PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27451257-0	2016	Multifunctional diamine AGE/ALE inhibitors with potential therapeutical properties against Alzheimer"s disease.	Diamines	16-23	renin binding protein	Homo sapiens	24-27
27128174-2	2016	Several monomeric and dimeric PEGylated compounds have also been produced by linking one diamine-PEG reagent to the carboxyl group at C-28 of the same natural triterpenes and also to their corresponding C-2 or C-2/C-3 acetylated derivatives.	Diamines	89-96	complement C2	Homo sapiens	134-137
27128174-2	2016	Several monomeric and dimeric PEGylated compounds have also been produced by linking one diamine-PEG reagent to the carboxyl group at C-28 of the same natural triterpenes and also to their corresponding C-2 or C-2/C-3 acetylated derivatives.	Diamines	89-96	complement C2	Homo sapiens	210-217
26512870-2	2016	The amide formation reaction of with 1,10-diaminodecane and polyallylamine gave the diamine-bridged dinuclear Rh(III) complex and the single-chain polymer-supported Rh(III) complex with retention of the DeltaL configuration of , respectively.	Diamines	84-91	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	168-171
26905725-3	2016	Arabidopsis spermine (Spm) synthase (SPMS) gene-deficient mutant was previously shown to be rather resistant to the diamine cadaverine (Cad).	Diamines	116-123	spermidine synthase 3	Arabidopsis thaliana	37-41
26512870-2	2016	The amide formation reaction of with 1,10-diaminodecane and polyallylamine gave the diamine-bridged dinuclear Rh(III) complex and the single-chain polymer-supported Rh(III) complex with retention of the DeltaL configuration of , respectively.	Diamines	84-91	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	113-116
25542266-0	2015	Novel FTS-diamine/cinnamic acid hybrids inhibit tumor cell proliferation and migration and promote apoptosis via blocking Ras-related signaling in vitro.	Diamines	10-17	AKT interacting protein	Homo sapiens	6-9
26093026-1	2015	Tissue polyamine levels are largely determined by the activity of ornithine decarboxylase (ODC, EC 4.1.17), which catalyzes the conversion of ornithine to the diamine putrescine.	Diamines	159-166	ornithine decarboxylase 1	Homo sapiens	66-89
26093026-1	2015	Tissue polyamine levels are largely determined by the activity of ornithine decarboxylase (ODC, EC 4.1.17), which catalyzes the conversion of ornithine to the diamine putrescine.	Diamines	159-166	ornithine decarboxylase 1	Homo sapiens	91-94
25848728-1	2015	(S,S)- and (R,R)-beta,gamma-Bis-substituted PNAs were synthesized from the C-2 symmetric vicinal diamine system embedded in 1,4 dihydroxybutane and 1,4-dimethoxybutane scaffolds.	Diamines	97-104	complement C2	Homo sapiens	75-78
26417984-1	2015	The pore structure of TEMPO-mediated oxidized CNF hydrogels, chemically cross-linked with water-soluble diamines, is studied.	Diamines	104-112	NPHS1 adhesion molecule, nephrin	Homo sapiens	46-49
25768307-1	2015	A pH-responsive hydrogel composed of an aliphatic diamine cross-linked with polyethylene glycol diglycidyl ether (PEGDGE) using a single, rapid polymerisation step has been used to detect glucose by entrapping glucose oxidase (GOx) within its cationic network.	Diamines	50-57	hydroxyacid oxidase 1	Homo sapiens	210-225
25768307-1	2015	A pH-responsive hydrogel composed of an aliphatic diamine cross-linked with polyethylene glycol diglycidyl ether (PEGDGE) using a single, rapid polymerisation step has been used to detect glucose by entrapping glucose oxidase (GOx) within its cationic network.	Diamines	50-57	hydroxyacid oxidase 1	Homo sapiens	227-230
25542266-1	2015	Novel FTS-diamine/cinnamic acid hybrids 7a-f were prepared, and their in vitro biological activities were evaluated.	Diamines	10-17	AKT interacting protein	Homo sapiens	6-9
25530671-4	2015	Using Pb(II) as the metal mediator, spermine was selectively detected as a 40-fold signal enhancement relative to spermidine, putrescine, cadaverine and several other non-biogenic diamines.	Diamines	180-188	submaxillary gland androgen regulated protein 3B	Homo sapiens	6-12
25277067-0	2014	Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.	Diamines	13-20	heat shock protein 90 alpha family class A member 1	Homo sapiens	78-83
23625347-4	2013	The diamine antiprotozoal drug pentamidine (P) acutely inhibits IK1 by plugging the cytoplasmic pore region of the channel.	Diamines	4-11	potassium calcium-activated channel subfamily N member 4	Homo sapiens	64-67
24218586-8	2013	Structure-activity analysis indicates TAAR13c to be a general diamine sensor, with pronounced selectivity for odd chains of medium length.	Diamines	62-69	trace amine associated receptor 13c	Danio rerio	38-45
25188879-2	2014	The chelate-diamine group in the cationic unit facilitates advantageous dissolution of transition-metal salts in the present PIL.	Diamines	12-19	serpin family A member 2 (gene/pseudogene)	Homo sapiens	125-128
25188879-3	2014	The interaction of the copper(II) ion with the chelate-diamine PIL was explored by the addition of copper(II) salts to the PIL, demonstrating competitive complexation between the ligand of the added copper(II) salt and the components of the ionic liquid to the copper(II) ion.	Diamines	55-62	serpin family A member 2 (gene/pseudogene)	Homo sapiens	63-66
25188879-3	2014	The interaction of the copper(II) ion with the chelate-diamine PIL was explored by the addition of copper(II) salts to the PIL, demonstrating competitive complexation between the ligand of the added copper(II) salt and the components of the ionic liquid to the copper(II) ion.	Diamines	55-62	serpin family A member 2 (gene/pseudogene)	Homo sapiens	123-126
24944745-0	2014	Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists.	Diamines	0-7	somatostatin receptor 3	Mus musculus	88-92
23957736-1	2013	Vicinal aziridine-containing diamines have been obtained with high syn-stereoselectivity from readily available aziridine aldehyde dimers in the Petasis borono-Mannich reaction.	Diamines	29-37	synemin	Homo sapiens	67-70
23238973-1	2013	Diamine oxidase (DAO) oxidatively deaminates histamine and other diamines.	Diamines	65-73	amine oxidase copper containing 1	Homo sapiens	0-15
24027999-0	2013	[Adsorption of Cd2+ ions in aqueous by diamine-modified ordered mesoporous SBA-15 particles].	Diamines	39-46	CD2 molecule	Homo sapiens	15-18
24027999-11	2013	The study indicated that the diamine -modified ordered mesoporous material SBA-15 is a potential sorbent which could be used for the aqueous Cd2+ removal.	Diamines	29-36	CD2 molecule	Homo sapiens	141-144
23238973-1	2013	Diamine oxidase (DAO) oxidatively deaminates histamine and other diamines.	Diamines	65-73	amine oxidase copper containing 1	Homo sapiens	17-20
23400041-2	2013	Catalytic results show that the di-amine functionalized K10 montmorillonite exhibits high efficacy for promoting this reaction at room temperature and in the absence of a solvent.	Diamines	32-40	keratin 10	Homo sapiens	56-59
22770990-12	2012	Our results indicate that the novel diamine compounds 3, 6 and 9 inhibit critical pro-inflammatory cytokines and stimulate IL-10, which make them attractive candidate drugs for the treatment of certain inflammatory conditions and cancer.	Diamines	36-43	interleukin 10	Homo sapiens	123-128
23266676-1	2013	In this paper, a diamine ligand of dipyrido[3,2-a:2",3"-c]phenazine (DPPZ) and its corresponding Cu(I) complex with triphenylphosphine (PPh(3)) as the phosphorous ligand are synthesized.	Diamines	17-24	caveolin 1	Homo sapiens	136-142
22770990-0	2012	Novel thalidomide analogues from diamines inhibit pro-inflammatory cytokine production and CD80 expression while enhancing IL-10.	Diamines	33-41	CD80 molecule	Homo sapiens	91-95
22770990-0	2012	Novel thalidomide analogues from diamines inhibit pro-inflammatory cytokine production and CD80 expression while enhancing IL-10.	Diamines	33-41	interleukin 10	Homo sapiens	123-128
22966598-5	2012	Among diamine linkers with different chain lengths (C-4, C-8, and C-12), C-8 diamine (1,8-diaminooctane) produced the maximal PL intensity for QD-bound hydrogels, indicating that C-8 diamine was an optimal cross-linker between hydrogels and QDs with surface carboxylic acid groups.	Diamines	6-13	complement C4A (Rodgers blood group)	Homo sapiens	52-55
22966598-5	2012	Among diamine linkers with different chain lengths (C-4, C-8, and C-12), C-8 diamine (1,8-diaminooctane) produced the maximal PL intensity for QD-bound hydrogels, indicating that C-8 diamine was an optimal cross-linker between hydrogels and QDs with surface carboxylic acid groups.	Diamines	6-13	homeobox C8	Homo sapiens	57-60
22966598-5	2012	Among diamine linkers with different chain lengths (C-4, C-8, and C-12), C-8 diamine (1,8-diaminooctane) produced the maximal PL intensity for QD-bound hydrogels, indicating that C-8 diamine was an optimal cross-linker between hydrogels and QDs with surface carboxylic acid groups.	Diamines	6-13	homeobox C8	Homo sapiens	73-76
22966598-5	2012	Among diamine linkers with different chain lengths (C-4, C-8, and C-12), C-8 diamine (1,8-diaminooctane) produced the maximal PL intensity for QD-bound hydrogels, indicating that C-8 diamine was an optimal cross-linker between hydrogels and QDs with surface carboxylic acid groups.	Diamines	6-13	homeobox C8	Homo sapiens	73-76
22346809-1	2012	In the title compound, [Co(C(16)H(19)N(2)O(2))(2)]NO(3) H(2)O, the Co(III) ion is located on an inversion center and is six-coordinated by two phenolate O atoms and four amino N atoms from two diamine ligands, forming an octa-hedral geometry.	Diamines	193-200	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	67-74
22497557-0	2012	C2-symmetric recyclable organocatalyst for enantioselective Strecker reaction for the synthesis of alpha-amino acid and chiral diamine--an intermediate for APN inhibitor.	Diamines	127-134	alanyl aminopeptidase, membrane	Homo sapiens	156-159
22411760-2	2012	The resulting PANI/SBA-15 is capable of chelating Co(II) ions, presumably via its nitrogen atoms on PANI/diamine groups.	Diamines	105-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
21612250-5	2011	We first describe a method, using long-chain diamines instead of monoamines, for swelling of AMH-3 while preserving its pore structure to a greater extent during the swelling process.	Diamines	45-53	anti-Mullerian hormone	Homo sapiens	93-96
21556397-1	2011	The example of syn-aldol reaction of cyclohexanone to aldehyde was demonstrated based on chiral diamine organocatalysts and it was realized either by increasing the molecular size of acid additives or by introducing a hydrogen-bond donor into acid additives.	Diamines	96-103	synemin	Homo sapiens	15-18
20574850-4	2011	Polycondensates of diethylenetriaminepentaacetic acid (DTPA) with either diols or diamines were synthesised and coupled to the targeting group, a lectin (Lycopersicon esculentum agglutinin, tomato lectin) which binds with high affinity to specific oligosaccharide configurations in the endothelial glycocalyx.	Diamines	82-90	LTL	Solanum lycopersicum	146-152
20930404-6	2010	Benzyl-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)methanamine ligands 3 and 4 belong to the centrally acting diamine-based class of H(3)R antagonist/inverse agonist, whereas kojic acid analogues 6 and 7 might act peripherally.	Diamines	105-112	histamine receptor H3	Homo sapiens	128-133
21232776-1	2011	The pyrrolidine ring of nicotine is derived from the diamine putrescine, which can be synthesized either directly from ornithine via the action of ODC, or from arginine via a three enzymatic step process, initiated by ADC.	Diamines	53-60	ornithine decarboxylase	Nicotiana tabacum	147-150
21280661-3	2011	At low reductant levels, NBS oxidizes Au(I), which linearly suppresses subsequent oxidation of TMB by NBS to its blue charge-transfer complex of diamine and diimine to 2.00 mg L(-1) of Au, resulting in reduced color formation.	Diamines	145-152	nibrin	Homo sapiens	25-28
21280661-3	2011	At low reductant levels, NBS oxidizes Au(I), which linearly suppresses subsequent oxidation of TMB by NBS to its blue charge-transfer complex of diamine and diimine to 2.00 mg L(-1) of Au, resulting in reduced color formation.	Diamines	145-152	nibrin	Homo sapiens	102-105
21264400-1	2011	Chiral primary-tertiary diamine/TfOH was found to catalyze kinetic resolution of racemic syn-aldols of cyclohexanones in ionic liquid effectively, affording the chiral syn-aldols with up to 99:1 syn/anti and 99% ee.	Diamines	24-31	synemin	Homo sapiens	89-92
21264400-1	2011	Chiral primary-tertiary diamine/TfOH was found to catalyze kinetic resolution of racemic syn-aldols of cyclohexanones in ionic liquid effectively, affording the chiral syn-aldols with up to 99:1 syn/anti and 99% ee.	Diamines	24-31	synemin	Homo sapiens	168-171
21264400-1	2011	Chiral primary-tertiary diamine/TfOH was found to catalyze kinetic resolution of racemic syn-aldols of cyclohexanones in ionic liquid effectively, affording the chiral syn-aldols with up to 99:1 syn/anti and 99% ee.	Diamines	24-31	synemin	Homo sapiens	168-171
21204554-2	2011	A PNN pincer ruthenium complex, the Milstein catalyst, was used for this reaction and polyamides with number average molecular weight from ~10 to 30 kDa could be obtained from a wide variety of diols and diamines bearing aliphatic or aromatic, linear or cyclic spacers.	Diamines	204-212	pinin, desmosome associated protein	Homo sapiens	2-5
21050846-1	2011	The simple diamine diaminoethane (ethylenediamine, EDA) has been shown to activate GABA receptors in the central and peripheral nervous systems, partly by a direct action and partly by releasing endogenous GABA.	Diamines	11-18	ectodysplasin-A	Rattus norvegicus	51-54
20358980-6	2010	Especially, the diamine-modified sample has the highest release amount for two proteins, Lysozyme (LYS) and Myoglobin (MYO).	Diamines	16-23	lysozyme	Homo sapiens	89-97
20358980-6	2010	Especially, the diamine-modified sample has the highest release amount for two proteins, Lysozyme (LYS) and Myoglobin (MYO).	Diamines	16-23	lysozyme	Homo sapiens	99-102
20358980-6	2010	Especially, the diamine-modified sample has the highest release amount for two proteins, Lysozyme (LYS) and Myoglobin (MYO).	Diamines	16-23	myoglobin	Homo sapiens	108-117
19690796-1	2010	A series of PTH hybrids containing a diamine [NH(2)(CH(2))(n)NH(2); n = 4, 5, 6] in the C-terminal position was synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) (Har = homoarginine) template.	Diamines	37-44	parathyroid hormone	Homo sapiens	12-15
20188885-3	2010	Surprisingly, ECL intensities of monoamines, such as 2-(dibutylamino)ethanol and N-butyldiethanolamine, are much stronger than that of diamines including N,N,N",N"-tetrakis-(2-hydroxyethyl)-ethylenediamine and N,N,N",N"-tetrakis-(2-hydroxypropyl)ethlenediamine.	Diamines	135-143	C-C motif chemokine ligand 21	Homo sapiens	14-17
20188885-4	2010	The striking contrast between ECL signals of the investigated monoamines and diamines may result from more significant side reactions of diamines, such as the intramolecular side reactions between oxidative amine cation radicals and reductive amine free radicals.	Diamines	137-145	C-C motif chemokine ligand 21	Homo sapiens	30-33
20124708-4	2010	hDAO is unique among CAOs in that it has a distinct substrate preference for diamines.	Diamines	77-85	D-amino acid oxidase	Homo sapiens	0-4
19956999-4	2010	We bring together an analysis of certain metabolic changes, particularly in amino acids, to infer the responsive regulation brought about by increased diamine or polyamine levels in actively growing poplar cell cultures (transformed with mouse ornithine decarboxylase gene to accumulate high Put levels) and ripening tomato pericarp (transformed with yeast S-adenosylmethionine decarboxylase gene to accumulate high Spd and Spm levels at the cost of Put).	Diamines	151-158	ornithine decarboxylase, structural 1	Mus musculus	244-267
19764817-2	2009	The product of the AOC1 gene is a so-called diamine oxidase (hDAO), named for its substrate preference for diamines, particularly histamine.	Diamines	107-115	amine oxidase copper containing 1	Homo sapiens	19-23
19577344-0	2009	Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists.	Diamines	55-62	histamine receptor H3	Homo sapiens	69-90
19764817-2	2009	The product of the AOC1 gene is a so-called diamine oxidase (hDAO), named for its substrate preference for diamines, particularly histamine.	Diamines	107-115	amine oxidase copper containing 1	Homo sapiens	44-59
19764817-2	2009	The product of the AOC1 gene is a so-called diamine oxidase (hDAO), named for its substrate preference for diamines, particularly histamine.	Diamines	107-115	D-amino acid oxidase	Homo sapiens	61-65
19252322-0	2009	Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H(3) receptor antagonists: conformationally restricted derivatives.	Diamines	0-7	histamine receptor H3	Homo sapiens	86-109
19651420-1	2009	Putrescine N-methyltransferase (PMT) catalyses S-adenosylmethionine (SAM) dependent methylation of the diamine putrescine.	Diamines	103-110	putrescine N-methyltransferase 3	Nicotiana tabacum	32-35
19552432-0	2009	Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands.	Diamines	34-41	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	144-149
19524331-0	2009	Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines.	Diamines	0-7	histamine receptor H3	Homo sapiens	20-41
19196547-1	2009	Several diamines with remarkable different polarities were used to produce photoactive poly(amide-imide)s (PAI)s in a quantitative yield.	Diamines	8-16	serpin family E member 1	Homo sapiens	107-110
19252322-1	2009	Novel conformationally restricted diamine derivatives containing imidazolidinylidene propanedinitrile were synthesized and evaluated for human and rat histamine H(3) receptor (H(3)R) binding affinities.	Diamines	34-41	histamine receptor H3	Rattus norvegicus	151-181
18353639-0	2008	Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H3 receptor antagonists.	Diamines	0-7	histamine receptor H3	Homo sapiens	86-107
19441307-4	2009	Method A is a covalent-modification of the s-SWNTs with an acrylic acid (AAc)-photografted Nafion membrane in the presence of a diamine and a condensation reagent.	Diamines	128-135	glycine-N-acyltransferase	Homo sapiens	73-76
19152260-0	2009	Chiral primary-tertiary diamine catalysts derived from natural amino acids for syn-aldol reactions of hydroxy ketones.	Diamines	24-31	synemin	Homo sapiens	79-82
19006313-8	2008	Apparently, the pH-selective membrane destabilization profile of PAsp(DET) corresponded to a protonation change in the flanking diamine unit, i.e., the monoprotonated gauche form at physiological pH and diprotonated anti form at acidic pH.	Diamines	128-135	carboxypeptidase B1	Homo sapiens	65-69
18783804-4	2008	Natural and synthetic diamines, cyclohexylamine, the putrescine analogue 1-aminooxy-3-aminopropane, and several polyamine analogues had inhibitory effects on polyamine oxidase activity and none were substrates.	Diamines	22-30	polyamine oxidase 1	Zea mays	158-175
18660501-1	2008	SLC3A2, a member of the solute carrier family, was identified by proteomics methods as a component of a transporter capable of exporting the diamine putrescine in the Chinese hamster ovary (CHO) cells selected for resistance to growth inhibition by high exogenous concentrations of putrescine.	Diamines	141-148	4F2 cell-surface antigen heavy chain	Cricetulus griseus	0-6
18660501-10	2008	These data provide the first molecular characterization of a polyamine exporter in animal cells and indicate that the diamine putrescine is exported by an arginine transporter containing SLC3A2, whose expression is negatively regulated by K-RAS.	Diamines	118-125	solute carrier family 3 member 2	Homo sapiens	187-193
18660501-10	2008	These data provide the first molecular characterization of a polyamine exporter in animal cells and indicate that the diamine putrescine is exported by an arginine transporter containing SLC3A2, whose expression is negatively regulated by K-RAS.	Diamines	118-125	KRAS proto-oncogene, GTPase	Homo sapiens	239-244
18774940-0	2008	DNA binding studies of PdCl2(LL) (LL = chelating diamine ligand: N,N-dimethyltrimethylenediamine) complex.	Diamines	49-56	phosducin like 2	Bos taurus	23-32
18774940-0	2008	DNA binding studies of PdCl2(LL) (LL = chelating diamine ligand: N,N-dimethyltrimethylenediamine) complex.	Diamines	49-56	phosducin like 2	Bos taurus	29-31
18533688-3	2008	Following on from our studies of the SmI(2)-mediated asymmetric syntheses of alpha,gamma-substituted gamma-butyrolactones, we found that simple homocoupling of chiral N- tert-butanesulfinyl imines in the presence of SmI(2) produced enantiopure vicinal C2-symmetric diamines in high yield.	Diamines	265-273	SM2	Homo sapiens	37-42
18533688-4	2008	In addition, C2-unsymmetric chiral diamines are readily prepared through SmI(2)-mediated cross-couplings of N- tert-butanesulfinyl imines and nitrones; these transformations represented the first successful examples of asymmetric cross-coupling between two different imine species.	Diamines	35-43	SM2	Homo sapiens	73-78
18318476-1	2008	The reduction of prochiral ketones catalyzed by Ru(diphosphine)(diamine) complexes has been studied at the DFT-PBE level of theory.	Diamines	64-71	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	111-114
18324821-3	2008	The (S,S)-diamine is a useful (+)-sparteine surrogate and was utilized in short syntheses of (-)-indolizidine 167B and an intermediate for the synthesis of the CCK antagonist (+)-RP 66803.	Diamines	4-17	cholecystokinin	Homo sapiens	160-163
18353639-2	2008	Novel diamine derivatives containing imidazolidinylidene propanedinitrile were synthesized and evaluated for histamine H(3) receptor-binding affinities.	Diamines	6-13	histamine receptor H3	Homo sapiens	109-132
17439286-1	2007	This paper reports the use of a range of amino acids to construct diverse gelators, employing structures in which Boc-protected amino acids are attached to either end of an aliphatic diamine spacer chain.	Diamines	183-190	BOC cell adhesion associated, oncogene regulated	Homo sapiens	114-117
18249549-6	2008	In general, hydroxyl derivatives derived from more constrained bicyclic diamines exhibited greater selectivity for interaction with DAT compared to the corresponding 3,6-disubstituted diamines.	Diamines	72-80	solute carrier family 6 member 3	Homo sapiens	132-135
17408249-3	2007	We have identified aryl sulfonamides containing a chiral chroman diamine moiety that are potent antagonists of the human B1 receptor.	Diamines	65-72	bradykinin receptor B1	Homo sapiens	121-132
17174363-8	2007	The recombinant MPO1 protein utilized N-methylputrescine more efficiently than other diamines.	Diamines	85-93	copper methylamine oxidase-like	Nicotiana tabacum	16-20
17283012-4	2007	Recombinant MPO protein expressed in Escherichia coli formed a homodimer and deaminated N-methylputrescine more efficiently than symmetrical diamines.	Diamines	141-149	copper methylamine oxidase-like	Nicotiana tabacum	12-15
17268092-0	2007	Thalidomide analogs from diamines: Synthesis and evaluation as inhibitors of TNF-alpha production.	Diamines	25-33	tumor necrosis factor	Homo sapiens	77-86
17123799-3	2007	Deprotonization of the central diamine group is a required condition for micellization, which is an endothermic entropy-driven process owing to hydrophobic interactions between the PPO chains.	Diamines	31-38	protoporphyrinogen oxidase	Homo sapiens	181-184
16492052-0	2006	mu-eta2:eta2-peroxodicopper(II) complex with a secondary diamine ligand: a functional model of tyrosinase.	Diamines	57-64	tyrosinase	Homo sapiens	95-105
17125408-2	2006	The (major) oxidative enzymes, other than CYPs, involved in the metabolism of drugs and other xenobiotics are: the flavin-containing monooxygenases, the molybdenum hydroxylases (aldehyde oxidase and xanthine oxidase), the prostaglandin H synthase, the lipoxygenases, the amine oxidases (monoamine, polyamine, diamine and semicarbazide-sensitive amine oxidases) and the alcohol and aldehyde dehydrogenases.	Diamines	309-316	aldehyde oxidase 1	Homo sapiens	178-194
16278042-1	2006	Diamine oxidase (DAO; EC 1.4.3.6), which catabolizes a variety of substrates including histamine and diamines, is the degradative enzyme of the catabolic pathway of polyamines found in high activity in the mature upper villus cells of the rat intestinal mucosa [Luk, G.D., Bayless, T.M., Baylin, S.B., 1983.	Diamines	101-109	amine oxidase, copper containing 1	Rattus norvegicus	0-15
16267871-0	2006	Catalytic asymmetric mannich-type reactions activated by ZnF2 chiral diamine in aqueous media.	Diamines	69-76	zinc finger protein 2	Homo sapiens	57-61
16267871-7	2006	On the basis of several experimental results, it can be concluded that the reaction mechanism is likely to be a fluoride-catalyzed one, in which the ZnF2 chiral diamine complex is regenerated from the Me3SiF formed during the reaction.	Diamines	161-168	zinc finger protein 2	Homo sapiens	149-153
16278042-1	2006	Diamine oxidase (DAO; EC 1.4.3.6), which catabolizes a variety of substrates including histamine and diamines, is the degradative enzyme of the catabolic pathway of polyamines found in high activity in the mature upper villus cells of the rat intestinal mucosa [Luk, G.D., Bayless, T.M., Baylin, S.B., 1983.	Diamines	101-109	amine oxidase, copper containing 1	Rattus norvegicus	17-20
16316973-5	2005	Using spermine and diamines as polyamine analogs, we demonstrate that both spontaneous and PIP2 antibody-induced rundown of Kir2.1 channels in excised inside-out patches was markedly slowed by long polyamines; in contrast, polyamines with shorter chain length were ineffective.	Diamines	19-27	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	124-130
16277526-5	2005	In sharp contrast, for secondary diamines L with bulk on chelate ring nitrogens (e.g., 2,2"-bipiperidine, Bip), unexpectedly stable duplexes having two platinated strands (even a unique G3,G4/G4,G5 heteroduplex) were formed.	Diamines	33-41	growth differentiation factor 10	Homo sapiens	106-109
15522419-0	2004	Water-soluble platinum(II) complexes of diamine chelating ligands bearing amino-acid type substituents: the effect of the linked amino acid and the diamine chelate ring size on antitumor activity, and interactions with 5"-GMP and DNA.	Diamines	40-47	5'-nucleotidase, cytosolic II	Homo sapiens	222-225
15925515-4	2005	The design of this new compound was carried out using molecular modeling techniques, with the structures of natural polyamines (putrescine, spermidine, and spermine) and biosynthetically related diamines (1,3-diaminopropane; DAP) as templates.	Diamines	195-203	death-associated protein	Rattus norvegicus	225-228
15099103-1	2004	Proton, 13C, 6Li, and 15N NMR line-shape studies of exo,exo-1-trimethylsilyl-3-(dimethylethylsilyl)allyllithium-6Li complexed to [14N,15N]-N,N,N",N"-tetramethylethylenediamine (TMEDA) 2 as a function of temperature and of added diamine reveal the dynamics of three fast equilibrium reorganization processes.	Diamines	168-175	exonuclease 1	Homo sapiens	56-61
15216374-1	2004	[Cr(CO)3(naphthoquinone)](1), prepared in a three-step sequence starting from 1,4-dihydroxynaphthalene, was reduced to the corresponding meso-dihydronaphthalene syn-diol complex and the latter was desymmetrized to give the mono-acyl complex with 99% ee via asymmetric acylation catalyzed by the two new and easily accessed chiral diamines 7 and 8.	Diamines	330-338	synemin	Homo sapiens	161-164
15069073-1	2004	Tissue transglutaminase (TG2) is a ubiquitous enzyme that cross-links glutamine residues with lysine residues, resulting in protein polymerization, cross-linking of dissimilar proteins, and incorporation of diamines and polyamines into proteins.	Diamines	207-215	transglutaminase 2	Homo sapiens	0-23
15134531-3	2004	The resulting PEG bound diamines was N-acylated with 4-fluoro-3-nitrobenzoic acid selectively in primary aromatic amino moiety.	Diamines	24-32	progestagen associated endometrial protein	Homo sapiens	14-17
15307761-2	2004	The new diamines exhibited opposite enantioselectivity to that observed with (-)-sparteine but increasing the steric hindrance of the N-alkyl group beyond N-Et had a detrimental effect on enantioselectivity.	Diamines	8-16	solute carrier family 6 member 2	Homo sapiens	155-159
15147190-5	2004	This diamine- and gadolinium-substituted derivative of Abeta is shown to have enhanced in vitro binding to Alzheimer"s disease (AD) amyloid plaques and increased in vivo permeability at the blood-brain barrier because of the unique Asp/Glu substitutions.	Diamines	5-12	amyloid beta (A4) precursor protein	Mus musculus	55-60
12930154-0	2003	A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines.	Diamines	15-22	histamine receptor H3	Homo sapiens	35-56
15065292-0	2004	A chemically modified platinum electrode as a bidentate diamine ligand for forming well-defined, immobilized bis(eta 1-P-ether phosphane)(diamine)ruthenium(II) complexes.	Diamines	56-63	secreted phosphoprotein 1	Homo sapiens	113-118
15065292-0	2004	A chemically modified platinum electrode as a bidentate diamine ligand for forming well-defined, immobilized bis(eta 1-P-ether phosphane)(diamine)ruthenium(II) complexes.	Diamines	138-145	secreted phosphoprotein 1	Homo sapiens	113-118
14679524-1	2003	The use of a sterically hindered diamine ligand (Me(4)DACH) has allowed for the first time, the isolation and characterization, both in the solid state (X-ray crystallography) and in solution (circular dichroism), of pure DeltaHT rotamers of [Pt(Me(4)dach)(5"-GMP)(2)] (compounds 1 and 2 for R,R and S,S configurations of the Me(4)DACH ligand, respectively).	Diamines	33-40	5'-nucleotidase, cytosolic II	Homo sapiens	260-263
14552906-1	2003	Activation of polyamine catabolism in transgenic mice through an overexpression of spermidine/spermine N(1)-acetyltransferase (SSAT) results in a massive overaccumulation of the diamine putrescine in most tissues including brain.	Diamines	178-185	spermidine/spermine N1-acetyl transferase 1	Mus musculus	83-125
14552906-1	2003	Activation of polyamine catabolism in transgenic mice through an overexpression of spermidine/spermine N(1)-acetyltransferase (SSAT) results in a massive overaccumulation of the diamine putrescine in most tissues including brain.	Diamines	178-185	spermidine/spermine N1-acetyl transferase 1	Mus musculus	127-131
12968867-1	2003	The complexation behavior, binding properties, and spectral parameters of supramolecular chirality induction in the achiral host molecule, syn (face-to-face conformation) ethane-bridged bis(zinc porphyrin), upon interaction with chiral bidentate guests (diamines and amino alcohols) have been studied by means of UV-vis, CD, fluorescence, (1)H NMR, and ESI MS techniques.	Diamines	254-262	synemin	Homo sapiens	139-142
12322753-5	2002	Concentrations of imine nitrogens in the compost spectra suggest that covalent binding by the diamines 2,4DANT and 2,6DANT is a significant process in the transformation of TNT into bound residues.	Diamines	94-102	chromosome 16 open reading frame 82	Homo sapiens	173-176
12467711-1	2003	A series of diamine and polyamine derivatives, either free amines or salts (HCl or TFA), of aspartic and glutamic acid were prepared in excellent yields using Rink Amide solid-phase synthesis.	Diamines	12-19	coagulation factor III, tissue factor	Homo sapiens	83-86
12949871-0	2003	Catalytic asymmetric allylation of hydrazono esters in aqueous media by using ZnF2-chiral diamine.	Diamines	90-97	zinc finger protein 2	Homo sapiens	78-82
15035803-3	2003	In mammals, diamine oxidase has a role in the metabolism of histamine, some other diamines and spermine oxidase, involved in the metabolism of polyamines.	Diamines	82-90	amine oxidase copper containing 1	Homo sapiens	12-27
12182874-0	2002	Long-chain aminoalcohol and diamine derivatives induce apoptosis through a caspase-3 dependent pathway.	Diamines	28-35	caspase 3	Homo sapiens	75-84
12167002-0	2002	A stabilized mu-eta(2):eta(2) peroxodicopper(II) complex with a secondary diamine ligand and its tyrosinase-like reactivity.	Diamines	74-81	tyrosinase	Homo sapiens	97-107
11782178-2	2002	Dimers of general structure (RLi)(2)S(2) (S = chelating diamine) are formed in each case.	Diamines	56-63	ATP binding cassette subfamily E member 1	Homo sapiens	29-32
11909625-1	2002	Putrescine:SAM N-methyltransferase (PMT) catalyses the N-methylation of the diamine putrescine to form N-methylputrescine, the first specific precursor of both tropane and pyridine-type alkaloids, which are present together in the roots of Duboisia plants.	Diamines	76-83	putrescine N-methyltransferase 3	Nicotiana tabacum	36-39
11266164-1	2001	A non-rigid cyclopropane-containing diamine analogue of CP-99,994 was synthesised and was found to have only moderate NK1 receptor binding affinity.	Diamines	36-43	tachykinin receptor 1	Homo sapiens	118-130
11454337-1	2001	Epimerization of aldoses at C-2 has been extensively investigated by using various metal ions in conjunction with diamines, monoamines, and aminoalcohols.	Diamines	114-122	complement C2	Homo sapiens	28-31
11310560-2	2001	Their biosynthetic precursor, the diamine putrescine (PUT), is produced by regulatory ornithine decarboxylase (ODC).	Diamines	34-41	ornithine decarboxylase, structural 1	Mus musculus	86-109
11270424-2	2001	Arginase catalyzes the synthesis of ornithine, the precursor for polyamines from arginine, whereas DAO catalyzes the oxidation of diamines.	Diamines	130-138	amine oxidase copper containing 1	Homo sapiens	99-102
11310560-2	2001	Their biosynthetic precursor, the diamine putrescine (PUT), is produced by regulatory ornithine decarboxylase (ODC).	Diamines	34-41	ornithine decarboxylase, structural 1	Mus musculus	111-114
10987435-2	2000	Several derivatives of aspartic acid, glutamic acid, and lysine exhibited moderate (10-50 microM) affinity for EBP; "dimerization" of the most potent analogues by coupling with linear diamines led to EPO competitors having 1-2 microM binding affinities.	Diamines	184-192	EBP cholestenol delta-isomerase	Homo sapiens	111-114
11098085-6	2000	Using GC7 as a prototype we have synthesized and tested three classes of diamine analogs, namely, guanidino-, pyrimidino-, and hydroxamate derivatives, as potential inhibitors for deoxyhypusine synthase.	Diamines	73-80	deoxyhypusine synthase	Mus musculus	180-202
11055353-2	2000	An indole with basic diamine moieties (12a) was the most potent thrombin inhibitor in the series with Kass= 197 x 10(6) L/mol.	Diamines	21-28	coagulation factor II, thrombin	Homo sapiens	64-72
11055349-1	2000	Functional probing of the backbone of the Sanofi NK2 antagonist SR 48968 has resulted in the discovery of two new classes of NK1/NK2 dual antagonists: the diamine class and the oxime class.	Diamines	155-162	tachykinin receptor 2	Homo sapiens	49-52
11055349-1	2000	Functional probing of the backbone of the Sanofi NK2 antagonist SR 48968 has resulted in the discovery of two new classes of NK1/NK2 dual antagonists: the diamine class and the oxime class.	Diamines	155-162	tachykinin receptor 1	Homo sapiens	125-128
11055349-1	2000	Functional probing of the backbone of the Sanofi NK2 antagonist SR 48968 has resulted in the discovery of two new classes of NK1/NK2 dual antagonists: the diamine class and the oxime class.	Diamines	155-162	tachykinin receptor 2	Homo sapiens	129-132
10987435-2	2000	Several derivatives of aspartic acid, glutamic acid, and lysine exhibited moderate (10-50 microM) affinity for EBP; "dimerization" of the most potent analogues by coupling with linear diamines led to EPO competitors having 1-2 microM binding affinities.	Diamines	184-192	erythropoietin	Homo sapiens	200-203
10080628-2	1999	Diamine derivatives were eluted from capillary gas chromatographic (CGC) column BP1 (12 m x 0.22 mm I.D.)	Diamines	0-7	BP1	Homo sapiens	80-83
10725088-3	2000	The structure of the oligopeptide diamine consisting of glutamic acid and lysine residues was designed as a substrate for cathepsin B, a lysosomal enzyme, which was assumed to be one of the enzymes responsible for the degradation of the polymer carrier in vivo.	Diamines	34-41	cathepsin B	Homo sapiens	122-133
11671050-2	1999	Retro-model adducts containing the specially designed chiral diamine ligand, Bip = 2,2"-bipiperidine, are dramatically less fluxional.	Diamines	61-68	heat shock protein family A (Hsp70) member 5	Homo sapiens	77-80
10379569-3	1999	The rate of each decarboxylase catalyzed reaction was measured by monitoring the production of the respective diamine by a plant tissue diamino oxidase (DAO) based bioelectrode.	Diamines	110-117	D-amino acid oxidase	Bos taurus	136-151
10379569-3	1999	The rate of each decarboxylase catalyzed reaction was measured by monitoring the production of the respective diamine by a plant tissue diamino oxidase (DAO) based bioelectrode.	Diamines	110-117	D-amino acid oxidase	Bos taurus	153-156
10999248-2	2000	The incorporation of a N-Boc protected monoamine or diamine side arm into the backbone of the 2",3"-dideoxy-3"-thiacytidine 1 (BCH-189) provided an increase in antiviral potency, which could be several orders magnitude greater than the parent drug (1) depending on the cell culture systems used (MT-4 or MDMs).	Diamines	52-59	metallothionein 4	Homo sapiens	296-300
10201843-2	1999	A novel series of benzo[b]thiophene diamine thrombin inhibitors with a conformationally restricted C3-side chain 3 was investigated.	Diamines	36-43	coagulation factor II, thrombin	Homo sapiens	44-52
9725894-2	1998	Both monoamines and diamines block Kir2.1 channels, with potency increasing as the alkyl chain length increases (from 2 to 12 methylene groups), indicating a strong hydrophobic interaction with the blocking site.	Diamines	20-28	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	35-41
9950185-9	1999	In this case, particular nanoparticles functionalized with aliphatic diamines bound significantly higher amounts of fibrinogen than all other ligands.	Diamines	69-77	fibrinogen beta chain	Homo sapiens	116-126
9681017-5	1998	Enzyme activity assays show that ATAO1 preferentially oxidizes the aliphatic diamine putrescine with production of the corresponding aldehyde, ammonia and hydrogen peroxide, a recognized plant signal molecule and substrate for peroxidases.	Diamines	77-84	amine oxidase 1	Arabidopsis thaliana	33-38
9489756-1	1998	The enzyme diamine oxidase (DAO) catalyzes the oxidative deamination of histamine, diamines, and polyamines.	Diamines	83-91	D-amino-acid oxidase	Gallus gallus	11-26
9489756-1	1998	The enzyme diamine oxidase (DAO) catalyzes the oxidative deamination of histamine, diamines, and polyamines.	Diamines	83-91	D-amino-acid oxidase	Gallus gallus	28-31
7517727-3	1994	With this method and diamine substrates cadaverine or putrescine, or polyamine substrates spermidine or spermine as substrates, DAOX was localized species-independently but substrate-dependently in the basolateral cytoplasm and/or plasma membrane of small intestinal enterocytes of rats, mice and gerbils.	Diamines	21-28	amine oxidase, copper containing 1	Rattus norvegicus	128-132
9517003-1	1998	Four cDNAs for spermidine synthase (SPDS), which converts the diamine putrescine to the higher polyamine spermidine using decarboxylated S-adenosylmethionine as the co-factor, were isolated from Nicotiana sylvestris, Hyoscyamus niger, and Arabidopsis thaliana.	Diamines	62-69	spermidine synthase	Nicotiana sylvestris	15-34
9517003-1	1998	Four cDNAs for spermidine synthase (SPDS), which converts the diamine putrescine to the higher polyamine spermidine using decarboxylated S-adenosylmethionine as the co-factor, were isolated from Nicotiana sylvestris, Hyoscyamus niger, and Arabidopsis thaliana.	Diamines	62-69	spermidine synthase	Nicotiana sylvestris	36-40
9217025-1	1997	Diamine oxidase, the enzyme catalyzing the oxidative deamination of histamine and other diamines, was purified from porcine kidney and porcine intestine.	Diamines	88-96	amine oxidase copper containing 1	Homo sapiens	0-15
8912017-8	1996	Our results suggest that intestinal diamine oxidase clears the blood from diamines and prevents luminal uptake of putrescine.	Diamines	74-82	amine oxidase, copper containing 1	Rattus norvegicus	36-51
7636868-0	1995	Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.	Diamines	0-7	deoxyhypusine synthase	Cricetulus griseus	62-84
8941383-2	1996	The substitution of the piperazine ring in the GBR structure with other diamine moieties resulted in the retention of the high affinity of new ligands for the DAT.	Diamines	72-79	solute carrier family 6 member 3	Homo sapiens	159-162
7741045-0	1994	Diamine oxidase in relation to diamine and polyamine metabolism.	Diamines	31-38	amine oxidase copper containing 1	Homo sapiens	0-15
7741045-1	1994	Diamine oxidase catalyzes the oxidative deamination of short chain aliphatic diamines, like putrescine, and histamine.	Diamines	77-85	amine oxidase copper containing 1	Homo sapiens	0-15
8357843-2	1993	In the testosterone-induced hypertrophic and antifolate (N10-propargyl,5,6-dideazafolic acid, CB 3717)-induced hyperplastic mouse kidney models, a marked increase of two diamine levels--putrescine and cadaverine--occurred which paralleled induced ornithine decarboxylase (ODC) activity.	Diamines	170-177	ornithine decarboxylase, structural 1	Mus musculus	247-270
8357843-2	1993	In the testosterone-induced hypertrophic and antifolate (N10-propargyl,5,6-dideazafolic acid, CB 3717)-induced hyperplastic mouse kidney models, a marked increase of two diamine levels--putrescine and cadaverine--occurred which paralleled induced ornithine decarboxylase (ODC) activity.	Diamines	170-177	ornithine decarboxylase, structural 1	Mus musculus	272-275
8357303-3	1993	Surprisingly its diamine ligand meso-1 was only marginally active.	Diamines	17-24	transcription factor 15	Mus musculus	32-38
1533270-6	1992	The shortest diamines (DA2 and DA3) acted as weak partial agonists, enhancing the binding of [3H[MK-801.	Diamines	13-21	piezo type mechanosensitive ion channel component 2	Homo sapiens	31-34
1458548-0	1992	Isotopically sensitive regioselectivity in the oxidative deamination of a homologous series of diamines catalyzed by diamine oxidase.	Diamines	95-103	amine oxidase copper containing 1	Homo sapiens	117-132
1458548-1	1992	The equivalence of aminomethylene groups in selected diamine substrates of diamine oxidase was exploited for the determination of intramolecular isotope effects.	Diamines	53-60	amine oxidase copper containing 1	Homo sapiens	75-90
1606047-7	1992	In competitive radiometric receptor binding assays with rat uterine estrogen receptor, samples of the unlabeled diamine and Pt-diamine complex have apparent binding affinities of 53 +/- 3% and 32 +/- 11%, respectively, relative to estradiol (RBA = 100% as standard).	Diamines	112-119	estrogen receptor 1	Rattus norvegicus	68-85
1606047-8	1992	However, attempts to observe the binding of the 191Pt-diamine complex with the estrogen receptor were complicated by a very high level of non-receptor binding, an irreversible binding to proteins in the receptor preparation, and a degradation of the platinum complex that, in part, releases the diamine.	Diamines	54-61	estrogen receptor 1	Rattus norvegicus	79-96
1533270-8	1992	The longest diamines tested (DA8-DA12) acted as inverse agonists; they inhibited binding in the absence or presence of spermine, and this inhibition was blocked by the selective polyamine antagonist diethylenetriamine.	Diamines	12-20	myosin heavy chain 3	Homo sapiens	29-32
1533270-7	1992	Intermediate-length diamines (DA4-DA7) were selective polyamine antagonists, having little or no effect on binding of [3H]MK-801 measured in the absence of spermine but inhibiting binding measured in the presence of spermine.	Diamines	20-28	DA4	Homo sapiens	30-33
1533270-7	1992	Intermediate-length diamines (DA4-DA7) were selective polyamine antagonists, having little or no effect on binding of [3H]MK-801 measured in the absence of spermine but inhibiting binding measured in the presence of spermine.	Diamines	20-28	myosin heavy chain 8	Homo sapiens	34-37
34871830-2	2022	It is catalysed by GCN5-related N-acetyltransferases, which transfer acetyl groups from acetyl-coenzyme A to the primary amino groups of spermidine, spermine (Spm), or other polyamines and diamines, as was shown for the human Spermidine/Spermine N1-acetyltransferase 1 (HsSSAT1).	Diamines	189-197	lysine acetyltransferase 2A	Homo sapiens	19-23
1627273-1	1992	The protein-bound polysaccharide of Coriolus versicolor QUEL (PS-K) has been found to express antioxidant activity as an "ion-radical scavenger" in diamine oxidation reactions.	Diamines	148-155	TAO kinase 2	Homo sapiens	62-66
1325589-13	1992	More specifically, the ability of these diamines to block depolarization-induced influxes of Ca++ may protect the CA3 cells from the cytotoxic effects of persistent depolarization.	Diamines	40-48	carbonic anhydrase 3	Mus musculus	114-117
1805240-4	1991	In vivo experiments using monoamine oxidase or diamine oxidase inhibitors suggested the participation of both enzymes in the formation of the amino acid from the diamine in rat organs other than the brain, where diamine oxidase appeared to play the major role.	Diamines	47-54	amine oxidase, copper containing 1	Rattus norvegicus	212-227
1983156-4	1990	Diamines are poor substrates for SSAO or are not acted upon by the enzyme.	Diamines	0-8	amine oxidase, copper containing 3	Rattus norvegicus	33-37
2115243-1	1990	The key-enzyme for the metabolism of diamines in man is diamine oxidase (DAO).	Diamines	37-45	amine oxidase copper containing 1	Homo sapiens	56-71
2115243-1	1990	The key-enzyme for the metabolism of diamines in man is diamine oxidase (DAO).	Diamines	37-45	amine oxidase copper containing 1	Homo sapiens	73-76
34871830-2	2022	It is catalysed by GCN5-related N-acetyltransferases, which transfer acetyl groups from acetyl-coenzyme A to the primary amino groups of spermidine, spermine (Spm), or other polyamines and diamines, as was shown for the human Spermidine/Spermine N1-acetyltransferase 1 (HsSSAT1).	Diamines	189-197	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	226-268
34696588-6	2021	It is found that the process of transimination involving serine and PLP at the active site of the SHMT enzyme takes place through different elementary steps such as the formation of the first geminal diamine intermediate (GDI1), transfer of a proton from the substrate serine to the phenolic oxygen of PLP, followed by another proton transfer from PLP to the amine nitrogen of lysine with the formation of the second geminal diamine intermediate (GDI2), and finally, detachment of the active site lysine residue from PLP to produce the external aldimine.	Diamines	200-207	serine hydroxymethyltransferase 1	Homo sapiens	98-102
34696588-6	2021	It is found that the process of transimination involving serine and PLP at the active site of the SHMT enzyme takes place through different elementary steps such as the formation of the first geminal diamine intermediate (GDI1), transfer of a proton from the substrate serine to the phenolic oxygen of PLP, followed by another proton transfer from PLP to the amine nitrogen of lysine with the formation of the second geminal diamine intermediate (GDI2), and finally, detachment of the active site lysine residue from PLP to produce the external aldimine.	Diamines	200-207	GDP dissociation inhibitor 1	Homo sapiens	222-226
34696588-6	2021	It is found that the process of transimination involving serine and PLP at the active site of the SHMT enzyme takes place through different elementary steps such as the formation of the first geminal diamine intermediate (GDI1), transfer of a proton from the substrate serine to the phenolic oxygen of PLP, followed by another proton transfer from PLP to the amine nitrogen of lysine with the formation of the second geminal diamine intermediate (GDI2), and finally, detachment of the active site lysine residue from PLP to produce the external aldimine.	Diamines	425-432	serine hydroxymethyltransferase 1	Homo sapiens	98-102
34464454-6	2021	Patients with AOX1 rs6729738 CC (aldehyde oxidase; OR 6.69, 95%CI 2.19-20.41; p=0.001) or ABP1 rs12539 (diamine oxidase; OR 3.96, 95%CI 1.62-9.73; p=0.002) were more likely to respond.	Diamines	104-111	amine oxidase copper containing 1	Homo sapiens	90-94
34771902-3	2021	PAI terpolymers were prepared by compounding two diamine monomers, and the effects of trifluoromethyl on heat resistance, friction and wear properties, hydrophobic properties and mechanical properties of PAI materials were studied.	Diamines	49-56	serpin family E member 1	Homo sapiens	0-3
34202624-0	2021	Antibacterial Activity of Co(III) Complexes with Diamine Chelate Ligands against a Broad Spectrum of Bacteria with a DNA Interaction Mechanism.	Diamines	49-56	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	26-33
34202624-2	2021	Two Co(III) complexes with diamine chelate ligands ((CoCl2(dap)2)Cl (1) and (CoCl2(en)2)Cl (2)) (where dap = 1,3-diaminopropane, en = ethylenediamine) were synthesized and characterized by elemental analysis, an ATR technique, and a scan method and sequentially tested against Gram-positive and Gram-negative bacteria.	Diamines	27-34	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	4-11
2608471-1	1989	Adenosine, inosine and guanosine derivatives were prepared, modified at the C-8 atom with the aid of diamines (1,3-diaminopropane, 1,4-diaminobutane and 1,5-diaminopentane).	Diamines	101-109	homeobox C8	Homo sapiens	76-79
35631907-3	2022	Herein, a series of polymers with BNB-doped pi-system as a pendant group were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization from NBN-containing vinyl monomers, which was prepared via intermolecular dehydration reaction between boronic acid and diamine moieties in one pot.	Diamines	284-291	nibrin	Homo sapiens	169-172
35229256-6	2022	Additionally, piglets in the L-OTM and M-OTM groups had significantly higher villus height than those in the ITM group, and the M-OTM group piglets had lower serum diamine oxidase content and higher ileal ZO-1 and occludin protein expression levels than those in the ITM group.	Diamines	164-171	claudin 11	Homo sapiens	130-133
2499956-6	1989	ODC activity, which was much greater in cultures stimulated with Con A than LPS, was markedly decreased by inclusion of diamine or DFMO in the culture medium.	Diamines	120-127	ornithine decarboxylase 1	Homo sapiens	0-3
34071853-3	2021	The two diamines were polymerized with pyromellitic dianhydride (PMDA) to prepare two isomeric polyimides (M-2,7-CPPI and 2,7-CPPI), respectively.	Diamines	8-16	cathepsin C	Homo sapiens	113-117
34071853-3	2021	The two diamines were polymerized with pyromellitic dianhydride (PMDA) to prepare two isomeric polyimides (M-2,7-CPPI and 2,7-CPPI), respectively.	Diamines	8-16	cathepsin C	Homo sapiens	126-130
35421578-4	2022	Addressing resistance, here we describe discovery and development of a novel, proprietary spirocyclic diamine-substituted aryl phosphine oxide series of inhibitors, which led to the identification of WX-0593 (16a) as a potent ALK inhibitor.	Diamines	102-109	anaplastic lymphoma kinase	Mus musculus	226-229
35533679-1	2022	Spontaneously sp2-carbonized polyamides (PA1, PA2) were prepared via Knoevenagel-type side reactions of malonyl moieties under mild conditions in the polycondensation of dicarbonyl chloride and diamine.	Diamines	194-201	Sp2 transcription factor	Homo sapiens	14-17
35533679-1	2022	Spontaneously sp2-carbonized polyamides (PA1, PA2) were prepared via Knoevenagel-type side reactions of malonyl moieties under mild conditions in the polycondensation of dicarbonyl chloride and diamine.	Diamines	194-201	PAXIP1 associated glutamate rich protein 1	Homo sapiens	41-44
35323809-4	2022	In this work, three diamines, 1,4-cyclohexanediamine (CHD), ethylenediamine (EDA), and p-phenylenediamine (PPD), are reacted with TMC separately to fabricate a thin film composite polyamide membrane for dye desalination.	Diamines	20-28	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	130-133
35323809-6	2022	The surface morphology, roughness, and thickness of the polyamide layer are dependent on the reactivity of the diamines with TMC.	Diamines	111-119	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	125-128
35119858-5	2022	The conformational stability of the diamine side chain and the CFA motif of 18 in the orthosteric site of EGFRDM is identified as key for the disparate binding mechanism and inhibitory prowess of 18 with respect to EGFRWT and EGFRDM and 18"s higher selectivity than 7.	Diamines	36-43	epidermal growth factor receptor	Homo sapiens	106-112
35119858-5	2022	The conformational stability of the diamine side chain and the CFA motif of 18 in the orthosteric site of EGFRDM is identified as key for the disparate binding mechanism and inhibitory prowess of 18 with respect to EGFRWT and EGFRDM and 18"s higher selectivity than 7.	Diamines	36-43	epidermal growth factor receptor	Homo sapiens	215-221
35119858-5	2022	The conformational stability of the diamine side chain and the CFA motif of 18 in the orthosteric site of EGFRDM is identified as key for the disparate binding mechanism and inhibitory prowess of 18 with respect to EGFRWT and EGFRDM and 18"s higher selectivity than 7.	Diamines	36-43	epidermal growth factor receptor	Homo sapiens	226-232
2775479-5	1989	4) Dealkylation of N-alkyl derivatives by polyamine oxidase in vivo is a method to accumulate diamines in brain, and to release intracellularly an aldehyde from a stable prodrug.	Diamines	94-102	polyamine oxidase	Homo sapiens	42-59
3366303-0	1988	Kinetic study of the inhibition of rat liver ornithine decarboxylase by diamines; considerations on the mechanism of interaction between enzyme and inhibitor.	Diamines	72-80	ornithine decarboxylase 1	Rattus norvegicus	45-68
3366303-2	1988	Partially purified rat liver ornithine decarboxylase is inhibited by several diamines including putrescine, 1,3-diaminopropane, cadaverine and p-phenylenediamine.	Diamines	77-85	ornithine decarboxylase 1	Rattus norvegicus	29-52
3801648-1	1987	Successive thrombin modification by carbodiimide and aliphatic diamines decreases esterase and fibrin-coagulating activity of the enzyme.	Diamines	63-71	coagulation factor II, thrombin	Homo sapiens	11-19
3627986-2	1987	When the diamine derivatives (X = NH2) were used, the time course of the stability of mTr groups on the amino group and the phosphoramidate linkage with 80% aq.	Diamines	9-16	telomerase RNA component	Mus musculus	86-89
3114026-3	1987	The efficacy of the dose of inhibitor used was monitored by analysis of the diamine product of ODC, putrescine.	Diamines	76-83	ornithine decarboxylase 1	Rattus norvegicus	95-98
4024044-5	1985	Fibrinogen modified with diamines does not lose the ability to be co-polymerized in the three-dimensional fibrin clot under the action of thrombin and acquires increased stability towards proteolytic degradation.	Diamines	25-33	fibrinogen beta chain	Homo sapiens	0-10
4029399-2	1985	Upon binding the steroidal diamine dipyrandenium to poly d(AsT) and poly d(TsA), 31P NMR shows that it is the d(ApT) phosphodiester bond which is most perturbed.	Diamines	27-34	solute carrier family 17 member 5	Homo sapiens	59-62
4049780-6	1985	Urokinase coupling to fibrinogen via aliphatic diamine "spacer group" increases the affinity of the modified enzyme derivative to thrombus material.	Diamines	47-54	fibrinogen beta chain	Homo sapiens	22-32
2872883-9	1986	The behaviour of DAO suggests that the enzyme plays an important role in the control of intracellular diamine concentration.	Diamines	102-109	amine oxidase, copper containing 1	Rattus norvegicus	17-20
3083714-4	1986	A plant diamine oxidase is used for the assay of diamines.	Diamines	49-57	amine oxidase copper containing 1	Homo sapiens	8-23
3990509-1	1985	Amines, diamines and polyamines inhibit the erythropoietin-stimulated incorporation of 59Fe into newly-synthesized heme by fetal mouse liver cells in short-term culture.	Diamines	8-16	erythropoietin	Mus musculus	44-58
4072800-6	1985	Exogenously administered diamines or polyamines cause rapid decay of ODC activity and induce antizyme that binds to ODC and inactivates it.	Diamines	25-33	ornithine decarboxylase 1	Rattus norvegicus	69-72
4072800-6	1985	Exogenously administered diamines or polyamines cause rapid decay of ODC activity and induce antizyme that binds to ODC and inactivates it.	Diamines	25-33	ornithine decarboxylase 1	Rattus norvegicus	116-119
4072800-10	1985	Only small amounts of ODC-antizyme complex were detected in rat liver and cultured hepatocytes, even during the period of rapid ODC decay caused by exogenously added diamines.	Diamines	166-174	ornithine decarboxylase 1	Rattus norvegicus	22-25
4072800-10	1985	Only small amounts of ODC-antizyme complex were detected in rat liver and cultured hepatocytes, even during the period of rapid ODC decay caused by exogenously added diamines.	Diamines	166-174	ornithine decarboxylase 1	Rattus norvegicus	128-131
6679729-0	1983	Stabilization of human prostatic acid phosphatase by cross-linking with diamines.	Diamines	72-80	acid phosphatase 3	Homo sapiens	23-49
6242540-0	1984	[Effects of diamines and their derivatives on ornithine decarboxylase activity in mouse sarcoma 180 in vivo].	Diamines	12-20	ornithine decarboxylase, structural 1	Mus musculus	46-69
6696980-3	1984	It is suggested that diamines affect the rhythm of protein synthesis by inhibiting the key enzyme of polyamines--ornithine decarboxylase.	Diamines	21-29	ornithine decarboxylase 1	Homo sapiens	113-136
3934184-0	1985	Inhibition of ornithine decarboxylase activity and cell growth by diamines: a comparison between the effects of two homologs, 1,3-diaminopropane and 1,4-diaminobutane (putrescine).	Diamines	66-74	ornithine decarboxylase, structural 1	Mus musculus	14-37
6425061-4	1984	Ig-ovalbumin insoluble complexes bearing C1 are also dissociated by lysine and the above-mentioned diamines used at the same concentration: C1q remains bound to the complexes whereas the C1r2-C1s2 complex is partially solubilized.	Diamines	99-107	complement C1q A chain	Homo sapiens	140-143
6428252-9	1984	These results indicate that ethanol modifies in the gastroduodenal tract the activity of diamine oxidase the enzyme which regulates the physiologic activity of histamine in gastric secretion and oxidizes the toxic diamines of dietary and bacterial origin.	Diamines	214-222	amine oxidase, copper containing 1	Rattus norvegicus	89-104
6786807-0	1981	A fluorometric assay for total diamines in human urine using human placental diamine oxidase.	Diamines	31-39	amine oxidase copper containing 1	Homo sapiens	77-92
6980883-6	1982	However, C4b exhibits a distinct preference for diamines, putrescine and 1,3-diaminopropane, over monoamines of the same alkyl chain length, s-butylamine and n-propylamine.	Diamines	48-56	complement C4B (Chido blood group)	Homo sapiens	9-12
6805264-6	1982	In conclusion, we present some evidence to suggest that mammalian diamine oxidase, despite a high reaction rate with putrescine, is better adapted to histamine oxidation, whereas for plant enzymes the diamines are preferred substrates.	Diamines	201-209	amine oxidase copper containing 1	Homo sapiens	66-81
6790686-0	1981	Hog kidney diamine oxidase conversion of biogenic diamines to inhibitors of cell proliferation.	Diamines	50-58	amine oxidase copper containing 1	Homo sapiens	11-26
6786807-2	1981	The diamines were purified from the urine by cation-exchange chromatography and incubated with human placental diamine oxidase.	Diamines	4-12	amine oxidase copper containing 1	Homo sapiens	111-126
7435118-2	1980	In addition, the dose-response relationship of hCG and its effect on the diamine formation and the effect of hCG on the content of diamines and polyamines in the ovaries and the urine were studied.	Diamines	73-80	chorionic gonadotropin subunit beta 5	Homo sapiens	47-50
7195403-1	1981	A detailed procedure of a new photometric assay for total diamines and polyamines in human urine using soybean seedling amine oxidase (SSAO) as an enzyme reagent is described.	Diamines	58-66	amine oxidase copper containing 2	Homo sapiens	135-139
7195403-2	1981	It is based on the unique substrate specificity of SSAO that the enzyme is active toward all diamines and polyamines.	Diamines	93-101	amine oxidase copper containing 2	Homo sapiens	51-55
6787849-5	1981	Adrenalectomized rats metabolize the diamine at a reduced rate, a result consistent with the previously demonstrated decrease of DAO in the tissues of several species of animal.	Diamines	37-44	amine oxidase, copper containing 1	Rattus norvegicus	129-132
7435118-2	1980	In addition, the dose-response relationship of hCG and its effect on the diamine formation and the effect of hCG on the content of diamines and polyamines in the ovaries and the urine were studied.	Diamines	131-139	chorionic gonadotropin subunit beta 5	Homo sapiens	109-112
7396844-0	1980	Inhibition of ornithine decarboxylase of HeLa cells by diamines and polyamines.	Diamines	55-63	ornithine decarboxylase 1	Homo sapiens	14-37
7190634-0	1980	The dual action of the non-physiological diamines 1,3 diaminopropane and cadaverine on ornithine decarboxylase of HTC cells.	Diamines	41-49	ornithine decarboxylase 1	Rattus norvegicus	87-110
7205597-2	1980	The diamines (1,3-propanediamine, 1,5-pentanediamine, and 1,6-hexanediamine) dramatically decreased neuroblastoma replication and inhibited the rate-limiting enzyme, ornithine decarboxylase.	Diamines	4-12	ornithine decarboxylase 1	Homo sapiens	166-189
7396844-8	1980	Much higher concentrations (1mm) of the non-physiological diamines, 1,3-diamino-propane or 1,3-diamino-2-hydroxypropane, are required to eliminate the stimulation of ornithine decarboxylase in re-fed HeLa-cell cultures.	Diamines	58-66	ornithine decarboxylase 1	Homo sapiens	166-189
7396844-10	1980	A heat-labile, non-diffusible inhibitor, comparable with the inhibitory protein ornithine decarboxylase antizyme, is induced in HeLa cells by the addition of exogenous diamines or polyamines.	Diamines	168-176	ornithine decarboxylase 1	Homo sapiens	80-103
486108-0	1979	Effects of diamines on ornithine decarboxylase activity in control and virally transformed mouse fibroblasts.	Diamines	11-19	ornithine decarboxylase, structural 1	Mus musculus	23-46
457786-1	1979	Exogenous diamines and polyamines added to rat hepatoma (HTC) cells in culture rapidly decrease ornithine decarboxylase (ODC) activity.	Diamines	10-18	ornithine decarboxylase 1	Rattus norvegicus	96-119
457786-1	1979	Exogenous diamines and polyamines added to rat hepatoma (HTC) cells in culture rapidly decrease ornithine decarboxylase (ODC) activity.	Diamines	10-18	ornithine decarboxylase 1	Rattus norvegicus	121-124
426782-0	1979	Diamine-induced inhibition of liver ornithine decarboxylase.	Diamines	0-7	ornithine decarboxylase 1	Rattus norvegicus	36-59
426782-9	1979	However, the idea that injection of various diamines, also in vivo, induces acute formation of macromolecular inhibitors, which reversibly combine with the enzyme, was supported by the finding that the ornithine decarboxylase activity remaining after diaminopropane injection appeared to be more stable to increased ionic strength than the enzyme activity obtained from somatotropin-treated rats.	Diamines	44-52	ornithine decarboxylase 1	Rattus norvegicus	202-225
426782-14	1979	These results are in accord with the hypothesis that various diamines may result in rapid formation of macromolecular inhibitors to ornithine decarboxylase in vivo, which, after combination with the enzyme, abolish the catalytic activity but at the same time prevent the intracellular degradation of the enzyme protein.	Diamines	61-69	ornithine decarboxylase 1	Rattus norvegicus	132-155
745086-11	1978	Under the influence of the diamine oxidase inhibitor aminoguanidine the general pattern of excretion of diamines and polyamines in pregnant rats remained essentially unchanged but the total amount excreted increased.	Diamines	104-112	amine oxidase, copper containing 1	Rattus norvegicus	27-42
646807-1	1978	Rat liver ornithine decarboxylase activity was decreased by administration of putrescine (1,4-diaminobutane) or other diamines, including 1,3-diaminopropane, 1,5-diaminopentane and 1,6-diaminohexane.	Diamines	118-126	ornithine decarboxylase 1	Rattus norvegicus	10-33
27507-0	1978	Transglutaminase-catalyzed cross-linking through diamines and polyamines.	Diamines	49-57	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	0-16
27507-2	1978	Production of this heretofore undescribed linkage by guinea pig liver transglutaminase was demonstrated by the use of high performance liquid chromatography in a model system using glutamine peptide derivatives and a variety of diamines and polyamines.	Diamines	228-236	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	70-86
670306-0	1978	The modulation of the induction of ornithine decarboxylase by spermine, spermidine and diamines.	Diamines	87-95	ornithine decarboxylase 1	Homo sapiens	35-58
96921-8	1978	These results favour the concept of a role of pyridoxal cofactor in the metabolism of diamines, presumably at the diamine oxidase stage.	Diamines	86-94	amine oxidase, copper containing 1	Rattus norvegicus	114-129
646807-5	1978	This return correlated with the rapid loss of the diamines from the liver, and the decrease in activity could be slightly prolonged by treatment with aminoguanidine, a diamine oxidase inhibitor.	Diamines	50-58	amine oxidase, copper containing 1	Rattus norvegicus	168-183
646807-6	1978	A decrease in ornithine decarboxylase activity by these diamines was accompanied by the accumulation in the liver of a nondiffusible inhibitor that decreased the activity of a purified ornithine decarboxylase preparation.	Diamines	56-64	ornithine decarboxylase 1	Rattus norvegicus	14-37
646807-6	1978	A decrease in ornithine decarboxylase activity by these diamines was accompanied by the accumulation in the liver of a nondiffusible inhibitor that decreased the activity of a purified ornithine decarboxylase preparation.	Diamines	56-64	ornithine decarboxylase 1	Rattus norvegicus	185-208
891927-0	1977	Inhibition of ornithine decarboxylase by diamines in regenerating rat liver.	Diamines	41-49	ornithine decarboxylase 1	Rattus norvegicus	14-37
735640-0	1978	Evidence for several mechanisms involved in the regulation of ornithine decarboxylase by diamines during rat liver regeneration.	Diamines	89-97	ornithine decarboxylase 1	Rattus norvegicus	62-85
606241-11	1977	The decrease in ornithine decarboxylase activity observed after injections of diamines (putrescine) in the ventral prostate was apparently associated with a similar decrease in the amount of immunoreactive protein as revealed by immunotitration of the enzyme with antiserum to rat ornithine decarboxylase.	Diamines	78-86	ornithine decarboxylase 1	Rattus norvegicus	16-39
606241-11	1977	The decrease in ornithine decarboxylase activity observed after injections of diamines (putrescine) in the ventral prostate was apparently associated with a similar decrease in the amount of immunoreactive protein as revealed by immunotitration of the enzyme with antiserum to rat ornithine decarboxylase.	Diamines	78-86	ornithine decarboxylase 1	Rattus norvegicus	281-304
901422-12	1977	Chronic treatment of the mice with diamines resulted in a virtually complete disappearance of ornithine decarboxylase activity, and after 24h a significant decline in spermidine accumulation.	Diamines	35-43	ornithine decarboxylase, structural 1	Mus musculus	94-117
901422-9	1977	Various diamines injected into mice bearing ascites cells rapidly and powerfully decreased ornithine decarboxylase activity in the carcinoma cells, apparently through a mechanism that was not a direct inhibition of the enzyme in vitro.	Diamines	8-16	ornithine decarboxylase, structural 1	Mus musculus	91-114
402498-2	1977	It metabolises also a variety of diamines such as putrescine and cadaverine and is generally accepted to be identical with histaminase.	Diamines	33-41	amine oxidase copper containing 1	Homo sapiens	123-134
14027-0	1977	Regulation of ornithine decarboxylase by diamines in regenerating rat liver.	Diamines	41-49	ornithine decarboxylase 1	Rattus norvegicus	14-37
33200483-2	2021	Five chiral binuclear aluminum methyl complexes (rac1 to rac5) are synthesized by using chiral binaphthalene diamine ligand and characterized by both 1 H and 13 C NMR spectroscopy.	Diamines	109-116	Rac family small GTPase 1	Homo sapiens	49-53
842265-8	1977	These experiments are consistent with the view that diamines and spermidine might conceivably control the activity of ornithine decarboxylase in regenerating rat liver in vivo at steps beyond transcription.	Diamines	52-60	ornithine decarboxylase 1	Rattus norvegicus	118-141
808238-2	1975	The procedure is based upon the binding of histaminase to cadaverine, a diamine substrate for the enzyme, which is coupled to Sepharose.	Diamines	72-79	amine oxidase copper containing 1	Homo sapiens	43-54
178010-0	1975	Hydroxyamino compounds produced by the oxidation of diamines with diamine oxidase in the presence of alcohol dehydrogenase.	Diamines	52-60	amine oxidase copper containing 1	Sus scrofa	66-81
178010-1	1975	When the diamines putrescine, cadaverine, cystamine and lanthionamine are oxidized by purified pig kidney diamine oxidase in the presence of NADH and either liver or yeast crystalline alcohol dehydrogenase, NADH is oxidized.	Diamines	9-17	amine oxidase copper containing 1	Sus scrofa	106-121
5001329-0	1971	[Improvement of the indigo disulfonate method of determination of the diamine: oxygen oxidoreductase (E.C.1.4.3.6.)	Diamines	70-77	thioredoxin reductase 1	Homo sapiens	86-100
32519549-8	2020	The best Co-PA TFC membranes, which were synthesized using diamines containing four carbon atoms, achieved a significant improvement in NF membrane performance and selectivity (pure water flux = 56.9 L m-2 h-1 and salt and dye rejection in the range of 46.2-99.2%).	Diamines	59-67	H1.5 linker histone, cluster member	Homo sapiens	206-209
32877741-1	2020	Hybridisation of amino-pyrimidine based SYK inhibitors (e.g. 1a) with previously reported diamine-based SYK inhibitors (e.g. TAK-659) led to the identification and optimisation of a novel pyrimidine-based series of potent and selective SYK inhibitors, where the original aminomethylene group was replaced by a 3,4-diaminotetrahydropyran group.	Diamines	90-97	spleen associated tyrosine kinase	Homo sapiens	104-107
32877741-1	2020	Hybridisation of amino-pyrimidine based SYK inhibitors (e.g. 1a) with previously reported diamine-based SYK inhibitors (e.g. TAK-659) led to the identification and optimisation of a novel pyrimidine-based series of potent and selective SYK inhibitors, where the original aminomethylene group was replaced by a 3,4-diaminotetrahydropyran group.	Diamines	90-97	spleen associated tyrosine kinase	Homo sapiens	104-107
32845614-3	2020	Herein, we report a novel series of [Ag(N^N)(P^P)]PF6 complexes exhibiting highly efficient thermally activated delayed fluorescence by using easily accessible neutral diamine ligands and commercially available ancillary diphosphine chelates.	Diamines	168-175	sperm associated antigen 17	Homo sapiens	50-53
32609140-3	2020	The bridged skeleton of PrL was changed to diamines 1-methyl-ethylenediamine, trimethylenediamine and 2,2"-dimethyl-trimethylenediamine, and the corresponding ligands were designated as Lme, Lpr and Ldmpr, for each Pr in these complexes upon UV-excitation.	Diamines	43-51	prolactin	Homo sapiens	24-27
32784090-1	2020	A series of mechanism-based heteroaryl urea fatty acid amide hydrolase (FAAH) inhibitors with fused bicyclic diamine cores is described.	Diamines	109-116	fatty-acid amide hydrolase-like	Rattus norvegicus	72-76
32784090-2	2020	In contrast to compounds built around a piperazine core, most of the fused bicyclic diamine bearing analogs prepared exhibited greater potency against rFAAH than the human enzyme.	Diamines	84-91	fatty-acid amide hydrolase-like	Rattus norvegicus	151-156
32911839-1	2020	A high-barrier polyimide (2,7-CPI) was synthesized through the polymerization of pyromellitic dianhydride (PMDA) and a novel diamine (2,7-CDA) containing carbazole moiety.	Diamines	125-132	cytidine deaminase	Homo sapiens	138-141
32178384-1	2020	Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme.	Diamines	153-161	amine oxidase copper containing 1	Homo sapiens	102-117
32278205-1	2020	A series of mono and bimetallic ruthenium(II) arene complexes bearing diamine (Ru1-6) were prepared and fully characterized by 1H, 13C, 19F, and 31P NMR spectroscopy and elemental analysis.	Diamines	70-77	Scm like with four mbt domains 1	Homo sapiens	79-82
32178384-1	2020	Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme.	Diamines	153-161	D-amino acid oxidase	Homo sapiens	119-123
32178384-1	2020	Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme.	Diamines	153-161	amine oxidase copper containing 1	Homo sapiens	125-129
32178384-1	2020	Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme.	Diamines	153-161	amine oxidase copper containing 3	Homo sapiens	239-245
32178384-1	2020	Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme.	Diamines	153-161	amine oxidase copper containing 3	Homo sapiens	247-251
31234018-1	2019	In this work, we designed a series of [Cu(NN)(PPh3)2]BF4 complexes with different optical edge values and emission colors from blue to red, where NN and PPh3 denoted a diamine ligand and triphenylphosphine, respectively.	Diamines	168-175	protein phosphatase 4 catalytic subunit	Homo sapiens	46-50
31234018-1	2019	In this work, we designed a series of [Cu(NN)(PPh3)2]BF4 complexes with different optical edge values and emission colors from blue to red, where NN and PPh3 denoted a diamine ligand and triphenylphosphine, respectively.	Diamines	168-175	protein phosphatase 4 catalytic subunit	Homo sapiens	153-157
31234018-6	2019	Detailed analysis on photophysical parameters suggested that the absorption edge of [Cu(NN)(PPh3)2]BF4 complex was controlled by conjugation length in diamine ligand.	Diamines	151-158	protein phosphatase 4 catalytic subunit	Homo sapiens	92-96
31194896-0	2019	Aminomethyl Transfer (Mannich) Reactions Between an O-Triethylsilylated Hemiaminal and Anilines, Rn C6 H5-n NH2 Leading to New Diamines, Triamines, Imines, or 1,3,5-Triazines Dependent upon Substituent R. The reactions of the Mannich reagent Et3 SiOCH2 NMe2 (1) with a variety of anilines (mono-substituted RC6 H4 NH2 , R=H, 4-CN, 4-NO2 , 4-Ph, 4-Me, 4-MeO, 4-Me2 N; di-substituted R2 C6 H3 NH2 , R2 =3,5-(CH3 )2 , 3,5-(CF3 )2 ; tri-substituted R3 C6 H2 NH2 , R3 =3,5-Me2 -4-Br and a "super bulky" aniline (Ar*NH2 ) [Ar*=2,6-bis(diphenylmethyl)-4-tert-butylphenyl]) led to the formation of a range of products dependent upon the substituent.	Diamines	127-135	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	253-257
31515915-3	2019	Interestingly, bioconjugation of native alpha-synuclein with a diamine molecule to increase the positive charge on the protein chain, and subsequently electrostatic coupling with PS forms a conjugate with a retained unordered structure, from which removal of water provides a highly stable alpha-helical (  74%) water-less liquid system.	Diamines	63-70	synuclein alpha	Homo sapiens	40-55
31016974-5	2019	Compared to the NCA polymerization initiated by the hexylamine (CH3(CH2)5NH2), the chain propagation rate of the NCA polymerization is increased by more than 600 times when initiated by its diamine analogue (1,6-diaminohexane, NH2(CH2)6NH2).	Diamines	190-197	CEA cell adhesion molecule 6	Homo sapiens	16-19
31016974-5	2019	Compared to the NCA polymerization initiated by the hexylamine (CH3(CH2)5NH2), the chain propagation rate of the NCA polymerization is increased by more than 600 times when initiated by its diamine analogue (1,6-diaminohexane, NH2(CH2)6NH2).	Diamines	190-197	CEA cell adhesion molecule 6	Homo sapiens	113-116
30255542-1	2018	A simple and efficient synthesis of NBN-doped conjugated polycyclic aromatic hydrocarbons (such as diazaborinines) has been accomplished by a catalyst-free intermolecular dehydration reaction at room temperature between boronic acid and diamine moieties with yields up to 99 %.	Diamines	237-244	nibrin	Homo sapiens	36-39
31028498-4	2019	By combining the Chit-PtNP, catechol, and TYRase interactions with the oxidation of TMB to form a yellow diamine (maximal absorbance at 450 nm), a colorimetric analytical method was developed for TYRase determination and inhibitor screening.	Diamines	105-112	tyrosinase	Homo sapiens	42-48
31028498-4	2019	By combining the Chit-PtNP, catechol, and TYRase interactions with the oxidation of TMB to form a yellow diamine (maximal absorbance at 450 nm), a colorimetric analytical method was developed for TYRase determination and inhibitor screening.	Diamines	105-112	tyrosinase	Homo sapiens	196-202
30684760-0	2019	Ru(II)/N-N/PPh3 complexes as potential anticancer agents against MDA-MB-231 cancer cells (N-N = diimine or diamine).	Diamines	107-114	caveolin 1	Homo sapiens	11-15
30661613-5	2019	The specific performance of DHAA molecular structure regulation, due to the condensation reaction between dicarbonyl group of DHAA and diamine group of OPD, that is confirmed by ESI-MS and 1H NMR spectra analysis, can remarkably enhance the selectivity of ALP detection, which is conceptually different from the previously reported ALP fluorescent assays.	Diamines	135-142	alkaline phosphatase, placental	Homo sapiens	256-259
30661613-5	2019	The specific performance of DHAA molecular structure regulation, due to the condensation reaction between dicarbonyl group of DHAA and diamine group of OPD, that is confirmed by ESI-MS and 1H NMR spectra analysis, can remarkably enhance the selectivity of ALP detection, which is conceptually different from the previously reported ALP fluorescent assays.	Diamines	135-142	alkaline phosphatase, placental	Homo sapiens	332-335
31131150-5	2018	Straightforward product manipulations to diamine and imidazolidinone derivatives are underscored by the synthesis of an NK1 antagonist.	Diamines	41-48	tachykinin receptor 1	Homo sapiens	120-123
29778798-1	2018	A series of inhibitors of NF-kappaB based on ursolic acid (UA) derivatives containing long-chain diamine moieties were designed and synthesized as well as evaluated the antitumor effects.	Diamines	97-104	nuclear factor kappa B subunit 1	Homo sapiens	26-35
30425424-4	2018	Down-regulatioin of SPDS gene resulted in decreased spermidine levels and a slight increase in the levels of its precursor, the diamine putrescine and the molecule downstream of Spd, the tetraamine spermine.	Diamines	128-135	spermidine synthase-like	Nicotiana tabacum	20-24
29778798-6	2018	Molecular docking study revealed that key interactions between 8c and the active site of NF-kappaB in which the bulky and strongly electrophilic group of long-chain diamine moieties were important for improving activity.	Diamines	165-172	nuclear factor kappa B subunit 1	Homo sapiens	89-98
29421697-0	2018	A new entry into the portfolio of alpha-glucosidase inhibitors as potent therapeutics for type 2 diabetes: Design, bioevaluation and one-pot multi-component synthesis of diamine-bridged coumarinyl oxadiazole conjugates.	Diamines	170-177	sucrase-isomaltase	Homo sapiens	34-51
29603670-2	2018	Herein, we prepared diamine-functionalized Mg2 (dobpdc) (H4 dobpdc=4,4"-dihydroxy-(1,1"-biphenyl)-3,3"-dicarboxylic acid).	Diamines	20-27	mucin 7, secreted	Homo sapiens	43-46
29874405-2	2018	The resulting fluidized MOF hybrid materials containing diamines coordinated at the open metal sites have been studied as CO2 solid sorbents from post-combustion flue gas showing similar performance than their bulk counterparts.	Diamines	56-64	lysine acetyltransferase 8	Homo sapiens	24-27
30072969-0	2018	Antifungal Activity and Mechanism of Action of the Co(III) Coordination Complexes With Diamine Chelate Ligands Against Reference and Clinical Strains of Candida spp.	Diamines	87-94	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	51-57
30072969-4	2018	In this study we examined the antifungal activity of Co(III) complexes with diamine chelate ligands against a broad spectrum of Candida species.	Diamines	76-83	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	53-60
30072969-12	2018	Our results suggest that both diamine complexes with Co(III) analogs caused damage to mitochondrial membrane or the membrane of the endoplasmic reticulum.	Diamines	30-37	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	53-60
30072969-14	2018	Co(III) complexes with diamine chelate ligands are non-toxic at concentrations active against Candida species.	Diamines	23-30	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	0-7
29221866-5	2018	A fast and reliable method based on a bare-silica capillary combining the effect of urea and diamine additives allowed to separate up to six different ApoC-III forms.	Diamines	93-100	apolipoprotein C3	Homo sapiens	151-159
29303497-3	2018	Three stereoisomers of the diamine cocrystallize in the centrosymmetric space group P21/c with Z" = 1.5.	Diamines	27-34	H3 histone pseudogene 16	Homo sapiens	84-87
29045155-0	2017	Diamine-Appended Mg2(dobpdc) Nanorods as Phase-Change Fillers in Mixed-Matrix Membranes for Efficient CO2/N2 Separations.	Diamines	0-7	mucin 7, secreted	Homo sapiens	17-20
29045055-1	2017	The lupin alkaloid sparteine is a well-known chiral diamine with a range of applications in asymmetric synthesis, as well as a blocker of voltage-gated sodium channels (VGSCs).	Diamines	52-59	5'-nucleotidase, cytosolic IIIA	Homo sapiens	4-9
28691317-2	2017	The 6FDA-DAT1-OH polyimide is thermally stable up to 440  C, shows excellent solubility in polar solvents, and has moderately high Brunauer-Teller-Emmett (BET) surface area of 160 m2 g-1 , as determined by nitrogen adsorption at -196  C. Hydroxyl functionalization applied to the rigid 3D triptycene-based diamine building block results in a polyimide that exhibits moderate pure-gas CO2 permeability of 70 Barrer combined with high CO2 /CH4 selectivity of 50.	Diamines	306-313	solute carrier family 6 member 3	Homo sapiens	9-13
28991466-3	2017	Here, we demonstrate that when appended with the chiral diamine trans-1,2-diaminocyclohexane (dach), Mg2(dobpdc) adsorbs carbon dioxide cooperatively to form ammonium carbamate chains, and the thermodynamics of CO2 capture are strongly influenced by enantioselective interactions within the chiral pores of the framework.	Diamines	56-63	mucin 7, secreted	Homo sapiens	101-112
29629084-0	2018	Overcoming double-step CO2 adsorption and minimizing water co-adsorption in bulky diamine-appended variants of Mg2(dobpdc).	Diamines	82-89	mucin 7, secreted	Homo sapiens	115-121
29629084-7	2018	Functionalization of Mg2(pc-dobpdc) with large diamines such as N-(n-heptyl)ethylenediamine results in optimal adsorption behavior, highlighting the advantage of tuning both the pore shape and the diamine size for the development of new adsorbents for carbon capture applications.	Diamines	47-55	mucin 7, secreted	Homo sapiens	28-34
29629084-7	2018	Functionalization of Mg2(pc-dobpdc) with large diamines such as N-(n-heptyl)ethylenediamine results in optimal adsorption behavior, highlighting the advantage of tuning both the pore shape and the diamine size for the development of new adsorbents for carbon capture applications.	Diamines	47-54	mucin 7, secreted	Homo sapiens	28-34
28004886-1	2017	A combined sonication and microwave irradiation procedure provides the most effective functionalization of ethylenediamine (en) and branched primary diamines of 1-methylethylenediamine (men) and 1,1-dimethylethylenediamine (den) onto the open metal sites of Mg2 (dobpdc) (1).	Diamines	149-157	mucin 7, secreted	Homo sapiens	258-261
28425525-6	2017	The DFT M06-2X/6-31G(d)//B3LYP/6-31+G(d) level of theory showed that the cyclic ee-1,2-CHDA (equatorial-equatorial form of 1,2-disubstituted cyclohexadiamine di-cation) binds to the G-tetrads very strongly (~70.0 kcal mol-1), with a much higher binding energy than the linear protonated diamines.	Diamines	287-295	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	27-30