PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19378035-3	2009	Since posttranslational modifications of many receptor systems are important in initiating signaling, we studied whether tyrosine phosphorylation of TLR4, the principal sensor of Gram-negative bacterial lipopolysaccharide (LPS) plays a role in TLR4 signal-transducing functions.	gram-negative bacterial lipopolysaccharide	179-221	toll like receptor 4	Homo sapiens	149-153
22053092-2	2012	Toll-like receptor 4 (TLR4) on cells of the immune system bind Gram-negative bacterial lipopolysaccharide (LPS), stimulating the secretion of the proinflammatory cytokines interleukin 1B (IL1B) and IL6, and the chemokine IL8.	gram-negative bacterial lipopolysaccharide	63-105	toll like receptor 4	Bos taurus	0-20
22053092-2	2012	Toll-like receptor 4 (TLR4) on cells of the immune system bind Gram-negative bacterial lipopolysaccharide (LPS), stimulating the secretion of the proinflammatory cytokines interleukin 1B (IL1B) and IL6, and the chemokine IL8.	gram-negative bacterial lipopolysaccharide	63-105	toll like receptor 4	Bos taurus	22-26
22053092-2	2012	Toll-like receptor 4 (TLR4) on cells of the immune system bind Gram-negative bacterial lipopolysaccharide (LPS), stimulating the secretion of the proinflammatory cytokines interleukin 1B (IL1B) and IL6, and the chemokine IL8.	gram-negative bacterial lipopolysaccharide	63-105	interleukin 1 beta	Bos taurus	172-186
22053092-2	2012	Toll-like receptor 4 (TLR4) on cells of the immune system bind Gram-negative bacterial lipopolysaccharide (LPS), stimulating the secretion of the proinflammatory cytokines interleukin 1B (IL1B) and IL6, and the chemokine IL8.	gram-negative bacterial lipopolysaccharide	63-105	interleukin 1 beta	Bos taurus	188-192
22053092-2	2012	Toll-like receptor 4 (TLR4) on cells of the immune system bind Gram-negative bacterial lipopolysaccharide (LPS), stimulating the secretion of the proinflammatory cytokines interleukin 1B (IL1B) and IL6, and the chemokine IL8.	gram-negative bacterial lipopolysaccharide	63-105	interferon beta-2	Bos taurus	198-201
22053092-2	2012	Toll-like receptor 4 (TLR4) on cells of the immune system bind Gram-negative bacterial lipopolysaccharide (LPS), stimulating the secretion of the proinflammatory cytokines interleukin 1B (IL1B) and IL6, and the chemokine IL8.	gram-negative bacterial lipopolysaccharide	63-105	C-X-C motif chemokine ligand 8	Bos taurus	221-224
19638630-1	2009	Gram-negative bacterial lipopolysaccharide (LPS) activates macrophages by interacting with Toll-like receptor 4 (TLR4) and triggers the production of various pro-inflammatory Th1 type (type 1) cytokines such as IFNgamma, TNFalpha, and IL8.	gram-negative bacterial lipopolysaccharide	0-42	toll-like receptor 4	Mus musculus	91-111
19638630-1	2009	Gram-negative bacterial lipopolysaccharide (LPS) activates macrophages by interacting with Toll-like receptor 4 (TLR4) and triggers the production of various pro-inflammatory Th1 type (type 1) cytokines such as IFNgamma, TNFalpha, and IL8.	gram-negative bacterial lipopolysaccharide	0-42	toll-like receptor 4	Mus musculus	113-117
19638630-1	2009	Gram-negative bacterial lipopolysaccharide (LPS) activates macrophages by interacting with Toll-like receptor 4 (TLR4) and triggers the production of various pro-inflammatory Th1 type (type 1) cytokines such as IFNgamma, TNFalpha, and IL8.	gram-negative bacterial lipopolysaccharide	0-42	negative elongation factor complex member C/D, Th1l	Mus musculus	175-178
19638630-1	2009	Gram-negative bacterial lipopolysaccharide (LPS) activates macrophages by interacting with Toll-like receptor 4 (TLR4) and triggers the production of various pro-inflammatory Th1 type (type 1) cytokines such as IFNgamma, TNFalpha, and IL8.	gram-negative bacterial lipopolysaccharide	0-42	interferon gamma	Mus musculus	211-219
19638630-1	2009	Gram-negative bacterial lipopolysaccharide (LPS) activates macrophages by interacting with Toll-like receptor 4 (TLR4) and triggers the production of various pro-inflammatory Th1 type (type 1) cytokines such as IFNgamma, TNFalpha, and IL8.	gram-negative bacterial lipopolysaccharide	0-42	tumor necrosis factor	Mus musculus	221-229
19638630-1	2009	Gram-negative bacterial lipopolysaccharide (LPS) activates macrophages by interacting with Toll-like receptor 4 (TLR4) and triggers the production of various pro-inflammatory Th1 type (type 1) cytokines such as IFNgamma, TNFalpha, and IL8.	gram-negative bacterial lipopolysaccharide	0-42	chemokine (C-X-C motif) ligand 15	Mus musculus	235-238
17543887-1	2007	C1 inhibitor (C1INH), a complement regulatory protein, prevents endotoxin shock via a direct interaction of the amino-terminal domain with gram-negative bacterial lipopolysaccharide (LPS).	gram-negative bacterial lipopolysaccharide	139-181	serine (or cysteine) peptidase inhibitor, clade G, member 1	Mus musculus	0-12
18022239-3	2008	Our previous data demonstrated that active, intact C1INH prevents vascular permeability induced by gram-negative bacterial lipopolysaccharide (LPS).	gram-negative bacterial lipopolysaccharide	99-141	serine (or cysteine) peptidase inhibitor, clade G, member 1	Mus musculus	51-56
17543887-1	2007	C1 inhibitor (C1INH), a complement regulatory protein, prevents endotoxin shock via a direct interaction of the amino-terminal domain with gram-negative bacterial lipopolysaccharide (LPS).	gram-negative bacterial lipopolysaccharide	139-181	serine (or cysteine) peptidase inhibitor, clade G, member 1	Mus musculus	14-19
18472833-1	1997	Macrophages harvested from the peritoneal cavities of rats release a neutrophil chemotactic factor (MNCF) in response to stimulation with Gram-negative bacterial lipopolysaccharide (LPS).	gram-negative bacterial lipopolysaccharide	138-180	toll-like receptor 4	Mus musculus	182-185
15039334-1	2004	Toll-like receptor 4 (TLR4) has been identified as a transmembrane protein involved in the host innate immune response to gram-negative bacterial lipopolysaccharide (LPS).	gram-negative bacterial lipopolysaccharide	122-164	toll-like receptor 4	Mus musculus	0-20
15039334-1	2004	Toll-like receptor 4 (TLR4) has been identified as a transmembrane protein involved in the host innate immune response to gram-negative bacterial lipopolysaccharide (LPS).	gram-negative bacterial lipopolysaccharide	122-164	toll-like receptor 4	Mus musculus	22-26
15039334-1	2004	Toll-like receptor 4 (TLR4) has been identified as a transmembrane protein involved in the host innate immune response to gram-negative bacterial lipopolysaccharide (LPS).	gram-negative bacterial lipopolysaccharide	122-164	toll-like receptor 4	Mus musculus	166-169
10565609-2	1999	Several lines of evidence suggest that members of the src family of protein tyrosine kinases play important roles in macrophage activation by gram-negative bacterial lipopolysaccharide (LPS) or the cytokine interferon-gamma (IFN-gamma), but targeted disruption of three members of the src family (hck, fgr, and lyn) in mice failed to demonstrate a requirement for these particular kinases in macrophage activation.	gram-negative bacterial lipopolysaccharide	142-184	FGR proto-oncogene, Src family tyrosine kinase	Mus musculus	54-57
9684908-1	1998	Gram-negative bacterial lipopolysaccharide (LPS) is a well known stimulus for cytokine production, particularly interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha).	gram-negative bacterial lipopolysaccharide	0-42	tumor necrosis factor	Homo sapiens	137-164
9684908-1	1998	Gram-negative bacterial lipopolysaccharide (LPS) is a well known stimulus for cytokine production, particularly interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha).	gram-negative bacterial lipopolysaccharide	0-42	tumor necrosis factor	Homo sapiens	166-175
9396775-1	1997	Gram-negative bacterial lipopolysaccharide (LPS) stimulates phagocytic leukocytes by interacting with the cell surface protein CD14.	gram-negative bacterial lipopolysaccharide	0-42	toll-like receptor 4	Mus musculus	44-47
9396775-1	1997	Gram-negative bacterial lipopolysaccharide (LPS) stimulates phagocytic leukocytes by interacting with the cell surface protein CD14.	gram-negative bacterial lipopolysaccharide	0-42	CD14 antigen	Mus musculus	127-131
2471561-1	1989	Peripheral blood mononuclear cells (PBMs) produce both tissue factor and plasminogen activator inhibitor type 2 (PAI-2) in response to gram-negative bacterial lipopolysaccharide (LPS).	gram-negative bacterial lipopolysaccharide	135-177	serpin family B member 2	Homo sapiens	113-118
9117440-1	1995	We report that gram-negative bacterial lipopolysaccharide (LPS) binds to CD14 on lipid-enriched, low-density domains of the human monocyte-macrophage (THP-1 cell) plasma membrane.	gram-negative bacterial lipopolysaccharide	15-57	CD14 molecule	Homo sapiens	73-77
22576004-1	2012	Human C1 inhibitor (C1INH) prevents endotoxin shock via a direct interaction with Gram-negative bacterial lipopolysaccharide (LPS) and improves survival in animal models of sepsis.	gram-negative bacterial lipopolysaccharide	82-124	serpin family G member 1	Homo sapiens	6-18
26433057-3	2015	Both UCB- and PB-ECFCs had detectable mRNA levels of all the TLRs from 1 to 10; TLR4, a sensor of Gram-negative bacterial lipopolysaccharide (LPS), had a higher level compared to other TLRs.	gram-negative bacterial lipopolysaccharide	98-140	toll like receptor 4	Homo sapiens	80-84
23499552-3	2013	Herein, we show that SCARA5 is an endocytotic receptor whose ligand repertoire includes the typical scavenger receptor ligands, whole bacteria, and purified Gram-negative bacterial lipopolysaccharide.	gram-negative bacterial lipopolysaccharide	157-199	scavenger receptor class A, member 5	Mus musculus	21-27
23071121-2	2013	Strong stimuli, such as Gram-negative bacterial lipopolysaccharide (LPS), induce the simultaneous secretion of cytokines following the activation of NF-kappaB.	gram-negative bacterial lipopolysaccharide	24-66	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	149-158
22576004-1	2012	Human C1 inhibitor (C1INH) prevents endotoxin shock via a direct interaction with Gram-negative bacterial lipopolysaccharide (LPS) and improves survival in animal models of sepsis.	gram-negative bacterial lipopolysaccharide	82-124	serpin family G member 1	Homo sapiens	20-25