PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31299112-9 2019 Furthermore, Ikaros knockdown increased the expression of BCR pathway components in murine B-1 cells, such as Lyn, Blnk, and CD19. ikaros 13-19 LYN proto-oncogene, Src family tyrosine kinase Mus musculus 110-113 31299112-9 2019 Furthermore, Ikaros knockdown increased the expression of BCR pathway components in murine B-1 cells, such as Lyn, Blnk, and CD19. ikaros 13-19 B cell linker Mus musculus 115-119 30802347-4 2019 We were also able to tune the activity of these molecules against Ikaros (IKZF1) and Aiolos (IKZF3), which are well-established targets of imide-based degraders. ikaros 66-72 IKAROS family zinc finger 1 Homo sapiens 74-79 28425720-5 2018 The crystal structure of cereblon in complex with DDB1 and compound 6 reveals that the increase in potency correlates with increased contacts between compound 6 and cereblon away from the modeled binding site for Ikaros/Aiolos. ikaros 213-219 damage specific DNA binding protein 1 Homo sapiens 50-54 30978178-4 2019 We find that the coordinated regulation of housekeeping functions and tissue-specific gene expression requires a feedforward circuit whereby Ikaros down-regulates the expression of Myc. ikaros 141-147 MYC proto-oncogene, bHLH transcription factor Homo sapiens 181-184 30319648-10 2018 Interestingly, the mechanism of immune activation by IMiDs also involves release of inhibitory checkpoints, such as Ikaros-mediated suppression of IL-2. ikaros 116-122 interleukin 2 Homo sapiens 147-151 29296813-5 2017 The development of murine Arf-/- pre-B ALL expressing RCSD1-ABL2 or SSBP2-CSF1R was accelerated with the presence of IK6, a dominant negative isoform of Ikaros common in Ph-like ALL, providing evidence that these fusions are leukemogenic. ikaros 153-159 RCSD domain containing 1 Mus musculus 54-59 29296813-5 2017 The development of murine Arf-/- pre-B ALL expressing RCSD1-ABL2 or SSBP2-CSF1R was accelerated with the presence of IK6, a dominant negative isoform of Ikaros common in Ph-like ALL, providing evidence that these fusions are leukemogenic. ikaros 153-159 v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) Mus musculus 60-64 29296813-5 2017 The development of murine Arf-/- pre-B ALL expressing RCSD1-ABL2 or SSBP2-CSF1R was accelerated with the presence of IK6, a dominant negative isoform of Ikaros common in Ph-like ALL, providing evidence that these fusions are leukemogenic. ikaros 153-159 single-stranded DNA binding protein 2 Mus musculus 68-73 28190000-4 2017 Comparison of transcriptional profiles accompanying dynamic Ikaros perturbation in murine B-ALL in vivo with two independent human B-ALL cohorts identified nine evolutionarily conserved IKAROS-repressed genes. ikaros 60-66 IKAROS family zinc finger 1 Homo sapiens 186-192 28190000-7 2017 We demonstrate that elevated Ctnnd1 expression contributes to maintenance of murine B-ALL cells with compromised Ikaros function. ikaros 113-119 catenin (cadherin associated protein), delta 1 Mus musculus 29-35 27142104-1 2016 BACKGROUND: Immunomodulatory drugs (IMiDs), such as lenalidomide, are therapeutically active compounds that bind and modulate the E3 ubiquitin ligase substrate recruiter cereblon, thereby affect steady-state levels of cereblon and cereblon binding partners, such as ikaros and aiolos, and induce many cellular responses, including cytotoxicity to multiple myeloma (MM) cells. ikaros 266-272 Cbl proto-oncogene like 2 Homo sapiens 130-149 27460676-6 2016 Each IMiD binds to CRBN and alters the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins such as Ikaros and Aiolos. ikaros 166-172 cereblon Homo sapiens 19-23 27460676-6 2016 Each IMiD binds to CRBN and alters the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins such as Ikaros and Aiolos. ikaros 166-172 cereblon Homo sapiens 68-72 27447561-0 2016 Targeting of heme oxygenase-1 attenuates the negative impact of Ikaros isoform 6 in adult BCR-ABL1-positive B-ALL. ikaros 64-70 heme oxygenase 1 Homo sapiens 13-29 27447561-0 2016 Targeting of heme oxygenase-1 attenuates the negative impact of Ikaros isoform 6 in adult BCR-ABL1-positive B-ALL. ikaros 64-70 BCR activator of RhoGEF and GTPase Homo sapiens 90-98 27707884-0 2017 Ikaros 6 protects acute lymphoblastic leukemia cells against daunorubicin-induced apoptosis by activating the Akt-FoxO1 pathway. ikaros 0-6 AKT serine/threonine kinase 1 Homo sapiens 110-113 27707884-0 2017 Ikaros 6 protects acute lymphoblastic leukemia cells against daunorubicin-induced apoptosis by activating the Akt-FoxO1 pathway. ikaros 0-6 forkhead box O1 Homo sapiens 114-119 28074872-0 2017 Corrigendum: Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia. ikaros 69-75 dynamin 2 Homo sapiens 28-37 28074872-0 2017 Corrigendum: Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia. ikaros 69-75 dynamin 2 Homo sapiens 39-43 25214003-0 2014 Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia. ikaros 64-70 inorganic pyrophosphatase 1 Homo sapiens 0-21 27606333-3 2015 The zinc finger transcription factor Ikzf1 (Ikaros), an ortholog of Drosophila hunchback, was reported to confer early temporal identity in retinal progenitors and, more recently, the ortholog of Drosophila castor, Casz1, was found to function as a mid/late temporal identity factor that is negatively regulated by Ikzf1. ikaros 44-50 hunchback Drosophila melanogaster 79-88 25214003-7 2014 RESULTS: We demonstrate that phosphorylation of Ikaros by pro-oncogenic CK2 decreases Ikaros binding to the promoter of the TdT gene and reduces the ability of Ikaros to repress TdT expression during thymocyte differentiation. ikaros 48-54 DNA nucleotidylexotransferase Homo sapiens 124-127 25214003-0 2014 Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia. ikaros 64-70 inorganic pyrophosphatase 1 Homo sapiens 23-26 25214003-7 2014 RESULTS: We demonstrate that phosphorylation of Ikaros by pro-oncogenic CK2 decreases Ikaros binding to the promoter of the TdT gene and reduces the ability of Ikaros to repress TdT expression during thymocyte differentiation. ikaros 48-54 DNA nucleotidylexotransferase Homo sapiens 178-181 25214003-0 2014 Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia. ikaros 64-70 DNA nucleotidylexotransferase Homo sapiens 94-97 25214003-7 2014 RESULTS: We demonstrate that phosphorylation of Ikaros by pro-oncogenic CK2 decreases Ikaros binding to the promoter of the TdT gene and reduces the ability of Ikaros to repress TdT expression during thymocyte differentiation. ikaros 86-92 DNA nucleotidylexotransferase Homo sapiens 124-127 25214003-7 2014 RESULTS: We demonstrate that phosphorylation of Ikaros by pro-oncogenic CK2 decreases Ikaros binding to the promoter of the TdT gene and reduces the ability of Ikaros to repress TdT expression during thymocyte differentiation. ikaros 86-92 DNA nucleotidylexotransferase Homo sapiens 178-181 25214003-7 2014 RESULTS: We demonstrate that phosphorylation of Ikaros by pro-oncogenic CK2 decreases Ikaros binding to the promoter of the TdT gene and reduces the ability of Ikaros to repress TdT expression during thymocyte differentiation. ikaros 86-92 DNA nucleotidylexotransferase Homo sapiens 124-127 25214003-2 2014 In thymocytes and T-cell leukemia, Ikaros negatively regulates transcription of terminal deoxynucleotide transferase (TdT), a key protein in lymphocyte differentiation. ikaros 35-41 DNA nucleotidylexotransferase Homo sapiens 80-116 25214003-7 2014 RESULTS: We demonstrate that phosphorylation of Ikaros by pro-oncogenic CK2 decreases Ikaros binding to the promoter of the TdT gene and reduces the ability of Ikaros to repress TdT expression during thymocyte differentiation. ikaros 86-92 DNA nucleotidylexotransferase Homo sapiens 178-181 25214003-8 2014 CK2 inhibition and PP1 activity restore Ikaros DNA-binding affinity toward the TdT promoter, as well as Ikaros-mediated transcriptional repression of TdT in primary thymocytes and in leukemia. ikaros 40-46 inorganic pyrophosphatase 1 Homo sapiens 19-22 25214003-8 2014 CK2 inhibition and PP1 activity restore Ikaros DNA-binding affinity toward the TdT promoter, as well as Ikaros-mediated transcriptional repression of TdT in primary thymocytes and in leukemia. ikaros 40-46 DNA nucleotidylexotransferase Homo sapiens 79-82 25214003-8 2014 CK2 inhibition and PP1 activity restore Ikaros DNA-binding affinity toward the TdT promoter, as well as Ikaros-mediated transcriptional repression of TdT in primary thymocytes and in leukemia. ikaros 104-110 inorganic pyrophosphatase 1 Homo sapiens 19-22 25214003-8 2014 CK2 inhibition and PP1 activity restore Ikaros DNA-binding affinity toward the TdT promoter, as well as Ikaros-mediated transcriptional repression of TdT in primary thymocytes and in leukemia. ikaros 104-110 DNA nucleotidylexotransferase Homo sapiens 150-153 25214003-9 2014 CONCLUSION: These data establish that PP1 and CK2 signal transduction pathways regulate Ikaros-mediated repression of TdT in thymocytes and leukemia. ikaros 88-94 inorganic pyrophosphatase 1 Homo sapiens 38-41 25214003-9 2014 CONCLUSION: These data establish that PP1 and CK2 signal transduction pathways regulate Ikaros-mediated repression of TdT in thymocytes and leukemia. ikaros 88-94 DNA nucleotidylexotransferase Homo sapiens 118-121 25214003-10 2014 These findings reveal that PP1 and CK2 have opposing effects on Ikaros-mediated repression of TdT and establish novel roles for PP1 and CK2 signaling in thymocyte differentiation and leukemia. ikaros 64-70 inorganic pyrophosphatase 1 Homo sapiens 27-30 25214003-2 2014 In thymocytes and T-cell leukemia, Ikaros negatively regulates transcription of terminal deoxynucleotide transferase (TdT), a key protein in lymphocyte differentiation. ikaros 35-41 DNA nucleotidylexotransferase Homo sapiens 118-121 25214003-3 2014 The signaling pathways that regulate Ikaros-mediated repression of TdT are unknown. ikaros 37-43 DNA nucleotidylexotransferase Homo sapiens 67-70 25214003-5 2014 Here, we investigated the role of PP1 and CK2 in regulating Ikaros-mediated control of TdT expression. ikaros 60-66 inorganic pyrophosphatase 1 Homo sapiens 34-37 25214003-5 2014 Here, we investigated the role of PP1 and CK2 in regulating Ikaros-mediated control of TdT expression. ikaros 60-66 DNA nucleotidylexotransferase Homo sapiens 87-90 24328678-0 2014 Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.). ikaros 120-126 interleukin 17 receptor B Homo sapiens 188-192 25214003-10 2014 These findings reveal that PP1 and CK2 have opposing effects on Ikaros-mediated repression of TdT and establish novel roles for PP1 and CK2 signaling in thymocyte differentiation and leukemia. ikaros 64-70 DNA nucleotidylexotransferase Homo sapiens 94-97 25214003-10 2014 These findings reveal that PP1 and CK2 have opposing effects on Ikaros-mediated repression of TdT and establish novel roles for PP1 and CK2 signaling in thymocyte differentiation and leukemia. ikaros 64-70 inorganic pyrophosphatase 1 Homo sapiens 128-131 25108355-2 2014 These drugs directly bind Cereblon (CRBN) and promote the recruitment of substrates Ikaros (IKZF1) and Aiolos (IKZF3) to the E3 complex, thus leading to substrate ubiquitination and degradation. ikaros 84-90 IKAROS family zinc finger 1 Homo sapiens 92-97 24328678-4 2014 Each agent promotes Aiolos and Ikaros binding to CRL4(CRBN) with enhanced ubiquitination leading to cereblon-dependent proteosomal degradation in T lymphocytes. ikaros 31-37 interleukin 17 receptor B Homo sapiens 49-53 23977012-0 2013 Regulatory phosphorylation of Ikaros by Bruton"s tyrosine kinase. ikaros 30-36 Bruton tyrosine kinase Homo sapiens 40-64 24328678-4 2014 Each agent promotes Aiolos and Ikaros binding to CRL4(CRBN) with enhanced ubiquitination leading to cereblon-dependent proteosomal degradation in T lymphocytes. ikaros 31-37 cereblon Homo sapiens 54-58 24328678-8 2014 In conclusion, we present a molecular model in which drug binding to cereblon results in the interaction of Ikaros and Aiolos to CRL4(CRBN) , leading to their ubiquitination, subsequent proteasomal degradation and T cell activation. ikaros 108-114 interleukin 17 receptor B Homo sapiens 129-133 24328678-8 2014 In conclusion, we present a molecular model in which drug binding to cereblon results in the interaction of Ikaros and Aiolos to CRL4(CRBN) , leading to their ubiquitination, subsequent proteasomal degradation and T cell activation. ikaros 108-114 cereblon Homo sapiens 134-138 23977012-4 2013 We demonstrate that BTK phosphorylates Ikaros at unique phosphorylation sites S214 and S215 in the close vicinity of its zinc finger 4 (ZF4) within the DNA binding domain, thereby augmenting its nuclear localization and sequence-specific DNA binding activity. ikaros 39-45 Bruton tyrosine kinase Homo sapiens 20-23 23977012-4 2013 We demonstrate that BTK phosphorylates Ikaros at unique phosphorylation sites S214 and S215 in the close vicinity of its zinc finger 4 (ZF4) within the DNA binding domain, thereby augmenting its nuclear localization and sequence-specific DNA binding activity. ikaros 39-45 Yip1 domain family member 4 Homo sapiens 126-134 23299235-0 2013 Ikaros to the rescue of TCR-alpha chain gene rearrangement. ikaros 0-6 T cell receptor alpha constant Homo sapiens 24-33 22859015-0 2012 Ikaros inhibits proliferation and, through upregulation of Slug, increases metastatic ability of ovarian serous adenocarcinoma cells. ikaros 0-6 snail family transcriptional repressor 2 Homo sapiens 59-63 22231443-0 2012 Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer. ikaros 0-6 Spi-1 proto-oncogene Homo sapiens 31-35 22231443-0 2012 Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer. ikaros 0-6 Spi-1 proto-oncogene Homo sapiens 87-92 22231443-4 2012 Chromatin immune precipitation analysis and functional perturbations revealed that Ikaros can directly repress or activate Sfpi1 transcription via different PU.1 cis-elements, with PU.1 and Ikaros collaborating at myeloid-specific elements but not at other elements. ikaros 83-89 Spi-1 proto-oncogene Homo sapiens 123-128 22231443-4 2012 Chromatin immune precipitation analysis and functional perturbations revealed that Ikaros can directly repress or activate Sfpi1 transcription via different PU.1 cis-elements, with PU.1 and Ikaros collaborating at myeloid-specific elements but not at other elements. ikaros 83-89 Spi-1 proto-oncogene Homo sapiens 157-161 22638570-3 2012 Through promoter deletion analysis, we have mapped a distal E-box element and a proximal Ikaros site that are essential for Myh7b promoter activity in muscle cells. ikaros 89-95 myosin, heavy chain 7B, cardiac muscle, beta Mus musculus 124-129 22778136-0 2012 GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis. ikaros 16-22 GATA binding protein 1 Mus musculus 0-6 22778136-0 2012 GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis. ikaros 16-22 hes family bHLH transcription factor 1 Mus musculus 69-73 22778136-4 2012 This is also supported by the decreased primary erythroid cell differentiation upon HES1 upregulation in Ikaros-deficient mice. ikaros 105-111 hes family bHLH transcription factor 1 Mus musculus 84-88 22778136-8 2012 In aggregate, our results describe a mechanism whereby GATA-1 utilizes Ikaros and Polycomb repressive complex 2 to promote Hes1 repression as an important step in erythroid cell differentiation. ikaros 71-77 GATA binding protein 1 Mus musculus 55-61 22778136-8 2012 In aggregate, our results describe a mechanism whereby GATA-1 utilizes Ikaros and Polycomb repressive complex 2 to promote Hes1 repression as an important step in erythroid cell differentiation. ikaros 71-77 hes family bHLH transcription factor 1 Mus musculus 123-127 22684523-3 2012 We had previously shown that in anergic CD4(+) T cells, Ikaros participates in the transcriptional repression of the Il2 gene by recruiting histone deacetylases that cause core histone deacetylation at the Il2 promoter. ikaros 57-63 interleukin 2 Homo sapiens 118-121 22684523-3 2012 We had previously shown that in anergic CD4(+) T cells, Ikaros participates in the transcriptional repression of the Il2 gene by recruiting histone deacetylases that cause core histone deacetylation at the Il2 promoter. ikaros 57-63 interleukin 2 Homo sapiens 207-210 22848414-5 2012 Through chromatin immunoprecipitation and luciferase reporter assays we corroborated these findings both in vivo and in vitro, showing that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. ikaros 140-146 immunoglobulin lambda like polypeptide 1 Homo sapiens 257-262 22323189-3 2012 We confirmed that deletion of IKZF1 gene exons 4-7 is responsible for the generation of Ikaros 6 (Ik6). ikaros 88-94 IKAROS family zinc finger 1 Homo sapiens 30-35 22185780-0 2012 Bmi1 is critical to prevent Ikaros-mediated lymphoid priming in hematopoietic stem cells. ikaros 28-34 Bmi1 polycomb ring finger oncogene Mus musculus 0-4 22185780-4 2012 Selective ablation of Bmi1 in the hematopoietic system induced extensive upregulation of Ikaros and concomitant Ikaros-dependent lymphoid-lineage transcriptional priming, which is marked by their loss of H2A ubiquitination and increased H3K4 trimethylation in Bmi1-KO long-term HSCs (LT-HSCs). ikaros 89-95 Bmi1 polycomb ring finger oncogene Mus musculus 22-26 22185780-4 2012 Selective ablation of Bmi1 in the hematopoietic system induced extensive upregulation of Ikaros and concomitant Ikaros-dependent lymphoid-lineage transcriptional priming, which is marked by their loss of H2A ubiquitination and increased H3K4 trimethylation in Bmi1-KO long-term HSCs (LT-HSCs). ikaros 112-118 Bmi1 polycomb ring finger oncogene Mus musculus 22-26 22185780-5 2012 Removal of Ikaros in Bmi1-null LT-HSCs significantly diminished the hematopoietic defects seen in conditional Bmi1-KO mice. ikaros 11-17 Bmi1 polycomb ring finger oncogene Mus musculus 21-25 22185780-5 2012 Removal of Ikaros in Bmi1-null LT-HSCs significantly diminished the hematopoietic defects seen in conditional Bmi1-KO mice. ikaros 11-17 Bmi1 polycomb ring finger oncogene Mus musculus 110-114 22301782-0 2012 CtBP1 interacts with Ikaros and modulates pituitary tumor cell survival and response to hypoxia. ikaros 21-27 C-terminal binding protein 1 Homo sapiens 0-5 22301782-4 2012 Ikaros and CtBP1 expression is coordinately induced by hypoxia, and this response is abrogated by CtBP1 deficiency. ikaros 0-6 C-terminal binding protein 1 Homo sapiens 98-103 22848414-5 2012 Through chromatin immunoprecipitation and luciferase reporter assays we corroborated these findings both in vivo and in vitro, showing that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. ikaros 140-146 BLK proto-oncogene, Src family tyrosine kinase Homo sapiens 264-267 22848414-5 2012 Through chromatin immunoprecipitation and luciferase reporter assays we corroborated these findings both in vivo and in vitro, showing that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. ikaros 140-146 EBF transcription factor 1 Homo sapiens 269-273 22848414-5 2012 Through chromatin immunoprecipitation and luciferase reporter assays we corroborated these findings both in vivo and in vitro, showing that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. ikaros 140-146 mutS homolog 2 Homo sapiens 275-279 22848414-5 2012 Through chromatin immunoprecipitation and luciferase reporter assays we corroborated these findings both in vivo and in vitro, showing that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. ikaros 140-146 BUB3 mitotic checkpoint protein Homo sapiens 281-285 22848414-5 2012 Through chromatin immunoprecipitation and luciferase reporter assays we corroborated these findings both in vivo and in vitro, showing that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. ikaros 140-146 ETS variant transcription factor 6 Homo sapiens 287-291 22848414-5 2012 Through chromatin immunoprecipitation and luciferase reporter assays we corroborated these findings both in vivo and in vitro, showing that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. ikaros 140-146 YES proto-oncogene 1, Src family tyrosine kinase Homo sapiens 293-297 22848414-5 2012 Through chromatin immunoprecipitation and luciferase reporter assays we corroborated these findings both in vivo and in vitro, showing that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. ikaros 140-146 cyclin dependent kinase inhibitor 1A Homo sapiens 299-305 22848414-5 2012 Through chromatin immunoprecipitation and luciferase reporter assays we corroborated these findings both in vivo and in vitro, showing that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. ikaros 140-146 cyclin dependent kinase inhibitor 1A Homo sapiens 307-310 22848414-5 2012 Through chromatin immunoprecipitation and luciferase reporter assays we corroborated these findings both in vivo and in vitro, showing that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. ikaros 140-146 cyclin dependent kinase inhibitor 2C Homo sapiens 313-319 22848414-5 2012 Through chromatin immunoprecipitation and luciferase reporter assays we corroborated these findings both in vivo and in vitro, showing that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. ikaros 140-146 cyclin dependent kinase inhibitor 2C Homo sapiens 321-324 22848414-5 2012 Through chromatin immunoprecipitation and luciferase reporter assays we corroborated these findings both in vivo and in vitro, showing that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. ikaros 140-146 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 330-334 21765976-0 2011 Up a lymphoid blind alley: Does CALM/AF10 disturb Ikaros during leukemogenesis? ikaros 50-56 synaptosome associated protein 91 Homo sapiens 32-36 21765976-0 2011 Up a lymphoid blind alley: Does CALM/AF10 disturb Ikaros during leukemogenesis? ikaros 50-56 MLLT10 histone lysine methyltransferase DOT1L cofactor Homo sapiens 37-41 21765976-3 2011 Here we discuss the role of Ikaros as a lineage master regulator during the onset and progression of myeloid leukemias, namely CALM-AF10 positive acute myeloid leukemia and chronic myeloid leukemia. ikaros 28-34 synaptosome associated protein 91 Homo sapiens 127-131 21765976-3 2011 Here we discuss the role of Ikaros as a lineage master regulator during the onset and progression of myeloid leukemias, namely CALM-AF10 positive acute myeloid leukemia and chronic myeloid leukemia. ikaros 28-34 MLLT10 histone lysine methyltransferase DOT1L cofactor Homo sapiens 132-136 20708675-8 2010 Small interfering RNA-mediated depletion of CK2-alpha also increased Ikaros activity in acrylamide-treated cells. ikaros 69-75 casein kinase 2 alpha 2 Homo sapiens 44-53 20708675-9 2010 Overall, these data suggest that acrylamide decreases the Ikaros DNA binding activity via the CK2 pathway, resulting in a decrease of NCAM expression and provide further insight into the mechanisms underlying acrylamide actions. ikaros 58-64 neural cell adhesion molecule 1 Homo sapiens 134-138 19131787-0 2008 Differential expression of Ikaros isoforms in monozygotic twins with MLL-rearranged precursor-B acute lymphoblastic leukemia. ikaros 27-33 lysine methyltransferase 2A Homo sapiens 69-72 20207529-2 2010 Differentiation of hematopoietic stem cells to lymphoid progenitors requires Ikaros-dependent lineage priming and graded levels of PU.1, which are controlled by Ikaros and Gfi1. ikaros 77-83 growth factor independent 1 transcriptional repressor Homo sapiens 172-176 19950118-5 2010 Consistently, Ikaros(-/-) mice had fewer striatal projecting neurons and, in particular, enkephalin (ENK)-positive neurons. ikaros 14-20 preproenkephalin Mus musculus 89-99 19950118-5 2010 Consistently, Ikaros(-/-) mice had fewer striatal projecting neurons and, in particular, enkephalin (ENK)-positive neurons. ikaros 14-20 preproenkephalin Mus musculus 101-104 19950118-8 2010 However, we demonstrate that Ikaros-1 and Ebf-1 independently regulate the final determination of the two populations of striatal projection neurons of the matrix compartment, ENK- and substance P-positive neurons. ikaros 29-35 preproenkephalin Mus musculus 176-179 16873443-0 2006 Tumor-derived Ikaros 6 acetylates the Bcl-XL promoter to up-regulate a survival signal in pituitary cells. ikaros 14-20 BCL2 like 1 Homo sapiens 38-44 18483254-2 2008 Here, we show that Ikaros regulates the low-density lipoprotein receptor (LDL-R) to alter metabolism in pituitary corticotroph cells. ikaros 19-25 low density lipoprotein receptor Mus musculus 40-72 18483254-2 2008 Here, we show that Ikaros regulates the low-density lipoprotein receptor (LDL-R) to alter metabolism in pituitary corticotroph cells. ikaros 19-25 low density lipoprotein receptor Mus musculus 74-79 17980631-0 2007 Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression. ikaros 34-40 CD4 molecule Homo sapiens 110-113 17980631-2 2007 Here, we revealed the antagonistic interplay between Ikaros and its associate the chromatin remodeler Mi-2beta during T cell development, as exemplified by the regulation of Cd4 expression. ikaros 53-59 chromodomain helicase DNA binding protein 4 Homo sapiens 102-110 17980631-2 2007 Here, we revealed the antagonistic interplay between Ikaros and its associate the chromatin remodeler Mi-2beta during T cell development, as exemplified by the regulation of Cd4 expression. ikaros 53-59 CD4 molecule Homo sapiens 174-177 17980631-3 2007 Loss of Ikaros or Mi-2beta led to activation or repression, respectively, of the Cd4 locus at inappropriate stages of development. ikaros 8-14 CD4 molecule Homo sapiens 81-84 17980631-5 2007 In double-negative thymocytes, Ikaros binding to the Cd4 silencer contributed to its repressive activity. ikaros 31-37 CD4 molecule Homo sapiens 53-56 17980631-6 2007 In double-positive thymocytes, concomitant binding of Mi-2beta with Ikaros to the Cd4 silencer caused silencer inactivation, thereby allowing for CD4 expression. ikaros 68-74 chromodomain helicase DNA binding protein 4 Homo sapiens 54-62 17980631-6 2007 In double-positive thymocytes, concomitant binding of Mi-2beta with Ikaros to the Cd4 silencer caused silencer inactivation, thereby allowing for CD4 expression. ikaros 68-74 CD4 molecule Homo sapiens 82-85 17980631-6 2007 In double-positive thymocytes, concomitant binding of Mi-2beta with Ikaros to the Cd4 silencer caused silencer inactivation, thereby allowing for CD4 expression. ikaros 68-74 CD4 molecule Homo sapiens 146-149 16354692-7 2006 Furthermore, Ikaros binds to the Notch-responsive element in the Hes-1 promoter and represses Notch-dependent transcription from this promoter. ikaros 13-19 hes family bHLH transcription factor 1 Mus musculus 65-70 16354692-0 2006 Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice. ikaros 80-86 notch 1 Mus musculus 0-5 16628252-0 2006 Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE. ikaros 42-48 interleukin 4 Mus musculus 10-14 16354692-7 2006 Furthermore, Ikaros binds to the Notch-responsive element in the Hes-1 promoter and represses Notch-dependent transcription from this promoter. ikaros 13-19 notch 1 Mus musculus 33-38 16354692-8 2006 Thus, Ikaros-mediated repression of Notch target gene expression may play a critical role in defining the tumor suppressor function of this factor. ikaros 6-12 notch 1 Mus musculus 36-41 15737573-4 2005 Silencing of lambda5 expression in mature B cells occurs through the action of Ikaros on the gene promoter where it may compete for binding of EBF and initiate the formation of a silent chromatin structure. ikaros 79-85 pre-B lymphocyte gene 2 Mus musculus 13-20 15618287-3 2005 We show here that Ikaros is expressed in pituitary mammosomatotrophs where it regulates the GH and prolactin (PRL) genes. ikaros 18-24 prolactin Rattus norvegicus 99-108 15618287-3 2005 We show here that Ikaros is expressed in pituitary mammosomatotrophs where it regulates the GH and prolactin (PRL) genes. ikaros 18-24 prolactin Rattus norvegicus 110-113 15618287-7 2005 Ikaros selectively deacetylates histone 3 residues on the proximal transfected or endogenous GH promoter and limits access of the Pit1 activator. ikaros 0-6 POU class 1 homeobox 1 Rattus norvegicus 130-134 15618287-8 2005 In contrast, Ikaros acetylates histone 3 on the proximal PRL promoter and facilitates Pit1 binding to this region in the same cells. ikaros 13-19 prolactin Rattus norvegicus 57-60 15618287-8 2005 In contrast, Ikaros acetylates histone 3 on the proximal PRL promoter and facilitates Pit1 binding to this region in the same cells. ikaros 13-19 POU class 1 homeobox 1 Rattus norvegicus 86-90 15618287-9 2005 These data provide evidence for Ikaros-mediated histone acetylation and chromatin remodeling in the selective regulation of pituitary GH and PRL hormone gene expression. ikaros 32-38 prolactin Rattus norvegicus 141-144 16364975-2 2005 In addition, we have reported that Ikaros regulates the human placental leucine aminopeptidase (P-LAP)/insulin-regulated aminopeptidase (IRAP) gene in choriocarcinoma trophoblastic cells, suggesting that Ikaros might be involved in placental development, while even its presence in human placenta remains undetermined. ikaros 35-41 leucyl and cystinyl aminopeptidase Homo sapiens 62-94 16364975-2 2005 In addition, we have reported that Ikaros regulates the human placental leucine aminopeptidase (P-LAP)/insulin-regulated aminopeptidase (IRAP) gene in choriocarcinoma trophoblastic cells, suggesting that Ikaros might be involved in placental development, while even its presence in human placenta remains undetermined. ikaros 35-41 leucyl and cystinyl aminopeptidase Homo sapiens 96-102 16364975-2 2005 In addition, we have reported that Ikaros regulates the human placental leucine aminopeptidase (P-LAP)/insulin-regulated aminopeptidase (IRAP) gene in choriocarcinoma trophoblastic cells, suggesting that Ikaros might be involved in placental development, while even its presence in human placenta remains undetermined. ikaros 35-41 leucyl and cystinyl aminopeptidase Homo sapiens 103-135 16364975-2 2005 In addition, we have reported that Ikaros regulates the human placental leucine aminopeptidase (P-LAP)/insulin-regulated aminopeptidase (IRAP) gene in choriocarcinoma trophoblastic cells, suggesting that Ikaros might be involved in placental development, while even its presence in human placenta remains undetermined. ikaros 35-41 leucyl and cystinyl aminopeptidase Homo sapiens 137-141 16364975-2 2005 In addition, we have reported that Ikaros regulates the human placental leucine aminopeptidase (P-LAP)/insulin-regulated aminopeptidase (IRAP) gene in choriocarcinoma trophoblastic cells, suggesting that Ikaros might be involved in placental development, while even its presence in human placenta remains undetermined. ikaros 204-210 leucyl and cystinyl aminopeptidase Homo sapiens 62-94 16364975-2 2005 In addition, we have reported that Ikaros regulates the human placental leucine aminopeptidase (P-LAP)/insulin-regulated aminopeptidase (IRAP) gene in choriocarcinoma trophoblastic cells, suggesting that Ikaros might be involved in placental development, while even its presence in human placenta remains undetermined. ikaros 204-210 leucyl and cystinyl aminopeptidase Homo sapiens 96-102 16364975-2 2005 In addition, we have reported that Ikaros regulates the human placental leucine aminopeptidase (P-LAP)/insulin-regulated aminopeptidase (IRAP) gene in choriocarcinoma trophoblastic cells, suggesting that Ikaros might be involved in placental development, while even its presence in human placenta remains undetermined. ikaros 204-210 leucyl and cystinyl aminopeptidase Homo sapiens 103-135 16364975-2 2005 In addition, we have reported that Ikaros regulates the human placental leucine aminopeptidase (P-LAP)/insulin-regulated aminopeptidase (IRAP) gene in choriocarcinoma trophoblastic cells, suggesting that Ikaros might be involved in placental development, while even its presence in human placenta remains undetermined. ikaros 204-210 leucyl and cystinyl aminopeptidase Homo sapiens 137-141 15944284-6 2005 Mouse IL-7Ralpha promoter has striking homology with human and rat, containing consensus motifs of Ikaros, PU.1, and Runx1 transcription factors. ikaros 99-105 interleukin 7 receptor Mus musculus 6-16 15737573-4 2005 Silencing of lambda5 expression in mature B cells occurs through the action of Ikaros on the gene promoter where it may compete for binding of EBF and initiate the formation of a silent chromatin structure. ikaros 79-85 early B cell factor 1 Mus musculus 143-146 15136556-8 2004 Our results therefore delineate a new role for Ikaros family members, showing that normal levels of Ikaros proteins are essential in DC to regulate the terminal stages of maturation and the capacity to induce optimal Th1 T cell responses. ikaros 47-53 negative elongation factor complex member C/D Homo sapiens 217-220 10508239-4 1999 In accordance with Ikaros, the avian Aiolos is also highly related to the mammalian homolog, thus suggesting an evolutionarily conserved function in lymphocyte development. ikaros 19-25 IKAROS family zinc finger 3 Homo sapiens 37-43 12799380-6 2003 Analysis of the FAAH promoter showed an Ikaros binding site, and mutation of this site prevented FAAH activation by progesterone in transient expression assays. ikaros 40-46 fatty acid amide hydrolase Homo sapiens 16-20 12799380-6 2003 Analysis of the FAAH promoter showed an Ikaros binding site, and mutation of this site prevented FAAH activation by progesterone in transient expression assays. ikaros 40-46 fatty acid amide hydrolase Homo sapiens 97-101 11959865-0 2002 Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression. ikaros 0-6 RB binding protein 8, endonuclease Homo sapiens 7-11 11959865-6 2002 Consistent with this expectation, we show that Ikaros can interact with a CtBP-interacting protein (CtIP), which has also been linked to a deacetylase-independent strategy of repression. ikaros 47-53 RB binding protein 8, endonuclease Homo sapiens 74-98 11959865-6 2002 Consistent with this expectation, we show that Ikaros can interact with a CtBP-interacting protein (CtIP), which has also been linked to a deacetylase-independent strategy of repression. ikaros 47-53 RB binding protein 8, endonuclease Homo sapiens 100-104 11959865-7 2002 Despite being a CtBP interactor, CtIP"s association with Ikaros does not require CtBP but instead relies upon its Rb interaction domain. ikaros 57-63 RB binding protein 8, endonuclease Homo sapiens 33-37 11700047-6 2001 Nevertheless, the TFPT (FB1) promoter, tested by transactivation assays, was found to be responsive to Ikaros 2 and, mainly, to PU.1, a transcription factor belonging to the Ets family. ikaros 103-109 TCF3 fusion partner Homo sapiens 18-22 11700047-6 2001 Nevertheless, the TFPT (FB1) promoter, tested by transactivation assays, was found to be responsive to Ikaros 2 and, mainly, to PU.1, a transcription factor belonging to the Ets family. ikaros 103-109 TCF3 fusion partner Homo sapiens 24-27 15004008-3 2004 He e we demonstrate that ectopic Pax5 expression from the Ikaros promote induces proximal rather than distal VH-DJH rearrangements in Ik(Pax5/+) thymocytes, thus recapitulating the loss-of-function phenotype of Pax5-/- pro-B cells. ikaros 58-64 paired box 5 Homo sapiens 33-37 15032574-2 2004 Ikaros and PU.1 act in parallel pathways to control the development of lymphoid progenitors in part by regulating the expression of essential signaling receptors (Flt3, c-Kit, and IL-7R alpha). ikaros 0-6 fms related receptor tyrosine kinase 3 Homo sapiens 163-167 15032574-2 2004 Ikaros and PU.1 act in parallel pathways to control the development of lymphoid progenitors in part by regulating the expression of essential signaling receptors (Flt3, c-Kit, and IL-7R alpha). ikaros 0-6 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 169-174 15032574-2 2004 Ikaros and PU.1 act in parallel pathways to control the development of lymphoid progenitors in part by regulating the expression of essential signaling receptors (Flt3, c-Kit, and IL-7R alpha). ikaros 0-6 interleukin 7 receptor Homo sapiens 180-191 11830486-2 2002 The spliced Ikaros isoforms 4 to 8 (Ik4-8) suppress the function of full-length Ik1 or Ik2 in a dominant-negative manner, owing to their reduced numbers of DNA binding sites. ikaros 12-18 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Mus musculus 80-83 11245580-5 2001 This Kruppel-like factor, named mKlf7, binds specifically to an Ikaros core binding element that is crucial for in vivo TrkA enhancer function. ikaros 64-70 Kruppel-like factor 7 (ubiquitous) Mus musculus 32-37 11245580-5 2001 This Kruppel-like factor, named mKlf7, binds specifically to an Ikaros core binding element that is crucial for in vivo TrkA enhancer function. ikaros 64-70 neurotrophic tyrosine kinase, receptor, type 1 Mus musculus 120-124 9806640-1 1998 Aiolos encodes a zinc finger DNA-binding protein that is highly expressed in mature B cells and is homologous to Ikaros. ikaros 113-119 IKAROS family zinc finger 3 Mus musculus 0-6 9857074-1 1998 Dexamethasone inhibits binding to the Ikaros and AP-1 regulatory elements of the granzyme B promoter. ikaros 38-44 granzyme B Homo sapiens 81-91 9857074-3 1998 Granzyme B gene transcription is induced in activated lymphocytes upon antigenic stimulation, and several regulatory regions including CBF, AP-1, and Ikaros binding sites have been shown to be essential in the control of granzyme B promoter activation. ikaros 150-156 granzyme B Homo sapiens 0-10 9857074-3 1998 Granzyme B gene transcription is induced in activated lymphocytes upon antigenic stimulation, and several regulatory regions including CBF, AP-1, and Ikaros binding sites have been shown to be essential in the control of granzyme B promoter activation. ikaros 150-156 granzyme B Homo sapiens 221-231 9857074-6 1998 Mutation of Ikaros or AP-1 binding sites in the context of the granzyme B promoter demonstrated that both sites participate in dexamethasone-mediated inhibition of the granzyme B promoter activity. ikaros 12-18 granzyme B Homo sapiens 63-73 9857074-6 1998 Mutation of Ikaros or AP-1 binding sites in the context of the granzyme B promoter demonstrated that both sites participate in dexamethasone-mediated inhibition of the granzyme B promoter activity. ikaros 12-18 granzyme B Homo sapiens 168-178 7624346-5 1995 Mutational analysis of the human granzyme B promoter reveals that the Ikaros binding site (-143 to -114) and the AP-1/CBF binding site (-103 to -77) are essential for the activation of transcription in phytohemagglutinin-activated peripheral blood lymphocytes, whereas mutation of the Ets binding site does not affect promoter activity in these cells. ikaros 70-76 granzyme B Homo sapiens 33-43 8663264-4 1996 A strong DNase1 hypersensitive site that coincides with the closely associated AP-1, CBF, Ikaros, and CRE elements is present in activated CD8(+) T cells but not in resting T cells or L cells. ikaros 90-96 deoxyribonuclease I Mus musculus 9-15 32967454-7 2020 Furthermore, lenalidomide may regulate the function of CAR T cells by inducing the degradation of transcription factors Ikaros and Aiolos. ikaros 120-126 nuclear receptor subfamily 1 group I member 3 Homo sapiens 55-58 34871625-0 2022 Myeloid ikaros-SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver. ikaros 8-14 sirtuin 1 Mus musculus 15-20 34572892-6 2021 By binding to CRBN, IMiDs change the substrate specificity of the CRBN E3 ubiquitin ligase complex, which results in the breakdown of internal Ikaros and Aiolos proteins. ikaros 143-149 cereblon Homo sapiens 14-18 34572892-6 2021 By binding to CRBN, IMiDs change the substrate specificity of the CRBN E3 ubiquitin ligase complex, which results in the breakdown of internal Ikaros and Aiolos proteins. ikaros 143-149 cereblon Homo sapiens 66-70 33513189-0 2021 Correction: Ikaros antagonizes DNA binding by STAT5 in pre-B cells. ikaros 12-18 signal transducer and activator of transcription 5A Homo sapiens 46-51 34897794-5 2022 This study expands the spectrum of genetic defects associated with BDE2 and TRPS and demonstrates the pathogenicity of TRPS1 missense variants located outside both the nuclear localization signal and the GATA and Ikaros-like binding domains. ikaros 213-219 transcriptional repressor GATA binding 1 Homo sapiens 119-124 34551904-0 2021 Antitumor activity of the novel BTK inhibitor TG-1701 is associated with disruption of Ikaros signaling in patients with B-cell non-Hodgkin lymphoma. ikaros 87-93 Bruton tyrosine kinase Homo sapiens 32-35