PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30664848-8	2019	As a corollary, rMTBI also caused persistent decrease in the levels of acetylated histone H3-Lys 9 (H3-K9ac) in promoter region of cocaine- and amphetamine-regulated transcript (CART) gene with concurrent decline in CART mRNA and peptide (CARTp) levels.	rmtbi	16-21	CART prepropeptide	Rattus norvegicus	131-176
33131764-4	2021	We hypothesized that acid sphingomyelinase inhibition would preserve neuronal regeneration and decrease depressive symptoms following rmTBI in a murine model.	rmtbi	134-139	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	21-42
33131764-14	2021	Inhibition of acid sphingomyelinase prevented the harmful neurologic and behavioral effects of rmTBI.	rmtbi	95-100	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	14-35
33099744-3	2021	The current study investigates the role of DNA methylation in SOD2 gene regulation and its involvement in rMTBI-induced persistent neuropathology inflicted by weight drop injury paradigm.	rmtbi	106-111	superoxide dismutase 2	Homo sapiens	62-66
33099744-5	2021	The temporal and episodic increase in ROS levels (oxidative stress) heightened 8-hydroxyguanosine levels indicating oxidative damage after rMTBI that was concomitant with decline in SOD2 function.	rmtbi	139-144	superoxide dismutase 2	Homo sapiens	182-186
33099744-6	2021	In parallel, occupancy of DNMT3b at SOD2 promoter was higher post 30 days of the first episode of rMTBI causing hypermethylation at SOD2 promoter.	rmtbi	98-103	DNA methyltransferase 3 beta	Homo sapiens	26-32
33099744-6	2021	In parallel, occupancy of DNMT3b at SOD2 promoter was higher post 30 days of the first episode of rMTBI causing hypermethylation at SOD2 promoter.	rmtbi	98-103	superoxide dismutase 2	Homo sapiens	36-40
33099744-6	2021	In parallel, occupancy of DNMT3b at SOD2 promoter was higher post 30 days of the first episode of rMTBI causing hypermethylation at SOD2 promoter.	rmtbi	98-103	superoxide dismutase 2	Homo sapiens	132-136
33099744-7	2021	This epigenetic silencing of SOD2 promoter was sustained after the second episode of rMTBI causing permanent blockade in SOD2 response.	rmtbi	85-90	superoxide dismutase 2	Homo sapiens	29-33
33099744-7	2021	This epigenetic silencing of SOD2 promoter was sustained after the second episode of rMTBI causing permanent blockade in SOD2 response.	rmtbi	85-90	superoxide dismutase 2	Homo sapiens	121-125
33099744-9	2021	The treatment with 5-azacytidine, a pan DNMT inhibitor, normalized DNA methylation levels and revived SOD2 function after the second episode of rMTBI.	rmtbi	144-149	DNA methyltransferase 1	Homo sapiens	40-44
33099744-9	2021	The treatment with 5-azacytidine, a pan DNMT inhibitor, normalized DNA methylation levels and revived SOD2 function after the second episode of rMTBI.	rmtbi	144-149	superoxide dismutase 2	Homo sapiens	102-106
33291119-9	2021	Concurrently, the acetylated H3-K9 levels and the binding of CBP at the NPY promoter in the Arc of the rMTBI-exposed rats were reduced.	rmtbi	103-108	CREB binding protein	Rattus norvegicus	61-64
33291119-9	2021	Concurrently, the acetylated H3-K9 levels and the binding of CBP at the NPY promoter in the Arc of the rMTBI-exposed rats were reduced.	rmtbi	103-108	neuropeptide Y	Rattus norvegicus	72-75
33291119-10	2021	However, the treatment with sodium butyrate corrected the rMTBI-induced deficits in the H3-K9 acetylation levels and CBP occupancy at the NPY promoter, restoring both the NPY expression and the food intake.	rmtbi	58-63	CREB binding protein	Rattus norvegicus	117-120
33291119-10	2021	However, the treatment with sodium butyrate corrected the rMTBI-induced deficits in the H3-K9 acetylation levels and CBP occupancy at the NPY promoter, restoring both the NPY expression and the food intake.	rmtbi	58-63	neuropeptide Y	Rattus norvegicus	138-141
33291119-10	2021	However, the treatment with sodium butyrate corrected the rMTBI-induced deficits in the H3-K9 acetylation levels and CBP occupancy at the NPY promoter, restoring both the NPY expression and the food intake.	rmtbi	58-63	neuropeptide Y	Rattus norvegicus	171-174
32958852-4	2020	Cell fate analysis showed a greater number of BrdU-labeled cells which co-expressed Prox-1 in the DG of rmTBI-injured mice which coincided with enhanced cFos expression for neuronal activity.	rmtbi	104-109	prospero homeobox 1	Mus musculus	84-90
32958852-4	2020	Cell fate analysis showed a greater number of BrdU-labeled cells which co-expressed Prox-1 in the DG of rmTBI-injured mice which coincided with enhanced cFos expression for neuronal activity.	rmtbi	104-109	FBJ osteosarcoma oncogene	Mus musculus	153-157
31843449-5	2020	We demonstrated that miR-124-3p level in microglial exosomes from injured brain was significantly altered in the acute, sub-acute, and chronic phases after rmTBI.	rmtbi	156-161	microRNA 124a-3	Mus musculus	21-31
30672378-11	2019	Post-rmTBI administration of CA significantly improved motor and cognitive function, and decreased Gfap and Iba1 immunoreactivities within white matter tracks.	rmtbi	5-10	glial fibrillary acidic protein	Mus musculus	99-103
30664848-8	2019	As a corollary, rMTBI also caused persistent decrease in the levels of acetylated histone H3-Lys 9 (H3-K9ac) in promoter region of cocaine- and amphetamine-regulated transcript (CART) gene with concurrent decline in CART mRNA and peptide (CARTp) levels.	rmtbi	16-21	CART prepropeptide	Rattus norvegicus	178-182
30664848-8	2019	As a corollary, rMTBI also caused persistent decrease in the levels of acetylated histone H3-Lys 9 (H3-K9ac) in promoter region of cocaine- and amphetamine-regulated transcript (CART) gene with concurrent decline in CART mRNA and peptide (CARTp) levels.	rmtbi	16-21	CART prepropeptide	Rattus norvegicus	216-220
30664848-8	2019	As a corollary, rMTBI also caused persistent decrease in the levels of acetylated histone H3-Lys 9 (H3-K9ac) in promoter region of cocaine- and amphetamine-regulated transcript (CART) gene with concurrent decline in CART mRNA and peptide (CARTp) levels.	rmtbi	16-21	CART prepropeptide	Rattus norvegicus	239-244
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	NLR family, pyrin domain containing 3	Mus musculus	84-89
30070145-5	2019	rmTBI induced oxidative stress in endothelial cells and nitric oxide (NO) generation in astrocytes, which were mediated by hypoxia and increased hypoxia-inducible factor 1-alpha (HIF1alpha).	rmtbi	0-5	hypoxia inducible factor 1, alpha subunit	Mus musculus	145-177
30070145-5	2019	rmTBI induced oxidative stress in endothelial cells and nitric oxide (NO) generation in astrocytes, which were mediated by hypoxia and increased hypoxia-inducible factor 1-alpha (HIF1alpha).	rmtbi	0-5	hypoxia inducible factor 1, alpha subunit	Mus musculus	179-188
30384417-9	2018	rmTBI resulted in increases in microglial cell density, antioxidant responses (manganese-dependent superoxide dismutase (MnSOD) immunoreactivity), and alterations to node of Ranvier structure.	rmtbi	0-5	superoxide dismutase 2	Rattus norvegicus	79-119
30384417-9	2018	rmTBI resulted in increases in microglial cell density, antioxidant responses (manganese-dependent superoxide dismutase (MnSOD) immunoreactivity), and alterations to node of Ranvier structure.	rmtbi	0-5	superoxide dismutase 2	Rattus norvegicus	121-126
28412305-2	2018	Targeted therapies for rmTBI are lacking, though evidence from other injury models indicates that targeting N-methyl-d-aspartate (NMDA) receptor (NMDAR)-mediated glutamatergic toxicity might mitigate rmTBI-induced neurologic deficits.	rmtbi	23-28	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	146-151
28412305-2	2018	Targeted therapies for rmTBI are lacking, though evidence from other injury models indicates that targeting N-methyl-d-aspartate (NMDA) receptor (NMDAR)-mediated glutamatergic toxicity might mitigate rmTBI-induced neurologic deficits.	rmtbi	200-205	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	146-151
28390198-9	2017	IL-6/IL-10 showed a similar pattern, whose rise corresponded to the decrease in TNF-alpha at week 2 after rmTBI.	rmtbi	106-111	interleukin 6	Rattus norvegicus	0-4
28390198-9	2017	IL-6/IL-10 showed a similar pattern, whose rise corresponded to the decrease in TNF-alpha at week 2 after rmTBI.	rmtbi	106-111	interleukin 10	Rattus norvegicus	5-10
28390198-9	2017	IL-6/IL-10 showed a similar pattern, whose rise corresponded to the decrease in TNF-alpha at week 2 after rmTBI.	rmtbi	106-111	tumor necrosis factor	Rattus norvegicus	80-89
34508891-5	2021	rMTBI-induced hypermethylation at TFAM promoter resulted in deficits in its protein levels in mitochondria after immediate (48 h) and protracted (30 d) time points.	rmtbi	0-5	transcription factor A, mitochondrial	Rattus norvegicus	34-38
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	caspase 1	Mus musculus	91-100
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	PYD and CARD domain containing	Mus musculus	106-163
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	PYD and CARD domain containing	Mus musculus	165-168
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	171-193
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	195-204
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	interleukin 1 beta	Mus musculus	207-224
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	interleukin 1 alpha	Mus musculus	226-234
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	interleukin 18	Mus musculus	237-251
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	interleukin 18	Mus musculus	253-258
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	261-304
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	306-310
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	heme oxygenase 1	Mus musculus	316-332
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	heme oxygenase 1	Mus musculus	334-339
34506597-11	2021	These results suggest that NLRP3 inflammasome activation and the subsequent inflammatory response in the mice cortex are involved in the process of rmTBI.	rmtbi	148-153	NLR family, pyrin domain containing 3	Mus musculus	27-32