PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32589370-5	2021	Meanwhile, anti-apoptotic activities of XAG against I/R-induced neuronal injury were evidenced and further illustrated that XAG elicits anti-apoptotic activities by suppressing excessive oxidative stress via nuclear factor erythroid-2-related factor 2 (Nrf2) activation.	xanthoangelol	124-127	NFE2 like bZIP transcription factor 2	Rattus norvegicus	208-251
33740160-10	2021	Moreover, we identified that xanthoangelol (XA) and 4-hydroxyderricin (4-HD) can directly bind to EPRS to block WNT/GSK-3beta/beta-catenin signaling pathway.	xanthoangelol	29-42	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	98-102
33740160-10	2021	Moreover, we identified that xanthoangelol (XA) and 4-hydroxyderricin (4-HD) can directly bind to EPRS to block WNT/GSK-3beta/beta-catenin signaling pathway.	xanthoangelol	29-42	glycogen synthase kinase 3 alpha	Homo sapiens	116-125
33740160-10	2021	Moreover, we identified that xanthoangelol (XA) and 4-hydroxyderricin (4-HD) can directly bind to EPRS to block WNT/GSK-3beta/beta-catenin signaling pathway.	xanthoangelol	29-42	catenin beta 1	Homo sapiens	126-138
32589370-5	2021	Meanwhile, anti-apoptotic activities of XAG against I/R-induced neuronal injury were evidenced and further illustrated that XAG elicits anti-apoptotic activities by suppressing excessive oxidative stress via nuclear factor erythroid-2-related factor 2 (Nrf2) activation.	xanthoangelol	124-127	NFE2 like bZIP transcription factor 2	Rattus norvegicus	253-257
32814570-0	2020	Retraction Note: Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma.	xanthoangelol	55-68	mitogen-activated protein kinase 8	Homo sapiens	116-119
32814570-0	2020	Retraction Note: Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma.	xanthoangelol	55-68	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-125
30621754-0	2019	Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma.	xanthoangelol	38-51	mitogen-activated protein kinase 8	Homo sapiens	99-102
30883849-4	2019	Although XAG treatment did not significantly reduce the viability of the Hep3B and Huh7 cell lines, it suppressed cell migration, invasion, and EMT.	xanthoangelol	9-12	IL2 inducible T cell kinase	Homo sapiens	144-147
30883849-5	2019	This anti-metastatic effect of XAG was due to induction of autophagy, because treatment with the autophagy inhibitor 3-methyadenine (3-MA) or knockdown of the pro-autophagy Beclin-1 effectively abrogated the XAG-induced suppression of metastasis.	xanthoangelol	31-34	beclin 1	Homo sapiens	173-181
30883849-5	2019	This anti-metastatic effect of XAG was due to induction of autophagy, because treatment with the autophagy inhibitor 3-methyadenine (3-MA) or knockdown of the pro-autophagy Beclin-1 effectively abrogated the XAG-induced suppression of metastasis.	xanthoangelol	208-211	beclin 1	Homo sapiens	173-181
30883849-6	2019	Mechanistically, XAG induced autophagy via activation of the AMPK/mTOR signaling pathway, and XAG treatment dramatically increased the expression of p-AMPK while decreasing p-mTOR expression.	xanthoangelol	17-20	mechanistic target of rapamycin kinase	Homo sapiens	66-70
30883849-6	2019	Mechanistically, XAG induced autophagy via activation of the AMPK/mTOR signaling pathway, and XAG treatment dramatically increased the expression of p-AMPK while decreasing p-mTOR expression.	xanthoangelol	94-97	mechanistic target of rapamycin kinase	Homo sapiens	175-179
30883849-9	2019	Taken together, our results revealed that autophagy via the activation of AMPK/mTOR pathway is essential for the anti-metastatic effect of XAG against HCC.	xanthoangelol	139-142	mechanistic target of rapamycin kinase	Homo sapiens	79-83
31356547-0	2019	Xanthoangelol Prevents Ox-LDL-Induced Endothelial Cell Injury by Activating Nrf2/ARE Signaling.	xanthoangelol	0-13	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
31356547-16	2019	Importantly, blockade of Nrf2 signaling using siRNA or specific inhibitor notably abolished the cytoprotective activities of XAG.	xanthoangelol	125-128	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
30621754-0	2019	Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma.	xanthoangelol	38-51	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-108
30621754-8	2019	Furthermore, XAG treatment induced autophagy in Bel 7402 and SMMC 7721 cells, as evidenced by an increase in autophagy-associated proteins, including LC3B-II, Beclin-1, and Atg5.	xanthoangelol	13-16	beclin 1	Homo sapiens	159-167
30621754-8	2019	Furthermore, XAG treatment induced autophagy in Bel 7402 and SMMC 7721 cells, as evidenced by an increase in autophagy-associated proteins, including LC3B-II, Beclin-1, and Atg5.	xanthoangelol	13-16	autophagy related 5	Homo sapiens	173-177
30621754-9	2019	Interestingly, inhibition of autophagy with 3-MA, Bafilomycin A1 (Baf A1), or siRNA targeting Atg5 effectively enhanced the apoptotic cell ratio in XAG-treated cells, indicating that protective effect of autophagy induced by XAG in HCC.	xanthoangelol	148-151	autophagy related 5	Homo sapiens	94-98
30621754-9	2019	Interestingly, inhibition of autophagy with 3-MA, Bafilomycin A1 (Baf A1), or siRNA targeting Atg5 effectively enhanced the apoptotic cell ratio in XAG-treated cells, indicating that protective effect of autophagy induced by XAG in HCC.	xanthoangelol	225-228	autophagy related 5	Homo sapiens	94-98
30621754-10	2019	Moreover, autophagy induced by XAG was mediated by activating endoplasmic reticulum stress (ERS), along with administration of XAG, the expression levels of ERS-associated proteins, including CHOP, GRP78, ATF6, p-eIF2alpha, IRE1alpha, and cleaved caspase-12 were significantly increased in HCC cells.	xanthoangelol	31-34	DNA damage inducible transcript 3	Homo sapiens	192-196
30621754-10	2019	Moreover, autophagy induced by XAG was mediated by activating endoplasmic reticulum stress (ERS), along with administration of XAG, the expression levels of ERS-associated proteins, including CHOP, GRP78, ATF6, p-eIF2alpha, IRE1alpha, and cleaved caspase-12 were significantly increased in HCC cells.	xanthoangelol	31-34	heat shock protein family A (Hsp70) member 5	Homo sapiens	198-203
30621754-10	2019	Moreover, autophagy induced by XAG was mediated by activating endoplasmic reticulum stress (ERS), along with administration of XAG, the expression levels of ERS-associated proteins, including CHOP, GRP78, ATF6, p-eIF2alpha, IRE1alpha, and cleaved caspase-12 were significantly increased in HCC cells.	xanthoangelol	31-34	activating transcription factor 6	Homo sapiens	205-209
30621754-10	2019	Moreover, autophagy induced by XAG was mediated by activating endoplasmic reticulum stress (ERS), along with administration of XAG, the expression levels of ERS-associated proteins, including CHOP, GRP78, ATF6, p-eIF2alpha, IRE1alpha, and cleaved caspase-12 were significantly increased in HCC cells.	xanthoangelol	31-34	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	224-233
30621754-11	2019	Meanwhile, suppressing ERS with chemical chaperones (TUDCA) or CHOP shRNA could effectively abrogate the autophagy-inducing effect of XAG, and increase the apoptotic cell death.	xanthoangelol	134-137	DNA damage inducible transcript 3	Homo sapiens	63-67
30621754-12	2019	Further mechanistic studies showed that ERS-induced autophagy in XAG-treated cells was mediated by activation of JNK/c-jun pathway.	xanthoangelol	65-68	mitogen-activated protein kinase 8	Homo sapiens	113-116
30621754-12	2019	Further mechanistic studies showed that ERS-induced autophagy in XAG-treated cells was mediated by activation of JNK/c-jun pathway.	xanthoangelol	65-68	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-122
30621754-13	2019	XAG treatment resulted in the increase of p-JNK and p-c-jun, while suppressing ERS with TUDCA or CHOP shRNA could effectively reverse it.	xanthoangelol	0-3	mitogen-activated protein kinase 8	Homo sapiens	44-47
30621754-13	2019	XAG treatment resulted in the increase of p-JNK and p-c-jun, while suppressing ERS with TUDCA or CHOP shRNA could effectively reverse it.	xanthoangelol	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	54-59
30621754-14	2019	Meanwhile, SP600125, a JNK inhibitor, effectively reversed XAG-induced protective autophagy and enhanced cell apoptosis in XAG-treated HCC cells.	xanthoangelol	59-62	mitogen-activated protein kinase 8	Homo sapiens	23-26
30621754-14	2019	Meanwhile, SP600125, a JNK inhibitor, effectively reversed XAG-induced protective autophagy and enhanced cell apoptosis in XAG-treated HCC cells.	xanthoangelol	123-126	mitogen-activated protein kinase 8	Homo sapiens	23-26
20938990-0	2011	Prenylated chalcones 4-hydroxyderricin and xanthoangelol stimulate glucose uptake in skeletal muscle cells by inducing GLUT4 translocation.	xanthoangelol	43-56	solute carrier family 2 member 4	Rattus norvegicus	119-124
29980517-0	2018	The Ashitaba (Angelica keiskei) Chalcones 4-hydroxyderricin and Xanthoangelol Suppress Melanomagenesis By Targeting BRAF and PI3K.	xanthoangelol	64-77	Braf transforming gene	Mus musculus	116-120
26141763-9	2015	In addition, xanthoangelol (10, 25 or 50 muM) and 4-hydroxyderricin (5, 10, 25 or 50 muM) inhibited the production of IL-10 and monocyte chemoattractant protein (MCP)-1 in M2-polarized macrophages.	xanthoangelol	13-26	interleukin 10	Mus musculus	118-123
26141763-9	2015	In addition, xanthoangelol (10, 25 or 50 muM) and 4-hydroxyderricin (5, 10, 25 or 50 muM) inhibited the production of IL-10 and monocyte chemoattractant protein (MCP)-1 in M2-polarized macrophages.	xanthoangelol	13-26	chemokine (C-C motif) ligand 2	Mus musculus	128-168
26141763-11	2015	Furthermore, xanthoangelol (5-50 muM) inhibited the phosphorylation of Stat 3 without affecting the expression of the Stat 3 protein in the differentiation process of M2 macrophages, which indicated that these chalcones inhibited the differentiation of M2 macrophages.	xanthoangelol	13-26	signal transducer and activator of transcription 3	Mus musculus	71-77
22038782-5	2011	We also found that xanthoangelol, xanthoangelols B and D, the components of Ashitaba exudates, significantly inhibited TNFalpha-induced PAI-1 production from human umbilical vein endothelial cells (HUVECs).	xanthoangelol	19-32	tumor necrosis factor	Homo sapiens	119-127
22038782-5	2011	We also found that xanthoangelol, xanthoangelols B and D, the components of Ashitaba exudates, significantly inhibited TNFalpha-induced PAI-1 production from human umbilical vein endothelial cells (HUVECs).	xanthoangelol	19-32	serpin family E member 1	Homo sapiens	136-141
18379052-5	2008	Here we show that xanthoangelol triggers oxidative stress by generation of reactive oxygen species and induces apoptosis through release of cytochrome c and activation of caspase-9 in IMR-32 cells.	xanthoangelol	18-31	cytochrome c, somatic	Homo sapiens	140-152
18379052-5	2008	Here we show that xanthoangelol triggers oxidative stress by generation of reactive oxygen species and induces apoptosis through release of cytochrome c and activation of caspase-9 in IMR-32 cells.	xanthoangelol	18-31	caspase 9	Homo sapiens	171-180
18379052-7	2008	Proteomic analysis using 2-dimensional electrophoresis and MALDI-TOF-MS revealed that DJ-1 protein was involved in xanthoangelol-induced apoptosis.	xanthoangelol	115-128	Parkinsonism associated deglycase	Homo sapiens	86-90
18379052-9	2008	Furthermore, DJ-1 was down-regulated by xanthoangelol, leading to loss of antioxidant function and acceleration of apoptosis.	xanthoangelol	40-53	Parkinsonism associated deglycase	Homo sapiens	13-17
18379052-11	2008	These findings suggest that xanthoangelol induces apoptosis by increasing reactive oxygen species and targeting DJ-1, and such mechanism may be an effective therapeutic approach for advanced neuroblastoma.	xanthoangelol	28-41	Parkinsonism associated deglycase	Homo sapiens	112-116
17250645-14	2007	In addition, a significant increase in LDL receptor mRNA expression in the 0.10 Xan group may be responsible, at least in part, for the decrease in serum LDL levels in the xanthoangelol-treated rats.	xanthoangelol	172-185	low density lipoprotein receptor	Rattus norvegicus	39-51
17250645-13	2007	Investigation of the hepatic mRNA expression of proteins involved in lipid metabolism indicated that there was a significant increase in peroxisome proliferator-activated receptor (PPAR) alpha mRNA expression associated with the tendency for increases in acyl-coenzyme A (CoA) synthetase and acyl-CoA oxidase mRNA expression in the 0.10 Xan group, which may be responsible, at least in part, for the decrease in hepatic triglyceride content in the xanthoangelol-treated rats.	xanthoangelol	448-461	peroxisome proliferator activated receptor alpha	Rattus norvegicus	137-192
16079483-3	2005	Early apoptosis induced by 4 h incubation with xanthoangelol was detected using flow cytometry after double-staining with annexin V and propidium iodide (PI).	xanthoangelol	47-60	annexin A5	Homo sapiens	122-131
16079483-4	2005	Western blot analysis showed that xanthoangelol markedly reduced the level of precursor caspase-3 and increased the level of cleaved caspase-3, but Bax and Bcl-2 proteins were not affected.	xanthoangelol	34-47	caspase 3	Homo sapiens	88-97
16079483-4	2005	Western blot analysis showed that xanthoangelol markedly reduced the level of precursor caspase-3 and increased the level of cleaved caspase-3, but Bax and Bcl-2 proteins were not affected.	xanthoangelol	34-47	caspase 3	Homo sapiens	133-142
16079483-5	2005	These results suggest that xanthoangelol induces apoptotic cell death by activatation of caspase-3 in neuroblastoma and leukemia cells through a mechanism that does not involve Bax/Bcl-2 signal transduction.	xanthoangelol	27-40	caspase 3	Homo sapiens	89-98