PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 28440767-8 2017 In a univariate analysis, ZAG levels positively correlated to 24-h urinary free cortisol (p=0.001), body mass index (p=0.02), non-esterified fatty acids (p=0.05), glucose (p=0.003), LDL-C (p=0.028), and type 2 diabetes mellitus (p=0.016), and were inversely related to total adiponectin levels (p=0.035). esterified 130-140 alpha-2-glycoprotein 1, zinc-binding Homo sapiens 26-29 28871187-9 2017 The underlying mechanism may depend on increased hepatic glycolytic flux due to increased pkm2 expression and consequent conversion of pyruvate to non-esterified fatty acid synthesis due to increased CS activity and ACLY levels. esterified 151-161 citrate synthase Rattus norvegicus 200-202 28871187-9 2017 The underlying mechanism may depend on increased hepatic glycolytic flux due to increased pkm2 expression and consequent conversion of pyruvate to non-esterified fatty acid synthesis due to increased CS activity and ACLY levels. esterified 151-161 ATP citrate lyase Rattus norvegicus 216-220 26356502-3 2015 Of particular interest is the intertwined regulation of glucose and non-esterified fatty acids (NEFA), due to the association between disturbed NEFA metabolism and insulin resistance. esterified 72-82 insulin Homo sapiens 164-171 26853749-3 2016 Treatment with pharmacological doses of FGF21 acutely reduced plasma non-esterified fatty acids (NEFAs), liver TG content, and VLDL-TG secretion. esterified 73-83 fibroblast growth factor 21 Mus musculus 40-45 26705406-11 2015 A fat tolerance test evidenced delayed plasma triglyceride clearance and greater transient availability of non-esterified fatty acids (NEFA) during the post-prandial state in the apoCIII mice plasma. esterified 111-121 apolipoprotein C-III Mus musculus 179-186 22738231-2 2012 As observed with many enzymes, Ypc1p can also catalyse the reverse reaction, i.e. condense a non-esterified fatty acid with PHS (phytosphingosine) or DHS (dihydrosphingosine) and thus synthesize ceramides. esterified 97-107 phytoceramidase Saccharomyces cerevisiae S288C 31-36 24204574-6 2013 The plasma levels of non-esterified fatty acids were significantly lower in the Herp(-/-); apoE(-/-) mice when they were eight and 16 weeks old. esterified 25-35 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 Mus musculus 80-84 20460954-1 2011 BACKGROUND: Altered secretion of adipokines and non-esterified fatty acid (NEFA) seems to play a pivotal role in the abdominal obesity-related insulin resistance (IR). esterified 52-62 insulin Homo sapiens 143-150 22944699-2 2012 The hydrolytic cleavage of triacylglycerol by adipose triglyceride lipase (ATGL) generates non-esterified fatty acids, which are subsequently used as essential precursors for lipid and membrane synthesis, mediators in cell signaling processes or as energy substrate in mitochondria. esterified 95-105 patatin like phospholipase domain containing 2 Homo sapiens 46-73 22944699-2 2012 The hydrolytic cleavage of triacylglycerol by adipose triglyceride lipase (ATGL) generates non-esterified fatty acids, which are subsequently used as essential precursors for lipid and membrane synthesis, mediators in cell signaling processes or as energy substrate in mitochondria. esterified 95-105 patatin like phospholipase domain containing 2 Homo sapiens 75-79 11728630-1 2001 Phosphoenolpyruvate carboxykinase (PEPCK) is the key enzyme in glyceroneogenesis, an important metabolic pathway that functions to restrain the release of non-esterified fatty acids (NEFAs) from adipocytes. esterified 159-169 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 0-33 15684343-5 2005 Administration of PRL resulted in an acute increase in colonic temperature in conjunction with increased plasma concentrations of non-esterified fatty acids and, as a result, the normal postnatal decline in body temperature was delayed. esterified 134-144 prolactin Ovis aries 18-21 17291802-9 2007 In addition, it was observed that central administration of both VIP and PACAP induced a reduction in respiratory quotient and increased plasma non-esterified fatty acid concentrations. esterified 148-158 vasoactive intestinal peptide Gallus gallus 65-68 17291802-9 2007 In addition, it was observed that central administration of both VIP and PACAP induced a reduction in respiratory quotient and increased plasma non-esterified fatty acid concentrations. esterified 148-158 adenylate cyclase activating polypeptide 1 Gallus gallus 73-78 11728630-1 2001 Phosphoenolpyruvate carboxykinase (PEPCK) is the key enzyme in glyceroneogenesis, an important metabolic pathway that functions to restrain the release of non-esterified fatty acids (NEFAs) from adipocytes. esterified 159-169 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 35-40 10952470-2 2000 It is hypothesised that the primary route by which insulin maintains control over glucose production is indirect and is mediated by regulation of non-esterified fatty acid release from the adipocyte. esterified 150-160 insulin Canis lupus familiaris 51-58 11589678-1 2001 OBJECTIVE: High non-esterified fatty acid (NEFA) levels impair glucose-stimulated insulin secretion from islets derived from non-diabetic Zucker rats that are genetically predisposed to diabetes. esterified 20-30 insulin Homo sapiens 82-89 2100741-3 1990 Removing the associated lipid from the perfusate albumin reduced the amount of non-esterified fatty acid (NEFA) transfer rather than enhanced it. esterified 83-93 albumin Cavia porcellus 49-56 10768092-7 2000 Hepatic lipase-mediated non-esterified fatty acid release from HDL lipids was enhanced in glycated HDL compared with control HDL (25 +/- 1 vs 16 +/- 1 nmol non-esterified fatty acid hydrolysed/min, respectively, p < 0.0001). esterified 28-38 lipase C, hepatic type Homo sapiens 0-14 9566856-7 1998 We conclude that abdominal obesity is associated with a higher resistance to insulin mediated suppression of non-esterified fatty acids in obese subjects. esterified 113-123 insulin Homo sapiens 77-84 8582538-1 1995 Our study investigates short- and long-term effects of infusion of non-esterified fatty acids (NEFA) on insulin secretion in healthy subjects. esterified 71-81 insulin Homo sapiens 104-111 1587994-3 1992 Moreover, the SHR showed greater sensitivity to CCl4 stimulation in the sympathetic nervous system than the WKY, resulting in a decreased hepatic blood flow in the acute stage and a depleted CA in the adrenal gland, a lowered blood pressure (BP) and a released non-esterified fatty acid (NEFA) from peripheral adipose tissue in the chronic stage. esterified 265-275 C-C motif chemokine ligand 4 Rattus norvegicus 48-52 7867881-2 1994 Fed GLUT 4 transgenic mice exhibited a 32% and 56% reduction in serum glucose and insulin and a 69% and 33% increase in non-esterified fatty acid and lactate levels, respectively. esterified 124-134 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 4-10 8243878-7 1993 The present results demonstrate that insulin-like growth factor I is capable of mimicking the acute effects of insulin on metabolic substrates (plasma glucose, non-esterified fatty acids, leucine). esterified 164-174 insulin like growth factor 1 Homo sapiens 37-65 8243878-7 1993 The present results demonstrate that insulin-like growth factor I is capable of mimicking the acute effects of insulin on metabolic substrates (plasma glucose, non-esterified fatty acids, leucine). esterified 164-174 insulin Homo sapiens 37-44 3084268-1 1986 A method for determination of reserve albumin equivalent for binding of warfarin as previously described [1] has been used for assessing the influence of non-esterified fatty acid concentration (NEFA) on binding of warfarin to human serum albumin (HSA). esterified 158-168 albumin Homo sapiens 233-246