PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33733756-3 2021 Herein, we report irreversible inhibitors of the human double minute 2 (HDM2)/p53 PPI, which employ a reactive N-acyl-N-alkyl sulfonamide (NASA) group as a warhead. nasa 139-143 MDM2 proto-oncogene Homo sapiens 72-76 34413960-3 2021 To test this possibility, we developed a series of CDK2-targeting N-acyl-N-alkylsulfonamide (NASA)-containing acylation probes. nasa 93-97 cyclin dependent kinase 2 Homo sapiens 51-55 34413960-5 2021 We determined that upon target binding, NASA-mediated reaction resulted in selective functionalization of Lys89 on purified or native CDK2. nasa 40-44 cyclin dependent kinase 2 Homo sapiens 134-138 33733756-3 2021 Herein, we report irreversible inhibitors of the human double minute 2 (HDM2)/p53 PPI, which employ a reactive N-acyl-N-alkyl sulfonamide (NASA) group as a warhead. nasa 139-143 tumor protein p53 Homo sapiens 78-81