PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31942947-9	2021	The differences in GMR (90%CI) of TFV AUC, C24, and EFV C24 at week 5 versus week 8 were 0.86 (0.80-0.93), p=0.002; 0.83 (0.75-0.93), p=0.006; and EFV C24 was 0.91 (0.85-0.97), p=0.02, respectively.	tfv	34-37	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	19-22
31749296-2	2020	TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by OAT1 and OAT3.	tfv	20-29	solute carrier family 22 member 6	Homo sapiens	107-111
31560741-12	2020	CONCLUSIONS: Switch to E/C/F/TAF was associated with reductions in TFV concentrations in CSF but stable EVG concentrations that exceeded the IC50 for wild-type HIV, suggesting that EVG achieves therapeutic concentrations in the central nervous system.	tfv	67-70	TATA-box binding protein associated factor 8	Homo sapiens	29-32
31672838-1	2020	OBJECTIVE: The use of tenofovir (TDF) and entecavir (ETV) in patients with chronic hepatitis B (CHB) has led to a decrease in the incidence of hepatocellular carcinoma (HCC) and liver-related events.	tfv	22-31	sex determining region Y	Homo sapiens	33-36
31619748-1	2020	Tenofovir disoproxyl fumarate (TDF) has been associated with renal tubular abnormalities, phosphaturia and proteinuria (retinol binding protein, RBP, loss): vitamin D (VD) and PTH affect these markers.	tfv	0-29	retinol binding protein 4	Homo sapiens	145-148
31619748-1	2020	Tenofovir disoproxyl fumarate (TDF) has been associated with renal tubular abnormalities, phosphaturia and proteinuria (retinol binding protein, RBP, loss): vitamin D (VD) and PTH affect these markers.	tfv	31-34	retinol binding protein 4	Homo sapiens	145-148
31705783-1	2020	Tenofovir (TDF) imposes a high genetic barrier to drug resistance, only sporadic TDF-resistant HBV mutant was reported.	tfv	0-9	sex determining region Y	Homo sapiens	11-14
31850932-0	2020	Tenofovir for the Prevention of HCC in Patients With Cirrhosis.	tfv	0-9	HCC	Homo sapiens	32-35
31619748-1	2020	Tenofovir disoproxyl fumarate (TDF) has been associated with renal tubular abnormalities, phosphaturia and proteinuria (retinol binding protein, RBP, loss): vitamin D (VD) and PTH affect these markers.	tfv	31-34	parathyroid hormone	Homo sapiens	176-179
31619748-5	2020	Abnormal uRBP/Cr was more frequent in TDF recipients: eGFR <90 mL/min and TDF were predictors in the whole cohort, whereas eGFR <90 mL/min, TDF concentrations and CYP24A1-3999TT in TDF-treated patients.	tfv	38-41	epidermal growth factor receptor	Homo sapiens	54-58
31619748-5	2020	Abnormal uRBP/Cr was more frequent in TDF recipients: eGFR <90 mL/min and TDF were predictors in the whole cohort, whereas eGFR <90 mL/min, TDF concentrations and CYP24A1-3999TT in TDF-treated patients.	tfv	38-41	epidermal growth factor receptor	Homo sapiens	126-130
31619748-5	2020	Abnormal uRBP/Cr was more frequent in TDF recipients: eGFR <90 mL/min and TDF were predictors in the whole cohort, whereas eGFR <90 mL/min, TDF concentrations and CYP24A1-3999TT in TDF-treated patients.	tfv	38-41	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	169-176
31619748-7	2020	PTH levels were border-line higher in TDF patients: non-European ancestry, females, TDF, VD levels < 30 ng/mL and SLC28A2-124CT/TT and ABCC2-24CC were predictors.	tfv	38-41	parathyroid hormone	Homo sapiens	0-3
31619748-7	2020	PTH levels were border-line higher in TDF patients: non-European ancestry, females, TDF, VD levels < 30 ng/mL and SLC28A2-124CT/TT and ABCC2-24CC were predictors.	tfv	38-41	solute carrier family 28 member 2	Homo sapiens	117-124
31619748-7	2020	PTH levels were border-line higher in TDF patients: non-European ancestry, females, TDF, VD levels < 30 ng/mL and SLC28A2-124CT/TT and ABCC2-24CC were predictors.	tfv	84-87	parathyroid hormone	Homo sapiens	0-3
32017579-10	2020	Accordingly, Multidrug Resistance associated Protein 2 (MRP2) in cervicovaginal tissue was upregulated by both tenofovir and darunavir.	tfv	111-120	ATP binding cassette subfamily C member 2	Homo sapiens	13-54
32017579-10	2020	Accordingly, Multidrug Resistance associated Protein 2 (MRP2) in cervicovaginal tissue was upregulated by both tenofovir and darunavir.	tfv	111-120	ATP binding cassette subfamily C member 2	Homo sapiens	56-60
32017579-13	2020	Modulation of drug transporter expression by tenofovir and darunavir points to the potential benefit of MRP2 inhibition to increase ARV drug penetration through the cervicovaginal epithelium.	tfv	45-54	ATP binding cassette subfamily C member 2	Homo sapiens	104-108
31749296-2	2020	TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by OAT1 and OAT3.	tfv	20-29	solute carrier family 22 member 8	Homo sapiens	116-120
31749296-2	2020	TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by OAT1 and OAT3.	tfv	31-34	solute carrier family 22 member 6	Homo sapiens	107-111
31749296-2	2020	TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by OAT1 and OAT3.	tfv	31-34	solute carrier family 22 member 8	Homo sapiens	116-120
31749296-3	2020	Using in vitro kinetic parameters for TFV and the OAT1 and OAT3 inhibitor probenecid, a bottom-up PBPK model was successfully developed for the first time that accurately describes the probenecid-TFV interaction.	tfv	196-199	solute carrier family 22 member 6	Homo sapiens	50-54
31749296-3	2020	Using in vitro kinetic parameters for TFV and the OAT1 and OAT3 inhibitor probenecid, a bottom-up PBPK model was successfully developed for the first time that accurately describes the probenecid-TFV interaction.	tfv	196-199	solute carrier family 22 member 8	Homo sapiens	59-63
31826005-1	2019	BACKGROUND: Because tenofovir alafenamide (TAF) leads to significantly lower plasma tenofovir concentrations than tenofovir disoproxil fumarate (TDF) and is a stronger substrate for P-glycoprotein (P-gp) than TDF, TAF could lead to decreased central nervous system (CNS) tenofovir exposure than TDF.	tfv	20-29	ATP binding cassette subfamily B member 1	Homo sapiens	182-196
31887187-9	2019	Among the co-infected, 47.6% were also positive for anti-HBc, of which 58% were on an ART containing tenofovir (TDF).	tfv	101-110	keratin 88, pseudogene	Homo sapiens	57-60