PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33758275-6 2021 Of particular interest was the synergistic effect observed when YHO-1701 was combined with imatinib or dasatinib [breakpoint cluster region-abelson (BCR-ABL) inhibitors], osimertinib [epidermal growth factor receptor (EGFR) inhibitor], crizotinib, alectinib, or ceritinib [anaplastic lymphoma kinase (ALK) inhibitors]. yho-1701 64-72 epidermal growth factor receptor Mus musculus 184-216 33758275-6 2021 Of particular interest was the synergistic effect observed when YHO-1701 was combined with imatinib or dasatinib [breakpoint cluster region-abelson (BCR-ABL) inhibitors], osimertinib [epidermal growth factor receptor (EGFR) inhibitor], crizotinib, alectinib, or ceritinib [anaplastic lymphoma kinase (ALK) inhibitors]. yho-1701 64-72 epidermal growth factor receptor Mus musculus 218-222 33758275-6 2021 Of particular interest was the synergistic effect observed when YHO-1701 was combined with imatinib or dasatinib [breakpoint cluster region-abelson (BCR-ABL) inhibitors], osimertinib [epidermal growth factor receptor (EGFR) inhibitor], crizotinib, alectinib, or ceritinib [anaplastic lymphoma kinase (ALK) inhibitors]. yho-1701 64-72 anaplastic lymphoma kinase Mus musculus 301-304 33758275-6 2021 Of particular interest was the synergistic effect observed when YHO-1701 was combined with imatinib or dasatinib [breakpoint cluster region-abelson (BCR-ABL) inhibitors], osimertinib [epidermal growth factor receptor (EGFR) inhibitor], crizotinib, alectinib, or ceritinib [anaplastic lymphoma kinase (ALK) inhibitors]. yho-1701 64-72 anaplastic lymphoma kinase Mus musculus 273-299 33758275-8 2021 The combination of YHO-1701 with alectinib resulted in significantly greater antitumor activity without exhibiting body weight loss in an NCI-H2228 [echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion] xenograft mouse model. yho-1701 19-27 echinoderm microtubule associated protein like 4 Mus musculus 149-197 33758275-8 2021 The combination of YHO-1701 with alectinib resulted in significantly greater antitumor activity without exhibiting body weight loss in an NCI-H2228 [echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion] xenograft mouse model. yho-1701 19-27 echinoderm microtubule associated protein like 4 Mus musculus 199-203 33758275-8 2021 The combination of YHO-1701 with alectinib resulted in significantly greater antitumor activity without exhibiting body weight loss in an NCI-H2228 [echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion] xenograft mouse model. yho-1701 19-27 anaplastic lymphoma kinase Mus musculus 205-208 33758275-9 2021 Our results strongly suggest that the logical strategy in combination with the novel STAT3 inhibitor YHO-1701 and other mechanistically different targeted agents, could be a promising approach in future clinical settings. yho-1701 101-109 signal transducer and activator of transcription 3 Mus musculus 85-90