PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1815072-3	1991	In these cells, protopanaxadiol (PPD), which is an aglycon of Rh2, increased inversely with the decrease in Rh2 as a result of deglycosylation by the cells.	protopanaxadiol	16-31	Rh associated glycoprotein	Homo sapiens	62-65
1815072-3	1991	In these cells, protopanaxadiol (PPD), which is an aglycon of Rh2, increased inversely with the decrease in Rh2 as a result of deglycosylation by the cells.	protopanaxadiol	16-31	Rh associated glycoprotein	Homo sapiens	108-111
1815072-3	1991	In these cells, protopanaxadiol (PPD), which is an aglycon of Rh2, increased inversely with the decrease in Rh2 as a result of deglycosylation by the cells.	protopanaxadiol	33-36	Rh associated glycoprotein	Homo sapiens	62-65
1815072-3	1991	In these cells, protopanaxadiol (PPD), which is an aglycon of Rh2, increased inversely with the decrease in Rh2 as a result of deglycosylation by the cells.	protopanaxadiol	33-36	Rh associated glycoprotein	Homo sapiens	108-111
1815072-5	1991	In a serum-free medium, both Rh2 and PPD were incorporated within 1.5 h. The uptake rate constant of Rh2 (1.20 +/- 0.20 h-1) was not significantly different from that of PPD (1.02 +/- 0.15 h-1), but the release rate constant of PPD (2.12 +/- 0.38 h-1) was significantly lower than that of Rh2 (3.03 +/- 0.57 h-1).	protopanaxadiol	37-40	Rh associated glycoprotein	Homo sapiens	101-104
1804549-3	1991	In order to clarify some similarities and differences of decomposition modes between 20(S)-protopanaxadiol (20(S)-ppd) saponins, represented by ginsenoside Rb1 (Rb1) and ginsenoside Rb2 (Rb2), the decompositions of Rb1 and Rb2 in the rat gastrointestinal tract, 0.1 N HCl and crude hesperidinase were investigated in detail.	protopanaxadiol	108-117	RB transcriptional corepressor 1	Rattus norvegicus	156-159
1815072-5	1991	In a serum-free medium, both Rh2 and PPD were incorporated within 1.5 h. The uptake rate constant of Rh2 (1.20 +/- 0.20 h-1) was not significantly different from that of PPD (1.02 +/- 0.15 h-1), but the release rate constant of PPD (2.12 +/- 0.38 h-1) was significantly lower than that of Rh2 (3.03 +/- 0.57 h-1).	protopanaxadiol	37-40	Rh associated glycoprotein	Homo sapiens	101-104
34665516-1	2021	Ginsenosides, including Rb 1 , Rb 2 , Rb 3 and Rc, belong to protopanaxadiol-type saponins in Panax ginseng C. A. Mey.	protopanaxadiol	61-76	RB transcriptional corepressor 1	Homo sapiens	24-28
34369901-0	2021	Protopanaxadiol and protopanaxatriol ginsenosides can protect against aconitine-induced injury in H9c2 cells by maintaining calcium homeostasis and activating the AKT pathway.	protopanaxadiol	0-15	AKT serine/threonine kinase 1	Rattus norvegicus	163-166
34749235-0	2021	Ginsenoside (20S)-protopanaxatriol induces non-protective autophagy and apoptosis by inhibiting Akt/mTOR signaling pathway in triple-negative breast cancer cells.	protopanaxadiol	13-34	thymoma viral proto-oncogene 1	Mus musculus	96-99
34749235-0	2021	Ginsenoside (20S)-protopanaxatriol induces non-protective autophagy and apoptosis by inhibiting Akt/mTOR signaling pathway in triple-negative breast cancer cells.	protopanaxadiol	13-34	mechanistic target of rapamycin kinase	Mus musculus	100-104
34338601-2	2021	UGT1A3 inhibition by CK and PPD was competitive with Ki values of 17.4 and 1.21 muM, respectively, and inhibition by PPT was non-competitive with a Ki value of 8.07 muM in HLMs.	protopanaxadiol	28-31	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	0-6
35058733-1	2022	Background: 20(S)-protopanaxadiol (20(S)-PPD), one of the main active metabolites of ginseng, performs a broad spectrum of anti-tumor effects.	protopanaxadiol	14-33	argonaute RISC catalytic component 2	Homo sapiens	41-44
35600856-1	2022	Ginsenoside Rh2 (G-Rh2), a rare protopanaxadiol (PPD)-type triterpene saponin, from Panax ginseng has anti-proliferation, anti-invasion, and anti-metastatic activity.	protopanaxadiol	32-47	Rh associated glycoprotein	Homo sapiens	12-15
35442561-0	2022	Photoaffinity labeling-based chemoproteomic strategy reveals RBBP4 as a cellular target of protopanaxadiol against colorectal cancer cells.	protopanaxadiol	91-106	RB binding protein 4, chromatin remodeling factor	Homo sapiens	61-66
33841003-1	2021	Backgroud: Ginsenoside compound K (GK) is a major metabolite of protopanaxadiol-type ginsenosides and has remarkable anticancer activities in vitro and in vivo.	protopanaxadiol	64-79	glycerol kinase	Homo sapiens	35-37
33786848-0	2021	Protopanaxadiol alleviates neuropathic pain by spinal microglial dynorphin A expression following glucocorticoid receptor activation.	protopanaxadiol	0-15	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	98-121
33841013-0	2021	20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis.	protopanaxadiol	0-21	presenilin 1	Mus musculus	78-81
33437164-11	2021	Conclusion: 20(S)-PPD inhibits endometrial cancer cell proliferation by inducing cell death via a caspase-mediated apoptosis pathway.	protopanaxadiol	12-21	caspase 9	Homo sapiens	98-105
33128348-0	2020	20(S)-Protopanaxadiol inhibits epithelial-mesenchymal transition by promoting retinoid X receptor alpha in human colorectal carcinoma cells.	protopanaxadiol	0-21	retinoid X receptor alpha	Homo sapiens	78-103
33088689-6	2020	The results showed that the concentrations of protopanaxadiol-type (PPD) ginsenosides (Rb1, Rb2/Rb3, Rc, and Rd) in both plasma and tumors, were higher than those of protopanaxatriol-type (Rg1 and Re) and oleanane-type (Ro) ginsenosides.	protopanaxadiol	46-61	RB transcriptional corepressor 1	Mus musculus	87-90
32738969-2	2020	20(S)-protopanaxadiol [20(S)-PPD] is an activator of CK-MM and exerts an anti-fatigue effect.	protopanaxadiol	0-21	creatine kinase, M-type	Homo sapiens	53-58
32738969-2	2020	20(S)-protopanaxadiol [20(S)-PPD] is an activator of CK-MM and exerts an anti-fatigue effect.	protopanaxadiol	23-32	creatine kinase, M-type	Homo sapiens	53-58
32738969-9	2020	We demonstrated that 20(S)-PPD was the best activator of CK-MM among the 12 dammarane-type compounds.	protopanaxadiol	21-30	creatine kinase, M-type	Homo sapiens	57-62
33088689-6	2020	The results showed that the concentrations of protopanaxadiol-type (PPD) ginsenosides (Rb1, Rb2/Rb3, Rc, and Rd) in both plasma and tumors, were higher than those of protopanaxatriol-type (Rg1 and Re) and oleanane-type (Ro) ginsenosides.	protopanaxadiol	46-61	RB transcriptional corepressor like 2	Mus musculus	92-95
33088689-6	2020	The results showed that the concentrations of protopanaxadiol-type (PPD) ginsenosides (Rb1, Rb2/Rb3, Rc, and Rd) in both plasma and tumors, were higher than those of protopanaxatriol-type (Rg1 and Re) and oleanane-type (Ro) ginsenosides.	protopanaxadiol	46-61	stathmin-like 4	Mus musculus	96-99
33088689-6	2020	The results showed that the concentrations of protopanaxadiol-type (PPD) ginsenosides (Rb1, Rb2/Rb3, Rc, and Rd) in both plasma and tumors, were higher than those of protopanaxatriol-type (Rg1 and Re) and oleanane-type (Ro) ginsenosides.	protopanaxadiol	46-61	protein phosphatase 1, regulatory subunit 3A	Mus musculus	189-192
32642409-0	2020	20(S)-Protopanaxatriol promotes the binding of P53 and DNA to regulate the antitumor network via multiomic analysis.	protopanaxadiol	0-22	tumor protein p53	Homo sapiens	47-50
32662640-0	2020	20S-Protopanaxatriol Ameliorates Hepatic Fibrosis, Potentially Involving FXR-Mediated Inflammatory Signaling Cascades.	protopanaxadiol	0-20	nuclear receptor subfamily 1, group H, member 4	Mus musculus	73-76
32372868-5	2020	Subsequently, 20(S)-protopanaxadiol (PPD), which is a ginsenoside metabolite and displayed the strongest interaction with CK-MM in the study, was selected as a representative to confirm direct binding and its biological importance.	protopanaxadiol	16-35	creatine kinase, M-type	Homo sapiens	122-127
32372868-5	2020	Subsequently, 20(S)-protopanaxadiol (PPD), which is a ginsenoside metabolite and displayed the strongest interaction with CK-MM in the study, was selected as a representative to confirm direct binding and its biological importance.	protopanaxadiol	37-40	creatine kinase, M-type	Homo sapiens	122-127
32372871-5	2020	However, ginsenoside Rk1 inhibited NMDARs most effectively among the five compounds (Rg3, Rg5, Rk1, Rg5/Rk1 mixture, and protopanaxadiol) tested in cultured hippocampal neurons.	protopanaxadiol	121-136	kallikrein 1-related peptidase B3	Rattus norvegicus	21-24
31726169-3	2020	In this study, Yjic from B. subtilis 168 was found to synthesize ginsenoside F12 (3beta,12beta-Di-O-Glc-protopanaxadiol) and Rh2 at a ratio of 7:3.	protopanaxadiol	82-119	polyphenols TDP-rhamnosyltransferase, promiscuous	Bacillus subtilis subsp. subtilis str. 168	15-19
32415270-0	2020	Protopanaxadiol ginsenoside Rd protects against NMDA receptor-mediated excitotoxicity by attenuating calcineurin-regulated DAPK1 activity.	protopanaxadiol	0-15	death associated protein kinase 1	Rattus norvegicus	123-128
32326560-1	2020	In this study, we aimed to develop a 20(S)-protopanaxadiol (PPD)-loaded self-nanoemulsifying drug delivery system (SNEDDS) preconcentrate (PSP) using comprehensive ternary phase diagrams for enhanced solubility, physical stability, dissolution, and bioavailability.	protopanaxadiol	42-58	persephin	Homo sapiens	139-142
32326560-1	2020	In this study, we aimed to develop a 20(S)-protopanaxadiol (PPD)-loaded self-nanoemulsifying drug delivery system (SNEDDS) preconcentrate (PSP) using comprehensive ternary phase diagrams for enhanced solubility, physical stability, dissolution, and bioavailability.	protopanaxadiol	60-63	persephin	Homo sapiens	139-142
31926987-8	2020	Further, PPT inhibited IL-1beta secretion in both LPS-induced septic shock and MSU-induced mouse peritonitis models.	protopanaxadiol	9-12	interleukin 1 alpha	Mus musculus	23-31
31991384-2	2020	A novel 20(S)-Rh2 derivative, 2-Deoxy-Rh2 was synthesized and hybridized with protopanaxadiol and 2-deoxy-glucose in an attempt to enhance the anticancer activity.	protopanaxadiol	78-93	Rh associated glycoprotein	Homo sapiens	14-17
31805304-0	2020	20(S)-Protopanaxadiol blocks cell cycle progression by targeting epidermal growth factor receptor.	protopanaxadiol	0-21	epidermal growth factor receptor	Homo sapiens	65-97
31805304-1	2020	20(S)-Protopanaxadiol [20(S)-PPD], one of the metabolites of ginsenosides, was investigated to determine its potential mechanism for targeting to epidermal growth factor receptor (EGFR) pathway in lung cancer cell A549.	protopanaxadiol	0-21	epidermal growth factor receptor	Homo sapiens	146-178
31805304-1	2020	20(S)-Protopanaxadiol [20(S)-PPD], one of the metabolites of ginsenosides, was investigated to determine its potential mechanism for targeting to epidermal growth factor receptor (EGFR) pathway in lung cancer cell A549.	protopanaxadiol	0-21	epidermal growth factor receptor	Homo sapiens	180-184
31816825-1	2019	This study aimed to evaluate whether ginsenosides Rb1 (20-S-protopanaxadiol aglycon) and Rg1 (20-S-protopanaxatriol aglycon) have mitochondrial protective effects against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in primary mouse astrocytes and to explore the mechanisms involved.	protopanaxadiol	55-75	RB transcriptional corepressor 1	Mus musculus	50-53
32095096-1	2020	Background: Ginsenoside Rb1 (Rb1), one of the most abundant protopanaxadiol-type ginsenosides, exerts excellent neuroprotective effects even though it has low intracephalic exposure.	protopanaxadiol	60-75	RB transcriptional corepressor 1	Rattus norvegicus	24-27
32095096-1	2020	Background: Ginsenoside Rb1 (Rb1), one of the most abundant protopanaxadiol-type ginsenosides, exerts excellent neuroprotective effects even though it has low intracephalic exposure.	protopanaxadiol	60-75	RB transcriptional corepressor 1	Rattus norvegicus	29-32
31780945-1	2019	20(S)-ginsenoside Rh2 (Rh2), a well-known protopanaxadiol-type ginsenoside from Panax ginseng has especially gained attention for its anticancer activities on various types of human cancer cells.	protopanaxadiol	42-57	Rh associated glycoprotein	Homo sapiens	18-21
31445083-5	2019	Harnessing the yeast ER for metabolic engineering, we ultimately increased the production of squalene and cytochrome P450-mediated protopanaxadiol by 71-fold and 8-fold, compared to their respective control strains without overexpression of INO2.	protopanaxadiol	131-146	Ino2p	Saccharomyces cerevisiae S288C	241-245
31780945-1	2019	20(S)-ginsenoside Rh2 (Rh2), a well-known protopanaxadiol-type ginsenoside from Panax ginseng has especially gained attention for its anticancer activities on various types of human cancer cells.	protopanaxadiol	42-57	Rh associated glycoprotein	Homo sapiens	23-26
31623159-0	2019	20(S)-Protopanaxadiol Saponins Mainly Contribute to the Anti-Atherogenic Effects of Panax notoginseng in ApoE Deficient Mice.	protopanaxadiol	0-30	apolipoprotein E	Mus musculus	105-109
31623159-3	2019	According to different sapogenin, PNS are generally classified into 20(S)-protopanaxadiol saponins (PDS) and 20(S)-protopanaxatriol saponins (PTS).	protopanaxadiol	68-98	solute carrier family 26, member 4	Mus musculus	100-103
31431619-0	2019	Protopanaxadiol inhibits epithelial-mesenchymal transition of hepatocellular carcinoma by targeting STAT3 pathway.	protopanaxadiol	0-15	signal transducer and activator of transcription 3	Homo sapiens	100-105
31431619-10	2019	PPD also inhibited tumor volume and tumor lung metastasis in PLC/PRF/5 xenograft model.	protopanaxadiol	0-3	heparan sulfate proteoglycan 2	Homo sapiens	61-64
31431619-11	2019	In conclusion, PPD can inhibit the proliferation and metastasis of HCC cells through the STAT3/Twist1 pathway.	protopanaxadiol	15-18	signal transducer and activator of transcription 3	Homo sapiens	89-94
31431619-11	2019	In conclusion, PPD can inhibit the proliferation and metastasis of HCC cells through the STAT3/Twist1 pathway.	protopanaxadiol	15-18	twist family bHLH transcription factor 1	Homo sapiens	95-101
31308818-7	2019	ABCC4 rs1151471 and CFTR rs2283054 influenced the pharmacokinetics of 20(S)-PPD.	protopanaxadiol	72-79	ATP binding cassette subfamily C member 4	Homo sapiens	0-5
31154268-2	2019	This study investigated the effects of the most abundant constituents of P. ginseng-protopanaxatriol ginsenoside Rg1 and protopanaxadiol ginsenoside Rb1-on sleep in rats.	protopanaxadiol	121-136	RB transcriptional corepressor 1	Rattus norvegicus	149-152
31308818-7	2019	ABCC4 rs1151471 and CFTR rs2283054 influenced the pharmacokinetics of 20(S)-PPD.	protopanaxadiol	72-79	CF transmembrane conductance regulator	Homo sapiens	20-24
30327544-9	2019	The protopanaxadiol-type ginsenosides, ginsenosides without any sugar attachment at C-20 (except ginsenoside Rf), and ginsenoside Ro inhibited OATP1B3 more potently (IC50, 0.2-3.5 micromol/L) than the other ginsenosides (>=22.6 micromol/L).	protopanaxadiol	4-19	solute carrier organic anion transporter family member 1B3	Homo sapiens	143-150
30380571-13	2019	Both the 20S-epimers [2, 3: , and 20(S)-protopanaxadiol] and 20R-epimers [9, 10: , and 20(R)-protopanaxadiol] inhibited the release of inflammatory cytokine interleukin-6, but mainly the 20S-epimers [2, 3: , and 20(S)-protopanaxadiol] increased the release of anti-inflammatory mediator interleukin-10.	protopanaxadiol	36-55	interleukin 6	Mus musculus	157-170
30259568-0	2019	20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway.	protopanaxadiol	0-21	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	100-104
30259568-0	2019	20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway.	protopanaxadiol	0-21	eukaryotic translation initiation factor 2A	Homo sapiens	105-114
30259568-0	2019	20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway.	protopanaxadiol	0-21	activating transcription factor 4	Homo sapiens	115-119
30259568-11	2019	Furthermore, siRNA-mediated knockdown of PERK or ATF4 inhibited the induction of CHOP expression and 20(s)-PPD-induced apoptosis.	protopanaxadiol	107-110	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	41-45
30259568-11	2019	Furthermore, siRNA-mediated knockdown of PERK or ATF4 inhibited the induction of CHOP expression and 20(s)-PPD-induced apoptosis.	protopanaxadiol	107-110	activating transcription factor 4	Homo sapiens	49-53
30735802-0	2019	Ginsenoside 20(S)-protopanaxadiol inhibits triple-negative breast cancer metastasis in vivo by targeting EGFR-mediated MAPK pathway.	protopanaxadiol	14-33	epidermal growth factor receptor	Homo sapiens	105-109
30591629-0	2018	Potential Dissociative Glucocorticoid Receptor Activity for Protopanaxadiol and Protopanaxatriol.	protopanaxadiol	60-75	nuclear receptor subfamily 3 group C member 1	Homo sapiens	23-46
30713497-0	2018	20(S)-Protopanaxadiol Inhibits Titanium Particle-Induced Inflammatory Osteolysis and RANKL-Mediated Osteoclastogenesis via MAPK and NF-kappaB Signaling Pathways.	protopanaxadiol	2-21	TNF superfamily member 11	Homo sapiens	85-90
30591629-8	2018	In this study applying induced-fit docking analysis, luciferase assay, immunofluorescence, and Western blot analysis, we showed that protopanaxadiol and more effectively protopanaxatriol are capable of binding to GR to activate its nuclear translocation, and to suppress the nuclear factor-kappa beta activity in GR-positive HeLa and HEK293 cells, but not in GR-low level COS-7 cells.	protopanaxadiol	133-148	nuclear receptor subfamily 3 group C member 1	Homo sapiens	213-215
30591629-8	2018	In this study applying induced-fit docking analysis, luciferase assay, immunofluorescence, and Western blot analysis, we showed that protopanaxadiol and more effectively protopanaxatriol are capable of binding to GR to activate its nuclear translocation, and to suppress the nuclear factor-kappa beta activity in GR-positive HeLa and HEK293 cells, but not in GR-low level COS-7 cells.	protopanaxadiol	133-148	nuclear receptor subfamily 3 group C member 1	Homo sapiens	313-315
30591629-8	2018	In this study applying induced-fit docking analysis, luciferase assay, immunofluorescence, and Western blot analysis, we showed that protopanaxadiol and more effectively protopanaxatriol are capable of binding to GR to activate its nuclear translocation, and to suppress the nuclear factor-kappa beta activity in GR-positive HeLa and HEK293 cells, but not in GR-low level COS-7 cells.	protopanaxadiol	133-148	nuclear receptor subfamily 3 group C member 1	Homo sapiens	313-315
30591629-10	2018	Thus, our results indicate that protopanaxadiol and protopanaxatriol could be considered as potent and selective GR agonist.	protopanaxadiol	32-47	nuclear receptor subfamily 3 group C member 1	Homo sapiens	113-115
30344740-0	2018	A 20(S)-protopanaxadiol derivative PPD12 reverses ABCB1-mediated multidrug resistance with oral bioavailability and low toxicity.	protopanaxadiol	4-23	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	50-55
30344740-2	2018	To inhibit ABCB1 activity in MDR cancer cells, the authors previously designed and synthesized a derivative from 20(S)-protopanaxadiol (PPD) PPD12 and verified its efficacy in ABCB1-overexpressing cancer cells.	protopanaxadiol	115-134	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	11-16
30344740-2	2018	To inhibit ABCB1 activity in MDR cancer cells, the authors previously designed and synthesized a derivative from 20(S)-protopanaxadiol (PPD) PPD12 and verified its efficacy in ABCB1-overexpressing cancer cells.	protopanaxadiol	115-134	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	29-32
30344740-2	2018	To inhibit ABCB1 activity in MDR cancer cells, the authors previously designed and synthesized a derivative from 20(S)-protopanaxadiol (PPD) PPD12 and verified its efficacy in ABCB1-overexpressing cancer cells.	protopanaxadiol	115-134	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	176-181
30337812-10	2018	Conclusion: The MEH formulation developed in this study could serve as an effective topical delivery system for poorly soluble ginsenosides and their deglycosylated metabolites, including 20S-PPD.	protopanaxadiol	188-195	epoxide hydrolase 1, microsomal	Mus musculus	16-19
29765513-0	2018	20(S)-protopanaxadiol regio-selectively targets androgen receptor: anticancer effects in castration-resistant prostate tumors.	protopanaxadiol	2-21	androgen receptor	Homo sapiens	48-65
29765513-1	2018	We have explored the effects of 20(S)-protopanaxadiol (aPPD), a naturally derived ginsenoside, against androgen receptor (AR) positive castration resistant prostate cancer (CRPC) xenograft tumors and have examined its interactions with AR.	protopanaxadiol	32-53	androgen receptor	Homo sapiens	103-120
29765513-1	2018	We have explored the effects of 20(S)-protopanaxadiol (aPPD), a naturally derived ginsenoside, against androgen receptor (AR) positive castration resistant prostate cancer (CRPC) xenograft tumors and have examined its interactions with AR.	protopanaxadiol	32-53	androgen receptor	Homo sapiens	122-124
29614812-0	2018	20(S)-Protopanaxadiol-Induced Apoptosis in MCF-7 Breast Cancer Cell Line through the Inhibition of PI3K/AKT/mTOR Signaling Pathway.	protopanaxadiol	6-21	AKT serine/threonine kinase 1	Homo sapiens	104-107
29614812-0	2018	20(S)-Protopanaxadiol-Induced Apoptosis in MCF-7 Breast Cancer Cell Line through the Inhibition of PI3K/AKT/mTOR Signaling Pathway.	protopanaxadiol	6-21	mechanistic target of rapamycin kinase	Homo sapiens	108-112
29614812-3	2018	Our research study aims were to investigate whether apoptosis of human breast cancer MCF-7 cells could be induced by 20(S)-PPD by targeting the Phosphatidylinositol 3-kinase/Protein kinase B/Mammalian target of rapamycin (PI3K/AKT/mTOR) signal pathway in vitro and in vivo.	protopanaxadiol	119-126	protein tyrosine kinase 2 beta	Homo sapiens	174-190
29614812-3	2018	Our research study aims were to investigate whether apoptosis of human breast cancer MCF-7 cells could be induced by 20(S)-PPD by targeting the Phosphatidylinositol 3-kinase/Protein kinase B/Mammalian target of rapamycin (PI3K/AKT/mTOR) signal pathway in vitro and in vivo.	protopanaxadiol	119-126	mechanistic target of rapamycin kinase	Homo sapiens	191-220
29614812-3	2018	Our research study aims were to investigate whether apoptosis of human breast cancer MCF-7 cells could be induced by 20(S)-PPD by targeting the Phosphatidylinositol 3-kinase/Protein kinase B/Mammalian target of rapamycin (PI3K/AKT/mTOR) signal pathway in vitro and in vivo.	protopanaxadiol	119-126	AKT serine/threonine kinase 1	Homo sapiens	227-230
29614812-3	2018	Our research study aims were to investigate whether apoptosis of human breast cancer MCF-7 cells could be induced by 20(S)-PPD by targeting the Phosphatidylinositol 3-kinase/Protein kinase B/Mammalian target of rapamycin (PI3K/AKT/mTOR) signal pathway in vitro and in vivo.	protopanaxadiol	119-126	mechanistic target of rapamycin kinase	Homo sapiens	231-235
29614812-10	2018	Furthermore, overexpression or knockdown of mTOR could inhibit or promote the apoptotic effects of 20(S)-PPD.	protopanaxadiol	101-108	mechanistic target of rapamycin kinase	Homo sapiens	44-48
29614812-13	2018	PI3K/AKT/mTOR pathway-mediated apoptosis may be one of the potential mechanisms of 20(S)-PPD treatment.	protopanaxadiol	85-92	AKT serine/threonine kinase 1	Homo sapiens	5-8
29614812-13	2018	PI3K/AKT/mTOR pathway-mediated apoptosis may be one of the potential mechanisms of 20(S)-PPD treatment.	protopanaxadiol	85-92	mechanistic target of rapamycin kinase	Homo sapiens	9-13
29434714-10	2018	The percentage of Annexin V-fluoroscein isothyiocyanate positive cells were 3.73, 17.61, 23.44 and 65.43% in HepG2 cells treated with 0, 40, 50 and 60 microM of 20(S)-PPD, respectively.	protopanaxadiol	163-170	annexin A5	Homo sapiens	18-27
29197516-5	2018	Here we discovered that protopanaxadiol derivative 1-(3,4-dimethoxyphenethyl)-3-(3-dehydroxyl-20(s)-protopanaxadiol-3beta-yl)-urea (DDPU) effectively improved the activity of daily living (ADL) and cognitive deficits in APP/PS1 transgenic mice.	protopanaxadiol	24-39	presenilin 1	Mus musculus	224-227
29434714-12	2018	In addition, 20(S)-PPD inhibited the phosphorylation of protein kinase B (Akt; Ser473).	protopanaxadiol	15-22	AKT serine/threonine kinase 1	Homo sapiens	74-77
29434714-13	2018	The results indicate that 20(S)-PPD inhibits the viability of HepG2 cells and induces apoptosis in HepG2 cells by inhibiting the phosphoinositide-3-kinase/Akt pathway.	protopanaxadiol	28-35	AKT serine/threonine kinase 1	Homo sapiens	155-158
29133030-0	2018	20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice.	protopanaxadiol	2-21	early growth response 1	Mus musculus	150-155
29133030-0	2018	20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice.	protopanaxadiol	2-21	FBJ osteosarcoma oncogene	Mus musculus	157-162
29133030-0	2018	20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice.	protopanaxadiol	2-21	jun proto-oncogene	Mus musculus	167-172
28412215-2	2017	ETHNOPHARMACOLOGY RELEVANCE: Ginsenoside Rb1, a 20 (S)-protopanaxadiol, is a major active ingredient of Panax ginseng C.A.	protopanaxadiol	48-70	RB transcriptional corepressor 1	Rattus norvegicus	41-44
29207398-1	2018	OBJECTIVE: Ginsenosides, Rb1 and Rb3, are the major protopanaxadiol components of ginseng saponin.	protopanaxadiol	52-67	RB transcriptional corepressor 1	Rattus norvegicus	25-28
29207398-1	2018	OBJECTIVE: Ginsenosides, Rb1 and Rb3, are the major protopanaxadiol components of ginseng saponin.	protopanaxadiol	52-67	stathmin 4	Rattus norvegicus	33-36
28379603-0	2017	The Ginsenoside Derivative 20(S)-Protopanaxadiol Inhibits Solar Ultraviolet Light-Induced Matrix Metalloproteinase-1 Expression.	protopanaxadiol	29-48	matrix metallopeptidase 1	Homo sapiens	90-116
28379603-3	2017	In this study, 20(S)-protopanaxadiol (20(S)-PPD), an aglycone derivative of the Rb1 metabolite was investigated for its anti-wrinkle benefit and compared to GPPD and Rb1.	protopanaxadiol	15-36	RB transcriptional corepressor 1	Homo sapiens	80-83
29075038-0	2017	20(S)-Protopanaxadiol enhances angiogenesis via HIF-1alpha-mediated VEGF secretion by activating p70S6 kinase and benefits wound healing in genetically diabetic mice.	protopanaxadiol	2-21	hypoxia inducible factor 1, alpha subunit	Mus musculus	48-58
29075038-0	2017	20(S)-Protopanaxadiol enhances angiogenesis via HIF-1alpha-mediated VEGF secretion by activating p70S6 kinase and benefits wound healing in genetically diabetic mice.	protopanaxadiol	2-21	vascular endothelial growth factor A	Mus musculus	68-72
29075038-8	2017	Overall, our results revealed that PPD stimulated angiogenesis via HIF-1alpha-mediated VEGF expression by activating p70S6K through PI3K/Akt/mTOR and Raf/MEK/ERK signaling cascades, which suggests that the compound has potential use in wound healing therapy in patients suffering from DFUs.	protopanaxadiol	35-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-77
29075038-8	2017	Overall, our results revealed that PPD stimulated angiogenesis via HIF-1alpha-mediated VEGF expression by activating p70S6K through PI3K/Akt/mTOR and Raf/MEK/ERK signaling cascades, which suggests that the compound has potential use in wound healing therapy in patients suffering from DFUs.	protopanaxadiol	35-38	vascular endothelial growth factor A	Homo sapiens	87-91
29075038-8	2017	Overall, our results revealed that PPD stimulated angiogenesis via HIF-1alpha-mediated VEGF expression by activating p70S6K through PI3K/Akt/mTOR and Raf/MEK/ERK signaling cascades, which suggests that the compound has potential use in wound healing therapy in patients suffering from DFUs.	protopanaxadiol	35-38	ribosomal protein S6 kinase B1	Homo sapiens	117-123
29075038-8	2017	Overall, our results revealed that PPD stimulated angiogenesis via HIF-1alpha-mediated VEGF expression by activating p70S6K through PI3K/Akt/mTOR and Raf/MEK/ERK signaling cascades, which suggests that the compound has potential use in wound healing therapy in patients suffering from DFUs.	protopanaxadiol	35-38	AKT serine/threonine kinase 1	Homo sapiens	137-140
29075038-8	2017	Overall, our results revealed that PPD stimulated angiogenesis via HIF-1alpha-mediated VEGF expression by activating p70S6K through PI3K/Akt/mTOR and Raf/MEK/ERK signaling cascades, which suggests that the compound has potential use in wound healing therapy in patients suffering from DFUs.	protopanaxadiol	35-38	mechanistic target of rapamycin kinase	Homo sapiens	141-145
29075038-8	2017	Overall, our results revealed that PPD stimulated angiogenesis via HIF-1alpha-mediated VEGF expression by activating p70S6K through PI3K/Akt/mTOR and Raf/MEK/ERK signaling cascades, which suggests that the compound has potential use in wound healing therapy in patients suffering from DFUs.	protopanaxadiol	35-38	zinc fingers and homeoboxes 2	Homo sapiens	150-153
29075038-8	2017	Overall, our results revealed that PPD stimulated angiogenesis via HIF-1alpha-mediated VEGF expression by activating p70S6K through PI3K/Akt/mTOR and Raf/MEK/ERK signaling cascades, which suggests that the compound has potential use in wound healing therapy in patients suffering from DFUs.	protopanaxadiol	35-38	mitogen-activated protein kinase kinase 7	Homo sapiens	154-157
29075038-8	2017	Overall, our results revealed that PPD stimulated angiogenesis via HIF-1alpha-mediated VEGF expression by activating p70S6K through PI3K/Akt/mTOR and Raf/MEK/ERK signaling cascades, which suggests that the compound has potential use in wound healing therapy in patients suffering from DFUs.	protopanaxadiol	35-38	mitogen-activated protein kinase 1	Homo sapiens	158-161
32188210-7	2017	Interestingly, compound K, an intestinal bacterial metabolite of ginseng protopanaxadiol saponin, which has been proven to promote apoptosis of human hepatocellular carcinoma cells, was found to impede the down-regulation of EHHADH-AS1 in several liver cancer cell lines including HepG3B, Huh-7 and plc/prf/5 cells.	protopanaxadiol	73-88	EHHADH antisense RNA 1	Homo sapiens	225-235
32188210-7	2017	Interestingly, compound K, an intestinal bacterial metabolite of ginseng protopanaxadiol saponin, which has been proven to promote apoptosis of human hepatocellular carcinoma cells, was found to impede the down-regulation of EHHADH-AS1 in several liver cancer cell lines including HepG3B, Huh-7 and plc/prf/5 cells.	protopanaxadiol	73-88	MIR7-3 host gene	Homo sapiens	289-294
28458137-2	2017	These derivatives were effectively prepared from protopanaxadiol based on the modification of rings A and D. Among these compounds, ten were identified as selective 11beta-HSD1 inhibitors (IC50 range: 101-1047 nM, SI range: 8-169) which exhibited inhibitory activities against human or mouse 11beta-HSD1.	protopanaxadiol	49-64	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	165-176
28458137-2	2017	These derivatives were effectively prepared from protopanaxadiol based on the modification of rings A and D. Among these compounds, ten were identified as selective 11beta-HSD1 inhibitors (IC50 range: 101-1047 nM, SI range: 8-169) which exhibited inhibitory activities against human or mouse 11beta-HSD1.	protopanaxadiol	49-64	RNA, U1 small nuclear 1	Homo sapiens	283-303
28478658-5	2017	Scale-up production in a 10-L jar fermenter, using 60 g of the protopanaxadiol-type ginsenoside mixture from ginseng roots, produced 24 g of ginsenoside Rh2-MIX.	protopanaxadiol	63-78	Rh associated glycoprotein	Homo sapiens	153-156
28478658-5	2017	Scale-up production in a 10-L jar fermenter, using 60 g of the protopanaxadiol-type ginsenoside mixture from ginseng roots, produced 24 g of ginsenoside Rh2-MIX.	protopanaxadiol	63-78	Mix paired-like homeobox	Homo sapiens	157-160
28701883-0	2017	20S-Protopanaxadiol, an aglycosylated ginsenoside metabolite, induces hepatic stellate cell apoptosis through liver kinase B1-AMP-activated protein kinase activation.	protopanaxadiol	0-19	serine/threonine kinase 11	Homo sapiens	110-125
28479190-5	2017	The semi-rationally designed UGT51 presented an ~1800-fold enhanced catalytic efficiency (kcat/Km) for converting protopanaxadiol to ginsenoside Rh2 in vitro.	protopanaxadiol	114-129	sterol 3-beta-glucosyltransferase	Saccharomyces cerevisiae S288C	29-34
26757342-3	2016	Recently, an artificial biosynthetic pathway of protopanaxadiol was built in Saccharomyces cerevisiae by introducing a P. ginseng dammarenediol-II synthase, a P. ginseng cytochrome P450-type protopanaxadiol synthase (PPDS), and a Arabidopsis thaliana NADPH-cytochrome P450 reductase (ATR1).	protopanaxadiol	48-63	P450 reductase 1	Arabidopsis thaliana	284-288
26757342-6	2016	To overcome the obstacles in protopanaxadiol production, PPDS was modified through transmembrane domain truncation and self-sufficient PPDS-ATR1 fusion construction in this study.	protopanaxadiol	29-44	borate transporter	Saccharomyces cerevisiae S288C	140-144
27005621-0	2016	Identification of Human UDP-Glucuronosyltransferase 1A4 as the Major Isozyme Responsible for the Glucuronidation of 20(S)-Protopanaxadiol in Human Liver Microsomes.	protopanaxadiol	116-137	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	24-55
27005621-5	2016	In conclusion, PPD-3-O-beta-D-glucuronide was first identified as the principal glucuronidation metabolite of PPD in HLMs, which was catalyzed by UGT1A4.	protopanaxadiol	15-18	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	146-152
26528894-1	2016	Ginsenoside Rb3 has been proved to have antidepressant-like effects, which possesses 1 xylose and 3 glucose moieties with 20(S)-protopanaxadiol (PPD) as the aglycone.	protopanaxadiol	122-143	stathmin-like 4	Mus musculus	12-15
26528894-1	2016	Ginsenoside Rb3 has been proved to have antidepressant-like effects, which possesses 1 xylose and 3 glucose moieties with 20(S)-protopanaxadiol (PPD) as the aglycone.	protopanaxadiol	145-148	stathmin-like 4	Mus musculus	12-15
25297453-11	2015	The 20(S)-protopanaxadiol-type ginsenosides were potent inhibitors of OATP1B3.	protopanaxadiol	6-25	solute carrier organic anion transporter family member 1B3	Homo sapiens	70-77
26869828-10	2015	In addition, only G-Rg3 of protopanaxadiol in KRG-TS inhibited thrombin-induced platelet aggregation.	protopanaxadiol	27-42	coagulation factor II, thrombin	Homo sapiens	63-71
26043782-1	2015	AIMS: The antiphotoaging activities of ginsenoside Rb2 on the skin, one of the predominant protopanaxadiol-type ginsenosides, were evaluated in cultured human dermal fibroblasts.	protopanaxadiol	91-106	RB transcriptional corepressor like 2	Homo sapiens	51-54
25747994-3	2015	Orally administered ginsenoside Rb1 and Re are metabolized to 20(S)-protopanaxadiol (PPD) and compound K via ginsenoside Rd and 20(S)-protopanaxatriol (PPT) and ginsenoside Rh1 via ginsenoside Rg1 by gut microbiota, respectively.	protopanaxadiol	64-83	RB transcriptional corepressor 1	Mus musculus	32-35
25747994-3	2015	Orally administered ginsenoside Rb1 and Re are metabolized to 20(S)-protopanaxadiol (PPD) and compound K via ginsenoside Rd and 20(S)-protopanaxatriol (PPT) and ginsenoside Rh1 via ginsenoside Rg1 by gut microbiota, respectively.	protopanaxadiol	128-150	RB transcriptional corepressor 1	Mus musculus	32-35
25747994-3	2015	Orally administered ginsenoside Rb1 and Re are metabolized to 20(S)-protopanaxadiol (PPD) and compound K via ginsenoside Rd and 20(S)-protopanaxatriol (PPT) and ginsenoside Rh1 via ginsenoside Rg1 by gut microbiota, respectively.	protopanaxadiol	152-155	RB transcriptional corepressor 1	Mus musculus	32-35
25747994-3	2015	Orally administered ginsenoside Rb1 and Re are metabolized to 20(S)-protopanaxadiol (PPD) and compound K via ginsenoside Rd and 20(S)-protopanaxatriol (PPT) and ginsenoside Rh1 via ginsenoside Rg1 by gut microbiota, respectively.	protopanaxadiol	152-155	protein phosphatase 1, regulatory subunit 3A	Mus musculus	193-196
25774540-0	2015	Suppressive properties of ginsenoside Rb2, a protopanaxadiol-type ginseng saponin, on reactive oxygen species and matrix metalloproteinase-2 in UV-B-irradiated human dermal keratinocytes.	protopanaxadiol	45-60	RB transcriptional corepressor like 2	Homo sapiens	38-41
25774540-2	2015	The present work aimed to assess skin anti-photoaging properties of ginsenoside Rb2 (Rb2), one of the predominant protopanaxadiol-type ginsenosides, in human epidermal keratinocyte HaCaT cells under UV-B irradiation.	protopanaxadiol	114-129	RB transcriptional corepressor like 2	Homo sapiens	80-83
25774540-2	2015	The present work aimed to assess skin anti-photoaging properties of ginsenoside Rb2 (Rb2), one of the predominant protopanaxadiol-type ginsenosides, in human epidermal keratinocyte HaCaT cells under UV-B irradiation.	protopanaxadiol	114-129	RB transcriptional corepressor like 2	Homo sapiens	85-88
25405256-6	2015	20(S)-PPD, but not 20(R)-PPD, exhibited an inhibitory effect on UV-B-induced MMP-2 activity and expression in HaCaT cells.	protopanaxadiol	2-9	matrix metallopeptidase 2	Homo sapiens	77-82
25405256-7	2015	In brief, only 20(S)-PPD, a major metabolic product of PPD-type ginsenosides, inhibits UV-B-induced ROS and MMP-2 elevation, implying its stereospecific anti-photoaging activity on the skin.	protopanaxadiol	17-24	matrix metallopeptidase 2	Homo sapiens	108-113
25704023-0	2015	TRAIL pathway is associated with inhibition of colon cancer by protopanaxadiol.	protopanaxadiol	63-78	TNF superfamily member 10	Homo sapiens	0-5
24492721-1	2014	20(S)-Ginsenoside Rh2 (GRh2) and ginsenoside Rg3 (GRg3) are members of the protopanaxadiol family and have been investigated for possible chemopreventive activity.	protopanaxadiol	75-90	Rh associated glycoprotein	Homo sapiens	18-21
24887182-0	2014	Stereoselective property of 20(S)-protopanaxadiol ocotillol type epimers affects its absorption and also the inhibition of P-glycoprotein.	protopanaxadiol	28-49	ATP binding cassette subfamily B member 1	Homo sapiens	123-137
24648985-3	2013	The experimental results indicated that the native protopanaxadiol ginsenosides Rb1 and Rb2 inhibited the proliferation of the colorectal cancer cells in a dose-dependent manner.	protopanaxadiol	51-66	RB transcriptional corepressor 1	Homo sapiens	80-83
23889969-0	2013	Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells.	protopanaxadiol	58-73	sphingomyelin phosphodiesterase 3	Homo sapiens	0-26
24648985-3	2013	The experimental results indicated that the native protopanaxadiol ginsenosides Rb1 and Rb2 inhibited the proliferation of the colorectal cancer cells in a dose-dependent manner.	protopanaxadiol	51-66	RB transcriptional corepressor like 2	Homo sapiens	88-91
23007914-3	2013	To determine how ginsenosides prevent hair loss, we topically applied protopanaxadiol-type ginsenosides Rb1 and Rd over the shaved skin of B57CL/6 mice, and monitored and assessed them for 35 days.	protopanaxadiol	70-85	RB transcriptional corepressor 1	Mus musculus	104-107
22907191-0	2013	20(S)-protopanaxadiol-aglycone downregulation of the full-length and splice variants of androgen receptor.	protopanaxadiol	2-21	androgen receptor	Homo sapiens	88-105
22864749-3	2012	To extend this study, we evaluated the protective effect of protopanaxadiol-type ginsenoside Rb1 (gRb1) on H(2)O(2)-induced oxidative injury in cardiomyocytes and explored the ROS-mediated intracellular signaling mechanism.	protopanaxadiol	60-75	RB transcriptional corepressor 1	Gallus gallus	93-96
23407364-1	2013	20(S)-protopanaxadiol (PPD) is an extract of Panax quinquefolius L. The aim of this study was to investigate the effect of PPD on the antitumor activity and toxicity of cyclophosphamide (CTX) in tumor-bearing mice.	protopanaxadiol	0-21	V-set and immunoglobulin domain containing 2	Mus musculus	187-190
23407364-1	2013	20(S)-protopanaxadiol (PPD) is an extract of Panax quinquefolius L. The aim of this study was to investigate the effect of PPD on the antitumor activity and toxicity of cyclophosphamide (CTX) in tumor-bearing mice.	protopanaxadiol	23-26	V-set and immunoglobulin domain containing 2	Mus musculus	187-190
23281928-0	2013	Paraptosis and NF-kappaB activation are associated with protopanaxadiol-induced cancer chemoprevention.	protopanaxadiol	56-71	nuclear factor kappa B subunit 1	Homo sapiens	15-24
24117074-0	2013	20(S)-protopanaxadiol triggers mitochondrial-mediated apoptosis in human lung adenocarcinoma A549 cells via inhibiting the PI3K/Akt signaling pathway.	protopanaxadiol	0-21	AKT serine/threonine kinase 1	Homo sapiens	128-131
24117074-8	2013	Furthermore, 20(S)-PPD also triggered down-regulation of phosphorylated Akt (Ser473/Thr308) and glycogen synthase kinase 3beta (GSK 3beta).	protopanaxadiol	15-22	AKT serine/threonine kinase 1	Homo sapiens	72-75
24117074-8	2013	Furthermore, 20(S)-PPD also triggered down-regulation of phosphorylated Akt (Ser473/Thr308) and glycogen synthase kinase 3beta (GSK 3beta).	protopanaxadiol	15-22	glycogen synthase kinase 3 beta	Homo sapiens	96-126
24117074-8	2013	Furthermore, 20(S)-PPD also triggered down-regulation of phosphorylated Akt (Ser473/Thr308) and glycogen synthase kinase 3beta (GSK 3beta).	protopanaxadiol	15-22	glycogen synthase kinase 3 beta	Homo sapiens	128-137
24117074-9	2013	Knockdown of GSK 3beta with siRNA promoted the apoptotic effects of 20(S)-PPD.	protopanaxadiol	70-77	glycogen synthase kinase 3 beta	Homo sapiens	13-22
22759348-7	2013	It was also found that GA coordinated with other anti-cancer drugs (such as adriamycin, docetaxel, verapamil and protopanaxadiol) to enhance cellular cytotoxicity on human epithelial cancer cell lines with higher ABCB1 expression levels.	protopanaxadiol	113-128	ATP binding cassette subfamily B member 1	Homo sapiens	213-218
22530069-6	2012	In vitro studies showed that Rh2 epimers and their corresponding deglycosylation metabolites protopanaxadiol (Ppd) epimers all exhibited stereoselective regulations of P-gp.	protopanaxadiol	93-108	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	168-172
22530069-7	2012	In conclusion, in view of the in vitro and in vivo dispositions of Rh2 and the regulations of P-gp by Rh2 and Ppd, it is suggested that the P-gp regulatory effect of Rh2 in vivo actually is a double actions of both Rh2 and Ppd, and the net effect is determined by the relative balance between Rh2 and Ppd with the same configuration.	protopanaxadiol	110-113	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	94-98
22530069-7	2012	In conclusion, in view of the in vitro and in vivo dispositions of Rh2 and the regulations of P-gp by Rh2 and Ppd, it is suggested that the P-gp regulatory effect of Rh2 in vivo actually is a double actions of both Rh2 and Ppd, and the net effect is determined by the relative balance between Rh2 and Ppd with the same configuration.	protopanaxadiol	110-113	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	140-144
21811908-5	2011	Therefore, Rb2 is the first protopanaxadiol-type ginsenoside shown to inhibit hepatic gluconeogenesis through AMPK activation.	protopanaxadiol	28-43	RB transcriptional corepressor like 2	Homo sapiens	11-14
15467194-3	2004	Utilizing the probe reaction of CYP3A activity, testosterone 6beta-hydroxylation, the effects of derivatives of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol families on CYP3A activity in rat liver microsomes were assayed.	protopanaxadiol	114-133	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	173-178
23717061-5	2011	In the present study, we examined the effects of ginsenoside metabolites such as compound K (CK), protopanaxadiol (PPD), and protopanaxatriol (PPT) on HERG K(+) channel activity by expressing human alpha subunits in Xenopus oocytes.	protopanaxadiol	98-113	potassium voltage-gated channel subfamily H member 2	Homo sapiens	151-155
21490677-1	2011	20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, which is reported to be pro-apoptotic in some cells but anti-apoptotic in neuronal cells by regulating Akt signaling.	protopanaxadiol	0-19	AKT serine/threonine kinase 1	Homo sapiens	167-170
20191356-0	2010	Effect of protopanaxadiol derivatives in high glucose-induced fibronectin expression in primary cultured rat mesangial cells: role of mitogen-activated protein kinases and Akt.	protopanaxadiol	10-25	fibronectin 1	Rattus norvegicus	62-73
19291609-0	2009	20S-protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.	protopanaxadiol	0-19	phosphoglycolate phosphatase	Mus musculus	29-43
18379076-2	2008	In our preliminary studies, protopanaxadiol ginsenosides showed the insulin secretion-stimulating activity.	protopanaxadiol	28-43	insulin	Mesocricetus auratus	68-75
17069940-0	2007	Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice.	protopanaxadiol	20-35	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	112-121
16700822-6	2006	Taken together, these results indicated that ginsenoside 20(S)-protopanaxadiol is able to inhibit the invasiveness of HT1080 cells significantly in vitro and this action may be primarily due to down-regulating the expression of matrix metalloproteinase-2.	protopanaxadiol	59-78	matrix metallopeptidase 2	Homo sapiens	228-254
16547074-5	2006	It is noteworthy that Compound K, protopanaxadiol (Ppd), and protopanaxatriol (Ppt) all exhibited moderate inhibition against CYP2C9 activity, and Ppd and Ppt also exhibited potent competitive inhibition against CYP3A4 activity.	protopanaxadiol	34-49	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	126-132
16547074-5	2006	It is noteworthy that Compound K, protopanaxadiol (Ppd), and protopanaxatriol (Ppt) all exhibited moderate inhibition against CYP2C9 activity, and Ppd and Ppt also exhibited potent competitive inhibition against CYP3A4 activity.	protopanaxadiol	34-49	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	212-218
16395656-0	2005	Anti-inflammatory activity of 20(S)-protopanaxadiol: enhanced heme oxygenase 1 expression in RAW 264.7 cells.	protopanaxadiol	30-51	heme oxygenase 1	Mus musculus	62-78
11824558-5	2002	metabolized ginsenoside Rg3 to protopanaxadiol via ginsenoside Rh2.	protopanaxadiol	31-46	Rh associated glycoprotein	Homo sapiens	63-66
12451485-9	2002	EGF:epidermal growth factor PD:protopanaxadiol PT:protopanaxatriol PTCs:primary cultured renal proximal tubule cells	protopanaxadiol	31-46	pro-epidermal growth factor	Oryctolagus cuniculus	0-3
11824558-8	2002	Among ginsenoside Rg3 and its metabolites, 20(S)-protopanaxadiol and 20(S)-ginsenoside Rh2 exhibited the most potent cytotoxicity against tumor cell lines, 20(S)- and 20(R)-protopanaxadiols potently inhibited the growth of Helicobacter pylori, and 20(S)-ginsenoside Rh2 inhibited H+/K+ ATPase of rat stomach.	protopanaxadiol	45-64	Rh associated glycoprotein	Homo sapiens	266-269
11345690-0	2001	In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists.	protopanaxadiol	30-45	tumor necrosis factor	Homo sapiens	62-95
11748374-6	2001	Several workers studied the metabolic transformation by human intestinal bacteria after oral administration of ginsenoside Rb-1 and Rb-2 and found that the stepwise deglyco-sylation yielded compound K and finally 20(S)-protopanaxadiol.	protopanaxadiol	215-234	RB transcriptional corepressor 1	Homo sapiens	123-136
11145182-1	2000	When ginsenoside Rb1 and Rb2 were anaerobically incubated with human intestinal microflora, these ginsenosides were metabolized to 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (compound K) and 20(S)-protopanaxadiol.	protopanaxadiol	160-179	RB transcriptional corepressor 1	Homo sapiens	17-20
11145182-1	2000	When ginsenoside Rb1 and Rb2 were anaerobically incubated with human intestinal microflora, these ginsenosides were metabolized to 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (compound K) and 20(S)-protopanaxadiol.	protopanaxadiol	160-179	RB transcriptional corepressor like 2	Homo sapiens	25-28
9933987-1	1998	The antimetastatic effects of orally administered ginsenoside Rb1 (Rb1) and an active metabolite by intestinal bacteria, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (I), were studied, by using a spontaneous metastasis model produced by subcutaneous injection of Lewis lung carcinoma (LLC) in syngeneic C57BL/6 mice.	protopanaxadiol	154-169	RB transcriptional corepressor 1	Mus musculus	62-65
9933987-1	1998	The antimetastatic effects of orally administered ginsenoside Rb1 (Rb1) and an active metabolite by intestinal bacteria, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (I), were studied, by using a spontaneous metastasis model produced by subcutaneous injection of Lewis lung carcinoma (LLC) in syngeneic C57BL/6 mice.	protopanaxadiol	154-169	RB transcriptional corepressor 1	Mus musculus	67-70
9848395-2	1998	This study aimed to assess the effects of ginsenoside, Rb1, which belongs to the protopanaxadiol, on the mechanism of mediator release during mast cell activation.	protopanaxadiol	81-96	LOW QUALITY PROTEIN: retinoblastoma-associated protein	Cavia porcellus	55-58
9643450-4	1998	These experiments were conducted to determine the effects of the ginsenosides Rb1 and Rg1, major components of the protopanaxadiol and protopanaxatriol fractions of ginseng saponin, on morphine-induced hyperactivity and conditioned place-preference.	protopanaxadiol	115-130	protein phosphatase 1, regulatory subunit 3A	Mus musculus	86-89