PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16989056-2	1991	The first case, a 8 year old girl, suffered a severe encefalopathy after topical application of mydriatic cholirio as an aid in a rutine study of ocular refraction.	Rutin	130-136	activation induced cytidine deaminase	Homo sapiens	121-124
1768430-10	1991	Pyrazole, progesterone and phenobarbital did not inhibit, whereas dicoumarol, rutin and indomethacin inhibited NQR activity in murine skin and liver as well as in human keratinocytes.	Rutin	78-83	crystallin zeta	Homo sapiens	111-114
1681063-5	1991	Reversible binding of 500 microM p-NP glucopyranoside to 4% HSA (25.8 +/- 2.82%) was comparable with that of the glucuronide, with which it is structurally similar.	Rutin	38-53	purine nucleoside phosphorylase	Homo sapiens	33-37
33785814-9	2021	The results also showed that rutin decreased the expression of Bcl2 and MDA concentration (P < 0.05).	Rutin	29-34	BCL2, apoptosis regulator	Rattus norvegicus	63-67
33798836-3	2021	Flavonoids, especially rutin, have attracted considerable interest as a prospective SARS-CoV-2 main protease (Mpro) inhibitor.	Rutin	23-28	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	110-114
33785814-11	2021	Rutin induces apoptosis by the expression of Bcl-2, Bax and caspase and also antioxidant activity by increasing antioxidants concentrations.	Rutin	0-5	BCL2, apoptosis regulator	Rattus norvegicus	45-50
33785814-11	2021	Rutin induces apoptosis by the expression of Bcl-2, Bax and caspase and also antioxidant activity by increasing antioxidants concentrations.	Rutin	0-5	BCL2 associated X, apoptosis regulator	Rattus norvegicus	52-55
34959709-0	2021	Mulberry Leaf Polyphenol Extract and Rutin Induces Autophagy Regulated by p53 in Human Hepatoma HepG2 Cells.	Rutin	37-42	tumor protein p53	Homo sapiens	74-77
34419830-1	2022	Bovine serum albumin (BSA) has been used as a transporter protein for levothyroxine (LT4) and rutin, due to its property of binding to various ligands.	Rutin	94-99	albumin	Homo sapiens	7-20
34780892-4	2021	In contrast, Ram2 enzyme showed a substrate specificity towards alpha-(1 6) glycosidic flavonoids, such as rutin, and the disaccharide rutinose.	Rutin	107-112	alpha-L-rhamnosidase	Lactobacillus plantarum WCFS1	13-17
33811574-13	2021	Altogether, the study showed that the prevention and reversal treatments of mice with rutin attenuated ketamine-induced schizophrenic-like behaviors via reduction of Nox-2 expression, oxidative/nitrergic stresses, acetylcholinesterase activity, and increased GAD67 enzyme.	Rutin	86-91	cytochrome b-245, beta polypeptide	Mus musculus	166-171
33811574-13	2021	Altogether, the study showed that the prevention and reversal treatments of mice with rutin attenuated ketamine-induced schizophrenic-like behaviors via reduction of Nox-2 expression, oxidative/nitrergic stresses, acetylcholinesterase activity, and increased GAD67 enzyme.	Rutin	86-91	acetylcholinesterase	Mus musculus	214-234
33031932-0	2020	Rutin prevents cisplatin-induced ovarian damage via antioxidant activity and regulation of PTEN and FOXO3a phosphorylation in mouse model.	Rutin	0-5	phosphatase and tensin homolog	Mus musculus	91-95
33031932-0	2020	Rutin prevents cisplatin-induced ovarian damage via antioxidant activity and regulation of PTEN and FOXO3a phosphorylation in mouse model.	Rutin	0-5	forkhead box O3	Mus musculus	100-106
33031932-12	2020	In conclusion, treatment with 10 mg/Kg rutin has the potential to protect the ovarian follicles against cisplatin-induced toxicity through its antioxidant effects and PTEN/FOXO3a pathway.	Rutin	39-44	phosphatase and tensin homolog	Mus musculus	167-171
33031932-12	2020	In conclusion, treatment with 10 mg/Kg rutin has the potential to protect the ovarian follicles against cisplatin-induced toxicity through its antioxidant effects and PTEN/FOXO3a pathway.	Rutin	39-44	forkhead box O3	Mus musculus	172-178
24549762-8	2014	We also observed that rutin repressed rotenone-induced c-Jun N-terminal kinase and p38 mitogen-activated protein kinase phosphorylation.	Rutin	22-27	mitogen-activated protein kinase 14	Homo sapiens	83-86
34839052-4	2022	Rutin was intragastrically administered continuously for 5 days at a dose of 200 mg/kg/d, and pharmacokinetic and pharmacodynamic indicators were measured every day after administration, including the blood concentration of rutin, the W/D ratio of lungs, the nitric oxide content and the expression levels of TLR4, TRAF6, IkappaB and P-IkappaB proteins.	Rutin	0-5	toll-like receptor 4	Mus musculus	309-313
34839052-4	2022	Rutin was intragastrically administered continuously for 5 days at a dose of 200 mg/kg/d, and pharmacokinetic and pharmacodynamic indicators were measured every day after administration, including the blood concentration of rutin, the W/D ratio of lungs, the nitric oxide content and the expression levels of TLR4, TRAF6, IkappaB and P-IkappaB proteins.	Rutin	0-5	TNF receptor-associated factor 6	Mus musculus	315-320
34864228-0	2022	Discovery of TGFBR1 (ALK5) as a potential drug target of quercetin glycoside derivatives (QGDs) by reverse molecular docking and molecular dynamics simulation.	Rutin	57-76	transforming growth factor beta receptor 1	Homo sapiens	13-19
34864228-0	2022	Discovery of TGFBR1 (ALK5) as a potential drug target of quercetin glycoside derivatives (QGDs) by reverse molecular docking and molecular dynamics simulation.	Rutin	57-76	transforming growth factor beta receptor 1	Homo sapiens	21-25
34459013-9	2021	Rutin directly inhibited rat testicular CYP17A1, HSD17B3 and AKR1C14 activities at 50 muM.	Rutin	0-5	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	40-47
34964624-2	2022	Results from thioflavin T assay demonstrated that gallic acid, caffeic acid, and rutin and its aglycone, quercetin, inhibited IAPP fibrillation at 1:0.5, 1:1, and 1:2 IAPP-phenolic molar ratios.	Rutin	81-86	islet amyloid polypeptide	Homo sapiens	126-130
34964624-2	2022	Results from thioflavin T assay demonstrated that gallic acid, caffeic acid, and rutin and its aglycone, quercetin, inhibited IAPP fibrillation at 1:0.5, 1:1, and 1:2 IAPP-phenolic molar ratios.	Rutin	81-86	islet amyloid polypeptide	Homo sapiens	167-171
34964624-7	2022	Molecular docking and TEM showed that rutin and quercetin disaggregated preformed IAPP fibrils potentially through fibrillar-monomeric equilibrium shifts.	Rutin	38-43	islet amyloid polypeptide	Homo sapiens	82-86
34459013-9	2021	Rutin directly inhibited rat testicular CYP17A1, HSD17B3 and AKR1C14 activities at 50 muM.	Rutin	0-5	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	49-56
34459013-9	2021	Rutin directly inhibited rat testicular CYP17A1, HSD17B3 and AKR1C14 activities at 50 muM.	Rutin	0-5	aldo-keto reductase family 1, member C14	Rattus norvegicus	61-68
33907040-6	2021	The results revealed that rutin pretreatment reduced the expression of the proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 and increased the secretion of interleukin-10.	Rutin	26-31	interleukin 6	Mus musculus	153-166
34649146-6	2021	Through text mining, thirty phytochemicals were reported from B. asiatica, of which, three phytochemicals (Berbamine, Oxyacanthine, and Rutin) show high affinity with the SARS-CoV-2 Mpro and exhibited favorable intermolecular interactions with the catalytic residues (His41 and Cys145) and other essential residues.	Rutin	136-141	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	182-186
34649146-8	2021	The number of H-bonds and MMPBSA results also demonstrates that Berbamine, Oxyacanthine, and Rutin are potent Mpro inhibitors having free energy of -20.79, -33.35, and -31.12 kcal mol-1 respectively.	Rutin	93-98	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	110-114
33907040-6	2021	The results revealed that rutin pretreatment reduced the expression of the proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 and increased the secretion of interleukin-10.	Rutin	26-31	tumor necrosis factor	Mus musculus	101-128
33907040-6	2021	The results revealed that rutin pretreatment reduced the expression of the proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 and increased the secretion of interleukin-10.	Rutin	26-31	interleukin 1 beta	Mus musculus	130-147
33907040-6	2021	The results revealed that rutin pretreatment reduced the expression of the proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 and increased the secretion of interleukin-10.	Rutin	26-31	interleukin 10	Mus musculus	198-212
33907040-7	2021	Rutin pretreatment also downregulated the expression of the M1 microglial markers CD86 and inducible nitric oxide synthase and upregulated the expression of the M2 microglial markers arginase 1 and CD206.	Rutin	0-5	CD86 antigen	Mus musculus	82-86
33907040-7	2021	Rutin pretreatment also downregulated the expression of the M1 microglial markers CD86 and inducible nitric oxide synthase and upregulated the expression of the M2 microglial markers arginase 1 and CD206.	Rutin	0-5	nitric oxide synthase 2, inducible	Mus musculus	91-122
33907040-7	2021	Rutin pretreatment also downregulated the expression of the M1 microglial markers CD86 and inducible nitric oxide synthase and upregulated the expression of the M2 microglial markers arginase 1 and CD206.	Rutin	0-5	arginase, liver	Mus musculus	183-193
33907040-7	2021	Rutin pretreatment also downregulated the expression of the M1 microglial markers CD86 and inducible nitric oxide synthase and upregulated the expression of the M2 microglial markers arginase 1 and CD206.	Rutin	0-5	mannose receptor, C type 1	Mus musculus	198-203
33907040-8	2021	Rutin pretreatment inhibited the expression of Toll-like receptor 4 and myeloid differentiation factor 88 and blocked the phosphorylation of I kappa B kinase and nuclear factor-kappa B.	Rutin	0-5	toll-like receptor 4	Mus musculus	47-67
34728718-11	2021	MD simulation validated the stability of four chemicals at the MAPK6 binding pockets, including Assafoetidinol A (ASA), Naringin (NAR), Rutin (RUT), and Tomatine (TOM).	Rutin	136-141	mitogen-activated protein kinase 6	Homo sapiens	63-68
34461126-8	2021	Natural products like asiatic acid, diosmin, rutin, and so forth have shown significant potential in activating Nrf2 pathway which can lead to attenuate cholestatic liver injury.	Rutin	45-50	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
34728718-11	2021	MD simulation validated the stability of four chemicals at the MAPK6 binding pockets, including Assafoetidinol A (ASA), Naringin (NAR), Rutin (RUT), and Tomatine (TOM).	Rutin	143-146	mitogen-activated protein kinase 6	Homo sapiens	63-68
34384828-7	2021	However, rutin efficiently reduced MDA level, CRP and NF-kappaB; increasing SOD, GSH and Nrf2 levels in DBP and BPA exposed rats.	Rutin	9-14	C-reactive protein	Rattus norvegicus	46-49
34384828-0	2021	Rutin prevents cardiac oxidative stress and inflammation induced by bisphenol A and dibutyl phthalate exposure via NRF-2/NF-kappaB pathway.	Rutin	0-5	NFE2 like bZIP transcription factor 2	Rattus norvegicus	115-120
34829567-11	2021	In conclusion, rutin and rutin glycoside showed differences in antioxidant activities in vitro, while they were similar in the reduction of NO, PGE2, TNF-alpha and IL-6 in vitro.	Rutin	15-20	tumor necrosis factor	Mus musculus	150-159
34829567-11	2021	In conclusion, rutin and rutin glycoside showed differences in antioxidant activities in vitro, while they were similar in the reduction of NO, PGE2, TNF-alpha and IL-6 in vitro.	Rutin	15-20	interleukin 6	Mus musculus	164-168
34690453-12	2021	MM-PBSA provided the basis for analyzing the affinity of the phytochemicals towards Mpro by calculating the binding energy, and secondary structure analysis indicated the stability of protease structure when it is bound to Rutin and Plebeiosides B.	Rutin	223-228	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	84-88
34690453-13	2021	Altogether, the study identifies Rutin and Plebeiosides B to be potent Mpro inhibitors of SARS-CoV-2.	Rutin	33-38	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	71-75
34384828-7	2021	However, rutin efficiently reduced MDA level, CRP and NF-kappaB; increasing SOD, GSH and Nrf2 levels in DBP and BPA exposed rats.	Rutin	9-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	89-93
34384828-8	2021	SIGNIFICANCE: These results revealed that bisphenol and dibutyl phthalate exposure caused oxidative stress and inflammation in the heart through Nrf2/NF-kappaB signaling pathway while oral administration of rutin prevents these effects via upregulation of Nrf2 and suppression of NF-kappaB signaling pathway.	Rutin	207-212	NFE2 like bZIP transcription factor 2	Rattus norvegicus	256-260
34350508-5	2021	Docking results showed that rutin, puerarin, baicalin, luteolin and quercetin are the most potent TXNIP inhibitors, and among them, rutin as the most effective flavonoid.	Rutin	28-33	thioredoxin interacting protein	Homo sapiens	98-103
34350508-5	2021	Docking results showed that rutin, puerarin, baicalin, luteolin and quercetin are the most potent TXNIP inhibitors, and among them, rutin as the most effective flavonoid.	Rutin	132-137	thioredoxin interacting protein	Homo sapiens	98-103
34339905-0	2021	Rutin promotes activation and reduces apoptosis of primordial follicles by regulating Akt phosphorylation after in vitro culture of ovine ovarian tissue.	Rutin	0-5	RAC-alpha serine/threonine-protein kinase	Ovis aries	86-89
34126182-7	2021	These results demonstrate that DSG1 deficiency is a potential cause of cutaneous eruptions caused by the combination of SHL and ASA, and neochlorogenic acid and rutin are the main allergenic components.	Rutin	161-166	desmoglein 1	Homo sapiens	31-35
34339905-10	2021	In conclusion, rutin at 1 mug/mL reduces apoptosis, promotes activation and growth of sheep primordial follicles through the modulation of the PI3K/Akt signaling pathway after in vitro culture of ovine ovarian tissue.	Rutin	15-20	RAC-alpha serine/threonine-protein kinase	Ovis aries	148-151
34577000-4	2021	Hence, we hypothesized that rutin could exhibit strong inhibitory efficacy against Jab1 and, thereby, induce significant growth arrest in SiHa cancer cells in a dose-dependent manner.	Rutin	28-33	COP9 signalosome subunit 5	Homo sapiens	83-87
34302158-0	2021	Rutin prevents inflammation-associated colon damage via inhibiting the p38/MAPKAPK2 and PI3K/Akt/GSK3beta/NF-kappaB signalling axes and enhancing splenic Tregs in DSS-induced murine chronic colitis.	Rutin	0-5	mitogen-activated protein kinase 14	Mus musculus	71-74
34302158-0	2021	Rutin prevents inflammation-associated colon damage via inhibiting the p38/MAPKAPK2 and PI3K/Akt/GSK3beta/NF-kappaB signalling axes and enhancing splenic Tregs in DSS-induced murine chronic colitis.	Rutin	0-5	MAP kinase-activated protein kinase 2	Mus musculus	75-83
34302158-0	2021	Rutin prevents inflammation-associated colon damage via inhibiting the p38/MAPKAPK2 and PI3K/Akt/GSK3beta/NF-kappaB signalling axes and enhancing splenic Tregs in DSS-induced murine chronic colitis.	Rutin	0-5	thymoma viral proto-oncogene 1	Mus musculus	93-96
34302158-0	2021	Rutin prevents inflammation-associated colon damage via inhibiting the p38/MAPKAPK2 and PI3K/Akt/GSK3beta/NF-kappaB signalling axes and enhancing splenic Tregs in DSS-induced murine chronic colitis.	Rutin	0-5	glycogen synthase kinase 3 alpha	Mus musculus	97-105
34582634-0	2022	The antioxidant Rutin counteracts the pathological impact of alpha-synuclein on the enteric nervous system in vitro.	Rutin	16-21	synuclein alpha	Homo sapiens	61-76
34582634-6	2022	Our results demonstrated that Rutin inhibited the neurotoxicity induced by A53T alpha-synuclein (Syn) administration by decreasing oxidized lipids and increasing cell viability in both, mesencephalic and enteric cells.	Rutin	30-35	synuclein alpha	Homo sapiens	80-95
34582634-6	2022	Our results demonstrated that Rutin inhibited the neurotoxicity induced by A53T alpha-synuclein (Syn) administration by decreasing oxidized lipids and increasing cell viability in both, mesencephalic and enteric cells.	Rutin	30-35	synemin	Homo sapiens	97-100
34550907-0	2021	Rutin inhibited the advanced glycation end products-stimulated inflammatory response and extra-cellular matrix degeneration via targeting TRAF-6 and BCL-2 proteins in mouse model of osteoarthritis.	Rutin	0-5	TNF receptor-associated factor 6	Mus musculus	138-144
34550907-0	2021	Rutin inhibited the advanced glycation end products-stimulated inflammatory response and extra-cellular matrix degeneration via targeting TRAF-6 and BCL-2 proteins in mouse model of osteoarthritis.	Rutin	0-5	B cell leukemia/lymphoma 2	Mus musculus	149-154
34302158-0	2021	Rutin prevents inflammation-associated colon damage via inhibiting the p38/MAPKAPK2 and PI3K/Akt/GSK3beta/NF-kappaB signalling axes and enhancing splenic Tregs in DSS-induced murine chronic colitis.	Rutin	0-5	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	106-115
34302158-5	2021	The analysis of signalling pathways demonstrated the robust activation of PI3K/Akt/GSK3beta/MAPKs/NF-kappaB and p38/MK2 in DSS-induced colitis in animals, which was efficiently alleviated following the rutin treatment.	Rutin	202-207	thymoma viral proto-oncogene 1	Mus musculus	79-82
34302158-5	2021	The analysis of signalling pathways demonstrated the robust activation of PI3K/Akt/GSK3beta/MAPKs/NF-kappaB and p38/MK2 in DSS-induced colitis in animals, which was efficiently alleviated following the rutin treatment.	Rutin	202-207	glycogen synthase kinase 3 alpha	Mus musculus	83-91
34302158-5	2021	The analysis of signalling pathways demonstrated the robust activation of PI3K/Akt/GSK3beta/MAPKs/NF-kappaB and p38/MK2 in DSS-induced colitis in animals, which was efficiently alleviated following the rutin treatment.	Rutin	202-207	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-107
34302158-5	2021	The analysis of signalling pathways demonstrated the robust activation of PI3K/Akt/GSK3beta/MAPKs/NF-kappaB and p38/MK2 in DSS-induced colitis in animals, which was efficiently alleviated following the rutin treatment.	Rutin	202-207	mitogen-activated protein kinase 14	Mus musculus	112-115
34302158-5	2021	The analysis of signalling pathways demonstrated the robust activation of PI3K/Akt/GSK3beta/MAPKs/NF-kappaB and p38/MK2 in DSS-induced colitis in animals, which was efficiently alleviated following the rutin treatment.	Rutin	202-207	MAP kinase-activated protein kinase 2	Mus musculus	116-119
34302158-11	2021	Overall, results indicate that the modulation of p38/MK2 and PI3K/Akt/GSK3beta/NF-kappaB pathways by rutin represents a novel therapeutic approach in chronic colitis that help to curb dysregulated intestinal integrity, cytokine ratio and splenic Tregs.	Rutin	101-106	mitogen-activated protein kinase 14	Mus musculus	49-52
34302158-11	2021	Overall, results indicate that the modulation of p38/MK2 and PI3K/Akt/GSK3beta/NF-kappaB pathways by rutin represents a novel therapeutic approach in chronic colitis that help to curb dysregulated intestinal integrity, cytokine ratio and splenic Tregs.	Rutin	101-106	MAP kinase-activated protein kinase 2	Mus musculus	53-56
34302158-11	2021	Overall, results indicate that the modulation of p38/MK2 and PI3K/Akt/GSK3beta/NF-kappaB pathways by rutin represents a novel therapeutic approach in chronic colitis that help to curb dysregulated intestinal integrity, cytokine ratio and splenic Tregs.	Rutin	101-106	thymoma viral proto-oncogene 1	Mus musculus	66-69
34302158-11	2021	Overall, results indicate that the modulation of p38/MK2 and PI3K/Akt/GSK3beta/NF-kappaB pathways by rutin represents a novel therapeutic approach in chronic colitis that help to curb dysregulated intestinal integrity, cytokine ratio and splenic Tregs.	Rutin	101-106	glycogen synthase kinase 3 alpha	Mus musculus	70-78
34302158-11	2021	Overall, results indicate that the modulation of p38/MK2 and PI3K/Akt/GSK3beta/NF-kappaB pathways by rutin represents a novel therapeutic approach in chronic colitis that help to curb dysregulated intestinal integrity, cytokine ratio and splenic Tregs.	Rutin	101-106	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	79-88
34577000-0	2021	A Novel Approach to Unraveling the Apoptotic Potential of Rutin (Bioflavonoid) via Targeting Jab1 in Cervical Cancer Cells.	Rutin	58-63	COP9 signalosome subunit 5	Homo sapiens	93-97
34577000-8	2021	Further apoptosis induction, caspase activation, and ROS generation in rutin-treated SiHa cancer cells explain the cascade of events associated with Jab1 downregulation in SiHa cancer cells.	Rutin	71-76	COP9 signalosome subunit 5	Homo sapiens	149-153
34512168-0	2021	Rutin attenuates Sorafenib-induced Chemoresistance and Autophagy in Hepatocellular Carcinoma by regulating BANCR/miRNA-590-5P/OLR1 Axis.	Rutin	0-5	BRAF-activated non-protein coding RNA	Homo sapiens	107-112
34455930-8	2021	From our dynamic binding free energy calculations using MM/PBSA, asiaticoside, betulinic acid, centellasapogenol, methyl brahmate, and rutin exceeded at least one of the binding energies of the reference compounds, which highlights their strong affinity towards SGLT-2.	Rutin	135-140	solute carrier family 5 member 2	Homo sapiens	262-268
34484407-5	2021	Furthermore, rutin alone or in combination with other therapeutic agents has been shown to regulate several signalling pathways involving the Ras/Raf and PI3K/Akt, MAPK, and TGF-beta2/Smad2/3Akt/PTEN, etc., which are related to the processes of carcinogenesis and induction of apoptosis.	Rutin	13-18	AKT serine/threonine kinase 1	Homo sapiens	159-162
34484407-5	2021	Furthermore, rutin alone or in combination with other therapeutic agents has been shown to regulate several signalling pathways involving the Ras/Raf and PI3K/Akt, MAPK, and TGF-beta2/Smad2/3Akt/PTEN, etc., which are related to the processes of carcinogenesis and induction of apoptosis.	Rutin	13-18	transforming growth factor beta 2	Homo sapiens	174-183
34484407-5	2021	Furthermore, rutin alone or in combination with other therapeutic agents has been shown to regulate several signalling pathways involving the Ras/Raf and PI3K/Akt, MAPK, and TGF-beta2/Smad2/3Akt/PTEN, etc., which are related to the processes of carcinogenesis and induction of apoptosis.	Rutin	13-18	SMAD family member 2	Homo sapiens	184-194
34484407-5	2021	Furthermore, rutin alone or in combination with other therapeutic agents has been shown to regulate several signalling pathways involving the Ras/Raf and PI3K/Akt, MAPK, and TGF-beta2/Smad2/3Akt/PTEN, etc., which are related to the processes of carcinogenesis and induction of apoptosis.	Rutin	13-18	phosphatase and tensin homolog	Homo sapiens	195-199
34512168-0	2021	Rutin attenuates Sorafenib-induced Chemoresistance and Autophagy in Hepatocellular Carcinoma by regulating BANCR/miRNA-590-5P/OLR1 Axis.	Rutin	0-5	oxidized low density lipoprotein receptor 1	Homo sapiens	126-130
34512168-7	2021	Our results indicated that rutin treatment attenuates autophagy and BANCR expression in SO resistance cells.	Rutin	27-32	BRAF-activated non-protein coding RNA	Homo sapiens	68-73
34512168-11	2021	Furthermore, in vivo study demonstrated that rutin could inhibit autophagy through the BANCR/miRNA-590-5P/OLR1 axis.	Rutin	45-50	BRAF-activated non-protein coding RNA	Homo sapiens	87-92
34512168-11	2021	Furthermore, in vivo study demonstrated that rutin could inhibit autophagy through the BANCR/miRNA-590-5P/OLR1 axis.	Rutin	45-50	oxidized low density lipoprotein receptor 1	Homo sapiens	106-110
34512168-12	2021	Our findings suggest that rutin could regulate autophagy by regulating BANCR/miRNA-590-5P/OLR1 axis.	Rutin	26-31	BRAF-activated non-protein coding RNA	Homo sapiens	71-76
34512168-12	2021	Our findings suggest that rutin could regulate autophagy by regulating BANCR/miRNA-590-5P/OLR1 axis.	Rutin	26-31	oxidized low density lipoprotein receptor 1	Homo sapiens	90-94
34156073-9	2021	Rutin treatment resulted in a significant reduction in hepatic ferritin protein expression and serum transferrin saturation.	Rutin	0-5	transferrin	Mus musculus	101-112
34456739-0	2021	Rutin, A Natural Inhibitor of IGPD Protein, Partially Inhibits Biofilm Formation in Staphylococcus xylosus ATCC700404 in vitro and in vivo.	Rutin	0-5	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	30-34
34456739-3	2021	Here, we confirmed that rutin can effectively inhibit biofilm formation in S. xylosus, of which the inhibition mechanism involves its ability to interact with imidazole glycerol phosphate dehydratase (IGPD), a key enzyme in the process of biofilm formation.	Rutin	24-29	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	159-199
34456739-3	2021	Here, we confirmed that rutin can effectively inhibit biofilm formation in S. xylosus, of which the inhibition mechanism involves its ability to interact with imidazole glycerol phosphate dehydratase (IGPD), a key enzyme in the process of biofilm formation.	Rutin	24-29	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	201-205
34456739-7	2021	Meanwhile, the results from molecular dynamic simulation and Bio-layer interferometry (BLI) technique showed that rutin could bind to IGPD strongly.	Rutin	114-119	imidazoleglycerol-phosphate dehydratase HisB	Staphylococcus xylosus	134-138
34439096-0	2021	Bacitracin and Rutin Regulate Tissue Factor Production in Inflammatory Monocytes and Acute Myeloid Leukemia Blasts.	Rutin	15-20	coagulation factor III, tissue factor	Homo sapiens	30-43
34440505-0	2021	Rutin Mediated Apoptotic Cell Death in Caski Cervical Cancer Cells via Notch-1 and Hes-1 Downregulation.	Rutin	0-5	notch receptor 1	Homo sapiens	71-78
34440505-0	2021	Rutin Mediated Apoptotic Cell Death in Caski Cervical Cancer Cells via Notch-1 and Hes-1 Downregulation.	Rutin	0-5	hes family bHLH transcription factor 1	Homo sapiens	83-88
34440505-4	2021	Therefore, in this study, we performed several in vitro assays to gain detailed insight about the apoptotic inducing effect of rutin as well as its modulatory effect on Notch-1 and Hes-1 in cervical cancer cells.	Rutin	127-132	notch receptor 1	Homo sapiens	169-176
34440505-4	2021	Therefore, in this study, we performed several in vitro assays to gain detailed insight about the apoptotic inducing effect of rutin as well as its modulatory effect on Notch-1 and Hes-1 in cervical cancer cells.	Rutin	127-132	hes family bHLH transcription factor 1	Homo sapiens	181-186
34440505-6	2021	DAPI and Mitotracker red staining revealed that rutin induced significant apoptotic effects via caspase-3/9 activation, ROS generation, and alteration in Bax/Bcl2 mRNA expression.	Rutin	48-53	caspase 3	Homo sapiens	96-107
34440505-6	2021	DAPI and Mitotracker red staining revealed that rutin induced significant apoptotic effects via caspase-3/9 activation, ROS generation, and alteration in Bax/Bcl2 mRNA expression.	Rutin	48-53	BCL2 associated X, apoptosis regulator	Homo sapiens	154-157
34440505-6	2021	DAPI and Mitotracker red staining revealed that rutin induced significant apoptotic effects via caspase-3/9 activation, ROS generation, and alteration in Bax/Bcl2 mRNA expression.	Rutin	48-53	BCL2 apoptosis regulator	Homo sapiens	158-162
34440505-8	2021	The gene expression analysis further revealed that rutin treatment decreases Notch-1 and Hes-1 mRNA expression.	Rutin	51-56	notch receptor 1	Homo sapiens	77-84
34440505-8	2021	The gene expression analysis further revealed that rutin treatment decreases Notch-1 and Hes-1 mRNA expression.	Rutin	51-56	hes family bHLH transcription factor 1	Homo sapiens	89-94
34440505-9	2021	Altogether, these results showed that rutin showed potent anticancer effects in human cervical cancer Caski cells by triggering apoptosis, G0/G1 phase arrest, and downregulating the level of Notch-1 and Hes-1 of the Notch signaling pathway.	Rutin	38-43	notch receptor 1	Homo sapiens	191-198
34440505-9	2021	Altogether, these results showed that rutin showed potent anticancer effects in human cervical cancer Caski cells by triggering apoptosis, G0/G1 phase arrest, and downregulating the level of Notch-1 and Hes-1 of the Notch signaling pathway.	Rutin	38-43	hes family bHLH transcription factor 1	Homo sapiens	203-208
34440505-9	2021	Altogether, these results showed that rutin showed potent anticancer effects in human cervical cancer Caski cells by triggering apoptosis, G0/G1 phase arrest, and downregulating the level of Notch-1 and Hes-1 of the Notch signaling pathway.	Rutin	38-43	notch receptor 1	Homo sapiens	216-221
34109976-5	2021	This research addresses the growth inhibitory efficacy of rutin against E6 and E7 oncoprotein in HeLa cells, which is known to inactivate several tumor suppressor protein such as p53 and pRB.	Rutin	58-63	tumor protein p53	Homo sapiens	179-182
34358312-11	2021	Rutin co-administration also caused a significant (P < 0.001) increase in tumor necrosis factor-alpha, interleukin-6, and immunoglobulin M levels, while interleukin-1beta and immunoglobulin G decreased significantly (P < 0.001) compared with parasitized control.	Rutin	0-5	tumor necrosis factor	Mus musculus	74-101
34358312-11	2021	Rutin co-administration also caused a significant (P < 0.001) increase in tumor necrosis factor-alpha, interleukin-6, and immunoglobulin M levels, while interleukin-1beta and immunoglobulin G decreased significantly (P < 0.001) compared with parasitized control.	Rutin	0-5	interleukin 6	Mus musculus	103-116
34358312-11	2021	Rutin co-administration also caused a significant (P < 0.001) increase in tumor necrosis factor-alpha, interleukin-6, and immunoglobulin M levels, while interleukin-1beta and immunoglobulin G decreased significantly (P < 0.001) compared with parasitized control.	Rutin	0-5	interleukin 1 beta	Mus musculus	153-170
34109976-5	2021	This research addresses the growth inhibitory efficacy of rutin against E6 and E7 oncoprotein in HeLa cells, which is known to inactivate several tumor suppressor protein such as p53 and pRB.	Rutin	58-63	RB transcriptional corepressor 1	Homo sapiens	187-190
34109976-7	2021	Additionally rutin treatment has also led to downregulation of E6 and E7 expression associated with an increased expression of p53 and pRB levels.	Rutin	13-18	tumor protein p53	Homo sapiens	127-130
34109976-7	2021	Additionally rutin treatment has also led to downregulation of E6 and E7 expression associated with an increased expression of p53 and pRB levels.	Rutin	13-18	RB transcriptional corepressor 1	Homo sapiens	135-138
34205604-6	2021	The immunofluorescence study revealed that R and Q increased the LDLR expression, while only Q improved LDL-C uptake in HepG2 cells.	Rutin	43-44	low density lipoprotein receptor	Homo sapiens	65-69
34116706-6	2021	The effect of rutin on tau oligomer-mediated the production of IL-1beta and TNF-alpha in vitro was measured by ELISA.	Rutin	14-19	interleukin 1 alpha	Mus musculus	63-71
34116706-6	2021	The effect of rutin on tau oligomer-mediated the production of IL-1beta and TNF-alpha in vitro was measured by ELISA.	Rutin	14-19	tumor necrosis factor	Mus musculus	76-85
35492613-8	2022	Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cTNT decreased, while interleukin-10 (IL-10) increased with rutin pretreatment.	Rutin	143-148	tumor necrosis factor	Mus musculus	16-43
34124477-10	2021	Combined treatment of HU with rutin and gallic acid reduced serum levels of both IL-6 and IL-17A.	Rutin	30-35	interleukin 6	Rattus norvegicus	81-85
34124477-10	2021	Combined treatment of HU with rutin and gallic acid reduced serum levels of both IL-6 and IL-17A.	Rutin	30-35	interleukin 17A	Rattus norvegicus	90-96
35509154-0	2022	Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP.	Rutin	23-28	fatty acid binding protein 3	Rattus norvegicus	107-112
35509154-0	2022	Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP.	Rutin	23-28	myosin light chain 3	Rattus norvegicus	114-118
35509154-0	2022	Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP.	Rutin	23-28	natriuretic peptide A	Rattus norvegicus	124-127
35509154-4	2022	Rutin significantly attenuated diclofenac-induced alterations in the serum cardiac markers (LDH, CK-MB, and SGOT), serum cytokine levels (TNF-alpha and IL-6), and oxidative stress markers (MDA and GSH) in the cardiac tissue.	Rutin	0-5	tumor necrosis factor	Rattus norvegicus	138-147
35509154-4	2022	Rutin significantly attenuated diclofenac-induced alterations in the serum cardiac markers (LDH, CK-MB, and SGOT), serum cytokine levels (TNF-alpha and IL-6), and oxidative stress markers (MDA and GSH) in the cardiac tissue.	Rutin	0-5	interleukin 6	Rattus norvegicus	152-156
35430070-5	2022	In addition, pretreatment with two AK inhibitors, rutin and quercetin, significantly decreased the lifespan of beetles treated with deltamethrin.	Rutin	50-55	arginine kinase	Tribolium castaneum	35-37
35233172-4	2022	Based on binding affinity, dynamics behavior, and binding free energies, the present study identifies pentaoxahexacyclo-dotriacontanonaen-trihydroxybenzoate derivative (PDT), rutin, and dihyroxy-oxan-phenyl-chromen-4-one derivative (DOC), luteolin-7-glucoside-4"-neohesperidoside as promising inhibitors of SARS-CoV-2 Mpro and PLpro, respectively.	Rutin	175-180	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	318-322
35233172-4	2022	Based on binding affinity, dynamics behavior, and binding free energies, the present study identifies pentaoxahexacyclo-dotriacontanonaen-trihydroxybenzoate derivative (PDT), rutin, and dihyroxy-oxan-phenyl-chromen-4-one derivative (DOC), luteolin-7-glucoside-4"-neohesperidoside as promising inhibitors of SARS-CoV-2 Mpro and PLpro, respectively.	Rutin	175-180	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	327-332
34065710-5	2021	As a result, anthraquinone (AQ) and rutin were discovered to be new OR6M1 ligands.	Rutin	36-41	olfactory receptor family 6 subfamily M member 1	Homo sapiens	68-73
34065710-6	2021	Based on calcium imaging in OR6M1-expressing Hana3A cells, AQ and rutin were classified as an OR6M1 agonist and antagonist, respectively.	Rutin	66-71	olfactory receptor family 6 subfamily M member 1	Homo sapiens	28-33
34065710-6	2021	Based on calcium imaging in OR6M1-expressing Hana3A cells, AQ and rutin were classified as an OR6M1 agonist and antagonist, respectively.	Rutin	66-71	olfactory receptor family 6 subfamily M member 1	Homo sapiens	94-99
34064664-0	2021	Rutin Modulates MAPK Pathway Differently from Quercetin in Angiotensin II-Induced H9c2 Cardiomyocyte Hypertrophy.	Rutin	0-5	angiotensinogen	Rattus norvegicus	59-73
34064664-7	2021	Exposure to Ang II increased cell surface area, intracellular superoxide anion level, NADPH oxidase and inducible nitric oxide synthase activities, and reduced cellular superoxide dismutase activity and nitrite level, which were similarly reversed by both rutin and quercetin.	Rutin	256-261	angiotensinogen	Rattus norvegicus	12-18
34064664-8	2021	Rutin had no significant effects on phosphorylated proteins of extracellular signal-related kinases (ERK1/2) and p38 but downregulated phosphorylated c-Jun N-terminal kinases (JNK1/2), which were induced by Ang II.	Rutin	0-5	angiotensinogen	Rattus norvegicus	207-213
34393433-2	2021	Hence, we report the binding features of rutin, Luteolin, Salvianolic acid A, Rosmarinic acid and p-Coumaric acid with the target protein SARS-CoV-2 linked RNA dependent RNA polymerase (RdRp) for further consideration.	Rutin	41-46	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	186-190
35483282-7	2022	Catechin, epicatechin, rutin, ferulic acid, and kaempferitrin with high affinity capacity indicated strong inhibiting effect on alpha-glucosidase and alpha-amylase.	Rutin	23-28	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
35431327-3	2022	Molecular docking results demonstrated that the three top docked compounds formed relatively stable complexes within the active site and displayed remarkable binding energy in the order of Tangshenoside III, Rutin and Hesperidin (-9.35, -9.14 and -8.57 kcal/mol, respectively) with Mpro and Rutin, Tangshenoside III and Hesperidin (-9.07, -7.71 and -7.57 kcal/mol) with RBD of SGP.	Rutin	208-213	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	282-286
35431327-3	2022	Molecular docking results demonstrated that the three top docked compounds formed relatively stable complexes within the active site and displayed remarkable binding energy in the order of Tangshenoside III, Rutin and Hesperidin (-9.35, -9.14 and -8.57 kcal/mol, respectively) with Mpro and Rutin, Tangshenoside III and Hesperidin (-9.07, -7.71 and -7.57 kcal/mol) with RBD of SGP.	Rutin	291-296	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	282-286
35469838-9	2022	Furthermore, rutin treatment also attenuated the genomic expression of oxidative markers (nrf2, hmox1a, sod1, and gpx) and inflammatory genes (il6, tnfa, il10, and irf2a) related to ICH.	Rutin	13-18	nfe2 like bZIP transcription factor 2a	Danio rerio	90-94
35469838-9	2022	Furthermore, rutin treatment also attenuated the genomic expression of oxidative markers (nrf2, hmox1a, sod1, and gpx) and inflammatory genes (il6, tnfa, il10, and irf2a) related to ICH.	Rutin	13-18	heme oxygenase 1a	Danio rerio	96-102
35469838-9	2022	Furthermore, rutin treatment also attenuated the genomic expression of oxidative markers (nrf2, hmox1a, sod1, and gpx) and inflammatory genes (il6, tnfa, il10, and irf2a) related to ICH.	Rutin	13-18	superoxide dismutase 1, soluble	Danio rerio	104-108
35469838-9	2022	Furthermore, rutin treatment also attenuated the genomic expression of oxidative markers (nrf2, hmox1a, sod1, and gpx) and inflammatory genes (il6, tnfa, il10, and irf2a) related to ICH.	Rutin	13-18	interleukin 6 (interferon, beta 2)	Danio rerio	143-146
35469838-9	2022	Furthermore, rutin treatment also attenuated the genomic expression of oxidative markers (nrf2, hmox1a, sod1, and gpx) and inflammatory genes (il6, tnfa, il10, and irf2a) related to ICH.	Rutin	13-18	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	148-152
35469838-9	2022	Furthermore, rutin treatment also attenuated the genomic expression of oxidative markers (nrf2, hmox1a, sod1, and gpx) and inflammatory genes (il6, tnfa, il10, and irf2a) related to ICH.	Rutin	13-18	interleukin 10	Danio rerio	154-158
35469838-9	2022	Furthermore, rutin treatment also attenuated the genomic expression of oxidative markers (nrf2, hmox1a, sod1, and gpx) and inflammatory genes (il6, tnfa, il10, and irf2a) related to ICH.	Rutin	13-18	interferon regulatory factor 2a	Danio rerio	164-169
35469838-10	2022	The Gsk-3beta activity was also downregulated, and a normal pool of beta-catenin and Nrf2 was maintained in the larvae treated with rutin.	Rutin	132-137	glycogen synthase kinase 3 alpha b	Danio rerio	4-13
35469838-10	2022	The Gsk-3beta activity was also downregulated, and a normal pool of beta-catenin and Nrf2 was maintained in the larvae treated with rutin.	Rutin	132-137	catenin (cadherin-associated protein), beta 1	Danio rerio	68-80
35469838-10	2022	The Gsk-3beta activity was also downregulated, and a normal pool of beta-catenin and Nrf2 was maintained in the larvae treated with rutin.	Rutin	132-137	nfe2 like bZIP transcription factor 2a	Danio rerio	85-89
35364308-6	2022	Our obtained result demonstrate that Hesperidin, rutin, diosmin, and apiin are most effective compounds agents against SARS-CoV-2 Mpro as compared to Nelfinavir (positive control).	Rutin	49-54	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	130-134
35588172-0	2022	Rutin Inhibits the Progression of Osteoarthritis Through CBS-Mediated RhoA/ROCK Signaling.	Rutin	0-5	cystathionine beta synthase	Rattus norvegicus	57-60
35588172-0	2022	Rutin Inhibits the Progression of Osteoarthritis Through CBS-Mediated RhoA/ROCK Signaling.	Rutin	0-5	ras homolog family member A	Rattus norvegicus	70-74
35588172-6	2022	We found that rutin effectively reduced the expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and matrix metalloproteinase 13 (MMP-13) and increased the expression of Col II and aggrecan (p < 0.001).	Rutin	14-19	nitric oxide synthase 2	Rattus norvegicus	65-96
35588172-6	2022	We found that rutin effectively reduced the expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and matrix metalloproteinase 13 (MMP-13) and increased the expression of Col II and aggrecan (p < 0.001).	Rutin	14-19	nitric oxide synthase 2	Rattus norvegicus	98-102
35588172-6	2022	We found that rutin effectively reduced the expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and matrix metalloproteinase 13 (MMP-13) and increased the expression of Col II and aggrecan (p < 0.001).	Rutin	14-19	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	105-121
35588172-6	2022	We found that rutin effectively reduced the expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and matrix metalloproteinase 13 (MMP-13) and increased the expression of Col II and aggrecan (p < 0.001).	Rutin	14-19	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	123-128
35588172-6	2022	We found that rutin effectively reduced the expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and matrix metalloproteinase 13 (MMP-13) and increased the expression of Col II and aggrecan (p < 0.001).	Rutin	14-19	tumor necrosis factor	Rattus norvegicus	131-158
35588172-6	2022	We found that rutin effectively reduced the expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and matrix metalloproteinase 13 (MMP-13) and increased the expression of Col II and aggrecan (p < 0.001).	Rutin	14-19	tumor necrosis factor	Rattus norvegicus	160-169
35588172-6	2022	We found that rutin effectively reduced the expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and matrix metalloproteinase 13 (MMP-13) and increased the expression of Col II and aggrecan (p < 0.001).	Rutin	14-19	matrix metallopeptidase 13	Rattus norvegicus	176-203
35588172-6	2022	We found that rutin effectively reduced the expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and matrix metalloproteinase 13 (MMP-13) and increased the expression of Col II and aggrecan (p < 0.001).	Rutin	14-19	matrix metallopeptidase 13	Rattus norvegicus	205-211
35588172-8	2022	We concluded that rutin inhibits the inflammatory progression of OA through the CBS-mediated RhoA/ROCK signaling pathway.	Rutin	18-23	cystathionine beta synthase	Rattus norvegicus	80-83
35588172-8	2022	We concluded that rutin inhibits the inflammatory progression of OA through the CBS-mediated RhoA/ROCK signaling pathway.	Rutin	18-23	ras homolog family member A	Rattus norvegicus	93-97
35227839-3	2022	Therefore in this study inclusion complexes of Q and R with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) were formulated to improve the aqueous solubility, antiproliferative efficacy and also antioxidant activity of the flavonoids.	Rutin	53-54	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	96-103
35445769-5	2022	Moreover, rutin also increased the expression of uncoupling protein 1 (Ucp1) and other thermogenic genes and proteins in BAT and inguinal WAT (IWAT), indicating that rutin activated BAT and induced browning of IWAT.	Rutin	10-15	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	49-69
35445769-5	2022	Moreover, rutin also increased the expression of uncoupling protein 1 (Ucp1) and other thermogenic genes and proteins in BAT and inguinal WAT (IWAT), indicating that rutin activated BAT and induced browning of IWAT.	Rutin	10-15	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	71-75
35445769-5	2022	Moreover, rutin also increased the expression of uncoupling protein 1 (Ucp1) and other thermogenic genes and proteins in BAT and inguinal WAT (IWAT), indicating that rutin activated BAT and induced browning of IWAT.	Rutin	166-171	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	49-69
35445769-5	2022	Moreover, rutin also increased the expression of uncoupling protein 1 (Ucp1) and other thermogenic genes and proteins in BAT and inguinal WAT (IWAT), indicating that rutin activated BAT and induced browning of IWAT.	Rutin	166-171	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	71-75
35445769-6	2022	Importantly, rutin markedly enhanced the concentration of SCFAs (acetate, propionate and butyrate) and SCFA-producing enzymes (acetate kinase (ACK), methylmalonyl-CoA decarboxylase (MMD) and butyryl-CoA (BUT)) in feces of db/db mice.	Rutin	13-18	enoyl Coenzyme A hydratase domain containing 1	Mus musculus	149-180
35445769-7	2022	In addition, rutin significantly increased the mRNA expression of monocarboxylate transporter 1 (Mct1), catabolic enzyme acyl-CoA medium-chain synthetase 3 (Acsm3), carnitine palmitoyl transferase 1alpha (Cpt-1alpha) and Cpt-1beta genes in BAT and IWAT of db/db mice, which is conducive to inducing adipocyte thermogenesis.	Rutin	13-18	solute carrier family 16 (monocarboxylic acid transporters), member 1	Mus musculus	66-95
35445769-7	2022	In addition, rutin significantly increased the mRNA expression of monocarboxylate transporter 1 (Mct1), catabolic enzyme acyl-CoA medium-chain synthetase 3 (Acsm3), carnitine palmitoyl transferase 1alpha (Cpt-1alpha) and Cpt-1beta genes in BAT and IWAT of db/db mice, which is conducive to inducing adipocyte thermogenesis.	Rutin	13-18	solute carrier family 16 (monocarboxylic acid transporters), member 1	Mus musculus	97-101
35445769-7	2022	In addition, rutin significantly increased the mRNA expression of monocarboxylate transporter 1 (Mct1), catabolic enzyme acyl-CoA medium-chain synthetase 3 (Acsm3), carnitine palmitoyl transferase 1alpha (Cpt-1alpha) and Cpt-1beta genes in BAT and IWAT of db/db mice, which is conducive to inducing adipocyte thermogenesis.	Rutin	13-18	acyl-CoA synthetase medium-chain family member 3	Mus musculus	157-162
35445769-7	2022	In addition, rutin significantly increased the mRNA expression of monocarboxylate transporter 1 (Mct1), catabolic enzyme acyl-CoA medium-chain synthetase 3 (Acsm3), carnitine palmitoyl transferase 1alpha (Cpt-1alpha) and Cpt-1beta genes in BAT and IWAT of db/db mice, which is conducive to inducing adipocyte thermogenesis.	Rutin	13-18	carnitine palmitoyltransferase 1a, liver	Mus musculus	205-215
35445769-7	2022	In addition, rutin significantly increased the mRNA expression of monocarboxylate transporter 1 (Mct1), catabolic enzyme acyl-CoA medium-chain synthetase 3 (Acsm3), carnitine palmitoyl transferase 1alpha (Cpt-1alpha) and Cpt-1beta genes in BAT and IWAT of db/db mice, which is conducive to inducing adipocyte thermogenesis.	Rutin	13-18	carnitine palmitoyltransferase 1a, liver	Mus musculus	221-230
35377153-2	2022	The finding that quercetin-3-rutinoside inhibits protein disulfide isomerase (PDI) and potently blocks thrombosis in vivo has enabled the evaluation of PDI inhibition in multiple animal models of thrombus formation and has prompted clinical studies of PDI inhibition in thrombosis.	Rutin	17-39	prolyl 4-hydroxylase subunit beta	Homo sapiens	49-76
35377153-2	2022	The finding that quercetin-3-rutinoside inhibits protein disulfide isomerase (PDI) and potently blocks thrombosis in vivo has enabled the evaluation of PDI inhibition in multiple animal models of thrombus formation and has prompted clinical studies of PDI inhibition in thrombosis.	Rutin	17-39	prolyl 4-hydroxylase subunit beta	Homo sapiens	78-81
35377153-3	2022	Nonetheless, how quercetin-3-rutinoside blocks PDI activity remains an unanswered question.	Rutin	17-39	prolyl 4-hydroxylase subunit beta	Homo sapiens	47-50
35377153-4	2022	Combining NMR spectroscopy, site-directed mutagenesis, and biological assays, we identified H256 as the key residue for PDI interacting with quercetin-3-rutinoside.	Rutin	141-163	prolyl 4-hydroxylase subunit beta	Homo sapiens	120-123
35377153-5	2022	Quercetin-3-rutinoside inhibited the activity of PDI (WT) but not PDI (H256A).	Rutin	0-22	prolyl 4-hydroxylase subunit beta	Homo sapiens	49-52
35377153-7	2022	Among several quercetin-3-rutinoside analogues tested, only compounds with a phenoxyl group at position 7 showed direct binding to PDI, further supporting our molecular model.	Rutin	14-36	prolyl 4-hydroxylase subunit beta	Homo sapiens	131-134
35377153-8	2022	Studies using purified coagulation factors showed that quercetin-3-rutinoside inhibited the augmenting effects of PDI (WT), but not PDI (H256A), on tissue factor (TF) activity.	Rutin	55-77	prolyl 4-hydroxylase subunit beta	Homo sapiens	114-117
35377153-8	2022	Studies using purified coagulation factors showed that quercetin-3-rutinoside inhibited the augmenting effects of PDI (WT), but not PDI (H256A), on tissue factor (TF) activity.	Rutin	55-77	coagulation factor III, tissue factor	Homo sapiens	148-161
35377153-10	2022	Together, our studies show that residue H256 in PDI and the phenoxyl group at position 7 in quercetin-3-rutinoside are essential for inhibition of PDI by quercetin-3-rutinoside.	Rutin	92-114	prolyl 4-hydroxylase subunit beta	Homo sapiens	147-150
35377153-10	2022	Together, our studies show that residue H256 in PDI and the phenoxyl group at position 7 in quercetin-3-rutinoside are essential for inhibition of PDI by quercetin-3-rutinoside.	Rutin	154-176	prolyl 4-hydroxylase subunit beta	Homo sapiens	48-51
35377153-10	2022	Together, our studies show that residue H256 in PDI and the phenoxyl group at position 7 in quercetin-3-rutinoside are essential for inhibition of PDI by quercetin-3-rutinoside.	Rutin	154-176	prolyl 4-hydroxylase subunit beta	Homo sapiens	147-150
35492613-8	2022	Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cTNT decreased, while interleukin-10 (IL-10) increased with rutin pretreatment.	Rutin	143-148	tumor necrosis factor	Mus musculus	45-54
35492613-8	2022	Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cTNT decreased, while interleukin-10 (IL-10) increased with rutin pretreatment.	Rutin	143-148	interleukin 6	Mus musculus	72-76
35492613-8	2022	Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cTNT decreased, while interleukin-10 (IL-10) increased with rutin pretreatment.	Rutin	143-148	interleukin 10	Mus musculus	105-119
35492613-8	2022	Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cTNT decreased, while interleukin-10 (IL-10) increased with rutin pretreatment.	Rutin	143-148	interleukin 10	Mus musculus	121-126
35254584-0	2022	Berberis lycium fruit extract and its phytoconstituents berberine and rutin mitigate collagen-CFA-induced arthritis (CIA) via improving GSK3beta/STAT/Akt/MAPKs/NF-kappaB signaling axis mediated oxi-inflammation and joint articular damage in murine model.	Rutin	70-75	glycogen synthase kinase 3 alpha	Mus musculus	136-144
35254584-0	2022	Berberis lycium fruit extract and its phytoconstituents berberine and rutin mitigate collagen-CFA-induced arthritis (CIA) via improving GSK3beta/STAT/Akt/MAPKs/NF-kappaB signaling axis mediated oxi-inflammation and joint articular damage in murine model.	Rutin	70-75	thymoma viral proto-oncogene 1	Mus musculus	150-153
35254584-0	2022	Berberis lycium fruit extract and its phytoconstituents berberine and rutin mitigate collagen-CFA-induced arthritis (CIA) via improving GSK3beta/STAT/Akt/MAPKs/NF-kappaB signaling axis mediated oxi-inflammation and joint articular damage in murine model.	Rutin	70-75	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	160-169
35432305-0	2022	Retraction: Podophyllotoxin and Rutin Modulate M1 (iNOS+) Macrophages and Mitigate Lethal Radiation (LR) Induced Inflammatory Responses in Mice.	Rutin	32-37	nitric oxide synthase 2, inducible	Mus musculus	51-55
35408691-13	2022	(4) Conclusions: our findings indicate that rutin plays an important role in anti-pancreatic cancer effects through a rutin-miR-877-3p-Bcl-2 axis and suggests a potential therapeutic strategy for pancreatic cancer.	Rutin	44-49	BCL2 apoptosis regulator	Homo sapiens	135-140
35279519-0	2022	Rutin ameliorates the promotion effect of fine particulate matter on vascular calcification in calcifying vascular cells and ApoE-/- mice.	Rutin	0-5	apolipoprotein E	Mus musculus	125-129
35465159-6	2022	Using the database of FDA approved drugs, we identified four compounds (neomycin, pemetrexed, quercitrin and rutin) that were able to bind to and distort IRE1 RNase cavity.	Rutin	109-114	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	154-158
35352204-6	2022	It was observed that the expressions of NF-kappaB, TNF-alpha, IL-6, JAK2 and STAT3 in the inflammatory pathway increased after VPA administration, while RUT treatment decreased the levels of these markers.	Rutin	153-156	tumor necrosis factor	Rattus norvegicus	51-60
35352204-6	2022	It was observed that the expressions of NF-kappaB, TNF-alpha, IL-6, JAK2 and STAT3 in the inflammatory pathway increased after VPA administration, while RUT treatment decreased the levels of these markers.	Rutin	153-156	interleukin 6	Rattus norvegicus	62-66
35352204-6	2022	It was observed that the expressions of NF-kappaB, TNF-alpha, IL-6, JAK2 and STAT3 in the inflammatory pathway increased after VPA administration, while RUT treatment decreased the levels of these markers.	Rutin	153-156	Janus kinase 2	Rattus norvegicus	68-72
35352204-6	2022	It was observed that the expressions of NF-kappaB, TNF-alpha, IL-6, JAK2 and STAT3 in the inflammatory pathway increased after VPA administration, while RUT treatment decreased the levels of these markers.	Rutin	153-156	signal transducer and activator of transcription 3	Rattus norvegicus	77-82
35279519-10	2022	Furthermore, rutin effectively prevented vascular calcification by regulating the OPG/RANKL pathway.	Rutin	13-18	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	82-85
35279519-10	2022	Furthermore, rutin effectively prevented vascular calcification by regulating the OPG/RANKL pathway.	Rutin	13-18	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	86-91
35219007-0	2022	Quercetin-3-Rutinoside alleviates radiation-induced lung inflammation and fibrosis via regulation of NF-kappaB/TGF-beta1 signaling.	Rutin	0-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
35305353-10	2022	Meanwhile tanshinone IIA, resveratrol, and silibinin inhibited ATM and/or DNA-PK activation and decreased viral proliferation, while rutin and quercetin inhibited ATR activation and promoted viral production.	Rutin	133-138	ATR serine/threonine kinase	Homo sapiens	163-166
35219007-0	2022	Quercetin-3-Rutinoside alleviates radiation-induced lung inflammation and fibrosis via regulation of NF-kappaB/TGF-beta1 signaling.	Rutin	0-22	transforming growth factor, beta 1	Mus musculus	111-120
35219007-17	2022	CONCLUSION: The findings from the current study clearly demonstrate that Q-3-R provides radioprotection to the lungs by regulating NF-kappaB/TGF-beta1 signaling, scavenging free radicals, preventing perivascular infiltration and prolonged inflammatory cascade which could otherwise lead to chronic radiation fibrosis.	Rutin	73-78	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	131-140
35219007-17	2022	CONCLUSION: The findings from the current study clearly demonstrate that Q-3-R provides radioprotection to the lungs by regulating NF-kappaB/TGF-beta1 signaling, scavenging free radicals, preventing perivascular infiltration and prolonged inflammatory cascade which could otherwise lead to chronic radiation fibrosis.	Rutin	73-78	transforming growth factor, beta 1	Mus musculus	141-150
35128266-11	2022	Among the dereplicated compounds, hesperidin, naringin, and rutin have been established as promising inducer compounds for the chemopreventive marker NQO1.	Rutin	60-65	NAD(P)H dehydrogenase, quinone 1	Mus musculus	150-154
3191199-2	1988	Quercetin and rutin were found to inhibit NADPH and CCl4-dependent LPO in rat liver microsomes, however, in the case of CCl4-dependent LPO, rutin had a very poor antioxidant effect.	Rutin	14-19	C-C motif chemokine ligand 4	Rattus norvegicus	52-56
2777309-1	1989	The interaction of native and modified bovine serum albumin (BSA) with catechin, a flavanoid having vitamin P activity, has been studied using equilibrium dialysis, pH-metric, viscosity and spectrophotometric methods.	Rutin	100-109	albumin	Homo sapiens	46-59
35164183-6	2022	The MD simulations indicated the stability of the AT1R:floribundic acid, amyloid beta:rutin, and tau:brassicasterol systems.	Rutin	86-91	amyloid beta precursor protein	Homo sapiens	73-85
35056677-3	2022	Furthermore, the phenol composition analysis showed the presence of p-Coumaric acid (196.88 mg /mL) and rutin (312.9 mg /mL), which were used for the in vitro extraction and determination of the antioxidant activity.	Rutin	104-109	thrombopoietin	Mus musculus	121-123
35057010-7	2022	Luteolin and rutin inhibit NFkappaB activation, reducing IL-6 production.	Rutin	13-18	interleukin 6	Homo sapiens	57-61
35057010-10	2022	Apigenin and rutin induce apoptosis in C6 cells increasing TNFalpha, while decreasing IL-10 production, denoting a shift from the immunosuppressive Th2 to the Th1 profile.	Rutin	13-18	tumor necrosis factor	Homo sapiens	59-67
35057010-10	2022	Apigenin and rutin induce apoptosis in C6 cells increasing TNFalpha, while decreasing IL-10 production, denoting a shift from the immunosuppressive Th2 to the Th1 profile.	Rutin	13-18	interleukin 10	Homo sapiens	86-91
35253634-6	2022	RESULTS: It was observed that procyanidin and amentoflavone could bind to the GSK-3beta active sites at the picomolar (pM) scale as well as the binding affinity of DeltaG binding < -13 kcal/mol, while the inhibition constant for theaflavin 3"-gallate, procyanidin B4, and rutin was calculated at the nanomolar (nM) scale, suggesting that these phenolic compounds can be considered as potential effective GSK-3beta inhibitors.	Rutin	272-277	glycogen synthase kinase 3 alpha	Homo sapiens	78-87
3191199-2	1988	Quercetin and rutin were found to inhibit NADPH and CCl4-dependent LPO in rat liver microsomes, however, in the case of CCl4-dependent LPO, rutin had a very poor antioxidant effect.	Rutin	140-145	C-C motif chemokine ligand 4	Rattus norvegicus	120-124
3746425-3	1986	For example, we have found that 2 chlorine atoms at the C-4 and C-6 positions on the glucopyranoside ring are required for inhibition.	Rutin	85-100	complement C4A (Rodgers blood group)	Homo sapiens	56-59
2968941-1	1988	Flavonoids (quercetin, rutin) influence ATPase activity and actomyosin superprecipitation.	Rutin	23-28	dynein axonemal heavy chain 8	Homo sapiens	40-46
3746425-3	1986	For example, we have found that 2 chlorine atoms at the C-4 and C-6 positions on the glucopyranoside ring are required for inhibition.	Rutin	85-100	complement C6	Homo sapiens	64-67
6574492-9	1983	Thus, the rutin moiety is implicated as exerting a regulatory effect on isotype expression by suppressing the production of serum antibodies of isotypes other than IgE.	Rutin	10-15	immunoglobulin heavy constant epsilon	Homo sapiens	164-167
6891672-4	1982	1%) of purified diets administered to rats for 4 wk, rutin and (+)-catechin increased microsomal cytochrome b5 levels and quercetin and (+)-catechin increased aminopyrine demethylase activity.	Rutin	53-58	cytochrome b5 type A	Rattus norvegicus	97-110
6814912-5	1982	Flavonoids, e.g. quercetin and rutin, inhibit aldose reductase (IC50 = 2 - 5 microM).	Rutin	31-36	aldo-keto reductase family 1 member B	Homo sapiens	46-62
13187441-0	1954	[Activities of vitamin P (rutin) in the presence of vitamin B12 (cyanocobalamin) in some albuminuria].	Rutin	15-24	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	60-63
7332598-0	1981	The beta-glucuronidase catalyzed hydrolysis of a glucopyranosiduronamide and a glucopyranoside: evidence for the oxocarbonium ion mechanism for bovine liver beta-glucuronidase.	Rutin	79-94	beta-glucuronidase	Bos taurus	4-22
7332598-0	1981	The beta-glucuronidase catalyzed hydrolysis of a glucopyranosiduronamide and a glucopyranoside: evidence for the oxocarbonium ion mechanism for bovine liver beta-glucuronidase.	Rutin	79-94	beta-glucuronidase	Bos taurus	157-175
13187441-0	1954	[Activities of vitamin P (rutin) in the presence of vitamin B12 (cyanocobalamin) in some albuminuria].	Rutin	26-31	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	60-63
18113502-0	1949	Effect of vitamin P compounds on the action of histidine decarboxylase.	Rutin	10-19	histidine decarboxylase	Homo sapiens	47-70
33988888-6	2021	Rutin significantly reduced fat accumulation in both fat-6 and fat-7 mutant strains but did not affect the fat storage of fat-6/fat-7 double mutant, which indicated that the impact of rutin on fat storage depended on fat-6 and fat-7.	Rutin	0-5	Delta(9)-fatty-acid desaturase fat-6	Caenorhabditis elegans	53-58
34044723-8	2021	Differential regulations of Bcl2, Bax and NF-kappaB with reduced serum TNF-alpha level indicated anti-apoptotic and anti-inflammatory roles of Q-3-R.	Rutin	143-148	B cell leukemia/lymphoma 2	Mus musculus	28-32
34044723-8	2021	Differential regulations of Bcl2, Bax and NF-kappaB with reduced serum TNF-alpha level indicated anti-apoptotic and anti-inflammatory roles of Q-3-R.	Rutin	143-148	BCL2-associated X protein	Mus musculus	34-37
34044723-8	2021	Differential regulations of Bcl2, Bax and NF-kappaB with reduced serum TNF-alpha level indicated anti-apoptotic and anti-inflammatory roles of Q-3-R.	Rutin	143-148	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	42-51
34044723-8	2021	Differential regulations of Bcl2, Bax and NF-kappaB with reduced serum TNF-alpha level indicated anti-apoptotic and anti-inflammatory roles of Q-3-R.	Rutin	143-148	tumor necrosis factor	Mus musculus	71-80
34044723-12	2021	Q-3-R restored the total leukocyte counts and serum IL-6 levels, further supporting its role in promoting hematopoiesis.	Rutin	0-5	interleukin 6	Mus musculus	52-56
33988888-6	2021	Rutin significantly reduced fat accumulation in both fat-6 and fat-7 mutant strains but did not affect the fat storage of fat-6/fat-7 double mutant, which indicated that the impact of rutin on fat storage depended on fat-6 and fat-7.	Rutin	0-5	Delta(9)-fatty-acid desaturase fat-7	Caenorhabditis elegans	63-68
33978902-0	2021	Inhibition of gammaH2AX, COX-2 and regulation of antioxidant enzymes in MPP+-exposed SH-SY5Y cells pre-treated with rutin.	Rutin	116-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
33978902-0	2021	Inhibition of gammaH2AX, COX-2 and regulation of antioxidant enzymes in MPP+-exposed SH-SY5Y cells pre-treated with rutin.	Rutin	116-121	M-phase phosphoprotein 6	Homo sapiens	72-75
33978902-6	2021	Rutin significantly attenuated MPP+-induced loss of cell viability, mitigated ROS and NO production and inhibited the disruption of antioxidant enzymes activity.	Rutin	0-5	M-phase phosphoprotein 6	Homo sapiens	31-34
33978902-7	2021	It was also observed that rutin significantly reduced protein expression levels of gammaH2AX and COX-2 in SH-SY5Y cells treated with MPP+.	Rutin	26-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
33978902-7	2021	It was also observed that rutin significantly reduced protein expression levels of gammaH2AX and COX-2 in SH-SY5Y cells treated with MPP+.	Rutin	26-31	M-phase phosphoprotein 6	Homo sapiens	133-136
33977682-4	2021	In addition, the inhibitory activities of three phytochemical compounds (Rutin, Gallic acid and Rosmarinic acid) from CVE against Carbonyl reductase 1 (CBR1) were examined.	Rutin	73-78	carbonyl reductase 1	Rattus norvegicus	152-156
33977682-11	2021	From the structural analysis, Rutin and RSA exhibited the highest binding free energies against CBR1, and also exhibited structural stability when bound with CBR1.	Rutin	30-35	carbonyl reductase 1	Rattus norvegicus	96-100
33977682-11	2021	From the structural analysis, Rutin and RSA exhibited the highest binding free energies against CBR1, and also exhibited structural stability when bound with CBR1.	Rutin	30-35	carbonyl reductase 1	Rattus norvegicus	158-162
33978063-0	2021	The effect of mild hypothermia plus rutin on the treatment of spinal cord injury and inflammatory factors by repressing TGF-beta/smad pathway.	Rutin	36-41	transforming growth factor, beta 1	Rattus norvegicus	120-128
33978063-10	2021	CONCLUSIONS: MH+Rutin can suppress the activation of TGF-beta/Smad pathway, hence repressing the cellular inflammatory response after SCI.	Rutin	16-21	transforming growth factor, beta 1	Rattus norvegicus	53-61
33556646-11	2021	Our findings indicate that hypericin possessed inhibition activity, and both rutin and cyanidin-3-O-glucoside resulted in a concentration-dependent inhibition of the PLpro, with activity in the micromolar range.	Rutin	77-82	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	166-171
13603818-0	1958	[Clinical observations on the treatment of glaucoma with vitamin P (citrin)].	Rutin	57-66	solute carrier family 25 member 13	Homo sapiens	68-74
33891955-0	2021	Procyanidin B2 and rutin in Ginkgo biloba extracts protect human retinal pigment epithelial (RPE) cells from oxidative stress by modulating Nrf2 and Erk1/2 signalling.	Rutin	19-24	NFE2 like bZIP transcription factor 2	Homo sapiens	140-144
33740613-0	2021	Rutin, alpha-tocopherol, and l-ascorbic acid up-regulate type I interferon-regulated gene and type I and II interferon expressions and reduce inflammatory cytokine expressions in monocyte-derived macrophages infected with highly pathogenic porcine reproductive and respiratory syndrome virus.	Rutin	0-5	type i interferon-regulated gene and type i and ii interferon	None	57-118
33740613-5	2021	Compared with HP-PRRSV-inoculated MDM, stimulation with rutin, alpha-tocopherol, and l-ascorbic acid, but not beta-carotene significantly enhanced mRNA expression levels of IRF3, IRF7, STING, OPN, IFNalpha, IFNbeta, and IFNgamma in HP-PRRSV-inoculated MDM.	Rutin	56-61	interferon regulatory factor 3	Homo sapiens	173-177
33740613-5	2021	Compared with HP-PRRSV-inoculated MDM, stimulation with rutin, alpha-tocopherol, and l-ascorbic acid, but not beta-carotene significantly enhanced mRNA expression levels of IRF3, IRF7, STING, OPN, IFNalpha, IFNbeta, and IFNgamma in HP-PRRSV-inoculated MDM.	Rutin	56-61	interferon regulatory factor 7	Homo sapiens	179-183
33740613-5	2021	Compared with HP-PRRSV-inoculated MDM, stimulation with rutin, alpha-tocopherol, and l-ascorbic acid, but not beta-carotene significantly enhanced mRNA expression levels of IRF3, IRF7, STING, OPN, IFNalpha, IFNbeta, and IFNgamma in HP-PRRSV-inoculated MDM.	Rutin	56-61	secreted phosphoprotein 1	Homo sapiens	192-195
33740613-5	2021	Compared with HP-PRRSV-inoculated MDM, stimulation with rutin, alpha-tocopherol, and l-ascorbic acid, but not beta-carotene significantly enhanced mRNA expression levels of IRF3, IRF7, STING, OPN, IFNalpha, IFNbeta, and IFNgamma in HP-PRRSV-inoculated MDM.	Rutin	56-61	interferon alpha 1	Homo sapiens	197-205
33740613-5	2021	Compared with HP-PRRSV-inoculated MDM, stimulation with rutin, alpha-tocopherol, and l-ascorbic acid, but not beta-carotene significantly enhanced mRNA expression levels of IRF3, IRF7, STING, OPN, IFNalpha, IFNbeta, and IFNgamma in HP-PRRSV-inoculated MDM.	Rutin	56-61	interferon alpha 1	Homo sapiens	207-214
33740613-5	2021	Compared with HP-PRRSV-inoculated MDM, stimulation with rutin, alpha-tocopherol, and l-ascorbic acid, but not beta-carotene significantly enhanced mRNA expression levels of IRF3, IRF7, STING, OPN, IFNalpha, IFNbeta, and IFNgamma in HP-PRRSV-inoculated MDM.	Rutin	56-61	interferon gamma	Homo sapiens	220-228
33740613-6	2021	Stimulation with rutin also significantly reduced mRNA expression levels of TNFalpha and TGFbeta, whereas stimulation with beta-carotene and alpha-tocopherol significantly reduced TNFalpha mRNA expression in HP-PRRSV-inoculated MDM.	Rutin	17-22	tumor necrosis factor	Homo sapiens	76-84
33740613-6	2021	Stimulation with rutin also significantly reduced mRNA expression levels of TNFalpha and TGFbeta, whereas stimulation with beta-carotene and alpha-tocopherol significantly reduced TNFalpha mRNA expression in HP-PRRSV-inoculated MDM.	Rutin	17-22	transforming growth factor alpha	Homo sapiens	89-96
33740613-7	2021	Our findings demonstrate the potentials of rutin, alpha-tocopherol, and l-ascorbic acid in enhancing type I interferon-regulated genes and type I and II IFN expressions, and in reducing pro- and/or anti-inflammatory cytokine expressions in HP-PRRSV-inoculated MDM.	Rutin	43-48	type i interferon-regulated genes and type i and ii ifn	None	101-156
33844168-10	2022	Rutin increased the activity of the pump in Cd +Pb-treated rats compared to the Cd+Pb group.	Rutin	0-5	serine peptidase inhibitor, Kunitz type, 2	Rattus norvegicus	48-50
33888980-7	2021	The results of molecular docking revealed that Taxol, Rutin, Genkwanine, and Luteolin-glucoside have a high affinity with ACE2 and 3CLpro.	Rutin	54-59	angiotensin converting enzyme 2	Homo sapiens	122-126
33844168-3	2022	This study investigated the effect of rutin on Cd and/or Pb-induced cardiac and erythrocyte disorders in male rats.	Rutin	38-43	serine peptidase inhibitor, Kunitz type, 2	Rattus norvegicus	57-59
33891955-0	2021	Procyanidin B2 and rutin in Ginkgo biloba extracts protect human retinal pigment epithelial (RPE) cells from oxidative stress by modulating Nrf2 and Erk1/2 signalling.	Rutin	19-24	mitogen-activated protein kinase 3	Homo sapiens	149-155
33156389-9	2021	Molecular docking results revealed the higher binding energy of - 150.973 kJ/mol of rutin with EGFR.	Rutin	84-89	epidermal growth factor receptor	Rattus norvegicus	95-99
33715179-8	2021	Eventually, the established method has been applied to screen potential alpha-glucosidase inhibitors from an extract of Lycium barbarum and the peak area of rutin, taxifolin, quercetin and chlorogenic acid in L. barbarum samples changed before and after the enzymatic reaction, confirming that these four compounds had potential inhibitory activities, which was consistent with the literature data.	Rutin	157-162	sucrase-isomaltase	Homo sapiens	72-89
33781184-0	2021	Micro Composite Palmitoylethanolamide/Rutin Reduces Vascular Injury through Modulation of the Nrf2/HO-1 and NF-kB Pathways.	Rutin	38-43	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
33781184-0	2021	Micro Composite Palmitoylethanolamide/Rutin Reduces Vascular Injury through Modulation of the Nrf2/HO-1 and NF-kB Pathways.	Rutin	38-43	heme oxygenase 1	Homo sapiens	99-103
32979714-5	2021	The sensitivity ranking to PPO was: myricetin glycosides > quercetin glycosides > kaempferol glycosides.	Rutin	59-79	protoporphyrinogen oxidase	Homo sapiens	27-30
33668647-4	2021	Gallic acid and rutin were associated with a significantly greater mitochondrial DNA (cytochrome b and COX-II), mitochondrial enzymatic activities (including citrate synthase and cytochrome c oxidase), and intracellular ATP levels in C2C12 myotubes.	Rutin	16-21	mitochondrially encoded cytochrome b	Homo sapiens	86-98
33538615-2	2021	Results: Our findings revealed that the rutin-loaded LCNs inhibited the genes, namely Nox2B and Nox4, which caused oxidative stress.	Rutin	40-45	NADPH oxidase 4	Homo sapiens	96-100
33668647-0	2021	Rutin and Gallic Acid Regulates Mitochondrial Functions via the SIRT1 Pathway in C2C12 Myotubes.	Rutin	0-5	sirtuin 1	Homo sapiens	64-69
33791807-0	2021	Rutin prevents inflammation induced by lipopolysaccharide in RAW 264.7 cells via conquering the TLR4-MyD88-TRAF6-NF-kappaB signalling pathway.	Rutin	0-5	toll-like receptor 4	Mus musculus	96-100
33791807-0	2021	Rutin prevents inflammation induced by lipopolysaccharide in RAW 264.7 cells via conquering the TLR4-MyD88-TRAF6-NF-kappaB signalling pathway.	Rutin	0-5	myeloid differentiation primary response gene 88	Mus musculus	101-106
33791807-0	2021	Rutin prevents inflammation induced by lipopolysaccharide in RAW 264.7 cells via conquering the TLR4-MyD88-TRAF6-NF-kappaB signalling pathway.	Rutin	0-5	TNF receptor-associated factor 6	Mus musculus	107-112
33668647-4	2021	Gallic acid and rutin were associated with a significantly greater mitochondrial DNA (cytochrome b and COX-II), mitochondrial enzymatic activities (including citrate synthase and cytochrome c oxidase), and intracellular ATP levels in C2C12 myotubes.	Rutin	16-21	citrate synthase	Homo sapiens	158-174
33668647-6	2021	Our findings indicated that gallic acid and rutin may have a beneficial effect on mitochondrial dynamics via regulation of the SIRT1-associated pathway in C2C12 myotubes.	Rutin	44-49	sirtuin 1	Homo sapiens	127-132
33717419-0	2021	Rutin inhibits DRP1-mediated mitochondrial fission and prevents ethanol-induced hepatotoxicity in HepG2 cells and zebrafish.	Rutin	0-5	utrophin	Homo sapiens	15-19
33017787-0	2021	Influence of antioxidant flavonoids quercetin and rutin on the in-vitro binding of neratinib to human serum albumin.	Rutin	50-55	albumin	Homo sapiens	102-115
32780460-3	2021	E-DRS scavenged free oxygen radicals effectively, including superoxide anion (ascorbic acid > E-DRS > SAA >= rutin > RES) and DPPH radical (rutin > E-DRS >= ascorbic acid > SAA > RES), and exhibited powerful total antioxidant capacity (ascorbic acid > E-DRS > SAA >= rutin > RES) in vitro.	Rutin	109-114	sushi-repeat-containing protein	Mus musculus	2-5
33017787-1	2021	This study was designed to examine the interaction of neratinib (NRB) with human serum albumin (HSA) in presence of flavonoids quercetin and rutin.	Rutin	141-146	albumin	Homo sapiens	81-94
33017787-1	2021	This study was designed to examine the interaction of neratinib (NRB) with human serum albumin (HSA) in presence of flavonoids quercetin and rutin.	Rutin	141-146	albumin	Homo sapiens	96-99
33017787-2	2021	Both quercetin and rutin can compete with NRB to bind to HSA and displace NRB from its binding site.	Rutin	19-24	albumin	Homo sapiens	57-60
33017787-7	2021	Interaction of NRB with HSA in presence of quercetin and rutin resulted in changes in the binding constants of HSA-NRB suggesting some impact on the binding of NRB in the presence of flavonoids.	Rutin	57-62	albumin	Homo sapiens	24-27
33017787-7	2021	Interaction of NRB with HSA in presence of quercetin and rutin resulted in changes in the binding constants of HSA-NRB suggesting some impact on the binding of NRB in the presence of flavonoids.	Rutin	57-62	albumin	Homo sapiens	111-114
32780460-3	2021	E-DRS scavenged free oxygen radicals effectively, including superoxide anion (ascorbic acid > E-DRS > SAA >= rutin > RES) and DPPH radical (rutin > E-DRS >= ascorbic acid > SAA > RES), and exhibited powerful total antioxidant capacity (ascorbic acid > E-DRS > SAA >= rutin > RES) in vitro.	Rutin	140-145	sushi-repeat-containing protein	Mus musculus	2-5
33492574-9	2021	We showed that rutin inhibited the cell death and loss of glutamine synthetase (GS) induced by glutamate that was associated with an increase in glutamate-aspartate transporter (GLAST) in brain organotypic cultures from post-natal Wistar rats.	Rutin	15-20	glutamate-ammonia ligase	Rattus norvegicus	58-78
33146846-0	2021	Regulation of AKT/AMPK signaling, autophagy and mitigation of apoptosis in Rutin-pretreated SH-SY5Y cells exposed to MPP.	Rutin	75-80	AKT serine/threonine kinase 1	Homo sapiens	14-17
33146846-0	2021	Regulation of AKT/AMPK signaling, autophagy and mitigation of apoptosis in Rutin-pretreated SH-SY5Y cells exposed to MPP.	Rutin	75-80	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	18-22
33146846-4	2021	Results show reduced changes in nuclear morphology and mitigation of caspase 3/7 and 9 activities in rutin pre-treated cells exposed to MPP+.	Rutin	101-106	caspase 3	Homo sapiens	69-86
33146846-6	2021	Also, rutin significantly increased protein expression levels of full-length caspase 3 in SH-SY5Y cells treated with MPP+.	Rutin	6-11	caspase 3	Homo sapiens	77-86
33340613-4	2021	As a proof-of-concept, we selected Pr3+ as the representative to conjugate with rutin to form rutin-Pr(III) complex, which was further applied to interact with HSA in aqueous solution.	Rutin	80-85	proteinase 3	Homo sapiens	35-38
33340613-4	2021	As a proof-of-concept, we selected Pr3+ as the representative to conjugate with rutin to form rutin-Pr(III) complex, which was further applied to interact with HSA in aqueous solution.	Rutin	94-99	proteinase 3	Homo sapiens	35-38
33492574-9	2021	We showed that rutin inhibited the cell death and loss of glutamine synthetase (GS) induced by glutamate that was associated with an increase in glutamate-aspartate transporter (GLAST) in brain organotypic cultures from post-natal Wistar rats.	Rutin	15-20	glutamate-ammonia ligase	Rattus norvegicus	80-82
33492574-9	2021	We showed that rutin inhibited the cell death and loss of glutamine synthetase (GS) induced by glutamate that was associated with an increase in glutamate-aspartate transporter (GLAST) in brain organotypic cultures from post-natal Wistar rats.	Rutin	15-20	solute carrier family 1 member 3	Rattus norvegicus	145-176
33492574-9	2021	We showed that rutin inhibited the cell death and loss of glutamine synthetase (GS) induced by glutamate that was associated with an increase in glutamate-aspartate transporter (GLAST) in brain organotypic cultures from post-natal Wistar rats.	Rutin	15-20	solute carrier family 1 member 3	Rattus norvegicus	178-183
33122058-0	2020	Multi-spectroscopic investigation, molecular docking and molecular dynamic simulation of competitive interactions between flavonoids (quercetin and rutin) and sorafenib for binding to human serum albumin.	Rutin	148-153	albumin	Homo sapiens	190-203
33146673-7	2021	RESULTS: The network pharmacology research showed that TCM could decrease IL-6 using several compounds, such as quercetin, ursolic acid, luteolin, and rutin.	Rutin	151-156	interleukin 6	Homo sapiens	74-78
33146673-11	2021	Quercetin, ursolic acid, luteolin, and rutin could inhibit COVID-19 by downregulating IL-6.	Rutin	39-44	interleukin 6	Homo sapiens	86-90
33466256-9	2021	In addition, extracts from beginning of flowering and end of flowering at a concentration of 25 microg/mL, containing significantly less rutin and rosmarinic acid, in combination with irradiation of cells with UVB, significantly increased the lipid peroxidation process, particularly in melanoma cells.	Rutin	137-142	thrombopoietin	Mus musculus	103-105
32864822-0	2021	Rutin treats myocardial damage caused by pirarubicin via regulating miR-22-5p-regulated RAP1/ERK signaling pathway.	Rutin	0-5	microRNA 22	Rattus norvegicus	68-74
32864822-0	2021	Rutin treats myocardial damage caused by pirarubicin via regulating miR-22-5p-regulated RAP1/ERK signaling pathway.	Rutin	0-5	Eph receptor B1	Rattus norvegicus	93-96
33542917-8	2020	The results are indicative of better potential of solanine, acetoside, and rutin, as Mpro and spike glycoprotein RBD dual inhibitors.	Rutin	75-80	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	85-89
33303988-0	2021	3,4-dihydroxytoluene, a metabolite of rutin, suppresses the progression of nonalcoholic fatty liver disease in mice by inhibiting p300 histone acetyltransferase activity.	Rutin	38-43	E1A binding protein p300	Mus musculus	130-134
33364229-14	2020	Further, our findings indicate that in particular hypericin, rutin, and cyanidin-3-O-glucoside, represent suitable candidates for subsequent evaluation as PLpro inhibitors.	Rutin	61-66	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	155-160
33122058-2	2020	The aim of this study was to evaluate anticancer drug sorafenib displacement from the binding site on human serum albumin by commonly used plant flavonoids quercetin and rutin.	Rutin	170-175	albumin	Homo sapiens	108-121
33140777-6	2020	Using in silico methods (docking and molecular dynamics simulations), we revealed the dynamics and energetics of rutin when interacting with the Mpro of SARS-CoV-2, suggesting that the highly hydrophilic rutin molecule can be bound inside the Mpro"s pocket (active site) and possibly inhibit its biological functions.	Rutin	113-118	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	145-149
33140777-6	2020	Using in silico methods (docking and molecular dynamics simulations), we revealed the dynamics and energetics of rutin when interacting with the Mpro of SARS-CoV-2, suggesting that the highly hydrophilic rutin molecule can be bound inside the Mpro"s pocket (active site) and possibly inhibit its biological functions.	Rutin	113-118	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	243-247
33140777-6	2020	Using in silico methods (docking and molecular dynamics simulations), we revealed the dynamics and energetics of rutin when interacting with the Mpro of SARS-CoV-2, suggesting that the highly hydrophilic rutin molecule can be bound inside the Mpro"s pocket (active site) and possibly inhibit its biological functions.	Rutin	204-209	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	145-149
33140777-6	2020	Using in silico methods (docking and molecular dynamics simulations), we revealed the dynamics and energetics of rutin when interacting with the Mpro of SARS-CoV-2, suggesting that the highly hydrophilic rutin molecule can be bound inside the Mpro"s pocket (active site) and possibly inhibit its biological functions.	Rutin	204-209	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	243-247
33164004-8	2020	Moreover, a CSI-MS method for the rapid screening of IAPP-inhibitors was established and two of the most potential inhibitors (rutin and quercitrin) were screened from a series of flavonoids.	Rutin	127-132	islet amyloid polypeptide	Homo sapiens	53-57
33089540-5	2020	Results revealed significant heightening of arterial pressure and oxidative stress indices, while hypertensive rats treated with rutin had lower expressions of angiotensin converting enzyme (ACE) and mineralocorticoid receptor in uninephrectomized rats.	Rutin	129-134	angiotensin I converting enzyme	Rattus norvegicus	160-189
33089540-5	2020	Results revealed significant heightening of arterial pressure and oxidative stress indices, while hypertensive rats treated with rutin had lower expressions of angiotensin converting enzyme (ACE) and mineralocorticoid receptor in uninephrectomized rats.	Rutin	129-134	angiotensin I converting enzyme	Rattus norvegicus	191-194
33089540-5	2020	Results revealed significant heightening of arterial pressure and oxidative stress indices, while hypertensive rats treated with rutin had lower expressions of angiotensin converting enzyme (ACE) and mineralocorticoid receptor in uninephrectomized rats.	Rutin	129-134	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	200-226
33089540-6	2020	Together, rutin as a novel antihypertensive flavonoid could provide an unimaginable benefits for the management of hypertension through inhibition of angiotensin converting enzyme and mineralocorticoid receptor.	Rutin	10-15	angiotensin I converting enzyme	Rattus norvegicus	150-179
33089540-6	2020	Together, rutin as a novel antihypertensive flavonoid could provide an unimaginable benefits for the management of hypertension through inhibition of angiotensin converting enzyme and mineralocorticoid receptor.	Rutin	10-15	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	184-210
33089540-10	2020	The study revealed that rutin, a known flavonoid inhibited angiotensin converting enzyme (ACE), angiotensin 2 type 1 receptor (ATR1), and mineralocorticoid receptor (MCR), comparable to the classic ACE inhibitor, Lisinopril, indicating the novel antihypertensive property of rutin.	Rutin	24-29	angiotensin I converting enzyme	Rattus norvegicus	59-88
33089540-10	2020	The study revealed that rutin, a known flavonoid inhibited angiotensin converting enzyme (ACE), angiotensin 2 type 1 receptor (ATR1), and mineralocorticoid receptor (MCR), comparable to the classic ACE inhibitor, Lisinopril, indicating the novel antihypertensive property of rutin.	Rutin	24-29	angiotensin I converting enzyme	Rattus norvegicus	90-93
33089540-10	2020	The study revealed that rutin, a known flavonoid inhibited angiotensin converting enzyme (ACE), angiotensin 2 type 1 receptor (ATR1), and mineralocorticoid receptor (MCR), comparable to the classic ACE inhibitor, Lisinopril, indicating the novel antihypertensive property of rutin.	Rutin	24-29	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	138-164
33089540-10	2020	The study revealed that rutin, a known flavonoid inhibited angiotensin converting enzyme (ACE), angiotensin 2 type 1 receptor (ATR1), and mineralocorticoid receptor (MCR), comparable to the classic ACE inhibitor, Lisinopril, indicating the novel antihypertensive property of rutin.	Rutin	24-29	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	166-169
33089540-10	2020	The study revealed that rutin, a known flavonoid inhibited angiotensin converting enzyme (ACE), angiotensin 2 type 1 receptor (ATR1), and mineralocorticoid receptor (MCR), comparable to the classic ACE inhibitor, Lisinopril, indicating the novel antihypertensive property of rutin.	Rutin	24-29	angiotensin I converting enzyme	Rattus norvegicus	198-201
33202817-8	2020	The immunoblotting data indicated that rutin promotes production of antioxidant enzymes induced by nuclear factor erythroid 2-related factor 2 (NRF2), inhibits the expression of matrix metalloproteinases (MMPs) regulated by NF-kappaB, and decreases the expression of vascular endothelial growth factor (VEGF).	Rutin	39-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	99-142
33202817-8	2020	The immunoblotting data indicated that rutin promotes production of antioxidant enzymes induced by nuclear factor erythroid 2-related factor 2 (NRF2), inhibits the expression of matrix metalloproteinases (MMPs) regulated by NF-kappaB, and decreases the expression of vascular endothelial growth factor (VEGF).	Rutin	39-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	144-148
33202817-8	2020	The immunoblotting data indicated that rutin promotes production of antioxidant enzymes induced by nuclear factor erythroid 2-related factor 2 (NRF2), inhibits the expression of matrix metalloproteinases (MMPs) regulated by NF-kappaB, and decreases the expression of vascular endothelial growth factor (VEGF).	Rutin	39-44	vascular endothelial growth factor A	Rattus norvegicus	267-301
33202817-8	2020	The immunoblotting data indicated that rutin promotes production of antioxidant enzymes induced by nuclear factor erythroid 2-related factor 2 (NRF2), inhibits the expression of matrix metalloproteinases (MMPs) regulated by NF-kappaB, and decreases the expression of vascular endothelial growth factor (VEGF).	Rutin	39-44	vascular endothelial growth factor A	Rattus norvegicus	303-307
33164004-11	2020	We further confirmed that rutin and quercitrin could effectively inhibit the fibre formation of IAPP by fluorescence and TEM experiments.	Rutin	26-31	islet amyloid polypeptide	Homo sapiens	96-100
32830914-6	2020	Rutin suppressed the BisGMA-induced activation of caspase-3 and -9 rather than caspase-8.	Rutin	0-5	caspase 3	Homo sapiens	50-66
32950828-5	2020	Real time-PCR and western blot suggested that rutin, puerarin and 100 mg/(kg bw)/day silymarin could decrease the AlCl3-induced high expression of Bcl-2 associated X protein (Bax) mRNA and protein in hippocampus, but the expression of B cell lymphoma/leukemia-2 (Bcl-2) mRNA and protein was not significantly different among groups.	Rutin	46-51	BCL2 associated X, apoptosis regulator	Rattus norvegicus	147-173
32950828-5	2020	Real time-PCR and western blot suggested that rutin, puerarin and 100 mg/(kg bw)/day silymarin could decrease the AlCl3-induced high expression of Bcl-2 associated X protein (Bax) mRNA and protein in hippocampus, but the expression of B cell lymphoma/leukemia-2 (Bcl-2) mRNA and protein was not significantly different among groups.	Rutin	46-51	BCL2 associated X, apoptosis regulator	Rattus norvegicus	175-178
32950828-5	2020	Real time-PCR and western blot suggested that rutin, puerarin and 100 mg/(kg bw)/day silymarin could decrease the AlCl3-induced high expression of Bcl-2 associated X protein (Bax) mRNA and protein in hippocampus, but the expression of B cell lymphoma/leukemia-2 (Bcl-2) mRNA and protein was not significantly different among groups.	Rutin	46-51	BCL2, apoptosis regulator	Rattus norvegicus	235-261
32950828-5	2020	Real time-PCR and western blot suggested that rutin, puerarin and 100 mg/(kg bw)/day silymarin could decrease the AlCl3-induced high expression of Bcl-2 associated X protein (Bax) mRNA and protein in hippocampus, but the expression of B cell lymphoma/leukemia-2 (Bcl-2) mRNA and protein was not significantly different among groups.	Rutin	46-51	BCL2, apoptosis regulator	Rattus norvegicus	147-152
33050575-4	2020	Luteolin, apigenin, quercetin, myricetin, rutin, naringenin, epicatechin, and genistein activate the Nrf2/ARE pathway in both normal and cancer cells.	Rutin	42-47	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
32559694-7	2020	Rutin changed the positive rate of reactive oxygen species, the relative superoxide dismutase and catalase activities in the bacteria which exposed to OBS.	Rutin	0-5	catalase	Pseudomonas stutzeri	98-106
32529498-12	2020	Gene expression profiling of metabolic acidosis related genes (AQP2, AQP3 and V2R) and also histopathological results demonstrated the protective effect of rutin against diabetic ketoacidodis and fibrosis.	Rutin	156-161	aquaporin 2	Rattus norvegicus	63-67
32529498-12	2020	Gene expression profiling of metabolic acidosis related genes (AQP2, AQP3 and V2R) and also histopathological results demonstrated the protective effect of rutin against diabetic ketoacidodis and fibrosis.	Rutin	156-161	aquaporin 3 (Gill blood group)	Rattus norvegicus	69-73
32529498-12	2020	Gene expression profiling of metabolic acidosis related genes (AQP2, AQP3 and V2R) and also histopathological results demonstrated the protective effect of rutin against diabetic ketoacidodis and fibrosis.	Rutin	156-161	arginine vasopressin receptor 2	Rattus norvegicus	78-81
32233122-0	2020	Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF-beta1/alpha-SMA/Col I and III pathway.	Rutin	21-26	transforming growth factor beta 1	Homo sapiens	83-92
32233122-0	2020	Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF-beta1/alpha-SMA/Col I and III pathway.	Rutin	21-26	actin alpha 1, skeletal muscle	Homo sapiens	93-102
32744031-7	2020	RESULTS: Large, medium, and small doses of rutin were associated with significantly reduced FBS (P < 0.05), and increased levels of ISI, CAT, GSH-Px and SOD, as well as decreased MDA (P < 0.05).	Rutin	43-48	catalase	Rattus norvegicus	137-140
32744031-7	2020	RESULTS: Large, medium, and small doses of rutin were associated with significantly reduced FBS (P < 0.05), and increased levels of ISI, CAT, GSH-Px and SOD, as well as decreased MDA (P < 0.05).	Rutin	43-48	glutathione peroxidase 1	Rattus norvegicus	142-148
33612466-0	2020	Rutin coated gold nanoparticles prevent rhabdomyolysis-induced kidney injury via down-regulation of NF-kB, iNOS, IL-6 and up-regulation of HO-1 and Kim-1 genes in mice.	Rutin	0-5	nitric oxide synthase 2, inducible	Mus musculus	107-111
33612466-0	2020	Rutin coated gold nanoparticles prevent rhabdomyolysis-induced kidney injury via down-regulation of NF-kB, iNOS, IL-6 and up-regulation of HO-1 and Kim-1 genes in mice.	Rutin	0-5	interleukin 6	Mus musculus	113-117
33612466-0	2020	Rutin coated gold nanoparticles prevent rhabdomyolysis-induced kidney injury via down-regulation of NF-kB, iNOS, IL-6 and up-regulation of HO-1 and Kim-1 genes in mice.	Rutin	0-5	heme oxygenase 1	Mus musculus	139-143
33612466-0	2020	Rutin coated gold nanoparticles prevent rhabdomyolysis-induced kidney injury via down-regulation of NF-kB, iNOS, IL-6 and up-regulation of HO-1 and Kim-1 genes in mice.	Rutin	0-5	hepatitis A virus cellular receptor 1	Mus musculus	148-153
32587637-0	2020	Rutin via Increase in the CA3 Diameter of the Hippocampus Exerted Antidepressant-Like Effect in Mouse Model of Maternal Separation Stress: Possible Involvement of NMDA Receptors.	Rutin	0-5	carbonic anhydrase 3	Mus musculus	26-29
32676472-3	2020	We found that rutin suppresses LTA effects on the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, as well as the pro-inflammatory enzyme cyclooxygenase-2, preventing phosphorylation of the mitogen-activated protein kinases (MAPKs), p38, and c-Jun N-terminal kinase, and the increase of ROS production induced by LTA.	Rutin	14-19	catalase	Rattus norvegicus	92-100
32676472-3	2020	We found that rutin suppresses LTA effects on the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, as well as the pro-inflammatory enzyme cyclooxygenase-2, preventing phosphorylation of the mitogen-activated protein kinases (MAPKs), p38, and c-Jun N-terminal kinase, and the increase of ROS production induced by LTA.	Rutin	14-19	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	169-185
32676472-3	2020	We found that rutin suppresses LTA effects on the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, as well as the pro-inflammatory enzyme cyclooxygenase-2, preventing phosphorylation of the mitogen-activated protein kinases (MAPKs), p38, and c-Jun N-terminal kinase, and the increase of ROS production induced by LTA.	Rutin	14-19	mitogen activated protein kinase 14	Rattus norvegicus	264-267
32587637-8	2020	The CA3 diameter and percentage of dark neurons in the hippocampus of MS mice significantly decreased and increased, respectively, which partially reversed following rutin administration.	Rutin	166-171	carbonic anhydrase 3	Mus musculus	4-7
31954292-10	2020	While all the phytochemicals showed potential in inhibiting the enzymes, Rutin, Demethoxycurcumin and Acteoside were found to be most effective inhibitors of MAO-B, COMT and AChE respectively.	Rutin	73-78	monoamine oxidase B	Homo sapiens	158-163
32007794-12	2020	Rutin better prevented the decrease in the antioxidant defenses, increasing SOD by 34%, CAT by 246% and GST by 84% in the liver, as well as SOD by 119% and GST by 190% in the kidney.	Rutin	0-5	catalase	Rattus norvegicus	88-91
32222858-12	2020	In conclusion, rutin promoted the antioxidative stress ability, proliferation and osteogenic differentiation of PDLSCs through PI3K/AKT signaling pathway in LPS-induced inflammatory environment.	Rutin	15-20	AKT serine/threonine kinase 1	Homo sapiens	132-135
32466230-3	2020	Body weight gain considerably decreased, by approximately 33%, in the acid-treated rutin (AR) and quercetin (Q) groups compared to that in the HFD group.	Rutin	83-88	ferredoxin reductase	Mus musculus	90-92
32247814-3	2020	Mechanical activation was the most suitable method of rutin complex formation with (2-hydroxypropyl)-beta-cyclodextrin (HP-beta-CD), while the beta-cyclodextrin (beta-CD) complex successfully formed by kneading with an ethanol/water mixture.	Rutin	54-59	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	123-130
31954292-10	2020	While all the phytochemicals showed potential in inhibiting the enzymes, Rutin, Demethoxycurcumin and Acteoside were found to be most effective inhibitors of MAO-B, COMT and AChE respectively.	Rutin	73-78	catechol-O-methyltransferase	Homo sapiens	165-169
31954292-10	2020	While all the phytochemicals showed potential in inhibiting the enzymes, Rutin, Demethoxycurcumin and Acteoside were found to be most effective inhibitors of MAO-B, COMT and AChE respectively.	Rutin	73-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	174-178
31657862-0	2020	The effects of rutin and troxerutin on stabilizing SOD1 and inhibiting the protein aggregation.	Rutin	15-20	superoxide dismutase 1	Homo sapiens	51-55
31780308-1	2020	From UV-Vis spectrophotometric measurements the acidity constants of Rutin in aqueous media, at 25  C and 0.1 M ionic strength, were determined as: pK1 = 4.392 +- 0.167, pK2 = 7.130 +- 0.050, pK3 = 8.661 +- 0.042 and pK4 = 12.354 +- 0.020 and the molar absorptivity coefficients of all the Rutin pH-dependent species were reported as a function of wavelength.	Rutin	69-74	pyruvate kinase L/R	Homo sapiens	148-151
31780308-1	2020	From UV-Vis spectrophotometric measurements the acidity constants of Rutin in aqueous media, at 25  C and 0.1 M ionic strength, were determined as: pK1 = 4.392 +- 0.167, pK2 = 7.130 +- 0.050, pK3 = 8.661 +- 0.042 and pK4 = 12.354 +- 0.020 and the molar absorptivity coefficients of all the Rutin pH-dependent species were reported as a function of wavelength.	Rutin	69-74	prokineticin 2	Homo sapiens	170-173
31780308-1	2020	From UV-Vis spectrophotometric measurements the acidity constants of Rutin in aqueous media, at 25  C and 0.1 M ionic strength, were determined as: pK1 = 4.392 +- 0.167, pK2 = 7.130 +- 0.050, pK3 = 8.661 +- 0.042 and pK4 = 12.354 +- 0.020 and the molar absorptivity coefficients of all the Rutin pH-dependent species were reported as a function of wavelength.	Rutin	69-74	pyruvate kinase M1/2	Homo sapiens	192-195
31780308-2	2020	Furthermore, the electrochemical behavior of Rutin at neutral pH was investigated using a bare carbon paste electrode, CPE.	Rutin	45-50	carboxypeptidase E	Homo sapiens	119-122
31780308-4	2020	Moreover, the bare CPE was used for the electrochemical quantification of Rutin in neutral aqueous media, displaying the following features: (1.078 +- 0.440) muM, (3.594 +- 0.400) muM and (0.308 +- 0.014) muA muM-1 for the detection and quantification limits and sensitivity, respectively, within the 1-11 muM linear range.	Rutin	74-79	carboxypeptidase E	Homo sapiens	19-22
31780308-4	2020	Moreover, the bare CPE was used for the electrochemical quantification of Rutin in neutral aqueous media, displaying the following features: (1.078 +- 0.440) muM, (3.594 +- 0.400) muM and (0.308 +- 0.014) muA muM-1 for the detection and quantification limits and sensitivity, respectively, within the 1-11 muM linear range.	Rutin	74-79	PWWP domain containing 3A, DNA repair factor	Homo sapiens	209-214
31780308-6	2020	In like manner, the bare CPE is also shown as a robust electrochemical sensor that allows Rutin quantification even in the presence of ascorbic acid, commonly found in Rutin samples.	Rutin	90-95	carboxypeptidase E	Homo sapiens	25-28
31780308-6	2020	In like manner, the bare CPE is also shown as a robust electrochemical sensor that allows Rutin quantification even in the presence of ascorbic acid, commonly found in Rutin samples.	Rutin	168-173	carboxypeptidase E	Homo sapiens	25-28
31927393-0	2020	Formation of a bovine serum albumin diligand complex with rutin for the suppression of heme toxicity.	Rutin	58-63	albumin	Homo sapiens	28-35
31927393-4	2020	In this study, bindings of bovine serum albumin (BSA) to heme and/or rutin were investigated by experimental and molecular docking techniques.	Rutin	69-74	albumin	Homo sapiens	34-47
32036685-0	2020	Rutin promotes osteogenic differentiation of periodontal ligament stem cells through the GPR30-mediated PI3K/AKT/mTOR signaling pathway.	Rutin	0-5	G protein-coupled estrogen receptor 1	Homo sapiens	89-94
32036685-0	2020	Rutin promotes osteogenic differentiation of periodontal ligament stem cells through the GPR30-mediated PI3K/AKT/mTOR signaling pathway.	Rutin	0-5	AKT serine/threonine kinase 1	Homo sapiens	109-112
32036685-0	2020	Rutin promotes osteogenic differentiation of periodontal ligament stem cells through the GPR30-mediated PI3K/AKT/mTOR signaling pathway.	Rutin	0-5	mechanistic target of rapamycin kinase	Homo sapiens	113-117
32440327-7	2020	In addition, rutin decreased DNA damage and inhibited apoptotic cell death by decreasing the levels of proapoptotic proteins (Bax, caspase-3, caspase-9) and increasing the level of anti-apoptotic protein Bcl-2.	Rutin	13-18	BCL2 associated X, apoptosis regulator	Rattus norvegicus	126-129
32440327-7	2020	In addition, rutin decreased DNA damage and inhibited apoptotic cell death by decreasing the levels of proapoptotic proteins (Bax, caspase-3, caspase-9) and increasing the level of anti-apoptotic protein Bcl-2.	Rutin	13-18	caspase 3	Rattus norvegicus	131-140
31894470-0	2020	Revealing the Mechanism of EGCG, Genistein, Rutin, Quercetin, and Silibinin Against hIAPP Aggregation via Computational Simulations.	Rutin	44-49	islet amyloid polypeptide	Homo sapiens	84-89
31894470-5	2020	We show that these flavonoids can disaggregate Chain A and Chain B of hIAPP to reduce the extended conformation by binding with two regions of hIAPP, Leu12-Ala13-Asn14 and Asn31-Val32-Gly33-Ser34-Asn35, with the inhibitory ability of Genistein > Rutin > Quercetin > EGCG > Silibinin.	Rutin	246-251	islet amyloid polypeptide	Homo sapiens	70-75
32440327-7	2020	In addition, rutin decreased DNA damage and inhibited apoptotic cell death by decreasing the levels of proapoptotic proteins (Bax, caspase-3, caspase-9) and increasing the level of anti-apoptotic protein Bcl-2.	Rutin	13-18	caspase 9	Rattus norvegicus	142-151
32440327-7	2020	In addition, rutin decreased DNA damage and inhibited apoptotic cell death by decreasing the levels of proapoptotic proteins (Bax, caspase-3, caspase-9) and increasing the level of anti-apoptotic protein Bcl-2.	Rutin	13-18	BCL2, apoptosis regulator	Rattus norvegicus	204-209
31456155-9	2020	RESULTS: Rutin treatment significantly (p < 0.001) lowered retinal vascular endothelial growth factor, tumor necrosis factor-alpha, and aldose reductase.	Rutin	9-14	tumor necrosis factor	Rattus norvegicus	103-130
31785385-6	2020	Topical anti-inflammatory effect of CdE (0.001-1mg/ear) and rutin (0.003-0.03mg/ear) was evaluated by ear edema formation and inflammatory cells infiltration (MPO activity and histology) on a skin inflammation model induced by topical application of croton oil (1mg/ear).	Rutin	60-65	myeloperoxidase	Mus musculus	159-162
31785385-12	2020	Treatments reduced the MPO activity (42 +- 4% to CdE; 1mg/ear and 30 +- 8% to rutin; 0.03 mg/ear).	Rutin	78-83	myeloperoxidase	Mus musculus	23-26
32016695-0	2020	Rutin protects against pirarubicin-induced cardiotoxicity by adjusting microRNA-125b-1-3p-mediated JunD signaling pathway.	Rutin	0-5	jun D proto-oncogene	Mus musculus	99-103
32016695-9	2020	Our data also indicated that RUT activated JunD signaling pathways, thereby affecting the expression levels of some apoptotic proteins by decreasing miR-125b-1-3p expression level.	Rutin	29-32	jun D proto-oncogene	Mus musculus	43-47
32016695-12	2020	Therefore, we inferred that the protective effect of RUT on THP cardiotoxicity was achieved through regulation of the JunD gene by miR-125b-1-3p.	Rutin	53-56	jun D proto-oncogene	Mus musculus	118-122
32016695-12	2020	Therefore, we inferred that the protective effect of RUT on THP cardiotoxicity was achieved through regulation of the JunD gene by miR-125b-1-3p.	Rutin	53-56	microRNA 125b-1	Mus musculus	131-141
32030599-0	2020	Neuroprotective effect of rutin against colistin-induced oxidative stress, inflammation and apoptosis in rat brain associated with the CREB/BDNF expressions.	Rutin	26-31	cAMP responsive element binding protein 1	Rattus norvegicus	135-139
32030599-0	2020	Neuroprotective effect of rutin against colistin-induced oxidative stress, inflammation and apoptosis in rat brain associated with the CREB/BDNF expressions.	Rutin	26-31	brain-derived neurotrophic factor	Rattus norvegicus	140-144
31836556-13	2020	However, treatment with rutin decreased cholinesterase activities and the level of oxidative stress markers in cadmium-exposed rats.	Rutin	24-29	butyrylcholinesterase	Rattus norvegicus	40-54
32276903-8	2020	Furthermore, the expression of COL-I and TGF-beta1 in kidney tissues increased significantly in the diabetic mice, which were antagonized by the rutin treatment.	Rutin	145-150	transforming growth factor, beta 1	Mus musculus	41-50
31767147-9	2020	AM + rutin (100 mg/kg body weight) significantly decreased bax, p53, CCR and increased bcl-2 expression.	Rutin	5-10	B cell leukemia/lymphoma 2	Mus musculus	87-92
32024167-0	2020	Structural Changes of Sarco/Endoplasmic Reticulum Ca2+-ATPase Induced by Rutin Arachidonate: A Molecular Dynamics Study.	Rutin	73-91	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	22-61
31630006-0	2020	Rutin protects human periodontal ligament stem cells from TNF-alpha induced damage to osteogenic differentiation through suppressing mTOR signaling pathway in inflammatory environment.	Rutin	0-5	tumor necrosis factor	Homo sapiens	58-67
31630006-0	2020	Rutin protects human periodontal ligament stem cells from TNF-alpha induced damage to osteogenic differentiation through suppressing mTOR signaling pathway in inflammatory environment.	Rutin	0-5	mechanistic target of rapamycin kinase	Homo sapiens	133-137
31630006-1	2020	OBJECTIVES: To investigate whether rutin could protect human periodontal ligament stem cells (hPDLSCs) from TNF-alpha induced damage to osteogenic differentiation in inflammatory environment and detect the underlying mechanism.	Rutin	35-40	tumor necrosis factor	Homo sapiens	108-117
31630006-10	2020	Moreover, rutin could affect TNF-alpha (20 ng/mL) induced damage to osteogenic differentiation of hPDLSCs in a dose-dependent manner, 10 mumol/L rutin could significantly reverse the damage caused by TNF-alpha.	Rutin	10-15	tumor necrosis factor	Homo sapiens	29-38
31630006-10	2020	Moreover, rutin could affect TNF-alpha (20 ng/mL) induced damage to osteogenic differentiation of hPDLSCs in a dose-dependent manner, 10 mumol/L rutin could significantly reverse the damage caused by TNF-alpha.	Rutin	10-15	tumor necrosis factor	Homo sapiens	200-209
31630006-10	2020	Moreover, rutin could affect TNF-alpha (20 ng/mL) induced damage to osteogenic differentiation of hPDLSCs in a dose-dependent manner, 10 mumol/L rutin could significantly reverse the damage caused by TNF-alpha.	Rutin	145-150	tumor necrosis factor	Homo sapiens	29-38
31630006-10	2020	Moreover, rutin could affect TNF-alpha (20 ng/mL) induced damage to osteogenic differentiation of hPDLSCs in a dose-dependent manner, 10 mumol/L rutin could significantly reverse the damage caused by TNF-alpha.	Rutin	145-150	tumor necrosis factor	Homo sapiens	200-209
31630006-11	2020	In addition, rutin inhibited TNF-alpha-activated mTOR signal transduction by inhibiting the phosphorylation of mTOR, similar to the effects of rapamycin(a specific mTOR inhibitor).	Rutin	13-18	tumor necrosis factor	Homo sapiens	29-38
31630006-11	2020	In addition, rutin inhibited TNF-alpha-activated mTOR signal transduction by inhibiting the phosphorylation of mTOR, similar to the effects of rapamycin(a specific mTOR inhibitor).	Rutin	13-18	mechanistic target of rapamycin kinase	Homo sapiens	49-53
31630006-11	2020	In addition, rutin inhibited TNF-alpha-activated mTOR signal transduction by inhibiting the phosphorylation of mTOR, similar to the effects of rapamycin(a specific mTOR inhibitor).	Rutin	13-18	mechanistic target of rapamycin kinase	Homo sapiens	111-115
31630006-11	2020	In addition, rutin inhibited TNF-alpha-activated mTOR signal transduction by inhibiting the phosphorylation of mTOR, similar to the effects of rapamycin(a specific mTOR inhibitor).	Rutin	13-18	mechanistic target of rapamycin kinase	Homo sapiens	111-115
31630006-12	2020	CONCLUSIONS: Rutin could protect hPDLSCs from TNF-alpha induced damage to osteogenic differentiation in inflammatory environment, and rutin is expected to become a new candidate drug for the treatment of bone defect of periodontitis.	Rutin	13-18	tumor necrosis factor	Homo sapiens	46-55
31707064-0	2020	Formation of a bovine serum albumin diligand complex with rutin and single-walled carbon nanotubes for the reduction of cytotoxicity.	Rutin	58-63	albumin	Homo sapiens	22-35
31707064-4	2020	In this study, bindings of bovine serum albumin (BSA) to single-walled CNTs and/or rutin were investigated by fluorescence and molecular docking techniques.	Rutin	83-88	albumin	Homo sapiens	34-47
31767147-8	2020	AM and DP significantly increased caspases 3 and 9 activities, enhanced mATPase activity but co-treatment with rutin (100 mg/kg) decreased these effects significantly.	Rutin	111-116	caspase 3	Mus musculus	34-50
31767147-9	2020	AM + rutin (100 mg/kg body weight) significantly decreased bax, p53, CCR and increased bcl-2 expression.	Rutin	5-10	BCL2-associated X protein	Mus musculus	59-62
31767147-9	2020	AM + rutin (100 mg/kg body weight) significantly decreased bax, p53, CCR and increased bcl-2 expression.	Rutin	5-10	transformation related protein 53, pseudogene	Mus musculus	64-67
31747631-0	2020	Effect of rutin on anxiety-like behavior and activity of acetylcholinesterase isoforms in specific brain regions of pentylenetetrazol-treated mice.	Rutin	10-15	acetylcholinesterase	Mus musculus	57-77
31747631-1	2020	The aim of the present study was to investigate the effect of rutin administration (100 mg/kg/day) to pentylenetetrazol (PTZ)-treated Balb-c mice (60 mg/kg/day), with respect to anxiety-like behavior using both open-field and elevated plus-maze (EPM) tests, and acetylcholinesterase (AChE) activity in salt-soluble (SS) fraction and detergent-soluble (DS) fraction of the cerebral cortex, hippocampus, striatum, midbrain, and diencephalon.	Rutin	62-67	acetylcholinesterase	Mus musculus	262-282
31747631-1	2020	The aim of the present study was to investigate the effect of rutin administration (100 mg/kg/day) to pentylenetetrazol (PTZ)-treated Balb-c mice (60 mg/kg/day), with respect to anxiety-like behavior using both open-field and elevated plus-maze (EPM) tests, and acetylcholinesterase (AChE) activity in salt-soluble (SS) fraction and detergent-soluble (DS) fraction of the cerebral cortex, hippocampus, striatum, midbrain, and diencephalon.	Rutin	62-67	acetylcholinesterase	Mus musculus	284-288
31747631-3	2020	Rutin administration to normal mice did not affect their behavior, while it induced a brain region-specific reduction in SS-AChE and a significant decrease in DS-AChE in all brain regions.	Rutin	0-5	acetylcholinesterase	Mus musculus	124-128
31747631-3	2020	Rutin administration to normal mice did not affect their behavior, while it induced a brain region-specific reduction in SS-AChE and a significant decrease in DS-AChE in all brain regions.	Rutin	0-5	acetylcholinesterase	Mus musculus	162-166
31747631-4	2020	We demonstrated for the first time that pretreatment of PTZ-mice with rutin (PTZ + Rutin group) prevented the manifestation of anxiety and induced interestingly a further significant reduction on the SS- and DS-AChE activities only in the cerebral cortex and striatum, in comparison with PTZ group.	Rutin	70-75	acetylcholinesterase	Mus musculus	211-215
31747631-4	2020	We demonstrated for the first time that pretreatment of PTZ-mice with rutin (PTZ + Rutin group) prevented the manifestation of anxiety and induced interestingly a further significant reduction on the SS- and DS-AChE activities only in the cerebral cortex and striatum, in comparison with PTZ group.	Rutin	83-88	acetylcholinesterase	Mus musculus	211-215
31456155-9	2020	RESULTS: Rutin treatment significantly (p < 0.001) lowered retinal vascular endothelial growth factor, tumor necrosis factor-alpha, and aldose reductase.	Rutin	9-14	aldo-keto reductase family 1 member B1	Rattus norvegicus	136-152
31646664-4	2020	The dose-dependent protective effects against H2 O2 -induced oxidative stress of the rutin-Lys MRPs may involve the inhibition of reactive oxygen species generation, enhancement of the superoxide dismutase and catalase activities, along with the activation of the Nrf2-dependent pathway and upregulation of phase II antioxidant genes (including NQO1, HO-1, GCLG, and GCLM).	Rutin	85-90	NFE2 like bZIP transcription factor 2	Homo sapiens	264-268
31646664-4	2020	The dose-dependent protective effects against H2 O2 -induced oxidative stress of the rutin-Lys MRPs may involve the inhibition of reactive oxygen species generation, enhancement of the superoxide dismutase and catalase activities, along with the activation of the Nrf2-dependent pathway and upregulation of phase II antioxidant genes (including NQO1, HO-1, GCLG, and GCLM).	Rutin	85-90	NAD(P)H quinone dehydrogenase 1	Homo sapiens	345-349
31646664-7	2020	This study shows that a 30-min thermal treatment at 120 C generates antioxidative MRPs in the rutin-Lys, rutin-His, rutin-Ile and rutin-Glu model systems, which can directly inhibit reactive oxygen species generation and enhance SOD and CAT activities while activating the Nrf2-dependent pathway and upregulating the expression of phase II detoxifying antioxidant genes.	Rutin	94-99	NFE2 like bZIP transcription factor 2	Homo sapiens	273-277
31646664-7	2020	This study shows that a 30-min thermal treatment at 120 C generates antioxidative MRPs in the rutin-Lys, rutin-His, rutin-Ile and rutin-Glu model systems, which can directly inhibit reactive oxygen species generation and enhance SOD and CAT activities while activating the Nrf2-dependent pathway and upregulating the expression of phase II detoxifying antioxidant genes.	Rutin	116-125	NFE2 like bZIP transcription factor 2	Homo sapiens	273-277
31646664-4	2020	The dose-dependent protective effects against H2 O2 -induced oxidative stress of the rutin-Lys MRPs may involve the inhibition of reactive oxygen species generation, enhancement of the superoxide dismutase and catalase activities, along with the activation of the Nrf2-dependent pathway and upregulation of phase II antioxidant genes (including NQO1, HO-1, GCLG, and GCLM).	Rutin	85-90	heme oxygenase 1	Homo sapiens	351-355
31646664-4	2020	The dose-dependent protective effects against H2 O2 -induced oxidative stress of the rutin-Lys MRPs may involve the inhibition of reactive oxygen species generation, enhancement of the superoxide dismutase and catalase activities, along with the activation of the Nrf2-dependent pathway and upregulation of phase II antioxidant genes (including NQO1, HO-1, GCLG, and GCLM).	Rutin	85-90	glutamate-cysteine ligase modifier subunit	Homo sapiens	367-371
31781632-0	2019	P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin.	Rutin	123-128	mitogen-activated protein kinase 14	Homo sapiens	0-3
31882676-12	2019	According to the CYP2C19 polymorphisms, 79.5% of the RUT-positive patients were extensive metabolizers.	Rutin	53-56	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	17-24
30945072-3	2019	The effect of rutin and its mechanisms of action were evaluated in a model of hyperalgesia induced by G-CSF in mice.	Rutin	14-19	colony stimulating factor 3 (granulocyte)	Mus musculus	102-107
30945072-4	2019	The mechanical hyperalgesia induced by G-CSF was reduced by treatment with rutin in a dose-dependent manner.	Rutin	75-80	colony stimulating factor 3 (granulocyte)	Mus musculus	39-44
30945072-5	2019	Treatment with both rutin + morphine or rutin + indomethacin, at doses that are ineffectual per se, significantly reduced the pain caused by G-CSF.	Rutin	20-25	colony stimulating factor 3 (granulocyte)	Mus musculus	141-146
30945072-5	2019	Treatment with both rutin + morphine or rutin + indomethacin, at doses that are ineffectual per se, significantly reduced the pain caused by G-CSF.	Rutin	40-45	colony stimulating factor 3 (granulocyte)	Mus musculus	141-146
30945072-7	2019	Rutin also reduced the pro-hyperalgesic and increased anti-hyperalgesic cytokine production induced by G-CSF.	Rutin	0-5	colony stimulating factor 3 (granulocyte)	Mus musculus	103-108
30945072-8	2019	Furthermore, rutin inhibited the activation of the nuclear factor kappa-light-chain enhancer of activated B cells (NFkappaB), which might explain the inhibition of the cytokine production.	Rutin	13-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-123
30945072-9	2019	Treatment with rutin upregulated the decreased mRNA expression of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) combined with enhancement of the mRNA expression of the Nrf2 downstream target heme oxygenase (HO-1).	Rutin	15-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	70-113
30945072-9	2019	Treatment with rutin upregulated the decreased mRNA expression of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) combined with enhancement of the mRNA expression of the Nrf2 downstream target heme oxygenase (HO-1).	Rutin	15-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119
30945072-9	2019	Treatment with rutin upregulated the decreased mRNA expression of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) combined with enhancement of the mRNA expression of the Nrf2 downstream target heme oxygenase (HO-1).	Rutin	15-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	177-181
30945072-9	2019	Treatment with rutin upregulated the decreased mRNA expression of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) combined with enhancement of the mRNA expression of the Nrf2 downstream target heme oxygenase (HO-1).	Rutin	15-20	heme oxygenase 1	Mus musculus	216-220
30945072-13	2019	The present study demonstrates rutin as a promising pharmacological approach to treat the pain induced by G-CSF without impairing its primary therapeutic benefit of mobilizing hematopoietic progenitor cells into the blood.	Rutin	31-36	colony stimulating factor 3 (granulocyte)	Mus musculus	106-111
31385777-9	2020	Moreover, Rutin provoked apoptosis by inducing decrease in MMP and activation of caspase-3.	Rutin	10-15	caspase 3	Homo sapiens	81-90
31442956-5	2019	The histological alterations and epidermal growth factor receptor (EGFR) expression in the HgCl2-induced liver tissues were decreased by administration of rutin.	Rutin	155-160	epidermal growth factor receptor	Rattus norvegicus	33-65
31442956-5	2019	The histological alterations and epidermal growth factor receptor (EGFR) expression in the HgCl2-induced liver tissues were decreased by administration of rutin.	Rutin	155-160	epidermal growth factor receptor	Rattus norvegicus	67-71
31781632-8	2019	The mechanism of RT-induced apoptosis may be associated with the activation of the p38/Caspase signal pathway.	Rutin	17-19	mitogen-activated protein kinase 14	Homo sapiens	83-86
31382673-0	2019	Quercetin-3-Rutinoside Blocks the Disassembly of Cholera Toxin by Protein Disulfide Isomerase.	Rutin	0-22	prolyl 4-hydroxylase subunit beta	Homo sapiens	66-93
31377139-9	2019	In human neuroblastoma cell line SH-SY5Y, rutin-liposomes (lipid 25 muM + rutin 16.7 muM) attenuated glutamate-induced cytotoxicity, in part by reducing the formation of intracellular reactive species, pointing to their potential application as new functional neuroprotective agents.	Rutin	42-47	latexin	Homo sapiens	68-71
31377139-9	2019	In human neuroblastoma cell line SH-SY5Y, rutin-liposomes (lipid 25 muM + rutin 16.7 muM) attenuated glutamate-induced cytotoxicity, in part by reducing the formation of intracellular reactive species, pointing to their potential application as new functional neuroprotective agents.	Rutin	42-47	latexin	Homo sapiens	85-88
31929945-5	2019	The linear range for rutin was 0.05-50 muM with a detection limit of 0.005 muM (S/N = 3).	Rutin	21-26	latexin	Homo sapiens	39-42
31929945-5	2019	The linear range for rutin was 0.05-50 muM with a detection limit of 0.005 muM (S/N = 3).	Rutin	21-26	latexin	Homo sapiens	75-78
31437127-7	2019	In addition, EMPs obtained from the four groups were pretreated with the PDI inhibitor rutin; then, their effects on the platelets of normal C57 mice were characterized.	Rutin	87-92	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	73-76
31055769-5	2019	This is demonstrated by a significant reduction in the expression levels of BiP, significantly reduced basal respiration, maximal respiration, and spare respiratory capacity as well as a significant increase in the expression levels of CHOP; however, these effects were significantly attenuated following pretreatment with rutin.	Rutin	323-328	heat shock protein family A (Hsp70) member 5	Homo sapiens	76-79
31055769-5	2019	This is demonstrated by a significant reduction in the expression levels of BiP, significantly reduced basal respiration, maximal respiration, and spare respiratory capacity as well as a significant increase in the expression levels of CHOP; however, these effects were significantly attenuated following pretreatment with rutin.	Rutin	323-328	DNA damage inducible transcript 3	Homo sapiens	236-240
31737218-0	2019	Rutin suppresses FNDC1 expression in bone marrow mesenchymal stem cells to inhibit postmenopausal osteoporosis.	Rutin	0-5	fibronectin type III domain containing 1	Rattus norvegicus	17-22
31737218-3	2019	Further study using whole gene expression profiling revealed that FNDC1, a fibronectin type III domain-containing protein, may be a novel bone metabolism-related factor that is decreased in rutin-treated rats.	Rutin	190-195	fibronectin type III domain containing 1	Rattus norvegicus	66-71
31737218-5	2019	Micro-CT, western blotting, quantitative PCR, transmission electron microscopy, and Alizarin Red mineralization staining assays were performed to evaluate bone density, FNDC1 expression and autophagy to determine whether FNDC1 might play a significant role in rutin-inhibited trabecular bone loss in rats.	Rutin	260-265	fibronectin type III domain containing 1	Rattus norvegicus	221-226
31737218-6	2019	FNDC1 expression was high in the osteoporosis group, whereas rutin treatment facilitated FNDC1 downregulation.	Rutin	61-66	fibronectin type III domain containing 1	Rattus norvegicus	89-94
31737218-7	2019	In addition, rutin promoted bone marrow mesenchymal stem cell autophagy by inhibiting phosphorylated Akt in osteoporosis.	Rutin	13-18	AKT serine/threonine kinase 1	Rattus norvegicus	101-104
31737218-8	2019	In summary, our study shows that rutin could regulate FNCD1 level and autophagy through the Akt/mTOR signaling pathway to provide a novel therapeutic strategy for osteoporosis.	Rutin	33-38	AKT serine/threonine kinase 1	Rattus norvegicus	92-95
31737218-8	2019	In summary, our study shows that rutin could regulate FNCD1 level and autophagy through the Akt/mTOR signaling pathway to provide a novel therapeutic strategy for osteoporosis.	Rutin	33-38	mechanistic target of rapamycin kinase	Rattus norvegicus	96-100
31382673-2	2019	Quercetin-3-rutinoside (Q3R) blocks this activity, but its inhibitory mechanism against PDI is not fully understood.	Rutin	0-22	prolyl 4-hydroxylase subunit beta	Homo sapiens	88-91
30600471-18	2019	The levels of caspase-3 enzyme significantly increased (p &lt; 0.001) in the CFZ group and were reduced toward the normal values by olmesartan and rutin administration.	Rutin	147-152	caspase 3	Rattus norvegicus	14-23
31592435-0	2019	Synergetic Impact of Combined 5-Fluorouracil and Rutin on Apoptosis in PC3 Cancer Cells through the Modulation of P53 Gene Expression.	Rutin	49-54	tumor protein p53	Homo sapiens	114-117
31592435-3	2019	Combined effects of rutin with the widely used anti-cancer drug, 5-fluorouracil (5-FU), on prostate cancer cell line (PC3) was investigated herein.	Rutin	20-25	chromobox 8	Homo sapiens	118-121
31592435-4	2019	Methods: Different concentrations of combined 5-FU and rutin were applied to PC3 cells compared to separate treatment for 48 hours.	Rutin	55-60	chromobox 8	Homo sapiens	77-80
31592435-9	2019	Combination of 5-FU/rutin enhanced apoptosis and p53 gene expression in PC3 cells.	Rutin	20-25	tumor protein p53	Homo sapiens	49-52
31592435-9	2019	Combination of 5-FU/rutin enhanced apoptosis and p53 gene expression in PC3 cells.	Rutin	20-25	chromobox 8	Homo sapiens	72-75
31592435-10	2019	PC3 cell colony counts and Bcl-2 signaling protein were decreased by 5-FU/rutin combination.	Rutin	74-79	chromobox 8	Homo sapiens	0-3
31592435-10	2019	PC3 cell colony counts and Bcl-2 signaling protein were decreased by 5-FU/rutin combination.	Rutin	74-79	BCL2 apoptosis regulator	Homo sapiens	27-32
31592435-11	2019	Conclusion: Synergistic effects of 5-FU/rutin combination on PC3 cells line enhanced apoptosis, p53 gene expression, and down-regulation of Bcl-2 protein, compared to control separate application.	Rutin	40-45	chromobox 8	Homo sapiens	61-64
31592435-11	2019	Conclusion: Synergistic effects of 5-FU/rutin combination on PC3 cells line enhanced apoptosis, p53 gene expression, and down-regulation of Bcl-2 protein, compared to control separate application.	Rutin	40-45	tumor protein p53	Homo sapiens	96-99
31592435-11	2019	Conclusion: Synergistic effects of 5-FU/rutin combination on PC3 cells line enhanced apoptosis, p53 gene expression, and down-regulation of Bcl-2 protein, compared to control separate application.	Rutin	40-45	BCL2 apoptosis regulator	Homo sapiens	140-145
30600471-19	2019	Furthermore, the results of NOS-2, NF-kappaB, IkBa, and IL-17 protein estimation and the histopathological evaluation strengthened our findings that rutin exhibits a protective effect against CFZ-induced nephrotoxicity.	Rutin	149-154	nitric oxide synthase 2	Rattus norvegicus	28-33
30600471-19	2019	Furthermore, the results of NOS-2, NF-kappaB, IkBa, and IL-17 protein estimation and the histopathological evaluation strengthened our findings that rutin exhibits a protective effect against CFZ-induced nephrotoxicity.	Rutin	149-154	interleukin 17A	Rattus norvegicus	56-61
30972687-0	2019	Rutin alleviates cadmium-induced neurotoxicity in Wistar rats: involvement of modulation of nucleotide-degrading enzymes and monoamine oxidase.	Rutin	0-5	monoamine oxidase A	Rattus norvegicus	125-142
30972687-8	2019	However, treatment with rutin decreased ectonucleotidase, ADA and MAO activities in cadmium-induced rats.	Rutin	24-29	monoamine oxidase A	Rattus norvegicus	66-69
30939819-5	2019	In addition, 10 phenolic compounds in the common bean extracts were detected and quantified by high performance liquid chromatography (HPLC), including protocatechuic acid, catechin, chlorogenic acid, epicatechin, ferulic acid, coumarin, rutin, myricetin, cinnamic acid, and genistein.	Rutin	238-243	brain expressed associated with NEDD4 1	Homo sapiens	49-53
31792473-9	2019	RESULTS: The results of CCK-8 and ALP activity analysis showed that rutin at 10 mumol/L could significantly promote the proliferation and differentiation of periodontal stem cells under inflammatory state.	Rutin	68-73	alkaline phosphatase, placental	Homo sapiens	34-37
31792473-10	2019	ALP staining and alizarin red staining proved that (10 mumol/L) rutin could improve osteogenic differentiation of periodontal ligament stem cells under inflammatory microenvironment.	Rutin	64-69	alkaline phosphatase, placental	Homo sapiens	0-3
31792473-11	2019	RT-PCR and Western blot results showed that rutin could enhance the expression of osteogenic genes and proteins such as COL1, ALP, and RUNX2 under inflammatory state.	Rutin	44-49	alkaline phosphatase, placental	Homo sapiens	126-129
31792473-11	2019	RT-PCR and Western blot results showed that rutin could enhance the expression of osteogenic genes and proteins such as COL1, ALP, and RUNX2 under inflammatory state.	Rutin	44-49	RUNX family transcription factor 2	Homo sapiens	135-140
30753670-12	2019	Moreover, LPS induced reactive oxygen species (ROS) production, and NF-kappaB activation was significantly blocked by 100 muM of rutin.	Rutin	129-134	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	68-77
31134235-4	2019	This study showed for the first time that rutin (IC50 = 10.4 +- 0.8 muM), and human metabolite quercetin-3-O-glucuronide (IC50 = 8.2 +- 0.4 muM), target L. amazonensis arginase.	Rutin	42-47	latexin	Homo sapiens	68-71
31134235-4	2019	This study showed for the first time that rutin (IC50 = 10.4 +- 0.8 muM), and human metabolite quercetin-3-O-glucuronide (IC50 = 8.2 +- 0.4 muM), target L. amazonensis arginase.	Rutin	42-47	latexin	Homo sapiens	140-143
31134397-6	2019	Under optimal conditions, the sensor has a linear response in the 1-10 muM rutin concentration range, and a 0.01 muM lower detection limit (at an S/N ratio of 3).	Rutin	75-80	latexin	Homo sapiens	71-74
31065489-7	2019	However, treatment with 50 mg/kg quercetin glycosides significantly reduced the mRNA expression of TNF-alpha, IL-6, and iNOS by more than 40%.	Rutin	33-53	tumor necrosis factor	Rattus norvegicus	99-108
31065489-7	2019	However, treatment with 50 mg/kg quercetin glycosides significantly reduced the mRNA expression of TNF-alpha, IL-6, and iNOS by more than 40%.	Rutin	33-53	interleukin 6	Rattus norvegicus	110-114
31065489-7	2019	However, treatment with 50 mg/kg quercetin glycosides significantly reduced the mRNA expression of TNF-alpha, IL-6, and iNOS by more than 40%.	Rutin	33-53	nitric oxide synthase 2	Rattus norvegicus	120-124
31350736-7	2019	HPLC-UV analyses for P-gp inhibitors in these extracts revealed several phenolic compounds such as rutin, gallic acid, and ellagic acid reported to decrease P-gp expression and/or directly modify its function.	Rutin	99-104	ATP binding cassette subfamily B member 1	Homo sapiens	21-25
31350736-7	2019	HPLC-UV analyses for P-gp inhibitors in these extracts revealed several phenolic compounds such as rutin, gallic acid, and ellagic acid reported to decrease P-gp expression and/or directly modify its function.	Rutin	99-104	ATP binding cassette subfamily B member 1	Homo sapiens	157-161
31366075-1	2019	The aim of this study was to estimate the mode of thyroid peroxidase (TPO) inhibition by polyphenols: Chlorogenic acid, rosmarinic acid, quercetin, and rutin.	Rutin	152-157	thyroid peroxidase	Homo sapiens	70-73
31366075-2	2019	All the tested polyphenols inhibited TPO; the IC50 values ranged from 0.004 mM to 1.44 mM (for rosmarinic acid and rutin, respectively).	Rutin	115-120	thyroid peroxidase	Homo sapiens	37-40
31366075-4	2019	Rutin and rosmarinic acid showed competitive, quercetin-uncompetitive and chlorogenic acid-noncompetitive inhibition effect on TPO.	Rutin	0-5	thyroid peroxidase	Homo sapiens	127-130
31138757-0	2019	Low concentration of rutin treatment might alleviate the cardiotoxicity effect of pirarubicin on cardiomyocytes via activation of PI3K/AKT/mTOR signaling pathway.	Rutin	21-26	AKT serine/threonine kinase 1	Homo sapiens	135-138
31138757-0	2019	Low concentration of rutin treatment might alleviate the cardiotoxicity effect of pirarubicin on cardiomyocytes via activation of PI3K/AKT/mTOR signaling pathway.	Rutin	21-26	mechanistic target of rapamycin kinase	Homo sapiens	139-143
31138757-4	2019	Phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is critical for cellular survival, proliferation and metabolism, and thus we speculated rutin might perform a protective role in cardiomyocytes via PI3K/AKT/mTOR signaling pathway.	Rutin	211-216	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-37
31138757-4	2019	Phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is critical for cellular survival, proliferation and metabolism, and thus we speculated rutin might perform a protective role in cardiomyocytes via PI3K/AKT/mTOR signaling pathway.	Rutin	211-216	AKT serine/threonine kinase 1	Homo sapiens	63-66
31138757-4	2019	Phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is critical for cellular survival, proliferation and metabolism, and thus we speculated rutin might perform a protective role in cardiomyocytes via PI3K/AKT/mTOR signaling pathway.	Rutin	211-216	mechanistic target of rapamycin kinase	Homo sapiens	68-97
31138757-4	2019	Phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is critical for cellular survival, proliferation and metabolism, and thus we speculated rutin might perform a protective role in cardiomyocytes via PI3K/AKT/mTOR signaling pathway.	Rutin	211-216	mechanistic target of rapamycin kinase	Homo sapiens	99-103
31138757-4	2019	Phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is critical for cellular survival, proliferation and metabolism, and thus we speculated rutin might perform a protective role in cardiomyocytes via PI3K/AKT/mTOR signaling pathway.	Rutin	211-216	AKT serine/threonine kinase 1	Homo sapiens	276-279
31138757-4	2019	Phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is critical for cellular survival, proliferation and metabolism, and thus we speculated rutin might perform a protective role in cardiomyocytes via PI3K/AKT/mTOR signaling pathway.	Rutin	211-216	mechanistic target of rapamycin kinase	Homo sapiens	280-284
31138757-8	2019	Thus, we speculated that rutin could increase the activation of PI3K/AKT/mTOR signaling pathway, further decrease the oxidative stress level via increasing the expression of antioxidative stress enzymes with the increasing concentration of angiogenesis promoting factors, resulting in the protective role in cardiomyocytes and cardiac function.	Rutin	25-30	AKT serine/threonine kinase 1	Homo sapiens	69-72
31138757-8	2019	Thus, we speculated that rutin could increase the activation of PI3K/AKT/mTOR signaling pathway, further decrease the oxidative stress level via increasing the expression of antioxidative stress enzymes with the increasing concentration of angiogenesis promoting factors, resulting in the protective role in cardiomyocytes and cardiac function.	Rutin	25-30	mechanistic target of rapamycin kinase	Homo sapiens	73-77
31179192-0	2019	Rutin ameliorates carbon tetrachloride (CCl4)-induced hepatorenal toxicity and hypogonadism in male rats.	Rutin	0-5	C-C motif chemokine ligand 4	Rattus norvegicus	40-44
31179192-2	2019	This study aims to explore the ameliorative effects of rutin against carbon tetrachloride (CCl4) toxicity in male rats.	Rutin	55-60	C-C motif chemokine ligand 4	Rattus norvegicus	91-95
31179192-6	2019	In addition, CCl4 induced profound elevation of free radical generation and oxidative stress, as evidenced by increasing lipid peroxidation and reducing catalase, superoxide dismutase and glutathione peroxidase activities in liver, kidney and testicular tissues; these effects were suppressed by coexposure with rutin.	Rutin	312-317	C-C motif chemokine ligand 4	Rattus norvegicus	13-17
31179192-7	2019	Moreover, the increase in the levels of serum triglycerides, cholesterol, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol induced by CCl4 was effectively counteracted by rutin.	Rutin	204-209	C-C motif chemokine ligand 4	Rattus norvegicus	167-171
31179192-8	2019	The decrease in the level of high-density lipoprotein cholesterol in the CCl4 group was also counteracted by rutin treatment.	Rutin	109-114	C-C motif chemokine ligand 4	Rattus norvegicus	73-77
30679022-0	2019	Rutin and curcumin reduce inflammation, triglyceride levels and ADA activity in serum and immune cells in a model of hyperlipidemia.	Rutin	0-5	adenosine deaminase	Rattus norvegicus	64-67
30898639-2	2019	In order to increase the lipophilicity of the flavonoid and to dissolve it in SEDDS, enzymatic acylation of rutin with lauric acid was catalyzed by lipase from Candida antarctica in acetone.	Rutin	108-113	PAN0_003d1715	Moesziomyces antarcticus	148-154
30725351-0	2019	Combination treatment of podophyllotoxin and rutin promotes mouse Lgr5+ ve intestinal stem cells survival against lethal radiation injury through Wnt signaling.	Rutin	45-50	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	66-70
30783768-7	2019	The ascorbic acid and rutin combination also showed increased antioxidant enzyme activity (catalase, superoxide dismutase, thioredoxin reductase), which was impaired following UV irradiation.	Rutin	22-27	peroxiredoxin 5	Homo sapiens	123-144
30458280-18	2019	Furthermore, molecular docking reveals that rutin and chlorogenic acid effectively act as FXR agonists.	Rutin	44-49	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	90-93
30668448-15	2019	The qPCR analyses revealed that t-BHP potently up-regulates the iNOS and down regulate the Nrf2 expression which was ameliorated with rutin treatment in a dose-dependent manner like silymarin.	Rutin	134-139	nitric oxide synthase 2, inducible	Mus musculus	64-68
30668448-15	2019	The qPCR analyses revealed that t-BHP potently up-regulates the iNOS and down regulate the Nrf2 expression which was ameliorated with rutin treatment in a dose-dependent manner like silymarin.	Rutin	134-139	nuclear factor, erythroid derived 2, like 2	Mus musculus	91-95
30668448-16	2019	CONCLUSION: Our findings demonstrate that rutin potentiates its beneficial aspect by displaying a profound role in iNOS-Nrf2 signaling pathway.	Rutin	42-47	nitric oxide synthase 2, inducible	Mus musculus	115-119
30668448-16	2019	CONCLUSION: Our findings demonstrate that rutin potentiates its beneficial aspect by displaying a profound role in iNOS-Nrf2 signaling pathway.	Rutin	42-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	120-124
30365940-8	2019	Rutin attenuated H/R-induced increase of apoptotic rate and caspase-3 activity in H/R-treated cells.	Rutin	0-5	caspase 3	Rattus norvegicus	60-69
30691220-4	2019	This study aimed to validate the DPP-4 inhibitory activity of clerodane diterpene 16-hydroxycleroda-3,13-dien-15,16-olide (HCD) from Polyalthia longifolia, rutin, quercetin, and berberine, previously selected through molecular docking.	Rutin	156-161	dipeptidyl peptidase 4	Homo sapiens	33-38
30365940-0	2019	Rutin alleviates hypoxia/reoxygenation-induced injury in myocardial cells by up-regulating SIRT1 expression.	Rutin	0-5	sirtuin 1	Rattus norvegicus	91-96
30804434-10	2019	Furthermore, after oral administration of quercetin glycoside at 10 and 100 mg/kg body weight significantly induced GLUT4 translocation to the plasma membrane of skeletal muscles in mice.	Rutin	42-61	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	116-121
30781895-7	2019	However, the bran ethanol extract with high rutin content provided the most liver protection and anti-fibrosis effect via blocking the tumor necrosis factor alpha (TNF-alpha)/interleukin 6 (IL-6) pathway and transforming growth factor beta 1 (TGF-beta1) pathway.	Rutin	44-49	transforming growth factor, beta 1	Mus musculus	243-252
30529121-2	2019	In this study, the polyphenols from H. serotina (HSP) were mainly composed by caffeic acid dimer, (-)-epicatechin-3-(3"-o-methyl)-gallic acid dimer, quercetin-acetyl-rutinoside hexoside, (-)-epigallocatechin derivatives, rutin derivatives, catechin trimer and 3-caffeoylquinic acid.	Rutin	166-171	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	49-52
30099676-0	2019	Rutin protects against lipopolysaccharide-induced mastitis by inhibiting the activation of the NF-kappaB signaling pathway and attenuating endoplasmic reticulum stress.	Rutin	0-5	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-104
30099676-7	2019	Similarly, p50/p105, phosphorylated (p)-p65/p65 and p-inhibitor of nuclear factor kappa b kinase subunit beta (p-IKKbeta)/IKKbeta ratios in the LPS + rutin group (50 mg/kg) and LPS + rutin group (100 mg/kg) decreased significantly.	Rutin	150-155	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	11-14
30099676-7	2019	Similarly, p50/p105, phosphorylated (p)-p65/p65 and p-inhibitor of nuclear factor kappa b kinase subunit beta (p-IKKbeta)/IKKbeta ratios in the LPS + rutin group (50 mg/kg) and LPS + rutin group (100 mg/kg) decreased significantly.	Rutin	150-155	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	67-89
30099676-7	2019	Similarly, p50/p105, phosphorylated (p)-p65/p65 and p-inhibitor of nuclear factor kappa b kinase subunit beta (p-IKKbeta)/IKKbeta ratios in the LPS + rutin group (50 mg/kg) and LPS + rutin group (100 mg/kg) decreased significantly.	Rutin	150-155	inhibitor of kappaB kinase beta	Mus musculus	113-120
30099676-7	2019	Similarly, p50/p105, phosphorylated (p)-p65/p65 and p-inhibitor of nuclear factor kappa b kinase subunit beta (p-IKKbeta)/IKKbeta ratios in the LPS + rutin group (50 mg/kg) and LPS + rutin group (100 mg/kg) decreased significantly.	Rutin	150-155	inhibitor of kappaB kinase beta	Mus musculus	122-129
30099676-8	2019	GRP78 protein expression was significantly higher in LPS + rutin group (100 mg/kg).	Rutin	59-64	heat shock protein 5	Mus musculus	0-5
30099676-10	2019	The nuclear quantity of p65 in the LPS + rutin group decreased significantly in a rutin dose-dependent manner.	Rutin	41-46	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	24-27
30099676-10	2019	The nuclear quantity of p65 in the LPS + rutin group decreased significantly in a rutin dose-dependent manner.	Rutin	82-87	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	24-27
30212708-7	2018	The study showed that the high (100 muM) and low (100 nM and 10muM) rutin concentrations significantly avert ROS generation by two different mechanisms, by enhancing apoptosis through the modulation of levels of Bcl2, Caspase-3, survivin and its antioxidant activity via stress-related proteins, JNK and p38 MAPK.	Rutin	68-73	BCL2 apoptosis regulator	Homo sapiens	212-216
30412832-0	2019	Novel glucopyranoside C2-derived 1,2,3-triazoles displaying selective inhibition of O-GlcNAcase (OGA).	Rutin	6-21	O-GlcNAcase	Homo sapiens	84-95
30412832-0	2019	Novel glucopyranoside C2-derived 1,2,3-triazoles displaying selective inhibition of O-GlcNAcase (OGA).	Rutin	6-21	O-GlcNAcase	Homo sapiens	97-100
30412832-4	2019	However, many of the inhibitors lack selectivity for OGA over lysosomal hexosaminidases A and B. Aiming the selectively inhibition of OGA, we propose herein the synthesis of twelve novel glucopyranoside derivatives exploring the bioisosteric replacement of the GlcNAc 2-acetamide group by 1,4-disubstituted 1,2,3-triazole ring, bearing a variety of central chains with different shapes.	Rutin	187-202	O-GlcNAcase	Homo sapiens	134-137
30397060-5	2019	Rutin also significantly attenuated VCM-induced oxidative stress, inflammatory cell infiltration, apoptosis, and decreased interleukin-1beta and tumor necrosis factor alpha levels (all P < 0.05 or 0.01) in kidneys.	Rutin	0-5	interleukin 1 beta	Rattus norvegicus	123-140
30397060-5	2019	Rutin also significantly attenuated VCM-induced oxidative stress, inflammatory cell infiltration, apoptosis, and decreased interleukin-1beta and tumor necrosis factor alpha levels (all P < 0.05 or 0.01) in kidneys.	Rutin	0-5	tumor necrosis factor	Rattus norvegicus	145-172
30720195-10	2019	The most remarkable alteration was observed in the dHSL gene encoding a lipase involved in lipid-storage after HFD feeding and HFD with QG or EGCG.	Rutin	136-138	Hormone-sensitive lipase	Drosophila melanogaster	51-55
30372836-8	2018	Over-expression of ACE, TGF-beta1 and decreased podocin expression in diabetic rats was significantly reversed in rats administered with both ramipril and rutin.	Rutin	155-160	angiotensin I converting enzyme	Rattus norvegicus	19-22
30372836-8	2018	Over-expression of ACE, TGF-beta1 and decreased podocin expression in diabetic rats was significantly reversed in rats administered with both ramipril and rutin.	Rutin	155-160	transforming growth factor, beta 1	Rattus norvegicus	24-33
30372836-8	2018	Over-expression of ACE, TGF-beta1 and decreased podocin expression in diabetic rats was significantly reversed in rats administered with both ramipril and rutin.	Rutin	155-160	NPHS2 stomatin family member, podocin	Rattus norvegicus	48-55
30212708-7	2018	The study showed that the high (100 muM) and low (100 nM and 10muM) rutin concentrations significantly avert ROS generation by two different mechanisms, by enhancing apoptosis through the modulation of levels of Bcl2, Caspase-3, survivin and its antioxidant activity via stress-related proteins, JNK and p38 MAPK.	Rutin	68-73	caspase 3	Homo sapiens	218-227
30259632-0	2018	Ameliorative effect of Rutin on sodium fluoride-induced hypertension through modulation of Kim-1/NF-kappaB/Nrf2 signaling pathway in rats.	Rutin	23-28	hepatitis A virus cellular receptor 1	Rattus norvegicus	91-96
30259632-0	2018	Ameliorative effect of Rutin on sodium fluoride-induced hypertension through modulation of Kim-1/NF-kappaB/Nrf2 signaling pathway in rats.	Rutin	23-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	107-111
29183268-7	2018	Taken together, this result suggests that rutin is a potential mTOR inhibitor in screen hits of molecular docking to hamper the activation of HSC and further applications in the treatment of liver fibrosis.	Rutin	42-47	mechanistic target of rapamycin kinase	Homo sapiens	63-67
30477461-4	2018	The binding interaction of flavonoids (theaflavin, quercetin, rutin, epicatechin 3 gallate and tamarixetin) with GSK 3beta was determined by molecular docking.	Rutin	62-67	glycogen synthase kinase 3 beta	Homo sapiens	113-122
30455677-6	2018	Compared to the rutin supplementation alone, the co-administration of rutin with inulin improved the utilization of rutin as indicated by its decreased excretion, suppressed a number of harmful bacteria including Deferribacteraceae and Desulfovibrionaceae (p &lt; 0.05), and further reduced the expression of the key inflammatory cytokine TNF-alpha and increased the production of butyrate, despite the supplementation of inulin reversed the decrease of body weight induced by rutin supplementation due to an increased food intake.	Rutin	70-75	tumor necrosis factor	Mus musculus	339-348
30455677-6	2018	Compared to the rutin supplementation alone, the co-administration of rutin with inulin improved the utilization of rutin as indicated by its decreased excretion, suppressed a number of harmful bacteria including Deferribacteraceae and Desulfovibrionaceae (p &lt; 0.05), and further reduced the expression of the key inflammatory cytokine TNF-alpha and increased the production of butyrate, despite the supplementation of inulin reversed the decrease of body weight induced by rutin supplementation due to an increased food intake.	Rutin	70-75	tumor necrosis factor	Mus musculus	339-348
30138894-8	2018	Rutin could reduce the ALT, AST activities and AGEs level in serum and potentiate the expression of IRS-2, P-PI3K (p85), P-Akt (Ser473), P-GSK-3beta (Ser9) protein and IRS-2 mRNA in the liver tissue of db/db mice.	Rutin	0-5	glutamic pyruvic transaminase, soluble	Mus musculus	23-26
30308277-2	2018	Currently, there is a growing interest in the photoprotector and antioxidant potential of bioactive substances, such as rutin, that could increase the sun protection factor (SPF) value and, also, donate multifunctional characteristics to sunscreens.	Rutin	120-125	SEC14 like lipid binding 2	Homo sapiens	174-177
30308277-3	2018	Recent in vitro findings indicated that rutin, when incorporated into sunscreens, can provide antioxidant activity and SPF improvement.	Rutin	40-45	SEC14 like lipid binding 2	Homo sapiens	119-122
30308277-5	2018	We aimed at evaluating the clinical safety and in vivo SPF of rutin by comparing sunscreen formulations containing 0.1% (w/w) rutin, 3.0% (w/w) butyl methoxydibenzoylmethane and 8.0% (w/w) octyl dimethyl PABA (2-ethylhexyl 4-(dimethylamino)benzoato) with a similar bioactive-free preparation.	Rutin	62-67	SEC14 like lipid binding 2	Homo sapiens	55-58
30308277-10	2018	To date, this is the first report in the specialized literature of an in vivo SPF measurement of a rutin-containing photoprotective preparation, supporting the claim that rutin is an effective and safe bioactive compound to be used in multifunctional sunscreens.	Rutin	99-104	SEC14 like lipid binding 2	Homo sapiens	78-81
30308277-10	2018	To date, this is the first report in the specialized literature of an in vivo SPF measurement of a rutin-containing photoprotective preparation, supporting the claim that rutin is an effective and safe bioactive compound to be used in multifunctional sunscreens.	Rutin	171-176	SEC14 like lipid binding 2	Homo sapiens	78-81
30257364-6	2018	Furthermore, administration of QA and RU in PAR-induced rats modulated the key enzymes relevant to erection, improved antioxidant status and could be potential functional food ingredients and nutraceuticals in the prevention and/or management of erectile dysfunction.	Rutin	38-40	plasminogen activator, urokinase receptor	Rattus norvegicus	44-47
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	Rutin	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-45
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	Rutin	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	Rutin	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	Rutin	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
30048725-3	2018	Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE.	Rutin	77-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-45
30048725-5	2018	Forsythiaside and rutin show some properties in common, including the stoichiometric binding ratio of 1:1 with AChE and the full quenching of AChE fluorescence.	Rutin	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	111-115
30048725-5	2018	Forsythiaside and rutin show some properties in common, including the stoichiometric binding ratio of 1:1 with AChE and the full quenching of AChE fluorescence.	Rutin	18-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-146
30048725-6	2018	At the same time, the two compounds distinctly present some different characters, for example, the binding constant of rutin is less than that of forsythiaside, and the interaction force and the affinity between forsythiaside and AChE are much bigger than that of rutin.	Rutin	119-124	acetylcholinesterase (Cartwright blood group)	Homo sapiens	230-234
30138894-8	2018	Rutin could reduce the ALT, AST activities and AGEs level in serum and potentiate the expression of IRS-2, P-PI3K (p85), P-Akt (Ser473), P-GSK-3beta (Ser9) protein and IRS-2 mRNA in the liver tissue of db/db mice.	Rutin	0-5	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	28-31
30138894-8	2018	Rutin could reduce the ALT, AST activities and AGEs level in serum and potentiate the expression of IRS-2, P-PI3K (p85), P-Akt (Ser473), P-GSK-3beta (Ser9) protein and IRS-2 mRNA in the liver tissue of db/db mice.	Rutin	0-5	insulin receptor substrate 2	Mus musculus	100-105
30138894-8	2018	Rutin could reduce the ALT, AST activities and AGEs level in serum and potentiate the expression of IRS-2, P-PI3K (p85), P-Akt (Ser473), P-GSK-3beta (Ser9) protein and IRS-2 mRNA in the liver tissue of db/db mice.	Rutin	0-5	extracellular matrix protein 1	Mus musculus	115-118
30138894-8	2018	Rutin could reduce the ALT, AST activities and AGEs level in serum and potentiate the expression of IRS-2, P-PI3K (p85), P-Akt (Ser473), P-GSK-3beta (Ser9) protein and IRS-2 mRNA in the liver tissue of db/db mice.	Rutin	0-5	thymoma viral proto-oncogene 1	Mus musculus	123-126
30138894-8	2018	Rutin could reduce the ALT, AST activities and AGEs level in serum and potentiate the expression of IRS-2, P-PI3K (p85), P-Akt (Ser473), P-GSK-3beta (Ser9) protein and IRS-2 mRNA in the liver tissue of db/db mice.	Rutin	0-5	insulin receptor substrate 2	Mus musculus	168-173
30138894-11	2018	In general, the protective effect of rutin on the liver of T2DM may be mediated by facilitating signal transduction and activated state of insulin IRS-2/PI3K/Akt/GSK-3beta signal pathway, promoting hepatocyte proliferation, reducing blood glucose level and generation of AGEs.	Rutin	37-42	insulin receptor substrate 2	Mus musculus	147-152
30138894-11	2018	In general, the protective effect of rutin on the liver of T2DM may be mediated by facilitating signal transduction and activated state of insulin IRS-2/PI3K/Akt/GSK-3beta signal pathway, promoting hepatocyte proliferation, reducing blood glucose level and generation of AGEs.	Rutin	37-42	thymoma viral proto-oncogene 1	Mus musculus	158-161
30138894-11	2018	In general, the protective effect of rutin on the liver of T2DM may be mediated by facilitating signal transduction and activated state of insulin IRS-2/PI3K/Akt/GSK-3beta signal pathway, promoting hepatocyte proliferation, reducing blood glucose level and generation of AGEs.	Rutin	37-42	glycogen synthase kinase 3 beta	Mus musculus	162-171
30189596-6	2018	Taken altogether, in vitro and in vivo experiments suggest that selected natural compounds (curcumin, antroquinonol, HCD, docosanol, tetracosanol, rutin, and actinodaphnine) via molecular docking were confirmed as potential candidates of alpha-glucosidase and alpha-amylase inhibitors for treating diabetes.	Rutin	147-152	sucrase isomaltase (alpha-glucosidase)	Mus musculus	238-255
30231045-6	2018	These results confirmed that rutin derivatives have antioxidant potential, as evaluated by the ORAC method (rutin standard: 0.53 +- 0.08 muM Trolox/g and rutin derivatives: 2.33 +- 1.08 muM Trolox/g) and also show low cytotoxicity in human and animal cells.	Rutin	29-34	latexin	Homo sapiens	137-140
30231045-6	2018	These results confirmed that rutin derivatives have antioxidant potential, as evaluated by the ORAC method (rutin standard: 0.53 +- 0.08 muM Trolox/g and rutin derivatives: 2.33 +- 1.08 muM Trolox/g) and also show low cytotoxicity in human and animal cells.	Rutin	29-34	latexin	Homo sapiens	186-189
29455557-7	2018	Regarding these parameters, in CIS group MDA, MPO, IL1beta and TNF-alpha levels were statistically significantly increased with cisplatin administration and giving rutin concomitantly with cisplatin prevented this increase.	Rutin	164-169	myeloperoxidase	Rattus norvegicus	46-49
29455557-7	2018	Regarding these parameters, in CIS group MDA, MPO, IL1beta and TNF-alpha levels were statistically significantly increased with cisplatin administration and giving rutin concomitantly with cisplatin prevented this increase.	Rutin	164-169	tumor necrosis factor	Rattus norvegicus	63-72
28906145-0	2018	Protective effect of rutin against brain injury induced by acrylamide or gamma radiation: role of PI3K/AKT/GSK-3beta/NRF-2 signalling pathway.	Rutin	21-26	AKT serine/threonine kinase 1	Homo sapiens	103-106
30181695-0	2018	Influence of rutin on the effects of neonatal cigarette smoke exposure-induced exacerbated MMP-9 expression, Th17 cytokines and NF-kappaB/iNOS-mediated inflammatory responses in asthmatic mice model.	Rutin	13-18	matrix metallopeptidase 9	Mus musculus	91-96
29920283-0	2018	Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1.	Rutin	0-5	sirtuin 1	Mus musculus	159-164
29702339-1	2018	The binding interaction of Rutin, a flavonoid, with model transport proteins, bovine serum albumin (BSA) and human serum albumin (HSA), were investigated using different spectroscopic techniques, such as fluorescence, time-resolved single photon counting (TCSPC) and circular dichroism (CD) spectroscopy as well as molecular docking method.	Rutin	27-32	albumin	Homo sapiens	85-104
29702339-1	2018	The binding interaction of Rutin, a flavonoid, with model transport proteins, bovine serum albumin (BSA) and human serum albumin (HSA), were investigated using different spectroscopic techniques, such as fluorescence, time-resolved single photon counting (TCSPC) and circular dichroism (CD) spectroscopy as well as molecular docking method.	Rutin	27-32	albumin	Homo sapiens	85-98
29702339-2	2018	The emission studies revealed that the fluorescence quenching of BSA/HSA by Rutin occurred through a simultaneous static and dynamic quenching process, and we have evaluated both the quenching constants individually.	Rutin	76-81	albumin	Homo sapiens	65-68
29702339-4	2018	Further, influence of some biologically significant metal ions (Ca2+, Zn2+ and Mg2+) on binding of Rutin to BSA and HSA were also investigated.	Rutin	99-104	albumin	Homo sapiens	108-111
29702339-5	2018	Thermodynamic parameters justified the involvement of hydrogen bonding and weak van der Waals forces in the interaction of Rutin with both BSA and HSA.	Rutin	123-128	albumin	Homo sapiens	139-142
29702339-7	2018	Additionally, the CD spectra of BSA and HSA revealed that the secondary structure of the proteins was perturbed in the presence of Rutin.	Rutin	131-136	albumin	Homo sapiens	32-35
29512831-8	2018	Quercetin or rutin co-treatment with SASP significantly reversed organ weights, preserved sperm integrity, restored plasma hormone levels and increased cholesterol levels, 3beta-HSD and 17beta-HSD activities in testis.	Rutin	13-18	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	172-181
29512831-8	2018	Quercetin or rutin co-treatment with SASP significantly reversed organ weights, preserved sperm integrity, restored plasma hormone levels and increased cholesterol levels, 3beta-HSD and 17beta-HSD activities in testis.	Rutin	13-18	aldo-keto reductase family 1, member C12	Rattus norvegicus	186-196
29368407-5	2018	In TSLP-stimulated cells, rutin or HM0601 treatment significantly impaired levels of interleukin (IL)-13 and Bcl2 expression.	Rutin	26-31	thymic stromal lymphopoietin	Homo sapiens	3-7
29368407-5	2018	In TSLP-stimulated cells, rutin or HM0601 treatment significantly impaired levels of interleukin (IL)-13 and Bcl2 expression.	Rutin	26-31	BCL2 apoptosis regulator	Homo sapiens	109-113
29094308-0	2018	Ameliorative potential of rutin in combination with nimesulide in STZ model of diabetic neuropathy: targeting Nrf2/HO-1/NF-kB and COX signalling pathway.	Rutin	26-31	NFE2 like bZIP transcription factor 2	Rattus norvegicus	110-114
29094308-0	2018	Ameliorative potential of rutin in combination with nimesulide in STZ model of diabetic neuropathy: targeting Nrf2/HO-1/NF-kB and COX signalling pathway.	Rutin	26-31	heme oxygenase 1	Rattus norvegicus	115-119
29094308-0	2018	Ameliorative potential of rutin in combination with nimesulide in STZ model of diabetic neuropathy: targeting Nrf2/HO-1/NF-kB and COX signalling pathway.	Rutin	26-31	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-125
29094308-14	2018	The present study suggests the involvement of Nrf-2/HO-1 pathway in the protective effect of rutin against streptozotocin-induced diabetic neuropathy.	Rutin	93-98	NFE2 like bZIP transcription factor 2	Rattus norvegicus	46-51
29094308-14	2018	The present study suggests the involvement of Nrf-2/HO-1 pathway in the protective effect of rutin against streptozotocin-induced diabetic neuropathy.	Rutin	93-98	heme oxygenase 1	Rattus norvegicus	52-56
29679855-0	2018	Rutin and rutin-conjugated gold nanoparticles ameliorate collagen-induced arthritis in rats through inhibition of NF-kappaB and iNOS activation.	Rutin	0-5	nuclear factor kappa B subunit 1	Homo sapiens	114-123
29679855-0	2018	Rutin and rutin-conjugated gold nanoparticles ameliorate collagen-induced arthritis in rats through inhibition of NF-kappaB and iNOS activation.	Rutin	0-5	nitric oxide synthase 2	Rattus norvegicus	128-132
29679855-0	2018	Rutin and rutin-conjugated gold nanoparticles ameliorate collagen-induced arthritis in rats through inhibition of NF-kappaB and iNOS activation.	Rutin	10-15	nuclear factor kappa B subunit 1	Homo sapiens	114-123
29679855-0	2018	Rutin and rutin-conjugated gold nanoparticles ameliorate collagen-induced arthritis in rats through inhibition of NF-kappaB and iNOS activation.	Rutin	10-15	nitric oxide synthase 2	Rattus norvegicus	128-132
29679855-4	2018	The aim of the present study was to investigate the anti-arthritic mechanism of bioflavonoids, rutin and rutin-conjugated gold nanoparticles (R-AuNPs) by determining their role in the modulation of NF-kappaB and iNOS expression in collagen-induced arthritis (CIA) model of rats.	Rutin	105-110	nuclear factor kappa B subunit 1	Homo sapiens	198-207
29679855-4	2018	The aim of the present study was to investigate the anti-arthritic mechanism of bioflavonoids, rutin and rutin-conjugated gold nanoparticles (R-AuNPs) by determining their role in the modulation of NF-kappaB and iNOS expression in collagen-induced arthritis (CIA) model of rats.	Rutin	105-110	nitric oxide synthase 2	Rattus norvegicus	212-216
28906145-0	2018	Protective effect of rutin against brain injury induced by acrylamide or gamma radiation: role of PI3K/AKT/GSK-3beta/NRF-2 signalling pathway.	Rutin	21-26	glycogen synthase kinase 3 beta	Homo sapiens	107-116
28906145-0	2018	Protective effect of rutin against brain injury induced by acrylamide or gamma radiation: role of PI3K/AKT/GSK-3beta/NRF-2 signalling pathway.	Rutin	21-26	NFE2 like bZIP transcription factor 2	Homo sapiens	117-122
28906145-6	2018	It could be concluded that rutin provides protection effect against acrylamide or gamma-radiation-induced neurotoxicity via activation of the PI3K/AKT/GSK-3beta/NRF-2-pathway by altering the phosphorylation state through its ability to scavenge free radicals generation, modulating gene expression and its anti-inflammatory effects.	Rutin	27-32	AKT serine/threonine kinase 1	Homo sapiens	147-150
28906145-6	2018	It could be concluded that rutin provides protection effect against acrylamide or gamma-radiation-induced neurotoxicity via activation of the PI3K/AKT/GSK-3beta/NRF-2-pathway by altering the phosphorylation state through its ability to scavenge free radicals generation, modulating gene expression and its anti-inflammatory effects.	Rutin	27-32	glycogen synthase kinase 3 beta	Homo sapiens	151-160
28906145-6	2018	It could be concluded that rutin provides protection effect against acrylamide or gamma-radiation-induced neurotoxicity via activation of the PI3K/AKT/GSK-3beta/NRF-2-pathway by altering the phosphorylation state through its ability to scavenge free radicals generation, modulating gene expression and its anti-inflammatory effects.	Rutin	27-32	NFE2 like bZIP transcription factor 2	Homo sapiens	161-166
30014639-11	2018	Compared to the DM group,the levels of blood glucose were lower (P&lt;0.05) at 4 weeks and 8 weeks,the contents of ALT,AST and LDH were significantly decreased,and TP and ALB were improved in both Rutin dose group.	Rutin	197-202	glutamic pyruvic transaminase, soluble	Mus musculus	115-118
30014639-11	2018	Compared to the DM group,the levels of blood glucose were lower (P&lt;0.05) at 4 weeks and 8 weeks,the contents of ALT,AST and LDH were significantly decreased,and TP and ALB were improved in both Rutin dose group.	Rutin	197-202	albumin	Mus musculus	171-174
29522708-0	2018	Protective effect of rutin against carbon tetrachloride-induced oxidative stress, inflammation and apoptosis in mouse kidney associated with the ceramide, MAPKs, p53 and calpain activities.	Rutin	21-26	transformation related protein 53, pseudogene	Mus musculus	162-165
29522708-10	2018	Taken together, rutin ameliorates CCl4-induced oxidative stress, inflammation and apoptosis through regulating the ceramide, MAPK, p53 and calpain activities and thereby suppressing apoptosis by the mitochondrial pathway.	Rutin	16-21	chemokine (C-C motif) ligand 4	Mus musculus	34-38
29522708-10	2018	Taken together, rutin ameliorates CCl4-induced oxidative stress, inflammation and apoptosis through regulating the ceramide, MAPK, p53 and calpain activities and thereby suppressing apoptosis by the mitochondrial pathway.	Rutin	16-21	transformation related protein 53, pseudogene	Mus musculus	131-134
29281744-6	2018	Administration of GbE, rutin and quercetin remarkably inhibited the AR activity, stimulated the production of glutathione, and decreased the levels of MDA and AGEs in the lenses of DC-induced rats, which eventually delayed the progression of lens opacification in diabetic rats to various degrees.	Rutin	23-28	aldo-keto reductase family 1 member B1	Rattus norvegicus	68-70
29078725-3	2018	Treatment with rutin and dexrazoxane resulted in an increase in Bcl-2/Bax ratio (p &lt; 0.05) and reduction in JNK and Caspase-3 protein levels, compared to the pirarubicin group (all p &lt; 0.05).	Rutin	15-20	BCL2, apoptosis regulator	Rattus norvegicus	64-69
29078725-3	2018	Treatment with rutin and dexrazoxane resulted in an increase in Bcl-2/Bax ratio (p &lt; 0.05) and reduction in JNK and Caspase-3 protein levels, compared to the pirarubicin group (all p &lt; 0.05).	Rutin	15-20	BCL2 associated X, apoptosis regulator	Rattus norvegicus	70-73
29078725-3	2018	Treatment with rutin and dexrazoxane resulted in an increase in Bcl-2/Bax ratio (p &lt; 0.05) and reduction in JNK and Caspase-3 protein levels, compared to the pirarubicin group (all p &lt; 0.05).	Rutin	15-20	mitogen-activated protein kinase 8	Rattus norvegicus	111-114
29078725-3	2018	Treatment with rutin and dexrazoxane resulted in an increase in Bcl-2/Bax ratio (p &lt; 0.05) and reduction in JNK and Caspase-3 protein levels, compared to the pirarubicin group (all p &lt; 0.05).	Rutin	15-20	caspase 3	Rattus norvegicus	119-128
28946364-3	2018	Upon removal of GuHCl from SSF, a rutin encapsulation ratio of 10.1% was obtained; and the prepared rutin-loaded ferritin nanoparticles were homogeneously distributed, showing a shell-like morphology with a size of 12nm.	Rutin	100-105	ferritin-1, chloroplastic	Glycine max	113-121
29315975-0	2018	Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity.	Rutin	0-5	sorbitol dehydrogenase	Mus musculus	66-88
28369959-2	2017	RESULTS: Gallic acid, ferulic acid, and rutin were widely present in these flowers, which demonstrated various antioxidant capacities (DPPH, ABTS, FRAP and CAA values) and antiproliferative potentials measured by the MTT method.	Rutin	40-45	mechanistic target of rapamycin kinase	Homo sapiens	147-151
29180336-8	2017	The expression levels of Ucp1 mRNA and protein increased (P&lt;0.05) and the expressions of Mcp1 and TNF-alpha decreased significantly in the mice after rutin treatment (P&lt;0.05).	Rutin	153-158	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	25-29
29180336-8	2017	The expression levels of Ucp1 mRNA and protein increased (P&lt;0.05) and the expressions of Mcp1 and TNF-alpha decreased significantly in the mice after rutin treatment (P&lt;0.05).	Rutin	153-158	mast cell protease 1	Mus musculus	92-96
29180336-8	2017	The expression levels of Ucp1 mRNA and protein increased (P&lt;0.05) and the expressions of Mcp1 and TNF-alpha decreased significantly in the mice after rutin treatment (P&lt;0.05).	Rutin	153-158	tumor necrosis factor	Mus musculus	101-110
28743028-1	2017	Herein, a sensitive photo-electrochemical sensor based on C3N4 and reduced graphene oxide nanosheets modified glassy carbon electrode (C3N4-RGO/GCE) has been fabricated for the detection of rutin under UV light illumination.	Rutin	190-195	glycine decarboxylase	Homo sapiens	135-147
29300762-10	2018	These activities of drugs were compared with the anti-glycation activity of the standard, rutin (IC50 = 294.5 +- 1.50 muM in BSA-MG glycation model, and IC50 = 86.94 +- 0.24 muM in BSA- glucose model).	Rutin	90-95	latexin	Homo sapiens	118-121
29250160-0	2018	Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model.	Rutin	0-5	mitogen-activated protein kinase 3	Sus scrofa	46-52
29250160-0	2018	Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model.	Rutin	0-5	AKT serine/threonine kinase 1	Sus scrofa	57-60
29250160-2	2018	The present study aimed to investigate whether rutin inhibits coronary heart disease through extracellular signal-regulated kinase (ERK) 1/2 and Akt signaling in a porcine model.	Rutin	47-52	mitogen-activated protein kinase 3	Sus scrofa	93-140
29250160-2	2018	The present study aimed to investigate whether rutin inhibits coronary heart disease through extracellular signal-regulated kinase (ERK) 1/2 and Akt signaling in a porcine model.	Rutin	47-52	AKT serine/threonine kinase 1	Sus scrofa	145-148
29250160-7	2018	The present study suggests that rutin inhibits coronary heart disease through ERK1/2 and Akt signaling pathways in a porcine model.	Rutin	32-37	mitogen-activated protein kinase 3	Sus scrofa	78-84
29250160-7	2018	The present study suggests that rutin inhibits coronary heart disease through ERK1/2 and Akt signaling pathways in a porcine model.	Rutin	32-37	AKT serine/threonine kinase 1	Sus scrofa	89-92
28672902-5	2017	Additionally, DAPI staining revealed that the number of apoptotic cells was higher in the rutin and cisplatin groups compared with the control group, and immunofluorescence showed that the expression of GSK-3beta in the cisplatin and rutin groups was significantly higher compared with that in the control group.	Rutin	90-95	glycogen synthase kinase 3 beta	Homo sapiens	203-212
29023372-10	2017	Glycosyl flavonoids, isoquercetin and rutin as well as naringin showed selective cytotoxicity to BRCA2-deficient cells; hesperidin did not.	Rutin	38-43	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	97-102
28752532-2	2017	In this study, the flavonoid rutin (quercetin 3-O-beta-d-rutinoside) was investigated as chemosensitizer towards two different human epithelial breast cancer cell lines: (i) MB-MDA-231, selected as representative for triple-negative breast cancer and (ii) MCF-7 used as a well-characterized model of HER2-negative breast cancer.	Rutin	29-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	300-304
28752532-4	2017	In MDA-MB-231 cells, 20 muM rutin enhanced cytotoxicity related to cyclophosphamide and methotrexate.	Rutin	28-33	latexin	Homo sapiens	24-27
28752532-7	2017	Rutin, via non-selective inhibition of P-gp and BCRP pumps, efficiently reverses multidrug resistance and restores chemosensitivity to cyclophosphamide and cyclophosphamide of human chemoresistant, triple-negative breast cancer cells, successfully arresting cell cycle progression.	Rutin	0-5	ATP binding cassette subfamily B member 1	Homo sapiens	39-43
28752532-7	2017	Rutin, via non-selective inhibition of P-gp and BCRP pumps, efficiently reverses multidrug resistance and restores chemosensitivity to cyclophosphamide and cyclophosphamide of human chemoresistant, triple-negative breast cancer cells, successfully arresting cell cycle progression.	Rutin	0-5	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	48-52
28700826-4	2017	Compared with other published carbon materials modified sensors, the annealed coal/chitosan/GCE sensor exhibited excellent electrocatalytic activity for the determination of rutin with good sensitivity, providing a wide linear detection range from 0.001 to 10 mumol dm-3 and a low detection limit of 0.2 nmol dm-3 (S/N = 3).	Rutin	174-179	aminomethyltransferase	Homo sapiens	92-95
28619064-13	2017	CONCLUSION: The present study suggested that the anti-oxidant and anti-inflammatory effect of rutin may prevent CP-induced nephrotoxicity via decreasing the oxidative stress, inhibiting the interconnected ROS/JNK/TNF/P38 MAPK signaling pathways, and repairing the histopathological changes against cisplatin administration.	Rutin	94-99	mitogen-activated protein kinase 8	Rattus norvegicus	209-212
28619064-13	2017	CONCLUSION: The present study suggested that the anti-oxidant and anti-inflammatory effect of rutin may prevent CP-induced nephrotoxicity via decreasing the oxidative stress, inhibiting the interconnected ROS/JNK/TNF/P38 MAPK signaling pathways, and repairing the histopathological changes against cisplatin administration.	Rutin	94-99	tumor necrosis factor	Rattus norvegicus	213-216
28619064-13	2017	CONCLUSION: The present study suggested that the anti-oxidant and anti-inflammatory effect of rutin may prevent CP-induced nephrotoxicity via decreasing the oxidative stress, inhibiting the interconnected ROS/JNK/TNF/P38 MAPK signaling pathways, and repairing the histopathological changes against cisplatin administration.	Rutin	94-99	mitogen activated protein kinase 14	Rattus norvegicus	217-220
28620169-3	2017	In present study, we have performed detailed biophysical studies for the interaction of human c-myc G-quadruplex DNA with nine representative flavonoids: Luteolin, Quercetin, Rutin, Genistein, Kaempferol, Puerarin, Hesperidin, Myricetin and Daidzein.	Rutin	175-180	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	94-99
31682386-7	2017	Among which, nearly 90% of them were identified as baicalin and rutin with PLSR and HPLC-DAD-ESI-MSn.	Rutin	64-69	moesin	Rattus norvegicus	97-100
28374530-0	2017	Binding of fluphenazine with human serum albumin in the presence of rutin and quercetin: An evaluation of food-drug interaction by spectroscopic techniques.	Rutin	68-73	albumin	Homo sapiens	35-48
28693884-0	2017	The flavonoid rutin modulates microglial/macrophage activation to a CD150/CD206 M2 phenotype.	Rutin	14-19	signaling lymphocytic activation molecule family member 1	Mus musculus	68-73
28693884-0	2017	The flavonoid rutin modulates microglial/macrophage activation to a CD150/CD206 M2 phenotype.	Rutin	14-19	mannose receptor, C type 1	Mus musculus	74-79
28693884-6	2017	Rutin also induced microglial activation characterized by an increase in OX-42 positive cells and a large proportion of cells with a CD150/CD206-positive M2 phenotype.	Rutin	0-5	signaling lymphocytic activation molecule family member 1	Mus musculus	133-138
28693884-6	2017	Rutin also induced microglial activation characterized by an increase in OX-42 positive cells and a large proportion of cells with a CD150/CD206-positive M2 phenotype.	Rutin	0-5	mannose receptor, C type 1	Mus musculus	139-144
28693884-7	2017	Rutin also induced a decrease in the mRNA levels of TNF, IL1beta, IL6 and iNOS, reduced the production of IL6, TNF, and nitric oxide, and increased production of the M2 regulatory cytokine IL10 and arginase.	Rutin	0-5	tumor necrosis factor	Mus musculus	52-55
28693884-7	2017	Rutin also induced a decrease in the mRNA levels of TNF, IL1beta, IL6 and iNOS, reduced the production of IL6, TNF, and nitric oxide, and increased production of the M2 regulatory cytokine IL10 and arginase.	Rutin	0-5	interleukin 1 beta	Mus musculus	57-64
28693884-7	2017	Rutin also induced a decrease in the mRNA levels of TNF, IL1beta, IL6 and iNOS, reduced the production of IL6, TNF, and nitric oxide, and increased production of the M2 regulatory cytokine IL10 and arginase.	Rutin	0-5	interleukin 6	Mus musculus	66-69
28693884-7	2017	Rutin also induced a decrease in the mRNA levels of TNF, IL1beta, IL6 and iNOS, reduced the production of IL6, TNF, and nitric oxide, and increased production of the M2 regulatory cytokine IL10 and arginase.	Rutin	0-5	nitric oxide synthase 2, inducible	Mus musculus	74-78
28693884-7	2017	Rutin also induced a decrease in the mRNA levels of TNF, IL1beta, IL6 and iNOS, reduced the production of IL6, TNF, and nitric oxide, and increased production of the M2 regulatory cytokine IL10 and arginase.	Rutin	0-5	interleukin 6	Mus musculus	106-109
28693884-7	2017	Rutin also induced a decrease in the mRNA levels of TNF, IL1beta, IL6 and iNOS, reduced the production of IL6, TNF, and nitric oxide, and increased production of the M2 regulatory cytokine IL10 and arginase.	Rutin	0-5	tumor necrosis factor	Mus musculus	111-114
28693884-7	2017	Rutin also induced a decrease in the mRNA levels of TNF, IL1beta, IL6 and iNOS, reduced the production of IL6, TNF, and nitric oxide, and increased production of the M2 regulatory cytokine IL10 and arginase.	Rutin	0-5	interleukin 10	Mus musculus	189-193
28693884-8	2017	Rutin also significantly inhibited the LPS-induced expression of PTGS2, IL18 and TGFbeta mRNA.	Rutin	0-5	prostaglandin-endoperoxide synthase 2	Mus musculus	65-70
28693884-8	2017	Rutin also significantly inhibited the LPS-induced expression of PTGS2, IL18 and TGFbeta mRNA.	Rutin	0-5	interleukin 18	Mus musculus	72-76
28693884-8	2017	Rutin also significantly inhibited the LPS-induced expression of PTGS2, IL18 and TGFbeta mRNA.	Rutin	0-5	transforming growth factor, beta 1	Mus musculus	81-88
28842631-2	2017	In this study, we have evaluated different natural dietary polyphenolics including rutin, quercetin, ferulic acid, hesperidin, gallic acid and vanillin as MARK4 inhibitors.	Rutin	83-88	microtubule affinity regulating kinase 4	Homo sapiens	155-160
28842631-5	2017	We found that rutin and vanillin bind to MARK4 with a reasonably high affinity.	Rutin	14-19	microtubule affinity regulating kinase 4	Homo sapiens	41-46
28842631-7	2017	Cell proliferation, ROS quantification and Annexin-V staining studies are clearly providing sufficient evidences for the apoptotic potential of rutin and vanillin.	Rutin	144-149	annexin A5	Homo sapiens	43-52
28842631-8	2017	In conclusion, rutin and vanillin may be considered as potential inhibitors for MARK4 and further exploited to design novel therapeutic molecules against MARK4 associated diseases.	Rutin	15-20	microtubule affinity regulating kinase 4	Homo sapiens	80-85
28842631-8	2017	In conclusion, rutin and vanillin may be considered as potential inhibitors for MARK4 and further exploited to design novel therapeutic molecules against MARK4 associated diseases.	Rutin	15-20	microtubule affinity regulating kinase 4	Homo sapiens	154-159
28577437-12	2017	In addition, rutin was shown to repress the autophagic function of liver tissues by down-regulating key autophagy biomarkers, including tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta).	Rutin	13-18	tumor necrosis factor	Mus musculus	136-163
28577437-12	2017	In addition, rutin was shown to repress the autophagic function of liver tissues by down-regulating key autophagy biomarkers, including tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta).	Rutin	13-18	tumor necrosis factor	Mus musculus	165-174
28577437-12	2017	In addition, rutin was shown to repress the autophagic function of liver tissues by down-regulating key autophagy biomarkers, including tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta).	Rutin	13-18	interleukin 1 beta	Mus musculus	177-195
28577437-12	2017	In addition, rutin was shown to repress the autophagic function of liver tissues by down-regulating key autophagy biomarkers, including tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta).	Rutin	13-18	interleukin 1 beta	Mus musculus	197-205
28672912-7	2017	Rutin may inhibit the expression of ACTA2 and p38 and may be utilized in the prevention and treatment of DN.	Rutin	0-5	actin alpha 2, smooth muscle	Homo sapiens	36-41
28672912-7	2017	Rutin may inhibit the expression of ACTA2 and p38 and may be utilized in the prevention and treatment of DN.	Rutin	0-5	mitogen-activated protein kinase 14	Homo sapiens	46-49
28672902-5	2017	Additionally, DAPI staining revealed that the number of apoptotic cells was higher in the rutin and cisplatin groups compared with the control group, and immunofluorescence showed that the expression of GSK-3beta in the cisplatin and rutin groups was significantly higher compared with that in the control group.	Rutin	234-239	glycogen synthase kinase 3 beta	Homo sapiens	203-212
28672902-6	2017	The results of the present study suggest that rutin promotes the TNF-alpha-induced apoptosis of A549 human lung carcinoma cells.	Rutin	46-51	tumor necrosis factor	Homo sapiens	65-74
28672912-0	2017	Rutin suppresses high glucose-induced ACTA2 and p38 protein expression in diabetic nephropathy.	Rutin	0-5	actin alpha 2, smooth muscle	Homo sapiens	38-43
28672912-0	2017	Rutin suppresses high glucose-induced ACTA2 and p38 protein expression in diabetic nephropathy.	Rutin	0-5	mitogen-activated protein kinase 14	Homo sapiens	48-51
28126675-6	2017	The activities of superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD) were remarkably increased by rutin treatment with concentrations of 20 and 40mumol/L, but glutathione peroxidase (GSH-Px) activity was notably decreased.	Rutin	111-116	catalase	Homo sapiens	46-54
28286015-8	2017	LC-MS/MS analysis indicated that rutin quinone targets cysteine 151 of Keap1.	Rutin	33-38	kelch like ECH associated protein 1	Homo sapiens	71-76
28565808-0	2017	Rutin attenuates isoflurane-induced neuroapoptosis via modulating JNK and p38 MAPK pathways in the hippocampi of neonatal rats.	Rutin	0-5	mitogen-activated protein kinase 8	Rattus norvegicus	66-69
28565808-0	2017	Rutin attenuates isoflurane-induced neuroapoptosis via modulating JNK and p38 MAPK pathways in the hippocampi of neonatal rats.	Rutin	0-5	mitogen activated protein kinase 14	Rattus norvegicus	74-77
28565808-11	2017	The expression levels of caspase-3, Bad, Bax and MAPK proteins, which were increased following isoflurane treatment, were rescued by rutin treatment.	Rutin	133-138	caspase 3	Rattus norvegicus	25-34
28565808-11	2017	The expression levels of caspase-3, Bad, Bax and MAPK proteins, which were increased following isoflurane treatment, were rescued by rutin treatment.	Rutin	133-138	BCL2 associated X, apoptosis regulator	Rattus norvegicus	41-44
28565808-11	2017	The expression levels of caspase-3, Bad, Bax and MAPK proteins, which were increased following isoflurane treatment, were rescued by rutin treatment.	Rutin	133-138	mitogen activated protein kinase 3	Rattus norvegicus	49-53
28565808-13	2017	Rutin provided neuroprotection against isoflurane-induced neuronal apoptosis and improved the learning and memory of rats by effectively regulating the expression levels of proteins in the MAPK pathway.	Rutin	0-5	mitogen activated protein kinase 3	Rattus norvegicus	189-193
28293765-6	2017	Moreover, immunoblotting analysis showed that TMZ activated JNK activity to induce protective response autophagy, which was blocked by rutin, resulting in decreased autophagy and increased apoptosis, suggesting that rutin enhances TMZ efficacy both in vitro and in vivo via inhibiting JNK-mediated autophagy in GBM.	Rutin	135-140	mitogen-activated protein kinase 8	Homo sapiens	60-63
28293765-6	2017	Moreover, immunoblotting analysis showed that TMZ activated JNK activity to induce protective response autophagy, which was blocked by rutin, resulting in decreased autophagy and increased apoptosis, suggesting that rutin enhances TMZ efficacy both in vitro and in vivo via inhibiting JNK-mediated autophagy in GBM.	Rutin	216-221	mitogen-activated protein kinase 8	Homo sapiens	60-63
28293765-6	2017	Moreover, immunoblotting analysis showed that TMZ activated JNK activity to induce protective response autophagy, which was blocked by rutin, resulting in decreased autophagy and increased apoptosis, suggesting that rutin enhances TMZ efficacy both in vitro and in vivo via inhibiting JNK-mediated autophagy in GBM.	Rutin	216-221	mitogen-activated protein kinase 8	Homo sapiens	285-288
28126675-6	2017	The activities of superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD) were remarkably increased by rutin treatment with concentrations of 20 and 40mumol/L, but glutathione peroxidase (GSH-Px) activity was notably decreased.	Rutin	111-116	catalase	Homo sapiens	56-59
28126675-8	2017	Furthermore, 20mumol/L rutin significantly abrogated the decrease in levels of phosphoinositide 3-kinase (PI3K) and phosphorylated serine/threonine kinase (p-AKT) induced by H2O2.	Rutin	23-28	AKT serine/threonine kinase 1	Homo sapiens	158-161
28049156-5	2017	Mechanistically, we found that rutin directly bound to and stabilized SIRT1, leading to hypoacetylation of peroxisome proliferator-activated receptor gamma coactivator-1alpha protein, which stimulated Tfam transactivation and eventually augmented the number of mitochondria and UCP1 activity in BAT.	Rutin	31-36	sirtuin 1	Mus musculus	70-75
28461719-2	2017	Further, to study the effect of most effective concentrations of gallic acid (60 microg mL-1) and rutin (50 microg mL-1), greenhouse pot experiment was set up to determine the changes in growth, antioxidant and defense parameters.	Rutin	98-103	L1 cell adhesion molecule	Mus musculus	115-119
28367221-0	2017	Rutin Protects against Pirarubicin-Induced Cardiotoxicity through TGF-beta1-p38 MAPK Signaling Pathway.	Rutin	0-5	transforming growth factor, beta 1	Rattus norvegicus	66-75
28392963-5	2017	In the present study, the effects of rutin on stimulus-induced NO and tumor necrosis factor (TNF)-alpha productions and MPO activity in human neutrophils were investigated.	Rutin	37-42	tumor necrosis factor	Homo sapiens	70-103
28392963-14	2017	CONCLUSION: In this in vitro study, rutin had an anti-inflammatory effect due to its inhibiting NO and TNF-alpha productions, as well as MPO activity, in activated human neutrophils.	Rutin	36-41	tumor necrosis factor	Homo sapiens	103-112
28392963-14	2017	CONCLUSION: In this in vitro study, rutin had an anti-inflammatory effect due to its inhibiting NO and TNF-alpha productions, as well as MPO activity, in activated human neutrophils.	Rutin	36-41	myeloperoxidase	Homo sapiens	137-140
27936392-11	2017	In vitro, expressions of TXNIP, NLRP3, and caspase-1 in aortic tissue of high glucose diet treated rats were decreased under rutin administration.	Rutin	125-130	thioredoxin interacting protein	Rattus norvegicus	25-30
27936392-11	2017	In vitro, expressions of TXNIP, NLRP3, and caspase-1 in aortic tissue of high glucose diet treated rats were decreased under rutin administration.	Rutin	125-130	NLR family, pyrin domain containing 3	Rattus norvegicus	32-37
27936392-11	2017	In vitro, expressions of TXNIP, NLRP3, and caspase-1 in aortic tissue of high glucose diet treated rats were decreased under rutin administration.	Rutin	125-130	caspase 1	Rattus norvegicus	43-52
27936392-12	2017	In summary, rutin may protect endothelial dysfunction through inhibiting Nox4 responsive oxidative stress and ROS-sensitive NLRP3 signaling pathway under high glucose stress both in vivo and vitro.	Rutin	12-17	NADPH oxidase 4	Rattus norvegicus	73-77
27936392-12	2017	In summary, rutin may protect endothelial dysfunction through inhibiting Nox4 responsive oxidative stress and ROS-sensitive NLRP3 signaling pathway under high glucose stress both in vivo and vitro.	Rutin	12-17	NLR family, pyrin domain containing 3	Rattus norvegicus	124-129
28049156-5	2017	Mechanistically, we found that rutin directly bound to and stabilized SIRT1, leading to hypoacetylation of peroxisome proliferator-activated receptor gamma coactivator-1alpha protein, which stimulated Tfam transactivation and eventually augmented the number of mitochondria and UCP1 activity in BAT.	Rutin	31-36	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	107-174
28049156-5	2017	Mechanistically, we found that rutin directly bound to and stabilized SIRT1, leading to hypoacetylation of peroxisome proliferator-activated receptor gamma coactivator-1alpha protein, which stimulated Tfam transactivation and eventually augmented the number of mitochondria and UCP1 activity in BAT.	Rutin	31-36	transcription factor A, mitochondrial	Mus musculus	201-205
28049156-5	2017	Mechanistically, we found that rutin directly bound to and stabilized SIRT1, leading to hypoacetylation of peroxisome proliferator-activated receptor gamma coactivator-1alpha protein, which stimulated Tfam transactivation and eventually augmented the number of mitochondria and UCP1 activity in BAT.	Rutin	31-36	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	278-282
27687881-6	2016	It was found that protocatechuic acid, chlorogenic acid, protocatechualdehyde, rutin, isoquercitrin, astragalin, and dicaffeoylquinic acid B had evident combination with lipase-linked magnetic microspheres.	Rutin	79-84	lipase, endothelial	Mus musculus	170-176
28467992-4	2017	Furthermore, the effect of rutin on the tumor necrosis factor-alpha and interleukin-1beta in arthritic rats showed does-dependent lowering of these cytokines with maximum benefit at 15 mg/kg dose and the level of both NF-kappaB p65 and NF-kappaBp65 (Ser536) has been significantly reduced in the presence of rutin.	Rutin	27-32	tumor necrosis factor	Rattus norvegicus	40-67
28467992-4	2017	Furthermore, the effect of rutin on the tumor necrosis factor-alpha and interleukin-1beta in arthritic rats showed does-dependent lowering of these cytokines with maximum benefit at 15 mg/kg dose and the level of both NF-kappaB p65 and NF-kappaBp65 (Ser536) has been significantly reduced in the presence of rutin.	Rutin	27-32	interleukin 1 beta	Rattus norvegicus	72-89
28467992-4	2017	Furthermore, the effect of rutin on the tumor necrosis factor-alpha and interleukin-1beta in arthritic rats showed does-dependent lowering of these cytokines with maximum benefit at 15 mg/kg dose and the level of both NF-kappaB p65 and NF-kappaBp65 (Ser536) has been significantly reduced in the presence of rutin.	Rutin	27-32	synaptotagmin 1	Rattus norvegicus	228-231
28467992-4	2017	Furthermore, the effect of rutin on the tumor necrosis factor-alpha and interleukin-1beta in arthritic rats showed does-dependent lowering of these cytokines with maximum benefit at 15 mg/kg dose and the level of both NF-kappaB p65 and NF-kappaBp65 (Ser536) has been significantly reduced in the presence of rutin.	Rutin	308-313	tumor necrosis factor	Rattus norvegicus	40-67
28467992-4	2017	Furthermore, the effect of rutin on the tumor necrosis factor-alpha and interleukin-1beta in arthritic rats showed does-dependent lowering of these cytokines with maximum benefit at 15 mg/kg dose and the level of both NF-kappaB p65 and NF-kappaBp65 (Ser536) has been significantly reduced in the presence of rutin.	Rutin	308-313	interleukin 1 beta	Rattus norvegicus	72-89
27923406-8	2016	A decrease in the value of C reactive protein (CRP) and a restoration in the proportion of estrous phase smears were observed in the rutin treated groups.	Rutin	133-138	C-reactive protein	Rattus norvegicus	27-45
27923406-8	2016	A decrease in the value of C reactive protein (CRP) and a restoration in the proportion of estrous phase smears were observed in the rutin treated groups.	Rutin	133-138	C-reactive protein	Rattus norvegicus	47-50
27749250-5	2016	Treatment by rutin significantly inhibited protein expressions of cytochrome P450-dependent CYP3A4 (75.3 %, p &lt; 0.0001), elevated CYP1A1 enzymes (1.7-fold, p = 0.0084) and increased protein expressions of antioxidant and phase II reaction catalyzing enzymes, NQO1 (2.42-fold, p &lt; 0.0001) and GSTP1 (2.03-fold, p &lt; 0.0001).	Rutin	13-18	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	92-98
27749250-5	2016	Treatment by rutin significantly inhibited protein expressions of cytochrome P450-dependent CYP3A4 (75.3 %, p &lt; 0.0001), elevated CYP1A1 enzymes (1.7-fold, p = 0.0084) and increased protein expressions of antioxidant and phase II reaction catalyzing enzymes, NQO1 (2.42-fold, p &lt; 0.0001) and GSTP1 (2.03-fold, p &lt; 0.0001).	Rutin	13-18	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	133-139
27749250-5	2016	Treatment by rutin significantly inhibited protein expressions of cytochrome P450-dependent CYP3A4 (75.3 %, p &lt; 0.0001), elevated CYP1A1 enzymes (1.7-fold, p = 0.0084) and increased protein expressions of antioxidant and phase II reaction catalyzing enzymes, NQO1 (2.42-fold, p &lt; 0.0001) and GSTP1 (2.03-fold, p &lt; 0.0001).	Rutin	13-18	NAD(P)H quinone dehydrogenase 1	Homo sapiens	262-266
27749250-5	2016	Treatment by rutin significantly inhibited protein expressions of cytochrome P450-dependent CYP3A4 (75.3 %, p &lt; 0.0001), elevated CYP1A1 enzymes (1.7-fold, p = 0.0084) and increased protein expressions of antioxidant and phase II reaction catalyzing enzymes, NQO1 (2.42-fold, p &lt; 0.0001) and GSTP1 (2.03-fold, p &lt; 0.0001).	Rutin	13-18	glutathione S-transferase pi 1	Homo sapiens	298-303
27749250-6	2016	Besides, rutin treatment significantly inhibited mRNA expression of CYP3A4 (73.2 %, p=0.0014).	Rutin	9-14	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	68-74
27995166-1	2017	Here we provide data describing the time-course of blood-glucose and fluid-intake profiles of diabetic hemizygous human-amylin (hA) transgenic mice orally treated with rutin, and matched control mice treated with water.	Rutin	168-173	islet amyloid polypeptide	Homo sapiens	120-126
27765347-0	2016	Neurohormetic responses of quercetin and rutin in a cell line over-expressing the amyloid precursor protein (APPswe cells).	Rutin	41-46	amyloid beta precursor protein	Homo sapiens	82-107
27765347-3	2016	PURPOSE: We attempt to explore the molecular mechanisms involved in the neurohormetic responses to quercetin and rutin exposure, in a SH-SY5Y cell line which stably overexpresses the amyloid precursor protein (APP) Swedish mutation, based on a biphasic concentration-response relationship for cell viability.	Rutin	113-118	amyloid beta precursor protein	Homo sapiens	183-208
27765347-6	2016	Activity of caspase-3 was significantly attenuated by treatment with quercetin or rutin.	Rutin	82-87	caspase 3	Homo sapiens	12-21
27765347-10	2016	CONCLUSIONS: The upregulation of the proteasome activity observed upon quercetin or rutin treatment could be afforded by a mild increased of PARP-1.	Rutin	84-89	poly(ADP-ribose) polymerase 1	Homo sapiens	141-147
27788249-3	2016	Antihemolytic experiments were conducted on quercetin, (+)catechin and rutin with excess of Fe, Cu and Zn (400 muM), and the oxidant (malondialdehyde, carbonyl proteins) and antioxidant (reduced glutathione, catalase activity) markers were evaluated.	Rutin	71-76	latexin	Homo sapiens	111-114
26919268-9	2016	Quercetin-3-rutinoside, a flavonol highly abundant in common foods, inhibits PDI and blocks thrombus formation both in vitro and in vivo.	Rutin	0-22	prolyl 4-hydroxylase subunit beta	Homo sapiens	77-80
27766950-8	2016	Molecular docking analyses were performed to check the potential of two natural inhibitors, rutin and curcumin to bind CCND1.	Rutin	92-97	cyclin D1	Homo sapiens	119-124
27766950-13	2016	The ligands - rutin and curcumin bounded with CCND1 with good affinity.	Rutin	14-19	cyclin D1	Homo sapiens	46-51
27496247-6	2016	In this study, we investigated the possible effects of flavonoids (quercetin, kaempferol, apigenin, rutin and baicalein) on stimulation of CCK release in vitro using enteroendocrine STC-1 cells.	Rutin	100-105	cholecystokinin	Homo sapiens	139-142
27496247-9	2016	To our knowledge, this is the first report to study the stimulation of CCK peptide hormone secretion from STC-1 cells by quercetin and kaempferol, rutin, apigenin and baicalein.	Rutin	147-152	cholecystokinin	Homo sapiens	71-74
27467966-5	2016	SW treatment had much enhanced rutin-combined capacity of SPI than that of conventional method, ascribing to the well-contacted for higher water solubility of rutin with stronger collision-induced hydrophobic interactions.	Rutin	31-36	chromogranin A	Homo sapiens	58-61
27467966-5	2016	SW treatment had much enhanced rutin-combined capacity of SPI than that of conventional method, ascribing to the well-contacted for higher water solubility of rutin with stronger collision-induced hydrophobic interactions.	Rutin	159-164	chromogranin A	Homo sapiens	58-61
27443845-0	2016	Cardioprotective effects of rutin via alteration in TNF-alpha, CRP, and BNP levels coupled with antioxidant effect in STZ-induced diabetic rats.	Rutin	28-33	tumor necrosis factor	Rattus norvegicus	52-61
27443845-0	2016	Cardioprotective effects of rutin via alteration in TNF-alpha, CRP, and BNP levels coupled with antioxidant effect in STZ-induced diabetic rats.	Rutin	28-33	C-reactive protein	Rattus norvegicus	63-66
27443845-0	2016	Cardioprotective effects of rutin via alteration in TNF-alpha, CRP, and BNP levels coupled with antioxidant effect in STZ-induced diabetic rats.	Rutin	28-33	natriuretic peptide B	Rattus norvegicus	72-75
27443845-6	2016	Interestingly, rutin treatment significantly ameliorated these changes with decrease in blood glucose level (p &gt; 0.001), % HbA1c (p &gt; 0.001) and reduced expression of TNF-alpha (p &lt; 0.001), CRP (p &lt; 0.001), and BNP (p &lt; 0.01) compared to diabetic control rats.	Rutin	15-20	tumor necrosis factor	Rattus norvegicus	173-182
27443845-6	2016	Interestingly, rutin treatment significantly ameliorated these changes with decrease in blood glucose level (p &gt; 0.001), % HbA1c (p &gt; 0.001) and reduced expression of TNF-alpha (p &lt; 0.001), CRP (p &lt; 0.001), and BNP (p &lt; 0.01) compared to diabetic control rats.	Rutin	15-20	C-reactive protein	Rattus norvegicus	199-202
27443845-6	2016	Interestingly, rutin treatment significantly ameliorated these changes with decrease in blood glucose level (p &gt; 0.001), % HbA1c (p &gt; 0.001) and reduced expression of TNF-alpha (p &lt; 0.001), CRP (p &lt; 0.001), and BNP (p &lt; 0.01) compared to diabetic control rats.	Rutin	15-20	natriuretic peptide B	Rattus norvegicus	223-226
27323763-0	2016	Epigallocatechin Gallate (EGCG) Decorating Soybean Seed Ferritin as a Rutin Nanocarrier with Prolonged Release Property in the Gastrointestinal Tract.	Rutin	70-75	ferritin-1, chloroplastic	Glycine max	56-64
27323763-3	2016	Firstly, due to the reversible assembly characteristics of phytoferritin, rutin was successfully encapsulated within apoSSF to form a ferritin-rutin complex (FR) with an average molar ratio of 28.2: 1 (rutin/ferritin).	Rutin	74-79	ferritin-1, chloroplastic	Glycine max	64-72
27323763-3	2016	Firstly, due to the reversible assembly characteristics of phytoferritin, rutin was successfully encapsulated within apoSSF to form a ferritin-rutin complex (FR) with an average molar ratio of 28.2: 1 (rutin/ferritin).	Rutin	74-79	ferritin-1, chloroplastic	Glycine max	134-142
27323763-3	2016	Firstly, due to the reversible assembly characteristics of phytoferritin, rutin was successfully encapsulated within apoSSF to form a ferritin-rutin complex (FR) with an average molar ratio of 28.2: 1 (rutin/ferritin).	Rutin	143-148	ferritin-1, chloroplastic	Glycine max	134-142
27552253-6	2016	Human renal glomerular endothelial cells were exposed to rutin and/or hyperglycemia for 24 h. Hyperglycemia increased permeability and decreased the junction protein occludin in the cell-cell junction area and the total expression in human renal glomerular endothelial cells, whereas rutin treatment significantly corrected these abnormalities.	Rutin	57-62	occludin	Homo sapiens	166-174
27552253-7	2016	Furthermore, hyperglycemia-induced activation of RhoA/ROCK was reversed by treatment with rutin or the knockdown of ROCK2.	Rutin	90-95	ras homolog family member A	Homo sapiens	49-53
27552253-8	2016	Interestingly, rutin prevented hyperglycemia-induced hyperpermeability, and dysfunction of the tight junction, a high level of reactive oxygen species, and activation of RhoA/ROCK were significantly abolished with the knockdown of Nrf2.	Rutin	15-20	ras homolog family member A	Homo sapiens	170-174
27552253-8	2016	Interestingly, rutin prevented hyperglycemia-induced hyperpermeability, and dysfunction of the tight junction, a high level of reactive oxygen species, and activation of RhoA/ROCK were significantly abolished with the knockdown of Nrf2.	Rutin	15-20	NFE2 like bZIP transcription factor 2	Homo sapiens	231-235
27552253-9	2016	In conclusion, rutin significantly prevented hyperglycemia-disrupted renal endothelial barrier function by inhibiting the RhoA/ROCK signaling pathway through decreasing reactive oxygen species, which was mediated by the activation of Nrf2.	Rutin	15-20	ras homolog family member A	Homo sapiens	122-126
27552253-9	2016	In conclusion, rutin significantly prevented hyperglycemia-disrupted renal endothelial barrier function by inhibiting the RhoA/ROCK signaling pathway through decreasing reactive oxygen species, which was mediated by the activation of Nrf2.	Rutin	15-20	NFE2 like bZIP transcription factor 2	Homo sapiens	234-238
26934120-12	2016	Then, five compounds including rutin, isoquercitrin, salvianolic acid A, naproxen, and felodipline were identified to be PRMT1 inhibitors.	Rutin	31-36	protein arginine methyltransferase 1	Homo sapiens	121-126
27216424-7	2016	It has been found that quercetin and rutin were the highly desirable flavonoids for the inhibition of P-gp transport function and they significantly reduced resistance in cytotoxicity assays to paclitaxel in P-gp overexpressing MDR cell lines.	Rutin	37-42	ATP binding cassette subfamily B member 1	Homo sapiens	102-106
27216424-7	2016	It has been found that quercetin and rutin were the highly desirable flavonoids for the inhibition of P-gp transport function and they significantly reduced resistance in cytotoxicity assays to paclitaxel in P-gp overexpressing MDR cell lines.	Rutin	37-42	ATP binding cassette subfamily B member 1	Homo sapiens	208-212
27035719-10	2016	These effects of rutin were in parallel with the reductions in Smad3 activity and pivotal to the fibrogenic potential of TGF-beta1.	Rutin	17-22	SMAD family member 3	Rattus norvegicus	63-68
27035719-10	2016	These effects of rutin were in parallel with the reductions in Smad3 activity and pivotal to the fibrogenic potential of TGF-beta1.	Rutin	17-22	transforming growth factor, beta 1	Rattus norvegicus	121-130
26869040-0	2016	Rutin Inhibits Neuroinflammation and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage, Possibly Through Suppressing the RAGE-NF-kappaB Inflammatory Signaling Pathway.	Rutin	0-5	MOK protein kinase	Rattus norvegicus	152-156
26869040-11	2016	This study indicated that rutin administration had a neuroprotective effect in an experimental rat model of SAH, possibly through inhibiting RAGE-NF-kappaB mediated inflammation signaling pathway.	Rutin	26-31	MOK protein kinase	Rattus norvegicus	141-145
27086847-5	2016	The present study investigated the protective effects of rutin, an activator of silent information regulator 1 (SIRT1), involved in the inhibition of NF-kappaB/MAPK signaling pathway in hydrogen peroxide (H2O2)-induced oxidative stress in rat chondrocytes.	Rutin	57-62	sirtuin 1	Rattus norvegicus	80-110
27086847-5	2016	The present study investigated the protective effects of rutin, an activator of silent information regulator 1 (SIRT1), involved in the inhibition of NF-kappaB/MAPK signaling pathway in hydrogen peroxide (H2O2)-induced oxidative stress in rat chondrocytes.	Rutin	57-62	sirtuin 1	Rattus norvegicus	112-117
27086847-6	2016	SIRT1 activation by rutin attenuated levels of inflammatory cytokines and NF-kappaB/MAPK signaling, whereas the inhibition of SIRT1 by sirtinol counteracted the beneficial effects of rutin in H2O2-treated chondrocytes.	Rutin	20-25	sirtuin 1	Rattus norvegicus	0-5
27086847-6	2016	SIRT1 activation by rutin attenuated levels of inflammatory cytokines and NF-kappaB/MAPK signaling, whereas the inhibition of SIRT1 by sirtinol counteracted the beneficial effects of rutin in H2O2-treated chondrocytes.	Rutin	183-188	sirtuin 1	Rattus norvegicus	0-5
27086847-6	2016	SIRT1 activation by rutin attenuated levels of inflammatory cytokines and NF-kappaB/MAPK signaling, whereas the inhibition of SIRT1 by sirtinol counteracted the beneficial effects of rutin in H2O2-treated chondrocytes.	Rutin	183-188	sirtuin 1	Rattus norvegicus	126-131
26576853-9	2016	Moreover, rutin also inhibited the up-regulation of caspase-3 and Bax expression and rescued down-regulation of Bcl-2 expression.	Rutin	10-15	caspase 3	Homo sapiens	52-61
26576853-9	2016	Moreover, rutin also inhibited the up-regulation of caspase-3 and Bax expression and rescued down-regulation of Bcl-2 expression.	Rutin	10-15	BCL2 associated X, apoptosis regulator	Homo sapiens	66-69
26576853-9	2016	Moreover, rutin also inhibited the up-regulation of caspase-3 and Bax expression and rescued down-regulation of Bcl-2 expression.	Rutin	10-15	BCL2 apoptosis regulator	Homo sapiens	112-117
27136576-7	2016	The expression of osteopontin, sclerostin, TNFalpha and IL6, known stimuli for decreasing osteoblast activity, were reduced with the addition of rutin or hyperoside.	Rutin	145-150	secreted phosphoprotein 1	Homo sapiens	18-29
27136576-7	2016	The expression of osteopontin, sclerostin, TNFalpha and IL6, known stimuli for decreasing osteoblast activity, were reduced with the addition of rutin or hyperoside.	Rutin	145-150	sclerostin	Homo sapiens	31-41
27136576-7	2016	The expression of osteopontin, sclerostin, TNFalpha and IL6, known stimuli for decreasing osteoblast activity, were reduced with the addition of rutin or hyperoside.	Rutin	145-150	tumor necrosis factor	Homo sapiens	43-51
27136576-7	2016	The expression of osteopontin, sclerostin, TNFalpha and IL6, known stimuli for decreasing osteoblast activity, were reduced with the addition of rutin or hyperoside.	Rutin	145-150	interleukin 6	Homo sapiens	56-59
26920631-12	2016	SIGNIFICANCE: The anti-hypertensive effect of rutin may be a useful herbal medicine for the management of hypertension due to its potential free radical scavenging, inhibition of lipid peroxidation and plasma renin inhibitory action.	Rutin	46-51	renin	Rattus norvegicus	209-214
26428697-9	2016	These results functionally characterized rutin-loaded nanoparticles as a safe SPF enhancer in sunscreens, especially in association with UV filters.	Rutin	41-46	SEC14 like lipid binding 2	Homo sapiens	78-81
25080890-9	2016	In conclusion, rutin is a potential protective agent for ALI via inhibition of neutrophil infiltration, expression of VCAM-1 and iNOS, and NFkappaB activation.	Rutin	15-20	vascular cell adhesion molecule 1	Homo sapiens	118-124
25080890-9	2016	In conclusion, rutin is a potential protective agent for ALI via inhibition of neutrophil infiltration, expression of VCAM-1 and iNOS, and NFkappaB activation.	Rutin	15-20	nitric oxide synthase 2	Homo sapiens	129-133
25080890-9	2016	In conclusion, rutin is a potential protective agent for ALI via inhibition of neutrophil infiltration, expression of VCAM-1 and iNOS, and NFkappaB activation.	Rutin	15-20	nuclear factor kappa B subunit 1	Homo sapiens	139-147
26688570-0	2016	Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats.	Rutin	0-5	NFE2 like bZIP transcription factor 2	Rattus norvegicus	101-105
26688570-11	2016	In contrast, the beneficial effect of insulin and BG-12 was inferior to that of rutin (50mg/kg), suggesting that both lowered plasma glucose and Nrf2 signaling contribute to the beneficial effect of rutin on diabetic neuropathy.	Rutin	199-204	NFE2 like bZIP transcription factor 2	Rattus norvegicus	145-149
27847821-9	2016	Following that, we found rutin and chlorogenic acid (10-100 muM) could significantly increase cell viability and decrease the production of IL-6 in UVB models.	Rutin	25-30	interleukin 6	Mus musculus	140-144
26911319-0	2016	Multi-conformer molecules in solutions: an NMR-based DFT/MP2 conformational study of two glucopyranosides of a vitamin E model compound.	Rutin	89-105	tryptase pseudogene 1	Homo sapiens	57-60
26542606-4	2016	The results showed that both rutin and isoquercitrin significantly increased antioxidant enzymes, catalase, superoxide dismutase, glutathione peroxidase, and glutathione level that were attenuated by 6-OHDA in PC-12 cells.	Rutin	29-34	catalase	Rattus norvegicus	98-106
26583522-0	2016	The increased binding affinity of curcumin with human serum albumin in the presence of rutin and baicalin: A potential for drug delivery system.	Rutin	87-92	albumin	Homo sapiens	54-67
26583522-3	2016	The binding constants between CU and HSA in the absence and presence of rutin and baicalin were 2.268x10(5)M(-1), 3.062x10(5)M(-1), and 3.271x10(5)M(-1), indicating that the binding affinity was increased in the case of two flavonoids.	Rutin	72-77	albumin	Homo sapiens	37-40
26804783-10	2016	Furthermore, rutin treatment markedly inhibited aging-related mitochondrial dysfunction, ER stress, and oxidative stress, as evidenced by increased oxygen consumption rate and activities of Na(+)/K(+)-ATPase and Ca2(+)-ATPase, decreased expression of ATF3 and GRP78, decreased level of MDA, increased content of GSH and enhanced activity of SOD in aged rats.	Rutin	13-18	activating transcription factor 3	Rattus norvegicus	251-255
26804783-10	2016	Furthermore, rutin treatment markedly inhibited aging-related mitochondrial dysfunction, ER stress, and oxidative stress, as evidenced by increased oxygen consumption rate and activities of Na(+)/K(+)-ATPase and Ca2(+)-ATPase, decreased expression of ATF3 and GRP78, decreased level of MDA, increased content of GSH and enhanced activity of SOD in aged rats.	Rutin	13-18	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	260-265
26751786-9	2016	We concluded that the rutin-priming defense signal was modulated by the salicylic acid (SA)-dependent pathway from an early stage upstream of NDR1 and EDS1.	Rutin	22-27	Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family	Arabidopsis thaliana	142-146
26751786-9	2016	We concluded that the rutin-priming defense signal was modulated by the salicylic acid (SA)-dependent pathway from an early stage upstream of NDR1 and EDS1.	Rutin	22-27	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	151-155
26585763-3	2016	Quercetin-glycosides were recently shown to prevent thrombosis in animal models through the inhibition of extracellular protein disulfide isomerase (PDI).	Rutin	0-20	prolyl 4-hydroxylase subunit beta	Homo sapiens	120-147
27644033-7	2016	Furthermore, pretreatment levels of MDA were restored, while Bcl-2-associated X protein translocation to mitochondria and cytochrome c release into cytosol were reduced by rutin treatment.	Rutin	172-177	B cell leukemia/lymphoma 2	Mus musculus	61-66
27239252-13	2016	TGF-beta/Smad signaling pathway is involved in HCD-induced hepatotoxicity and Rutin inhibits the hepatotoxicity via suppressing this pathway.	Rutin	78-83	transforming growth factor, beta 1	Rattus norvegicus	0-8
27239252-13	2016	TGF-beta/Smad signaling pathway is involved in HCD-induced hepatotoxicity and Rutin inhibits the hepatotoxicity via suppressing this pathway.	Rutin	78-83	SMAD family member 4	Rattus norvegicus	9-13
26585763-3	2016	Quercetin-glycosides were recently shown to prevent thrombosis in animal models through the inhibition of extracellular protein disulfide isomerase (PDI).	Rutin	0-20	prolyl 4-hydroxylase subunit beta	Homo sapiens	149-152
30645899-0	2016	[Effect of rutin and hesperidin on the expression of Nrf2 gene and the activity of hemoxygenase-1 and NAD(P)H-quinone oxidoreductase at their separate and combined action].	Rutin	11-16	NFE2 like bZIP transcription factor 2	Rattus norvegicus	53-57
26647798-6	2015	RESULTS: Mtx+Rutin group showed lower histological injury compared to Mtx group, MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group compared with Control-saline group.	Rutin	13-18	glutathione peroxidase 1	Rattus norvegicus	130-136
26502930-0	2015	Effect of rutin on spinal cord injury through inhibition of the expression of MIP-2 and activation of MMP-9,  and downregulation of Akt phosphorylation.	Rutin	10-15	C-X-C motif chemokine ligand 2	Rattus norvegicus	78-83
29381299-0	2016	[The effect of rutin and hesperidin on the expression of Nrf2- and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachloride].	Rutin	15-20	NFE2 like bZIP transcription factor 2	Rattus norvegicus	57-61
29381299-0	2016	[The effect of rutin and hesperidin on the expression of Nrf2- and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachloride].	Rutin	15-20	aryl hydrocarbon receptor	Rattus norvegicus	67-70
29381299-1	2016	The purpose of the study was to determine the effects of rutin (R) and hesperidin (Hes), the main representatives of two most studied subclasses of flavonoids - flavonols and flavanones, on the expression of prototypical Nrf2 and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachloride (CCl4).	Rutin	57-62	NFE2 like bZIP transcription factor 2	Rattus norvegicus	221-225
29381299-1	2016	The purpose of the study was to determine the effects of rutin (R) and hesperidin (Hes), the main representatives of two most studied subclasses of flavonoids - flavonols and flavanones, on the expression of prototypical Nrf2 and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachloride (CCl4).	Rutin	57-62	aryl hydrocarbon receptor	Rattus norvegicus	230-233
29381299-1	2016	The purpose of the study was to determine the effects of rutin (R) and hesperidin (Hes), the main representatives of two most studied subclasses of flavonoids - flavonols and flavanones, on the expression of prototypical Nrf2 and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachloride (CCl4).	Rutin	57-62	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	254-260
29381299-1	2016	The purpose of the study was to determine the effects of rutin (R) and hesperidin (Hes), the main representatives of two most studied subclasses of flavonoids - flavonols and flavanones, on the expression of prototypical Nrf2 and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachloride (CCl4).	Rutin	57-62	C-C motif chemokine ligand 4	Rattus norvegicus	313-317
26502930-11	2015	In conclusion, rutin was demonstrated as a potential protective agent in SCI and enhances the neurotrophic effect by inhibiting the expression of MIP-2 and activation of MMP-9, and downregulating the expression of p-Akt.	Rutin	15-20	AKT serine/threonine kinase 1	Rattus norvegicus	216-219
26242245-0	2015	Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress.	Rutin	0-5	islet amyloid polypeptide	Homo sapiens	15-21
26242245-5	2015	To explore the potential effects of rutin on AD, we here investigated the effect of rutin on amylin aggregation by thioflavin T dyeing, evaluated the effect of rutin on amylin-induced neurocytotoxicity by the MTT assay, and assessed oxidative stress, as well as the generation of nitric oxide (NO) and pro-inflammatory cytokines in neuronal cells.	Rutin	36-41	islet amyloid polypeptide	Homo sapiens	169-175
26242245-5	2015	To explore the potential effects of rutin on AD, we here investigated the effect of rutin on amylin aggregation by thioflavin T dyeing, evaluated the effect of rutin on amylin-induced neurocytotoxicity by the MTT assay, and assessed oxidative stress, as well as the generation of nitric oxide (NO) and pro-inflammatory cytokines in neuronal cells.	Rutin	84-89	islet amyloid polypeptide	Homo sapiens	93-99
26242245-5	2015	To explore the potential effects of rutin on AD, we here investigated the effect of rutin on amylin aggregation by thioflavin T dyeing, evaluated the effect of rutin on amylin-induced neurocytotoxicity by the MTT assay, and assessed oxidative stress, as well as the generation of nitric oxide (NO) and pro-inflammatory cytokines in neuronal cells.	Rutin	84-89	islet amyloid polypeptide	Homo sapiens	93-99
26502930-0	2015	Effect of rutin on spinal cord injury through inhibition of the expression of MIP-2 and activation of MMP-9,  and downregulation of Akt phosphorylation.	Rutin	10-15	matrix metallopeptidase 9	Rattus norvegicus	102-107
26502930-0	2015	Effect of rutin on spinal cord injury through inhibition of the expression of MIP-2 and activation of MMP-9,  and downregulation of Akt phosphorylation.	Rutin	10-15	AKT serine/threonine kinase 1	Rattus norvegicus	132-135
26502930-10	2015	The SCI rats of in the rutin-treated group were found to exhibit lower expression levels of MIP-2 and p-Akt, reduced MMP-9 activation, compared with the SCI model rats.	Rutin	23-28	C-X-C motif chemokine ligand 2	Rattus norvegicus	92-97
26502930-10	2015	The SCI rats of in the rutin-treated group were found to exhibit lower expression levels of MIP-2 and p-Akt, reduced MMP-9 activation, compared with the SCI model rats.	Rutin	23-28	AKT serine/threonine kinase 1	Rattus norvegicus	104-107
26502930-10	2015	The SCI rats of in the rutin-treated group were found to exhibit lower expression levels of MIP-2 and p-Akt, reduced MMP-9 activation, compared with the SCI model rats.	Rutin	23-28	matrix metallopeptidase 9	Rattus norvegicus	117-122
26502930-11	2015	In conclusion, rutin was demonstrated as a potential protective agent in SCI and enhances the neurotrophic effect by inhibiting the expression of MIP-2 and activation of MMP-9, and downregulating the expression of p-Akt.	Rutin	15-20	C-X-C motif chemokine ligand 2	Rattus norvegicus	146-151
26502930-11	2015	In conclusion, rutin was demonstrated as a potential protective agent in SCI and enhances the neurotrophic effect by inhibiting the expression of MIP-2 and activation of MMP-9, and downregulating the expression of p-Akt.	Rutin	15-20	matrix metallopeptidase 9	Rattus norvegicus	170-175
26240139-1	2015	Quercetin-3-rutinoside inhibits thrombus formation in a mouse model by inhibiting extracellular protein disulfide isomerase (PDI), an enzyme required for platelet thrombus formation and fibrin generation.	Rutin	0-22	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	96-123
26240139-1	2015	Quercetin-3-rutinoside inhibits thrombus formation in a mouse model by inhibiting extracellular protein disulfide isomerase (PDI), an enzyme required for platelet thrombus formation and fibrin generation.	Rutin	0-22	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	125-128
26240139-3	2015	Using a fluorescence enhancement-based assay and isothermal calorimetry, we show that quercetin-3-rutinoside directly binds to the b" domain of PDI with a 1:1 stoichiometry.	Rutin	86-108	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	144-147
26240139-4	2015	The binding of quercetin-3-rutinoside to PDI induces a more compact conformation and restricts the conformational flexibility of PDI, as revealed by small angle x-ray scattering.	Rutin	15-37	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	41-44
26240139-4	2015	The binding of quercetin-3-rutinoside to PDI induces a more compact conformation and restricts the conformational flexibility of PDI, as revealed by small angle x-ray scattering.	Rutin	15-37	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	129-132
26240139-5	2015	The binding sites of quercetin-3-rutinoside to PDI were determined by studying its interaction with isolated fragments of PDI.	Rutin	21-43	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	47-50
26240139-5	2015	The binding sites of quercetin-3-rutinoside to PDI were determined by studying its interaction with isolated fragments of PDI.	Rutin	21-43	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	122-125
26240139-9	2015	The isolated b" domain of PDI has potential as an antidote to reverse the antithrombotic effect of quercetin-3-rutinoside by binding and neutralizing quercetin-3-rutinoside.	Rutin	99-121	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	26-29
26240139-9	2015	The isolated b" domain of PDI has potential as an antidote to reverse the antithrombotic effect of quercetin-3-rutinoside by binding and neutralizing quercetin-3-rutinoside.	Rutin	150-172	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	26-29
26388478-6	2015	The proposed modified electrode has a linear response range of 0.01-10.00 muM both for myricetin and rutin with relatively low detection limits of 0.0038 muM for myricetin and 0.0044 muM (S/N = 3) for rutin, respectively.	Rutin	101-106	latexin	Homo sapiens	74-77
26388478-6	2015	The proposed modified electrode has a linear response range of 0.01-10.00 muM both for myricetin and rutin with relatively low detection limits of 0.0038 muM for myricetin and 0.0044 muM (S/N = 3) for rutin, respectively.	Rutin	101-106	latexin	Homo sapiens	154-157
26388478-6	2015	The proposed modified electrode has a linear response range of 0.01-10.00 muM both for myricetin and rutin with relatively low detection limits of 0.0038 muM for myricetin and 0.0044 muM (S/N = 3) for rutin, respectively.	Rutin	101-106	latexin	Homo sapiens	154-157
26255195-0	2015	Rutin, A Natural Flavonoid Protects PC12 Cells Against Sodium Nitroprusside-Induced Neurotoxicity Through Activating PI3K/Akt/mTOR and ERK1/2 Pathway.	Rutin	0-5	AKT serine/threonine kinase 1	Rattus norvegicus	122-125
26255195-0	2015	Rutin, A Natural Flavonoid Protects PC12 Cells Against Sodium Nitroprusside-Induced Neurotoxicity Through Activating PI3K/Akt/mTOR and ERK1/2 Pathway.	Rutin	0-5	mechanistic target of rapamycin kinase	Rattus norvegicus	126-130
26255195-0	2015	Rutin, A Natural Flavonoid Protects PC12 Cells Against Sodium Nitroprusside-Induced Neurotoxicity Through Activating PI3K/Akt/mTOR and ERK1/2 Pathway.	Rutin	0-5	mitogen activated protein kinase 3	Rattus norvegicus	135-141
26255195-6	2015	Moreover, rutin activated both the protein Akt/mTOR and the extracellular signal-regulated kinase (ERK1/2) signaling pathways and the neuroprotective effects of rutin were blocked by either the specific PI3K inhibitor LY294002 or the MAPK pathway inhibitor PD98059.	Rutin	10-15	AKT serine/threonine kinase 1	Rattus norvegicus	43-46
26255195-6	2015	Moreover, rutin activated both the protein Akt/mTOR and the extracellular signal-regulated kinase (ERK1/2) signaling pathways and the neuroprotective effects of rutin were blocked by either the specific PI3K inhibitor LY294002 or the MAPK pathway inhibitor PD98059.	Rutin	10-15	mechanistic target of rapamycin kinase	Rattus norvegicus	47-51
26255195-6	2015	Moreover, rutin activated both the protein Akt/mTOR and the extracellular signal-regulated kinase (ERK1/2) signaling pathways and the neuroprotective effects of rutin were blocked by either the specific PI3K inhibitor LY294002 or the MAPK pathway inhibitor PD98059.	Rutin	10-15	mitogen activated protein kinase 3	Rattus norvegicus	99-105
26255195-6	2015	Moreover, rutin activated both the protein Akt/mTOR and the extracellular signal-regulated kinase (ERK1/2) signaling pathways and the neuroprotective effects of rutin were blocked by either the specific PI3K inhibitor LY294002 or the MAPK pathway inhibitor PD98059.	Rutin	10-15	mitogen activated protein kinase 3	Rattus norvegicus	234-238
26255195-6	2015	Moreover, rutin activated both the protein Akt/mTOR and the extracellular signal-regulated kinase (ERK1/2) signaling pathways and the neuroprotective effects of rutin were blocked by either the specific PI3K inhibitor LY294002 or the MAPK pathway inhibitor PD98059.	Rutin	161-166	mitogen activated protein kinase 3	Rattus norvegicus	99-105
26255195-6	2015	Moreover, rutin activated both the protein Akt/mTOR and the extracellular signal-regulated kinase (ERK1/2) signaling pathways and the neuroprotective effects of rutin were blocked by either the specific PI3K inhibitor LY294002 or the MAPK pathway inhibitor PD98059.	Rutin	161-166	mitogen activated protein kinase 3	Rattus norvegicus	234-238
26255195-7	2015	In summary, these results demonstrated that the neuroprotective effects of rutin might be through activating both the PI3K/Akt/mTOR and ERK1/2 signaling pathways.	Rutin	75-80	AKT serine/threonine kinase 1	Rattus norvegicus	123-126
26255195-7	2015	In summary, these results demonstrated that the neuroprotective effects of rutin might be through activating both the PI3K/Akt/mTOR and ERK1/2 signaling pathways.	Rutin	75-80	mechanistic target of rapamycin kinase	Rattus norvegicus	127-131
26255195-7	2015	In summary, these results demonstrated that the neuroprotective effects of rutin might be through activating both the PI3K/Akt/mTOR and ERK1/2 signaling pathways.	Rutin	75-80	mitogen activated protein kinase 3	Rattus norvegicus	136-142
25251136-6	2015	RESULTS: We found that rutin pretreatment prevented the ethanol-induced decrease in protein level expression of nerve growth factor, glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) in HT22 cells.	Rutin	23-28	nerve growth factor	Mus musculus	112-131
26242245-6	2015	Our results showed that the flavonoid antioxidant rutin inhibited amylin-induced neurocytotoxicity, decreased the production of reactive oxygen species (ROS), NO, glutathione disulfide (GSSG), malondialdehyde (MDA) and pro-inflammatory cytokines TNF-alpha and IL-1beta, attenuated mitochondrial damage and increased the GSH/GSSG ratio.	Rutin	50-55	islet amyloid polypeptide	Homo sapiens	66-72
26242245-6	2015	Our results showed that the flavonoid antioxidant rutin inhibited amylin-induced neurocytotoxicity, decreased the production of reactive oxygen species (ROS), NO, glutathione disulfide (GSSG), malondialdehyde (MDA) and pro-inflammatory cytokines TNF-alpha and IL-1beta, attenuated mitochondrial damage and increased the GSH/GSSG ratio.	Rutin	50-55	tumor necrosis factor	Homo sapiens	246-255
26242245-6	2015	Our results showed that the flavonoid antioxidant rutin inhibited amylin-induced neurocytotoxicity, decreased the production of reactive oxygen species (ROS), NO, glutathione disulfide (GSSG), malondialdehyde (MDA) and pro-inflammatory cytokines TNF-alpha and IL-1beta, attenuated mitochondrial damage and increased the GSH/GSSG ratio.	Rutin	50-55	interleukin 1 alpha	Homo sapiens	260-268
26242245-7	2015	These protective effects of rutin may have resulted from its ability to inhibit amylin aggregation, enhance the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and reduce inducible nitric oxide synthase (iNOS) activity.	Rutin	28-33	islet amyloid polypeptide	Homo sapiens	80-86
26242245-7	2015	These protective effects of rutin may have resulted from its ability to inhibit amylin aggregation, enhance the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and reduce inducible nitric oxide synthase (iNOS) activity.	Rutin	28-33	superoxide dismutase 1	Homo sapiens	143-163
26242245-7	2015	These protective effects of rutin may have resulted from its ability to inhibit amylin aggregation, enhance the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and reduce inducible nitric oxide synthase (iNOS) activity.	Rutin	28-33	superoxide dismutase 1	Homo sapiens	165-168
26242245-7	2015	These protective effects of rutin may have resulted from its ability to inhibit amylin aggregation, enhance the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and reduce inducible nitric oxide synthase (iNOS) activity.	Rutin	28-33	catalase	Homo sapiens	171-179
26242245-7	2015	These protective effects of rutin may have resulted from its ability to inhibit amylin aggregation, enhance the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and reduce inducible nitric oxide synthase (iNOS) activity.	Rutin	28-33	catalase	Homo sapiens	181-184
26242245-7	2015	These protective effects of rutin may have resulted from its ability to inhibit amylin aggregation, enhance the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and reduce inducible nitric oxide synthase (iNOS) activity.	Rutin	28-33	nitric oxide synthase 2	Homo sapiens	231-262
26242245-7	2015	These protective effects of rutin may have resulted from its ability to inhibit amylin aggregation, enhance the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and reduce inducible nitric oxide synthase (iNOS) activity.	Rutin	28-33	nitric oxide synthase 2	Homo sapiens	264-268
26242245-8	2015	These in vitro results indicate that rutin is a promising natural product for protecting neuronal cells from amylin-induced neurotoxicity and oxidative stress, and rutin administration could be a feasible therapeutic strategy for preventing AD development and protecting the aging brain or slowing neurodegenerative processes.	Rutin	37-42	islet amyloid polypeptide	Homo sapiens	109-115
25251136-6	2015	RESULTS: We found that rutin pretreatment prevented the ethanol-induced decrease in protein level expression of nerve growth factor, glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) in HT22 cells.	Rutin	23-28	glial cell line derived neurotrophic factor	Mus musculus	133-176
25251136-6	2015	RESULTS: We found that rutin pretreatment prevented the ethanol-induced decrease in protein level expression of nerve growth factor, glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) in HT22 cells.	Rutin	23-28	glial cell line derived neurotrophic factor	Mus musculus	178-182
25251136-6	2015	RESULTS: We found that rutin pretreatment prevented the ethanol-induced decrease in protein level expression of nerve growth factor, glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) in HT22 cells.	Rutin	23-28	brain derived neurotrophic factor	Mus musculus	188-221
25251136-6	2015	RESULTS: We found that rutin pretreatment prevented the ethanol-induced decrease in protein level expression of nerve growth factor, glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) in HT22 cells.	Rutin	23-28	brain derived neurotrophic factor	Mus musculus	223-227
25777266-8	2015	In vivo study showed that rutin exerted a significant protective effect against collagen and epinephrine (or thrombin) induced acute thromboembolism in mice.	Rutin	26-31	coagulation factor II	Mus musculus	109-117
25656645-2	2015	Herein, the interaction between human serum albumin (HSA) and NDP and the influence of flavonoids, rutin and baicalin, on their binding properties were investigated in vitro by means of fluorescence and absorption spectroscopy.	Rutin	99-104	norrin cystine knot growth factor NDP	Homo sapiens	38-65
25918240-9	2015	Rutin acted as a competitive inhibitor for the reduction of daunorubicin (cbr1 D218 Ki: 1.84 +- 1.02 muM, cbr1 V218 Ki: 1.38 +- 0.47 muM).	Rutin	0-5	carbonyl reductase [NADPH] 1	Canis lupus familiaris	74-78
25918240-9	2015	Rutin acted as a competitive inhibitor for the reduction of daunorubicin (cbr1 D218 Ki: 1.84 +- 1.02 muM, cbr1 V218 Ki: 1.38 +- 0.47 muM).	Rutin	0-5	carbonyl reductase [NADPH] 1	Canis lupus familiaris	106-110
26139922-2	2015	The present study was aimed to compare the inhibitory potential of selected common dietary bioactive molecules (Gallic acid, Ellagic acid, beta-Sitosterol, Stigmasterol, Quercetin and Rutin) on CYP3A4 and CYP2D6 to assess safety through its inhibitory potency and to predict interaction potential with co-administered drugs.	Rutin	184-189	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	205-211
26062544-12	2015	Interestingly, rutin supplementation completely reversed the biochemical markers of hepatotoxicity and the gene expression alterations induced by CCl4.	Rutin	15-20	C-C motif chemokine ligand 4	Rattus norvegicus	146-150
25929832-11	2015	In addition, rutin treatment showed antiapoptotic activity by decreasing the level of caspase-3 and increasing the level of Bcl-2 in the diabetic retina.	Rutin	13-18	caspase 3	Rattus norvegicus	86-95
25929832-11	2015	In addition, rutin treatment showed antiapoptotic activity by decreasing the level of caspase-3 and increasing the level of Bcl-2 in the diabetic retina.	Rutin	13-18	BCL2, apoptosis regulator	Rattus norvegicus	124-129
26191162-11	2015	By western blot, we found the rutin could reduce the TGF-beta1, p-smad2 expression in the kidney tissues of rats.	Rutin	30-35	transforming growth factor, beta 1	Rattus norvegicus	53-62
26191162-11	2015	By western blot, we found the rutin could reduce the TGF-beta1, p-smad2 expression in the kidney tissues of rats.	Rutin	30-35	SMAD family member 2	Rattus norvegicus	66-71
25442518-3	2015	Tensile strengths of SPI films with rutin and epicatechin were similar (35.1 MPa and 22.1 MPa, respectively) and significantly stronger than films without added phenolics (9.3 MPa).	Rutin	36-41	chromogranin A	Homo sapiens	21-24
25442518-7	2015	Findings indicate that rutin and epicatechin may be used as a natural means for improving specific properties of SPI films.	Rutin	23-28	chromogranin A	Homo sapiens	113-116
25467059-0	2015	Inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA1) by rutin derivatives.	Rutin	70-75	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	59-65
25467059-1	2015	The effect of lipophilic rutin derivatives (acylated with fatty acid chain length of 16-22) on sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA1 isoform) compared to the parent molecule rutin was evaluated.	Rutin	25-30	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	138-144
25467059-2	2015	Rutin derivatives caused concentration dependent decrease of SERCA1 activity (IC50 ~ 23-64 microM) and significant conformational alterations in the transmembrane region of the enzyme.	Rutin	0-5	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	61-67
25547066-4	2015	In the absence of ONOO(-), rutin (250 and 350 microM) stimulated SERCA1 activity at 2.1 mM [ATP] and 10 microM [Ca(2+)]free.	Rutin	27-32	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	65-71
25547066-5	2015	According to changes in the kinetic parameters V max and K m with regard to [ATP], rutin (250 microM) increased the rate of enzyme catalysis and decreased the affinity of SERCA1 to ATP.	Rutin	83-88	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	171-177
25613739-6	2015	Rutin pretreatment attenuated nephrotoxicity induced by gentamicin by reducing the urea, creatinine, and MDA levels and increasing the SOD, CAT, and GPx activity, and the GSH levels.	Rutin	0-5	catalase	Rattus norvegicus	140-143
25700620-5	2015	RESULTS AND CONCLUSIONS: A variety of thiol isomerase enzymes, including PDI, were expressed by HMEC-1 cells and thiol reductase activity detectable on the cell surface was inhibited by both RL90 anti-PDI antibody and by the PDI inhibitor quercetin-3-rutinoside (rutin).	Rutin	239-261	prolyl 4-hydroxylase subunit beta	Homo sapiens	73-76
25700620-5	2015	RESULTS AND CONCLUSIONS: A variety of thiol isomerase enzymes, including PDI, were expressed by HMEC-1 cells and thiol reductase activity detectable on the cell surface was inhibited by both RL90 anti-PDI antibody and by the PDI inhibitor quercetin-3-rutinoside (rutin).	Rutin	239-261	prolyl 4-hydroxylase subunit beta	Homo sapiens	201-204
25700620-5	2015	RESULTS AND CONCLUSIONS: A variety of thiol isomerase enzymes, including PDI, were expressed by HMEC-1 cells and thiol reductase activity detectable on the cell surface was inhibited by both RL90 anti-PDI antibody and by the PDI inhibitor quercetin-3-rutinoside (rutin).	Rutin	239-261	prolyl 4-hydroxylase subunit beta	Homo sapiens	201-204
25700620-5	2015	RESULTS AND CONCLUSIONS: A variety of thiol isomerase enzymes, including PDI, were expressed by HMEC-1 cells and thiol reductase activity detectable on the cell surface was inhibited by both RL90 anti-PDI antibody and by the PDI inhibitor quercetin-3-rutinoside (rutin).	Rutin	251-256	prolyl 4-hydroxylase subunit beta	Homo sapiens	73-76
25700620-5	2015	RESULTS AND CONCLUSIONS: A variety of thiol isomerase enzymes, including PDI, were expressed by HMEC-1 cells and thiol reductase activity detectable on the cell surface was inhibited by both RL90 anti-PDI antibody and by the PDI inhibitor quercetin-3-rutinoside (rutin).	Rutin	251-256	prolyl 4-hydroxylase subunit beta	Homo sapiens	201-204
25700620-5	2015	RESULTS AND CONCLUSIONS: A variety of thiol isomerase enzymes, including PDI, were expressed by HMEC-1 cells and thiol reductase activity detectable on the cell surface was inhibited by both RL90 anti-PDI antibody and by the PDI inhibitor quercetin-3-rutinoside (rutin).	Rutin	251-256	prolyl 4-hydroxylase subunit beta	Homo sapiens	201-204
24895146-0	2015	Differential effects of quercetin glycosides on GABAC receptor channel activity.	Rutin	24-44	gamma-aminobutyric acid type A receptor subunit rho1	Homo sapiens	48-62
26387381-7	2015	Such effects of rutin on adiponectin secretion and adipocyte activity may account for, at least in part, the antidiabetic effects of consumption of food containing rutin.	Rutin	16-21	adiponectin, C1Q and collagen domain containing	Mus musculus	25-36
26387381-7	2015	Such effects of rutin on adiponectin secretion and adipocyte activity may account for, at least in part, the antidiabetic effects of consumption of food containing rutin.	Rutin	164-169	adiponectin, C1Q and collagen domain containing	Mus musculus	25-36
25129099-4	2015	Rutin-pretreated PC12 attenuated the Park2, Park5, Park7, Casp3, and Casp7 genes which were expressed significantly in the 6-OHDA-treated PC12 cells.	Rutin	0-5	parkin RBR E3 ubiquitin protein ligase	Rattus norvegicus	37-42
25129099-4	2015	Rutin-pretreated PC12 attenuated the Park2, Park5, Park7, Casp3, and Casp7 genes which were expressed significantly in the 6-OHDA-treated PC12 cells.	Rutin	0-5	Parkinsonism associated deglycase	Rattus norvegicus	51-56
25129099-4	2015	Rutin-pretreated PC12 attenuated the Park2, Park5, Park7, Casp3, and Casp7 genes which were expressed significantly in the 6-OHDA-treated PC12 cells.	Rutin	0-5	caspase 3	Rattus norvegicus	58-63
25129099-4	2015	Rutin-pretreated PC12 attenuated the Park2, Park5, Park7, Casp3, and Casp7 genes which were expressed significantly in the 6-OHDA-treated PC12 cells.	Rutin	0-5	caspase 7	Rattus norvegicus	69-74
25129099-6	2015	Both rutin and isoquercitrin pretreatments upregulated the ion transport and antiapoptotic genes (NSF and Opa1).	Rutin	5-10	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Rattus norvegicus	98-101
25129099-6	2015	Both rutin and isoquercitrin pretreatments upregulated the ion transport and antiapoptotic genes (NSF and Opa1).	Rutin	5-10	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	106-110
24895146-6	2015	In the present study, we examined the effects of quercetin glycosides on GABAC receptor channel activity by expressing human GABAC alone in Xenopus oocytes using a two-electrode voltage clamp technique and also compared the effects of quercetin glycosides with quercetin.	Rutin	49-69	gamma-aminobutyric acid type A receptor subunit rho1	Homo sapiens	73-87
26633020-3	2015	The catechol moiety of Cat, Que, and rutin plays an essential role in concerted proton-coupled electron transfer (PCET) to HO2( ) derived from O2( -) to give H2O2 and the corresponding o-benzoquinone radical anions.	Rutin	37-42	heme oxygenase 2	Homo sapiens	123-126
25104801-3	2015	The observation that the commonly ingested quercetin flavonoid, quercetin-3-rutinoside, inhibits protein disulfide isomerase and blocks thrombus formation in preclinical studies has set the stage for clinical trials using protein disulfide isomerase antagonists as antithrombotics.	Rutin	64-86	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	97-124
25104801-3	2015	The observation that the commonly ingested quercetin flavonoid, quercetin-3-rutinoside, inhibits protein disulfide isomerase and blocks thrombus formation in preclinical studies has set the stage for clinical trials using protein disulfide isomerase antagonists as antithrombotics.	Rutin	64-86	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	222-249
25613621-8	2015	CONCLUSION: Rutin pretreatment offers protective effect against TMT-induced learning and memory impairment in mice possibly by antagonizing decreased synaptophysin in the hippocampus and cortex.	Rutin	12-17	synaptophysin	Mus musculus	150-163
25369199-7	2014	In UVB-exposed normal human dermal fibroblasts cells with VAE and rutin treatments, MMP-1 production was significantly suppressed (90% and 47%, respectively).	Rutin	66-71	matrix metallopeptidase 1	Homo sapiens	84-89
25468534-10	2015	A comparison of a wide spectrum of beta-glucosides showed that recombinant BGLU15 preferentially hydrolyses the 3-O-beta-glucosides of flavonols, but does not attack quercetin 3-O-alpha-rhamnoside, quercetin 3-O-beta-galactoside and rutin.	Rutin	233-238	beta glucosidase 15	Arabidopsis thaliana	75-81
24875145-6	2014	Topical application of rutin also significantly inhibited UVB-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), two representative inflammatory enzymes, in hairless mouse skin.	Rutin	23-28	prostaglandin-endoperoxide synthase 2	Mus musculus	84-100
25060908-5	2014	In the present study, the effect of rutin, a natural flavonoid on the expression of ASC of NLRP3, was investigated in rats treated with ethanol (EtOH) and cerulein (Cer).	Rutin	36-41	PYD and CARD domain containing	Rattus norvegicus	84-87
25060908-5	2014	In the present study, the effect of rutin, a natural flavonoid on the expression of ASC of NLRP3, was investigated in rats treated with ethanol (EtOH) and cerulein (Cer).	Rutin	36-41	NLR family, pyrin domain containing 3	Rattus norvegicus	91-96
25060908-11	2014	The results of the study revealed that rutin can reduce inflammation in pancreas probably by influencing the down regulation of ASC-NLRP3 which might result in the reduced activation of caspase-1 and controlled cytokine production.	Rutin	39-44	PYD and CARD domain containing	Rattus norvegicus	128-131
25060908-11	2014	The results of the study revealed that rutin can reduce inflammation in pancreas probably by influencing the down regulation of ASC-NLRP3 which might result in the reduced activation of caspase-1 and controlled cytokine production.	Rutin	39-44	NLR family, pyrin domain containing 3	Rattus norvegicus	132-137
25060908-11	2014	The results of the study revealed that rutin can reduce inflammation in pancreas probably by influencing the down regulation of ASC-NLRP3 which might result in the reduced activation of caspase-1 and controlled cytokine production.	Rutin	39-44	caspase 1	Rattus norvegicus	186-195
25281414-8	2014	The colonic expression of proinflammatory genes, including IFNgamma, TNFalpha, CXCL1, S100A8 and IL-1beta, was significantly reduced by more than 80% with rutin as assessed by RT-qPCR.	Rutin	155-160	interferon gamma	Mus musculus	59-67
25281414-8	2014	The colonic expression of proinflammatory genes, including IFNgamma, TNFalpha, CXCL1, S100A8 and IL-1beta, was significantly reduced by more than 80% with rutin as assessed by RT-qPCR.	Rutin	155-160	tumor necrosis factor	Mus musculus	69-77
25281414-8	2014	The colonic expression of proinflammatory genes, including IFNgamma, TNFalpha, CXCL1, S100A8 and IL-1beta, was significantly reduced by more than 80% with rutin as assessed by RT-qPCR.	Rutin	155-160	chemokine (C-X-C motif) ligand 1	Mus musculus	79-84
25281414-8	2014	The colonic expression of proinflammatory genes, including IFNgamma, TNFalpha, CXCL1, S100A8 and IL-1beta, was significantly reduced by more than 80% with rutin as assessed by RT-qPCR.	Rutin	155-160	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	86-92
25281414-8	2014	The colonic expression of proinflammatory genes, including IFNgamma, TNFalpha, CXCL1, S100A8 and IL-1beta, was significantly reduced by more than 80% with rutin as assessed by RT-qPCR.	Rutin	155-160	interleukin 1 beta	Mus musculus	97-105
25262941-3	2014	Based on the structure of rutin, a typical flavonoid and one of the NMU2R agonists we previously identified from an in-house made natural product library, 30 flavonoid derivatives have been synthesized and screened on a cell-based reporter gene assay.	Rutin	26-31	neuromedin U receptor 2	Homo sapiens	68-73
24876151-7	2014	We also tested two of the BRM-inducing flavonoids (Rutin and Diosmin) at both a low and a high dose on the development of tumors in an established murine lung cancer model.	Rutin	51-56	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	26-29
24875145-6	2014	Topical application of rutin also significantly inhibited UVB-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), two representative inflammatory enzymes, in hairless mouse skin.	Rutin	23-28	prostaglandin-endoperoxide synthase 2	Mus musculus	102-107
24875145-6	2014	Topical application of rutin also significantly inhibited UVB-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), two representative inflammatory enzymes, in hairless mouse skin.	Rutin	23-28	nitric oxide synthase 2, inducible	Mus musculus	113-144
24875145-6	2014	Topical application of rutin also significantly inhibited UVB-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), two representative inflammatory enzymes, in hairless mouse skin.	Rutin	23-28	nitric oxide synthase 2, inducible	Mus musculus	146-150
24875145-8	2014	Moreover, rutin attenuated UVB-induced phosphorylation of p38 mitogen-activated protein (MAP) kinase and c-Jun-N-terminal kinase (JNK).	Rutin	10-15	mitogen-activated protein kinase 14	Mus musculus	58-61
24875145-8	2014	Moreover, rutin attenuated UVB-induced phosphorylation of p38 mitogen-activated protein (MAP) kinase and c-Jun-N-terminal kinase (JNK).	Rutin	10-15	mitogen-activated protein kinase 8	Mus musculus	105-128
24875145-8	2014	Moreover, rutin attenuated UVB-induced phosphorylation of p38 mitogen-activated protein (MAP) kinase and c-Jun-N-terminal kinase (JNK).	Rutin	10-15	mitogen-activated protein kinase 8	Mus musculus	130-133
25091621-0	2014	Protective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation.	Rutin	21-26	C-X-C motif chemokine ligand 2	Homo sapiens	83-88
25091621-0	2014	Protective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation.	Rutin	21-26	matrix metallopeptidase 9	Homo sapiens	104-109
25091621-0	2014	Protective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation.	Rutin	21-26	AKT serine/threonine kinase 1	Homo sapiens	143-146
25091621-6	2014	In addition, the inhibitory concentration of rutin on phosphorylation of Akt was similar as MIP-2 expression and MMP-9 activation.	Rutin	45-50	AKT serine/threonine kinase 1	Homo sapiens	73-76
25091621-6	2014	In addition, the inhibitory concentration of rutin on phosphorylation of Akt was similar as MIP-2 expression and MMP-9 activation.	Rutin	45-50	matrix metallopeptidase 9	Homo sapiens	113-118
24001577-0	2014	Synaptophysin and the dopaminergic system in hippocampus are involved in the protective effect of rutin against trimethyltin-induced learning and memory impairment.	Rutin	98-103	synaptophysin	Mus musculus	0-13
24731381-6	2014	Increased glucose uptake in L6 myotubes was attributed to GLUT 4 translocation, the most downstream factor in the insulin signalling cascade, which increased two to threefold on chronic pretreatment of quercetin (10 muM) and rutin (100 muM).	Rutin	225-230	solute carrier family 2 member 4	Homo sapiens	58-64
24287373-0	2014	Expression of caspase activation recruitment and pyrin domain levels of apoptosis-associated speck-like protein complex in the pancreas of rats subjected to experimental pancreatitis: influence of rutin administration.	Rutin	197-202	PYD and CARD domain containing	Rattus norvegicus	72-111
24287373-1	2014	The present study investigated the effect of rutin, a natural flavonoid, on the expression of caspase activation recruitment domain (CARD) and pyrin domain (PYD) of apoptosis-associated speck-like protein (ASC), a mediator of inflammation, in the pancreas of rats administered with ethanol (EtOH) and high-fat diet (HFD).	Rutin	45-50	PYD and CARD domain containing	Rattus norvegicus	165-204
24287373-1	2014	The present study investigated the effect of rutin, a natural flavonoid, on the expression of caspase activation recruitment domain (CARD) and pyrin domain (PYD) of apoptosis-associated speck-like protein (ASC), a mediator of inflammation, in the pancreas of rats administered with ethanol (EtOH) and high-fat diet (HFD).	Rutin	45-50	PYD and CARD domain containing	Rattus norvegicus	206-209
24287373-6	2014	Rutin administration along with EtOH and HFD significantly upregulated the mRNA expression of CARD and downregulated PYD, caspase-1, and TNF-alpha expressions.	Rutin	0-5	caspase 1	Rattus norvegicus	122-131
24287373-6	2014	Rutin administration along with EtOH and HFD significantly upregulated the mRNA expression of CARD and downregulated PYD, caspase-1, and TNF-alpha expressions.	Rutin	0-5	tumor necrosis factor	Rattus norvegicus	137-146
24287373-7	2014	Rutin supplementation was also found to reduce IL-18 and IL-6 levels; and inflammatory changes in tissue architecture were evidenced by histological observations.	Rutin	0-5	interleukin 18	Rattus norvegicus	47-52
24287373-7	2014	Rutin supplementation was also found to reduce IL-18 and IL-6 levels; and inflammatory changes in tissue architecture were evidenced by histological observations.	Rutin	0-5	interleukin 6	Rattus norvegicus	57-61
24857031-10	2014	Taken together, the present study unveils rutin and curcumin as a possible effective stimulation for fatty acid-induced autophagy via mTOR-dependent pathways in NHSC.	Rutin	42-47	mechanistic target of rapamycin kinase	Homo sapiens	134-138
24622777-6	2014	Data showed rutin was a potent inhibitor of PMA, TNF-alpha, IL-1beta, and CLP-induced EPCR shedding by suppression of TACE expression.	Rutin	12-17	tumor necrosis factor	Homo sapiens	49-58
24622777-6	2014	Data showed rutin was a potent inhibitor of PMA, TNF-alpha, IL-1beta, and CLP-induced EPCR shedding by suppression of TACE expression.	Rutin	12-17	interleukin 1 beta	Homo sapiens	60-68
24622777-6	2014	Data showed rutin was a potent inhibitor of PMA, TNF-alpha, IL-1beta, and CLP-induced EPCR shedding by suppression of TACE expression.	Rutin	12-17	protein C receptor	Homo sapiens	86-90
24622777-6	2014	Data showed rutin was a potent inhibitor of PMA, TNF-alpha, IL-1beta, and CLP-induced EPCR shedding by suppression of TACE expression.	Rutin	12-17	ADAM metallopeptidase domain 17	Homo sapiens	118-122
24622777-7	2014	Treatment with rutin resulted in a decrease of PMA-stimulated phosphorylation of p38, extracellular regulated kinases 1/2, and c-Jun N-terminal kinase.	Rutin	15-20	mitogen-activated protein kinase 14	Homo sapiens	81-84
25046753-0	2014	Higher peroxidase activity, leaf nutrient contents and carbon isotope composition changes in Arabidopsis thaliana are related to rutin stress.	Rutin	129-134	peroxidase	Arabidopsis thaliana	7-17
24001577-10	2014	Moreover, rutin pretreatment reversed the decrease of synaptophysin expression and dopamine alteration.	Rutin	10-15	synaptophysin	Mus musculus	54-67
26031015-14	2014	Rutin administration to iron-overloaded rats resulted in significant decrease in serum total iron, TIBC, Tf, TS%, ferritin levels and AST and ALT activities and liver total iron, L-MDA and NO levels with significant increases in serum UIBC, albumin, total protein and total cholesterol levels and in liver GSH, CAT and SOD activities compared with the IOL group.	Rutin	0-5	transferrin	Rattus norvegicus	105-107
24815012-9	2014	The antifibrotic effect of rutin was accompanied by reductions in alpha-smooth muscle actin-positive matrix-producing cells and Smad2/3 activity critical to the fibrogenic potential of TGF-beta1.	Rutin	27-32	SMAD family member 2	Rattus norvegicus	128-135
24815012-9	2014	The antifibrotic effect of rutin was accompanied by reductions in alpha-smooth muscle actin-positive matrix-producing cells and Smad2/3 activity critical to the fibrogenic potential of TGF-beta1.	Rutin	27-32	transforming growth factor, beta 1	Rattus norvegicus	185-194
24815012-11	2014	Further studies demonstrated an inhibitory effect of rutin on the redox-sensitive intracellular signaling molecule extracellular signal-regulated kinase (ERK).	Rutin	53-58	Eph receptor B1	Rattus norvegicus	115-152
24815012-11	2014	Further studies demonstrated an inhibitory effect of rutin on the redox-sensitive intracellular signaling molecule extracellular signal-regulated kinase (ERK).	Rutin	53-58	Eph receptor B1	Rattus norvegicus	154-157
24815012-13	2014	Taken together, the beneficial effects of rutin were shown to be associated with antioxidative and anti-inflammatory effects as well as the downregulation of NF-kappaB and TGF-beta/Smad signaling, probably via interference of ERK activation and/or enhancement of Nrf2, HO-1, and AMPK activity.	Rutin	42-47	transforming growth factor, beta 1	Rattus norvegicus	172-180
24815012-13	2014	Taken together, the beneficial effects of rutin were shown to be associated with antioxidative and anti-inflammatory effects as well as the downregulation of NF-kappaB and TGF-beta/Smad signaling, probably via interference of ERK activation and/or enhancement of Nrf2, HO-1, and AMPK activity.	Rutin	42-47	Eph receptor B1	Rattus norvegicus	226-229
24815012-13	2014	Taken together, the beneficial effects of rutin were shown to be associated with antioxidative and anti-inflammatory effects as well as the downregulation of NF-kappaB and TGF-beta/Smad signaling, probably via interference of ERK activation and/or enhancement of Nrf2, HO-1, and AMPK activity.	Rutin	42-47	NFE2 like bZIP transcription factor 2	Rattus norvegicus	263-267
24815012-13	2014	Taken together, the beneficial effects of rutin were shown to be associated with antioxidative and anti-inflammatory effects as well as the downregulation of NF-kappaB and TGF-beta/Smad signaling, probably via interference of ERK activation and/or enhancement of Nrf2, HO-1, and AMPK activity.	Rutin	42-47	heme oxygenase 1	Rattus norvegicus	269-273
24654784-8	2014	Knockdown of CBR1 expression with siRNA or inhibition of CBR1 activity with rutin decreased both basal and cortisol-stimulated PGF2alpha production in human amnion fibroblasts.	Rutin	76-81	carbonyl reductase 1	Homo sapiens	57-61
26031015-14	2014	Rutin administration to iron-overloaded rats resulted in significant decrease in serum total iron, TIBC, Tf, TS%, ferritin levels and AST and ALT activities and liver total iron, L-MDA and NO levels with significant increases in serum UIBC, albumin, total protein and total cholesterol levels and in liver GSH, CAT and SOD activities compared with the IOL group.	Rutin	0-5	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	134-137
26031015-14	2014	Rutin administration to iron-overloaded rats resulted in significant decrease in serum total iron, TIBC, Tf, TS%, ferritin levels and AST and ALT activities and liver total iron, L-MDA and NO levels with significant increases in serum UIBC, albumin, total protein and total cholesterol levels and in liver GSH, CAT and SOD activities compared with the IOL group.	Rutin	0-5	catalase	Rattus norvegicus	311-314
25187683-4	2014	Therefore, the predicted structure of HBx using threading in LOMET was used for docking against plant derived natural compounds (curcumin, oleanolic acid, resveratrol, bilobetin, luteoline, ellagic acid, betulinic acid and rutin) by Molegro Virtual Docker.	Rutin	223-228	X protein	Hepatitis B virus	38-41
25059040-1	2014	Administration of rutin (50 and 100 mg/kg) and pioglitazone (10 mg/kg) orally for 3 weeks treatment significantly improved body weight, reduced plasma glucose and glycosylated hemoglobin, pro-inflammatory cytokines (IL-6 and TNF-alpha), restored the depleted liver antioxidant status and serum lipid profile in high fat diet + streptozotocin induced type 2 diabetic rats.	Rutin	18-23	interleukin 6	Rattus norvegicus	216-220
25059040-1	2014	Administration of rutin (50 and 100 mg/kg) and pioglitazone (10 mg/kg) orally for 3 weeks treatment significantly improved body weight, reduced plasma glucose and glycosylated hemoglobin, pro-inflammatory cytokines (IL-6 and TNF-alpha), restored the depleted liver antioxidant status and serum lipid profile in high fat diet + streptozotocin induced type 2 diabetic rats.	Rutin	18-23	tumor necrosis factor	Rattus norvegicus	225-234
24668568-1	2014	SCOPE: We investigated whether rutin, a flavonoid isolated from Toona sinensis Roem, has the ability to enhance insulin-dependent receptor kinase (IRK) activity and glucose transporter 4 (GLUT4) translocation in differentiated myotubes.	Rutin	31-36	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	188-193
24668568-6	2014	CONCLUSION: This study shows evidence that rutin may serve as a potential agent for glycemic control through enhancement of IRK activity, thereby inducing the insulin signaling pathway causing increased GLUT4 translocation and increased glucose uptake.	Rutin	43-48	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	203-208
24353343-3	2014	Compared with the RG diet, the MYB10 diet contained elevated concentrations of the flavonoid subclasses anthocyanins, flavanol monomers (epicatechin) and oligomers (procyanidin B2), and flavonols (quercetin glycosides), but other plant secondary metabolites were largely unaltered.	Rutin	197-217	transcription factor MYB113-like	Malus domestica	31-36
24285294-6	2014	Rutin stimulated the uptake of estrone-3-sulfate (E-3-S), taurocholic acid (TCA), cholic acid (CA) and rosuvastatin by OATP2B1, but not p-coumaric acid or ferulic acid.	Rutin	0-5	solute carrier organic anion transporter family member 2B1	Homo sapiens	119-126
24285294-7	2014	The EC50 of rutin for transport by OATP2B1 was 2.32 mum.	Rutin	12-17	solute carrier organic anion transporter family member 2B1	Homo sapiens	35-42
24512768-0	2014	Rutin improves spatial memory in Alzheimer"s disease transgenic mice by reducing Abeta oligomer level and attenuating oxidative stress and neuroinflammation.	Rutin	0-5	amyloid beta (A4) precursor protein	Mus musculus	81-86
24512768-6	2014	Results demonstrated that orally administered rutin significantly attenuated memory deficits in AD transgenic mice, decreased oligomeric Abeta level, increased super oxide dismutase (SOD) activity and glutathione (GSH)/glutathione disulfide (GSSG) ratio, reduced GSSG and malondialdehyde (MDA) levels, downregulated microgliosis and astrocytosis, and decreased interleukin (IL)-1beta and IL-6 levels in the brain.	Rutin	46-51	amyloid beta (A4) precursor protein	Mus musculus	137-142
24512768-6	2014	Results demonstrated that orally administered rutin significantly attenuated memory deficits in AD transgenic mice, decreased oligomeric Abeta level, increased super oxide dismutase (SOD) activity and glutathione (GSH)/glutathione disulfide (GSSG) ratio, reduced GSSG and malondialdehyde (MDA) levels, downregulated microgliosis and astrocytosis, and decreased interleukin (IL)-1beta and IL-6 levels in the brain.	Rutin	46-51	interleukin 1 alpha	Mus musculus	361-383
24512768-6	2014	Results demonstrated that orally administered rutin significantly attenuated memory deficits in AD transgenic mice, decreased oligomeric Abeta level, increased super oxide dismutase (SOD) activity and glutathione (GSH)/glutathione disulfide (GSSG) ratio, reduced GSSG and malondialdehyde (MDA) levels, downregulated microgliosis and astrocytosis, and decreased interleukin (IL)-1beta and IL-6 levels in the brain.	Rutin	46-51	interleukin 6	Mus musculus	388-392
24512768-7	2014	These results indicated that rutin is a promising agent for AD treatment because of its antioxidant, anti-inflammatory, and reducing Abeta oligomer activities.	Rutin	29-34	amyloid beta (A4) precursor protein	Mus musculus	133-138
24507948-11	2014	In the rutin-treated group, MMP-9 expression and activity were significantly attenuated at 6, 24, and 48 h compared to the control group.	Rutin	7-12	matrix metallopeptidase 9	Rattus norvegicus	28-33
24285294-8	2014	The Km value of E-3-S for OATP2B1 in the presence of rutin (9.21 mum) was almost the same as that in the absence of rutin (8.53 mum).	Rutin	53-58	solute carrier organic anion transporter family member 2B1	Homo sapiens	26-33
24285294-9	2014	On the other hand, the Vmax of E-3-S transport by OATP2B1 in the presence of rutin (270 pmol/mg protein/min) was 1.2-fold higher than that in the absence of rutin (218 pmol/mg protein/min).	Rutin	77-82	solute carrier organic anion transporter family member 2B1	Homo sapiens	50-57
24285294-9	2014	On the other hand, the Vmax of E-3-S transport by OATP2B1 in the presence of rutin (270 pmol/mg protein/min) was 1.2-fold higher than that in the absence of rutin (218 pmol/mg protein/min).	Rutin	157-162	solute carrier organic anion transporter family member 2B1	Homo sapiens	50-57
24285294-10	2014	Moreover, the expression level of OATP2B1 on the cell membrane was increased by treatment with rutin for 5 min without alteration of the total OATP2B1 expression level.	Rutin	95-100	solute carrier organic anion transporter family member 2B1	Homo sapiens	34-41
24285294-12	2014	The stimulatory effect of rutin is a little weak but may affect the absorption of OATP2B1 substrates, because rutin is taken daily in foods and its intestinal concentration would reach the stimulatory range of OATP2B1.	Rutin	26-31	solute carrier organic anion transporter family member 2B1	Homo sapiens	82-89
24285294-12	2014	The stimulatory effect of rutin is a little weak but may affect the absorption of OATP2B1 substrates, because rutin is taken daily in foods and its intestinal concentration would reach the stimulatory range of OATP2B1.	Rutin	26-31	solute carrier organic anion transporter family member 2B1	Homo sapiens	210-217
24285294-12	2014	The stimulatory effect of rutin is a little weak but may affect the absorption of OATP2B1 substrates, because rutin is taken daily in foods and its intestinal concentration would reach the stimulatory range of OATP2B1.	Rutin	110-115	solute carrier organic anion transporter family member 2B1	Homo sapiens	82-89
24285294-12	2014	The stimulatory effect of rutin is a little weak but may affect the absorption of OATP2B1 substrates, because rutin is taken daily in foods and its intestinal concentration would reach the stimulatory range of OATP2B1.	Rutin	110-115	solute carrier organic anion transporter family member 2B1	Homo sapiens	210-217
24362044-7	2014	The efflux mechanism related with P-glycoprotein also existed with the polar flavonoids; verapamil could enhance the permeation of rutin and quercetin via inhibition of P-glycoprotein.	Rutin	131-136	ATP binding cassette subfamily B member 1	Homo sapiens	34-48
24362044-7	2014	The efflux mechanism related with P-glycoprotein also existed with the polar flavonoids; verapamil could enhance the permeation of rutin and quercetin via inhibition of P-glycoprotein.	Rutin	131-136	ATP binding cassette subfamily B member 1	Homo sapiens	169-183
24693223-10	2014	The application of 2D gel electrophoresis to analyze the rutin-responsive protein profiles in the WFST mouse brain further revealed the upregulation of the CB1 cannabinoid receptor-interacting protein 1, myelin basic protein, Rho GDP dissociation inhibitor (GDI) alpha, and TPI, indicating that rutin might inhibit anxiety through the upregulation of the expression of anxiety-associated proteins.	Rutin	57-62	cannabinoid receptor interacting protein 1	Mus musculus	156-202
24693223-10	2014	The application of 2D gel electrophoresis to analyze the rutin-responsive protein profiles in the WFST mouse brain further revealed the upregulation of the CB1 cannabinoid receptor-interacting protein 1, myelin basic protein, Rho GDP dissociation inhibitor (GDI) alpha, and TPI, indicating that rutin might inhibit anxiety through the upregulation of the expression of anxiety-associated proteins.	Rutin	57-62	myelin basic protein	Mus musculus	204-224
24693223-10	2014	The application of 2D gel electrophoresis to analyze the rutin-responsive protein profiles in the WFST mouse brain further revealed the upregulation of the CB1 cannabinoid receptor-interacting protein 1, myelin basic protein, Rho GDP dissociation inhibitor (GDI) alpha, and TPI, indicating that rutin might inhibit anxiety through the upregulation of the expression of anxiety-associated proteins.	Rutin	57-62	Rho GDP dissociation inhibitor (GDI) alpha	Mus musculus	226-268
24693223-10	2014	The application of 2D gel electrophoresis to analyze the rutin-responsive protein profiles in the WFST mouse brain further revealed the upregulation of the CB1 cannabinoid receptor-interacting protein 1, myelin basic protein, Rho GDP dissociation inhibitor (GDI) alpha, and TPI, indicating that rutin might inhibit anxiety through the upregulation of the expression of anxiety-associated proteins.	Rutin	57-62	triosephosphate isomerase 1	Mus musculus	274-277
24677236-6	2014	PDI as an antithrombotic target is being explored using isoquercetin and quercetin 3-rutinoside, inhibitors of PDI identified by high throughput screening.	Rutin	73-95	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	0-3
24677236-6	2014	PDI as an antithrombotic target is being explored using isoquercetin and quercetin 3-rutinoside, inhibitors of PDI identified by high throughput screening.	Rutin	73-95	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	111-114
24468619-14	2014	Conclusions: Collectively, the present results show that AE and its constituent rutin produced antinociceptive and antiedematogenic action in models of acute and persistent inflammatory nociception and it seems to be related to the inhibition of TRPA1 receptor activation.	Rutin	80-85	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	246-251
24479689-6	2014	Moreover, an integrated in silico approach for the prediction of Phase I metabolism of the flavonoids quercetin, rutin, naringenin and naringin, which provided useful information about the most likely metabolites of these flavonoids and their interactions with amino acid residues of CYP2C9, is described.	Rutin	113-118	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	284-290
24148604-3	2014	We assessed the effect of rutin (3,3",4",5,7-pentahydroxyflavone-3-rhamnoglucoside) on the mitogen-activated protein kinase (MAPK) pathway, memory retrieval and oxidative stress in rats injected with beta-amyloid (Abeta), which is implicated to have an important role in Alzheimer"s disease (AD).	Rutin	26-31	mitogen activated protein kinase 3	Rattus norvegicus	125-129
24076399-5	2013	In particular, the high inclusion of rutin in the pores of NH2-MCM-41 was assessed by XRD, TGA, gas-volumetric analysis (BET), while FTIR spectroscopy allowed to analyse with great detail the molecular interaction with the inorganic surface.	Rutin	37-42	T-box transcription factor 1	Homo sapiens	91-94
25478064-2	2014	The purpose of the study is to evaluate the hepatoprotective effect of rutin in carbon tetrachloride- (CCl4-) induced liver injuries in rat model.	Rutin	71-76	C-C motif chemokine ligand 4	Rattus norvegicus	103-107
25478064-13	2014	Interestingly, rutin supplementation completely reversed the biochemical and gene expression levels induced by CCl4 to control values.	Rutin	15-20	C-C motif chemokine ligand 4	Rattus norvegicus	111-115
24892140-0	2013	Modulatory effects of quercetin and rutin on the activity, expression and inducibility of CYP1A1 in intestinal HCT-8 cells.	Rutin	36-41	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	90-96
24076399-5	2013	In particular, the high inclusion of rutin in the pores of NH2-MCM-41 was assessed by XRD, TGA, gas-volumetric analysis (BET), while FTIR spectroscopy allowed to analyse with great detail the molecular interaction with the inorganic surface.	Rutin	37-42	delta/notch like EGF repeat containing	Homo sapiens	121-124
24117263-6	2013	Furthermore, overexpression of transforming growth factor beta1 (TGF-beta1), connective tissue growth factor (CTGF), and excessive deposition of extracellular matrix (ECM) in isoproterenol-treated myocardial tissues were normalized by quercetin and rutin.	Rutin	249-254	transforming growth factor, beta 1	Rattus norvegicus	31-63
24021351-6	2013	Rutin also attenuated B[a]PDE-induced Raf/MEK/ERK and Akt activation, but had no effect on the phosphorylation of EGFR.	Rutin	0-5	zinc fingers and homeoboxes 2	Mus musculus	38-41
24021351-6	2013	Rutin also attenuated B[a]PDE-induced Raf/MEK/ERK and Akt activation, but had no effect on the phosphorylation of EGFR.	Rutin	0-5	midkine	Mus musculus	42-45
24021351-6	2013	Rutin also attenuated B[a]PDE-induced Raf/MEK/ERK and Akt activation, but had no effect on the phosphorylation of EGFR.	Rutin	0-5	mitogen-activated protein kinase 1	Mus musculus	46-49
24021351-6	2013	Rutin also attenuated B[a]PDE-induced Raf/MEK/ERK and Akt activation, but had no effect on the phosphorylation of EGFR.	Rutin	0-5	thymoma viral proto-oncogene 1	Mus musculus	54-57
24021351-11	2013	Collectively, rutin inhibits B[a]PDE-induced COX-2 expression by suppressing the Raf/MEK/ERK and Akt signaling pathways.	Rutin	14-19	cytochrome c oxidase II, mitochondrial	Mus musculus	45-50
24021351-11	2013	Collectively, rutin inhibits B[a]PDE-induced COX-2 expression by suppressing the Raf/MEK/ERK and Akt signaling pathways.	Rutin	14-19	zinc fingers and homeoboxes 2	Mus musculus	81-84
24021351-11	2013	Collectively, rutin inhibits B[a]PDE-induced COX-2 expression by suppressing the Raf/MEK/ERK and Akt signaling pathways.	Rutin	14-19	midkine	Mus musculus	85-88
24021351-11	2013	Collectively, rutin inhibits B[a]PDE-induced COX-2 expression by suppressing the Raf/MEK/ERK and Akt signaling pathways.	Rutin	14-19	mitogen-activated protein kinase 1	Mus musculus	89-92
24021351-11	2013	Collectively, rutin inhibits B[a]PDE-induced COX-2 expression by suppressing the Raf/MEK/ERK and Akt signaling pathways.	Rutin	14-19	thymoma viral proto-oncogene 1	Mus musculus	97-100
24198722-4	2013	P-glycoprotein and multidrug-resistant proteins 2 and 3 were involved in the transmembrane transport and intracellular accumulation of rutin by Caco-2 cells.	Rutin	135-140	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
24117263-5	2013	The administration of quercetin and rutin signifcantly decreased the cardiac weight index and myocardial enzyme activity, increased the activity of superoxide dismutase in the serum, and inhibited the ISO-induced increase in angiotensin II and aldosterone in the plasma.	Rutin	36-41	angiotensinogen	Rattus norvegicus	225-239
23837585-0	2013	Involvement of GLUT-4 in the stimulatory effect of rutin on glucose uptake in rat soleus muscle.	Rutin	51-56	solute carrier family 2 member 4	Rattus norvegicus	15-21
23541171-6	2013	A recent high-throughput screening identified the commonly ingested flavonoid, quercetin-3-rutinoside, as an inhibitor of PDI.	Rutin	79-101	prolyl 4-hydroxylase subunit beta	Homo sapiens	122-125
23867787-9	2013	RTN 20 mg/kg, the highest dose tested, lacked toxic effects on body weight and relative organ weight in mice, increased mean survival time by 50 days, and decreased by 55% the VEGF serum levels compared to untreated mice.	Rutin	0-3	vascular endothelial growth factor A	Mus musculus	176-180
23560676-0	2013	On the repair of oxidative damage to apoferritin: a model study with the flavonoids quercetin and rutin in aerated and deaerated solutions.	Rutin	98-103	ferritin heavy chain	Equus caballus	37-48
23560676-3	2013	To elucidate the potential pathways to Ft recovery, repair of oxidative damage to horse spleen apoferritin (apoFt) and Ft by quercetin (QH) or rutin (RH) was studied in the presence and absence of oxygen.	Rutin	143-148	ferritin heavy chain	Equus caballus	95-106
23670213-9	2013	Furthermore, there was marked activation of antioxidant enzymes including superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), and total glutathione (GSH) in rutin pretreated cells compared to cells incubated with 6-OHDA alone.	Rutin	173-178	catalase	Rattus norvegicus	102-110
23271130-11	2013	The results of HPLC revealed that a new substance was formed by mixing 20E with the recombinant UGT86 protein in vitro, indicating that the effect of Ugt86 on 20E was similar to that on exogenous quercetin derived from plant food, and that the effect probably initiated the detoxification reaction against rutin.	Rutin	306-311	UDP-glucosyltransferase	Bombyx mori	96-101
23627470-9	2013	Also, the elevation of inducible NO synthase (iNOS) activity as well as the decrease of constitutive NO synthase (cNOS) in the gastric mucosa were significantly prevented by rutin pretreatment.	Rutin	174-179	nitric oxide synthase 2	Rattus norvegicus	23-44
23627470-9	2013	Also, the elevation of inducible NO synthase (iNOS) activity as well as the decrease of constitutive NO synthase (cNOS) in the gastric mucosa were significantly prevented by rutin pretreatment.	Rutin	174-179	nitric oxide synthase 2	Rattus norvegicus	46-50
23627470-9	2013	Also, the elevation of inducible NO synthase (iNOS) activity as well as the decrease of constitutive NO synthase (cNOS) in the gastric mucosa were significantly prevented by rutin pretreatment.	Rutin	174-179	nitric oxide synthase 3	Rattus norvegicus	114-118
23773725-5	2013	RESULTS: Rutin in combination with HCD induced a significant protective effect against the hepatotoxicity by reducing the plasma level of alanine transaminase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL).	Rutin	9-14	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	166-192
23773725-5	2013	RESULTS: Rutin in combination with HCD induced a significant protective effect against the hepatotoxicity by reducing the plasma level of alanine transaminase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL).	Rutin	9-14	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	194-197
23499857-4	2013	Cytotoxicity could be prevented by the myeloperoxidase inhibitor rutin, but not by the cytochrome P450 inhibitor ketoconazole.	Rutin	65-70	myeloperoxidase	Homo sapiens	39-54
22733206-9	2012	KEY MESSAGE: Tobacco callus cultures expressing AtMYB12 accumulate enhanced content of rutin and can be used as a potential alternative source of rutin as well as biopesticides against insect pests.	Rutin	146-151	myb domain protein 12	Arabidopsis thaliana	48-55
23467948-9	2013	RESULTS: Quercetin (50 mg/kg) and rutin (10 mg/kg) administered 10 min before reperfusion resulted in significant reduction of infarct size, MDA, and MPO levels and significant increase in SOD and CAT levels.	Rutin	34-39	myeloperoxidase	Rattus norvegicus	150-153
23467948-9	2013	RESULTS: Quercetin (50 mg/kg) and rutin (10 mg/kg) administered 10 min before reperfusion resulted in significant reduction of infarct size, MDA, and MPO levels and significant increase in SOD and CAT levels.	Rutin	34-39	catalase	Rattus norvegicus	197-200
23088714-4	2012	HFDP cell incubation with staurosporine caused apoptosis, which was completely inhibited by exposure to rutin (2.2 muM), spermidine (1 muM) and zeaxanthin (80 muM).	Rutin	104-109	latexin	Homo sapiens	115-118
23222934-6	2012	Inhibited the endothelial nitric oxide synthase (eNOS) by NG-Nitro-L-arginine Methyl Ester (L-NAME) or removed the PA endothelium would decrease the relaxation effect of rutin.	Rutin	170-175	nitric oxide synthase 3	Bos taurus	14-47
23117480-2	2012	In this study, we aim to investigate the phenylalanine ammonia-lyase (PAL) and the quercetin-3-O-glucosyl transferase (3-GT) reactions in the formation of rutin during tomato fruit ripening.	Rutin	155-160	phenylalanine ammonia-lyase	Solanum lycopersicum	41-68
23117480-2	2012	In this study, we aim to investigate the phenylalanine ammonia-lyase (PAL) and the quercetin-3-O-glucosyl transferase (3-GT) reactions in the formation of rutin during tomato fruit ripening.	Rutin	155-160	phenylalanine ammonia-lyase	Solanum lycopersicum	70-73
23064111-5	2012	Lipid peroxidation was decreased in samples treated with 30 muM quercetin (P&lt;0.01) and 30 muM rutin (P&lt;0.05) versus samples incubated with tert-butylhydroperoxide alone.	Rutin	97-102	latexin	Homo sapiens	93-96
22733206-8	2012	This study suggests the biotechnological potential of AtMYB12-expressing callus cultures for the production of rutin, which can be used for biopesticide formulations against insect pests.	Rutin	111-116	myb domain protein 12	Arabidopsis thaliana	54-61
22733206-9	2012	KEY MESSAGE: Tobacco callus cultures expressing AtMYB12 accumulate enhanced content of rutin and can be used as a potential alternative source of rutin as well as biopesticides against insect pests.	Rutin	87-92	myb domain protein 12	Arabidopsis thaliana	48-55
23395857-8	2013	Also, rutin-induced glucose uptake via CaMKII may result in GLUT-4 translocation to the plasma membrane, characterizing an insulin-independent pathway.	Rutin	6-11	solute carrier family 2 member 4	Rattus norvegicus	60-66
23315166-6	2013	Blockade of free thiols, an inhibitory monoclonal antibody to protein disulfide isomerase (PDI), and the small-molecule PDI antagonist quercetin-3-rutinoside prevented ATG-mediated TF activation, and C5 complement activation resulted in oxidation of cell surface PDI.	Rutin	135-157	prolyl 4-hydroxylase subunit beta	Homo sapiens	120-123
23315166-6	2013	Blockade of free thiols, an inhibitory monoclonal antibody to protein disulfide isomerase (PDI), and the small-molecule PDI antagonist quercetin-3-rutinoside prevented ATG-mediated TF activation, and C5 complement activation resulted in oxidation of cell surface PDI.	Rutin	135-157	prolyl 4-hydroxylase subunit beta	Homo sapiens	120-123
23187035-2	2013	We investigated whether rutin inhibits inducible nitric oxide synthase (iNOS) and reduces 3-nitrotyrosine (3-NT) formation in the kidneys of rats during I/R.	Rutin	24-29	nitric oxide synthase 2	Rattus norvegicus	39-70
23187035-2	2013	We investigated whether rutin inhibits inducible nitric oxide synthase (iNOS) and reduces 3-nitrotyrosine (3-NT) formation in the kidneys of rats during I/R.	Rutin	24-29	nitric oxide synthase 2	Rattus norvegicus	72-76
23000098-9	2012	SIGNIFICANCE: The preventive effect of rutin on the development of DN is closely related to oxidative stress and the TGF-beta(1)/Smad/ECM and TGF-beta(1)/CTGF/ECM signaling pathways.	Rutin	39-44	transforming growth factor, beta 1	Rattus norvegicus	117-128
23000098-9	2012	SIGNIFICANCE: The preventive effect of rutin on the development of DN is closely related to oxidative stress and the TGF-beta(1)/Smad/ECM and TGF-beta(1)/CTGF/ECM signaling pathways.	Rutin	39-44	transforming growth factor, beta 1	Rattus norvegicus	142-153
23000098-9	2012	SIGNIFICANCE: The preventive effect of rutin on the development of DN is closely related to oxidative stress and the TGF-beta(1)/Smad/ECM and TGF-beta(1)/CTGF/ECM signaling pathways.	Rutin	39-44	cellular communication network factor 2	Rattus norvegicus	154-158
22422552-0	2012	Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells.	Rutin	11-31	aryl hydrocarbon receptor	Homo sapiens	80-83
22422552-0	2012	Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells.	Rutin	11-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	99-105
23043521-2	2012	In the present study the hepatoprotective effect of rutin was evaluated against carbon tetrachloride (CCl4)-induced liver injuries in rats.	Rutin	52-57	C-C motif chemokine ligand 4	Rattus norvegicus	102-106
23043521-7	2012	Protective effect of rutin on serum enzyme level, lipid profile, activities of antioxidant enzymes and molecular markers were calculated in CCl4-induced hepatotoxicity in rat.	Rutin	21-26	C-C motif chemokine ligand 4	Rattus norvegicus	140-144
22902988-10	2012	The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin.	Rutin	89-94	nitric oxide synthase 2, inducible	Mus musculus	18-49
22902988-10	2012	The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin.	Rutin	89-94	nitric oxide synthase 2, inducible	Mus musculus	51-55
22426011-0	2012	Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats.	Rutin	27-32	NLR family, pyrin domain containing 3	Rattus norvegicus	50-55
22426011-5	2012	The restoration of fructose-induced hyperuricemia and dyslipidemia by the treatment of allopurinol, quercetin and rutin blocked the NLRP3 inflammasome activation to improve the signaling impairments and reduce lipid accumulation in the kidney of rats.	Rutin	114-119	NLR family, pyrin domain containing 3	Rattus norvegicus	132-137
22565308-5	2012	A high-throughput screen identified quercetin-3-rutinoside as an inhibitor of PDI reductase activity in vitro.	Rutin	36-58	prolyl 4-hydroxylase subunit beta	Homo sapiens	78-81
22426011-7	2012	The NLRP3 inflammasome may be the target mediating the improvement of urate-lowering agents allopurinol, quercetin and rutin on fructose-induced renal lipid accumulation and injury.	Rutin	119-124	NLR family, pyrin domain containing 3	Rattus norvegicus	4-9
22565308-6	2012	Inhibition of PDI was selective, as quercetin-3-rutinoside failed to inhibit the reductase activity of several other thiol isomerases found in the vasculature.	Rutin	36-58	prolyl 4-hydroxylase subunit beta	Homo sapiens	14-17
22565308-8	2012	Using intravital microscopy in mice, we demonstrated that quercetin-3-rutinoside blocks thrombus formation in vivo by inhibiting PDI.	Rutin	58-80	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	129-132
22565308-9	2012	Infusion of recombinant PDI reversed the antithrombotic effect of quercetin-3-rutinoside.	Rutin	66-88	prolyl 4-hydroxylase subunit beta	Homo sapiens	24-27
22588834-0	2012	Effects of rutin on the expression of PPARgamma in skeletal muscles of db/db mice.	Rutin	11-16	peroxisome proliferator activated receptor gamma	Mus musculus	38-47
23167799-8	2012	Here, we describe a combination of approaches to outline and characterize the role of two flavonoids, quercetin and rutin, on Wnt/beta-catenin signaling, using Xenopus embryos as an experimental model.	Rutin	116-121	catenin beta 1 L homeolog	Xenopus laevis	130-142
22441036-6	2012	Rutin pretreatment (25 mg/kg, orally, once daily for 3 weeks) significantly attenuated thiobarbituric acid reactive substances (TBARS), activity of poly ADP-ribosyl polymerase, and nitrite level and decreased level of reduced glutathione (GSH) and activities of its dependent enzymes (glutathione peroxidase [GPx] and glutathione reductase [GR]) and catalase in the hippocampus of ICV-STZ rats.	Rutin	0-5	glutathione-disulfide reductase	Rattus norvegicus	318-339
22441036-6	2012	Rutin pretreatment (25 mg/kg, orally, once daily for 3 weeks) significantly attenuated thiobarbituric acid reactive substances (TBARS), activity of poly ADP-ribosyl polymerase, and nitrite level and decreased level of reduced glutathione (GSH) and activities of its dependent enzymes (glutathione peroxidase [GPx] and glutathione reductase [GR]) and catalase in the hippocampus of ICV-STZ rats.	Rutin	0-5	glutathione-disulfide reductase	Rattus norvegicus	341-343
22159164-11	2012	Other HSA-based NTs having an alpha-glucosidase inner wall hydrolysed a glucopyranoside to yield alpha-D-glucose.	Rutin	72-87	albumin	Homo sapiens	6-9
22548048-4	2012	Results indicated that EEB, rutin, and quercetin + rutin significantly improved 2-NBDG uptake via promoting Akt phosphorylation and preventing PPARgamma degradation caused by high-glucose induction for 48 h in FL83B hepatocytes.	Rutin	28-33	peroxisome proliferator activated receptor gamma	Mus musculus	143-152
22548048-4	2012	Results indicated that EEB, rutin, and quercetin + rutin significantly improved 2-NBDG uptake via promoting Akt phosphorylation and preventing PPARgamma degradation caused by high-glucose induction for 48 h in FL83B hepatocytes.	Rutin	51-56	peroxisome proliferator activated receptor gamma	Mus musculus	143-152
21617331-0	2011	Orally administered rutin inhibits the gene expression of Th2 cytokines in the gut and lung in aged mice.	Rutin	20-25	heart and neural crest derivatives expressed 2	Mus musculus	58-61
22292957-4	2012	A 10 ns molecular dynamics simulation showed that one copper ion at the tyrosinase active site was responsible for the interaction with rutin.	Rutin	136-141	tyrosinase	Homo sapiens	72-82
22292957-7	2012	Measurements of intrinsic and ANS-binding fluorescences showed that rutin showed a relatively strong binding affinity for tyrosinase and one possible binding site that could be a copper was detected accompanying with a hydrophobic exposure of tyrosinase.	Rutin	68-73	tyrosinase	Homo sapiens	122-132
22292957-7	2012	Measurements of intrinsic and ANS-binding fluorescences showed that rutin showed a relatively strong binding affinity for tyrosinase and one possible binding site that could be a copper was detected accompanying with a hydrophobic exposure of tyrosinase.	Rutin	68-73	tyrosinase	Homo sapiens	243-253
21924266-0	2011	Complex formation of rutin and quercetin with copper alters the mode of inhibition of ribonuclease A.	Rutin	21-26	ribonuclease A family member 1, pancreatic	Homo sapiens	86-100
21924266-1	2011	Rutin and quercetin, both minor components of green tea and their Cu(II) complexes interact with Ribonuclease A (RNase A) in a novel way.	Rutin	0-5	ribonuclease A family member 1, pancreatic	Homo sapiens	97-111
21924266-1	2011	Rutin and quercetin, both minor components of green tea and their Cu(II) complexes interact with Ribonuclease A (RNase A) in a novel way.	Rutin	0-5	ribonuclease A family member 1, pancreatic	Homo sapiens	113-120
21617331-11	2011	Thus, rutin might be effective against a Th2-dominant profile through NOS2 inhibition in aged mice.	Rutin	6-11	heart and neural crest derivatives expressed 2	Mus musculus	41-44
21617331-11	2011	Thus, rutin might be effective against a Th2-dominant profile through NOS2 inhibition in aged mice.	Rutin	6-11	nitric oxide synthase 2, inducible	Mus musculus	70-74
21513789-9	2011	This toxicity can be completely rescued via incubation with rutin, an inhibitor of MPO.	Rutin	60-65	myeloperoxidase	Rattus norvegicus	83-86
21605616-6	2011	We found that the beneficial effect of rutin pretreatment is mediated partially by its inhibitory effect on NFkappaB and TNF-alpha pathway mediated inflammation, caspase-3 mediated-tubular cell apoptosis, as well as by restoration of histopathological changes against cisplatin administration.	Rutin	39-44	caspase 3	Rattus norvegicus	162-171
21600261-2	2011	In the present study, we assessed the effects of the flavonoids Genistein, Apigenin, Quercetin, Rutin and Astilbin on xanthine oxidase (XO) activities in vitro, and in serum and the liver.	Rutin	96-101	xanthine dehydrogenase	Mus musculus	118-134
21605616-5	2011	Rutin pretreatment prevented deteriorative effects induced by cisplatin through a protective mechanism that involved reduction of increased oxidative stress as well as caspase-3, TNF-alpha and NFkappaB protein expression levels.	Rutin	0-5	caspase 3	Rattus norvegicus	168-177
21605616-5	2011	Rutin pretreatment prevented deteriorative effects induced by cisplatin through a protective mechanism that involved reduction of increased oxidative stress as well as caspase-3, TNF-alpha and NFkappaB protein expression levels.	Rutin	0-5	tumor necrosis factor	Rattus norvegicus	179-188
21605616-6	2011	We found that the beneficial effect of rutin pretreatment is mediated partially by its inhibitory effect on NFkappaB and TNF-alpha pathway mediated inflammation, caspase-3 mediated-tubular cell apoptosis, as well as by restoration of histopathological changes against cisplatin administration.	Rutin	39-44	tumor necrosis factor	Rattus norvegicus	121-130
20727014-7	2011	Rutin supplementation along with ethanol significantly decreased the levels of liver marker enzymes, lipid peroxidation and significantly elevated the activities of liver SOD, CAT, GSH, glutathione peroxidase, vitamins C and E when compared to untreated ethanol supplemented rats.	Rutin	0-5	catalase	Rattus norvegicus	176-179
23140679-2	2011	We observed that rutin (50-100muM) reduced proliferation and viability of GL-15 cells, leading to decreased levels of ERK1/2 phosphorylation (P-ERK1/2) and accumulation of cells in the G2 phase of the cell cycle.	Rutin	17-22	mitogen-activated protein kinase 3	Homo sapiens	118-124
23140679-2	2011	We observed that rutin (50-100muM) reduced proliferation and viability of GL-15 cells, leading to decreased levels of ERK1/2 phosphorylation (P-ERK1/2) and accumulation of cells in the G2 phase of the cell cycle.	Rutin	17-22	mitogen-activated protein kinase 3	Homo sapiens	144-150
23140679-5	2011	Moreover, the remaining cells that were treated with 50muM rutin presented a morphological pattern of astroglial differentiation in culture, characterised by a condensed cell body and thin processes with overexpression of GFAP.	Rutin	59-64	glial fibrillary acidic protein	Homo sapiens	222-226
24250392-6	2011	In the treatment groups, both Rutin and Naringin in combination with insulin treatment in diabetic rats produced protection from diabetes and improved all the sperm parameters, decreased the MDA levels and increased the SOD and catalase levels.	Rutin	30-35	catalase	Rattus norvegicus	228-236
21763845-10	2011	The rats treated with rutin had a significant decrease in malondialdehyde level and had significant increases in superoxide dismutase, catalase activities, and spermatogenesis in ipsilateral testes, compared with torsion-detorsion group.	Rutin	22-27	catalase	Rattus norvegicus	135-143
21466223-8	2011	In conclusion, quercetin and rutin decreased the bioavailability of CSP through activating P-gp and CYP3A.	Rutin	29-34	ATP binding cassette subfamily B member 1	Homo sapiens	91-95
21170924-5	2011	VEGF and TGF-beta1 levels were dosed by ELISA in a GL-15 cell line treated with bevacizumab and also with the flavonoids rutin, 5-hydroxy-7,4"-dimethoxyflavone, casticin, apigenin and penduletin.	Rutin	121-126	vascular endothelial growth factor A	Homo sapiens	0-4
21170924-5	2011	VEGF and TGF-beta1 levels were dosed by ELISA in a GL-15 cell line treated with bevacizumab and also with the flavonoids rutin, 5-hydroxy-7,4"-dimethoxyflavone, casticin, apigenin and penduletin.	Rutin	121-126	transforming growth factor beta 1	Homo sapiens	9-18
21466223-0	2011	Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4.	Rutin	14-19	ATP binding cassette subfamily B member 1	Homo sapiens	118-132
21466223-0	2011	Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4.	Rutin	14-19	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	137-144
21466223-7	2011	The in vitro studies indicated that the quercetin and rutin induced the functions of P-gp and CYP3A4.	Rutin	54-59	ATP binding cassette subfamily B member 1	Homo sapiens	85-89
21466223-7	2011	The in vitro studies indicated that the quercetin and rutin induced the functions of P-gp and CYP3A4.	Rutin	54-59	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	94-100
21466223-8	2011	In conclusion, quercetin and rutin decreased the bioavailability of CSP through activating P-gp and CYP3A.	Rutin	29-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	100-105
21535797-7	2011	The expression of critical molecule involved in lipid synthesis, sterol regulatory element binding proteins-1 (SREBP-1), was attenuated in rutin-treated cells.	Rutin	139-144	sterol regulatory element binding transcription factor 1	Homo sapiens	65-109
21210103-10	2011	Pycnoporus laccase and Suberase  oligorutins led to an inhibition of COX-2 of about 35% and 70%, respectively, while monomeric rutin showed a near-negligible inhibition effect, less than about 10%.	Rutin	38-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
21207116-9	2011	It is noteworthy to observe that the main compounds present in the ASc, as gallic acid (the major component), chlorogenic acid and rutin, might be the responsible for such benefit, since they were found to display antioxidant properties.	Rutin	131-136	PYD and CARD domain containing	Rattus norvegicus	67-70
21535797-7	2011	The expression of critical molecule involved in lipid synthesis, sterol regulatory element binding proteins-1 (SREBP-1), was attenuated in rutin-treated cells.	Rutin	139-144	sterol regulatory element binding transcription factor 1	Homo sapiens	111-118
21425674-1	2011	Quercetin, kaempferol and to a lesser extent rutin have been reported to have antidiabetic activities when assessed by various assay models including in vitro alpha-glucosidase inhibition studies.	Rutin	45-50	sucrase-isomaltase	Homo sapiens	159-176
21150830-4	2010	High performance liquid chromatography (HPLC) and LC/MS analysis showed that the main active compounds in P-60 were phenols, such as caffeic acid, rosmarinic acid, rutin and quercetin.	Rutin	164-169	plasma protein 1	Mus musculus	106-110
21207318-5	2011	Moreover, catechin (1 muM), quercetin, myricetin, rutin, EGCG, and chrysin increased uptake of (14)C-BT (20 mM), whereas catechin (0.1 muM) decreased it.	Rutin	50-55	latexin	Homo sapiens	135-138
21446521-5	2011	Moreover, the electrical resistivity of the Ru0.67-TiN0.33 thin films is sufficiently low at 190 microomega x cm and was maintained even after O2 annealing at 750 degrees C. Therefore, Ru-TiN thin films can be utilized as a oxygen diffusion barrier material for future dynamic (DRAM) and ferroelectric (FeRAM) random access memory capacitors.	Rutin	185-191	DNA damage regulated autophagy modulator 1	Homo sapiens	278-282
19803520-0	2009	Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells.	Rutin	36-41	insulin receptor substrate 2	Rattus norvegicus	88-92
20051261-9	2010	CONCLUSION: Our results indicate that catechol and rutin, but not hesperidin, are primary bioactive phenolic compounds in the crude extract to suppress NO production in LPS-stimulated macrophages via NF-kappaB-dependent iNOS gene transcription.	Rutin	51-56	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	200-209
20051261-9	2010	CONCLUSION: Our results indicate that catechol and rutin, but not hesperidin, are primary bioactive phenolic compounds in the crude extract to suppress NO production in LPS-stimulated macrophages via NF-kappaB-dependent iNOS gene transcription.	Rutin	51-56	nitric oxide synthase 2, inducible	Mus musculus	220-224
19932588-9	2010	Rutin prevents changes in the activities of ALT, AST and LDH in the serum, liver and heart, indicating the protective effect of rutin against the hepatic and cardiac toxicity caused by STZ.	Rutin	0-5	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	49-52
20684240-3	2010	Glycosylated flavonoids: rutin, naringin, baikalin and methylhesperidin were shown to inhibit furin at pH 7.2 reversibly and competitively with Ki- 80-200 microM.	Rutin	25-30	furin, paired basic amino acid cleaving enzyme	Homo sapiens	94-99
20015448-0	2010	Vitamin E and rutin synergistically inhibit expression of vascular endothelial growth factor through down-regulation of binding activity of activator protein-1 in human promyelocytic leukemia (HL-60) cells.	Rutin	14-19	vascular endothelial growth factor A	Homo sapiens	58-92
20015448-0	2010	Vitamin E and rutin synergistically inhibit expression of vascular endothelial growth factor through down-regulation of binding activity of activator protein-1 in human promyelocytic leukemia (HL-60) cells.	Rutin	14-19	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-159
20033231-3	2010	In hp-1 peel, a twofold higher level of rutin and an earlier accumulation of flavonoids than in wild-type were observed, which correlated to the earlier activation of most flavonoid biosynthetic genes compared to wild-type.	Rutin	40-45	DNA damage-binding protein 1	Solanum lycopersicum	3-7
20730955-4	2010	Rutin and kaempferol also exhibited lipoxygenase-1 inhibitory activity, but to a much lesser extent than quercetin.	Rutin	0-5	seed linoleate 13S-lipoxygenase-1	Glycine max	36-50
19803520-4	2009	EGCG and Rutin could preserve the insulin secretory machinery and stimulate insulin receptor substrate 2 (IRS2) signaling in rat pancreatic beta cells, RIN-m5F.	Rutin	9-14	insulin receptor substrate 2	Rattus norvegicus	76-104
19803520-4	2009	EGCG and Rutin could preserve the insulin secretory machinery and stimulate insulin receptor substrate 2 (IRS2) signaling in rat pancreatic beta cells, RIN-m5F.	Rutin	9-14	insulin receptor substrate 2	Rattus norvegicus	106-110
19362115-0	2009	Rutin from Lonicera japonica inhibits myocardial ischemia/reperfusion-induced apoptosis in vivo and protects H9c2 cells against hydrogen peroxide-mediated injury via ERK1/2 and PI3K/Akt signals in vitro.	Rutin	0-5	mitogen activated protein kinase 3	Rattus norvegicus	166-172
19362115-0	2009	Rutin from Lonicera japonica inhibits myocardial ischemia/reperfusion-induced apoptosis in vivo and protects H9c2 cells against hydrogen peroxide-mediated injury via ERK1/2 and PI3K/Akt signals in vitro.	Rutin	0-5	AKT serine/threonine kinase 1	Rattus norvegicus	182-185
19362115-4	2009	The protective effect of rutin was inhibited not by JNK inhibitor or p38 MAPK inhibitor but by PI3K inhibitor or ERK inhibitor.	Rutin	25-30	mitogen-activated protein kinase 8	Rattus norvegicus	52-55
19362115-4	2009	The protective effect of rutin was inhibited not by JNK inhibitor or p38 MAPK inhibitor but by PI3K inhibitor or ERK inhibitor.	Rutin	25-30	Eph receptor B1	Rattus norvegicus	113-116
19362115-8	2009	Rutin administration also inhibited apoptosis in myocardial tissues in I/R rats by increasing Bcl-2/bax ratio and decreasing active caspase-3 expression.	Rutin	0-5	BCL2, apoptosis regulator	Rattus norvegicus	94-99
19362115-8	2009	Rutin administration also inhibited apoptosis in myocardial tissues in I/R rats by increasing Bcl-2/bax ratio and decreasing active caspase-3 expression.	Rutin	0-5	BCL2 associated X, apoptosis regulator	Rattus norvegicus	100-103
19362115-8	2009	Rutin administration also inhibited apoptosis in myocardial tissues in I/R rats by increasing Bcl-2/bax ratio and decreasing active caspase-3 expression.	Rutin	0-5	caspase 3	Rattus norvegicus	132-141
19434676-3	2009	The selective artificial receptors for glucopyranoside were fully characterized by IR, TEM and BET analyses, and their molecular recognition abilities by binding experiments carried out in batch processes.	Rutin	39-54	delta/notch like EGF repeat containing	Homo sapiens	95-98
19010542-5	2009	The effects of rutin on WEHI-3 in BALB/c mice in vivo were also examined and the results indicated that rutin decreased the percentage of Mac-3 marker, indicating that the differentiation of the precursor of macrophage and T cells was inhibited.	Rutin	104-109	lysosomal-associated membrane protein 2	Mus musculus	138-143
19271503-2	2008	The results showed that rutin had hardly effect on the serum protein conformation, but influenced the secondary structure of serum albumin (SA) molecule with the addition of rutin into BSA and HSA solution.	Rutin	24-29	albumin	Homo sapiens	125-138
19196000-0	2009	Blockade of oxidized LDL-triggered endothelial apoptosis by quercetin and rutin through differential signaling pathways involving JAK2.	Rutin	74-79	Janus kinase 2	Homo sapiens	130-134
19196000-7	2009	Unlike quercetin, rutin blocked the activation of oxidized LDL-induced JNK and p38 MAPK as well as the upstream ASK1 phosphorylation.	Rutin	18-23	mitogen-activated protein kinase 8	Homo sapiens	71-74
19196000-7	2009	Unlike quercetin, rutin blocked the activation of oxidized LDL-induced JNK and p38 MAPK as well as the upstream ASK1 phosphorylation.	Rutin	18-23	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	112-116
19196000-8	2009	Quercetin dose-dependently attenuated the JAK2 phosphorylation evoked by oxidized LDL, whereas rutin abolished the JAK signaling accompanying nuclear transactivation of STAT3 and enhanced the JAK activity-inhibiting SOCS3 expression.	Rutin	95-100	signal transducer and activator of transcription 3	Homo sapiens	169-174
19196000-8	2009	Quercetin dose-dependently attenuated the JAK2 phosphorylation evoked by oxidized LDL, whereas rutin abolished the JAK signaling accompanying nuclear transactivation of STAT3 and enhanced the JAK activity-inhibiting SOCS3 expression.	Rutin	95-100	suppressor of cytokine signaling 3	Homo sapiens	216-221
19196000-10	2009	These results suggest that quercetin and rutin inhibit Cu(2+)-oxidized LDL-induced endothelial apoptosis through modulating JAK2-STAT3 pathways and that rutin may modulate a signaling crosstalk between JAK2 and MAPK.	Rutin	41-46	Janus kinase 2	Homo sapiens	124-128
19196000-10	2009	These results suggest that quercetin and rutin inhibit Cu(2+)-oxidized LDL-induced endothelial apoptosis through modulating JAK2-STAT3 pathways and that rutin may modulate a signaling crosstalk between JAK2 and MAPK.	Rutin	41-46	signal transducer and activator of transcription 3	Homo sapiens	129-134
19196000-10	2009	These results suggest that quercetin and rutin inhibit Cu(2+)-oxidized LDL-induced endothelial apoptosis through modulating JAK2-STAT3 pathways and that rutin may modulate a signaling crosstalk between JAK2 and MAPK.	Rutin	41-46	Janus kinase 2	Homo sapiens	202-206
19707521-1	2009	Three major flavonoid chamomile components (quercetin, apigenin-7-O-glucoside and rutin) were subjected to oxidative metabolism by cytochrome P-450 of rat liver microsomal preparations.	Rutin	82-87	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	131-147
19364325-3	2009	Peroxidase activity of the complex of cytochrome c with dioleyl cardiolipin estimated by chemiluminescence with luminol decreased by 50% with quercetin, taxifolin, rutin, Trolox, and ionol at concentrations 0.7, 0.7, 0.8, 3, and 10 microM, respectively.	Rutin	164-169	cytochrome c, somatic	Homo sapiens	38-50
19204829-3	2009	Transgenic tobacco plants overexpressing AtPAL2 showed two and five times increases of CGA and rutin levels than the wild-type (WT) plants, respectively.	Rutin	95-100	phenylalanine ammonia-lyase 2	Arabidopsis thaliana	41-47
19204829-4	2009	Overexpression of NtHQT further increases the accumulation of CGA in the AtPAL2 plants to about three times than that of the WT level, while silencing of NtHQT in AtPAL2 plants results in about 12 times increase in rutin level than that of the WT plants.	Rutin	215-220	shikimate O-hydroxycinnamoyltransferase-like	Nicotiana tabacum	18-23
19204829-4	2009	Overexpression of NtHQT further increases the accumulation of CGA in the AtPAL2 plants to about three times than that of the WT level, while silencing of NtHQT in AtPAL2 plants results in about 12 times increase in rutin level than that of the WT plants.	Rutin	215-220	shikimate O-hydroxycinnamoyltransferase-like	Nicotiana tabacum	154-159
19204829-4	2009	Overexpression of NtHQT further increases the accumulation of CGA in the AtPAL2 plants to about three times than that of the WT level, while silencing of NtHQT in AtPAL2 plants results in about 12 times increase in rutin level than that of the WT plants.	Rutin	215-220	phenylalanine ammonia-lyase 2	Arabidopsis thaliana	163-169
19271503-2	2008	The results showed that rutin had hardly effect on the serum protein conformation, but influenced the secondary structure of serum albumin (SA) molecule with the addition of rutin into BSA and HSA solution.	Rutin	24-29	albumin	Homo sapiens	185-188
19271503-2	2008	The results showed that rutin had hardly effect on the serum protein conformation, but influenced the secondary structure of serum albumin (SA) molecule with the addition of rutin into BSA and HSA solution.	Rutin	174-179	albumin	Homo sapiens	125-138
19271503-2	2008	The results showed that rutin had hardly effect on the serum protein conformation, but influenced the secondary structure of serum albumin (SA) molecule with the addition of rutin into BSA and HSA solution.	Rutin	174-179	albumin	Homo sapiens	185-188
19271503-3	2008	The alpha-helix structure of BSA and HSA was decreased and the beta-sheet was increased with the increase in rutin concentration.	Rutin	109-114	albumin	Homo sapiens	29-32
18958421-10	2008	Fisetin, myricetin, and rutin suppressed activation of NF-kappaB indicated by inhibition of nuclear translocation of NF-kappaB, NF-kappaB/DNA binding, and NF-kappaB-dependent gene reporter assay.	Rutin	24-29	nuclear factor kappa B subunit 1	Homo sapiens	55-64
18958421-10	2008	Fisetin, myricetin, and rutin suppressed activation of NF-kappaB indicated by inhibition of nuclear translocation of NF-kappaB, NF-kappaB/DNA binding, and NF-kappaB-dependent gene reporter assay.	Rutin	24-29	nuclear factor kappa B subunit 1	Homo sapiens	117-126
18958421-10	2008	Fisetin, myricetin, and rutin suppressed activation of NF-kappaB indicated by inhibition of nuclear translocation of NF-kappaB, NF-kappaB/DNA binding, and NF-kappaB-dependent gene reporter assay.	Rutin	24-29	nuclear factor kappa B subunit 1	Homo sapiens	117-126
18958421-10	2008	Fisetin, myricetin, and rutin suppressed activation of NF-kappaB indicated by inhibition of nuclear translocation of NF-kappaB, NF-kappaB/DNA binding, and NF-kappaB-dependent gene reporter assay.	Rutin	24-29	nuclear factor kappa B subunit 1	Homo sapiens	117-126
18628248-2	2008	Increases in the protein, messenger RNA and enzyme activity levels of matrix metalloproteinase (MMP)-9 were observed in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells, and these were blocked by QUE, but not by quercitrin or rutin.	Rutin	240-245	matrix metallopeptidase 9	Homo sapiens	70-102
18456009-3	2008	Two natural occurring polyphenolic compounds, representative of glycosylated and unglycosylated flavonoid structures, namely quercetin and rutin, were thereby tested as potential ligands of plasmin(ogen), a serine (pro)protease, whose role in tumor cell invasion and migration has been reported.	Rutin	139-144	plasminogen	Homo sapiens	190-197
18456009-4	2008	Quercetin showed a ten folds higher affinity with plasmin with respect to rutin in terms of equilibrium dissociation constant, both compounds acting as in vitro moderate reversible inhibitors; additionally, quercetin and rutin prevented plasmin-incubated BB1 cells from releasing E-cadherin fragment to a different extent, respectively.	Rutin	74-79	plasminogen	Homo sapiens	50-57
17880164-6	2007	o-Coumaric acid and rutin also inhibited the expression of PPARgamma, C/EBPalpha and leptin and then up-regulated expression of adiponectin at the protein level.	Rutin	20-25	leptin	Homo sapiens	85-91
18471079-4	2008	Human embryonic kidney (HEK) 293 cells stably expressing hSGLT1 (hSGLT1/HEK293 cells) display a Na(+)-dependent, phlorizin-sensitive alpha-methyl-D-[(14)C]glucopyranoside flux with expected kinetic parameters.	Rutin	155-170	solute carrier family 5 member 1	Homo sapiens	57-63
18471079-4	2008	Human embryonic kidney (HEK) 293 cells stably expressing hSGLT1 (hSGLT1/HEK293 cells) display a Na(+)-dependent, phlorizin-sensitive alpha-methyl-D-[(14)C]glucopyranoside flux with expected kinetic parameters.	Rutin	155-170	solute carrier family 5 member 1	Homo sapiens	65-71
18379051-4	2008	However, the effects of quercetin glycosides on glycine and 5-HT3A receptor channel activities are not well known.	Rutin	24-44	5-hydroxytryptamine receptor 3A	Homo sapiens	60-66
18379051-10	2008	These results also indicate that quercetin glycosides might regulate the human glycine alpha1 and mouse 5-HT3A receptors with differential manners.	Rutin	33-53	5-hydroxytryptamine receptor 3A	Homo sapiens	104-110
18946510-5	2008	Results of enzyme kinetics revealed that curcumin, compared to the polyphenols quercetin, myricetin, kaempferol, luteolin and rutin, elicited a stronger competitive inhibitory effect on Glo1 (K(i) = 5.1+/-1.4 microM).	Rutin	126-131	glyoxalase I	Homo sapiens	186-190
18254248-8	2007	These results indicate that quercetin and rutin may be useful in the treatment of IAR and LAR in asthma via inhibition of histamine release, PLA2, and EPO, and reduced recruitment of neutrophils and eosinophils into the lung.	Rutin	42-47	erythropoietin	Cavia porcellus	151-154
18305398-1	2008	Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages.	Rutin	0-5	TNF superfamily member 11	Homo sapiens	73-111
18305398-1	2008	Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages.	Rutin	0-5	TNF superfamily member 11	Homo sapiens	113-118
18252009-7	2008	RESULTS: RU inhibited inflammation-related gene expression in activated human macrophages and the release of nitric oxide, tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 from these cells.	Rutin	9-11	interleukin 1 alpha	Homo sapiens	152-170
18252009-7	2008	RESULTS: RU inhibited inflammation-related gene expression in activated human macrophages and the release of nitric oxide, tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 from these cells.	Rutin	9-11	interleukin 6	Homo sapiens	176-180
17549591-11	2008	Enhanced TNFalpha release was observed in astrocyte primary cultures treated with 100 micromol/L rutin and in mixed primary cultures treated with 50 and 100 micromol/L, suggesting different sensitivity of both activated cell types.	Rutin	97-102	tumor necrosis factor	Rattus norvegicus	9-17
17880164-6	2007	o-Coumaric acid and rutin also inhibited the expression of PPARgamma, C/EBPalpha and leptin and then up-regulated expression of adiponectin at the protein level.	Rutin	20-25	adiponectin, C1Q and collagen domain containing	Homo sapiens	128-139
17344335-9	2007	Inhibition studies demonstrated that CBR1 V88 and CBR1 I88 are distinctively inhibited by the flavonoid, rutin (IC50 CBR1 V88, 54.0 +/- 0.4 microM versus IC50 CBR1 I88, 15.0 +/- 0.1 microM, p &lt; 0.001).	Rutin	105-110	carbonyl reductase 1	Homo sapiens	37-41
17880164-6	2007	o-Coumaric acid and rutin also inhibited the expression of PPARgamma, C/EBPalpha and leptin and then up-regulated expression of adiponectin at the protein level.	Rutin	20-25	peroxisome proliferator activated receptor gamma	Homo sapiens	59-68
17880164-6	2007	o-Coumaric acid and rutin also inhibited the expression of PPARgamma, C/EBPalpha and leptin and then up-regulated expression of adiponectin at the protein level.	Rutin	20-25	CCAAT enhancer binding protein alpha	Homo sapiens	70-80
17666865-2	2007	Both rutin and quercetin (50 mg/kg x 2) improved spatial memory impairment in the 8-arm radial maze task and neuronal death in the hippocampal CA1 area; however, catechin (200 mg/kg x 2) and EGCG (50 mg/kg x 1) did not.	Rutin	5-10	carbonic anhydrase 1	Rattus norvegicus	143-146
17344335-9	2007	Inhibition studies demonstrated that CBR1 V88 and CBR1 I88 are distinctively inhibited by the flavonoid, rutin (IC50 CBR1 V88, 54.0 +/- 0.4 microM versus IC50 CBR1 I88, 15.0 +/- 0.1 microM, p &lt; 0.001).	Rutin	105-110	carbonyl reductase 1	Homo sapiens	50-54
17344335-9	2007	Inhibition studies demonstrated that CBR1 V88 and CBR1 I88 are distinctively inhibited by the flavonoid, rutin (IC50 CBR1 V88, 54.0 +/- 0.4 microM versus IC50 CBR1 I88, 15.0 +/- 0.1 microM, p &lt; 0.001).	Rutin	105-110	carbonyl reductase 1	Homo sapiens	50-54
17344335-9	2007	Inhibition studies demonstrated that CBR1 V88 and CBR1 I88 are distinctively inhibited by the flavonoid, rutin (IC50 CBR1 V88, 54.0 +/- 0.4 microM versus IC50 CBR1 I88, 15.0 +/- 0.1 microM, p &lt; 0.001).	Rutin	105-110	carbonyl reductase 1	Homo sapiens	50-54
17519113-6	2007	It was found that pretreatment with rutin- iron complex protected against thioacetamide induced hepatotoxicity as observed by a significant reduction in the elevated levels of serum enzymes and partial normalization of GSH/GSSG ratio, glutathione peroxidase II and glutathione reductase activity in mice liver.	Rutin	36-41	glutathione reductase	Mus musculus	265-286
17141727-3	2007	The flavonols rutin, quercetin, myricetin, and kaempferol inhibited the inactivation of alpha1-antitrypsin by HOCl and HOBr with rutin having the most pronounced effect.	Rutin	14-19	serpin family A member 1	Homo sapiens	88-106
17141727-3	2007	The flavonols rutin, quercetin, myricetin, and kaempferol inhibited the inactivation of alpha1-antitrypsin by HOCl and HOBr with rutin having the most pronounced effect.	Rutin	129-134	serpin family A member 1	Homo sapiens	88-106
17477412-4	2007	In addition, we observed an increase in the iNOS expression in I/R group compared with control and rutin administration attenuated this increase; in post-ischemic reperfused rutin-treated rats there was a significant increase in eNOS expression compared with the I/R untreated group.	Rutin	99-104	nitric oxide synthase 2	Rattus norvegicus	44-48
18447002-1	2007	The effect of rutin, a flavonoid present in onions, apples, tea and red wine, on the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) was analyzed using in vitro as well as in vivo systems.	Rutin	14-19	tumor necrosis factor	Mus musculus	150-159
18447002-4	2007	The drastically elevated levels of TNF-alpha in LPS stimulated animals (686.8 pg/ml) was lowered by pretreatment with rutin (182.4 pg/ml).	Rutin	118-123	tumor necrosis factor	Mus musculus	35-44
17849271-9	2007	Spleen cells cultured with LPS and rutin showed a decrease on apoptosis after 24 hr and an increase on the IL-10 levels after 48 hr.	Rutin	35-40	interleukin 10	Rattus norvegicus	107-112
17477412-4	2007	In addition, we observed an increase in the iNOS expression in I/R group compared with control and rutin administration attenuated this increase; in post-ischemic reperfused rutin-treated rats there was a significant increase in eNOS expression compared with the I/R untreated group.	Rutin	174-179	nitric oxide synthase 2	Rattus norvegicus	44-48
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	Rutin	129-134	linoleate 9S-lipoxygenase-4	Glycine max	138-150
17151464-4	2006	Quercetin glycosides and kaempherol glycosides were identified in MFH, of which quercetin glycosides contributed to the inhibition of histamine release.	Rutin	0-20	forkhead box P1	Homo sapiens	66-69
17151464-4	2006	Quercetin glycosides and kaempherol glycosides were identified in MFH, of which quercetin glycosides contributed to the inhibition of histamine release.	Rutin	80-100	forkhead box P1	Homo sapiens	66-69
16616263-10	2006	In contrast mutants defective in light perception such as the high pigment (hp-1) and LA3771 possess elevated chlorogenic acid and rutin as well as increased carotenoid content.	Rutin	131-136	DNA damage-binding protein 1	Solanum lycopersicum	76-80
16815818-3	2006	Green tea polyphenol, epigallocatechin gallate, quercetin, and rutin can reduce the co-oxidation reaction speed of tested compounds mediated by soybean lipoxygenase and the production of oxidative products and free radical intermediates.	Rutin	63-68	linoleate 9S-lipoxygenase-4	Glycine max	152-164
16451754-4	2006	The glycosides rutin and quercitrin gave dose-dependent increases in GST activity, with a 50% and 24.5% increase at 250 mM, respectively, while the aglycone quercetin inhibited the enzyme by 30% at 250 mM.	Rutin	15-20	glutathione S-transferase kappa 1	Homo sapiens	69-72
16596994-2	2006	The present study showed that dietary antioxidants such as (-)-epigallocatechin gallate, quercerin, rutin, resveratrol, and ursolic acid inhibit single strand breaks in supercoiled plasmid DNA induced by 3-morpholinosydnomine N-ethylcarbamide (SIN-1), a generator of peroxynitrite through the reaction between nitric oxide and superoxide anion.	Rutin	100-105	MAPK associated protein 1	Homo sapiens	244-249
16551686-9	2006	Analysis of the soluble phenolic fraction by HPLC-MS revealed that vegetative organs of CCR down-regulated plants contained higher amounts of chlorogenic acid and rutin, and accumulated new metabolites undetectable in the wild type, such as N-caffeoyl putrescine and kaempferol rutinoside.	Rutin	163-168	cinnamoyl-CoA reductase	Solanum lycopersicum	88-91
16271822-3	2006	While seven flavonoids (myricetin, apigenin, kaempferol, quercetin, amentoflavone, quercitrin and rutin) were slightly more selective for CYP 1B1 EROD inhibition (K(i)s 0.06-5.96 microM) compared to CYP 1A1 (K(i)s 0.20-1.6 microM) the difference in K(i)s for the P450s were not significantly different.	Rutin	98-103	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	138-145
16271822-3	2006	While seven flavonoids (myricetin, apigenin, kaempferol, quercetin, amentoflavone, quercitrin and rutin) were slightly more selective for CYP 1B1 EROD inhibition (K(i)s 0.06-5.96 microM) compared to CYP 1A1 (K(i)s 0.20-1.6 microM) the difference in K(i)s for the P450s were not significantly different.	Rutin	98-103	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	199-206
16433898-6	2006	Oral administration of rutin to diabetic rats significantly (P&lt;0.05) decreased fasting plasma glucose, glycosylated haemoglobin and increased insulin, C-peptide, haemoglobin and protein levels.	Rutin	23-28	insulin 2	Rattus norvegicus	154-163
17119273-4	2006	Activity of glycerol-3-phosphate dehydrogenase (GPDH), which has a central position in lipogenesis in adipose cells, was also decreased by rutin addition at the induction stage.	Rutin	139-144	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	12-46
17119273-4	2006	Activity of glycerol-3-phosphate dehydrogenase (GPDH), which has a central position in lipogenesis in adipose cells, was also decreased by rutin addition at the induction stage.	Rutin	139-144	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	48-52
15911222-6	2005	However, the investigated flavonoids did show potency to inhibit OCT-mediated transport (IC50-values: quercetin&lt;kaempferol&lt;&lt;naringenin&lt;isoquercitrin&lt;spiraeoside&lt;&lt;rutin&lt;hesperetin&lt;naringin).	Rutin	183-188	plexin A2	Homo sapiens	65-68
16132362-10	2005	CONCLUSIONS: Our data suggest that rutin acted as a quercetin deliverer to the large intestine and its anti-inflammatory action in TNBS-induced colitis rats may be through quercetin-mediated inhibition of TNF-alpha-induced NFkappaB activation.	Rutin	35-40	tumor necrosis factor	Rattus norvegicus	205-214
16132362-10	2005	CONCLUSIONS: Our data suggest that rutin acted as a quercetin deliverer to the large intestine and its anti-inflammatory action in TNBS-induced colitis rats may be through quercetin-mediated inhibition of TNF-alpha-induced NFkappaB activation.	Rutin	35-40	nuclear factor kappa B subunit 1	Homo sapiens	223-231
15877109-14	2005	However, myocardial fructose levels were significantly decreased in the rutin- and quercetin-treated animals compared with the vehicle-treated animals, possibly owing to their aldose reductase inhibitory activity.	Rutin	72-77	aldo-keto reductase family 1 member B1	Rattus norvegicus	176-192
15877109-16	2005	Results from the present investigation demonstrated that rutin has a cardioprotective activity, and we conclude that the observed cardioprotection with rutin may be due to its aldose reductase inhibitory activity, as the enhanced aldose reductase pathway is implicated in the development of left ventricle dysfunction by several studies.	Rutin	57-62	aldo-keto reductase family 1 member B1	Rattus norvegicus	230-246
15877109-16	2005	Results from the present investigation demonstrated that rutin has a cardioprotective activity, and we conclude that the observed cardioprotection with rutin may be due to its aldose reductase inhibitory activity, as the enhanced aldose reductase pathway is implicated in the development of left ventricle dysfunction by several studies.	Rutin	152-157	aldo-keto reductase family 1 member B1	Rattus norvegicus	176-192
15877109-16	2005	Results from the present investigation demonstrated that rutin has a cardioprotective activity, and we conclude that the observed cardioprotection with rutin may be due to its aldose reductase inhibitory activity, as the enhanced aldose reductase pathway is implicated in the development of left ventricle dysfunction by several studies.	Rutin	152-157	aldo-keto reductase family 1 member B1	Rattus norvegicus	230-246
15652231-8	2005	Further, DSS-induced increases in colonic mucosal IL-1 beta levels were blunted significantly in rutin-, but not quercetin-, fed mice (P&lt;0.01), while dietary rutin attenuated the expressions of IL-1 beta and IL-6 mRNA in colonic mucosa (each, P&lt;0.01).	Rutin	97-102	interleukin 1 beta	Mus musculus	50-59
15664304-6	2005	The extract, rutin and quercetin caused concentration-dependent inhibition of soybean Lox activity.	Rutin	13-18	linoleate 9S-lipoxygenase-4	Glycine max	86-89
15664304-7	2005	These results indicate that rutin, quercetin and an extract of C. arabica containing these compounds inhibit Lox activity, consequently decreasing LTB4 production.	Rutin	28-33	linoleate 9S-lipoxygenase-4	Glycine max	109-112
16128280-10	2005	The results of our study showed: 1) the decrease in PMN oxidant production in patient during the mass reduction, 2) the strong antioxidant activity of quercetin and rutin in obese patients before and during the body mass reduction, these effects were dose dependent and rutin was less potent than quercetin, 3) acceleration of PMN apoptosis by rutin is associated with an increase in caspase 3 activity.	Rutin	165-170	caspase 3	Homo sapiens	384-393
15652231-10	2005	Notably, a 0.1% rutin diet given 3 days after DSS treatment significantly suppressed both colorectal shortening and IL-1 beta production (P&lt;0.05 and &lt;0.01, respectively).	Rutin	16-21	interleukin 1 beta	Mus musculus	116-125
15450951-3	2004	The MMC-induced cell death and decrease in the GSH contents in SCLC cells were inhibited by caspase inhibitors (z-DQMD.fmk, z-IETD.fmk and z-LEHD.fmk) and antioxidants (N-acetylcysteine, dithiothreitol and N-(2-mercaptopropionyl)glycine, melatonin, rutin and carboxy-PTIO).	Rutin	249-254	caspase 8	Homo sapiens	92-99
15631523-1	2005	The interaction between four flavonoids (catechin, epicatechin, rutin, and quercetin) and bovine serum albumin (BSA) was investigated using tryptophan fluorescence quenching.	Rutin	64-69	albumin	Homo sapiens	97-116
14979715-9	2004	Despite being largely structurally different from PGD(2), rutin is located at the same site of PGD(2), and its catechol and rhamnose moieties are involved in hydrogen bonds with PGFS.	Rutin	58-63	aldo-keto reductase family 1 member C3	Homo sapiens	178-182
15450951-4	2004	Thiol compounds, melatonin and rutin attenuated the MMC-induced nuclear damage, decrease in mitochondrial transmembrane potential, release of cytochrome c and activation of caspase-3.	Rutin	31-36	cytochrome c, somatic	Homo sapiens	142-154
15450951-4	2004	Thiol compounds, melatonin and rutin attenuated the MMC-induced nuclear damage, decrease in mitochondrial transmembrane potential, release of cytochrome c and activation of caspase-3.	Rutin	31-36	caspase 3	Homo sapiens	173-182
15182918-5	2004	In addition, Biota orientalis extract, quercetin and rutin, when tested in vivo on mouse liver homogenates, elicited significant inhibitory actions on the xanthine dehydrogenase/xanthine oxidase (XDH/XO) activities.	Rutin	53-58	xanthine dehydrogenase	Mus musculus	155-177
15182918-5	2004	In addition, Biota orientalis extract, quercetin and rutin, when tested in vivo on mouse liver homogenates, elicited significant inhibitory actions on the xanthine dehydrogenase/xanthine oxidase (XDH/XO) activities.	Rutin	53-58	xanthine dehydrogenase	Mus musculus	178-194
14981311-3	2004	Several compounds, including alpha-tocopherol, gallic acid, (-)-catechin and rutin, were found to be highly effective for attenuating IL-1beta production, suggesting that they would be useful for anti-inflammatory application.	Rutin	77-82	interleukin 1 beta	Mus musculus	134-142
14974735-6	2003	OPN was comparable to polyphenols such as (+)-catechin, rutin and gallic acid in the antioxidative activity against linoleic acid peroxidation, and was an effective DPPH radical scavenger, though the DPPH radical-scavenging activity of OPN was somewhat lower than that of the polyphenols.	Rutin	56-61	secreted phosphoprotein 1	Homo sapiens	0-3
14710438-5	2003	Rutin, a phospholipase A2 inhibitor, and N omega-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, also attenuated the contraction induced by endotoxin.	Rutin	0-5	phospholipase A2 group IB	Rattus norvegicus	9-25
12423426-5	2002	Treatments of oesophagitis rats with rutin and harmaline inhibited lipid peroxidation, and myeloperoxidase (MPO) in the oesophagus in comparison with untreated rats.	Rutin	37-42	myeloperoxidase	Rattus norvegicus	91-106
12350136-5	2002	Treatment with a higher concentration of rutin significantly decreased catalase activity and iron, zinc, and copper contents in mouse liver; it also resulted in a slower weight gain for the first 20 d. These results indicate that rutin taken in proper amount can effectively improve antioxidant status, whereas at an increased dosage, it may cause trace element (such as iron, zinc, and copper) deficiencies and a decrease in the activities of related metal-containing enzymes.	Rutin	41-46	catalase	Mus musculus	71-79
12350136-5	2002	Treatment with a higher concentration of rutin significantly decreased catalase activity and iron, zinc, and copper contents in mouse liver; it also resulted in a slower weight gain for the first 20 d. These results indicate that rutin taken in proper amount can effectively improve antioxidant status, whereas at an increased dosage, it may cause trace element (such as iron, zinc, and copper) deficiencies and a decrease in the activities of related metal-containing enzymes.	Rutin	230-235	catalase	Mus musculus	71-79
12098601-9	2002	A decrease in iNOS protein, but not cyclooxygenase-2 protein, was detected in liver and lung specimens of lipopolysaccharide-treated Balb/c mice in the presence of rutin, wogonin or quercetin.	Rutin	164-169	nitric oxide synthase 2, inducible	Mus musculus	14-18
12840208-1	2003	We examined the ability of polyphenols from tomatoes and soy (genistein, quercetin, kaempferol, biochanin A, daidzein and rutin) to modulate insulin-like growth factor-I (IGF-I)-induced in vitro proliferation and apoptotic resistance in the AT6.3 rat prostate cancer cell line.	Rutin	122-127	insulin-like growth factor 1	Rattus norvegicus	141-169
12606047-2	2003	The oxidation of LDL was inhibited by micromolar concentrations of flavonoids such as (-)-epicatechin, quercetin, rutin, taxifolin and luteolin, presumably via scavenging of the MPO-derived NO(2) radical.	Rutin	114-119	myeloperoxidase	Homo sapiens	178-181
12490212-0	2002	Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents.	Rutin	21-26	C-C motif chemokine ligand 4	Rattus norvegicus	47-51
12206678-8	2002	In contrast, rutin, a related flavonoid which does not bind to LDL, cannot repair oxidized apolipoprotein B.	Rutin	13-18	apolipoprotein B	Homo sapiens	91-107
12423426-5	2002	Treatments of oesophagitis rats with rutin and harmaline inhibited lipid peroxidation, and myeloperoxidase (MPO) in the oesophagus in comparison with untreated rats.	Rutin	37-42	myeloperoxidase	Rattus norvegicus	108-111
12423426-9	2002	Treatments of oesophagitis rats with rutin and harmaline inhibited IL-1beta production in the oesophagus in comparison with untreated rats, but TNF-alpha production was not affected by rutin and harmaline.	Rutin	37-42	interleukin 1 beta	Rattus norvegicus	67-75
12423426-12	2002	The results of this study suggest that rutin and harmaline may have beneficial protective effects against reflux oesophagitis by the inhibition of gastric acid secretion, oxidative stress, inflammatory cytokine production (i.e. IL-1beta), and intracellular calcium mobilization in PMNs in rats.	Rutin	39-44	interleukin 1 beta	Rattus norvegicus	228-236
11500931-0	2001	Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages.	Rutin	133-138	prostaglandin-endoperoxide synthase 2	Mus musculus	96-112
11697193-4	2001	Also, .UH- is reduced by flavonoids, quercetin and rutin in CTAB micelles at rate constants of 6 x 10(6) M-1s-1 and 1 x 10(6) M-1s-1, respectively.	Rutin	51-56	tumor associated calcium signal transducer 2	Homo sapiens	105-132
8792656-1	1996	3,4-Dihydroxyphenylacetic acid, 3-hydroxyphenylacetic acid, and 3-(4-hydroxyphenyl)-propionic acid, metabolites which arise from quercetin glycosides, respectively, from flavones and probably from procyanidins by the human intestinal microflora, have been tested for their effects on oxygen radical production by human PMNs stimulated with FMLP or opsonized zymosan.	Rutin	129-149	formyl peptide receptor 1	Homo sapiens	340-344
10964096-6	2000	Positive cyclin D(1) expression was detected in mice on diets supplemented either with quercetin (P: &lt; 0.01) or rutin (P: &lt; 0.05).	Rutin	115-120	cyclin D1	Mus musculus	9-20
8968052-0	1996	Dietary quercetin glycosides: antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells.	Rutin	8-28	crystallin, zeta	Mus musculus	112-129
9246576-4	1997	Rutin also efficiently inhibited human PLA2-II from synovial fluid but was only a weak inhibitor of human PLA2-I from pancreatic juice, suggesting that rutin is a selective PLA2-I from porcine pancreas.	Rutin	0-5	phospholipase A2 group IIA	Homo sapiens	39-43
9246576-4	1997	Rutin also efficiently inhibited human PLA2-II from synovial fluid but was only a weak inhibitor of human PLA2-I from pancreatic juice, suggesting that rutin is a selective PLA2-I from porcine pancreas.	Rutin	0-5	phospholipase A2 group IIA	Homo sapiens	106-110
9246576-4	1997	Rutin also efficiently inhibited human PLA2-II from synovial fluid but was only a weak inhibitor of human PLA2-I from pancreatic juice, suggesting that rutin is a selective PLA2-I from porcine pancreas.	Rutin	0-5	phospholipase A2 group IIA	Homo sapiens	106-110
8523269-4	1995	Some selected flavonoids such as naringin, apiin, poncirin and rutin were shown to amplify TNF release from murine macrophages in vivo in response to OK-432 as a second stimulus.	Rutin	63-68	tumor necrosis factor	Mus musculus	91-94
8934767-2	1996	In order to protect fibrinogen during UVC irradiation, 0.5 mM rutin was added prior to UVC exposure and subsequently removed during processing.	Rutin	62-67	fibrinogen beta chain	Homo sapiens	20-30
8934767-7	1996	Experiments with 3H-rutin showed that after UVC irradiation, subsequent processing by a C18 resin and alcohol precipitation removed &gt; 99% rutin, representing &lt; 10 ppm rutin in the final fibrinogen preparations.	Rutin	141-146	fibrinogen beta chain	Homo sapiens	192-202
8967509-3	1996	The augmented group II PLA2 mRNA levels corresponded to a rise in membrane-associated PLA2 enzymatic activity that was inhibited by rutin, an inhibitor of group II PLA2.	Rutin	132-137	phospholipase A2 group IB	Rattus norvegicus	23-27
8967509-3	1996	The augmented group II PLA2 mRNA levels corresponded to a rise in membrane-associated PLA2 enzymatic activity that was inhibited by rutin, an inhibitor of group II PLA2.	Rutin	132-137	phospholipase A2 group IB	Rattus norvegicus	86-90
8967509-3	1996	The augmented group II PLA2 mRNA levels corresponded to a rise in membrane-associated PLA2 enzymatic activity that was inhibited by rutin, an inhibitor of group II PLA2.	Rutin	132-137	phospholipase A2 group IB	Rattus norvegicus	86-90