PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31019651-5	2019	We found that gamma-mangostin exhibited prominent protection against H2O2- or xanthine/xanthine oxidase-induced oxidative neuronal death and inhibited reactive oxygen species (ROS) generation triggered by these oxidative insults.	gamma-mangostin	14-29	xanthine dehydrogenase	Mus musculus	87-103
33514017-4	2021	gamma-Mangostin showed prevented glutamate-induced apoptosis in HT22 cells by reducing the production of reactive oxygen species and stimulating the expression of heme oxygenase-1 protein.	gamma-mangostin	0-15	heme oxygenase 1	Mus musculus	163-179
33514017-7	2021	Furthermore, the number of annexin V-positive cells was significantly reduced following treatment with gamma-mangostin.	gamma-mangostin	103-118	annexin A5	Mus musculus	27-36
31711765-6	2020	It was demonstrated that gamma-mangostin was able to increase the alpha-tubulin acetylation in MDA-MD-231 and MCF-7 breast cancer cells.	gamma-mangostin	25-40	tubulin alpha 1b	Homo sapiens	66-79
34998794-8	2022	RESULTS: gamma-Mangostin alleviated Abeta42 oligomer-induced inflammation by decreasing the levels of interleukin (IL) -6, IL-1beta, and tumor necrosis factor-alpha, while attenuating OS through decreasing ROS/NO generation, and suppressing cyclo-oxygenase-2 and inducible NO synthase expressions.	gamma-mangostin	9-24	interleukin 6	Mus musculus	102-121
34998794-8	2022	RESULTS: gamma-Mangostin alleviated Abeta42 oligomer-induced inflammation by decreasing the levels of interleukin (IL) -6, IL-1beta, and tumor necrosis factor-alpha, while attenuating OS through decreasing ROS/NO generation, and suppressing cyclo-oxygenase-2 and inducible NO synthase expressions.	gamma-mangostin	9-24	interleukin 1 alpha	Mus musculus	123-131
34998794-8	2022	RESULTS: gamma-Mangostin alleviated Abeta42 oligomer-induced inflammation by decreasing the levels of interleukin (IL) -6, IL-1beta, and tumor necrosis factor-alpha, while attenuating OS through decreasing ROS/NO generation, and suppressing cyclo-oxygenase-2 and inducible NO synthase expressions.	gamma-mangostin	9-24	tumor necrosis factor	Mus musculus	137-164
34998794-8	2022	RESULTS: gamma-Mangostin alleviated Abeta42 oligomer-induced inflammation by decreasing the levels of interleukin (IL) -6, IL-1beta, and tumor necrosis factor-alpha, while attenuating OS through decreasing ROS/NO generation, and suppressing cyclo-oxygenase-2 and inducible NO synthase expressions.	gamma-mangostin	9-24	prostaglandin-endoperoxide synthase 2	Mus musculus	241-258
34998794-8	2022	RESULTS: gamma-Mangostin alleviated Abeta42 oligomer-induced inflammation by decreasing the levels of interleukin (IL) -6, IL-1beta, and tumor necrosis factor-alpha, while attenuating OS through decreasing ROS/NO generation, and suppressing cyclo-oxygenase-2 and inducible NO synthase expressions.	gamma-mangostin	9-24	nitric oxide synthase 2, inducible	Mus musculus	263-284
34998794-10	2022	Furthermore, gamma-mangostin inhibited c-Jun NH2-terminal kinase and p38 MAPK pathway activation.	gamma-mangostin	13-28	mitogen-activated protein kinase 14	Mus musculus	69-77
31674780-0	2019	gamma-Mangostin Ameliorates Free Fatty Acid-Induced Lipid Accumulation via the SIRT1/LKB1/AMPK Pathway in HepG2 and L02 Cells.	gamma-mangostin	0-15	sirtuin 1	Homo sapiens	79-84
31674780-0	2019	gamma-Mangostin Ameliorates Free Fatty Acid-Induced Lipid Accumulation via the SIRT1/LKB1/AMPK Pathway in HepG2 and L02 Cells.	gamma-mangostin	0-15	serine/threonine kinase 11	Homo sapiens	85-89
31674780-0	2019	gamma-Mangostin Ameliorates Free Fatty Acid-Induced Lipid Accumulation via the SIRT1/LKB1/AMPK Pathway in HepG2 and L02 Cells.	gamma-mangostin	0-15	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	90-94
31674780-4	2019	Analysis of the inhibitory effects of gamma-mangostin on lipid accumulation revealed that it downregulated NAFLD-related biochemical parameters and stimulated the SIRT1/LKB1/AMPK pathway.	gamma-mangostin	38-53	sirtuin 1	Homo sapiens	163-168
31674780-4	2019	Analysis of the inhibitory effects of gamma-mangostin on lipid accumulation revealed that it downregulated NAFLD-related biochemical parameters and stimulated the SIRT1/LKB1/AMPK pathway.	gamma-mangostin	38-53	serine/threonine kinase 11	Homo sapiens	169-173
31674780-4	2019	Analysis of the inhibitory effects of gamma-mangostin on lipid accumulation revealed that it downregulated NAFLD-related biochemical parameters and stimulated the SIRT1/LKB1/AMPK pathway.	gamma-mangostin	38-53	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	174-178
31019651-7	2019	We also found that gamma-mangostin, not alpha-mangostin, significantly inhibited H2O2-induced DNA fragmentation and activation of caspases 3 and 9, demonstrating its antiapoptotic action.	gamma-mangostin	19-34	caspase 3	Mus musculus	130-146
29195909-7	2018	Furthermore, a significant suppression of p-p38, improved Bax/Bcl-2 ratio expression, and reduced caspase-3 activity was exhibited in the cells after gamma-mangostin pretreatment.	gamma-mangostin	150-165	mitogen-activated protein kinase 14	Homo sapiens	44-47
30502394-0	2019	gamma-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis.	gamma-mangostin	0-15	sirtuin 3	Homo sapiens	50-59
30502394-0	2019	gamma-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis.	gamma-mangostin	0-15	high mobility group box 1	Homo sapiens	71-96
30502394-2	2019	In the current study, gamma-mangostin (gamma-man), one of the major xanthones from mangosteen (Garcinia mangostana), was found to alleviate fibrogenesis in human immortalized HSCs (LX-2 cells) and in liver from chronic carbon tetrachloride (CCl4) injured mice.	gamma-mangostin	22-37	C-C motif chemokine ligand 4	Homo sapiens	241-245
29684706-3	2018	It was shown that gamma-mangostin and its C-4/C-5-derivatives were superior to alpha-mangostin and its derivatives in all the investigated parameters characterizing the antioxidant activity in the test systems used.	gamma-mangostin	18-33	complement C4A (Rodgers blood group)	Homo sapiens	42-45
29684706-3	2018	It was shown that gamma-mangostin and its C-4/C-5-derivatives were superior to alpha-mangostin and its derivatives in all the investigated parameters characterizing the antioxidant activity in the test systems used.	gamma-mangostin	18-33	complement C5	Homo sapiens	46-49
29195909-7	2018	Furthermore, a significant suppression of p-p38, improved Bax/Bcl-2 ratio expression, and reduced caspase-3 activity was exhibited in the cells after gamma-mangostin pretreatment.	gamma-mangostin	150-165	BCL2 associated X, apoptosis regulator	Homo sapiens	58-61
29195909-7	2018	Furthermore, a significant suppression of p-p38, improved Bax/Bcl-2 ratio expression, and reduced caspase-3 activity was exhibited in the cells after gamma-mangostin pretreatment.	gamma-mangostin	150-165	BCL2 apoptosis regulator	Homo sapiens	62-67
29195909-7	2018	Furthermore, a significant suppression of p-p38, improved Bax/Bcl-2 ratio expression, and reduced caspase-3 activity was exhibited in the cells after gamma-mangostin pretreatment.	gamma-mangostin	150-165	caspase 3	Homo sapiens	98-107
27038926-4	2016	Among these compounds, alpha-Mangostin, Gartanin, Garcinone C and gamma-Mangostin showed better antioxidant properties to scavenge Diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) free radical than Trolox, and potent neuroprotective effects against glutamate-induced HT22 cell death partly by up-regulating HO-1 protein level and then scavenging reactive oxygen species.	gamma-mangostin	66-81	heme oxygenase 1	Mus musculus	308-312
24175297-6	2013	gamma-Mangostin significantly downregulated mRNA expression of Akt1 and NFkappaB and upregulated p21(WAF1) and IkappaBalpha.	gamma-mangostin	0-15	AKT serine/threonine kinase 1	Homo sapiens	63-67
26310724-3	2015	Herein, we discovered that gamma-mangostin (gamma-M) is an effective inhibitor against the amyloid fibril formation of V30M amyloidogenic TTR.	gamma-mangostin	27-42	transthyretin	Homo sapiens	138-141
26310724-8	2015	The present study establishes gamma-M as a novel inhibitor of TTR fibrillization.	gamma-mangostin	30-37	transthyretin	Homo sapiens	62-65
24317060-0	2013	gamma-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARalpha and PPARdelta.	gamma-mangostin	0-15	peroxisome proliferator activated receptor alpha	Homo sapiens	89-98
24317060-0	2013	gamma-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARalpha and PPARdelta.	gamma-mangostin	0-15	peroxisome proliferator activated receptor delta	Homo sapiens	103-112
24317060-3	2013	We showed that gamma-mangostin is a dual agonist that activates both PPARdelta and PPARalpha.	gamma-mangostin	15-30	peroxisome proliferator activated receptor delta	Homo sapiens	69-78
24317060-3	2013	We showed that gamma-mangostin is a dual agonist that activates both PPARdelta and PPARalpha.	gamma-mangostin	15-30	peroxisome proliferator activated receptor alpha	Homo sapiens	83-92
24175297-6	2013	gamma-Mangostin significantly downregulated mRNA expression of Akt1 and NFkappaB and upregulated p21(WAF1) and IkappaBalpha.	gamma-mangostin	0-15	nuclear factor kappa B subunit 1	Homo sapiens	72-80
24175297-6	2013	gamma-Mangostin significantly downregulated mRNA expression of Akt1 and NFkappaB and upregulated p21(WAF1) and IkappaBalpha.	gamma-mangostin	0-15	cyclin dependent kinase inhibitor 1A	Homo sapiens	97-100
24175297-6	2013	gamma-Mangostin significantly downregulated mRNA expression of Akt1 and NFkappaB and upregulated p21(WAF1) and IkappaBalpha.	gamma-mangostin	0-15	cyclin dependent kinase inhibitor 1A	Homo sapiens	101-105
24175297-6	2013	gamma-Mangostin significantly downregulated mRNA expression of Akt1 and NFkappaB and upregulated p21(WAF1) and IkappaBalpha.	gamma-mangostin	0-15	NFKB inhibitor alpha	Homo sapiens	111-123
23123477-4	2012	Molecular docking of the two mangostins in AKR1B10 and site-directed mutagenesis of the putative binding residues revealed that Phe123, Trp220, Val301 and Gln303 are important for the tight binding of gamma-mangostin, and suggested that the 7-methoxy group of alpha-mangostin impairs the inhibitory potency by altering the orientation of the inhibitor molecule in the substrate-binding site of the enzyme.	gamma-mangostin	201-216	aldo-keto reductase family 1 member B10	Homo sapiens	43-50
15322259-0	2004	gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.	gamma-mangostin	0-15	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	99-115
9459569-7	1998	These results suggest that gamma-mangostin is a novel competitive antagonist, free from a nitrogen atom, for the 5-HT2A receptors in vascular smooth muscles and platelets.	gamma-mangostin	27-42	5-hydroxytryptamine receptor 2A	Rattus norvegicus	113-119
9535013-14	1998	Gamma-mangostin caused a concentration-dependent inhibition of the binding of [3H]-spiperone, a specific 5-HT2A receptor antagonist, to mouse brain membranes.	gamma-mangostin	0-15	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	105-120
9535013-18	1998	These results suggest that gamma-mangostin inhibits 5-FMT-induced head-twitch response in mice by blocking 5-HT2A receptors not by blocking the release of 5-HT from the central neurone.	gamma-mangostin	27-42	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	107-113
9535013-19	1998	Gamma-mangostin is a promising 5-HT2A receptor antagonist in the central nervous system.	gamma-mangostin	0-15	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	31-46
9459569-2	1998	The perfusion pressure response of rat coronary artery to 5-HT (5-HT2A) was reduced concentration dependently by gamma-mangostin (IC50 = 0.32 microM).	gamma-mangostin	113-128	5-hydroxytryptamine receptor 2A	Rattus norvegicus	64-70
34678724-0	2021	Mangosteen xanthone gamma-mangostin exerts lowering blood glucose effect with potentiating insulin sensitivity through the mediation of AMPK/PPARgamma.	gamma-mangostin	20-35	peroxisome proliferator activated receptor gamma	Mus musculus	141-150
9459569-3	1998	5-HT amplified, ADP-induced aggregation of rabbit platelets (5-HT2A) was inhibited by gamma-mangostin (IC50 = 0.29 microM), whereas that induced by thrombin was not affected, nor did gamma-mangostin affect 5-HT-induced contraction of the guinea-pig ileum (5-HT3)in the presence of 5-HT1, 5-HT2 and 5-HT4 receptor antagonists.	gamma-mangostin	86-101	5-hydroxytryptamine receptor 2A	Rattus norvegicus	61-67
34802869-0	2022	Gamma-mangostin isolated from garcinia mangostana suppresses colon carcinogenesis and stemness by downregulating the GSK3beta/beta-catenin/CDK6 cancer stem pathway.	gamma-mangostin	0-15	glycogen synthase kinase 3 alpha	Homo sapiens	117-125
34802869-0	2022	Gamma-mangostin isolated from garcinia mangostana suppresses colon carcinogenesis and stemness by downregulating the GSK3beta/beta-catenin/CDK6 cancer stem pathway.	gamma-mangostin	0-15	catenin (cadherin associated protein), beta 1	Mus musculus	126-138
34802869-0	2022	Gamma-mangostin isolated from garcinia mangostana suppresses colon carcinogenesis and stemness by downregulating the GSK3beta/beta-catenin/CDK6 cancer stem pathway.	gamma-mangostin	0-15	cyclin-dependent kinase 6	Mus musculus	139-143
34802869-4	2022	HYPOTHESIS: Gamma-mangostin (gMG) isolated from Garcinia mangostana was evaluated for its ability to downregulate GSK3beta-associated signaling in CRC cells and overcome CAF-induced 5-fluorouracil resistance and CSC generation.	gamma-mangostin	12-27	glycogen synthase kinase 3 alpha	Homo sapiens	114-122
34802869-4	2022	HYPOTHESIS: Gamma-mangostin (gMG) isolated from Garcinia mangostana was evaluated for its ability to downregulate GSK3beta-associated signaling in CRC cells and overcome CAF-induced 5-fluorouracil resistance and CSC generation.	gamma-mangostin	29-32	glycogen synthase kinase 3 alpha	Homo sapiens	114-122
34802869-5	2022	METHODS: Bioinformatics analysis, in silico molecular docking, in vitro assays, including cell viability tests, colony- and tumor sphere-formation assays, transwell migration assays, ELISA, SDS-PAGE, Western blotting, miR expression, qPCR, and flow cytometry, as well as in vivo mouse xenograft models were used to evaluate the antitumor effects of gMG.	gamma-mangostin	349-352	microRNA 615	Mus musculus	218-221
34802869-9	2022	Therapeutically, we demonstrated that gMG treatment suppressed GSK3beta-associated signaling pathways while concomitantly increased the miR-26b-5p level.	gamma-mangostin	38-41	glycogen synthase kinase 3 alpha	Homo sapiens	63-71
34802869-11	2022	CONCLUSIONS: Pharmacological intervention with gMG suppressed CRC carcinogenesis and stemness via downregulating GSK3/beta-catenin/CDK6 and upregulating the miR-26b-5p tumor suppressor.	gamma-mangostin	47-50	catenin (cadherin associated protein), beta 1	Mus musculus	118-130
34802869-11	2022	CONCLUSIONS: Pharmacological intervention with gMG suppressed CRC carcinogenesis and stemness via downregulating GSK3/beta-catenin/CDK6 and upregulating the miR-26b-5p tumor suppressor.	gamma-mangostin	47-50	cyclin-dependent kinase 6	Mus musculus	131-135
34678724-7	2021	Moreover, AMPK, PPARgamma, alpha-amylase, and alpha-glucosidase were found to be the potential targets for simulating binds with gamma-mangostin after molecular docking.	gamma-mangostin	129-144	peroxisome proliferator activated receptor gamma	Mus musculus	16-25
34678724-7	2021	Moreover, AMPK, PPARgamma, alpha-amylase, and alpha-glucosidase were found to be the potential targets for simulating binds with gamma-mangostin after molecular docking.	gamma-mangostin	129-144	sucrase isomaltase (alpha-glucosidase)	Mus musculus	46-63
34678724-8	2021	To validate the docking results, the inhibitory potency of gamma-mangostin againstalpha-amylase/alpha-glucosidase was higher than Acarbose via enzymatic assay.	gamma-mangostin	59-74	sucrase isomaltase (alpha-glucosidase)	Mus musculus	96-113
34678724-10	2021	Taken together, the results showed that gamma-mangostin exerts anti-hyperglycemic activity through promoting glucose uptake and reducing saccharide digestion by inhibition of alpha-amylase/alpha-glucosidase with insulin sensitization, suggesting that gamma-mangostin could be a new clue for drug discovery and development to treat diabetes.	gamma-mangostin	40-55	sucrase isomaltase (alpha-glucosidase)	Mus musculus	189-206
34678724-10	2021	Taken together, the results showed that gamma-mangostin exerts anti-hyperglycemic activity through promoting glucose uptake and reducing saccharide digestion by inhibition of alpha-amylase/alpha-glucosidase with insulin sensitization, suggesting that gamma-mangostin could be a new clue for drug discovery and development to treat diabetes.	gamma-mangostin	251-266	sucrase isomaltase (alpha-glucosidase)	Mus musculus	189-206
34498967-4	2021	Meanwhile, compounds 5-10 were investigated for their inhibitory effects towards alpha-glucosidase, and gamma-mangostin (5) exhibited the most remarkable effect with IC50 value of 15.3 +- 0.9 microM (compared with acarbose, IC50 = 224.9 +- 3.6 microM).	gamma-mangostin	104-119	sucrase-isomaltase	Homo sapiens	81-98