PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34547513-5	2022	We identified the carotenoid cleavage products, i.e., apocarotenoids, beta-apo-11-carotenal, 9-cis-beta-apo-11-carotenal, 3-OH-beta-apo-11-carotenal, and 9-cis-3-OH-beta-apo-11-carotenal as intermediates of this ABA1-independent ABA biosynthetic pathway.	apocarotenoids	54-68	zeaxanthin epoxidase (ZEP) (ABA1)	Arabidopsis thaliana	212-216
34672564-4	2021	Consequently, we found that the apocarotenoids 3-hydroxy-beta-ionone (1) and apo-13-zeaxanthinones (2a/2b) significantly repressed expression of IL-1beta (9.5 +- 1.5 and 28.7 +- 0.6%, respectively) and IL-6 (10.1 +- 0.7 and 6.1 +- 0.4%, respectively) at 10 mug/mL (p < 0.05) using RAW 264.7 mouse macrophages.	apocarotenoids	32-46	interleukin 1 alpha	Mus musculus	145-153
34672564-4	2021	Consequently, we found that the apocarotenoids 3-hydroxy-beta-ionone (1) and apo-13-zeaxanthinones (2a/2b) significantly repressed expression of IL-1beta (9.5 +- 1.5 and 28.7 +- 0.6%, respectively) and IL-6 (10.1 +- 0.7 and 6.1 +- 0.4%, respectively) at 10 mug/mL (p < 0.05) using RAW 264.7 mouse macrophages.	apocarotenoids	32-46	interleukin 6	Mus musculus	202-206
33600157-8	2021	Mice deficient for BCO2 accumulated apocarotenoids in their livers, indicating that the enzyme engages in apocarotenoid metabolism.	apocarotenoids	36-50	beta-carotene oxygenase 2	Mus musculus	19-23
34832893-7	2021	Glycopeptide conjugates show dual inhibitory action, while apocarotenoids have mostly cathepsin B and L affinity.	apocarotenoids	59-73	cathepsin B	Homo sapiens	86-97
27402384-4	2016	Here, we show that SWS2 cone spectral tuning is mediated by modulating the ratio of two apocarotenoids, galloxanthin and 11",12"-dihydrogalloxanthin, which act as intracellular spectral filters in this cell type.	apocarotenoids	88-102	EF-hand domain family member D1	Homo sapiens	19-23
32873706-0	2020	The human mitochondrial enzyme BCO2 exhibits catalytic activity towards carotenoids and apocarotenoids.	apocarotenoids	88-102	beta-carotene oxygenase 2	Homo sapiens	31-35
31891208-1	2020	SCOPE: beta-Cryptoxanthin (BCX) can be cleaved by both beta-carotene 15,15"-oxygenase (BCO1) and beta-carotene 9",10"-oxygenase (BCO2), generating biological active vitamin A and apocarotenoids.	apocarotenoids	179-193	beta-carotene oxygenase 1	Mus musculus	87-91
31891208-1	2020	SCOPE: beta-Cryptoxanthin (BCX) can be cleaved by both beta-carotene 15,15"-oxygenase (BCO1) and beta-carotene 9",10"-oxygenase (BCO2), generating biological active vitamin A and apocarotenoids.	apocarotenoids	179-193	beta-carotene oxygenase 2	Mus musculus	129-133
18285342-4	2008	Here we systematically analyzed volatile apocarotenoids generated by maize CCD1 (ZmCCD1) from multiple carotenoid substrates.	apocarotenoids	41-55	white cap1	Zea mays	75-79
26187443-2	2016	The preliminary screening results indicated that apocarotenoids inhibited tyrosinase activity in a dose-dependent manner.	apocarotenoids	49-63	tyrosinase	Mus musculus	74-84
26187443-3	2016	Kinetic analysis revealed that apocarotenoids reversibly inhibited tyrosinase activity.	apocarotenoids	31-45	tyrosinase	Mus musculus	67-77
26187443-5	2016	Further, molecular docking results implied that apocarotenoids were allosterically bound to tyrosinase through hydrophobic interactions.	apocarotenoids	48-62	tyrosinase	Mus musculus	92-102
26187443-7	2016	Our results suggested that apocarotenoids could form the basis for the design of novel tyrosinase inhibitors.	apocarotenoids	27-41	tyrosinase	Mus musculus	87-97
25480008-8	2015	We show here that the biosynthesis of apocarotenoids during AM symbiosis is finely regulated throughout the entire process at the gene expression level, and that CCD7 constitutes a key player in this regulation.	apocarotenoids	38-52	carotenoid cleavage dioxygenase 7	Solanum lycopersicum	162-166
26187443-1	2016	In this present study, the inhibitory mechanism of three selected apocarotenoids (bixin, norbixin and crocin) on the diphenolase activity of tyrosinase has been investigated.	apocarotenoids	66-80	tyrosinase	Mus musculus	141-151
18716794-0	2008	Cloning and characterisation of a maize carotenoid cleavage dioxygenase (ZmCCD1) and its involvement in the biosynthesis of apocarotenoids with various roles in mutualistic and parasitic interactions.	apocarotenoids	124-138	white cap1	Zea mays	73-79
18285342-4	2008	Here we systematically analyzed volatile apocarotenoids generated by maize CCD1 (ZmCCD1) from multiple carotenoid substrates.	apocarotenoids	41-55	white cap1	Zea mays	81-87