PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 34424813-7 2021 In conclusion, gastrodin activates the PI3K/Akt pathway by up-regulating the miR-21 expression and promotes the HUVECs angiogenesis. gastrodin 15-24 microRNA 21 Homo sapiens 77-83 34424813-3 2021 We found that treatment of HUVECs with 10 microM and 25 microM gastrodin, and Vascular endothelial growth factor (VEGF) significantly upregulated the miR-21 expression in the cells. gastrodin 63-72 microRNA 21 Homo sapiens 150-156 34685754-7 2021 The therapeutic effects of gastrodin applied not only to SOD1 ALS MNs but also to sporadic ALS MNs and SOD1G93A ALS mice. gastrodin 27-36 superoxide dismutase 1, soluble Mus musculus 57-61 34424813-7 2021 In conclusion, gastrodin activates the PI3K/Akt pathway by up-regulating the miR-21 expression and promotes the HUVECs angiogenesis. gastrodin 15-24 AKT serine/threonine kinase 1 Homo sapiens 44-47 34685754-7 2021 The therapeutic effects of gastrodin applied not only to SOD1 ALS MNs but also to sporadic ALS MNs and SOD1G93A ALS mice. gastrodin 27-36 superoxide dismutase 1, soluble Mus musculus 103-107 34250336-0 2021 Gastrodin Exerts Cardioprotective Action via Inhibition of Insulin-Like Growth Factor Type 2/Insulin-Like Growth Factor Type 2 Receptor Expression in Cardiac Hypertrophy. gastrodin 0-9 insulin-like growth factor 2 Rattus norvegicus 59-92 34603025-5 2021 In vivo, after treatment with gastrodin for 6 weeks, fasting blood glucose levels, blood lipid metabolism, and insulin sensitivity index values were remarkably reduced compared with those of the diabetic control group. gastrodin 30-39 insulin Homo sapiens 111-118 34603025-8 2021 In vitro, gastrodin alleviated insulin resistance by increasing glucose consumption, glucose uptake, and glycogen content in dexamethasone-induced HepG2 cells. gastrodin 10-19 insulin Homo sapiens 31-38 34541406-7 2022 Interestingly, the obvious anti-inflammatory response was observed in 5%Gastrodin/PU by reduced expression of TNF-alpha and iNOS, which also evidenced by the few fibrous capsule formation in the subcutaneous implantation. gastrodin 72-81 tumor necrosis factor Rattus norvegicus 110-119 34541406-7 2022 Interestingly, the obvious anti-inflammatory response was observed in 5%Gastrodin/PU by reduced expression of TNF-alpha and iNOS, which also evidenced by the few fibrous capsule formation in the subcutaneous implantation. gastrodin 72-81 nitric oxide synthase 2 Rattus norvegicus 124-128 34109563-0 2022 Gastrodin Attenuates Lipopolysaccharide-Induced Inflammatory Response and Migration via the Notch-1 Signaling Pathway in Activated Microglia. gastrodin 0-9 notch receptor 1 Rattus norvegicus 92-99 34109563-3 2022 The present study aimed to ascertain if Gastrodin would regulate the Notch signaling pathway involved in microglia activation. gastrodin 40-49 notch receptor 1 Rattus norvegicus 69-74 34109563-7 2022 Gastrodin mimicked the effects of DAPT by inhibiting the LPS-induced expression of IL-1beta, IL-6, IL-23, TNF-alpha and NO. gastrodin 0-9 interleukin 1 alpha Rattus norvegicus 83-91 34109563-7 2022 Gastrodin mimicked the effects of DAPT by inhibiting the LPS-induced expression of IL-1beta, IL-6, IL-23, TNF-alpha and NO. gastrodin 0-9 interleukin 6 Rattus norvegicus 93-97 34109563-7 2022 Gastrodin mimicked the effects of DAPT by inhibiting the LPS-induced expression of IL-1beta, IL-6, IL-23, TNF-alpha and NO. gastrodin 0-9 tumor necrosis factor Rattus norvegicus 106-115 35474551-10 2022 These results demonstrated that gastrodin may be a potential therapeutic target for the prevention of APAP-induced hepatotoxicity via amelioration of the inflammatory response and oxidative stress, inhibition of ERK/JNK MAPK signaling pathways, and activation of Nrf2 expression levels. gastrodin 32-41 mitogen-activated protein kinase 8 Mus musculus 216-219 35474551-10 2022 These results demonstrated that gastrodin may be a potential therapeutic target for the prevention of APAP-induced hepatotoxicity via amelioration of the inflammatory response and oxidative stress, inhibition of ERK/JNK MAPK signaling pathways, and activation of Nrf2 expression levels. gastrodin 32-41 nuclear factor, erythroid derived 2, like 2 Mus musculus 263-267 34250336-0 2021 Gastrodin Exerts Cardioprotective Action via Inhibition of Insulin-Like Growth Factor Type 2/Insulin-Like Growth Factor Type 2 Receptor Expression in Cardiac Hypertrophy. gastrodin 0-9 insulin-like growth factor 2 Rattus norvegicus 93-126 35610010-8 2022 Diosgenin, pennogenin, and gastrodin induced effective binding activities with adenosine receptor a1. gastrodin 27-36 adenosine A1 receptor Rattus norvegicus 79-100 35474551-0 2022 Gastrodin Alleviates Acetaminophen-Induced Liver Injury in a Mouse Model Through Inhibiting MAPK and Enhancing Nrf2 Pathways. gastrodin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 111-115 35474551-7 2022 The results showed that gastrodin treatment ameliorated acute liver injury caused by APAP, as indicated by serum alanine aminotransferase level, hepatic myeloperoxidase activity, and cytokine (TNF-alpha, IL-1beta, and IL-6) production. gastrodin 24-33 tumor necrosis factor Mus musculus 193-202 35474551-7 2022 The results showed that gastrodin treatment ameliorated acute liver injury caused by APAP, as indicated by serum alanine aminotransferase level, hepatic myeloperoxidase activity, and cytokine (TNF-alpha, IL-1beta, and IL-6) production. gastrodin 24-33 interleukin 1 alpha Mus musculus 204-212 35609324-13 2022 In conclusion, the present study suggested that gastrodin has a protective effect on OGD/R-induced R28 cell injury, which is achieved through the activation of the PI3K/AKT/Nrf2 signaling pathway. gastrodin 48-57 AKT serine/threonine kinase 1 Rattus norvegicus 169-172 35474551-7 2022 The results showed that gastrodin treatment ameliorated acute liver injury caused by APAP, as indicated by serum alanine aminotransferase level, hepatic myeloperoxidase activity, and cytokine (TNF-alpha, IL-1beta, and IL-6) production. gastrodin 24-33 interleukin 6 Mus musculus 218-222 35474551-10 2022 These results demonstrated that gastrodin may be a potential therapeutic target for the prevention of APAP-induced hepatotoxicity via amelioration of the inflammatory response and oxidative stress, inhibition of ERK/JNK MAPK signaling pathways, and activation of Nrf2 expression levels. gastrodin 32-41 mitogen-activated protein kinase 1 Mus musculus 212-215 35609324-13 2022 In conclusion, the present study suggested that gastrodin has a protective effect on OGD/R-induced R28 cell injury, which is achieved through the activation of the PI3K/AKT/Nrf2 signaling pathway. gastrodin 48-57 NFE2 like bZIP transcription factor 2 Rattus norvegicus 173-177 35069849-12 2022 To conclude, treatment of MPC5 cells with gastrodin can attenuate HG-induced inflammation, oxidative stress and cell apoptosis by activating the AMPK/Nrf2 signaling pathway. gastrodin 42-51 nuclear factor, erythroid derived 2, like 2 Mus musculus 150-154 35462916-4 2022 Among them, salidroside and gastrodin showed higher relevance with AD targets, such as ESR1 and AR. gastrodin 28-37 estrogen receptor 1 (alpha) Mus musculus 87-91 35462916-4 2022 Among them, salidroside and gastrodin showed higher relevance with AD targets, such as ESR1 and AR. gastrodin 28-37 ferredoxin reductase Mus musculus 96-98 35249878-0 2022 (Gastrodin injection alleviates lung injury caused by focal cerebral ischemia in rats through NGF/TrkA pathway-mediated activation of the anti-inflammatory pathway). gastrodin 1-10 nerve growth factor Rattus norvegicus 94-97 35140620-9 2022 The results of BCA indicated that Gastrodin, Liquiritin, Hesperidin, Isoliquiritin, Hesperetin, and Isoliquiritigenin might be the active constituents to activate ROS and suppress hs-CRP as determined by spectrum-effect relationships. gastrodin 34-43 C-reactive protein Homo sapiens 183-186 35249878-8 2022 CONCLUSION: The NGF/TrkA pathway may participate in cerebral ischemia-induced inflammatory lung injury, which can be obviously alleviated by gastrodin through the activation of the anti-inflammatory pathway mediated by the NGF/TrkA pathway. gastrodin 141-150 nerve growth factor Rattus norvegicus 16-19 35249878-8 2022 CONCLUSION: The NGF/TrkA pathway may participate in cerebral ischemia-induced inflammatory lung injury, which can be obviously alleviated by gastrodin through the activation of the anti-inflammatory pathway mediated by the NGF/TrkA pathway. gastrodin 141-150 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 20-24 35249878-8 2022 CONCLUSION: The NGF/TrkA pathway may participate in cerebral ischemia-induced inflammatory lung injury, which can be obviously alleviated by gastrodin through the activation of the anti-inflammatory pathway mediated by the NGF/TrkA pathway. gastrodin 141-150 nerve growth factor Rattus norvegicus 223-226 35249878-8 2022 CONCLUSION: The NGF/TrkA pathway may participate in cerebral ischemia-induced inflammatory lung injury, which can be obviously alleviated by gastrodin through the activation of the anti-inflammatory pathway mediated by the NGF/TrkA pathway. gastrodin 141-150 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 227-231 35249878-0 2022 (Gastrodin injection alleviates lung injury caused by focal cerebral ischemia in rats through NGF/TrkA pathway-mediated activation of the anti-inflammatory pathway). gastrodin 1-10 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 98-102 35249878-1 2022 OBJECTIVE: To investigate the therapeutic mechanism of gastrodin injection for alleviating lung injury caused by focal cerebral ischemia in rats and the role of the NGF-TrkA pathway in mediating this effect. gastrodin 55-64 nerve growth factor Rattus norvegicus 165-168 35249878-1 2022 OBJECTIVE: To investigate the therapeutic mechanism of gastrodin injection for alleviating lung injury caused by focal cerebral ischemia in rats and the role of the NGF-TrkA pathway in mediating this effect. gastrodin 55-64 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 169-173 35249878-7 2022 Treatment with gastrodin injection obviously alleviated lung inflammation, decreased the wet/dry weight ratio of the lungs (P < 0.05), and significantly lowered TNF-alpha level (P < 0.01) and increased IL-10 level in the arterial blood in the rat models (P < 0.01); gastrodin injection also significantly decreased the protein expressions of NF-kappaB p65 and TNF-alpha (P < 0.05) and up-regulated the expressions of NGF and TrkA in the lung tissue of the rats (P < 0.05). gastrodin 15-24 tumor necrosis factor Rattus norvegicus 161-170 35249878-7 2022 Treatment with gastrodin injection obviously alleviated lung inflammation, decreased the wet/dry weight ratio of the lungs (P < 0.05), and significantly lowered TNF-alpha level (P < 0.01) and increased IL-10 level in the arterial blood in the rat models (P < 0.01); gastrodin injection also significantly decreased the protein expressions of NF-kappaB p65 and TNF-alpha (P < 0.05) and up-regulated the expressions of NGF and TrkA in the lung tissue of the rats (P < 0.05). gastrodin 15-24 interleukin 10 Rattus norvegicus 202-207 35249878-7 2022 Treatment with gastrodin injection obviously alleviated lung inflammation, decreased the wet/dry weight ratio of the lungs (P < 0.05), and significantly lowered TNF-alpha level (P < 0.01) and increased IL-10 level in the arterial blood in the rat models (P < 0.01); gastrodin injection also significantly decreased the protein expressions of NF-kappaB p65 and TNF-alpha (P < 0.05) and up-regulated the expressions of NGF and TrkA in the lung tissue of the rats (P < 0.05). gastrodin 15-24 tumor necrosis factor Rattus norvegicus 360-369 35249878-7 2022 Treatment with gastrodin injection obviously alleviated lung inflammation, decreased the wet/dry weight ratio of the lungs (P < 0.05), and significantly lowered TNF-alpha level (P < 0.01) and increased IL-10 level in the arterial blood in the rat models (P < 0.01); gastrodin injection also significantly decreased the protein expressions of NF-kappaB p65 and TNF-alpha (P < 0.05) and up-regulated the expressions of NGF and TrkA in the lung tissue of the rats (P < 0.05). gastrodin 15-24 nerve growth factor Rattus norvegicus 417-420 35249878-7 2022 Treatment with gastrodin injection obviously alleviated lung inflammation, decreased the wet/dry weight ratio of the lungs (P < 0.05), and significantly lowered TNF-alpha level (P < 0.01) and increased IL-10 level in the arterial blood in the rat models (P < 0.01); gastrodin injection also significantly decreased the protein expressions of NF-kappaB p65 and TNF-alpha (P < 0.05) and up-regulated the expressions of NGF and TrkA in the lung tissue of the rats (P < 0.05). gastrodin 15-24 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 425-429 35051947-10 2022 Moreover, gastrodin-treated rats exhibited a dramatic reduction in renal tubular apoptosis, along with a decrease in caspase-3 activation and an increase in the Bcl-2/Bax ratio. gastrodin 10-19 caspase 3 Rattus norvegicus 117-126 35051947-10 2022 Moreover, gastrodin-treated rats exhibited a dramatic reduction in renal tubular apoptosis, along with a decrease in caspase-3 activation and an increase in the Bcl-2/Bax ratio. gastrodin 10-19 BCL2, apoptosis regulator Rattus norvegicus 161-166 35051947-10 2022 Moreover, gastrodin-treated rats exhibited a dramatic reduction in renal tubular apoptosis, along with a decrease in caspase-3 activation and an increase in the Bcl-2/Bax ratio. gastrodin 10-19 BCL2 associated X, apoptosis regulator Rattus norvegicus 167-170 33704382-8 2021 Moreover, the administration of gastrodin also suppressed the levels of BDNF and NGF, and activated the AMPK/PPARalpha pathway. gastrodin 32-41 brain-derived neurotrophic factor Rattus norvegicus 72-76 33704382-8 2021 Moreover, the administration of gastrodin also suppressed the levels of BDNF and NGF, and activated the AMPK/PPARalpha pathway. gastrodin 32-41 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 104-108 33704382-8 2021 Moreover, the administration of gastrodin also suppressed the levels of BDNF and NGF, and activated the AMPK/PPARalpha pathway. gastrodin 32-41 peroxisome proliferator activated receptor alpha Rattus norvegicus 109-118 30554535-2 2021 Administration of gastrodin can relieve chronic pain to cancer patients with CIPN and attenuated the inflammatory response by reducing the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). gastrodin 18-27 tumor necrosis factor Homo sapiens 153-180 33613977-8 2021 Pretreatment with gastrodin significantly increased the levels of EB and fluorescein sodium in the tree shrew cerebral cortex and increased the expressions of occluding, ZO1, JAMA, and GLUT1 and GLUT. gastrodin 18-27 solute carrier family 2 member 1 Homo sapiens 185-190 30554535-2 2021 Administration of gastrodin can relieve chronic pain to cancer patients with CIPN and attenuated the inflammatory response by reducing the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). gastrodin 18-27 tumor necrosis factor Homo sapiens 182-191 30554535-2 2021 Administration of gastrodin can relieve chronic pain to cancer patients with CIPN and attenuated the inflammatory response by reducing the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). gastrodin 18-27 interleukin 6 Homo sapiens 197-210 30554535-2 2021 Administration of gastrodin can relieve chronic pain to cancer patients with CIPN and attenuated the inflammatory response by reducing the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). gastrodin 18-27 interleukin 6 Homo sapiens 212-216 30554535-7 2021 Gastrodin relieved CIPN by inhibiting activation of spinal microglia through Fractalkine (CX3CL1) and its receptor CX3CR1, then inhibited P38/mitogen-activated protein kinase (MAPK) signaling pathway and reduced the expression of inflammatory factor TNF-alpha and interleukin-1beta (IL-1beta). gastrodin 0-9 C-X3-C motif chemokine ligand 1 Homo sapiens 77-88 30554535-7 2021 Gastrodin relieved CIPN by inhibiting activation of spinal microglia through Fractalkine (CX3CL1) and its receptor CX3CR1, then inhibited P38/mitogen-activated protein kinase (MAPK) signaling pathway and reduced the expression of inflammatory factor TNF-alpha and interleukin-1beta (IL-1beta). gastrodin 0-9 C-X3-C motif chemokine ligand 1 Homo sapiens 90-96 30554535-7 2021 Gastrodin relieved CIPN by inhibiting activation of spinal microglia through Fractalkine (CX3CL1) and its receptor CX3CR1, then inhibited P38/mitogen-activated protein kinase (MAPK) signaling pathway and reduced the expression of inflammatory factor TNF-alpha and interleukin-1beta (IL-1beta). gastrodin 0-9 C-X3-C motif chemokine receptor 1 Homo sapiens 115-121 30554535-7 2021 Gastrodin relieved CIPN by inhibiting activation of spinal microglia through Fractalkine (CX3CL1) and its receptor CX3CR1, then inhibited P38/mitogen-activated protein kinase (MAPK) signaling pathway and reduced the expression of inflammatory factor TNF-alpha and interleukin-1beta (IL-1beta). gastrodin 0-9 mitogen-activated protein kinase 14 Homo sapiens 138-174 30554535-7 2021 Gastrodin relieved CIPN by inhibiting activation of spinal microglia through Fractalkine (CX3CL1) and its receptor CX3CR1, then inhibited P38/mitogen-activated protein kinase (MAPK) signaling pathway and reduced the expression of inflammatory factor TNF-alpha and interleukin-1beta (IL-1beta). gastrodin 0-9 mitogen-activated protein kinase 14 Homo sapiens 176-180 30554535-7 2021 Gastrodin relieved CIPN by inhibiting activation of spinal microglia through Fractalkine (CX3CL1) and its receptor CX3CR1, then inhibited P38/mitogen-activated protein kinase (MAPK) signaling pathway and reduced the expression of inflammatory factor TNF-alpha and interleukin-1beta (IL-1beta). gastrodin 0-9 tumor necrosis factor Homo sapiens 250-259 30554535-7 2021 Gastrodin relieved CIPN by inhibiting activation of spinal microglia through Fractalkine (CX3CL1) and its receptor CX3CR1, then inhibited P38/mitogen-activated protein kinase (MAPK) signaling pathway and reduced the expression of inflammatory factor TNF-alpha and interleukin-1beta (IL-1beta). gastrodin 0-9 interleukin 1 beta Homo sapiens 264-281 30554535-7 2021 Gastrodin relieved CIPN by inhibiting activation of spinal microglia through Fractalkine (CX3CL1) and its receptor CX3CR1, then inhibited P38/mitogen-activated protein kinase (MAPK) signaling pathway and reduced the expression of inflammatory factor TNF-alpha and interleukin-1beta (IL-1beta). gastrodin 0-9 interleukin 1 beta Homo sapiens 283-291 33320446-8 2021 In addition, treatment with gastrodin increased Nrf2 nuclear translocation, thus enhancing the expression of downstream enzymes. gastrodin 28-37 NFE2 like bZIP transcription factor 2 Homo sapiens 48-52 33010109-6 2020 Enhanced expression of Caspase 3, Caspase 9, and Bax and decreased expression of Bcl-2 induced by fluoride were also reversed by gastrodin. gastrodin 129-138 caspase 3 Rattus norvegicus 23-32 32698696-4 2020 It was reported that the herbal extract at a Panax ginseng extract to Gastrodia elata extract ratio of 1:10 (w/w) and the compound mixture with equal proportion of ginsenoside F2 and alpha-gastrodin exhibited significant inhibition of MMP-1 and IL-6 production, and marked upregulation of procollagen type 1 formation. gastrodin 188-198 matrix metallopeptidase 1 Homo sapiens 235-240 33010109-6 2020 Enhanced expression of Caspase 3, Caspase 9, and Bax and decreased expression of Bcl-2 induced by fluoride were also reversed by gastrodin. gastrodin 129-138 caspase 9 Rattus norvegicus 34-43 33010109-6 2020 Enhanced expression of Caspase 3, Caspase 9, and Bax and decreased expression of Bcl-2 induced by fluoride were also reversed by gastrodin. gastrodin 129-138 BCL2 associated X, apoptosis regulator Rattus norvegicus 49-52 33010109-6 2020 Enhanced expression of Caspase 3, Caspase 9, and Bax and decreased expression of Bcl-2 induced by fluoride were also reversed by gastrodin. gastrodin 129-138 BCL2, apoptosis regulator Rattus norvegicus 81-86 33095377-6 2021 The present results showed that gastrodin markedly suppressed the expression of members of Notch signaling pathway (Notch-1, NICD, RBP-JK and Hes-1) in activated microglia both in vivo and in vitro. gastrodin 32-41 notch receptor 1 Rattus norvegicus 91-96 33095377-6 2021 The present results showed that gastrodin markedly suppressed the expression of members of Notch signaling pathway (Notch-1, NICD, RBP-JK and Hes-1) in activated microglia both in vivo and in vitro. gastrodin 32-41 notch receptor 1 Rattus norvegicus 116-123 33095377-6 2021 The present results showed that gastrodin markedly suppressed the expression of members of Notch signaling pathway (Notch-1, NICD, RBP-JK and Hes-1) in activated microglia both in vivo and in vitro. gastrodin 32-41 hes family bHLH transcription factor 1 Rattus norvegicus 142-147 33095377-9 2021 Treatment with DAPT and gastrodin further decreased NICD and Hes-1 expression. gastrodin 24-33 hes family bHLH transcription factor 1 Rattus norvegicus 61-66 33095377-11 2021 However, Sirt3 expression in activated BV-2 microglia given a combined DAPT and gastrodin treatment was not further increased. gastrodin 80-89 sirtuin 3 Rattus norvegicus 9-14 33095377-12 2021 In addition, combination of DAPT and Gastrodin cumulatively decreased tumor necrosis factor-alpha (TNF-alpha) expression. gastrodin 37-46 tumor necrosis factor Rattus norvegicus 70-97 33095377-12 2021 In addition, combination of DAPT and Gastrodin cumulatively decreased tumor necrosis factor-alpha (TNF-alpha) expression. gastrodin 37-46 tumor necrosis factor Rattus norvegicus 99-108 31698019-0 2020 Gastrodin protects against glutamate-induced ferroptosis in HT-22 cells through Nrf2/HO-1 signaling pathway. gastrodin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 80-84 32473572-0 2020 The improvement effect of gastrodin on LPS/GalN-induced fulminant hepatitis via inhibiting inflammation and apoptosis and restoring autophagy. gastrodin 26-35 galanin and GMAP prepropeptide Mus musculus 43-47 32473572-3 2020 In the present study, we aimed to evaluate whether GTD treatment could alleviate lipopolysaccharide and d-galactosamine (LPS/GalN)-induced FH in mice and its potential mechanisms. gastrodin 51-54 galanin and GMAP prepropeptide Mus musculus 125-129 32473572-5 2020 In addition, GTD treatment relieved hepatic apoptosis by the regulation of peroxisome proliferator-activated receptors (PPARs), P53 and caspase-3/9. gastrodin 13-16 transformation related protein 53, pseudogene Mus musculus 128-131 32473572-5 2020 In addition, GTD treatment relieved hepatic apoptosis by the regulation of peroxisome proliferator-activated receptors (PPARs), P53 and caspase-3/9. gastrodin 13-16 caspase 3 Mus musculus 136-147 32473572-6 2020 Furthermore, GTD treatment could significantly inhibit inflammation-related signaling pathways activated by LPS/GalN, including the suppression of nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) activation. gastrodin 13-16 galanin and GMAP prepropeptide Mus musculus 112-116 32473572-6 2020 Furthermore, GTD treatment could significantly inhibit inflammation-related signaling pathways activated by LPS/GalN, including the suppression of nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) activation. gastrodin 13-16 NLR family, pyrin domain containing 3 Mus musculus 204-209 32473572-6 2020 Furthermore, GTD treatment could significantly inhibit inflammation-related signaling pathways activated by LPS/GalN, including the suppression of nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) activation. gastrodin 13-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 215-237 32473572-6 2020 Furthermore, GTD treatment could significantly inhibit inflammation-related signaling pathways activated by LPS/GalN, including the suppression of nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) activation. gastrodin 13-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 239-248 32473572-8 2020 Taken together, our investigation indicated that GTD played an essential role in liver protection by relieving hepatocyte apoptosis and inflammation reaction, which may be closely involved in the inhibition of NLRP3 inflammasome and NF-kappaB activation, regulation of apoptosis-related proteins expression, and the recovery of AMPK/ACC/autophagy. gastrodin 49-52 NLR family, pyrin domain containing 3 Mus musculus 210-215 32473572-8 2020 Taken together, our investigation indicated that GTD played an essential role in liver protection by relieving hepatocyte apoptosis and inflammation reaction, which may be closely involved in the inhibition of NLRP3 inflammasome and NF-kappaB activation, regulation of apoptosis-related proteins expression, and the recovery of AMPK/ACC/autophagy. gastrodin 49-52 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 233-242 31698019-0 2020 Gastrodin protects against glutamate-induced ferroptosis in HT-22 cells through Nrf2/HO-1 signaling pathway. gastrodin 0-9 heme oxygenase 1 Mus musculus 85-89 31698019-5 2020 Results showed that GAS inhibited glutamate-induced ferroptosis via Nrf2/HO-1 signaling pathway. gastrodin 20-23 nuclear factor, erythroid derived 2, like 2 Mus musculus 68-72 31698019-5 2020 Results showed that GAS inhibited glutamate-induced ferroptosis via Nrf2/HO-1 signaling pathway. gastrodin 20-23 heme oxygenase 1 Mus musculus 73-77 31698019-10 2020 We found that GAS increased the nuclear translocation of Nrf2, up-regulated the downstream HO-1 protein expression in HT-22 cells following treatment with glutamate. gastrodin 14-17 nuclear factor, erythroid derived 2, like 2 Mus musculus 57-61 31698019-10 2020 We found that GAS increased the nuclear translocation of Nrf2, up-regulated the downstream HO-1 protein expression in HT-22 cells following treatment with glutamate. gastrodin 14-17 heme oxygenase 1 Mus musculus 91-95 31698019-12 2020 In conclusion, these results show that GAS protects HT-22 cells from the ferroptosis induced by glutamate through a new mechanism of Nrf2/HO-1 signaling pathway. gastrodin 39-42 nuclear factor, erythroid derived 2, like 2 Mus musculus 133-137 31698019-12 2020 In conclusion, these results show that GAS protects HT-22 cells from the ferroptosis induced by glutamate through a new mechanism of Nrf2/HO-1 signaling pathway. gastrodin 39-42 heme oxygenase 1 Mus musculus 138-142 32148791-0 2020 Gastrodin improves preeclampsia-induced cell apoptosis by regulation of TLR4/NF-kappaB in rats. gastrodin 0-9 toll-like receptor 4 Rattus norvegicus 72-76 32148791-9 2020 The positive apoptosis cells and apoptosis rate were significantly decreased with MyD88 and NF-kappaB (p65) proteins depressing in gastrodin-treated groups with dose-dependent (p < .05). gastrodin 131-140 MYD88, innate immune signal transduction adaptor Rattus norvegicus 82-87 32148791-9 2020 The positive apoptosis cells and apoptosis rate were significantly decreased with MyD88 and NF-kappaB (p65) proteins depressing in gastrodin-treated groups with dose-dependent (p < .05). gastrodin 131-140 synaptotagmin 1 Rattus norvegicus 103-106 32148791-10 2020 Gastrodin improves PE-induced cell apoptosis and pathology changed via MyD88/NF-kappaB pathway in vitro and in vivo study. gastrodin 0-9 MYD88, innate immune signal transduction adaptor Rattus norvegicus 71-76 32115506-9 2020 Moreover, gastrodin increased the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), GPX4, ferroportin-1 (FPN1), and heme oxygenase-1 (HO-1) in C6 cells treated with H2O2. gastrodin 10-19 NFE2 like bZIP transcription factor 2 Rattus norvegicus 56-99 32668973-0 2020 Gastrodin Pretreatment Protects Liver Against Ischemia-Reperfusion Injury via Activation of the Nrf2/HO-1 Pathway. gastrodin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 96-100 32668973-0 2020 Gastrodin Pretreatment Protects Liver Against Ischemia-Reperfusion Injury via Activation of the Nrf2/HO-1 Pathway. gastrodin 0-9 heme oxygenase 1 Mus musculus 101-105 32115506-9 2020 Moreover, gastrodin increased the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), GPX4, ferroportin-1 (FPN1), and heme oxygenase-1 (HO-1) in C6 cells treated with H2O2. gastrodin 10-19 NFE2 like bZIP transcription factor 2 Rattus norvegicus 101-105 32115506-9 2020 Moreover, gastrodin increased the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), GPX4, ferroportin-1 (FPN1), and heme oxygenase-1 (HO-1) in C6 cells treated with H2O2. gastrodin 10-19 glutathione peroxidase 4 Rattus norvegicus 108-112 32115506-9 2020 Moreover, gastrodin increased the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), GPX4, ferroportin-1 (FPN1), and heme oxygenase-1 (HO-1) in C6 cells treated with H2O2. gastrodin 10-19 solute carrier family 40 member 1 Rattus norvegicus 114-127 32115506-9 2020 Moreover, gastrodin increased the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), GPX4, ferroportin-1 (FPN1), and heme oxygenase-1 (HO-1) in C6 cells treated with H2O2. gastrodin 10-19 solute carrier family 40 member 1 Rattus norvegicus 129-133 32115506-9 2020 Moreover, gastrodin increased the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), GPX4, ferroportin-1 (FPN1), and heme oxygenase-1 (HO-1) in C6 cells treated with H2O2. gastrodin 10-19 heme oxygenase 1 Rattus norvegicus 140-156 32115506-10 2020 RSL3, a GPX4 inhibitor, inhibited GPX4 protein level in cells co-treated with gastrodin and 100 microM H2O2. gastrodin 78-87 glutathione peroxidase 4 Rattus norvegicus 8-12 32115506-10 2020 RSL3, a GPX4 inhibitor, inhibited GPX4 protein level in cells co-treated with gastrodin and 100 microM H2O2. gastrodin 78-87 glutathione peroxidase 4 Rattus norvegicus 34-38 31727597-9 2020 Moreover, gastrodin administration significantly reduced levels of ROS, 8-OHDG, 3-Nitrotyrosine and MDA, while increased GSH-Px and SOD activity, and stimulated the upregulation of Keap1, Nrf2, and HO-1 signaling at 72 hours post-ICH. gastrodin 10-19 Kelch-like ECH-associated protein 1 Rattus norvegicus 181-186 31769187-9 2020 Meanwhile, p38/JNK and NF-kappaB pathways induced by LPS were repressed by gastrodin. gastrodin 75-84 mitogen-activated protein kinase 14 Homo sapiens 11-14 31769187-9 2020 Meanwhile, p38/JNK and NF-kappaB pathways induced by LPS were repressed by gastrodin. gastrodin 75-84 mitogen-activated protein kinase 8 Homo sapiens 15-18 31727597-9 2020 Moreover, gastrodin administration significantly reduced levels of ROS, 8-OHDG, 3-Nitrotyrosine and MDA, while increased GSH-Px and SOD activity, and stimulated the upregulation of Keap1, Nrf2, and HO-1 signaling at 72 hours post-ICH. gastrodin 10-19 NFE2 like bZIP transcription factor 2 Rattus norvegicus 188-192 31727597-10 2020 Furthermore, gastrodin significantly increased Bcl-2 expression, while reduced level of Bax, active caspase-3 and active caspase-9, also reduced the number of active caspase-3 or TUNEL positive neurons at 72 hours post-ICH. gastrodin 13-22 BCL2, apoptosis regulator Rattus norvegicus 47-52 31727597-10 2020 Furthermore, gastrodin significantly increased Bcl-2 expression, while reduced level of Bax, active caspase-3 and active caspase-9, also reduced the number of active caspase-3 or TUNEL positive neurons at 72 hours post-ICH. gastrodin 13-22 caspase 9 Rattus norvegicus 121-130 31727597-10 2020 Furthermore, gastrodin significantly increased Bcl-2 expression, while reduced level of Bax, active caspase-3 and active caspase-9, also reduced the number of active caspase-3 or TUNEL positive neurons at 72 hours post-ICH. gastrodin 13-22 caspase 3 Rattus norvegicus 166-175 31026457-10 2019 Moreover, treatment with LiCl, a special Wnt/beta-catenin pathway agonist significantly blocked Gastrodin-mediated down-regulation of iNOS, TNF-alpha, cyclin-D1, NO and the number of cells in the G2/M+S phase of cell cycle in LPS-stimulated BV-2 microglia. gastrodin 96-105 Wnt family member 2 Rattus norvegicus 41-44 31610203-9 2019 RESULTS: MCAO-induced tissue infarction, neurological deficits, inflammasome activation, and downregulation of miR-21-5p and miR-331-5p were all mitigated by the combination of gastrodin and rhynchophylline. gastrodin 177-186 microRNA 215 Mus musculus 111-120 31610203-9 2019 RESULTS: MCAO-induced tissue infarction, neurological deficits, inflammasome activation, and downregulation of miR-21-5p and miR-331-5p were all mitigated by the combination of gastrodin and rhynchophylline. gastrodin 177-186 microRNA 331 Mus musculus 125-132 31610203-10 2019 In OGD-treated BV2 cells, the combination of gastrodin and rhynchophylline also alleviated inflammasome activation and restored the expression of miR-21-5p and miR-331-5p. gastrodin 45-54 microRNA 215 Mus musculus 146-155 31610203-10 2019 In OGD-treated BV2 cells, the combination of gastrodin and rhynchophylline also alleviated inflammasome activation and restored the expression of miR-21-5p and miR-331-5p. gastrodin 45-54 microRNA 331 Mus musculus 160-167 31610203-13 2019 Finally, we demonstrated that a miR-21-5p inhibitor and/or a miR-331-5p inhibitor counteracted the protective effects of gastrodin and/or rhynchophylline. gastrodin 121-130 microRNA 215 Mus musculus 32-41 31610203-13 2019 Finally, we demonstrated that a miR-21-5p inhibitor and/or a miR-331-5p inhibitor counteracted the protective effects of gastrodin and/or rhynchophylline. gastrodin 121-130 microRNA 331 Mus musculus 61-68 31610203-14 2019 CONCLUSIONS: The combination of gastrodin and rhynchophylline exerts neuroprotective effects by preventing ischaemia-induced inflammasome activation via upregulating miR-21-5p and miR-331-5p. gastrodin 32-41 microRNA 215 Mus musculus 166-175 31610203-14 2019 CONCLUSIONS: The combination of gastrodin and rhynchophylline exerts neuroprotective effects by preventing ischaemia-induced inflammasome activation via upregulating miR-21-5p and miR-331-5p. gastrodin 32-41 microRNA 331 Mus musculus 180-187 31828147-0 2019 Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB in Rats Receiving Liver Allografts. gastrodin 0-9 Tnf receptor-associated factor 2 Rattus norvegicus 52-57 31828147-7 2019 Expression levels of Caspase-3, Bad, and Bax proteins were decreased, and the expression of the antiapoptotic protein Bcl-2 was increased in the GAS-L and GAS-H groups (P < 0.05). gastrodin 145-148 BCL2, apoptosis regulator Rattus norvegicus 118-123 31828147-7 2019 Expression levels of Caspase-3, Bad, and Bax proteins were decreased, and the expression of the antiapoptotic protein Bcl-2 was increased in the GAS-L and GAS-H groups (P < 0.05). gastrodin 155-158 BCL2, apoptosis regulator Rattus norvegicus 118-123 31828147-8 2019 Mechanistically, the ERS-related IRE1alpha/TRAF2/NF-kappaB pathway was suppressed by GAS, and GAS acted mainly on intrahepatic macrophages to affect AR and reduce ROS production (P < 0.05). gastrodin 85-88 Tnf receptor-associated factor 2 Rattus norvegicus 43-48 31828147-9 2019 Conclusion: GAS ameliorated AR by inhibiting the IRE1alpha/TRAF2/NF-kappaB pathway in LT. gastrodin 12-15 Tnf receptor-associated factor 2 Rattus norvegicus 59-64 31026457-0 2019 Gastrodin attenuates proliferation and inflammatory responses in activated microglia through Wnt/beta-catenin signaling pathway. gastrodin 0-9 Wnt family member 2 Rattus norvegicus 93-96 31026457-0 2019 Gastrodin attenuates proliferation and inflammatory responses in activated microglia through Wnt/beta-catenin signaling pathway. gastrodin 0-9 catenin beta 1 Rattus norvegicus 97-109 31026457-5 2019 Gastrodin inhibited the expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), cyclin-D1 and Ki67 in lipopolysaccharide (LPS)-stimulated BV-2 or primary microglia. gastrodin 0-9 nitric oxide synthase 2 Rattus norvegicus 38-69 31026457-5 2019 Gastrodin inhibited the expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), cyclin-D1 and Ki67 in lipopolysaccharide (LPS)-stimulated BV-2 or primary microglia. gastrodin 0-9 nitric oxide synthase 2 Rattus norvegicus 71-75 31026457-5 2019 Gastrodin inhibited the expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), cyclin-D1 and Ki67 in lipopolysaccharide (LPS)-stimulated BV-2 or primary microglia. gastrodin 0-9 tumor necrosis factor Rattus norvegicus 78-105 31026457-5 2019 Gastrodin inhibited the expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), cyclin-D1 and Ki67 in lipopolysaccharide (LPS)-stimulated BV-2 or primary microglia. gastrodin 0-9 tumor necrosis factor Rattus norvegicus 107-116 31026457-5 2019 Gastrodin inhibited the expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), cyclin-D1 and Ki67 in lipopolysaccharide (LPS)-stimulated BV-2 or primary microglia. gastrodin 0-9 cyclin D1 Rattus norvegicus 119-128 31026457-6 2019 Gastrodin also suppressed the expression of iNOS and Ki67 in activated microglia in three-day-old LPS-injected postnatal rats. gastrodin 0-9 nitric oxide synthase 2 Rattus norvegicus 44-48 31026457-7 2019 In addition, the present results have shown that Gastrodin inhibited LPS-induced phosphorylation of glycogen synthase kinase-3beta (GSK-3beta) at Ser 9 and beta-catenin activity. gastrodin 49-58 glycogen synthase kinase 3 beta Rattus norvegicus 100-130 31026457-7 2019 In addition, the present results have shown that Gastrodin inhibited LPS-induced phosphorylation of glycogen synthase kinase-3beta (GSK-3beta) at Ser 9 and beta-catenin activity. gastrodin 49-58 glycogen synthase kinase 3 beta Rattus norvegicus 132-141 31026457-7 2019 In addition, the present results have shown that Gastrodin inhibited LPS-induced phosphorylation of glycogen synthase kinase-3beta (GSK-3beta) at Ser 9 and beta-catenin activity. gastrodin 49-58 catenin beta 1 Rattus norvegicus 156-168 31749701-9 2019 Mechanistically, we found that GAS protects HUVECs from TBHP-induced cellular apoptosis by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. gastrodin 31-34 NFE2 like bZIP transcription factor 2 Homo sapiens 151-155 31749701-9 2019 Mechanistically, we found that GAS protects HUVECs from TBHP-induced cellular apoptosis by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. gastrodin 31-34 heme oxygenase 1 Homo sapiens 157-173 31749701-9 2019 Mechanistically, we found that GAS protects HUVECs from TBHP-induced cellular apoptosis by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. gastrodin 31-34 heme oxygenase 1 Homo sapiens 175-179 31134531-0 2019 Nrf2 Mediates the Anti-apoptotic and Anti-inflammatory Effects Induced by Gastrodin in Hydrogen Peroxide-Treated SH-SY5Y Cells. gastrodin 74-83 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 31218587-0 2019 Gastrodin Inhibits Inflammasome Through the STAT3 Signal Pathways in TNA2 Astrocytes and Reactive Astrocytes in Experimentally Induced Cerebral Ischemia in Rats. gastrodin 0-9 signal transducer and activator of transcription 3 Rattus norvegicus 44-49 31128157-0 2019 Protective effect of gastrodin against methamphetamine-induced autophagy in human dopaminergic neuroblastoma SH-SY5Y cells via the AKT/mTOR signaling pathway. gastrodin 21-30 AKT serine/threonine kinase 1 Homo sapiens 131-134 31128157-0 2019 Protective effect of gastrodin against methamphetamine-induced autophagy in human dopaminergic neuroblastoma SH-SY5Y cells via the AKT/mTOR signaling pathway. gastrodin 21-30 mechanistic target of rapamycin kinase Homo sapiens 135-139 31128157-8 2019 Pharmacological intervention was employed to study the role of the AKT/mTOR signaling pathway in the gastrodin-mediated neuroprotection against METH-induced autophagy. gastrodin 101-110 AKT serine/threonine kinase 1 Homo sapiens 67-70 31128157-8 2019 Pharmacological intervention was employed to study the role of the AKT/mTOR signaling pathway in the gastrodin-mediated neuroprotection against METH-induced autophagy. gastrodin 101-110 mechanistic target of rapamycin kinase Homo sapiens 71-75 31128157-10 2019 Gastrodin is observed to block the METH-induced upregulation of LC3B and Beclin-1 protein expression significantly. gastrodin 0-9 microtubule associated protein 1 light chain 3 beta Homo sapiens 64-68 31128157-10 2019 Gastrodin is observed to block the METH-induced upregulation of LC3B and Beclin-1 protein expression significantly. gastrodin 0-9 beclin 1 Homo sapiens 73-81 31128157-11 2019 Gastrodin is found to exhibit an anti-autophagic effect on the inhibition of the METH-induced Beclin-1 protein expression, partly via the AKT/mTOR These findings may aid the development of a gastrodin-based therapeutic strategy for treating METH-induced neurotoxicity. gastrodin 0-9 beclin 1 Homo sapiens 94-102 31128157-11 2019 Gastrodin is found to exhibit an anti-autophagic effect on the inhibition of the METH-induced Beclin-1 protein expression, partly via the AKT/mTOR These findings may aid the development of a gastrodin-based therapeutic strategy for treating METH-induced neurotoxicity. gastrodin 0-9 AKT serine/threonine kinase 1 Homo sapiens 138-141 31128157-11 2019 Gastrodin is found to exhibit an anti-autophagic effect on the inhibition of the METH-induced Beclin-1 protein expression, partly via the AKT/mTOR These findings may aid the development of a gastrodin-based therapeutic strategy for treating METH-induced neurotoxicity. gastrodin 0-9 mechanistic target of rapamycin kinase Homo sapiens 142-146 31128157-11 2019 Gastrodin is found to exhibit an anti-autophagic effect on the inhibition of the METH-induced Beclin-1 protein expression, partly via the AKT/mTOR These findings may aid the development of a gastrodin-based therapeutic strategy for treating METH-induced neurotoxicity. gastrodin 191-200 beclin 1 Homo sapiens 94-102 31128157-11 2019 Gastrodin is found to exhibit an anti-autophagic effect on the inhibition of the METH-induced Beclin-1 protein expression, partly via the AKT/mTOR These findings may aid the development of a gastrodin-based therapeutic strategy for treating METH-induced neurotoxicity. gastrodin 191-200 AKT serine/threonine kinase 1 Homo sapiens 138-141 31128157-11 2019 Gastrodin is found to exhibit an anti-autophagic effect on the inhibition of the METH-induced Beclin-1 protein expression, partly via the AKT/mTOR These findings may aid the development of a gastrodin-based therapeutic strategy for treating METH-induced neurotoxicity. gastrodin 191-200 mechanistic target of rapamycin kinase Homo sapiens 142-146 31026457-10 2019 Moreover, treatment with LiCl, a special Wnt/beta-catenin pathway agonist significantly blocked Gastrodin-mediated down-regulation of iNOS, TNF-alpha, cyclin-D1, NO and the number of cells in the G2/M+S phase of cell cycle in LPS-stimulated BV-2 microglia. gastrodin 96-105 catenin beta 1 Rattus norvegicus 45-57 31026457-10 2019 Moreover, treatment with LiCl, a special Wnt/beta-catenin pathway agonist significantly blocked Gastrodin-mediated down-regulation of iNOS, TNF-alpha, cyclin-D1, NO and the number of cells in the G2/M+S phase of cell cycle in LPS-stimulated BV-2 microglia. gastrodin 96-105 nitric oxide synthase 2 Rattus norvegicus 134-138 31026457-10 2019 Moreover, treatment with LiCl, a special Wnt/beta-catenin pathway agonist significantly blocked Gastrodin-mediated down-regulation of iNOS, TNF-alpha, cyclin-D1, NO and the number of cells in the G2/M+S phase of cell cycle in LPS-stimulated BV-2 microglia. gastrodin 96-105 tumor necrosis factor Rattus norvegicus 140-149 31026457-10 2019 Moreover, treatment with LiCl, a special Wnt/beta-catenin pathway agonist significantly blocked Gastrodin-mediated down-regulation of iNOS, TNF-alpha, cyclin-D1, NO and the number of cells in the G2/M+S phase of cell cycle in LPS-stimulated BV-2 microglia. gastrodin 96-105 cyclin D1 Rattus norvegicus 151-160 31026457-11 2019 Taken together, the present results suggested that Gastrodin mediated anti-inflammatory and anti-proliferation effects in activated microglia by modulating the Wnt/beta-catenin signaling pathway. gastrodin 51-60 Wnt family member 2 Rattus norvegicus 160-163 31026457-11 2019 Taken together, the present results suggested that Gastrodin mediated anti-inflammatory and anti-proliferation effects in activated microglia by modulating the Wnt/beta-catenin signaling pathway. gastrodin 51-60 catenin beta 1 Rattus norvegicus 164-176 30959452-0 2019 Effect of the SSeCKS-TRAF6 interaction on gastrodin-mediated protection against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced astrocyte activation and neuronal death. gastrodin 42-51 A kinase (PRKA) anchor protein (gravin) 12 Mus musculus 14-20 30959452-3 2019 The results show that gastrodin decreased cell viability, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) release, and inducible nitrix oxide synthase (iNOS) and glial fibrillary acidic protein (GFAP) expression in TCDD-treated C6 cells. gastrodin 22-31 glial fibrillary acidic protein Rattus norvegicus 212-216 30959452-0 2019 Effect of the SSeCKS-TRAF6 interaction on gastrodin-mediated protection against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced astrocyte activation and neuronal death. gastrodin 42-51 TNF receptor associated factor 6 Rattus norvegicus 21-26 30959452-6 2019 Gastrodin inhibited TCDD-induced NF-kappaB signalling activation by lessening the SSeCKS-TRAF6 interaction in vitro. gastrodin 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 33-42 30959452-3 2019 The results show that gastrodin decreased cell viability, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) release, and inducible nitrix oxide synthase (iNOS) and glial fibrillary acidic protein (GFAP) expression in TCDD-treated C6 cells. gastrodin 22-31 tumor necrosis factor Rattus norvegicus 58-85 30959452-6 2019 Gastrodin inhibited TCDD-induced NF-kappaB signalling activation by lessening the SSeCKS-TRAF6 interaction in vitro. gastrodin 0-9 A kinase (PRKA) anchor protein (gravin) 12 Mus musculus 82-88 30959452-3 2019 The results show that gastrodin decreased cell viability, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) release, and inducible nitrix oxide synthase (iNOS) and glial fibrillary acidic protein (GFAP) expression in TCDD-treated C6 cells. gastrodin 22-31 tumor necrosis factor Rattus norvegicus 87-96 30959452-6 2019 Gastrodin inhibited TCDD-induced NF-kappaB signalling activation by lessening the SSeCKS-TRAF6 interaction in vitro. gastrodin 0-9 TNF receptor associated factor 6 Rattus norvegicus 89-94 30959452-3 2019 The results show that gastrodin decreased cell viability, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) release, and inducible nitrix oxide synthase (iNOS) and glial fibrillary acidic protein (GFAP) expression in TCDD-treated C6 cells. gastrodin 22-31 interleukin 6 Rattus norvegicus 102-115 30959452-7 2019 Gastrodin attenuated SSeCKS-TRAF6 interaction in vivo and protected mice from NF-kappaB signalling activation following TCDD exposure. gastrodin 0-9 A kinase (PRKA) anchor protein (gravin) 12 Mus musculus 21-27 30959452-3 2019 The results show that gastrodin decreased cell viability, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) release, and inducible nitrix oxide synthase (iNOS) and glial fibrillary acidic protein (GFAP) expression in TCDD-treated C6 cells. gastrodin 22-31 interleukin 6 Rattus norvegicus 117-121 30959452-7 2019 Gastrodin attenuated SSeCKS-TRAF6 interaction in vivo and protected mice from NF-kappaB signalling activation following TCDD exposure. gastrodin 0-9 TNF receptor-associated factor 6 Mus musculus 28-33 30959452-7 2019 Gastrodin attenuated SSeCKS-TRAF6 interaction in vivo and protected mice from NF-kappaB signalling activation following TCDD exposure. gastrodin 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 78-87 30959452-9 2019 In summary, gastrodin inhibited TCDD-induced NF-kappaB signalling activation by lessening the SSeCKS-TRAF6 interaction, resulting in attenuated astrocyte activation and subsequent neuronal apoptosis. gastrodin 12-21 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 45-54 30959452-9 2019 In summary, gastrodin inhibited TCDD-induced NF-kappaB signalling activation by lessening the SSeCKS-TRAF6 interaction, resulting in attenuated astrocyte activation and subsequent neuronal apoptosis. gastrodin 12-21 A kinase (PRKA) anchor protein (gravin) 12 Mus musculus 94-100 30959452-9 2019 In summary, gastrodin inhibited TCDD-induced NF-kappaB signalling activation by lessening the SSeCKS-TRAF6 interaction, resulting in attenuated astrocyte activation and subsequent neuronal apoptosis. gastrodin 12-21 TNF receptor associated factor 6 Rattus norvegicus 101-106 30959452-3 2019 The results show that gastrodin decreased cell viability, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) release, and inducible nitrix oxide synthase (iNOS) and glial fibrillary acidic protein (GFAP) expression in TCDD-treated C6 cells. gastrodin 22-31 glial fibrillary acidic protein Rattus norvegicus 179-210 31105779-0 2019 Protective effect of gastrodin on myocardial ischemia-reperfusion injury and the expression of Bax and Bcl-2. gastrodin 21-30 BCL2, apoptosis regulator Rattus norvegicus 103-108 30716287-0 2019 Post-stroke gastrodin treatment ameliorates ischemic injury and increases neurogenesis and restores the Wnt/beta-Catenin signaling in focal cerebral ischemia in mice. gastrodin 12-21 catenin (cadherin associated protein), beta 1 Mus musculus 108-120 30716287-5 2019 Gastrodin treatment that was started "late" (one day after the ischemic injury) significantly improved neural function, reduced infarct volume and apoptosis, and increased the number of DCX/BrdU double-positive cells in permanent MCAO mice. gastrodin 0-9 doublecortin Mus musculus 186-189 30716287-6 2019 Moreover, gastrodin treatment markedly preserved the Wnt/beta-Catenin signaling pathway, which could promote neurogenesis and provide neuroprotection brain injury. gastrodin 10-19 catenin (cadherin associated protein), beta 1 Mus musculus 57-69 30716287-7 2019 Our findings suggest that gastrodin treatment following ischemic injury can induce neuroprotection, promote neurogenesis and restored the Wnt /beta-Catenin signaling pathway. gastrodin 26-35 catenin (cadherin associated protein), beta 1 Mus musculus 143-155 31105779-10 2019 Gastrodin can downregulate inflammatory cytokines (P<0.05) and upregulate anti-inflammatory cytokines such as IL-10 (P<0.05) in serum of SD rats. gastrodin 0-9 interleukin 10 Rattus norvegicus 113-118 30810603-0 2019 Erratum for: "Gastrodin induced HO-1 and Nrf2 up-regulation to alleviate H2O2-induced oxidative stress in mouse liver sinusoidal endothelial cells through p38 MAPK phosphorylation" [Braz J Med Biol Res (2018) 51(10): e7439]. gastrodin 14-23 nuclear factor, erythroid derived 2, like 2 Mus musculus 41-45 30673960-5 2019 Mechanistically, gastrodin significantly reduced the oxidative stress and inflammatory response, up-regulated the expression of nuclear factor erythroid 2-related factor 2, heme oxygenase-1, phospho-Akt and B-cell lymphoma 2, and down-regulated the expression of BCL2-associated X protein and cleaved caspase-3. gastrodin 17-26 NFE2 like bZIP transcription factor 2 Rattus norvegicus 128-171 30673960-5 2019 Mechanistically, gastrodin significantly reduced the oxidative stress and inflammatory response, up-regulated the expression of nuclear factor erythroid 2-related factor 2, heme oxygenase-1, phospho-Akt and B-cell lymphoma 2, and down-regulated the expression of BCL2-associated X protein and cleaved caspase-3. gastrodin 17-26 heme oxygenase 1 Rattus norvegicus 173-202 30816461-15 2019 From these findings, it was concluded that reduced neurotoxicity in striatal neurons following treatment with gastrodin may be attributed to its suppressive effects on the expression of p-ERK1/2, p-MEK1/2, BDNF and TrKB. gastrodin 110-119 mitogen activated protein kinase 3 Rattus norvegicus 188-194 30816461-15 2019 From these findings, it was concluded that reduced neurotoxicity in striatal neurons following treatment with gastrodin may be attributed to its suppressive effects on the expression of p-ERK1/2, p-MEK1/2, BDNF and TrKB. gastrodin 110-119 brain-derived neurotrophic factor Rattus norvegicus 206-210 30816461-15 2019 From these findings, it was concluded that reduced neurotoxicity in striatal neurons following treatment with gastrodin may be attributed to its suppressive effects on the expression of p-ERK1/2, p-MEK1/2, BDNF and TrKB. gastrodin 110-119 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 215-219 30810603-0 2019 Erratum for: "Gastrodin induced HO-1 and Nrf2 up-regulation to alleviate H2O2-induced oxidative stress in mouse liver sinusoidal endothelial cells through p38 MAPK phosphorylation" [Braz J Med Biol Res (2018) 51(10): e7439]. gastrodin 14-23 mitogen-activated protein kinase 14 Mus musculus 155-158 30075231-2 2018 This study was aimed to determine whether Gastrodin, a common herbal agent known to possess neuroprotective property, can attenuate production of proinflammatory mediators in activated microglia through the renin-angiotensin system (RAS) and Sirtuin3 (SIRT3). gastrodin 42-51 sirtuin 3 Rattus norvegicus 242-250 30242628-5 2019 Gastrodin treatment reduced the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), decreased hepatic malondialdehyde (MDA) content, and increased hepatic superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities in a dose-dependent manner. gastrodin 0-9 glutamic pyruvic transaminase, soluble Mus musculus 52-76 30242628-5 2019 Gastrodin treatment reduced the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), decreased hepatic malondialdehyde (MDA) content, and increased hepatic superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities in a dose-dependent manner. gastrodin 0-9 glutamic pyruvic transaminase, soluble Mus musculus 78-81 30242628-5 2019 Gastrodin treatment reduced the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), decreased hepatic malondialdehyde (MDA) content, and increased hepatic superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities in a dose-dependent manner. gastrodin 0-9 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 87-113 30242628-5 2019 Gastrodin treatment reduced the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), decreased hepatic malondialdehyde (MDA) content, and increased hepatic superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities in a dose-dependent manner. gastrodin 0-9 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 115-118 30242628-5 2019 Gastrodin treatment reduced the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), decreased hepatic malondialdehyde (MDA) content, and increased hepatic superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities in a dose-dependent manner. gastrodin 0-9 catalase Mus musculus 254-262 30242628-5 2019 Gastrodin treatment reduced the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), decreased hepatic malondialdehyde (MDA) content, and increased hepatic superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities in a dose-dependent manner. gastrodin 0-9 catalase Mus musculus 264-267 30524286-0 2018 Gastrodin Ameliorates Cognitive Dysfunction in Diabetes Rat Model via the Suppression of Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation. gastrodin 0-9 NLR family, pyrin domain containing 3 Rattus norvegicus 122-127 30544722-0 2018 Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice. gastrodin 0-9 NLR family, pyrin domain containing 3 Mus musculus 101-106 31949615-11 2018 What"s more, GAS can up-regulate the expression of Bcl-2 and down-regulate the expression of BAX in the ischemic hemisphere, and the same result is observed in the protein level. gastrodin 13-16 BCL2, apoptosis regulator Rattus norvegicus 51-56 31949615-11 2018 What"s more, GAS can up-regulate the expression of Bcl-2 and down-regulate the expression of BAX in the ischemic hemisphere, and the same result is observed in the protein level. gastrodin 13-16 BCL2 associated X, apoptosis regulator Rattus norvegicus 93-96 31949615-12 2018 The expression of Caspase-3 is also suppressed, indicating GAS has ability to inhibit apoptosis during the acute phase of stroke. gastrodin 59-62 caspase 3 Rattus norvegicus 18-27 31949615-13 2018 On the other hand, GAS can up-regulate the expression of VEGF, thusly promoting micro-vacsular regeneration. gastrodin 19-22 vascular endothelial growth factor A Rattus norvegicus 57-61 30075231-2 2018 This study was aimed to determine whether Gastrodin, a common herbal agent known to possess neuroprotective property, can attenuate production of proinflammatory mediators in activated microglia through the renin-angiotensin system (RAS) and Sirtuin3 (SIRT3). gastrodin 42-51 sirtuin 3 Rattus norvegicus 252-257 30156611-0 2018 Gastrodin induced HO-1 and Nrf2 up-regulation to alleviate H2O2-induced oxidative stress in mouse liver sinusoidal endothelial cells through p38 MAPK phosphorylation. gastrodin 0-9 heme oxygenase 1 Mus musculus 18-22 30156611-0 2018 Gastrodin induced HO-1 and Nrf2 up-regulation to alleviate H2O2-induced oxidative stress in mouse liver sinusoidal endothelial cells through p38 MAPK phosphorylation. gastrodin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 27-31 30156611-0 2018 Gastrodin induced HO-1 and Nrf2 up-regulation to alleviate H2O2-induced oxidative stress in mouse liver sinusoidal endothelial cells through p38 MAPK phosphorylation. gastrodin 0-9 mitogen-activated protein kinase 14 Mus musculus 141-144 30147833-0 2018 Gastrodin Protects Cardiomyocytes from Anoxia/Reoxygenation Injury by 14-3-3eta. gastrodin 0-9 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta Homo sapiens 70-79 29393365-0 2018 Gastrodin protects MC3T3-E1 osteoblasts from dexamethasone-induced cellular dysfunction and promotes bone formation via induction of the NRF2 signaling pathway. gastrodin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 137-141 29393365-11 2018 The results revealed that gastrodin prevented the decrease in cell viability caused by DEX-induced MC3T3-E1 cell dysfunction, and that groups pretreated with gastrodin exhibited higher mRNA levels of osteogenic genes, such as Runx2, osterix, bone morphogenetic protein-2 and osteocalcin. gastrodin 158-167 Sp7 transcription factor 7 Mus musculus 233-240 29620267-0 2018 Gastrodin inhibits high glucose-induced human retinal endothelial cell apoptosis by regulating the SIRT1/TLR4/NF-kappaBp65 signaling pathway. gastrodin 0-9 sirtuin 1 Homo sapiens 99-104 29620267-0 2018 Gastrodin inhibits high glucose-induced human retinal endothelial cell apoptosis by regulating the SIRT1/TLR4/NF-kappaBp65 signaling pathway. gastrodin 0-9 toll like receptor 4 Homo sapiens 105-109 29620267-7 2018 However, the administration of gastrodin significantly inhibited the activation of the sirtuin 1 (SIRT1)/TLR4/NF-kappaBp65 signaling pathway in HRECs exposed to HG. gastrodin 31-40 sirtuin 1 Homo sapiens 87-96 29620267-7 2018 However, the administration of gastrodin significantly inhibited the activation of the sirtuin 1 (SIRT1)/TLR4/NF-kappaBp65 signaling pathway in HRECs exposed to HG. gastrodin 31-40 sirtuin 1 Homo sapiens 98-103 29620267-7 2018 However, the administration of gastrodin significantly inhibited the activation of the sirtuin 1 (SIRT1)/TLR4/NF-kappaBp65 signaling pathway in HRECs exposed to HG. gastrodin 31-40 toll like receptor 4 Homo sapiens 105-109 29620267-8 2018 Collectively, the present study demonstrated that gastrodin may be effective against HG-induced apoptosis and its action may be exerted through the regulation of the SIRT1/TLR4/NF-kappaBp65 signaling pathway. gastrodin 50-59 sirtuin 1 Homo sapiens 166-171 29620267-8 2018 Collectively, the present study demonstrated that gastrodin may be effective against HG-induced apoptosis and its action may be exerted through the regulation of the SIRT1/TLR4/NF-kappaBp65 signaling pathway. gastrodin 50-59 toll like receptor 4 Homo sapiens 172-176 29393365-11 2018 The results revealed that gastrodin prevented the decrease in cell viability caused by DEX-induced MC3T3-E1 cell dysfunction, and that groups pretreated with gastrodin exhibited higher mRNA levels of osteogenic genes, such as Runx2, osterix, bone morphogenetic protein-2 and osteocalcin. gastrodin 158-167 runt related transcription factor 2 Mus musculus 226-231 29393365-11 2018 The results revealed that gastrodin prevented the decrease in cell viability caused by DEX-induced MC3T3-E1 cell dysfunction, and that groups pretreated with gastrodin exhibited higher mRNA levels of osteogenic genes, such as Runx2, osterix, bone morphogenetic protein-2 and osteocalcin. gastrodin 158-167 bone morphogenetic protein 2 Mus musculus 242-270 28389632-0 2017 Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway. gastrodin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 71-75 29393365-11 2018 The results revealed that gastrodin prevented the decrease in cell viability caused by DEX-induced MC3T3-E1 cell dysfunction, and that groups pretreated with gastrodin exhibited higher mRNA levels of osteogenic genes, such as Runx2, osterix, bone morphogenetic protein-2 and osteocalcin. gastrodin 158-167 bone gamma-carboxyglutamate protein 2 Mus musculus 275-286 29393365-13 2018 In addition, gastrodin increased osteogenic key marker protein Runx2 while activating NRF2 and downstream effector protein expression. gastrodin 13-22 runt related transcription factor 2 Mus musculus 63-68 29393365-13 2018 In addition, gastrodin increased osteogenic key marker protein Runx2 while activating NRF2 and downstream effector protein expression. gastrodin 13-22 nuclear factor, erythroid derived 2, like 2 Mus musculus 86-90 29115830-0 2018 Gastrodin and Isorhynchophylline Synergistically Inhibit MPP+-Induced Oxidative Stress in SH-SY5Y Cells by Targeting ERK1/2 and GSK-3beta Pathways: Involvement of Nrf2 Nuclear Translocation. gastrodin 0-9 mitogen-activated protein kinase 3 Homo sapiens 117-123 29115830-0 2018 Gastrodin and Isorhynchophylline Synergistically Inhibit MPP+-Induced Oxidative Stress in SH-SY5Y Cells by Targeting ERK1/2 and GSK-3beta Pathways: Involvement of Nrf2 Nuclear Translocation. gastrodin 0-9 glycogen synthase kinase 3 beta Homo sapiens 128-137 29115830-0 2018 Gastrodin and Isorhynchophylline Synergistically Inhibit MPP+-Induced Oxidative Stress in SH-SY5Y Cells by Targeting ERK1/2 and GSK-3beta Pathways: Involvement of Nrf2 Nuclear Translocation. gastrodin 0-9 NFE2 like bZIP transcription factor 2 Homo sapiens 163-167 29545917-0 2018 Gastrodin alleviates glucocorticoid induced osteoporosis in rats via activating the Nrf2 signaling pathways. gastrodin 0-9 NFE2 like bZIP transcription factor 2 Rattus norvegicus 84-88 29545917-7 2018 In addition, gastrodin protected primary osteoblasts from caspase3-related apoptosis by reducing the loss in the mitochondrial membrane potential and decreasing the release of DEX-induced cytochrome-C, bax, and apoptosis inducing factor. gastrodin 13-22 caspase 3 Rattus norvegicus 58-66 29545917-7 2018 In addition, gastrodin protected primary osteoblasts from caspase3-related apoptosis by reducing the loss in the mitochondrial membrane potential and decreasing the release of DEX-induced cytochrome-C, bax, and apoptosis inducing factor. gastrodin 13-22 BCL2 associated X, apoptosis regulator Rattus norvegicus 202-205 29545917-8 2018 Gastrodin also antagonized upregulated endoplasmic reticulum stress signals induced by DEX, including the expression of GRP78, CHOP, and phosphorylated eIF2alpha. gastrodin 0-9 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 120-125 29545917-8 2018 Gastrodin also antagonized upregulated endoplasmic reticulum stress signals induced by DEX, including the expression of GRP78, CHOP, and phosphorylated eIF2alpha. gastrodin 0-9 DNA-damage inducible transcript 3 Rattus norvegicus 127-131 29545917-8 2018 Gastrodin also antagonized upregulated endoplasmic reticulum stress signals induced by DEX, including the expression of GRP78, CHOP, and phosphorylated eIF2alpha. gastrodin 0-9 eukaryotic translation initiation factor 2A Rattus norvegicus 152-161 29545917-9 2018 Furthermore, gastrodin protected osteoblasts by activating the nuclear factor erythroid derived 2-related factor-2 (Nrf2) pathway. gastrodin 13-22 NFE2 like bZIP transcription factor 2 Rattus norvegicus 116-120 29545917-11 2018 Conclusions: These findings suggest that gastrodin alleviated glucocorticoid-induced osteoporosis in rats by protecting osteoblasts via the Nrf2 regulated mitochondrial and ER stress-related signaling pathways. gastrodin 41-50 NFE2 like bZIP transcription factor 2 Rattus norvegicus 140-144 29201182-14 2017 A combination of gastrodin, FOL and V-B12 for EAS can significantly improve inflammatory response symptoms, decrease HCY levels, and increase FOL and V-B12 levels in serum while effectively controlling epileptic seizures, thus exhibiting relatively better clinical efficacy. gastrodin 17-26 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 152-155 28315684-0 2017 BCL6 mediates the effects of Gastrodin on promoting M2-like macrophage polarization and protecting against oxidative stress-induced apoptosis and cell death in macrophages. gastrodin 29-38 BCL6 transcription repressor Homo sapiens 0-4 28315684-4 2017 Gastrodin upregulates the mRNA expression of Mgl2 and Mrc1, M2 macrophage markers, and arginase activity, an M2 polarization indicator, in murine RAW264.7 macrophages. gastrodin 0-9 macrophage galactose N-acetyl-galactosamine specific lectin 2 Mus musculus 45-49 28315684-4 2017 Gastrodin upregulates the mRNA expression of Mgl2 and Mrc1, M2 macrophage markers, and arginase activity, an M2 polarization indicator, in murine RAW264.7 macrophages. gastrodin 0-9 mannose receptor, C type 1 Mus musculus 54-58 28315684-5 2017 Moreover, these effects were blocked by BCL6 siRNA, which also abrogated the protective effects of Gastrodin against hydrogen peroxide-induced apoptosis and death in RAW264.7 cells. gastrodin 99-108 B cell leukemia/lymphoma 6 Mus musculus 40-44 28315684-7 2017 Moreover, we demonstrated that Gastrodin not only stimulated polarization toward M2-like macrophages, which promote tissue repair, but also rescued macrophages from oxidative stress, apoptosis and death by inducing BCL6 expression. gastrodin 31-40 BCL6 transcription repressor Homo sapiens 215-219 28487655-6 2017 Mechanistically, gastrodin attenuated the store-operated Ca2+ entry (SOCE) by reducing the expression of STIM1 and Orai1, two key proteins in SOCE, in animal models as well as in cultured cardiomyocyte model. gastrodin 17-26 stromal interaction molecule 1 Homo sapiens 105-110 28487655-6 2017 Mechanistically, gastrodin attenuated the store-operated Ca2+ entry (SOCE) by reducing the expression of STIM1 and Orai1, two key proteins in SOCE, in animal models as well as in cultured cardiomyocyte model. gastrodin 17-26 ORAI calcium release-activated calcium modulator 1 Homo sapiens 115-120 28487655-8 2017 Together, these results showed that gastrodin inhibited cardiac hypertrophy and it also reduced the SOCE via its action on the expression of STIM1 and Orai1. gastrodin 36-45 stromal interaction molecule 1 Homo sapiens 141-146 28487655-8 2017 Together, these results showed that gastrodin inhibited cardiac hypertrophy and it also reduced the SOCE via its action on the expression of STIM1 and Orai1. gastrodin 36-45 ORAI calcium release-activated calcium modulator 1 Homo sapiens 151-156 28161640-0 2017 Gastrodin inhibits osteoclastogenesis via down-regulating the NFATc1 signaling pathway and stimulates osseointegration in vitro. gastrodin 0-9 nuclear factor of activated T cells 1 Homo sapiens 62-68 28161640-8 2017 Our results showed that gastrodin retarded RANKL-induced osteoclast differentiation efficiently by downregulating transcriptional and translational expression of nuclear factor of activated T cells cl (NFATc1), a major factor in RANKL-mediated osteoclastogenesis. gastrodin 24-33 TNF superfamily member 11 Homo sapiens 43-48 28161640-8 2017 Our results showed that gastrodin retarded RANKL-induced osteoclast differentiation efficiently by downregulating transcriptional and translational expression of nuclear factor of activated T cells cl (NFATc1), a major factor in RANKL-mediated osteoclastogenesis. gastrodin 24-33 nuclear factor of activated T cells 1 Homo sapiens 202-208 28161640-8 2017 Our results showed that gastrodin retarded RANKL-induced osteoclast differentiation efficiently by downregulating transcriptional and translational expression of nuclear factor of activated T cells cl (NFATc1), a major factor in RANKL-mediated osteoclastogenesis. gastrodin 24-33 TNF superfamily member 11 Homo sapiens 229-234 28161640-9 2017 Meanwhile, gastrodin prevented osteoclast maturation and migration by inhibiting the gene expression of dendrocyte expressed seven transmembrane protein (DC-STAMP), an osteoclastic-specific gene that controls cells fusion and movement. gastrodin 11-20 dendrocyte expressed seven transmembrane protein Homo sapiens 104-152 28161640-9 2017 Meanwhile, gastrodin prevented osteoclast maturation and migration by inhibiting the gene expression of dendrocyte expressed seven transmembrane protein (DC-STAMP), an osteoclastic-specific gene that controls cells fusion and movement. gastrodin 11-20 dendrocyte expressed seven transmembrane protein Homo sapiens 154-162 28161640-10 2017 And gastrodin prevented RANKL-induced osteoclastic bone erosion in vitro. gastrodin 4-13 TNF superfamily member 11 Homo sapiens 24-29 28161640-12 2017 In summary, gastrodin could prevent osteoclasts formation and bone resorption via blockage of NFATc1 activity, and stimulate osseointegration in vitro. gastrodin 12-21 nuclear factor of activated T cells 1 Homo sapiens 94-100 29560628-15 2018 The effects of EA+Gastrodin were significantly superior to those of simple EA and simple Gastrodin in shortening the escape latency, up-regulating the expression levels of SIRT 1 and PGC-1 alpha as well as in increasing the percentage of platform quadrant residence time and platform crossing times (P<0.05). gastrodin 18-27 sirtuin 1 Rattus norvegicus 172-178 29560628-15 2018 The effects of EA+Gastrodin were significantly superior to those of simple EA and simple Gastrodin in shortening the escape latency, up-regulating the expression levels of SIRT 1 and PGC-1 alpha as well as in increasing the percentage of platform quadrant residence time and platform crossing times (P<0.05). gastrodin 18-27 PPARG coactivator 1 alpha Rattus norvegicus 183-194 29560628-16 2018 CONCLUSION: Both EA and Gastrodin can improve the learning-memory ability of AD rats, which may be related to their effects in up-regulating the expression of SIRT 1 and PGC-1 alpha and reducing neuronal injury in the CA 1 region of hippocampus, suggesting a protective role of EA on hippocampal neurons. gastrodin 24-33 sirtuin 1 Rattus norvegicus 159-165 29560628-16 2018 CONCLUSION: Both EA and Gastrodin can improve the learning-memory ability of AD rats, which may be related to their effects in up-regulating the expression of SIRT 1 and PGC-1 alpha and reducing neuronal injury in the CA 1 region of hippocampus, suggesting a protective role of EA on hippocampal neurons. gastrodin 24-33 PPARG coactivator 1 alpha Rattus norvegicus 170-181 29115830-3 2018 Thus, the studies reported were designed to test the hypothesis that gastrodin (GAS)-induced de novo synthesis of nuclear factor E2-related factor 2 (Nrf2) and isorhynchophylline (IRN) inhibition of Nrf2 nuclear export contribute to their additive or synergistic neuroprotective effect. gastrodin 69-78 PAXIP1 associated glutamate rich protein 1 Homo sapiens 80-83 29115830-3 2018 Thus, the studies reported were designed to test the hypothesis that gastrodin (GAS)-induced de novo synthesis of nuclear factor E2-related factor 2 (Nrf2) and isorhynchophylline (IRN) inhibition of Nrf2 nuclear export contribute to their additive or synergistic neuroprotective effect. gastrodin 69-78 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 29115830-3 2018 Thus, the studies reported were designed to test the hypothesis that gastrodin (GAS)-induced de novo synthesis of nuclear factor E2-related factor 2 (Nrf2) and isorhynchophylline (IRN) inhibition of Nrf2 nuclear export contribute to their additive or synergistic neuroprotective effect. gastrodin 69-78 NFE2 like bZIP transcription factor 2 Homo sapiens 199-203 29148068-0 2018 Gastrodin protects myocardial cells against hypoxia/reoxygenation injury in neonatal rats by inhibiting cell autophagy through the activation of mTOR signals in PI3K-Akt pathway. gastrodin 0-9 mechanistic target of rapamycin kinase Rattus norvegicus 145-149 29148068-0 2018 Gastrodin protects myocardial cells against hypoxia/reoxygenation injury in neonatal rats by inhibiting cell autophagy through the activation of mTOR signals in PI3K-Akt pathway. gastrodin 0-9 AKT serine/threonine kinase 1 Rattus norvegicus 166-169 29101808-0 2018 Gastrodin reduces IL-1beta-induced apoptosis, inflammation, and matrix catabolism in osteoarthritis chondrocytes and attenuates rat cartilage degeneration in vivo. gastrodin 0-9 interleukin 1 beta Rattus norvegicus 18-26 29101808-5 2018 Our results showed that gastrodin could prevent chondrocyte apoptosis induced by IL-1beta. gastrodin 24-33 interleukin 1 beta Rattus norvegicus 81-89 29101808-6 2018 Additionally, gastrodin suppressed the nuclear factor kappa B (NF-kappaB) pathway, decreased the release of inflammatory mediators (IL-6, TNF-alpha), and reduced matrix catabolism in IL-1beta-treated chondrocytes. gastrodin 14-23 interleukin 6 Rattus norvegicus 132-136 29101808-6 2018 Additionally, gastrodin suppressed the nuclear factor kappa B (NF-kappaB) pathway, decreased the release of inflammatory mediators (IL-6, TNF-alpha), and reduced matrix catabolism in IL-1beta-treated chondrocytes. gastrodin 14-23 tumor necrosis factor Rattus norvegicus 138-147 29101808-6 2018 Additionally, gastrodin suppressed the nuclear factor kappa B (NF-kappaB) pathway, decreased the release of inflammatory mediators (IL-6, TNF-alpha), and reduced matrix catabolism in IL-1beta-treated chondrocytes. gastrodin 14-23 interleukin 1 beta Rattus norvegicus 183-191 29201182-0 2017 The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels. gastrodin 16-25 high mobility group box 1 Homo sapiens 126-132 29201182-0 2017 The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels. gastrodin 16-25 interleukin 2 Homo sapiens 134-138 29201182-0 2017 The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels. gastrodin 16-25 interleukin 6 Homo sapiens 143-147 29201182-1 2017 This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin-B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high-mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels. gastrodin 37-46 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 99-102 29201182-1 2017 This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin-B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high-mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels. gastrodin 37-46 high mobility group box 1 Homo sapiens 167-197 29201182-1 2017 This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin-B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high-mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels. gastrodin 37-46 high mobility group box 1 Homo sapiens 199-205 29201182-1 2017 This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin-B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high-mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels. gastrodin 37-46 interleukin 1 alpha Homo sapiens 208-227 29201182-1 2017 This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin-B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high-mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels. gastrodin 37-46 interleukin 6 Homo sapiens 234-238 28689919-4 2017 In DBTRG-05MG cells but not in CTX TNA2 cells, gastrodin (20-30 muM) induced cytotoxicity, G2/M phase cell cycle arrest and apoptosis. gastrodin 47-56 latexin Homo sapiens 64-67 28689919-5 2017 Regarding oxidative stress, gastrodin (20-30 muM) elevated intracellular ROS levels but reduced GSH levels. gastrodin 28-37 latexin Homo sapiens 45-48 28689919-6 2017 Treatment with the antioxidant NAC (10 muM) partially reversed gastrodin-altered antioxidant enzymes levels. gastrodin 63-72 synuclein alpha Homo sapiens 31-34 28689919-6 2017 Treatment with the antioxidant NAC (10 muM) partially reversed gastrodin-altered antioxidant enzymes levels. gastrodin 63-72 latexin Homo sapiens 39-42 28689919-8 2017 The apoptotic effects evoked by gastrodin were partially inhibited by the antioxidant NAC and the pancaspase inhibitor Z-VAD-FMK. gastrodin 32-41 synuclein alpha Homo sapiens 86-89 29207618-0 2017 Neuroprotective effect of a novel gastrodin derivative against ischemic brain injury: involvement of peroxiredoxin and TLR4 signaling inhibition. gastrodin 34-43 toll-like receptor 4 Rattus norvegicus 119-123 27909971-4 2017 Further studies demonstrated that gastrodin decreased the levels of the pro-inflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha while increasing interleukin-10, an anti-inflammatory cytokine in the brain. gastrodin 34-43 interleukin 1 beta Mus musculus 99-148 27909971-4 2017 Further studies demonstrated that gastrodin decreased the levels of the pro-inflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha while increasing interleukin-10, an anti-inflammatory cytokine in the brain. gastrodin 34-43 interleukin 10 Mus musculus 166-180 27909971-5 2017 Furthermore, gastrodin attenuated the PTZ-induced microglial activation along with inhibition of mitogen-activated protein kinases, cAMP response element binding protein, and NF-kappaB. gastrodin 13-22 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 175-184 27743286-0 2017 Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents. gastrodin 0-9 neuron navigator 1 Rattus norvegicus 122-126 27821233-5 2016 Results: Gastrodin, astragaloside and paeoniflorin enhanced the learning and memory ability of 5XFAD mice, and reduced Abeta in the cerebral homogenate and Abeta plaques in brain. gastrodin 9-18 amyloid beta (A4) precursor protein Mus musculus 119-124 27710899-0 2016 Proliferation-enhancing effects of gastrodin on RSC96 Schwann cells by regulating ERK1/2 and PI3K signaling pathways. gastrodin 35-44 mitogen activated protein kinase 3 Rattus norvegicus 82-88 27821233-5 2016 Results: Gastrodin, astragaloside and paeoniflorin enhanced the learning and memory ability of 5XFAD mice, and reduced Abeta in the cerebral homogenate and Abeta plaques in brain. gastrodin 9-18 amyloid beta (A4) precursor protein Mus musculus 156-161 27109341-11 2016 WGE and gastrodin inhibited the activity and protein expression of MAO-A, and increased TH levels in PC12 cells. gastrodin 8-17 monoamine oxidase A Rattus norvegicus 67-72 27641420-0 2016 Gastrodin Pretreatment Impact on Sarcoplasmic Reticulum Calcium Transport ATPase (SERCA) and Calcium Phosphate (PLB) Expression in Rats with Myocardial Ischemia Reperfusion. gastrodin 0-9 phospholamban Rattus norvegicus 112-115 27641420-15 2016 CONCLUSIONS Gastrodin pretreatment alleviates MIRI and inflammation injury by regulating SERCA and PLB expression to decrease calcium overload. gastrodin 12-21 phospholamban Rattus norvegicus 99-102 27109341-11 2016 WGE and gastrodin inhibited the activity and protein expression of MAO-A, and increased TH levels in PC12 cells. gastrodin 8-17 tyrosine hydroxylase Rattus norvegicus 88-90 27188468-9 2016 The effect of gastrodin on synaptic transmission was evaluated on hippocampal CA1 Schaffer collaterals. gastrodin 14-23 carbonic anhydrase 1 Rattus norvegicus 78-81 27188468-10 2016 Application of 25 muM gastrodin significantly suppressed NMDA excitotoxicity in CA3 but not in CA1 hippocampus and dentate gyrus. gastrodin 22-31 carbonic anhydrase 3 Rattus norvegicus 80-83 26498411-9 2015 The serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) decreased with gastrodin treatment by 15.1 and 23.6 percent respectively in comparison to BDL group did not receive gastrodin. gastrodin 99-108 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 51-77 26634892-0 2016 Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway. gastrodin 0-9 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 116-120 26634892-0 2016 Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway. gastrodin 0-9 NFE2 like bZIP transcription factor 2 Rattus norvegicus 121-125 27141624-1 2016 OBJECTIVE: To observe the effect of electroacupuncture (EA) intervention combined with medication (Gastrodin) on changes of neurological function and expression of Nogo-A and Nogo-A receptor (NgR) in the frontal lobe cortex around the ischemic loci of focal cerebral ischemia (FCI) rats, so as to explore its mechanism underlying improvement of neuroregeneration of FC. gastrodin 99-108 reticulon 4 Rattus norvegicus 164-170 27141624-1 2016 OBJECTIVE: To observe the effect of electroacupuncture (EA) intervention combined with medication (Gastrodin) on changes of neurological function and expression of Nogo-A and Nogo-A receptor (NgR) in the frontal lobe cortex around the ischemic loci of focal cerebral ischemia (FCI) rats, so as to explore its mechanism underlying improvement of neuroregeneration of FC. gastrodin 99-108 reticulon 4 receptor Rattus norvegicus 175-190 27141624-1 2016 OBJECTIVE: To observe the effect of electroacupuncture (EA) intervention combined with medication (Gastrodin) on changes of neurological function and expression of Nogo-A and Nogo-A receptor (NgR) in the frontal lobe cortex around the ischemic loci of focal cerebral ischemia (FCI) rats, so as to explore its mechanism underlying improvement of neuroregeneration of FC. gastrodin 99-108 reticulon 4 receptor Rattus norvegicus 192-195 27141624-11 2016 CONCLUSION: EA intervention and Gastrodin administration can down-regulate cerebro-cortical Nogo-A and NgR protein expression in FCI rats, which may contribute to their action in improving neurological impairment. gastrodin 32-41 reticulon 4 Rattus norvegicus 92-98 27141624-11 2016 CONCLUSION: EA intervention and Gastrodin administration can down-regulate cerebro-cortical Nogo-A and NgR protein expression in FCI rats, which may contribute to their action in improving neurological impairment. gastrodin 32-41 reticulon 4 receptor Rattus norvegicus 103-106 26498411-9 2015 The serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) decreased with gastrodin treatment by 15.1 and 23.6 percent respectively in comparison to BDL group did not receive gastrodin. gastrodin 99-108 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 79-82 26887206-0 2015 [Effects of Electroacupuncture Intervention Combined with Gastrodin on Expression of Proteins Related to Proliferation-differentiation of Neural Stem Cells in Hippocampal CA 1 and CA 3 Regions in Focal Cerebral Ischemia Rats]. gastrodin 58-67 carbonic anhydrase 1 Rattus norvegicus 171-175 26887206-10 2015 CONCLUSION: EA and EA intervention combined with gastrodin can significantly up-regulate the number of Nestin- and NSE-IR positive cells, and down-regulate the number of GFAP positive cells in the CA 1 and CA 3 regions of hippocampus in focal cerebral ischemia rats, which may contribute to their effects in promoting the differentiation and proliferation of mature neurons in the hippocampus for improving cerebral functions. gastrodin 49-58 nestin Rattus norvegicus 103-109 26887206-10 2015 CONCLUSION: EA and EA intervention combined with gastrodin can significantly up-regulate the number of Nestin- and NSE-IR positive cells, and down-regulate the number of GFAP positive cells in the CA 1 and CA 3 regions of hippocampus in focal cerebral ischemia rats, which may contribute to their effects in promoting the differentiation and proliferation of mature neurons in the hippocampus for improving cerebral functions. gastrodin 49-58 enolase 2 Rattus norvegicus 115-118 26887206-10 2015 CONCLUSION: EA and EA intervention combined with gastrodin can significantly up-regulate the number of Nestin- and NSE-IR positive cells, and down-regulate the number of GFAP positive cells in the CA 1 and CA 3 regions of hippocampus in focal cerebral ischemia rats, which may contribute to their effects in promoting the differentiation and proliferation of mature neurons in the hippocampus for improving cerebral functions. gastrodin 49-58 glial fibrillary acidic protein Rattus norvegicus 170-174 26887206-10 2015 CONCLUSION: EA and EA intervention combined with gastrodin can significantly up-regulate the number of Nestin- and NSE-IR positive cells, and down-regulate the number of GFAP positive cells in the CA 1 and CA 3 regions of hippocampus in focal cerebral ischemia rats, which may contribute to their effects in promoting the differentiation and proliferation of mature neurons in the hippocampus for improving cerebral functions. gastrodin 49-58 carbonic anhydrase 1 Rattus norvegicus 197-201 26887206-10 2015 CONCLUSION: EA and EA intervention combined with gastrodin can significantly up-regulate the number of Nestin- and NSE-IR positive cells, and down-regulate the number of GFAP positive cells in the CA 1 and CA 3 regions of hippocampus in focal cerebral ischemia rats, which may contribute to their effects in promoting the differentiation and proliferation of mature neurons in the hippocampus for improving cerebral functions. gastrodin 49-58 carbonic anhydrase 3 Rattus norvegicus 206-210 25554600-8 2015 Moreover, gastrodin reduced the number of osteoclasts, TRAP activity and the expression of osteoclast-specific genes in RAW264.7 cells. gastrodin 10-19 tudor domain containing 7 Mus musculus 55-59 25817367-6 2015 Gastrodin treatment prevented the increase of serotonin transporter (SERT) and the decrease of serotonin 1A (5-HT1A) receptor expression in the hippocampus of IDPN-treated rats. gastrodin 0-9 solute carrier family 6 member 4 Rattus norvegicus 69-73 25554600-11 2015 Our data revealed that gastrodin treatment reduced the activity of serum bone degradation markers, such as CTX-1 and TRAP. gastrodin 23-32 tudor domain containing 7 Mus musculus 117-121 25554600-13 2015 Gastrodin decreased osteoclast numbers in vivo by TRAP staining. gastrodin 0-9 tudor domain containing 7 Mus musculus 50-54 26587048-0 2015 Gastrodin Reduces Blood Pressure by Intervening with RAAS and PPARgamma in SHRs. gastrodin 0-9 peroxisome proliferator activated receptor gamma Homo sapiens 62-71 25817367-6 2015 Gastrodin treatment prevented the increase of serotonin transporter (SERT) and the decrease of serotonin 1A (5-HT1A) receptor expression in the hippocampus of IDPN-treated rats. gastrodin 0-9 solute carrier family 6 member 4 Rattus norvegicus 46-67 26587048-6 2015 Additionally, gastrodin increased the mRNA expression (0.18 +- 0.07 versus 0.82 +- 0.10, P < 0.01) and protein synthesis (0.40 +- 0.10 versus 0.34 +- 0.10, P < 0.01) of peroxisome proliferator-activated receptor gamma (PPARgamma) in myocardium tissues. gastrodin 14-23 peroxisome proliferator activated receptor gamma Homo sapiens 175-223 26587048-6 2015 Additionally, gastrodin increased the mRNA expression (0.18 +- 0.07 versus 0.82 +- 0.10, P < 0.01) and protein synthesis (0.40 +- 0.10 versus 0.34 +- 0.10, P < 0.01) of peroxisome proliferator-activated receptor gamma (PPARgamma) in myocardium tissues. gastrodin 14-23 peroxisome proliferator activated receptor gamma Homo sapiens 225-234 25132361-10 2014 Interestingly, MPTP-intoxicated mice treated with gastrodin robustly increased heme oxygenase 1, superoxide dismutase, glutathione levels, and Nrf2 nuclear translocation in striatum of MPTP-intoxicated mice. gastrodin 50-59 heme oxygenase 1 Mus musculus 79-95 25132361-0 2014 Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson"s disease: involvement of ERK1/2-Nrf2 signaling pathway. gastrodin 0-9 mitogen-activated protein kinase 3 Mus musculus 118-124 25132361-0 2014 Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson"s disease: involvement of ERK1/2-Nrf2 signaling pathway. gastrodin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 125-129 25132361-10 2014 Interestingly, MPTP-intoxicated mice treated with gastrodin robustly increased heme oxygenase 1, superoxide dismutase, glutathione levels, and Nrf2 nuclear translocation in striatum of MPTP-intoxicated mice. gastrodin 50-59 nuclear factor, erythroid derived 2, like 2 Mus musculus 143-147 25132361-3 2014 The present study evaluates the hypothesis that prevention of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor deficits by gastrodin might mainly result from its antioxidant property via interrupting extracellular signal regulated protein kinases (ERK) 1/2-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. gastrodin 140-149 nuclear factor, erythroid derived 2, like 2 Mus musculus 319-323 25132361-12 2014 SIGNIFICANCE: Gastrodin protects midbrain of MPTP-intoxicated mice against oxidative stress, in part, through interrupting ERK1/2-Nrf2 pathway mechanism, which will give us an insight into the potential of gastrodin in terms of opening up new therapeutic avenues for PD. gastrodin 14-23 mitogen-activated protein kinase 3 Mus musculus 123-129 25132361-12 2014 SIGNIFICANCE: Gastrodin protects midbrain of MPTP-intoxicated mice against oxidative stress, in part, through interrupting ERK1/2-Nrf2 pathway mechanism, which will give us an insight into the potential of gastrodin in terms of opening up new therapeutic avenues for PD. gastrodin 14-23 nuclear factor, erythroid derived 2, like 2 Mus musculus 130-134 25132361-12 2014 SIGNIFICANCE: Gastrodin protects midbrain of MPTP-intoxicated mice against oxidative stress, in part, through interrupting ERK1/2-Nrf2 pathway mechanism, which will give us an insight into the potential of gastrodin in terms of opening up new therapeutic avenues for PD. gastrodin 206-215 mitogen-activated protein kinase 3 Mus musculus 123-129 25132361-12 2014 SIGNIFICANCE: Gastrodin protects midbrain of MPTP-intoxicated mice against oxidative stress, in part, through interrupting ERK1/2-Nrf2 pathway mechanism, which will give us an insight into the potential of gastrodin in terms of opening up new therapeutic avenues for PD. gastrodin 206-215 nuclear factor, erythroid derived 2, like 2 Mus musculus 130-134 24619207-6 2014 Additionally, gastrodin blocked the expression of p53 phosphorylation, caspase-3 and cytochrome C, reduced bax/bcl-2 ratio induced by glutamate in PC12 cells. gastrodin 14-23 BCL2, apoptosis regulator Rattus norvegicus 111-116 24932697-0 2014 Gastrodin protects against MPP(+)-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK/Nrf2 pathway in human dopaminergic cells. gastrodin 0-9 heme oxygenase 1 Homo sapiens 75-91 24932697-0 2014 Gastrodin protects against MPP(+)-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK/Nrf2 pathway in human dopaminergic cells. gastrodin 0-9 NFE2 like bZIP transcription factor 2 Homo sapiens 120-124 24932697-5 2014 In addition, gastrodin inhibited MPP(+)-induced lowered membrane potential, decreased Bcl-2/Bax ratio. gastrodin 13-22 BCL2 apoptosis regulator Homo sapiens 86-91 24932697-5 2014 In addition, gastrodin inhibited MPP(+)-induced lowered membrane potential, decreased Bcl-2/Bax ratio. gastrodin 13-22 BCL2 associated X, apoptosis regulator Homo sapiens 92-95 24932697-8 2014 And the increase in HO-1 expression was correlated with the protective effect of gastrodin against MPP(+)-induced injury. gastrodin 81-90 heme oxygenase 1 Homo sapiens 20-24 24932697-9 2014 Because the inhibitor of HO-1 activity, ZnPP reversed the protective effect of gastrodin against MPP(+)-induced cell death. gastrodin 79-88 heme oxygenase 1 Homo sapiens 25-29 24932697-11 2014 Taken together, these findings suggest that gastrodin can induce HO-1 expression through activation of p38 MAPK/Nrf2 signaling pathway, thereby protecting the SH-SY5Y cells from MPP(+)-induced oxidative cell death. gastrodin 44-53 heme oxygenase 1 Homo sapiens 65-69 24932697-11 2014 Taken together, these findings suggest that gastrodin can induce HO-1 expression through activation of p38 MAPK/Nrf2 signaling pathway, thereby protecting the SH-SY5Y cells from MPP(+)-induced oxidative cell death. gastrodin 44-53 NFE2 like bZIP transcription factor 2 Homo sapiens 112-116 25212023-7 2014 The results showed that 4 of the 10 compounds could reduce the level of extracellular Abeta; they were cryptotanshinone, astragalosides, gastrodin and paeoniflorin, and their best concentration ranges were 0.5-5.0, 0.5-5.0, 5.0-50, 1.0-25 micromol x L(-1), respectively. gastrodin 137-146 amyloid beta precursor protein Homo sapiens 86-91 25212023-8 2014 Further study indicated that the 4 selected compounds were nontoxic to the cellular models and lowering intracellular Abeta were more effective compared with extracellular; of which astragalosides and gastrodin showed dose-dependent inhibition to the activities of beta and gamma-secretases, with the maximum inhibiting rates of 78.2% and 80.3%, respectively. gastrodin 201-210 amyloid beta precursor protein Homo sapiens 118-123 25212023-9 2014 In conclusion, cryptotanshinone, astragalosides, gastrodin and paeoniflorin could inhibit the expression and secretion of Abeta, and the underlying inhibiting mechanism of astragalosides and gastrodin were related with the reduction of the beta and gamma-secretase activities, respectively. gastrodin 49-58 amyloid beta precursor protein Homo sapiens 122-127 25212023-9 2014 In conclusion, cryptotanshinone, astragalosides, gastrodin and paeoniflorin could inhibit the expression and secretion of Abeta, and the underlying inhibiting mechanism of astragalosides and gastrodin were related with the reduction of the beta and gamma-secretase activities, respectively. gastrodin 191-200 amyloid beta precursor protein Homo sapiens 122-127 24619207-7 2014 All these findings indicate that gastrodin protects PC12 cells from the apoptosis induced by glutamate through a new mechanism of the CaMKII/ASK-1/p38 MAPK/p53-signaling pathway. gastrodin 33-42 mitogen-activated protein kinase kinase kinase 5 Rattus norvegicus 141-146 24619207-7 2014 All these findings indicate that gastrodin protects PC12 cells from the apoptosis induced by glutamate through a new mechanism of the CaMKII/ASK-1/p38 MAPK/p53-signaling pathway. gastrodin 33-42 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 156-159 23376120-4 2013 Our results showed that gastrodin treatment strongly suppressed nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPKs) family activation and upregulation of the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in LPS-stimulated H9c2 cardiomyocytes. gastrodin 24-33 nitric oxide synthase 2 Rattus norvegicus 200-231 24293261-0 2014 Gastrodin ameliorates depressive-like behaviors and up-regulates the expression of BDNF in the hippocampus and hippocampal-derived astrocyte of rats. gastrodin 0-9 brain-derived neurotrophic factor Rattus norvegicus 83-87 24293261-9 2014 Increased levels of ERK1/2 phosphorylation and BDNF protein were also observed after GAS (20 mug/mL) treatment for 72 h. These results indicate that gastrodin possesses antidepressant effect. gastrodin 149-158 mitogen activated protein kinase 3 Rattus norvegicus 20-26 24293261-9 2014 Increased levels of ERK1/2 phosphorylation and BDNF protein were also observed after GAS (20 mug/mL) treatment for 72 h. These results indicate that gastrodin possesses antidepressant effect. gastrodin 149-158 brain-derived neurotrophic factor Rattus norvegicus 47-51 23480725-7 2013 Glucose or phlorizin, a sodium-dependent GLT (SGLT) inhibitor, reduced the absorption rates of gastrodin from perfused rat intestines. gastrodin 95-104 solute carrier family 1 member 2 Rattus norvegicus 41-44 23480725-9 2013 However, the Tmax of gastrodin in diabetic rats was significantly lowered to 20 min because of the high intestinal SGLT1 level. gastrodin 21-30 solute carrier family 5 member 1 Rattus norvegicus 115-120 23578476-0 2013 Gastrodin stimulates anticancer immune response and represses transplanted H22 hepatic ascitic tumor cell growth: Involvement of NF-kappaB signaling activation in CD4+ T cells. gastrodin 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 129-138 23578476-9 2013 Gastrodin administration specifically upregulated mRNA levels of several nuclear factor kappaB (NF-kappaB) responsive genes in CD4+ T cells but not in CD8+ T cells. gastrodin 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 88-94 23578476-9 2013 Gastrodin administration specifically upregulated mRNA levels of several nuclear factor kappaB (NF-kappaB) responsive genes in CD4+ T cells but not in CD8+ T cells. gastrodin 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 96-105 23578476-10 2013 Chromatin immunoprecipitation assay showed that gastrodin increased the association of NF-kappaB p65 subunit to the promoter regions of IL-2 and Bcl-2 encoding genes in CD4+ T cells. gastrodin 48-57 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 90-96 23578476-10 2013 Chromatin immunoprecipitation assay showed that gastrodin increased the association of NF-kappaB p65 subunit to the promoter regions of IL-2 and Bcl-2 encoding genes in CD4+ T cells. gastrodin 48-57 interleukin 2 Mus musculus 136-140 23578476-10 2013 Chromatin immunoprecipitation assay showed that gastrodin increased the association of NF-kappaB p65 subunit to the promoter regions of IL-2 and Bcl-2 encoding genes in CD4+ T cells. gastrodin 48-57 B cell leukemia/lymphoma 2 Mus musculus 145-150 25206433-0 2013 Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord. gastrodin 0-9 brain-derived neurotrophic factor Rattus norvegicus 36-69 25206433-3 2013 Results show that gastrodin promoted the secretion of brain-derived neurotrophic factor in rats with spinal cord injury. gastrodin 18-27 brain-derived neurotrophic factor Rattus norvegicus 54-87 25206433-6 2013 These results demonstrate that gastrodin promotes the secretion of brain-derived neurotrophic factor, contributes to the recovery of neurological function, and protects neural cells against injury. gastrodin 31-40 brain-derived neurotrophic factor Rattus norvegicus 67-100 24619207-0 2014 Gastrodin inhibits glutamate-induced apoptosis of PC12 cells via inhibition of CaMKII/ASK-1/p38 MAPK/p53 signaling cascade. gastrodin 0-9 mitogen-activated protein kinase kinase kinase 5 Rattus norvegicus 86-91 24619207-0 2014 Gastrodin inhibits glutamate-induced apoptosis of PC12 cells via inhibition of CaMKII/ASK-1/p38 MAPK/p53 signaling cascade. gastrodin 0-9 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 101-104 24619207-6 2014 Additionally, gastrodin blocked the expression of p53 phosphorylation, caspase-3 and cytochrome C, reduced bax/bcl-2 ratio induced by glutamate in PC12 cells. gastrodin 14-23 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 50-53 24619207-6 2014 Additionally, gastrodin blocked the expression of p53 phosphorylation, caspase-3 and cytochrome C, reduced bax/bcl-2 ratio induced by glutamate in PC12 cells. gastrodin 14-23 caspase 3 Rattus norvegicus 71-80 24619207-6 2014 Additionally, gastrodin blocked the expression of p53 phosphorylation, caspase-3 and cytochrome C, reduced bax/bcl-2 ratio induced by glutamate in PC12 cells. gastrodin 14-23 BCL2 associated X, apoptosis regulator Rattus norvegicus 107-110 25421192-12 2014 Compared with the control group and the gastrodin+steroid group, the mRNA and protein expression levels of Bax and Caspase-3 were significantly higher in the steroid group, but the Bcl-2 mRNA and protein expression levels were significantly lower. gastrodin 40-49 BCL2 associated X, apoptosis regulator Rattus norvegicus 107-110 25421192-12 2014 Compared with the control group and the gastrodin+steroid group, the mRNA and protein expression levels of Bax and Caspase-3 were significantly higher in the steroid group, but the Bcl-2 mRNA and protein expression levels were significantly lower. gastrodin 40-49 caspase 3 Rattus norvegicus 115-124 25421192-12 2014 Compared with the control group and the gastrodin+steroid group, the mRNA and protein expression levels of Bax and Caspase-3 were significantly higher in the steroid group, but the Bcl-2 mRNA and protein expression levels were significantly lower. gastrodin 40-49 BCL2, apoptosis regulator Rattus norvegicus 181-186 23783886-0 2013 Gastrodin ameliorates Parkinson"s disease by downregulating connexin 43. gastrodin 0-9 gap junction protein alpha 1 Homo sapiens 60-71 23376120-4 2013 Our results showed that gastrodin treatment strongly suppressed nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPKs) family activation and upregulation of the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in LPS-stimulated H9c2 cardiomyocytes. gastrodin 24-33 nitric oxide synthase 2 Rattus norvegicus 233-237 23376120-4 2013 Our results showed that gastrodin treatment strongly suppressed nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPKs) family activation and upregulation of the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in LPS-stimulated H9c2 cardiomyocytes. gastrodin 24-33 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 240-256 23376120-4 2013 Our results showed that gastrodin treatment strongly suppressed nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPKs) family activation and upregulation of the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in LPS-stimulated H9c2 cardiomyocytes. gastrodin 24-33 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 258-263 23376120-4 2013 Our results showed that gastrodin treatment strongly suppressed nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPKs) family activation and upregulation of the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in LPS-stimulated H9c2 cardiomyocytes. gastrodin 24-33 tumor necrosis factor Rattus norvegicus 266-293 23376120-4 2013 Our results showed that gastrodin treatment strongly suppressed nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPKs) family activation and upregulation of the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in LPS-stimulated H9c2 cardiomyocytes. gastrodin 24-33 tumor necrosis factor Rattus norvegicus 295-304 23376120-4 2013 Our results showed that gastrodin treatment strongly suppressed nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPKs) family activation and upregulation of the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in LPS-stimulated H9c2 cardiomyocytes. gastrodin 24-33 interleukin 6 Rattus norvegicus 311-324 23376120-4 2013 Our results showed that gastrodin treatment strongly suppressed nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPKs) family activation and upregulation of the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in LPS-stimulated H9c2 cardiomyocytes. gastrodin 24-33 interleukin 6 Rattus norvegicus 326-330 23376120-5 2013 Simultaneously, gastrodin obviously upregulated the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling in a dose-dependent manner. gastrodin 16-25 AKT serine/threonine kinase 1 Rattus norvegicus 90-93 23533492-4 2013 Gastrodin significantly and dose dependently protected dopaminergic neurons against neurotoxicity through regulating free radicals, Bax/Bcl-2 mRNA, caspase-3, and cleaved poly(ADP-ribose) polymerase (PARP) in SH-SY5Y cells stressed with MPP(+). gastrodin 0-9 BCL2 associated X, apoptosis regulator Homo sapiens 132-135 23533492-4 2013 Gastrodin significantly and dose dependently protected dopaminergic neurons against neurotoxicity through regulating free radicals, Bax/Bcl-2 mRNA, caspase-3, and cleaved poly(ADP-ribose) polymerase (PARP) in SH-SY5Y cells stressed with MPP(+). gastrodin 0-9 BCL2 apoptosis regulator Homo sapiens 136-141 23533492-4 2013 Gastrodin significantly and dose dependently protected dopaminergic neurons against neurotoxicity through regulating free radicals, Bax/Bcl-2 mRNA, caspase-3, and cleaved poly(ADP-ribose) polymerase (PARP) in SH-SY5Y cells stressed with MPP(+). gastrodin 0-9 caspase 3 Homo sapiens 148-157 23533492-4 2013 Gastrodin significantly and dose dependently protected dopaminergic neurons against neurotoxicity through regulating free radicals, Bax/Bcl-2 mRNA, caspase-3, and cleaved poly(ADP-ribose) polymerase (PARP) in SH-SY5Y cells stressed with MPP(+). gastrodin 0-9 poly(ADP-ribose) polymerase 1 Homo sapiens 171-198 23533492-4 2013 Gastrodin significantly and dose dependently protected dopaminergic neurons against neurotoxicity through regulating free radicals, Bax/Bcl-2 mRNA, caspase-3, and cleaved poly(ADP-ribose) polymerase (PARP) in SH-SY5Y cells stressed with MPP(+). gastrodin 0-9 poly(ADP-ribose) polymerase 1 Homo sapiens 200-204 24020812-0 2013 Gastrodin ameliorates anxiety-like behaviors and inhibits IL-1beta level and p38 MAPK phosphorylation of hippocampus in the rat model of posttraumatic stress disorder. gastrodin 0-9 interleukin 1 beta Rattus norvegicus 58-66 24020812-0 2013 Gastrodin ameliorates anxiety-like behaviors and inhibits IL-1beta level and p38 MAPK phosphorylation of hippocampus in the rat model of posttraumatic stress disorder. gastrodin 0-9 mitogen activated protein kinase 14 Rattus norvegicus 77-80 24020812-6 2013 However, repeated treatment with gastrodin, particularly at higher doses, reversed the aforementioned changes, including anxiety-like behavior, levels of IL-6 and IL-1beta, and the expression of iNOS and the p38 MAPK phosphorylation. gastrodin 33-42 interleukin 6 Rattus norvegicus 154-158 24020812-6 2013 However, repeated treatment with gastrodin, particularly at higher doses, reversed the aforementioned changes, including anxiety-like behavior, levels of IL-6 and IL-1beta, and the expression of iNOS and the p38 MAPK phosphorylation. gastrodin 33-42 interleukin 1 beta Rattus norvegicus 163-171 24020812-6 2013 However, repeated treatment with gastrodin, particularly at higher doses, reversed the aforementioned changes, including anxiety-like behavior, levels of IL-6 and IL-1beta, and the expression of iNOS and the p38 MAPK phosphorylation. gastrodin 33-42 nitric oxide synthase 2 Rattus norvegicus 195-199 24020812-6 2013 However, repeated treatment with gastrodin, particularly at higher doses, reversed the aforementioned changes, including anxiety-like behavior, levels of IL-6 and IL-1beta, and the expression of iNOS and the p38 MAPK phosphorylation. gastrodin 33-42 mitogen activated protein kinase 14 Rattus norvegicus 208-211 25774170-7 2012 Treatment of rats with gastrodin or Madopar at 28 days significantly reduced interleukin-1beta expression. gastrodin 23-32 interleukin 1 beta Rattus norvegicus 77-94 22922870-8 2012 Gastrodin influenced the S-phase entry of VSMCs and stabilised p27Kip1 expression. gastrodin 0-9 cyclin-dependent kinase inhibitor 1B Mus musculus 63-70 22922870-13 2012 Furthermore, the ERK1/2, p38 MAPK and Akt/GSK3beta signalling pathways were found to be involved in the effects of gastrodin. gastrodin 115-124 mitogen-activated protein kinase 3 Mus musculus 17-23 22922870-13 2012 Furthermore, the ERK1/2, p38 MAPK and Akt/GSK3beta signalling pathways were found to be involved in the effects of gastrodin. gastrodin 115-124 mitogen-activated protein kinase 14 Mus musculus 25-33 22922870-13 2012 Furthermore, the ERK1/2, p38 MAPK and Akt/GSK3beta signalling pathways were found to be involved in the effects of gastrodin. gastrodin 115-124 thymoma viral proto-oncogene 1 Mus musculus 38-41 22922870-13 2012 Furthermore, the ERK1/2, p38 MAPK and Akt/GSK3beta signalling pathways were found to be involved in the effects of gastrodin. gastrodin 115-124 glycogen synthase kinase 3 beta Mus musculus 42-50 22982592-0 2012 Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway. gastrodin 0-9 mitogen activated protein kinase 3 Rattus norvegicus 114-120 22982592-0 2012 Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway. gastrodin 0-9 NFE2 like bZIP transcription factor 2 Rattus norvegicus 121-125 22982592-4 2012 Pre-treatment of primary hippocampal neurons with gastrodin significantly attenuated Abeta(1-42)-induced neurotoxicity and changes in SOD and CAT, and upregulated gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation. gastrodin 50-59 catalase Rattus norvegicus 142-145 22982592-4 2012 Pre-treatment of primary hippocampal neurons with gastrodin significantly attenuated Abeta(1-42)-induced neurotoxicity and changes in SOD and CAT, and upregulated gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation. gastrodin 50-59 NFE2 like bZIP transcription factor 2 Rattus norvegicus 182-225 22982592-4 2012 Pre-treatment of primary hippocampal neurons with gastrodin significantly attenuated Abeta(1-42)-induced neurotoxicity and changes in SOD and CAT, and upregulated gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation. gastrodin 50-59 NFE2 like bZIP transcription factor 2 Rattus norvegicus 227-231 22982592-4 2012 Pre-treatment of primary hippocampal neurons with gastrodin significantly attenuated Abeta(1-42)-induced neurotoxicity and changes in SOD and CAT, and upregulated gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation. gastrodin 50-59 mitogen activated protein kinase 3 Rattus norvegicus 237-283 22982592-4 2012 Pre-treatment of primary hippocampal neurons with gastrodin significantly attenuated Abeta(1-42)-induced neurotoxicity and changes in SOD and CAT, and upregulated gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation. gastrodin 50-59 mitogen activated protein kinase 3 Rattus norvegicus 285-291 22982592-5 2012 Pharmacological blockade of ERK1/2 abrogation this action of gastrodin. gastrodin 61-70 mitogen activated protein kinase 3 Rattus norvegicus 28-34 22982592-6 2012 The ERK1/2 pathway may be involved in the neuroprotective effect of gastrodin against Abeta(1-42)-induced oxidative in primary cultured rat hippocampal neurons. gastrodin 68-77 mitogen activated protein kinase 3 Rattus norvegicus 4-10 25774170-10 2012 Gastrodin could protect dopaminergic neurons via inhibition of interleukin-1beta expression and neuroinflammation in the substantia nigra. gastrodin 0-9 interleukin 1 beta Rattus norvegicus 63-80 21833534-7 2012 The inhibitory effect of gastrodin on cardiac hypertrophy is mediated by ERK1/2 signaling and GATA-4 activation. gastrodin 25-34 mitogen-activated protein kinase 3 Mus musculus 73-79 23558999-9 2012 This study also showed that a single treatment with GE extracts, gastrodin, or 4HBA induced the expression of GRP78, a marker for enhanced protein folding machinery, suggesting a protective mechanism for GE against beta-amyloid. gastrodin 65-74 heat shock protein 5 Mus musculus 110-115 21833534-7 2012 The inhibitory effect of gastrodin on cardiac hypertrophy is mediated by ERK1/2 signaling and GATA-4 activation. gastrodin 25-34 GATA binding protein 4 Mus musculus 94-100 21833534-8 2012 Further studies showed that gastrodin attenuated fibrosis and collagen synthesis through abrogating ERK1/2 signaling pathway. gastrodin 28-37 mitogen-activated protein kinase 3 Mus musculus 100-106 21833534-9 2012 Therefore, these findings indicated that gastrodin, which is a potentially safe and inexpensive therapy for clinical use, has protective potential in targeting cardiac hypertrophy and fibrosis through suppression of ERK1/2 signaling. gastrodin 41-50 mitogen-activated protein kinase 3 Mus musculus 216-222 22375417-2 2011 In present study, the effects of gastrodin on calcitonin gene-related peptide (CGRP) and phosphorylated extracellular signal-regulated kinase1/2 (pERK1/2) expression were observed in rat trigeminal ganglion (TG) after in vitro organ culture to explore the underlying intracellular mechanism of gastrodin on primary vascular-associated headache. gastrodin 33-42 calcitonin-related polypeptide alpha Rattus norvegicus 46-77 22375417-2 2011 In present study, the effects of gastrodin on calcitonin gene-related peptide (CGRP) and phosphorylated extracellular signal-regulated kinase1/2 (pERK1/2) expression were observed in rat trigeminal ganglion (TG) after in vitro organ culture to explore the underlying intracellular mechanism of gastrodin on primary vascular-associated headache. gastrodin 33-42 calcitonin-related polypeptide alpha Rattus norvegicus 79-83 22375417-2 2011 In present study, the effects of gastrodin on calcitonin gene-related peptide (CGRP) and phosphorylated extracellular signal-regulated kinase1/2 (pERK1/2) expression were observed in rat trigeminal ganglion (TG) after in vitro organ culture to explore the underlying intracellular mechanism of gastrodin on primary vascular-associated headache. gastrodin 33-42 mitogen activated protein kinase 3 Rattus norvegicus 104-144 21765922-0 2011 Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. gastrodin 0-9 nitric oxide synthase 2, inducible Mus musculus 33-54 22375417-4 2011 Only at 5 or 10 mmol L(-1) concentration, gastrodin demonstrated significantly concentration-dependent reduction of CGRP-ir (+) expression and its action closed to 1.2 mmol L(-1) sumatriptan succinate. gastrodin 42-51 calcitonin-related polypeptide alpha Rattus norvegicus 116-120 22375417-6 2011 The optimal concentration of gastrodin (5 and 10 mmol L(-1)) similarly inhibited CGRP-mRNA expression level separately compared with 1.2 mmol L(-1) sumatriptan succinate and 10 micromol L(-1) flunarizine hydrochloride, which was quantitatively analyzed by real-time PCR (RT-PCR). gastrodin 29-38 calcitonin-related polypeptide alpha Rattus norvegicus 81-85 22375417-7 2011 pERK1/2 level was examined by Western blotting after co-cultured with optimal concentration of gastrodin and effective specific ERK1/2 pathway inhibitors PD98059, U0126. gastrodin 95-104 mitogen activated protein kinase 3 Rattus norvegicus 1-7 22375417-9 2011 It suggests ERK1/2 signaling transduction pathway may be involved in gastrodin intracellular mechanism. gastrodin 69-78 mitogen activated protein kinase 3 Rattus norvegicus 12-18 22375417-10 2011 This study indicates gastrodin (5 and 10 mmol L(-1)) can remarkably reduce CGRP-ir (+) neuron, CGRP-mRNA and pERK1/2 expression level in cultured rat TG, with its actions similar to the effective concentration of sumatriptan succinate, flunarizine hydrochloride and specific ERK1/2 pathway blocker. gastrodin 21-30 calcitonin-related polypeptide alpha Rattus norvegicus 75-79 22375417-10 2011 This study indicates gastrodin (5 and 10 mmol L(-1)) can remarkably reduce CGRP-ir (+) neuron, CGRP-mRNA and pERK1/2 expression level in cultured rat TG, with its actions similar to the effective concentration of sumatriptan succinate, flunarizine hydrochloride and specific ERK1/2 pathway blocker. gastrodin 21-30 calcitonin-related polypeptide alpha Rattus norvegicus 95-99 22375417-10 2011 This study indicates gastrodin (5 and 10 mmol L(-1)) can remarkably reduce CGRP-ir (+) neuron, CGRP-mRNA and pERK1/2 expression level in cultured rat TG, with its actions similar to the effective concentration of sumatriptan succinate, flunarizine hydrochloride and specific ERK1/2 pathway blocker. gastrodin 21-30 mitogen activated protein kinase 3 Rattus norvegicus 110-116 21765922-0 2011 Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. gastrodin 0-9 prostaglandin-endoperoxide synthase 2 Mus musculus 56-72 21765922-0 2011 Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. gastrodin 0-9 mitogen-activated protein kinase 1 Mus musculus 144-148 21765922-8 2011 In addition, gastrodin blocked LPS-induced phosphorylation of inhibitor kappaB-alpha (IkappaB-alpha) (and hence the activation of NF-kappaB) and of CREB, respectively. gastrodin 13-22 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 86-99 21765922-8 2011 In addition, gastrodin blocked LPS-induced phosphorylation of inhibitor kappaB-alpha (IkappaB-alpha) (and hence the activation of NF-kappaB) and of CREB, respectively. gastrodin 13-22 cAMP responsive element binding protein 1 Mus musculus 148-152 18652355-1 2008 OBJECTIVE: To investigate the effect of gastrodine on the expression of NR1 mRNA of NMDA receptor in cultured rat cerebral cortical neurons injury induced by hypoxia. gastrodin 40-50 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 72-75 19291610-7 2009 Our results showed that lead exposure significantly impaired synaptic plasticity in the hippocampal CA1 region and that gastrodin can effectively rescue these lead-induced impairments. gastrodin 120-129 carbonic anhydrase 1 Rattus norvegicus 100-103 19777841-0 2009 [Gastrodine represses expression of IL-1 beta, IL-6 induced by hyperglycemia in gitter cells]. gastrodin 1-11 interleukin 1 beta Mus musculus 36-45 19777841-0 2009 [Gastrodine represses expression of IL-1 beta, IL-6 induced by hyperglycemia in gitter cells]. gastrodin 1-11 interleukin 6 Mus musculus 47-51 19777841-2 2009 The aim of this study is to evaluate the inhibitory effect of Gastrodine on the expression of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) in culturing for gitter cells (BV-2 cells) induced by high concentration of glucose. gastrodin 62-72 interleukin 1 beta Mus musculus 94-112 19777841-2 2009 The aim of this study is to evaluate the inhibitory effect of Gastrodine on the expression of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) in culturing for gitter cells (BV-2 cells) induced by high concentration of glucose. gastrodin 62-72 interleukin 1 beta Mus musculus 114-123 19777841-2 2009 The aim of this study is to evaluate the inhibitory effect of Gastrodine on the expression of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) in culturing for gitter cells (BV-2 cells) induced by high concentration of glucose. gastrodin 62-72 interleukin 6 Mus musculus 126-139 19777841-2 2009 The aim of this study is to evaluate the inhibitory effect of Gastrodine on the expression of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) in culturing for gitter cells (BV-2 cells) induced by high concentration of glucose. gastrodin 62-72 interleukin 6 Mus musculus 141-145 19777841-8 2009 The supernatant protein of IL-1 beta is higher in HCG group than control group (119.53 +/- 15.91) ng x L(-1) vs (25.74 +/- 15.72) ng x L(-1) (P < 0.01), but lower in the gastrodine groups than HCG LG (99.32 +/- 19.66) ng x L(-1), MG (76.94 +/- 17.16) ng x L(-1), HG (88.35 +/- 18.72) ng x L(-1) vs (119.53 +/-15.91) ng x L(-1) (P < 0.05). gastrodin 173-183 interleukin 1 beta Mus musculus 27-36 19777841-9 2009 The supernatant protein of IL-6 protein also higher in HCG than control group (393.7 +/- 17.51) ng x L(-1) vs (125.85 +/- 36.62) ng x L(-1) (P < 0.01), and lower in the gastrodine groups than HCG (LG 327.06 +/- 23.53) ng x L(-1), MG (217.36 +/- 28.81) ng x L(-1), HG (263.17 +/- 22.32) ng x L(-1) vs (393.7 +/- 17.51) ng x L(-1), P < 0.05). gastrodin 172-182 interleukin 6 Mus musculus 27-31 19777841-10 2009 The mRNA expression of IL-1 beta was increased significantly higher in HCG than control group (2.77 +/- 0.29) vs (1.13 +/- 0.27) (P < 0.05), but decreased significantly in gastrodine groups than HCG LGA (2.66 +/- 0.31), MGA (2.1 +/- 0.41), HGA (2.4 +/- 0.28) vs (2.77 +/- 0.29) (P < 0.05). gastrodin 175-185 interleukin 1 beta Mus musculus 23-32 19777841-11 2009 The mRNA Expression of IL-6 was higher in HCG than control group (3.97 +/- 0.33) vs (1.05 +/- 0.13) (P < 0.05, but lower in gastrodine groups than HCG LG (3.28 +/- 0.3), MG (2.65 +/- 0.33), HG (3.04 +/- 0.26), vs (3.97 +/- 0.33) (P < 0.05). gastrodin 127-137 interleukin 6 Mus musculus 23-27 19777841-12 2009 CONCLUSION: Gastrodine can inhibit the expression of IL-1 beta, IL-6 in cultured BV-2 cells induced by high concentration of glucose. gastrodin 12-22 interleukin 1 beta Mus musculus 53-62 19777841-12 2009 CONCLUSION: Gastrodine can inhibit the expression of IL-1 beta, IL-6 in cultured BV-2 cells induced by high concentration of glucose. gastrodin 12-22 interleukin 6 Mus musculus 64-68 18652355-0 2008 [Expression of NR1 mRNA of NMDA receptor by gastrodine on hypoxia injury in cultured rat cerebral cortical neurons]. gastrodin 44-54 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 15-18 18652355-5 2008 RESULT: The expression of NR1 mRNA increased markedly in hypoxia and hypoglucose injured cells, the increased expression can be weakened by gastrodine, more significant effect was found in the concentration of 26 mg x L(-1) 52 mg x L(-1). gastrodin 140-150 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 26-29 18652355-6 2008 CONCLUSION: Gastrodine may act as a neuro - protector by weakening the expression of NR1 mRNA in cultured rat cerebral cortical neurons injury induced by hypoxia and hypoglucose. gastrodin 12-22 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 85-88 16847996-0 2006 Gastrodin interaction with human fibrinogen: anticoagulant effects and binding studies. gastrodin 0-9 fibrinogen beta chain Homo sapiens 33-43