PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34855308-3	2022	Furthermore, compound 11b showed 21-fold higher potency than lead compound 2 and 17-fold higher subtype selectivity for D2R over D4R, indicating that the optimal length of spacer affects the D2R functionality.	11b	22-25	dopamine receptor D2	Homo sapiens	120-123
9112813-8	1997	All of the compounds investigated, except for 11b (X = 3-NO2, R = -CH2CH2+NMe3 I-, Kp = 0.15), are lipophilic with n-octanol/aqueous phosphate buffer (pH = 7.4) partition coefficients (Kp) in the 121-424 range relative to the reference drug nimodipine (Kp = 187).	11b	46-49	NME/NM23 nucleoside diphosphate kinase 3	Mus musculus	74-78
8831768-6	1996	Since interaction with the serotonin transporter may modulate the pharmacological effects resulting from binding to the dopamine transporter, 3 beta-(4"-isopropenylphenyl)tropane-2 beta-carboxylic acid methyl ester (11b) which has good affinity for both the 5-HT and DA transporters but low affinity at the NE transporter may be useful for studying this interaction.	11b	216-219	solute carrier family 6 member 4	Homo sapiens	27-48
8417830-4	1993	11B cells demonstrated motility in response to soluble TSP with a maximal effect observed at 1 microM TSP.	11b	0-3	thrombospondin 1	Homo sapiens	55-58
8417830-4	1993	11B cells demonstrated motility in response to soluble TSP with a maximal effect observed at 1 microM TSP.	11b	0-3	thrombospondin 1	Homo sapiens	102-105
34855308-3	2022	Furthermore, compound 11b showed 21-fold higher potency than lead compound 2 and 17-fold higher subtype selectivity for D2R over D4R, indicating that the optimal length of spacer affects the D2R functionality.	11b	22-25	dopamine receptor D2	Homo sapiens	191-194
34855308-4	2022	Molecular modeling study exhibited that 11b formed an electrostatic interaction and two H-bonds with amino acid ASP114, which contributes significantly to the D2R functional activity.	11b	40-43	dopamine receptor D2	Homo sapiens	159-162
34855308-5	2022	Taken together, we discovered a bitopic ligand 11b as potent D2R agonist, which may be used as a tool compound for further study.	11b	47-50	dopamine receptor D2	Homo sapiens	61-64
32786399-7	2020	The dramatic upfield change in chemical shift of 27.2 ppm in the solution-phase 11B nuclear magnetic resonance spectrum accompanying binding of PBA by MR was consistent with an sp3-hybridized boron, which was also supported by density-functional theory calculations.	11b	80-83	Sp3 transcription factor	Homo sapiens	177-180
34727689-4	2021	Treatment of acute monocytic leukemia NOMO-1 cells with a prodrug of 11b decreased the viability of acute monocytic leukemia cells, increased the level of the FTO substrate N6-methyladenosine in mRNA, and induced upregulation of MYC and downregulation of RARA, which are FTO target genes.	11b	69-72	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	159-162
34727689-4	2021	Treatment of acute monocytic leukemia NOMO-1 cells with a prodrug of 11b decreased the viability of acute monocytic leukemia cells, increased the level of the FTO substrate N6-methyladenosine in mRNA, and induced upregulation of MYC and downregulation of RARA, which are FTO target genes.	11b	69-72	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	229-232
34727689-4	2021	Treatment of acute monocytic leukemia NOMO-1 cells with a prodrug of 11b decreased the viability of acute monocytic leukemia cells, increased the level of the FTO substrate N6-methyladenosine in mRNA, and induced upregulation of MYC and downregulation of RARA, which are FTO target genes.	11b	69-72	retinoic acid receptor alpha	Homo sapiens	255-259
34727689-4	2021	Treatment of acute monocytic leukemia NOMO-1 cells with a prodrug of 11b decreased the viability of acute monocytic leukemia cells, increased the level of the FTO substrate N6-methyladenosine in mRNA, and induced upregulation of MYC and downregulation of RARA, which are FTO target genes.	11b	69-72	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	271-274
34080112-6	2022	Molecular docking results unclose the rationale for the interaction of the compound 11b with COX-2 enzyme.	11b	84-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
34080112-7	2022	Further studies revealed that compound 11b exhibited effective COX-2 inhibitory activity, with half-maximal inhibitor concentration (IC50) value of 1.16 microM and selectivity index (SI = 64.66) value close to that of celecoxib (IC50 = 0.93 microM, SI = 65.47).	11b	39-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
33687391-8	2021	Interestingly, [B(C2O4)(OH)2 (HOOC-COOH)]- in the latter sample almost completely transformed into [BOB]- anions upon heating of the IL sample at 413 K for 1 hour, as confirmed using both 11B and 13C NMR.	11b	188-191	G protein-coupled receptor 15	Homo sapiens	100-103
32959865-6	2020	Compound 11b was also found to be the most active compound against both EGFRWT and mutant EGFRT790M, exhibiting IC50 values of 0.09 and 4.03 muM, respectively.	11b	9-12	epidermal growth factor receptor	Homo sapiens	72-78
32959865-8	2020	Additionally, compound 11b upregulated the level of caspase-3 by 6.5 fold in HepG-2 when compared with the control.	11b	23-26	caspase 3	Homo sapiens	52-61
34833999-4	2021	Compound 11b showed excellent GPR120 agonistic activity and pharmacokinetic properties, and could reduce the blood glucose of normal mice in a dose-dependent manner.	11b	9-12	free fatty acid receptor 4	Mus musculus	30-36
34833999-7	2021	Molecular simulation illustrated that compound 11b could enter the active site of GPR120 and interact with ARG99.	11b	47-50	free fatty acid receptor 4	Mus musculus	82-88
34833999-7	2021	Molecular simulation illustrated that compound 11b could enter the active site of GPR120 and interact with ARG99.	11b	47-50	transmembrane and tetratricopeptide repeat containing 1	Mus musculus	107-112
34365057-8	2021	In treated MDA-MB-231 breast cell line samples, 11b was found to highly induce caspase-9 level thereby inducing apoptosis.	11b	48-51	caspase 9	Homo sapiens	79-88
34365057-11	2021	Furthermore, compound 11b downregulated EGFR expression as well as the downstream signaling protein p-AKT.	11b	22-25	epidermal growth factor receptor	Homo sapiens	40-44
34365057-11	2021	Furthermore, compound 11b downregulated EGFR expression as well as the downstream signaling protein p-AKT.	11b	22-25	AKT serine/threonine kinase 1	Homo sapiens	102-105
32151835-3	2020	One of these compounds, 11b, displayed greater selectivity toward HDAC6 than other isoform enzymes.	11b	24-27	histone deacetylase 6	Homo sapiens	66-71
32510731-6	2020	Compounds 11b, 11e, and 11c potently inhibited VEGFR-2 at IC50 values of 0.12 +- 0.02, 0.12 +- 0.02, and 0.13 +- 0.02 microM, respectively, which are nearly equipotent as sorafenib IC50 value (0.10 +- 0.02 microM).	11b	10-13	kinase insert domain receptor	Homo sapiens	47-54
30316059-4	2018	Further pharmacological studies showed that 11b induced dysregulations of the Hsp90 clients (Akt and Cdk4), apoptosis, and cell cycle arrested at G0/G1 phase against A549 cells.	11b	44-47	heat shock protein 90 alpha family class A member 1	Homo sapiens	78-83
30956012-4	2019	Furthermore, docking study showed that compound 11b interacted simultaneously not only with active and peripheral sites of AChE, but also with all five regions of BChE active site.	11b	48-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-127
30956012-4	2019	Furthermore, docking study showed that compound 11b interacted simultaneously not only with active and peripheral sites of AChE, but also with all five regions of BChE active site.	11b	48-51	butyrylcholinesterase	Homo sapiens	163-167
31275393-7	2019	11B was chosen as the measuring element for ICP-MS, and the detection identification and quantification limits were severally 0.036 mg L-1 and 0.12 mg L-1.	11b	0-3	immunoglobulin kappa variable 1-16	Homo sapiens	135-138
31275393-7	2019	11B was chosen as the measuring element for ICP-MS, and the detection identification and quantification limits were severally 0.036 mg L-1 and 0.12 mg L-1.	11b	0-3	immunoglobulin kappa variable 1-16	Homo sapiens	151-154
30412794-6	2019	It should be noted that compound 11b was evaluated for its BACE1 inhibitory activity and calculated IC50 = 21.13 microM confirmed desired inhibitory activity.	11b	33-36	beta-secretase 1	Homo sapiens	59-64
30316059-4	2018	Further pharmacological studies showed that 11b induced dysregulations of the Hsp90 clients (Akt and Cdk4), apoptosis, and cell cycle arrested at G0/G1 phase against A549 cells.	11b	44-47	AKT serine/threonine kinase 1	Homo sapiens	93-96
30316059-4	2018	Further pharmacological studies showed that 11b induced dysregulations of the Hsp90 clients (Akt and Cdk4), apoptosis, and cell cycle arrested at G0/G1 phase against A549 cells.	11b	44-47	cyclin dependent kinase 4	Homo sapiens	101-105
17278826-3	2006	In the present work, the (scaled) dose point kernel of boron-11 decay, called 11B-DPK, was calculated by GEANT4 Monte Carlo simulation code.	11b	78-81	TAO kinase 3	Homo sapiens	82-85
28695953-7	2017	Addition of NEt3 attenuated the water and alcohol loss from 5-9 to allow 1H, 13C, 31P, and 11B NMR data to be collected for all the compounds, confirming the determined structures.	11b	91-94	tetraspanin 2	Homo sapiens	12-16
28454848-2	2017	Among them, compound 11b displayed potent acetylcholinesterase (AChE) inhibition (IC50=187nM) and the highest BuChE/AChE selectivity (66.3).	11b	21-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-62
28454848-2	2017	Among them, compound 11b displayed potent acetylcholinesterase (AChE) inhibition (IC50=187nM) and the highest BuChE/AChE selectivity (66.3).	11b	21-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
28454848-2	2017	Among them, compound 11b displayed potent acetylcholinesterase (AChE) inhibition (IC50=187nM) and the highest BuChE/AChE selectivity (66.3).	11b	21-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-120
28325940-6	2017	A tetrahedral boron "ate" complex capable of transferring an organic group to the adjacent sp2 boron within a boronic anhydride intermediate is proposed and preliminary mechanistic studies by MALDI-TOF and 11B NMR support this proposal.	11b	206-209	Sp2 transcription factor	Homo sapiens	91-94
27824144-2	2016	In consideration of the stability of 11B against neutron irradiation and lower induced radio-activation properties, MgB2 superconductor with 11B serving as boron source is an alternative candidate to be used in fusion reactor with severe irradiation environment.	11b	37-40	secretoglobin family 2A member 1	Homo sapiens	116-120
27824144-2	2016	In consideration of the stability of 11B against neutron irradiation and lower induced radio-activation properties, MgB2 superconductor with 11B serving as boron source is an alternative candidate to be used in fusion reactor with severe irradiation environment.	11b	141-144	secretoglobin family 2A member 1	Homo sapiens	116-120
27183709-3	2016	Functional assays demonstrated that 11b acts as an agonist and in A-375 human melanoma cell line is able to lower levels of procaspase-3, thus confirming a potential major role for sigma-2 pure agonists in the treatment of rapid proliferating melanoma cells.	11b	36-39	caspase 3	Homo sapiens	124-136