PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 34547513-5 2022 We identified the carotenoid cleavage products, i.e., apocarotenoids, beta-apo-11-carotenal, 9-cis-beta-apo-11-carotenal, 3-OH-beta-apo-11-carotenal, and 9-cis-3-OH-beta-apo-11-carotenal as intermediates of this ABA1-independent ABA biosynthetic pathway. apocarotenoids 54-68 zeaxanthin epoxidase (ZEP) (ABA1) Arabidopsis thaliana 212-216 34672564-4 2021 Consequently, we found that the apocarotenoids 3-hydroxy-beta-ionone (1) and apo-13-zeaxanthinones (2a/2b) significantly repressed expression of IL-1beta (9.5 +- 1.5 and 28.7 +- 0.6%, respectively) and IL-6 (10.1 +- 0.7 and 6.1 +- 0.4%, respectively) at 10 mug/mL (p < 0.05) using RAW 264.7 mouse macrophages. apocarotenoids 32-46 interleukin 1 alpha Mus musculus 145-153 34672564-4 2021 Consequently, we found that the apocarotenoids 3-hydroxy-beta-ionone (1) and apo-13-zeaxanthinones (2a/2b) significantly repressed expression of IL-1beta (9.5 +- 1.5 and 28.7 +- 0.6%, respectively) and IL-6 (10.1 +- 0.7 and 6.1 +- 0.4%, respectively) at 10 mug/mL (p < 0.05) using RAW 264.7 mouse macrophages. apocarotenoids 32-46 interleukin 6 Mus musculus 202-206 33600157-8 2021 Mice deficient for BCO2 accumulated apocarotenoids in their livers, indicating that the enzyme engages in apocarotenoid metabolism. apocarotenoids 36-50 beta-carotene oxygenase 2 Mus musculus 19-23 34832893-7 2021 Glycopeptide conjugates show dual inhibitory action, while apocarotenoids have mostly cathepsin B and L affinity. apocarotenoids 59-73 cathepsin B Homo sapiens 86-97 27402384-4 2016 Here, we show that SWS2 cone spectral tuning is mediated by modulating the ratio of two apocarotenoids, galloxanthin and 11",12"-dihydrogalloxanthin, which act as intracellular spectral filters in this cell type. apocarotenoids 88-102 EF-hand domain family member D1 Homo sapiens 19-23 32873706-0 2020 The human mitochondrial enzyme BCO2 exhibits catalytic activity towards carotenoids and apocarotenoids. apocarotenoids 88-102 beta-carotene oxygenase 2 Homo sapiens 31-35 31891208-1 2020 SCOPE: beta-Cryptoxanthin (BCX) can be cleaved by both beta-carotene 15,15"-oxygenase (BCO1) and beta-carotene 9",10"-oxygenase (BCO2), generating biological active vitamin A and apocarotenoids. apocarotenoids 179-193 beta-carotene oxygenase 1 Mus musculus 87-91 31891208-1 2020 SCOPE: beta-Cryptoxanthin (BCX) can be cleaved by both beta-carotene 15,15"-oxygenase (BCO1) and beta-carotene 9",10"-oxygenase (BCO2), generating biological active vitamin A and apocarotenoids. apocarotenoids 179-193 beta-carotene oxygenase 2 Mus musculus 129-133 18285342-4 2008 Here we systematically analyzed volatile apocarotenoids generated by maize CCD1 (ZmCCD1) from multiple carotenoid substrates. apocarotenoids 41-55 white cap1 Zea mays 75-79 26187443-2 2016 The preliminary screening results indicated that apocarotenoids inhibited tyrosinase activity in a dose-dependent manner. apocarotenoids 49-63 tyrosinase Mus musculus 74-84 26187443-3 2016 Kinetic analysis revealed that apocarotenoids reversibly inhibited tyrosinase activity. apocarotenoids 31-45 tyrosinase Mus musculus 67-77 26187443-5 2016 Further, molecular docking results implied that apocarotenoids were allosterically bound to tyrosinase through hydrophobic interactions. apocarotenoids 48-62 tyrosinase Mus musculus 92-102 26187443-7 2016 Our results suggested that apocarotenoids could form the basis for the design of novel tyrosinase inhibitors. apocarotenoids 27-41 tyrosinase Mus musculus 87-97 25480008-8 2015 We show here that the biosynthesis of apocarotenoids during AM symbiosis is finely regulated throughout the entire process at the gene expression level, and that CCD7 constitutes a key player in this regulation. apocarotenoids 38-52 carotenoid cleavage dioxygenase 7 Solanum lycopersicum 162-166 26187443-1 2016 In this present study, the inhibitory mechanism of three selected apocarotenoids (bixin, norbixin and crocin) on the diphenolase activity of tyrosinase has been investigated. apocarotenoids 66-80 tyrosinase Mus musculus 141-151 18716794-0 2008 Cloning and characterisation of a maize carotenoid cleavage dioxygenase (ZmCCD1) and its involvement in the biosynthesis of apocarotenoids with various roles in mutualistic and parasitic interactions. apocarotenoids 124-138 white cap1 Zea mays 73-79 18285342-4 2008 Here we systematically analyzed volatile apocarotenoids generated by maize CCD1 (ZmCCD1) from multiple carotenoid substrates. apocarotenoids 41-55 white cap1 Zea mays 81-87