PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29211798-7	2017	Muropeptides released from the PG of the lipl21- mutant, or prepared using a procedure to eliminate the LipL21 protein from the PG of the parental strain, were recognized in vitro by the human NOD1 (hNOD1) and NOD2 (hNOD2) receptors, suggesting that LipL21 protects PG from degradation into muropeptides.	muropeptides	291-303	nucleotide binding oligomerization domain containing 1	Homo sapiens	193-197
28734616-4	2018	A subset of eSTKs are single-pass transmembrane proteins that have extracellular penicillin-binding-protein and serine/threonine kinase-associated (PASTA) domains which bind muropeptides.	muropeptides	174-186	solute carrier family 45 member 1	Homo sapiens	148-153
28434881-6	2017	NOD1-activating muropeptides worsened glucose tolerance.	muropeptides	16-28	nucleotide-binding oligomerization domain containing 1	Mus musculus	0-4
22330585-2	2012	NOD2, an intracellular pathogen recognition sensor, modulates innate defence to muropeptides derived from various bacterial species.	muropeptides	80-92	nucleotide binding oligomerization domain containing 2	Homo sapiens	0-4
27513337-7	2016	NOD2 accepts muropeptides with long and branched peptide chains and requires an intact N-acetylmuramyl residue.	muropeptides	13-25	nucleotide binding oligomerization domain containing 2	Homo sapiens	0-4
27513337-8	2016	Muropeptides with non-terminal meso-DAP can activate NOD1 as well, but, in this case, probably require peptidase pre-processing to expose the meso-DAP residue.	muropeptides	0-12	nucleotide binding oligomerization domain containing 1	Homo sapiens	53-57
27513337-9	2016	Depending on NOD1/NOD2 ratio in specific cell types, meso-DAP-containing muropeptides can be recognized either primarily via NOD2 (in monocytes) or via NOD1 (in monocyte-derived macrophages and HEK293T-derived cells).	muropeptides	73-85	nucleotide binding oligomerization domain containing 1	Homo sapiens	13-17
27513337-9	2016	Depending on NOD1/NOD2 ratio in specific cell types, meso-DAP-containing muropeptides can be recognized either primarily via NOD2 (in monocytes) or via NOD1 (in monocyte-derived macrophages and HEK293T-derived cells).	muropeptides	73-85	nucleotide binding oligomerization domain containing 2	Homo sapiens	18-22
27513337-9	2016	Depending on NOD1/NOD2 ratio in specific cell types, meso-DAP-containing muropeptides can be recognized either primarily via NOD2 (in monocytes) or via NOD1 (in monocyte-derived macrophages and HEK293T-derived cells).	muropeptides	73-85	nucleotide binding oligomerization domain containing 2	Homo sapiens	125-129
27513337-9	2016	Depending on NOD1/NOD2 ratio in specific cell types, meso-DAP-containing muropeptides can be recognized either primarily via NOD2 (in monocytes) or via NOD1 (in monocyte-derived macrophages and HEK293T-derived cells).	muropeptides	73-85	nucleotide binding oligomerization domain containing 1	Homo sapiens	152-156
27513337-10	2016	The dual NOD1/NOD2 agonism of meso-DAP-containing muropeptides should be taken into account when assessing cellular responses to muropeptides and designing muropeptide immunostimulants and vaccine adjuvants.	muropeptides	50-62	nucleotide binding oligomerization domain containing 1	Homo sapiens	9-13
27513337-10	2016	The dual NOD1/NOD2 agonism of meso-DAP-containing muropeptides should be taken into account when assessing cellular responses to muropeptides and designing muropeptide immunostimulants and vaccine adjuvants.	muropeptides	50-62	nucleotide binding oligomerization domain containing 2	Homo sapiens	14-18
28087669-1	2017	Activation of nucleotide-binding oligomerization domain (NOD) 1 and NOD2 by muropeptides triggers a complex transcriptional program in innate immune cells.	muropeptides	76-88	nucleotide binding oligomerization domain containing 2	Homo sapiens	68-72
27513337-0	2016	The Dual NOD1/NOD2 Agonism of Muropeptides Containing a Meso-Diaminopimelic Acid Residue.	muropeptides	30-42	nucleotide binding oligomerization domain containing 1	Homo sapiens	9-13
27513337-0	2016	The Dual NOD1/NOD2 Agonism of Muropeptides Containing a Meso-Diaminopimelic Acid Residue.	muropeptides	30-42	nucleotide binding oligomerization domain containing 2	Homo sapiens	14-18
27513337-4	2016	Here, we developed a novel system to assess biological activity of muropeptides, based on CRISPR/Cas9-mediated knockout (KO) of NOD1 and NOD2 genes in modified HEK293T cells.	muropeptides	67-79	nucleotide binding oligomerization domain containing 1	Homo sapiens	128-132
27513337-4	2016	Here, we developed a novel system to assess biological activity of muropeptides, based on CRISPR/Cas9-mediated knockout (KO) of NOD1 and NOD2 genes in modified HEK293T cells.	muropeptides	67-79	nucleotide binding oligomerization domain containing 2	Homo sapiens	137-141
27513337-6	2016	We show that NOD2 can recognize different natural muropeptides containing a meso-DAP residue (preferably in a non-terminal position), provided they are present at micromolar concentrations.	muropeptides	50-62	nucleotide binding oligomerization domain containing 2	Homo sapiens	13-17
23873916-10	2013	Furthermore, MurM-deficient mutants, i.e., mutants lacking the ability to synthesize branched muropeptides, were found to require much higher levels of PBP2b to sustain growth than those required by MurM-proficient strains.	muropeptides	94-106	pbp2b	Streptococcus pneumoniae R6	152-157
17145940-2	2007	It is shown that a number of these muropeptides can induce tumor necrosis factor alpha (TNF-alpha) gene expression without significant TNF-alpha translation.	muropeptides	35-47	tumor necrosis factor	Homo sapiens	59-86
21178363-6	2010	Purified glutathione-S-transferase (GST)-p40 and -p75 fusion proteins were able to hydrolyze the muropeptides from L. casei cell walls.	muropeptides	97-109	interleukin 9	Homo sapiens	41-44
17420470-2	2007	Nod1, a member of this family, is activated by specific peptidoglycan-derived muropeptides that contain meso-diaminopimelic acid.	muropeptides	78-90	nucleotide binding oligomerization domain containing 1	Homo sapiens	0-4
20438865-4	2010	All three muropeptides induced TNF-alpha and IL-6 production by Mphi (GM-3P>GM-4P>>(GM-4P)(2)), but failed to trigger TNF-alpha, IL-6 and IL-12p70 production by immature DCs.	muropeptides	10-22	tumor necrosis factor	Homo sapiens	31-40
20438865-4	2010	All three muropeptides induced TNF-alpha and IL-6 production by Mphi (GM-3P>GM-4P>>(GM-4P)(2)), but failed to trigger TNF-alpha, IL-6 and IL-12p70 production by immature DCs.	muropeptides	10-22	interleukin 6	Homo sapiens	45-49
20438865-4	2010	All three muropeptides induced TNF-alpha and IL-6 production by Mphi (GM-3P>GM-4P>>(GM-4P)(2)), but failed to trigger TNF-alpha, IL-6 and IL-12p70 production by immature DCs.	muropeptides	10-22	interleukin 6	Homo sapiens	138-142
17705850-1	2007	BACKGROUND: NOD2, an intracellular pathogen recognition sensor, modulates innate defences to muropeptides derived from various bacterial species, including Mycobacterium tuberculosis (MTB).	muropeptides	93-105	nucleotide binding oligomerization domain containing 2	Homo sapiens	12-16
17145940-2	2007	It is shown that a number of these muropeptides can induce tumor necrosis factor alpha (TNF-alpha) gene expression without significant TNF-alpha translation.	muropeptides	35-47	tumor necrosis factor	Homo sapiens	88-97
17145940-3	2007	This translation block is lifted when the muropeptides are coincubated with lipopolysaccharide (LPS), thereby accounting for an apparently synergistic effect of the muropeptides with LPS on TNF-alpha protein production.	muropeptides	42-54	tumor necrosis factor	Homo sapiens	190-199
17145940-3	2007	This translation block is lifted when the muropeptides are coincubated with lipopolysaccharide (LPS), thereby accounting for an apparently synergistic effect of the muropeptides with LPS on TNF-alpha protein production.	muropeptides	165-177	tumor necrosis factor	Homo sapiens	190-199
16918516-1	2006	BACKGROUND: Caspase recruitment domain protein (CARD) 4 has been recently identified as an intracellular pattern recognition receptor that interacts with muropeptides found in common Gram-negative bacteria.	muropeptides	154-166	nucleotide binding oligomerization domain containing 1	Homo sapiens	12-55
17024181-4	2006	GNBP1 was able to hydrolyze Gram-positive peptidoglycan (PG), while PGRP-SA bound highly purified PG fragments (muropeptides).	muropeptides	112-124	Peptidoglycan recognition protein SA	Drosophila melanogaster	68-75
17024181-6	2006	PGRP-SA binding depended on the polymerization status of the muropeptides, pointing to constraints in the number of PGRP-SA molecules bound for signaling initiation.	muropeptides	61-73	Peptidoglycan recognition protein SA	Drosophila melanogaster	0-7
17024181-6	2006	PGRP-SA binding depended on the polymerization status of the muropeptides, pointing to constraints in the number of PGRP-SA molecules bound for signaling initiation.	muropeptides	61-73	Peptidoglycan recognition protein SA	Drosophila melanogaster	116-123
16260731-9	2005	Only additive effects of IL-32 and muropeptides were observed for TNF-alpha production.	muropeptides	35-47	tumor necrosis factor	Homo sapiens	66-75
16260731-3	2005	IL-32 synergized with the NOD1- and NOD2-specific muropeptides of peptidoglycans for the release of IL-1beta and IL-6 (a 3- to 10-fold increase).	muropeptides	50-62	interleukin 32	Homo sapiens	0-5
16222728-8	2005	Furthermore, the pattern recognition receptors Nod1 and Nod2 have been implicated in the possible induction of a synergistic effect of muropeptides with LPS.	muropeptides	135-147	nucleotide binding oligomerization domain containing 1	Homo sapiens	47-51
16260731-3	2005	IL-32 synergized with the NOD1- and NOD2-specific muropeptides of peptidoglycans for the release of IL-1beta and IL-6 (a 3- to 10-fold increase).	muropeptides	50-62	nucleotide binding oligomerization domain containing 1	Homo sapiens	26-30
16260731-3	2005	IL-32 synergized with the NOD1- and NOD2-specific muropeptides of peptidoglycans for the release of IL-1beta and IL-6 (a 3- to 10-fold increase).	muropeptides	50-62	nucleotide binding oligomerization domain containing 2	Homo sapiens	36-40
16260731-3	2005	IL-32 synergized with the NOD1- and NOD2-specific muropeptides of peptidoglycans for the release of IL-1beta and IL-6 (a 3- to 10-fold increase).	muropeptides	50-62	interleukin 1 beta	Homo sapiens	100-108
16260731-3	2005	IL-32 synergized with the NOD1- and NOD2-specific muropeptides of peptidoglycans for the release of IL-1beta and IL-6 (a 3- to 10-fold increase).	muropeptides	50-62	interleukin 6	Homo sapiens	113-117
16150702-2	2005	Nod1 has been described recently as a cytosolic receptor that detects specifically diaminopimelate-containing muropeptides from Gram-negative bacteria peptidoglycan.	muropeptides	110-122	nucleotide-binding oligomerization domain containing 1	Mus musculus	0-4
16222728-8	2005	Furthermore, the pattern recognition receptors Nod1 and Nod2 have been implicated in the possible induction of a synergistic effect of muropeptides with LPS.	muropeptides	135-147	nucleotide binding oligomerization domain containing 2	Homo sapiens	56-60
16021602-1	2005	Muropeptides are degradation products of bacterial peptidoglycan (PG) sensed by nucleotide-binding oligomerization domain 1 (NOD1) and NOD2, members of a recently discovered family of pattern recognition molecules (PRM).	muropeptides	0-12	nucleotide binding oligomerization domain containing 1	Homo sapiens	80-123
16021602-1	2005	Muropeptides are degradation products of bacterial peptidoglycan (PG) sensed by nucleotide-binding oligomerization domain 1 (NOD1) and NOD2, members of a recently discovered family of pattern recognition molecules (PRM).	muropeptides	0-12	nucleotide binding oligomerization domain containing 1	Homo sapiens	125-129
16021602-1	2005	Muropeptides are degradation products of bacterial peptidoglycan (PG) sensed by nucleotide-binding oligomerization domain 1 (NOD1) and NOD2, members of a recently discovered family of pattern recognition molecules (PRM).	muropeptides	0-12	nucleotide binding oligomerization domain containing 2	Homo sapiens	135-139
16021602-2	2005	One of these muropeptides, muramyl dipeptide (MDP) mediates cell signaling by NOD2, exerts adjuvant activity and synergizes with lipopolysaccharide (LPS) to induce pro-inflammatory responses in vitro and in vivo.	muropeptides	13-25	nucleotide binding oligomerization domain containing 2	Homo sapiens	78-82
16021603-8	2005	In contrast to cell lines, primary human peripheral blood mononuclear cells respond to NOD1 muropeptides at approximately 100-fold lower concentrations.	muropeptides	92-104	nucleotide binding oligomerization domain containing 1	Homo sapiens	87-91
7551813-10	1995	From these data, we would speculate that a probable physiological role of the muramylalanine amidase is the maintenance of adequate ratios between the biologically active muropeptides and their inactive derivatives in the organism, the amidase activity antagonizing the production of biologically active molecules by lysozyme.	muropeptides	171-183	lysozyme	Homo sapiens	317-325
15791270-5	2005	We report that in both peptidoglycans, the minimal structure needed to activate the Toll pathway is a muropeptide dimer and that the free reducing end of the N-acetyl muramic acid residues of the muropeptides is essential for activity.	muropeptides	196-208	Toll	Drosophila melanogaster	84-88
15716453-2	2005	The stable resistant mutant ZOX3 had an increased ceftizoxime MIC and a decreased affinity of its PBP2 for ceftizoxime and produced peptidoglycan in which the proportion of highly cross-linked muropeptides was reduced.	muropeptides	193-205	AT695_RS10295	Staphylococcus aureus	98-102
24762004-1	2015	Changes in the peptidoglycan (PG) structure of Salmonella enterica are detected in the presence of a sublethal concentration of sodium deoxycholate (DOC): (i) lower proportions of Braun lipoprotein (Lpp)-bound muropeptides; (ii) reduced levels of muropeptides cross-linked by L(meso)-diaminopimelyl-D(meso)-diaminopimelic acid (L-D) peptide bridges (3-3 cross-links).	muropeptides	210-222	lipoprotein	Salmonella enterica	186-197
7925310-0	1994	Bacterial cell wall recycling provides cytosolic muropeptides as effectors for beta-lactamase induction.	muropeptides	49-61	beta-lactamase	Escherichia coli	79-93
24762004-1	2015	Changes in the peptidoglycan (PG) structure of Salmonella enterica are detected in the presence of a sublethal concentration of sodium deoxycholate (DOC): (i) lower proportions of Braun lipoprotein (Lpp)-bound muropeptides; (ii) reduced levels of muropeptides cross-linked by L(meso)-diaminopimelyl-D(meso)-diaminopimelic acid (L-D) peptide bridges (3-3 cross-links).	muropeptides	210-222	lipoprotein	Salmonella enterica	199-202
34951523-4	2022	These unique muropeptides were applied for the study of human NOD2 stimulation.	muropeptides	13-25	nucleotide binding oligomerization domain containing 2	Homo sapiens	62-66
35420957-4	2022	Peptidoglycan-derived muropeptides reach the brain and alter the activity of a subset of brain neurons that express Nod2.	muropeptides	22-34	nucleotide-binding oligomerization domain containing 2	Mus musculus	116-120
33508265-10	2021	While such HDM-associated muropeptides were found to activate NOD1 signaling in epithelial cells, peptidoglycan-depleted HDM had a decreased ability to instigate asthma in vivo.	muropeptides	26-38	nucleotide-binding oligomerization domain containing 1	Mus musculus	62-66
33020220-6	2020	For instance, the pdeA pgpH mutant was defective for the synthesis of peptidoglycan muropeptides, and was susceptible to cell wall targeting antimicrobials.	muropeptides	84-96	cyclic-di-AMP phosphodiesterase PgpH	Listeria monocytogenes	23-27
35052944-3	2022	The key genes (ampD, ampE and ampG) to which the AmpC induction mechanism is linked are also involved in regulating the production of fragmented muropeptides generated during cell-wall peptidoglycan recycling.	muropeptides	145-157	beta-lactamase	Escherichia coli	49-53