PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 32523550-7 2020 In line with the supposed switch to a pro-inflammatory phenotype known as the senescence associated secretory phenotype (SASP), we found that both RS and DS upregulated IL-1beta and released HMGB-1 from the nucleus, while RS also showed IL-6 upregulation. ds 154-156 interleukin 1 alpha Homo sapiens 169-177 32884023-8 2020 Mechanistically, hADSC-Evs treatment suppressed the DS induced rises in NLRP3 inflammasome formation, caspase-1 activation and IL-1beta maturation. ds 19-21 NLR family, pyrin domain containing 3 Mus musculus 72-77 32884023-8 2020 Mechanistically, hADSC-Evs treatment suppressed the DS induced rises in NLRP3 inflammasome formation, caspase-1 activation and IL-1beta maturation. ds 19-21 caspase 1 Mus musculus 102-111 32884023-8 2020 Mechanistically, hADSC-Evs treatment suppressed the DS induced rises in NLRP3 inflammasome formation, caspase-1 activation and IL-1beta maturation. ds 19-21 interleukin 1 alpha Mus musculus 127-135 32874105-7 2020 DS showed significantly larger knee extension with smaller hip adduction and knee internal rotation compared with SS during the FS. ds 0-2 hedgehog interacting protein Homo sapiens 59-62 30612342-10 2020 Reduced zfALFF in the left Crus II in the DS group was significantly positively correlated with Stroop Color and Word scores, while negatively correlated with Trail-Making Test part B scores. ds 42-44 TNF superfamily member 10 Homo sapiens 159-164 32523550-7 2020 In line with the supposed switch to a pro-inflammatory phenotype known as the senescence associated secretory phenotype (SASP), we found that both RS and DS upregulated IL-1beta and released HMGB-1 from the nucleus, while RS also showed IL-6 upregulation. ds 154-156 high mobility group box 1 Homo sapiens 191-197 32523550-7 2020 In line with the supposed switch to a pro-inflammatory phenotype known as the senescence associated secretory phenotype (SASP), we found that both RS and DS upregulated IL-1beta and released HMGB-1 from the nucleus, while RS also showed IL-6 upregulation. ds 154-156 interleukin 6 Homo sapiens 237-241 30660754-10 2019 In addition, chronic MPH enhanced DAT levels in the left DS but not in right side. ds 57-59 solute carrier family 6 member 3 Rattus norvegicus 34-37 32170206-1 2020 Serine racemase (SR) converts the free form of L-serine into D-serine (DS) in the mammalian brain. ds 71-73 serine racemase Homo sapiens 0-15 31869572-4 2020 Physicochemical and antioxidant properties of ALP changed by the chemical modifications, and the type of the substitution group and DS played a decisive role in the antioxidant activity of the derivatives. ds 132-134 C-C motif chemokine ligand 27 Homo sapiens 46-49 31253302-4 2019 On the contrary, the effects of LMW-GS extracted from variety PBW 550 were more strong as indicated by an increase in DDT (2.75 min), DS (3.30 min) and EP (4.20 Wh/kg). ds 134-136 low-molecular-weight glutenin subunit group 5 type III Triticum aestivum 32-38 31407727-6 2019 An increase in the DS of alginates resulted in augmented FGF-2 binding as evidenced by higher frequency and dissipation shifts measured with QCM-D and confirmed with immunostaining. ds 19-21 fibroblast growth factor 2 Rattus norvegicus 57-62 30015110-5 2018 All together, these results suggest that DS may be a specific subgroup of schizophrenia with the characteristic abnormality of peripheral CXCL1 DNA methylation and gene expression. ds 41-43 C-X-C motif chemokine ligand 1 Homo sapiens 138-143 30362711-6 2018 Subsequently, mRS will specifically recognize overexpressed MRP1 mRNA, leading to the release of trapped DS and followed by AuNP-quenched Cy5 fluorescence recovery. ds 105-107 ATP binding cassette subfamily B member 1 Homo sapiens 60-64 30055879-8 2018 RESULTS: The PR-L4, PR-L5 and PR-S1 in the DS group were significantly smaller than those in the LSS group. ds 43-45 submaxillary gland androgen regulated protein 3A Homo sapiens 20-25 30326694-10 2019 SAF demonstrated a positive relationship with DS at L3-4 (p<0.001) but not at L3-4 or L5-S1. ds 46-48 ribosomal protein L34 Homo sapiens 52-56 30096001-3 2019 CD4+ T cells isolated from DS-exposed mice were transferred to athymic recipient mice. ds 27-29 CD4 antigen Mus musculus 0-3 30096001-7 2019 CD4+ T cells increased in recipients of DS-exposed mice (p < 0.05) and were lower in recipients of QCT- and RES-treated mice (p < 0.05). ds 40-42 CD4 antigen Mus musculus 0-3 28396686-7 2017 Compared with that in the DS group, SSTR2 expression was lower in the SA group. ds 26-28 somatostatin receptor 2 Homo sapiens 36-41 29356175-5 2018 Our results indicated that administration with DS could ameliorate 60 Co-irradiation induced damage and significantly increase the number of peripheral blood cells (white blood cells and platelets), 5 types of hematopoietic progenitor cells CFU (CFU-GM, CFU-E, BFU-E, CFU-Meg, and CFU-GEMM), hematopoietic stem cell (Lin- c-kit+ Scal-1+ ) numbers, and CFUs in the spleen, as well as improved bone marrow histopathology. ds 47-49 KIT proto-oncogene receptor tyrosine kinase Mus musculus 322-327 28887013-10 2017 An increased frequency of rearing was observed in the M, DS, and DM groups from P16 to P20. ds 57-59 cyclin-dependent kinase inhibitor 2A Rattus norvegicus 80-83 28887013-10 2017 An increased frequency of rearing was observed in the M, DS, and DM groups from P16 to P20. ds 57-59 heat shock protein family B (small) member 6 Rattus norvegicus 87-90 28887013-12 2017 An increase in cerebral cortex NGF levels in the M, DS, and DM groups was observed as well. ds 52-54 nerve growth factor Rattus norvegicus 31-34 28340228-7 2017 In contrast, DS with CDX2 and CK20/villin showed slightly higher sensitivity but much lower specificity. ds 13-15 caudal type homeobox 2 Homo sapiens 21-25 28340228-7 2017 In contrast, DS with CDX2 and CK20/villin showed slightly higher sensitivity but much lower specificity. ds 13-15 keratin 20 Homo sapiens 30-34 29372337-2 2018 Results showed that DS markedly increased the production of H2S and H2O2, the transcript levels and activities of ascorbate peroxidase (APX), glutathione reductase (GR), monodehydroascorbate reductase (MDHAR), and dehydroascorbate reductase (DHAR); malondialdehyde (MDA) content; and electrolyte leakage (EL). ds 20-22 POD1 Triticum aestivum 114-134 29372337-2 2018 Results showed that DS markedly increased the production of H2S and H2O2, the transcript levels and activities of ascorbate peroxidase (APX), glutathione reductase (GR), monodehydroascorbate reductase (MDHAR), and dehydroascorbate reductase (DHAR); malondialdehyde (MDA) content; and electrolyte leakage (EL). ds 20-22 POD1 Triticum aestivum 136-139 29372337-2 2018 Results showed that DS markedly increased the production of H2S and H2O2, the transcript levels and activities of ascorbate peroxidase (APX), glutathione reductase (GR), monodehydroascorbate reductase (MDHAR), and dehydroascorbate reductase (DHAR); malondialdehyde (MDA) content; and electrolyte leakage (EL). ds 20-22 probable glutathione S-transferase DHAR1, cytosolic Triticum aestivum 174-200 29372337-2 2018 Results showed that DS markedly increased the production of H2S and H2O2, the transcript levels and activities of ascorbate peroxidase (APX), glutathione reductase (GR), monodehydroascorbate reductase (MDHAR), and dehydroascorbate reductase (DHAR); malondialdehyde (MDA) content; and electrolyte leakage (EL). ds 20-22 probable glutathione S-transferase DHAR1, cytosolic Triticum aestivum 203-207 29292142-4 2018 Thirdly, it was found that the conjugate degree of the dextrin-uricase conjugate was positively related to the DS of dextrin monosuccinate, but the activity was seriously lost and difficult to recover by alpha-amylase. ds 111-113 urate oxidase (pseudogene) Homo sapiens 63-70 29258877-6 2018 On the contrary, our results showed that SS and DS fractions both contain soluble and membrane AChE and the latter has considerably higher activity. ds 48-50 acetylcholinesterase 2 Apis mellifera 95-99 29320844-3 2017 A recent study described 5 different patterns of demyelinating disease presentation, characterised by specific clinical, laboratory and brain and spine magnetic resonance imaging abnormalities: 1) neuromyelitis optica; 2) neuromyelitis optica spectrum disorders; 3) DS prevalently involving the brain; 4) DS prevalently involving the brainstem; 5) clinically isolated syndrome. ds 266-268 POU class 3 homeobox 4 Homo sapiens 295-303 27943017-7 2017 Moreover, in 49 patients, the first CEA value available at the time of DS (1.5 ng/mL; IQR 1.2-2.1) and that at a time without DS (1.6 ng/mL; IQR 1.1-2.3) did not differ significantly (P = 0.397). ds 71-73 CEA cell adhesion molecule 3 Homo sapiens 36-39 26011648-5 2016 Compared with HELP, DS led to significantly greater reductions in total cholesterol (-63.3% vs. -59.9%; P = 0.05), LDL-C (-70.5% vs. -63.0%; P = 0.02), CRP (-75.3% vs. -48.8%; P < 0.0001), and TNF-alpha (-23.7% vs. +14.7%; P = 0.003). ds 20-22 component of oligomeric golgi complex 2 Homo sapiens 115-120 27400260-7 2016 The comparison of enzymatic activity of SOD encapsulated in DS of various configurations (including the systems containing different peptidase inhibitors) was made. ds 60-62 superoxide dismutase 1 Homo sapiens 40-43 26011648-5 2016 Compared with HELP, DS led to significantly greater reductions in total cholesterol (-63.3% vs. -59.9%; P = 0.05), LDL-C (-70.5% vs. -63.0%; P = 0.02), CRP (-75.3% vs. -48.8%; P < 0.0001), and TNF-alpha (-23.7% vs. +14.7%; P = 0.003). ds 20-22 C-reactive protein Homo sapiens 152-155 26011648-5 2016 Compared with HELP, DS led to significantly greater reductions in total cholesterol (-63.3% vs. -59.9%; P = 0.05), LDL-C (-70.5% vs. -63.0%; P = 0.02), CRP (-75.3% vs. -48.8%; P < 0.0001), and TNF-alpha (-23.7% vs. +14.7%; P = 0.003). ds 20-22 tumor necrosis factor Homo sapiens 196-205 25730739-5 2015 Other specialized instruments such as Ligasure, Ultracision, Clip applicators, endobags, and staplers were found to have higher DS. ds 128-130 CAP-Gly domain containing linker protein 1 Homo sapiens 61-65 26402788-7 2016 FA-CAX-1 and FA-CAX-2 contained different amount of FA, with DS at 0.33 and 1.25, respectively, can absorb UV both at UVA and UVB. ds 61-63 calcium exchanger 1 Zea mays 3-8 27222213-5 2016 The adhesive interactions of CS/DS NPs with mucin were not significantly different from those of CS/sodium triphosphate pentabasic (TPP) NPs; however, CS/DS NPs exhibited 5 times greater mucoadhesive activity to buccal cells compared to control CS/TPP NPs in ex vivo adhesion tests. ds 32-34 LOC100508689 Homo sapiens 44-49 24721664-6 2014 For the membrane scaled using DAP as DS, 80-90% of the original flux was recovered when the crossflow velocity for physical cleaning was the same as the crossflow velocity during FDFO desalination. ds 37-39 death associated protein Homo sapiens 30-33 26148195-4 2015 DS are associated with membrane depolarization of granule cells, increased activity of hilar interneurons and suppression of CA3 and CA1 pyramidal cell firing. ds 0-2 carbonic anhydrase 3 Rattus norvegicus 125-128 26148195-4 2015 DS are associated with membrane depolarization of granule cells, increased activity of hilar interneurons and suppression of CA3 and CA1 pyramidal cell firing. ds 0-2 carbonic anhydrase 1 Rattus norvegicus 133-136 25582807-8 2015 Although not affecting baseline levels, DS augmented the exercise-induced redeployment of CD8(+) T-cells, with the naive/early differentiated subtypes (KLRG1(-)/CD45RA(+)) being affected most. ds 40-42 CD8a molecule Homo sapiens 90-93 25832347-7 2015 The expression of alpha-smooth muscle actin was strong in the lower DS and it was also detected in some DP cells. ds 68-70 actin gamma 2, smooth muscle Rattus norvegicus 18-43 25288568-7 2014 Additionally, DS increased the expression of NKG2D in the conjunctiva. ds 14-16 killer cell lectin-like receptor subfamily K, member 1 Mus musculus 45-50 25256343-7 2014 In addition to regulating Dachs, FbxL7 also influences Ds in a similar manner. ds 55-57 F-box and leucine-rich repeat protein 7 Drosophila melanogaster 33-38 24051227-7 2013 Ectopic Ds signaling provides evidence for a model whereby Ds acts to asymmetrically enrich Fat in a neighboring cell, in turn polarizing the cell to specify the position of the actin-based protrusions at the cell cortex. ds 8-10 fat Drosophila melanogaster 92-95 24365705-7 2014 Moreover, micelles with the lowest DS exhibited the highest degree of cellular uptake, which indicated that the micelles were internalized into cells via CD44 receptor-mediated endocytosis and the carboxylic groups of HA are the active binding sites for CD44 receptors. ds 35-37 CD44 molecule (Indian blood group) Homo sapiens 154-158 24365705-7 2014 Moreover, micelles with the lowest DS exhibited the highest degree of cellular uptake, which indicated that the micelles were internalized into cells via CD44 receptor-mediated endocytosis and the carboxylic groups of HA are the active binding sites for CD44 receptors. ds 35-37 CD44 molecule (Indian blood group) Homo sapiens 254-258 24322055-2 2014 We previously demonstrated that direct injection of basic fibroblast growth factor (bFGF) into the hypertensive Dahl salt-sensitive (DS) rat heart prevented systolic dysfunction and left ventricular dilation effectively. ds 133-135 fibroblast growth factor 2 Rattus norvegicus 52-82 24322055-2 2014 We previously demonstrated that direct injection of basic fibroblast growth factor (bFGF) into the hypertensive Dahl salt-sensitive (DS) rat heart prevented systolic dysfunction and left ventricular dilation effectively. ds 133-135 fibroblast growth factor 2 Rattus norvegicus 84-88 24322055-6 2014 CFs harvested from the hearts of noninjected DS rats demonstrated a significantly increased messenger RNA (mRNA) expression of matrix metalloproteinase (MMP)-2, MMP-9, and both collagen I and III. ds 45-47 matrix metallopeptidase 2 Rattus norvegicus 127-159 24322055-6 2014 CFs harvested from the hearts of noninjected DS rats demonstrated a significantly increased messenger RNA (mRNA) expression of matrix metalloproteinase (MMP)-2, MMP-9, and both collagen I and III. ds 45-47 matrix metallopeptidase 9 Rattus norvegicus 161-166 24018763-16 2014 CONCLUSIONS: Compared to gastric bypass, DS results in greater weight loss and improves insulin sensitivity and glucose homeostasis without causing a hyperinsulinemic response. ds 41-43 insulin Homo sapiens 88-95 24326668-10 2014 Overexpression of Hs3st1 in MST-10H cells resulted in a change in the composition of heparan sulfate (HS)/HP and CS/dermatan sulfate (DS) glycosaminoglycans. ds 134-136 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 Mus musculus 18-24 24315969-3 2014 In this study, we found that topical IFN-gamma neutralization significantly decreased DS-induced conjunctival GC loss. ds 86-88 interferon gamma Mus musculus 37-46 24051227-7 2013 Ectopic Ds signaling provides evidence for a model whereby Ds acts to asymmetrically enrich Fat in a neighboring cell, in turn polarizing the cell to specify the position of the actin-based protrusions at the cell cortex. ds 59-61 fat Drosophila melanogaster 92-95 22198289-4 2012 Moreover, the p38 in HUVEC was phosphorylated by DS released from PMN and also by H(2)O(2), but not by O(2) (-) induced by myeloperoxidase (MPO) of PMN. ds 49-51 mitogen-activated protein kinase 14 Homo sapiens 14-17 23368452-3 2012 We show that the CS and DS components of u(x) + d(x) can be extracted by using recent data on the strangeness parton distribution, the CT10 global fit, and the lattice result of the ratio of the strange to u(d) moments in the disconnected insertion. ds 24-26 MAGE family member C2 Homo sapiens 135-139 22684853-16 2012 In comparison, at 6 months following surgery, DS causes a much lower rise in 1-h insulin, with this difference being statistically significant at p < .05. ds 46-48 insulin Homo sapiens 81-88 23583596-6 2013 After 7 days of treatment, western blotting and RT-PCR analyses indicated that the cells cultured with Ds extracts had significantly higher expression of glial fibrillary acidic protein (GFAP), Sox10, Oct6, and early growth response 2(Egr2) than that of cells cultured with Ps extracts and the untreated cells. ds 103-105 glial fibrillary acidic protein Rattus norvegicus 154-185 23583596-6 2013 After 7 days of treatment, western blotting and RT-PCR analyses indicated that the cells cultured with Ds extracts had significantly higher expression of glial fibrillary acidic protein (GFAP), Sox10, Oct6, and early growth response 2(Egr2) than that of cells cultured with Ps extracts and the untreated cells. ds 103-105 glial fibrillary acidic protein Rattus norvegicus 187-191 23583596-6 2013 After 7 days of treatment, western blotting and RT-PCR analyses indicated that the cells cultured with Ds extracts had significantly higher expression of glial fibrillary acidic protein (GFAP), Sox10, Oct6, and early growth response 2(Egr2) than that of cells cultured with Ps extracts and the untreated cells. ds 103-105 SRY-box transcription factor 10 Rattus norvegicus 194-199 23583596-6 2013 After 7 days of treatment, western blotting and RT-PCR analyses indicated that the cells cultured with Ds extracts had significantly higher expression of glial fibrillary acidic protein (GFAP), Sox10, Oct6, and early growth response 2(Egr2) than that of cells cultured with Ps extracts and the untreated cells. ds 103-105 POU class 3 homeobox 1 Rattus norvegicus 201-205 23583596-6 2013 After 7 days of treatment, western blotting and RT-PCR analyses indicated that the cells cultured with Ds extracts had significantly higher expression of glial fibrillary acidic protein (GFAP), Sox10, Oct6, and early growth response 2(Egr2) than that of cells cultured with Ps extracts and the untreated cells. ds 103-105 early growth response 2 Rattus norvegicus 235-239 23645765-8 2013 KRAS mutant-type was detected by DS in 47 out of 100 samples (47.0%), and by HRMA in 45 out of 99 samples (45.5%). ds 33-35 KRAS proto-oncogene, GTPase Homo sapiens 0-4 23483646-3 2013 RESULTS: Mutations in the EGFR gene were detected in 38 of the 61 patients (62%) by DS, 35 (57%) by PNA clamping and 37 (61%) by pyrosequencing. ds 84-86 epidermal growth factor receptor Homo sapiens 26-30 23339583-7 2013 CONCLUSION: Reduced H-FABP level during aging in DS may play a protective role against atherosclerosis. ds 49-51 fatty acid binding protein 3 Homo sapiens 20-26 22986296-16 2012 CONCLUSION: Injection of ds miR-210 was effective in promoting the healing of partially torn ACLs through enhancement of angiogenesis via upregulation of VEGF and FGF2. ds 25-27 microRNA 210 Rattus norvegicus 28-35 22986296-16 2012 CONCLUSION: Injection of ds miR-210 was effective in promoting the healing of partially torn ACLs through enhancement of angiogenesis via upregulation of VEGF and FGF2. ds 25-27 vascular endothelial growth factor A Rattus norvegicus 154-158 22986296-16 2012 CONCLUSION: Injection of ds miR-210 was effective in promoting the healing of partially torn ACLs through enhancement of angiogenesis via upregulation of VEGF and FGF2. ds 25-27 fibroblast growth factor 2 Rattus norvegicus 163-167 22198289-5 2012 On the other hand, caspase 8 in HUVEC was activated by DS, but not by H(2)O(2) and/or O(2) (-). ds 55-57 caspase 8 Homo sapiens 19-28 22198289-7 2012 DS was concentrated, analyzed by electrophoresis, and revealed to contain precursor and subunits of MPO (90, 60, and 14 kDa) and another peptide with a molecular weight of about 28 kDa. ds 0-2 myeloperoxidase Homo sapiens 100-103 22230470-6 2012 The effects of DS on the activities of Nrf2 and NF-kappaB were assessed by western blotting, semi-quantitative RT-PCR, and luciferase reporter assays in RAW 264.7, an NF-kappaB reporter cell line, and HEK 293 transfected with an NF-kappaB reporter construct. ds 15-17 nuclear factor, erythroid derived 2, like 2 Mus musculus 39-43 22230470-6 2012 The effects of DS on the activities of Nrf2 and NF-kappaB were assessed by western blotting, semi-quantitative RT-PCR, and luciferase reporter assays in RAW 264.7, an NF-kappaB reporter cell line, and HEK 293 transfected with an NF-kappaB reporter construct. ds 15-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 48-57 22230470-11 2012 Furthermore, DS enhanced the expression of HO-1 and suppressed that of IL-1beta and TNF-alpha in inflamed mouse lungs. ds 13-15 heme oxygenase 1 Mus musculus 43-47 22230470-11 2012 Furthermore, DS enhanced the expression of HO-1 and suppressed that of IL-1beta and TNF-alpha in inflamed mouse lungs. ds 13-15 interleukin 1 beta Mus musculus 71-79 21885053-6 2011 The surface charge of PHL associated with PAsn-g-C(22) was changed by DS of alkyl chains. ds 70-72 BCR activator of RhoGEF and GTPase Homo sapiens 22-25 22230470-11 2012 Furthermore, DS enhanced the expression of HO-1 and suppressed that of IL-1beta and TNF-alpha in inflamed mouse lungs. ds 13-15 tumor necrosis factor Mus musculus 84-93 22230470-12 2012 CONCLUSIONS: These results suggest that the therapeutic effects of DS are related with suppression of inflammation, which is, at least in part, mediated by activation of anti-inflammatory factor Nrf2 and inhibition of pro-inflammatory factor NF-kappaB. ds 67-69 nuclear factor, erythroid derived 2, like 2 Mus musculus 195-199 22230470-12 2012 CONCLUSIONS: These results suggest that the therapeutic effects of DS are related with suppression of inflammation, which is, at least in part, mediated by activation of anti-inflammatory factor Nrf2 and inhibition of pro-inflammatory factor NF-kappaB. ds 67-69 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 242-251 21902464-5 2012 We found that collagen DS released in vitro about 35% of its BMP-9 within 1 h, whereas chitosan DS released 80%. ds 23-25 growth differentiation factor 2 Mus musculus 61-66 21474767-9 2011 DS-induced conjunctival apoptosis was greatest in the goblet cell area and was accompanied by a decrease in MUC5AC expression in the B6 and B6-IFN-gamma-injected groups compared with the B6gammaKO and B6-BSA-injected groups. ds 0-2 mucin 5, subtypes A and C, tracheobronchial/gastric Mus musculus 108-114 21843497-5 2011 The activation of caspase-8 mediated increased corneal epithelial apoptosis in B6 mice after DS, and this was exacerbated by subconjunctival IFN-gamma injection. ds 93-95 caspase 8 Mus musculus 18-27 21843497-7 2011 Adoptive transfer of CD4(+) T cells from donors subjected to DS increased corneal epithelial apoptosis via activation of caspase-8 in recipients, similar to that in the donor mice. ds 61-63 CD4 antigen Mus musculus 21-24 21843497-7 2011 Adoptive transfer of CD4(+) T cells from donors subjected to DS increased corneal epithelial apoptosis via activation of caspase-8 in recipients, similar to that in the donor mice. ds 61-63 caspase 8 Homo sapiens 121-130 20926348-8 2011 RESULTS: The VUR resolution/improvement rate was 88% in DS and 95% in SS patients. ds 56-58 VUR Homo sapiens 13-16 21474767-9 2011 DS-induced conjunctival apoptosis was greatest in the goblet cell area and was accompanied by a decrease in MUC5AC expression in the B6 and B6-IFN-gamma-injected groups compared with the B6gammaKO and B6-BSA-injected groups. ds 0-2 interferon gamma Mus musculus 143-152 21474767-12 2011 CONCLUSIONS: IFN-gamma plays a pivotal role in exacerbating conjunctival apoptosis through dual apoptotic pathways with DS. ds 120-122 interferon gamma Mus musculus 13-22 21423636-5 2011 DS (10-300 mug/mL) produced a concentration-dependent relaxation in mouse aorta, which was significantly attenuated by the nitric oxide synthase (NOS) inhibitor L-NAME, suggesting that DS causes vasodilation via a NO-dependent mechanism. ds 0-2 nitric oxide synthase 1, neuronal Mus musculus 123-144 21423636-5 2011 DS (10-300 mug/mL) produced a concentration-dependent relaxation in mouse aorta, which was significantly attenuated by the nitric oxide synthase (NOS) inhibitor L-NAME, suggesting that DS causes vasodilation via a NO-dependent mechanism. ds 185-187 nitric oxide synthase 1, neuronal Mus musculus 123-144 22194977-5 2011 METHODOLOGY/PRINCIPAL FINDINGS: DS was induced by subcutaneous injection of scopolamine and exposure to a drafty low humidity environment in CD4-DNTGFbetaRII and wild-type (WT) mice, aged 14 weeks, for 5 days. ds 32-34 CD4 antigen Mus musculus 141-144 20072060-6 2010 STh and VO2Th during DP and VO2Th during DS were correlated with the level of performance (r = -0.88, p < 0.001; r = -0.63, p < 0.05; and r = -0.65, p < 0.05, respectively). ds 41-43 saitohin Homo sapiens 0-3 20434335-7 2010 We demonstrate that Fj both promotes the ability of Fat to bind to its ligand Ds and inhibits the ability of Ds to bind Fat. ds 78-80 FAT atypical cadherin 1 Homo sapiens 52-55 20434335-8 2010 Consequently, the juxtaposition of cells with differing Fj expression results in asymmetric Fat:Ds binding. ds 96-98 FAT atypical cadherin 1 Homo sapiens 92-95 18369389-3 2008 The ds oligos were inserted into the pENTR/H1/TO vector and transfected into MN9D dopaminergic cells. ds 4-6 ceramide synthase 1 Mus musculus 37-48 18833000-4 2008 The sctb ds[19 x 16 x 19] also used ds components and displayed 3-fold greater avidity for CD19 than the bsscFv (KD = 13 vs. 42 nM), whereas both had equal affinity for CD16 (KD = 58 nM). ds 9-11 CD19 molecule Homo sapiens 91-95 16221981-6 2005 In DS, there was a transient decrease in glucocorticoid receptor (GR) mRNA in the paraventricular nucleus (PVN) and pituitary and a transient increase in corticotrophin-releasing hormone (CRH) mRNA. ds 3-5 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 41-64 17704297-8 2007 We detected an association between development of DS and the AA genotype at Codon 469 of ICAM-1 (odds ratio of 3.5; 95% confidence interval: 1.2-10.2). ds 50-52 intercellular adhesion molecule 1 Homo sapiens 89-95 16859743-3 2006 This indicates that for e.g. a DS of 28, 9 out of the 32 hydroxyl groups of a HyPG molecule were esterified with methacryloyl groups. ds 31-33 ubiquitin conjugating enzyme E2 K Homo sapiens 78-82 16491129-6 2006 PD2 is a modular protein composed of RNA recognition motif, DEAD-boxes, an aspartic/serine (DS)-domain, a regulator of the chromosome condensation domain and myc-type helix-loop-helix domains. ds 92-94 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 0-3 16547229-6 2006 The results suggest that DS exposes shared epitopes in the cornea, conjunctiva, and LG that induce pathogenic CD4(+) T cells that produce LKC, which under normal circumstances is restrained by CD4(+)CD25(+)forkhead/winged helix transcription factor(+) regulatory T cells. ds 25-27 CD4 antigen Mus musculus 110-113 16547229-6 2006 The results suggest that DS exposes shared epitopes in the cornea, conjunctiva, and LG that induce pathogenic CD4(+) T cells that produce LKC, which under normal circumstances is restrained by CD4(+)CD25(+)forkhead/winged helix transcription factor(+) regulatory T cells. ds 25-27 CD4 antigen Mus musculus 193-196 16344366-8 2006 Vehicle-treated DS developed hypertension (SBP 168+/-5 mm Hg), left ventricular hypertrophy (LVH), proteinuria, impaired EDR, and increased aortic ROS production (superoxide 115% and peroxynitrite 157%) and expression of the proatherogenic molecules LOX-1 (130%) and MCP-1 (166%). ds 16-18 oxidized low density lipoprotein receptor 1 Rattus norvegicus 250-255 16344366-8 2006 Vehicle-treated DS developed hypertension (SBP 168+/-5 mm Hg), left ventricular hypertrophy (LVH), proteinuria, impaired EDR, and increased aortic ROS production (superoxide 115% and peroxynitrite 157%) and expression of the proatherogenic molecules LOX-1 (130%) and MCP-1 (166%). ds 16-18 mast cell protease 1-like 1 Rattus norvegicus 267-272 17991790-7 2008 While resting end-tidal Pco(2) (Pet(CO(2))) increased with DS, the change in Pet(CO(2)) from rest to exercise was not increased, indicating that increased chemoreceptor feedback from rest to exercise cannot account for the greater exercise ventilatory response. ds 59-61 complement C2 Homo sapiens 32-42 17718201-5 2007 Heptakis(2,6-di-O-methyl)-beta-CD (DIMEB) with a degree of substitution (DS) of 14 has two methyl groups in all of the seven glucose subunits mostly at O-2 and O-6 position, each OH group is methylated in heptakis(2,3,6-tri-O-methyl)-beta-CD (TRIMEB) (DS = 21), and an unsystematic substitution is realized in randomly methylated beta-CD (RAMEB). ds 73-75 beta-carotene oxygenase 1 Mus musculus 26-33 16858610-6 2006 Sulfite treatment caused a decrease of NR2A and NR2B subunits of the NMDAR in hippocampus of rats in S and DS groups. ds 107-109 glutamate ionotropic receptor NMDA type subunit 2A Rattus norvegicus 39-43 16858610-6 2006 Sulfite treatment caused a decrease of NR2A and NR2B subunits of the NMDAR in hippocampus of rats in S and DS groups. ds 107-109 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 48-52 16150492-18 2006 Additionally, the reduction of all VEP latencies in the DSE group with respect to the DS group clearly indicated that vitamin E has the potential to prevent sulfite induced-VEP changes arising from dysfunction of the SOX enzyme. ds 56-58 sulfite oxidase Rattus norvegicus 217-220 16221981-6 2005 In DS, there was a transient decrease in glucocorticoid receptor (GR) mRNA in the paraventricular nucleus (PVN) and pituitary and a transient increase in corticotrophin-releasing hormone (CRH) mRNA. ds 3-5 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 66-68 16221981-6 2005 In DS, there was a transient decrease in glucocorticoid receptor (GR) mRNA in the paraventricular nucleus (PVN) and pituitary and a transient increase in corticotrophin-releasing hormone (CRH) mRNA. ds 3-5 corticotropin releasing hormone Rattus norvegicus 154-186 16221981-6 2005 In DS, there was a transient decrease in glucocorticoid receptor (GR) mRNA in the paraventricular nucleus (PVN) and pituitary and a transient increase in corticotrophin-releasing hormone (CRH) mRNA. ds 3-5 corticotropin releasing hormone Rattus norvegicus 188-191 15191539-4 2004 Immunohistology demonstrated expression of MSP receptor RON in the outer and inner root sheaths, hair matrix cells, DP, and bulbar DS whereas non-follicular epithelium and some cells of the sweat glands exhibited low-level receptor expression. ds 131-133 macrophage stimulating 1 Homo sapiens 43-46 15738791-8 2005 CONCLUSIONS: These findings suggest that the higher expression of estrogen receptor might aggravate degenerative change of the facet articular cartilage and might also be considered one of the causative factors for DS in postmenopausal women. ds 215-217 estrogen receptor 1 Homo sapiens 66-83 15373764-6 2004 One such gene, the WNT-signalling modulator Wise, was expressed in the DP and not in the non-inductive DS and was additionally expressed at high levels in the precortex and in the putative bulge region. ds 103-105 Wnt family member 2 Rattus norvegicus 19-22 15506055-12 2004 NKCC2 hyperactivity of prehypertensive DS is therefore not due to a deficient NOS. ds 39-41 solute carrier family 12 member 1 Rattus norvegicus 0-5 16099413-5 2005 IFN-gamma was significantly elevated at day 7 in mice receiving only the AdV vector compared to the AdV vector formulated with DS/DOPE, DC-Chol/DOPE, or dexamethasone. ds 127-129 interferon gamma Mus musculus 0-9 15821569-14 2005 The likelihood of undergoing surgery was the same for low grade VUR (I and II) in the DS and SS groups (p = 0.16). ds 86-88 VUR Homo sapiens 64-67 15831365-10 2005 The APA immunostaining in DS-8% rats was enhanced in glomeruli displaying mild damage, diminished in the severely injured glomeruli, and absent in lesions with hyalinization. ds 26-28 glutamyl aminopeptidase Rattus norvegicus 4-7 15775788-7 2005 Hypertensive DS rats showed increased nNOS activity in the brainstem, but not in the diencephalon or cerebellum. ds 13-15 nitric oxide synthase 1 Rattus norvegicus 38-42 15775788-10 2005 The number of nNOS neurons in these nuclei, except for the two raphes, was significantly greater in hypertensive than in normotensive DS rats. ds 134-136 nitric oxide synthase 1 Rattus norvegicus 14-18 15261584-8 2004 Since the size effect is small, a classification of CMCs as low-, middle-, or high MM will be sufficient to obtain accurate data on the DS distribution. ds 136-138 G protein signaling modulator 2 Homo sapiens 52-56 14724671-5 2004 DS retains partial corticosteroid character as quantified by the rapid translocation of glucocorticoid receptor to the nucleus and by dose-dependent transactivation from a glucocorticoid response element. ds 0-2 nuclear receptor subfamily 3, group C, member 1 Mus musculus 88-111 11253171-8 2001 On comparing with old male rats, old female rats showed increase in AChE activity in cerebral cortex, hippocampus and hypothalamus of DS fraction and decrease in hypothalamus of SS fraction. ds 134-136 acetylcholinesterase Rattus norvegicus 68-72 12805203-4 2003 Here, we describe the cocrystal structures of the NR1 S1S2 ligand-binding core with the agonists glycine and D-serine (DS), the partial agonist D-cycloserine (DCS) and the antagonist 5,7-dichlorokynurenic acid (DCKA). ds 119-121 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 50-53 12612383-9 2003 The post-procedural median (IQR) peak cTnI concentrations were 0.2 0.1 g/L in the DS group and 0.5 0.3 g/L in the PD group (p = 0.02). ds 85-87 troponin I3, cardiac type Homo sapiens 38-42 12612383-10 2003 Post-procedural cTnI concentrations were > 0.2 g/L in 11 patients (10%) in the DS group and in 53 patients (26%) in the PD group (X2 = 58.6; p < 0.0001). ds 83-85 troponin I3, cardiac type Homo sapiens 16-20 11923567-7 2002 Although the incidence of cTnT was elevated in 4 of 37 patients (10.8%) in the DS group and in 5 out of 23 patients (21.7%) in the CS group at 16 hours post-procedure, these values did not reach statistical significance (p > 0.05). ds 79-81 troponin T2, cardiac type Homo sapiens 26-30 14757640-8 2004 We show that fj interacts genetically with ft and ds in planar polarity and proximodistal patterning. ds 50-52 four-jointed Drosophila melanogaster 13-15 14699494-8 2004 In Caco-2 cells, while EGF stimulated BB NHE3, Akt2 was active in both LR and DS pools. ds 78-80 AKT serine/threonine kinase 2 Homo sapiens 47-51 12746046-10 2003 The P(v), DS, and A(i) increased/decreased with the rise/fall of the Ptp; A(i) was the only variable to display statistically significant values (P<.05) when the Ptp was modified. ds 10-12 protein tyrosine phosphatase, non-receptor type 13 Rattus norvegicus 69-72 11882630-11 2002 The adhesion molecules VCAM-1 and PECAM-1, and the antiapoptotic molecule xIAP were upregulated in the left ventricle of the heart of DS rats and downregulated in the rats treated with the ET(A) antagonist. ds 134-136 vascular cell adhesion molecule 1 Rattus norvegicus 23-29 11882630-11 2002 The adhesion molecules VCAM-1 and PECAM-1, and the antiapoptotic molecule xIAP were upregulated in the left ventricle of the heart of DS rats and downregulated in the rats treated with the ET(A) antagonist. ds 134-136 platelet and endothelial cell adhesion molecule 1 Rattus norvegicus 34-41 11882630-11 2002 The adhesion molecules VCAM-1 and PECAM-1, and the antiapoptotic molecule xIAP were upregulated in the left ventricle of the heart of DS rats and downregulated in the rats treated with the ET(A) antagonist. ds 134-136 X-linked inhibitor of apoptosis Rattus norvegicus 74-78 11253171-9 2001 There was a significant increase in AChE activity in DS fraction of cerebral cortex, hippocampus, hypothalamus, thalamus and cerebellum in female as compared to male adult rats. ds 53-55 acetylcholinesterase Rattus norvegicus 36-40 11253171-11 2001 Thus it appears that age alters AChE activity in different brain regions predominantly in DS fraction (G4 isoform) that may vary in male and female. ds 90-92 acetylcholinesterase Rattus norvegicus 32-36 10728880-11 2000 In conclusion, under the present conditions, D2 receptors are principally implicated in the DS properties of PD128,907 and 7-OH-DPAT. ds 92-94 immunoglobulin heavy diversity 2-15 Homo sapiens 45-47 11783302-4 1999 There were significant differences between the DS group and non-DS group in the invading depth (deeper in DS), metastasis of lymphnode (severer in DS) and TNM stage (later in DS) of esphageal carcinoma, (P < 0.05). ds 47-49 teneurin transmembrane protein 1 Homo sapiens 155-158 10599998-11 1999 The DS phenotype in these conditions is always CD4+ cells weakly expressing CD8 and is a consequence of de novo synthesis of the CD8alpha molecule by the CD4+ cells. ds 4-6 CD4 molecule Homo sapiens 47-50 10599998-11 1999 The DS phenotype in these conditions is always CD4+ cells weakly expressing CD8 and is a consequence of de novo synthesis of the CD8alpha molecule by the CD4+ cells. ds 4-6 CD8a molecule Homo sapiens 76-79 10599998-11 1999 The DS phenotype in these conditions is always CD4+ cells weakly expressing CD8 and is a consequence of de novo synthesis of the CD8alpha molecule by the CD4+ cells. ds 4-6 CD8a molecule Homo sapiens 129-137 10599998-11 1999 The DS phenotype in these conditions is always CD4+ cells weakly expressing CD8 and is a consequence of de novo synthesis of the CD8alpha molecule by the CD4+ cells. ds 4-6 CD4 molecule Homo sapiens 154-157 10051633-7 1999 The ds nucleic acids also induce or activate Stat1, Stat3, mitogen-activated protein kinase, NF-kappaB, the class II transactivator, RFX5, and the IFN regulatory factor 1 differently from gammaIFN. ds 4-6 signal transducer and activator of transcription 1 Homo sapiens 45-50 10051633-7 1999 The ds nucleic acids also induce or activate Stat1, Stat3, mitogen-activated protein kinase, NF-kappaB, the class II transactivator, RFX5, and the IFN regulatory factor 1 differently from gammaIFN. ds 4-6 signal transducer and activator of transcription 3 Homo sapiens 52-57 10051633-7 1999 The ds nucleic acids also induce or activate Stat1, Stat3, mitogen-activated protein kinase, NF-kappaB, the class II transactivator, RFX5, and the IFN regulatory factor 1 differently from gammaIFN. ds 4-6 nuclear factor kappa B subunit 1 Homo sapiens 93-102 10051633-7 1999 The ds nucleic acids also induce or activate Stat1, Stat3, mitogen-activated protein kinase, NF-kappaB, the class II transactivator, RFX5, and the IFN regulatory factor 1 differently from gammaIFN. ds 4-6 regulatory factor X5 Homo sapiens 133-137 9335602-4 1997 The comb gap (cg) mutation, which also interacts with ds, greatly enhances the tendency of imaginal discs from l(2)gd larvae to duplicate as they overgrow. ds 54-56 combgap Drosophila melanogaster 4-12 10958252-4 1998 Therefore, activation of 5-HT1B receptors located in the DS increases the release of DA in the n. acc, presumably via the glutamatergic projection to this structure and acting through NMDA receptors in it. ds 57-59 5-hydroxytryptamine receptor 1B Rattus norvegicus 25-31 8457895-3 1993 On a poly-D-lysine substrate, the rank ordering of specific neurite growth activity based on protein concentration was 330 kDa HSPG >> 100 kDa HSPG/chondroitin sulphate (CS) PG mixture or hybrid > 330 kDa CSPG > 50 kDa CSPG/dermatan sulphate (DS) PG mixture or hybrid and the 31 kDa sulphoprotein. ds 255-257 glypican 3 Homo sapiens 127-131 9039108-9 1997 Moreover, in DS rats there was a negative correlation between cNOS activity and aortic hypertrophy (r = -.70, P < .01). ds 13-15 nitric oxide synthase 3 Rattus norvegicus 62-66 9068899-3 1997 Analysis of the experimental data obtained for DS, DSS1 and DSS2 was performed using a previously described model which allows computation of the dissociation constant (KPS,HC) of the polysaccharide-HC II complex and the rate constant of thrombin inhibition by the polysaccharide-HC II complex (k). ds 47-49 serpin family D member 1 Homo sapiens 199-204 8741551-13 1996 A significant decrease in DS was observed both in the RIG group and the GR group, in the former from 22.1 +/- 7.2 to 13.1 +/- 9.3, and in the latter from 19.9 +/- 11.5 to 9.1 +/- 9.2 (p < 0.01). ds 26-28 dickkopf WNT signaling pathway inhibitor 3 Homo sapiens 54-57 7665171-6 1995 We speculate that Ds is caused by a mutation in the Gata4 gene, ectopic expression of GATA-4, or a mutation in another lineage determination gene closely linked to Gata4. ds 18-20 GATA binding protein 4 Homo sapiens 52-57 7665171-6 1995 We speculate that Ds is caused by a mutation in the Gata4 gene, ectopic expression of GATA-4, or a mutation in another lineage determination gene closely linked to Gata4. ds 18-20 GATA binding protein 4 Homo sapiens 86-92 7665171-6 1995 We speculate that Ds is caused by a mutation in the Gata4 gene, ectopic expression of GATA-4, or a mutation in another lineage determination gene closely linked to Gata4. ds 18-20 GATA binding protein 4 Homo sapiens 164-169 7552370-7 1995 Specific 5-HT1B binding site density was decreased in the DS on the ipsilateral side of the lesion compared to the contralateral side. ds 58-60 5-hydroxytryptamine receptor 1B Rattus norvegicus 9-15 7965004-3 1994 DS was observed in nonspiking tangential (Tan1) neurons of the distal medulla externa and it is expressed by the amplitude of the modulated synaptic potential elicited with drifting gratings. ds 0-2 notch receptor 1 Homo sapiens 42-46 34688810-13 2022 CONCLUSION: Our findings suggest that functional connectomes, especially SN, SMN, and VN, may capture the distinct and common disruptions of DS and NDS. ds 141-143 survival of motor neuron 1, telomeric Homo sapiens 77-80 34413161-7 2021 BCRP inhibitors also increased the AUC and maximum plasma concentration of DS and ES after co-administration with each parent compound. ds 75-77 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 0-4 34413161-9 2021 ATP-dependent uptake of DS and ES in BCRP-expressing membrane vesicles was reduced by both inhibitors, indicating inhibition of BCRP-mediated DS and ES transport. ds 24-26 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 37-41 34413161-9 2021 ATP-dependent uptake of DS and ES in BCRP-expressing membrane vesicles was reduced by both inhibitors, indicating inhibition of BCRP-mediated DS and ES transport. ds 24-26 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 128-132 34413161-9 2021 ATP-dependent uptake of DS and ES in BCRP-expressing membrane vesicles was reduced by both inhibitors, indicating inhibition of BCRP-mediated DS and ES transport. ds 142-144 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 37-41 34413161-9 2021 ATP-dependent uptake of DS and ES in BCRP-expressing membrane vesicles was reduced by both inhibitors, indicating inhibition of BCRP-mediated DS and ES transport. ds 142-144 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 128-132 34299171-8 2021 In contrast, DS is studied in terms of the Adam-Gibbs model by obtaining the configurational entropy (Sconf) and the specific heat contributions (CP,conf). ds 13-15 ceruloplasmin Homo sapiens 146-148 34629386-14 2022 The improvement in back pain is similar to the improvement in leg pain after surgery for L3-4 spinal stenosis with DS. ds 115-117 ribosomal protein L34 Homo sapiens 89-93 34352715-13 2021 DS treatment groups showed the levels of TNF- alpha was slightly reduced, while IL-1beta and IL-6 levels were significantly reduced (P < 0.05) compared to the oestrogen treated group. ds 0-2 tumor necrosis factor Rattus norvegicus 41-51 34352715-13 2021 DS treatment groups showed the levels of TNF- alpha was slightly reduced, while IL-1beta and IL-6 levels were significantly reduced (P < 0.05) compared to the oestrogen treated group. ds 0-2 interleukin 1 alpha Rattus norvegicus 80-88 34352715-13 2021 DS treatment groups showed the levels of TNF- alpha was slightly reduced, while IL-1beta and IL-6 levels were significantly reduced (P < 0.05) compared to the oestrogen treated group. ds 0-2 interleukin 6 Rattus norvegicus 93-97 34305940-8 2021 Results: DS significantly increased the recruitment of adoptively transferred MHCII positive and negative myeloid cells to the conjunctiva in a CCR2 dependent fashion. ds 9-11 C-C motif chemokine receptor 2 Homo sapiens 144-148 34162415-8 2021 RESULTS: DS significantly alleviated the neuropathic pain by increasing the mechanical withdrawal threshold and inhibiting the activation of NLRP3 in CCI-induced model mice. ds 9-11 NLR family, pyrin domain containing 3 Mus musculus 141-146 34163455-5 2021 Thiosulfate gave the highest denitrification rates removing 10.94 mM NO3 - day-1 and 8.98 mM NO3 - day-1 by DS and GS, respectively. ds 108-110 NBL1, DAN family BMP antagonist Homo sapiens 69-72 34163455-5 2021 Thiosulfate gave the highest denitrification rates removing 10.94 mM NO3 - day-1 and 8.98 mM NO3 - day-1 by DS and GS, respectively. ds 108-110 NBL1, DAN family BMP antagonist Homo sapiens 93-96 34162415-9 2021 Our findings indicated that DS promoted the mitophagy by increasing the LC3II and Beclin 1 and decreasing the levels of p62 protein in BV-2 cell. ds 28-30 beclin 1, autophagy related Mus musculus 82-90 34162415-9 2021 Our findings indicated that DS promoted the mitophagy by increasing the LC3II and Beclin 1 and decreasing the levels of p62 protein in BV-2 cell. ds 28-30 nucleoporin 62 Mus musculus 120-123 34162415-12 2021 CONCLUSION: Together, our findings demonstrated that DS ameliorate chronic neuropathic pain in mice by suppressing NLRP3 inflammasome activation induced by mitophagy in microglia. ds 53-55 NLR family, pyrin domain containing 3 Mus musculus 115-120 2927724-3 1989 The activity of detergent-soluble (DS) AChE in the cerebral cortex and cerebellum was lower in the older rats (24-25 months) rats than in younger (3-4 months) ones. ds 35-37 acetylcholinesterase Rattus norvegicus 39-43 2927724-4 1989 The activity of DS-AChE in the cerebral cortex and cerebellum did not differ between 10- to 11-month-old and 24- to 25-month-old rats. ds 16-18 acetylcholinesterase Rattus norvegicus 19-23 33326808-6 2021 Hyaluronic acid synthase 2 (HAS2) was highly expressed, while matrix metalloproteinase-1 (MMP1) was elevated in the DP and DS in situ. ds 123-125 matrix metallopeptidase 1 Homo sapiens 62-88 33930539-13 2021 DS elicited K14+ epithelial cell displacement, as indicated by increased fluorescence signal at a distance of 50-100 mum radially inwards from the limbus [0.63 +- 0.053% (DS) vs 0.54 +- 0.060% (UT), p = 0.0317]. ds 0-2 keratin 14 Mus musculus 12-15 32249691-5 2021 The theoretically analyzed HP-beta-CD"s degree of substitution (DS) of caffeic and of rosmarinic acids can explain the intensities obtained by 2D NOESY experiments. ds 64-66 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 30-37 2525523-6 1989 DS rats on 8% salt diet developed hypertension, and cardiac output and blood volume increased; glomerular filtration rate, urinary flow, and sodium excretion did not change, despite an increase in ANF. ds 0-2 natriuretic peptide A Rattus norvegicus 197-200 3411326-12 1988 G4a forms of AChE, which are solubilized only in the presence of detergent and aggregate in the absence of detergent, represent a large proportion of cholinesterase in DS extracts of nerves and spinal cord, together with a smaller component of G4a BuChE. ds 168-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 3314316-8 1987 Acid-demineralized DS alone or together with plasma treatment enhanced both the attachment and the growth of HGF. ds 19-21 hepatocyte growth factor Homo sapiens 109-112 2885349-10 1987 The location of NPY-immunoreactive perikarya and nerve terminals in the dorsal subnuclei of the nTS, i.e., the dPSR and ds, is of particular significance, since this distribution corresponds with the location of small adrenergic neurons as well as with the site of termination of aortic and carotid sinus nerve afferent fibers. ds 120-122 neuropeptide Y Rattus norvegicus 16-19 2953508-6 1987 Phosphotungstate-Mg (PTA), heparin-Mn (Hep) and dextran sulfate-Mg (DS) precipitate approximately 95% of serum Lpa together with the Apo B containing lipoproteins. ds 68-70 lipoprotein(a) Homo sapiens 111-114 2953508-6 1987 Phosphotungstate-Mg (PTA), heparin-Mn (Hep) and dextran sulfate-Mg (DS) precipitate approximately 95% of serum Lpa together with the Apo B containing lipoproteins. ds 68-70 apolipoprotein B Homo sapiens 133-138 3582061-6 1987 The intrinsic association constant of the dye to ds RNA (Ki = 6.96 X 10(4), M-1) and to ds DNA (Ki = 1.74 X 10(4), M-1) was measured in 150 mM NaCl; the binding site size was 2-3 base pair for both polymers. ds 49-51 myoregulin Homo sapiens 76-79 6735459-8 1984 VP contributes significantly to the regional hemodynamic abnormalities in skeletal muscles and skin in whole DS rats, and also in several other organs in the responders. ds 109-111 arginine vasopressin Rattus norvegicus 0-2 33326808-6 2021 Hyaluronic acid synthase 2 (HAS2) was highly expressed, while matrix metalloproteinase-1 (MMP1) was elevated in the DP and DS in situ. ds 123-125 matrix metallopeptidase 1 Homo sapiens 90-94 33841208-10 2021 Furthermore, after DS treatment, the ChAT and SOD activities of HLSI rats were increased while AChE activity was significantly suppressed. ds 19-21 choline O-acetyltransferase Rattus norvegicus 37-41 33841208-10 2021 Furthermore, after DS treatment, the ChAT and SOD activities of HLSI rats were increased while AChE activity was significantly suppressed. ds 19-21 acetylcholinesterase Rattus norvegicus 95-99 33414864-6 2020 Greater decreases in oxygenated hemoglobin AUC and hemoglobin differentiated AUC were respectively found for DS (-4036.8 +- 2698.1; -5004.4 +- 2722.9) compared with TRAD (-1951.8 +- 1720.0; -2250.3 +- 1305.7) and CP (-1814.4 +- 2634.3; 2432.2 +- 2891.4) (p<0.03). ds 109-111 ceruloplasmin Homo sapiens 213-215 32431006-5 2020 Treatment with DS significantly upregulated BDNF (brain-derived neurotrophic factor), p-CREB/CREB and p-ERK1/2/ERK1/2 protein expression in the hippocampus and prefrontal cortex of CSDS mice. ds 15-17 brain derived neurotrophic factor Mus musculus 44-48 32431006-5 2020 Treatment with DS significantly upregulated BDNF (brain-derived neurotrophic factor), p-CREB/CREB and p-ERK1/2/ERK1/2 protein expression in the hippocampus and prefrontal cortex of CSDS mice. ds 15-17 brain derived neurotrophic factor Mus musculus 50-83 32431006-5 2020 Treatment with DS significantly upregulated BDNF (brain-derived neurotrophic factor), p-CREB/CREB and p-ERK1/2/ERK1/2 protein expression in the hippocampus and prefrontal cortex of CSDS mice. ds 15-17 cAMP responsive element binding protein 1 Mus musculus 88-92 32431006-5 2020 Treatment with DS significantly upregulated BDNF (brain-derived neurotrophic factor), p-CREB/CREB and p-ERK1/2/ERK1/2 protein expression in the hippocampus and prefrontal cortex of CSDS mice. ds 15-17 cAMP responsive element binding protein 1 Mus musculus 93-97 32431006-5 2020 Treatment with DS significantly upregulated BDNF (brain-derived neurotrophic factor), p-CREB/CREB and p-ERK1/2/ERK1/2 protein expression in the hippocampus and prefrontal cortex of CSDS mice. ds 15-17 mitogen-activated protein kinase 3 Mus musculus 104-110 32431006-5 2020 Treatment with DS significantly upregulated BDNF (brain-derived neurotrophic factor), p-CREB/CREB and p-ERK1/2/ERK1/2 protein expression in the hippocampus and prefrontal cortex of CSDS mice. ds 15-17 mitogen-activated protein kinase 3 Mus musculus 111-117 32431006-6 2020 Collectively, these results suggest that DS exerts anxiolytic-like effects in CSDS model mice and the action is mediated, at least in part, by modulating the HPA (hypothalamic-pituitary-adrenal) axis and monoamine neurotransmitter levels, and via ERK/CREB/BDNF signaling pathway. ds 41-43 mitogen-activated protein kinase 1 Mus musculus 247-250 32431006-6 2020 Collectively, these results suggest that DS exerts anxiolytic-like effects in CSDS model mice and the action is mediated, at least in part, by modulating the HPA (hypothalamic-pituitary-adrenal) axis and monoamine neurotransmitter levels, and via ERK/CREB/BDNF signaling pathway. ds 41-43 cAMP responsive element binding protein 1 Mus musculus 251-255 32431006-6 2020 Collectively, these results suggest that DS exerts anxiolytic-like effects in CSDS model mice and the action is mediated, at least in part, by modulating the HPA (hypothalamic-pituitary-adrenal) axis and monoamine neurotransmitter levels, and via ERK/CREB/BDNF signaling pathway. ds 41-43 brain derived neurotrophic factor Mus musculus 256-260