PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29636694-0	2018	Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin.	bixin	8-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	22-26
30120979-0	2018	Therapeutic potential of bixin in PM2.5 particles-induced lung injury in an Nrf2-dependent manner.	bixin	25-30	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
30064749-3	2018	Lipase-catalyzed reactions of bixin with sorbitol were studied to synthesize a new derivative of bixin with potential hydrophilic properties.	bixin	30-35	PAN0_003d1715	Moesziomyces antarcticus	0-6
30064749-3	2018	Lipase-catalyzed reactions of bixin with sorbitol were studied to synthesize a new derivative of bixin with potential hydrophilic properties.	bixin	97-102	PAN0_003d1715	Moesziomyces antarcticus	0-6
30204479-5	2018	Treatment of bixin significantly decreased the number of Hep3B cells and morphological study revealed the change in cellular and nuclear morphology that trigger the events of apoptosis confirmed by annexin V/PI staining.	bixin	13-18	annexin A5	Homo sapiens	198-207
29636694-4	2018	Here, we tested the feasibility of topical use of bixin for NRF2-dependent skin photoprotection in two genetically modified mouse models [SKH1 and C57BL/6J (Nrf2+/+ versus Nrf2-/- )].	bixin	50-55	nuclear factor, erythroid derived 2, like 2	Mus musculus	60-64
29636694-5	2018	First, we observed that a bixin formulation optimized for topical NRF2 activation suppresses acute UV-induced photodamage in Nrf2+/+ but not Nrf2-/- SKH1 mice, a photoprotective effect indicated by reduced epidermal hyperproliferation and oxidative DNA damage.	bixin	26-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
29636694-5	2018	First, we observed that a bixin formulation optimized for topical NRF2 activation suppresses acute UV-induced photodamage in Nrf2+/+ but not Nrf2-/- SKH1 mice, a photoprotective effect indicated by reduced epidermal hyperproliferation and oxidative DNA damage.	bixin	26-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	125-129
29636694-6	2018	Secondly, it was demonstrated that topical bixin suppresses PUVA (psoralen + UVA)-induced hair graying in Nrf2+/+ but not Nrf2-/- C57BL/6J mice.	bixin	43-48	nuclear factor, erythroid derived 2, like 2	Mus musculus	106-110
29636694-7	2018	Collectively, this research provides the first in vivo evidence that topical application of bixin can protect against UV-induced photodamage and PUVA-induced loss of hair pigmentation through NRF2 activation.	bixin	92-97	nuclear factor, erythroid derived 2, like 2	Mus musculus	192-196
27292445-6	2017	The initial Bixin release domain showed a burst release over the first 10 hours where approximately 30% and 40% of Bixin was released from Bix-PCL1 and Bix-PCL2 nanofibers, respectively.	bixin	12-17	PHD finger protein 1	Mus musculus	143-147
30090580-0	2018	Bixin protects against particle-induced long-term lung injury in an NRF2-dependent manner.	bixin	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	68-72
30090580-9	2018	injection of bixin in mice led to the upregulation of the NRF2 response in the lungs.	bixin	13-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	58-62
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	35-40	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	35-40	NFE2 like bZIP transcription factor 2	Homo sapiens	201-205
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	35-40	NFE2 like bZIP transcription factor 2	Homo sapiens	341-345
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	35-40	NFE2 like bZIP transcription factor 2	Homo sapiens	360-364
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	35-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	201-205
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	185-190	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	185-190	NFE2 like bZIP transcription factor 2	Homo sapiens	201-205
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	185-190	NFE2 like bZIP transcription factor 2	Homo sapiens	341-345
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	185-190	NFE2 like bZIP transcription factor 2	Homo sapiens	360-364
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	185-190	nuclear factor, erythroid derived 2, like 2	Mus musculus	201-205
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	185-190	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	185-190	NFE2 like bZIP transcription factor 2	Homo sapiens	201-205
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	185-190	NFE2 like bZIP transcription factor 2	Homo sapiens	341-345
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	185-190	NFE2 like bZIP transcription factor 2	Homo sapiens	360-364
29258247-5	2017	We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2-/- SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects.	bixin	185-190	nuclear factor, erythroid derived 2, like 2	Mus musculus	201-205
27292445-6	2017	The initial Bixin release domain showed a burst release over the first 10 hours where approximately 30% and 40% of Bixin was released from Bix-PCL1 and Bix-PCL2 nanofibers, respectively.	bixin	12-17	metal response element binding transcription factor 2	Mus musculus	156-160
27292445-6	2017	The initial Bixin release domain showed a burst release over the first 10 hours where approximately 30% and 40% of Bixin was released from Bix-PCL1 and Bix-PCL2 nanofibers, respectively.	bixin	115-120	PHD finger protein 1	Mus musculus	143-147
26187443-6	2016	The results of the in vitro studies suggested that higher concentrations of bixin and norbixin inhibited tyrosinase activity in B16F0 melanoma cells.	bixin	76-81	tyrosinase	Mus musculus	105-115
26729554-0	2016	Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner.	bixin	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
26729554-3	2016	This study explored the feasibility of using bixin, a canonical NRF2 inducer identified during the current study, to ameliorate lung damage in a murine VILI model.	bixin	45-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	64-68
26729554-4	2016	In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal (IP) injection of bixin led to pulmonary upregulation of the NRF2 response in vivo.	bixin	10-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	42-46
26729554-4	2016	In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal (IP) injection of bixin led to pulmonary upregulation of the NRF2 response in vivo.	bixin	10-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
26729554-4	2016	In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal (IP) injection of bixin led to pulmonary upregulation of the NRF2 response in vivo.	bixin	10-15	kelch-like ECH-associated protein 1	Mus musculus	129-134
26729554-4	2016	In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal (IP) injection of bixin led to pulmonary upregulation of the NRF2 response in vivo.	bixin	10-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
26729554-4	2016	In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal (IP) injection of bixin led to pulmonary upregulation of the NRF2 response in vivo.	bixin	192-197	nuclear factor, erythroid derived 2, like 2	Mus musculus	42-46
26729554-4	2016	In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal (IP) injection of bixin led to pulmonary upregulation of the NRF2 response in vivo.	bixin	192-197	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
26729554-4	2016	In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal (IP) injection of bixin led to pulmonary upregulation of the NRF2 response in vivo.	bixin	192-197	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
26729554-6	2016	This observed beneficial effect of bixin derived from induction of the NRF2 cytoprotective response since it was only observed in Nrf2(+/+) but not in Nrf2(-/-) mice.	bixin	35-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	71-75
26729554-6	2016	This observed beneficial effect of bixin derived from induction of the NRF2 cytoprotective response since it was only observed in Nrf2(+/+) but not in Nrf2(-/-) mice.	bixin	35-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	130-134
26812320-13	2016	Bixin also appeared to stimulate immune response, as seen with cell-mediated responses, and exerted anti-inflammatory (reduced CRP) as well as antioxidative (reduced 8-OHdG) effects in dogs.	bixin	0-5	C-reactive protein	Canis lupus familiaris	127-130
26187443-1	2016	In this present study, the inhibitory mechanism of three selected apocarotenoids (bixin, norbixin and crocin) on the diphenolase activity of tyrosinase has been investigated.	bixin	82-87	tyrosinase	Mus musculus	141-151
26456052-4	2015	Bixin activates NRF2 through the critical Cys-151 sensor residue in KEAP1, orchestrating a broad cytoprotective response in cultured human keratinocytes as revealed by antioxidant gene expression array analysis.	bixin	0-5	NFE2 like bZIP transcription factor 2	Homo sapiens	16-20
26456052-4	2015	Bixin activates NRF2 through the critical Cys-151 sensor residue in KEAP1, orchestrating a broad cytoprotective response in cultured human keratinocytes as revealed by antioxidant gene expression array analysis.	bixin	0-5	kelch like ECH associated protein 1	Homo sapiens	68-73
26456052-5	2015	Following dose optimization studies for cutaneous NRF2 activation by systemic administration of bixin, feasibility of bixin-based suppression of acute cutaneous photodamage from solar UV exposure was investigated in Nrf2(+/+) versus Nrf2(-/-) SKH-1 mice.	bixin	118-123	nuclear factor, erythroid derived 2, like 2	Mus musculus	216-220
26456052-6	2015	Systemic administration of bixin suppressed skin photodamage, attenuating epidermal oxidative DNA damage and inflammatory responses in Nrf2(+/+) but not in Nrf2(-/-) mice, confirming the NRF2-dependence of bixin-based cytoprotection.	bixin	27-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	135-139
21777644-6	2011	These findings suggested that perhaps bixin was responsible for the positive responses in both the LLNA and MEST following exposure to ANT.	bixin	38-43	mesoderm specific transcript	Mus musculus	108-112
25702177-7	2015	This protective effect of BIX was accompanied by decrease in the levels of tumor necrosis factor alpha by 15%, interleukin 6 by 19%, lipid peroxidation by 60%, non-high-density lipoprotein cholesterol (non-HDL-C) by 37%, and triglycerides by 41%.	bixin	26-29	tumor necrosis factor	Oryctolagus cuniculus	75-102
25702177-7	2015	This protective effect of BIX was accompanied by decrease in the levels of tumor necrosis factor alpha by 15%, interleukin 6 by 19%, lipid peroxidation by 60%, non-high-density lipoprotein cholesterol (non-HDL-C) by 37%, and triglycerides by 41%.	bixin	26-29	interleukin-6	Oryctolagus cuniculus	111-124
25299839-3	2014	In this study, we evaluated the protective effect of bixin on liver damage induced by carbon tetrachloride (CCl4) in rats.	bixin	53-58	C-C motif chemokine ligand 4	Rattus norvegicus	108-112
25299839-8	2014	Bixin prevented the liver damage caused by CCl4, as noted by the significant decrease in serum aminotransferases release.	bixin	0-5	C-C motif chemokine ligand 4	Rattus norvegicus	43-47
25299839-9	2014	Bixin protected the liver against the oxidizing effects of CCl4 by preventing a decrease in glutathione reductase activity and the levels of reduced glutathione and NADPH.	bixin	0-5	C-C motif chemokine ligand 4	Rattus norvegicus	59-63
25299839-9	2014	Bixin protected the liver against the oxidizing effects of CCl4 by preventing a decrease in glutathione reductase activity and the levels of reduced glutathione and NADPH.	bixin	0-5	glutathione-disulfide reductase	Rattus norvegicus	92-113
25299839-11	2014	CONCLUSION: Therefore, we can conclude that the protective effect of bixin against hepatotoxicity induced by CCl4 is related to the antioxidant activity of the compound.	bixin	69-74	C-C motif chemokine ligand 4	Rattus norvegicus	109-113
26456052-6	2015	Systemic administration of bixin suppressed skin photodamage, attenuating epidermal oxidative DNA damage and inflammatory responses in Nrf2(+/+) but not in Nrf2(-/-) mice, confirming the NRF2-dependence of bixin-based cytoprotection.	bixin	27-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	187-191
23554079-0	2013	Effect of bixin and norbixin on the expression of cytochrome P450 in HepG2 cell line.	bixin	10-15	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	50-65
23554079-3	2013	In this study, the ability of bixin and norbixin to induce the cytochrome P450 (CYP) enzymes was assessed in HepG2 human hepatoma cell line.	bixin	30-35	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-78
23554079-3	2013	In this study, the ability of bixin and norbixin to induce the cytochrome P450 (CYP) enzymes was assessed in HepG2 human hepatoma cell line.	bixin	30-35	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	80-83
21777644-8	2011	Positive responses in both the LLNA and MEST were observed in mice treated with cis-bixin at the concentrations as low as 0.1-0.5%.	bixin	80-89	mesoderm specific transcript	Mus musculus	40-44
34678694-0	2021	Bixin protects mice against bronchial asthma though modulating PI3K/Akt pathway.	bixin	0-5	thymoma viral proto-oncogene 1	Mus musculus	68-71
21307572-6	2011	Farnesol (2.89 microM) and bixin (21.1 microM), which we have reported to be PPARgamma ligands, increased the fluorescent polarization.	bixin	27-32	peroxisome proliferator activated receptor gamma	Homo sapiens	77-86
15769172-2	2005	The curves for the decay of bixin and formation of products (e.g., di-cis and all-trans isomers and a C17 degradation compound) did not adjust well to a first-order rate law, but very good fits were obtained using a biexponential model.	bixin	28-33	cytokine like 1	Homo sapiens	102-105
15769172-5	2005	In fact, the di-cis isomers could easily revert to bixin (Ea approximately 3 kcal/mol) or yield the primary C17 degradation product, with an energy barrier of 6.5 kcal/mol.	bixin	51-56	cytokine like 1	Homo sapiens	108-111
21620794-8	2011	In addition, beta-carotene, astaxanthin, capsanthin and bixin also up-regulated the expression of Nrf2, an important transcription factor in Keap1-Nrf2/EpRE/ARE signaling pathway.	bixin	56-61	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
21620794-8	2011	In addition, beta-carotene, astaxanthin, capsanthin and bixin also up-regulated the expression of Nrf2, an important transcription factor in Keap1-Nrf2/EpRE/ARE signaling pathway.	bixin	56-61	kelch like ECH associated protein 1	Homo sapiens	141-146
21620794-8	2011	In addition, beta-carotene, astaxanthin, capsanthin and bixin also up-regulated the expression of Nrf2, an important transcription factor in Keap1-Nrf2/EpRE/ARE signaling pathway.	bixin	56-61	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
34678694-5	2021	In vitro studies showed that Bixin treatment could inhibit the development of epithelial-mesenchymal transition (EMT) mediated by transforming growth factor beta (TGF-beta) signaling.	bixin	29-34	transforming growth factor alpha	Mus musculus	163-171
34678694-6	2021	Importantly, Bixin antagonized activation of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway both in vitro and in vivo.	bixin	13-18	thymoma viral proto-oncogene 1	Mus musculus	98-101
34678694-7	2021	Above all, our findings reveal that Bixin functions as a potent antagonist of PI3K/Akt signaling to protect against allergic asthma, highlighting a novel strategy for asthma treatment based on natural products.	bixin	36-41	thymoma viral proto-oncogene 1	Mus musculus	83-86
34107278-11	2021	Thereby, bixin may represent an alternative for the treatment of comorbidities associated with diabetes, counteracting oxidative stress and plasma HbA1.	bixin	9-14	hemoglobin alpha, adult chain 1	Rattus norvegicus	147-151
34107278-10	2021	BIX (at all tested doses) restored the oxidative parameters in tissues analyzed and reduced the plasma HbA1.	bixin	0-3	hemoglobin alpha, adult chain 1	Rattus norvegicus	103-107
33362775-8	2020	Furthermore, bixin inhibited inflammation and oxidative stress via activating nuclear factor erythroid 2-related factor 2 (NRF2), and its downstream genes in EAE mice, meanwhile, these effects were suppressed upon treatment with an NRF2 inhibitor, ML385.	bixin	13-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	232-236
33603948-0	2021	Bixin Attenuates High-Fat Diet-Caused Liver Steatosis and Inflammatory Injury through Nrf2/PPARalpha Signals.	bixin	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	86-90
33603948-0	2021	Bixin Attenuates High-Fat Diet-Caused Liver Steatosis and Inflammatory Injury through Nrf2/PPARalpha Signals.	bixin	0-5	peroxisome proliferator activated receptor alpha	Mus musculus	91-100
33603948-3	2021	Bixin acts as novel Nrf2 (NF-E2 p45-related factor 2) activator with the cytoprotection against oxidative stress and inflammation; this study mainly focused on the mechanism of Nrf2 activation by bixin and explored its potential feasibilities in long-term high-fat diet- (HFD-) caused hepatic steatosis and inflammatory response in vitro and in vivo.	bixin	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	20-24
33603948-3	2021	Bixin acts as novel Nrf2 (NF-E2 p45-related factor 2) activator with the cytoprotection against oxidative stress and inflammation; this study mainly focused on the mechanism of Nrf2 activation by bixin and explored its potential feasibilities in long-term high-fat diet- (HFD-) caused hepatic steatosis and inflammatory response in vitro and in vivo.	bixin	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	26-52
33603948-3	2021	Bixin acts as novel Nrf2 (NF-E2 p45-related factor 2) activator with the cytoprotection against oxidative stress and inflammation; this study mainly focused on the mechanism of Nrf2 activation by bixin and explored its potential feasibilities in long-term high-fat diet- (HFD-) caused hepatic steatosis and inflammatory response in vitro and in vivo.	bixin	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	177-181
33603948-3	2021	Bixin acts as novel Nrf2 (NF-E2 p45-related factor 2) activator with the cytoprotection against oxidative stress and inflammation; this study mainly focused on the mechanism of Nrf2 activation by bixin and explored its potential feasibilities in long-term high-fat diet- (HFD-) caused hepatic steatosis and inflammatory response in vitro and in vivo.	bixin	196-201	nuclear factor, erythroid derived 2, like 2	Mus musculus	177-181
33603948-4	2021	Bixin was found to activate Nrf2 signals by the modification of critical Keap1 (Kelch-like ECH-associated protein 1) cystine and competitive interaction with Keap1 with upregulating P62 mRNA and protein expression.	bixin	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	28-32
33603948-4	2021	Bixin was found to activate Nrf2 signals by the modification of critical Keap1 (Kelch-like ECH-associated protein 1) cystine and competitive interaction with Keap1 with upregulating P62 mRNA and protein expression.	bixin	0-5	kelch-like ECH-associated protein 1	Mus musculus	73-78
33603948-4	2021	Bixin was found to activate Nrf2 signals by the modification of critical Keap1 (Kelch-like ECH-associated protein 1) cystine and competitive interaction with Keap1 with upregulating P62 mRNA and protein expression.	bixin	0-5	kelch-like ECH-associated protein 1	Mus musculus	80-115
33603948-4	2021	Bixin was found to activate Nrf2 signals by the modification of critical Keap1 (Kelch-like ECH-associated protein 1) cystine and competitive interaction with Keap1 with upregulating P62 mRNA and protein expression.	bixin	0-5	kelch-like ECH-associated protein 1	Mus musculus	158-163
33603948-4	2021	Bixin was found to activate Nrf2 signals by the modification of critical Keap1 (Kelch-like ECH-associated protein 1) cystine and competitive interaction with Keap1 with upregulating P62 mRNA and protein expression.	bixin	0-5	nucleoporin 62	Mus musculus	182-185
33603948-5	2021	In human liver cells exposed to FFA (free fatty acid), bixin displayed a pronounced cytoprotective activity with upregulation of Nrf2-mediated gene expression, such as PPARalpha and its targets related with fatty acid oxidation.	bixin	55-60	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
33603948-5	2021	In human liver cells exposed to FFA (free fatty acid), bixin displayed a pronounced cytoprotective activity with upregulation of Nrf2-mediated gene expression, such as PPARalpha and its targets related with fatty acid oxidation.	bixin	55-60	peroxisome proliferator activated receptor alpha	Homo sapiens	168-177
33603948-6	2021	In HFD-fed mice, systemic administration of bixin attenuated lipid accumulation, decreased oxidant inflammatory damage in the liver, and reduced circulating lipid levels through Nrf2.	bixin	44-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	178-182
33603948-7	2021	Different from most of other established inducers, bixin activated Nrf2 signals through two different mechanisms with safe administration for protection of oxidant inflammatory damage and attenuation of lipid accumulation in the in vivo long-term HFD-fed mice.	bixin	51-56	nuclear factor, erythroid derived 2, like 2	Mus musculus	67-71
33603948-8	2021	Bixin represents a prototype Nrf2 activator that displays cytoprotective activity upon system administration targeting hepatic steatosis and oxidant inflammation originating from long-term HFD-fed mice.	bixin	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	29-33
33603948-9	2021	And bixin-based Nrf2-directed systemic intervention may also provide therapeutic benefit in protecting other organs in the process of metabolic syndrome.	bixin	4-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	16-20
33162346-0	2021	Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathway.	bixin	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	118-122
33162346-0	2021	Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathway.	bixin	0-5	toll-like receptor 4	Mus musculus	123-127
33162346-0	2021	Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathway.	bixin	0-5	myeloid differentiation primary response gene 88	Mus musculus	128-133
33162346-0	2021	Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathway.	bixin	0-5	peroxisome proliferator activated receptor gamma	Mus musculus	138-148
33162346-0	2021	Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathway.	bixin	0-5	transforming growth factor, beta 1	Mus musculus	149-158
33162346-0	2021	Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathway.	bixin	0-5	SMAD family member 3	Mus musculus	159-164
33162346-4	2021	Bixin ameliorated CCl4-induced inflammation in kidneys by reducing the levels of TNF-alpha and IL-1beta.	bixin	0-5	tumor necrosis factor	Mus musculus	81-90
33162346-4	2021	Bixin ameliorated CCl4-induced inflammation in kidneys by reducing the levels of TNF-alpha and IL-1beta.	bixin	0-5	interleukin 1 alpha	Mus musculus	95-103
33162346-5	2021	Bixin suppressed oxidative stress by decreasing the MDA level and increasing the activation of SOD, CAT and GPx.	bixin	0-5	catalase	Mus musculus	100-103
33162346-5	2021	Bixin suppressed oxidative stress by decreasing the MDA level and increasing the activation of SOD, CAT and GPx.	bixin	0-5	peroxiredoxin 6 pseudogene 2	Mus musculus	108-111
33162346-6	2021	Furthermore, Bixin increased the levels of PPAR-gamma, NQO1, HO-1 and the nuclear translocation of Nrf2 in the kidneys of mice.	bixin	13-18	peroxisome proliferator activated receptor gamma	Mus musculus	43-53
33162346-6	2021	Furthermore, Bixin increased the levels of PPAR-gamma, NQO1, HO-1 and the nuclear translocation of Nrf2 in the kidneys of mice.	bixin	13-18	NAD(P)H dehydrogenase, quinone 1	Mus musculus	55-59
33162346-6	2021	Furthermore, Bixin increased the levels of PPAR-gamma, NQO1, HO-1 and the nuclear translocation of Nrf2 in the kidneys of mice.	bixin	13-18	heme oxygenase 1	Mus musculus	61-65
33162346-6	2021	Furthermore, Bixin increased the levels of PPAR-gamma, NQO1, HO-1 and the nuclear translocation of Nrf2 in the kidneys of mice.	bixin	13-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
33162346-7	2021	Bixin supplementation inhibited the activation of TLR4, MyD88, NF-kappaB, TGF-beta and Smad3.	bixin	0-5	toll-like receptor 4	Mus musculus	50-54
33162346-7	2021	Bixin supplementation inhibited the activation of TLR4, MyD88, NF-kappaB, TGF-beta and Smad3.	bixin	0-5	myeloid differentiation primary response gene 88	Mus musculus	56-61
33162346-7	2021	Bixin supplementation inhibited the activation of TLR4, MyD88, NF-kappaB, TGF-beta and Smad3.	bixin	0-5	transforming growth factor alpha	Mus musculus	74-82
33162346-7	2021	Bixin supplementation inhibited the activation of TLR4, MyD88, NF-kappaB, TGF-beta and Smad3.	bixin	0-5	SMAD family member 3	Mus musculus	87-92
33162346-8	2021	Thus, this study demonstrated that Bixin possesses anti-oxidant, anti-inflammatory and anti-fibrosis properties through regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathways.	bixin	35-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	135-139
33162346-8	2021	Thus, this study demonstrated that Bixin possesses anti-oxidant, anti-inflammatory and anti-fibrosis properties through regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathways.	bixin	35-40	toll-like receptor 4	Mus musculus	140-144
33162346-8	2021	Thus, this study demonstrated that Bixin possesses anti-oxidant, anti-inflammatory and anti-fibrosis properties through regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathways.	bixin	35-40	myeloid differentiation primary response gene 88	Mus musculus	145-150
33162346-8	2021	Thus, this study demonstrated that Bixin possesses anti-oxidant, anti-inflammatory and anti-fibrosis properties through regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathways.	bixin	35-40	peroxisome proliferator activated receptor gamma	Mus musculus	155-165
33162346-8	2021	Thus, this study demonstrated that Bixin possesses anti-oxidant, anti-inflammatory and anti-fibrosis properties through regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathways.	bixin	35-40	transforming growth factor, beta 1	Mus musculus	166-175
33162346-8	2021	Thus, this study demonstrated that Bixin possesses anti-oxidant, anti-inflammatory and anti-fibrosis properties through regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta1/Smad3 pathways.	bixin	35-40	SMAD family member 3	Mus musculus	176-181
33362775-9	2020	Bixin prevented neuroinflammation and demyelination in EAE mice primarily by scavenging ROS through activation of the NRF2 signaling pathway.	bixin	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	118-122
33313043-0	2020	Bixin Protects Against Kidney Interstitial Fibrosis Through Promoting STAT6 Degradation.	bixin	0-5	signal transducer and activator of transcription 6	Mus musculus	70-75
33313043-6	2020	Bixin treatment inhibited STAT6 induction.	bixin	0-5	signal transducer and activator of transcription 6	Mus musculus	26-31
33313043-10	2020	The study demonstrated that bixin can be exploited therapeutically to alleviate renal interstitial fibrosis by targeting STAT6 signaling deactivation.	bixin	28-33	signal transducer and activator of transcription 6	Mus musculus	121-126
32927319-5	2020	Oppositely, pharmacological induction of NRF2 via the apocarotenoid bixin lowered markers of DNA damage and oxidative stress, while preserving viability in irradiated keratinocytes.	bixin	68-73	nuclear factor, erythroid derived 2, like 2	Mus musculus	41-45
33362775-0	2020	Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.	bixin	0-5	thioredoxin interacting protein	Mus musculus	74-79
33362775-0	2020	Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.	bixin	0-5	NLR family, pyrin domain containing 3	Mus musculus	80-85
33362775-0	2020	Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.	bixin	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	123-127
33362775-6	2020	We found that bixin significantly improved the symptoms and pathology in EAE mice, reduced the release of inflammatory cytokines TNF-alpha, IL-6, IL-8, IL-17, and IFN-gamma, and increased the expression of the anti-inflammatory cytokine IL-10.	bixin	14-19	tumor necrosis factor	Mus musculus	129-138
33362775-6	2020	We found that bixin significantly improved the symptoms and pathology in EAE mice, reduced the release of inflammatory cytokines TNF-alpha, IL-6, IL-8, IL-17, and IFN-gamma, and increased the expression of the anti-inflammatory cytokine IL-10.	bixin	14-19	interleukin 6	Mus musculus	140-144
33362775-6	2020	We found that bixin significantly improved the symptoms and pathology in EAE mice, reduced the release of inflammatory cytokines TNF-alpha, IL-6, IL-8, IL-17, and IFN-gamma, and increased the expression of the anti-inflammatory cytokine IL-10.	bixin	14-19	chemokine (C-X-C motif) ligand 15	Mus musculus	146-150
33362775-6	2020	We found that bixin significantly improved the symptoms and pathology in EAE mice, reduced the release of inflammatory cytokines TNF-alpha, IL-6, IL-8, IL-17, and IFN-gamma, and increased the expression of the anti-inflammatory cytokine IL-10.	bixin	14-19	interleukin 17A	Mus musculus	152-157
33362775-6	2020	We found that bixin significantly improved the symptoms and pathology in EAE mice, reduced the release of inflammatory cytokines TNF-alpha, IL-6, IL-8, IL-17, and IFN-gamma, and increased the expression of the anti-inflammatory cytokine IL-10.	bixin	14-19	interferon gamma	Mus musculus	163-172
33362775-6	2020	We found that bixin significantly improved the symptoms and pathology in EAE mice, reduced the release of inflammatory cytokines TNF-alpha, IL-6, IL-8, IL-17, and IFN-gamma, and increased the expression of the anti-inflammatory cytokine IL-10.	bixin	14-19	interleukin 10	Mus musculus	237-242
33362775-7	2020	And bixin reduced the proportion of Th1 and Th17 cells in the spleen and CNS, and suppressed microglia aggregation, and TXNIP/NLRP3 inflammasome activity by scavenging excessive reactive oxygen species (ROS) in EAE mice.	bixin	4-9	thioredoxin interacting protein	Mus musculus	120-125
33362775-7	2020	And bixin reduced the proportion of Th1 and Th17 cells in the spleen and CNS, and suppressed microglia aggregation, and TXNIP/NLRP3 inflammasome activity by scavenging excessive reactive oxygen species (ROS) in EAE mice.	bixin	4-9	NLR family, pyrin domain containing 3	Mus musculus	126-131
33362775-8	2020	Furthermore, bixin inhibited inflammation and oxidative stress via activating nuclear factor erythroid 2-related factor 2 (NRF2), and its downstream genes in EAE mice, meanwhile, these effects were suppressed upon treatment with an NRF2 inhibitor, ML385.	bixin	13-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-121
33362775-8	2020	Furthermore, bixin inhibited inflammation and oxidative stress via activating nuclear factor erythroid 2-related factor 2 (NRF2), and its downstream genes in EAE mice, meanwhile, these effects were suppressed upon treatment with an NRF2 inhibitor, ML385.	bixin	13-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	123-127
32927319-6	2020	Mechanistic studies indicated that topical pretreatment using bixin as an NRF2 activator antagonized initial DNA damage by raising cellular glutathione levels.	bixin	62-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	74-78
32927319-8	2020	Overall, these data indicate that NRF2 is critical for mitigating the harmful skin toxicities associated with ionizing radiation, and that topical upregulation of NRF2 via bixin could prevent radiation-induced dermatitis.	bixin	172-177	nuclear factor, erythroid derived 2, like 2	Mus musculus	163-167
31546267-4	2019	The anti-inflammatory activity of bixin (15 or 30 mg/kg, orally) was determined using carrageenan-induced paw edema and the myeloperoxidase (MPO) activity in male Wistar rats.	bixin	34-39	myeloperoxidase	Rattus norvegicus	124-139
32706966-0	2020	Bixin Confers Prevention against Ureteral Obstruction-Caused Renal Interstitial Fibrosis through Activation of the Nuclear Factor Erythroid-2-Related Factor2 Pathway in Mice.	bixin	0-5	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-157
32706966-2	2020	The nuclear factor erythroid-2-related factor2 (Nrf2) signaling pathway induced by bixin is involved in the process.	bixin	83-88	nuclear factor, erythroid derived 2, like 2	Mus musculus	4-46
32706966-2	2020	The nuclear factor erythroid-2-related factor2 (Nrf2) signaling pathway induced by bixin is involved in the process.	bixin	83-88	nuclear factor, erythroid derived 2, like 2	Mus musculus	48-52
32706966-7	2020	In cultured tubular cells, bixin could induce Nrf2 signaling activation by suppressing Nrf2 ubiquitination and increasing its protein stability.	bixin	27-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	46-50
32706966-7	2020	In cultured tubular cells, bixin could induce Nrf2 signaling activation by suppressing Nrf2 ubiquitination and increasing its protein stability.	bixin	27-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	87-91
32706966-8	2020	Transforming growth factor beta 1-induced epithelial-to-mesenchymal transition (EMT) and extracellular matrix production were suppressed by bixin, and blockade of Nrf2 activation by small interfering RNA could largely reverse the protective effect of bixin.	bixin	140-145	transforming growth factor, beta 1	Mus musculus	0-33
32706966-8	2020	Transforming growth factor beta 1-induced epithelial-to-mesenchymal transition (EMT) and extracellular matrix production were suppressed by bixin, and blockade of Nrf2 activation by small interfering RNA could largely reverse the protective effect of bixin.	bixin	251-256	transforming growth factor, beta 1	Mus musculus	0-33
32706966-8	2020	Transforming growth factor beta 1-induced epithelial-to-mesenchymal transition (EMT) and extracellular matrix production were suppressed by bixin, and blockade of Nrf2 activation by small interfering RNA could largely reverse the protective effect of bixin.	bixin	251-256	nuclear factor, erythroid derived 2, like 2	Mus musculus	163-167
32706966-9	2020	In vivo studies showed that administration of bixin induces Nrf2 signaling activation in tubular cells and markedly attenuates partial EMT of tubular cells and kidney interstitial fibrosis after subjecting to UUO.	bixin	46-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	60-64
32706966-10	2020	Together, this study implies that bixin may protect against kidney interstitial fibrosis through stimulating Nrf2 activation in renal tubular cells.	bixin	34-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	109-113
31546267-4	2019	The anti-inflammatory activity of bixin (15 or 30 mg/kg, orally) was determined using carrageenan-induced paw edema and the myeloperoxidase (MPO) activity in male Wistar rats.	bixin	34-39	myeloperoxidase	Rattus norvegicus	141-144
31546267-7	2019	Only the higher dose of bixin significantly decreased the carrageenan-induced paw edema and the MPO activity and increased the latency time in the hot plate.	bixin	24-29	myeloperoxidase	Mus musculus	96-99