PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22337809-3	2012	Here, we showed that the TLR4 agonist and vaccine adjuvant CRX-547, a member of the aminoalkyl glucosaminide 4-phosphate (AGP) class of synthetic lipid A mimetics, displayed TRIF-selective signaling in human cells, which was dependent on a minor structural modification to the carboxyl bioisostere corresponding to the 1-phosphate group on most lipid A types.	agp	122-125	toll like receptor 4	Homo sapiens	25-29
25553892-0	2015	Characterization of TRIF selectivity in the AGP class of lipid A mimetics: role of secondary lipid chains.	agp	44-47	TIR domain containing adaptor molecule 1	Homo sapiens	20-24
25173814-3	2014	Generation of ROS is involved in the AGP-induced cancer cell death of several colorectal cancer cells (Caco2, HCT116 and SW480) by activation of ASK1-mediated apoptosis signaling pathway without affecting control cells (human colonic sub-epithelial myofibroblasts; CO18, human fetal lung fibroblast; MRC5 and fetal human colon; FHC).	agp	37-40	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	145-149
25173814-3	2014	Generation of ROS is involved in the AGP-induced cancer cell death of several colorectal cancer cells (Caco2, HCT116 and SW480) by activation of ASK1-mediated apoptosis signaling pathway without affecting control cells (human colonic sub-epithelial myofibroblasts; CO18, human fetal lung fibroblast; MRC5 and fetal human colon; FHC).	agp	37-40	low density lipoprotein receptor	Homo sapiens	328-331
25173814-10	2014	This indicates that in HT29 cells, Nrf2/Srx axis is a protective factor against AGP-induced oxidative stress.	agp	80-83	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
25173814-10	2014	This indicates that in HT29 cells, Nrf2/Srx axis is a protective factor against AGP-induced oxidative stress.	agp	80-83	sulfiredoxin 1	Homo sapiens	40-43
22337809-3	2012	Here, we showed that the TLR4 agonist and vaccine adjuvant CRX-547, a member of the aminoalkyl glucosaminide 4-phosphate (AGP) class of synthetic lipid A mimetics, displayed TRIF-selective signaling in human cells, which was dependent on a minor structural modification to the carboxyl bioisostere corresponding to the 1-phosphate group on most lipid A types.	agp	122-125	TIR domain containing adaptor molecule 1	Homo sapiens	174-178
20450371-5	2010	RESULTS: Subjects who presented generalized AgP have a higher frequency of hypomethylation of the IL8 gene promoter in oral epithelium cells than that of controls (86.5% in the generalized AgP group versus 62% in the control group; P = 0.016; chi(2) test).	agp	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	98-101
18490759-2	2008	Because F. tularensis LPS causes weak TLR4 activation, we hypothesized that administration of a synthetic TLR4 agonist, aminoalkyl glucosaminide phosphate (AGP), would boost the innate immune system and compensate for reduced TLR4 stimulation.	agp	156-159	toll-like receptor 4	Mus musculus	38-42
18490759-2	2008	Because F. tularensis LPS causes weak TLR4 activation, we hypothesized that administration of a synthetic TLR4 agonist, aminoalkyl glucosaminide phosphate (AGP), would boost the innate immune system and compensate for reduced TLR4 stimulation.	agp	156-159	toll-like receptor 4	Mus musculus	106-110
18490759-2	2008	Because F. tularensis LPS causes weak TLR4 activation, we hypothesized that administration of a synthetic TLR4 agonist, aminoalkyl glucosaminide phosphate (AGP), would boost the innate immune system and compensate for reduced TLR4 stimulation.	agp	156-159	toll-like receptor 4	Mus musculus	106-110
18490759-4	2008	Mice treated with AGPs before and after inhalation of Francisella novicida exhibited augmented cytokine and inflammatory responses to infection; reduced bacterial replication in lung, liver, and spleen; and increased survival, whereas all PBS-treated control mice died within 4 days of infection, all AGP-treated mice showed prolonged time-to-death, and 30-60% of AGP-treated mice survived.	agp	301-304	alkylglycerone phosphate synthase	Mus musculus	18-22
16321982-1	2006	Here we showed that a naturally occurring ether analog of lysophosphatidic acid, 1-O-octadecenyl-2-hydroxy-sn-glycero-3-phosphate (AGP), is a high affinity partial agonist of the peroxisome proliferator-activated receptor gamma (PPARgamma).	agp	131-134	peroxisome proliferator activated receptor gamma	Homo sapiens	179-227
16321982-1	2006	Here we showed that a naturally occurring ether analog of lysophosphatidic acid, 1-O-octadecenyl-2-hydroxy-sn-glycero-3-phosphate (AGP), is a high affinity partial agonist of the peroxisome proliferator-activated receptor gamma (PPARgamma).	agp	131-134	peroxisome proliferator activated receptor gamma	Homo sapiens	229-238
16321982-2	2006	Binding studies using the PPARgamma ligand binding domain showed that [32P]AGP and [3H]rosiglitazone (Rosi) both specifically bind to PPARgamma and compete with each other.	agp	75-78	peroxisome proliferator activated receptor gamma	Homo sapiens	26-35
16321982-2	2006	Binding studies using the PPARgamma ligand binding domain showed that [32P]AGP and [3H]rosiglitazone (Rosi) both specifically bind to PPARgamma and compete with each other.	agp	75-78	peroxisome proliferator activated receptor gamma	Homo sapiens	134-143
16321982-3	2006	[32P]AGP bound PPARgamma with an affinity (Kdapp 60 nm) similar to that of Rosi.	agp	5-8	peroxisome proliferator activated receptor gamma	Homo sapiens	15-24
7795416-6	1995	Preincubation of rgp160 with AGP or mannan significantly reduced its binding to monocyte-derived macrophages (MDM), suggesting that AGP may play a role in preventing binding of soluble or virus-bound Env glycoprotein to CD4+ monocytic cells.	agp	29-32	endogenous retrovirus group K member 20	Homo sapiens	200-203
7795416-6	1995	Preincubation of rgp160 with AGP or mannan significantly reduced its binding to monocyte-derived macrophages (MDM), suggesting that AGP may play a role in preventing binding of soluble or virus-bound Env glycoprotein to CD4+ monocytic cells.	agp	29-32	CD4 molecule	Homo sapiens	220-223
33519778-11	2020	However, AGP supplementation had the higher mRNA expression of Claudin-2, lower goblet cell density of jejunum, and decreased Firmicutes to Bacteroidetes ratio, suggesting that AGP might have a negative impact on intestinal immune and microbiota homeostasis.	agp	9-12	claudin 2	Homo sapiens	63-72
7537107-2	1994	In the present study, monoclonal antibodies against human gp80 interleukin-6 receptor (IL-6R) were utilized to study the role of the IL-6R in the control of the IL-6-induced AGP synthesis in the human hepatoma Hep3B cell line.	agp	174-177	interleukin 6 receptor	Homo sapiens	58-62
7537107-2	1994	In the present study, monoclonal antibodies against human gp80 interleukin-6 receptor (IL-6R) were utilized to study the role of the IL-6R in the control of the IL-6-induced AGP synthesis in the human hepatoma Hep3B cell line.	agp	174-177	interleukin 6 receptor	Homo sapiens	87-92
7537107-2	1994	In the present study, monoclonal antibodies against human gp80 interleukin-6 receptor (IL-6R) were utilized to study the role of the IL-6R in the control of the IL-6-induced AGP synthesis in the human hepatoma Hep3B cell line.	agp	174-177	interleukin 6 receptor	Homo sapiens	133-138
7537107-2	1994	In the present study, monoclonal antibodies against human gp80 interleukin-6 receptor (IL-6R) were utilized to study the role of the IL-6R in the control of the IL-6-induced AGP synthesis in the human hepatoma Hep3B cell line.	agp	174-177	interleukin 6	Homo sapiens	87-91
1280338-7	1992	Quantitative analysis of Ac-P (AGP) and total protein levels in CSF showed a partial interdependence.	agp	31-34	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	25-29
33518154-7	2021	The functional analysis showed reduced activity of genes related to signaling by interleukins, with IL-22, SOCS3, and certain antimicrobial peptides found multiple times in these pathways in the AGP group at day 35.	agp	195-198	interleukin 22	Gallus gallus	100-105
33518154-7	2021	The functional analysis showed reduced activity of genes related to signaling by interleukins, with IL-22, SOCS3, and certain antimicrobial peptides found multiple times in these pathways in the AGP group at day 35.	agp	195-198	suppressor of cytokine signaling 3	Gallus gallus	107-112
31426877-9	2020	The AGP group had higher (P < 0.05) VH and lower (P < 0.05) IL-6 gene expression in the jejunum compared with CC group.	agp	4-7	interleukin 6	Sus scrofa	60-64
29990859-1	2018	We previously showed that an alkyl-ether analog of lysophosphatidic acid, AGP (alkyl-glycerophosphate), accumulates in human atherosclerotic plaques and is a potent agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma).	agp	74-77	peroxisome proliferator activated receptor gamma	Homo sapiens	176-224
29990859-1	2018	We previously showed that an alkyl-ether analog of lysophosphatidic acid, AGP (alkyl-glycerophosphate), accumulates in human atherosclerotic plaques and is a potent agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma).	agp	74-77	peroxisome proliferator activated receptor gamma	Homo sapiens	226-235
29990859-2	2018	On the other hand, cyclic phosphatidic acid (cPA), similar in structure to AGP, can negatively regulate PPARgamma.	agp	75-78	peroxisome proliferator activated receptor gamma	Homo sapiens	104-113
29990859-5	2018	Furthermore, oxidative stress plays a major role in the pathology of cardiovascular diseases; we showed that AGP triggers ROS generation and lipid peroxidation and that ROS and 8-isoprostane generation can be suppressed by a PPARgamma antagonist.	agp	109-112	peroxisome proliferator activated receptor gamma	Homo sapiens	225-234
29355589-1	2018	Alkyl-glycerophosphate (AGP) accumulates in atherogenic oxidized-LDL and human atherosclerotic plaques and is a potent agonist of peroxisome-proliferator-activated receptor-gamma (PPARgamma).	agp	24-27	peroxisome proliferator activated receptor gamma	Homo sapiens	130-178
29355589-1	2018	Alkyl-glycerophosphate (AGP) accumulates in atherogenic oxidized-LDL and human atherosclerotic plaques and is a potent agonist of peroxisome-proliferator-activated receptor-gamma (PPARgamma).	agp	24-27	peroxisome proliferator activated receptor gamma	Homo sapiens	180-189