PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9211907-0	1997	Oxidation process of bovine heart ubiquinol-cytochrome c reductase as studied by stopped-flow rapid-scan spectrophotometry and simulations based on the mechanistic Q cycle model.	ubiquinol	34-43	LOC104968582	Bos taurus	44-56
9201979-3	1997	Pre-steady-state kinetics indicate that these compounds bind to the complex on the intermembrane space side, thereby blocking reduction of cytochrome b via the ubiquinol oxidation site.	ubiquinol	160-169	cytochrome b	Saccharomyces cerevisiae S288C	139-151
9202003-2	1997	The redox reactions of the bis-heme cytochrome b of the ubiquinol:cytochrome c oxidoreductase complex (complex III, bc1 complex) were studied in bovine heart submitochondrial particles (SMP).	ubiquinol	56-65	cytochrome b	Bos taurus	36-48
27396880-0	1997	Superoxide Dismutase Inhibition of Oxidation of Ubiquinol and Concomitant Formation of Hydrogen Peroxide.	ubiquinol	48-57	superoxide dismutase 1	Homo sapiens	0-20
9003361-1	1996	cDNA clones encoding subunit VII of the Neurospora crassa bc1 complex (ubiquinol:cytochrome-c oxidoreductase), which is homologous with subunit VIII of the complex from yeast (encoded by QCR8), were identified on the basis of functional complementation of a yeast QCR8 deletion strain.	ubiquinol	71-80	ubiquinol--cytochrome-c reductase subunit 8	Saccharomyces cerevisiae S288C	187-191
8958158-4	1997	Furthermore, the results reported herein show that, in the presence of nicotinamide adenine dinucleotide (NADH) and DT-diaphorase, ubiquinol-containing multilamellar vesicles exposed to a lipophilic azocompound did not undergo lipid peroxidation, whereas in vesicles lacking either NADH or DT-diaphorase, thiobarbituric acid reactive substances (TBARS) formation occurred.	ubiquinol	131-140	NAD(P)H quinone dehydrogenase 1	Homo sapiens	116-129
8958158-4	1997	Furthermore, the results reported herein show that, in the presence of nicotinamide adenine dinucleotide (NADH) and DT-diaphorase, ubiquinol-containing multilamellar vesicles exposed to a lipophilic azocompound did not undergo lipid peroxidation, whereas in vesicles lacking either NADH or DT-diaphorase, thiobarbituric acid reactive substances (TBARS) formation occurred.	ubiquinol	131-140	NAD(P)H quinone dehydrogenase 1	Homo sapiens	290-303
9266534-2	1997	Both 11778/ND4 and 3460/ND1 mutations induced rotenone resistance and 11778/ND4 showed an increased K(m) for ubiquinol-2 with respect to the control group.	ubiquinol	109-118	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	76-79
9003361-1	1996	cDNA clones encoding subunit VII of the Neurospora crassa bc1 complex (ubiquinol:cytochrome-c oxidoreductase), which is homologous with subunit VIII of the complex from yeast (encoded by QCR8), were identified on the basis of functional complementation of a yeast QCR8 deletion strain.	ubiquinol	71-80	ubiquinol--cytochrome-c reductase subunit 8	Saccharomyces cerevisiae S288C	264-268
8601750-7	1996	Sodium formate, which scavenges .OH to form CO2-., enhanced ubiquinol formation but partially inhibited the degradation of the ubiquinone ring.	ubiquinol	60-69	complement C2	Homo sapiens	44-47
8200339-0	1994	Analysis of cytochrome-b amino acid residues forming the contact face with the iron-sulfur subunit of ubiquinol:cytochrome-c reductase in Saccharomyces cerevisiae.	ubiquinol	102-111	cytochrome b	Saccharomyces cerevisiae S288C	12-24
7673215-0	1995	Role of the evolutionarily conserved cytochrome b tryptophan 142 in the ubiquinol oxidation catalyzed by the bc1 complex in the yeast Saccharomyces cerevisiae.	ubiquinol	72-81	cytochrome b	Saccharomyces cerevisiae S288C	37-49
15299325-0	1995	A new crystal form of bovine heart ubiquinol: cytochrome c oxidoreductase: determination of space group and unit-cell parameters.	ubiquinol	35-44	LOC104968582	Bos taurus	46-58
15299325-1	1995	Ubiquinol:cytochrome c oxidoreductase, the middle segment of the mitochondrial respiratory chain, is a multi-subunit transmembrane redox enzyme.	ubiquinol	0-9	LOC104968582	Bos taurus	10-22
7727497-1	1995	The cytochrome-c reductase (EC 1.10.2.2) of the mitochondrial respiratory chain couples electron transport from ubiquinol to cytochrome c with proton translocation across the inner mitochondrial membrane.	ubiquinol	112-121	cytochrome c	Solanum tuberosum	125-137
8070276-3	1994	In all of these organisms, the cytochrome bc1 complex transfers electrons from ubiquinol to cytochrome c and links this electron transfer to translocation of protons across the membrane in which it resides, thus converting the available free energy of the oxidation-reduction reaction into an electrochemical proton gradient.	ubiquinol	79-88	cytochrome c, somatic	Homo sapiens	92-104
1396680-4	1992	Upon reconstitution into phospholipid membranes, the dimeric enzyme catalyzes electron transfer from a synthetic ubiquinol to equine cytochrome c with a turnover number of 50 s-1.	ubiquinol	113-122	cytochrome c, somatic	Equus caballus	133-145
8241712-3	1993	Therefore, we investigated the effects of ubiquinol on the formation and survival of ferryl species of myoglobin and on metmyoglobin itself.	ubiquinol	42-51	myoglobin	Homo sapiens	103-112
8394320-1	1993	The iron-sulfur protein of the cytochrome bc1 complex oxidizes ubiquinol at center P in the protonmotive Q cycle mechanism, transferring one electron to cytochrome c1 and generating a low-potential ubisemiquinone anion which reduces the low-potential cytochrome b-566 heme group.	ubiquinol	63-72	cytochrome b	Saccharomyces cerevisiae S288C	31-43
8382478-0	1993	Steady-state kinetics of ubiquinol-cytochrome c reductase in bovine heart submitochondrial particles: diffusional effects.	ubiquinol	25-34	LOC104968582	Bos taurus	35-47
8382478-1	1993	In an attempt to establish the relative importance of diffusional and chemical control in the reactivity of the two of the two substrates, ubiquinol and cytochrome c, we have undertaken as extensive characterization of the steady-state kinetics of ubiquinol-cytochrome c reductase (EC 1.10.2.2) when present in open submitochondrial particles from bovine heart.	ubiquinol	139-148	LOC104968582	Bos taurus	258-270
8382478-17	1993	values for both ubiquinol and cytochrome c were linear, but the activation energy was much higher for the former, particularly when calculated for ubiquinol dissolved in the lipid phase; the very low value of activation energy of the kmin.	ubiquinol	147-156	LOC104968582	Bos taurus	30-42
1324169-4	1992	The purified complex is bifunctional, as it has the ability to transfer electrons from ubiquinol to cytochrome c and to cleave off the presequences of mitochondrial precursor proteins.	ubiquinol	87-96	cytochrome c	Solanum tuberosum	100-112
1351746-1	1992	Ubiquinol-1 in aerated aqueous solution inactivates several enzymes--alanine aminotransferase, alkaline phosphatase, Na+/K(+)-ATPase, creatine kinase and glutamine synthetase--but not isocitrate dehydrogenase and malate dehydrogenase.	ubiquinol	0-11	glutamate-ammonia ligase	Homo sapiens	154-174
1351746-1	1992	Ubiquinol-1 in aerated aqueous solution inactivates several enzymes--alanine aminotransferase, alkaline phosphatase, Na+/K(+)-ATPase, creatine kinase and glutamine synthetase--but not isocitrate dehydrogenase and malate dehydrogenase.	ubiquinol	0-11	malic enzyme 1	Homo sapiens	213-233
1932040-3	1991	The inhibitory action of DDT on phosphorylation efficiency may result from: (1) a direct effect on the ubiquinol-cytochrome c segment of the redox chain; (2) direct action on the ATP-synthetase complex; (3) partial inhibition of the phosphate transporter.	ubiquinol	103-112	cytochrome c, somatic	Homo sapiens	113-125
1657909-0	1991	Significance of the "Rieske" iron-sulfur protein for formation and function of the ubiquinol-oxidation pocket of mitochondrial cytochrome c reductase (bc1 complex).	ubiquinol	83-92	cytochrome c, somatic	Homo sapiens	127-139
1657909-1	1991	The binding of specific inhibitors to the ubiquinol oxidation pocket ("QP center") of cytochrome c reductase was analyzed before and after removal of bound phospholipid and the "Rieske" iron-sulfur protein using optical spectroscopy and fluorescence quench binding assays.	ubiquinol	42-51	cytochrome c, somatic	Homo sapiens	86-98
1656052-4	1991	The crystalline protein showed enzymic activity catalyzing electron transfer from ubiquinol-2 to cytochrome c.	ubiquinol	82-91	LOC104968582	Bos taurus	97-109
1654853-0	1991	The kinetic mechanism of ubiquinol: cytochrome c reductase at steady state.	ubiquinol	25-34	cytochrome c, somatic	Homo sapiens	36-48
1654853-1	1991	The steady-state kinetics of ubiquinol: cytochrome c reductase (cytochrome bc1 complex) is analyzed in this work.	ubiquinol	29-38	cytochrome c, somatic	Homo sapiens	40-52
1654853-5	1991	This has been substantiated by presteady-state measurements of the reduction and oxidation of cytochrome b by a short-chain homolog of ubiquinol.	ubiquinol	135-144	mitochondrially encoded cytochrome b	Homo sapiens	94-106
1651245-6	1991	This study provides biochemical and biophysical information for identifying a region in mitochondrial cytochrome b that may fulfill a crucial role in the binding of ubiquinol to the bc1 complex.	ubiquinol	165-174	cytochrome b	Saccharomyces cerevisiae S288C	102-114
2177322-3	1990	This enables the monitoring of the oxidation of ubiquinols by the Rieske protein through the steady-state electron transfer to cytochrome c in solution.	ubiquinol	48-58	cytochrome c, somatic	Homo sapiens	127-139
1851164-9	1991	Nonetheless it catalyzes electron transfer from a short chain ubiquinol analog to equine cytochrome c with a turnover number of 50-170 mol of cytochrome c reduced per mol of cytochrome c1 per s, as compared with approximately 220 in whole mitochondria.	ubiquinol	62-71	cytochrome c, somatic	Equus caballus	89-101
1851164-9	1991	Nonetheless it catalyzes electron transfer from a short chain ubiquinol analog to equine cytochrome c with a turnover number of 50-170 mol of cytochrome c reduced per mol of cytochrome c1 per s, as compared with approximately 220 in whole mitochondria.	ubiquinol	62-71	cytochrome c, somatic	Equus caballus	142-154
1851164-9	1991	Nonetheless it catalyzes electron transfer from a short chain ubiquinol analog to equine cytochrome c with a turnover number of 50-170 mol of cytochrome c reduced per mol of cytochrome c1 per s, as compared with approximately 220 in whole mitochondria.	ubiquinol	62-71	cytochrome c1-1, heme protein, mitochondrial	Solanum tuberosum	174-187
2177322-5	1990	The second electron from ubiquinol is diverted to oxygen by the isolated Rieske protein, and forms oxygen radicals that contribute to the steady-state reduction of cytochrome c.	ubiquinol	25-34	cytochrome c, somatic	Homo sapiens	164-176
2177322-6	1990	Under anaerobic conditions, however, the reduction of cytochrome c catalyzed by the protein becomes mechanicistically identical to the chemical reduction by ubiquinols.	ubiquinol	157-167	cytochrome c, somatic	Homo sapiens	54-66
2078867-4	1990	Their ubiquinol (QH2)-cytochrome c reductase/mole cytochrome b activity decreased by about 50%.	ubiquinol	6-15	cytochrome b	Saccharomyces cerevisiae S288C	50-62
2078867-4	1990	Their ubiquinol (QH2)-cytochrome c reductase/mole cytochrome b activity decreased by about 50%.	ubiquinol	17-20	cytochrome b	Saccharomyces cerevisiae S288C	50-62
2168725-0	1990	Electron microscopic characterization of helical filaments formed by subunits I and II (core proteins) of ubiquinol: cytochrome c reductase from Neurospora mitochondria.	ubiquinol	106-115	cytochrome c, somatic	Homo sapiens	117-129
1849003-10	1991	At all stages during the reaction, cytochrome b-562 is in equilibrium with the redox potential of the ubiquinone-2/ubiquinol-2 couple but not with that of the duroquinone/duroquinol couple.	ubiquinol	115-124	cytochrome b	Bos taurus	35-47
2154475-7	1990	We report here nine novel cytochrome b structures conferring a variety of respiratory sufficient phenotypes, obtained from five respiratory deficient mutations affecting a short region of the protein (positions 131-138 of the polypeptide chain), presumably belonging to the ubiquinol oxidizing center of the bc1 complex.	ubiquinol	274-283	cytochrome b	Saccharomyces cerevisiae S288C	26-38
34113829-2	2021	Interestingly, DHODH is located in the inner mitochondrial membrane and contributes to provide ubiquinol to the respiratory chain.	ubiquinol	95-104	dihydroorotate dehydrogenase	Mus musculus	15-20
32797125-8	2020	After ubiquinol supplementation, PTH, OC, OPG, alkaline phosphatase, leptin, insulin, noradrenaline and PGC-1alpha levels increased in the supplemented group compared to the control group after the exercise protocol.	ubiquinol	6-15	parathyroid hormone	Homo sapiens	33-36
34844107-10	2022	Regarding the metabolic profile of gut microbiota, predicted metabolic pathways related to propionate degradation and ubiquinol biosynthesis predominated in the MET group.	ubiquinol	118-127	SAFB like transcription modulator	Homo sapiens	161-164
34741366-1	2022	The importance of the alternative donation of electrons to the ubiquinol pool via the electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase (ETF/ETFQO) complex has been demonstrated.	ubiquinol	63-72	electron-transfer flavoprotein:ubiquinone oxidoreductase	Arabidopsis thaliana	179-184
2354808-8	1990	The results of a broad investigation on ubiquinol cytochrome c reductase in bovine heart submitochondrial particles indicated that the enzymic rate is not diffusion-controlled by ubiquinol, whereas the interaction of cytochrome c with the enzyme is clearly diffusion-limited.	ubiquinol	40-49	LOC104968582	Bos taurus	50-62
2354808-8	1990	The results of a broad investigation on ubiquinol cytochrome c reductase in bovine heart submitochondrial particles indicated that the enzymic rate is not diffusion-controlled by ubiquinol, whereas the interaction of cytochrome c with the enzyme is clearly diffusion-limited.	ubiquinol	40-49	LOC104968582	Bos taurus	217-229
34490974-4	2022	Fenpicoxamid inhibits complex III of the respiratory chain at the ubiquinone reduction site (Qi site) of the mitochondrially encoded cytochrome b, a different site than the widely-used strobilurins which inhibit the same complex at the ubiquinol oxidation site (Qo site).	ubiquinol	236-245	cytb	Zymoseptoria tritici	133-145
34252606-2	2021	The assembly of 10 subunits encoded by nuclear DNA and one by mitochondrial DNA result in the functional CIII which transfers electrons from ubiquinol to cytochrome c.	ubiquinol	141-150	cytochrome c, somatic	Homo sapiens	154-166
34289436-3	2021	SDHB couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.	ubiquinol	101-110	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-4
3015618-1	1986	Dimeric ubiquinol:cytochrome c reductase of Neurospora mitochondria was isolated as a protein-Triton complex and free of ubiquinol (Q).	ubiquinol	8-17	cytochrome c, somatic	Homo sapiens	18-30
2543573-1	1989	The molecular determinants of the dichroic properties of the b cytochromes in various ubiquinol:cytochrome c reductases.	ubiquinol	86-95	cytochrome c	Gossypium hirsutum	96-108
2543567-1	1989	Inactivation of the gene encoding the 11-kDa subunit VIII of yeast ubiquinol:cytochrome c oxidoreductase leads to an inactive complex, which lacks detectable cytochrome b [Maarse, A. C., De Haan, M., Schoppink, P. J., Berden, J.	ubiquinol	67-76	cytochrome b	Saccharomyces cerevisiae S288C	158-170
24424680-0	1989	How rapid are the internal reactions of the ubiquinol:cytochrome c 2 oxidoreductase?	ubiquinol	44-53	complement C2	Homo sapiens	65-68
2829962-2	1988	The method has been applied to mitochondrial ubiquinol cytochrome c reductase, using short-chain ubiquinols as reductants at saturating cytochrome c.	ubiquinol	97-107	cytochrome c, somatic	Homo sapiens	55-67
2829962-2	1988	The method has been applied to mitochondrial ubiquinol cytochrome c reductase, using short-chain ubiquinols as reductants at saturating cytochrome c.	ubiquinol	97-107	cytochrome c, somatic	Homo sapiens	136-148
3015618-0	1986	Dimeric ubiquinol:cytochrome c reductase of Neurospora mitochondria contains one cooperative ubiquinone-reduction centre.	ubiquinol	8-17	cytochrome c, somatic	Homo sapiens	18-30
2845965-1	1988	The steady-state kinetics of ubiquinol cytochrome c reductase was investigated in submitochondrial particles using ubiquinol-1 as electron donor in media of increasing viscosities obtained by water-polyethylene glycol mixtures.	ubiquinol	29-38	LOC104968582	Bos taurus	39-51
2845965-1	1988	The steady-state kinetics of ubiquinol cytochrome c reductase was investigated in submitochondrial particles using ubiquinol-1 as electron donor in media of increasing viscosities obtained by water-polyethylene glycol mixtures.	ubiquinol	115-126	LOC104968582	Bos taurus	39-51
3023079-2	1986	We have investigated the oxidation of the reduced ubiquinol:cytochrome c reductase (bc1 complex) isolated from beef heart mitochondria.	ubiquinol	50-59	cytochrome c, somatic	Homo sapiens	60-72
3015618-1	1986	Dimeric ubiquinol:cytochrome c reductase of Neurospora mitochondria was isolated as a protein-Triton complex and free of ubiquinol (Q).	ubiquinol	121-130	cytochrome c, somatic	Homo sapiens	18-30
3024904-4	1986	The steady-state ubiquinol-cytochrome c reductase analysis of the active enzymes indicates that all the bc1 complexes follow essentially a ping-pong mechanism, with the cytochrome c substrate displaying a partial competitive inhibition vs the ubiquinol substrate.	ubiquinol	17-26	cytochrome c, somatic	Gallus gallus	27-39
3009448-11	1986	One pathway allows the initial phase of cytochrome b reduction by a myxothiazol-sensitive reaction in which reduction of b by ubisemiquinone is linked to reduction of iron-sulfur protein and cytochrome c1 by ubiquinol.	ubiquinol	208-217	mitochondrially encoded cytochrome b	Homo sapiens	40-52
2999105-8	1985	The isolated iron-sulfur protein catalyzes reduction of cytochrome c by ubiquinol, which is insensitive to antimycin, at a rate of 0.03 mumol of cytochrome c reduced/min/nmol of protein, while the purified cytochrome c1 has no such catalytic activity.	ubiquinol	72-81	cytochrome c, somatic	Homo sapiens	56-68
2999105-8	1985	The isolated iron-sulfur protein catalyzes reduction of cytochrome c by ubiquinol, which is insensitive to antimycin, at a rate of 0.03 mumol of cytochrome c reduced/min/nmol of protein, while the purified cytochrome c1 has no such catalytic activity.	ubiquinol	72-81	cytochrome c, somatic	Homo sapiens	145-157
6320810-3	1984	The steady-state level of reduction of cytochrome c by ubiquinol-2 varies with the molar ratios of the complexes and with the presence of antimycin in a way that can be quantitatively accounted for by a model in which cytochrome c acts as a freely diffusible pool on the membrane.	ubiquinol	55-64	cytochrome c, somatic	Homo sapiens	39-51
6321316-7	1983	The molar catalytic activity of ubiquinol-9-cytochrome c reductase at 25 degrees C amounts to 50s-1 for the N. crassa complex III and 70-100s-1 for the bovine complexes.	ubiquinol	32-41	LOC104968582	Bos taurus	44-56
6321316-8	1983	After reincorporation into phospholipid vesicles, all preparations how tight coupling between electron transfer from ubiquinol to cytochrome c and proton translocation across the phospholipid bilayer.	ubiquinol	117-126	LOC104968582	Bos taurus	130-142
6315061-2	1983	At concentrations below 1000 mol per mol of cytochrome c1, DCCD is able to block the proton-translocating activity associated to succinate or ubiquinol oxidation without inhibiting the steady-state redox activity of the b-c1 complex either in intact mitochondrial particles or in the isolated ubiquinol-cytochrome c reductase reconstituted in phospholipid vesicles.	ubiquinol	142-151	cytochrome c1	Homo sapiens	44-57
6313049-6	1983	The cytochrome b of the ubiquinol:cytochrome c oxidoreductase can be reduced by electrons from the reaction centres through two pathways: one is sensitive to antimycin and the other to myxothiazol.	ubiquinol	24-33	cytochrome b	Equus caballus	4-16
6313049-6	1983	The cytochrome b of the ubiquinol:cytochrome c oxidoreductase can be reduced by electrons from the reaction centres through two pathways: one is sensitive to antimycin and the other to myxothiazol.	ubiquinol	24-33	cytochrome c, somatic	Equus caballus	34-46
21494412-2	1983	(2) In the presence of antimycin, flash-induced reduction of cytochrome b-561 is dependent on a coupled oxidation of ubiquinol.	ubiquinol	117-126	cytochrome b561	Homo sapiens	61-77
21494412-6	1983	Over a limited range of concentration (0-3 mol ubiquinol/mol cytochrome b-561), the kinetics showed a second-order process, first order with respect to ubiquinol from the pool.	ubiquinol	47-56	cytochrome b561	Homo sapiens	61-77
21494412-6	1983	Over a limited range of concentration (0-3 mol ubiquinol/mol cytochrome b-561), the kinetics showed a second-order process, first order with respect to ubiquinol from the pool.	ubiquinol	152-161	cytochrome b561	Homo sapiens	61-77
21494412-20	1983	The results are interpreted as showing that at potentials higher than 180 mV, ubiquinol stoichiometric with cytochrome b-561 reaches the complex from the reaction center.	ubiquinol	78-87	cytochrome b561	Homo sapiens	108-124
6320810-3	1984	The steady-state level of reduction of cytochrome c by ubiquinol-2 varies with the molar ratios of the complexes and with the presence of antimycin in a way that can be quantitatively accounted for by a model in which cytochrome c acts as a freely diffusible pool on the membrane.	ubiquinol	55-64	cytochrome c, somatic	Homo sapiens	218-230
6293557-1	1982	A kinetic study on ubiquinol-cytochrome c reductase (EC 1.10.2.2) has been undertaken either in situ in KCN-inhibited mitochondria and submitochondrial particles, or in the isolated cytochrome b-c1 complex using ubiquinol-1 and exogenous cytochrome c as substrates.	ubiquinol	19-28	LOC104968582	Bos taurus	29-41
6293557-1	1982	A kinetic study on ubiquinol-cytochrome c reductase (EC 1.10.2.2) has been undertaken either in situ in KCN-inhibited mitochondria and submitochondrial particles, or in the isolated cytochrome b-c1 complex using ubiquinol-1 and exogenous cytochrome c as substrates.	ubiquinol	19-28	LOC104968582	Bos taurus	238-250
6288087-0	1982	The site of inhibition by 5,5"-dithiobis(2-nitrobenzoate) in ubiquinol: cytochrome c oxidoreductase.	ubiquinol	61-70	cytochrome c, somatic	Homo sapiens	72-84
33981038-6	2021	Mechanistically, DHODH operates in parallel to mitochondrial GPX4 (but independently of cytosolic GPX4 or FSP1) to inhibit ferroptosis in the mitochondrial inner membrane by reducing ubiquinone to ubiquinol (a radical-trapping antioxidant with anti-ferroptosis activity).	ubiquinol	197-206	dihydroorotate dehydrogenase (quinone)	Homo sapiens	17-22
7319059-0	1981	Complete inhibition of electron transfer from ubiquinol to cytochrome b by the combined action of antimycin and myxothiazol.	ubiquinol	46-55	mitochondrially encoded cytochrome b	Homo sapiens	59-71
6277826-5	1981	The apparent Km for ubiquinol-1 is increased and the maximal velocity of ubiquinol-cytochrome c reductase is decreased by DCCD.	ubiquinol	20-29	cytochrome c, somatic	Homo sapiens	83-95
6277826-7	1981	The results therefore suggest the presence of a DCCD-sensitive electron transfer step in the redox pathways from ubiquinol to cytochrome c.	ubiquinol	113-122	cytochrome c, somatic	Homo sapiens	126-138
224062-24	1979	15, 338-344) and thus demonstrate that this iron-sulfur protein is required for electron transfer from ubiquinol to cytochrome c in the mitochondrial respiratory chain.	ubiquinol	103-112	LOC104968582	Bos taurus	116-128
237540-14	1975	It is concluded that electron flow along complex III, from ubiquinol to cytochrome c, is directly coupled to vectorial proton translocation.	ubiquinol	59-68	cytochrome c, somatic	Homo sapiens	72-84
237540-15	1975	The present data suggest that there exist(s) between ubiquinol and cytochrome c one (or two) respiratory carrier(s), whose oxido-reduction is directly linked to effective transmembrane proton translocation.	ubiquinol	53-62	cytochrome c, somatic	Homo sapiens	67-79
6293557-3	1982	At low concentrations of cytochrome c, however, the titrations as a function of quinol concentration appear biphasic both in mitochondria and in submitochondrial particles containing trapped cytochrome c inside the vesicle space, fitting two apparent Km values for ubiquinol-1.	ubiquinol	265-274	LOC104968582	Bos taurus	25-37
6293557-4	1982	Relatively high antimycin-sensitive rates of ubiquinol-1-cytochrome c reductase have been found in submitochondrial particles: both the Vmax and the Km for ubiquinol-1 are, however, affected by the overall orientation of the particle preparation, i.e., by the reactivity of cytochrome c with its proper site.	ubiquinol	45-54	LOC104968582	Bos taurus	57-69
6293557-4	1982	Relatively high antimycin-sensitive rates of ubiquinol-1-cytochrome c reductase have been found in submitochondrial particles: both the Vmax and the Km for ubiquinol-1 are, however, affected by the overall orientation of the particle preparation, i.e., by the reactivity of cytochrome c with its proper site.	ubiquinol	45-54	LOC104968582	Bos taurus	274-286
7430148-8	1980	To accommodate the available evidence on Site 2 substrates, it is concluded that the substrate hydrogens are first transferred to ubiquinone, 2 H+ per 2e then appear in the medium by protolytic dehydrogenation of a species of ubiquinol or ubiquinol-protein having the appropriate sidedness (designated Site 2A), and the other 2 H+ are translocated from the matrix to the medium on passage of 2e- through the cytochrome b x c1 complex (designated Site 2B).	ubiquinol	226-235	cytochrome b, mitochondrial	Rattus norvegicus	408-420
7430148-8	1980	To accommodate the available evidence on Site 2 substrates, it is concluded that the substrate hydrogens are first transferred to ubiquinone, 2 H+ per 2e then appear in the medium by protolytic dehydrogenation of a species of ubiquinol or ubiquinol-protein having the appropriate sidedness (designated Site 2A), and the other 2 H+ are translocated from the matrix to the medium on passage of 2e- through the cytochrome b x c1 complex (designated Site 2B).	ubiquinol	239-248	cytochrome b, mitochondrial	Rattus norvegicus	408-420
6244177-0	1980	A model for the cytochrome b dimer of the ubiquinol: cytochrome c oxidoreductase as a proton translocator.	ubiquinol	42-51	mitochondrially encoded cytochrome b	Homo sapiens	16-28
6244177-0	1980	A model for the cytochrome b dimer of the ubiquinol: cytochrome c oxidoreductase as a proton translocator.	ubiquinol	42-51	cytochrome c, somatic	Homo sapiens	53-65
6244177-0	1980	A model for the cytochrome b dimer of the ubiquinol: cytochrome c oxidoreductase as a proton translocator.	ubiquinol	42-51	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	66-80
170082-24	1975	The second form of cytochrome b is characterized by its sluggish reduction by QH2 or durohydroquinone.	ubiquinol	78-81	cytochrome b, mitochondrial	Rattus norvegicus	19-31
32003645-6	2021	Results: Ubiquinol-10 elevated plasma CoQ10 concentration to 5.62 mug/mL and significantly decreased activities of the serum extravasate enzymes, CK, ALT, LDH (P < 0.01), and AST (P < 0.05) on day 6.	ubiquinol	9-18	solute carrier family 17 member 5	Homo sapiens	178-181
32686200-3	2020	The succinate dehydrogenase enzyme complex (SDH) couples the oxidation of succinate to fumarate in the citric acid cycle and the reduction of ubiquinone to ubiquinol in the electron transport chain.	ubiquinol	156-165	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	4-27
33482334-9	2021	Ubiquinol was also more efficient compared to ubiquinone in reverting the expression of the senescent phenotype, quantified in terms of beta-galactosidase positivity, p21, collagen type 1, and elastin at the gene and protein expression levels.	ubiquinol	0-9	H3 histone pseudogene 16	Homo sapiens	167-170
33482334-9	2021	Ubiquinol was also more efficient compared to ubiquinone in reverting the expression of the senescent phenotype, quantified in terms of beta-galactosidase positivity, p21, collagen type 1, and elastin at the gene and protein expression levels.	ubiquinol	0-9	elastin	Homo sapiens	193-200
33289903-1	2021	The alternative oxidase (AOX) is a monotopic diiron carboxylate protein that catalyses the oxidation of ubiquinol and the reduction of oxygen to water.	ubiquinol	104-113	acyl-CoA oxidase 1	Homo sapiens	4-23
33289903-1	2021	The alternative oxidase (AOX) is a monotopic diiron carboxylate protein that catalyses the oxidation of ubiquinol and the reduction of oxygen to water.	ubiquinol	104-113	acyl-CoA oxidase 1	Homo sapiens	25-28
33338489-1	2021	The bc1 complex is a proton pump of the mitochondrial electron transport chain which transfers electrons from ubiquinol to cytochrome c.	ubiquinol	110-119	cytochrome c, somatic	Homo sapiens	123-135
32686200-3	2020	The succinate dehydrogenase enzyme complex (SDH) couples the oxidation of succinate to fumarate in the citric acid cycle and the reduction of ubiquinone to ubiquinol in the electron transport chain.	ubiquinol	156-165	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	44-47
32565080-0	2020	Kinetic and structural characterisation of the ubiquinol-binding site and oxygen reduction by the trypanosomal alternative oxidase.	ubiquinol	47-56	acyl-CoA oxidase 1	Homo sapiens	111-130
33023026-7	2020	In glaucomatous retina, ubiquinol supplementation significantly promoted RGC survival, blocked BAX activation and increased TFAM and OXPHOS complex II protein expression.	ubiquinol	24-33	BCL2-associated X protein	Mus musculus	95-98
33023026-7	2020	In glaucomatous retina, ubiquinol supplementation significantly promoted RGC survival, blocked BAX activation and increased TFAM and OXPHOS complex II protein expression.	ubiquinol	24-33	transcription factor A, mitochondrial	Mus musculus	124-128
33023026-9	2020	These findings indicate that ubiquinol promotes RGC survival by increasing TFAM expression and OXPHOS complex II activity in glaucomatous neurodegeneration, and that ubiquinol enhances RGC survival and preserves visual function against oxidative stress.	ubiquinol	29-38	transcription factor A, mitochondrial	Mus musculus	75-79
32565080-10	2020	SIGNIFICANCE: The alternative oxidase is a ubiquinol oxidoreductase enzyme that catalyses the oxidation of ubiquinol and the reduction of oxygen to water.	ubiquinol	43-52	acyl-CoA oxidase 1	Homo sapiens	18-37
32041223-6	2020	Red blood cells (RBC), hematocrit, hemoglobin, VEGF, NO, EGF, IL-1ra, and IL-10 increased in the ubiquinol group while IL-1, IL-8, and MCP-1 decreased.	ubiquinol	97-106	interleukin 1 receptor antagonist	Homo sapiens	62-68
31944172-11	2020	This study shows that sustained high autophagic flux by RUBCN deficiency in PTECs leads to metabolic syndrome concomitantly with an accelerated mobilization of phospholipids from cellular membranes to lysosomes.Abbreviations: ABC: ATP binding cassette; ACADM: acyl-CoA dehydrogenase medium chain; ACTB: actin, beta; ATG: autophagy related; AUC: area under the curve; Baf: bafilomycin A1; BAT: brown adipose tissue; BODIPY: boron-dipyrromethene; BSA: bovine serum albumin; BW: body weight; CAT: chloramphenicol acetyltransferase; CM: complete medium; CPT1A: carnitine palmitoyltransferase 1a, liver; CQ: chloroquine; CTRL: control; EGFP: enhanced green fluorescent protein; CTSD: cathepsin D; EAT: epididymal adipose tissue; EGFR: epidermal growth factor receptor; EIF4EBP1: eukaryotic translation initiation factor 4E binding protein 1; FA: fatty acid; FBS: fetal bovine serum; GTT: glucose tolerance test; HE: hematoxylin and eosin; HFD: high-fat diet; I/R: ischemia-reperfusion; ITT: insulin tolerance test; KAP: kidney androgen regulated protein; KO: knockout; LAMP1: lysosomal associated membrane protein 1; LD: lipid droplet; LRP2: low density lipoprotein receptor related protein 2; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MAT: mesenteric adipose tissue; MS: mass spectrometry; MTOR: mechanistic target of rapamycin kinase; MTORC1: MTOR complex 1; NDRG1: N-myc downstream regulated 1; NDUFB5: NADH:ubiquinone oxidoreductase subunit B5; NEFA: non-esterified fatty acid; OA: oleic acid; OCT: optimal cutting temperature; ORO: Oil Red O; PAS: Periodic-acid Schiff; PFA: paraformaldehyde; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PPARA: peroxisome proliferator activated receptor alpha; PPARGC1A: PPARG coactivator 1 alpha; PTEC: proximal tubular epithelial cell; RAB7A: RAB7A, member RAS oncogene family; RPS6: ribosomal protein S6; RPS6KB1: ribosomal protein S6 kinase B1; RT: reverse transcription; RUBCN: rubicon autophagy regulator; SAT: subcutaneous adipose tissue; SFC: supercritical fluid chromatography; SQSTM1: sequestosome 1; SREBF1: sterol regulatory element binding transcription factor 1; SV-40: simian virus-40; TFEB: transcription factor EB; TG: triglyceride; TS: tissue specific; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling; UN: urea nitrogen; UQCRB: ubiquinol-cytochrome c reductase binding protein; UVRAG: UV radiation resistance associated; VPS: vacuolar protein sorting; WAT: white adipose tissue.	ubiquinol	2349-2358	RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein	Mus musculus	56-61
32641834-11	2020	Collectively, our findings indicate that tumour growth requires the ETC to oxidize ubiquinol, which is essential to drive the oxidative TCA cycle and DHODH activity.	ubiquinol	83-92	dihydroorotate dehydrogenase (quinone)	Homo sapiens	150-155
31923624-0	2020	The activity of the DNA repair enzyme hOGG1 can be directly modulated by ubiquinol.	ubiquinol	73-82	8-oxoguanine DNA glycosylase	Homo sapiens	38-43
31923624-7	2020	However, it is suspected that the amount of the 8-oxoguanine DNA glycosylase can be actively regulated on the level of gene expression by the redox-active properties of ubiquinol and thus its protein expression can be controlled.	ubiquinol	169-178	8-oxoguanine DNA glycosylase	Homo sapiens	48-76
31923624-8	2020	Using an real-time base excision repair assay including a melting curve analysis, the activity of the human 8-oxoguanine DNA glycosylase 1 was measured under the influence of ubiquinol.	ubiquinol	175-184	8-oxoguanine DNA glycosylase	Homo sapiens	108-136
31923624-9	2020	It was possible to observe a concentration-dependent increase in the activity of the 8-oxoguanine DNA glycosylase 1 under the influence of ubiquinol for the first time, both on purified and commercially acquired enzyme as well as on enzyme isolated from mitochondria of human fibroblasts.	ubiquinol	139-148	8-oxoguanine DNA glycosylase	Homo sapiens	85-113
31923624-12	2020	However, there was a change in bifunctionality in favor of an increased N-glycosylase activity and a direct interaction between ubiquinol and 8-oxoguanine DNA glycosylase 1.	ubiquinol	128-137	8-oxoguanine DNA glycosylase	Homo sapiens	142-170
31923624-13	2020	We suggest that ubiquinol contributes to the dissolution of a human 8-oxoguanine DNA glycosylase 1 end-product complex that forms after cutting into the sugar-phosphate backbone of the DNA with the resulting unsaturated 3"-phospho-alpha, beta-aldehyde end and thereby inhibits further enzymatic steps.	ubiquinol	16-25	8-oxoguanine DNA glycosylase	Homo sapiens	68-96
32041223-6	2020	Red blood cells (RBC), hematocrit, hemoglobin, VEGF, NO, EGF, IL-1ra, and IL-10 increased in the ubiquinol group while IL-1, IL-8, and MCP-1 decreased.	ubiquinol	97-106	vascular endothelial growth factor A	Homo sapiens	47-51
32041223-6	2020	Red blood cells (RBC), hematocrit, hemoglobin, VEGF, NO, EGF, IL-1ra, and IL-10 increased in the ubiquinol group while IL-1, IL-8, and MCP-1 decreased.	ubiquinol	97-106	epidermal growth factor	Homo sapiens	48-51
32641834-5	2020	Mitochondrial complexes I and II donate electrons to ubiquinone, resulting in the generation of ubiquinol and the regeneration of the NAD+ and FAD cofactors, and complex III oxidizes ubiquinol back to ubiquinone, which also serves as an electron acceptor for dihydroorotate dehydrogenase (DHODH)-an enzyme necessary for de novo pyrimidine synthesis.	ubiquinol	183-192	dihydroorotate dehydrogenase (quinone)	Homo sapiens	259-287
32641834-5	2020	Mitochondrial complexes I and II donate electrons to ubiquinone, resulting in the generation of ubiquinol and the regeneration of the NAD+ and FAD cofactors, and complex III oxidizes ubiquinol back to ubiquinone, which also serves as an electron acceptor for dihydroorotate dehydrogenase (DHODH)-an enzyme necessary for de novo pyrimidine synthesis.	ubiquinol	183-192	dihydroorotate dehydrogenase (quinone)	Homo sapiens	289-294
31974161-6	2020	Immunoprecipitation with an antibody that recognizes the ND1 subunit of RCI co-precipitated a number of proteins implicated in FeS cluster assembly and newly synthesized ubiquinol-cytochrome C reductase Rieske iron-sulfur polypeptide 1 (UQCRFS1), the Rieske FeS protein in RCIII, reflecting some coordination between RCI and RCIII assemblies.	ubiquinol	170-179	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	57-60
32041223-6	2020	Red blood cells (RBC), hematocrit, hemoglobin, VEGF, NO, EGF, IL-1ra, and IL-10 increased in the ubiquinol group while IL-1, IL-8, and MCP-1 decreased.	ubiquinol	97-106	interleukin 10	Homo sapiens	74-79
32041223-6	2020	Red blood cells (RBC), hematocrit, hemoglobin, VEGF, NO, EGF, IL-1ra, and IL-10 increased in the ubiquinol group while IL-1, IL-8, and MCP-1 decreased.	ubiquinol	97-106	interleukin 1 alpha	Homo sapiens	62-66
32041223-8	2020	During exercise, RBC, hemoglobin, hematocrit, VEGF, and EGF increased in ubiquinol group, revealing a possible pro-angiogenic effect, improving oxygen supply and exerting a possible protective effect on other physiological alterations.	ubiquinol	73-82	vascular endothelial growth factor A	Homo sapiens	46-50
32041223-8	2020	During exercise, RBC, hemoglobin, hematocrit, VEGF, and EGF increased in ubiquinol group, revealing a possible pro-angiogenic effect, improving oxygen supply and exerting a possible protective effect on other physiological alterations.	ubiquinol	73-82	epidermal growth factor	Homo sapiens	47-50
29380912-8	2018	We found when ubiquinol was administered before or after TBI, rats had an acute reduction in brain mitochondrial damage, apoptosis, and two serum biomarkers of TBI severity, glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1).	ubiquinol	14-23	glial fibrillary acidic protein	Rattus norvegicus	174-205
31537648-4	2019	Cbp3 consists of two distinct domains, an N-terminal domain present in mitochondrial Cbp3 homologs, and a highly conserved C-terminal domain comprising a ubiquinol-cytochrome c chaperone region.	ubiquinol	154-163	Cbp3p	Saccharomyces cerevisiae S288C	0-4
30968134-1	2019	Plant mitochondria possess two different pathways for electron transport from ubiquinol: the cytochrome pathway and the alternative oxidase (AOX) pathway.	ubiquinol	78-87	acyl-CoA oxidase 1	Homo sapiens	120-139
30968134-1	2019	Plant mitochondria possess two different pathways for electron transport from ubiquinol: the cytochrome pathway and the alternative oxidase (AOX) pathway.	ubiquinol	78-87	acyl-CoA oxidase 1	Homo sapiens	141-144
30107910-5	2018	While the ubiquinol treatment significantly decreased active Bax protein expression in the ischemic retina, phosphorylation of Bad at serine 112 and Bcl-xL protein expression were preserved in the ubiquinol-treated ischemic retina at 12 h. Consistently, the ubiquinol treatment prevented apoptotic cell death by blocking caspase-3 cleavage.	ubiquinol	10-19	BCL2-associated X protein	Mus musculus	61-64
30107910-5	2018	While the ubiquinol treatment significantly decreased active Bax protein expression in the ischemic retina, phosphorylation of Bad at serine 112 and Bcl-xL protein expression were preserved in the ubiquinol-treated ischemic retina at 12 h. Consistently, the ubiquinol treatment prevented apoptotic cell death by blocking caspase-3 cleavage.	ubiquinol	197-206	BCL2-associated X protein	Mus musculus	61-64
30107910-5	2018	While the ubiquinol treatment significantly decreased active Bax protein expression in the ischemic retina, phosphorylation of Bad at serine 112 and Bcl-xL protein expression were preserved in the ubiquinol-treated ischemic retina at 12 h. Consistently, the ubiquinol treatment prevented apoptotic cell death by blocking caspase-3 cleavage.	ubiquinol	197-206	BCL2-like 1	Mus musculus	149-155
30107910-5	2018	While the ubiquinol treatment significantly decreased active Bax protein expression in the ischemic retina, phosphorylation of Bad at serine 112 and Bcl-xL protein expression were preserved in the ubiquinol-treated ischemic retina at 12 h. Consistently, the ubiquinol treatment prevented apoptotic cell death by blocking caspase-3 cleavage.	ubiquinol	197-206	caspase 3	Mus musculus	321-330
30107910-5	2018	While the ubiquinol treatment significantly decreased active Bax protein expression in the ischemic retina, phosphorylation of Bad at serine 112 and Bcl-xL protein expression were preserved in the ubiquinol-treated ischemic retina at 12 h. Consistently, the ubiquinol treatment prevented apoptotic cell death by blocking caspase-3 cleavage.	ubiquinol	197-206	BCL2-associated X protein	Mus musculus	61-64
30107910-5	2018	While the ubiquinol treatment significantly decreased active Bax protein expression in the ischemic retina, phosphorylation of Bad at serine 112 and Bcl-xL protein expression were preserved in the ubiquinol-treated ischemic retina at 12 h. Consistently, the ubiquinol treatment prevented apoptotic cell death by blocking caspase-3 cleavage.	ubiquinol	197-206	BCL2-like 1	Mus musculus	149-155
30107910-5	2018	While the ubiquinol treatment significantly decreased active Bax protein expression in the ischemic retina, phosphorylation of Bad at serine 112 and Bcl-xL protein expression were preserved in the ubiquinol-treated ischemic retina at 12 h. Consistently, the ubiquinol treatment prevented apoptotic cell death by blocking caspase-3 cleavage.	ubiquinol	197-206	caspase 3	Mus musculus	321-330
30107910-6	2018	These results suggest that the ubiquinol enhances RGC survival by modulating the Bax/Bad/Bcl-xL-mediated apoptotic pathway in the ischemic retina.	ubiquinol	31-40	BCL2-associated X protein	Mus musculus	81-84
30107910-6	2018	These results suggest that the ubiquinol enhances RGC survival by modulating the Bax/Bad/Bcl-xL-mediated apoptotic pathway in the ischemic retina.	ubiquinol	31-40	BCL2-like 1	Mus musculus	89-95
31545417-1	2019	Previously, a ubiquinol-cytochrome c reductase binding protein (UQCRB) homolog was identified in the house dust mite (HDM) species Dermatophagoides farinae (Der f) as a major allergen.	ubiquinol	14-23	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	64-69
31634899-8	2019	We further demonstrate that ferroptosis suppression by FSP1 is mediated via ubiquinone (CoQ10): its reduced form ubiquinol traps lipid peroxyl radicals that mediate lipid peroxidation, while FSP1 catalyses its regeneration by using NAD(P)H.	ubiquinol	113-122	S100 calcium binding protein A4	Homo sapiens	55-59
31622418-14	2019	The FBA simulations were able to reproduce the deleterious effect of MCHM on cellular growth and suggest that the effect of MCHM on ubiquinol:ferricytochrome c reductase reaction, caused by the under-expression of CYT1 gene, could be the driven force behind the observed effect on yeast metabolism and growth.	ubiquinol	132-141	ubiquinol--cytochrome-c reductase catalytic subunit CYT1	Saccharomyces cerevisiae S288C	214-218
31218852-1	2019	The mitochondrial alternative oxidase, AOX, present in most eukaryotes apart from vertebrates and insects, catalyzes the direct oxidation of ubiquinol by oxygen, by-passing the terminal proton-motive steps of the respiratory chain.	ubiquinol	141-150	Aldox89A	Drosophila melanogaster	39-42
29851085-1	2018	A simple assay procedure for measuring ATP-dependent reverse electron transfer from ubiquinol to hexaammineruthenium (III) (HAR) catalyzed by mitochondrial respiratory complex I is introduced.	ubiquinol	84-93	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	124-127
29380912-8	2018	We found when ubiquinol was administered before or after TBI, rats had an acute reduction in brain mitochondrial damage, apoptosis, and two serum biomarkers of TBI severity, glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1).	ubiquinol	14-23	glial fibrillary acidic protein	Rattus norvegicus	207-211
29380912-8	2018	We found when ubiquinol was administered before or after TBI, rats had an acute reduction in brain mitochondrial damage, apoptosis, and two serum biomarkers of TBI severity, glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1).	ubiquinol	14-23	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	217-250
29380912-8	2018	We found when ubiquinol was administered before or after TBI, rats had an acute reduction in brain mitochondrial damage, apoptosis, and two serum biomarkers of TBI severity, glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1).	ubiquinol	14-23	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	252-258
28967163-2	2018	The mammalian CIII comprises 11 subunits among which cytochrome b is central in the catalytic core, where oxidation of ubiquinol occurs at the Qo site.	ubiquinol	119-128	mitochondrially encoded cytochrome b	Homo sapiens	53-65
27987212-1	2017	The plant mitochondrial electron transport chain (ETC) is bifurcated such that electrons from ubiquinol are passed to oxygen via the usual cytochrome path or through alternative oxidase (AOX).	ubiquinol	94-103	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	166-185
28978450-2	2017	It funnels electrons coming from NADH and ubiquinol to cytochrome c, but it is also capable of producing significant amounts of the free radical superoxide.	ubiquinol	42-51	cytochrome c, somatic	Homo sapiens	55-67
28811612-5	2017	CoQ10H2 also regulated the activity of the transcription factor C-FOS and inhibited gene expression of PDE4, a cAMP-degrading enzyme, via the CaMKII-MEK1/2-ERK1/2 signaling pathway, thereby increasing intracellular cAMP.	ubiquinol	0-7	FBJ osteosarcoma oncogene	Mus musculus	64-69
28811612-5	2017	CoQ10H2 also regulated the activity of the transcription factor C-FOS and inhibited gene expression of PDE4, a cAMP-degrading enzyme, via the CaMKII-MEK1/2-ERK1/2 signaling pathway, thereby increasing intracellular cAMP.	ubiquinol	0-7	mitogen-activated protein kinase 3	Mus musculus	156-162
29107420-0	2017	African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase.	ubiquinol	78-87	sarcosine dehydrogenase	Homo sapiens	41-44
27987212-1	2017	The plant mitochondrial electron transport chain (ETC) is bifurcated such that electrons from ubiquinol are passed to oxygen via the usual cytochrome path or through alternative oxidase (AOX).	ubiquinol	94-103	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	187-190
28702034-12	2017	Alternative oxidase (AOX), the terminal oxidase of the cyanide (CN)-resistant alternative respiratory pathway, catalyze oxygen-dependent oxidation of ubiquinol in plants.	ubiquinol	150-159	acyl-CoA oxidase 1	Homo sapiens	0-19
28702034-12	2017	Alternative oxidase (AOX), the terminal oxidase of the cyanide (CN)-resistant alternative respiratory pathway, catalyze oxygen-dependent oxidation of ubiquinol in plants.	ubiquinol	150-159	acyl-CoA oxidase 1	Homo sapiens	21-24
28088729-2	2017	AOX branches from the main respiratory chain, directly coupling the oxidation of ubiquinol with reduction of oxygen to water.	ubiquinol	81-90	uncharacterized protein	Chlamydomonas reinhardtii	0-3
28150130-0	2017	Three-Year Follow-Up of High-Dose Ubiquinol Supplementation in a Case of Familial Multiple System Atrophy with Compound Heterozygous COQ2 Mutations.	ubiquinol	34-43	coenzyme Q2, polyprenyltransferase	Homo sapiens	133-137
28150130-1	2017	We report a 3-year follow-up of high-dose ubiquinol supplementation in a case of familial multiple system atrophy (MSA) with compound heterozygous nonsense (R387X) and missense (V393A) mutations in COQ2.	ubiquinol	42-51	coenzyme Q2, polyprenyltransferase	Homo sapiens	198-202
28150130-5	2017	It also suggests the therapeutic potential of ubiquinol for patients with MSA with COQ2 mutations.	ubiquinol	46-55	coenzyme Q2, polyprenyltransferase	Homo sapiens	83-87
27816999-2	2016	AOX directly accepts electrons from ubiquinol and is therefore capable of bypassing ETS Complexes III and IV.	ubiquinol	36-45	alternative oxidase, mitochondrial-like	Crassostrea gigas	0-3
27758861-2	2016	The function of cyt bc1 is to couple the reaction of electron transfer from ubiquinol to cytochrome c to proton pumping across the membrane.	ubiquinol	76-85	cytochrome c, somatic	Homo sapiens	89-101
25008109-1	2014	Complex III (cytochrome bc1) is a protein complex of the mitochondrial inner membrane that transfers electrons from ubiquinol to cytochrome c.	ubiquinol	116-125	cytochrome c, somatic	Homo sapiens	129-141
26616144-1	2016	During dark-induced senescence isovaleryl-CoA dehydrogenase (IVDH) and D-2-hydroxyglutarate dehydrogenase (D-2HGDH) act as alternate electron donors to the ubiquinol pool via the electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase (ETF/ETFQO) pathway.	ubiquinol	156-165	isovaleryl-CoA-dehydrogenase	Arabidopsis thaliana	31-59
26616144-1	2016	During dark-induced senescence isovaleryl-CoA dehydrogenase (IVDH) and D-2-hydroxyglutarate dehydrogenase (D-2HGDH) act as alternate electron donors to the ubiquinol pool via the electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase (ETF/ETFQO) pathway.	ubiquinol	156-165	isovaleryl-CoA-dehydrogenase	Arabidopsis thaliana	61-65
26616144-1	2016	During dark-induced senescence isovaleryl-CoA dehydrogenase (IVDH) and D-2-hydroxyglutarate dehydrogenase (D-2HGDH) act as alternate electron donors to the ubiquinol pool via the electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase (ETF/ETFQO) pathway.	ubiquinol	156-165	FAD-linked oxidases family protein	Arabidopsis thaliana	71-105
26616144-1	2016	During dark-induced senescence isovaleryl-CoA dehydrogenase (IVDH) and D-2-hydroxyglutarate dehydrogenase (D-2HGDH) act as alternate electron donors to the ubiquinol pool via the electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase (ETF/ETFQO) pathway.	ubiquinol	156-165	FAD-linked oxidases family protein	Arabidopsis thaliana	107-114
26616144-1	2016	During dark-induced senescence isovaleryl-CoA dehydrogenase (IVDH) and D-2-hydroxyglutarate dehydrogenase (D-2HGDH) act as alternate electron donors to the ubiquinol pool via the electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase (ETF/ETFQO) pathway.	ubiquinol	156-165	electron-transfer flavoprotein:ubiquinone oxidoreductase	Arabidopsis thaliana	272-277
26910885-10	2016	Here it was discovered that the ubiquinol status significantly correlated to the concentration of the inflammation marker monocyte chemotactic protein 1.	ubiquinol	32-41	C-C motif chemokine ligand 2	Homo sapiens	122-152
27776780-7	2016	Similar to AOX, an ubiquinol (UQH2) oxidase, PTOX is a plastoquinol (PQH2) oxidase on the chloroplast thylakoid membrane.	ubiquinol	19-28	alternative oxidase 2	Arabidopsis thaliana	11-14
27776780-7	2016	Similar to AOX, an ubiquinol (UQH2) oxidase, PTOX is a plastoquinol (PQH2) oxidase on the chloroplast thylakoid membrane.	ubiquinol	19-28	Alternative oxidase family protein	Arabidopsis thaliana	45-49
26438244-1	2015	Alternative oxidase (AOX) is a diiron carboxylate protein present in all plants examined to date that couples the oxidation of ubiquinol with the reduction of oxygen to water.	ubiquinol	127-136	acyl-CoA oxidase 1	Homo sapiens	0-19
26438244-1	2015	Alternative oxidase (AOX) is a diiron carboxylate protein present in all plants examined to date that couples the oxidation of ubiquinol with the reduction of oxygen to water.	ubiquinol	127-136	acyl-CoA oxidase 1	Homo sapiens	21-24
27194483-3	2016	The ubiquinol oxidation Qo site of cytochrome bc1 (mitochondrial complex III, cytochrome b6f in plants) has been considered an exception with catalytic reactions assumed to involve highly unstable SQ or not to involve any SQ intermediate.	ubiquinol	4-13	mitochondrially encoded cytochrome b	Homo sapiens	35-47
26429200-9	2016	In ubiquinol supplementation group, alanine aminotransferase and alkaline phosphatase were significantly down-regulated after 12 weeks and changes in miR-15a, miR-21 and miR-33a were negatively correlated with alkaline phosphatase (p < 0.05).	ubiquinol	3-12	glutamic--pyruvic transaminase	Homo sapiens	36-60
26429200-9	2016	In ubiquinol supplementation group, alanine aminotransferase and alkaline phosphatase were significantly down-regulated after 12 weeks and changes in miR-15a, miR-21 and miR-33a were negatively correlated with alkaline phosphatase (p < 0.05).	ubiquinol	3-12	microRNA 15a	Homo sapiens	150-157
26429200-9	2016	In ubiquinol supplementation group, alanine aminotransferase and alkaline phosphatase were significantly down-regulated after 12 weeks and changes in miR-15a, miR-21 and miR-33a were negatively correlated with alkaline phosphatase (p < 0.05).	ubiquinol	3-12	microRNA 21	Homo sapiens	159-165
26429200-9	2016	In ubiquinol supplementation group, alanine aminotransferase and alkaline phosphatase were significantly down-regulated after 12 weeks and changes in miR-15a, miR-21 and miR-33a were negatively correlated with alkaline phosphatase (p < 0.05).	ubiquinol	3-12	microRNA 33a	Homo sapiens	170-177
28132468-2	2016	This enzyme catalyses electron transfer from ubiquinol to cytochrome c coupled to translocation of protons across the membrane, which contributes to generation of protonmotive force utilized for ATP production.	ubiquinol	45-54	cytochrome c, somatic	Homo sapiens	58-70
25728634-8	2015	Interestingly, ubiquinol supplementation (150 mg/day; 14 day; n = 53) slightly reduces the expression of CLCN6, a gene related to NT-proBNP level.	ubiquinol	15-24	chloride voltage-gated channel 6	Homo sapiens	105-110
23688079-2	2014	Unfortunately, the mechanism of resistance is a multivariate problem, including primarily mutations in the gene of the cytochrome b subunit but also activation of alternative pathways of ubiquinol oxidation and pharmacokinetic effects.	ubiquinol	187-196	mitochondrially encoded cytochrome b	Homo sapiens	119-131
24457019-5	2014	Changes in HMW-adiponectin, ubiquinol/LDL-C ratios and hs-CRP were significantly correlated with changes in eGFR (r=0.597, p=0.001; r=0.437, p=0.02; and r=-0.473, p=0.01, respectively).	ubiquinol	28-37	epidermal growth factor receptor	Homo sapiens	108-112
24661880-2	2014	It blocks electron transfer from ubiquinol to cytochrome b and thus inhibits CIII activity.	ubiquinol	33-42	cytochrome b, mitochondrial	Mus musculus	46-58
22985600-2	2013	Based on X-ray crystallographic studies of cytochrome bc1, a mechanism has been proposed in which the extrinsic domain of the iron-sulfur protein first binds to cytochrome b where it accepts an electron from ubiquinol in the Qo site, and then rotates by 57  to a position close to cytochrome c1 where it transfers an electron to cytochrome c1.	ubiquinol	208-217	mitochondrially encoded cytochrome b	Homo sapiens	43-55
23201476-2	2013	The bc1 complex catalyzes the reaction of transferring electrons from the low potential substrate ubiquinol to high potential cytochrome c.	ubiquinol	98-107	cytochrome c, somatic	Homo sapiens	126-138
21458815-10	2011	There was a significant positive correlation between changes in ubiquinol and ApoA1 (r=0.518, p=0.005).	ubiquinol	64-73	apolipoprotein A1	Homo sapiens	78-83
23453781-1	2013	Succinate dehydrogenase (SDH) oxidises succinate to fumarate as a component of the tricarboxylic acid cycle and ubiquinone to ubiquinol in the mitochondrial electron transport chain.	ubiquinol	126-135	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-23
23453781-1	2013	Succinate dehydrogenase (SDH) oxidises succinate to fumarate as a component of the tricarboxylic acid cycle and ubiquinone to ubiquinol in the mitochondrial electron transport chain.	ubiquinol	126-135	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	25-28
23021568-4	2012	FINDINGS: Ubiquinol decreases the expression of the pro-inflammatory chemokine (C-X-C motif) ligand 2 gene (CXCL2) more than 10-fold.	ubiquinol	10-19	C-X-C motif chemokine ligand 2	Homo sapiens	108-113
23021568-5	2012	Bisulfite-/ MALDI-TOF-based analysis of regulatory regions of the CXCL2 gene identified six adjacent CpG islands which showed a 3.4-fold decrease of methylation status after ubiquinol supplementation.	ubiquinol	174-183	C-X-C motif chemokine ligand 2	Homo sapiens	66-71
23021568-6	2012	This effect seems to be rather gene specific, because ubiquinol reduced the expression of two other pro-inflammatory genes (PMAIP1, MMD) without changing the methylation pattern of the respective gene.	ubiquinol	54-63	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	124-130
23021568-7	2012	CONCLUSION: In conclusion, ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory CXCL2 gene in humans.	ubiquinol	27-36	C-X-C motif chemokine ligand 2	Homo sapiens	112-117
22448092-0	2012	Ubiquinol affects the expression of genes involved in PPARalpha signalling and lipid metabolism without changes in methylation of CpG promoter islands in the liver of mice.	ubiquinol	0-9	peroxisome proliferator activated receptor alpha	Mus musculus	54-63
22448092-6	2012	Text mining and GeneOntology analysis revealed that the "top 20" ubiquinol-regulated genes play a role in lipid metabolism and are functionally connected by the PPARalpha signalling pathway.	ubiquinol	65-74	peroxisome proliferator activated receptor alpha	Mus musculus	161-170
22448092-7	2012	With regard to the ubiquinol-induced changes in gene expression of about +3.14-fold (p<=0.05), +2.18-fold (p<=0.01), and -2.13-fold (p<=0.05) for ABCA1, ACYP1, and ACSL1 genes, respectively, hepatic DNA methylation analysis of 282 (sense orientation) and 271 (antisense) CpG units in the respective promoter islands revealed no significant effect of ubiquinol.	ubiquinol	19-28	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	155-160
22448092-7	2012	With regard to the ubiquinol-induced changes in gene expression of about +3.14-fold (p<=0.05), +2.18-fold (p<=0.01), and -2.13-fold (p<=0.05) for ABCA1, ACYP1, and ACSL1 genes, respectively, hepatic DNA methylation analysis of 282 (sense orientation) and 271 (antisense) CpG units in the respective promoter islands revealed no significant effect of ubiquinol.	ubiquinol	19-28	acylphosphatase 1, erythrocyte (common) type	Mus musculus	162-167
22448092-7	2012	With regard to the ubiquinol-induced changes in gene expression of about +3.14-fold (p<=0.05), +2.18-fold (p<=0.01), and -2.13-fold (p<=0.05) for ABCA1, ACYP1, and ACSL1 genes, respectively, hepatic DNA methylation analysis of 282 (sense orientation) and 271 (antisense) CpG units in the respective promoter islands revealed no significant effect of ubiquinol.	ubiquinol	19-28	acyl-CoA synthetase long-chain family member 1	Mus musculus	173-178
22448092-8	2012	In conclusion, ubiquinol affects the expression of genes involved in PPARalpha signalling and lipid metabolism without changing the promoter DNA methylation status in the liver of mice.	ubiquinol	15-24	peroxisome proliferator activated receptor alpha	Mus musculus	69-78
24116043-8	2013	Furthermore, in batch cultures of a strain that contains ubiquinone as its only quinone species, we observed that the ArcA phosphorylation level closely followed the redox state of the ubiquinone/ubiquinol pool, much more strictly than it does in the wild type strain.	ubiquinol	196-205	arginine deiminase	Escherichia coli	118-122
24116043-9	2013	Therefore, at low rates of oxygen supply in the wild type strain, the activity of ArcB may be inhibited by demethylmenaquinone, in spite of the fact that the ubiquinones are present in the ubiquinol form.	ubiquinol	189-198	hypothetical protein	Escherichia coli	82-86
23870256-0	2013	Analysis of the kinetics and bistability of ubiquinol:cytochrome c oxidoreductase.	ubiquinol	44-53	cytochrome c, somatic	Homo sapiens	54-66
23870256-1	2013	Ubiquinol:cytochrome c oxidoreductase, bc1 complex, is the enzyme in the respiratory chain of mitochondria responsible for the transfer reducing potential from ubiquinol to cytochrome c coupled to the movement of charge against the electrostatic potential across the mitochondrial inner membrane.	ubiquinol	0-9	cytochrome c, somatic	Homo sapiens	10-22
23870256-1	2013	Ubiquinol:cytochrome c oxidoreductase, bc1 complex, is the enzyme in the respiratory chain of mitochondria responsible for the transfer reducing potential from ubiquinol to cytochrome c coupled to the movement of charge against the electrostatic potential across the mitochondrial inner membrane.	ubiquinol	0-9	cytochrome c, somatic	Homo sapiens	173-185
23870256-1	2013	Ubiquinol:cytochrome c oxidoreductase, bc1 complex, is the enzyme in the respiratory chain of mitochondria responsible for the transfer reducing potential from ubiquinol to cytochrome c coupled to the movement of charge against the electrostatic potential across the mitochondrial inner membrane.	ubiquinol	160-169	cytochrome c, somatic	Homo sapiens	10-22
23870256-1	2013	Ubiquinol:cytochrome c oxidoreductase, bc1 complex, is the enzyme in the respiratory chain of mitochondria responsible for the transfer reducing potential from ubiquinol to cytochrome c coupled to the movement of charge against the electrostatic potential across the mitochondrial inner membrane.	ubiquinol	160-169	cytochrome c, somatic	Homo sapiens	173-185
23487766-2	2013	AOX is a diiron carboxylate protein that catalyzes the four-electron reduction of dioxygen to water by ubiquinol.	ubiquinol	103-112	acyl-CoA oxidase 1	Homo sapiens	0-3
23300486-2	2013	It results from the activity of an alternative oxidase (AOX) that conveys electrons directly from the respiratory chain (RC) ubiquinol pool to oxygen.	ubiquinol	125-134	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	35-54
23300486-2	2013	It results from the activity of an alternative oxidase (AOX) that conveys electrons directly from the respiratory chain (RC) ubiquinol pool to oxygen.	ubiquinol	125-134	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	56-59
22554985-5	2012	The two b hemes of complex III participate in the unique bifurcation of electron flow from the oxidation of ubiquinol, while heme c of the cytochrome c subunit, Cyt1, transfers these electrons to the peripheral cytochrome c.	ubiquinol	108-117	cytochrome c, somatic	Homo sapiens	139-151
21866942-3	2011	The resultant amino acid mutations, A122T and Y126C, reside within helix C in the ubiquinol-binding pocket of cytochrome b, an essential subunit of the cytochrome bc(1) complex.	ubiquinol	82-91	CYTB	Plasmodium falciparum	110-122
21866942-7	2011	The basis for this difference was revealed by molecular docking studies, in which both of these inhibitors were shown to have distinctly different modes of binding within the ubiquinol-binding site of cytochrome b.	ubiquinol	175-184	CYTB	Plasmodium falciparum	201-213
21458815-11	2011	Multivariate regression analysis showed that changes in ubiquinol correlated significantly with changes in ApoA1 after adjusting for age, sex, body mass index, and smoking (beta=0.502, p=0.008).	ubiquinol	56-65	apolipoprotein A1	Homo sapiens	107-112
21187048-2	2010	It links the electrons transfer from ubiquinol (or coenzyme Q) to cytochrome c and proton translocation across the inner mitochondrial membrane.	ubiquinol	37-46	cytochrome c, somatic	Homo sapiens	66-78
20878200-6	2011	However, ubiquinol decreased SBP (143.9 +- 29.0 mmHg, p < 0.05), u-alb (256.1 +- 122.1 microg/day, p < 0.02), and renal superoxide production (877.8 +- 195.6 RLU/g kidney, p < 0.01), associated with an increase in renal ubiquinol levels.	ubiquinol	9-18	albumin	Homo sapiens	70-73
20085745-0	2010	Ubiquinol-binding site in the alternative oxidase: mutagenesis reveals features important for substrate binding and inhibition.	ubiquinol	0-9	acyl-CoA oxidase 1	Homo sapiens	30-49
20085745-3	2010	Bioinformatic searches revealed that, within a putative ubiquinol-binding crevice in AOX, Gln242, Asn247, Tyr253, Ser256, His261 and Arg262 were highly conserved.	ubiquinol	56-65	acyl-CoA oxidase 1	Homo sapiens	85-88
20085745-8	2010	These results provide important new insights into the ubiquinol-binding site of the alternative oxidase, the identity of which maybe important for future rational drug design.	ubiquinol	54-63	acyl-CoA oxidase 1	Homo sapiens	84-103
21086475-3	2010	Microarray analyses in liver tissues of SAMP1 mice identified 946 genes as differentially expressed between ubiquinol-treated and control animals (>=1.5-fold, P < 0.05).	ubiquinol	108-117	transmembrane protein 201	Mus musculus	40-45
21086475-4	2010	Text mining analyses revealed for a part of the ubiquinol-regulated genes, a functional connection in PPARalpha and LXR/RXR signalling pathways.	ubiquinol	48-57	peroxisome proliferator activated receptor alpha	Mus musculus	102-111
21086475-4	2010	Text mining analyses revealed for a part of the ubiquinol-regulated genes, a functional connection in PPARalpha and LXR/RXR signalling pathways.	ubiquinol	48-57	nuclear receptor subfamily 1, group H, member 3	Mus musculus	116-119
21086475-6	2010	We found a significant increase of desmosterol (2.0-fold, P < 0.001) in the liver of ubiquinol-supplemented SAMP1 mice when related to control animals.	ubiquinol	88-97	transmembrane protein 201	Mus musculus	111-116
20501910-7	2010	Our results aid in the elucidation of the pathway of plant Lys catabolism and demonstrate that both isovaleryl-CoA dehydrogenase and 2-hydroxyglutarate dehydrogenase act as electron donors to the ubiquinol pool via an ETF/ETFQO-mediated route.	ubiquinol	196-205	isovaleryl-CoA-dehydrogenase	Arabidopsis thaliana	100-128
20518072-1	2010	ENOX2 (tNOX), a tumor-associated cell surface ubiquinol (NADH) oxidase, functions as an alternative terminal oxidase for plasma membrane electron transport.	ubiquinol	46-55	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	0-5
20518072-1	2010	ENOX2 (tNOX), a tumor-associated cell surface ubiquinol (NADH) oxidase, functions as an alternative terminal oxidase for plasma membrane electron transport.	ubiquinol	46-55	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	7-11
20371599-5	2010	If this speculation is correct, then one should see more O(2)(*) generation upon oxidation of ubiquinol by a high potential oxidant, such as cytochrome c or ferricyanide, in the presence of phospholipid vesicles or detergent micelles than in the hydrophilic conditions, and this is indeed the case.	ubiquinol	94-103	cytochrome c, somatic	Homo sapiens	141-153
20501910-7	2010	Our results aid in the elucidation of the pathway of plant Lys catabolism and demonstrate that both isovaleryl-CoA dehydrogenase and 2-hydroxyglutarate dehydrogenase act as electron donors to the ubiquinol pool via an ETF/ETFQO-mediated route.	ubiquinol	196-205	electron-transfer flavoprotein:ubiquinone oxidoreductase	Arabidopsis thaliana	222-227
19933363-9	2010	These results lead to the working hypothesis that the in vivo activity of ArcB in E. coli is modulated by the redox state of the menaquinone pool and that the ubiquinone/ubiquinol ratio in vivo surely is not the only determinant of ArcB activity.	ubiquinol	170-179	hypothetical protein	Escherichia coli	74-78
19660431-2	2010	It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket.	ubiquinol	128-137	mitochondrially encoded cytochrome b	Homo sapiens	26-38
19508334-3	2009	Besides cytochrome c oxidase, plant mitochondria have an alternative oxidase (AOX) that accepts electrons directly from ubiquinol, dissipating energy as heat.	ubiquinol	120-129	ubiquinol oxidase 1, mitochondrial	Glycine max	57-76
19508334-3	2009	Besides cytochrome c oxidase, plant mitochondria have an alternative oxidase (AOX) that accepts electrons directly from ubiquinol, dissipating energy as heat.	ubiquinol	120-129	ubiquinol oxidase 1, mitochondrial	Glycine max	78-81
18932012-7	2009	Increased ubiquinol/ubiquinone ratio interferes the function of dihydroorotate dehydrogenase, the only mitochondrial enzyme involved in ubiquinone mediated de novo pyrimidine synthesis.	ubiquinol	10-19	dihydroorotate dehydrogenase	Mus musculus	64-92
19268423-1	2009	This review focuses on the terminal part of the respiratory chain where, macroscopically speaking, electron transfer (ET) switches from the two-electron donor, ubiquinol, to the single-electron carrier, cytochrome c, to finally reduce the four-electron acceptor dioxygen.	ubiquinol	160-169	cytochrome c, somatic	Homo sapiens	203-215
19268423-3	2009	The two relevant enzymes, ubiquinol:cytochrome c oxidoreductase and cytochrome c oxidase, appear as rather diverse modules, differing largely in their design for substrate interaction, internal ET, and moreover, in their mechanisms of energy transduction.	ubiquinol	26-35	cytochrome c, somatic	Homo sapiens	36-48
19268423-3	2009	The two relevant enzymes, ubiquinol:cytochrome c oxidoreductase and cytochrome c oxidase, appear as rather diverse modules, differing largely in their design for substrate interaction, internal ET, and moreover, in their mechanisms of energy transduction.	ubiquinol	26-35	cytochrome c, somatic	Homo sapiens	68-80
19348906-1	2009	Cytochrome b is a pivotal protein subunit of the cytochrome bc(1) complex and forms the ubiquinol oxidation site in the enzyme that is generally thought to be the primary site where electrons are aberrantly diverted from the enzyme, reacting with oxygen to form superoxide anion.	ubiquinol	88-97	cytochrome b	Saccharomyces cerevisiae S288C	0-12
19645667-1	2009	Three forms of horse heart cytochrome c with specific substitutions of heme cleft surface located amino acid residues involved in specific interactions with ubiquinol:cytochrome c reductase (complex III) and cytochrome c oxidase (complex IV) were constructed, and their reactions with superoxide radical produced by NADH:ubiquinone reductase (complex I) were studied.	ubiquinol	157-166	cytochrome c, somatic	Equus caballus	27-39
19645667-1	2009	Three forms of horse heart cytochrome c with specific substitutions of heme cleft surface located amino acid residues involved in specific interactions with ubiquinol:cytochrome c reductase (complex III) and cytochrome c oxidase (complex IV) were constructed, and their reactions with superoxide radical produced by NADH:ubiquinone reductase (complex I) were studied.	ubiquinol	157-166	cytochrome c, somatic	Equus caballus	167-179
19645667-1	2009	Three forms of horse heart cytochrome c with specific substitutions of heme cleft surface located amino acid residues involved in specific interactions with ubiquinol:cytochrome c reductase (complex III) and cytochrome c oxidase (complex IV) were constructed, and their reactions with superoxide radical produced by NADH:ubiquinone reductase (complex I) were studied.	ubiquinol	157-166	cytochrome c, somatic	Equus caballus	167-179
19325183-0	2009	The rate-limiting step in the cytochrome bc1 complex (Ubiquinol-Cytochrome c Oxidoreductase) is not changed by inhibition of cytochrome b-dependent deprotonation: implications for the mechanism of ubiquinol oxidation at center P of the bc1 complex.	ubiquinol	197-206	cytochrome b	Saccharomyces cerevisiae S288C	30-42
18973379-6	2008	In the examination of the mechanism of the ubquinol oxidation, it was confirmed that the ubiquinol docks between the imidazolate of [2Fe-2S] clusters and Glu272(-) of cytochrome b by the hydrogen bonds before the oxidation proceeds, consistent with the experimental proposals.	ubiquinol	89-98	mitochondrially encoded cytochrome b	Homo sapiens	167-179
19390647-6	2009	In liver samples of mice injected with LPS, supplementation with ubiquinol-10 leads to a reduction of LPS-induced miR-146a expression to 78.12 +/- 21.25%.	ubiquinol	65-74	microRNA 146	Mus musculus	114-122
18555833-7	2008	Ubiquinol-10 (beta = .23, P = .007) and CoQ10(total) (beta = .27, P = .009) were predicted by blood selenium; and alpha-tocopherol, by PCB (beta = 4.12, P = .0002), n-3 PUFA (beta = 9.16, P = .02), and OxLDL (beta = 3.04, P = .05).	ubiquinol	0-9	pumilio RNA binding family member 3	Homo sapiens	169-173
18729827-2	2008	These mice displayed specific but variable reduction of ubiquinol-cytochrome c reductase complex activity in mitochondria of heart, liver and skeletal muscle due to a decrease in the expression of mitochondrial DNA-encoded cytochrome b, the catalytic core of the complex.	ubiquinol	56-65	cytochrome b, mitochondrial	Mus musculus	223-235
18793182-1	2008	The AOX (alternative oxidase) is a non-protonmotive ubiquinol-oxygen oxidoreductase that couples the oxidation of ubiquinol with the complete reduction of water.	ubiquinol	52-61	acyl-CoA oxidase 1	Homo sapiens	4-7
18793182-1	2008	The AOX (alternative oxidase) is a non-protonmotive ubiquinol-oxygen oxidoreductase that couples the oxidation of ubiquinol with the complete reduction of water.	ubiquinol	52-61	acyl-CoA oxidase 1	Homo sapiens	9-28
18793182-1	2008	The AOX (alternative oxidase) is a non-protonmotive ubiquinol-oxygen oxidoreductase that couples the oxidation of ubiquinol with the complete reduction of water.	ubiquinol	52-61	thioredoxin reductase 1	Homo sapiens	69-83
18522938-4	2008	Here we show that superoxide formation at the ubiquinol oxidation center of the membrane-bound or purified cytochrome bc(1) complex is stimulated by the presence of oxidized ubiquinone indicating that in a reverse reaction the electron is transferred onto oxygen from reduced cytochrome b(L) via ubiquinone rather than during the forward ubiquinone cycle reaction.	ubiquinol	46-55	mitochondrially encoded cytochrome b	Homo sapiens	107-119
17336955-7	2007	RESULTS: Plasma ubiquinol-10 to low-density lipoprotein cholesterol (LDL-C) ratios in patients with different angiographic findings have been found as 180+/-69 and 132+/-43, respectively (p=0.020).	ubiquinol	16-25	component of oligomeric golgi complex 2	Homo sapiens	32-67
18774933-1	2008	The kinetics of the ubiquinol-cytochrome c reductase reaction was examined using membrane fragments and purified bc(1) complexes derived from a wild-type (WT) and a newly constructed mutant (MUT) strains of Paracoccus denitrificans.	ubiquinol	20-29	cytochrome c, somatic	Homo sapiens	30-42
17336955-7	2007	RESULTS: Plasma ubiquinol-10 to low-density lipoprotein cholesterol (LDL-C) ratios in patients with different angiographic findings have been found as 180+/-69 and 132+/-43, respectively (p=0.020).	ubiquinol	16-25	component of oligomeric golgi complex 2	Homo sapiens	69-74
17336955-8	2007	The ubiquinol-10/LDL-C ratio was significantly lower in angiographically positive patients.	ubiquinol	4-13	component of oligomeric golgi complex 2	Homo sapiens	17-22
17336955-13	2007	Our results indicate that the ratio of ubiquinol-10/LDL-C is likely to be a risk factor for atherogenesis.	ubiquinol	39-48	component of oligomeric golgi complex 2	Homo sapiens	52-57
16600173-1	2006	The Q-cycle mechanism of the bc1 complex explains how the electron transfer from ubihydroquinone (quinol, QH2) to cytochrome (cyt) c (or c2 in bacteria) is coupled to the pumping of protons across the membrane.	ubiquinol	106-109	cytochrome c, somatic	Homo sapiens	114-132
17234684-6	2007	But a significant loss in the ubiquinol-cytochrome c reducing activity was not observed in the EEDQ-treated bc1 complex.	ubiquinol	30-39	LOC104968582	Bos taurus	40-52
17050691-14	2006	In both cases, when ETF-QO is reduced to a two-electron reduced state (one electron at each redox center), the enzyme is primed to reduce UQ to ubiquinol via FAD.	ubiquinol	144-153	electron transfer flavoprotein dehydrogenase	Homo sapiens	20-26
17383607-1	2007	Hydroxy-naphthoquinones are competitive inhibitors of the cytochrome bc(1) complex that bind to the ubiquinol oxidation site between cytochrome b and the iron-sulfur protein and presumably mimic a transition state in the ubiquinol oxidation reaction catalyzed by the enzyme.	ubiquinol	100-109	cytochrome b	Saccharomyces cerevisiae S288C	58-70
17383607-1	2007	Hydroxy-naphthoquinones are competitive inhibitors of the cytochrome bc(1) complex that bind to the ubiquinol oxidation site between cytochrome b and the iron-sulfur protein and presumably mimic a transition state in the ubiquinol oxidation reaction catalyzed by the enzyme.	ubiquinol	221-230	cytochrome b	Saccharomyces cerevisiae S288C	58-70
17145759-0	2007	Mutational analysis of cytochrome b at the ubiquinol oxidation site of yeast complex III.	ubiquinol	43-52	cytochrome b	Saccharomyces cerevisiae S288C	23-35
16387461-4	2006	Supplementation with reduced CoQ10 (CoQH2, 250 mg/kg/day) for one week increased plasma CoQ10 concentrations, with an accompanying decrease in plasma CoQ9 concentrations.	ubiquinol	36-41	coenzyme Q9	Mus musculus	150-154
16866349-2	2006	E272 of the conserved cytochrome b PEWY motif has been suggested as a ligand and proton acceptor for ubiquinol oxidation at center P. We introduced the two replacement mutations, E272D and E272Q, into the mitochondrially encoded cytochrome b gene by biolistic transformation to study their effects on substrate binding and catalysis.	ubiquinol	101-110	mitochondrially encoded cytochrome b	Homo sapiens	22-34
16819881-4	2006	The mutant TRbeta(H435A) is nonresponsive to physiological concentrations of T3 but can be activated by the synthetic hormone analogue QH2 which potently activates His435-->Ala mutant at concentrations that do not activate the wild-type receptors TRalpha and TRbeta.	ubiquinol	135-138	T cell receptor beta locus	Homo sapiens	11-17
16819881-4	2006	The mutant TRbeta(H435A) is nonresponsive to physiological concentrations of T3 but can be activated by the synthetic hormone analogue QH2 which potently activates His435-->Ala mutant at concentrations that do not activate the wild-type receptors TRalpha and TRbeta.	ubiquinol	135-138	T cell receptor alpha locus	Homo sapiens	250-257
16819881-4	2006	The mutant TRbeta(H435A) is nonresponsive to physiological concentrations of T3 but can be activated by the synthetic hormone analogue QH2 which potently activates His435-->Ala mutant at concentrations that do not activate the wild-type receptors TRalpha and TRbeta.	ubiquinol	135-138	T cell receptor beta locus	Homo sapiens	262-268
16387461-10	2006	Thus, lifelong dietary supplementation with CoQH2 decreased the degree of senescence in middle-aged SAMP1 mice.	ubiquinol	44-49	transmembrane protein 201	Mus musculus	100-105
15833742-5	2005	We propose that electron transfer between cytochrome b subunits minimizes the formation of semiquinone-ferrocytochrome b(H) complexes at center N and favors ubiquinol oxidation at center P by increasing the amount of oxidized cytochrome b.	ubiquinol	157-166	cytochrome b	Saccharomyces cerevisiae S288C	42-54
16005845-3	2005	The bc1 oxidizes a ubiquinol molecule to ubiquinone by a unique "bifurcated" reaction where the two released electrons go to different acceptors: one is accepted by the mobile redox active domain of the [2Fe-2S] iron-sulfur Rieske protein (FeS protein) and the other goes to cytochrome b.	ubiquinol	19-28	mitochondrially encoded cytochrome b	Homo sapiens	275-287
16005845-8	2005	The rate-limiting step of ubiquinol oxidation is then the re-location of a ubiquinol molecule from its stand-by site within cytochrome b into a catalytic site, which is formed only transiently, after docking of the mobile redox domain of the FeS protein to cytochrome b.	ubiquinol	26-35	mitochondrially encoded cytochrome b	Homo sapiens	124-136
16005845-8	2005	The rate-limiting step of ubiquinol oxidation is then the re-location of a ubiquinol molecule from its stand-by site within cytochrome b into a catalytic site, which is formed only transiently, after docking of the mobile redox domain of the FeS protein to cytochrome b.	ubiquinol	26-35	mitochondrially encoded cytochrome b	Homo sapiens	257-269
16005845-8	2005	The rate-limiting step of ubiquinol oxidation is then the re-location of a ubiquinol molecule from its stand-by site within cytochrome b into a catalytic site, which is formed only transiently, after docking of the mobile redox domain of the FeS protein to cytochrome b.	ubiquinol	75-84	mitochondrially encoded cytochrome b	Homo sapiens	124-136
16005845-8	2005	The rate-limiting step of ubiquinol oxidation is then the re-location of a ubiquinol molecule from its stand-by site within cytochrome b into a catalytic site, which is formed only transiently, after docking of the mobile redox domain of the FeS protein to cytochrome b.	ubiquinol	75-84	mitochondrially encoded cytochrome b	Homo sapiens	257-269
15476858-4	2004	Secondly, the oxidoreductase maintains the endogenous lipid-soluble antioxidants, alpha-tocopherol-hydroquinone and ubiquinol in their reduced and active forms.	ubiquinol	116-125	thioredoxin reductase 1	Homo sapiens	14-28
15718226-0	2005	Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae.	ubiquinol	39-48	cytochrome b	Saccharomyces cerevisiae S288C	0-12
16873929-4	2005	However, when tNOX is inhibited and plasma membrane electron transport is diminished, both reduced coenzyme Q(10) (ubiquinol) and NADH would be expected to accumulate.	ubiquinol	115-124	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	14-18
14654068-5	2003	The defect in complex III is within the ubiquinol binding site of the cytochrome b subunit.	ubiquinol	40-49	mitochondrially encoded cytochrome b	Homo sapiens	70-82
14993791-11	2004	Without mitochondrial enzymes, BHA stimulated the ubiquinol-dependent reduction of cytochrome c (complex III), but it might have some detrimental effects on the mitochondrial enzyme reaction of complex III.	ubiquinol	50-59	cytochrome c, somatic	Homo sapiens	83-95
15051313-4	2004	A network of intramitochondrial antioxidants consisting of the enzymes Mn-superoxide dismutase and glutathione peroxidase and of the reductants NADH(2), ubiquinol and reduced glutathione, is operative in minimizing the potentially harmful effects of O(2)(-), NO, H(2)O(2) and ONOO(-).	ubiquinol	153-162	superoxide dismutase 2	Homo sapiens	71-94
14641050-12	2003	The site of single-electron deviation to dioxygen was found to be ubiquinol interacting with the Rieske iron-sulphur protein and low-potential cytochrome b of the bc (1) complex.	ubiquinol	66-75	mitochondrially encoded cytochrome b	Homo sapiens	143-155
12767232-8	2003	Together with the X-ray structures, these results suggest substrate ubiquinol binds in a fashion similar to that of stigmatellin with H-bonds between H161 of the Rieske iron-sulfur protein and E272 of the cyt b protein.	ubiquinol	68-77	cytochrome b	Saccharomyces cerevisiae S288C	205-210
16328826-1	2004	The recognition that, in photosynthesis, the plastoquinol oxidizing cytochrome b (6f ) complex resembles the ubiquinol oxidizing cytochrome bc1 complex in respiration is one of the examples of exciting universalization in biological research.	ubiquinol	109-118	mitochondrially encoded cytochrome b	Homo sapiens	68-80
12745255-2	2003	We describe a defect in the ubiquinol binding site (Q(O)) within cytochrome b in complex III only in the interfibrillar population of cardiac mitochondria during aging.	ubiquinol	28-37	cytochrome b, mitochondrial	Rattus norvegicus	65-77
16228609-4	2004	On the basis of X-ray crystallographic studies of cytochrome bc (1), it has been proposed that the Rieske iron-sulfur protein undergoes large conformational changes as it transports electrons from ubiquinol to cytochrome c (1).	ubiquinol	197-206	cytochrome c, somatic	Homo sapiens	210-222
16120348-3	2003	Decylubiquinone did not stimulate O2 consumption, but did initiate an SOD-sensitive cytochrome c reduction when complex I was isolated away from ubiquinol-cytochrome c oxidoreductase.	ubiquinol	145-154	LOC104968582	Bos taurus	84-96
12270134-4	2002	Ubiquinols inhibited the nSMase more efficiently than ubiquinones, and hydrophobic homologs with six or nine isoprene units were the most effective inhibitors.	ubiquinol	0-10	sphingomyelin phosphodiesterase 2	Homo sapiens	25-31
14695919-0	2003	Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase.	ubiquinol	32-41	dihydrolipoamide dehydrogenase	Homo sapiens	45-68
14695919-0	2003	Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase.	ubiquinol	32-41	peroxiredoxin 5	Homo sapiens	70-91
14695919-0	2003	Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase.	ubiquinol	32-41	glutathione-disulfide reductase	Homo sapiens	96-117
12270134-5	2002	Inhibition of nSMase by ubiquinols displayed similarities with inhibition by manumycin and the hydroquinones F11334"s, suggesting that these compounds could act as structural analogs of ubiquinol.	ubiquinol	24-34	sphingomyelin phosphodiesterase 2	Homo sapiens	14-20
12270134-5	2002	Inhibition of nSMase by ubiquinols displayed similarities with inhibition by manumycin and the hydroquinones F11334"s, suggesting that these compounds could act as structural analogs of ubiquinol.	ubiquinol	24-33	sphingomyelin phosphodiesterase 2	Homo sapiens	14-20
12101082-7	2002	Inhibition of the mitochondrion complex I nicotinamide adenine dinucleotide phosphate-dependent oxidase by diphenylene iodonium (DPI), which blocks the conversion of ubiquinone --> ubiquinol, abrogated IL-1 beta-dependent nuclear translocation and activation of HIF-1 alpha.	ubiquinol	184-193	interleukin 1 beta	Homo sapiens	205-214
12177505-1	2002	The plant mitochondrial electron transport chain is branched such that electrons at ubiquinol can be diverted to oxygen via the alternative oxidase (AOX).	ubiquinol	84-93	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	128-147
12177505-1	2002	The plant mitochondrial electron transport chain is branched such that electrons at ubiquinol can be diverted to oxygen via the alternative oxidase (AOX).	ubiquinol	84-93	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	149-152
12101082-7	2002	Inhibition of the mitochondrion complex I nicotinamide adenine dinucleotide phosphate-dependent oxidase by diphenylene iodonium (DPI), which blocks the conversion of ubiquinone --> ubiquinol, abrogated IL-1 beta-dependent nuclear translocation and activation of HIF-1 alpha.	ubiquinol	184-193	hypoxia inducible factor 1 subunit alpha	Homo sapiens	265-276
11967083-0	2002	Roles of NapF, NapG and NapH, subunits of the Escherichia coli periplasmic nitrate reductase, in ubiquinol oxidation.	ubiquinol	97-106	NSF attachment protein gamma	Homo sapiens	15-19
11967083-12	2002	The results clearly established that NapG and H, but not NapF, are essential for electron transfer from ubiquinol to NapAB.	ubiquinol	104-113	NSF attachment protein gamma	Homo sapiens	37-41
11967083-14	2002	We propose that NapG and H form an energy- conserving quinol dehydrogenase functioning as either components of a proton pump or in a Q cycle, as electrons are transferred from ubiquinol to NapC.	ubiquinol	176-185	NSF attachment protein gamma	Homo sapiens	16-20
11801238-1	2002	Plant mitochondria contain a non-protonmotive alternative oxidase (AOX) that couples the oxidation of ubiquinol to the complete reduction of oxygen to water.	ubiquinol	102-111	acyl-CoA oxidase 1	Homo sapiens	46-65
11801238-1	2002	Plant mitochondria contain a non-protonmotive alternative oxidase (AOX) that couples the oxidation of ubiquinol to the complete reduction of oxygen to water.	ubiquinol	102-111	acyl-CoA oxidase 1	Homo sapiens	67-70
11725867-2	2001	I would like to suggest that in brown fat of control mice, UCP1 is present in an amount higher than UCP2 and 3 and, therefore, is able to cause (a) some fatty acid-mediated decrease in proton motive force in resting state and, hence, (b) oxidation of CoQH2 to CoQ which is shown by Klingenberg and coworkers to be cofactor for UCPs.	ubiquinol	251-256	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	59-63
11697117-2	2001	When 5-25 U/ml SOD was added, QH2 showed a pronounced ability to inhibit ML oxidation.	ubiquinol	30-33	superoxide dismutase 1	Homo sapiens	15-18
11245784-7	2001	The alternative oxidase enables respiration to continue in the presence of inhibitors for ubiquinol:cytochrome c oxidoreductase and cytochrome c oxidase.	ubiquinol	90-99	cytochrome c, somatic	Homo sapiens	100-112
11152271-2	2000	An analysis of the steady-state kinetics of cytochrome c reduction by ubiquinol-0, after a light-induced steady-state electron flow had been attained, showed that the rate of this reaction is primarily controlled by the one-electron oxidation of the ubiquinol-anion.	ubiquinol	70-79	cytochrome c, somatic	Homo sapiens	44-56
11152271-3	2000	Re-reduction of the light-oxidized reaction center primary donor by cytochrome c was measured at different reduction levels of the ubiquinone-0/ubiquinol-0 pool.	ubiquinol	144-153	cytochrome c, somatic	Homo sapiens	68-80
11152271-5	2000	At low reduction levels of the ubiquinone-0/ubiquinol-0 pool, the total cytochrome c concentration had a major control over the rate of reduction of the primary donor.	ubiquinol	44-55	cytochrome c, somatic	Homo sapiens	72-84
10531315-4	1999	With cytochrome bc(1) complex from a yeast mutant that cannot synthesize ubiquinone, cytochrome b reduction by either menaquinol or ubiquinol was rapid and monophasic.	ubiquinol	132-141	cytochrome b	Saccharomyces cerevisiae S288C	5-17
10971589-7	2000	These results indicate that the length of the flexible linker region is critical for interaction of ubiquinol with the bc1 complex, consistent with electron transfer mechanisms in which ubiquinol must simultaneously interact with the iron-sulfur protein and cytochrome b.	ubiquinol	100-109	mitochondrially encoded cytochrome b	Homo sapiens	258-270
10971589-7	2000	These results indicate that the length of the flexible linker region is critical for interaction of ubiquinol with the bc1 complex, consistent with electron transfer mechanisms in which ubiquinol must simultaneously interact with the iron-sulfur protein and cytochrome b.	ubiquinol	186-195	mitochondrially encoded cytochrome b	Homo sapiens	258-270
9587406-0	1998	Dicyclohexylcarbodiimide inhibits proton pumping in ubiquinol:cytochrome c oxidoreductase of Rhodobacter sphaeroides and binds to aspartate-187 of cytochrome b.	ubiquinol	52-61	cytochrome b	Saccharomyces cerevisiae S288C	147-159
10591529-1	1999	The midpoint potential of the [2Fe-2S] cluster of the Rieske iron-sulfur protein (Em7 = +280 mV) is the primary determinant of the rate of electron transfer from ubiquinol to cytochrome c catalyzed by the cytochrome bc1 complex.	ubiquinol	162-171	cytochrome c, somatic	Homo sapiens	175-187
10354495-3	1999	However, in the absence of NADH, reduced coenzyme Q10 (Q10H2=ubiquinol) was oxidized at a rate of 15+/-6 nmol min-1 mg protein-1 depending on degree of purification.	ubiquinol	61-70	CD59 molecule (CD59 blood group)	Homo sapiens	110-115
10217438-3	1999	We demonstrated that lipoamide dehydrogenase can reduce ubiquinone to ubiquinol.	ubiquinol	70-79	dihydrolipoamide dehydrogenase	Homo sapiens	21-44
10072046-5	1999	Analysis of 70 different amino acid sequences of the ND6 subunit indicated that the 14484 mutation affects an amino acid belonging to its most conserved region, which shows local similarities with cytochrome b regions interacting with ubiquinone or ubiquinol in complex III.	ubiquinol	249-258	mitochondrially encoded NADH dehydrogenase 6	Homo sapiens	53-56
10072046-5	1999	Analysis of 70 different amino acid sequences of the ND6 subunit indicated that the 14484 mutation affects an amino acid belonging to its most conserved region, which shows local similarities with cytochrome b regions interacting with ubiquinone or ubiquinol in complex III.	ubiquinol	249-258	mitochondrially encoded cytochrome b	Homo sapiens	197-209
10072046-6	1999	Our results suggest that both 14484 and 14459 mutations may affect amino acids forming the interaction site of ubiquinol product, and the 14484 mutation produces a biochemical defect resembling in part that already reported for the common 11778/ND4 LHON mutation.	ubiquinol	111-120	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	245-248
9852050-9	1998	These results indicate that generation of O-2 during the oxidation of ubiquinol by the cytochrome bc1 complex results from a leakage of the second electron of ubiquinol from its Q cycle electron transfer pathway to interact with oxygen.	ubiquinol	70-79	immunoglobulin kappa variable 1D-39	Homo sapiens	42-45
9852050-9	1998	These results indicate that generation of O-2 during the oxidation of ubiquinol by the cytochrome bc1 complex results from a leakage of the second electron of ubiquinol from its Q cycle electron transfer pathway to interact with oxygen.	ubiquinol	159-168	immunoglobulin kappa variable 1D-39	Homo sapiens	42-45
9932648-0	1998	Exogenous ubiquinol analogues affect the fluorescence of NCD-4 bound to aspartate-160 of yeast cytochrome b.	ubiquinol	10-19	cytochrome b	Saccharomyces cerevisiae S288C	95-107
9585479-6	1998	In contrast, in vivo enrichment with the co-antioxidant CoQ10H2 decreased LDL lipid peroxidation induced by SIN-1.	ubiquinol	56-63	MAPK associated protein 1	Homo sapiens	108-113
9585479-11	1998	Exposure of human plasma to SIN-1 resulted in the loss of ascorbate followed by loss of CoQ10H2 and bilirubin.	ubiquinol	88-95	MAPK associated protein 1	Homo sapiens	28-33
9565029-2	1998	Cytochrome bc1 transfers electrons from ubiquinol to cytochrome c and uses the energy thus released to form an electrochemical gradient across the inner membrane.	ubiquinol	40-49	LOC104968582	Bos taurus	53-65
9554960-1	1998	The plant-type ubiquinol:oxygen oxidoreductase, commonly called the alternative oxidase, is a respiratory enzyme thought to contain non-heme iron at its active site.	ubiquinol	15-24	oxidoreductase	Arabidopsis thaliana	32-46
9497325-5	1998	Exposure of isolated HDL to either low fluxes of aqueous peroxyl radicals, Cu2+ ions, or soybean lipoxygenase resulted in the oxidation of apoAI and apoAII during the earliest stages of the reaction, i.e. after consumption of ubiquinol-10 and in the presence of alpha-TOH.	ubiquinol	226-235	linoleate 9S-lipoxygenase-4	Glycine max	97-109
9889976-11	1998	The electron acceptor for membrane glucose dehydrogenase is ubiquinone which is subsequently oxidized directly by ubiquinol oxidases or by electron transfer chains involving cytochrome bc1, cytochrome c and cytochrome c oxidases.	ubiquinol	114-123	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	35-56
9889976-11	1998	The electron acceptor for membrane glucose dehydrogenase is ubiquinone which is subsequently oxidized directly by ubiquinol oxidases or by electron transfer chains involving cytochrome bc1, cytochrome c and cytochrome c oxidases.	ubiquinol	114-123	cytochrome c, somatic	Homo sapiens	190-202
9889976-11	1998	The electron acceptor for membrane glucose dehydrogenase is ubiquinone which is subsequently oxidized directly by ubiquinol oxidases or by electron transfer chains involving cytochrome bc1, cytochrome c and cytochrome c oxidases.	ubiquinol	114-123	cytochrome c, somatic	Homo sapiens	207-219