PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31814867-4	2019	Here, we first reported that polyphyllin VII (PP7) exhibited cytotoxic effect on glioma cells.	polyphyllin VII	29-44	protein phosphatase with EF-hand domain 1	Homo sapiens	46-49
33279335-0	2021	Polyphyllin VII induces fibroblasts apoptosis via the ERK/JNK pathway.	polyphyllin VII	0-15	mitogen-activated protein kinase 1	Homo sapiens	54-57
33279335-0	2021	Polyphyllin VII induces fibroblasts apoptosis via the ERK/JNK pathway.	polyphyllin VII	0-15	mitogen-activated protein kinase 8	Homo sapiens	58-61
33279335-5	2021	Polyphyllin VII (PP7) is an isoprene saponin isolated from Rhizoma paridis.	polyphyllin VII	0-15	protein phosphatase with EF-hand domain 1	Homo sapiens	17-20
33416159-0	2021	Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer.	polyphyllin VII	0-15	protein phosphatase 2 phosphatase activator	Homo sapiens	66-70
33416159-0	2021	Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer.	polyphyllin VII	0-15	AKT serine/threonine kinase 1	Homo sapiens	71-74
33416159-0	2021	Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer.	polyphyllin VII	0-15	dynamin 1 like	Homo sapiens	75-79
33416159-9	2021	In addition, polyphyllin VII enhanced the mitochondrial localization of DRP1 which is mediated by increased protein phosphatase 2A (PP2A) activity, and decreased AKT activity.	polyphyllin VII	13-28	dynamin 1 like	Homo sapiens	72-76
33416159-9	2021	In addition, polyphyllin VII enhanced the mitochondrial localization of DRP1 which is mediated by increased protein phosphatase 2A (PP2A) activity, and decreased AKT activity.	polyphyllin VII	13-28	protein phosphatase 2 phosphatase activator	Homo sapiens	116-130
33416159-9	2021	In addition, polyphyllin VII enhanced the mitochondrial localization of DRP1 which is mediated by increased protein phosphatase 2A (PP2A) activity, and decreased AKT activity.	polyphyllin VII	13-28	protein phosphatase 2 phosphatase activator	Homo sapiens	132-136
33416159-9	2021	In addition, polyphyllin VII enhanced the mitochondrial localization of DRP1 which is mediated by increased protein phosphatase 2A (PP2A) activity, and decreased AKT activity.	polyphyllin VII	13-28	AKT serine/threonine kinase 1	Homo sapiens	162-165
33416159-10	2021	A specific PP2A inhibitor, LB100, attenuated mitochondrial division and apoptosis in cells caused by polyphyllin VII, confirming the function of the PP2A/AKT pathway in polyphyllin VII treatment.	polyphyllin VII	101-116	protein phosphatase 2 phosphatase activator	Homo sapiens	11-15
33416159-10	2021	A specific PP2A inhibitor, LB100, attenuated mitochondrial division and apoptosis in cells caused by polyphyllin VII, confirming the function of the PP2A/AKT pathway in polyphyllin VII treatment.	polyphyllin VII	101-116	AKT serine/threonine kinase 1	Homo sapiens	154-157
33416159-10	2021	A specific PP2A inhibitor, LB100, attenuated mitochondrial division and apoptosis in cells caused by polyphyllin VII, confirming the function of the PP2A/AKT pathway in polyphyllin VII treatment.	polyphyllin VII	169-184	protein phosphatase 2 phosphatase activator	Homo sapiens	11-15
33416159-10	2021	A specific PP2A inhibitor, LB100, attenuated mitochondrial division and apoptosis in cells caused by polyphyllin VII, confirming the function of the PP2A/AKT pathway in polyphyllin VII treatment.	polyphyllin VII	169-184	protein phosphatase 2 phosphatase activator	Homo sapiens	149-153
33416159-10	2021	A specific PP2A inhibitor, LB100, attenuated mitochondrial division and apoptosis in cells caused by polyphyllin VII, confirming the function of the PP2A/AKT pathway in polyphyllin VII treatment.	polyphyllin VII	169-184	AKT serine/threonine kinase 1	Homo sapiens	154-157
32075617-0	2020	Polyphyllin VII attenuated RANKL-induced osteoclast differentiation via inhibiting of TRAF6/c-Src/PI3K pathway and ROS production.	polyphyllin VII	0-15	TNF superfamily member 11	Homo sapiens	27-32
32075617-0	2020	Polyphyllin VII attenuated RANKL-induced osteoclast differentiation via inhibiting of TRAF6/c-Src/PI3K pathway and ROS production.	polyphyllin VII	0-15	TNF receptor associated factor 6	Homo sapiens	86-91
32075617-0	2020	Polyphyllin VII attenuated RANKL-induced osteoclast differentiation via inhibiting of TRAF6/c-Src/PI3K pathway and ROS production.	polyphyllin VII	0-15	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	92-97
32075617-6	2020	RESULTS: RANKL + M-CSF significantly increased TRAP activity, number of osteoclasts, number and area of lacunae, intracellular content of ROS, protein levels of Nox1, TRAF6, c-Src and p-PI3K, as well as the content of activated GTP-Rac1, which were significantly blocked by polyphyllin VII in a concentration-dependent manner.	polyphyllin VII	274-289	TNF superfamily member 11	Homo sapiens	9-14
32075617-6	2020	RESULTS: RANKL + M-CSF significantly increased TRAP activity, number of osteoclasts, number and area of lacunae, intracellular content of ROS, protein levels of Nox1, TRAF6, c-Src and p-PI3K, as well as the content of activated GTP-Rac1, which were significantly blocked by polyphyllin VII in a concentration-dependent manner.	polyphyllin VII	274-289	colony stimulating factor 1	Homo sapiens	17-22
32075617-7	2020	CONCLUSION: These findings suggested that polyphyllin VII inhibited differentiation of BMMs into osteoclasts through suppressing ROS synthesis, which was modulated by TRAF6-cSrc-PI3k signal transduction pathway including GTP-Rac1 and Nox1.	polyphyllin VII	42-57	TNF receptor associated factor 6	Homo sapiens	167-172
32075617-7	2020	CONCLUSION: These findings suggested that polyphyllin VII inhibited differentiation of BMMs into osteoclasts through suppressing ROS synthesis, which was modulated by TRAF6-cSrc-PI3k signal transduction pathway including GTP-Rac1 and Nox1.	polyphyllin VII	42-57	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	173-177
32075617-7	2020	CONCLUSION: These findings suggested that polyphyllin VII inhibited differentiation of BMMs into osteoclasts through suppressing ROS synthesis, which was modulated by TRAF6-cSrc-PI3k signal transduction pathway including GTP-Rac1 and Nox1.	polyphyllin VII	42-57	Rac family small GTPase 1	Homo sapiens	225-229
32075617-7	2020	CONCLUSION: These findings suggested that polyphyllin VII inhibited differentiation of BMMs into osteoclasts through suppressing ROS synthesis, which was modulated by TRAF6-cSrc-PI3k signal transduction pathway including GTP-Rac1 and Nox1.	polyphyllin VII	42-57	NADPH oxidase 1	Homo sapiens	234-238
33416129-0	2021	Polyphyllin VII induces apoptosis and autophagy via mediating H2O2 levels and the JNK pathway in human osteosarcoma U2OS cells.	polyphyllin VII	0-15	mitogen-activated protein kinase 8	Homo sapiens	82-85
33416129-3	2021	The present study revealed that Polyphyllin VII promoted OS cell apoptosis and inhibited cell proliferation via upregulating the expression of LC3II, Atg5, Atg7 and the Atg12-Atg5 complex.	polyphyllin VII	32-47	autophagy related 5	Homo sapiens	150-154
33416129-3	2021	The present study revealed that Polyphyllin VII promoted OS cell apoptosis and inhibited cell proliferation via upregulating the expression of LC3II, Atg5, Atg7 and the Atg12-Atg5 complex.	polyphyllin VII	32-47	autophagy related 7	Homo sapiens	156-160
33416129-3	2021	The present study revealed that Polyphyllin VII promoted OS cell apoptosis and inhibited cell proliferation via upregulating the expression of LC3II, Atg5, Atg7 and the Atg12-Atg5 complex.	polyphyllin VII	32-47	autophagy related 12	Homo sapiens	169-174
33416129-3	2021	The present study revealed that Polyphyllin VII promoted OS cell apoptosis and inhibited cell proliferation via upregulating the expression of LC3II, Atg5, Atg7 and the Atg12-Atg5 complex.	polyphyllin VII	32-47	autophagy related 5	Homo sapiens	175-179
33416129-4	2021	By contrast, treatment of OS cells with Polyphyllin VII downregulated Atg12 and p62 expression.	polyphyllin VII	40-55	autophagy related 12	Homo sapiens	70-75
33416129-4	2021	By contrast, treatment of OS cells with Polyphyllin VII downregulated Atg12 and p62 expression.	polyphyllin VII	40-55	nucleoporin 62	Homo sapiens	80-83
33416129-9	2021	The western blot analysis results indicated that the c-Jun N-terminal kinase (JNK) signaling pathway was closely associated with Polyphyllin VII-induced apoptosis and autophagy.	polyphyllin VII	129-144	mitogen-activated protein kinase 8	Homo sapiens	53-76
33416129-9	2021	The western blot analysis results indicated that the c-Jun N-terminal kinase (JNK) signaling pathway was closely associated with Polyphyllin VII-induced apoptosis and autophagy.	polyphyllin VII	129-144	mitogen-activated protein kinase 8	Homo sapiens	78-81
26861252-0	2016	Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways.	polyphyllin VII	0-15	mitogen-activated protein kinase 1	Homo sapiens	100-104
30338602-0	2019	The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase-mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis.	polyphyllin VII	54-69	beclin 1	Homo sapiens	108-115
29352966-7	2018	The IC50 of Polyphyllin G ranged from 10 to 65 muM.	polyphyllin VII	12-25	latexin	Homo sapiens	47-50
29352966-8	2018	However the IC50 of Polyphyllin G was found to be comparatively high (120 muM) against the normal FR2 cancer cell line.	polyphyllin VII	20-33	latexin	Homo sapiens	74-77
29352966-11	2018	Our results indicated that Polyphyllin G induced cell arrest in oral cancer OECM-1 cells by inactivation of cdc25C-cdc22 via ATM-Chk 1/2 stimulation.	polyphyllin VII	27-40	checkpoint kinase 1	Homo sapiens	129-134
27823618-5	2016	RESULTS: The results revealed that polyphyllin G significantly inhibited cell proliferation in human oral cancer cells; it dose-dependently induced apoptosis in SAS and OECM-1 cells through caspase-3, -8, and -9 activation and poly (ADP-ribose) polymerase cleavage.	polyphyllin VII	35-48	caspase 3	Homo sapiens	190-211
27823618-7	2016	The expression of both LC3-II and beclin-1 was markedly increased, suggesting the induction of autophagy in polyphyllin G-treated oral cells.	polyphyllin VII	108-121	beclin 1	Homo sapiens	34-42
27823618-8	2016	To further clarify whether polyphyllin G-induced apoptosis and autophagy depended on Akt/extracellular signal-regulated kinases (ERK)/c-Jun N-terminal kinases (JNK)/p38 mitogen-activated protein kinases (MAPK) signaling pathways, the cells were cotreated with inhibitors.	polyphyllin VII	27-40	mitogen-activated protein kinase 1	Homo sapiens	85-127
27823618-8	2016	To further clarify whether polyphyllin G-induced apoptosis and autophagy depended on Akt/extracellular signal-regulated kinases (ERK)/c-Jun N-terminal kinases (JNK)/p38 mitogen-activated protein kinases (MAPK) signaling pathways, the cells were cotreated with inhibitors.	polyphyllin VII	27-40	mitogen-activated protein kinase 1	Homo sapiens	129-132
27602962-6	2016	To further clarify whether Polyphyllin G-induced apoptosis and autophagy depended on AKT/ERK/JNK/p38 MAPK signaling pathways, cells were combined treated with AKT inhibitor (LY294002), ERK1/2 inhibitor (U0126), p38 MAPK inhibitor (SB203580), or JNK inhibitor (SP600125).	polyphyllin VII	27-40	mitogen-activated protein kinase 8	Homo sapiens	245-248
27602962-7	2016	These results demonstrated that Polyphyllin G induced apoptosis in NPC cells through activation of ERK, while AKT, p38 MAPK and JNK were responsible for Polyphyllin G-induced autophagy.	polyphyllin VII	32-45	mitogen-activated protein kinase 1	Homo sapiens	99-102
27602962-7	2016	These results demonstrated that Polyphyllin G induced apoptosis in NPC cells through activation of ERK, while AKT, p38 MAPK and JNK were responsible for Polyphyllin G-induced autophagy.	polyphyllin VII	153-166	AKT serine/threonine kinase 1	Homo sapiens	110-113
27602962-7	2016	These results demonstrated that Polyphyllin G induced apoptosis in NPC cells through activation of ERK, while AKT, p38 MAPK and JNK were responsible for Polyphyllin G-induced autophagy.	polyphyllin VII	153-166	mitogen-activated protein kinase 1	Homo sapiens	115-118
27602962-7	2016	These results demonstrated that Polyphyllin G induced apoptosis in NPC cells through activation of ERK, while AKT, p38 MAPK and JNK were responsible for Polyphyllin G-induced autophagy.	polyphyllin VII	153-166	mitogen-activated protein kinase 3	Homo sapiens	119-123
27602962-7	2016	These results demonstrated that Polyphyllin G induced apoptosis in NPC cells through activation of ERK, while AKT, p38 MAPK and JNK were responsible for Polyphyllin G-induced autophagy.	polyphyllin VII	153-166	mitogen-activated protein kinase 8	Homo sapiens	128-131
29352966-0	2018	Polyphyllin G exhibits antimicrobial activity and exerts anticancer effects on human oral cancer OECM-1 cells by triggering G2/M cell cycle arrest by inactivating cdc25C-cdc2.	polyphyllin VII	0-13	cell division cycle 25C	Homo sapiens	163-174
28757172-0	2017	Polyphyllin VII increases sensitivity to gefitinib by modulating the elevation of P21 in acquired gefitinib resistant non-small cell lung cancer.	polyphyllin VII	0-15	H3 histone pseudogene 16	Homo sapiens	82-85
28757172-4	2017	The sensitizing effect and underlying mechanism of Polyphyllin VII against acquired EGFR-TKI resistant NSCLC are still unexplored.	polyphyllin VII	51-66	epidermal growth factor receptor	Homo sapiens	84-88
28757172-5	2017	In the present study, we aim to examined the sensitizing effect of Polyphyllin VII to gefitinib by modulating P21 signaling pathway in gefitinib acquired resistant NSCLC in vitro and in vivo.	polyphyllin VII	67-82	H3 histone pseudogene 16	Homo sapiens	110-113
28757172-8	2017	Polyphyllin VII enhanced the anti-proliferative effects of gefitinib and gefitinib-induced G1 phase arrest by modulation of P21 signaling pathway in acquired gefitinib resistant cells in vitro and in vivo.	polyphyllin VII	0-15	H3 histone pseudogene 16	Homo sapiens	124-127
28757172-9	2017	Polyphyllin VII elevated sensitization of gefitinib acquired resistant NSCLC cells to gefitinib through G1 phase arrest and modulation of P21 signaling pathway.	polyphyllin VII	0-15	H3 histone pseudogene 16	Homo sapiens	138-141
27823618-8	2016	To further clarify whether polyphyllin G-induced apoptosis and autophagy depended on Akt/extracellular signal-regulated kinases (ERK)/c-Jun N-terminal kinases (JNK)/p38 mitogen-activated protein kinases (MAPK) signaling pathways, the cells were cotreated with inhibitors.	polyphyllin VII	27-40	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-139
27823618-8	2016	To further clarify whether polyphyllin G-induced apoptosis and autophagy depended on Akt/extracellular signal-regulated kinases (ERK)/c-Jun N-terminal kinases (JNK)/p38 mitogen-activated protein kinases (MAPK) signaling pathways, the cells were cotreated with inhibitors.	polyphyllin VII	27-40	mitogen-activated protein kinase 8	Homo sapiens	160-163
27823618-8	2016	To further clarify whether polyphyllin G-induced apoptosis and autophagy depended on Akt/extracellular signal-regulated kinases (ERK)/c-Jun N-terminal kinases (JNK)/p38 mitogen-activated protein kinases (MAPK) signaling pathways, the cells were cotreated with inhibitors.	polyphyllin VII	27-40	mitogen-activated protein kinase 1	Homo sapiens	165-168
27823618-8	2016	To further clarify whether polyphyllin G-induced apoptosis and autophagy depended on Akt/extracellular signal-regulated kinases (ERK)/c-Jun N-terminal kinases (JNK)/p38 mitogen-activated protein kinases (MAPK) signaling pathways, the cells were cotreated with inhibitors.	polyphyllin VII	27-40	mitogen-activated protein kinase 1	Homo sapiens	204-208
27823618-9	2016	The results demonstrated polyphyllin G-induced apoptosis in oral cells through the activation of ERK, Akt, p38 MAPK, and JNK, whereas ERK and JNK accounted for polyphyllin G-induced autophagy.	polyphyllin VII	25-38	mitogen-activated protein kinase 1	Homo sapiens	97-100
27823618-9	2016	The results demonstrated polyphyllin G-induced apoptosis in oral cells through the activation of ERK, Akt, p38 MAPK, and JNK, whereas ERK and JNK accounted for polyphyllin G-induced autophagy.	polyphyllin VII	25-38	AKT serine/threonine kinase 1	Homo sapiens	102-105
27823618-9	2016	The results demonstrated polyphyllin G-induced apoptosis in oral cells through the activation of ERK, Akt, p38 MAPK, and JNK, whereas ERK and JNK accounted for polyphyllin G-induced autophagy.	polyphyllin VII	25-38	mitogen-activated protein kinase 1	Homo sapiens	107-110
27823618-9	2016	The results demonstrated polyphyllin G-induced apoptosis in oral cells through the activation of ERK, Akt, p38 MAPK, and JNK, whereas ERK and JNK accounted for polyphyllin G-induced autophagy.	polyphyllin VII	25-38	mitogen-activated protein kinase 8	Homo sapiens	121-124
27823618-9	2016	The results demonstrated polyphyllin G-induced apoptosis in oral cells through the activation of ERK, Akt, p38 MAPK, and JNK, whereas ERK and JNK accounted for polyphyllin G-induced autophagy.	polyphyllin VII	160-173	mitogen-activated protein kinase 1	Homo sapiens	134-137
27823618-9	2016	The results demonstrated polyphyllin G-induced apoptosis in oral cells through the activation of ERK, Akt, p38 MAPK, and JNK, whereas ERK and JNK accounted for polyphyllin G-induced autophagy.	polyphyllin VII	160-173	mitogen-activated protein kinase 8	Homo sapiens	142-145
27602962-0	2016	Polyphyllin G induce apoptosis and autophagy in human nasopharyngeal cancer cells by modulation of AKT and mitogen-activated protein kinase pathways in vitro and in vivo.	polyphyllin VII	0-13	AKT serine/threonine kinase 1	Homo sapiens	99-102
27602962-4	2016	In this study, Polyphyllin G can potently induced apoptosis dependent on the activations of caspase-8, -3, and -9 and the changes of Bcl-2, Bcl-xL and Bax protein expression in different human NPC cell lines (HONE-1 and NPC-039).	polyphyllin VII	15-28	caspase 8	Homo sapiens	92-113
27602962-4	2016	In this study, Polyphyllin G can potently induced apoptosis dependent on the activations of caspase-8, -3, and -9 and the changes of Bcl-2, Bcl-xL and Bax protein expression in different human NPC cell lines (HONE-1 and NPC-039).	polyphyllin VII	15-28	BCL2 apoptosis regulator	Homo sapiens	133-138
27602962-4	2016	In this study, Polyphyllin G can potently induced apoptosis dependent on the activations of caspase-8, -3, and -9 and the changes of Bcl-2, Bcl-xL and Bax protein expression in different human NPC cell lines (HONE-1 and NPC-039).	polyphyllin VII	15-28	BCL2 like 1	Homo sapiens	140-146
27602962-4	2016	In this study, Polyphyllin G can potently induced apoptosis dependent on the activations of caspase-8, -3, and -9 and the changes of Bcl-2, Bcl-xL and Bax protein expression in different human NPC cell lines (HONE-1 and NPC-039).	polyphyllin VII	15-28	BCL2 associated X, apoptosis regulator	Homo sapiens	151-154
27602962-5	2016	The amount of both LC3-II and Beclin-1 was intriguingly increased suggest that autophagy was induced in Polyphyllin G-treated NPC cells.	polyphyllin VII	104-117	beclin 1	Homo sapiens	30-38
27602962-6	2016	To further clarify whether Polyphyllin G-induced apoptosis and autophagy depended on AKT/ERK/JNK/p38 MAPK signaling pathways, cells were combined treated with AKT inhibitor (LY294002), ERK1/2 inhibitor (U0126), p38 MAPK inhibitor (SB203580), or JNK inhibitor (SP600125).	polyphyllin VII	27-40	AKT serine/threonine kinase 1	Homo sapiens	85-88
27602962-6	2016	To further clarify whether Polyphyllin G-induced apoptosis and autophagy depended on AKT/ERK/JNK/p38 MAPK signaling pathways, cells were combined treated with AKT inhibitor (LY294002), ERK1/2 inhibitor (U0126), p38 MAPK inhibitor (SB203580), or JNK inhibitor (SP600125).	polyphyllin VII	27-40	mitogen-activated protein kinase 1	Homo sapiens	89-92
27602962-6	2016	To further clarify whether Polyphyllin G-induced apoptosis and autophagy depended on AKT/ERK/JNK/p38 MAPK signaling pathways, cells were combined treated with AKT inhibitor (LY294002), ERK1/2 inhibitor (U0126), p38 MAPK inhibitor (SB203580), or JNK inhibitor (SP600125).	polyphyllin VII	27-40	mitogen-activated protein kinase 8	Homo sapiens	93-96
27602962-6	2016	To further clarify whether Polyphyllin G-induced apoptosis and autophagy depended on AKT/ERK/JNK/p38 MAPK signaling pathways, cells were combined treated with AKT inhibitor (LY294002), ERK1/2 inhibitor (U0126), p38 MAPK inhibitor (SB203580), or JNK inhibitor (SP600125).	polyphyllin VII	27-40	mitogen-activated protein kinase 1	Homo sapiens	97-100
27602962-6	2016	To further clarify whether Polyphyllin G-induced apoptosis and autophagy depended on AKT/ERK/JNK/p38 MAPK signaling pathways, cells were combined treated with AKT inhibitor (LY294002), ERK1/2 inhibitor (U0126), p38 MAPK inhibitor (SB203580), or JNK inhibitor (SP600125).	polyphyllin VII	27-40	mitogen-activated protein kinase 3	Homo sapiens	101-105
27602962-6	2016	To further clarify whether Polyphyllin G-induced apoptosis and autophagy depended on AKT/ERK/JNK/p38 MAPK signaling pathways, cells were combined treated with AKT inhibitor (LY294002), ERK1/2 inhibitor (U0126), p38 MAPK inhibitor (SB203580), or JNK inhibitor (SP600125).	polyphyllin VII	27-40	AKT serine/threonine kinase 1	Homo sapiens	159-162
27602962-6	2016	To further clarify whether Polyphyllin G-induced apoptosis and autophagy depended on AKT/ERK/JNK/p38 MAPK signaling pathways, cells were combined treated with AKT inhibitor (LY294002), ERK1/2 inhibitor (U0126), p38 MAPK inhibitor (SB203580), or JNK inhibitor (SP600125).	polyphyllin VII	27-40	mitogen-activated protein kinase 3	Homo sapiens	185-191
27602962-6	2016	To further clarify whether Polyphyllin G-induced apoptosis and autophagy depended on AKT/ERK/JNK/p38 MAPK signaling pathways, cells were combined treated with AKT inhibitor (LY294002), ERK1/2 inhibitor (U0126), p38 MAPK inhibitor (SB203580), or JNK inhibitor (SP600125).	polyphyllin VII	27-40	mitogen-activated protein kinase 1	Homo sapiens	211-214
26861252-2	2016	Polyphyllin VII (PP7), a pennogenyl saponin from P. polyphylla has been found to exert strong anticancer activity.	polyphyllin VII	0-15	protein phosphatase with EF-hand domain 1	Homo sapiens	17-20
26808193-0	2016	Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells.	polyphyllin VII	0-15	mitogen-activated protein kinase 8	Homo sapiens	70-73
26808193-0	2016	Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells.	polyphyllin VII	0-15	AKT serine/threonine kinase 1	Homo sapiens	105-108
26808193-0	2016	Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells.	polyphyllin VII	0-15	mechanistic target of rapamycin kinase	Homo sapiens	109-113
26808193-1	2016	Polyphyllin VII (PP7), a pennogenyl saponin isolated from Rhizoma Paridis, exhibited strong anticancer activities in various cancer types.	polyphyllin VII	0-15	protein phosphatase with EF-hand domain 1	Homo sapiens	17-20