PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33456518-0	2021	Inhibitory effect of isomorellin on cholangiocarcinoma cells via suppression of NF-kappaB translocation, the phosphorylated p38 MAPK pathway and MMP-2 and uPA expression.	isomorellin	21-32	nuclear factor kappa B subunit 1	Homo sapiens	80-89
33456518-0	2021	Inhibitory effect of isomorellin on cholangiocarcinoma cells via suppression of NF-kappaB translocation, the phosphorylated p38 MAPK pathway and MMP-2 and uPA expression.	isomorellin	21-32	matrix metallopeptidase 2	Homo sapiens	145-150
33456518-0	2021	Inhibitory effect of isomorellin on cholangiocarcinoma cells via suppression of NF-kappaB translocation, the phosphorylated p38 MAPK pathway and MMP-2 and uPA expression.	isomorellin	21-32	plasminogen activator, urokinase	Homo sapiens	155-158
33456518-12	2021	In addition, isomorellin significantly inhibited cancer cell migration and invasion abilities via focal adhesion kinase (FAK), protein kinase C (PKC), the phosphorylated (p)-p38 mitogen-activated protein kinase (MAPK) pathway, and nuclear factor (NF)-kappaB expression and translocation to the nucleus, thus resulting in downregulation of MMP-2, uPA and cyclooxygenase-2 (COX-2) expression.	isomorellin	13-24	protein tyrosine kinase 2	Homo sapiens	98-119
33456518-12	2021	In addition, isomorellin significantly inhibited cancer cell migration and invasion abilities via focal adhesion kinase (FAK), protein kinase C (PKC), the phosphorylated (p)-p38 mitogen-activated protein kinase (MAPK) pathway, and nuclear factor (NF)-kappaB expression and translocation to the nucleus, thus resulting in downregulation of MMP-2, uPA and cyclooxygenase-2 (COX-2) expression.	isomorellin	13-24	protein tyrosine kinase 2	Homo sapiens	121-124
33456518-12	2021	In addition, isomorellin significantly inhibited cancer cell migration and invasion abilities via focal adhesion kinase (FAK), protein kinase C (PKC), the phosphorylated (p)-p38 mitogen-activated protein kinase (MAPK) pathway, and nuclear factor (NF)-kappaB expression and translocation to the nucleus, thus resulting in downregulation of MMP-2, uPA and cyclooxygenase-2 (COX-2) expression.	isomorellin	13-24	mitogen-activated protein kinase 14	Homo sapiens	174-217
33456518-12	2021	In addition, isomorellin significantly inhibited cancer cell migration and invasion abilities via focal adhesion kinase (FAK), protein kinase C (PKC), the phosphorylated (p)-p38 mitogen-activated protein kinase (MAPK) pathway, and nuclear factor (NF)-kappaB expression and translocation to the nucleus, thus resulting in downregulation of MMP-2, uPA and cyclooxygenase-2 (COX-2) expression.	isomorellin	13-24	matrix metallopeptidase 2	Homo sapiens	339-344
33456518-12	2021	In addition, isomorellin significantly inhibited cancer cell migration and invasion abilities via focal adhesion kinase (FAK), protein kinase C (PKC), the phosphorylated (p)-p38 mitogen-activated protein kinase (MAPK) pathway, and nuclear factor (NF)-kappaB expression and translocation to the nucleus, thus resulting in downregulation of MMP-2, uPA and cyclooxygenase-2 (COX-2) expression.	isomorellin	13-24	plasminogen activator, urokinase	Homo sapiens	346-349
33456518-12	2021	In addition, isomorellin significantly inhibited cancer cell migration and invasion abilities via focal adhesion kinase (FAK), protein kinase C (PKC), the phosphorylated (p)-p38 mitogen-activated protein kinase (MAPK) pathway, and nuclear factor (NF)-kappaB expression and translocation to the nucleus, thus resulting in downregulation of MMP-2, uPA and cyclooxygenase-2 (COX-2) expression.	isomorellin	13-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	354-370
33456518-12	2021	In addition, isomorellin significantly inhibited cancer cell migration and invasion abilities via focal adhesion kinase (FAK), protein kinase C (PKC), the phosphorylated (p)-p38 mitogen-activated protein kinase (MAPK) pathway, and nuclear factor (NF)-kappaB expression and translocation to the nucleus, thus resulting in downregulation of MMP-2, uPA and cyclooxygenase-2 (COX-2) expression.	isomorellin	13-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	372-377
33456518-14	2021	These data demonstrated for the first time that the suppression of KKU-100 cell viability, invasion and migration, and downregulation of NF-kappaB, MMP-2, uPA and the p-p38 MAPK pathway, may result in isomorellin-mediated anti-invasiveness.	isomorellin	201-212	nuclear factor kappa B subunit 1	Homo sapiens	137-146
33456518-14	2021	These data demonstrated for the first time that the suppression of KKU-100 cell viability, invasion and migration, and downregulation of NF-kappaB, MMP-2, uPA and the p-p38 MAPK pathway, may result in isomorellin-mediated anti-invasiveness.	isomorellin	201-212	matrix metallopeptidase 2	Homo sapiens	148-153
33456518-14	2021	These data demonstrated for the first time that the suppression of KKU-100 cell viability, invasion and migration, and downregulation of NF-kappaB, MMP-2, uPA and the p-p38 MAPK pathway, may result in isomorellin-mediated anti-invasiveness.	isomorellin	201-212	plasminogen activator, urokinase	Homo sapiens	155-158
22972485-0	2012	Involvement of p53 and nuclear factor-kappaB signaling pathway for the induction of G1-phase cell cycle arrest of cholangiocarcinoma cell lines by isomorellin.	isomorellin	147-158	tumor protein p53	Homo sapiens	15-18
22972485-6	2012	Our research suggests that isomorellin induces cell cycle arrest and apoptosis in CCA cell lines through p53 and the NF-kappaB-signaling pathway.	isomorellin	27-38	tumor protein p53	Homo sapiens	105-108
22972485-6	2012	Our research suggests that isomorellin induces cell cycle arrest and apoptosis in CCA cell lines through p53 and the NF-kappaB-signaling pathway.	isomorellin	27-38	nuclear factor kappa B subunit 1	Homo sapiens	117-126