PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32960565-0	2020	Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3beta Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity.	aminopyrazoles	37-51	glycogen synthase kinase 3 alpha	Mus musculus	61-70
33444025-3	2021	We recently described resorcylate aminopyrazoles (RAPs) as the first class of Hsp90 inhibitors capable of discriminating between fungal (Cryptococcus neoformans, Candida albicans) and human isoforms of Hsp90 in biochemical assays.	aminopyrazoles	34-48	heat shock protein 90 alpha family class A member 1	Homo sapiens	78-83
33444025-3	2021	We recently described resorcylate aminopyrazoles (RAPs) as the first class of Hsp90 inhibitors capable of discriminating between fungal (Cryptococcus neoformans, Candida albicans) and human isoforms of Hsp90 in biochemical assays.	aminopyrazoles	34-48	heat shock protein 90 alpha family class A member 1	Homo sapiens	202-207
32601168-6	2020	The potential role of efflux pumps (MDR/MRP) in the development of resistance was assessed by co-incubation of aminopyrazoles with specific efflux pump inhibitors (verapamil, cyclosporine A and probenecid).Results: Repeated drug exposure of amastigotes did not result in the emergence of drug resistance, either in vitro or in vivo Selection on the promastigote stage, however, was able to select for parasites with reduced susceptibility (resistance index: 5-24).	aminopyrazoles	111-125	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	40-43
25623238-0	2015	Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles.	aminopyrazoles	74-88	mitogen-activated protein kinase 9	Homo sapiens	49-55
27096042-3	2016	Herein we report a further development of those compounds and in particular the validation of the hypothesis that aminoheterocycles such as aminoisoxazoles and aminopyrazoles could also function as effective "hinge" binding moieties leading to a new class of KDR (kinase insert domain containing receptor) inhibitors.	aminopyrazoles	160-174	kinase insert domain receptor	Homo sapiens	264-304
27096042-3	2016	Herein we report a further development of those compounds and in particular the validation of the hypothesis that aminoheterocycles such as aminoisoxazoles and aminopyrazoles could also function as effective "hinge" binding moieties leading to a new class of KDR (kinase insert domain containing receptor) inhibitors.	aminopyrazoles	160-174	kinase insert domain receptor	Homo sapiens	259-262
34715306-3	2021	In this report we explore substituted aminopyrazoles and 7-azaindoles as potent inhibitors for the Nek1 kinase domain and examine their effect on kidney organogenesis in Danio rerio.	aminopyrazoles	38-52	NIMA-related kinase 1	Danio rerio	99-103
24900567-2	2013	By using aminopyrazoles as aniline bioisosteres, we discovered a novel series of LRRK2 inhibitors.	aminopyrazoles	9-23	leucine rich repeat kinase 2	Homo sapiens	81-86