PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32502633-3	2020	Lactobionic acid (LA) and doxorubicin (DOX) precursor (cis-aconitic anhydride-linked doxorubicin, CAD) were pre-conjugated onto the side chain of catalase (CAT), then co-assembled with chlorin e6 (Ce6) to form LA-CAT-CAD@Ce6 nanoparticles (LCC@Ce6-NPs).	CyADIC regimen	98-101	catalase	Homo sapiens	146-154
33210028-3	2021	In this study, the N-cadherin mimetic peptide (Cad) was biofunctionalized on the titanium metal surface via the acryloyl bisphosphonate (Ac-BP).	CyADIC regimen	47-50	cadherin 2	Homo sapiens	19-29
32502633-3	2020	Lactobionic acid (LA) and doxorubicin (DOX) precursor (cis-aconitic anhydride-linked doxorubicin, CAD) were pre-conjugated onto the side chain of catalase (CAT), then co-assembled with chlorin e6 (Ce6) to form LA-CAT-CAD@Ce6 nanoparticles (LCC@Ce6-NPs).	CyADIC regimen	98-101	catalase	Homo sapiens	156-159
30003090-7	2018	Sandblasting and hydrofluoric acid surface treatment led to the most durable bonds for the two types of CAD/CAM blocks in the present study.	CyADIC regimen	104-107	calmodulin 3	Homo sapiens	108-111
31498119-1	2019	BACKGROUND: The chemical properties of the oral environment have an appreciable influence on the in vivo degradation of CAD/CAM materials.	CyADIC regimen	120-123	calmodulin 3	Homo sapiens	124-127
31920055-8	2019	Listerine Zero brought about the most noticeable color change in all CAD-CAM materials except e.Max after 21 days.	CyADIC regimen	69-72	calmodulin 3	Homo sapiens	73-76
31285280-6	2019	These data reveal a previously unrecognized lysosomal P2RX4- and ADCY1-dependent signaling cascade as a pathway essential for CAD-induced lysosome-dependent cell death and encourage further investigations to find the most potent combinations of CADs and cAMP-inducing drugs for cancer therapy.	CyADIC regimen	245-249	purinergic receptor P2X 4	Homo sapiens	54-59
31285280-6	2019	These data reveal a previously unrecognized lysosomal P2RX4- and ADCY1-dependent signaling cascade as a pathway essential for CAD-induced lysosome-dependent cell death and encourage further investigations to find the most potent combinations of CADs and cAMP-inducing drugs for cancer therapy.	CyADIC regimen	245-249	adenylate cyclase 1	Homo sapiens	65-70
30849010-16	2019	For CAD/CAM resin composite materials, crack paths through the matrix and interfaces of matrix and fillers could be observed at the microstructure level.	CyADIC regimen	4-7	calmodulin 3	Homo sapiens	8-11
29310879-17	2018	AE, AP, Z, MAT, and BS CAD-CAM polymers and injection-molded acrylic resin had similar load-to-fracture values, which were higher than those of BG and autopolymerized acrylic resin.	CyADIC regimen	23-26	calmodulin 3	Homo sapiens	27-30
28967392-0	2018	CAD-CAM high-density polymer implant-supported fixed diagnostic prostheses.	CyADIC regimen	0-3	calmodulin 3	Homo sapiens	4-7
29557300-3	2018	Methods The PAPA-CAD study, a 6-month open-label, prospective, multicenter, observational/non-interventional survey evaluated data accumulated from patients with hypertensive patients with stable coronary artery disease.	CyADIC regimen	17-20	pappalysin 1	Homo sapiens	12-16
26948082-4	2016	Three groups (n=19) were assessed: group ZR, CAD-CAM zirconia/Ti-6Al-4V bonded abutments; group RC, CAD-CAM resin-based composite/Ti-6Al-4V bonded abutments; and group LD, CAD-CAM lithium disilicate/Ti-6Al-4V bonded abutments.	CyADIC regimen	45-48	calmodulin 3	Homo sapiens	49-52
27456684-10	2017	The new CAD/CAM blocks (Vita Enamic, Vita Hybrid Ceramic and Lava Ultimate) showed the highest resistance to staining compared to the MZ100 composite resin blocks.	CyADIC regimen	8-11	calmodulin 3	Homo sapiens	12-15
28057347-4	2017	In this study, the ultra-structure of composite CAD-CAM blocks was investigated with special attention to the effect of sandblasting on the surface topography and of silanization on the bonding performance.	CyADIC regimen	48-51	calmodulin 3	Homo sapiens	52-55
28057347-13	2017	SIGNIFICANCE: Sandblasting followed by silanization improved the bond strength to composite CAD-CAM blocks.	CyADIC regimen	92-95	calmodulin 3	Homo sapiens	96-99
26921152-0	2016	Transmission of light in the visible spectrum (400-700 nm) and blue spectrum (360-540 nm) through CAD/CAM polymers.	CyADIC regimen	98-101	calmodulin 3	Homo sapiens	102-105
12388473-10	2003	Conversely, CaD phosphorylation, through an ERK1/2-mediated signaling pathway, as well as an increase in basal LC20-P, is suggested to contribute to the reversal of inhibition and promote contraction of the uterus during labor.	CyADIC regimen	12-15	mitogen activated protein kinase 3	Rattus norvegicus	44-50
26138675-4	2015	CAD binds to two sites in Orai1, one in the N terminal and one in the C terminal.	CyADIC regimen	0-3	ORAI calcium release-activated calcium modulator 1	Homo sapiens	26-31
24471243-2	2013	CAD/CAM units have been available to dentists since the late "80s.	CyADIC regimen	0-3	calmodulin 3	Homo sapiens	4-7
22392526-6	2012	Furthermore, both the CaDK1 and CaDK2 groups had a significantly lower mean serum undercarboxylated osteocalcin to osteocalcin ratio and urine deoxypyridinoline levels at follow-up compared to the CaD and CG groups (P = 0.001 and P = 0.047, respectively).	CyADIC regimen	22-25	bone gamma-carboxyglutamate protein	Homo sapiens	100-111
22392526-6	2012	Furthermore, both the CaDK1 and CaDK2 groups had a significantly lower mean serum undercarboxylated osteocalcin to osteocalcin ratio and urine deoxypyridinoline levels at follow-up compared to the CaD and CG groups (P = 0.001 and P = 0.047, respectively).	CyADIC regimen	22-25	bone gamma-carboxyglutamate protein	Homo sapiens	115-126
22016808-10	2011	Furthermore, direct application of either 6-OHDA or MPP+ (1-methyl-4-phenylpyridinum) to CAD (CNS-derived catecholinaminergic neuronal cell line) cell cultures, reduced TID1 expression levels.Our results suggest that changes in cellular TID1 are a factor in the pathogenesis of PD by impeding functional and structural compensation and exaggerating neurodegenerative processes.	CyADIC regimen	89-92	DnaJ heat shock protein family (Hsp40) member A3	Rattus norvegicus	169-173
21677770-5	2011	When delivered intra-arterially into the ischemic hindlimbs of ApoE-/- mice, CD34+/M-cad+ BMCs alleviated ischemia and significantly improved blood flow compared with CD34+/M-cad- BMCs, CD34-/M-cad+ BMCs, or unselected BMCs.	CyADIC regimen	85-88	apolipoprotein E	Mus musculus	63-67
21677770-5	2011	When delivered intra-arterially into the ischemic hindlimbs of ApoE-/- mice, CD34+/M-cad+ BMCs alleviated ischemia and significantly improved blood flow compared with CD34+/M-cad- BMCs, CD34-/M-cad+ BMCs, or unselected BMCs.	CyADIC regimen	85-88	CD34 antigen	Mus musculus	77-81
18001595-5	2007	RESULTS: The surgical simulation on the model produced by CAD/CAM technique highly resembled the real operation.	CyADIC regimen	58-61	calmodulin 3	Homo sapiens	62-65
27222889-8	2016	RESULTS: The bonding performance of the six CAD/CAM materials was significantly influenced by surface treatment (linear mixed models, p < 0.05).	CyADIC regimen	44-47	calmodulin 3	Homo sapiens	48-51
23964776-9	2013	After cyclic loading, the CAD/CAM group recorded the highest marginal gap mean value (91.50 +- 4.260 mum) followed by control group (72.00 +- 2.795 mum); the Zirkonzahn group recorded the lowest marginal gap (65.37 +- 6.138 mum).	CyADIC regimen	26-29	calmodulin 3	Homo sapiens	30-33
21925214-2	2011	HIF-1alpha induces the expressions of numerous hypoxia-induced genes through two transactivation domains; N-terminal TAD (NAD) and C-terminal TAD (CAD).	CyADIC regimen	147-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
20181812-3	2010	OBJECTIVE: The objective was to evaluate the effect of a longer-term effect (over 5 y) of calcium and vitamin D (CaD) supplementation on changes in the concentrations of several lipids: LDL, HDL, non-HDL, total cholesterol, triglycerides, and lipoprotein(a) [Lp(a)].	CyADIC regimen	113-116	lipoprotein(a)	Homo sapiens	243-257
20181812-3	2010	OBJECTIVE: The objective was to evaluate the effect of a longer-term effect (over 5 y) of calcium and vitamin D (CaD) supplementation on changes in the concentrations of several lipids: LDL, HDL, non-HDL, total cholesterol, triglycerides, and lipoprotein(a) [Lp(a)].	CyADIC regimen	113-116	lipoprotein(a)	Homo sapiens	259-264
15761204-5	2005	RESULTS: CRP was elevated above control levels (0.54 [0.33 to 0.84] median, interquartile range mg/L) in patients with LAA (2.59 [0.56 to 3.99] mg/L; P<0.001) and with CAD (2.37 [0.57 to 4.78] mg/L; P=0.0013) but not in patients with cryptogenic etiology (0.74 [0.14 to 7.86] mg/L).	CyADIC regimen	171-174	C-reactive protein	Homo sapiens	9-12
12027147-7	2002	RESULTS: A significant difference was observed between the calcium-vitamin D (CaD) and the calcium (Ca) only groups for changes occurring during the 90 days of the study in PTH (-14.5+/-40% and +2.5+/-46%) (p=0.009) and 25(OH)D (+67+/-77% and +18+/-55%) (p<0.001) circulating levels.	CyADIC regimen	78-81	parathyroid hormone	Homo sapiens	173-176
10872995-10	2000	It can be concluded that the CAD/CAM inlays processed of the two ceramics functioned well during the 8-yr follow-up period.	CyADIC regimen	29-32	calmodulin 3	Homo sapiens	33-36
8883121-11	1996	PTH decreased on Ca + D and returned to baseline after treatment, and 25-hydroxyvitamin D increased with treatment and remained elevated 6 weeks after the end of treatment.	CyADIC regimen	17-23	parathyroid hormone	Homo sapiens	0-3
10202154-6	1999	In the mammalian two-hybrid system, CAD and NAD baits enhanced the luciferase expression from a reporter gene by co-transfection with CREB-binding protein (CBP) prey, whereas CAD, but not NAD, enhanced beta-galactosidase expression in yeast by CBP co-expression, suggesting that NAD and CAD interact with CBP/p300 by a different mechanism.	CyADIC regimen	36-39	CREB binding protein	Homo sapiens	134-154
10202154-6	1999	In the mammalian two-hybrid system, CAD and NAD baits enhanced the luciferase expression from a reporter gene by co-transfection with CREB-binding protein (CBP) prey, whereas CAD, but not NAD, enhanced beta-galactosidase expression in yeast by CBP co-expression, suggesting that NAD and CAD interact with CBP/p300 by a different mechanism.	CyADIC regimen	36-39	CREB binding protein	Homo sapiens	156-159
10202154-6	1999	In the mammalian two-hybrid system, CAD and NAD baits enhanced the luciferase expression from a reporter gene by co-transfection with CREB-binding protein (CBP) prey, whereas CAD, but not NAD, enhanced beta-galactosidase expression in yeast by CBP co-expression, suggesting that NAD and CAD interact with CBP/p300 by a different mechanism.	CyADIC regimen	36-39	galactosidase beta 1	Homo sapiens	202-220
10202154-6	1999	In the mammalian two-hybrid system, CAD and NAD baits enhanced the luciferase expression from a reporter gene by co-transfection with CREB-binding protein (CBP) prey, whereas CAD, but not NAD, enhanced beta-galactosidase expression in yeast by CBP co-expression, suggesting that NAD and CAD interact with CBP/p300 by a different mechanism.	CyADIC regimen	36-39	CREB binding protein	Homo sapiens	244-247
10202154-6	1999	In the mammalian two-hybrid system, CAD and NAD baits enhanced the luciferase expression from a reporter gene by co-transfection with CREB-binding protein (CBP) prey, whereas CAD, but not NAD, enhanced beta-galactosidase expression in yeast by CBP co-expression, suggesting that NAD and CAD interact with CBP/p300 by a different mechanism.	CyADIC regimen	36-39	CREB binding protein	Homo sapiens	244-247
10202154-6	1999	In the mammalian two-hybrid system, CAD and NAD baits enhanced the luciferase expression from a reporter gene by co-transfection with CREB-binding protein (CBP) prey, whereas CAD, but not NAD, enhanced beta-galactosidase expression in yeast by CBP co-expression, suggesting that NAD and CAD interact with CBP/p300 by a different mechanism.	CyADIC regimen	36-39	E1A binding protein p300	Homo sapiens	309-313
10202154-8	1999	Amino acid replacement in the sequences of CADs revealed a specific cysteine to be essential for their hypoxia-inducible interaction with CBP.	CyADIC regimen	43-47	CREB binding protein	Homo sapiens	138-141
9524782-1	1998	The calcium-PTH relationship in uremic patients has been often studied during dialysis sessions with high or low dialysate calcium concentration (CaD).	CyADIC regimen	146-149	parathyroid hormone	Homo sapiens	12-15
9505250-7	1998	Theoretical changes in volume of 2.6% and 0.8% are possible to detect with these CAD/CAM systems.	CyADIC regimen	81-84	calmodulin 3	Homo sapiens	85-88
8883121-12	1996	We conclude that Ca + D reduces bone resorption in older women, possibly by suppressing PTH levels.	CyADIC regimen	17-23	parathyroid hormone	Homo sapiens	88-91
34272634-0	2022	Effect of sandblasting and/or priming treatment on the shear bond strength of self-adhesive resin cement to CAD/CAM blocks.	CyADIC regimen	108-111	calmodulin 3	Homo sapiens	112-115
1515698-5	1992	Both DPP I and DPP II activities increased after 3 weeks of CAD or CHO treatment.	CyADIC regimen	60-63	cathepsin C	Rattus norvegicus	5-10
1515698-5	1992	Both DPP I and DPP II activities increased after 3 weeks of CAD or CHO treatment.	CyADIC regimen	60-63	dipeptidylpeptidase 7	Rattus norvegicus	15-21
34506118-8	2021	An excellent therapeutic effect is achieved when the immune checkpoint PD-1 antibody (aPD-1) is utilized to cooperate with the PEG/PEI/CAD NPs for blocking tumor immune escape and maintaining antitumor activity of the ICD-instigated T cells.	CyADIC regimen	135-138	programmed cell death 1	Homo sapiens	71-75
33689218-3	2021	Then, doxorubicin-cis-aconitic anhydride (CAD) and BCl2-shRNA (as a therapeutic gene) are coloaded into the PEI-co-PPhe carrier to form PEI-co-PPhe/Bcl2-shRNA/CAD complexes as a codeliver system.	CyADIC regimen	42-45	B cell leukemia/lymphoma 2	Mus musculus	148-152