PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2067134-0 1991 [Time courses of methemoglobin and urinary metabolites in two cases of acute poisoning by aromatic amines]. aromatic amines 90-105 hemoglobin subunit gamma 2 Homo sapiens 17-30 1848349-0 1991 Diethyldithiocarbamate suppresses the plant activation of aromatic amines into mutagens by inhibiting tobacco cell peroxidase. aromatic amines 58-73 peroxidase N1 Nicotiana tabacum 115-125 2385242-2 1990 In our studies of the metabolism of aromatic amines in the Ames/Salmonella assay, we observed a rapid and quantitative conversion of the mutagenic and carcinogenic aromatic amine 2,4-diaminotoluene (2,4-DAT) to a single product. aromatic amines 36-51 solute carrier family 6 member 3 Rattus norvegicus 203-206 1914494-5 1991 Isozymes of the UGT enzyme superfamily that control the glucuronidation of metabolites of aromatic hydrocarbons and of N-oxidized aromatic amines have been identified in rats and humans. aromatic amines 130-145 beta-1,3-glucuronyltransferase 2 Homo sapiens 16-19 2167182-0 1990 Competitive binding affinity of carcinogenic aromatic amines to the rat hepatic aromatic hydrocarbon (Ah) receptor in vitro and potency to induce monooxygenase activity in vivo. aromatic amines 45-60 aryl hydrocarbon receptor Rattus norvegicus 80-114 1912302-1 1991 The N-hydroxylation of representative aromatic amines by rabbit liver microsomes was mediated by cytochrome P-450 as demonstrated by the sensitivity to carbon monoxide and other cytochrome P-450 inhibitors. aromatic amines 38-53 cytochrome P-450 Oryctolagus cuniculus 97-113 1912302-1 1991 The N-hydroxylation of representative aromatic amines by rabbit liver microsomes was mediated by cytochrome P-450 as demonstrated by the sensitivity to carbon monoxide and other cytochrome P-450 inhibitors. aromatic amines 38-53 cytochrome P-450 Oryctolagus cuniculus 178-194 1913972-8 1991 Evidence is presented which supports a role for PHS in the bioactivation of several polycyclic aromatic hydrocarbons and aromatic amines, two classes of carcinogens which induce extrahepatic neoplasia. aromatic amines 121-136 pterin-4 alpha-carbinolamine dehydratase 1 Homo sapiens 48-51 2176974-0 1990 Binding of aromatic amines to the rat hepatic Ah receptor in vitro and in vivo and to the 8S and 4S estrogen receptor of rat uterus and rat liver. aromatic amines 11-26 aryl hydrocarbon receptor Rattus norvegicus 46-57 2176974-1 1990 Studies on structurally related aromatic amines with different carcinogenic properties have shown that 2-acetylaminofluorene (2-AAF) and 2-acetylaminophenanthrene (AAP) inhibit the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the Ah receptor in vitro. aromatic amines 32-47 aryl hydrocarbon receptor Rattus norvegicus 235-246 2176974-5 1990 Ornithine decarboxylase activity is induced by all aromatic amines tested irrespective of their Ah receptor affinity. aromatic amines 51-66 ornithine decarboxylase 1 Rattus norvegicus 0-23 2176974-8 1990 Our study demonstrates that structurally related aromatic amines in their unmetabolized form interact differentially with a cellular target protein, the Ah receptor, in vitro as well as in vivo. aromatic amines 49-64 aryl hydrocarbon receptor Rattus norvegicus 153-164 35341532-2 2022 In this regard, herein rapid, selective and highly efficient chromo-fluorogenic detection of ammonia/aliphatic amines over aromatic amines has been investigated by means of a novel "opto-electronic nose", CN-2, synthesized in a single-step via multiple inter/intramolecular C-N fusion reactions. aromatic amines 123-138 carnosine dipeptidase 2 Homo sapiens 205-209 1694720-2 1990 One pivotal gene, CYP1A1, codes for an inducible cytochrome P450 isozyme (P450IA1) responsible for the bioactivation of numerous carcinogenic polycyclic hydrocarbons and aromatic amines. aromatic amines 170-185 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 18-24 2079429-9 1990 Glucose and aromatic amines, as well as aromatic aldehydes and glucamine react to form deoxysorbitol derivates, which then have similar biokinetics after linkage to serum albumin. aromatic amines 12-27 albumin Homo sapiens 165-178 2134672-2 1990 The induction rate and total activity of this cytochrome P-450 isozyme were well correlated with sex, species, and target organ differences in hepatocarcinogenic susceptibility of animals to the aromatic amines. aromatic amines 195-210 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 46-62 35483145-0 2022 In Silico simulation of Cytochrome P450-Mediated metabolism of aromatic amines: A case study of N-Hydroxylation. aromatic amines 63-78 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-39 35522204-0 2022 Divergent Regioselective Csp2-H Difluoromethylation of Aromatic Amines Enabled by Nickel Catalysis. aromatic amines 55-70 regulator of calcineurin 2 Homo sapiens 25-29 3356064-0 1988 Hepatic cytochrome P-450 isozyme(s) induced by dietary carcinogenic aromatic amines preferentially in female mice of DBA/2 and other strains. aromatic amines 68-83 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 8-24 2670357-8 1989 Specific forms of cytochrome P-450 have been shown to be involved in the initial step in the activation (N-hydroxylation) of aromatic amines and amides. aromatic amines 125-140 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-34 2670357-14 1989 Polymorphisms in both cytochrome P-450 and N-acetyltransferase expression may be critical determinants in the susceptibility of individuals to the toxicity and carcinogenicity of aromatic amines and amides. aromatic amines 179-194 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 22-62 2495173-1 1989 Prostaglandin H synthase (PHS), an arachidonic acid-dependent peroxidase, has been implicated in the peroxidative activation of carcinogenic aromatic amines in extrahepatic carcinogen target tissues of experimental animals. aromatic amines 141-156 pterin-4 alpha-carbinolamine dehydratase 1 Homo sapiens 0-24 2495173-1 1989 Prostaglandin H synthase (PHS), an arachidonic acid-dependent peroxidase, has been implicated in the peroxidative activation of carcinogenic aromatic amines in extrahepatic carcinogen target tissues of experimental animals. aromatic amines 141-156 pterin-4 alpha-carbinolamine dehydratase 1 Homo sapiens 26-29 3356064-6 1988 These findings indicate that carcinogenic aromatic amines such as Trp P-1 and Trp P-2 are able to induce hepatic cytochrome P-450 isozyme(s) not only in Ah-responsive mice (BALB/c and CDF1) but also in Ah-nonresponsive DBA/2 mice and that the cytochrome P-450 induction is controlled by androgen(s). aromatic amines 42-57 polycystin 2, transient receptor potential cation channel Mus musculus 78-85 3356064-6 1988 These findings indicate that carcinogenic aromatic amines such as Trp P-1 and Trp P-2 are able to induce hepatic cytochrome P-450 isozyme(s) not only in Ah-responsive mice (BALB/c and CDF1) but also in Ah-nonresponsive DBA/2 mice and that the cytochrome P-450 induction is controlled by androgen(s). aromatic amines 42-57 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 113-129 3356064-6 1988 These findings indicate that carcinogenic aromatic amines such as Trp P-1 and Trp P-2 are able to induce hepatic cytochrome P-450 isozyme(s) not only in Ah-responsive mice (BALB/c and CDF1) but also in Ah-nonresponsive DBA/2 mice and that the cytochrome P-450 induction is controlled by androgen(s). aromatic amines 42-57 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 243-259 2964867-0 1987 Catalytic oxidation of 2-aminophenols and ortho hydroxylation of aromatic amines by tyrosinase. aromatic amines 65-80 tyrosinase Homo sapiens 84-94 3112063-3 1987 The results of unscheduled DNA synthesis assay with Ac2F cells using several carcinogenic aromatic amines (4-aminoazobenzene derivatives and amino acid pyrolysis products) suggested that this nuclear envelope-associated cytochrome P-450 activates a restricted portion of these aromatic amines, i.e., a tryptophan pyrolysis component and a glutamic acid pyrolysis component. aromatic amines 277-292 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 220-236 3112063-3 1987 The results of unscheduled DNA synthesis assay with Ac2F cells using several carcinogenic aromatic amines (4-aminoazobenzene derivatives and amino acid pyrolysis products) suggested that this nuclear envelope-associated cytochrome P-450 activates a restricted portion of these aromatic amines, i.e., a tryptophan pyrolysis component and a glutamic acid pyrolysis component. aromatic amines 90-105 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 220-236 3112063-4 1987 These results indicate that rat hepatocyte culture lines lack (or contain a reduced amount of) the cytoplasmic cytochrome P-450 but maintain a characteristic type of cytochrome P-450, probably a kind of cytochrome P-448H in their nuclear envelope, and this may be involved in oxidative metabolism of a restricted portion of aromatic amines. aromatic amines 324-339 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 166-182 4016737-6 1985 It is concluded that the (+)-catechin inhibits the mutagenicity of aromatic amines in the Ames test by interfering with their cytochrome P-450-dependent bioactivation and by direct interaction with the proximate carcinogen, but the former mechanism is unlikely to occur in vivo because the high doses of the flavonoid required are not achieved. aromatic amines 67-82 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 126-142 3843505-2 1985 SAR derived from a retrospective classification of a series of aromatic amines were used to study the estimation of carcinogenic risk by analogy. aromatic amines 63-78 sarcosine dehydrogenase Homo sapiens 0-3 3567888-0 1987 Induction of ornithine decarboxylase by aromatic amines in rat liver. aromatic amines 40-55 ornithine decarboxylase 1 Rattus norvegicus 13-36 3567888-2 1987 MC and all aromatic amines increased the ODC activity of rat liver from 3.6-fold (MC) to maximal 5.7-fold (AAS). aromatic amines 11-26 ornithine decarboxylase 1 Rattus norvegicus 41-44 6832094-7 1983 The present results indicate that different species of cytochrome P-450 are involved in the N-hydroxylation and mutagenic activation of aromatic amines. aromatic amines 136-151 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 55-71 4066048-2 1985 Internal stress of aromatic amines has so far been evaluated by their determination in blood or urine and by the degree of methemoglobin formation. aromatic amines 19-34 hemoglobin subunit gamma 2 Homo sapiens 123-136 6360828-0 1983 Mutagenicity of structurally related aromatic amines in the Salmonella/mammalian microsome test with various S-9 fractions. aromatic amines 37-52 ribosomal protein S9 Homo sapiens 109-112 6865923-0 1983 The relationship between increases in the hepatic content of cytochrome P-450, form 5, and in the metabolism of aromatic amines to mutagenic products following treatment of rabbits with phenobarbital. aromatic amines 112-127 cytochrome P-450 Oryctolagus cuniculus 61-85 6865923-4 1983 The results indicate that phenobarbital increases the hepatic microsomal concentration of cytochrome P-450, form 5, to the same extent that it increases form 5-mediated metabolism of aromatic amines to mutagenic products: 10- to 12-fold. aromatic amines 183-198 cytochrome P-450 Oryctolagus cuniculus 90-114 6438922-0 1984 Specificity of four forms of cytochrome P-450 in the metabolic activation of several aromatic amines and benzo[a]pyrene. aromatic amines 85-100 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 29-45 33609293-2 2021 NAT1 is important in the biotransformation of aromatic amines, an important example being p-phenylenediamine (PPD), a hair dye molecule. aromatic amines 46-61 N-acetyltransferase 1 Homo sapiens 0-4 6180607-4 1982 Extensive studies by Huggins and by others have shown that the quinone reductase in liver and some other tissues of rats is inducible by various polycyclic hydrocarbons and aromatic amines, as well as by certain azo dyes. aromatic amines 173-188 crystallin, zeta Mus musculus 63-80 666540-0 1978 [Reactions of N-alkoxycycliminium salts, VIII: reactions of N-methoxypyridinium salts with aromatic amines and sulfonamides. aromatic amines 91-106 cytochrome c oxidase subunit 8A Homo sapiens 41-45 183481-1 1976 Ceruloplasmin (ferroxidase) the blue Cu-protein of vertebrate plasma, possesses significant oxidase activity towards Fe(II) and numerous aromatic amines and phenols. aromatic amines 137-152 ceruloplasmin Homo sapiens 0-13 14223073-0 1964 ENTHALPY OF BINDING OF AROMATIC AMINES TO BOVINE SERUM ALBUMIN. aromatic amines 23-38 albumin Homo sapiens 49-62 32124162-4 2021 The results show that among the various synthesized compounds, strongest AChE inhibition was found for the compound containing aliphatic amine analogs, while in case of BuChE, aromatic amines showed better activity as compared to aliphatic amines. aromatic amines 176-191 butyrylcholinesterase Homo sapiens 169-174 6295661-0 1983 Specificity of rat liver cytochrome P-450 isozymes in the mutagenic activation of benzo[a]pyrene, aromatic amines and aflatoxin B1. aromatic amines 98-113 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 25-41 33949438-2 2021 To discuss this phenomenon, the effects of the reaction conditions on the yield ratio of 1,4-DHP and 1,2-DHP were studied by using aromatic amines, aromatic aldehydes and ethyl propiolate as raw materials. aromatic amines 131-146 dihydropyrimidinase Homo sapiens 105-108 32497306-2 2020 NAT2 has previously been classified as an arylamine N-acetyltransferase that mainly converts aromatic amines, hydroxylamines and hydrazines. aromatic amines 93-108 N-acetyltransferase 2 Homo sapiens 0-4 32801088-4 2020 The features appearing in the model against AChE enzyme suggest that a small ring size, higher number of -CH2- groups, higher number of secondary aromatic amines and higher number of aromatic ketone groups may contribute to the inhibitory activity. aromatic amines 146-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 32529657-1 2020 In the present study, a series of eleven novel 1,3-diaryltriazene-substituted sulfathiazole moieties (ST1-11) was synthesized by the reaction of diazonium salt of sulfathiazole with substituted aromatic amines and their chemical structures were characterized by Fourier transform infrared, 1 H-NMR (nuclear magnetic resonance), 13 C-NMR, and high-resolution mass spectroscopy methods. aromatic amines 194-209 syndecan binding protein Homo sapiens 102-108 33108147-0 2020 Resveratrol enhances apoptosis induced by the heterocyclic aromatic amines in p53-wt LoVo cells, but not in p53-deficient HaCaT cells. aromatic amines 59-74 tumor protein p53 Homo sapiens 78-81 32212405-2 2020 Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF 5 , the chlorination and iodination of classically inert C sp2 -H bonds of aromatic amines occurs. aromatic amines 209-224 regulator of calcineurin 2 Homo sapiens 191-196 32277289-9 2020 The prediction showed that biodegradation rather than absorption or volatilization was the main removal process of aromatic amines in aerobic STP. aromatic amines 115-130 thyroid hormone receptor interactor 10 Homo sapiens 142-145 31203411-1 2019 Occupational and tobacco exposure to aromatic amines (AAs) including 4-aminobiphenyl (4-ABP) and 2-naphthylamine (2-NA) are associated with bladder cancer (BC) risk. aromatic amines 37-52 auxin-binding protein T92 Nicotiana tabacum 88-91 31332782-1 2019 BACKGROUND: N-acetyltransferase 2 (NAT2) is a key enzyme involved in the phase II metabolism of aromatic amines and heterocyclic aromatic amines present in a wide range of xenobiotics. aromatic amines 96-111 N-acetyltransferase 2 Homo sapiens 12-33 31332782-1 2019 BACKGROUND: N-acetyltransferase 2 (NAT2) is a key enzyme involved in the phase II metabolism of aromatic amines and heterocyclic aromatic amines present in a wide range of xenobiotics. aromatic amines 96-111 N-acetyltransferase 2 Homo sapiens 35-39 31254350-1 2019 OBJECTIVE: N-Acetyltransferase 2 (NAT2) is a phase II xenobiotic-metabolizing enzyme participating in the detoxification of toxic arylamines and aromatic amines. aromatic amines 145-160 N-acetyltransferase 2 Homo sapiens 11-32 31254350-1 2019 OBJECTIVE: N-Acetyltransferase 2 (NAT2) is a phase II xenobiotic-metabolizing enzyme participating in the detoxification of toxic arylamines and aromatic amines. aromatic amines 145-160 N-acetyltransferase 2 Homo sapiens 34-38 31292670-2 2019 Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the N-acetylation of aromatic amines and NAT2 is subjected to a common genetic polymorphism in human populations separating individuals into rapid, intermediate, and slow acetylator phenotypes. aromatic amines 78-93 N-acetyltransferase 1 Homo sapiens 6-27 31292670-2 2019 Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the N-acetylation of aromatic amines and NAT2 is subjected to a common genetic polymorphism in human populations separating individuals into rapid, intermediate, and slow acetylator phenotypes. aromatic amines 78-93 N-acetyltransferase 1 Homo sapiens 29-33 31292670-2 2019 Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the N-acetylation of aromatic amines and NAT2 is subjected to a common genetic polymorphism in human populations separating individuals into rapid, intermediate, and slow acetylator phenotypes. aromatic amines 78-93 N-acetyltransferase 2 Homo sapiens 42-46 31292670-2 2019 Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the N-acetylation of aromatic amines and NAT2 is subjected to a common genetic polymorphism in human populations separating individuals into rapid, intermediate, and slow acetylator phenotypes. aromatic amines 78-93 N-acetyltransferase 2 Homo sapiens 98-102 30879115-4 2019 The correlation coefficients were 0.996 or greater for concentration of the aromatic amines ranging from 0.01 to 10 mug mL-1. aromatic amines 76-91 L1 cell adhesion molecule Mus musculus 120-124 30950278-3 2019 CYP1A1, one of the three isoforms of the CYP1 family, is widely believed to play an important role in the metabolism and activation of numerous procarcinogens, e.g., polyaromatic hydrocarbons (PAHs) or aromatic amines. aromatic amines 202-217 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 30404161-9 2018 The results from QSAR studies indicated topological charge indices, polarizability, ionization potential (IP), and number of primary aromatic amines are main contributors for MGMT inhibition of base analogs. aromatic amines 133-148 O-6-methylguanine-DNA methyltransferase Homo sapiens 175-179 28403014-6 2018 NAT2 slow genotype carriers had an OR of 3.59 (95% CI: 2.62-4.93) for BC when exposed to aromatic amines and an OR of 2.07 (95% CI: 1.36-3.15) when exposed to PAHs. aromatic amines 89-104 N-acetyltransferase 2 Homo sapiens 0-4 30249479-4 2018 With regard to the two aromatic amines tested, only 2-aminoanthracene showed a clear species preference, activated 3-fold more effectively by human than by rat CYP1A1. aromatic amines 23-38 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 160-166 28403014-8 2018 This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC. aromatic amines 142-157 glutathione S-transferase mu 1 Homo sapiens 85-90 28403014-8 2018 This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC. aromatic amines 142-157 glutathione S-transferase theta 1 Homo sapiens 92-97 28403014-8 2018 This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC. aromatic amines 142-157 N-acetyltransferase 2 Homo sapiens 99-103 28403014-8 2018 This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC. aromatic amines 142-157 sulfotransferase family 1A member 1 Homo sapiens 108-115 28837769-1 2017 Two aromatic amines (ferrostatin-1 and liproxstatin-1) were recently identified from high-throughput screening efforts to uncover potent inhibitors of ferroptosis, the necrotic-like cell death induced by inhibition of glutathione peroxidase 4 (GPX4), deletion of the corresponding gpx4 gene, or starvation of GPX4 of its reducing cosubstrate, glutathione (GSH). aromatic amines 4-19 glutathione peroxidase 4 Mus musculus 218-242 29505746-1 2018 N-acetyltransferase-2 (NAT2) and Glutathione S-transferases (GSTs) are phase-II xenobiotic metabolizing enzymes participating in detoxification of toxic arylamines, aromatic amines, hydrazines and reactive oxygen species (ROS), which are produced under oxidative and electrophile stresses. aromatic amines 165-180 N-acetyltransferase 2 Homo sapiens 0-21 29505746-1 2018 N-acetyltransferase-2 (NAT2) and Glutathione S-transferases (GSTs) are phase-II xenobiotic metabolizing enzymes participating in detoxification of toxic arylamines, aromatic amines, hydrazines and reactive oxygen species (ROS), which are produced under oxidative and electrophile stresses. aromatic amines 165-180 N-acetyltransferase 2 Homo sapiens 23-27 29505746-1 2018 N-acetyltransferase-2 (NAT2) and Glutathione S-transferases (GSTs) are phase-II xenobiotic metabolizing enzymes participating in detoxification of toxic arylamines, aromatic amines, hydrazines and reactive oxygen species (ROS), which are produced under oxidative and electrophile stresses. aromatic amines 165-180 glutathione S-transferase kappa 1 Homo sapiens 61-65 29061807-0 2017 Molecular Interactions of Carcinogenic Aromatic Amines, 4-Aminobiphenyl and 4,4"-Diaminobiphenyl, with Lactoperoxidase - Insight to Breast Cancer. aromatic amines 39-54 lactoperoxidase Homo sapiens 103-118 28837769-1 2017 Two aromatic amines (ferrostatin-1 and liproxstatin-1) were recently identified from high-throughput screening efforts to uncover potent inhibitors of ferroptosis, the necrotic-like cell death induced by inhibition of glutathione peroxidase 4 (GPX4), deletion of the corresponding gpx4 gene, or starvation of GPX4 of its reducing cosubstrate, glutathione (GSH). aromatic amines 4-19 glutathione peroxidase 4 Mus musculus 244-248 28837769-1 2017 Two aromatic amines (ferrostatin-1 and liproxstatin-1) were recently identified from high-throughput screening efforts to uncover potent inhibitors of ferroptosis, the necrotic-like cell death induced by inhibition of glutathione peroxidase 4 (GPX4), deletion of the corresponding gpx4 gene, or starvation of GPX4 of its reducing cosubstrate, glutathione (GSH). aromatic amines 4-19 glutathione peroxidase 4 Mus musculus 281-285 28837769-1 2017 Two aromatic amines (ferrostatin-1 and liproxstatin-1) were recently identified from high-throughput screening efforts to uncover potent inhibitors of ferroptosis, the necrotic-like cell death induced by inhibition of glutathione peroxidase 4 (GPX4), deletion of the corresponding gpx4 gene, or starvation of GPX4 of its reducing cosubstrate, glutathione (GSH). aromatic amines 4-19 glutathione peroxidase 4 Mus musculus 309-313 28287744-1 2017 A nickel-catalyzed protocol for the conversion of aryl and heteroaryl alcohol derivatives to primary and secondary aromatic amines via C(sp2)-O bond cleavage is described. aromatic amines 115-130 Sp2 transcription factor Homo sapiens 135-140 27436995-5 2016 RESULTS: At the non-toxic dosages, chemical compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics dose-dependently increased IL-8 reporter gene expression. aromatic amines 77-92 C-X-C motif chemokine ligand 8 Homo sapiens 187-191 28740730-5 2017 Aromatic amines, tryptamine, and tyramine activate interleukin-2 but inhibit lysozyme. aromatic amines 0-15 interleukin 15 Gallus gallus 51-64 28696839-6 2017 GSTM1 negative genotype occurred more frequently in cancer cases exposed to aromatic amines, carbolineum, and in painters and varnishers. aromatic amines 76-91 glutathione S-transferase mu 1 Homo sapiens 0-5 27436995-6 2016 Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production. aromatic amines 66-81 C-X-C motif chemokine ligand 8 Homo sapiens 194-198 27436995-6 2016 Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production. aromatic amines 66-81 C-X-C motif chemokine ligand 8 Homo sapiens 326-330 26665088-5 2015 Reflection spectroscopy highlights that the aromatic amines dissolved in the subphase are able to induce the syn-to-anti conformational switching in the bis-porphyrin derivative. aromatic amines 44-59 synemin Homo sapiens 109-112 27924717-2 2016 The aim of this study was to (1) examine the metabolic capacity of RT-4 human bladder papilloma cells and (2) investigate the influence of aromatic amines on the induction of cytochrome P-450 1A1 (CYP1A1) activity and their effects on benzo[a]pyrene (BaP)-induced CYP1A1 activities. aromatic amines 139-154 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 175-195 27924717-2 2016 The aim of this study was to (1) examine the metabolic capacity of RT-4 human bladder papilloma cells and (2) investigate the influence of aromatic amines on the induction of cytochrome P-450 1A1 (CYP1A1) activity and their effects on benzo[a]pyrene (BaP)-induced CYP1A1 activities. aromatic amines 139-154 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 197-203 27924717-9 2016 Our results suggest that RT-4 cells represent a reliable model cell line to study arylamine- and PAH-induced effects in vitro and that BaP-induced CYP1A1 activities are modulated by aromatic amines. aromatic amines 182-197 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 147-153 26681036-1 2015 The incidence of bladder cancer is closely associated with exposure to aromatic amines, that can cause cancer only after metabolic activation regulated by N-acetyl transferase 1 and 2 (NAT1 and NAT2). aromatic amines 71-86 N-acetyltransferase 1 Homo sapiens 155-183 26681036-1 2015 The incidence of bladder cancer is closely associated with exposure to aromatic amines, that can cause cancer only after metabolic activation regulated by N-acetyl transferase 1 and 2 (NAT1 and NAT2). aromatic amines 71-86 N-acetyltransferase 1 Homo sapiens 185-189 26681036-1 2015 The incidence of bladder cancer is closely associated with exposure to aromatic amines, that can cause cancer only after metabolic activation regulated by N-acetyl transferase 1 and 2 (NAT1 and NAT2). aromatic amines 71-86 N-acetyltransferase 2 Homo sapiens 194-198 27356282-0 2016 Co(II) PCP Pincer Complexes as Catalysts for the Alkylation of Aromatic Amines with Primary Alcohols. aromatic amines 63-78 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-6 27213988-1 2016 Pd-catalyzed regioselective coupling of beta-C(sp(2))-H bonds in aromatic amines protected by oxalyl amide with carbon monoxide is reported. aromatic amines 65-80 colony stimulating factor 2 receptor subunit beta Homo sapiens 40-46 24410629-0 2014 Theoretical studies of the mechanism of N-hydroxylation of primary aromatic amines by cytochrome P450 1A2: radicaloid or anionic? aromatic amines 67-82 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 86-105 25588806-8 2015 Moreover, multiple carbon metabolites including amino acids, organic acids, sugars, sugar alcohols, and aromatic amines were also positively regulated by AtPED2. aromatic amines 104-119 peroxin 14 Arabidopsis thaliana 154-160 25103078-2 2014 Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. aromatic amines 180-195 glutathione S-transferase omega 1 Homo sapiens 0-33 25103078-2 2014 Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. aromatic amines 180-195 glutathione S-transferase omega 1 Homo sapiens 35-40 25103078-2 2014 Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. aromatic amines 180-195 sulfotransferase family 1A member 1 Homo sapiens 46-66 25103078-2 2014 Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. aromatic amines 180-195 sulfotransferase family 1A member 1 Homo sapiens 68-75 25010511-1 2014 Stereoselective palladium-catalyzed oxidative C-N bond coupling reactions between aromatic amines and alkenes involving a solvent-controlled regioselective bromination process under 1 atm of oxygen atmosphere are disclosed, providing easy access to two different brominated enamines. aromatic amines 82-97 ATM serine/threonine kinase Homo sapiens 184-187 24791559-4 2014 The NAT2 genotype may modify the risk of cancer by activating or detoxifying heterocyclic and aromatic amines. aromatic amines 94-109 N-acetyltransferase 2 Homo sapiens 4-8 24350727-11 2015 Myeloperoxidase is also known to be able to oxidize aromatic amines to reactive metabolites, and these observations suggest that metabolism outside of the liver may be important for the mechanism of aromatic amine-induced IDRs. aromatic amines 52-67 myeloperoxidase Rattus norvegicus 0-15 24928356-1 2014 N-acetyltransferase (NAT2) is a phase-II xenobiotic-metabolizing enzyme participating in the detoxification of toxic arylamines, aromatic amines and hydrazines. aromatic amines 129-144 N-acetyltransferase 2 Homo sapiens 21-25 24410629-3 2014 Energy profiles of the NH bond activation steps of two possible mechanisms of N-hydroxylation of a number of aromatic amines by CYP1A2, radicaloid and anionic, are studied by dispersion-corrected DFT calculations. aromatic amines 109-124 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 128-134 24410629-12 2014 Taken together, results suggest that the N-hydroxylation of aromatic amines in CYP1A2 undergoes the anionic mechanism. aromatic amines 60-75 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 79-85 24381021-0 2014 Application of C18-functional magnetic nanoparticles for extraction of aromatic amines from human urine. aromatic amines 71-86 Bardet-Biedl syndrome 9 Homo sapiens 15-18 24381021-1 2014 In this paper, a novel method using C18-functional ultrafine magnetic silica nanoparticles (C18-UMS NPs) as adsorbents was developed for rapid extraction and enrichment of aromatic amines from urine. aromatic amines 172-187 Bardet-Biedl syndrome 9 Homo sapiens 36-39 24381021-1 2014 In this paper, a novel method using C18-functional ultrafine magnetic silica nanoparticles (C18-UMS NPs) as adsorbents was developed for rapid extraction and enrichment of aromatic amines from urine. aromatic amines 172-187 Bardet-Biedl syndrome 9 Homo sapiens 92-95 24381021-3 2014 The aromatic amines can be adsorbed on C18-UMS NPs and isolated easily from the matrix with an external magnetic field. aromatic amines 4-19 Bardet-Biedl syndrome 9 Homo sapiens 39-42 22994574-7 2012 The urothelial cell systems may thus be useful as a tool for further studies on the N-acetylation of aromatic amines via NAT1. aromatic amines 101-116 N-acetyltransferase 1 Homo sapiens 121-125 24275315-7 2014 Here we observed a clear shift of dose-response curves towards decreased genotoxicity of the parent aromatic amines in the NAT-proficient cells. aromatic amines 100-115 arylamine N-acetyltransferase 2 Cricetulus griseus 123-126 23979979-1 2014 Myeloperoxidase (MPO) is a phase I enzyme playing a crucial role in metabolically activating a wide range of procarcinogens, such as polycyclic aromatic hydrocarbons and aromatic amines. aromatic amines 170-185 myeloperoxidase Homo sapiens 0-15 23979979-1 2014 Myeloperoxidase (MPO) is a phase I enzyme playing a crucial role in metabolically activating a wide range of procarcinogens, such as polycyclic aromatic hydrocarbons and aromatic amines. aromatic amines 170-185 myeloperoxidase Homo sapiens 17-20 23055191-1 2013 Microsomal epoxide hydrolase 1 (EPHX1) plays an important role in both the activation and the detoxification of polycyclic aromatic hydrocarbons and aromatic amines. aromatic amines 149-164 epoxide hydrolase 1 Homo sapiens 32-37 24595082-1 2013 N-acetyltransferase 2 (NAT2) gene encodes a phase II enzyme taking part in detoxification of aromatic amines. aromatic amines 93-108 N-acetyltransferase 2 Homo sapiens 23-27 23205911-0 2012 Tuning of ferromagnetic spin interactions in polymeric aromatic amines via modification of their pi-conjugated system. aromatic amines 55-70 spindlin 1 Homo sapiens 24-28 22859067-5 2012 The (CuI)(2)(Pip) complexes act as sensor materials, undergoing irreversible reaction with aliphatic and aromatic amines (Nu) in the vapour state, irreversibly producing cubanes (CuI)(4)Nu(4), with corresponding production of long wavelength emission. aromatic amines 105-120 prolactin induced protein Homo sapiens 13-16 22228101-2 2012 The UGT1A cluster encodes a family of UDP-glucuronosyltransferases (UGTs), which facilitate cellular detoxification and removal of aromatic amines. aromatic amines 131-146 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 4-9 24595082-1 2013 N-acetyltransferase 2 (NAT2) gene encodes a phase II enzyme taking part in detoxification of aromatic amines. aromatic amines 93-108 N-acetyltransferase 2 Homo sapiens 0-21 22751261-1 2012 The room temperature ionic liquid (IL) 1-butyl-3-methylimidazolium bis-(trifluorometanesulfonyl)imide BMIm[NTf2] was used as a novel medium for improvement of separation and quantization of 16 aromatic amines typically present as contaminants in consumer products and detected by HPLC coupled to an electrochemical detector. aromatic amines 193-208 nuclear transport factor 2 Homo sapiens 107-111 22092501-2 2012 Polymorphisms at N-acetyltransferase 2 locus, coding for an enzyme catalyzing acetylation of aromatic amines, might cause DNA adduct formation because of improper acetylation of these polyaromatic hydrocarbons. aromatic amines 93-108 N-acetyltransferase 2 Homo sapiens 17-38 21894985-0 2011 Explanation for main features of structure-genotoxicity relationships of aromatic amines by theoretical studies of their activation pathways in CYP1A2. aromatic amines 73-88 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 144-150 21541720-1 2011 Dopa decarboxylase (DDC or AADC) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the decarboxylation of L-aromatic amino acids into the corresponding aromatic amines. aromatic amines 168-183 dopa decarboxylase Homo sapiens 0-18 21541720-1 2011 Dopa decarboxylase (DDC or AADC) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the decarboxylation of L-aromatic amino acids into the corresponding aromatic amines. aromatic amines 168-183 dopa decarboxylase Homo sapiens 27-31 21541720-1 2011 Dopa decarboxylase (DDC or AADC) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the decarboxylation of L-aromatic amino acids into the corresponding aromatic amines. aromatic amines 168-183 pyridoxal phosphatase Homo sapiens 62-65 21880425-0 2011 Post-treatment of anaerobically degraded azo dye Acid Red 18 using aerobic moving bed biofilm process: enhanced removal of aromatic amines. aromatic amines 123-138 solute carrier family 35 member G1 Homo sapiens 0-4 20568013-1 2011 N-acetyltransferase 2 (NAT2) is phase II enzyme with major roles in catalyzing the detoxification of aromatic amines, which are known risk factors for bladder cancer, and are ubiquitously present in the environment. aromatic amines 101-116 N-acetyltransferase 2 Homo sapiens 0-21 21452828-9 2011 The nitration of aromatic amines by the photofragmentation products of RDX and PETN is presented as a unique, highly selective detection mechanism for nitroester- and nitramine-containing explosives and DHAs are presented as inexpensive and impermanent fluorogenic indicators for the selective, standoff/remote identification of RDX and PETN. aromatic amines 17-32 radixin Homo sapiens 329-332 21452828-9 2011 The nitration of aromatic amines by the photofragmentation products of RDX and PETN is presented as a unique, highly selective detection mechanism for nitroester- and nitramine-containing explosives and DHAs are presented as inexpensive and impermanent fluorogenic indicators for the selective, standoff/remote identification of RDX and PETN. aromatic amines 17-32 radixin Homo sapiens 71-74 20568013-1 2011 N-acetyltransferase 2 (NAT2) is phase II enzyme with major roles in catalyzing the detoxification of aromatic amines, which are known risk factors for bladder cancer, and are ubiquitously present in the environment. aromatic amines 101-116 N-acetyltransferase 2 Homo sapiens 23-27 21461569-1 2011 Myeloperoxidase (MPO) is a phase I enzyme that can bioactivate many specific procarcinogens, including polycyclic aromatic hydrocarbons and aromatic amines. aromatic amines 140-155 myeloperoxidase Homo sapiens 0-15 21461569-1 2011 Myeloperoxidase (MPO) is a phase I enzyme that can bioactivate many specific procarcinogens, including polycyclic aromatic hydrocarbons and aromatic amines. aromatic amines 140-155 myeloperoxidase Homo sapiens 17-20 20591428-5 2010 Our data suggest that exposure to mercury may affect the biotransformation of aromatic amines by NAT1. aromatic amines 78-93 N-acetyltransferase 1 Homo sapiens 97-101 20376575-4 2010 The rapid decolorization observed in batch culture, joined to a delay of about 24 h in COD removal and cell growth, suggests that enzymes involved in biodegradation of the aromatic amines generated after AO7 azo-bond cleavage (1-amino-2-naphthol [1-A2N] and 4-aminobenzenesulfonic acid [4-ABS]), are inducible in this microbial consortium. aromatic amines 172-187 ring finger protein 25 Homo sapiens 204-207 24278521-0 2010 Bioactivation of Aromatic Amines by Human CYP2W1, An Orphan Cytochrome P450 Enzyme. aromatic amines 17-32 cytochrome P450 family 2 subfamily W member 1 Homo sapiens 42-48 24278521-0 2010 Bioactivation of Aromatic Amines by Human CYP2W1, An Orphan Cytochrome P450 Enzyme. aromatic amines 17-32 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 60-75 19860458-1 2009 A series of mono- and disubstituted complexes, FeI(2)(CO)(x)L(4-x), x = 2 or 3, is conveniently accessed from simple mixing of N-heterocyclic carbenes, phosphines, and aromatic amines with FeI(2)(CO)(4), first reported by Hieber in 1928. aromatic amines 168-183 xenotropic and polytropic retrovirus receptor 1 Homo sapiens 68-78 20199096-3 2010 Because the concentration of drug required to produce a maximum signal for MPO protein free radical (MPO*) detection was different for each drug, this prompted us to consider that other aromatic amines may also show varying degrees of ability to induce MPO* formation. aromatic amines 186-201 myeloperoxidase Homo sapiens 75-78 20199096-3 2010 Because the concentration of drug required to produce a maximum signal for MPO protein free radical (MPO*) detection was different for each drug, this prompted us to consider that other aromatic amines may also show varying degrees of ability to induce MPO* formation. aromatic amines 186-201 myeloperoxidase Homo sapiens 101-104 20199096-3 2010 Because the concentration of drug required to produce a maximum signal for MPO protein free radical (MPO*) detection was different for each drug, this prompted us to consider that other aromatic amines may also show varying degrees of ability to induce MPO* formation. aromatic amines 186-201 myeloperoxidase Homo sapiens 101-104 20199096-4 2010 Immunoassay experiments using the immuno-spin-trapping technique were performed, which evaluated the potency of different aromatic amines containing the aniline substructure to generate the MPO*. aromatic amines 122-137 myeloperoxidase Homo sapiens 190-194 19961320-1 2010 Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of clinical drugs (e.g., clozapine, tacrine, tizanidine, and theophylline; n > 110), a number of procarcinogens (e.g., benzo[a]pyrene and aromatic amines), and several important endogenous compounds (e.g., steroids). aromatic amines 219-234 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 6-12 19248797-4 2009 We show here that functional human NAT1 or its murine counterpart Nat2 are present in different lung epithelial cells i.e. Clara cells, type II alveolar cells and bronchial epithelial cells, thus indicating that inhaled aromatic amines may undergo NAT-dependent biotransformation in lung epithelium. aromatic amines 220-235 N-acetyltransferase 1 Homo sapiens 35-39 19248797-4 2009 We show here that functional human NAT1 or its murine counterpart Nat2 are present in different lung epithelial cells i.e. Clara cells, type II alveolar cells and bronchial epithelial cells, thus indicating that inhaled aromatic amines may undergo NAT-dependent biotransformation in lung epithelium. aromatic amines 220-235 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 66-70 19248797-5 2009 Exposure of these cells to pathophysiologically relevant amounts of oxidants known to contribute to lung dysfunction, such as H(2)O(2) or peroxynitrite, was found to impair the NAT1/Nat2-dependent cellular biotransformation of aromatic amines. aromatic amines 227-242 N-acetyltransferase 1 Homo sapiens 177-181 19248797-5 2009 Exposure of these cells to pathophysiologically relevant amounts of oxidants known to contribute to lung dysfunction, such as H(2)O(2) or peroxynitrite, was found to impair the NAT1/Nat2-dependent cellular biotransformation of aromatic amines. aromatic amines 227-242 N-acetyltransferase 2 Homo sapiens 182-186 18989657-0 2008 Synergism of aromatic amines and benzo[a]pyrene in induction of Ah receptor-dependent genes. aromatic amines 13-28 aryl hydrocarbon receptor Homo sapiens 64-75 18989657-3 2008 In the present study, we analysed possible interactions between the aromatic amines 4-aminobiphenyl (4-ABP) as well as 2-naphthylamine (2-NA) and the polycyclic aromatic hydrocarbon benzo[a]pyrene (B[a]P). aromatic amines 68-83 amine oxidase copper containing 1 Homo sapiens 103-106 18989657-8 2008 Our results demonstrate that some aromatic amines may enhance the influence of B[a]P on Ah receptor-dependent genes. aromatic amines 34-49 aryl hydrocarbon receptor Homo sapiens 88-99 16844322-1 2006 BACKGROUND: Myeloperoxidase (MPO) contributes to pulmonary carcinogenesis through activation of a wide range of tobacco smoke procarcinogens, including benzo[a]pyrene and aromatic amines. aromatic amines 171-186 myeloperoxidase Homo sapiens 12-27 19018723-1 2008 The arylamine N-acetyltransferase (NAT) genes encode enzymes that catalyze the N-acetylation of aromatic amines and hydrazines and the O-acetylation of heterocyclic amines. aromatic amines 96-111 bromodomain containing 2 Homo sapiens 35-38 18680474-7 2008 Arylamine N acetyltransferases (NAT) convert aromatic amines or hydrazines to aromatic amides and hydrazides. aromatic amines 45-60 bromodomain containing 2 Homo sapiens 10-30 18680474-7 2008 Arylamine N acetyltransferases (NAT) convert aromatic amines or hydrazines to aromatic amides and hydrazides. aromatic amines 45-60 bromodomain containing 2 Homo sapiens 32-35 18355079-2 2008 TFA was discovered to be an efficient catalyst in the reactions with aromatic amines, whereas TiCl4 was found to be superior in the case of aliphatic amines. aromatic amines 69-84 coagulation factor III, tissue factor Homo sapiens 0-3 18264986-1 2008 2-(2-phenyl-1H-phenanthro-[9,10-d]imidazole-1-yl)-acetic acid (PPIA) and 2-(9-acridone)-acetic acid (AAA), two novel precolumn fluorescent derivatization reagents, have been developed and compared for analysis of primary aromatic amines by high performance liquid chromatographic fluorescence detection coupled with online mass spectrometric identification. aromatic amines 221-236 peptidylprolyl isomerase A Homo sapiens 63-67 18264986-2 2008 PPIA and AAA react rapidly and smoothly with the aromatic amines on the basis of a condensation reaction using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) as dehydrating catalyst to form stable derivatives with emission wavelengths at 380 and 440 nm, respectively. aromatic amines 49-64 peptidylprolyl isomerase A Homo sapiens 0-4 18264986-4 2008 With the better PPIA method, chromatographic separation of derivatized aromatic amines exhibited a good baseline resolution on an RP column. aromatic amines 71-86 peptidylprolyl isomerase A Homo sapiens 16-20 18264986-6 2008 The linear range is 24.41 fmol-200.0 pmol with correlation coefficients in the range of 0.9996-0.9999, and detection limits of PPIA-labeled aromatic amines are 0.12-0.21 nmol/L (S/N = 3). aromatic amines 140-155 peptidylprolyl isomerase A Homo sapiens 127-131 17936011-0 2007 New insights in the formation of deoxynucleoside adducts with the heterocyclic aromatic amines PhIP and IQ by means of ion trap MSn and accurate mass measurement of fragment ions. aromatic amines 79-94 moesin Homo sapiens 128-131 16405939-2 2006 Hemoglobin (Hb) adducts of 3-aminobiphenyl (3-ABP) and 4-aminobiphenyl (4-ABP) have been used as biomarkers of exposure to aromatic amines from cigarette smoke. aromatic amines 123-138 amine oxidase copper containing 1 Homo sapiens 46-49 16405939-2 2006 Hemoglobin (Hb) adducts of 3-aminobiphenyl (3-ABP) and 4-aminobiphenyl (4-ABP) have been used as biomarkers of exposure to aromatic amines from cigarette smoke. aromatic amines 123-138 amine oxidase copper containing 1 Homo sapiens 74-77 19568886-4 2008 Here, we have reviewed various aspects of CYPs for biomonitoring environmental health in terms of the CYP substrates, such as PAHs, aromatic amines, benzene/toluene, and tobacco smoking-related nitrosamines. aromatic amines 132-147 peptidylprolyl isomerase G Homo sapiens 42-45 18569592-3 2008 Research was thus conducted to define the role of GSTP1 genotypes in Caucasian bladder cancer cases with an occupational history of exposure to aromatic amines. aromatic amines 144-159 glutathione S-transferase pi 1 Homo sapiens 50-55 17542636-11 2007 The mutagenicity of aromatic amines (AAs) and HCAs, measured as the log of histidine revertants per nanomole of amine, log m, in Salmonella typhimurium TA 98 and TA 100 correlates with log(k(az)/k(s)) for a wide variety of carbocyclic and heterocyclic amine mutagens including PhIP. aromatic amines 20-35 pleckstrin homology domain interacting protein Homo sapiens 277-281 17376430-7 2007 These compounds are tertiary aromatic amines, non-competitive with ATP and possess high affinity towards the IGF-1 receptor. aromatic amines 29-44 insulin like growth factor 1 Homo sapiens 109-114 17311719-0 2007 Increasing selectivity for TNT-based explosive detection by synchronous luminescence and derivative spectroscopy with quantum yields of selected aromatic amines. aromatic amines 145-160 chromosome 16 open reading frame 82 Homo sapiens 27-30 16782969-3 2006 Gluthatione S-transferase alpha1 (GSTA1) may also be active in the metabolism of caffeine as it conjugates glutathione to aromatic amines. aromatic amines 122-137 glutathione S-transferase alpha 1 Homo sapiens 0-32 16782969-3 2006 Gluthatione S-transferase alpha1 (GSTA1) may also be active in the metabolism of caffeine as it conjugates glutathione to aromatic amines. aromatic amines 122-137 glutathione S-transferase alpha 1 Homo sapiens 34-39 16844322-1 2006 BACKGROUND: Myeloperoxidase (MPO) contributes to pulmonary carcinogenesis through activation of a wide range of tobacco smoke procarcinogens, including benzo[a]pyrene and aromatic amines. aromatic amines 171-186 myeloperoxidase Homo sapiens 29-32 16877261-3 2006 CYP4B1 also participates in the metabolism of certain xenobiotics that are protoxic, including valproic acid, 3-methylindole, 4-ipomeanol, 3-methoxy-4-aminoazobenzene, and numerous aromatic amines. aromatic amines 181-196 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 0-6 15450435-9 2004 The specific NAT1 inhibitor 5-iodosalicylic acid inhibited umuC gene expression induced by aromatic amines used. aromatic amines 91-106 N-acetyltransferase 1 Homo sapiens 13-17 16372832-0 2005 Heterologous co-expression of human cytochrome P450 1A2 and polymorphic forms of N-acetyltransferase 2 for studies on aromatic amines in V79 Chinese hamster cells. aromatic amines 118-133 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 36-55 16372832-0 2005 Heterologous co-expression of human cytochrome P450 1A2 and polymorphic forms of N-acetyltransferase 2 for studies on aromatic amines in V79 Chinese hamster cells. aromatic amines 118-133 N-acetyltransferase 2 Homo sapiens 81-102 16399348-3 2005 While the localization of SULT1A2 is poorly understood, it has been shown to metabolize a number of aromatic amines. aromatic amines 100-115 sulfotransferase family 1A member 2 Homo sapiens 26-33 15996806-10 2005 These data, based on various endpoints, show a midly genotoxic effect of 2,4-DAT in the HepG2 cells and confirm that this cell line is a suitable model to study the toxic effects of aromatic amines. aromatic amines 182-197 solute carrier family 6 member 3 Homo sapiens 77-80 16201373-1 2005 In the presence of a carbodiimine, i.e. DCC, a series of organoimido derivatives of polyoxometalates have been synthesized via the reaction of [alpha-Mo8O26]4- with aromatic amines and its hydrochloride salt. aromatic amines 165-180 DCC netrin 1 receptor Homo sapiens 40-43 15843388-0 2005 Escherichia coli BTC, a human cytochrome P450 competent tester strain with a high sensitivity towards alkylating agents: involvement of alkyltransferases in the repair of DNA damage induced by aromatic amines. aromatic amines 193-208 betacellulin Homo sapiens 17-20 15843388-0 2005 Escherichia coli BTC, a human cytochrome P450 competent tester strain with a high sensitivity towards alkylating agents: involvement of alkyltransferases in the repair of DNA damage induced by aromatic amines. aromatic amines 193-208 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 30-45 16041393-1 2005 Therapeutic and environmental aromatic amines and hydrazines are substrates for the arylamine N-acetyltransferases (NAT). aromatic amines 30-45 bromodomain containing 2 Mus musculus 94-114 16041393-1 2005 Therapeutic and environmental aromatic amines and hydrazines are substrates for the arylamine N-acetyltransferases (NAT). aromatic amines 30-45 bromodomain containing 2 Mus musculus 116-119 15450435-10 2004 These results could provide evidence that the bladder carcinogenic aromatic amines are mainly activated by the NAT1 enzyme to produce DNA damage rather than NAT2. aromatic amines 67-82 N-acetyltransferase 1 Homo sapiens 111-115 15450435-10 2004 These results could provide evidence that the bladder carcinogenic aromatic amines are mainly activated by the NAT1 enzyme to produce DNA damage rather than NAT2. aromatic amines 67-82 N-acetyltransferase 2 Homo sapiens 157-161 15584438-2 2004 Genetic polymorphisms which influence biomarkers (urinary metabolites, protein and DNA adducts), include P450 cytochromes (CYPs) and glutathione S-transferases (GSTs) in exposure to polycyclic aromatic hydrocarbons (PAHs), and acetyltransferases (NATs) in exposure to aromatic amines (AAs). aromatic amines 268-283 glutathione S-transferase mu 1 Homo sapiens 161-165 14582238-4 2003 Genetic polymorphisms that influence human genotoxic risk are those of glutathione s-transferase and cytochrome P450 in exposure to polycyclic aromatic hydrocarbons (PAHs), those of N-acetyltransferase in both occupational and environmental exposures to aromatic amines (AAs) and similar compounds. aromatic amines 254-269 glutathione S-transferase kappa 1 Homo sapiens 71-96 15028720-2 2004 The CYP1 enzymes are responsible for both metabolically activating and detoxifying numerous polycyclic aromatic hydrocarbons (PAHs) and aromatic amines present in combustion products. aromatic amines 136-151 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 14722254-1 2004 Acetyl CoA:arylamine N-acetyltransferase (NAT) enzymes catalyze the N-acetylation of aromatic amines and the O-acetylation of aryl hydroxylamines, reactions that govern the disposition and toxicity of many drugs and carcinogens. aromatic amines 85-100 bromodomain containing 2 Homo sapiens 42-45 12878219-1 2003 Human arylamine N-acetyltransferase 1 (NAT1) is a polymorphic phase II xenobiotic-metabolizing enzyme which catalyzes the biotransformation of primary aromatic amines, hydrazine drugs, and carcinogens. aromatic amines 151-166 N-acetyltransferase 1 Homo sapiens 6-37 12878219-1 2003 Human arylamine N-acetyltransferase 1 (NAT1) is a polymorphic phase II xenobiotic-metabolizing enzyme which catalyzes the biotransformation of primary aromatic amines, hydrazine drugs, and carcinogens. aromatic amines 151-166 N-acetyltransferase 1 Homo sapiens 39-43 15279838-1 2004 We newly developed 10 Salmonela typhimurium TA1538 strains each co-expressing a form of human cytochrome P450s (P450 or CYP) together with NADPH-cytochrome P450 reductase (CPR) for highly sensitive detection of mutagenic activation of mycotoxins, polycyclic aromatic hydrocarbons, heterocyclic amines, and aromatic amines at low substrate concentrations. aromatic amines 306-321 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 94-123 15197537-1 2004 N-acetyltransferase 1 (NAT1) modifies bladder cancer risk in European populations exposed to aromatic amines in cigarette smoke. aromatic amines 93-108 N-acetyltransferase 1 Homo sapiens 0-21 15197537-1 2004 N-acetyltransferase 1 (NAT1) modifies bladder cancer risk in European populations exposed to aromatic amines in cigarette smoke. aromatic amines 93-108 N-acetyltransferase 1 Homo sapiens 23-27 15122594-3 2004 Two N-acetyltransferase isozymes, NAT2 and NAT1, have major roles in catalyzing the N-acetylation and O-acetylation of aromatic amines. aromatic amines 119-134 N-acetyltransferase 2 Homo sapiens 34-38 15122594-3 2004 Two N-acetyltransferase isozymes, NAT2 and NAT1, have major roles in catalyzing the N-acetylation and O-acetylation of aromatic amines. aromatic amines 119-134 N-acetyltransferase 1 Homo sapiens 43-47 15122594-4 2004 Cytochrome p450 1B1 (CYP1B1) and sulfotransferase 1A1 (SULT1A1) are also involved in the metabolism of PAHs and aromatic amines. aromatic amines 112-127 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 15122594-4 2004 Cytochrome p450 1B1 (CYP1B1) and sulfotransferase 1A1 (SULT1A1) are also involved in the metabolism of PAHs and aromatic amines. aromatic amines 112-127 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 15122594-4 2004 Cytochrome p450 1B1 (CYP1B1) and sulfotransferase 1A1 (SULT1A1) are also involved in the metabolism of PAHs and aromatic amines. aromatic amines 112-127 sulfotransferase family 1A member 1 Homo sapiens 33-53 15122594-4 2004 Cytochrome p450 1B1 (CYP1B1) and sulfotransferase 1A1 (SULT1A1) are also involved in the metabolism of PAHs and aromatic amines. aromatic amines 112-127 sulfotransferase family 1A member 1 Homo sapiens 55-62 15122594-15 2004 NAT2 slow acetylator was associated with marginally increased risk of bladder cancer (OR = 1.50, 95% CI = 0.99-2.27), and the OR for the joint effect with occupational exposure of aromatic amines was 3.26 (95% CI = 1.06-9.95). aromatic amines 180-195 N-acetyltransferase 2 Homo sapiens 0-4 15712955-7 2004 The retention order of peaks of aromatic amines is related to their pKb and the numbers of amino and acidic groups. aromatic amines 32-47 protein tyrosine kinase 2 beta Homo sapiens 68-71 14582238-4 2003 Genetic polymorphisms that influence human genotoxic risk are those of glutathione s-transferase and cytochrome P450 in exposure to polycyclic aromatic hydrocarbons (PAHs), those of N-acetyltransferase in both occupational and environmental exposures to aromatic amines (AAs) and similar compounds. aromatic amines 254-269 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 101-116 12464797-16 2002 With the limitation that little is known about the tissue distribution and regulation of SULT1A2, the findings suggest that its polymorphism may affect the individual susceptibility towards procarcinogens, in particular certain aromatic amines and amides. aromatic amines 228-243 sulfotransferase family 1A member 2 Homo sapiens 89-96 12877350-2 2003 N-acetyltransferase (NAT2) is involved in the metabolic activation and detoxification of aromatic amines. aromatic amines 89-104 N-acetyltransferase 2 Homo sapiens 21-25 12872524-14 2003 In the pathogenesis of human bladder cancer due to occupational exposure to "classical" aromatic amines (benzidine, 4-aminodiphenyl, 1-naphthylamine) acetylation by NAT2 is regarded as a detoxication step. aromatic amines 88-103 N-acetyltransferase 2 Homo sapiens 165-169 12835615-1 2003 N-acetyltransferase (NAT) 1 and 2 and glutathione S-transferase (GST) M1 and T1 are phase II enzymes that are important for activation and detoxification of carcinogenic heterocyclic and aromatic amines, as present in cigarette smoke. aromatic amines 187-202 N-acetyltransferase 1 Homo sapiens 0-33 12835615-1 2003 N-acetyltransferase (NAT) 1 and 2 and glutathione S-transferase (GST) M1 and T1 are phase II enzymes that are important for activation and detoxification of carcinogenic heterocyclic and aromatic amines, as present in cigarette smoke. aromatic amines 187-202 glutathione S-transferase mu 1 Homo sapiens 38-72 12818290-1 2003 OBJECTIVE: Carcinogenic aromatic amines, derived from cooked meat, are activated or inactivated by hepatic N-acetyltransferase (NAT). aromatic amines 24-39 bromodomain containing 2 Homo sapiens 128-131 12686106-1 2003 Dopa decarboxylase (DDC) catalyzes as main reaction the stereospecific CO(2) abstraction from L-Dopa and L-5-hydroxytryptophan (5-HTP), generating the corresponding aromatic amines, dopamine and serotonin, respectively. aromatic amines 165-180 dopa decarboxylase Sus scrofa 0-18 12135113-2 2002 CYP1A2 is responsible for the activation of a number of aromatic amines to mutagenic and carcinogenic forms. aromatic amines 56-71 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-6 11266080-1 2001 The highly polymorphic N-acetyltransferases (NAT1 and NAT2) are involved in both activation and inactivation reactions of numerous carcinogens, such as tobacco derived aromatic amines. aromatic amines 168-183 N-acetyltransferase 1 Homo sapiens 45-49 11869833-0 2002 The enhanced bladder cancer susceptibility of NAT2 slow acetylators towards aromatic amines: a review considering ethnic differences. aromatic amines 76-91 N-acetyltransferase 2 Homo sapiens 46-50 11603126-1 2001 AIM: This study was designed to evaluate the impact of N-acetyltransferase 2 (NAT2, substrate: aromatic amines) in painters with bladder cancer and controls. aromatic amines 95-110 N-acetyltransferase 2 Homo sapiens 55-76 11369856-1 2001 Dopa decarboxylase (DDC) catalyzes not only the decarboxylation of L-aromatic amino acids but also side reactions including half-transamination of D-aromatic amino acids and oxidative deamination of aromatic amines. aromatic amines 199-214 dopa decarboxylase Homo sapiens 0-18 11304692-12 2001 Our results suggest that bladder-cancer risk can be genetically modulated by XRCC3, which may repair DNA cross-link lesions produced by aromatic amines and other environmental chemicals. aromatic amines 136-151 X-ray repair cross complementing 3 Homo sapiens 77-82 11767886-1 2001 An analytical method based on solid-phase extraction (SPE) with a polymeric material, HPLC separation on a modified C18 material, and diode-array detection is presented for the determination of aromatic amines in the ng L(-1)-concentration range. aromatic amines 194-209 Bardet-Biedl syndrome 9 Homo sapiens 116-119 11266080-1 2001 The highly polymorphic N-acetyltransferases (NAT1 and NAT2) are involved in both activation and inactivation reactions of numerous carcinogens, such as tobacco derived aromatic amines. aromatic amines 168-183 N-acetyltransferase 2 Homo sapiens 54-58 11027970-0 2000 Plant activation of aromatic amines mediated by cytochromes P450 and flavin-containing monooxygenases. aromatic amines 20-35 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 60-64 11156691-3 2001 Human CYP1B1 is involved in activation of chemically diverse human procarcinogens, including polycyclic aromatic hydrocarbons and some aromatic amines, as well as the endogenous hormone 17 beta-estradiol. aromatic amines 135-150 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 6-12 11027970-4 2000 Similarly, both inhibitors and methimazole did produce a significant decrease in 2-AF and m-PDA mutagenesis, when the activation system was S117, indicating that, similar to what occurs in mammalian systems, plant FMOs and cyt-P450s can metabolize aromatic amines to mutagenic product(s). aromatic amines 248-263 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 223-232 11598453-1 2001 INTRODUCTION/OBJECTIVE: N-acetyltransferase 2 (NAT2), mapped to 8p22, is a polymorphic enzyme which metabolizes aromatic amines. aromatic amines 112-127 N-acetyltransferase 2 Homo sapiens 24-45 11598453-1 2001 INTRODUCTION/OBJECTIVE: N-acetyltransferase 2 (NAT2), mapped to 8p22, is a polymorphic enzyme which metabolizes aromatic amines. aromatic amines 112-127 N-acetyltransferase 2 Homo sapiens 47-51 10868688-3 2000 N-acetyltransferases, encoded by the NAT1 and NAT2 genes are involved in the biotransformation of aromatic amines present in tobacco smoke, environment, and diet. aromatic amines 98-113 N-acetyltransferase 1 Homo sapiens 37-41 11465078-4 2000 Likewise, Cyp 1A2 activates a variety of bladder carcinogens, such as aromatic amines and amides. aromatic amines 70-85 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 10-17 10917203-3 2000 The rabbit CYP4B1 converts this prodrug and other furane analogs and aromatic amines, such as 2-aminoanthracene, to highly toxic alkylating metabolites, whereas the human isoenzyme exhibits only minimal enzymatic activity. aromatic amines 69-84 cytochrome P450 4B1 Oryctolagus cuniculus 11-17 10868688-3 2000 N-acetyltransferases, encoded by the NAT1 and NAT2 genes are involved in the biotransformation of aromatic amines present in tobacco smoke, environment, and diet. aromatic amines 98-113 N-acetyltransferase 2 Homo sapiens 46-50 10862520-1 2000 One major interest to analyse the extent of N-acetyltransferase 1 (NAT1*) allelic variation in the human population stems to a great extent from the possible association of interindividual differences in the metabolism of aromatic amines with certain chemically induced diseases, including cancer. aromatic amines 222-237 N-acetyltransferase 1 Homo sapiens 44-65 10862520-1 2000 One major interest to analyse the extent of N-acetyltransferase 1 (NAT1*) allelic variation in the human population stems to a great extent from the possible association of interindividual differences in the metabolism of aromatic amines with certain chemically induced diseases, including cancer. aromatic amines 222-237 N-acetyltransferase 1 Homo sapiens 67-72 11013410-8 2000 These results indicate that the newly developed strain OY1002/1A2 can be employed in detecting potential genotoxic aromatic amines requiring bioactivation by CYP1A2 and O-acetyltransferase. aromatic amines 115-130 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 158-164 10815690-2 2000 The ability to detoxify aromatic amines, which are present in tobacco and are potent bladder carcinogens, is compromised in persons with the N-acetyltransferase 2 slow acetylation polymorphism. aromatic amines 24-39 N-acetyltransferase 2 Homo sapiens 141-162 10676648-1 2000 Myeloperoxidase (MPO), an enzyme that is highly expressed in neutrophil leukocytes, transforms precarcinogens such as benzo(a)pyrene and aromatic amines to highly reactive intermediates. aromatic amines 137-152 myeloperoxidase Homo sapiens 0-15 10676648-1 2000 Myeloperoxidase (MPO), an enzyme that is highly expressed in neutrophil leukocytes, transforms precarcinogens such as benzo(a)pyrene and aromatic amines to highly reactive intermediates. aromatic amines 137-152 myeloperoxidase Homo sapiens 17-20 11013410-2 2000 We have previously reported that an umu tester strain, Salmonella typhimurium OY1001/1A2, endogenously coexpressing human CYP1A2 and NADPH-P450 reductase (reductase), is able to detect the genotoxicity of some aromatic amines [Aryal et al., 1999, Mutat Res 442:113-120]. aromatic amines 210-225 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 122-128 11013410-8 2000 These results indicate that the newly developed strain OY1002/1A2 can be employed in detecting potential genotoxic aromatic amines requiring bioactivation by CYP1A2 and O-acetyltransferase. aromatic amines 115-130 CAS1 domain containing 1 Homo sapiens 169-188 10859543-3 2000 The glutathione-S-transferase Mu1 enzyme (GSTM1) detoxifies arylepoxides which are formed after exposure to certain polycyclic aromatic hydrocarbons and possibly aromatic amines. aromatic amines 162-177 glutathione S-transferase mu 1 Homo sapiens 4-40 10859543-3 2000 The glutathione-S-transferase Mu1 enzyme (GSTM1) detoxifies arylepoxides which are formed after exposure to certain polycyclic aromatic hydrocarbons and possibly aromatic amines. aromatic amines 162-177 glutathione S-transferase mu 1 Homo sapiens 42-47 10506112-4 1999 UGT1A1, UGT1A4 and UGT1A9 each metabolized all of the aromatic amines. aromatic amines 54-69 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 0-6 10526205-0 1999 Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P450 1A2-catalyzed activation of aromatic amines. aromatic amines 157-172 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 113-132 10571250-1 1999 Arylamine N-acetyltransferase 1 (NAT1) conjugates several aromatic amines and their N-hydroxylated metabolites by N- or O-acetylation. aromatic amines 58-73 N-acetyltransferase 1 Homo sapiens 0-31 10571250-1 1999 Arylamine N-acetyltransferase 1 (NAT1) conjugates several aromatic amines and their N-hydroxylated metabolites by N- or O-acetylation. aromatic amines 58-73 N-acetyltransferase 1 Homo sapiens 33-37 10506112-4 1999 UGT1A1, UGT1A4 and UGT1A9 each metabolized all of the aromatic amines. aromatic amines 54-69 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 8-14 10506112-4 1999 UGT1A1, UGT1A4 and UGT1A9 each metabolized all of the aromatic amines. aromatic amines 54-69 UDP glucuronosyltransferase family 1 member A9 Homo sapiens 19-25 10506112-8 1999 UGT1A6 was effective in metabolizing only four of the eight aromatic amines tested. aromatic amines 60-75 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 0-6 10506112-10 1999 UGT2B7 was the only product of the UGT2 gene family examined and it metabolized all the aromatic amines at similar low relative levels compared with a preferred substrate, 4-OH-estrone. aromatic amines 88-103 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 0-6 10506112-10 1999 UGT2B7 was the only product of the UGT2 gene family examined and it metabolized all the aromatic amines at similar low relative levels compared with a preferred substrate, 4-OH-estrone. aromatic amines 88-103 solute carrier family 35 member A2 Homo sapiens 0-4 10224318-2 1999 CYP1A2 is induced by and metabolizes polyaromatic hydrocarbons (PAH) and aromatic amines and could modify effects of exposure to ambient air pollution. aromatic amines 73-88 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-6 10503885-1 1999 The localization of human arylamine acetyltransferases (NAT) transcripts was performed by non-isotopic in situ hybridization, utilizing a combination of six NAT1 or NAT2 specific antisense oligonucleotide probes, in order to identify those tissues and organs that might be susceptible to the carcinogenic effects of aromatic amines. aromatic amines 316-331 bromodomain containing 2 Homo sapiens 56-59 10393280-3 1999 Membrane fractions, when isolated from this tester strain, contained 0.04 P450 nmol/mg protein and a reductase activity of 170 nmol cytochrome c reduced/min/mg protein and were active in catalyzing CYP1A2-dependent 7-ethoxyresorufin O-deethylation and metabolic activation of heterocyclic aromatic amines to DNA-damaging products in a conventional tester S. typhimurium NM2009 strain, only when NADPH was added as a reducing equivalent. aromatic amines 289-304 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 198-204 10508415-1 1999 Ceruloplasmin, a blue multi-copper alpha(2)-glycoprotein found in the plasma of all vertebrates, is capable of oxidizing aromatic amines and ferrous iron. aromatic amines 121-136 ceruloplasmin Homo sapiens 0-13 10403632-9 1999 The above findings raise the possibility that a cytochrome P450-like protein, that can receive electrons from NADH, possibly through cytochrome b5 reductase, is present in the hepatic microsomes of rats and mice, and is capable of catalysing the bioactivation of aromatic amines through N-hydroxylation. aromatic amines 263-278 cytochrome P450, family 4, subfamily v, polypeptide 3 Rattus norvegicus 48-76 10599336-5 1999 NAT-2 is the most important enzyme in acetylation of aromatic amines, and thus may be responsible for detoxification of many of these compounds. aromatic amines 53-68 N-acetyltransferase 2 Homo sapiens 0-5 10026165-3 1999 We also show that the reaction specificity of Dopa decarboxylase toward aromatic amines depends on the experimental conditions. aromatic amines 72-87 dopa decarboxylase Homo sapiens 46-64 9626971-4 1998 There is very little information available about these substances, but they share the property of belonging to the same class (aromatic amines) as MOCA. aromatic amines 127-142 dedicator of cyto-kinesis 3 Mus musculus 147-151 9806162-2 1998 The aromatic amines and their metabolites, a class of carcinogens present in tobacco smoke, undergo metabolism (activation or detoxification) through an N- or O-acetylation pathway by the polymorphic enzymes, N-acetyltransferases (NAT)1 or NAT2. aromatic amines 4-19 N-acetyltransferase 2 Homo sapiens 240-244 9666727-1 1998 An amperometric flow system combined with a glucose oxidase-mutarotase reactor was optimized and used to determine aromatic amines and phenols using peroxidase-modified graphite electrodes. aromatic amines 115-130 peroxidase N1 Nicotiana tabacum 149-159 9854023-2 1999 A major human sulphotransferase, SULT1A1 (P-PST), metabolizes and/or bioactivates many drugs, iodothyronines and hydroxylated aromatic amines. aromatic amines 126-141 sulfotransferase family 1A member 1 Homo sapiens 33-40 9854023-2 1999 A major human sulphotransferase, SULT1A1 (P-PST), metabolizes and/or bioactivates many drugs, iodothyronines and hydroxylated aromatic amines. aromatic amines 126-141 sulfotransferase family 1A member 1 Homo sapiens 42-47 9679939-0 1998 Alterations of the p53 gene in occupational bladder cancer in workers exposed to aromatic amines. aromatic amines 81-96 tumor protein p53 Homo sapiens 19-22 9681534-2 1998 But cruciferous vegetables also induce cytochrome P4501A2 (CYP1A2), which catalyzes the metabolic activation of various procarcinogens, including aromatic amines in tobacco. aromatic amines 146-161 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 39-57 9681534-2 1998 But cruciferous vegetables also induce cytochrome P4501A2 (CYP1A2), which catalyzes the metabolic activation of various procarcinogens, including aromatic amines in tobacco. aromatic amines 146-161 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 59-65 9371491-2 1997 Myeloperoxidase activates benzo[a]pyrene as well as aromatic amines in tobacco smoke and generates carcinogen-free radicals. aromatic amines 52-67 myeloperoxidase Homo sapiens 0-15 23899331-3 1998 T he human N -acetyltransferase 1 (NAT 1) enzyme can activate or deactivate aromatic amines, making it a candidate genetic susceptibility gene. aromatic amines 76-91 N-acetyltransferase 1 Homo sapiens 11-33 23899331-3 1998 T he human N -acetyltransferase 1 (NAT 1) enzyme can activate or deactivate aromatic amines, making it a candidate genetic susceptibility gene. aromatic amines 76-91 N-acetyltransferase 1 Homo sapiens 35-40 9426406-0 1997 Alterations of the p53 gene in occupational bladder cancer in workers exposed to aromatic amines. aromatic amines 81-96 tumor protein p53 Homo sapiens 19-22 9426406-2 1997 In the present study, p53 gene mutations in 26 patients with bladder lesions occupationally exposed to aromatic amines were examined by single-strand conformation polymorphism analysis of PCR-amplified DNA segments, followed by direct sequencing. aromatic amines 103-118 tumor protein p53 Homo sapiens 22-25 9550098-6 1997 Since these enzymes (EROD, CYP 1A1/2 and PROD, CYP2B1) activate polycyclic hydrocarbons, aromatic amines and aliphatic halogenated hydrocarbons to their ultimate mutagenic or carcinogenic forms, and are effective in producing reactive oxygen species such as superoxide, hydroxyl radical and hydrogen peroxide, the new compound, BITN, appears to have a greater anticarcinogenic and antioxidant potential than RA and BHT. aromatic amines 89-104 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 27-34 9550098-6 1997 Since these enzymes (EROD, CYP 1A1/2 and PROD, CYP2B1) activate polycyclic hydrocarbons, aromatic amines and aliphatic halogenated hydrocarbons to their ultimate mutagenic or carcinogenic forms, and are effective in producing reactive oxygen species such as superoxide, hydroxyl radical and hydrogen peroxide, the new compound, BITN, appears to have a greater anticarcinogenic and antioxidant potential than RA and BHT. aromatic amines 89-104 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 47-53 9295230-4 1997 This observation prompted us to investigate whether the cytosolic activation of aromatic amines is associated with the Ah receptor. aromatic amines 80-95 aryl hydrocarbon receptor Rattus norvegicus 119-130 9397191-6 1997 Northern blot analyses indicated that both amines markedly induced CYP2B10 mRNA, whereas CYP1A2 mRNA, the enzyme implicated in the bioactivation of aromatic amines and frequently induced by aromatic amines, was induced only slightly, a response that was not different from that seen with PB. aromatic amines 148-163 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 89-95 9397191-6 1997 Northern blot analyses indicated that both amines markedly induced CYP2B10 mRNA, whereas CYP1A2 mRNA, the enzyme implicated in the bioactivation of aromatic amines and frequently induced by aromatic amines, was induced only slightly, a response that was not different from that seen with PB. aromatic amines 190-205 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 89-95 9356307-12 1997 The two inbred rat strains did not differ in hepatic microsomal phenacetin deethylase activity, which is a marker for CYP1A2 activity important for the activation of aromatic amines. aromatic amines 166-181 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 118-124 9310344-13 1997 These findings suggested that CYP4B1 could contribute to the initiation of carcinogenesis in rat and mouse bladder by activation of aromatic amines. aromatic amines 132-147 cytochrome P450, family 4, subfamily b, polypeptide 1 Rattus norvegicus 30-36 9295230-6 1997 These findings indicate that the bioactivation of aromatic amines by the liver cytosol is linked to the Ah receptor. aromatic amines 50-65 aryl hydrocarbon receptor Rattus norvegicus 104-115 9244789-0 1997 [Relationships "structure--methemoglobin-forming activity" in the series of aromatic amines]. aromatic amines 76-91 hemoglobin subunit gamma 2 Homo sapiens 27-40 9168895-5 1997 However, the G445A (Val149-->Ile) substitution yielded expression of recombinant NAT1 protein that catalyzed the N-acetylation of aromatic amines and the O- and N,O-acetylation of their N-hydroxylated metabolites at rates up to 2-fold higher than wild-type recombinant human NAT1. aromatic amines 133-148 N-acetyltransferase 1 Homo sapiens 84-88 9891107-1 1997 The study was designed to assess occupational and non-occupational risk factors in patients with urothelial carcinomas in an area of former coal, iron, and steel industries, with special regard to the impacts of polymorphic enzymes involved in the metabolism of aromatic amines (N-acetyltransferase 2, NAT2) and of polycyclic aromatic hydrocarbons (glutathione S-transferase micro, GSTM1). aromatic amines 262-277 N-acetyltransferase 2 Homo sapiens 279-300 9137809-1 1997 Polymorphic aromatic amine N-acetyltransferase (NAT2) catalyzes the N-acetylation of aromatic amines and the metabolic activation of N-hydroxyarylamines (via O-acetylation) and N-hydroxy-N-acetylarylamines (via N,O-acetylation) to electrophilic intermediates that mutate DNA. aromatic amines 85-100 arylamine N-acetyltransferase 2 Mesocricetus auratus 48-52 9070359-12 1997 No difference was observed between rapid and slow acetylator recombinant NAT2 proteins to activate aromatic amines by O- or N,O-acetylation, in substrate specificity, expression of immunoreactive protein, electrophoretic mobility, or N-acetyltransferase Michaelis-Menten kinetic constants. aromatic amines 99-114 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 73-77 9332704-5 1997 We therefore investigated whether changes in the phosphorylation status would influence the activities of the N-acetyltransferases NAT1 and/or NAT2, being responsible for one of the two major pathways leading to the ultimate mutagens, the reactive esters which are derived from the N-hydroxylated metabolites of aromatic amines. aromatic amines 312-327 N-acetyltransferase 1 Rattus norvegicus 131-135 9891107-12 1997 The results are consistent with the view that a slow-acetylator status and lack of the GSTM1 gene are individual risk factors for bladder cancer in persons occupationally exposed to aromatic amines and PAHs. aromatic amines 182-197 glutathione S-transferase mu 1 Homo sapiens 87-92 9137809-7 1997 The C727T substitution, which creates an opal stop codon in slow acetylator NAT2, was the sole mutation responsible for substantial reduction in expression of a truncated NAT2 protein with reduced capacity for the deactivation of aromatic amines (N-acetylation) and the metabolic activation of N-hydroxyarylamines (O-acetylation) and N-hydroxy-N-acetylarylamines (N,O-acetylation). aromatic amines 230-245 arylamine N-acetyltransferase 2 Mesocricetus auratus 76-80 9332704-5 1997 We therefore investigated whether changes in the phosphorylation status would influence the activities of the N-acetyltransferases NAT1 and/or NAT2, being responsible for one of the two major pathways leading to the ultimate mutagens, the reactive esters which are derived from the N-hydroxylated metabolites of aromatic amines. aromatic amines 312-327 N-acetyltransferase 2 Rattus norvegicus 143-147 9137809-7 1997 The C727T substitution, which creates an opal stop codon in slow acetylator NAT2, was the sole mutation responsible for substantial reduction in expression of a truncated NAT2 protein with reduced capacity for the deactivation of aromatic amines (N-acetylation) and the metabolic activation of N-hydroxyarylamines (O-acetylation) and N-hydroxy-N-acetylarylamines (N,O-acetylation). aromatic amines 230-245 arylamine N-acetyltransferase 2 Mesocricetus auratus 171-175 8773572-7 1996 These findings support the hypothesis that aromatic amines are metabolized in the bladder epithelium by NAT1. aromatic amines 43-58 N-acetyltransferase 1 Homo sapiens 104-108 9020311-7 1997 The plant activation of these aromatic amines is mediated by tobacco cell peroxidase. aromatic amines 30-45 peroxidase N1-like Nicotiana tabacum 74-84 8761425-7 1996 Our results suggest that smoking coke oven workers with genotypes unfavourable for detoxification of aromatic amines (NAT2-ss) and PAH (GSTM1-null) may have an increased risk of developing bladder cancer. aromatic amines 101-116 N-acetyltransferase 2 Homo sapiens 118-122 8781405-1 1996 The aromatic amines 2,4-diaminotoluene (2,4-DAT) and 2,6-diaminotoluene (2,6-DAT) are structural isomers that have been extensively studied for their mutagenic and carcinogenic characteristics. aromatic amines 4-19 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus 44-47 8643532-1 1996 Several epidemiologic studies indicate that NAT2-related slow N-acetylation increases bladder cancer risk among workers exposed to aromatic amines, presumably because N-acetylation is important for the detoxification of these compounds. aromatic amines 131-146 N-acetyltransferase 2 Homo sapiens 44-48 8781405-1 1996 The aromatic amines 2,4-diaminotoluene (2,4-DAT) and 2,6-diaminotoluene (2,6-DAT) are structural isomers that have been extensively studied for their mutagenic and carcinogenic characteristics. aromatic amines 4-19 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus 77-80 8967723-3 1996 Exposure to aromatic amines in dyestuff manufacture, in the rubber and textile industry, occupations entailing exposure to paints and solvents, leather dust, inks, some metals, PAH, combustion products and diesel exhausts have been identified as risk factors from epidemiological studies. aromatic amines 12-27 phenylalanine hydroxylase Homo sapiens 177-180 8920635-8 1996 For example, while some endogenously-occurring aromatic amines such as tyramine and tryptamine are metabolized well by SSAO in homogenates of rat blood vessels, and also in vitro inhibition of SSAO can potentiate vasoconstrictor actions of these amines in rat vascular preparations, these amines are poor substrates for human SSAO, thus complicating attempts to generalize possible physiological roles for these enzymes. aromatic amines 47-62 amine oxidase, copper containing 3 Rattus norvegicus 119-123 8920635-8 1996 For example, while some endogenously-occurring aromatic amines such as tyramine and tryptamine are metabolized well by SSAO in homogenates of rat blood vessels, and also in vitro inhibition of SSAO can potentiate vasoconstrictor actions of these amines in rat vascular preparations, these amines are poor substrates for human SSAO, thus complicating attempts to generalize possible physiological roles for these enzymes. aromatic amines 47-62 amine oxidase, copper containing 3 Rattus norvegicus 193-197 8920635-8 1996 For example, while some endogenously-occurring aromatic amines such as tyramine and tryptamine are metabolized well by SSAO in homogenates of rat blood vessels, and also in vitro inhibition of SSAO can potentiate vasoconstrictor actions of these amines in rat vascular preparations, these amines are poor substrates for human SSAO, thus complicating attempts to generalize possible physiological roles for these enzymes. aromatic amines 47-62 amine oxidase copper containing 2 Homo sapiens 193-197 18623183-0 1995 Removal of phenols and aromatic amines from wastewater by a combination treatment with tyrosinase and a coagulant. aromatic amines 23-38 tyrosinase Homo sapiens 87-97 9017438-1 1996 Previously, we found a decrease in CD4 + CD45RA + T lymphocytes in workers exposed to the aromatic amines (AAs) [benzidine (BZ) and beta naphthylamine (BNA)]. aromatic amines 90-105 CD4 molecule Homo sapiens 35-38 8671708-4 1996 In this paper, I propose that lactoperoxidase and myeloperoxidase activate aromatic amines, within the breast ducts, and that these enzymes play a crucial role in the chemical induction of breast cancer. aromatic amines 75-90 myeloperoxidase Homo sapiens 50-65 7618953-1 1995 Previously, we reported a decrease of CD4+ T lymphocytes in workers exposed to benzidine and beta-naphthylamine, which are aromatic amines. aromatic amines 123-138 CD4 molecule Homo sapiens 38-41 7618953-7 1995 It is suggested that the CD4+CD45RA+ T lymphocyte is a major site of the effects of aromatic amines on lymphocyte subpopulations. aromatic amines 84-99 CD4 molecule Homo sapiens 25-28 18623183-1 1995 Removal of phenols and aromatic amines from industrial wastewater by tyrosinase was investigated. aromatic amines 23-38 tyrosinase Homo sapiens 69-79 18623183-6 1995 These results indicate that the combination of tyrosinase and a cationic polymer coagulant is effective in removing carcinogenic phenols and aromatic amines from an aqueous solution. aromatic amines 141-156 tyrosinase Homo sapiens 47-57 7585580-2 1995 The aromatic amines and their metabolites, a class of carcinogen implicated in these exposures, can be N- or O-acetylated by the NAT1 and NAT2 enzymes. aromatic amines 4-19 N-acetyltransferase 1 Homo sapiens 129-133 7585580-2 1995 The aromatic amines and their metabolites, a class of carcinogen implicated in these exposures, can be N- or O-acetylated by the NAT1 and NAT2 enzymes. aromatic amines 4-19 N-acetyltransferase 2 Homo sapiens 138-142 7586147-1 1995 The aromatic amines 2,4-diaminotoluene (2,4-DAT) and 2,6-diaminotoluene (2,6-DAT) are structural isomers that have been extensively studied for their mutagenic and carcinogenic characteristics. aromatic amines 4-19 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus 44-47 7586147-1 1995 The aromatic amines 2,4-diaminotoluene (2,4-DAT) and 2,6-diaminotoluene (2,6-DAT) are structural isomers that have been extensively studied for their mutagenic and carcinogenic characteristics. aromatic amines 4-19 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus 77-80 24222057-1 1995 3: H/D exchange reactions of protonated aromatic amines with ND3. aromatic amines 40-55 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 61-64 7850792-0 1995 Bioactivation of aromatic amines by recombinant human cytochrome P4501A2 expressed in Ames tester strain bacteria: a substitute for activation by mammalian tissue preparations. aromatic amines 17-32 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 54-72 24222057-2 1995 The H/D exchange reactions of a variety of protonated aromatic amines with ND3 m the collision cell of a hybrid BEqQ tandem mass spectrometer have been studied. aromatic amines 54-69 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 75-78 7699577-3 1995 Carcinogenic aromatic amines such as heterocyclic aromatic amines and aminoazo dyes induced predominantly cytochrome P450IA2 (CYP1A2), which is responsible for the mutagenic activation and N-hydroxylation of the amines in the rodent. aromatic amines 13-28 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 126-132 8102843-7 1993 Perhaps the number of circulating CD4+ T lymphocytes decreases in workers exposed to aromatic amines. aromatic amines 85-100 CD4 molecule Homo sapiens 34-37 7894498-2 1994 The rabbit CYP4B1 enzyme exhibits activity towards procarcinogenic aromatic amines. aromatic amines 67-82 cytochrome P450 4B1 Oryctolagus cuniculus 11-17 8179586-3 1994 However, among ionic metals used only lead showed inhibitory effects on the microsomal activity for CYP1A2-dependent mutagenesis of aromatic amines and on the expression of mRNA and protein of the enzyme, indicating that ionic lead is a unique inhibitor for the expression of CYP1A2 enzyme in the rat liver. aromatic amines 132-147 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 100-106 8130776-4 1993 As determined by a bacterial mutation test using carcinogenic aromatic amines are P450IA enzyme substrates, CCl4 treatment selectively inhibited the activity of P450IA2 in the MC-induced isozymes. aromatic amines 62-77 C-C motif chemokine ligand 4 Rattus norvegicus 108-112 8102843-8 1993 It is concluded that measurement of CD4+ lymphocytes provides a useful biological marker of past exposure to aromatic amines. aromatic amines 109-124 CD4 molecule Homo sapiens 36-39 1383750-0 1992 Use of a newly developed tester strain Salmonella typhimurium NM2009 for the study of metabolic activation of carcinogenic aromatic amines by rat liver microsomal cytochrome P-450 enzymes. aromatic amines 123-138 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 163-179 8423501-4 1993 Cytochrome P4501A1, P4502E1 and N-acetyl transferase 2 are examples of enzymes involved in the metabolic activation of potential environmental carcinogens such as polycyclic aromatic hydrocarbons, benzene, and aromatic amines, respectively. aromatic amines 210-225 N-acetyltransferase 2 Homo sapiens 20-54 1486865-6 1992 Peroxidative activation of aromatic amines can also occur, especially from prostaglandin H synthase in the urinary bladder and myeloperoxidase in the lungs of cigarette smokers, and both show considerable individual variability, apparently due to the extent of tissue inflammation. aromatic amines 27-42 myeloperoxidase Homo sapiens 127-142