-146	negative elongation factor complex member C/D	Homo sapiens	90-93
10763582-7	2000	Compounds 5 (beta-sitosterol) and 6 (daucosterine), especially 5, completely blocked such an increased activation of PTK induced by H/R.	lyoniside	37-49	EPH receptor A8	Homo sapiens	117-120