PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32443870-6	2020	Terpineol showed a coherent predicted binding mode mainly against CB1 and CB2 receptors and also against the D2 receptor during docking modeling analyses.	alpha-terpineol	0-9	cannabinoid receptor 1	Homo sapiens	66-69
34846548-9	2022	Compared to wild type mice, CB1R (-/-) mice treated with alpha-terpineol displayed a 2.91-fold decrease in potency to reverse mechanical allodynia; in CB2R (-/-) mice, the potency of alpha-terpineol was decreased 11.73-fold.	alpha-terpineol	57-72	cannabinoid receptor 1 (brain)	Mus musculus	28-32
34846548-9	2022	Compared to wild type mice, CB1R (-/-) mice treated with alpha-terpineol displayed a 2.91-fold decrease in potency to reverse mechanical allodynia; in CB2R (-/-) mice, the potency of alpha-terpineol was decreased 11.73-fold.	alpha-terpineol	183-198	cannabinoid receptor 2 (macrophage)	Mus musculus	151-155
21196321-1	2011	The sage components linalyl acetate (Ly) and alpha-terpineol (Te) exhibit synergistic anti-proliferative effects.	alpha-terpineol	45-60	sarcoma antigen 1	Homo sapiens	4-8
20651334-0	2010	Alpha terpineol: a potential anticancer agent which acts through suppressing NF-kappaB signalling.	alpha-terpineol	0-15	nuclear factor kappa B subunit 1	Homo sapiens	77-86
20651334-5	2010	The results proposed alpha terpineol as an NF-kappaB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappaB translocation and activity using two NF-kappaB assays, and by the down-regulation of the expression of several NF-kappaB-related genes such as IL-1 beta and IL1R1.	alpha-terpineol	27-36	nuclear factor kappa B subunit 1	Homo sapiens	43-52
20651334-5	2010	The results proposed alpha terpineol as an NF-kappaB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappaB translocation and activity using two NF-kappaB assays, and by the down-regulation of the expression of several NF-kappaB-related genes such as IL-1 beta and IL1R1.	alpha-terpineol	27-36	nuclear factor kappa B subunit 1	Homo sapiens	129-138
20651334-5	2010	The results proposed alpha terpineol as an NF-kappaB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappaB translocation and activity using two NF-kappaB assays, and by the down-regulation of the expression of several NF-kappaB-related genes such as IL-1 beta and IL1R1.	alpha-terpineol	27-36	nuclear factor kappa B subunit 1	Homo sapiens	129-138
20651334-5	2010	The results proposed alpha terpineol as an NF-kappaB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappaB translocation and activity using two NF-kappaB assays, and by the down-regulation of the expression of several NF-kappaB-related genes such as IL-1 beta and IL1R1.	alpha-terpineol	27-36	nuclear factor kappa B subunit 1	Homo sapiens	129-138
20651334-5	2010	The results proposed alpha terpineol as an NF-kappaB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappaB translocation and activity using two NF-kappaB assays, and by the down-regulation of the expression of several NF-kappaB-related genes such as IL-1 beta and IL1R1.	alpha-terpineol	27-36	interleukin 1 beta	Homo sapiens	282-291
20651334-5	2010	The results proposed alpha terpineol as an NF-kappaB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappaB translocation and activity using two NF-kappaB assays, and by the down-regulation of the expression of several NF-kappaB-related genes such as IL-1 beta and IL1R1.	alpha-terpineol	27-36	interleukin 1 receptor type 1	Homo sapiens	296-301
20651334-6	2010	CONCLUSION: The results suggest that alpha terpineol inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway.	alpha-terpineol	37-52	nuclear factor kappa B subunit 1	Homo sapiens	141-150
17867636-9	2007	This anti-inflammatory effect of alpha-terpineol on IL-6 formation was verified by quantitative real-time reverse transcription Polymerase Chain Reaction experiments in which alpha-terpineol inhibited the gene expression of the IL-6 receptor.	alpha-terpineol	33-48	interleukin 6	Homo sapiens	52-56
17867636-9	2007	This anti-inflammatory effect of alpha-terpineol on IL-6 formation was verified by quantitative real-time reverse transcription Polymerase Chain Reaction experiments in which alpha-terpineol inhibited the gene expression of the IL-6 receptor.	alpha-terpineol	33-48	interleukin 6	Homo sapiens	228-232
17867636-9	2007	This anti-inflammatory effect of alpha-terpineol on IL-6 formation was verified by quantitative real-time reverse transcription Polymerase Chain Reaction experiments in which alpha-terpineol inhibited the gene expression of the IL-6 receptor.	alpha-terpineol	175-190	interleukin 6	Homo sapiens	52-56
17867636-9	2007	This anti-inflammatory effect of alpha-terpineol on IL-6 formation was verified by quantitative real-time reverse transcription Polymerase Chain Reaction experiments in which alpha-terpineol inhibited the gene expression of the IL-6 receptor.	alpha-terpineol	175-190	interleukin 6	Homo sapiens	228-232
32443870-10	2020	In summary, molecular docking suggests that CB1 and CB2 receptors are the most promising targets of terpineol action.	alpha-terpineol	100-109	cannabinoid receptor 2	Homo sapiens	52-55
32443870-11	2020	Our data showed terpineol antidepressant-like modulation by CB1 and CB2 cannabinoid receptors and D2-dopaminergic receptors to further corroborate our molecular evidence.	alpha-terpineol	16-25	cannabinoid receptor 1	Homo sapiens	60-63
32443870-11	2020	Our data showed terpineol antidepressant-like modulation by CB1 and CB2 cannabinoid receptors and D2-dopaminergic receptors to further corroborate our molecular evidence.	alpha-terpineol	16-25	cannabinoid receptor 2	Homo sapiens	68-71
32443870-6	2020	Terpineol showed a coherent predicted binding mode mainly against CB1 and CB2 receptors and also against the D2 receptor during docking modeling analyses.	alpha-terpineol	0-9	cannabinoid receptor 2	Homo sapiens	74-77
32443870-10	2020	In summary, molecular docking suggests that CB1 and CB2 receptors are the most promising targets of terpineol action.	alpha-terpineol	100-109	cannabinoid receptor 1	Homo sapiens	44-47
32382672-5	2020	The intake of alpha-terpineol at concentrations >=50 mg/kg was able to reestablish the insulin sensibility and reduced (p < 0.05) serum levels of pro-inflammatory cytokines TNF-alpha and IL-1beta, when compared with the control group.	alpha-terpineol	14-29	tumor necrosis factor	Rattus norvegicus	173-182
32382672-5	2020	The intake of alpha-terpineol at concentrations >=50 mg/kg was able to reestablish the insulin sensibility and reduced (p < 0.05) serum levels of pro-inflammatory cytokines TNF-alpha and IL-1beta, when compared with the control group.	alpha-terpineol	14-29	interleukin 1 alpha	Rattus norvegicus	187-195
32382672-6	2020	The intake of R-(+)- and (-)-alpha-terpineol decreased the TNF-alpha level by approximately 1.5 and 3.4 times, respectively, when compared with the high-fat group, regardless of the concentration.	alpha-terpineol	27-44	tumor necrosis factor	Rattus norvegicus	59-68
29902764-0	2018	alpha-Terpineol reduces cancer pain via modulation of oxidative stress and inhibition of iNOS.	alpha-terpineol	0-15	nitric oxide synthase 2, inducible	Mus musculus	89-93
31617532-7	2019	alpha-Terpineol at a concentration found in fresh cranberries (1.16 mug mL-1) was also found to be effective in reducing NO production whether cells were treated before or after application of LPS.	alpha-terpineol	0-15	L1 cell adhesion molecule	Mus musculus	72-76
31275424-6	2019	The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets.	alpha-terpineol	110-129	adrenoceptor beta 2	Homo sapiens	162-167
31275424-6	2019	The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets.	alpha-terpineol	110-129	dopamine receptor D2	Homo sapiens	169-173
32131591-7	2020	e-Fold times, tau1/e, in water-rich solvent mixtures range from tau1/e = 15-45 min for monoterpene-derived alpha-HHs to tau1/e > 103 min for the alpha-Tp-derived alpha-HH.	alpha-terpineol	145-153	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	107-115
32131591-9	2020	Decay rates of the alpha-Tp-derived alpha-HH in pure water increase at lower pH (2.3 <= pH <= 3.3).	alpha-terpineol	19-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	36-44
32133063-12	2019	In addition, alpha-terpineol (25, 50 and 100 mg/kg) significantly decreased the number of Iba1-positive cells and diminished the concentration of IL-1beta and TNF-alpha in the spinal tissue.	alpha-terpineol	13-28	allograft inflammatory factor 1	Rattus norvegicus	90-94
32133063-12	2019	In addition, alpha-terpineol (25, 50 and 100 mg/kg) significantly decreased the number of Iba1-positive cells and diminished the concentration of IL-1beta and TNF-alpha in the spinal tissue.	alpha-terpineol	13-28	interleukin 1 alpha	Rattus norvegicus	146-154
32133063-12	2019	In addition, alpha-terpineol (25, 50 and 100 mg/kg) significantly decreased the number of Iba1-positive cells and diminished the concentration of IL-1beta and TNF-alpha in the spinal tissue.	alpha-terpineol	13-28	tumor necrosis factor	Rattus norvegicus	159-168
31547812-4	2019	The alpha-Terpineol titer was increased to 0.83 mg/L with overexpression of the rate-limiting genes tHMG1, IDI1 and ERG20F96W-N127W.	alpha-terpineol	4-19	isopentenyl-diphosphate delta-isomerase IDI1	Saccharomyces cerevisiae S288C	107-111
31547812-7	2019	Therefore, ERG9 was overexpressed and the alpha-Terpineol titer was further increased to 3.32 mg/L.	alpha-terpineol	42-57	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	11-15
31275424-6	2019	The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets.	alpha-terpineol	110-129	estrogen receptor 1	Homo sapiens	175-179
31275424-6	2019	The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets.	alpha-terpineol	110-129	potassium voltage-gated channel subfamily H member 2	Homo sapiens	181-186
31275424-6	2019	The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets.	alpha-terpineol	110-129	nuclear receptor subfamily 1 group H member 4	Homo sapiens	188-193
31275424-6	2019	The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets.	alpha-terpineol	110-129	nuclear receptor subfamily 1 group I member 2	Homo sapiens	195-200
31275424-6	2019	The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets.	alpha-terpineol	110-129	nuclear receptor subfamily 1 group I member 3	Homo sapiens	202-207
31275424-6	2019	The results of molecular docking showed that linalool, caryophyllene, dibutyl phthalate, (-)-4-terpineol, and (-)-alpha-terpineol have good binding activity with ADRB2, DRD2, ESR1, KCNH2, NR1H4, NR1I2, NR1I3, and TRPV1 targets.	alpha-terpineol	110-129	transient receptor potential cation channel subfamily V member 1	Homo sapiens	213-218
30540974-11	2019	alpha-TPN also reduced fluid formation and loss of Cl- ions, by interacting directly with GM1 receptors and cholera toxin, thus increasing the uptake of intestinal fluids.	alpha-terpineol	0-9	coenzyme Q10A	Mus musculus	90-93
30540974-12	2019	The results suggest an anti-diarrheal activity of alpha-TPN due to its anticholinergic action, ability to block PGE2 and GM1 receptors and interaction with cholera toxin in secretory diarrhea, making it a promising candidate drug for the treatment of diarrheal diseases.	alpha-terpineol	50-59	coenzyme Q10A	Mus musculus	121-124
30187618-4	2018	The assessment of the main volatiles revealed alpha-terpineol as the principal antibacterial agent (MIC, 78.6-149.7 mug mL-1 ).	alpha-terpineol	46-61	L1 cell adhesion molecule	Mus musculus	120-124
30187618-6	2018	alpha-Terpineol (LC50 , 32.4-75.9 mug mL-1 ) exhibited the strongest antiproliferative effect on these cancer cell lines (LC50 , 22.4-48.1 mug mL-1 ).	alpha-terpineol	0-15	L1 cell adhesion molecule	Mus musculus	38-42
30187618-6	2018	alpha-Terpineol (LC50 , 32.4-75.9 mug mL-1 ) exhibited the strongest antiproliferative effect on these cancer cell lines (LC50 , 22.4-48.1 mug mL-1 ).	alpha-terpineol	0-15	L1 cell adhesion molecule	Mus musculus	143-147
29902782-4	2018	Furthermore, overexpression of COQ1 in the same genetic context but with a mutated farnesyl pyrophosphate synthetase (erg20 mutation K197E), results in statistically significant higher levels of linalool (above 750 mug/L), geraniol, alpha-terpineol, and the sesquiterpenes, farnesol and nerolidol (total concentration of volatile isoprenoids surpasses 1300 mug/L).	alpha-terpineol	233-248	trans-hexaprenyltranstransferase	Saccharomyces cerevisiae S288C	31-35
24947163-0	2014	Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1beta, IL-6 and IL-10 on human macrophages.	alpha-terpineol	18-33	interleukin 1 beta	Homo sapiens	86-94
28899502-12	2017	RESULTS: In alpha-melanocyte-stimulating hormone (alpha-MSH)-stimulated murine B16 melanoma cells, MQ-EO, 1,8-cineole, alpha-pinene, and alpha-terpineol significantly reduced melanin content and tyrosinase activity.	alpha-terpineol	137-152	pro-opiomelanocortin-alpha	Mus musculus	12-48
28899502-16	2017	These results showed that MQ-EO and its main components, 1,8-cineole, alpha-pinene, and alpha-terpineol, possessed potent anti-tyrosinase and anti-melanogenic activities besides the antioxidant properties.	alpha-terpineol	88-103	tyrosinase	Mus musculus	127-137
26912260-6	2016	We deorphanize Or69a, showing a broad response spectrum with the best ligands including 3-hydroxyhexanoate, alpha-terpineol, 3-octanol and linalool.	alpha-terpineol	108-123	Odorant receptor 69a	Drosophila melanogaster	15-20
26146083-3	2015	Nevertheless, carvacrol and alpha-terpineol activated VdTRPA1L but not a honey bee noxious-stimuli-sensitive TRPA, AmHsTRPA, and Drosophila melanogaster TRPA1.	alpha-terpineol	28-43	Transient receptor potential cation channel A1	Drosophila melanogaster	56-61
24947163-0	2014	Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1beta, IL-6 and IL-10 on human macrophages.	alpha-terpineol	18-33	interleukin 6	Homo sapiens	96-100
24947163-0	2014	Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1beta, IL-6 and IL-10 on human macrophages.	alpha-terpineol	18-33	interleukin 10	Homo sapiens	105-110
24947163-3	2014	METHODS: The ability of TTO, terpinen-4-ol and alpha-terpineol to modulate the macrophage response to bacterial LPS stimulation was assessed by ELISA for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6 and IL-10 cytokine production and by western blotting for the activation of nuclear factor kappa B (NF-kappaB) and p38 mitogen-activated protein kinase (MAPK) signaling, which are associated with the expression of pro-inflammatory cytokines.	alpha-terpineol	47-62	tumor necrosis factor	Homo sapiens	154-187
24947163-8	2014	CONCLUSION: TTO, terpinen-4-ol and alpha-terpineol can suppress the production of inflammatory mediators in LPS-stimulated human macrophages; this inhibition was mediated by interfering with the NF-kB, p38 or ERK MAPK pathways.	alpha-terpineol	35-50	mitogen-activated protein kinase 14	Homo sapiens	202-205
24987428-5	2014	The sinapic acid-4-O-sulfate, kaempferol, and alpha-terpineol were found to be IKK2 inhibitors and helped prevent COPD occurrence and worsening according to a screening of the traditional Chinese medicine (TCM) database.	alpha-terpineol	46-61	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	79-83
24987428-5	2014	The sinapic acid-4-O-sulfate, kaempferol, and alpha-terpineol were found to be IKK2 inhibitors and helped prevent COPD occurrence and worsening according to a screening of the traditional Chinese medicine (TCM) database.	alpha-terpineol	46-61	COPD	Homo sapiens	114-118
23025190-6	2012	An in vitro bioassay using female fly heads indicates that strong AChE inhibition was produced by citronellyl acetate, alpha-pinene, thymol, carvacrol, and alpha-terpineol (1.20-2.73 mM), but no direct correlation between fly toxicity and AChE inhibition by the test compounds was observed.	alpha-terpineol	156-171	Acetylcholine esterase	Drosophila melanogaster	66-70
23274539-3	2013	The present study showed that alpha-terpineol induces fatty liver via the AMP-activated protein kinase (AMPK)-mTOR-sterol regulatory element-binding protein-1 (SREBP-1) pathway.	alpha-terpineol	30-45	mechanistic target of rapamycin kinase	Mus musculus	110-114
23274539-3	2013	The present study showed that alpha-terpineol induces fatty liver via the AMP-activated protein kinase (AMPK)-mTOR-sterol regulatory element-binding protein-1 (SREBP-1) pathway.	alpha-terpineol	30-45	sterol regulatory element binding transcription factor 1	Mus musculus	160-167
23274539-5	2013	alpha-Terpineol suppressed AMPK phosphorylation, and increased p70S6 kinase (p70S6K) phosphorylation and SREBP-1 activation.	alpha-terpineol	0-15	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	63-75
23274539-5	2013	alpha-Terpineol suppressed AMPK phosphorylation, and increased p70S6 kinase (p70S6K) phosphorylation and SREBP-1 activation.	alpha-terpineol	0-15	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	77-83
23274539-5	2013	alpha-Terpineol suppressed AMPK phosphorylation, and increased p70S6 kinase (p70S6K) phosphorylation and SREBP-1 activation.	alpha-terpineol	0-15	sterol regulatory element binding transcription factor 1	Mus musculus	105-112
23274539-7	2013	Inhibition of mTOR signaling by co-treatment with rapamycin or co-transfection with dominant negative p70S6K blocked completely the effects of alpha-terpineol.	alpha-terpineol	143-158	mechanistic target of rapamycin kinase	Mus musculus	14-18
23274539-7	2013	Inhibition of mTOR signaling by co-treatment with rapamycin or co-transfection with dominant negative p70S6K blocked completely the effects of alpha-terpineol.	alpha-terpineol	143-158	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	102-108
23274539-8	2013	alpha-Terpineol oral administration to mice for 2weeks led to decreased AMPK phosphorylation and increased SREBP-1 activation in the liver, followed by hepatic lipid accumulation.	alpha-terpineol	0-15	sterol regulatory element binding transcription factor 1	Mus musculus	107-114
23274539-9	2013	Conversely, rapamycin co-treatment reversed alpha-terpineol-induced SREBP-1 activation and fatty liver in mice.	alpha-terpineol	44-59	sterol regulatory element binding transcription factor 1	Mus musculus	68-75
23274539-10	2013	These data provide evidence that alpha-terpineol causes fatty liver, an effect mediated by the AMPK/mTOR/SREBP-1 pathway.	alpha-terpineol	33-48	mechanistic target of rapamycin kinase	Mus musculus	100-104
23274539-10	2013	These data provide evidence that alpha-terpineol causes fatty liver, an effect mediated by the AMPK/mTOR/SREBP-1 pathway.	alpha-terpineol	33-48	sterol regulatory element binding transcription factor 1	Mus musculus	105-112
23200656-6	2013	We demonstrated both by gene overexpression and gene-deletion the involvement of ATF1 enzyme but not ATF2 in the acetylation of terpenols.	alpha-terpineol	128-137	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	81-85
23200656-7	2013	The affinity of ATF1 enzyme for several terpenols and for isoamyl alcohol was compared.	alpha-terpineol	40-49	alcohol O-acetyltransferase	Saccharomyces cerevisiae S288C	16-20
21830186-9	2011	In addition, they inhibited the expressions of proinflammatory cytokines and the activation of NF- kappaB in lipopolysaccharide-stimulated peritoneal macrophages, and alpha-terpineol most potently inhibited the expressions of proinflammatory cytokines and NF- kappaB activation.	alpha-terpineol	167-182	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-105
21830186-9	2011	In addition, they inhibited the expressions of proinflammatory cytokines and the activation of NF- kappaB in lipopolysaccharide-stimulated peritoneal macrophages, and alpha-terpineol most potently inhibited the expressions of proinflammatory cytokines and NF- kappaB activation.	alpha-terpineol	167-182	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	256-266
21830186-10	2011	Based on these findings, APEO and its constituents, particularly alpha-terpineol, ameliorate bacterial vaginosis and vulvovaginal candidiasis by inhibiting the growths of vaginal pathogens and the activation of NF- kappaB.	alpha-terpineol	65-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	211-221