PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25596530-0	2015	Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mTOR)-independent autophagy.	Conophylline	0-12	mechanistic target of rapamycin kinase	Homo sapiens	89-118
26801823-2	2016	Here, we developed an effective method with activin A, conophylline, and nicotinamide to induce mouse bMSCs to differentiate into insulin-producing cells (IPCs).	Conophylline	55-67	insulin	Homo sapiens	130-137
25596530-0	2015	Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mTOR)-independent autophagy.	Conophylline	0-12	mechanistic target of rapamycin kinase	Homo sapiens	120-124
25596530-3	2015	Here, we show that conophylline (CNP), a vinca alkaloid, induces autophagy in an mammalian target of rapamycin-independent manner.	Conophylline	19-31	mechanistic target of rapamycin kinase	Homo sapiens	81-110
25596530-3	2015	Here, we show that conophylline (CNP), a vinca alkaloid, induces autophagy in an mammalian target of rapamycin-independent manner.	Conophylline	33-36	mechanistic target of rapamycin kinase	Homo sapiens	81-110
14625694-1	2003	In the course of screening for inhibitors of transforming-growth factor-beta (TGF-beta) functions we found that conophylline, a vinca alkaloid, inhibited TGF-beta-induced apoptosis in rat hepatoma cells.	Conophylline	112-124	transforming growth factor, beta 1	Rattus norvegicus	78-86
24792671-0	2014	Inhibition of receptor activator of nuclear factor-kappaB ligand- or lipopolysaccharide-induced osteoclast formation by conophylline through downregulation of CREB.	Conophylline	120-132	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	14-64
24792671-0	2014	Inhibition of receptor activator of nuclear factor-kappaB ligand- or lipopolysaccharide-induced osteoclast formation by conophylline through downregulation of CREB.	Conophylline	120-132	cAMP responsive element binding protein 1	Mus musculus	159-163
24792671-1	2014	The effect of conophylline (CNP) on the receptor activator of nuclear factor-kappaB ligand (RANKL) or lipopolysaccharide (LPS)-induced osteoclast formation was studied in vitro using bone marrow-derived macrophages (BMMs) or the mouse macrophage-like cell line RAW 264.7.	Conophylline	14-26	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	40-90
24792671-1	2014	The effect of conophylline (CNP) on the receptor activator of nuclear factor-kappaB ligand (RANKL) or lipopolysaccharide (LPS)-induced osteoclast formation was studied in vitro using bone marrow-derived macrophages (BMMs) or the mouse macrophage-like cell line RAW 264.7.	Conophylline	14-26	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	92-97
16337165-5	2006	Conophylline reproduces the differentiation-inducing activity of activin A.	Conophylline	0-12	inhibin subunit beta A	Rattus norvegicus	65-74
16337165-7	2006	To induce differentiation of AR42J cells, conophylline increases the expression of neurogenin-3 by activating p38 mitogen-activated protein kinase.	Conophylline	42-54	neurogenin 3	Rattus norvegicus	83-95
24792671-1	2014	The effect of conophylline (CNP) on the receptor activator of nuclear factor-kappaB ligand (RANKL) or lipopolysaccharide (LPS)-induced osteoclast formation was studied in vitro using bone marrow-derived macrophages (BMMs) or the mouse macrophage-like cell line RAW 264.7.	Conophylline	28-31	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	40-90
24076029-0	2013	Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline.	Conophylline	122-134	ADP ribosylation factor like GTPase 6 interacting protein 1	Homo sapiens	42-49
24076029-0	2013	Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline.	Conophylline	122-134	ADP ribosylation factor like GTPase 6 interacting protein 1	Homo sapiens	110-117
20079600-2	2010	In the present research, we looked into the effect of conophylline on the differentiation of newborn pig pancreatic endocrine cells into insulin-secreting cells.	Conophylline	54-66	insulin	Sus scrofa	137-144
20079600-3	2010	Conophylline potentiated the differentiation of monolayer cells into insulin-producing cells in the presence of nicotinamide in 3 weeks.	Conophylline	0-12	insulin	Sus scrofa	69-76
19679484-1	2009	Conophylline, a vinca alkaloid extracted from the tropical plant Ervatamia microphylla, has been shown to induce the differentiation of insulin-producing beta-cells in cultured cells and in animals.	Conophylline	0-12	insulin	Homo sapiens	136-143
19679484-4	2009	With these conophylline-linked nano-beads, we found that conophylline directly interacted with ARL6IP.	Conophylline	11-23	ADP ribosylation factor like GTPase 6 interacting protein 1	Homo sapiens	95-101
19679484-4	2009	With these conophylline-linked nano-beads, we found that conophylline directly interacted with ARL6IP.	Conophylline	57-69	ADP ribosylation factor like GTPase 6 interacting protein 1	Homo sapiens	95-101
14625694-1	2003	In the course of screening for inhibitors of transforming-growth factor-beta (TGF-beta) functions we found that conophylline, a vinca alkaloid, inhibited TGF-beta-induced apoptosis in rat hepatoma cells.	Conophylline	112-124	transforming growth factor, beta 1	Rattus norvegicus	154-162
14625694-2	2003	Because conophylline also inhibited TGF-b-induced promoter activity in mink lung cells, we studied the mechanism of the inhibition in this cell line.	Conophylline	8-20	transforming growth factor, beta 1	Rattus norvegicus	36-41
14625694-4	2003	Instead, we found that conophylline increased the expression of c-Jun, which had been earlier shown to interact with the corepressor TGIF to suppress the transcriptional activity dependent on Smad2.	Conophylline	23-35	TGFB-induced factor homeobox 1	Rattus norvegicus	133-137
14625694-4	2003	Instead, we found that conophylline increased the expression of c-Jun, which had been earlier shown to interact with the corepressor TGIF to suppress the transcriptional activity dependent on Smad2.	Conophylline	23-35	SMAD family member 2	Rattus norvegicus	192-197
14625694-5	2003	Conophylline attenuated the interaction between the Smad2 complex and p300 but enhanced that between the Smad2 complex and TGIF.	Conophylline	0-12	SMAD family member 2	Rattus norvegicus	52-57
14625694-5	2003	Conophylline attenuated the interaction between the Smad2 complex and p300 but enhanced that between the Smad2 complex and TGIF.	Conophylline	0-12	SMAD family member 2	Rattus norvegicus	105-110
14625694-5	2003	Conophylline attenuated the interaction between the Smad2 complex and p300 but enhanced that between the Smad2 complex and TGIF.	Conophylline	0-12	TGFB-induced factor homeobox 1	Rattus norvegicus	123-127
14625694-7	2003	Thus, our data suggest that inhibition of TGF-beta-induced promoter activity by conophylline can be attributed to its potency in modulating the interaction of downstream transcriptional factors via upregulation of c-Jun expression.	Conophylline	80-92	transforming growth factor, beta 1	Rattus norvegicus	42-50
14568228-4	2003	As a result, a vinca alkaloid, conophylline, induced neurite formation at 0.1 approximately 0.3 microg/ml in 72 h, like activin A.	Conophylline	31-43	inhibin subunit beta A	Rattus norvegicus	120-129
14532979-1	2003	In the course of our screening for tumor necrosis factor-alpha (TNF-alpha) function inhibitors, conophylline, a vinca alkaloid isolated from the plant Ervatamia microphylla, was found to inhibit TNF-alpha-induced NF-kappaB activation.	Conophylline	96-108	tumor necrosis factor	Homo sapiens	35-62
14532979-1	2003	In the course of our screening for tumor necrosis factor-alpha (TNF-alpha) function inhibitors, conophylline, a vinca alkaloid isolated from the plant Ervatamia microphylla, was found to inhibit TNF-alpha-induced NF-kappaB activation.	Conophylline	96-108	tumor necrosis factor	Homo sapiens	64-73
14532979-1	2003	In the course of our screening for tumor necrosis factor-alpha (TNF-alpha) function inhibitors, conophylline, a vinca alkaloid isolated from the plant Ervatamia microphylla, was found to inhibit TNF-alpha-induced NF-kappaB activation.	Conophylline	96-108	tumor necrosis factor	Homo sapiens	195-204
14532979-2	2003	We studied the effect of conophylline on TNF-alpha-induced NF-kappaB and JNK activations in human T-cell leukemia Jurkat cells.	Conophylline	25-37	tumor necrosis factor	Homo sapiens	41-50
14532979-2	2003	We studied the effect of conophylline on TNF-alpha-induced NF-kappaB and JNK activations in human T-cell leukemia Jurkat cells.	Conophylline	25-37	mitogen-activated protein kinase 8	Homo sapiens	73-76
14532979-3	2003	Conophylline inhibited both of these TNF-alpha-induced activations.	Conophylline	0-12	tumor necrosis factor	Homo sapiens	37-46
14532979-7	2003	FACS analysis showed that conophylline reduced the expression of CD120a/TNFR1, the high-affinity receptor for TNF-alpha, on the cell surface.	Conophylline	26-38	TNF receptor superfamily member 1A	Homo sapiens	65-71
14532979-7	2003	FACS analysis showed that conophylline reduced the expression of CD120a/TNFR1, the high-affinity receptor for TNF-alpha, on the cell surface.	Conophylline	26-38	TNF receptor superfamily member 1A	Homo sapiens	72-77
14532979-7	2003	FACS analysis showed that conophylline reduced the expression of CD120a/TNFR1, the high-affinity receptor for TNF-alpha, on the cell surface.	Conophylline	26-38	tumor necrosis factor	Homo sapiens	110-119
14532979-9	2003	These results indicate that conophylline down-regulates the expression of the TNF-alpha receptors on the cell surface.	Conophylline	28-40	tumor necrosis factor	Homo sapiens	78-87
14568228-6	2003	By RT-PCR analysis, conophylline-treated cells were shown to express neurogenin3 strongly.	Conophylline	20-32	neurogenin 3	Rattus norvegicus	69-80
14568228-10	2003	Pretreatment with a p38-specific inhibitor, SB203580, lowered the conophylline-induced insulin production.	Conophylline	66-78	mitogen activated protein kinase 14	Rattus norvegicus	20-23
9464633-4	1997	A phosphatase inhibitor, okadaic acid, and Ras inhibitors such as oxanosine, damnacanthal and conophylline strongly suppressed the effect of GDNF.	Conophylline	94-106	glial cell derived neurotrophic factor	Homo sapiens	141-145
30377255-8	2018	However, conophylline substantially inhibited phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), suggesting that conophylline inhibits HAS2 expression via TGFbeta-mediated activation of the ERK1/2 pathway.	Conophylline	9-21	mitogen-activated protein kinase 1	Homo sapiens	65-106
8879977-0	1996	Growth inhibition of K-ras-expressing tumours by a new vinca alkaloid, conophylline, in nude mice.	Conophylline	71-83	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	21-26
8879977-1	1996	Conophylline, a new vinca alkaloid isolated from the plant Ervatamia microphylla induced normal flat morphology in K-ras-NRK and K-ras-NIH cell lines, and lowered the increased uptake of 2-deoxyglucose in K-ras-NRK cells.	Conophylline	0-12	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	115-120
8879977-1	1996	Conophylline, a new vinca alkaloid isolated from the plant Ervatamia microphylla induced normal flat morphology in K-ras-NRK and K-ras-NIH cell lines, and lowered the increased uptake of 2-deoxyglucose in K-ras-NRK cells.	Conophylline	0-12	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	129-134
8879977-1	1996	Conophylline, a new vinca alkaloid isolated from the plant Ervatamia microphylla induced normal flat morphology in K-ras-NRK and K-ras-NIH cell lines, and lowered the increased uptake of 2-deoxyglucose in K-ras-NRK cells.	Conophylline	0-12	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	129-134
8879977-2	1996	Conophylline inhibited the growth of K-ras-NRK cells, but this inhibition was reversible.	Conophylline	0-12	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	37-42
34127539-0	2021	Thermal proteome profiling reveals GPX4 as the target of the autophagy inducer conophylline.	Conophylline	79-91	glutathione peroxidase 4	Homo sapiens	35-39
34127539-11	2021	Significance Statement In the present study, we identified glutathione peroxidase 4 (GPX4) as a binding protein of conophylline (CNP) by using thermal proteome profiling (TPP).We showed that CNP treatment, similarly with the inhibition of GPX4, induced lipid ROS accumulation and autophagy.	Conophylline	115-127	glutathione peroxidase 4	Homo sapiens	59-83
34127539-11	2021	Significance Statement In the present study, we identified glutathione peroxidase 4 (GPX4) as a binding protein of conophylline (CNP) by using thermal proteome profiling (TPP).We showed that CNP treatment, similarly with the inhibition of GPX4, induced lipid ROS accumulation and autophagy.	Conophylline	115-127	glutathione peroxidase 4	Homo sapiens	85-89
34127539-11	2021	Significance Statement In the present study, we identified glutathione peroxidase 4 (GPX4) as a binding protein of conophylline (CNP) by using thermal proteome profiling (TPP).We showed that CNP treatment, similarly with the inhibition of GPX4, induced lipid ROS accumulation and autophagy.	Conophylline	129-132	glutathione peroxidase 4	Homo sapiens	59-83
34127539-11	2021	Significance Statement In the present study, we identified glutathione peroxidase 4 (GPX4) as a binding protein of conophylline (CNP) by using thermal proteome profiling (TPP).We showed that CNP treatment, similarly with the inhibition of GPX4, induced lipid ROS accumulation and autophagy.	Conophylline	129-132	glutathione peroxidase 4	Homo sapiens	85-89
34127539-11	2021	Significance Statement In the present study, we identified glutathione peroxidase 4 (GPX4) as a binding protein of conophylline (CNP) by using thermal proteome profiling (TPP).We showed that CNP treatment, similarly with the inhibition of GPX4, induced lipid ROS accumulation and autophagy.	Conophylline	191-194	glutathione peroxidase 4	Homo sapiens	59-83
34127539-11	2021	Significance Statement In the present study, we identified glutathione peroxidase 4 (GPX4) as a binding protein of conophylline (CNP) by using thermal proteome profiling (TPP).We showed that CNP treatment, similarly with the inhibition of GPX4, induced lipid ROS accumulation and autophagy.	Conophylline	191-194	glutathione peroxidase 4	Homo sapiens	85-89
34347973-5	2021	Conophylline induced flat morphology and inhibited cellular invasion in K-Ras-transformed normal rat kidney (K-Ras-NRK) cells.	Conophylline	0-12	KRAS proto-oncogene, GTPase	Rattus norvegicus	72-77
33722852-0	2021	Conophylline inhibits hepatocellular carcinoma by inhibiting activated cancer-associated fibroblasts through suppression of G Protein-Coupled Receptor 68.	Conophylline	0-12	G protein-coupled receptor 68	Rattus norvegicus	124-153
30377255-8	2018	However, conophylline substantially inhibited phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), suggesting that conophylline inhibits HAS2 expression via TGFbeta-mediated activation of the ERK1/2 pathway.	Conophylline	9-21	mitogen-activated protein kinase 3	Homo sapiens	108-114
30377255-8	2018	However, conophylline substantially inhibited phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), suggesting that conophylline inhibits HAS2 expression via TGFbeta-mediated activation of the ERK1/2 pathway.	Conophylline	133-145	mitogen-activated protein kinase 1	Homo sapiens	65-106
30377255-8	2018	However, conophylline substantially inhibited phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), suggesting that conophylline inhibits HAS2 expression via TGFbeta-mediated activation of the ERK1/2 pathway.	Conophylline	133-145	mitogen-activated protein kinase 3	Homo sapiens	108-114
30377255-8	2018	However, conophylline substantially inhibited phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), suggesting that conophylline inhibits HAS2 expression via TGFbeta-mediated activation of the ERK1/2 pathway.	Conophylline	133-145	hyaluronan synthase 2	Homo sapiens	155-159
30377255-8	2018	However, conophylline substantially inhibited phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), suggesting that conophylline inhibits HAS2 expression via TGFbeta-mediated activation of the ERK1/2 pathway.	Conophylline	133-145	transforming growth factor beta 1	Homo sapiens	175-182
30377255-8	2018	However, conophylline substantially inhibited phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), suggesting that conophylline inhibits HAS2 expression via TGFbeta-mediated activation of the ERK1/2 pathway.	Conophylline	133-145	mitogen-activated protein kinase 3	Homo sapiens	210-216
8615670-2	1996	Conophylline, a new vinca alkaloid isolated as a ras function inhibitor, inhibited the invasion of K-ras-NIH3T3 cells, while it showed no effect on NIH3T3 cells.	Conophylline	0-12	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	99-104
8615670-3	1996	Conophylline did not increase expression of fibronectin but induced E-cadherin expression in K-ras-NIH3T3 cells.	Conophylline	0-12	cadherin 1	Mus musculus	68-78
8615670-3	1996	Conophylline did not increase expression of fibronectin but induced E-cadherin expression in K-ras-NIH3T3 cells.	Conophylline	0-12	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	93-98
34302205-0	2021	Conophylline Suppresses Angiotensin II-Induced Myocardial Fibrosis In Vitro via the BMP4/JNK Pathway.	Conophylline	0-12	angiotensinogen	Rattus norvegicus	24-38
34302205-0	2021	Conophylline Suppresses Angiotensin II-Induced Myocardial Fibrosis In Vitro via the BMP4/JNK Pathway.	Conophylline	0-12	bone morphogenetic protein 4	Rattus norvegicus	84-88
34302205-0	2021	Conophylline Suppresses Angiotensin II-Induced Myocardial Fibrosis In Vitro via the BMP4/JNK Pathway.	Conophylline	0-12	mitogen-activated protein kinase 8	Rattus norvegicus	89-92
34302205-3	2021	Conophylline markedly protected the cultured cells against the development of angiotensin II-induced fibrosis, which was seen from reduced viability of fibroblasts, decreased collagen content, and down-regulation of the expression of alpha-smooth muscle actin (alpha-SMA).	Conophylline	0-12	angiotensinogen	Rattus norvegicus	78-92
34302205-3	2021	Conophylline markedly protected the cultured cells against the development of angiotensin II-induced fibrosis, which was seen from reduced viability of fibroblasts, decreased collagen content, and down-regulation of the expression of alpha-smooth muscle actin (alpha-SMA).	Conophylline	0-12	actin gamma 2, smooth muscle	Rattus norvegicus	234-259
34302205-4	2021	Conophylline did not affect the TGF-beta pathway altered by angiotensin II, but markedly decreased the level of bone morphogenetic protein-4 (BMP4) enhanced by angiotensin II and BMP4 itself.	Conophylline	0-12	bone morphogenetic protein 4	Rattus norvegicus	112-140
34302205-4	2021	Conophylline did not affect the TGF-beta pathway altered by angiotensin II, but markedly decreased the level of bone morphogenetic protein-4 (BMP4) enhanced by angiotensin II and BMP4 itself.	Conophylline	0-12	bone morphogenetic protein 4	Rattus norvegicus	142-146
34302205-4	2021	Conophylline did not affect the TGF-beta pathway altered by angiotensin II, but markedly decreased the level of bone morphogenetic protein-4 (BMP4) enhanced by angiotensin II and BMP4 itself.	Conophylline	0-12	angiotensinogen	Rattus norvegicus	160-174
34302205-4	2021	Conophylline did not affect the TGF-beta pathway altered by angiotensin II, but markedly decreased the level of bone morphogenetic protein-4 (BMP4) enhanced by angiotensin II and BMP4 itself.	Conophylline	0-12	bone morphogenetic protein 4	Rattus norvegicus	179-183
34302205-5	2021	Conophylline produced no effect on phosphorylation of alpha-SMA and Smad homologue-1/5/8, the classic BMP4 downstream pathway elements, but reduced the level of c-Jun N-terminal kinase (JNK) elevated by BMP4.	Conophylline	0-12	mitogen-activated protein kinase 8	Rattus norvegicus	161-184
34302205-5	2021	Conophylline produced no effect on phosphorylation of alpha-SMA and Smad homologue-1/5/8, the classic BMP4 downstream pathway elements, but reduced the level of c-Jun N-terminal kinase (JNK) elevated by BMP4.	Conophylline	0-12	mitogen-activated protein kinase 8	Rattus norvegicus	186-189
34302205-5	2021	Conophylline produced no effect on phosphorylation of alpha-SMA and Smad homologue-1/5/8, the classic BMP4 downstream pathway elements, but reduced the level of c-Jun N-terminal kinase (JNK) elevated by BMP4.	Conophylline	0-12	bone morphogenetic protein 4	Rattus norvegicus	203-207
34302205-7	2021	Thus, conophylline inhibited angiotensin II-provoked myocardial fibrosis via the BMP4/JNK pathway.	Conophylline	6-18	angiotensinogen	Rattus norvegicus	29-43
34302205-7	2021	Thus, conophylline inhibited angiotensin II-provoked myocardial fibrosis via the BMP4/JNK pathway.	Conophylline	6-18	bone morphogenetic protein 4	Rattus norvegicus	81-85
34302205-7	2021	Thus, conophylline inhibited angiotensin II-provoked myocardial fibrosis via the BMP4/JNK pathway.	Conophylline	6-18	mitogen-activated protein kinase 8	Rattus norvegicus	86-89