PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33491580-8 2021 Molecular dynamics simulation (MDS) was performed to observe behavior and interaction of potential drug hydrazinocurcumin against target proteins ACE-2 and PAR-1. hydrazinocurcumin 104-121 angiotensin converting enzyme 2 Homo sapiens 146-151 22179587-0 2012 The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition. hydrazinocurcumin 22-39 signal transducer and activator of transcription 3 Homo sapiens 135-140 20797619-4 2010 Inhibition of the histone acetyltransferase (HAT) activity of p300 by a water-soluble, small molecule inhibitor, Hydrazinocurcumin (CTK7A), substantially reduced the xenografted oral tumor growth in mice. hydrazinocurcumin 113-130 E1A binding protein p300 Mus musculus 62-66 33491580-8 2021 Molecular dynamics simulation (MDS) was performed to observe behavior and interaction of potential drug hydrazinocurcumin against target proteins ACE-2 and PAR-1. hydrazinocurcumin 104-121 coagulation factor II thrombin receptor Homo sapiens 156-161 32559627-0 2020 Hydrazinocurcumin and 5-fluorouracil enhance apoptosis and restrain tumorigenicity of HepG2 cells via disrupting the PTEN-mediated PI3K/Akt signaling pathway. hydrazinocurcumin 0-17 phosphatase and tensin homolog Homo sapiens 117-121 32559627-0 2020 Hydrazinocurcumin and 5-fluorouracil enhance apoptosis and restrain tumorigenicity of HepG2 cells via disrupting the PTEN-mediated PI3K/Akt signaling pathway. hydrazinocurcumin 0-17 AKT serine/threonine kinase 1 Homo sapiens 136-139 32559627-6 2020 We found that HZC or 5-Fu induced apoptosis and repressed proliferation of HepG2 cells by upregulating the expression of PTEN and disrupting the PI3K/Akt signaling pathway activation. hydrazinocurcumin 14-17 phosphatase and tensin homolog Homo sapiens 121-125 32559627-6 2020 We found that HZC or 5-Fu induced apoptosis and repressed proliferation of HepG2 cells by upregulating the expression of PTEN and disrupting the PI3K/Akt signaling pathway activation. hydrazinocurcumin 14-17 AKT serine/threonine kinase 1 Homo sapiens 150-153 32559627-9 2020 Inhibition of PTEN expression activated the PI3K/Akt signaling pathway and reversed the protective effects of HZC or 5-Fu. hydrazinocurcumin 110-113 phosphatase and tensin homolog Homo sapiens 14-18 32559627-9 2020 Inhibition of PTEN expression activated the PI3K/Akt signaling pathway and reversed the protective effects of HZC or 5-Fu. hydrazinocurcumin 110-113 AKT serine/threonine kinase 1 Homo sapiens 49-52 32559627-10 2020 Thus, HZC and 5-Fu increase PTEN, which blocks the PI3K/Akt signaling pathway, ultimately inducing HepG2 cell apoptosis. hydrazinocurcumin 6-9 phosphatase and tensin homolog Homo sapiens 28-32 32559627-10 2020 Thus, HZC and 5-Fu increase PTEN, which blocks the PI3K/Akt signaling pathway, ultimately inducing HepG2 cell apoptosis. hydrazinocurcumin 6-9 AKT serine/threonine kinase 1 Homo sapiens 56-59 25985292-0 2015 Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant alpha-Synuclein. hydrazinocurcumin 0-17 synuclein alpha Homo sapiens 156-171 25985292-5 2015 curcumin pyrazole and curcumin isoxazole and their derivatives against alpha-synuclein aggregation, fibrillization and toxicity. hydrazinocurcumin 0-17 synuclein alpha Homo sapiens 71-86 25985292-6 2015 Employing biochemical, biophysical and cell based assays we discovered that curcumin pyrazole (3) and its derivative N-(3-Nitrophenylpyrazole) curcumin (15) exhibit remarkable potency in not only arresting fibrillization and disrupting preformed fibrils but also preventing formation of A11 conformation in the protein that imparts toxic effects. hydrazinocurcumin 76-93 immunoglobulin kappa variable 3D-20 Homo sapiens 287-290 32100959-0 2021 Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells through the p38 MAPK Pathway. hydrazinocurcumin 0-17 mitogen-activated protein kinase 14 Homo sapiens 82-85 32100959-11 2021 These results provide evidence that HZC exerted anti-oncogenic and pro-apoptosis effects in HCC cells through activation of the p38 MAPK pathway. hydrazinocurcumin 36-39 mitogen-activated protein kinase 14 Homo sapiens 128-131 30771374-0 2019 Activation of anti-oxidant of curcumin pyrazole derivatives through preservation of mitochondria function and Nrf2 signaling pathway. hydrazinocurcumin 30-47 NFE2 like bZIP transcription factor 2 Rattus norvegicus 110-114 29246079-0 2018 Curcumin pyrazole blocks lipopolysaccharide-induced inflammation via suppression of JNK activation in RAW 264.7 macrophages. hydrazinocurcumin 0-17 mitogen-activated protein kinase 8 Homo sapiens 84-87 27890795-3 2017 This study aimed at understanding the effectiveness of the hydrazinocurcumin, CTK7A, an inhibitor of p300 lysine/histone acetyltransferase (KAT/HAT) activity, in inducing apoptosis of gastric cancer cells (GCCs) exposed to cobalt chloride (CoCl2), a hypoxia-mimetic chemical, or 1% O2. hydrazinocurcumin 59-76 E1A binding protein p300 Homo sapiens 101-105 27890795-3 2017 This study aimed at understanding the effectiveness of the hydrazinocurcumin, CTK7A, an inhibitor of p300 lysine/histone acetyltransferase (KAT/HAT) activity, in inducing apoptosis of gastric cancer cells (GCCs) exposed to cobalt chloride (CoCl2), a hypoxia-mimetic chemical, or 1% O2. hydrazinocurcumin 59-76 thiosulfate sulfurtransferase like domain containing 1 Homo sapiens 140-143 27890795-3 2017 This study aimed at understanding the effectiveness of the hydrazinocurcumin, CTK7A, an inhibitor of p300 lysine/histone acetyltransferase (KAT/HAT) activity, in inducing apoptosis of gastric cancer cells (GCCs) exposed to cobalt chloride (CoCl2), a hypoxia-mimetic chemical, or 1% O2. hydrazinocurcumin 59-76 transmembrane serine protease 11D Homo sapiens 144-147