PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 8788128-1 1995 The ability of a nitroxyl fatty acid (NFA) to bind specifically to albumin is abolished when, in the absence of stabilizers, a 4% solution of this protein is heated above a critical temperature of 60 degrees C. This treatment leads to the formation of "albumin polymers" as classically evidenced by GPC. nfa 38-41 glycophorin C (Gerbich blood group) Homo sapiens 299-302 34675975-10 2021 The mRNA levels of CYP11B2, HTR4, and AQP2 were significantly increased in APA samples compared to NFA (24.420 folds of NFA, p < 0.001; 3.753 folds of NFA, p = 0.002; and 11.487 folds of NFA, p = 0.018). nfa 99-102 5-hydroxytryptamine receptor 4 Homo sapiens 28-32 1491612-6 1992 Globotriaosylceramide (Gb3) is found at 50 nM and 73 nM for the NFA and HFA species, respectively, while globoside (Gb4) is found at 45 nM and 46 nM for the NFA and HFA species. nfa 64-67 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 23-26 34675975-10 2021 The mRNA levels of CYP11B2, HTR4, and AQP2 were significantly increased in APA samples compared to NFA (24.420 folds of NFA, p < 0.001; 3.753 folds of NFA, p = 0.002; and 11.487 folds of NFA, p = 0.018). nfa 120-123 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 19-26 34675975-10 2021 The mRNA levels of CYP11B2, HTR4, and AQP2 were significantly increased in APA samples compared to NFA (24.420 folds of NFA, p < 0.001; 3.753 folds of NFA, p = 0.002; and 11.487 folds of NFA, p = 0.018). nfa 120-123 5-hydroxytryptamine receptor 4 Homo sapiens 28-32 34675975-10 2021 The mRNA levels of CYP11B2, HTR4, and AQP2 were significantly increased in APA samples compared to NFA (24.420 folds of NFA, p < 0.001; 3.753 folds of NFA, p = 0.002; and 11.487 folds of NFA, p = 0.018). nfa 120-123 aquaporin 2 Homo sapiens 38-42 34675975-10 2021 The mRNA levels of CYP11B2, HTR4, and AQP2 were significantly increased in APA samples compared to NFA (24.420 folds of NFA, p < 0.001; 3.753 folds of NFA, p = 0.002; and 11.487 folds of NFA, p = 0.018). nfa 151-154 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 19-26 34675975-10 2021 The mRNA levels of CYP11B2, HTR4, and AQP2 were significantly increased in APA samples compared to NFA (24.420 folds of NFA, p < 0.001; 3.753 folds of NFA, p = 0.002; and 11.487 folds of NFA, p = 0.018). nfa 151-154 5-hydroxytryptamine receptor 4 Homo sapiens 28-32 34675975-10 2021 The mRNA levels of CYP11B2, HTR4, and AQP2 were significantly increased in APA samples compared to NFA (24.420 folds of NFA, p < 0.001; 3.753 folds of NFA, p = 0.002; and 11.487 folds of NFA, p = 0.018). nfa 151-154 aquaporin 2 Homo sapiens 38-42 34675975-10 2021 The mRNA levels of CYP11B2, HTR4, and AQP2 were significantly increased in APA samples compared to NFA (24.420 folds of NFA, p < 0.001; 3.753 folds of NFA, p = 0.002; and 11.487 folds of NFA, p = 0.018). nfa 187-190 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 19-26 34675975-10 2021 The mRNA levels of CYP11B2, HTR4, and AQP2 were significantly increased in APA samples compared to NFA (24.420 folds of NFA, p < 0.001; 3.753 folds of NFA, p = 0.002; and 11.487 folds of NFA, p = 0.018). nfa 187-190 5-hydroxytryptamine receptor 4 Homo sapiens 28-32 34675975-10 2021 The mRNA levels of CYP11B2, HTR4, and AQP2 were significantly increased in APA samples compared to NFA (24.420 folds of NFA, p < 0.001; 3.753 folds of NFA, p = 0.002; and 11.487 folds of NFA, p = 0.018). nfa 187-190 aquaporin 2 Homo sapiens 38-42 30093786-8 2018 However, NFA did not increase the mutation frequency in the kidneys, despite the increased 8-OHdG in NFA-treated Nrf2-/- mice. nfa 101-104 nuclear factor, erythroid derived 2, like 2 Mus musculus 113-117 35561478-5 2022 Intratracheal (IT) and intraperitoneal (IP) administration of NFA notably attenuated hyperoxia-induced infiltration of inflammatory cells, alveolar-capillary leakage, upregulation of proinflammatory cytokine levels (IL-6 and TNFalpha) into the BAL fluid, and resolution of inflammation in the lung. nfa 62-65 interleukin 6 Mus musculus 216-220 35561478-5 2022 Intratracheal (IT) and intraperitoneal (IP) administration of NFA notably attenuated hyperoxia-induced infiltration of inflammatory cells, alveolar-capillary leakage, upregulation of proinflammatory cytokine levels (IL-6 and TNFalpha) into the BAL fluid, and resolution of inflammation in the lung. nfa 62-65 tumor necrosis factor Mus musculus 225-233 33494976-8 2021 The mean NFA in the SCP differed according to diabetes type and stage of DR (type 1 diabetes: NPDR, 0.76+-0.3, PDR, 1.24+-0.7; type 2 diabetes: NPDR, 1.46+-0.7, PDR, 1.57+-0.7). nfa 9-12 urocortin 3 Homo sapiens 20-23 32988141-6 2020 Results: Compared to NFA group, ACS patients had lower DHEAS levels [0.39 (0.39, 0.63) mumol/L vs 2.96 (1.92, 4.60) mumol/L, P<0.01] and lower DHEAS ratio [0.58 (0.27, 0.98) vs 3.95 (3.08, 6.83), P<0.01]. nfa 21-24 sulfotransferase family 2A member 1 Homo sapiens 55-60 32390241-3 2020 Two NFAs, BTP-S1 and BTP-S2, are constructed by introducing halogenated indandione (A1 ) and 3-dicyanomethylene-1-indanone (A2 ) as two different conjugated terminals on the central fused core (D), wherein they share the same backbone as well-known NFA Y6, but at different terminals. nfa 4-7 APC regulator of WNT signaling pathway Homo sapiens 21-27 29909078-2 2018 These NFA effects are mediated by targeting important regulatory proteins involved in inflammatory processes, such as 5-lipoxygenase, soluble epoxide hydrolase, or NF-kappaB. nfa 6-9 arachidonate 5-lipoxygenase Homo sapiens 118-132 29909078-2 2018 These NFA effects are mediated by targeting important regulatory proteins involved in inflammatory processes, such as 5-lipoxygenase, soluble epoxide hydrolase, or NF-kappaB. nfa 6-9 nuclear factor kappa B subunit 1 Homo sapiens 164-173 30093786-5 2018 To clarify the role of oxidative stress in the chemical structure-related genotoxic mechanism of NFT, we performed reporter gene mutation assays for NFT and 5-nitro-2-furaldehyde (NFA) using Nrf2-proficient and Nrf2-deficient gpt delta mice. nfa 180-183 nuclear factor, erythroid derived 2, like 2 Mus musculus 191-195 28514805-10 2017 CPA and NFA also exhibited extensive low or moderate DAB2 expression. nfa 8-11 DAB adaptor protein 2 Homo sapiens 53-57 28931176-6 2018 RESULTS: The cortisol/ACTH ratios at all time points were significantly higher in the SHC group than the NFA group (P<0.05) and were significantly correlated with serum cortisol levels after the 1-mg dexamethasone suppression test (DST). nfa 105-108 proopiomelanocortin Homo sapiens 22-26 27823964-1 2017 Recently, we published that nitro-fatty acids (NFA) are potent electrophilic molecules which inhibit 5-lipoxygenase (5-LO) by interacting catalytically with cysteine residues next to a substrate entry channel. nfa 47-50 arachidonate 5-lipoxygenase Homo sapiens 101-115 25772432-6 2015 An increase in gpt MF was also observed in the NFA-treated group at 13 weeks, but not in the AHD-treated group. nfa 47-50 glutamic--pyruvic transaminase Rattus norvegicus 15-18 27119365-4 2016 NFA (10-nitro-oleic acid or 12-nitrolinoleic acid) treatment downregulated expression and activity of the inflammatory transcription factor NF-kappaB while upregulating those of PPARgamma. nfa 0-3 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 140-149 27119365-4 2016 NFA (10-nitro-oleic acid or 12-nitrolinoleic acid) treatment downregulated expression and activity of the inflammatory transcription factor NF-kappaB while upregulating those of PPARgamma. nfa 0-3 peroxisome proliferator activated receptor gamma Mus musculus 178-187 22851714-1 2012 Niflumic acid, 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid (NFA), a nonsteroidal anti-inflammatory drug that blocks cyclooxygenase (COX), was shown previously to activate [Na(+)](i)-regulated Slo2.1 channels. nfa 79-82 potassium sodium-activated channel subfamily T member 2 Homo sapiens 211-217 22851714-7 2012 A point mutation (A278R) in the pore-lining S6 segment of Slo2.1 increased the sensitivity to activation and reduced the inhibition induced by NFA. nfa 143-146 potassium sodium-activated channel subfamily T member 2 Homo sapiens 58-64 18420598-6 2008 Monohydroxy-ceramides, tLCB-NFA (Cer 2) and dLCB-HFA (Cer 3), exhibited stronger activities, whereas dihydroxy-ceramides, tLCB-HFA (Cer 4), exhibited similar or weaker activity than dLCB-NFA (Cer 1), depending on cell lines. nfa 28-31 cerberus 1, DAN family BMP antagonist Equus caballus 192-197 15968630-9 2005 In contrast to wild-type and rescued mice, PLP-CGT transgenic mice on a wild-type background exhibited significantly elevated CGT activity which directly correlated with an increase in non-hydroxy fatty acid (NFA)-GalC, but not alpha-hydroxy fatty acid (HFA)-GalC. nfa 209-212 proteolipid protein (myelin) 1 Mus musculus 43-46 15968630-9 2005 In contrast to wild-type and rescued mice, PLP-CGT transgenic mice on a wild-type background exhibited significantly elevated CGT activity which directly correlated with an increase in non-hydroxy fatty acid (NFA)-GalC, but not alpha-hydroxy fatty acid (HFA)-GalC. nfa 209-212 UDP galactosyltransferase 8A Mus musculus 47-50 15968630-9 2005 In contrast to wild-type and rescued mice, PLP-CGT transgenic mice on a wild-type background exhibited significantly elevated CGT activity which directly correlated with an increase in non-hydroxy fatty acid (NFA)-GalC, but not alpha-hydroxy fatty acid (HFA)-GalC. nfa 209-212 galactosylceramidase Mus musculus 214-218 11380493-6 2001 ACTH receptor mRNA followed a similar pattern (CPA 178 +/- 17, APA 196 +/- 30, NFA 0%, carcinomas 56 +/- 11%) with a good correlation between Ang II type 1 receptor and ACTH-R mRNA of r = 0.692, P = 0.0019. nfa 79-82 melanocortin 2 receptor Homo sapiens 0-13 12414859-4 2002 VEGF expression, calculated as the percentage of positive cells, was significantly greater (P < 0.0001) in CA (85.3 +/- 2.1) than in APA (56.5 +/- 7.5), CPA (38.5 +/- 7.0), N (33.1 +/- 6.1), and NFA (0.76 +/- 0.6). nfa 198-201 vascular endothelial growth factor A Homo sapiens 0-4 11179369-4 2001 This upregulation was specific for Gb3 species containing normal fatty acids (NFA). nfa 78-81 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 35-38 10971451-10 2000 In particular, both recurrent and nonrecurrent NFA showed significantly higher cyclin D LI than other tumours. nfa 47-50 proliferating cell nuclear antigen Homo sapiens 79-85 9582497-8 1998 Northern analysis using dot blot was employed to quantify ACTH-R and GR mRNA expression and confirmed the ISH data: ACTH-R mRNA expression was high in CPAs (275 and 195% vs 100 +/- 25% in adult adrenals), APAs (127, 200 and 221%) and two carcinomas (99 and 132%), but low in the NFA (7%) and in an androgen secreting carcinoma (16%). nfa 279-282 melanocortin 2 receptor Homo sapiens 116-122 9741827-7 1998 In PMHP and NFA, met-enkephalin-Arg-Phe immunoreactivity was detected in intermediate- and low-mol-wt materials, and it was absent in GH-PA. nfa 12-15 proopiomelanocortin Homo sapiens 17-31 9582497-9 1998 GR mRNA expression was high in the NFA (195%) and in two of three carcinomas (93, 188, 227%). nfa 35-38 nuclear receptor subfamily 3 group C member 1 Homo sapiens 0-2