PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27253997-6	2016	The overexpression of Bmal1 relieved the alteration induced by IL-1beta, which was consistent with the effect of the inhibition of Rev-Erbalpha (known as NR1D1, nuclear receptor subfamily 1, group D).	rev-erbalpha	131-143	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	22-27
27686098-0	2016	REV-ERBalpha influences the stability and nuclear localization of the glucocorticoid receptor.	rev-erbalpha	0-12	nuclear receptor subfamily 3 group C member 1	Homo sapiens	70-93
27686098-4	2016	We found that REV-ERBalpha binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha and HSP90beta, a chaperone responsible for the activation of proteins to ensure survival of a cell.	rev-erbalpha	14-26	heat shock protein 90 alpha family class A member 1	Homo sapiens	95-105
27686098-4	2016	We found that REV-ERBalpha binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha and HSP90beta, a chaperone responsible for the activation of proteins to ensure survival of a cell.	rev-erbalpha	14-26	heat shock protein 90 alpha family class B member 1	Homo sapiens	110-119
27686098-5	2016	The presence of REV-ERBalpha influences the stability and nuclear localization of GR by an unknown mechanism, thereby affecting expression of GR target genes, such as IkappaBalpha (Nfkbia) and alcohol dehydrogenase 1 (Adh1).	rev-erbalpha	16-28	nuclear receptor subfamily 3 group C member 1	Homo sapiens	82-84
27686098-5	2016	The presence of REV-ERBalpha influences the stability and nuclear localization of GR by an unknown mechanism, thereby affecting expression of GR target genes, such as IkappaBalpha (Nfkbia) and alcohol dehydrogenase 1 (Adh1).	rev-erbalpha	16-28	NFKB inhibitor alpha	Homo sapiens	167-179
27686098-5	2016	The presence of REV-ERBalpha influences the stability and nuclear localization of GR by an unknown mechanism, thereby affecting expression of GR target genes, such as IkappaBalpha (Nfkbia) and alcohol dehydrogenase 1 (Adh1).	rev-erbalpha	16-28	NFKB inhibitor alpha	Homo sapiens	181-187
27686098-5	2016	The presence of REV-ERBalpha influences the stability and nuclear localization of GR by an unknown mechanism, thereby affecting expression of GR target genes, such as IkappaBalpha (Nfkbia) and alcohol dehydrogenase 1 (Adh1).	rev-erbalpha	16-28	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	193-216
27686098-5	2016	The presence of REV-ERBalpha influences the stability and nuclear localization of GR by an unknown mechanism, thereby affecting expression of GR target genes, such as IkappaBalpha (Nfkbia) and alcohol dehydrogenase 1 (Adh1).	rev-erbalpha	16-28	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	218-222
27875243-4	2017	At the molecular level, REV-ERBalpha modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6).	rev-erbalpha	24-36	fibroblast growth factor 21	Homo sapiens	65-70
27875243-4	2017	At the molecular level, REV-ERBalpha modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6).	rev-erbalpha	24-36	one cut homeobox 1	Homo sapiens	94-118
27875243-4	2017	At the molecular level, REV-ERBalpha modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6).	rev-erbalpha	24-36	one cut homeobox 1	Homo sapiens	120-124
27253997-6	2016	The overexpression of Bmal1 relieved the alteration induced by IL-1beta, which was consistent with the effect of the inhibition of Rev-Erbalpha (known as NR1D1, nuclear receptor subfamily 1, group D).	rev-erbalpha	131-143	nuclear receptor subfamily 1 group D member 1	Homo sapiens	154-159
26125130-11	2015	Consistent with the antiphasic phase relationship between Chkalpha and Rev-erbalpha expression, in cotransfection experiments using HepG2 cells we show that RORalpha4-dependent transactivation of this element is repressed by REV-ERBalpha  Correspondingly, Rev-erbalpha(-/-)mice displayed higher Chkalpha mRNA levels in liver at ZT 12.	rev-erbalpha	71-83	choline kinase alpha	Homo sapiens	58-66
27238018-3	2016	Here, we show that REV-ERBalpha, a core inhibitory component of clock transcription, is targeted for ubiquitination and subsequent degradation by the F-box protein FBXW7.	rev-erbalpha	19-31	F-box and WD repeat domain containing 7	Homo sapiens	164-169
27238018-5	2016	Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of REV-ERBalpha is necessary for FBXW7 recognition.	rev-erbalpha	61-73	cyclin dependent kinase 1	Homo sapiens	0-25
27238018-5	2016	Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of REV-ERBalpha is necessary for FBXW7 recognition.	rev-erbalpha	61-73	cyclin dependent kinase 1	Homo sapiens	27-31
27238018-5	2016	Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of REV-ERBalpha is necessary for FBXW7 recognition.	rev-erbalpha	61-73	F-box and WD repeat domain containing 7	Homo sapiens	91-96
26387865-3	2015	We report here that deregulated expression of MYC or N-MYC disrupts the molecular clock in vitro by directly inducing REV-ERBalpha to dampen expression and oscillation of BMAL1, and this could be rescued by knockdown of REV-ERB.	rev-erbalpha	118-130	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	46-49
26387865-3	2015	We report here that deregulated expression of MYC or N-MYC disrupts the molecular clock in vitro by directly inducing REV-ERBalpha to dampen expression and oscillation of BMAL1, and this could be rescued by knockdown of REV-ERB.	rev-erbalpha	118-130	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	53-58
26387865-3	2015	We report here that deregulated expression of MYC or N-MYC disrupts the molecular clock in vitro by directly inducing REV-ERBalpha to dampen expression and oscillation of BMAL1, and this could be rescued by knockdown of REV-ERB.	rev-erbalpha	118-130	clock circadian regulator	Homo sapiens	82-87
26387865-3	2015	We report here that deregulated expression of MYC or N-MYC disrupts the molecular clock in vitro by directly inducing REV-ERBalpha to dampen expression and oscillation of BMAL1, and this could be rescued by knockdown of REV-ERB.	rev-erbalpha	118-130	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	171-176
25007867-0	2014	REV-ERBalpha inhibits the PTGS2 expression in bovine uterus endometrium stromal and epithelial cells exposed to ovarian steroids.	rev-erbalpha	0-12	prostaglandin-endoperoxide synthase 2	Bos taurus	26-31
24497272-5	2014	Surprisingly, increased protein expression was accompanied with increased cytoplasmic accumulation of Rev-erbalpha, which demonstrated distributions similar to myosin, the major cellular motor protein.	rev-erbalpha	102-114	myosin heavy chain 14	Homo sapiens	160-166
25007867-9	2014	The transcript level of PTGS2 was increased by treatment with the antagonist of REV-ERBalpha in both cell types, but the agonist was ineffective.	rev-erbalpha	80-92	prostaglandin-endoperoxide synthase 2	Bos taurus	24-29
26125130-11	2015	Consistent with the antiphasic phase relationship between Chkalpha and Rev-erbalpha expression, in cotransfection experiments using HepG2 cells we show that RORalpha4-dependent transactivation of this element is repressed by REV-ERBalpha  Correspondingly, Rev-erbalpha(-/-)mice displayed higher Chkalpha mRNA levels in liver at ZT 12.	rev-erbalpha	225-237	choline kinase alpha	Mus musculus	295-303
35267019-11	2022	Mechanistically, mass spectrometry and co-immunoprecipitation analyses revealed that Rev-erbalpha potentiated platelet activation via oligophrenin-1-mediated RhoA/ERM (ezrin/radixin/moesin) pathway.	rev-erbalpha	85-97	oligophrenin 1	Mus musculus	134-148
23201262-2	2013	However, we recently reported that Rev-erbalpha activates connexin43 transcription by forming a complex with Sp1.	rev-erbalpha	35-47	gap junction protein alpha 1	Homo sapiens	58-68
23201262-3	2013	Here we show that heme, a REV-ERB ligand, is dispensable for this novel mechanism and that Rev-erbbeta, having homologies with Rev-erbalpha, does not activate connexin43, but competes with the Rev-erbalpha/Sp1.	rev-erbalpha	127-139	nuclear receptor subfamily 1 group D member 2	Homo sapiens	91-102
23201262-4	2013	The A/B region of Rev-erbalpha, which is not conserved in Rev-erbbeta, is a crucial activating domain, while the ligand binding domain, conserved in Rev-erbbeta, functions as a competitor.	rev-erbalpha	18-30	nuclear receptor subfamily 1 group D member 2	Homo sapiens	149-160
22693436-4	2012	Another component of the latter network, REV-ERBalpha, inhibits the synthesis of the Cdk inhibitor p21.	rev-erbalpha	41-53	cyclin dependent kinase inhibitor 1A	Homo sapiens	99-102
22390238-7	2012	Different patterns of expression between the AM and PM periods were observed, in particular REV-ERBalpha, which was reduced (p < .05) at the PM period in SAT and VAT of both women and men (women: ~53% lower; men: ~78% lower), whereas CLOCK expression was not altered.	rev-erbalpha	92-104	clock circadian regulator	Homo sapiens	237-242
20581824-0	2010	Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.	rev-erbalpha	13-25	nuclear receptor corepressor 1	Homo sapiens	35-40
20581824-0	2010	Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.	rev-erbalpha	13-25	nuclear receptor corepressor 1	Homo sapiens	71-100
18511497-8	2008	These data identify Rev-erbalpha as a new LXR target gene, inhibiting LXR-induction of TLR-4 in a negative transcriptional feedback loop, but not cholesterol homeostasis gene expression.	rev-erbalpha	20-32	toll like receptor 4	Homo sapiens	87-92
25007867-11	2014	Collectively, these results indicate that REV-ERBalpha plays an inhibitory role in the expression of PTGS2 in both bovine USCs and UECs treated with ovarian steroids.	rev-erbalpha	42-54	prostaglandin-endoperoxide synthase 2	Bos taurus	101-106
35428762-5	2022	Notably, pharmacological activation of REV-ERBalpha was shown to phenocopy effects of diabetogenic stressors on the beta-cell through inhibition of autophagic flux, survival, and insulin secretion.	rev-erbalpha	39-51	insulin	Homo sapiens	179-186
35267019-11	2022	Mechanistically, mass spectrometry and co-immunoprecipitation analyses revealed that Rev-erbalpha potentiated platelet activation via oligophrenin-1-mediated RhoA/ERM (ezrin/radixin/moesin) pathway.	rev-erbalpha	85-97	ras homolog family member A	Mus musculus	158-162
32306421-0	2020	REV-ERBalpha activates the mTOR signalling pathway and promotes myotubes differentiation.	rev-erbalpha	0-12	mechanistic target of rapamycin kinase	Homo sapiens	27-31
33285244-11	2021	REV-ERBalpha activates the mTORC1 pathway, leading to phosphorylation of the clock protein BMAL1.	rev-erbalpha	0-12	CREB regulated transcription coactivator 1	Mus musculus	27-33
32306421-6	2020	REV-ERBalpha was found to activate mTORC1 during the differentiation process even in the absence of the differentiation medium.	rev-erbalpha	0-12	CREB regulated transcription coactivator 1	Mus musculus	35-41
31129418-0	2019	Rev-erbalpha can regulate the NF-kappaB/NALP3 pathway to modulate lipopolysaccharide-induced acute lung injury and inflammation.	rev-erbalpha	0-12	NLR family pyrin domain containing 3	Homo sapiens	40-45
31506042-6	2019	Here we show that the reverse unidirectional coupling via phosphorylation of REV-ERBalpha or via mitotic inhibition of transcription, both controlled by CDK1, can elicit entrainment of the circadian clock by the cell cycle.	rev-erbalpha	77-89	cyclin dependent kinase 1	Homo sapiens	153-157
31455731-3	2019	Here, we identify REV-ERBalpha (encoded by Nr1d1), a member of the nuclear hormone receptor family, as a transcriptional repressor that antagonizes RORgammat function in Th17 cells.	rev-erbalpha	18-30	nuclear receptor subfamily 1 group D member 1	Homo sapiens	43-48
32292508-11	2020	The core autophagy gene Atg5 was identified as a direct downstream target of REV-ERBalpha and was suppressed by the REV-ERB agonist SR9009 in SCLC.	rev-erbalpha	77-89	autophagy related 5	Homo sapiens	24-28
31411318-0	2019	Activation of Rev-erbalpha attenuates lipopolysaccharide-induced inflammatory reactions in human endometrial stroma cells via suppressing TLR4-regulated NF-kappaB activation.	rev-erbalpha	14-26	toll like receptor 4	Homo sapiens	138-142
31411318-0	2019	Activation of Rev-erbalpha attenuates lipopolysaccharide-induced inflammatory reactions in human endometrial stroma cells via suppressing TLR4-regulated NF-kappaB activation.	rev-erbalpha	14-26	nuclear factor kappa B subunit 1	Homo sapiens	153-162
31129418-5	2019	Herein, we demonstrate that Rev-erbalpha reduces IL-1beta production and lung injury following an intraperitoneal injection of LPS, which is dependent on the NF-kappaB/NALP3 pathway.	rev-erbalpha	28-40	interleukin 1 beta	Homo sapiens	49-57
31129418-5	2019	Herein, we demonstrate that Rev-erbalpha reduces IL-1beta production and lung injury following an intraperitoneal injection of LPS, which is dependent on the NF-kappaB/NALP3 pathway.	rev-erbalpha	28-40	NLR family pyrin domain containing 3	Homo sapiens	168-173
31129418-6	2019	Thus, Rev-erbalpha is able to decrease the extent of acute lung injury by regulating IL-1beta production.	rev-erbalpha	6-18	interleukin 1 beta	Homo sapiens	85-93
30397120-4	2018	We illustrate this finding by showing that REV-ERBalpha controls OGT-dependent activities of the cytoplasmic protein kinase AKT, an essential relay in insulin signaling, and of ten-of-eleven translocation (TET) enzymes in the nucleus.	rev-erbalpha	43-55	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	65-68
30397120-4	2018	We illustrate this finding by showing that REV-ERBalpha controls OGT-dependent activities of the cytoplasmic protein kinase AKT, an essential relay in insulin signaling, and of ten-of-eleven translocation (TET) enzymes in the nucleus.	rev-erbalpha	43-55	AKT serine/threonine kinase 1	Homo sapiens	124-127
28599788-4	2017	Here, we report that nuclear receptor subfamily 1, group D, member 1 (NR1D1; Rev-erbalpha) inhibited DNA repair of ROS-induced DNA damage in breast cancer cells.	rev-erbalpha	77-89	nuclear receptor subfamily 1 group D member 1	Homo sapiens	21-68
28599788-4	2017	Here, we report that nuclear receptor subfamily 1, group D, member 1 (NR1D1; Rev-erbalpha) inhibited DNA repair of ROS-induced DNA damage in breast cancer cells.	rev-erbalpha	77-89	nuclear receptor subfamily 1 group D member 1	Homo sapiens	70-75
28712038-0	2017	Binding mode prediction and MD/MMPBSA-based free energy ranking for agonists of REV-ERBalpha/NCoR.	rev-erbalpha	80-92	nuclear receptor corepressor 1	Homo sapiens	93-97