PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19474456-6	2009	Protection against lipid peroxidation of L-FABP after binding with palmitate or alpha-bromo-palmitate by the AAPH or AMVN free radical generators indicated that ligand binding can partially block antioxidant activity.	radical	127-134	fatty acid binding protein 1	Rattus norvegicus	41-47
19660198-8	2010	Both N-methyl-D-aspartic acid (NMDA) receptor antagonist (ketamine) and oxygen free radical scavenger (alpha-tocopherol) decreased AMPK activity as well as the content of GLUT4 in the plasma membrane following cerebral ischemia.	radical	84-91	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	131-135
19660198-8	2010	Both N-methyl-D-aspartic acid (NMDA) receptor antagonist (ketamine) and oxygen free radical scavenger (alpha-tocopherol) decreased AMPK activity as well as the content of GLUT4 in the plasma membrane following cerebral ischemia.	radical	84-91	solute carrier family 2 member 4	Rattus norvegicus	171-176
20230191-1	2010	An investigation into the post-translational activation of cDNA-expressed human phenylalanine 4-monooxygenase and human hepatic cytosolic fraction phenylalanine 4-monooxygenase activity with respect to both endobiotic metabolism and xenobiotic metabolism revealed that the reactive oxygen species (hydrogen peroxide and hydroxyl radical) and reactive nitrogen species (nitric oxide and peroxynitrite) could elicit the post-translational activation of the enzyme with respect to both of these biotransformation reactions.	radical	329-336	phenylalanine hydroxylase	Homo sapiens	80-109
20230191-1	2010	An investigation into the post-translational activation of cDNA-expressed human phenylalanine 4-monooxygenase and human hepatic cytosolic fraction phenylalanine 4-monooxygenase activity with respect to both endobiotic metabolism and xenobiotic metabolism revealed that the reactive oxygen species (hydrogen peroxide and hydroxyl radical) and reactive nitrogen species (nitric oxide and peroxynitrite) could elicit the post-translational activation of the enzyme with respect to both of these biotransformation reactions.	radical	329-336	phenylalanine hydroxylase	Homo sapiens	147-176
19433337-1	2009	Prostaglandin H synthase isoforms 1 and -2 (PGHS-1 and -2) react with peroxide to form a radical on Tyr385 that initiates the cyclooxygenase catalysis.	radical	89-96	prostaglandin-endoperoxide synthase 1	Homo sapiens	44-57
19754085-6	2009	Effects of metal cations on the UV-vis absorption spectra of the alpha-Toc* (and ArO*) radical were negligible in methanol solution, suggesting that the complex formation between the alpha-Toc* (and ArO*) radical molecule and metal cations is hindered by the hydrogen bond between radical and methanol molecules.	radical	87-94	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	81-85
19754085-6	2009	Effects of metal cations on the UV-vis absorption spectra of the alpha-Toc* (and ArO*) radical were negligible in methanol solution, suggesting that the complex formation between the alpha-Toc* (and ArO*) radical molecule and metal cations is hindered by the hydrogen bond between radical and methanol molecules.	radical	87-94	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	199-203
18342430-4	2008	Radical treatment was initiated in the event of biochemical progression (PSA velocity > 1 ng/ml/yr) or histological progression (primary Gleason grade >or= 4, or %pbc > 50%).	radical	0-7	aminopeptidase puromycin sensitive	Homo sapiens	73-76
18620046-8	2008	Interestingly, inducible nitric oxide synthase (iNOS) (apparently uncoupled) was identified as the major source of radical generation.	radical	115-122	nitric oxide synthase 2	Rattus norvegicus	15-46
18620046-8	2008	Interestingly, inducible nitric oxide synthase (iNOS) (apparently uncoupled) was identified as the major source of radical generation.	radical	115-122	nitric oxide synthase 2	Rattus norvegicus	48-52
18502093-0	2008	Radical-scavenging abilities and antioxidant properties of theaflavins and their gallate esters in H2O2-mediated oxidative damage system in the HPF-1 cells.	radical	0-7	histone PARylation factor 1	Homo sapiens	144-149
16843823-4	2006	We use a novel antiserum to 5,5-dimethyl-1-pyrroline N-oxide (DMPO) to detect radical-derived DMPO spin-trapped TPO.	radical	78-85	thyroid peroxidase	Homo sapiens	112-115
17945354-7	2007	Results obtained with the global activator phorbol myristate acetate, as well as with fMLF in TNF alpha-primed leukocytes, suggested that the deficiency of oxygen radical production in patients with severe GBS was the result of a specific deficiency of radical production in response to FPR/FPRL1 ligands rather than an inherent deficiency of NADPH oxidase function.	radical	163-170	tumor necrosis factor	Homo sapiens	94-103
17505560-6	2007	RESULTS: PCA and PLS analysis revealed that high values of MMP-9 and low values of ICAM-1 were associated with high radical production whereas MCP-1 and oxLDL were not correlated to radical production.	radical	116-123	matrix metallopeptidase 9	Homo sapiens	59-64
17505560-6	2007	RESULTS: PCA and PLS analysis revealed that high values of MMP-9 and low values of ICAM-1 were associated with high radical production whereas MCP-1 and oxLDL were not correlated to radical production.	radical	116-123	intercellular adhesion molecule 1	Homo sapiens	83-89
17388277-1	2007	The interaction of NO3 free radical and N2O5 with laboratory flame soot was investigated in a Knudsen flow reactor at T = 298 K equipped with beam-sampling mass spectrometry and in situ REMPI detection of NO2 and NO.	radical	28-35	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
16599641-0	2006	Radical-mediated opening of 2,3-epoxy alcohols using Cp2TiCl: stereoselective construction of quaternary chiral centers.	radical	0-7	ceruloplasmin	Homo sapiens	53-56
16331683-3	2006	Data have indicated that neither SMAD nor c-Jun NH2 Terminal Kinase (JNK) activations are altered by EGF, which clearly interferes with events directly related to the radical oxygen species (ROS) production, impairing oxidative stress, p38 MAP kinase activation, and cell death.	radical	167-174	epidermal growth factor like 1	Rattus norvegicus	101-104
16599641-1	2006	Radical-mediated opening of chiral 2,3-epoxy alcohols regioselectively at the 2-position using Cp2TiCl and trapping the intermediate radical with methyl acrylate and acrylonitrile led to the stereoselective formation of tetrasubstituted chiral centers.	radical	0-7	ceruloplasmin	Homo sapiens	95-98
16407283-9	2006	The findings raise the possibility of a positive feedback loop in which NF-kappaB activation by oxidative stress leads to further radical production via NADPH oxidase.	radical	130-137	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	72-81
16286808-6	2006	In cell-free systems using H(2)O(2)/HOCl(-) and SIN-1 as radical producers, a significant scavenging activity of thymol was present already at 0.08 and 0.68 microg/ml respectively, and these are very low concentrations.	radical	57-64	MAPK associated protein 1	Homo sapiens	48-53
16401082-0	2006	Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes.	radical	0-7	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	88-103
16084485-10	2005	These findings support the proposal that UCP3 attenuates endogenous radical production by the mitochondrial electron transport chain at high protonmotive force.	radical	68-75	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	41-45
16268602-8	2005	Radical 3 also reacted by fragmentation of methoxide in Lewis-acid-catalyzed heterolysis reactions; ZnBr2, Sc(OTf)3, and BF3 were found to be efficient catalysts.	radical	0-7	POU class 5 homeobox 1	Homo sapiens	107-115
16061872-2	2005	AN-207, consisting of [D-Lys(6)] LHRH linked to a cytotoxic radical, 2-pyrrolinodoxorubicin (AN-201), binds with high affinity to LHRH receptors and can be targeted to tumors expressing these receptors.	radical	60-67	gonadotropin releasing hormone 1	Homo sapiens	33-37
16061872-2	2005	AN-207, consisting of [D-Lys(6)] LHRH linked to a cytotoxic radical, 2-pyrrolinodoxorubicin (AN-201), binds with high affinity to LHRH receptors and can be targeted to tumors expressing these receptors.	radical	60-67	gonadotropin releasing hormone 1	Homo sapiens	130-134
15728783-9	2005	Both allantoin, a marker of oxygen free radical generation, and reactive oxygen species increased significantly after EPO or NESP treatment compared with control.	radical	40-47	GNAS complex locus	Homo sapiens	125-129
23045123-1	2005	NADH cytochrome b(5) reductase (b(5)R; EC 1.6.2.2; Diaphorase I; NADH: ferricytochrome b(5) oxidoreductase) is an FAD-containing protein, which, along with the hemoprotein cytochrome b(5) (cyt b(5)), mediates electron transfer from NADH to fatty acid desaturases, P450 oxidases, methemoglobin, and ascorbyl free radical.	radical	312-319	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	264-268
23045123-1	2005	NADH cytochrome b(5) reductase (b(5)R; EC 1.6.2.2; Diaphorase I; NADH: ferricytochrome b(5) oxidoreductase) is an FAD-containing protein, which, along with the hemoprotein cytochrome b(5) (cyt b(5)), mediates electron transfer from NADH to fatty acid desaturases, P450 oxidases, methemoglobin, and ascorbyl free radical.	radical	312-319	hemoglobin subunit gamma 2	Homo sapiens	279-292
23045123-1	2005	NADH cytochrome b(5) reductase (b(5)R; EC 1.6.2.2; Diaphorase I; NADH: ferricytochrome b(5) oxidoreductase) is an FAD-containing protein, which, along with the hemoprotein cytochrome b(5) (cyt b(5)), mediates electron transfer from NADH to fatty acid desaturases, P450 oxidases, methemoglobin, and ascorbyl free radical.	radical	312-319	cytochrome b5 type A	Homo sapiens	5-20
23045123-1	2005	NADH cytochrome b(5) reductase (b(5)R; EC 1.6.2.2; Diaphorase I; NADH: ferricytochrome b(5) oxidoreductase) is an FAD-containing protein, which, along with the hemoprotein cytochrome b(5) (cyt b(5)), mediates electron transfer from NADH to fatty acid desaturases, P450 oxidases, methemoglobin, and ascorbyl free radical.	radical	312-319	cytochrome b5 type A	Homo sapiens	76-91
15527282-11	2004	This study demonstrates the suitability of the AMPO nitrone for use as a spin trap to study radical production in aqueous systems.	radical	92-99	spindlin 1	Homo sapiens	73-77
23045123-1	2005	NADH cytochrome b(5) reductase (b(5)R; EC 1.6.2.2; Diaphorase I; NADH: ferricytochrome b(5) oxidoreductase) is an FAD-containing protein, which, along with the hemoprotein cytochrome b(5) (cyt b(5)), mediates electron transfer from NADH to fatty acid desaturases, P450 oxidases, methemoglobin, and ascorbyl free radical.	radical	312-319	cytochrome b5 type A	Homo sapiens	189-197
11421701-1	2001	Radical salts of bis(ethylenethia)tetrathiafulvalene (BET-TTF) with the octahedral anions hexacyanoferrate(III) and nitroprusside.	radical	0-7	delta/notch like EGF repeat containing	Homo sapiens	54-57
15208394-2	2004	Here, we show that the Arabidopsis mutant radical-induced cell death1 (rcd1), although hypersensitive to apoplastic superoxide and ozone, is more resistant to chloroplastic superoxide formation, exhibits reduced sensitivity to abscisic acid, ethylene, and methyl jasmonate, and has altered expression of several hormonally regulated genes.	radical	42-49	WWE protein-protein interaction domain protein family	Arabidopsis thaliana	71-75
14718647-7	2004	When cells were prelabeled with N-acetyl-cysteine (NAC), a substrate for glutathione synthesis, and catalase (CAT), the oxygen free radical scavenger, a significant reduction in cytogenetic damage was observed.	radical	132-139	catalase	Homo sapiens	100-108
14718647-7	2004	When cells were prelabeled with N-acetyl-cysteine (NAC), a substrate for glutathione synthesis, and catalase (CAT), the oxygen free radical scavenger, a significant reduction in cytogenetic damage was observed.	radical	132-139	catalase	Homo sapiens	110-113
14500751-10	2003	Tetrahydrobiopterin-derived radical species formed by reaction with reactive nitrogen species may account for inhibition of TH via mechanisms that do not involve tyrosine nitration.	radical	28-35	tyrosine hydroxylase	Homo sapiens	124-126
12575998-4	2003	In addition, hydroxyl-radical probings of RRF on the ribosome are not in agreement with the simple idea that RRF mimics tRNA in the ribosome A-site.	radical	22-29	mitochondrial ribosome recycling factor	Homo sapiens	42-45
12564902-5	2003	The reactions of naphthalene and the alkylnaphthalenes with NO3 radicals proceed by initial addition of the radical to form an aromatic-NO3 adduct (with rate constant k(a)) which either decomposes back to reactants (with rate constant kb) or reacts with NO2 to form products (with rate constant k(c).	radical	64-71	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
12564902-5	2003	The reactions of naphthalene and the alkylnaphthalenes with NO3 radicals proceed by initial addition of the radical to form an aromatic-NO3 adduct (with rate constant k(a)) which either decomposes back to reactants (with rate constant kb) or reacts with NO2 to form products (with rate constant k(c).	radical	64-71	NBL1, DAN family BMP antagonist	Homo sapiens	136-139
12040026-5	2002	Of the other two sequenced amplicons, one encoded a partial sequence for mitochondrial manganese-dependent superoxide dismutase (SOD2), an enzyme that is likely to protect adrenocortical cells from the cytotoxic effects of radical oxygen species generated during steroid biosynthesis.	radical	223-230	superoxide dismutase 2, mitochondrial	Bos taurus	129-133
15292117-12	2004	Vitamin E enhanced the therapeutic effect of the PDE5 inhibitor in this study, supporting the potential use of oxygen free radical scavengers in salvaging erectile function in diabetic patients.	radical	123-130	phosphodiesterase 5A	Homo sapiens	49-53
15081107-5	2004	Moreover, the LEW/Mol strain had higher production of radical oxygen species in peripheral blood leukocytes, a phenomenon most likely regulated by the polymorphisms in the Ncf1 gene.	radical	54-61	neutrophil cytosolic factor 1	Rattus norvegicus	172-176
14657410-2	2004	A complementation test revealed that the obtained mutant was allelic to the ozone-sensitive radical-induced cell death1-1 (rcd1-1).	radical	92-99	WWE protein-protein interaction domain protein family	Arabidopsis thaliana	123-129
12694301-5	2003	Radical (i.e., superoxide) (O2-) formation in response to oxLDL is associated with p53, as well as HIF-1 alpha accumulation in human macrophages, a process that is antagonized by NO.	radical	0-7	tumor protein p53	Homo sapiens	83-86
12694301-5	2003	Radical (i.e., superoxide) (O2-) formation in response to oxLDL is associated with p53, as well as HIF-1 alpha accumulation in human macrophages, a process that is antagonized by NO.	radical	0-7	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-110
12682616-15	2003	Radical-exposed IgG is able to bind rheumatoid factor and results in the generation of C3alpha.	radical	0-7	complement C3	Homo sapiens	87-94
12393560-8	2002	In addition, z-VAD-fmk amplifies the differentiation-associated production of radical oxygen species in both phorbol ester-differentiated U937 cells and M-CSF-treated monocytes, shifting the differentiation process to nonapoptotic cell death.	radical	78-85	colony stimulating factor 1	Homo sapiens	153-158
12388163-6	2002	Pretreatment with oxygen free radical scavengers, superoxide dismutase (50,000 U/kg) and catalase (90,000 U/kg), also attenuated these PGF(2 alpha)-induced alterations.	radical	30-37	catalase	Rattus norvegicus	72-97
12482241-1	2002	Although myoglobin protein radicals are thought important intermediates in peroxide-induced toxicity, the site of spin trapping of this radical in equine myoglobin using the trap 3,5-dibromo-4-nitrosobenzene sulfonate (DBNBS) is unclear.	radical	27-34	myoglobin	Equus caballus	9-18
11421701-1	2001	Radical salts of bis(ethylenethia)tetrathiafulvalene (BET-TTF) with the octahedral anions hexacyanoferrate(III) and nitroprusside.	radical	0-7	ras homolog family member H	Homo sapiens	58-61
9922219-8	1999	Superoxide (SO) radical generation was deficient in macrophages from SP-A (-/-) mice.	radical	16-23	surfactant associated protein A1	Mus musculus	69-73
10821663-0	2000	Reaction of bovine cytochrome c oxidase with hydrogen peroxide produces a tryptophan cation radical and a porphyrin cation radical.	radical	92-99	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	19-39
10722691-3	2000	Room temperature continuous wave EPR measurements at X-band of whole cells of menA and menB interruption mutants show a transient reduction and oxidation of an organic radical with a g-value and anisotropy characteristic of a quinone.	radical	168-175	ENAH actin regulator	Homo sapiens	78-82
11455199-5	2001	Similar inhibition of glutamate decarboxylase and cysteine sulfinic acid decarboxylase by two different radical-containing compounds (O2 and NO) is consistent with the notion that these reactions proceed via radical mechanisms.	radical	104-111	glutamate-ammonia ligase	Homo sapiens	22-45
10380898-4	1999	Radical production and release were inhibited by all agonists tested [i.e. the protein kinase C-activating phorbol ester phobol myristate acetate; the receptor-specific agonist N-formyl-methionyl-leucyl-phenylalanine (fMLP); and serum-opsonized yeast particles] in the presence of B220.	radical	0-7	protein tyrosine phosphatase receptor type C	Homo sapiens	281-285
10215584-5	1999	The results obtained are consistent with the hypothesis that radical-induced oxidation of LDL"s lipids by HOCl is a secondary reaction, with most HOCl consumed via rapid, non-radical reaction with apolipoprotein B-100.	radical	61-68	apolipoprotein B	Homo sapiens	197-217
9507996-0	1998	Radical-induced lipoprotein and plasma lipid oxidation in normal and apolipoprotein E gene knockout (apoE-/-) mice: apoE-/- mouse as a model for testing the role of tocopherol-mediated peroxidation in atherogenesis.	radical	0-7	apolipoprotein E	Mus musculus	101-109
9525912-2	1998	Reduction of ascorbate free radical by this system is comprised of two activities, one of them dependent on coenzyme Q6 (CoQ6).	radical	28-35	putative N,N-dimethylaniline monooxygenase COQ6	Saccharomyces cerevisiae S288C	108-119
9617758-0	1998	Radical releasing properties of nitric oxide donors GEA 3162, SIN-1 and S-nitroso-N-acetylpenicillamine.	radical	0-7	MAPK associated protein 1	Homo sapiens	62-67
9790513-2	1998	Along with redox cycling induced by a reductase, a similar process is known to occur via electron transfer from ascorbate (AscH-) to Q with formation of a semiquinone radical (Q.-): (1) Q + AscH- (k1)--> Q.- + Asc.- + H+ (2) Q.- + O2 --> Q + O2.-.	radical	167-174	PYD and CARD domain containing	Homo sapiens	123-126
7503550-0	1995	Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivatives.	radical	113-120	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	27-39
8896750-2	1996	radical (chemically generated by Fenton"s reaction) of partially purified rat liver PKC has been evaluated in this work.	radical	0-7	protein kinase C, gamma	Rattus norvegicus	84-87
9544795-7	1998	Radical (NO./O2-) cogeneration abrogated DNA fragmentation, suppressed caspase activation and lowered p53 accumulation, thereby promoting cell survival of mesangial cells.	radical	0-7	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	102-105
7783053-5	1995	Radical production was measured by a cytochrome C reduction assay.	radical	0-7	cytochrome c, somatic	Homo sapiens	37-49
7545633-6	1995	The oxygen free radical scavengers, dimethylsulphoxide (0.2-0.4 M) and glutathione (2 x 10(-6)-10(-5) M) block the TNF alpha-mediated cytolysis of target cells in the absence of protein synthesis inhibitors, but not in the presence of EM or ACT-D.	radical	16-23	tumor necrosis factor	Mus musculus	115-124
7646435-12	1995	Three inhibitors of this radical-generating signalling pathway, including an arachidonate analogue (5,8,11,14-eicosatetraynoic acid), could protect cells against TNF alpha.	radical	25-32	tumor necrosis factor	Mus musculus	162-171
7633144-1	1995	Xanthine oxidase may contribute to oxygen free radical formation during reoxygenation after hypoxia, but in humans the enzyme is present in substantial amounts only in the liver and intestine.	radical	47-54	xanthine dehydrogenase	Sus scrofa	0-16
7648404-11	1995	However, DHOdehase should be considered as a source of radical oxygen species under pathophysiological conditions.	radical	55-62	dihydroorotate dehydrogenase (quinone)	Rattus norvegicus	9-18
8379932-4	1993	In contrast, with an increasing degree of radical-mediated oxidation of labelled HDL3, [3H]cholesteryl linoleate ([3H]Ch18:2) was taken up at an increasingly greater rate than were 125I-apoproteins.	radical	42-49	HDL3	Homo sapiens	81-85
8081209-0	1994	TNF-alpha effect on oxygen free radical scavenging and generating enzymes in rat liver.	radical	32-39	tumor necrosis factor	Rattus norvegicus	0-9
8075245-5	1994	Superoxide dismutase as well as KCN suppressed the radical production, thus being suggestive of the generation of superoxide radicals in the bc1 complex, while the mechanism of O2- production is the same as was suggested for isolated mitochondria.	radical	51-58	brain cytoplasmic RNA 1	Rattus norvegicus	141-144
2176782-2	1990	The influence of dihydralazine and exogenous superoxide dismutase (SOD) on the radical generation was observed.	radical	79-86	superoxide dismutase 1	Homo sapiens	45-65
8389205-8	1993	The lipophilic nitroso spin trap, 2-methyl-2-nitroso propane, which traps a lipid-derived radical, inhibited the low-density lipoprotein modification as did the water-soluble nitroso analog, 2-hydroxymethyl-2-nitroso propane.	radical	90-97	spindlin 1	Homo sapiens	23-27
1588932-4	1992	Vit E supplementation to exercising animals completely abolished the radical production.	radical	69-76	vitrin	Rattus norvegicus	0-3
1311586-3	1992	The steady state concentration of this radical was not decreased by CO or SKF 525-A (two inhibitors of cytochrome P450), but was decreased by NADP+ (10 mM) or p-chloromercuribenzoate (0.47 mM) (two inhibitors of NADPH-cytochrome P450 reductase activity).	radical	39-46	cytochrome p450 oxidoreductase	Rattus norvegicus	212-243
1352762-4	1992	The results suggest that increases in glutamate, perhaps due to the decreased activities of glutamine synthetase, are correlated with increased oxygen free radical formation during an ischemia/reperfusion insult to the heart.	radical	156-163	glutamate-ammonia ligase	Homo sapiens	92-112
1657966-3	1991	The addition of catalase and superoxide dismutase resulted in a 28.5 and 24% decrease in radical production, respectively.	radical	89-96	catalase	Rattus norvegicus	16-24
8397147-0	1993	Radical-induced damage to bovine serum albumin: role of the cysteine residue.	radical	0-7	albumin	Homo sapiens	33-46
1317326-0	1992	tert-Butyl hydroperoxide-induced radical production in rat liver mitochondria.	radical	33-40	telomerase reverse transcriptase	Rattus norvegicus	0-4
1915737-4	1991	Our hypothesis is that abnormal iron handling by the transferrin receptor may contribute to the formation of free radical species which catalyze the lipid peroxidation of nigral cell membranes.	radical	114-121	transferrin receptor	Mus musculus	53-73
2164003-2	1990	Radical production from 3,5-bis(ethoxycarbonyl)-4-ethyl-2,6-dimethyl-1,4- dihydropyridine (DDEP) in rat liver microsomes has been attributed to one-electron oxidation via cytochrome P-450 followed by extrusion of an ethyl radical.	radical	0-7	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	171-187
2182022-6	1990	It is likely that the generation of the radical proceeds via a ferryl intermediate, as in the proposed mechanisms for cytochrome P-450 and the peroxidases.	radical	40-47	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	118-134
2176782-2	1990	The influence of dihydralazine and exogenous superoxide dismutase (SOD) on the radical generation was observed.	radical	79-86	superoxide dismutase 1	Homo sapiens	67-70
2176782-3	1990	In the presence of dihydralazine the radical production increases distinctly; the higher hydroxyl radical production is observed for the dihydralazine-SOD containing system which is explained by the partial decomposition of the enzyme in the presence of dihydralazine.	radical	37-44	superoxide dismutase 1	Homo sapiens	151-154
35551184-4	2022	For the Mn2+ analog, light irradiation changes the spin topology from a single Mn2+ ion to a radical-Mn2+ single chain, further inducing magnetic bistability with a remarkably wide thermal hysteresis of 177 K. Structural analysis of light irradiated crystals at 300 and 50 K reveals that the rotation of the anthracene rings changes the Mn1-O2-C8 angle and coordination geometries of the Mn2+ center, resulting in magnetic bistability with this wide thermal hysteresis.	radical	93-100	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	337-340
29332244-3	2018	Although the catalytic subunit of Elongator is Elp3, which contains a radical S-adenosyl-L-methionine (SAM) domain and a putative histone acetyltransferase domain, the Elp4/5/6 subcomplex also possesses ATP-modulated tRNA binding activity.	radical	70-77	elongator acetyltransferase complex subunit 3	Homo sapiens	47-51
34154323-1	2021	All radical S-adenosylmethionine (radical-SAM) enzymes, including the noncanonical radical-SAM enzyme diphthamide biosynthetic enzyme Dph1-Dph2, require at least one (4Fe-4S)(Cys)3 cluster for activity.	radical	4-11	2-(3-amino-3-carboxypropyl)histidine synthase	Saccharomyces cerevisiae S288C	134-138
34154323-1	2021	All radical S-adenosylmethionine (radical-SAM) enzymes, including the noncanonical radical-SAM enzyme diphthamide biosynthetic enzyme Dph1-Dph2, require at least one (4Fe-4S)(Cys)3 cluster for activity.	radical	4-11	2-(3-amino-3-carboxypropyl)histidine synthase	Saccharomyces cerevisiae S288C	139-143
2548593-2	1989	Spectroscopic evidence for the radical-mediated metabolism of VP-16, VP-16 catechol, and VP-16 quinone during enzymatic oxidation and autoxidation has been obtained.	radical	31-38	host cell factor C1	Homo sapiens	62-67
2637941-2	1989	The free radical scavengers superoxide dismutase (SOD) and catalase (CAT) were used as biologic probes to detect free radical activity, while Ca2+ uptake by sarcoplasmic reticulum (SR) was used to measure subcellular muscle function.	radical	9-16	catalase	Rattus norvegicus	59-67
2637941-2	1989	The free radical scavengers superoxide dismutase (SOD) and catalase (CAT) were used as biologic probes to detect free radical activity, while Ca2+ uptake by sarcoplasmic reticulum (SR) was used to measure subcellular muscle function.	radical	9-16	catalase	Rattus norvegicus	69-72
2548593-2	1989	Spectroscopic evidence for the radical-mediated metabolism of VP-16, VP-16 catechol, and VP-16 quinone during enzymatic oxidation and autoxidation has been obtained.	radical	31-38	host cell factor C1	Homo sapiens	69-74
2548593-2	1989	Spectroscopic evidence for the radical-mediated metabolism of VP-16, VP-16 catechol, and VP-16 quinone during enzymatic oxidation and autoxidation has been obtained.	radical	31-38	host cell factor C1	Homo sapiens	69-74
3277899-3	1988	Recent evidence demonstrates that free radical scavenging agents such as superoxide dismutase (SOD) + catalase, N-2-mercaptopropionylglycine, and allopurinol, administered prior to coronary artery occlusion, significantly enhance recovery of regional contractile function of the stunned, previously ischemic tissue.	radical	39-46	catalase	Homo sapiens	102-110
2680378-0	1989	Radical intermediates in the cytochrome P-450-catalyzed oxidation of aliphatic hydrocarbons.	radical	0-7	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	29-45
2853215-7	1988	radical rapidly reacts with oxygen to give NAD+ and superoxide O2- anion radical which, in turn, reduces the second iron(III) cytochrome c molecule.	radical	0-7	cytochrome c, somatic	Homo sapiens	126-138
2854994-0	1988	Radical intermediates in the catalytic cycles of cytochrome P-450.	radical	0-7	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	49-65
2855421-6	1988	In fact, neutrophil release of lactoferrin and myeloperoxidase appears to limit formation of this radical.	radical	98-105	myeloperoxidase	Homo sapiens	47-62
3039940-3	1987	The radical adducts can then be detected by electron spin resonance spectroscopy to determine the intensity of radical production (i.e., number of radicals which were trapped), and, in most cases, identify the nature of the radical that was produced.	radical	4-11	spindlin 1	Homo sapiens	53-57
3034940-1	1987	Radical species were detected in the incubation mixtures of some retinoids (retinoic acid, retinal, retinol and retinyl acetate) by using the spin-trapping technique.	radical	0-7	spindlin 1	Homo sapiens	142-146
6309256-4	1983	Cytochrome P-450 substrates (aminopyrine) protect the enzyme against the radical-induced inactivation.	radical	73-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16
2419931-14	1985	radical is a major damaging agent in the inflamed rheumatoid joint and that its formation is facilitated by the release of iron from transferrin, which can be achieved at the low pH present in the micro-environment created by adherent activated phagocytic cells.	radical	0-7	transferrin	Homo sapiens	133-144
6319311-5	1984	The primary oxidation product is an O5"-situated alkoxy radical RCH2O which shows inequivalent beta-proton couplings of about 100 G and 35 G together with a highly anisotropic g-tensor.	radical	56-63	karyopherin subunit alpha 1	Homo sapiens	64-68
6292686-2	1982	The triarylmethane dye, gentian violet, is shown to undergo a one-electron reduction by the cytochrome P-450 monooxygenase system to produce a carbon-centered free radical as demonstrated by direct electron spin resonance techniques.	radical	164-171	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	92-122
6301163-6	1982	Administration of ethanol or benzene to rabbits, compounds known to be oxygenated by the hydroxyl radical-dependent mechanism, resulted in induction of a species of cytochrome P-450 effective in the radical-dependent metabolism of both chemicals.	radical	98-105	cytochrome P-450	Oryctolagus cuniculus	165-181
6278469-3	1981	Use of the spin traps N-tert-butyl-alpha-4-pyridylnitrone-1-oxide and 2-methyl-2-nitroso-1-propanol have allowed us to determine that lipid peroxyl radicals are the predominant "lipid-type" radical found in peroxidizing microsomes under aerobic conditions.	radical	148-155	spindlin 1	Rattus norvegicus	11-15
32232843-0	2020	ddhCTP produced by the radical-SAM activity of RSAD2 (viperin) inhibits the NAD+ -dependent activity of enzymes to modulate metabolism.	radical	23-30	radical S-adenosyl methionine domain containing 2	Homo sapiens	47-52
6260478-0	1981	Radical production from the interaction of ozone and PUFA as demonstrated by electron spin resonance spin-trapping techniques.	radical	0-7	pumilio RNA binding family member 3	Homo sapiens	53-57
33566589-7	2021	The introduction of gas-liquid interface(s) and the resultant elevated temperature inside the PVG reactor likely facilitated the generation of radicals, the subsequent radical-based reactions, and the separation/transport/detection of volatile species of elements.	radical	143-150	gastrin	Homo sapiens	20-23
32232843-0	2020	ddhCTP produced by the radical-SAM activity of RSAD2 (viperin) inhibits the NAD+ -dependent activity of enzymes to modulate metabolism.	radical	23-30	radical S-adenosyl methionine domain containing 2	Homo sapiens	54-61
31245805-1	2019	A new radical-mediated intramolecular arene C(sp2)-H amidation of 3-phenylpropanamides or [1,1"-biphenyl]-2-carboxamides was developed to prepare a series of 3,4-dihydro-2(1H)-quinolinone and phenanthridone derivatives in moderate to excellent yields (33-94%).	radical	6-13	Sp2 transcription factor	Homo sapiens	44-49
31139371-8	2019	The free radical-scavenging activity (DPPH-), ferric reducing antioxidant power (FRAP), and beta-carotene-linoleic acid assays revealed the great antioxidant potential of the jam prepared from grape peel extract, which exhibited significant levels of radical-neutralizing activity, especially as determined by the DPPH method with EC50 values ranging from 2.3 +- 0.1 to 3.9 +- 0.1 microg/ml.	radical	9-16	F11 receptor	Homo sapiens	175-178
30609764-7	2019	Procyanidin C1 possessed a strong 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and inhibited glutamate-induced accumulation of intracellular reactive oxygen species and protein carbonylation.	radical	71-78	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	0-14
30689394-0	2019	Radical Promoted C(sp2)-S Formation and C(sp3)-S Bond Cleavage: Access to 2-Substituted Thiochromones.	radical	0-7	Sp2 transcription factor	Homo sapiens	17-22
30554969-4	2019	They were able to reduce DPPH radical with IC50 values ranging from 5.08 to 19.20 microg mL-1, and some of them also reduced ABTS+ radical and TPTZ-Fe3+ complex in ABTS+ and FRAP assays, respectively.	radical	30-37	mechanistic target of rapamycin kinase	Homo sapiens	174-178
29365267-3	2018	We conclude that the formation yield of NO3 , just after the 7 ps electron pulse, is due to the direct effect and to the ultrafast electron transfer reaction between NO3- and the water cation radical, H2O +.	radical	192-199	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
29724254-0	2018	Radical containing combustion derived particulate matter enhance pulmonary Th17 inflammation via the aryl hydrocarbon receptor.	radical	0-7	aryl-hydrocarbon receptor	Mus musculus	101-126
29417107-1	2018	Formation of the key general radical chain carriers,  OH and HO2 , during pulsed-photolytic  Cl-initiated oxidation of tetrahydropyran and cyclohexane are measured with time-resolved infrared absorption in a temperature-controlled Herriott multipass cell in the temperature range of 500-750 K at 20 Torr.	radical	29-36	heme oxygenase 2	Homo sapiens	61-64
28971668-0	2017	Radical-Mediated Spin-Transfer on Gold Nanoclusters Driven an Unexpected Luminescence for Protein Discrimination.	radical	0-7	spindlin 1	Homo sapiens	17-21
28952741-1	2017	Radical cation salts composed of a bis(ethylenedithio)tetrathiafulvalene (ET) donor with homo-/heterosubstituted Cl/CN anilic acids as purely organic molecular conducting materials formulated as [BEDT-TTF]2[HClCNAn] (1) and [BEDT-TTF][HCl2An] (2) have been prepared by electrocrystallization.	radical	0-7	ras homolog family member H	Homo sapiens	201-204
28952741-1	2017	Radical cation salts composed of a bis(ethylenedithio)tetrathiafulvalene (ET) donor with homo-/heterosubstituted Cl/CN anilic acids as purely organic molecular conducting materials formulated as [BEDT-TTF]2[HClCNAn] (1) and [BEDT-TTF][HCl2An] (2) have been prepared by electrocrystallization.	radical	0-7	ras homolog family member H	Homo sapiens	230-233
28300234-1	2017	With acetone as the solvent, solvent-free neutral radical crystals of CoIII(tmp)(CN)2 are obtained, whereas solvent-inclusive crystals of CoIII(tmp)(CN)2 2CH3CN are obtained with CH3CN as the solvent.	radical	50-57	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	70-75
28955770-9	2017	Furthermore, lactate dehydrogenase (LDH) assay and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay showed that PTZ-induced addicsin translocation was accompanied by a decrease of radical-scavenging activity and an increase of cytotoxicity in a PTZ dose-dependent manner.	radical	88-95	ADP-ribosylation factor-like 6 interacting protein 5	Mus musculus	137-145
24501102-3	2014	Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule.	radical	67-74	paraoxonase 1	Homo sapiens	0-13
26464622-8	2015	CONCLUSION: MSP and its receptor RON are involved in the smoke-induced airway inflammation in rats via promoting AM to release inflammatory cytokines and inducing the increase of oxygen free radical.	radical	191-198	macrophage stimulating 1 receptor	Rattus norvegicus	33-36
25635618-1	2015	Radical-initiated addition of CCl4, Cl3CBr, PhSH, and (TMS)3SiH to (bisisopropyl)silylenedioxy-tethered bis-methacrylate derivatives gives the corresponding eight-membered ring cyclic adducts stereoselectively.	radical	0-7	C-C motif chemokine ligand 4	Homo sapiens	30-34
28082736-3	2017	Here we describe a radical-mediated, directing-group-free regioselective 1,5-hydrogen transfer of unactivated Csp3-H bonds followed by a second Csp2-H functionalization to produce, with exquisite stereoselectivity, a variety of elaborated fused ketones.	radical	19-26	regulator of calcineurin 2	Homo sapiens	144-148
28891617-7	2016	Among the chromatographic peaks, S1, S2, S27 and S33were positively related to scavenge DPPH free radical and ABTS free radical activity, and S32 was positively related to scavenge DPPH free radical and restore Fe3+ activity.	radical	98-105	ribosomal protein S27	Homo sapiens	41-44
26387554-3	2015	Ru1-Ru3 exhibited red luminescence between 670-710 nm and functioned as photo-sensitizers (PSs) by generating both singlet oxygen and radical ions.	radical	134-141	Scm like with four mbt domains 1	Homo sapiens	0-3
25964988-5	2015	These Mn(IV)(O)(pi-radical-cation) derivatives exhibit dramatically inhibited rates of OAT with the PAr3 substrates (k = 8.5(2) x 10(-3) - 8.7 M(-1) s(-1)), contrasting the previously observed rate increase of H-atom transfer (HAT) for Mn(IV)(O)(TBP8Cz( +)):LA with phenols.	radical	19-26	par-3 family cell polarity regulator	Homo sapiens	100-104
25626151-3	2015	Our investigations revealed that the reaction followed indirect scattering dynamics through the formation of (11)BOC4H6 doublet radical intermediates via the barrierless addition of the (11)BO radical to the terminal carbon atom (C1/C4) and/or the central carbon atom (C2/C3) of 1,3-butadiene.	radical	128-135	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	230-236
24501102-3	2014	Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule.	radical	67-74	paraoxonase 1	Homo sapiens	15-19
24288134-9	2014	Radical species were detected through electron paramagnetic resonance (EPR) spectroscopic analysis arising from coincubation of DA/Cu2+ with alpha-synuclein.	radical	0-7	synuclein alpha	Homo sapiens	141-156
25072999-2	2014	Titration of the carbon-centered radical, formed following the initial OH abstraction, with oxygen to give HO2 and an imine, followed by conversion of HO2 to OH by reaction with NO, resulted in biexponential OH decay traces on a millisecond time scale.	radical	33-40	heme oxygenase 2	Homo sapiens	107-110
25072999-2	2014	Titration of the carbon-centered radical, formed following the initial OH abstraction, with oxygen to give HO2 and an imine, followed by conversion of HO2 to OH by reaction with NO, resulted in biexponential OH decay traces on a millisecond time scale.	radical	33-40	heme oxygenase 2	Homo sapiens	151-154
23207144-9	2013	Markers of free radical formation were significantly decreased by the peroxynitrite decomposition catalyst FeTPPS, the iNOS inhibitor 1400W, the NADPH oxidase inhibitor apocynin, or in iNOS or p47 phox-deficient mice.	radical	16-23	nitric oxide synthase 2, inducible	Mus musculus	119-123
24186356-2	2014	Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule.	radical	67-74	paraoxonase 1	Homo sapiens	0-13
24186356-2	2014	Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule.	radical	67-74	paraoxonase 1	Homo sapiens	15-19
24171583-3	2013	We report a study of the radical (OH, HO2, and RO2) production from a series of small alkenes (propene, 1-butene, cis-2-butene, trans-2-butene, 2-methylpropene, 2,3-dimethyl-2-butene (tetramethyl ethene, TME), and isoprene).	radical	25-32	heme oxygenase 2	Homo sapiens	38-41
23207144-9	2013	Markers of free radical formation were significantly decreased by the peroxynitrite decomposition catalyst FeTPPS, the iNOS inhibitor 1400W, the NADPH oxidase inhibitor apocynin, or in iNOS or p47 phox-deficient mice.	radical	16-23	nitric oxide synthase 2, inducible	Mus musculus	185-189
23207144-9	2013	Markers of free radical formation were significantly decreased by the peroxynitrite decomposition catalyst FeTPPS, the iNOS inhibitor 1400W, the NADPH oxidase inhibitor apocynin, or in iNOS or p47 phox-deficient mice.	radical	16-23	neutrophil cytosolic factor 1	Mus musculus	193-201
23252580-9	2013	These data point to a complex mechanism of peroxyl-radical mediated modification of proteins with monomeric (LYSO), dimeric (G6PD), and multimeric (BLP) structural organization, which not only results in oxidation of protein side chains but also gives rise to radical-mediated protein cross-links and fragmentation, with Trp species being critical intermediates.	radical	51-58	glucose-6-phosphate dehydrogenase	Bos taurus	125-129
23231091-1	2013	An "open"-state crystal structure of lysine 5,6-aminomutase suggests that transition to a hypothetical "closed"-state is required to bring the cofactors adenosylcobalamin (AdoCbl) and pyridoxal-5"-phosphate (PLP) and the substrate into proximity for the radical-mediated 1,2-amino group migration.	radical	254-261	pyridoxal phosphatase	Homo sapiens	208-211
23252580-9	2013	These data point to a complex mechanism of peroxyl-radical mediated modification of proteins with monomeric (LYSO), dimeric (G6PD), and multimeric (BLP) structural organization, which not only results in oxidation of protein side chains but also gives rise to radical-mediated protein cross-links and fragmentation, with Trp species being critical intermediates.	radical	51-58	lysozyme C, tracheal isozyme	Bos taurus	109-113
21545835-5	2011	Studies were performed to understand the related mechanisms of radical generation and NADH oxidation by Fe3+cyt c in the presence of H2O2.	radical	63-70	cytochrome c, somatic	Homo sapiens	108-113
22846601-8	2012	SOD must favor reduction of oxygen by the INH radical to give superoxide and ultimately hydrogen peroxide.	radical	46-53	superoxide dismutase 1	Homo sapiens	0-3
22097883-0	2012	Radical-mediated enzymatic methylation: a tale of two SAMS.	radical	0-7	methionine adenosyltransferase 1A	Homo sapiens	54-58
21494773-0	2011	Use of Raman spectroscopy for the identification of radical-mediated damages in human serum albumin.	radical	52-59	albumin	Homo sapiens	86-99
21355852-4	2011	Specific inhibition of both the TRX-2 and mGSH systems increased the intracellular total radical production (P<0.05) and reduced mitochondrial membrane potentials (P<0.05).	radical	89-96	thioredoxin 2	Homo sapiens	32-37
21076111-6	2010	Antioxidant activity measured as 2,2-azino-bis [3-ethylbenzo-thiazoline-6-sulfonic acid] radical scavenging capacity in the thigh meat from CAM2.5, CAM5, and CAM10 was higher than control birds (P < 0.05).	radical	89-96	calmodulin-2	Glycine max	140-144
20839220-8	2011	These radical intermediates could also be ligands that interact with aryl hydrocarbon receptor (AhR) and induce xenobiotic metabolizing enzymes (XMEs) to metabolize contaminated carcinogens.	radical	6-13	aryl hydrocarbon receptor	Homo sapiens	69-94
20839220-8	2011	These radical intermediates could also be ligands that interact with aryl hydrocarbon receptor (AhR) and induce xenobiotic metabolizing enzymes (XMEs) to metabolize contaminated carcinogens.	radical	6-13	aryl hydrocarbon receptor	Homo sapiens	96-99