PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24759620-0	2014	Kobophenol A inhibits sodium nitroprusside-induced cardiac H9c2 cell death through suppressing activation of JNK and preserving mitochondrial anti-apoptotic Bcl-2 and Mcl-1.	kobophenol A	0-12	mitogen-activated protein kinase 8	Rattus norvegicus	109-112
33577324-0	2021	Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19.	kobophenol A	0-12	angiotensin converting enzyme 2	Homo sapiens	38-42
33577324-0	2021	Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19.	kobophenol A	0-12	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	57-62
30023311-4	2018	We showed that KPA treatment significantly suppressed the production of nitric oxide (NO) by inhibiting inducible nitric oxide synthase (iNOS) expression in a dose-dependent manner without cytotoxicity.	kobophenol A	15-18	nitric oxide synthase 2, inducible	Mus musculus	104-135
30023311-4	2018	We showed that KPA treatment significantly suppressed the production of nitric oxide (NO) by inhibiting inducible nitric oxide synthase (iNOS) expression in a dose-dependent manner without cytotoxicity.	kobophenol A	15-18	nitric oxide synthase 2, inducible	Mus musculus	137-141
24759620-0	2014	Kobophenol A inhibits sodium nitroprusside-induced cardiac H9c2 cell death through suppressing activation of JNK and preserving mitochondrial anti-apoptotic Bcl-2 and Mcl-1.	kobophenol A	0-12	BCL2, apoptosis regulator	Rattus norvegicus	157-162
24759620-0	2014	Kobophenol A inhibits sodium nitroprusside-induced cardiac H9c2 cell death through suppressing activation of JNK and preserving mitochondrial anti-apoptotic Bcl-2 and Mcl-1.	kobophenol A	0-12	MCL1 apoptosis regulator, BCL2 family member	Rattus norvegicus	167-172
24021754-0	2013	Kobophenol A enhances proliferation of human osteoblast-like cells with activation of the p38 pathway.	kobophenol A	0-12	mitogen-activated protein kinase 14	Homo sapiens	90-93
24021754-6	2013	Kobophenol A stimulation induced the expression of the cyclin B1 and cyclin-dependent kinase 1 (CDK1).	kobophenol A	0-12	cyclin B1	Homo sapiens	55-64
24021754-6	2013	Kobophenol A stimulation induced the expression of the cyclin B1 and cyclin-dependent kinase 1 (CDK1).	kobophenol A	0-12	cyclin dependent kinase 1	Homo sapiens	69-94
24021754-6	2013	Kobophenol A stimulation induced the expression of the cyclin B1 and cyclin-dependent kinase 1 (CDK1).	kobophenol A	0-12	cyclin dependent kinase 1	Homo sapiens	96-100
24021754-7	2013	Treatment of osteoblast cells with p38 MAPK inhibitor SB203580 significantly inhibited kobophenol A-enhanced proliferation.	kobophenol A	87-99	mitogen-activated protein kinase 14	Homo sapiens	35-38
24021754-8	2013	In addition, kobophenol A induced phosphorylation of p38 MAPK.	kobophenol A	13-25	mitogen-activated protein kinase 14	Homo sapiens	53-56
24021754-10	2013	Moreover, kobophenol A treatment up-regulated the Bcl-2 level, but down-regulated the level of Bax expression.	kobophenol A	10-22	BCL2 apoptosis regulator	Homo sapiens	50-55
24021754-10	2013	Moreover, kobophenol A treatment up-regulated the Bcl-2 level, but down-regulated the level of Bax expression.	kobophenol A	10-22	BCL2 associated X, apoptosis regulator	Homo sapiens	95-98
24021754-11	2013	We also demonstrate that kobophenol A increased alkaline phosphatase (ALP) activity after 2 days.	kobophenol A	25-37	alkaline phosphatase, placental	Homo sapiens	48-68
24021754-11	2013	We also demonstrate that kobophenol A increased alkaline phosphatase (ALP) activity after 2 days.	kobophenol A	25-37	alkaline phosphatase, placental	Homo sapiens	70-73
24021754-12	2013	Taken together, the results of this study reveal that kobophenol A has proliferative effects and enhances ALP activity in osteoblast cells and these findings provide insights into the development of a therapeutic approach of kobophenol A in the prevention of osteoporosis and other bone disorders.	kobophenol A	54-66	alkaline phosphatase, placental	Homo sapiens	106-109
12518232-0	2003	[The binding sites of estrogen receptor for miyabenol C and kobophenol A].	kobophenol A	60-72	estrogen receptor 1	Homo sapiens	22-39
12518232-1	2003	To examine the binding sites of miyabenol C (Miy C) and kobophenol A ( Kob A) with estrogen receptor (ER), computer modeling was applied to determine 3D structure of Miy C and Kob A. Molecular docking of the components to ER was carried out to find the binding sites between them.	kobophenol A	56-68	estrogen receptor 1	Homo sapiens	83-100
12518232-1	2003	To examine the binding sites of miyabenol C (Miy C) and kobophenol A ( Kob A) with estrogen receptor (ER), computer modeling was applied to determine 3D structure of Miy C and Kob A. Molecular docking of the components to ER was carried out to find the binding sites between them.	kobophenol A	56-68	estrogen receptor 1	Homo sapiens	102-104
12518232-1	2003	To examine the binding sites of miyabenol C (Miy C) and kobophenol A ( Kob A) with estrogen receptor (ER), computer modeling was applied to determine 3D structure of Miy C and Kob A. Molecular docking of the components to ER was carried out to find the binding sites between them.	kobophenol A	56-68	estrogen receptor 1	Homo sapiens	222-224