PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 12663510-4 2003 Se, in the form of sodium selenite, induced TrxR1 at the translational level, as shown by an increase in protein (2.1-fold) and activity (4.8-fold), but not mRNA. Sodium Selenite 19-34 thioredoxin reductase 1 Homo sapiens 44-49 12513738-0 2002 [Inhibition of the activation of transcriptional factor NFkappaB during sodium selenite-induced apoptosis in NB4 cells]. Sodium Selenite 72-87 nuclear factor kappa B subunit 1 Homo sapiens 56-64 12667344-5 2002 Sodium selenite at concentration of 2 micromol/L was not able to induce differentiation of NB4 cells, but when combined with 0.1 micromol/L ATRA, CD(11b) expression and NBT reduction were increased as compared with that of 0.1 micromol/L ATRA alone. Sodium Selenite 0-15 integrin subunit alpha M Homo sapiens 146-152 12628500-7 2003 Sodium selenite increased the activities of glutathione peroxidase and catalase. Sodium Selenite 0-15 catalase Cricetulus griseus 71-79 12160929-6 2002 Cotreatment of p53-WT H460 cells with free radical scavengers, such as D-mannitol, uric acid, and sodium selenite, significantly attenuated the TCE- or PERC-induced lipid peroxidation. Sodium Selenite 98-113 tumor protein p53 Homo sapiens 15-18 12513738-1 2002 In order to evaluate the effect of sodium selenite on the activation of NFkappaB during selenite-induced apoptosis in NB4 cells, Western blot was used to measure the level of P65 in nuclear extraction of NB4 cells treated with sodium selenite to reflect the activation of NFkappaB; the apoptosis of NB4 cells was determined by morphological observation, DNA ladder electrophoresis and flow cytometry; and MTT test was used to measure the growth inhibition of cells. Sodium Selenite 35-50 nuclear factor kappa B subunit 1 Homo sapiens 72-80 12513738-1 2002 In order to evaluate the effect of sodium selenite on the activation of NFkappaB during selenite-induced apoptosis in NB4 cells, Western blot was used to measure the level of P65 in nuclear extraction of NB4 cells treated with sodium selenite to reflect the activation of NFkappaB; the apoptosis of NB4 cells was determined by morphological observation, DNA ladder electrophoresis and flow cytometry; and MTT test was used to measure the growth inhibition of cells. Sodium Selenite 227-242 RELA proto-oncogene, NF-kB subunit Homo sapiens 175-178 12513738-2 2002 Results showed that sodium selenite (>/=5 micro mol/L) suppressed the cell growth, induced apoptosis and inhibited the activation of NF kappaB in a concentration- and time-dependency pattern. Sodium Selenite 20-35 nuclear factor kappa B subunit 1 Homo sapiens 136-145 12898900-5 2002 There was a statistically significant increase in the selenium contents in lungs after supplementation with selenosemicarbazide and sodium selenite (11.81 micrograms g-1 and 6.79 micrograms g-1 vs. 1.75 micrograms g-1 in controls). Sodium Selenite 132-147 allograft inflammatory factor 1 Mus musculus 166-175 12481431-6 2002 Sodium selenite and MeSeA, at the concentrations that induced apoptosis, inhibited NF-kappa B DNA binding induced by tumor necrosis factor-alpha and lipopolysaccharide in DU145 and JCA1 prostate cells. Sodium Selenite 0-15 nuclear factor kappa B subunit 1 Homo sapiens 83-93 12481431-6 2002 Sodium selenite and MeSeA, at the concentrations that induced apoptosis, inhibited NF-kappa B DNA binding induced by tumor necrosis factor-alpha and lipopolysaccharide in DU145 and JCA1 prostate cells. Sodium Selenite 0-15 tumor necrosis factor Homo sapiens 117-144 12481431-9 2002 We showed that sodium selenite and MSeA inhibited I kappa B kinase activation and I kappa B-alpha phosphorylation and degradation induced by TNF-alpha and lipopolysaccharide in prostate cells. Sodium Selenite 15-30 NFKB inhibitor alpha Homo sapiens 82-97 12481431-9 2002 We showed that sodium selenite and MSeA inhibited I kappa B kinase activation and I kappa B-alpha phosphorylation and degradation induced by TNF-alpha and lipopolysaccharide in prostate cells. Sodium Selenite 15-30 tumor necrosis factor Homo sapiens 141-150 10967555-2 2000 Treatment of cells with 1 uM of sodium selenite resulted in a 40% decrease in the amount of estrogen receptor-alpha and in a parallel decrease of 40% in ER-alpha mRNA. Sodium Selenite 32-47 estrogen receptor 1 Homo sapiens 92-115 11799919-4 2001 p-XSC and sodium selenite reduced the consensus site binding activity of NF-kappa B in a concentration-dependent manner when nuclear extracts from cells stimulated with tumor necrosis factor-alpha were incubated with either compound ("in vitro"). Sodium Selenite 10-25 nuclear factor kappa B subunit 1 Homo sapiens 73-83 11799919-4 2001 p-XSC and sodium selenite reduced the consensus site binding activity of NF-kappa B in a concentration-dependent manner when nuclear extracts from cells stimulated with tumor necrosis factor-alpha were incubated with either compound ("in vitro"). Sodium Selenite 10-25 tumor necrosis factor Homo sapiens 169-196 11799919-7 2001 p-XSC or sodium selenite reduced the consensus site binding of transcription factors Sp1 and Sp3 in concentration- and time-dependent manners when nuclear extracts from cells treated with either compound in vivo were assayed by electrophoretic mobility shift assay. Sodium Selenite 9-24 Sp3 transcription factor Homo sapiens 93-96 10967555-2 2000 Treatment of cells with 1 uM of sodium selenite resulted in a 40% decrease in the amount of estrogen receptor-alpha and in a parallel decrease of 40% in ER-alpha mRNA. Sodium Selenite 32-47 estrogen receptor 1 Homo sapiens 153-161 12212276-0 1999 [Free radicals on cataracts induced by sodium selenite studied by ESR and LPO]. Sodium Selenite 39-54 lactoperoxidase Rattus norvegicus 74-77 10781391-6 2000 Transient and acute changes in lymphocyte, granulocyte and platelet phospholipid-hydroperoxide glutathione peroxidase (GPx4) activity occurred by day 7 or 14 of sodium selenite treatment and by day 7 in lymphocytes from selenomethionine-treated subjects compared with controls taking a placebo. Sodium Selenite 161-176 glutathione peroxidase 4 Homo sapiens 68-117 10781391-6 2000 Transient and acute changes in lymphocyte, granulocyte and platelet phospholipid-hydroperoxide glutathione peroxidase (GPx4) activity occurred by day 7 or 14 of sodium selenite treatment and by day 7 in lymphocytes from selenomethionine-treated subjects compared with controls taking a placebo. Sodium Selenite 161-176 glutathione peroxidase 4 Homo sapiens 119-123 9535791-5 1998 Basal cellular glutathione peroxidase enzyme activity in hFOB-cells (19.7 nmol NADPH oxidised per min and microg protein) was further increased 2.5-fold by the addition of 100 nM sodium selenite to the culture medium for 3 days. Sodium Selenite 179-194 glutathione peroxidase 1 Homo sapiens 6-37 10344722-5 1999 RESULTS: Of 26 agents screened, BRCA1 and BRCA2 mRNA reductions were observed in both cell lines after exposure to adriamycin (ADR), camptothecin (CPT), sodium selenite (SLN), and ultraviolet radiation (UV), while nitrogen mustard (HN2) caused mRNA reduction in DU-145 but not in Tsu-Prl. Sodium Selenite 153-168 BRCA1 DNA repair associated Homo sapiens 32-37 10344722-5 1999 RESULTS: Of 26 agents screened, BRCA1 and BRCA2 mRNA reductions were observed in both cell lines after exposure to adriamycin (ADR), camptothecin (CPT), sodium selenite (SLN), and ultraviolet radiation (UV), while nitrogen mustard (HN2) caused mRNA reduction in DU-145 but not in Tsu-Prl. Sodium Selenite 153-168 BRCA2 DNA repair associated Homo sapiens 42-47 10333487-4 1999 TR activities in COS-1 cells expressing rat TR were increased in accordance with supplemented sodium selenite concentrations, whereas levels of TR protein, examined by Western blotting, were not affected by sodium selenite concentrations. Sodium Selenite 94-109 peroxiredoxin 5 Rattus norvegicus 0-2 10333487-4 1999 TR activities in COS-1 cells expressing rat TR were increased in accordance with supplemented sodium selenite concentrations, whereas levels of TR protein, examined by Western blotting, were not affected by sodium selenite concentrations. Sodium Selenite 94-109 peroxiredoxin 5 Rattus norvegicus 44-46 16801090-2 1999 It was shown that sodium selenite, after 30 min preincubation, inhibited platelet aggregation induced by 0.1 U/ml of thrombin and by 10 microM ADP (about 30% inhibition of aggregation after pretreatment of platelets with 10(-4) M of Se). Sodium Selenite 18-33 coagulation factor II, thrombin Homo sapiens 117-125 16801090-4 1999 Pretreatment of blood platelets with sodium selenite resulted in a statistically significant decrease in adenine nucleotide secretion ( P < 0.01) and release of malonyldialdehyde (MDA), produced in equal amounts to TXA(2) , in thrombin-stimulated platelets ( P <0.001). Sodium Selenite 37-52 coagulation factor II, thrombin Homo sapiens 230-238 10218497-6 1999 When cells were grown in a medium supplemented with sodium selenite (1 microM) for 48 h, complete protection was afforded against the activation of p38 and against nitration of tyrosine residues. Sodium Selenite 52-67 mitogen activated protein kinase 14 Rattus norvegicus 148-151 10682604-4 1998 The results indicated that both sodium selenite and selenomethionine inhibit the transmembrane movement of Ca2- and sodium selenite also inhibits transmembrane movement of K+. Sodium Selenite 32-47 carbonic anhydrase 2 Rattus norvegicus 107-110 8437984-2 1993 This study shows that dietary (2 ppm for 8 weeks) or in vitro (1 x 10(-7) M) supplementation with Se (as sodium selenite) results in a significant upregulation of the expression of both the p55 and p70/75 IL-2 binding sites on the surface of concanavalin A-stimulated lymphocytes from C57BL/6J mice. Sodium Selenite 105-120 tumor necrosis factor receptor superfamily, member 1a Mus musculus 190-193 9713361-8 1998 PUFA-induced apoptosis was oxidative, being blocked by both vitamin E acetate and sodium selenite, the latter in a critically time-dependent manner. Sodium Selenite 82-97 pumilio RNA binding family member 3 Homo sapiens 0-4 10682638-0 1998 [Effects of selenium polysaccharide and sodium selenite on blood selenium concentration and liver cytochrome P450 monooxygenase system in rat]. Sodium Selenite 40-55 cytochrome P450, family 2, subfamily j, polypeptide 3 Rattus norvegicus 98-127 9359853-11 1997 In ECVPHGPx+SelD+ under conditions of selenium restriction, IL-1 induced NF kappa B activation only to a similar extent as under conditions of selenium supplementation in controls, and activation was abolished with 50 nM sodium selenite. Sodium Selenite 221-236 selenophosphate synthetase 1 Homo sapiens 12-16 9359853-11 1997 In ECVPHGPx+SelD+ under conditions of selenium restriction, IL-1 induced NF kappa B activation only to a similar extent as under conditions of selenium supplementation in controls, and activation was abolished with 50 nM sodium selenite. Sodium Selenite 221-236 nuclear factor kappa B subunit 1 Homo sapiens 73-83 9116292-6 1997 Diamide and sodium selenite, which have been reported to inhibit ADF/thioredoxin, restored the sensitivity to ADM in ATL and ADM-resistant ATL cell lines. Sodium Selenite 12-27 thioredoxin Homo sapiens 65-68 9116292-6 1997 Diamide and sodium selenite, which have been reported to inhibit ADF/thioredoxin, restored the sensitivity to ADM in ATL and ADM-resistant ATL cell lines. Sodium Selenite 12-27 thioredoxin Homo sapiens 69-80 9148594-1 1996 In vitro influence of sodium selenite on cytochrome P-450-dependent formation of active oxygen species on lipid peroxidation (LPO) in rat liver microsomes was studied. Sodium Selenite 22-37 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 41-57 7905918-2 1994 In Experiment 1, liver and mammary tissue concentration of reduced glutathione (GSH) and activities of gamma-glutamylcysteine synthetase (GCS), glutathione reductase (GR) and glutathione S-transferases (GST) were positively correlated with tissue selenium concentration in female rats fed semipurified diets supplemented with sodium selenite (0.05 to 4 mg Se/kg). Sodium Selenite 326-341 glutamate-cysteine ligase, catalytic subunit Rattus norvegicus 103-136 9443604-8 1998 Furthermore, treating the PGHS-2-expressing cells with sodium selenite or ebselen, reducing agents of intracellular peroxides, only decreased PGHS-2 activity. Sodium Selenite 55-70 prostaglandin-endoperoxide synthase 2 Mus musculus 26-32 9443604-8 1998 Furthermore, treating the PGHS-2-expressing cells with sodium selenite or ebselen, reducing agents of intracellular peroxides, only decreased PGHS-2 activity. Sodium Selenite 55-70 prostaglandin-endoperoxide synthase 2 Mus musculus 142-148 9666318-6 1998 This transient response of TRR mRNA was not reflected at the TRR enzyme activity level upon treatment with 1,25(OH)2D3 for up to 48 h. Sodium selenite added to differentiated FOB cells increased TRR enzyme activity 2.6-fold, whereas no selenite effect on TRR mRNA steady state levels was measurable. Sodium Selenite 135-150 peroxiredoxin 5 Homo sapiens 27-30 9354464-6 1997 We have investigated mechanisms by which selenium, in the form of sodium selenite, added to serum-free growth medium regulates TR activity in cancer cell lines. Sodium Selenite 66-81 peroxiredoxin 5 Homo sapiens 127-129 9587653-1 1997 The aim of the present study was to examine the activity of nitric oxide synthase (NOS, EC 1.14.23) in plasma of high fat diet (HFD, 2% cholesterol and 100 g table butter/kg diet) and HFD + selenium (Se, 1 ppm as sodium selenite) fed rabbits for three months. Sodium Selenite 213-228 nitric oxide synthase, brain Oryctolagus cuniculus 60-81 9363997-7 1997 In addition, the level of selenophosphate synthetase mRNA (SelD), a key intermediate in tRNA(Sec) formation, increased 1.2- to 1.7-fold in A-427 and A-172 cells after pretreatment with sodium selenite. Sodium Selenite 185-200 selenophosphate synthetase 1 Homo sapiens 59-63 9413175-3 1997 Sodium selenite and other Se containing compounds produced a time and concentration dependent increase in intracellular thioredoxin reductase activity and protein levels. Sodium Selenite 0-15 peroxiredoxin 5 Homo sapiens 120-141 9407554-6 1997 The acute lethal toxicity of T-2 toxin (2.5 mg/kg) was reduced by administration of only sodium selenite (3 mg/kg) and cis-stilbene oxide (50 mg/kg). Sodium Selenite 89-104 brachyury 2 Mus musculus 29-32 8947525-2 1996 In the present study, sodium selenite was compared to methylselenocysteine (MSC) for their individual effects on cell growth, cdc2/cdk2 kinase activities and the levels of cyclins D1, E and A bound to cdk2 in a mouse mammary epithelial cell culture model. Sodium Selenite 22-37 cyclin-dependent kinase 1 Mus musculus 126-130 8947525-2 1996 In the present study, sodium selenite was compared to methylselenocysteine (MSC) for their individual effects on cell growth, cdc2/cdk2 kinase activities and the levels of cyclins D1, E and A bound to cdk2 in a mouse mammary epithelial cell culture model. Sodium Selenite 22-37 cyclin-dependent kinase 2 Mus musculus 131-135 8947525-2 1996 In the present study, sodium selenite was compared to methylselenocysteine (MSC) for their individual effects on cell growth, cdc2/cdk2 kinase activities and the levels of cyclins D1, E and A bound to cdk2 in a mouse mammary epithelial cell culture model. Sodium Selenite 22-37 cyclin-dependent kinase 2 Mus musculus 201-205 7876079-7 1995 Thioredoxin reductase modified by DNCB lacked reducing activity with oxidized thioredoxin, 5,5"-dithiobis-(2-nitrobenzoic acid), or sodium selenite. Sodium Selenite 132-147 peroxiredoxin 5 Homo sapiens 0-21 7946898-4 1994 This study shows that dietary supplementation of Se-replete humans with 200 micrograms/d of sodium selenite for 8 wk, or in vitro supplementation with 1 x 10(-7) M Se (as sodium selenite), result in a significant augmentation of the ability of peripheral blood lymphocytes to respond to stimulation with 1 microgram/mL of phytohemagglutinin or alloantigen (mixed lymphocyte reaction) and to express high affinity Il2-R on their surface. Sodium Selenite 92-107 interleukin 2 receptor subunit alpha Homo sapiens 413-418 7946898-4 1994 This study shows that dietary supplementation of Se-replete humans with 200 micrograms/d of sodium selenite for 8 wk, or in vitro supplementation with 1 x 10(-7) M Se (as sodium selenite), result in a significant augmentation of the ability of peripheral blood lymphocytes to respond to stimulation with 1 microgram/mL of phytohemagglutinin or alloantigen (mixed lymphocyte reaction) and to express high affinity Il2-R on their surface. Sodium Selenite 171-186 interleukin 2 receptor subunit alpha Homo sapiens 413-418 8437984-2 1993 This study shows that dietary (2 ppm for 8 weeks) or in vitro (1 x 10(-7) M) supplementation with Se (as sodium selenite) results in a significant upregulation of the expression of both the p55 and p70/75 IL-2 binding sites on the surface of concanavalin A-stimulated lymphocytes from C57BL/6J mice. Sodium Selenite 105-120 interleukin 2 receptor, beta chain Mus musculus 198-209 2105964-6 1990 c-fos transfected cells also had a faster growth rate than did control cells in serum-free medium supplemented with calcium chloride, lithium chloride, sodium selenite, hydrocortisone, and insulin. Sodium Selenite 152-167 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 1321713-2 1992 We have discovered that sodium selenite is a substrate for the thioredoxin system; 10 microM selenite plus 0.05 microM calf thymus thioredoxin reductase at pH 7.5 caused a non-stoichiometric oxidation of NADPH (100 microM after 30 min). Sodium Selenite 24-39 thioredoxin Bos taurus 63-74 1321713-2 1992 We have discovered that sodium selenite is a substrate for the thioredoxin system; 10 microM selenite plus 0.05 microM calf thymus thioredoxin reductase at pH 7.5 caused a non-stoichiometric oxidation of NADPH (100 microM after 30 min). Sodium Selenite 24-39 thioredoxin Bos taurus 131-142 1665866-3 1991 In a basal medium consisting of 75% DMEM, 25% Ham"s F-12, 5 nM sodium selenite, 50 microM 2-amino ethanol, and 2 mM histidine, supplemented with 5% FBS, we showed that aFGF, bFGF, and PDGF were all capable of stimulating Schwann cell growth and the stimulation was greatly potentiated by forskolin and dibutyryl-cAMP. Sodium Selenite 63-78 fibroblast growth factor 1 Rattus norvegicus 168-172 1664222-4 1991 SW1222 and HT29 cells required transferrin for growth, which was improved by other growth-promoting factors including epidermal growth factor (SW1222) and sodium selenite (HT29). Sodium Selenite 155-170 transferrin Homo sapiens 31-42 1645468-9 1991 The colonic mucosal ornithine decarboxylase activity was significantly inhibited by the administration of all three compounds, BSC (78%), BTC (62%), and sodium selenite (44%). Sodium Selenite 153-168 ornithine decarboxylase 1 Rattus norvegicus 20-43 8346073-10 1993 Attempts to reverse VES"s antiproliferative effects by addition of exogenous interleukin-2 or addition of sodium selenite, an enhancer of interleukin-2 receptors, failed. Sodium Selenite 106-121 interleukin 15 Gallus gallus 138-151 1577742-9 1992 For oxidative folding of reduced RNase in air with Trx, P34H Trx, or PDI, catalytic amounts of sodium selenite (1 microM) resulted in rapid disulfide formation and high yields of ribonuclease activity equivalent to previously known redox buffers of GSH and GSSG. Sodium Selenite 95-110 thioredoxin Bos taurus 51-54 1577742-9 1992 For oxidative folding of reduced RNase in air with Trx, P34H Trx, or PDI, catalytic amounts of sodium selenite (1 microM) resulted in rapid disulfide formation and high yields of ribonuclease activity equivalent to previously known redox buffers of GSH and GSSG. Sodium Selenite 95-110 thioredoxin Bos taurus 61-64 1577742-9 1992 For oxidative folding of reduced RNase in air with Trx, P34H Trx, or PDI, catalytic amounts of sodium selenite (1 microM) resulted in rapid disulfide formation and high yields of ribonuclease activity equivalent to previously known redox buffers of GSH and GSSG. Sodium Selenite 95-110 prolyl 4-hydroxylase subunit beta Bos taurus 69-72 1652384-2 1991 The results of rocket immunoelectrophoresis tests for the activated fragments C3d and C4d show that sodium selenite inhibits complement activation through the alternative pathway. Sodium Selenite 100-115 endogenous retrovirus group K member 13 Homo sapiens 78-81 20136422-4 2010 RESULTS: Intraperitoneal injection of sodium selenite (15 microM/kg body wt) to 8-10-day-old rat pups led to severe oxidative stress in eye lens as evidenced by enhanced LPO levels that led to cataract formation. Sodium Selenite 38-53 lactoperoxidase Rattus norvegicus 170-173 33779112-12 2021 miR-144 values were increased in the hyperthyroid group and the hyperthyroid group fed with 0.5 mg/kg sodium selenite compared to the control group (P<0.001, and P<0.05 respectively). Sodium Selenite 102-117 microRNA 144 Rattus norvegicus 0-7 20136422-5 2010 Sodium selenite also led to decrease in activities of SOD, GST, GPx, CAT with simultaneous decrease in the levels of GSH, vitamin C, and vitamin E. Sodium Selenite 0-15 catalase Rattus norvegicus 69-72 35486317-4 2022 The percentages of CD4+CD25+Foxp3+, CD4+CD25+, and CD4+CTLA-4+ cells in CD4+ T cells cultures stimulated with IL-2 and TGF-beta in the presence or absence of selenium, in the form of sodium selenite (2.0x10-6M), were evaluated by flow cytometry. Sodium Selenite 183-198 CD4 molecule Homo sapiens 19-22 34769040-0 2021 Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice. Sodium Selenite 41-56 apolipoprotein E Mus musculus 159-175 34461318-5 2021 Selenomethionine was superior to SS in activating the Nrf2 pathway and reducing the apoptosis rate of duodenum. Sodium Selenite 33-35 nuclear factor, erythroid 2 like 2 Gallus gallus 54-58 34201986-4 2021 The molecular mechanisms of the antitumor effect of sodium selenite alone involved apoptosis-inducing factor (AIF) and the expression of phospho-p38 in the combined therapy. Sodium Selenite 52-67 apoptosis-inducing factor, mitochondrion-associated 1 Mus musculus 83-108 34201986-4 2021 The molecular mechanisms of the antitumor effect of sodium selenite alone involved apoptosis-inducing factor (AIF) and the expression of phospho-p38 in the combined therapy. Sodium Selenite 52-67 apoptosis-inducing factor, mitochondrion-associated 1 Mus musculus 110-113 34201986-4 2021 The molecular mechanisms of the antitumor effect of sodium selenite alone involved apoptosis-inducing factor (AIF) and the expression of phospho-p38 in the combined therapy. Sodium Selenite 52-67 mitogen-activated protein kinase 14 Mus musculus 145-148 34094961-9 2021 Our data demonstrated that sodium selenite exhibits strong anticancer effects against thyroid cancer cells, which involved ROS-mediated inhibition of the AKT/mTOR pathway. Sodium Selenite 27-42 AKT serine/threonine kinase 1 Homo sapiens 154-157 34094961-9 2021 Our data demonstrated that sodium selenite exhibits strong anticancer effects against thyroid cancer cells, which involved ROS-mediated inhibition of the AKT/mTOR pathway. Sodium Selenite 27-42 mechanistic target of rapamycin kinase Homo sapiens 158-162 35513732-6 2022 However, sodium selenite attenuates these adverse effects, including increases in apoptotic rate, caspase 3 activity, MDA, GRP78, and CHOP expression and decreases in SELS expression in cells treated with ZEL or Thapsigargin (Tg, an ER stress agonist). Sodium Selenite 9-24 caspase 3 Homo sapiens 98-107 35513732-6 2022 However, sodium selenite attenuates these adverse effects, including increases in apoptotic rate, caspase 3 activity, MDA, GRP78, and CHOP expression and decreases in SELS expression in cells treated with ZEL or Thapsigargin (Tg, an ER stress agonist). Sodium Selenite 9-24 heat shock protein family A (Hsp70) member 5 Homo sapiens 123-128 35513732-6 2022 However, sodium selenite attenuates these adverse effects, including increases in apoptotic rate, caspase 3 activity, MDA, GRP78, and CHOP expression and decreases in SELS expression in cells treated with ZEL or Thapsigargin (Tg, an ER stress agonist). Sodium Selenite 9-24 DNA damage inducible transcript 3 Homo sapiens 134-138 35513732-6 2022 However, sodium selenite attenuates these adverse effects, including increases in apoptotic rate, caspase 3 activity, MDA, GRP78, and CHOP expression and decreases in SELS expression in cells treated with ZEL or Thapsigargin (Tg, an ER stress agonist). Sodium Selenite 9-24 selenoprotein S Homo sapiens 167-171 34970773-4 2022 Treatment with 0.5-muM sodium selenite (NaSe) or 5.0-muM selenomethionine (SeMet) significantly improved the proliferation rate and GPX4 protein expression after selenium deficiency. Sodium Selenite 23-38 glutathione peroxidase 4 Homo sapiens 132-136 34277562-1 2021 Herein, selenium and nitrogen co-doped carbon quantum dots (Se/N-CQDs) were hydrothermally synthesized by using citric acid, histidine, and sodium selenite, which had sp3 and sp2 hybridized carbon atoms and showed excitation-dependent fluorescence behavior. Sodium Selenite 140-155 Sp3 transcription factor Homo sapiens 167-170 34277562-1 2021 Herein, selenium and nitrogen co-doped carbon quantum dots (Se/N-CQDs) were hydrothermally synthesized by using citric acid, histidine, and sodium selenite, which had sp3 and sp2 hybridized carbon atoms and showed excitation-dependent fluorescence behavior. Sodium Selenite 140-155 Sp2 transcription factor Homo sapiens 175-178 35486317-4 2022 The percentages of CD4+CD25+Foxp3+, CD4+CD25+, and CD4+CTLA-4+ cells in CD4+ T cells cultures stimulated with IL-2 and TGF-beta in the presence or absence of selenium, in the form of sodium selenite (2.0x10-6M), were evaluated by flow cytometry. Sodium Selenite 183-198 CD4 molecule Homo sapiens 72-75 35263537-0 2022 Sodium Selenite Modulates IDO1/Kynurenine, TLR4, NF-kappaB and Bcl2/Bax : Pathway and Mitigates Acetic Acid-Induced Colitis in Rat. Sodium Selenite 0-15 indoleamine 2,3-dioxygenase 1 Rattus norvegicus 26-30 35263537-0 2022 Sodium Selenite Modulates IDO1/Kynurenine, TLR4, NF-kappaB and Bcl2/Bax : Pathway and Mitigates Acetic Acid-Induced Colitis in Rat. Sodium Selenite 0-15 toll-like receptor 4 Rattus norvegicus 43-47 35263537-0 2022 Sodium Selenite Modulates IDO1/Kynurenine, TLR4, NF-kappaB and Bcl2/Bax : Pathway and Mitigates Acetic Acid-Induced Colitis in Rat. Sodium Selenite 0-15 BCL2, apoptosis regulator Rattus norvegicus 63-67 35263537-0 2022 Sodium Selenite Modulates IDO1/Kynurenine, TLR4, NF-kappaB and Bcl2/Bax : Pathway and Mitigates Acetic Acid-Induced Colitis in Rat. Sodium Selenite 0-15 BCL2 associated X, apoptosis regulator Rattus norvegicus 68-71 35263537-9 2022 Sodium selenite markedly reduced tissue levels of malondialdehyde (MDA), TNF-alpha and interferon gamma (INF-gamma) and decreased myeloperoxidase (MPO) activity. Sodium Selenite 0-15 tumor necrosis factor Rattus norvegicus 73-82 35263537-9 2022 Sodium selenite markedly reduced tissue levels of malondialdehyde (MDA), TNF-alpha and interferon gamma (INF-gamma) and decreased myeloperoxidase (MPO) activity. Sodium Selenite 0-15 interferon gamma Rattus norvegicus 87-114 35263537-9 2022 Sodium selenite markedly reduced tissue levels of malondialdehyde (MDA), TNF-alpha and interferon gamma (INF-gamma) and decreased myeloperoxidase (MPO) activity. Sodium Selenite 0-15 myeloperoxidase Rattus norvegicus 130-145 35263537-9 2022 Sodium selenite markedly reduced tissue levels of malondialdehyde (MDA), TNF-alpha and interferon gamma (INF-gamma) and decreased myeloperoxidase (MPO) activity. Sodium Selenite 0-15 myeloperoxidase Rattus norvegicus 147-150 35263537-10 2022 Treatment with sodium selenite also significantly downregulated IL17, IL22, indoleamine 2,3-dioxygenase (IDO1), and kynurenine levels. Sodium Selenite 15-30 interleukin 17A Rattus norvegicus 64-68 35263537-10 2022 Treatment with sodium selenite also significantly downregulated IL17, IL22, indoleamine 2,3-dioxygenase (IDO1), and kynurenine levels. Sodium Selenite 15-30 interleukin 22 Rattus norvegicus 70-74 35263537-10 2022 Treatment with sodium selenite also significantly downregulated IL17, IL22, indoleamine 2,3-dioxygenase (IDO1), and kynurenine levels. Sodium Selenite 15-30 indoleamine 2,3-dioxygenase 1 Rattus norvegicus 105-109 35263537-11 2022 Western blotting revealed that sodium selenite prevented apoptosis by increasing bcl2/Bax ratio. Sodium Selenite 31-46 BCL2, apoptosis regulator Rattus norvegicus 81-85 35263537-11 2022 Western blotting revealed that sodium selenite prevented apoptosis by increasing bcl2/Bax ratio. Sodium Selenite 31-46 BCL2 associated X, apoptosis regulator Rattus norvegicus 86-89 35263537-12 2022 Furthermore, our findings showed that sodium selenite significantly downregulated the upstream inflammatory molecules such as nuclear factor kappa B (NF-kappaB) and toll-like receptor 4 (TLR4) in colitis. Sodium Selenite 38-53 toll-like receptor 4 Rattus norvegicus 165-185 35263537-12 2022 Furthermore, our findings showed that sodium selenite significantly downregulated the upstream inflammatory molecules such as nuclear factor kappa B (NF-kappaB) and toll-like receptor 4 (TLR4) in colitis. Sodium Selenite 38-53 toll-like receptor 4 Rattus norvegicus 187-191 2901147-2 1988 Pretreatment of male, Sprague-Dawley rats with sodium selenite (12.5 mumol Se/kg, ip) 24 hr prior to acetaminophen administration produced a significant protection against the hepatotoxic effects of acetaminophen as assessed by a decrease in the plasma appearance of alanine aminotransferase and aspartate aminotransferase activities following acetaminophen. Sodium Selenite 47-62 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 296-322 2583532-5 1989 It is suggested that SS acts by strengthening the antioxidative enzymes, namely catalase and peroxidase. Sodium Selenite 21-23 peroxidase 24 Musa acuminata 93-103 35087566-9 2021 Based on the CTD database, PPARG, ADAM12, IL6, SMAD3, and TIMP2 were identified to interact with selenium, sodium selenite, and T-2 toxin. Sodium Selenite 107-122 peroxisome proliferator activated receptor gamma Homo sapiens 27-32 35087566-9 2021 Based on the CTD database, PPARG, ADAM12, IL6, SMAD3, and TIMP2 were identified to interact with selenium, sodium selenite, and T-2 toxin. Sodium Selenite 107-122 ADAM metallopeptidase domain 12 Homo sapiens 34-40 35087566-9 2021 Based on the CTD database, PPARG, ADAM12, IL6, SMAD3, and TIMP2 were identified to interact with selenium, sodium selenite, and T-2 toxin. Sodium Selenite 107-122 interleukin 6 Homo sapiens 42-45 35087566-9 2021 Based on the CTD database, PPARG, ADAM12, IL6, SMAD3, and TIMP2 were identified to interact with selenium, sodium selenite, and T-2 toxin. Sodium Selenite 107-122 SMAD family member 3 Homo sapiens 47-52 35087566-9 2021 Based on the CTD database, PPARG, ADAM12, IL6, SMAD3, and TIMP2 were identified to interact with selenium, sodium selenite, and T-2 toxin. Sodium Selenite 107-122 TIMP metallopeptidase inhibitor 2 Homo sapiens 58-63 3507263-3 1987 Loss of both methionine sulfur incorporation and cystathionase activity occurred in transferrin/sodium selenite-supplemented Williams Medium E (TS-HWME) with a t 1/2 of about 96 hr through 72 hr in culture. Sodium Selenite 96-111 transferrin Rattus norvegicus 84-95 3286127-1 1988 Experimental nuclear cataract produced by an overdose of sodium selenite exhibited limited proteolysis, including breakdown of main intrinsic polypeptide (MIP26) to 24 and 22 kD fragments. Sodium Selenite 57-72 major intrinsic protein of lens fiber Homo sapiens 155-160 16665963-1 1988 Culture of the green alga Chlamydomonas reinhardtii in the medium containing sodium selenite caused the activity of ascorbate peroxidase to disappear and the appearance of glutathione peroxidase. Sodium Selenite 77-92 uncharacterized protein Chlamydomonas reinhardtii 172-194 3341044-0 1988 Growth in young rats after termination of sodium selenite exposure: studies of growth hormone and somatomedin C. In a previous study we have shown that the growth retarding effect of selenium in infant rats occurs concomitantly with severely reduced growth hormone responses and serum somatomedin C. Furthermore, normal growth may be restored by administration of exogenous growth hormone administration. Sodium Selenite 42-57 gonadotropin releasing hormone receptor Rattus norvegicus 250-264 3341044-0 1988 Growth in young rats after termination of sodium selenite exposure: studies of growth hormone and somatomedin C. In a previous study we have shown that the growth retarding effect of selenium in infant rats occurs concomitantly with severely reduced growth hormone responses and serum somatomedin C. Furthermore, normal growth may be restored by administration of exogenous growth hormone administration. Sodium Selenite 42-57 gonadotropin releasing hormone receptor Rattus norvegicus 250-264 3085347-3 1986 Diets poor in protein supplemented with sodium selenite and alpha-tocopherol acetate induced a significant increase in the selenium concentration and intensified the hepatic glutathione peroxidase and glutathione reductase activity. Sodium Selenite 40-55 glutathione-disulfide reductase Rattus norvegicus 201-222 3622906-2 1987 When injected i.p., sodium selenite promoted a marked increase of rat liver ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) activities; when administered with the diet for 6 weeks, a less marked increase in liver ODC was observed, whereas SAMDC was not significantly changed. Sodium Selenite 20-35 ornithine decarboxylase 1 Rattus norvegicus 76-99 3622906-2 1987 When injected i.p., sodium selenite promoted a marked increase of rat liver ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) activities; when administered with the diet for 6 weeks, a less marked increase in liver ODC was observed, whereas SAMDC was not significantly changed. Sodium Selenite 20-35 ornithine decarboxylase 1 Rattus norvegicus 101-104 3622906-2 1987 When injected i.p., sodium selenite promoted a marked increase of rat liver ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) activities; when administered with the diet for 6 weeks, a less marked increase in liver ODC was observed, whereas SAMDC was not significantly changed. Sodium Selenite 20-35 adenosylmethionine decarboxylase 1 Rattus norvegicus 110-144 3622906-2 1987 When injected i.p., sodium selenite promoted a marked increase of rat liver ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) activities; when administered with the diet for 6 weeks, a less marked increase in liver ODC was observed, whereas SAMDC was not significantly changed. Sodium Selenite 20-35 adenosylmethionine decarboxylase 1 Rattus norvegicus 146-151 3622906-2 1987 When injected i.p., sodium selenite promoted a marked increase of rat liver ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) activities; when administered with the diet for 6 weeks, a less marked increase in liver ODC was observed, whereas SAMDC was not significantly changed. Sodium Selenite 20-35 ornithine decarboxylase 1 Rattus norvegicus 242-245 3622906-2 1987 When injected i.p., sodium selenite promoted a marked increase of rat liver ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) activities; when administered with the diet for 6 weeks, a less marked increase in liver ODC was observed, whereas SAMDC was not significantly changed. Sodium Selenite 20-35 adenosylmethionine decarboxylase 1 Rattus norvegicus 268-273 3267460-4 1986 Intracellular GSH levels continued to increase in transferrin/sodium selenite-supplemented cultures, from 32 to 41.6 nmol/micrograms DNA, while GSH levels in unsupplemented cultures declined to 18 nmol/micrograms DNA. Sodium Selenite 62-77 transferrin Rattus norvegicus 50-61 24258016-4 1985 When more than an equimolar dose of sodium selenite was injected ip simultaneously with stannous chloride, the ALAD activity was completely retained. Sodium Selenite 36-51 aminolevulinate, delta-, dehydratase Mus musculus 111-115 7376275-4 1980 Administration of alpha-tocopherol and sodium selenite to animals with the burn disease inhibits lipids peroxidation, favours the retaining of the ascorbic acid content in the liver tissue, prevents a compensatory increase in the glucose-6-phosphate dehydrogenase activity and a rise in the level of reduced glutathione. Sodium Selenite 39-54 glucose-6-phosphate 1-dehydrogenase Cavia porcellus 230-263 7054467-3 1982 The decreased liver activity of GSH-Px could be partially corrected by daily supplementation of the basal diet with sodium selenite. Sodium Selenite 116-131 glutathione peroxidase 1 Rattus norvegicus 32-38 6531938-2 1984 Sodium selenite inhibited AHH activity to a maximum of approximately 70%. Sodium Selenite 0-15 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 26-29 6523806-5 1984 The use of combined vitamin E and sodium selenite prevered the toxic action of CCl4 on the liver in autumn, winter and spring and minimized it in summer. Sodium Selenite 34-49 C-C motif chemokine ligand 4 Rattus norvegicus 79-83 539449-1 1979 Prophylactically applied sodium selenite lowers blood pressure of rats with renal hypertension and suppresses rise in blood pressure following infusion of angiotensin II, and it diminishes the epinephrine toxicity by half. Sodium Selenite 25-40 angiotensinogen Rattus norvegicus 155-169 941315-0 1976 [Glutathione peroxidase and glutathione reductase activity in the rat liver after the administration of sodium selenite]. Sodium Selenite 104-119 glutathione-disulfide reductase Rattus norvegicus 28-49 941315-1 1976 Sodium selenite 24h after its single administration to rats causes an increase in the activity of glutathione peroxidase and glutathione reductase in the liver tissue. Sodium Selenite 0-15 glutathione-disulfide reductase Rattus norvegicus 125-146 1203259-0 1975 Elongation factor 2 as the target of the reaction product between sodium selenite and glutathione (GSSeSG) in the inhibiting of amino acid incorporation in vitro. Sodium Selenite 66-81 eukaryotic translation elongation factor 2 Rattus norvegicus 0-19 33495943-7 2021 Among hepatocytic differentiation-inducing factors, dexamethasone (DEX) and insulin-transferrin-sodium selenite (ITS) seemed to be involved in elevation of expression of CYP3A4 mRNA. Sodium Selenite 96-111 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 170-176 34041261-5 2021 We report here that, by 10 weeks of age, female Selenop/Scly double knockout (DKO) mice supplemented with 1 mg/ml sodium selenite in drinking water develop signs of hyper-adiposity not seen in male DKO mice. Sodium Selenite 114-129 selenoprotein P Mus musculus 48-55 34041261-5 2021 We report here that, by 10 weeks of age, female Selenop/Scly double knockout (DKO) mice supplemented with 1 mg/ml sodium selenite in drinking water develop signs of hyper-adiposity not seen in male DKO mice. Sodium Selenite 114-129 selenocysteine lyase Mus musculus 56-60 33866531-2 2021 In a phase I study (NCT02184533) in 15 subjects with metastatic cancer receiving daily oral sodium selenite with palliative radiation therapy, disease stabilization was observed, as evidenced by tumor regression, marked reduction in pain symptoms, and decreased prostate-specific antigen levels (only patients with castrate-resistant prostate cancer). Sodium Selenite 92-107 kallikrein related peptidase 3 Homo sapiens 262-287 34012523-1 2021 Background: The aim of the present study was to investigate the effect of Sodium Selenite (SS) supplemented media on oocyte maturation, expression of mitochondrial transcription factor A (TFAM) and embryo quality. Sodium Selenite 74-89 transcription factor A, mitochondrial Mus musculus 188-192 34012523-1 2021 Background: The aim of the present study was to investigate the effect of Sodium Selenite (SS) supplemented media on oocyte maturation, expression of mitochondrial transcription factor A (TFAM) and embryo quality. Sodium Selenite 91-93 transcription factor A, mitochondrial Mus musculus 188-192 34012523-10 2021 Conclusion: Supplementation of oocyte maturation culture media with SS improved the development rate of oocytes and embryo and also enhanced TFAM expression in MII oocytes which can affect the mitochondrial biogenesis of oocytes. Sodium Selenite 68-70 transcription factor A, mitochondrial Mus musculus 141-145 30218457-0 2019 Sodium selenite induces apoptosis via ROS-mediated NF-kappaB signaling and activation of the Bax-caspase-9-caspase-3 axis in 4T1 cells. Sodium Selenite 0-15 BCL2-associated X protein Mus musculus 93-96 33158753-7 2021 When sodium selenite was supplied into the culture medium, the amount of GPI-anchored LIPA and GALA was increased. Sodium Selenite 5-20 galactosidase alpha Homo sapiens 95-99 32634766-0 2020 Cytotoxicity of sodium selenite in HaCaT cells induces cell death and alters the mRNA expression of PUMA, ATR, and mTOR genes. Sodium Selenite 16-31 BCL2 binding component 3 Homo sapiens 100-104 32634766-0 2020 Cytotoxicity of sodium selenite in HaCaT cells induces cell death and alters the mRNA expression of PUMA, ATR, and mTOR genes. Sodium Selenite 16-31 ATR serine/threonine kinase Homo sapiens 106-109 32634766-0 2020 Cytotoxicity of sodium selenite in HaCaT cells induces cell death and alters the mRNA expression of PUMA, ATR, and mTOR genes. Sodium Selenite 16-31 mechanistic target of rapamycin kinase Homo sapiens 115-119 32236643-2 2020 The dose of sodium selenite was incorrectly indicated as 100 muM in the published version of "Selenium enhances TRPA1 channel-mediated activity of temozolomide in SH-SY5Y neuroblastoma cells". Sodium Selenite 12-27 latexin Homo sapiens 61-64 32236643-2 2020 The dose of sodium selenite was incorrectly indicated as 100 muM in the published version of "Selenium enhances TRPA1 channel-mediated activity of temozolomide in SH-SY5Y neuroblastoma cells". Sodium Selenite 12-27 transient receptor potential cation channel subfamily A member 1 Homo sapiens 112-117 33783357-6 2021 Indeed, we show that feeding mice a diet supplemented with sodium selenite results in an MR-like phenotype, marked by protection against diet-induced obesity, as well as altered plasma levels of IGF-1, FGF-21, adiponectin, and leptin. Sodium Selenite 59-74 insulin-like growth factor 1 Mus musculus 195-200 33783357-6 2021 Indeed, we show that feeding mice a diet supplemented with sodium selenite results in an MR-like phenotype, marked by protection against diet-induced obesity, as well as altered plasma levels of IGF-1, FGF-21, adiponectin, and leptin. Sodium Selenite 59-74 fibroblast growth factor 21 Mus musculus 202-208 33783357-6 2021 Indeed, we show that feeding mice a diet supplemented with sodium selenite results in an MR-like phenotype, marked by protection against diet-induced obesity, as well as altered plasma levels of IGF-1, FGF-21, adiponectin, and leptin. Sodium Selenite 59-74 adiponectin, C1Q and collagen domain containing Mus musculus 210-221 33783357-6 2021 Indeed, we show that feeding mice a diet supplemented with sodium selenite results in an MR-like phenotype, marked by protection against diet-induced obesity, as well as altered plasma levels of IGF-1, FGF-21, adiponectin, and leptin. Sodium Selenite 59-74 leptin Mus musculus 227-233 33684094-4 2021 Cells then either received no treatment (control group), or treatment with sodium selenite (Na2SeO3, Se), 3-morpholinosydnonimine (SIN1, which decomposes into peroxynitrite), or Se+SIN1. Sodium Selenite 75-90 squalene epoxidase Homo sapiens 95-97 33684094-4 2021 Cells then either received no treatment (control group), or treatment with sodium selenite (Na2SeO3, Se), 3-morpholinosydnonimine (SIN1, which decomposes into peroxynitrite), or Se+SIN1. Sodium Selenite 75-90 squalene epoxidase Homo sapiens 101-103 32040846-2 2020 Transient receptor potential vanilloid 1 (TRPV1) as a Ca2+ permeable cation channel is activated by capsaicin and reactive oxygen species (ROS), although it is blocked by capsazepine and sodium selenite (Na-Se). Sodium Selenite 187-202 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 32040846-2 2020 Transient receptor potential vanilloid 1 (TRPV1) as a Ca2+ permeable cation channel is activated by capsaicin and reactive oxygen species (ROS), although it is blocked by capsazepine and sodium selenite (Na-Se). Sodium Selenite 187-202 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 32905063-5 2020 Se-treated rats received 0.3 mg/l sodium selenite in drinking water. Sodium Selenite 34-49 squalene epoxidase Rattus norvegicus 0-2 32017928-0 2020 p53 controls the switch between autophagy and apoptosis through regulation of PLSCR1 in sodium selenite-treated leukemia cells. Sodium Selenite 88-103 tumor protein p53 Homo sapiens 0-3 32017928-0 2020 p53 controls the switch between autophagy and apoptosis through regulation of PLSCR1 in sodium selenite-treated leukemia cells. Sodium Selenite 88-103 phospholipid scramblase 1 Homo sapiens 78-84 32017928-4 2020 In this study, we showed that sodium selenite switched protective autophagy to apoptosis in p53-wild type NB4 cells without obvious caspase-8/apoptosis-inducing factor (AIF) axis activation, while induced autophagy-dependent caspase-8/AIF axis activation in p53-mutant Jurkat cells. Sodium Selenite 30-45 tumor protein p53 Homo sapiens 92-95 32017928-4 2020 In this study, we showed that sodium selenite switched protective autophagy to apoptosis in p53-wild type NB4 cells without obvious caspase-8/apoptosis-inducing factor (AIF) axis activation, while induced autophagy-dependent caspase-8/AIF axis activation in p53-mutant Jurkat cells. Sodium Selenite 30-45 apoptosis inducing factor mitochondria associated 1 Homo sapiens 132-167 32017928-4 2020 In this study, we showed that sodium selenite switched protective autophagy to apoptosis in p53-wild type NB4 cells without obvious caspase-8/apoptosis-inducing factor (AIF) axis activation, while induced autophagy-dependent caspase-8/AIF axis activation in p53-mutant Jurkat cells. Sodium Selenite 30-45 apoptosis inducing factor mitochondria associated 1 Homo sapiens 169-172 32017928-4 2020 In this study, we showed that sodium selenite switched protective autophagy to apoptosis in p53-wild type NB4 cells without obvious caspase-8/apoptosis-inducing factor (AIF) axis activation, while induced autophagy-dependent caspase-8/AIF axis activation in p53-mutant Jurkat cells. Sodium Selenite 30-45 caspase 8 Homo sapiens 132-141 32017928-4 2020 In this study, we showed that sodium selenite switched protective autophagy to apoptosis in p53-wild type NB4 cells without obvious caspase-8/apoptosis-inducing factor (AIF) axis activation, while induced autophagy-dependent caspase-8/AIF axis activation in p53-mutant Jurkat cells. Sodium Selenite 30-45 apoptosis inducing factor mitochondria associated 1 Homo sapiens 235-238 32017928-4 2020 In this study, we showed that sodium selenite switched protective autophagy to apoptosis in p53-wild type NB4 cells without obvious caspase-8/apoptosis-inducing factor (AIF) axis activation, while induced autophagy-dependent caspase-8/AIF axis activation in p53-mutant Jurkat cells. Sodium Selenite 30-45 tumor protein p53 Homo sapiens 258-261 32017928-6 2020 p53-dependent up-regulation of PLSCR1 accounted for the differential regulation of autophagy and apoptosis induced by sodium selenite. Sodium Selenite 118-133 tumor protein p53 Homo sapiens 0-3 32017928-6 2020 p53-dependent up-regulation of PLSCR1 accounted for the differential regulation of autophagy and apoptosis induced by sodium selenite. Sodium Selenite 118-133 phospholipid scramblase 1 Homo sapiens 31-37 32017928-7 2020 Furthermore, sodium selenite induced the release of AIF from mitochondria to cytosol with the facilitation of caspase-8 in Jurkat cells, while not in NB4 cells. Sodium Selenite 13-28 apoptosis inducing factor mitochondria associated 1 Homo sapiens 52-55 32017928-7 2020 Furthermore, sodium selenite induced the release of AIF from mitochondria to cytosol with the facilitation of caspase-8 in Jurkat cells, while not in NB4 cells. Sodium Selenite 13-28 caspase 8 Homo sapiens 110-119 32017928-9 2020 Our results indicate that PLSCR1 plays a critical role in p53-dependent regulation of autophagy and apoptosis in sodium selenite-treated leukemia cells. Sodium Selenite 113-128 phospholipid scramblase 1 Homo sapiens 26-32 32017928-9 2020 Our results indicate that PLSCR1 plays a critical role in p53-dependent regulation of autophagy and apoptosis in sodium selenite-treated leukemia cells. Sodium Selenite 113-128 tumor protein p53 Homo sapiens 58-61 32017928-10 2020 Manipulation of p53-PLSCR1 cascade might be beneficial to enhance the anti-tumor effects of sodium selenite. Sodium Selenite 92-107 tumor protein p53 Homo sapiens 16-19 32017928-10 2020 Manipulation of p53-PLSCR1 cascade might be beneficial to enhance the anti-tumor effects of sodium selenite. Sodium Selenite 92-107 phospholipid scramblase 1 Homo sapiens 20-26 32099356-13 2020 Treatment with sodium selenite for 7 days corrected the AgNP-caused alterations in morphological, ultrastructural, oxidative stress, caspase-3 activation and mitochondrial dynamic imbalance. Sodium Selenite 15-30 caspase 3 Rattus norvegicus 133-142 31610178-6 2020 However, MCD-fed mice treated with sodium selenite (a GPX4 activator) showed increase of hepatic GPX4, accompanied by reduced NASH severity. Sodium Selenite 35-50 glutathione peroxidase 4 Mus musculus 54-58 31610178-6 2020 However, MCD-fed mice treated with sodium selenite (a GPX4 activator) showed increase of hepatic GPX4, accompanied by reduced NASH severity. Sodium Selenite 35-50 glutathione peroxidase 4 Mus musculus 97-101 31882478-0 2020 Sodium Selenite Enhanced the Anti-proliferative Effect of MEK-ERK Inhibitor in Thyroid Cancer Cells. Sodium Selenite 0-15 mitogen-activated protein kinase kinase 7 Homo sapiens 58-61 31882478-0 2020 Sodium Selenite Enhanced the Anti-proliferative Effect of MEK-ERK Inhibitor in Thyroid Cancer Cells. Sodium Selenite 0-15 mitogen-activated protein kinase 1 Homo sapiens 62-65 31882478-8 2020 Decreased expression of p90RSK indicated that sodium selenite down-regulated ERK signaling in thyroid cancer cells. Sodium Selenite 46-61 ribosomal protein S6 kinase A1 Homo sapiens 24-30 31882478-8 2020 Decreased expression of p90RSK indicated that sodium selenite down-regulated ERK signaling in thyroid cancer cells. Sodium Selenite 46-61 mitogen-activated protein kinase 1 Homo sapiens 77-80 31882478-9 2020 CONCLUSION: The combination of U0126 and sodium selenite inhibited proliferation of thyroid cancer cells through ERK inhibition. Sodium Selenite 41-56 mitogen-activated protein kinase 1 Homo sapiens 113-116 31637977-5 2019 Compared with the HS group, SS and SeMet supplementation resulted in an increase (P < 0 05) in cell viability, decreased (P < 0 05) mRNA expression of HSP70 and six inflammation-related genes and rescue (P < 0 05) of mRNA and protein levels of CLDN-1 and ZO-1. Sodium Selenite 28-30 heat shock 70 kDa protein 6 Sus scrofa 157-162 31637977-5 2019 Compared with the HS group, SS and SeMet supplementation resulted in an increase (P < 0 05) in cell viability, decreased (P < 0 05) mRNA expression of HSP70 and six inflammation-related genes and rescue (P < 0 05) of mRNA and protein levels of CLDN-1 and ZO-1. Sodium Selenite 28-30 claudin 1 Sus scrofa 253-259 31637977-5 2019 Compared with the HS group, SS and SeMet supplementation resulted in an increase (P < 0 05) in cell viability, decreased (P < 0 05) mRNA expression of HSP70 and six inflammation-related genes and rescue (P < 0 05) of mRNA and protein levels of CLDN-1 and ZO-1. Sodium Selenite 28-30 zonula occludens 1 Sus scrofa 264-268 31768845-3 2019 In addition, the influence of two widely used antitumor selenium compounds (sodium selenite and methylseleninic acid) on the expression of SELM in cancer cells was studied. Sodium Selenite 76-91 selenoprotein M Homo sapiens 139-143 31768845-4 2019 On the basis of the results obtained by real-time PCR and Western blotting, we concluded that 1 muM and 10 muM sodium selenite did not affect the expression of SELM in fibrosarcoma cells, whereas in breast adenocarcinoma cells 1 muM sodium selenite slightly increased expression and 10 muM sodium selenite significantly (approximately 2 times) decreased it. Sodium Selenite 111-126 latexin Homo sapiens 107-110 31768845-4 2019 On the basis of the results obtained by real-time PCR and Western blotting, we concluded that 1 muM and 10 muM sodium selenite did not affect the expression of SELM in fibrosarcoma cells, whereas in breast adenocarcinoma cells 1 muM sodium selenite slightly increased expression and 10 muM sodium selenite significantly (approximately 2 times) decreased it. Sodium Selenite 111-126 latexin Homo sapiens 107-110 31768845-4 2019 On the basis of the results obtained by real-time PCR and Western blotting, we concluded that 1 muM and 10 muM sodium selenite did not affect the expression of SELM in fibrosarcoma cells, whereas in breast adenocarcinoma cells 1 muM sodium selenite slightly increased expression and 10 muM sodium selenite significantly (approximately 2 times) decreased it. Sodium Selenite 111-126 latexin Homo sapiens 107-110 31108386-0 2019 Combination of metformin with sodium selenite induces a functional phenotypic switch of human GM-CSF monocyte-derived macrophages. Sodium Selenite 30-45 colony stimulating factor 2 Homo sapiens 94-100 31168542-9 2019 Thus, by sensing the overall cellular redox conditions, mitochondrial Grx2 dimers become active monomers upon oxidative stress induced by sodium selenite with the consequent release of the iron-sulfur cluster, leading to activation of the intrinsic apoptotic pathway. Sodium Selenite 138-153 glutaredoxin 2 Homo sapiens 70-74 30944693-8 2019 We also explored whether selenium can antagonize the toxicity of DON in these two cell models and revealed the protective effect of sodium selenite on DON-induced cell damage in GPx1-overexpressing or knockdown splenic lymphocytes. Sodium Selenite 132-147 glutathione peroxidase 1 Cricetulus griseus 178-182 29546459-0 2018 Sodium selenite attenuates lung adenocarcinoma progression by repressing SOX2-mediated stemness. Sodium Selenite 0-15 SRY-box transcription factor 2 Homo sapiens 73-77 29897571-9 2018 However, supplementation with SS and Se-Met could improve ADG and FE, increase SelP and TP concentrations, elevate GSH-Px and TrxR1 activities, minimize the changes of oxidative stress and apoptosis parameters as well as ultrastructure of liver and kidney, whereas the effects of Se-Met were better than those of SS. Sodium Selenite 30-32 selenoprotein P Homo sapiens 79-83 29897571-9 2018 However, supplementation with SS and Se-Met could improve ADG and FE, increase SelP and TP concentrations, elevate GSH-Px and TrxR1 activities, minimize the changes of oxidative stress and apoptosis parameters as well as ultrastructure of liver and kidney, whereas the effects of Se-Met were better than those of SS. Sodium Selenite 30-32 thioredoxin reductase 1 Homo sapiens 126-131 30267989-0 2018 Sodium Selenite inhibits mitophagy, downregulation and mislocalization of blood-testis barrier proteins of bovine Sertoli cell exposed to microcystin-leucine arginine (MC-LR) via TLR4/NF-kB and mitochondrial signaling pathways blockage. Sodium Selenite 0-15 toll like receptor 4 Bos taurus 179-183 30583471-8 2018 SS was absorbed by R2J cells, was cytotoxic, induced an oxidative stress, and arrested cell growth in G2M before inducing both necrosis and apoptosis via caspase-3. Sodium Selenite 0-2 caspase 3 Homo sapiens 154-163 30518949-0 2018 Sodium selenite inhibits deoxynivalenol-induced injury in GPX1-knockdown porcine splenic lymphocytes in culture. Sodium Selenite 0-15 glutathione peroxidase 1 Cricetulus griseus 58-62 30153510-11 2018 Treatment of chondrocytes with sodium selenite resulted in reduced methylation and increased expression of GPX3 as well as down-regulated level of PI3K/Akt/c-fos proteins. Sodium Selenite 31-46 glutathione peroxidase 3 Homo sapiens 107-111 30153510-11 2018 Treatment of chondrocytes with sodium selenite resulted in reduced methylation and increased expression of GPX3 as well as down-regulated level of PI3K/Akt/c-fos proteins. Sodium Selenite 31-46 AKT serine/threonine kinase 1 Homo sapiens 152-155 30153510-11 2018 Treatment of chondrocytes with sodium selenite resulted in reduced methylation and increased expression of GPX3 as well as down-regulated level of PI3K/Akt/c-fos proteins. Sodium Selenite 31-46 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 156-161 28605550-11 2017 These results suggest pigeons supplemented with SS up-regulated GPx4, 1.0 mg of SS/kg exhibited superior reproductive performance, while 1.5 mg of SS/kg increased the selenium concentration, and 0.5 mg of SS/kg up-regulated GSH-Px activity. Sodium Selenite 48-50 glutathione peroxidase 4 Homo sapiens 64-68 29512717-2 2018 The results indicated that sodium selenite reduced cell viability and induced apoptosis by activating caspase-3 and members of the poly (ADP-ribose) polymerase and Bcl-2 protein families in SW982 cells. Sodium Selenite 27-42 caspase 3 Homo sapiens 102-111 29512717-2 2018 The results indicated that sodium selenite reduced cell viability and induced apoptosis by activating caspase-3 and members of the poly (ADP-ribose) polymerase and Bcl-2 protein families in SW982 cells. Sodium Selenite 27-42 poly(ADP-ribose) polymerase 1 Homo sapiens 131-159 29512717-2 2018 The results indicated that sodium selenite reduced cell viability and induced apoptosis by activating caspase-3 and members of the poly (ADP-ribose) polymerase and Bcl-2 protein families in SW982 cells. Sodium Selenite 27-42 BCL2 apoptosis regulator Homo sapiens 164-169 30221135-0 2018 The Ameliorating Effect of Sodium Selenite on the Histological Changes and Expression of Caspase-3 in the Testis of Monosodium Glutamate-Treated Rats: Light and Electron Microscopic Study. Sodium Selenite 27-42 caspase 3 Rattus norvegicus 89-98 29574326-5 2018 In this work, we studied the promoter activity of the Arabidopsis SBP genes, determined their tissue specificity and showed that they are differentially regulated by sodium selenite and sodium selenate. Sodium Selenite 166-181 selenium binding protein Arabidopsis thaliana 66-69 28965572-7 2017 SS induced a cell cycle arrest in the S phase and apoptosis via caspase-3. Sodium Selenite 0-2 caspase 3 Homo sapiens 64-73 28190183-7 2017 Further sodium selenite administration modulated the messenger RNA (mRNA) expression of GPx1, GPx2, and GPx4 in the spleen and intestine differentially and led to a significant increase in GPx activity (~1.5 to 2-folds) in these organs. Sodium Selenite 8-23 glutathione peroxidase 1 Mus musculus 88-92 28190183-7 2017 Further sodium selenite administration modulated the messenger RNA (mRNA) expression of GPx1, GPx2, and GPx4 in the spleen and intestine differentially and led to a significant increase in GPx activity (~1.5 to 2-folds) in these organs. Sodium Selenite 8-23 glutathione peroxidase 2 Mus musculus 94-98 28190183-7 2017 Further sodium selenite administration modulated the messenger RNA (mRNA) expression of GPx1, GPx2, and GPx4 in the spleen and intestine differentially and led to a significant increase in GPx activity (~1.5 to 2-folds) in these organs. Sodium Selenite 8-23 glutathione peroxidase 4 Mus musculus 104-108 28190183-7 2017 Further sodium selenite administration modulated the messenger RNA (mRNA) expression of GPx1, GPx2, and GPx4 in the spleen and intestine differentially and led to a significant increase in GPx activity (~1.5 to 2-folds) in these organs. Sodium Selenite 8-23 peroxiredoxin 6 pseudogene 2 Mus musculus 88-91 28123581-5 2017 To further investigate the effectiveness of selenium in radiotherapy, the present study examined the protective effects of sodium selenite supplementation administered prior to X-ray radiation treatment in CHEK-1 non-cancerous human esophageal cells. Sodium Selenite 123-138 checkpoint kinase 1 Homo sapiens 206-212 28254020-4 2017 Compared to untreated sprouts, total isoflavonoid, PAL activity and antioxidant capacity showed a remarkable increase of 83%, 56%, and 33%, respectively in chickpea sprouts that were treated with a high sodium selenite content (2mg/100g seeds). Sodium Selenite 203-218 phenylalanine ammonia-lyase 2 Cicer arietinum 51-54 28544404-6 2017 Sodium selenite could ameliorate hydrogen peroxide (H2 O2 )-induced cell apoptosis and improve expression levels of glutathione peroxidase and thioredoxin reductase. Sodium Selenite 0-15 peroxiredoxin 5 Rattus norvegicus 143-164 28544404-8 2017 Treatments with H2 O2 or sodium selenite decreased miR-328 levels. Sodium Selenite 25-40 microRNA 328 Rattus norvegicus 51-58 28544404-10 2017 MiR-328 might be involved in the effect of sodium selenite on H2 O2 -induced cell death in H9c2 cells. Sodium Selenite 43-58 microRNA 328 Rattus norvegicus 0-7 28638225-0 2017 Sodium selenite ameliorates dextran sulfate sodium-induced chronic colitis in mice by decreasing Th1, Th17, and gammadeltaT and increasing CD4(+)CD25(+) regulatory T-cell responses. Sodium Selenite 0-15 negative elongation factor complex member C/D, Th1l Mus musculus 97-100 28638225-0 2017 Sodium selenite ameliorates dextran sulfate sodium-induced chronic colitis in mice by decreasing Th1, Th17, and gammadeltaT and increasing CD4(+)CD25(+) regulatory T-cell responses. Sodium Selenite 0-15 CD4 antigen Mus musculus 139-142 28446133-10 2017 Furthermore, sodium selenite- injected rat pups had significantly higher levels of malondialdehyde, glutathione reductase enzyme activity, and calcium levels, which were reduced to control levels upon treatment with NACA. Sodium Selenite 13-28 glutathione-disulfide reductase Rattus norvegicus 100-121 29202485-5 2017 The aim of this study was to evaluate the effect of two antioxidants, alpha-tocopheryl succinate (alpha-TOS) and sodium selenite, on Pax6 gene expression levels in the forebrain and cerebellum of Golden Syrian hamsters chronically exposed to arsenic in drinking water. Sodium Selenite 113-128 paired box protein Pax-6 Mesocricetus auratus 133-137 29202485-8 2017 In the presence of arsenic, treatment with alpha-TOS did not modify Pax6 expression in nervous tissues; however, sodium selenite completely restored Pax6 expression in the arsenic-exposed hamster forebrain, but not the cerebellum. Sodium Selenite 113-128 paired box protein Pax-6 Mesocricetus auratus 149-153 27813686-3 2017 Here, we find out whether the effect of sodium selenite and selenomethionine on telomerase activity in human umbilical cord-derived mesenchymal stem cells (hUCMSCs) is associated with different levels of c-Myc and p53 expression. Sodium Selenite 40-55 MYC proto-oncogene, bHLH transcription factor Homo sapiens 204-209 27813686-3 2017 Here, we find out whether the effect of sodium selenite and selenomethionine on telomerase activity in human umbilical cord-derived mesenchymal stem cells (hUCMSCs) is associated with different levels of c-Myc and p53 expression. Sodium Selenite 40-55 tumor protein p53 Homo sapiens 214-217 28123581-6 2017 Sodium selenite supplementation increased glutathione peroxidase 1 (GPx-1) activity in a dose- and time-dependent manner. Sodium Selenite 0-15 glutathione peroxidase 1 Homo sapiens 42-66 28123581-6 2017 Sodium selenite supplementation increased glutathione peroxidase 1 (GPx-1) activity in a dose- and time-dependent manner. Sodium Selenite 0-15 glutathione peroxidase 1 Homo sapiens 68-73 28123581-7 2017 The sodium selenite dose that induced the highest GPx-1 activity was determined to be 50 nM for 72 h prior to radiotherapy. Sodium Selenite 4-19 glutathione peroxidase 1 Homo sapiens 50-55 28123581-8 2017 The half-maximal inhibitory concentration of sodium selenite in CHEK-1 cells was 3.6 microM. Sodium Selenite 45-60 checkpoint kinase 1 Homo sapiens 64-70 28123581-12 2017 In addition, combined treatment with 50 nM sodium selenite and 2 Gy X-ray irradiation reduced the expression levels of cleaved PARP protein, compared with 2 Gy X-ray irradiation alone; however, this reduction was not statistically significant (P=0.423). Sodium Selenite 43-58 poly(ADP-ribose) polymerase 1 Homo sapiens 127-131 28123581-13 2017 These results suggest that 50 nM sodium selenite supplementation administered for 72 h prior to irradiation may protect CHEK-1 cells from irradiation-induced damage by inhibiting irradiation-induced apoptosis. Sodium Selenite 33-48 checkpoint kinase 1 Homo sapiens 120-126 27477809-8 2016 Furthermore, sodium selenite increased the expression level of SBP1 and decreased the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and the Wnt pathway components and its downstream targets, including beta-catenin, GSK-3beta, c-myc and cyclinD1 in these cell lines. Sodium Selenite 13-28 catenin beta 1 Homo sapiens 216-228 26944060-6 2016 When the concentration of sodium selenite and SeMet was 1 mumol Se/L while MeSeCys was 0.1 and 1 mumol Se/L, SelP concentrations for serine combined with selenocompounds groups were significantly higher than that of selenocompounds used alone. Sodium Selenite 26-41 selenoprotein P Homo sapiens 109-113 27533281-3 2016 This study investigated whether sodium selenite can suppress Th1/Th17-mediated experimental colitis. Sodium Selenite 32-47 negative elongation factor complex member C/D, Th1l Mus musculus 61-64 27533281-9 2016 Pretreatment with sodium selenite restored interleukin-10 and Foxp3 excretion, as well as reducing the levels of interferon-gamma and interleukin-17A. Sodium Selenite 18-33 interleukin 10 Mus musculus 43-57 27533281-9 2016 Pretreatment with sodium selenite restored interleukin-10 and Foxp3 excretion, as well as reducing the levels of interferon-gamma and interleukin-17A. Sodium Selenite 18-33 forkhead box P3 Mus musculus 62-67 27533281-9 2016 Pretreatment with sodium selenite restored interleukin-10 and Foxp3 excretion, as well as reducing the levels of interferon-gamma and interleukin-17A. Sodium Selenite 18-33 interferon gamma Mus musculus 113-129 27533281-9 2016 Pretreatment with sodium selenite restored interleukin-10 and Foxp3 excretion, as well as reducing the levels of interferon-gamma and interleukin-17A. Sodium Selenite 18-33 interleukin 17A Mus musculus 134-149 27477809-0 2016 Sodium Selenite Inhibits Proliferation of Gastric Cancer Cells by Inducing SBP1 Expression. Sodium Selenite 0-15 selenium binding protein 1 Homo sapiens 75-79 27477809-8 2016 Furthermore, sodium selenite increased the expression level of SBP1 and decreased the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and the Wnt pathway components and its downstream targets, including beta-catenin, GSK-3beta, c-myc and cyclinD1 in these cell lines. Sodium Selenite 13-28 selenium binding protein 1 Homo sapiens 63-67 27477809-8 2016 Furthermore, sodium selenite increased the expression level of SBP1 and decreased the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and the Wnt pathway components and its downstream targets, including beta-catenin, GSK-3beta, c-myc and cyclinD1 in these cell lines. Sodium Selenite 13-28 NFE2 like bZIP transcription factor 2 Homo sapiens 96-139 27477809-8 2016 Furthermore, sodium selenite increased the expression level of SBP1 and decreased the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and the Wnt pathway components and its downstream targets, including beta-catenin, GSK-3beta, c-myc and cyclinD1 in these cell lines. Sodium Selenite 13-28 NFE2 like bZIP transcription factor 2 Homo sapiens 141-145 27477809-8 2016 Furthermore, sodium selenite increased the expression level of SBP1 and decreased the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and the Wnt pathway components and its downstream targets, including beta-catenin, GSK-3beta, c-myc and cyclinD1 in these cell lines. Sodium Selenite 13-28 glycogen synthase kinase 3 beta Homo sapiens 230-239 27477809-8 2016 Furthermore, sodium selenite increased the expression level of SBP1 and decreased the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and the Wnt pathway components and its downstream targets, including beta-catenin, GSK-3beta, c-myc and cyclinD1 in these cell lines. Sodium Selenite 13-28 MYC proto-oncogene, bHLH transcription factor Homo sapiens 241-246 27477809-8 2016 Furthermore, sodium selenite increased the expression level of SBP1 and decreased the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and the Wnt pathway components and its downstream targets, including beta-catenin, GSK-3beta, c-myc and cyclinD1 in these cell lines. Sodium Selenite 13-28 cyclin D1 Homo sapiens 251-259 27477809-9 2016 However, these effects of sodium selenite were attenuated in SGC7901 and N87 cells by knockdown of SBP1 expression. Sodium Selenite 26-41 selenium binding protein 1 Homo sapiens 99-103 27477809-10 2016 Thus, the sodium selenite-induced SBP1 expression is associated with the inhibition of cell proliferation and with the induced apoptosis. Sodium Selenite 10-25 selenium binding protein 1 Homo sapiens 34-38 26286659-0 2016 Sodium Selenite Decreased HDAC Activity, Cell Proliferation and Induced Apoptosis in Three Human Glioblastoma Cells. Sodium Selenite 0-15 histone deacetylase 9 Homo sapiens 26-30 25581026-7 2015 CLIC1 was shown to reduce sodium selenite and dehydroascorbate in a glutathione-dependent manner. Sodium Selenite 26-41 chloride intracellular channel 1 Homo sapiens 0-5 26702744-1 2016 BACKGROUND: Sodium selenite and ginsenoside Rh2 (G-Rh2) are well known for their anticancer properties and have been exploited as a new therapeutic approach. Sodium Selenite 12-27 Rh associated glycoprotein Homo sapiens 51-54 26702744-5 2016 RESULTS: The results showed that sodium selenite and G-Rh2 combination have a synergistic effect on cell growth inhibition (57%) compared with sodium selenite (25%) and G-Rh2 alone (28%) after 24 hours of treatment. Sodium Selenite 33-48 Rh associated glycoprotein Homo sapiens 171-174 26702744-7 2016 The results also indicated that Bax/Bcl2 ratio and caspase-3 expression, known as proapoptotic factors, were increased in the presence of sodium selenite and G-Rh2 alone. Sodium Selenite 138-153 BCL2 associated X, apoptosis regulator Homo sapiens 32-35 26702744-7 2016 The results also indicated that Bax/Bcl2 ratio and caspase-3 expression, known as proapoptotic factors, were increased in the presence of sodium selenite and G-Rh2 alone. Sodium Selenite 138-153 BCL2 apoptosis regulator Homo sapiens 36-40 26702744-7 2016 The results also indicated that Bax/Bcl2 ratio and caspase-3 expression, known as proapoptotic factors, were increased in the presence of sodium selenite and G-Rh2 alone. Sodium Selenite 138-153 caspase 3 Homo sapiens 51-60 26105025-4 2015 Western blot analysis and TCF/LEF-optimized promoter EGFP (TOPEGFP) assay showed that both beta-catenin protein levels and TCF/LEF transcription were up-regulated during insulin-transferrin-sodium selenite (ITS)-induced chondrogenic differentiation. Sodium Selenite 190-205 catenin (cadherin associated protein), beta 1 Mus musculus 91-103 25876085-8 2015 Moreover, the expression pattern of Selu mRNA in muscle, liver, kidney, heart, spleen, lung, testis, and brain was analyzed with real-time quantitative PCR in young male chickens fed a Se-deficient corn-soybean meal basal diet supplemented with 0.0 and 0.3 mg Se/kg in the form of sodium selenite. Sodium Selenite 281-296 peroxiredoxin like 2A Gallus gallus 36-40 26402162-4 2015 We evaluated the effect of sodium selenite on IL6-induced disruption on deiodinase function. Sodium Selenite 27-42 interleukin 6 Homo sapiens 46-49 26402162-12 2015 In conclusion, although sodium selenite reduces IL6-induced redox imbalance it does not fully repair deiodinase function. Sodium Selenite 24-39 interleukin 6 Homo sapiens 48-51 26006036-9 2015 Furthermore, augmentation of GPX1 activity directly by sodium selenite supplementation or transfection of a GPX1 expression plasmid decreased dextrose-induced oxidative stress but not ER stress, while GPX1 knockout enhanced oxidative stress but had no effect on ER stress. Sodium Selenite 55-70 glutathione peroxidase 1 Homo sapiens 29-33 25981166-8 2015 Cell incubation with sodium selenite alleviated the inhibitory effects on TrxR and glucose-6-phosphate dehydrogenase. Sodium Selenite 21-36 peroxiredoxin 5 Homo sapiens 74-78 25981166-8 2015 Cell incubation with sodium selenite alleviated the inhibitory effects on TrxR and glucose-6-phosphate dehydrogenase. Sodium Selenite 21-36 glucose-6-phosphate dehydrogenase Homo sapiens 83-116 25014023-4 2014 HD mice, which were supplemented with sodium selenite from 6 to 14 weeks of age, demonstrated increased motor endurance, decreased loss of brain weight, decreased mutant huntingtin aggregate burden and decreased brain oxidized glutathione levels. Sodium Selenite 38-53 huntingtin Mus musculus 170-180 25526081-7 2014 However, supplementation of dietary sodium selenite at the concentration of 0.4 mg/kg Se may ameliorate AFB1-induced apoptosis by increasing Bcl-2 mRNA expression, and decreasing Bax and Caspase-3 mRNA expression. Sodium Selenite 36-51 BCL2 apoptosis regulator Homo sapiens 141-146 25526081-7 2014 However, supplementation of dietary sodium selenite at the concentration of 0.4 mg/kg Se may ameliorate AFB1-induced apoptosis by increasing Bcl-2 mRNA expression, and decreasing Bax and Caspase-3 mRNA expression. Sodium Selenite 36-51 BCL2 associated X, apoptosis regulator Homo sapiens 179-182 25526081-7 2014 However, supplementation of dietary sodium selenite at the concentration of 0.4 mg/kg Se may ameliorate AFB1-induced apoptosis by increasing Bcl-2 mRNA expression, and decreasing Bax and Caspase-3 mRNA expression. Sodium Selenite 36-51 caspase 3 Homo sapiens 187-196 25109896-9 2014 Overall, these results provide strong evidence that sodium selenite (selenium) can inhibit cell death and tau phosphorylation induced by TNF-alpha in neuroblastoma cells, through the inhibition GSK-3beta and Akt phosphorylation. Sodium Selenite 52-67 tumor necrosis factor Homo sapiens 137-146 25198010-0 2014 Sodium selenite inhibits leukemia HL-60 cell proliferation and induces cell apoptosis by enhancing the phosphorylation of JNK1 and increasing the expression of p21 and p27. Sodium Selenite 0-15 mitogen-activated protein kinase 8 Homo sapiens 122-126 25198010-0 2014 Sodium selenite inhibits leukemia HL-60 cell proliferation and induces cell apoptosis by enhancing the phosphorylation of JNK1 and increasing the expression of p21 and p27. Sodium Selenite 0-15 cyclin dependent kinase inhibitor 1A Homo sapiens 160-163 25198010-0 2014 Sodium selenite inhibits leukemia HL-60 cell proliferation and induces cell apoptosis by enhancing the phosphorylation of JNK1 and increasing the expression of p21 and p27. Sodium Selenite 0-15 interferon alpha inducible protein 27 Homo sapiens 168-171 25109896-2 2014 This study was performed to investigate whether sodium selenite may inhibit the hyperphosphorylation of tau induced by treatment with tumor necrosis factor-alpha (TNF-alpha). Sodium Selenite 48-63 tumor necrosis factor Homo sapiens 134-161 25109896-2 2014 This study was performed to investigate whether sodium selenite may inhibit the hyperphosphorylation of tau induced by treatment with tumor necrosis factor-alpha (TNF-alpha). Sodium Selenite 48-63 tumor necrosis factor Homo sapiens 163-172 25109896-9 2014 Overall, these results provide strong evidence that sodium selenite (selenium) can inhibit cell death and tau phosphorylation induced by TNF-alpha in neuroblastoma cells, through the inhibition GSK-3beta and Akt phosphorylation. Sodium Selenite 52-67 glycogen synthase kinase 3 beta Homo sapiens 194-203 25109896-9 2014 Overall, these results provide strong evidence that sodium selenite (selenium) can inhibit cell death and tau phosphorylation induced by TNF-alpha in neuroblastoma cells, through the inhibition GSK-3beta and Akt phosphorylation. Sodium Selenite 52-67 AKT serine/threonine kinase 1 Homo sapiens 208-211 26989732-9 2014 CONCLUSIONS: Our results indicate that sodium selenite might be a potent antioxidant that exerts beneficial effects on both GPX and CAT activities in alloxan-induced type 1 diabetic rats. Sodium Selenite 39-54 catalase Rattus norvegicus 132-135 24997453-2 2014 The aim of this present investigation is to study the endoplasmic reticulum (ER) stress-mediated activation of unfolded protein response (UPR), overproduction of reactive oxygen species (ROS), and suppression of Nrf2/Keap1-dependent antioxidant protection through endoplasmic reticulum-associated degradation (ERAD) pathway and Keap1 promoter DNA demethylation in human lens epithelial cells (HLECs) treated with sodium selenite. Sodium Selenite 413-428 kelch like ECH associated protein 1 Homo sapiens 217-222 24997453-2 2014 The aim of this present investigation is to study the endoplasmic reticulum (ER) stress-mediated activation of unfolded protein response (UPR), overproduction of reactive oxygen species (ROS), and suppression of Nrf2/Keap1-dependent antioxidant protection through endoplasmic reticulum-associated degradation (ERAD) pathway and Keap1 promoter DNA demethylation in human lens epithelial cells (HLECs) treated with sodium selenite. Sodium Selenite 413-428 NFE2 like bZIP transcription factor 2 Homo sapiens 212-216 24994457-6 2014 At 5 muM, sodium selenite inhibited cell proliferation associated with a blockage in the G2 phase and induced DNA fragmentation leading to caspase-3-dependent apoptosis cell death. Sodium Selenite 10-25 latexin Homo sapiens 5-8 24994457-6 2014 At 5 muM, sodium selenite inhibited cell proliferation associated with a blockage in the G2 phase and induced DNA fragmentation leading to caspase-3-dependent apoptosis cell death. Sodium Selenite 10-25 caspase 3 Homo sapiens 139-148 24994457-7 2014 At low doses (<1 muM), SeMet and sodium selenite induced glutathione peroxidase-1 (GPX1) activity and selenoproteinW1 (SEPW1) transcript expression but metalloproteinase (MMP)-1 was only induced by sodium selenite. Sodium Selenite 36-51 latexin Homo sapiens 20-23 24994457-7 2014 At low doses (<1 muM), SeMet and sodium selenite induced glutathione peroxidase-1 (GPX1) activity and selenoproteinW1 (SEPW1) transcript expression but metalloproteinase (MMP)-1 was only induced by sodium selenite. Sodium Selenite 36-51 glutathione peroxidase 1 Homo sapiens 60-84 24994457-7 2014 At low doses (<1 muM), SeMet and sodium selenite induced glutathione peroxidase-1 (GPX1) activity and selenoproteinW1 (SEPW1) transcript expression but metalloproteinase (MMP)-1 was only induced by sodium selenite. Sodium Selenite 36-51 glutathione peroxidase 1 Homo sapiens 86-90 24994457-7 2014 At low doses (<1 muM), SeMet and sodium selenite induced glutathione peroxidase-1 (GPX1) activity and selenoproteinW1 (SEPW1) transcript expression but metalloproteinase (MMP)-1 was only induced by sodium selenite. Sodium Selenite 36-51 matrix metallopeptidase 1 Homo sapiens 155-180 25169040-0 2014 SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX-trial): study design of an international multicenter randomized double-blinded controlled trial of high dose sodium-selenite administration in high-risk cardiac surgical patients. Sodium Selenite 0-15 NK2 homeobox 5 Homo sapiens 58-61 25169040-8 2014 DISCUSSION: The SUSTAIN-CSX study is a multicenter trial to investigate the effect of a perioperative high dosage sodium selenite supplementation in high-risk cardiac surgical patients. Sodium Selenite 115-130 NK2 homeobox 5 Homo sapiens 24-27 24997453-6 2014 Sodium selenite also activated the mRNA expressions of passive DNA demethylation pathway enzymes such as Dnmt1, Dnmt3a, and Dnmt3b, and active DNA demethylation pathway enzyme, Tet1 leading to DNA demethylation in the Keap1 promoter of HLECs. Sodium Selenite 0-15 DNA methyltransferase 1 Homo sapiens 105-110 24997453-6 2014 Sodium selenite also activated the mRNA expressions of passive DNA demethylation pathway enzymes such as Dnmt1, Dnmt3a, and Dnmt3b, and active DNA demethylation pathway enzyme, Tet1 leading to DNA demethylation in the Keap1 promoter of HLECs. Sodium Selenite 0-15 DNA methyltransferase 3 alpha Homo sapiens 112-118 24997453-6 2014 Sodium selenite also activated the mRNA expressions of passive DNA demethylation pathway enzymes such as Dnmt1, Dnmt3a, and Dnmt3b, and active DNA demethylation pathway enzyme, Tet1 leading to DNA demethylation in the Keap1 promoter of HLECs. Sodium Selenite 0-15 DNA methyltransferase 3 beta Homo sapiens 124-130 24997453-6 2014 Sodium selenite also activated the mRNA expressions of passive DNA demethylation pathway enzymes such as Dnmt1, Dnmt3a, and Dnmt3b, and active DNA demethylation pathway enzyme, Tet1 leading to DNA demethylation in the Keap1 promoter of HLECs. Sodium Selenite 0-15 tet methylcytosine dioxygenase 1 Homo sapiens 177-181 24997453-6 2014 Sodium selenite also activated the mRNA expressions of passive DNA demethylation pathway enzymes such as Dnmt1, Dnmt3a, and Dnmt3b, and active DNA demethylation pathway enzyme, Tet1 leading to DNA demethylation in the Keap1 promoter of HLECs. Sodium Selenite 0-15 kelch like ECH associated protein 1 Homo sapiens 218-223 24997453-8 2014 Overexpression Keap1 protein suppresses the Nrf2 protein through ERAD leading to suppression of Nrf2/Keap1 dependent antioxidant protection in the HLECs treated with sodium selenite. Sodium Selenite 166-181 kelch like ECH associated protein 1 Homo sapiens 15-20 24997453-8 2014 Overexpression Keap1 protein suppresses the Nrf2 protein through ERAD leading to suppression of Nrf2/Keap1 dependent antioxidant protection in the HLECs treated with sodium selenite. Sodium Selenite 166-181 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 24997453-8 2014 Overexpression Keap1 protein suppresses the Nrf2 protein through ERAD leading to suppression of Nrf2/Keap1 dependent antioxidant protection in the HLECs treated with sodium selenite. Sodium Selenite 166-181 NFE2 like bZIP transcription factor 2 Homo sapiens 96-100 24997453-8 2014 Overexpression Keap1 protein suppresses the Nrf2 protein through ERAD leading to suppression of Nrf2/Keap1 dependent antioxidant protection in the HLECs treated with sodium selenite. Sodium Selenite 166-181 kelch like ECH associated protein 1 Homo sapiens 101-106 23770201-5 2013 Sodium selenite supplementation also suppressed 4-ClBQ-induced decrease in sepp1 expression, which was associated with a significant inhibition in cell death. Sodium Selenite 0-15 selenoprotein P Homo sapiens 75-80 24579724-4 2014 Pretreatment with sodium selenite or taurine produces significant depletion in MDA, NAG, cystatin C, nephrin and IL-6 levels in concomitant with significant elevation in serum NO level as compared to HgCl2 group. Sodium Selenite 18-33 O-GlcNAcase Rattus norvegicus 84-87 24579724-4 2014 Pretreatment with sodium selenite or taurine produces significant depletion in MDA, NAG, cystatin C, nephrin and IL-6 levels in concomitant with significant elevation in serum NO level as compared to HgCl2 group. Sodium Selenite 18-33 cystatin C Rattus norvegicus 89-99 24579724-4 2014 Pretreatment with sodium selenite or taurine produces significant depletion in MDA, NAG, cystatin C, nephrin and IL-6 levels in concomitant with significant elevation in serum NO level as compared to HgCl2 group. Sodium Selenite 18-33 NPHS1 adhesion molecule, nephrin Rattus norvegicus 101-108 24579724-4 2014 Pretreatment with sodium selenite or taurine produces significant depletion in MDA, NAG, cystatin C, nephrin and IL-6 levels in concomitant with significant elevation in serum NO level as compared to HgCl2 group. Sodium Selenite 18-33 interleukin 6 Rattus norvegicus 113-117 24857817-5 2014 A significant decrease in the uric acid, creatinine, blood urea nitrogen and MDA levels and a significant increase in the SOD, CAT and GPx activities were observed in the supplementation of sodium selenite and/or vitamin E to mercuric chloride-treated groups. Sodium Selenite 190-205 catalase Rattus norvegicus 127-130 24515840-4 2014 The results show that the mRNA expression of SelW were effectively increased after treatment with sodium selenite, and H2O2-induced cell apoptosis was significantly decreased and cell viability was significantly increased. Sodium Selenite 98-113 selenoprotein W Gallus gallus 45-49 24191312-9 2013 Sodium selenite supplementation markedly reduced total bilirubin and ALT activity and restored the antioxidant enzymes (SOD and GSH) and MDA and catalase activity. Sodium Selenite 0-15 catalase Rattus norvegicus 145-153 24291358-5 2014 In the presence of SS, ovarian cytochrome c and caspase 3 expressions triggered by radiotherapy were decreased. Sodium Selenite 19-21 caspase 3 Rattus norvegicus 48-57 24039907-10 2013 Furthermore, GPx1 protein levels increased in human breast adenocarcinoma MCF7 cells exposed to beta-estradiol and sodium selenite.In conclusion, our data provide evidence that SNPs in SEPP1 and GPX1 modulate risk of BC and that eGPx activity is modified by SNPs in SEPP1, GPX4 and GPX1 and by estrogens. Sodium Selenite 115-130 glutathione peroxidase 1 Homo sapiens 13-17 24039907-10 2013 Furthermore, GPx1 protein levels increased in human breast adenocarcinoma MCF7 cells exposed to beta-estradiol and sodium selenite.In conclusion, our data provide evidence that SNPs in SEPP1 and GPX1 modulate risk of BC and that eGPx activity is modified by SNPs in SEPP1, GPX4 and GPX1 and by estrogens. Sodium Selenite 115-130 selenoprotein P Homo sapiens 185-190 24039907-10 2013 Furthermore, GPx1 protein levels increased in human breast adenocarcinoma MCF7 cells exposed to beta-estradiol and sodium selenite.In conclusion, our data provide evidence that SNPs in SEPP1 and GPX1 modulate risk of BC and that eGPx activity is modified by SNPs in SEPP1, GPX4 and GPX1 and by estrogens. Sodium Selenite 115-130 glutathione peroxidase 1 Homo sapiens 195-199 24039907-10 2013 Furthermore, GPx1 protein levels increased in human breast adenocarcinoma MCF7 cells exposed to beta-estradiol and sodium selenite.In conclusion, our data provide evidence that SNPs in SEPP1 and GPX1 modulate risk of BC and that eGPx activity is modified by SNPs in SEPP1, GPX4 and GPX1 and by estrogens. Sodium Selenite 115-130 selenoprotein P Homo sapiens 266-271 24039907-10 2013 Furthermore, GPx1 protein levels increased in human breast adenocarcinoma MCF7 cells exposed to beta-estradiol and sodium selenite.In conclusion, our data provide evidence that SNPs in SEPP1 and GPX1 modulate risk of BC and that eGPx activity is modified by SNPs in SEPP1, GPX4 and GPX1 and by estrogens. Sodium Selenite 115-130 glutathione peroxidase 4 Homo sapiens 273-277 24039907-10 2013 Furthermore, GPx1 protein levels increased in human breast adenocarcinoma MCF7 cells exposed to beta-estradiol and sodium selenite.In conclusion, our data provide evidence that SNPs in SEPP1 and GPX1 modulate risk of BC and that eGPx activity is modified by SNPs in SEPP1, GPX4 and GPX1 and by estrogens. Sodium Selenite 115-130 glutathione peroxidase 1 Homo sapiens 282-286 23797303-3 2013 This thin film was hydrated with a sodium selenite (5.8 muM) solution to form multilamellar vesicles and homogenized under high pressure to yield unilamellar nanoliposomes. Sodium Selenite 35-50 latexin Homo sapiens 56-59 23369933-6 2013 Supplementation of sodium selenite and/or vitamin E to mercury-induced groups declined lipid peroxidation, increased SOD, CAT, GPx activities. Sodium Selenite 19-34 catalase Rattus norvegicus 122-125 23893182-0 2013 Sodium selenite induces apoptosis in colon cancer cells via Bax-dependent mitochondrial pathway. Sodium Selenite 0-15 BCL2 associated X, apoptosis regulator Homo sapiens 60-63 23481027-3 2013 The objective of this study was to evaluate the effects of sodium selenite on the transcript levels of type I (DIO1) and II (DIO2) deiodinases in the primary culture of ovine and bovine fetal thyroid. Sodium Selenite 59-74 type I iodothyronine deiodinase Bos taurus 111-115 23481027-3 2013 The objective of this study was to evaluate the effects of sodium selenite on the transcript levels of type I (DIO1) and II (DIO2) deiodinases in the primary culture of ovine and bovine fetal thyroid. Sodium Selenite 59-74 iodothyronine deiodinase 2 Bos taurus 125-129 23481027-4 2013 By culture of fetal thyrocytes in the presence or absence of sodium selenite, and quantification of DIO1 and DIO2 transcripts using real-time reverse transcription polymerase chain reaction (RT-qPCR), we found that sodium selenite is able to increase the abundance of transcripts for DIO1 and DIO2 genes. Sodium Selenite 215-230 type I iodothyronine deiodinase Bos taurus 100-104 23481027-4 2013 By culture of fetal thyrocytes in the presence or absence of sodium selenite, and quantification of DIO1 and DIO2 transcripts using real-time reverse transcription polymerase chain reaction (RT-qPCR), we found that sodium selenite is able to increase the abundance of transcripts for DIO1 and DIO2 genes. Sodium Selenite 215-230 iodothyronine deiodinase 2 Bos taurus 109-113 23481027-4 2013 By culture of fetal thyrocytes in the presence or absence of sodium selenite, and quantification of DIO1 and DIO2 transcripts using real-time reverse transcription polymerase chain reaction (RT-qPCR), we found that sodium selenite is able to increase the abundance of transcripts for DIO1 and DIO2 genes. Sodium Selenite 215-230 type I iodothyronine deiodinase Bos taurus 284-288 23481027-4 2013 By culture of fetal thyrocytes in the presence or absence of sodium selenite, and quantification of DIO1 and DIO2 transcripts using real-time reverse transcription polymerase chain reaction (RT-qPCR), we found that sodium selenite is able to increase the abundance of transcripts for DIO1 and DIO2 genes. Sodium Selenite 215-230 iodothyronine deiodinase 2 Bos taurus 293-297 23481027-6 2013 This indicates that in the presence of sodium selenite higher levels of DIO1 and DIO2 enzymes are produced, which are able to convert T4 to T3. Sodium Selenite 39-54 type I iodothyronine deiodinase Bos taurus 72-76 23481027-6 2013 This indicates that in the presence of sodium selenite higher levels of DIO1 and DIO2 enzymes are produced, which are able to convert T4 to T3. Sodium Selenite 39-54 iodothyronine deiodinase 2 Bos taurus 81-85 23481027-7 2013 In conclusion, we have shown that sodium selenite is increasing the abundance of DIO1 and DIO2 transcripts and increasing the production and release of T3 from cultured fetal thyrocytes. Sodium Selenite 34-49 type I iodothyronine deiodinase Bos taurus 81-85 23481027-7 2013 In conclusion, we have shown that sodium selenite is increasing the abundance of DIO1 and DIO2 transcripts and increasing the production and release of T3 from cultured fetal thyrocytes. Sodium Selenite 34-49 iodothyronine deiodinase 2 Bos taurus 90-94 23468186-4 2013 In addition, gene expression of five selenoproteins (GPx1, Sel H, Sel N, Sel P, and Sel W) was up-regulated and two selenoproteins (SPS2 and Sel O) was down-regulated by sodium selenite (Se) in both ATDC5 and C28/I2 cells. Sodium Selenite 170-185 selenophosphate synthetase 2 Mus musculus 132-136 23589036-16 2013 We therefore propose that sodium selenite induces the apoptosis of PC-3 cells mainly through the mitochondrial pathway, but also via ER stress and HIF-1alpha mediated pathways. Sodium Selenite 26-41 hypoxia inducible factor 1 subunit alpha Homo sapiens 147-157 22922758-5 2012 Moreover, knockdown of CerS1 abrogated sodium selenite-induced mitophagy, and stable LC3B knockdown protected against CerS1- and C(18)-ceramide-dependent mitophagy and blocked tumor suppression in vivo. Sodium Selenite 39-54 ceramide synthase 1 Homo sapiens 23-28 23054870-5 2012 The results showed that the sodium selenite medium enhanced the mRNA expression of SelW, Myf-5, MRF4, and myogenin in chicken myoblasts. Sodium Selenite 28-43 selenoprotein W Gallus gallus 83-87 23054870-5 2012 The results showed that the sodium selenite medium enhanced the mRNA expression of SelW, Myf-5, MRF4, and myogenin in chicken myoblasts. Sodium Selenite 28-43 myogenic factor 5 Gallus gallus 89-94 23054870-5 2012 The results showed that the sodium selenite medium enhanced the mRNA expression of SelW, Myf-5, MRF4, and myogenin in chicken myoblasts. Sodium Selenite 28-43 myogenic factor 6 Gallus gallus 96-100 23054870-5 2012 The results showed that the sodium selenite medium enhanced the mRNA expression of SelW, Myf-5, MRF4, and myogenin in chicken myoblasts. Sodium Selenite 28-43 myogenin Gallus gallus 106-114 23360166-4 2013 The results showed that P, SS, and SP could significantly down-regulate the average mRNA levels of Hsp70 (17.3, 23.7, and 40.1%) and Hsp27 (22.4, 24.4, and 44.7%) of the tissues, respectively (P < 0.05), whereas SS and SP could significantly elevate Se concentration, GPx1 activity and mRNA level (P < 0.05). Sodium Selenite 27-29 heat shock protein family A (Hsp70) member 4 Homo sapiens 99-104 23360166-4 2013 The results showed that P, SS, and SP could significantly down-regulate the average mRNA levels of Hsp70 (17.3, 23.7, and 40.1%) and Hsp27 (22.4, 24.4, and 44.7%) of the tissues, respectively (P < 0.05), whereas SS and SP could significantly elevate Se concentration, GPx1 activity and mRNA level (P < 0.05). Sodium Selenite 27-29 heat shock protein family B (small) member 1 Homo sapiens 133-138 23360166-4 2013 The results showed that P, SS, and SP could significantly down-regulate the average mRNA levels of Hsp70 (17.3, 23.7, and 40.1%) and Hsp27 (22.4, 24.4, and 44.7%) of the tissues, respectively (P < 0.05), whereas SS and SP could significantly elevate Se concentration, GPx1 activity and mRNA level (P < 0.05). Sodium Selenite 27-29 glutathione peroxidase 1 Homo sapiens 271-275 23360166-4 2013 The results showed that P, SS, and SP could significantly down-regulate the average mRNA levels of Hsp70 (17.3, 23.7, and 40.1%) and Hsp27 (22.4, 24.4, and 44.7%) of the tissues, respectively (P < 0.05), whereas SS and SP could significantly elevate Se concentration, GPx1 activity and mRNA level (P < 0.05). Sodium Selenite 215-217 heat shock protein family A (Hsp70) member 4 Homo sapiens 99-104 23439548-3 2013 Sodium selenite (Na(2)SeO(3) 0.5 mumol/L) increased the expression of full-length SelM and inhibited the expression of truncated SelM. Sodium Selenite 0-15 selenoprotein M Homo sapiens 83-87 23439548-3 2013 Sodium selenite (Na(2)SeO(3) 0.5 mumol/L) increased the expression of full-length SelM and inhibited the expression of truncated SelM. Sodium Selenite 0-15 selenoprotein M Homo sapiens 130-134 23442931-3 2013 The aim of this work was to test in vitro the effect of sodium selenite on the human hepatoma cell lines, HepG2 and Huh7, to assess its effect on the expression of GPX1, SELK and SELENBP1 and also to evaluate its action on inflammation determinants such as cytokines. Sodium Selenite 56-71 MIR7-3 host gene Homo sapiens 116-120 23442931-3 2013 The aim of this work was to test in vitro the effect of sodium selenite on the human hepatoma cell lines, HepG2 and Huh7, to assess its effect on the expression of GPX1, SELK and SELENBP1 and also to evaluate its action on inflammation determinants such as cytokines. Sodium Selenite 56-71 glutathione peroxidase 1 Homo sapiens 164-168 23442931-3 2013 The aim of this work was to test in vitro the effect of sodium selenite on the human hepatoma cell lines, HepG2 and Huh7, to assess its effect on the expression of GPX1, SELK and SELENBP1 and also to evaluate its action on inflammation determinants such as cytokines. Sodium Selenite 56-71 selenoprotein K Homo sapiens 170-174 23442931-3 2013 The aim of this work was to test in vitro the effect of sodium selenite on the human hepatoma cell lines, HepG2 and Huh7, to assess its effect on the expression of GPX1, SELK and SELENBP1 and also to evaluate its action on inflammation determinants such as cytokines. Sodium Selenite 56-71 selenium binding protein 1 Homo sapiens 179-187 23010420-12 2013 When matching the participating patients to a historical control group without sodium-selenite administration, the chosen strategy was associated with a decrease in SAPS II (23 +- 7 versus 29 +- 8, P = 0.005) and SOFA scores (4 +- 3 versus 7 +- 2, P = 0.007) on the first postoperative day, but was unable to improve the postoperative outcome in patients staying >1 d in ICU. Sodium Selenite 79-94 src kinase associated phosphoprotein 2 Homo sapiens 165-169 25198662-0 2013 Activation of p53 by sodium selenite switched human leukemia NB4 cells from autophagy to apoptosis. Sodium Selenite 21-36 tumor protein p53 Homo sapiens 14-17 21948612-13 2012 Testis gene expression of glutathione peroxidase 4, as determined using quantitative PCR, was increased (P < 0.01) in boars fed organic Se compared with those fed sodium selenite. Sodium Selenite 166-181 glutathione peroxidase 4 Homo sapiens 26-50 22449708-0 2012 Sodium selenite-induced activation of DAPK promotes autophagy in human leukemia HL60 cells. Sodium Selenite 0-15 death associated protein kinase 1 Homo sapiens 38-42 22721804-4 2012 We showed that sodium selenite modulated both the extrinsic and intrinsic apoptotic pathways, which were interconnected by Bid truncation. Sodium Selenite 15-30 BH3 interacting domain death agonist Homo sapiens 123-126 22721804-6 2012 Sodium selenite also increased autophagy, as indicated by an increase in microtubule-associated protein light chain-3 (LC3) puncta, accumulation of LC3II, and elevation of autophagic flux. Sodium Selenite 0-15 microtubule associated protein 1 light chain 3 alpha Homo sapiens 119-122 22246726-2 2012 Superoxide dismutase (SOD) activity and contents of cordycepin, cordycepic acid, and organic selenium of fruit bodies were sodium selenite concentration dependent; contents of adenosine and cordycep polysaccharides were significantly enhanced by adding sodium selenite in the substrates, but not proportional to sodium selenite concentrations. Sodium Selenite 123-138 SOD Triticum aestivum 22-25 22246726-2 2012 Superoxide dismutase (SOD) activity and contents of cordycepin, cordycepic acid, and organic selenium of fruit bodies were sodium selenite concentration dependent; contents of adenosine and cordycep polysaccharides were significantly enhanced by adding sodium selenite in the substrates, but not proportional to sodium selenite concentrations. Sodium Selenite 253-268 SOD Triticum aestivum 22-25 22246726-2 2012 Superoxide dismutase (SOD) activity and contents of cordycepin, cordycepic acid, and organic selenium of fruit bodies were sodium selenite concentration dependent; contents of adenosine and cordycep polysaccharides were significantly enhanced by adding sodium selenite in the substrates, but not proportional to sodium selenite concentrations. Sodium Selenite 253-268 SOD Triticum aestivum 22-25 22509550-0 2011 [Effects of sodium selenite on the expressions of beta-catenin and its target cyclin D1 in colorectal cancer cells HCT 116 and SW480]. Sodium Selenite 12-27 catenin beta 1 Homo sapiens 50-62 22177986-5 2012 In the regenerating livers, the activity of the cytosolic selenoenzyme thioredoxin reductase (TrxR1) was briefly and transiently increased, an increase further potentiated by sodium selenite. Sodium Selenite 175-190 peroxiredoxin 5 Rattus norvegicus 71-92 22400102-8 2012 The expression of HLA-DR molecules induced by interferon-gamma in the presence of sodium selenite of various concentration was measured by fluorescence-activated cell sorter. Sodium Selenite 82-97 interferon gamma Homo sapiens 46-62 21809053-4 2012 Sodium selenite-induced oxidative stress in spleens of chickens was evidenced by decrease in glutathione peroxidase, superoxide dismutase, and catalase activities and increase in malondialdehyde contents. Sodium Selenite 0-15 catalase Gallus gallus 143-151 21739163-3 2011 In this study, we used murine osteoblast-like MC3T3-E1 cells to examine the impact of sodium fluoride (NaF) and/or sodium selenite (Na2SeO3) on the OPG/RANKL system. Sodium Selenite 115-130 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 148-151 23236409-11 2012 In conclusion, sodium selenite showed a radioprotective effect and improved folliculogenesis through increasing ovarian granulosa cells proliferation, estradiol and FSH secretion, and GPx activity, whilst decreasing lipid peroxidation and oxidative stress, leading to inhibition of the apoptosis pathway through decreasing the expressions of caspase 3 and cytochrome c. Sodium Selenite 15-30 caspase 3 Rattus norvegicus 342-351 22509550-0 2011 [Effects of sodium selenite on the expressions of beta-catenin and its target cyclin D1 in colorectal cancer cells HCT 116 and SW480]. Sodium Selenite 12-27 cyclin D1 Homo sapiens 78-87 22509550-1 2011 OBJECTIVE: To explore the effects of sodium selenite on the expressions of beta-catenin and cyclin D1 in colorectal cancer cells HCT 116 and SW480. Sodium Selenite 37-52 catenin beta 1 Homo sapiens 75-87 22509550-1 2011 OBJECTIVE: To explore the effects of sodium selenite on the expressions of beta-catenin and cyclin D1 in colorectal cancer cells HCT 116 and SW480. Sodium Selenite 37-52 cyclin D1 Homo sapiens 92-101 22509550-6 2011 RESULTS: Sodium selenite inhibited the expression of beta-catenin and transcription of its target such as cyclin D1. Sodium Selenite 9-24 catenin beta 1 Homo sapiens 53-65 22509550-6 2011 RESULTS: Sodium selenite inhibited the expression of beta-catenin and transcription of its target such as cyclin D1. Sodium Selenite 9-24 cyclin D1 Homo sapiens 106-115 22509550-9 2011 CONCLUSIONS: Sodium selenite can lower the expression levels of beta-catenin and its target cyclin D1, during which the proteasome-mediated degradative pathway may be involved. Sodium Selenite 13-28 catenin beta 1 Homo sapiens 64-76 22509550-9 2011 CONCLUSIONS: Sodium selenite can lower the expression levels of beta-catenin and its target cyclin D1, during which the proteasome-mediated degradative pathway may be involved. Sodium Selenite 13-28 cyclin D1 Homo sapiens 92-101 22509550-10 2011 The decreased interaction between beta-catenin and TCF4 due to sodium selenite may be also involved in the regulation of beta-catenin signaling. Sodium Selenite 63-78 catenin beta 1 Homo sapiens 34-46 22509550-10 2011 The decreased interaction between beta-catenin and TCF4 due to sodium selenite may be also involved in the regulation of beta-catenin signaling. Sodium Selenite 63-78 transcription factor 7 like 2 Homo sapiens 51-55 22509550-10 2011 The decreased interaction between beta-catenin and TCF4 due to sodium selenite may be also involved in the regulation of beta-catenin signaling. Sodium Selenite 63-78 catenin beta 1 Homo sapiens 121-133 21170571-7 2011 A significant increase in SelW mRNA levels was observed in the gastrointestinal tract tissues of chickens fed the diets containing 1-3 mg/kg sodium selenite while decreased SelW mRNA levels were observed in the esophagus, crop, proventriculus, gizzard, duodenum and cecum in chickens fed the diet containing 5 mg/kg sodium selenite. Sodium Selenite 141-156 selenoprotein W Gallus gallus 26-30 21190829-8 2011 Incubations with 100 nM sodium selenite, l- or dl-selenocystine, selenodiglutathione or selenomethyl-selenocysteine increased SEPP concentrations in the culture medium up to 6.5-fold over control after 72 h. In comparison, sodium selenate, l- or dl-selenomethionine or methylseleninic acid was less effective and increased SEPP by 2.5-fold under these conditions. Sodium Selenite 24-39 selenoprotein P Homo sapiens 126-130 21190829-8 2011 Incubations with 100 nM sodium selenite, l- or dl-selenocystine, selenodiglutathione or selenomethyl-selenocysteine increased SEPP concentrations in the culture medium up to 6.5-fold over control after 72 h. In comparison, sodium selenate, l- or dl-selenomethionine or methylseleninic acid was less effective and increased SEPP by 2.5-fold under these conditions. Sodium Selenite 24-39 selenoprotein P Homo sapiens 323-327 21549092-0 2011 Combined effect of sodium selenite and docetaxel on PC3 metastatic prostate cancer cell line. Sodium Selenite 19-34 chromobox 8 Homo sapiens 52-55 21549092-5 2011 Here we report the effect of docetaxel and sodium selenite combination on the PC3 prostate cancer cell line, derived from bone metastasis. Sodium Selenite 43-58 chromobox 8 Homo sapiens 78-81 21549092-9 2011 On the other hand, cytochrome C, Bax/Bcl2 ratio and caspase-3, known as proapoptotic factors, significantly increased in the presence of sodium selenite alone, but not in the presence of docetaxel in monotherapy or in combination with sodium selenite. Sodium Selenite 137-152 cytochrome c, somatic Homo sapiens 19-31 21549092-9 2011 On the other hand, cytochrome C, Bax/Bcl2 ratio and caspase-3, known as proapoptotic factors, significantly increased in the presence of sodium selenite alone, but not in the presence of docetaxel in monotherapy or in combination with sodium selenite. Sodium Selenite 137-152 BCL2 associated X, apoptosis regulator Homo sapiens 33-36 21549092-9 2011 On the other hand, cytochrome C, Bax/Bcl2 ratio and caspase-3, known as proapoptotic factors, significantly increased in the presence of sodium selenite alone, but not in the presence of docetaxel in monotherapy or in combination with sodium selenite. Sodium Selenite 137-152 BCL2 apoptosis regulator Homo sapiens 37-41 21549092-9 2011 On the other hand, cytochrome C, Bax/Bcl2 ratio and caspase-3, known as proapoptotic factors, significantly increased in the presence of sodium selenite alone, but not in the presence of docetaxel in monotherapy or in combination with sodium selenite. Sodium Selenite 137-152 caspase 3 Homo sapiens 52-61 20387002-8 2011 Sodium selenite-induced oxidative stress in liver tissue of rats as evidenced by increase in lipid peroxidation and glutathione peroxidase activity, while catalase was significantly decreased. Sodium Selenite 0-15 catalase Rattus norvegicus 155-163 21207117-9 2011 The SeW gene is ubiquitously expressed in heart, skeletal muscle, brain, testis, spleen, kidney, lung, liver, stomach and pancreas in chickens fed a commercial diet supplemented with sodium selenite. Sodium Selenite 183-198 selenoprotein W Gallus gallus 4-7 21170571-7 2011 A significant increase in SelW mRNA levels was observed in the gastrointestinal tract tissues of chickens fed the diets containing 1-3 mg/kg sodium selenite while decreased SelW mRNA levels were observed in the esophagus, crop, proventriculus, gizzard, duodenum and cecum in chickens fed the diet containing 5 mg/kg sodium selenite. Sodium Selenite 316-331 selenoprotein W Gallus gallus 26-30 19904745-0 2010 Tumor inhibition by sodium selenite is associated with activation of c-Jun NH2-terminal kinase 1 and suppression of beta-catenin signaling. Sodium Selenite 20-35 catenin (cadherin associated protein), beta 1 Mus musculus 116-128 20709753-5 2010 We show that hMLH1 complementation sensitizes HCT 116 cells to methylseleninic acid, methylselenocysteine, and sodium selenite via reactive oxygen species and facilitates the selenium-induced oxidative 8-oxoguanine damage, DNA breaks, G(2)/M checkpoint response, and ATM pathway activation. Sodium Selenite 111-126 mutL homolog 1 Homo sapiens 13-18 21850177-6 2011 Time-course effect of sodium selenite on HSP70 expression was studied by reverse transcription polymerase chain reaction (RT-PCR) and western blot. Sodium Selenite 22-37 heat shock protein family A (Hsp70) member 4 Homo sapiens 41-46 21850177-8 2011 RESULTS: Our data showed that sodium selenite increased cell viabilities and prevented 1,2-DHN-induced apoptosis through phosphorylation and nuclear translocation of Akt. Sodium Selenite 30-45 AKT serine/threonine kinase 1 Homo sapiens 166-169 19904745-3 2010 Muc2/p21 double mutant mice with a selenium-enriched (sodium selenite) diet for 12 or 24 weeks, and found that sodium selenite significantly inhibited intestinal tumor formation in these animals (p < 0.01), which was associated with phosphorylation of JNK1 and suppression of beta-catenin and COX2. Sodium Selenite 111-126 mucin 2 Mus musculus 0-4 19904745-3 2010 Muc2/p21 double mutant mice with a selenium-enriched (sodium selenite) diet for 12 or 24 weeks, and found that sodium selenite significantly inhibited intestinal tumor formation in these animals (p < 0.01), which was associated with phosphorylation of JNK1 and suppression of beta-catenin and COX2. Sodium Selenite 111-126 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 5-8 19904745-3 2010 Muc2/p21 double mutant mice with a selenium-enriched (sodium selenite) diet for 12 or 24 weeks, and found that sodium selenite significantly inhibited intestinal tumor formation in these animals (p < 0.01), which was associated with phosphorylation of JNK1 and suppression of beta-catenin and COX2. Sodium Selenite 111-126 mitogen-activated protein kinase 8 Mus musculus 255-259 19904745-3 2010 Muc2/p21 double mutant mice with a selenium-enriched (sodium selenite) diet for 12 or 24 weeks, and found that sodium selenite significantly inhibited intestinal tumor formation in these animals (p < 0.01), which was associated with phosphorylation of JNK1 and suppression of beta-catenin and COX2. Sodium Selenite 111-126 catenin (cadherin associated protein), beta 1 Mus musculus 279-291 19904745-3 2010 Muc2/p21 double mutant mice with a selenium-enriched (sodium selenite) diet for 12 or 24 weeks, and found that sodium selenite significantly inhibited intestinal tumor formation in these animals (p < 0.01), which was associated with phosphorylation of JNK1 and suppression of beta-catenin and COX2. Sodium Selenite 111-126 cytochrome c oxidase II, mitochondrial Mus musculus 296-300 19904745-6 2010 Reduced JNK1 expression by small RNA interference abrogated sufficient activation of JNK1 by sodium selenite, leading to reduced inhibition of the beta-catenin signaling, resulting in reduced efficacy of inhibiting cell proliferation. Sodium Selenite 93-108 mitogen-activated protein kinase 8 Mus musculus 8-12 19904745-6 2010 Reduced JNK1 expression by small RNA interference abrogated sufficient activation of JNK1 by sodium selenite, leading to reduced inhibition of the beta-catenin signaling, resulting in reduced efficacy of inhibiting cell proliferation. Sodium Selenite 93-108 mitogen-activated protein kinase 8 Mus musculus 85-89 19904745-6 2010 Reduced JNK1 expression by small RNA interference abrogated sufficient activation of JNK1 by sodium selenite, leading to reduced inhibition of the beta-catenin signaling, resulting in reduced efficacy of inhibiting cell proliferation. Sodium Selenite 93-108 catenin (cadherin associated protein), beta 1 Mus musculus 147-159 19904745-7 2010 Taken together, our data demonstrate that sodium selenite inhibits intestinal carcinogenesis in vivo and in vitro through activating JNK1 and suppressing beta-catenin signaling, a novel anticancer mechanism of selenium. Sodium Selenite 42-57 mitogen-activated protein kinase 8 Mus musculus 133-137 19904745-7 2010 Taken together, our data demonstrate that sodium selenite inhibits intestinal carcinogenesis in vivo and in vitro through activating JNK1 and suppressing beta-catenin signaling, a novel anticancer mechanism of selenium. Sodium Selenite 42-57 catenin (cadherin associated protein), beta 1 Mus musculus 154-166 20353787-1 2010 Following our previous finding that sodium selenite induces apoptosis in human leukemia NB4 cells, we now show that the expression of the critical antioxidant enzyme manganese superoxide dismutase (MnSOD) is remarkably elevated during this process. Sodium Selenite 36-51 superoxide dismutase 2 Homo sapiens 166-196 20353787-1 2010 Following our previous finding that sodium selenite induces apoptosis in human leukemia NB4 cells, we now show that the expression of the critical antioxidant enzyme manganese superoxide dismutase (MnSOD) is remarkably elevated during this process. Sodium Selenite 36-51 superoxide dismutase 2 Homo sapiens 198-203 20114070-3 2010 The results showed that SelS protein expression was markedly increased by 10 mM beta-ME and 100 nM sodium selenite in HepG2 cells. Sodium Selenite 99-114 selenoprotein S Homo sapiens 24-28 20194099-0 2010 Alteration of osteocalcin mRNA expression in ovine osteoblasts in dependence of sodium fluoride and sodium selenite medium supplementation. Sodium Selenite 100-115 bone gamma-carboxyglutamate protein Homo sapiens 14-25 20194099-1 2010 Objective of this study was to assess the quantification of osteocalcin (OCN) expression by ovine osteoblasts cultured with different concentrations of sodium fluoride (F) and sodium selenite (Se) to evaluate the interaction of these agents on OCN expression in vitro . Sodium Selenite 176-191 bone gamma-carboxyglutamate protein Homo sapiens 60-71 20194099-1 2010 Objective of this study was to assess the quantification of osteocalcin (OCN) expression by ovine osteoblasts cultured with different concentrations of sodium fluoride (F) and sodium selenite (Se) to evaluate the interaction of these agents on OCN expression in vitro . Sodium Selenite 176-191 bone gamma-carboxyglutamate protein Homo sapiens 73-76 19933942-7 2009 Inhibition of arsenic biomethylation with sodium selenite abolished arsenic-induced ODD and invasiveness, colony formation, and MMP-2 and -9 hypersecretion in TRL1215 cells. Sodium Selenite 42-57 matrix metallopeptidase 2 Homo sapiens 128-140 19782065-5 2010 When Se in the form of sodium selenite was added in the cell culture, the reactivity of the histamine H(1)-receptor was increased as reported in our previous paper. Sodium Selenite 23-38 histamine receptor H1 Homo sapiens 92-115 19782065-6 2010 We here show that as a culture supplement, sodium selenite enhanced the activity of selenoprotein thioredoxin reductase (TrxR) and the calcium response to histamine stimulation, which were reversed by treating the cells with gold thioglucose, a nucleophilic drug that selectively modifies thiolate/selenolate groups. Sodium Selenite 43-58 peroxiredoxin 5 Homo sapiens 98-119 19782065-6 2010 We here show that as a culture supplement, sodium selenite enhanced the activity of selenoprotein thioredoxin reductase (TrxR) and the calcium response to histamine stimulation, which were reversed by treating the cells with gold thioglucose, a nucleophilic drug that selectively modifies thiolate/selenolate groups. Sodium Selenite 43-58 peroxiredoxin 5 Homo sapiens 121-125 19782065-7 2010 Sodium selenite most likely caused a reductive shift in the thiol/disulfide redox balance through increasing TrxR activity. Sodium Selenite 0-15 peroxiredoxin 5 Homo sapiens 109-113 19811770-0 2010 Sodium selenite inhibits the expression of VEGF, TGFbeta(1) and IL-6 induced by LPS in human PC3 cells via TLR4-NF-(K)B signaling blockage. Sodium Selenite 0-15 vascular endothelial growth factor A Homo sapiens 43-47 19811770-0 2010 Sodium selenite inhibits the expression of VEGF, TGFbeta(1) and IL-6 induced by LPS in human PC3 cells via TLR4-NF-(K)B signaling blockage. Sodium Selenite 0-15 transforming growth factor beta 1 Homo sapiens 49-59 19811770-0 2010 Sodium selenite inhibits the expression of VEGF, TGFbeta(1) and IL-6 induced by LPS in human PC3 cells via TLR4-NF-(K)B signaling blockage. Sodium Selenite 0-15 interleukin 6 Homo sapiens 64-68 19811770-0 2010 Sodium selenite inhibits the expression of VEGF, TGFbeta(1) and IL-6 induced by LPS in human PC3 cells via TLR4-NF-(K)B signaling blockage. Sodium Selenite 0-15 toll like receptor 4 Homo sapiens 107-111 19387567-4 2009 Selenoprotein W (SEPW1) was the only selenoprotein messenger RNA (mRNA) increased by both sodium selenite (specific) and high-Se serum (physiologic). Sodium Selenite 90-105 selenoprotein W Homo sapiens 0-15 19387567-4 2009 Selenoprotein W (SEPW1) was the only selenoprotein messenger RNA (mRNA) increased by both sodium selenite (specific) and high-Se serum (physiologic). Sodium Selenite 90-105 selenoprotein W Homo sapiens 17-22 20078935-0 2009 [Mechanism for downregulation of cytochrome c oxidase subunit IV in NB4 cells induced by sodium selenite]. Sodium Selenite 89-104 cytochrome c oxidase subunit 4I1 Homo sapiens 33-64 20078935-1 2009 OBJECTIVE: To explore the mechanism and significance of cytochrome c oxidase subunit IV (COX IV) downregulation during apoptosis of NB4 cells induced by sodium selenite. Sodium Selenite 153-168 cytochrome c oxidase subunit 4I1 Homo sapiens 56-87 20078935-1 2009 OBJECTIVE: To explore the mechanism and significance of cytochrome c oxidase subunit IV (COX IV) downregulation during apoptosis of NB4 cells induced by sodium selenite. Sodium Selenite 153-168 cytochrome c oxidase subunit 4I1 Homo sapiens 89-95 19602434-8 2009 Moreover, upon sodium selenite treatment, there was a tendency for cells to accumulate at G2 phase which was accompanied by the increasing expression of cyclin B1, Cdc2 p34, p21 and the sub G1 fraction of the cell cycle. Sodium Selenite 15-30 cyclin B1 Homo sapiens 153-162 19602434-8 2009 Moreover, upon sodium selenite treatment, there was a tendency for cells to accumulate at G2 phase which was accompanied by the increasing expression of cyclin B1, Cdc2 p34, p21 and the sub G1 fraction of the cell cycle. Sodium Selenite 15-30 cyclin dependent kinase 1 Homo sapiens 164-168 19602434-8 2009 Moreover, upon sodium selenite treatment, there was a tendency for cells to accumulate at G2 phase which was accompanied by the increasing expression of cyclin B1, Cdc2 p34, p21 and the sub G1 fraction of the cell cycle. Sodium Selenite 15-30 alpha and gamma adaptin binding protein Homo sapiens 169-172 19602434-8 2009 Moreover, upon sodium selenite treatment, there was a tendency for cells to accumulate at G2 phase which was accompanied by the increasing expression of cyclin B1, Cdc2 p34, p21 and the sub G1 fraction of the cell cycle. Sodium Selenite 15-30 H3 histone pseudogene 16 Homo sapiens 174-177 19265499-9 2009 Sodium selenite was effective in increasing the selenoprotein P concentration in normal and to a lesser degree in affected subjects. Sodium Selenite 0-15 selenoprotein P Homo sapiens 48-63 19453253-5 2009 SePP was isolated from plasma from healthy volunteers, before and after a 6-week supplementation with 100 microg sodium selenite, and from colon cancer patients and controls. Sodium Selenite 113-128 selenoprotein P Homo sapiens 0-4 19788862-0 2009 Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells. Sodium Selenite 61-76 AKT serine/threonine kinase 1 Homo sapiens 34-37 19788862-8 2009 In summary, sodium selenite increases NB4 cell apoptosis by autophagy inhibition through PI3K/Akt, and the inhibition of autophagy contributes to the up-regulation of apoptosis. Sodium Selenite 12-27 AKT serine/threonine kinase 1 Homo sapiens 94-97 19558795-0 2009 The subcellular distribution of MnSOD alters during sodium selenite-induced apoptosis. Sodium Selenite 52-67 superoxide dismutase 2 Homo sapiens 32-37 19558795-3 2009 In this study, we showed that 20 microM sodium selenite could alter subcellular distribution of MnSOD, namely a decrease in mitochondria and an increase in cytosol. Sodium Selenite 40-55 superoxide dismutase 2 Homo sapiens 96-101 19558795-4 2009 The alteration of subcellular distribution of MnSOD is dependent on the production of superoxide induced by sodium selenite. Sodium Selenite 108-123 superoxide dismutase 2 Homo sapiens 46-51 19373605-0 2009 Sodium selenite increases the activity of the tumor suppressor protein, PTEN, in DU-145 prostate cancer cells. Sodium Selenite 0-15 phosphatase and tensin homolog Homo sapiens 72-76 19373605-3 2009 In this study, we demonstrated that the activity of Trx reductase (TR) is increased by sevenfold in the human prostate cancer cell line, DU-145, after 5 days of sodium selenite (Se) treatment. Sodium Selenite 161-176 thioredoxin Homo sapiens 52-55 19544974-1 2009 Our previous study has shown that sodium selenite can cause apoptosis in acute promyelocytic leukemia-derived NB4 cells in a caspase-dependent manner involving Deltapsim disruption and cleavage of Bcl-2, but more detailed mechanism(s) remain unclear. Sodium Selenite 34-49 BCL2 apoptosis regulator Homo sapiens 197-202 19544974-2 2009 Here we showed that mitochondrial apoptosis signaling pathway played a vital role in apoptosis induced by sodium selenite based on the following findings: 1) cytochrome c release, activation of caspase 9, mitochondrial targeting, and oligermerization of Bax; 2) caspase 9, but not caspase 8, inhibitor could attenuate apoptosis; 3) downregulation of Bax and Bad by siRNA could delay sodium selenite-induced apoptosis. Sodium Selenite 106-121 cytochrome c, somatic Homo sapiens 158-170 19544974-2 2009 Here we showed that mitochondrial apoptosis signaling pathway played a vital role in apoptosis induced by sodium selenite based on the following findings: 1) cytochrome c release, activation of caspase 9, mitochondrial targeting, and oligermerization of Bax; 2) caspase 9, but not caspase 8, inhibitor could attenuate apoptosis; 3) downregulation of Bax and Bad by siRNA could delay sodium selenite-induced apoptosis. Sodium Selenite 106-121 caspase 9 Homo sapiens 194-203 19544974-2 2009 Here we showed that mitochondrial apoptosis signaling pathway played a vital role in apoptosis induced by sodium selenite based on the following findings: 1) cytochrome c release, activation of caspase 9, mitochondrial targeting, and oligermerization of Bax; 2) caspase 9, but not caspase 8, inhibitor could attenuate apoptosis; 3) downregulation of Bax and Bad by siRNA could delay sodium selenite-induced apoptosis. Sodium Selenite 106-121 BCL2 associated X, apoptosis regulator Homo sapiens 254-257 19544974-2 2009 Here we showed that mitochondrial apoptosis signaling pathway played a vital role in apoptosis induced by sodium selenite based on the following findings: 1) cytochrome c release, activation of caspase 9, mitochondrial targeting, and oligermerization of Bax; 2) caspase 9, but not caspase 8, inhibitor could attenuate apoptosis; 3) downregulation of Bax and Bad by siRNA could delay sodium selenite-induced apoptosis. Sodium Selenite 106-121 caspase 9 Homo sapiens 262-271 19544974-2 2009 Here we showed that mitochondrial apoptosis signaling pathway played a vital role in apoptosis induced by sodium selenite based on the following findings: 1) cytochrome c release, activation of caspase 9, mitochondrial targeting, and oligermerization of Bax; 2) caspase 9, but not caspase 8, inhibitor could attenuate apoptosis; 3) downregulation of Bax and Bad by siRNA could delay sodium selenite-induced apoptosis. Sodium Selenite 106-121 caspase 8 Homo sapiens 281-290 19544974-2 2009 Here we showed that mitochondrial apoptosis signaling pathway played a vital role in apoptosis induced by sodium selenite based on the following findings: 1) cytochrome c release, activation of caspase 9, mitochondrial targeting, and oligermerization of Bax; 2) caspase 9, but not caspase 8, inhibitor could attenuate apoptosis; 3) downregulation of Bax and Bad by siRNA could delay sodium selenite-induced apoptosis. Sodium Selenite 106-121 BCL2 associated X, apoptosis regulator Homo sapiens 350-353 19544974-2 2009 Here we showed that mitochondrial apoptosis signaling pathway played a vital role in apoptosis induced by sodium selenite based on the following findings: 1) cytochrome c release, activation of caspase 9, mitochondrial targeting, and oligermerization of Bax; 2) caspase 9, but not caspase 8, inhibitor could attenuate apoptosis; 3) downregulation of Bax and Bad by siRNA could delay sodium selenite-induced apoptosis. Sodium Selenite 383-398 BCL2 associated X, apoptosis regulator Homo sapiens 254-257 19544974-4 2009 Our findings here demonstrate that sodium selenite can induce apoptosis in NB4 cells through a mechanism involving ROS, activation of proapoptotic proteins Bad and Bax, Deltapsim disruption, release of cytochrome c, and consequent initiation of caspase cascade. Sodium Selenite 35-50 BCL2 associated X, apoptosis regulator Homo sapiens 164-167 19544974-4 2009 Our findings here demonstrate that sodium selenite can induce apoptosis in NB4 cells through a mechanism involving ROS, activation of proapoptotic proteins Bad and Bax, Deltapsim disruption, release of cytochrome c, and consequent initiation of caspase cascade. Sodium Selenite 35-50 cytochrome c, somatic Homo sapiens 202-214 19033020-9 2008 RESULTS: Sodium selenite and Se-methyl-selenocysteine hydrochloride increased GPx-1 protein and activity in a dose-dependent manner (P < .0001). Sodium Selenite 9-24 glutathione peroxidase 1 Homo sapiens 78-83 19033020-11 2008 Glutathione peroxidase 1 activity increased from 37.0 U/gHb (31.3-41.7) to 41.1 U/gHb (35.2-48.4) (P < .0001) in the 200 microg and from 38.1 U/gHb (33.2-43.8) to 42.6 U/gHb (35.0-49.1) (P < .0001) in the 500 microg sodium selenite group treated for 12-weeks. Sodium Selenite 222-237 glutathione peroxidase 1 Homo sapiens 0-24 19033020-13 2008 CONCLUSIONS: Sodium selenite supplementation increases GPx-1 activity in endothelial cells and in CAD patients. Sodium Selenite 13-28 glutathione peroxidase 1 Homo sapiens 55-60 18496816-4 2008 Our results show that approximately 64-72% of the strains lacking RAD9-dependent DNA repair or RAD6/RAD18 DNA damage tolerance pathway genes show reduced growth in sodium selenite versus approximately 28-36% in SeMet. Sodium Selenite 164-179 chromatin-binding protein RAD9 Saccharomyces cerevisiae S288C 66-70 18496816-4 2008 Our results show that approximately 64-72% of the strains lacking RAD9-dependent DNA repair or RAD6/RAD18 DNA damage tolerance pathway genes show reduced growth in sodium selenite versus approximately 28-36% in SeMet. Sodium Selenite 164-179 E2 ubiquitin-conjugating protein RAD6 Saccharomyces cerevisiae S288C 95-99 18496816-4 2008 Our results show that approximately 64-72% of the strains lacking RAD9-dependent DNA repair or RAD6/RAD18 DNA damage tolerance pathway genes show reduced growth in sodium selenite versus approximately 28-36% in SeMet. Sodium Selenite 164-179 E3 ubiquitin-protein ligase RAD18 Saccharomyces cerevisiae S288C 100-105 19238993-4 2008 RESULTS: Under the condition of alone treatment, sodium selenite (5.0 and 10.0 micromol/L) as well as arsenious acid (6.25, 12.5 and 25.0 micromol/L) resulted in significant increased levels of MDA and 8-OHdG, and inhibition of hOGG1 expression in HepG2 cells compared with solvent control (P < 0.05, P < 0.01). Sodium Selenite 49-64 8-oxoguanine DNA glycosylase Homo sapiens 228-233 19238993-8 2008 CONCLUSION: Sodium selenite at the concentrations of 5.0, 10.0 micromol/L and arsenious acid at the concentrations of 6.25, 12.5, 25.0 micromol/L induced enhanced oxidative stress and 8-OHdG production, and inhibition of hOGG1 expression, respectively. Sodium Selenite 12-27 8-oxoguanine DNA glycosylase Homo sapiens 221-226 18728404-0 2008 The JNK signaling pathway is involved in sodium-selenite-induced apoptosis mediated by reactive oxygen in HepG2 cells. Sodium Selenite 41-56 mitogen-activated protein kinase 8 Homo sapiens 4-7 18547722-0 2008 Sodium selenite inhibits gamma-secretase activity through activation of ERK. Sodium Selenite 0-15 mitogen-activated protein kinase 1 Homo sapiens 72-75 18405881-0 2008 Treatment of lung cancer cells with cytotoxic levels of sodium selenite: effects on the thioredoxin system. Sodium Selenite 56-71 thioredoxin Homo sapiens 88-99 18405881-7 2008 The complex regulation of TrxR1, involving the expression of many different transcript forms of mRNA, was investigated by real-time qPCR in lung cancer cell lines following treatment with toxic doses (2.5-10 microM) of sodium selenite. Sodium Selenite 219-234 thioredoxin reductase 1 Homo sapiens 26-31 18424227-0 2008 Rad52 has a role in the repair of sodium selenite-induced DNA damage in Saccharomyces cerevisiae. Sodium Selenite 34-49 recombinase RAD52 Saccharomyces cerevisiae S288C 0-5 18424227-7 2008 We report that the Rad52 protein is indispensable for repairing sodium selenite-induced DSB, suggesting a fundamental role of homologous recombination (HR) in this repair process. Sodium Selenite 64-79 recombinase RAD52 Saccharomyces cerevisiae S288C 19-24 17804075-8 2008 The inflammatory stimulus further elevated MnSOD levels in the whole-liver that was abrogated in sodium selenite supplementation due to reduced transcription of MnSOD in Kupffer cells. Sodium Selenite 97-112 superoxide dismutase 2 Rattus norvegicus 43-48 18215477-8 2008 We observed that when sodium selenite (SS) caused liver injury, both hepatic TrxR1 activity and hepatic GST activity increased. Sodium Selenite 22-37 thioredoxin reductase 1 Homo sapiens 77-82 18215477-8 2008 We observed that when sodium selenite (SS) caused liver injury, both hepatic TrxR1 activity and hepatic GST activity increased. Sodium Selenite 22-37 glutathione S-transferase kappa 1 Homo sapiens 104-107 18215477-8 2008 We observed that when sodium selenite (SS) caused liver injury, both hepatic TrxR1 activity and hepatic GST activity increased. Sodium Selenite 39-41 thioredoxin reductase 1 Homo sapiens 77-82 18215477-8 2008 We observed that when sodium selenite (SS) caused liver injury, both hepatic TrxR1 activity and hepatic GST activity increased. Sodium Selenite 39-41 glutathione S-transferase kappa 1 Homo sapiens 104-107 17804075-8 2008 The inflammatory stimulus further elevated MnSOD levels in the whole-liver that was abrogated in sodium selenite supplementation due to reduced transcription of MnSOD in Kupffer cells. Sodium Selenite 97-112 superoxide dismutase 2 Rattus norvegicus 161-166 17997286-2 2007 We tested some of the neuroprotective effects of sodium selenite in NPC cells by monitoring thioredoxin reductase (TR) expression, optimum H(2)O(2) removal, and consequent inhibition of pro-apoptotic events including cytochrome c release and caspase 3 and 9 activation. Sodium Selenite 49-64 caspase 3 Mus musculus 242-251 17633456-8 2007 Sodium selenite also downregulated Bcl-xl and activated Bax and Bid at protein level. Sodium Selenite 0-15 BCL2 like 1 Homo sapiens 35-41 18199979-10 2007 CONCLUSION: Sodium selenite induced apoptosis is accompanied by increased Bax expression. Sodium Selenite 12-27 BCL2 associated X, apoptosis regulator Homo sapiens 74-77 17342738-7 2007 The SS supplementation also decreased the BAX:BCL-xL transcript ratio, increased the expression of ERK1/2 and glutathione peroxidase (GPX) and reduced the level of Caspase 3 proteins (P < 0.05). Sodium Selenite 4-6 BCL2 associated X, apoptosis regulator Homo sapiens 42-45 17342738-7 2007 The SS supplementation also decreased the BAX:BCL-xL transcript ratio, increased the expression of ERK1/2 and glutathione peroxidase (GPX) and reduced the level of Caspase 3 proteins (P < 0.05). Sodium Selenite 4-6 BCL2 like 1 Homo sapiens 46-52 17342738-7 2007 The SS supplementation also decreased the BAX:BCL-xL transcript ratio, increased the expression of ERK1/2 and glutathione peroxidase (GPX) and reduced the level of Caspase 3 proteins (P < 0.05). Sodium Selenite 4-6 mitogen-activated protein kinase 3 Homo sapiens 99-105 17708798-0 2007 [Reversal effect of sodium selenite on multidrug resistance in K562/ADR cell line and its mechanisms]. Sodium Selenite 20-35 aldo-keto reductase family 1 member B Homo sapiens 68-71 17708798-1 2007 This study was purposed to investigate the reversal effect of sodium selenite on multidrug resistance in adriamycin-resistant leukemic cell line K562/ADR and its mechanisms. Sodium Selenite 62-77 aldo-keto reductase family 1 member B Homo sapiens 150-153 17708798-2 2007 The cytotoxicity and the reversal effect of sodium selenite on K562/ADR cells were assayed by MTT method; the apoptosis rate of K562 and K562/ADR cells were detected by flow cytometery, the mRNA expressions of mdr1 and bcl-2 were measured by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR). Sodium Selenite 44-59 aldo-keto reductase family 1 member B Homo sapiens 68-71 17708798-3 2007 The results showed that 10 micromol/L sodium selenite significantly increased the cytotoxicity of adriamycin to K562/ADR cell and the reverse index (RI) was 2.31; the early apoptosis rate of K562 cells was elevated after treatment with 5 micromol/L Na(2)SeO(3) for 48 hours; and the medium-term and late apoptosis rate was elevated after treatment with both 5 and 10 micromol/L Na(2)SeO(3) for 48 and 72 hours. Sodium Selenite 38-53 aldo-keto reductase family 1 member B Homo sapiens 117-120 17708798-6 2007 The expressions of mdr1 mRNA and bcl-2 mRNA were decreased significantly by 10 micromol/L sodium selenite. Sodium Selenite 90-105 ATP binding cassette subfamily B member 1 Homo sapiens 19-23 17708798-6 2007 The expressions of mdr1 mRNA and bcl-2 mRNA were decreased significantly by 10 micromol/L sodium selenite. Sodium Selenite 90-105 BCL2 apoptosis regulator Homo sapiens 33-38 17708798-7 2007 It is concluded that sodium selenite can reverse the multidrug resistance in K562/ADR partially by down-regulating the expressions of mdr1 mRNA and bcl-2 mRNA, and increasing apoptosis rate of K562/ADR cells. Sodium Selenite 21-36 aldo-keto reductase family 1 member B Homo sapiens 82-85 17708798-7 2007 It is concluded that sodium selenite can reverse the multidrug resistance in K562/ADR partially by down-regulating the expressions of mdr1 mRNA and bcl-2 mRNA, and increasing apoptosis rate of K562/ADR cells. Sodium Selenite 21-36 ATP binding cassette subfamily B member 1 Homo sapiens 134-138 17708798-7 2007 It is concluded that sodium selenite can reverse the multidrug resistance in K562/ADR partially by down-regulating the expressions of mdr1 mRNA and bcl-2 mRNA, and increasing apoptosis rate of K562/ADR cells. Sodium Selenite 21-36 BCL2 apoptosis regulator Homo sapiens 148-153 17708798-7 2007 It is concluded that sodium selenite can reverse the multidrug resistance in K562/ADR partially by down-regulating the expressions of mdr1 mRNA and bcl-2 mRNA, and increasing apoptosis rate of K562/ADR cells. Sodium Selenite 21-36 aldo-keto reductase family 1 member B Homo sapiens 198-201 17633456-8 2007 Sodium selenite also downregulated Bcl-xl and activated Bax and Bid at protein level. Sodium Selenite 0-15 BCL2 associated X, apoptosis regulator Homo sapiens 56-59 17633456-8 2007 Sodium selenite also downregulated Bcl-xl and activated Bax and Bid at protein level. Sodium Selenite 0-15 BH3 interacting domain death agonist Homo sapiens 64-67 17633456-9 2007 Pretreatment with antioxidant MnTmPy almost fully abrogated the proapoptotic effect of sodium selenite prevented the cleavage of Bid protein and in turn the mitochondrail transmembrane potential loss. Sodium Selenite 87-102 BH3 interacting domain death agonist Homo sapiens 129-132 17633456-11 2007 CONCLUSIONS: Sodium selenite may induce apoptosis by inducing ROS production in NB4 cells, which leads to the downregulation of Bcl-xl, upregulation of Bax, and cleavage and activation of Bid. Sodium Selenite 13-28 BCL2 like 1 Homo sapiens 128-134 17633456-11 2007 CONCLUSIONS: Sodium selenite may induce apoptosis by inducing ROS production in NB4 cells, which leads to the downregulation of Bcl-xl, upregulation of Bax, and cleavage and activation of Bid. Sodium Selenite 13-28 BCL2 associated X, apoptosis regulator Homo sapiens 152-155 17633456-11 2007 CONCLUSIONS: Sodium selenite may induce apoptosis by inducing ROS production in NB4 cells, which leads to the downregulation of Bcl-xl, upregulation of Bax, and cleavage and activation of Bid. Sodium Selenite 13-28 BH3 interacting domain death agonist Homo sapiens 188-191 17346688-0 2007 Sodium selenite inhibits interleukin-6-mediated androgen receptor activation in prostate cancer cells via upregulation of c-Jun. Sodium Selenite 0-15 interleukin 6 Homo sapiens 25-38 17158527-7 2007 The pro-angiogenesis effect of arsenite or b-FGF was significantly (P < 0.01) blocked by dimethyl selenone, diphenyl selenone, sodium selenite or Se-methyl selenocysteine. Sodium Selenite 130-145 fibroblast growth factor 2 Gallus gallus 43-48 17346688-0 2007 Sodium selenite inhibits interleukin-6-mediated androgen receptor activation in prostate cancer cells via upregulation of c-Jun. Sodium Selenite 0-15 androgen receptor Homo sapiens 48-65 17346688-0 2007 Sodium selenite inhibits interleukin-6-mediated androgen receptor activation in prostate cancer cells via upregulation of c-Jun. Sodium Selenite 0-15 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 122-127 17346688-4 2007 METHODS: Cell proliferation, prostate-specific antigen, gene transfer, and Western blot assays were used to study the effects of sodium selenite and methylseleninic acid on IL-6 mediated AR action on an AR expressing human prostate cancer cell line, LNCaP. Sodium Selenite 129-144 interleukin 6 Homo sapiens 173-177 17346688-4 2007 METHODS: Cell proliferation, prostate-specific antigen, gene transfer, and Western blot assays were used to study the effects of sodium selenite and methylseleninic acid on IL-6 mediated AR action on an AR expressing human prostate cancer cell line, LNCaP. Sodium Selenite 129-144 androgen receptor Homo sapiens 187-189 17346688-5 2007 RESULTS: We found that sodium selenite, but not methylseleninic acid, significantly (p<0.05) inhibited IL-6-induced trans-activating activity of AR and cell proliferation in LNCaP cells. Sodium Selenite 23-38 interleukin 6 Homo sapiens 106-110 17346688-5 2007 RESULTS: We found that sodium selenite, but not methylseleninic acid, significantly (p<0.05) inhibited IL-6-induced trans-activating activity of AR and cell proliferation in LNCaP cells. Sodium Selenite 23-38 androgen receptor Homo sapiens 148-150 17346688-6 2007 Interestingly, although sodium selenite did not show effect on activation of both STAT3 and ERK1/2 in the presence of IL-6, an increased expression of c-Jun was detected in cells after treatment with sodium selenite. Sodium Selenite 200-215 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 151-156 17346688-8 2007 CONCLUSIONS: Taken together, our results suggest that sodium selenite not methylseleninic acid can inhibit IL-6-mediated AR activation by increased c-Jun in LNCaP cells. Sodium Selenite 54-69 interleukin 6 Homo sapiens 107-111 17346688-8 2007 CONCLUSIONS: Taken together, our results suggest that sodium selenite not methylseleninic acid can inhibit IL-6-mediated AR activation by increased c-Jun in LNCaP cells. Sodium Selenite 54-69 androgen receptor Homo sapiens 121-123 17346688-8 2007 CONCLUSIONS: Taken together, our results suggest that sodium selenite not methylseleninic acid can inhibit IL-6-mediated AR activation by increased c-Jun in LNCaP cells. Sodium Selenite 54-69 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 148-153 17346688-9 2007 Sodium selenite may be a proper selenium form for further testing its potency on intervening IL-6-mediated PCa progression. Sodium Selenite 0-15 interleukin 6 Homo sapiens 93-97 17394769-0 2007 Requirement for ERK activity in sodium selenite-induced apoptosis of acute promyelocytic leukemia-derived NB4 cells. Sodium Selenite 32-47 mitogen-activated protein kinase 1 Homo sapiens 16-19 17394769-2 2007 Here we demonstrate a requirement for extracellular signal-regulated protein kinase (ERK) in mediating sodium selenite -induced apoptosis in NB4 cell. Sodium Selenite 103-118 mitogen-activated protein kinase 1 Homo sapiens 38-83 17394769-2 2007 Here we demonstrate a requirement for extracellular signal-regulated protein kinase (ERK) in mediating sodium selenite -induced apoptosis in NB4 cell. Sodium Selenite 103-118 mitogen-activated protein kinase 1 Homo sapiens 85-88 17028378-0 2006 Dose-related influence of sodium selenite on apoptosis in human thyroid follicles in vitro induced by iodine, EGF, TGF-beta, and H2O2. Sodium Selenite 26-41 epidermal growth factor Homo sapiens 110-113 17916949-0 2007 The impact of high-dose sodium selenite therapy on Bcl-2 expression in adult non-Hodgkin"s lymphoma patients: correlation with response and survival. Sodium Selenite 24-39 BCL2 apoptosis regulator Homo sapiens 51-56 17916949-1 2007 The present study was undertaken to explore the effect of administration of high doses of sodium selenite on the expression of Bcl-2 in patients with non-Hodgkin"s lymphoma (NHL). Sodium Selenite 90-105 BCL2 apoptosis regulator Homo sapiens 127-132 17916949-5 2007 Sodium selenite administration resulted in significant decline of Bcl-2 level after therapy in group A-II (8.6 +/- 6.9 ng/ml vs 3 6.9 +/- 7.9 ng/ml, P < 0.05). Sodium Selenite 0-15 BCL2 apoptosis regulator Homo sapiens 66-71 17916949-5 2007 Sodium selenite administration resulted in significant decline of Bcl-2 level after therapy in group A-II (8.6 +/- 6.9 ng/ml vs 3 6.9 +/- 7.9 ng/ml, P < 0.05). Sodium Selenite 0-15 NLR family pyrin domain containing 3 Homo sapiens 101-105 17916949-9 2007 It is concluded that sodium selenite administration at the dosage and duration chosen acts as a down regulator of Bcl-2 and improves clinical outcome. Sodium Selenite 21-36 BCL2 apoptosis regulator Homo sapiens 114-119 17052796-2 2007 We determined the subtoxic range of selenium concentration (as sodium selenite) required to increase and maintain the expression of anti-oxidant selenoproteins gluthathione peroxidases GPX1 and GPX4 at a constant level in cultures of human lung adenocarcinoma cell lines (H460, H1703 and H1944) and in HPL1D, a non-transformed lung epithelial cell line. Sodium Selenite 63-78 glutathione peroxidase 1 Homo sapiens 185-189 17052796-2 2007 We determined the subtoxic range of selenium concentration (as sodium selenite) required to increase and maintain the expression of anti-oxidant selenoproteins gluthathione peroxidases GPX1 and GPX4 at a constant level in cultures of human lung adenocarcinoma cell lines (H460, H1703 and H1944) and in HPL1D, a non-transformed lung epithelial cell line. Sodium Selenite 63-78 glutathione peroxidase 4 Homo sapiens 194-198 17142313-8 2006 Furthermore, purified recombinant SepSecS converts Sep-tRNA(Sec) into Sec-tRNA(Sec) in vitro in the presence of sodium selenite and purified recombinant E. coli selenophosphate synthetase (SelD). Sodium Selenite 112-127 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase Homo sapiens 34-41 17028378-0 2006 Dose-related influence of sodium selenite on apoptosis in human thyroid follicles in vitro induced by iodine, EGF, TGF-beta, and H2O2. Sodium Selenite 26-41 transforming growth factor beta 1 Homo sapiens 115-123 17028378-10 2006 Sodium selenite might increase the antioxidative potential in human thyroid follicles in vitro and therefore diminish the apoptosis induced by TGF-beta, EGF, iodide, and even H2O2. Sodium Selenite 0-15 transforming growth factor beta 1 Homo sapiens 143-151 17028378-10 2006 Sodium selenite might increase the antioxidative potential in human thyroid follicles in vitro and therefore diminish the apoptosis induced by TGF-beta, EGF, iodide, and even H2O2. Sodium Selenite 0-15 epidermal growth factor Homo sapiens 153-156 16889072-4 2006 The antioxidants, vitamin C and sodium selenite, directly increased GSH content while diminishing ROS formation and DNA damage in H. pylori-infected SGC-7901 cells, indicating that vitamin C and sodium selenite can protect gastric cells against H. pylori damage. Sodium Selenite 32-47 sarcoglycan beta Homo sapiens 149-152 16889072-4 2006 The antioxidants, vitamin C and sodium selenite, directly increased GSH content while diminishing ROS formation and DNA damage in H. pylori-infected SGC-7901 cells, indicating that vitamin C and sodium selenite can protect gastric cells against H. pylori damage. Sodium Selenite 195-210 sarcoglycan beta Homo sapiens 149-152 16944776-10 2006 Sodium selenite at the doses of 5, 10, and 20 micromol/kg caused c-myc, c-fos, and c-jun overexpression obviously. Sodium Selenite 0-15 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 65-70 16944776-10 2006 Sodium selenite at the doses of 5, 10, and 20 micromol/kg caused c-myc, c-fos, and c-jun overexpression obviously. Sodium Selenite 0-15 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 72-77 16632112-7 2006 Preincubation of astrocytes with hepatocyte-derived SeP mimicks the protective effect of low-molecular-weight selenocompounds such as sodium selenite or selenomethionine against oxidative damage, shielding astrocytes from t-BHP-induced cytotoxicity. Sodium Selenite 134-149 selenoprotein P Homo sapiens 52-55 16111838-2 2006 Incubation of osteoclast-like cells differentiated from RAW 264.7 cells with sodium selenite induced apoptosis as revealed by morphological changes, internucleosomal DNA fragmentation, and activation of caspase-3. Sodium Selenite 77-92 caspase 3 Mus musculus 203-212 16569192-8 2006 The inhibition of PARP cleavage by PCGEM1 overexpression was also observed in LNCaP-PCGEM1 cells incubated with etoposide and sodium selenite. Sodium Selenite 126-141 poly(ADP-ribose) polymerase 1 Homo sapiens 18-22 16569192-8 2006 The inhibition of PARP cleavage by PCGEM1 overexpression was also observed in LNCaP-PCGEM1 cells incubated with etoposide and sodium selenite. Sodium Selenite 126-141 PCGEM1 prostate-specific transcript Homo sapiens 35-41 16569192-8 2006 The inhibition of PARP cleavage by PCGEM1 overexpression was also observed in LNCaP-PCGEM1 cells incubated with etoposide and sodium selenite. Sodium Selenite 126-141 PCGEM1 prostate-specific transcript Homo sapiens 84-90 16600092-1 2006 OBJECTIVE: To study the effects of sodium selenite on expression of telomerase reverse transcriptase mRNA, c-Myc and p53 induced by cadmium chloride in rat liver. Sodium Selenite 35-50 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 107-112 16600092-1 2006 OBJECTIVE: To study the effects of sodium selenite on expression of telomerase reverse transcriptase mRNA, c-Myc and p53 induced by cadmium chloride in rat liver. Sodium Selenite 35-50 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 117-120 16222869-6 2005 Melatonin, sodium selenite, NAC and quercetin greatly promoted the lymphocytes proliferation to IL-2. Sodium Selenite 11-26 interleukin 2 Homo sapiens 96-100 16097802-9 2005 MALDI-TOF mass spectra analysis of hGSTO1-1 after reaction with GSH and sodium selenite indicated that selenium was integrated into hGSTO1-1 molecules. Sodium Selenite 72-87 glutathione S-transferase omega 1 Homo sapiens 35-43 16258850-6 2005 Initially, a cloning corresponding to human selenoprotein M (hSelM) was chosen for investigation further because SelM induced by sodium selenite, a pro-oxidant, may have a functional role in catalyze the free radicals. Sodium Selenite 129-144 selenoprotein M Homo sapiens 44-59 16258850-6 2005 Initially, a cloning corresponding to human selenoprotein M (hSelM) was chosen for investigation further because SelM induced by sodium selenite, a pro-oxidant, may have a functional role in catalyze the free radicals. Sodium Selenite 129-144 selenoprotein M Homo sapiens 62-66 16258850-9 2005 Moreover, the levels of green fluorescence on hSelM fusion protein with EGFP were suppressed in the cells transfected with hPS2m, and its levels had actually increased by treatments of sodium selenite. Sodium Selenite 185-200 presenilin 2 Homo sapiens 123-127 15935149-3 2005 Treatment with sodium selenite induced cytotoxity in a dose-dependent manner in both TrxR1 over-expressing and control cells. Sodium Selenite 15-30 thioredoxin reductase 1 Homo sapiens 85-90 15871179-3 2005 Insulin-transferrin-sodium selenite supplemented medium was used to culture the feeder layers for 24 hours. Sodium Selenite 20-35 transferrin Mus musculus 8-19 15480664-0 2004 Sodium selenite induces apoptosis in acute promyelocytic leukemia-derived NB4 cells by a caspase-3-dependent mechanism and a redox pathway different from that of arsenic trioxide. Sodium Selenite 0-15 caspase 3 Homo sapiens 89-98 15378764-4 2004 The ovalbumin-induced degradation of annexin-1 was blocked by pretreatment of mice with the antioxidant N-acetylcysteine (NAC) or with sodium selenite, both of which have previously been shown to exert anti-inflammatory effects in this asthma model. Sodium Selenite 135-150 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 4-13 15378764-4 2004 The ovalbumin-induced degradation of annexin-1 was blocked by pretreatment of mice with the antioxidant N-acetylcysteine (NAC) or with sodium selenite, both of which have previously been shown to exert anti-inflammatory effects in this asthma model. Sodium Selenite 135-150 annexin A1 Mus musculus 37-46 15695848-1 2005 The effect of 0.05, 0.1, and 0.2 mg sodium selenite/kg body weight ip on the activities of neurobehavioral, acetyl cholinesterase, monoamine oxidase, and the content of dopamine and its metabolites in circadian rhythm centers of male Wistar rats was studied after 7 d of treatment. Sodium Selenite 36-51 acetylcholinesterase Rattus norvegicus 91-129 15695848-4 2005 The activity of acetylcholinesterase (AChE) was inhibited dose dependently, and it was significant in preoptic area with 0.1 or 0.2 mg sodium selenite/kg. Sodium Selenite 135-150 acetylcholinesterase Rattus norvegicus 16-36 15695848-4 2005 The activity of acetylcholinesterase (AChE) was inhibited dose dependently, and it was significant in preoptic area with 0.1 or 0.2 mg sodium selenite/kg. Sodium Selenite 135-150 acetylcholinesterase Rattus norvegicus 38-42 15695848-6 2005 Monoamine oxidase (MAO) activity was increased in preoptic area with the dose of 0.1 mg sodium selenite/kg, but its alteration in posterior hypothalamus and brain stem was not significant. Sodium Selenite 88-103 monoamine oxidase A Rattus norvegicus 0-17 15695848-6 2005 Monoamine oxidase (MAO) activity was increased in preoptic area with the dose of 0.1 mg sodium selenite/kg, but its alteration in posterior hypothalamus and brain stem was not significant. Sodium Selenite 88-103 monoamine oxidase A Rattus norvegicus 19-22 15748481-8 2004 0.75, 1.50 and 3.00 mg/kg of sodium selenite presented antagonistic effects against DNA damage induced by 250 mg/kg of BaP in mouse"s lung cells. Sodium Selenite 29-44 prohibitin 2 Mus musculus 119-122 15748481-11 2004 0.75 approximately 3.00 mg/kg of sodium selenite could inhibit DNA damage of lung cells in mice induced by 250 mg/kg of BaP. Sodium Selenite 33-48 prohibitin 2 Mus musculus 120-123 15480664-4 2004 In this study, we demonstrated that sodium selenite could induce apoptosis in NB4 cells via the classic mitochondrial pathway involving caspase-3 activation and Bcl-2 cleavage. Sodium Selenite 36-51 caspase 3 Homo sapiens 136-145 15480664-4 2004 In this study, we demonstrated that sodium selenite could induce apoptosis in NB4 cells via the classic mitochondrial pathway involving caspase-3 activation and Bcl-2 cleavage. Sodium Selenite 36-51 BCL2 apoptosis regulator Homo sapiens 161-166 15130278-5 2004 MnSOD-overexpressing cells showed an increase in sensitivity to the cytotoxicity of buthionine sulfoximine, a glutathione-depleting agent, and vitamin C, but a decrease in sensitivity to sodium selenite. Sodium Selenite 187-202 superoxide dismutase 2 Homo sapiens 0-5 15248187-1 2004 The anticarcinogenic/antioxidant potential of sodium selenite (Se), a micronutrient, was evaluated on liver tumourigenesis induced by N-nitrosodiethylamine (DEN) and promoted by phenobarbital (PB; 0.05% in diet). Sodium Selenite 46-61 dendrin Rattus norvegicus 157-160 15135304-1 2004 Selenium compounds, such as sodium selenite and Ebselen were shown to increase high affinity ryanodine binding to the skeletal muscle type ryanodine receptor (RyR1) at nanomolar concentrations, and inhibit the receptor at low micromolar concentrations. Sodium Selenite 28-43 ryanodine receptor 1 Oryctolagus cuniculus 118-157 15135304-1 2004 Selenium compounds, such as sodium selenite and Ebselen were shown to increase high affinity ryanodine binding to the skeletal muscle type ryanodine receptor (RyR1) at nanomolar concentrations, and inhibit the receptor at low micromolar concentrations. Sodium Selenite 28-43 ryanodine receptor 1 Oryctolagus cuniculus 159-163 15135304-5 2004 Sodium selenite and Ebselen stimulated the skeletal muscle ryanodine receptor by oxidizing 14 of 47 free thiols per monomer on RyR1 (as detected with the alkylating agent 7-diethylamino-3-(4"-maleimidylphenyl)-4-methylcoumarin) (CPM). Sodium Selenite 0-15 ryanodine receptor 1 Oryctolagus cuniculus 43-77 15135304-5 2004 Sodium selenite and Ebselen stimulated the skeletal muscle ryanodine receptor by oxidizing 14 of 47 free thiols per monomer on RyR1 (as detected with the alkylating agent 7-diethylamino-3-(4"-maleimidylphenyl)-4-methylcoumarin) (CPM). Sodium Selenite 0-15 ryanodine receptor 1 Oryctolagus cuniculus 127-131 15274301-9 2004 By contrast sodium selenite caused phosphorylation of p53 serines 20, 37 and 46 known to mediate apoptosis. Sodium Selenite 12-27 tumor protein p53 Homo sapiens 54-57 15118998-4 2004 The TrxR activities in both Chang and HepG2 cell lines were similarly induced by treatment with sodium selenite (0.02 mM) and menadione (0.5 and 1.0 mM). Sodium Selenite 96-111 peroxiredoxin 5 Homo sapiens 4-8 14737004-0 2004 Sodium selenite-induced apoptosis in murine B-lymphoma cells is associated with inhibition of protein kinase C-delta, nuclear factor kappaB, and inhibitor of apoptosis protein. Sodium Selenite 0-15 magnesium transporter 1 Mus musculus 145-175 15157320-0 2004 [The effect of all-trans retinoid acid and sodium selenite (Na2SeO3) on VEGF and its receptor expression in HL-60 cells]. Sodium Selenite 43-58 vascular endothelial growth factor A Homo sapiens 72-76 15157320-1 2004 In order to investigate the effect of non-medullar toxicity drug - all trans retinoid acid (ATRA) and cancer preventive trace element-selenium compound - sodium selenite (Na(2)SeO(3)) on the expression of vascular endothelial growth factor (VEGF) and its receptor in HL-60 cells, the expression of VEGF and its receptor in HL-60 cells were detected by ELISA technique and flow cytometry before and after treatment with two drugs. Sodium Selenite 154-169 vascular endothelial growth factor A Homo sapiens 205-239 14657013-5 2004 BIG-3 protein levels increased during ITS (insulin, transferrin, sodium selenite)-induced ATDC5 differentiation and in response to BMP-2 treatment. Sodium Selenite 65-80 WD repeat domain 5 Mus musculus 0-5 14642406-4 2003 In human umbilical vein endothelial cells (HUVEC), GPx4 mRNA levels and activity were increased optimally by 114 nM selenium (as sodium selenite). Sodium Selenite 129-144 glutathione peroxidase 4 Homo sapiens 51-55 12808288-5 2003 The specific activity (unit per pmol of selenium) of selenoprotein P fragments protein was 15-fold and 1900-fold higher than that of the full-length SeP and sodium selenite, respectively. Sodium Selenite 157-172 selenoprotein P Homo sapiens 53-68