PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35163434-0	2022	Kinome-Wide Profiling Identifies Human WNK3 as a Target of Cajanin Stilbene Acid from Cajanus cajan (L.) Millsp.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	59-80	WNK lysine deficient protein kinase 3	Homo sapiens	39-43
35163434-5	2022	The serine-threonine kinase WNK3 (also known as protein kinase lysine-deficient 3) was identified as the most promising target of CSA with the strongest enzymatic activity inhibition in vitro and the highest binding affinity in molecular docking in silico.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	130-133	WNK lysine deficient protein kinase 3	Homo sapiens	28-32
31837410-7	2020	CSA also reversed the CUMS-induced decrease in the levels of BDNF, PSD-95, p-Akt/Akt and p-mTOR/mTOR.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	brain derived neurotrophic factor	Mus musculus	61-65
33560125-6	2021	Four new CSA metabolites were found in vivo, namely, CSA-2-COO-glucuronide, 6,12-dihydroxy CSA, 3-hydroxy-5-methoxystilbene-3-O-glucuronide, and 6-hydroxy CSA-3-O-glucuronide, in addition to our previously reported metabolite CSA-3-O-glucuronide.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	9-12	IK cytokine	Homo sapiens	53-58
31837410-7	2020	CSA also reversed the CUMS-induced decrease in the levels of BDNF, PSD-95, p-Akt/Akt and p-mTOR/mTOR.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	discs large MAGUK scaffold protein 4	Mus musculus	67-73
31837410-7	2020	CSA also reversed the CUMS-induced decrease in the levels of BDNF, PSD-95, p-Akt/Akt and p-mTOR/mTOR.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	thymoma viral proto-oncogene 1	Mus musculus	77-80
31837410-7	2020	CSA also reversed the CUMS-induced decrease in the levels of BDNF, PSD-95, p-Akt/Akt and p-mTOR/mTOR.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	thymoma viral proto-oncogene 1	Mus musculus	81-84
31837410-7	2020	CSA also reversed the CUMS-induced decrease in the levels of BDNF, PSD-95, p-Akt/Akt and p-mTOR/mTOR.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	mechanistic target of rapamycin kinase	Mus musculus	91-95
31837410-7	2020	CSA also reversed the CUMS-induced decrease in the levels of BDNF, PSD-95, p-Akt/Akt and p-mTOR/mTOR.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	mechanistic target of rapamycin kinase	Mus musculus	96-100
31837410-8	2020	Therefore, the antidepressant-like effects of CSA might be achieved through regulating tryptophan metabolism, promoting BDNF and PSD-95 expression, and activating Akt/mTOR pathway in the cerebral cortex.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	46-49	brain derived neurotrophic factor	Mus musculus	120-124
31837410-8	2020	Therefore, the antidepressant-like effects of CSA might be achieved through regulating tryptophan metabolism, promoting BDNF and PSD-95 expression, and activating Akt/mTOR pathway in the cerebral cortex.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	46-49	discs large MAGUK scaffold protein 4	Mus musculus	129-135
31837410-8	2020	Therefore, the antidepressant-like effects of CSA might be achieved through regulating tryptophan metabolism, promoting BDNF and PSD-95 expression, and activating Akt/mTOR pathway in the cerebral cortex.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	46-49	thymoma viral proto-oncogene 1	Mus musculus	163-166
31837410-8	2020	Therefore, the antidepressant-like effects of CSA might be achieved through regulating tryptophan metabolism, promoting BDNF and PSD-95 expression, and activating Akt/mTOR pathway in the cerebral cortex.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	46-49	mechanistic target of rapamycin kinase	Mus musculus	167-171
31680939-7	2019	In addition, CSA inhibited excessive expression of GluN2B-containing NMDARs and upregulated the downstream PKA/CREB/BDNF/TrkB signaling pathway.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	13-16	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	51-57
23535287-0	2013	Cajaninstilbene acid (CSA) exerts cytoprotective effects against oxidative stress through the Nrf2-dependent antioxidant pathway.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-20	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
31680939-7	2019	In addition, CSA inhibited excessive expression of GluN2B-containing NMDARs and upregulated the downstream PKA/CREB/BDNF/TrkB signaling pathway.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	13-16	cAMP responsive element binding protein 1	Mus musculus	111-115
31680939-7	2019	In addition, CSA inhibited excessive expression of GluN2B-containing NMDARs and upregulated the downstream PKA/CREB/BDNF/TrkB signaling pathway.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	13-16	brain derived neurotrophic factor	Mus musculus	116-120
31680939-7	2019	In addition, CSA inhibited excessive expression of GluN2B-containing NMDARs and upregulated the downstream PKA/CREB/BDNF/TrkB signaling pathway.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	13-16	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	121-125
30515822-0	2019	Cajaninstilbene acid inhibits osteoporosis through suppressing osteoclast formation and RANKL-induced signaling pathways.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-20	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	88-93
30515822-4	2019	We observed that CSA has the ability to suppress RANKL-mediated osteoclastogenesis, osteoclast marker gene expression, and bone resorption in a dose-dependent manner.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	17-20	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	49-54
30515822-5	2019	Mechanistically, it was revealed that CSA attenuates RANKL-activated NF-kappaB and nuclear factor of activated T-cell pathways and inhibited phosphorylation of key signaling mediators c-Fos, V-ATPase-d2, and ERK.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	38-41	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	53-58
30515822-5	2019	Mechanistically, it was revealed that CSA attenuates RANKL-activated NF-kappaB and nuclear factor of activated T-cell pathways and inhibited phosphorylation of key signaling mediators c-Fos, V-ATPase-d2, and ERK.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	38-41	FBJ osteosarcoma oncogene	Mus musculus	184-189
30515822-5	2019	Mechanistically, it was revealed that CSA attenuates RANKL-activated NF-kappaB and nuclear factor of activated T-cell pathways and inhibited phosphorylation of key signaling mediators c-Fos, V-ATPase-d2, and ERK.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	38-41	mitogen-activated protein kinase 1	Mus musculus	208-211
30515822-6	2019	Moreover, in osteoclasts, CSA blocked RANKL-induced ROS activity as well as calcium oscillations.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	26-29	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	38-43
30704067-8	2019	Finally, we identified the cajaninstilbene acid, a main bioactive stilbene component in MECC, which significantly modulated the LDLR and PCSK9 expression in HepG2 cells.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	27-47	low density lipoprotein receptor	Homo sapiens	128-132
30704067-8	2019	Finally, we identified the cajaninstilbene acid, a main bioactive stilbene component in MECC, which significantly modulated the LDLR and PCSK9 expression in HepG2 cells.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	27-47	proprotein convertase subtilisin/kexin type 9	Homo sapiens	137-142
26998619-2	2016	In this study, anti-inflammatory effects of CSA and its synthesized derivatives were fully valued with regard to their activities on the production of nitric oxide (NO) and pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in vitro cell model, as well as their impacts on the migration of neutrophils and macrophages in fluorescent protein labeled zebrafish larvae model by live image analysis.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	44-47	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	200-227
26998619-2	2016	In this study, anti-inflammatory effects of CSA and its synthesized derivatives were fully valued with regard to their activities on the production of nitric oxide (NO) and pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in vitro cell model, as well as their impacts on the migration of neutrophils and macrophages in fluorescent protein labeled zebrafish larvae model by live image analysis.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	44-47	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	229-238
26998619-2	2016	In this study, anti-inflammatory effects of CSA and its synthesized derivatives were fully valued with regard to their activities on the production of nitric oxide (NO) and pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in vitro cell model, as well as their impacts on the migration of neutrophils and macrophages in fluorescent protein labeled zebrafish larvae model by live image analysis.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	44-47	interleukin 6 (interferon, beta 2)	Danio rerio	244-257
26998619-2	2016	In this study, anti-inflammatory effects of CSA and its synthesized derivatives were fully valued with regard to their activities on the production of nitric oxide (NO) and pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in vitro cell model, as well as their impacts on the migration of neutrophils and macrophages in fluorescent protein labeled zebrafish larvae model by live image analysis.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	44-47	interleukin 6 (interferon, beta 2)	Danio rerio	259-263
26998619-4	2016	The results showed that CSA, as well as its synthesized derivatives 5c, 5e and 5h, exhibited strong inhibition activity on the release of NO and inflammatory factor TNF-alpha and IL-6 in lipopolysaccharides (LPS)-stimulated murine macrophages.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	24-27	tumor necrosis factor	Mus musculus	165-174
26998619-4	2016	The results showed that CSA, as well as its synthesized derivatives 5c, 5e and 5h, exhibited strong inhibition activity on the release of NO and inflammatory factor TNF-alpha and IL-6 in lipopolysaccharides (LPS)-stimulated murine macrophages.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	24-27	interleukin 6	Mus musculus	179-183
26998619-9	2016	Additionally, the mechanism studies demonstrated that the anti-inflammatory activity of CSA and its derivative is associated with the inhibition of NF-kappaB and MAPK pathways, relying partly on resisting the LPS-induced decrease of PPARgamma through improving its expression.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	88-91	peroxisome proliferator-activated receptor gamma	Danio rerio	233-242
25716159-6	2016	Molecular docking on MYC/MAX complex and reporter cell line experiments were performed to validate the MYC inhibitory activity of CSA and its derivatives.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	130-133	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	21-24
25716159-6	2016	Molecular docking on MYC/MAX complex and reporter cell line experiments were performed to validate the MYC inhibitory activity of CSA and its derivatives.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	130-133	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	103-106
25716159-11	2016	Luciferase-based reporter cell line experiments and molecular docking studies yielded supportive results emphasizing the inhibitory activity of CSA and its derivatives on MYC.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	144-147	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	171-174
26365581-4	2015	We analyzed the cytotoxic and anticancer activity of CSA in ERalpha-positive and -negative human breast cancer cells in vitro, in vivo and in silico.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	53-56	estrogen receptor 1	Homo sapiens	60-67
26365581-5	2015	CSA exerts anticancer and antiestrogenic activities towards ERalpha-positive breast cancer, and it showed cytotoxicity towards tamoxifen-resistant MCF-7 cells, implying that CSA may be active against tamoxifen-resistant breast cancer cells.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	estrogen receptor 1	Homo sapiens	60-67
26365581-6	2015	CSA showed low cytotoxicity in ERalpha-negative breast tumor cells as expected.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	estrogen receptor 1	Homo sapiens	31-38
26365581-7	2015	Comparable cytotoxicity was observed towards p53 negative MCF-7 cells, implying that CSA is effective independent of the p53 status.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	85-88	tumor protein p53	Homo sapiens	45-48
26365581-10	2015	Dose-dependent decrease in ERalpha protein levels was observed upon CSA treatment.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	68-71	estrogen receptor 1	Homo sapiens	27-34
26365581-12	2015	CSA affected pathways related to p53, cancer and cell proliferation.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	tumor protein p53	Homo sapiens	33-36
26365581-14	2015	CSA bound to the same site as 17beta-estradiol and tamoxifen on ERalpha.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	estrogen receptor 1	Homo sapiens	64-71
26365581-15	2015	In conclusion, CSA exerts its anticancer effects in ERalpha-positive breast cancer cells by binding and inhibiting ERalpha.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	15-18	estrogen receptor 1	Homo sapiens	52-59
26365581-15	2015	In conclusion, CSA exerts its anticancer effects in ERalpha-positive breast cancer cells by binding and inhibiting ERalpha.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	15-18	estrogen receptor 1	Homo sapiens	115-122
25272989-4	2014	The reaction phenotype study showed that CYP3A4, CYP2C9, and CYP1A2 were the major cytochrome P450 isozymes in the metabolism of CSA.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	129-132	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-47
25272989-4	2014	The reaction phenotype study showed that CYP3A4, CYP2C9, and CYP1A2 were the major cytochrome P450 isozymes in the metabolism of CSA.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	129-132	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	49-55
25272989-4	2014	The reaction phenotype study showed that CYP3A4, CYP2C9, and CYP1A2 were the major cytochrome P450 isozymes in the metabolism of CSA.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	129-132	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	61-67
25272989-8	2014	CSA reversibly inhibited CYP3A4 and CYP2C9 activities in human liver microsomes with IC50 values of 28.3 and 31.3 muM, respectively, but exhibited no inhibition activities to CYP1A2, CYP2A6, CYP2C19, CYP2D6, and CYP2E1.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	25-31
25272989-8	2014	CSA reversibly inhibited CYP3A4 and CYP2C9 activities in human liver microsomes with IC50 values of 28.3 and 31.3 muM, respectively, but exhibited no inhibition activities to CYP1A2, CYP2A6, CYP2C19, CYP2D6, and CYP2E1.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	36-42
25272989-8	2014	CSA reversibly inhibited CYP3A4 and CYP2C9 activities in human liver microsomes with IC50 values of 28.3 and 31.3 muM, respectively, but exhibited no inhibition activities to CYP1A2, CYP2A6, CYP2C19, CYP2D6, and CYP2E1.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	183-189
25272989-8	2014	CSA reversibly inhibited CYP3A4 and CYP2C9 activities in human liver microsomes with IC50 values of 28.3 and 31.3 muM, respectively, but exhibited no inhibition activities to CYP1A2, CYP2A6, CYP2C19, CYP2D6, and CYP2E1.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	191-198
25272989-8	2014	CSA reversibly inhibited CYP3A4 and CYP2C9 activities in human liver microsomes with IC50 values of 28.3 and 31.3 muM, respectively, but exhibited no inhibition activities to CYP1A2, CYP2A6, CYP2C19, CYP2D6, and CYP2E1.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	200-206
25272989-8	2014	CSA reversibly inhibited CYP3A4 and CYP2C9 activities in human liver microsomes with IC50 values of 28.3 and 31.3 muM, respectively, but exhibited no inhibition activities to CYP1A2, CYP2A6, CYP2C19, CYP2D6, and CYP2E1.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	212-218
23535287-0	2013	Cajaninstilbene acid (CSA) exerts cytoprotective effects against oxidative stress through the Nrf2-dependent antioxidant pathway.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	22-25	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
23535287-3	2013	This study examined the role of Nrf2 in CSA-mediated antioxidant effects on human hepatocarcinoma (HepG2) cell line.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	40-43	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
23535287-5	2013	CSA activated Nrf2 as evaluated by Western blotting.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
23535287-6	2013	A luciferase reporter assay also demonstrated that CSA-activated signaling resulted in the increased transcriptional activity of Nrf2 through binding to the antioxidant response element (ARE) enhancer sequence.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	51-54	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
23535287-7	2013	Our study indicated that treatment of HepG2 cells with CSA induces Nrf2-dependent ARE activity and gene expression of heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase modifier subunits by activation of PI3K/AKT, ERK and JNK signaling pathways.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	55-58	NFE2 like bZIP transcription factor 2	Homo sapiens	67-71
23535287-7	2013	Our study indicated that treatment of HepG2 cells with CSA induces Nrf2-dependent ARE activity and gene expression of heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase modifier subunits by activation of PI3K/AKT, ERK and JNK signaling pathways.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	55-58	heme oxygenase 1	Homo sapiens	118-134
23535287-7	2013	Our study indicated that treatment of HepG2 cells with CSA induces Nrf2-dependent ARE activity and gene expression of heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase modifier subunits by activation of PI3K/AKT, ERK and JNK signaling pathways.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	55-58	NAD(P)H quinone dehydrogenase 1	Homo sapiens	143-175
23535287-7	2013	Our study indicated that treatment of HepG2 cells with CSA induces Nrf2-dependent ARE activity and gene expression of heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase modifier subunits by activation of PI3K/AKT, ERK and JNK signaling pathways.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	55-58	NAD(P)H quinone dehydrogenase 1	Homo sapiens	177-181
23535287-7	2013	Our study indicated that treatment of HepG2 cells with CSA induces Nrf2-dependent ARE activity and gene expression of heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase modifier subunits by activation of PI3K/AKT, ERK and JNK signaling pathways.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	55-58	AKT serine/threonine kinase 1	Homo sapiens	254-257
23535287-7	2013	Our study indicated that treatment of HepG2 cells with CSA induces Nrf2-dependent ARE activity and gene expression of heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase modifier subunits by activation of PI3K/AKT, ERK and JNK signaling pathways.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	55-58	mitogen-activated protein kinase 1	Homo sapiens	259-262
23535287-8	2013	Inhibition of Nrf2 by siRNA reduced CSA-induced upregulation of these Nrf2-related enzymes.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	36-39	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
23535287-8	2013	Inhibition of Nrf2 by siRNA reduced CSA-induced upregulation of these Nrf2-related enzymes.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	36-39	NFE2 like bZIP transcription factor 2	Homo sapiens	70-74
23535287-9	2013	These results suggest that the Nrf2/ARE pathway plays an important role in the regulation of CSA-mediated antioxidant effects in HepG2 cells.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	93-96	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
23056567-9	2012	Moreover, CSA reduced the U46619- and PMA-induced phosphorylation of myosin light chain (MLC) at Ser19 and myosin phosphatase target subunit 1 (MYPT1) at Thr853 which was associated with vasoconstriction.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	10-13	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	144-149
23056567-9	2012	Moreover, CSA reduced the U46619- and PMA-induced phosphorylation of myosin light chain (MLC) at Ser19 and myosin phosphatase target subunit 1 (MYPT1) at Thr853 which was associated with vasoconstriction.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	10-13	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	107-142