PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31001094-0	2019	Hop-Derived Iso-alpha-Acids in Beer Improve Visual Discrimination and Reversal Learning in Mice as Assessed by a Touch Panel Operant System.	iso-alpha-acids	12-27	HOP homeobox	Mus musculus	0-3
32193103-1	2020	OBJECTIVE: To elucidate the effects of ISO-alpha-acids (IAAs), a PPAR-gamma agonist, on ICH rats and its potential mechanism.	iso-alpha-acids	39-54	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	65-75
19634869-6	2009	Moreover, other constituents, namely, iso-alpha-acids, in combination with the beta-acid hulupone, showed a moderate but selective inhibitory activity only on MCP-1 release.	iso-alpha-acids	38-53	C-C motif chemokine ligand 2	Homo sapiens	159-164
33544749-0	2021	Dietary iso-alpha-acids prevent acetaldehyde-induced liver injury through Nrf2-mediated gene expression.	iso-alpha-acids	8-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	74-78
33544749-7	2021	The acetaldehyde-induced increases in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were suppressed by iso-alpha-acids intake.	iso-alpha-acids	138-153	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	44-70
33544749-7	2021	The acetaldehyde-induced increases in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were suppressed by iso-alpha-acids intake.	iso-alpha-acids	138-153	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	72-75
33544749-7	2021	The acetaldehyde-induced increases in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were suppressed by iso-alpha-acids intake.	iso-alpha-acids	138-153	glutamic pyruvic transaminase, soluble	Mus musculus	81-105
33544749-7	2021	The acetaldehyde-induced increases in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were suppressed by iso-alpha-acids intake.	iso-alpha-acids	138-153	glutamic pyruvic transaminase, soluble	Mus musculus	107-110
33544749-9	2021	In vitro, iso-alpha-acids upregulated the enzymatic activities of GST and ALDH and induced the nuclear translocation of nuclear factor-erythroid-2-related factor 2 (Nfe2l2; Nrf2), a master regulator of antioxidant and detoxifying systems.	iso-alpha-acids	10-25	hematopoietic prostaglandin D synthase	Mus musculus	66-69
33544749-9	2021	In vitro, iso-alpha-acids upregulated the enzymatic activities of GST and ALDH and induced the nuclear translocation of nuclear factor-erythroid-2-related factor 2 (Nfe2l2; Nrf2), a master regulator of antioxidant and detoxifying systems.	iso-alpha-acids	10-25	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	74-78
33544749-9	2021	In vitro, iso-alpha-acids upregulated the enzymatic activities of GST and ALDH and induced the nuclear translocation of nuclear factor-erythroid-2-related factor 2 (Nfe2l2; Nrf2), a master regulator of antioxidant and detoxifying systems.	iso-alpha-acids	10-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	120-163
33544749-9	2021	In vitro, iso-alpha-acids upregulated the enzymatic activities of GST and ALDH and induced the nuclear translocation of nuclear factor-erythroid-2-related factor 2 (Nfe2l2; Nrf2), a master regulator of antioxidant and detoxifying systems.	iso-alpha-acids	10-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	165-171
33544749-9	2021	In vitro, iso-alpha-acids upregulated the enzymatic activities of GST and ALDH and induced the nuclear translocation of nuclear factor-erythroid-2-related factor 2 (Nfe2l2; Nrf2), a master regulator of antioxidant and detoxifying systems.	iso-alpha-acids	10-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	173-177
31001094-2	2019	We previously demonstrated that single or short-term administration of iso-alpha-acids, hop-derived bitter acids in beer, improves the spatial memory of scopolamine-induced amnesia model mice in the Y-maze and enhances novel object recognition in normal mice via activation of the vagus nerve and hippocampal dopaminergic system.	iso-alpha-acids	71-86	HOP homeobox	Mus musculus	88-91
30458988-0	2018	Short-term administration of iso-alpha-acids increases transthyretin transcription in the hippocampus.	iso-alpha-acids	29-44	transthyretin	Mus musculus	55-68
30804789-6	2019	In 6-month-old 5 x FAD mice exhibiting hippocampus inflammation and memory impairment, oral administration of iso-alpha-acids for 7 days reduced inflammatory cytokines, including MIP-1alpha and soluble Abeta and improved object memory in the novel object recognition test.	iso-alpha-acids	110-125	chemokine (C-C motif) ligand 3	Mus musculus	179-189
30804789-8	2019	Manganese-enhanced magnetic resonance imaging (MEMRI) of hippocampi of J20 mice showed increased manganese compared with wild type mice, but iso-alpha-acids canceled this increased MEMRI signal in J20 mice, particularly in the hippocampus CA1 and CA3 region.	iso-alpha-acids	141-156	carbonic anhydrase 1	Mus musculus	239-242
30778295-2	2019	We have previously demonstrated that the consumption of iso-alpha-acids (IAA), which are hop-derived bitter compounds in beer, prevents the formation of disease pathology in a transgenic mouse model of Alzheimer"s disease (AD).	iso-alpha-acids	56-71	HOP homeobox	Mus musculus	89-92
30501069-7	2018	Furthermore, the expression of CD86- and MIP-1alpha-producing cells was reduced in rTg4510 mice administered with iso-alpha-acids.	iso-alpha-acids	114-129	CD86 antigen	Mus musculus	31-35
30501069-7	2018	Furthermore, the expression of CD86- and MIP-1alpha-producing cells was reduced in rTg4510 mice administered with iso-alpha-acids.	iso-alpha-acids	114-129	chemokine (C-C motif) ligand 3	Mus musculus	41-51
21894329-0	2011	Bioavailability of hop-derived iso-alpha-acids and reduced derivatives.	iso-alpha-acids	31-46	homeodomain-only protein	Oryctolagus cuniculus	19-22
29555941-2	2018	Iso-alpha-acids, hop-derived bitter components of beer, have been reported to have various physiological functions via activation of peroxisome proliferator-activated receptor gamma.	iso-alpha-acids	0-15	HOP homeobox	Mus musculus	17-20
29555941-2	2018	Iso-alpha-acids, hop-derived bitter components of beer, have been reported to have various physiological functions via activation of peroxisome proliferator-activated receptor gamma.	iso-alpha-acids	0-15	peroxisome proliferator activated receptor gamma	Mus musculus	133-181
29555941-5	2018	HFD feeding enhances the production of inflammatory cytokines and chemokines, such as TNF-alpha, which was significantly suppressed by iso-alpha-acids administration.	iso-alpha-acids	135-150	tumor necrosis factor	Mus musculus	86-95
28087694-2	2017	Here we found that iso-alpha-acids, hop-derived bitter compounds in beer, enhance microglial phagocytosis and suppress inflammation via activation of the peroxisome proliferator-activated receptor gamma.	iso-alpha-acids	19-34	peroxisome proliferator activated receptor gamma	Mus musculus	154-202
28087694-3	2017	In normal mice, oral administration of iso-alpha-acids led to a significant increase both in CD11b and CD206 double-positive anti-inflammatory type microglia (p < 0.05) and in microglial phagocytosis in the brain.	iso-alpha-acids	39-54	integrin alpha M	Mus musculus	93-98
28087694-3	2017	In normal mice, oral administration of iso-alpha-acids led to a significant increase both in CD11b and CD206 double-positive anti-inflammatory type microglia (p < 0.05) and in microglial phagocytosis in the brain.	iso-alpha-acids	39-54	mannose receptor, C type 1	Mus musculus	103-108
28087694-4	2017	In Alzheimer"s model 5xFAD mice, oral administration of iso-alpha-acids resulted in a 21% reduction in amyloid beta in the cerebral cortex as observed by immunohistochemical analysis, a significant reduction in inflammatory cytokines such as IL-1beta and chemokines including macrophage inflammatory protein-1alpha in the cerebral cortex (p < 0.05) and a significant improvement in a novel object recognition test (p < 0.05), as compared with control-fed 5xFAD mice.	iso-alpha-acids	56-71	interleukin 1 alpha	Mus musculus	242-250
28087694-4	2017	In Alzheimer"s model 5xFAD mice, oral administration of iso-alpha-acids resulted in a 21% reduction in amyloid beta in the cerebral cortex as observed by immunohistochemical analysis, a significant reduction in inflammatory cytokines such as IL-1beta and chemokines including macrophage inflammatory protein-1alpha in the cerebral cortex (p < 0.05) and a significant improvement in a novel object recognition test (p < 0.05), as compared with control-fed 5xFAD mice.	iso-alpha-acids	56-71	chemokine (C-C motif) ligand 3	Mus musculus	276-314