PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 20923787-0 2011 Therapeutic modulation of cerebral L-lysine metabolism in a mouse model for glutaric aciduria type I. Glutaric aciduria type I, an inherited deficiency of glutaryl-coenzyme A dehydrogenase localized in the final common catabolic pathway of L-lysine, L-hydroxylysine and L-tryptophan, leads to accumulation of neurotoxic glutaric and 3-hydroxyglutaric acid, as well as non-toxic glutarylcarnitine. glutarylcarnitine 378-395 glutaryl-Coenzyme A dehydrogenase Mus musculus 155-188 33483254-7 2021 We found that GA1 mice with SUGCT deficiency have decreased excretion of urine 3-hydroxyglutaric acid and decreased levels glutarylcarnitine in urine, plasma and kidney. glutarylcarnitine 123-140 succinyl-CoA glutarate-CoA transferase Mus musculus 28-33 32567100-3 2020 We show that loss of AASS function in GCDH-deficient HEK-293 cells leads to a ~ 5-fold reduction in the established GA1 clinical biomarker glutarylcarnitine. glutarylcarnitine 139-156 aminoadipate-semialdehyde synthase Homo sapiens 21-25 32567100-3 2020 We show that loss of AASS function in GCDH-deficient HEK-293 cells leads to a ~ 5-fold reduction in the established GA1 clinical biomarker glutarylcarnitine. glutarylcarnitine 139-156 glutaryl-CoA dehydrogenase Homo sapiens 38-42 32160276-3 2020 Here we show that loss of DHTKD1 in GCDH-deficient HEK-293 cells leads to a 2-fold decrease in the established GA1 clinical biomarker glutarylcarnitine, and demonstrate that OGDH is responsible for this remaining glutarylcarnitine production. glutarylcarnitine 134-151 dehydrogenase E1 and transketolase domain containing 1 Homo sapiens 26-32 32160276-3 2020 Here we show that loss of DHTKD1 in GCDH-deficient HEK-293 cells leads to a 2-fold decrease in the established GA1 clinical biomarker glutarylcarnitine, and demonstrate that OGDH is responsible for this remaining glutarylcarnitine production. glutarylcarnitine 134-151 glutaryl-CoA dehydrogenase Homo sapiens 36-40 32160276-3 2020 Here we show that loss of DHTKD1 in GCDH-deficient HEK-293 cells leads to a 2-fold decrease in the established GA1 clinical biomarker glutarylcarnitine, and demonstrate that OGDH is responsible for this remaining glutarylcarnitine production. glutarylcarnitine 213-230 dehydrogenase E1 and transketolase domain containing 1 Homo sapiens 26-32 32160276-3 2020 Here we show that loss of DHTKD1 in GCDH-deficient HEK-293 cells leads to a 2-fold decrease in the established GA1 clinical biomarker glutarylcarnitine, and demonstrate that OGDH is responsible for this remaining glutarylcarnitine production. glutarylcarnitine 213-230 glutaryl-CoA dehydrogenase Homo sapiens 36-40 32160276-3 2020 Here we show that loss of DHTKD1 in GCDH-deficient HEK-293 cells leads to a 2-fold decrease in the established GA1 clinical biomarker glutarylcarnitine, and demonstrate that OGDH is responsible for this remaining glutarylcarnitine production. glutarylcarnitine 213-230 oxoglutarate dehydrogenase Homo sapiens 174-178 28545977-2 2017 GCDH deficiency leads to disruption of l-lysine degradation with characteristic accumulation of glutarylcarnitine and neurotoxic glutaric acid (GA), glutaryl-CoA, 3-hydroxyglutaric acid (3-OHGA). glutarylcarnitine 96-113 glutaryl-Coenzyme A dehydrogenase Mus musculus 0-4 22464876-10 2012 Acylcarnitines such as glutarylcarnitine were associated inversely with eGFR (-3.73 mL/min/1.73 m(2) per standard deviation [SD] increase, pooled P = 1.8 x 10(-69)). glutarylcarnitine 23-40 epidermal growth factor receptor Homo sapiens 72-76 22464876-10 2012 Acylcarnitines such as glutarylcarnitine were associated inversely with eGFR (-3.73 mL/min/1.73 m(2) per standard deviation [SD] increase, pooled P = 1.8 x 10(-69)). glutarylcarnitine 23-40 CD59 molecule (CD59 blood group) Homo sapiens 87-92