PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20127426-5	2011	Dynamical imaging showed that curcumol induced a rapid translocation of Bax from cytosol into mitochondria within 6 h, leading to a rapid dissipation of mitochondrial membrane potential ( Psim), implying that mitochondria play an important role in the curcumol-induced apoptosis.	curcumol	30-38	BCL2 associated X, apoptosis regulator	Homo sapiens	72-75
20127426-5	2011	Dynamical imaging showed that curcumol induced a rapid translocation of Bax from cytosol into mitochondria within 6 h, leading to a rapid dissipation of mitochondrial membrane potential ( Psim), implying that mitochondria play an important role in the curcumol-induced apoptosis.	curcumol	252-260	BCL2 associated X, apoptosis regulator	Homo sapiens	72-75
16425384-11	2005	Moreover, after HSC-T6 cells were cultured in a medium containing 1.5625 microg/mL of Curcumol for 12 h, the expression of TGFbeta1 and P450a decreased 2.3- and 2.1-folds, respectively.	curcumol	86-94	transforming growth factor, beta 1	Rattus norvegicus	123-131
34265379-0	2021	Histone methylatic modification mediates the tumor-suppressive activity of curcumol in hepatocellular carcinoma via an Hotair/EZH2 regulatory axis.	curcumol	75-83	HOX transcript antisense RNA	Homo sapiens	119-125
34750896-7	2021	In this study, we found that curcumol induced autophagy through AMPK/mTOR pathway in CNE-2 cells.	curcumol	29-37	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	64-68
34750896-7	2021	In this study, we found that curcumol induced autophagy through AMPK/mTOR pathway in CNE-2 cells.	curcumol	29-37	mechanistic target of rapamycin kinase	Homo sapiens	69-73
34750896-10	2021	Taken together, our study demonstrates that curcumol promotes autophagy in NPC via AMPK/mTOR pathway, induces autophagy enhances the activity of curcumol in NPC cells; the combination of autophagy inducer and curcumol can be a new therapeutic strategy for NPC.	curcumol	44-52	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	83-87
34750896-10	2021	Taken together, our study demonstrates that curcumol promotes autophagy in NPC via AMPK/mTOR pathway, induces autophagy enhances the activity of curcumol in NPC cells; the combination of autophagy inducer and curcumol can be a new therapeutic strategy for NPC.	curcumol	44-52	mechanistic target of rapamycin kinase	Homo sapiens	88-92
34265379-0	2021	Histone methylatic modification mediates the tumor-suppressive activity of curcumol in hepatocellular carcinoma via an Hotair/EZH2 regulatory axis.	curcumol	75-83	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	126-130
34265379-10	2021	As for the mechanism investigation, it was showed that lncRNA Hotair was significantly downregulated by Curcumol in HCC cells.	curcumol	104-112	HOX transcript antisense RNA	Homo sapiens	62-68
34265379-12	2021	Our results showed that EZH2 were downregulated by Curcumol in HCC cells, and thus disrupted the trimethylation of H3K9 and H3K27 which were specifically catalyzed by EZH2.	curcumol	51-59	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	24-28
34265379-12	2021	Our results showed that EZH2 were downregulated by Curcumol in HCC cells, and thus disrupted the trimethylation of H3K9 and H3K27 which were specifically catalyzed by EZH2.	curcumol	51-59	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	167-171
34265379-13	2021	CONCLUSIONS: In conclude, our results demonstrated that Curcumol suppressed tumor growth and metastasis via an Hotair/EZH2/histone modification regulatory axis.	curcumol	56-64	HOX transcript antisense RNA	Homo sapiens	111-117
34265379-13	2021	CONCLUSIONS: In conclude, our results demonstrated that Curcumol suppressed tumor growth and metastasis via an Hotair/EZH2/histone modification regulatory axis.	curcumol	56-64	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	118-122
34428442-0	2021	Curcumol inhibits EBV-positive Nasopharyngeal carcinoma migration and invasion by targeting nucleolin.	curcumol	0-8	nucleolin	Homo sapiens	92-101
34590156-0	2021	Curcumol inhibits the malignant progression of prostate cancer and regulates the PDK1/AKT/mTOR pathway by targeting miR-9.	curcumol	0-8	pyruvate dehydrogenase kinase 1	Homo sapiens	81-85
34590156-0	2021	Curcumol inhibits the malignant progression of prostate cancer and regulates the PDK1/AKT/mTOR pathway by targeting miR-9.	curcumol	0-8	AKT serine/threonine kinase 1	Homo sapiens	86-89
34590156-0	2021	Curcumol inhibits the malignant progression of prostate cancer and regulates the PDK1/AKT/mTOR pathway by targeting miR-9.	curcumol	0-8	mechanistic target of rapamycin kinase	Homo sapiens	90-94
34590156-6	2021	After PC3 cells were transfected with miR-9 inhibitor or treated with curcumol, the expression levels of the PDK1/AKT/mTOR signaling pathway-related proteins (PDK1, phosphorylated (p)-AKT and p-mTOR) were increased or decreased, respectively.	curcumol	70-78	pyruvate dehydrogenase kinase 1	Homo sapiens	109-113
34590156-6	2021	After PC3 cells were transfected with miR-9 inhibitor or treated with curcumol, the expression levels of the PDK1/AKT/mTOR signaling pathway-related proteins (PDK1, phosphorylated (p)-AKT and p-mTOR) were increased or decreased, respectively.	curcumol	70-78	AKT serine/threonine kinase 1	Homo sapiens	114-117
34590156-6	2021	After PC3 cells were transfected with miR-9 inhibitor or treated with curcumol, the expression levels of the PDK1/AKT/mTOR signaling pathway-related proteins (PDK1, phosphorylated (p)-AKT and p-mTOR) were increased or decreased, respectively.	curcumol	70-78	mechanistic target of rapamycin kinase	Homo sapiens	118-122
34590156-6	2021	After PC3 cells were transfected with miR-9 inhibitor or treated with curcumol, the expression levels of the PDK1/AKT/mTOR signaling pathway-related proteins (PDK1, phosphorylated (p)-AKT and p-mTOR) were increased or decreased, respectively.	curcumol	70-78	pyruvate dehydrogenase kinase 1	Homo sapiens	159-163
34590156-6	2021	After PC3 cells were transfected with miR-9 inhibitor or treated with curcumol, the expression levels of the PDK1/AKT/mTOR signaling pathway-related proteins (PDK1, phosphorylated (p)-AKT and p-mTOR) were increased or decreased, respectively.	curcumol	70-78	AKT serine/threonine kinase 1	Homo sapiens	184-187
34590156-6	2021	After PC3 cells were transfected with miR-9 inhibitor or treated with curcumol, the expression levels of the PDK1/AKT/mTOR signaling pathway-related proteins (PDK1, phosphorylated (p)-AKT and p-mTOR) were increased or decreased, respectively.	curcumol	70-78	mechanistic target of rapamycin kinase	Homo sapiens	194-198
34590156-8	2021	Tumor size and the expression levels of PDK1/AKT/mTOR signaling pathway-related factors were altered following treatment with curcumol.	curcumol	126-134	pyruvate dehydrogenase kinase 1	Homo sapiens	40-44
34590156-8	2021	Tumor size and the expression levels of PDK1/AKT/mTOR signaling pathway-related factors were altered following treatment with curcumol.	curcumol	126-134	AKT serine/threonine kinase 1	Homo sapiens	45-48
34590156-8	2021	Tumor size and the expression levels of PDK1/AKT/mTOR signaling pathway-related factors were altered following treatment with curcumol.	curcumol	126-134	mechanistic target of rapamycin kinase	Homo sapiens	49-53
34590156-9	2021	The in vitro and in vivo experiments collectively demonstrated that curcumol could inhibit the PDK1/AKT/mTOR signaling pathway by upregulating the expression level of miR-9.	curcumol	68-76	pyruvate dehydrogenase kinase 1	Homo sapiens	95-99
34590156-9	2021	The in vitro and in vivo experiments collectively demonstrated that curcumol could inhibit the PDK1/AKT/mTOR signaling pathway by upregulating the expression level of miR-9.	curcumol	68-76	AKT serine/threonine kinase 1	Homo sapiens	100-103
34590156-9	2021	The in vitro and in vivo experiments collectively demonstrated that curcumol could inhibit the PDK1/AKT/mTOR signaling pathway by upregulating the expression level of miR-9.	curcumol	68-76	mechanistic target of rapamycin kinase	Homo sapiens	104-108
34590156-10	2021	The present study found that curcumol regulates the PDK1/AKT/mTOR signaling pathway via miR-9 and affects the development of prostate cancer.	curcumol	29-37	pyruvate dehydrogenase kinase 1	Homo sapiens	52-56
34590156-10	2021	The present study found that curcumol regulates the PDK1/AKT/mTOR signaling pathway via miR-9 and affects the development of prostate cancer.	curcumol	29-37	AKT serine/threonine kinase 1	Homo sapiens	57-60
34590156-10	2021	The present study found that curcumol regulates the PDK1/AKT/mTOR signaling pathway via miR-9 and affects the development of prostate cancer.	curcumol	29-37	mechanistic target of rapamycin kinase	Homo sapiens	61-65
34450323-0	2021	Curcumol Alleviates the Inflammation of Nucleus Pulposus Cells via the PI3K/Akt/NF-kappaB Signaling Pathway and Delays Intervertebral Disc Degeneration.	curcumol	0-8	thymoma viral proto-oncogene 1	Mus musculus	76-79
34450323-0	2021	Curcumol Alleviates the Inflammation of Nucleus Pulposus Cells via the PI3K/Akt/NF-kappaB Signaling Pathway and Delays Intervertebral Disc Degeneration.	curcumol	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	80-89
34450323-3	2021	In this study, we sought to determine the mechanism of curcumol in TNF-alpha-induced nucleus pulposus cells (NPCs) and a mouse IVDD model.	curcumol	55-63	tumor necrosis factor	Mus musculus	67-76
34450323-9	2021	RESULTS: Curcumol reduced IL-1beta, IL-6 and TNF-alpha production in NPCs, and the phosphorylation of proteins in the PI3K/Akt/NF-kappaB signaling pathway was also decreased.	curcumol	9-17	interleukin 1 alpha	Mus musculus	26-34
34450323-9	2021	RESULTS: Curcumol reduced IL-1beta, IL-6 and TNF-alpha production in NPCs, and the phosphorylation of proteins in the PI3K/Akt/NF-kappaB signaling pathway was also decreased.	curcumol	9-17	interleukin 6	Mus musculus	36-40
34450323-9	2021	RESULTS: Curcumol reduced IL-1beta, IL-6 and TNF-alpha production in NPCs, and the phosphorylation of proteins in the PI3K/Akt/NF-kappaB signaling pathway was also decreased.	curcumol	9-17	tumor necrosis factor	Mus musculus	45-54
34450323-9	2021	RESULTS: Curcumol reduced IL-1beta, IL-6 and TNF-alpha production in NPCs, and the phosphorylation of proteins in the PI3K/Akt/NF-kappaB signaling pathway was also decreased.	curcumol	9-17	thymoma viral proto-oncogene 1	Mus musculus	123-126
34450323-9	2021	RESULTS: Curcumol reduced IL-1beta, IL-6 and TNF-alpha production in NPCs, and the phosphorylation of proteins in the PI3K/Akt/NF-kappaB signaling pathway was also decreased.	curcumol	9-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	127-136
34450323-12	2021	CONCLUSION: These results suggest a potential therapeutic use of curcumol to alleviate inflammation via the PI3K/Akt/NF-kappaB signaling pathway and delay the progression of IVDD.	curcumol	65-73	thymoma viral proto-oncogene 1	Mus musculus	113-116
34450323-12	2021	CONCLUSION: These results suggest a potential therapeutic use of curcumol to alleviate inflammation via the PI3K/Akt/NF-kappaB signaling pathway and delay the progression of IVDD.	curcumol	65-73	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	117-126
34428442-5	2021	Moreover, further study showed that the differential expression of NCL and curcumol intervention only had a regulatory effect on the nuclear accumulation of VEGFR1, which strengthened the anti-cancer effect of curcumol mediated through NCL.	curcumol	75-83	fms related receptor tyrosine kinase 1	Homo sapiens	157-163
34428442-5	2021	Moreover, further study showed that the differential expression of NCL and curcumol intervention only had a regulatory effect on the nuclear accumulation of VEGFR1, which strengthened the anti-cancer effect of curcumol mediated through NCL.	curcumol	210-218	fms related receptor tyrosine kinase 1	Homo sapiens	157-163
34428442-6	2021	Our findings indicated that curcumol exerted anti EBV-positive NPC invasion and metastasis by downregulating EBNA1 and inhibiting VEGFA/VEGFR1/PI3K/AKT signaling by targeting NCL, which provides a novel pharmacological basis for curcumol"s clinical use in treating patients with EBV-positive NPC.	curcumol	28-36	vascular endothelial growth factor A	Homo sapiens	130-135
34428442-6	2021	Our findings indicated that curcumol exerted anti EBV-positive NPC invasion and metastasis by downregulating EBNA1 and inhibiting VEGFA/VEGFR1/PI3K/AKT signaling by targeting NCL, which provides a novel pharmacological basis for curcumol"s clinical use in treating patients with EBV-positive NPC.	curcumol	28-36	fms related receptor tyrosine kinase 1	Homo sapiens	136-142
34428442-6	2021	Our findings indicated that curcumol exerted anti EBV-positive NPC invasion and metastasis by downregulating EBNA1 and inhibiting VEGFA/VEGFR1/PI3K/AKT signaling by targeting NCL, which provides a novel pharmacological basis for curcumol"s clinical use in treating patients with EBV-positive NPC.	curcumol	28-36	AKT serine/threonine kinase 1	Homo sapiens	148-151
34428442-6	2021	Our findings indicated that curcumol exerted anti EBV-positive NPC invasion and metastasis by downregulating EBNA1 and inhibiting VEGFA/VEGFR1/PI3K/AKT signaling by targeting NCL, which provides a novel pharmacological basis for curcumol"s clinical use in treating patients with EBV-positive NPC.	curcumol	229-237	vascular endothelial growth factor A	Homo sapiens	130-135
34587973-0	2021	Curcumol inhibits encephalomyocarditis virus by promoting IFN-beta secretion.	curcumol	0-8	IFN1@	Homo sapiens	58-66
34587973-8	2021	The effect of curcumol on the expression of IFN-beta was investigated using real-time quantitative PCR and ELISA.	curcumol	14-22	IFN1@	Homo sapiens	44-52
34587973-12	2021	The curcumol (0.025 mg/mL) treatment has significantly increased IFN-beta mRNA expression in the EMCV-infected HEK-293 T cells while ribavirin treatment did not.	curcumol	4-12	IFN1@	Homo sapiens	65-73
34587973-13	2021	The results of ELISA showed that curcumol (0.025 mg/mL and 0.0125 mg/mL) has significantly increased the expression of IFN-beta protein in EMCV-infected HEK-293 T cells.	curcumol	33-41	IFN1@	Homo sapiens	119-127
34587973-14	2021	The results of Western blot showed that curcumol can inhibit the degradation of TANK protein mediated by EMCV and promote the expression of MDA5 and P-IRF3, while the protein expression level of MAVS and IRF3 remain unchanged.	curcumol	40-48	interferon induced with helicase C domain 1	Homo sapiens	140-144
34587973-14	2021	The results of Western blot showed that curcumol can inhibit the degradation of TANK protein mediated by EMCV and promote the expression of MDA5 and P-IRF3, while the protein expression level of MAVS and IRF3 remain unchanged.	curcumol	40-48	interferon regulatory factor 3	Homo sapiens	151-155
34587973-15	2021	CONCLUSION: Curcumol has biological activity against EMCV which we suggest that IFN-beta signaling pathway is one of its mechanisms.	curcumol	12-20	IFN1@	Homo sapiens	80-88
35582617-0	2022	Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.	curcumol	0-8	sirtuin 1	Mus musculus	131-136
34346124-7	2021	Moreover, overexpression of nuclear receptor coactivator 4 (NCOA4) weakened the effect of curcumol on ferritinophagy-mediated iron overload and cellular senescence.	curcumol	90-98	nuclear receptor coactivator 4	Homo sapiens	28-58
34346124-7	2021	Moreover, overexpression of nuclear receptor coactivator 4 (NCOA4) weakened the effect of curcumol on ferritinophagy-mediated iron overload and cellular senescence.	curcumol	90-98	nuclear receptor coactivator 4	Homo sapiens	60-65
34346124-8	2021	Furthermore, we demonstrated that curcumol reduced the expression of NCOA4 by Yes-associated protein (YAP).	curcumol	34-42	nuclear receptor coactivator 4	Homo sapiens	69-74
34346124-8	2021	Furthermore, we demonstrated that curcumol reduced the expression of NCOA4 by Yes-associated protein (YAP).	curcumol	34-42	Yes1 associated transcriptional regulator	Homo sapiens	78-100
34346124-8	2021	Furthermore, we demonstrated that curcumol reduced the expression of NCOA4 by Yes-associated protein (YAP).	curcumol	34-42	Yes1 associated transcriptional regulator	Homo sapiens	102-105
34346124-9	2021	In addition, depression of YAP could impair the effect of curcumol on iron overload and cellular senescence.	curcumol	58-66	Yes1 associated transcriptional regulator	Homo sapiens	27-30
34346124-10	2021	CONCLUSION: Our results clarified the mechanism of curcumol inhibition of hepatocyte senescence through YAP/NCOA4 regulation of ferritinophagy in NAFLD.	curcumol	51-59	Yes1 associated transcriptional regulator	Homo sapiens	104-107
34346124-10	2021	CONCLUSION: Our results clarified the mechanism of curcumol inhibition of hepatocyte senescence through YAP/NCOA4 regulation of ferritinophagy in NAFLD.	curcumol	51-59	nuclear receptor coactivator 4	Homo sapiens	108-113
34346124-11	2021	These findings provided a promising option of curcumol to regulate cellular senescence by target YAP/NCOA4 for the treatment of NAFLD.	curcumol	46-54	Yes1 associated transcriptional regulator	Homo sapiens	97-100
34346124-11	2021	These findings provided a promising option of curcumol to regulate cellular senescence by target YAP/NCOA4 for the treatment of NAFLD.	curcumol	46-54	nuclear receptor coactivator 4	Homo sapiens	101-106
34319504-0	2021	Effect of Curcumol on NOD-Like Receptor Thermoprotein Domain 3 Inflammasomes in Liver Fibrosis of Mice.	curcumol	10-18	NLR family, pyrin domain containing 3	Mus musculus	22-62
34319504-1	2021	OBJECTIVE: To investigate the effect of curcumol on NOD-like receptor thermoprotein domain 3 (NLRP3) inflammasomes, and analyze the mechanism underlying curcumol against liver fibrosis.	curcumol	40-48	NLR family, pyrin domain containing 3	Mus musculus	52-92
34319504-1	2021	OBJECTIVE: To investigate the effect of curcumol on NOD-like receptor thermoprotein domain 3 (NLRP3) inflammasomes, and analyze the mechanism underlying curcumol against liver fibrosis.	curcumol	40-48	NLR family, pyrin domain containing 3	Mus musculus	94-99
34319504-11	2021	CONCLUSION: A potential anti-liver fibrosis mechanism of curcumol may be associated with the inhibition of NLRP3 inflammasomes and decreasing the downstream inflammatory response.	curcumol	57-65	NLR family, pyrin domain containing 3	Mus musculus	107-112
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	collagen type III alpha 1 chain	Homo sapiens	179-185
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	actin alpha 1, skeletal muscle	Homo sapiens	190-199
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	mitogen-activated protein kinase 1	Homo sapiens	225-228
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	mitogen-activated protein kinase 3	Homo sapiens	258-264
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	mitogen-activated protein kinase kinase 7	Homo sapiens	268-271
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	278-283
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	BCL2 associated X, apoptosis regulator	Homo sapiens	318-321
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	caspase 3	Homo sapiens	334-343
34134955-6	2021	Curcumol treatment at 160 mg/L obviously inhibited the proliferation and collagen synthesis, promoted cell apoptosis and inhibited the ERK signaling pathway in the keloid fibroblasts; treatment with ISO significantly reversed the effects of curcumol on the proliferation, apoptosis, collagen synthesis and ERK signal pathway of the cells.	curcumol	0-8	mitogen-activated protein kinase 1	Homo sapiens	135-138
34134955-6	2021	Curcumol treatment at 160 mg/L obviously inhibited the proliferation and collagen synthesis, promoted cell apoptosis and inhibited the ERK signaling pathway in the keloid fibroblasts; treatment with ISO significantly reversed the effects of curcumol on the proliferation, apoptosis, collagen synthesis and ERK signal pathway of the cells.	curcumol	0-8	mitogen-activated protein kinase 1	Homo sapiens	306-309
34134955-6	2021	Curcumol treatment at 160 mg/L obviously inhibited the proliferation and collagen synthesis, promoted cell apoptosis and inhibited the ERK signaling pathway in the keloid fibroblasts; treatment with ISO significantly reversed the effects of curcumol on the proliferation, apoptosis, collagen synthesis and ERK signal pathway of the cells.	curcumol	241-249	mitogen-activated protein kinase 1	Homo sapiens	306-309
34134955-7	2021	OBJECTIVE: Curcumol regulates proliferation, apoptosis and collagen synthesis in keloid fibroblasts through the ERK signaling pathway.	curcumol	11-19	mitogen-activated protein kinase 1	Homo sapiens	112-115
34346124-0	2021	Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease.	curcumol	0-8	Yes1 associated transcriptional regulator	Homo sapiens	75-78
34346124-0	2021	Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease.	curcumol	0-8	nuclear receptor coactivator 4	Homo sapiens	79-84
34314383-0	2021	Curcumol may alleviate psoriasis-like inflammation by inhibiting keratinocyte proliferation and inflammatory gene expression via JAK1/STAT3 signaling.	curcumol	0-8	Janus kinase 1	Homo sapiens	129-133
34314383-0	2021	Curcumol may alleviate psoriasis-like inflammation by inhibiting keratinocyte proliferation and inflammatory gene expression via JAK1/STAT3 signaling.	curcumol	0-8	signal transducer and activator of transcription 3	Homo sapiens	134-139
34314383-3	2021	Our data show that curcumol significantly inhibits proliferation and induces cell cycle arrest in NHEK cells stimulated with proinflammatory cytokines (IL-1alpha, IL-17A, IL-22, oncostatin M, and TNF-alpha; mix M5).	curcumol	19-27	interleukin 1 alpha	Homo sapiens	152-161
34314383-3	2021	Our data show that curcumol significantly inhibits proliferation and induces cell cycle arrest in NHEK cells stimulated with proinflammatory cytokines (IL-1alpha, IL-17A, IL-22, oncostatin M, and TNF-alpha; mix M5).	curcumol	19-27	interleukin 17A	Homo sapiens	163-169
34314383-3	2021	Our data show that curcumol significantly inhibits proliferation and induces cell cycle arrest in NHEK cells stimulated with proinflammatory cytokines (IL-1alpha, IL-17A, IL-22, oncostatin M, and TNF-alpha; mix M5).	curcumol	19-27	interleukin 22	Homo sapiens	171-176
34314383-3	2021	Our data show that curcumol significantly inhibits proliferation and induces cell cycle arrest in NHEK cells stimulated with proinflammatory cytokines (IL-1alpha, IL-17A, IL-22, oncostatin M, and TNF-alpha; mix M5).	curcumol	19-27	oncostatin M	Homo sapiens	178-190
34314383-5	2021	Curcumol inhibits activity of JAK1, resulting in the inhibition of STAT3, downregulation of cyclin D2, and cell cycle arrest in stimulated NHEK cells.	curcumol	0-8	Janus kinase 1	Homo sapiens	30-34
34314383-5	2021	Curcumol inhibits activity of JAK1, resulting in the inhibition of STAT3, downregulation of cyclin D2, and cell cycle arrest in stimulated NHEK cells.	curcumol	0-8	signal transducer and activator of transcription 3	Homo sapiens	67-72
34314383-5	2021	Curcumol inhibits activity of JAK1, resulting in the inhibition of STAT3, downregulation of cyclin D2, and cell cycle arrest in stimulated NHEK cells.	curcumol	0-8	cyclin D2	Homo sapiens	92-101
34314383-6	2021	Together, our data show that curcumol reduces proliferation and inflammatory gene expression in stimulated keratinocytes by inhibiting the JAK1/STAT3 signaling, suggesting that it might serve as a potential therapeutic option for the treatment of psoriasis.	curcumol	29-37	Janus kinase 1	Homo sapiens	139-143
34314383-6	2021	Together, our data show that curcumol reduces proliferation and inflammatory gene expression in stimulated keratinocytes by inhibiting the JAK1/STAT3 signaling, suggesting that it might serve as a potential therapeutic option for the treatment of psoriasis.	curcumol	29-37	signal transducer and activator of transcription 3	Homo sapiens	144-149
34188444-0	2021	Curcumol Ameliorates Lung Inflammation and Airway Remodeling via Inhibiting the Abnormal Activation of the Wnt/beta-Catenin Pathway in Chronic Asthmatic Mice.	curcumol	0-8	wingless-type MMTV integration site family, member 5A	Mus musculus	107-110
34188444-0	2021	Curcumol Ameliorates Lung Inflammation and Airway Remodeling via Inhibiting the Abnormal Activation of the Wnt/beta-Catenin Pathway in Chronic Asthmatic Mice.	curcumol	0-8	catenin (cadherin associated protein), beta 1	Mus musculus	111-123
34188444-10	2021	Curcumol relieved collagen deposition in airway tissues, inflammation cell recruitment in BALF, and reduced the up-regulation of serum ovalbumin-IgE, IL-4, IL-5, and IL-13 and BALF VEGFA in chronic asthmatic mice.	curcumol	0-8	interleukin 4	Mus musculus	150-154
34188444-10	2021	Curcumol relieved collagen deposition in airway tissues, inflammation cell recruitment in BALF, and reduced the up-regulation of serum ovalbumin-IgE, IL-4, IL-5, and IL-13 and BALF VEGFA in chronic asthmatic mice.	curcumol	0-8	interleukin 5	Mus musculus	156-160
34188444-10	2021	Curcumol relieved collagen deposition in airway tissues, inflammation cell recruitment in BALF, and reduced the up-regulation of serum ovalbumin-IgE, IL-4, IL-5, and IL-13 and BALF VEGFA in chronic asthmatic mice.	curcumol	0-8	interleukin 13	Mus musculus	166-171
34188444-10	2021	Curcumol relieved collagen deposition in airway tissues, inflammation cell recruitment in BALF, and reduced the up-regulation of serum ovalbumin-IgE, IL-4, IL-5, and IL-13 and BALF VEGFA in chronic asthmatic mice.	curcumol	0-8	vascular endothelial growth factor A	Mus musculus	181-186
34188444-11	2021	In addition, curcumol attenuated the up-regulated expressions of beta-catenin, Wnt5a, VEGFA, TGF-beta1, Fibronectin, and MMP-9 in the lung tissues of chronic asthmatic mice, but curcumol treatment did not show such effects on healthy mice.	curcumol	13-21	catenin (cadherin associated protein), beta 1	Mus musculus	65-77
34188444-11	2021	In addition, curcumol attenuated the up-regulated expressions of beta-catenin, Wnt5a, VEGFA, TGF-beta1, Fibronectin, and MMP-9 in the lung tissues of chronic asthmatic mice, but curcumol treatment did not show such effects on healthy mice.	curcumol	13-21	wingless-type MMTV integration site family, member 5A	Mus musculus	79-84
34188444-11	2021	In addition, curcumol attenuated the up-regulated expressions of beta-catenin, Wnt5a, VEGFA, TGF-beta1, Fibronectin, and MMP-9 in the lung tissues of chronic asthmatic mice, but curcumol treatment did not show such effects on healthy mice.	curcumol	13-21	vascular endothelial growth factor A	Mus musculus	86-91
34188444-11	2021	In addition, curcumol attenuated the up-regulated expressions of beta-catenin, Wnt5a, VEGFA, TGF-beta1, Fibronectin, and MMP-9 in the lung tissues of chronic asthmatic mice, but curcumol treatment did not show such effects on healthy mice.	curcumol	13-21	transforming growth factor, beta 1	Mus musculus	93-102
34188444-11	2021	In addition, curcumol attenuated the up-regulated expressions of beta-catenin, Wnt5a, VEGFA, TGF-beta1, Fibronectin, and MMP-9 in the lung tissues of chronic asthmatic mice, but curcumol treatment did not show such effects on healthy mice.	curcumol	13-21	fibronectin 1	Mus musculus	104-115
34188444-11	2021	In addition, curcumol attenuated the up-regulated expressions of beta-catenin, Wnt5a, VEGFA, TGF-beta1, Fibronectin, and MMP-9 in the lung tissues of chronic asthmatic mice, but curcumol treatment did not show such effects on healthy mice.	curcumol	13-21	matrix metallopeptidase 9	Mus musculus	121-126
34188444-12	2021	Conclusion: Our findings revealed that curcumol could ameliorate lung inflammation and airway remodeling by inhibiting the abnormal activation of the Wnt/beta-catenin pathway in chronic asthmatic mice, indicating that curcumol could be used as a novel anti-asthma drug for basic and clinical research.	curcumol	39-47	wingless-type MMTV integration site family, member 5A	Mus musculus	150-153
34188444-12	2021	Conclusion: Our findings revealed that curcumol could ameliorate lung inflammation and airway remodeling by inhibiting the abnormal activation of the Wnt/beta-catenin pathway in chronic asthmatic mice, indicating that curcumol could be used as a novel anti-asthma drug for basic and clinical research.	curcumol	39-47	catenin (cadherin associated protein), beta 1	Mus musculus	154-166
34188444-12	2021	Conclusion: Our findings revealed that curcumol could ameliorate lung inflammation and airway remodeling by inhibiting the abnormal activation of the Wnt/beta-catenin pathway in chronic asthmatic mice, indicating that curcumol could be used as a novel anti-asthma drug for basic and clinical research.	curcumol	218-226	wingless-type MMTV integration site family, member 5A	Mus musculus	150-153
34188444-12	2021	Conclusion: Our findings revealed that curcumol could ameliorate lung inflammation and airway remodeling by inhibiting the abnormal activation of the Wnt/beta-catenin pathway in chronic asthmatic mice, indicating that curcumol could be used as a novel anti-asthma drug for basic and clinical research.	curcumol	218-226	catenin (cadherin associated protein), beta 1	Mus musculus	154-166
34134955-0	2021	(Curcumol inhibits keloid fibroblast proliferation and collagen synthesis through the ERK signaling pathway).	curcumol	1-9	mitogen-activated protein kinase 1	Homo sapiens	86-89
34134955-2	2021	OBJECTIVE: Keloid fibroblasts were treated with different concentrations of curcumol (10, 20, 40, 80 and 160 mg/L) or with 160 mg/L curcumol and 20 mumol/L ISO (an ERK signaling pathway activator).	curcumol	132-140	mitogen-activated protein kinase 1	Homo sapiens	164-167
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	cyclin D1	Homo sapiens	90-99
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	proliferating cell nuclear antigen	Homo sapiens	101-105
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	BCL2 apoptosis regulator	Homo sapiens	110-115
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	collagen type I alpha 1 chain	Homo sapiens	171-177
35253605-0	2022	Curcumol inhibits the growth of xenograft-tumors in mice and the biological activities of pancreatic cancer cells by regulating the miR-21-5p/SMAD7 axis.	curcumol	0-8	microRNA 215	Mus musculus	132-141
35253605-0	2022	Curcumol inhibits the growth of xenograft-tumors in mice and the biological activities of pancreatic cancer cells by regulating the miR-21-5p/SMAD7 axis.	curcumol	0-8	SMAD family member 7	Mus musculus	142-147
35253605-11	2022	Curcumol inhibited the xenograft-tumor size, tumor weight, and PCNA and miR-21-5p expressions while promoting Cleaved caspase-3 expression in xenograft-tumor tissues.	curcumol	0-8	proliferating cell nuclear antigen	Mus musculus	63-67
35253605-11	2022	Curcumol inhibited the xenograft-tumor size, tumor weight, and PCNA and miR-21-5p expressions while promoting Cleaved caspase-3 expression in xenograft-tumor tissues.	curcumol	0-8	microRNA 21	Homo sapiens	72-78
35253605-12	2022	Curcumol inhibited the viability, proliferation, migration, invasion, and miR-21-5p expression, but increased SMAD7 expression in cancer cells.	curcumol	0-8	microRNA 215	Mus musculus	74-83
35253605-12	2022	Curcumol inhibited the viability, proliferation, migration, invasion, and miR-21-5p expression, but increased SMAD7 expression in cancer cells.	curcumol	0-8	SMAD family member 7	Mus musculus	110-115
35253605-13	2022	MiR-21-5p overexpression reversed the effect of curcumol on cancer cells, and decreased the E-cadherin expression while elevating the expressions of PCNA, N-cadherin, Vimentin, p-SMAD2, and p-SMAD3 in curcumol-treated cells.	curcumol	48-56	microRNA 215	Mus musculus	0-9
35253605-13	2022	MiR-21-5p overexpression reversed the effect of curcumol on cancer cells, and decreased the E-cadherin expression while elevating the expressions of PCNA, N-cadherin, Vimentin, p-SMAD2, and p-SMAD3 in curcumol-treated cells.	curcumol	48-56	SMAD family member 2	Mus musculus	179-184
35253605-13	2022	MiR-21-5p overexpression reversed the effect of curcumol on cancer cells, and decreased the E-cadherin expression while elevating the expressions of PCNA, N-cadherin, Vimentin, p-SMAD2, and p-SMAD3 in curcumol-treated cells.	curcumol	48-56	SMAD family member 3	Mus musculus	192-197
35253605-13	2022	MiR-21-5p overexpression reversed the effect of curcumol on cancer cells, and decreased the E-cadherin expression while elevating the expressions of PCNA, N-cadherin, Vimentin, p-SMAD2, and p-SMAD3 in curcumol-treated cells.	curcumol	201-209	microRNA 215	Mus musculus	0-9
35253605-14	2022	The overexpression of SMAD7, a target gene of miR-21-5p, reversed the effect of miR-21-5p on curcumol-treated cells.	curcumol	93-101	SMAD family member 7	Mus musculus	22-27
35253605-14	2022	The overexpression of SMAD7, a target gene of miR-21-5p, reversed the effect of miR-21-5p on curcumol-treated cells.	curcumol	93-101	microRNA 215	Mus musculus	46-55
35253605-14	2022	The overexpression of SMAD7, a target gene of miR-21-5p, reversed the effect of miR-21-5p on curcumol-treated cells.	curcumol	93-101	microRNA 21	Homo sapiens	80-86
35253605-15	2022	Curcumol inhibited growth of xenograft-tumors and the biological activities of pancreatic cancer cells by regulating the miR-21-5p/SMAD7 axis.	curcumol	0-8	microRNA 215	Mus musculus	121-130
35253605-15	2022	Curcumol inhibited growth of xenograft-tumors and the biological activities of pancreatic cancer cells by regulating the miR-21-5p/SMAD7 axis.	curcumol	0-8	SMAD family member 7	Mus musculus	131-136
35545249-3	2022	Western blot and MTT analysis indicated that curcumol could relieve hepatic fibrosis by promoting HSCs receptor-interacting protein kinase 1/3 (RIP1/RIP3)-dependent necroptosis.	curcumol	45-53	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	144-148
35545249-3	2022	Western blot and MTT analysis indicated that curcumol could relieve hepatic fibrosis by promoting HSCs receptor-interacting protein kinase 1/3 (RIP1/RIP3)-dependent necroptosis.	curcumol	45-53	receptor-interacting serine-threonine kinase 3	Mus musculus	149-153
35545249-5	2022	Our study suggested that the activation of necrosome formed by RIP1 and RIP3 depended on Atg5, and that autophagosomes were also necessary for curcumol-induced necroptosis.	curcumol	143-151	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	63-67
35582617-6	2022	Receptor-interacting protein kinase 3 (RIP3) silencing could impair necroptosis induced by curcumol.	curcumol	91-99	receptor-interacting serine-threonine kinase 3	Mus musculus	0-37
35545249-6	2022	Furthermore, microscale thermophoresis and co-immunoprecipitation assay results proved that curcumol could target Sirt1 to regulate autophagy by reducing the acetylation level of Atg5.	curcumol	92-100	sirtuin 1	Mus musculus	114-119
35545249-6	2022	Furthermore, microscale thermophoresis and co-immunoprecipitation assay results proved that curcumol could target Sirt1 to regulate autophagy by reducing the acetylation level of Atg5.	curcumol	92-100	autophagy related 5	Mus musculus	179-183
35545249-9	2022	Overall, our study indicated that curcumol could activate Sirt1 to promote Atg5 deacetylation and enhanced its protein-protein interaction function, thereby inducing autophagy and promoting the necroptosis of HSCs to reduce liver fibrosis.	curcumol	34-42	sirtuin 1	Mus musculus	58-63
35545249-9	2022	Overall, our study indicated that curcumol could activate Sirt1 to promote Atg5 deacetylation and enhanced its protein-protein interaction function, thereby inducing autophagy and promoting the necroptosis of HSCs to reduce liver fibrosis.	curcumol	34-42	autophagy related 5	Mus musculus	75-79
35582617-6	2022	Receptor-interacting protein kinase 3 (RIP3) silencing could impair necroptosis induced by curcumol.	curcumol	91-99	receptor-interacting serine-threonine kinase 3	Mus musculus	39-43
35582617-9	2022	We proved that ER stress regulated curcumol-induced necroptosis in HSCs via Sirtuin-1(Sirt1)/Notch signaling pathway.	curcumol	35-43	sirtuin 1	Mus musculus	76-85
35582617-9	2022	We proved that ER stress regulated curcumol-induced necroptosis in HSCs via Sirtuin-1(Sirt1)/Notch signaling pathway.	curcumol	35-43	sirtuin 1	Mus musculus	86-91
35548853-11	2022	Conclusion: Curcumol can inhibit the invasion, migration and epithelial-mesenchymal transformation of IGROV-1 and OVCAR-3 cells in ovarian cancer, and its mechanism is related to the targeted inhibition of PAX8.	curcumol	12-20	paired box 8	Homo sapiens	206-210
35548853-12	2022	Curcumol also increased the sensitivity of Niraparib chemotherapy by inhibiting PAX8.	curcumol	0-8	paired box 8	Homo sapiens	80-84
35548853-0	2022	Curcumol Targeting PAX8 Inhibits Ovarian Cancer Cell Migration and Invasion and Increases Chemotherapy Sensitivity of Niraparib.	curcumol	0-8	paired box 8	Homo sapiens	19-23
35520289-8	2022	The network pharmacology analysis identified seven core targets (namely, AURKA, CDK1, CCNB1, CCNB2, CCNE1, CCNE2, and TTK) of curcumol in patients with COVID-19 and LUAD.	curcumol	126-134	aurora kinase A	Homo sapiens	73-78
35548853-6	2022	The inhibitory effect of Curcumol on PAX8 was detected by QRT-PCR.	curcumol	25-33	paired box 8	Homo sapiens	37-41
35548853-10	2022	Mechanism studies showed that Curcumol increased the antitumor activity of Niraparib by inhibiting PAX8.	curcumol	30-38	paired box 8	Homo sapiens	99-103
35510522-6	2022	The Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that the curcumol-affected genes, including the target genes of miR-7, were enriched in the nuclear factor-kappa B (NF-kappaB) pathway, whose activity was suppressed after curcumol treatment.	curcumol	88-96	nuclear factor kappa B subunit 1	Homo sapiens	171-193
35510522-6	2022	The Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that the curcumol-affected genes, including the target genes of miR-7, were enriched in the nuclear factor-kappa B (NF-kappaB) pathway, whose activity was suppressed after curcumol treatment.	curcumol	88-96	nuclear factor kappa B subunit 1	Homo sapiens	195-204
35510522-6	2022	The Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that the curcumol-affected genes, including the target genes of miR-7, were enriched in the nuclear factor-kappa B (NF-kappaB) pathway, whose activity was suppressed after curcumol treatment.	curcumol	251-259	nuclear factor kappa B subunit 1	Homo sapiens	171-193
35510522-6	2022	The Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that the curcumol-affected genes, including the target genes of miR-7, were enriched in the nuclear factor-kappa B (NF-kappaB) pathway, whose activity was suppressed after curcumol treatment.	curcumol	251-259	nuclear factor kappa B subunit 1	Homo sapiens	195-204
35510522-8	2022	Downregulation of miR-7 blocked the sensitizing effects of curcumol on cells to cisplatin and led to increased expression of NF-kappaB p65 and snail family transcriptional repressor 1 (SNAIL).	curcumol	59-67	RELA proto-oncogene, NF-kB subunit	Homo sapiens	125-138
35510522-8	2022	Downregulation of miR-7 blocked the sensitizing effects of curcumol on cells to cisplatin and led to increased expression of NF-kappaB p65 and snail family transcriptional repressor 1 (SNAIL).	curcumol	59-67	snail family transcriptional repressor 1	Homo sapiens	143-183
35510522-8	2022	Downregulation of miR-7 blocked the sensitizing effects of curcumol on cells to cisplatin and led to increased expression of NF-kappaB p65 and snail family transcriptional repressor 1 (SNAIL).	curcumol	59-67	snail family transcriptional repressor 1	Homo sapiens	185-190
35510522-10	2022	In summary, this study suggests that curcumol sensitizes GC cells to cisplatin via miR-7 and the suppression of the NF-kappaB/SNAIL axis.	curcumol	37-45	nuclear factor kappa B subunit 1	Homo sapiens	116-125
35510522-10	2022	In summary, this study suggests that curcumol sensitizes GC cells to cisplatin via miR-7 and the suppression of the NF-kappaB/SNAIL axis.	curcumol	37-45	snail family transcriptional repressor 1	Homo sapiens	126-131
35520289-8	2022	The network pharmacology analysis identified seven core targets (namely, AURKA, CDK1, CCNB1, CCNB2, CCNE1, CCNE2, and TTK) of curcumol in patients with COVID-19 and LUAD.	curcumol	126-134	cyclin dependent kinase 1	Homo sapiens	80-84
35520289-8	2022	The network pharmacology analysis identified seven core targets (namely, AURKA, CDK1, CCNB1, CCNB2, CCNE1, CCNE2, and TTK) of curcumol in patients with COVID-19 and LUAD.	curcumol	126-134	cyclin B1	Homo sapiens	86-91
35520289-8	2022	The network pharmacology analysis identified seven core targets (namely, AURKA, CDK1, CCNB1, CCNB2, CCNE1, CCNE2, and TTK) of curcumol in patients with COVID-19 and LUAD.	curcumol	126-134	cyclin B2	Homo sapiens	93-98
35520289-8	2022	The network pharmacology analysis identified seven core targets (namely, AURKA, CDK1, CCNB1, CCNB2, CCNE1, CCNE2, and TTK) of curcumol in patients with COVID-19 and LUAD.	curcumol	126-134	cyclin E1	Homo sapiens	100-105
35520289-8	2022	The network pharmacology analysis identified seven core targets (namely, AURKA, CDK1, CCNB1, CCNB2, CCNE1, CCNE2, and TTK) of curcumol in patients with COVID-19 and LUAD.	curcumol	126-134	cyclin E2	Homo sapiens	107-112
35520289-8	2022	The network pharmacology analysis identified seven core targets (namely, AURKA, CDK1, CCNB1, CCNB2, CCNE1, CCNE2, and TTK) of curcumol in patients with COVID-19 and LUAD.	curcumol	126-134	TTK protein kinase	Homo sapiens	118-121
35083610-7	2022	Next, curcumol repressed glutaminase 1 (Gls1) mRNA and protein expression, and overexpression of Gls1 promoted EMT and abolished curcumol effects on CRC cell EMT.	curcumol	6-14	glutaminase	Homo sapiens	40-44
35279667-0	2022	Curcumol Attenuates Endometriosis by Inhibiting the JAK2/STAT3 Signaling Pathway.	curcumol	0-8	Janus kinase 2	Rattus norvegicus	52-56
35279667-0	2022	Curcumol Attenuates Endometriosis by Inhibiting the JAK2/STAT3 Signaling Pathway.	curcumol	0-8	signal transducer and activator of transcription 3	Rattus norvegicus	57-62
35279667-11	2022	Curcumol can reduce the expression of Bax and caspase-3 protein and increase the expression of Bcl2 protein.	curcumol	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	38-41
35279667-11	2022	Curcumol can reduce the expression of Bax and caspase-3 protein and increase the expression of Bcl2 protein.	curcumol	0-8	caspase 3	Rattus norvegicus	46-55
35279667-11	2022	Curcumol can reduce the expression of Bax and caspase-3 protein and increase the expression of Bcl2 protein.	curcumol	0-8	BCL2, apoptosis regulator	Rattus norvegicus	95-99
35279667-12	2022	Curcumol also can inhibit the secretion of inflammatory cytokines, including tumor necrosis cytokines (TNF)-alpha, interleukin (IL)-6, and IL-1ss, by ectopic endometrial stromal cells.	curcumol	0-8	tumor necrosis factor	Rattus norvegicus	77-113
35279667-12	2022	Curcumol also can inhibit the secretion of inflammatory cytokines, including tumor necrosis cytokines (TNF)-alpha, interleukin (IL)-6, and IL-1ss, by ectopic endometrial stromal cells.	curcumol	0-8	interleukin 6	Rattus norvegicus	115-133
35279667-13	2022	In addition, curcumol can also inhibit the phosphorylation of JAK2 and STAT3.	curcumol	13-21	Janus kinase 2	Rattus norvegicus	62-66
35279667-13	2022	In addition, curcumol can also inhibit the phosphorylation of JAK2 and STAT3.	curcumol	13-21	signal transducer and activator of transcription 3	Rattus norvegicus	71-76
35279667-15	2022	CONCLUSIONS Curcumol can inhibit the JAK2/STAT3 pathway, reduce the inflammatory cytokines secreted by ectopic endometrial stromal cells, inhibit cell proliferation and migration, and reduce the volume of ectopic lesions.	curcumol	12-20	Janus kinase 2	Rattus norvegicus	37-41
35279667-15	2022	CONCLUSIONS Curcumol can inhibit the JAK2/STAT3 pathway, reduce the inflammatory cytokines secreted by ectopic endometrial stromal cells, inhibit cell proliferation and migration, and reduce the volume of ectopic lesions.	curcumol	12-20	signal transducer and activator of transcription 3	Rattus norvegicus	42-47
35083610-0	2022	Degradation of HIF-1alpha induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells.	curcumol	37-45	hypoxia inducible factor 1, alpha subunit	Mus musculus	15-25
35083610-5	2022	We observed that curcumol suppressed invasion and migration in human CRC cells associated with upregulation of epithelial markers E-cadherin and Zonula occludens 1 and downregulation of mesenchymal markers N-cadherin and Vimentin as well as EMT-related transcription factors Snail and Twist.	curcumol	17-25	cadherin 1	Homo sapiens	130-140
35083610-5	2022	We observed that curcumol suppressed invasion and migration in human CRC cells associated with upregulation of epithelial markers E-cadherin and Zonula occludens 1 and downregulation of mesenchymal markers N-cadherin and Vimentin as well as EMT-related transcription factors Snail and Twist.	curcumol	17-25	cadherin 2	Homo sapiens	206-216
35083610-5	2022	We observed that curcumol suppressed invasion and migration in human CRC cells associated with upregulation of epithelial markers E-cadherin and Zonula occludens 1 and downregulation of mesenchymal markers N-cadherin and Vimentin as well as EMT-related transcription factors Snail and Twist.	curcumol	17-25	vimentin	Homo sapiens	221-229
35083610-8	2022	Molecular examinations showed that curcumol stimulated protein degradation of hypoxia-inducible factor-1alpha (HIF-1alpha) and prevented its nuclear accumulation in CRC cells.	curcumol	35-43	hypoxia inducible factor 1, alpha subunit	Mus musculus	78-109
35083610-8	2022	Molecular examinations showed that curcumol stimulated protein degradation of hypoxia-inducible factor-1alpha (HIF-1alpha) and prevented its nuclear accumulation in CRC cells.	curcumol	35-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-121
35083610-9	2022	HIF-1alpha agonist deferoxamine (DFO) promoted HIF-1alpha binding to Gls1 promoter and increased Gls1 expression but abolished curcumol"s inhibitory effects on Gls1 expression.	curcumol	127-135	glutaminase	Homo sapiens	160-164
35083610-12	2022	Curcumol effectively inhibited CRC growth, metastasis, and EMT in mice, which was abrogated by overexpression of HIF-1alpha or Gls1.	curcumol	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	113-123
35083610-5	2022	We observed that curcumol suppressed invasion and migration in human CRC cells associated with upregulation of epithelial markers E-cadherin and Zonula occludens 1 and downregulation of mesenchymal markers N-cadherin and Vimentin as well as EMT-related transcription factors Snail and Twist.	curcumol	17-25	twist family bHLH transcription factor 1	Homo sapiens	285-290
35083610-12	2022	Curcumol effectively inhibited CRC growth, metastasis, and EMT in mice, which was abrogated by overexpression of HIF-1alpha or Gls1.	curcumol	0-8	glutaminase	Homo sapiens	127-131
35083610-13	2022	Altogether, stimulation of HIF-1alpha degradation was required for curcumol to disrupt EMT and repress invasion and migration in CRC cells through inhibiting Gls1-mediated glutaminolysis.	curcumol	67-75	hypoxia inducible factor 1, alpha subunit	Mus musculus	27-37
35083610-13	2022	Altogether, stimulation of HIF-1alpha degradation was required for curcumol to disrupt EMT and repress invasion and migration in CRC cells through inhibiting Gls1-mediated glutaminolysis.	curcumol	67-75	glutaminase	Homo sapiens	158-162
35083610-16	2022	Inhibition of Gls1 is required for curcumol blockade of glutaminolysis and EMT.	curcumol	35-43	glutaminase	Homo sapiens	14-18
35083610-17	2022	Curcumol induces HIF-1alpha degradation leading to inhibition of Gls1 and blockade of glutaminolysis and EMT.	curcumol	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	17-27
35083610-17	2022	Curcumol induces HIF-1alpha degradation leading to inhibition of Gls1 and blockade of glutaminolysis and EMT.	curcumol	0-8	glutaminase	Homo sapiens	65-69
35083610-18	2022	Curcumol suppresses CRC growth and metastasis via inhibiting HIF-1alpha, glutaminolysis and EMT in mice.	curcumol	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	61-71
33274566-7	2021	In our study, we find that FTY720 and curcumol have a significant inhibitory effect on K562 cells, K562/ADR cells, and CD34+ cells from CML patients.	curcumol	38-46	CD34 molecule	Homo sapiens	119-123
33732375-6	2021	Curcumol treatment was identified to increase miR-30a-5p expression and to activate the Hippo signaling pathway, which in turn inhibited the invasion and migration of CRC cells.	curcumol	0-8	microRNA 30a	Homo sapiens	46-53
33732375-7	2021	Overexpression of miR-30a-5p enhanced the effects of curcumol on cell invasion and migration, and the Hippo signaling pathway in CRC cells.	curcumol	53-61	microRNA 30a	Homo sapiens	18-25
33732375-8	2021	Furthermore, downregulation of miR-30a-5p reversed the effects of curcumol on cell invasion and migration, and the Hippo signaling pathway in CRC cells.	curcumol	66-74	microRNA 30a	Homo sapiens	31-38
34873892-0	2022	Curcumol inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells by suppressing ERK/CREB pathway.	curcumol	0-8	mitogen-activated protein kinase 1	Homo sapiens	107-110
34873892-0	2022	Curcumol inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells by suppressing ERK/CREB pathway.	curcumol	0-8	cAMP responsive element binding protein 1	Homo sapiens	111-115
34873892-7	2022	The regulatory effects of curcumol on extracellular signal-regulated protein kinase (ERK)/cAMP response element-binding protein (CREB) pathway was evaluated by Western blotting.	curcumol	26-34	mitogen-activated protein kinase 1	Homo sapiens	38-83
34873892-7	2022	The regulatory effects of curcumol on extracellular signal-regulated protein kinase (ERK)/cAMP response element-binding protein (CREB) pathway was evaluated by Western blotting.	curcumol	26-34	mitogen-activated protein kinase 1	Homo sapiens	85-88
34873892-7	2022	The regulatory effects of curcumol on extracellular signal-regulated protein kinase (ERK)/cAMP response element-binding protein (CREB) pathway was evaluated by Western blotting.	curcumol	26-34	cAMP responsive element binding protein 1	Homo sapiens	129-133
34873892-9	2022	The activation of ERK/CREB pathway induced by PDGF-BB was suppressed by curcumol.	curcumol	72-80	mitogen-activated protein kinase 1	Homo sapiens	18-21
34873892-9	2022	The activation of ERK/CREB pathway induced by PDGF-BB was suppressed by curcumol.	curcumol	72-80	cAMP responsive element binding protein 1	Homo sapiens	22-26
34873892-10	2022	CONCLUSION: Curcumol could suppress ERK/CREB pathway to inhibit proliferation and migration and promote apoptosis of PDGF-BB-stimulated ASMCs.	curcumol	12-20	mitogen-activated protein kinase 1	Homo sapiens	36-39
34873892-10	2022	CONCLUSION: Curcumol could suppress ERK/CREB pathway to inhibit proliferation and migration and promote apoptosis of PDGF-BB-stimulated ASMCs.	curcumol	12-20	cAMP responsive element binding protein 1	Homo sapiens	40-44
33010370-4	2020	Herein, we obtained 5 sesquiterpenoids, named curzerenone, curdione, furanodienone, curcumol and germacrone with TMEM16A inhibition and revealed their mechanism of action by fluorescent and electrophysiological assays.	curcumol	84-92	anoctamin 1	Homo sapiens	113-120
33549628-0	2021	Autophagy-induced p62 accumulation is required for curcumol to regulate KLF5-mediated angiogenesis in liver sinusoidal endothelial cells.	curcumol	51-59	nucleoporin 62	Mus musculus	18-21
33549628-0	2021	Autophagy-induced p62 accumulation is required for curcumol to regulate KLF5-mediated angiogenesis in liver sinusoidal endothelial cells.	curcumol	51-59	Kruppel-like factor 5	Mus musculus	72-76
33549628-7	2021	Furthermore, we indicated that the transcription factor Kruppel-like factor 5 (KLF5) was considered as a key target for curcumol to regulate LSEC angiogenesis.	curcumol	120-128	Kruppel-like factor 5	Mus musculus	56-77
33549628-7	2021	Furthermore, we indicated that the transcription factor Kruppel-like factor 5 (KLF5) was considered as a key target for curcumol to regulate LSEC angiogenesis.	curcumol	120-128	Kruppel-like factor 5	Mus musculus	79-83
33549628-8	2021	Interestingly, we also suggested that autophagy was as a potential mechanism for curcumol to restrain KLF5 expression.	curcumol	81-89	Kruppel-like factor 5	Mus musculus	102-106
33549628-9	2021	Increased autophagy level could impair the suppression effect of curcumol on KLF5.	curcumol	65-73	Kruppel-like factor 5	Mus musculus	77-81
33549628-10	2021	Fascinatingly, our results indicated that curcumol inhibited autophagy and led to p62 accumulation, which might be a regulation mechanism of KLF5 degradation.	curcumol	42-50	nucleoporin 62	Mus musculus	82-85
33549628-10	2021	Fascinatingly, our results indicated that curcumol inhibited autophagy and led to p62 accumulation, which might be a regulation mechanism of KLF5 degradation.	curcumol	42-50	Kruppel-like factor 5	Mus musculus	141-145
33549628-11	2021	Finally, in mice liver fibrosis model, we unanimously showed that curcumol (30 mg/kg) inhibited pathological angiogenesis by reducing LSEC autophagy level and suppressing KLF5 expression.	curcumol	66-74	Kruppel-like factor 5	Mus musculus	171-175
33157090-0	2021	Curcumol inhibits KLF5-dependent angiogenesis by blocking the ROS/ERK signaling in liver sinusoidal endothelial cells.	curcumol	0-8	Kruppel-like factor 5	Mus musculus	18-22
33157090-0	2021	Curcumol inhibits KLF5-dependent angiogenesis by blocking the ROS/ERK signaling in liver sinusoidal endothelial cells.	curcumol	0-8	mitogen-activated protein kinase 1	Mus musculus	66-69
33157090-9	2021	Interestingly, this process may depend on curcumol"s inhibition of the expression of transcription factor KLF5.	curcumol	42-50	Kruppel-like factor 5	Mus musculus	106-110
33157090-10	2021	Mice experiment also showed that curcumol could alleviate chronic liver injury by reducing KLF5 expression.	curcumol	33-41	Kruppel-like factor 5	Mus musculus	91-95
33157090-12	2021	More importantly, we proved that curcumol could suppress KLF5-mediated LSEC angiogenesis by inhibiting ROS/ERK signaling.	curcumol	33-41	Kruppel-like factor 5	Mus musculus	57-61
33157090-12	2021	More importantly, we proved that curcumol could suppress KLF5-mediated LSEC angiogenesis by inhibiting ROS/ERK signaling.	curcumol	33-41	mitogen-activated protein kinase 1	Mus musculus	107-110
33157090-13	2021	SIGNIFICANCE: We suggested that transcription factor KLF5 could be considered as a new target molecule of curcumol in improving liver fibrosis, and pointed out that curcumol targeted ROS/ERK-mediated KLF5 expression could inhibit LSEC angiogenesis.	curcumol	106-114	Kruppel-like factor 5	Mus musculus	53-57
33157090-13	2021	SIGNIFICANCE: We suggested that transcription factor KLF5 could be considered as a new target molecule of curcumol in improving liver fibrosis, and pointed out that curcumol targeted ROS/ERK-mediated KLF5 expression could inhibit LSEC angiogenesis.	curcumol	106-114	mitogen-activated protein kinase 1	Mus musculus	187-190
33157090-13	2021	SIGNIFICANCE: We suggested that transcription factor KLF5 could be considered as a new target molecule of curcumol in improving liver fibrosis, and pointed out that curcumol targeted ROS/ERK-mediated KLF5 expression could inhibit LSEC angiogenesis.	curcumol	165-173	mitogen-activated protein kinase 1	Mus musculus	187-190
33157090-13	2021	SIGNIFICANCE: We suggested that transcription factor KLF5 could be considered as a new target molecule of curcumol in improving liver fibrosis, and pointed out that curcumol targeted ROS/ERK-mediated KLF5 expression could inhibit LSEC angiogenesis.	curcumol	165-173	Kruppel-like factor 5	Mus musculus	200-204
32988876-6	2020	Additionally, these anti-cancer effects induced by curcumol could be related to the YAP1/Skp2 molecular pathway.	curcumol	51-59	S-phase kinase associated protein 2	Homo sapiens	89-93
33240775-0	2020	Curcumol Overcomes TRAIL Resistance of Non-Small Cell Lung Cancer by Targeting NRH:Quinone Oxidoreductase 2 (NQO2).	curcumol	0-8	TNF superfamily member 10	Homo sapiens	19-24
33240775-0	2020	Curcumol Overcomes TRAIL Resistance of Non-Small Cell Lung Cancer by Targeting NRH:Quinone Oxidoreductase 2 (NQO2).	curcumol	0-8	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	79-107
33240775-0	2020	Curcumol Overcomes TRAIL Resistance of Non-Small Cell Lung Cancer by Targeting NRH:Quinone Oxidoreductase 2 (NQO2).	curcumol	0-8	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	109-113
33240775-2	2020	To overcome TRAIL resistance, this study identifies curcumol as a novel safe sensitizer from a food-source compound library, which exhibits synergistic lethal effects in combination with TRAIL on non-small cell lung cancer (NSCLC).	curcumol	52-60	TNF superfamily member 10	Homo sapiens	12-17
33240775-2	2020	To overcome TRAIL resistance, this study identifies curcumol as a novel safe sensitizer from a food-source compound library, which exhibits synergistic lethal effects in combination with TRAIL on non-small cell lung cancer (NSCLC).	curcumol	52-60	TNF superfamily member 10	Homo sapiens	187-192
33240775-3	2020	SILAC-based cellular thermal shift profiling identifies NRH:quinone oxidoreductase 2 (NQO2) as the key target of curcumol.	curcumol	113-121	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	56-84
33240775-3	2020	SILAC-based cellular thermal shift profiling identifies NRH:quinone oxidoreductase 2 (NQO2) as the key target of curcumol.	curcumol	113-121	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	86-90
33240775-4	2020	Mechanistically, curcumol directly targets NQO2 to cause reactive oxygen species (ROS) generation, which triggers endoplasmic reticulum (ER) stress-C/EBP homologous protein (CHOP) death receptor (DR5) signaling, sensitizing NSCLC cell to TRAIL-induced apoptosis.	curcumol	17-25	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	43-47
33240775-4	2020	Mechanistically, curcumol directly targets NQO2 to cause reactive oxygen species (ROS) generation, which triggers endoplasmic reticulum (ER) stress-C/EBP homologous protein (CHOP) death receptor (DR5) signaling, sensitizing NSCLC cell to TRAIL-induced apoptosis.	curcumol	17-25	TNF receptor superfamily member 10b	Homo sapiens	196-199
33240775-4	2020	Mechanistically, curcumol directly targets NQO2 to cause reactive oxygen species (ROS) generation, which triggers endoplasmic reticulum (ER) stress-C/EBP homologous protein (CHOP) death receptor (DR5) signaling, sensitizing NSCLC cell to TRAIL-induced apoptosis.	curcumol	17-25	TNF superfamily member 10	Homo sapiens	238-243
32988876-0	2020	Curcumol Suppresses Triple-negative Breast Cancer Metastasis by Attenuating Anoikis Resistance via Inhibition of Skp2-mediated Transcriptional Addiction.	curcumol	0-8	S-phase kinase associated protein 2	Homo sapiens	113-117
32988876-6	2020	Additionally, these anti-cancer effects induced by curcumol could be related to the YAP1/Skp2 molecular pathway.	curcumol	51-59	Yes1 associated transcriptional regulator	Homo sapiens	84-88
33240775-5	2020	Molecular docking analysis and surface plasmon resonance assay demonstrate that Phe178 in NQO2 is a critical site for curcumol binding.	curcumol	118-126	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	90-94
33240775-7	2020	This study characterizes the functional role of NQO2 in TRAIL resistance and the sensitizing function of curcumol by directly targeting NQO2, highlighting the potential of using curcumol as an NQO2 inhibitor for clinical treatment of TRAIL-resistant cancers.	curcumol	105-113	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	136-140
33240775-7	2020	This study characterizes the functional role of NQO2 in TRAIL resistance and the sensitizing function of curcumol by directly targeting NQO2, highlighting the potential of using curcumol as an NQO2 inhibitor for clinical treatment of TRAIL-resistant cancers.	curcumol	105-113	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	136-140
33240775-7	2020	This study characterizes the functional role of NQO2 in TRAIL resistance and the sensitizing function of curcumol by directly targeting NQO2, highlighting the potential of using curcumol as an NQO2 inhibitor for clinical treatment of TRAIL-resistant cancers.	curcumol	178-186	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	48-52
33240775-7	2020	This study characterizes the functional role of NQO2 in TRAIL resistance and the sensitizing function of curcumol by directly targeting NQO2, highlighting the potential of using curcumol as an NQO2 inhibitor for clinical treatment of TRAIL-resistant cancers.	curcumol	178-186	TNF superfamily member 10	Homo sapiens	56-61
33240775-7	2020	This study characterizes the functional role of NQO2 in TRAIL resistance and the sensitizing function of curcumol by directly targeting NQO2, highlighting the potential of using curcumol as an NQO2 inhibitor for clinical treatment of TRAIL-resistant cancers.	curcumol	178-186	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	136-140
33240775-7	2020	This study characterizes the functional role of NQO2 in TRAIL resistance and the sensitizing function of curcumol by directly targeting NQO2, highlighting the potential of using curcumol as an NQO2 inhibitor for clinical treatment of TRAIL-resistant cancers.	curcumol	178-186	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	136-140
33240775-7	2020	This study characterizes the functional role of NQO2 in TRAIL resistance and the sensitizing function of curcumol by directly targeting NQO2, highlighting the potential of using curcumol as an NQO2 inhibitor for clinical treatment of TRAIL-resistant cancers.	curcumol	178-186	TNF superfamily member 10	Homo sapiens	234-239
32988876-7	2020	CONCLUSION: Curcumol is an effective Skp2-targeted therapy that attenuates anoikis resistance and metastasis in TNBC cells.	curcumol	12-20	S-phase kinase associated protein 2	Homo sapiens	37-41
32953746-16	2020	The combination of curcumol and metformin also suppressed tumor growth, EMT marker expression, and the activation of Wnt2/beta-Catenin signaling during in vivo experiments.	curcumol	19-27	Wnt family member 2	Homo sapiens	117-121
32953746-16	2020	The combination of curcumol and metformin also suppressed tumor growth, EMT marker expression, and the activation of Wnt2/beta-Catenin signaling during in vivo experiments.	curcumol	19-27	catenin beta 1	Homo sapiens	122-134
32278762-0	2020	Curcumol inhibits the expression of programmed cell death-ligand 1 through crosstalk between hypoxia-inducible factor-1alpha and STAT3 (T705) signaling pathways in hepatic cancer.	curcumol	0-8	CD274 molecule	Homo sapiens	36-66
32554101-5	2020	In this study, we have investigated the effects of curcumin and curcumol in the fibroblast overproliferation model human lung fibroblast (HLF) inducing by TGF-beta1.	curcumol	64-72	transforming growth factor beta 1	Homo sapiens	155-164
32554101-7	2020	Administration of curcumin or curcumol significantly diminished the level of hydroxyproline hydroxyproline and alpha-smooth muscle actin (alpha-SMA), also the collagen I (Col-I) and collagen III (Col-III) deposition were reduced in the HLF.	curcumol	30-38	actin alpha 1, skeletal muscle	Homo sapiens	138-147
32554101-7	2020	Administration of curcumin or curcumol significantly diminished the level of hydroxyproline hydroxyproline and alpha-smooth muscle actin (alpha-SMA), also the collagen I (Col-I) and collagen III (Col-III) deposition were reduced in the HLF.	curcumol	30-38	HLF transcription factor, PAR bZIP family member	Homo sapiens	236-239
32554101-9	2020	Autophagy as the scavenger was crippled in TGF-beta1-fibroblast overproliferation HLF, conversely the increased autophagosomes have been spotted in cytoplasm under transmission electron microscope which is consistent with up-regulation of Beclin1 and ATG7 after treatment with curcumin or curcumol in this study.	curcumol	289-297	transforming growth factor beta 1	Homo sapiens	43-52
32715509-0	2020	Curcumol improves cisplatin sensitivity of human gastric cancer cells through inhibiting PI3K/AKT pathway.	curcumol	0-8	AKT serine/threonine kinase 1	Homo sapiens	94-97
32715509-7	2020	Lastly, Western blot assay and qRT-PCR analysis were utilized to check the functions of curcumol on PI3K/AKT pathway-related markers.	curcumol	88-96	AKT serine/threonine kinase 1	Homo sapiens	105-108
32715509-11	2020	It was also presented that curcumol suppressed the PI3K/AKT pathway dose-dependently in BGC-823/DDP and BGC-823 cells.	curcumol	27-35	AKT serine/threonine kinase 1	Homo sapiens	56-59
32715509-12	2020	CONCLUSION: The findings in the current research demonstrated that curcumol could promote the sensitivity of gastric cancer cells to cisplatin-based chemotherapies via inhibiting the phosphatidylinositol 3-kinase (PI3K)/Protein Kinase B (AKT) pathway.	curcumol	67-75	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	183-212
32715509-12	2020	CONCLUSION: The findings in the current research demonstrated that curcumol could promote the sensitivity of gastric cancer cells to cisplatin-based chemotherapies via inhibiting the phosphatidylinositol 3-kinase (PI3K)/Protein Kinase B (AKT) pathway.	curcumol	67-75	protein tyrosine kinase 2 beta	Homo sapiens	220-236
32715509-12	2020	CONCLUSION: The findings in the current research demonstrated that curcumol could promote the sensitivity of gastric cancer cells to cisplatin-based chemotherapies via inhibiting the phosphatidylinositol 3-kinase (PI3K)/Protein Kinase B (AKT) pathway.	curcumol	67-75	AKT serine/threonine kinase 1	Homo sapiens	238-241
32278762-0	2020	Curcumol inhibits the expression of programmed cell death-ligand 1 through crosstalk between hypoxia-inducible factor-1alpha and STAT3 (T705) signaling pathways in hepatic cancer.	curcumol	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-124
32278762-0	2020	Curcumol inhibits the expression of programmed cell death-ligand 1 through crosstalk between hypoxia-inducible factor-1alpha and STAT3 (T705) signaling pathways in hepatic cancer.	curcumol	0-8	signal transducer and activator of transcription 3	Homo sapiens	129-134
32278762-5	2020	MATERIALS AND METHODS: The underlying mechanism of the inhibition of programmed cell death-ligand 1 (PD-L1) activation by curcumol was investigated in vitro via homology modeling, molecular docking experiments, luciferase reporter assays, MTT assays, RT-PCR, western blotting, and immunofluorescence assays.	curcumol	122-130	CD274 molecule	Homo sapiens	69-99
32278762-5	2020	MATERIALS AND METHODS: The underlying mechanism of the inhibition of programmed cell death-ligand 1 (PD-L1) activation by curcumol was investigated in vitro via homology modeling, molecular docking experiments, luciferase reporter assays, MTT assays, RT-PCR, western blotting, and immunofluorescence assays.	curcumol	122-130	CD274 molecule	Homo sapiens	101-106
32278762-8	2020	RESULTS: Curcumol reduced the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) via JAK1, JAK2, and Src pathways and inhibited hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis via mTOR/p70S6K/eIF4E and MAPK pathways.	curcumol	9-17	signal transducer and activator of transcription 3	Homo sapiens	59-109
32278762-8	2020	RESULTS: Curcumol reduced the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) via JAK1, JAK2, and Src pathways and inhibited hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis via mTOR/p70S6K/eIF4E and MAPK pathways.	curcumol	9-17	signal transducer and activator of transcription 3	Homo sapiens	113-118
32278762-8	2020	RESULTS: Curcumol reduced the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) via JAK1, JAK2, and Src pathways and inhibited hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis via mTOR/p70S6K/eIF4E and MAPK pathways.	curcumol	9-17	Janus kinase 1	Homo sapiens	124-128
32278762-8	2020	RESULTS: Curcumol reduced the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) via JAK1, JAK2, and Src pathways and inhibited hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis via mTOR/p70S6K/eIF4E and MAPK pathways.	curcumol	9-17	Janus kinase 2	Homo sapiens	130-134
32278762-8	2020	RESULTS: Curcumol reduced the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) via JAK1, JAK2, and Src pathways and inhibited hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis via mTOR/p70S6K/eIF4E and MAPK pathways.	curcumol	9-17	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	140-143
32278762-8	2020	RESULTS: Curcumol reduced the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) via JAK1, JAK2, and Src pathways and inhibited hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis via mTOR/p70S6K/eIF4E and MAPK pathways.	curcumol	9-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	167-198
32278762-8	2020	RESULTS: Curcumol reduced the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) via JAK1, JAK2, and Src pathways and inhibited hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis via mTOR/p70S6K/eIF4E and MAPK pathways.	curcumol	9-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	200-210
32278762-8	2020	RESULTS: Curcumol reduced the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) via JAK1, JAK2, and Src pathways and inhibited hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis via mTOR/p70S6K/eIF4E and MAPK pathways.	curcumol	9-17	mechanistic target of rapamycin kinase	Homo sapiens	234-238
32278762-8	2020	RESULTS: Curcumol reduced the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) via JAK1, JAK2, and Src pathways and inhibited hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis via mTOR/p70S6K/eIF4E and MAPK pathways.	curcumol	9-17	ribosomal protein S6 kinase B1	Homo sapiens	239-245
32278762-8	2020	RESULTS: Curcumol reduced the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) via JAK1, JAK2, and Src pathways and inhibited hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis via mTOR/p70S6K/eIF4E and MAPK pathways.	curcumol	9-17	eukaryotic translation initiation factor 4E	Homo sapiens	246-251
32278762-10	2020	Curcumol inhibited cell proliferation, S-phase progression, tube formation, invasion, and metastasis by inhibiting PD-L1.	curcumol	0-8	CD274 molecule	Homo sapiens	115-120
32278762-11	2020	In addition, curcumol restored the activity of cytotoxic T-cells and their capacity for tumor cell killing by inhibiting PD-L1.	curcumol	13-21	CD274 molecule	Homo sapiens	121-126
32278762-13	2020	CONCLUSIONS: These results illustrated that curcumol inhibits the expression of PD-L1 through crosstalk between HIF-1alpha and p-STAT3 (T705) signaling pathways in hepatic cancer.	curcumol	44-52	CD274 molecule	Homo sapiens	80-85
32278762-13	2020	CONCLUSIONS: These results illustrated that curcumol inhibits the expression of PD-L1 through crosstalk between HIF-1alpha and p-STAT3 (T705) signaling pathways in hepatic cancer.	curcumol	44-52	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-122
32278762-13	2020	CONCLUSIONS: These results illustrated that curcumol inhibits the expression of PD-L1 through crosstalk between HIF-1alpha and p-STAT3 (T705) signaling pathways in hepatic cancer.	curcumol	44-52	signal transducer and activator of transcription 3	Homo sapiens	129-134
32344006-0	2020	Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells.	curcumol	58-66	periostin	Homo sapiens	12-21
32344006-0	2020	Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells.	curcumol	58-66	nuclear factor kappa B subunit 1	Homo sapiens	85-107
32344006-10	2020	RESULTS: Curcumol suppressed HSC migration and adhesion, and reduced the secretion and expression of POSTN.	curcumol	9-17	periostin	Homo sapiens	101-106
32344006-11	2020	By gain of function POSTN in HSCs, using rh POSTN, we found that the inhibition of HSC migration and adhesion by curcumol depended on the decrease of POSTN.	curcumol	113-121	periostin	Homo sapiens	20-25
32344006-11	2020	By gain of function POSTN in HSCs, using rh POSTN, we found that the inhibition of HSC migration and adhesion by curcumol depended on the decrease of POSTN.	curcumol	113-121	periostin	Homo sapiens	44-49
32344006-11	2020	By gain of function POSTN in HSCs, using rh POSTN, we found that the inhibition of HSC migration and adhesion by curcumol depended on the decrease of POSTN.	curcumol	113-121	periostin	Homo sapiens	44-49
32344006-12	2020	Besides, curcumol protection against chronic CCl4-caused hepatic fibrosis could be impaired by POSTN overexpression.	curcumol	9-17	periostin	Homo sapiens	95-100
32344006-13	2020	Moreover, we showed that curcumol repressed NF-kappaB signaling and the production of pro-inflammatory factor.	curcumol	25-33	nuclear factor kappa B subunit 1	Homo sapiens	44-53
32344006-14	2020	Importantly, curcumol down-regulation of POSTN was rescued by knock-in of NF-kappaB, as well as the inhibition of HSC migration and adhesion.	curcumol	13-21	periostin	Homo sapiens	41-46
32344006-14	2020	Importantly, curcumol down-regulation of POSTN was rescued by knock-in of NF-kappaB, as well as the inhibition of HSC migration and adhesion.	curcumol	13-21	nuclear factor kappa B subunit 1	Homo sapiens	74-83
32344006-15	2020	CONCLUSION: These findings reveal the molecular mechanism of curcumol-reduced HSC migration and adhesion, by which points to the possibility of using curcumol based on NF-kappaB dependent POSTN for the treatment of fibrogenesis.	curcumol	61-69	nuclear factor kappa B subunit 1	Homo sapiens	168-177
32344006-15	2020	CONCLUSION: These findings reveal the molecular mechanism of curcumol-reduced HSC migration and adhesion, by which points to the possibility of using curcumol based on NF-kappaB dependent POSTN for the treatment of fibrogenesis.	curcumol	61-69	periostin	Homo sapiens	188-193
32344006-15	2020	CONCLUSION: These findings reveal the molecular mechanism of curcumol-reduced HSC migration and adhesion, by which points to the possibility of using curcumol based on NF-kappaB dependent POSTN for the treatment of fibrogenesis.	curcumol	150-158	nuclear factor kappa B subunit 1	Homo sapiens	168-177
32344006-15	2020	CONCLUSION: These findings reveal the molecular mechanism of curcumol-reduced HSC migration and adhesion, by which points to the possibility of using curcumol based on NF-kappaB dependent POSTN for the treatment of fibrogenesis.	curcumol	150-158	periostin	Homo sapiens	188-193
32886059-0	2021	Curcumol inhibits lung adenocarcinoma growth and metastasis via inactivation of PI3K/AKT and Wnt/ss-catenin pathway.	curcumol	0-8	thymoma viral proto-oncogene 1	Mus musculus	85-88
31926937-0	2020	Curcumol enhances the sensitivity of doxorubicin in triple-negative breast cancer via regulating the miR-181b-2-3p-ABCC3 axis.	curcumol	0-8	microRNA 181b-2	Homo sapiens	101-111
31989700-0	2020	Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.	curcumol	0-8	plasminogen activator, urokinase	Rattus norvegicus	86-89
31989700-0	2020	Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.	curcumol	0-8	plasminogen activator, urokinase receptor	Rattus norvegicus	90-94
31989700-7	2020	Quantitative polymerase chain reaction and Western blot results revealed that increased levels of urokinase plasminogen activator (uPA)/ uPA receptor (uPAR) were observed both in vivo and in vitro, curcumol significantly reduced uPA/uPAR at both the mRNA and protein levels.	curcumol	198-206	plasminogen activator, urokinase	Rattus norvegicus	98-129
31989700-7	2020	Quantitative polymerase chain reaction and Western blot results revealed that increased levels of urokinase plasminogen activator (uPA)/ uPA receptor (uPAR) were observed both in vivo and in vitro, curcumol significantly reduced uPA/uPAR at both the mRNA and protein levels.	curcumol	198-206	plasminogen activator, urokinase receptor	Rattus norvegicus	151-155
31989700-7	2020	Quantitative polymerase chain reaction and Western blot results revealed that increased levels of urokinase plasminogen activator (uPA)/ uPA receptor (uPAR) were observed both in vivo and in vitro, curcumol significantly reduced uPA/uPAR at both the mRNA and protein levels.	curcumol	198-206	plasminogen activator, urokinase receptor	Rattus norvegicus	233-237
31989700-9	2020	In conclusion, curcumol protects liver from phenotypic changes in the early and advanced fibrogenesis, possibly through uPA/uPAR pathway.	curcumol	15-23	plasminogen activator, urokinase	Rattus norvegicus	120-123
31989700-9	2020	In conclusion, curcumol protects liver from phenotypic changes in the early and advanced fibrogenesis, possibly through uPA/uPAR pathway.	curcumol	15-23	plasminogen activator, urokinase receptor	Rattus norvegicus	124-128
32595742-0	2020	Effect of Curcumol on the Fenestrae of Liver Sinusoidal Endothelial Cells Based on NF-kappaB Signaling Pathway.	curcumol	10-18	nuclear factor kappa B subunit 1	Homo sapiens	83-92
32595742-6	2020	RT-PCR showed that the expression of NF-kappaB in the curcumol intervention group was significantly lower than that in the positive control group (P < 0.05).	curcumol	54-62	nuclear factor kappa B subunit 1	Homo sapiens	37-46
32595742-7	2020	The WB detection found that, in the curcumol intervention group, the expression of pNF-kappaB in the NF-kappaB signaling pathway was significantly lower than that in the positive control group (P < 0.05).	curcumol	36-44	nuclear factor kappa B subunit 1	Homo sapiens	84-93
32595742-9	2020	Conclusion: Curcumol may be one of the mechanisms of antihepatic fibrosis by inhibiting the activity of the NF-kappaB signaling pathway and increasing the fenestrae of LSECs.	curcumol	12-20	nuclear factor kappa B subunit 1	Homo sapiens	108-117
31926937-0	2020	Curcumol enhances the sensitivity of doxorubicin in triple-negative breast cancer via regulating the miR-181b-2-3p-ABCC3 axis.	curcumol	0-8	ATP binding cassette subfamily C member 3	Homo sapiens	115-120
31926937-11	2020	Furthermore, we found that NFAT1 could be activated by curcumol.	curcumol	55-63	nuclear factor of activated T cells 2	Homo sapiens	27-32
31926937-13	2020	Finally, using PDX models, we identified that curcumol could enhance sensitivity to doxorubicin to suppress tumor growth by the miR-181b-2-3p-ABCC3 axis in vivo.	curcumol	46-54	microRNA 181b-2	Homo sapiens	128-138
31926937-13	2020	Finally, using PDX models, we identified that curcumol could enhance sensitivity to doxorubicin to suppress tumor growth by the miR-181b-2-3p-ABCC3 axis in vivo.	curcumol	46-54	ATP binding cassette subfamily C member 3	Homo sapiens	142-147
32194780-0	2020	Curcumol inhibits the proliferation and metastasis of melanoma via the miR-152-3p/PI3K/AKT and ERK/NF-kappaB signaling pathways.	curcumol	0-8	thymoma viral proto-oncogene 1	Mus musculus	87-90
32119185-0	2020	Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis-PROX1-HIF-1alpha in liver fibrosis.	curcumol	0-8	prospero homeobox 1	Mus musculus	87-92
32119185-0	2020	Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis-PROX1-HIF-1alpha in liver fibrosis.	curcumol	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	93-103
32119185-4	2020	RESULTS: We found that curcumol inhibited angiogenic properties through regulating their upstream mediator hypoxia-inducible factor-1alpha (HIF-1alpha).	curcumol	23-31	hypoxia inducible factor 1, alpha subunit	Mus musculus	107-138
32119185-4	2020	RESULTS: We found that curcumol inhibited angiogenic properties through regulating their upstream mediator hypoxia-inducible factor-1alpha (HIF-1alpha).	curcumol	23-31	hypoxia inducible factor 1, alpha subunit	Mus musculus	140-150
32119185-8	2020	Besides, curcumol was found to ameliorate liver fibrosis and sinusoid angiogenesis via hedgehog pathway in carbon tetrachloride (CCl4 ) induced liver fibrotic mice.	curcumol	9-17	chemokine (C-C motif) ligand 4	Mus musculus	129-133
32194780-0	2020	Curcumol inhibits the proliferation and metastasis of melanoma via the miR-152-3p/PI3K/AKT and ERK/NF-kappaB signaling pathways.	curcumol	0-8	mitogen-activated protein kinase 1	Mus musculus	95-98
32194780-6	2020	Curcumol upregulated the expression of E-cadherin and downregulated the expression of N-cadherin, MMP2 and MMP9 in mouse melanoma B16 cell.	curcumol	0-8	cadherin 1	Mus musculus	39-49
32194780-6	2020	Curcumol upregulated the expression of E-cadherin and downregulated the expression of N-cadherin, MMP2 and MMP9 in mouse melanoma B16 cell.	curcumol	0-8	cadherin 2	Mus musculus	86-96
32194780-6	2020	Curcumol upregulated the expression of E-cadherin and downregulated the expression of N-cadherin, MMP2 and MMP9 in mouse melanoma B16 cell.	curcumol	0-8	matrix metallopeptidase 2	Mus musculus	98-102
32194780-6	2020	Curcumol upregulated the expression of E-cadherin and downregulated the expression of N-cadherin, MMP2 and MMP9 in mouse melanoma B16 cell.	curcumol	0-8	matrix metallopeptidase 9	Mus musculus	107-111
32194780-7	2020	Western blot analysis revealed that curcumol reduced the translocation of p65 to the nucleus and decreased p-ERK.	curcumol	36-44	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	74-77
32194780-7	2020	Western blot analysis revealed that curcumol reduced the translocation of p65 to the nucleus and decreased p-ERK.	curcumol	36-44	mitogen-activated protein kinase 1	Mus musculus	109-112
32194780-8	2020	Furthermore, curcumol attenuated c-MET, P13K and p-AKT protein expression and upregulated miR-152-3p gene expression.	curcumol	13-21	met proto-oncogene	Mus musculus	33-38
32194780-10	2020	Reduced expression of miR-152-3p partially attenuated the effect of curcumol on mouse melanoma B16 cell proliferation and migration.	curcumol	68-76	microRNA 152	Mus musculus	22-29
32194780-11	2020	The decrease in c-MET, P13K and p-AKT protein expression following curcumol treatment in mouse melanoma B16 cells was notably attenuated by the miR-152-3p inhibitor.	curcumol	67-75	met proto-oncogene	Mus musculus	16-21
32194780-12	2020	Taken together, our findings suggested that curcumol attenuated melanoma progression and concomitantly suppressed ERK/NF-kappaB signaling and promoted miR-152-3p expression to inactivate the c-MET/PI3K/AKT signaling pathway.	curcumol	44-52	mitogen-activated protein kinase 1	Mus musculus	114-117
32194780-12	2020	Taken together, our findings suggested that curcumol attenuated melanoma progression and concomitantly suppressed ERK/NF-kappaB signaling and promoted miR-152-3p expression to inactivate the c-MET/PI3K/AKT signaling pathway.	curcumol	44-52	met proto-oncogene	Mus musculus	191-196
32194780-12	2020	Taken together, our findings suggested that curcumol attenuated melanoma progression and concomitantly suppressed ERK/NF-kappaB signaling and promoted miR-152-3p expression to inactivate the c-MET/PI3K/AKT signaling pathway.	curcumol	44-52	thymoma viral proto-oncogene 1	Mus musculus	202-205
31193808-4	2019	In bioinformatic findings, the data of ingenuity pathway analysis (IPA) delineated that curcumol exerted anti-IC benefits through regulating multipronged signaling pathways, including tyrosine protein kinase-2 (PTK2) pathway.	curcumol	88-96	protein tyrosine kinase 2	Homo sapiens	211-215
31360103-5	2019	Curcumol has been documented as potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-kappaB which are generally deregulated in several cancers.	curcumol	0-8	mitogen-activated protein kinase 1	Homo sapiens	130-133
31360103-5	2019	Curcumol has been documented as potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-kappaB which are generally deregulated in several cancers.	curcumol	0-8	AKT serine/threonine kinase 1	Homo sapiens	140-143
31360103-5	2019	Curcumol has been documented as potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-kappaB which are generally deregulated in several cancers.	curcumol	0-8	nuclear factor kappa B subunit 1	Homo sapiens	148-157
31193808-9	2019	Interestingly, curcumol-treated IC mice showed that intracellular expressions of PTK2, p-PTK2Tyr397 in bladder samples were reduced, accompanied with lowered blood inflammatory cytokines of interleukin 6 (IL-6), TNF-alpha.	curcumol	15-23	PTK2 protein tyrosine kinase 2	Mus musculus	81-85
31193808-9	2019	Interestingly, curcumol-treated IC mice showed that intracellular expressions of PTK2, p-PTK2Tyr397 in bladder samples were reduced, accompanied with lowered blood inflammatory cytokines of interleukin 6 (IL-6), TNF-alpha.	curcumol	15-23	interleukin 6	Mus musculus	190-203
31193808-9	2019	Interestingly, curcumol-treated IC mice showed that intracellular expressions of PTK2, p-PTK2Tyr397 in bladder samples were reduced, accompanied with lowered blood inflammatory cytokines of interleukin 6 (IL-6), TNF-alpha.	curcumol	15-23	interleukin 6	Mus musculus	205-209
31193808-9	2019	Interestingly, curcumol-treated IC mice showed that intracellular expressions of PTK2, p-PTK2Tyr397 in bladder samples were reduced, accompanied with lowered blood inflammatory cytokines of interleukin 6 (IL-6), TNF-alpha.	curcumol	15-23	tumor necrosis factor	Mus musculus	212-221
31193808-10	2019	In conclusion, the current bioinformatic data and preliminary findings unravel that the predominant targets of curcumol against IC may be the potential biological markers for screening and treating IC, such as PTK2 molecule.	curcumol	111-119	protein tyrosine kinase 2	Homo sapiens	210-214
30811964-7	2019	SIGNIFICANCE: Our research demonstrated that curcumol reduced the proliferation of CRC cells through PTEN/PI3K/Akt by targeting miR-21 and miR-21 could be a target molecule of curcumol for CRC treatment.	curcumol	45-53	microRNA 21	Homo sapiens	128-134
30658235-0	2019	Orobanone analogues from acid-promoted aromatization rearrangement of curcumol inhibit hypoxia-inducible factor-1 (HIF-1) in cell-based reporter assays.	curcumol	70-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-113
30658235-0	2019	Orobanone analogues from acid-promoted aromatization rearrangement of curcumol inhibit hypoxia-inducible factor-1 (HIF-1) in cell-based reporter assays.	curcumol	70-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-120
30811964-0	2019	Curcumol inhibits colorectal cancer proliferation by targeting miR-21 and modulated PTEN/PI3K/Akt pathways.	curcumol	0-8	microRNA 21	Homo sapiens	63-69
30811964-7	2019	SIGNIFICANCE: Our research demonstrated that curcumol reduced the proliferation of CRC cells through PTEN/PI3K/Akt by targeting miR-21 and miR-21 could be a target molecule of curcumol for CRC treatment.	curcumol	45-53	microRNA 21	Homo sapiens	139-145
30811964-0	2019	Curcumol inhibits colorectal cancer proliferation by targeting miR-21 and modulated PTEN/PI3K/Akt pathways.	curcumol	0-8	phosphatase and tensin homolog	Homo sapiens	84-88
30811964-0	2019	Curcumol inhibits colorectal cancer proliferation by targeting miR-21 and modulated PTEN/PI3K/Akt pathways.	curcumol	0-8	AKT serine/threonine kinase 1	Homo sapiens	94-97
30811964-7	2019	SIGNIFICANCE: Our research demonstrated that curcumol reduced the proliferation of CRC cells through PTEN/PI3K/Akt by targeting miR-21 and miR-21 could be a target molecule of curcumol for CRC treatment.	curcumol	176-184	AKT serine/threonine kinase 1	Homo sapiens	111-114
30811964-1	2019	AIMS: The purpose of this study was to demonstrate how curcumol affected the expression of miR-21 and whether its effects on miR-21 was associated with the activation of PTEN/PI3K/Akt pathways in CRC cells.	curcumol	55-63	microRNA 21	Homo sapiens	91-97
30811964-7	2019	SIGNIFICANCE: Our research demonstrated that curcumol reduced the proliferation of CRC cells through PTEN/PI3K/Akt by targeting miR-21 and miR-21 could be a target molecule of curcumol for CRC treatment.	curcumol	176-184	microRNA 21	Homo sapiens	128-134
30811964-3	2019	Q-PCR and western blot analysis were employed to test the role of miR-21 in the inhibition of curcumol on proliferation and PTEN/PI3K/Akt pathways of CRC cells.	curcumol	94-102	microRNA 21	Homo sapiens	66-72
30811964-4	2019	KEY FINDINGS: We found that curcumol effectively inhibited CRC cells from proliferating via the PTEN/PI3K/Akt pathways and reduced expression of miR-21 both in vitro and in vivo.	curcumol	28-36	phosphatase and tensin homolog	Homo sapiens	96-100
30811964-7	2019	SIGNIFICANCE: Our research demonstrated that curcumol reduced the proliferation of CRC cells through PTEN/PI3K/Akt by targeting miR-21 and miR-21 could be a target molecule of curcumol for CRC treatment.	curcumol	176-184	microRNA 21	Homo sapiens	139-145
30811964-4	2019	KEY FINDINGS: We found that curcumol effectively inhibited CRC cells from proliferating via the PTEN/PI3K/Akt pathways and reduced expression of miR-21 both in vitro and in vivo.	curcumol	28-36	AKT serine/threonine kinase 1	Homo sapiens	106-109
30811964-4	2019	KEY FINDINGS: We found that curcumol effectively inhibited CRC cells from proliferating via the PTEN/PI3K/Akt pathways and reduced expression of miR-21 both in vitro and in vivo.	curcumol	28-36	microRNA 21	Homo sapiens	145-151
30237126-0	2018	Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.	curcumol	0-8	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	17-22
30811964-7	2019	SIGNIFICANCE: Our research demonstrated that curcumol reduced the proliferation of CRC cells through PTEN/PI3K/Akt by targeting miR-21 and miR-21 could be a target molecule of curcumol for CRC treatment.	curcumol	45-53	phosphatase and tensin homolog	Homo sapiens	101-105
30811964-7	2019	SIGNIFICANCE: Our research demonstrated that curcumol reduced the proliferation of CRC cells through PTEN/PI3K/Akt by targeting miR-21 and miR-21 could be a target molecule of curcumol for CRC treatment.	curcumol	45-53	AKT serine/threonine kinase 1	Homo sapiens	111-114
30069933-0	2018	Curcumol induces cell cycle arrest and apoptosis by inhibiting IGF-1R/PI3K/Akt signaling pathway in human nasopharyngeal carcinoma CNE-2 cells.	curcumol	0-8	insulin like growth factor 1 receptor	Homo sapiens	63-69
30069933-0	2018	Curcumol induces cell cycle arrest and apoptosis by inhibiting IGF-1R/PI3K/Akt signaling pathway in human nasopharyngeal carcinoma CNE-2 cells.	curcumol	0-8	AKT serine/threonine kinase 1	Homo sapiens	75-78
30069933-3	2018	Recently, our team clarified that curcumol inhibited colorectal cancer cells" growth partially through insulin-like growth factor 1 receptor (IGF-1R) pathway.	curcumol	34-42	insulin like growth factor 1 receptor	Homo sapiens	103-140
30069933-3	2018	Recently, our team clarified that curcumol inhibited colorectal cancer cells" growth partially through insulin-like growth factor 1 receptor (IGF-1R) pathway.	curcumol	34-42	insulin like growth factor 1 receptor	Homo sapiens	142-148
30069933-4	2018	Given the key importance of IGF-1R pathway in tumorigenesis, we want to explore whether curcumol effects on nasopharyngeal carcinoma (NPC) cells relates to IGF-1R and its downstream pathway inactivation.	curcumol	88-96	insulin like growth factor 1 receptor	Homo sapiens	156-162
30069933-5	2018	In this study, we found that curcumol inhibited IGF-1R and p-Akt expression in a dose- and time-dependent way.	curcumol	29-37	insulin like growth factor 1 receptor	Homo sapiens	48-54
30069933-5	2018	In this study, we found that curcumol inhibited IGF-1R and p-Akt expression in a dose- and time-dependent way.	curcumol	29-37	AKT serine/threonine kinase 1	Homo sapiens	61-64
30069933-7	2018	Moreover, curcumol"s effect on CNE-2 cells was partly eliminated by IGF-1R"s agonist IGF-1.	curcumol	10-18	insulin like growth factor 1 receptor	Homo sapiens	68-74
30069933-7	2018	Moreover, curcumol"s effect on CNE-2 cells was partly eliminated by IGF-1R"s agonist IGF-1.	curcumol	10-18	insulin like growth factor 1	Homo sapiens	68-73
30069933-8	2018	In conclusion, our findings indicated that the inhibitory effect of curcumol on proliferation of NPC cells is related to the inhibition of IGF-1R and its downstream PI3K/Akt/GSK-3beta pathway.	curcumol	68-76	insulin like growth factor 1 receptor	Homo sapiens	139-145
30069933-8	2018	In conclusion, our findings indicated that the inhibitory effect of curcumol on proliferation of NPC cells is related to the inhibition of IGF-1R and its downstream PI3K/Akt/GSK-3beta pathway.	curcumol	68-76	AKT serine/threonine kinase 1	Homo sapiens	170-173
30069933-8	2018	In conclusion, our findings indicated that the inhibitory effect of curcumol on proliferation of NPC cells is related to the inhibition of IGF-1R and its downstream PI3K/Akt/GSK-3beta pathway.	curcumol	68-76	glycogen synthase kinase 3 beta	Homo sapiens	174-183
30237126-12	2018	In summary, our study results reveal the molecular mechanism of curcumol-induced HSC necroptosis, and suggest a potential clinical use of curcumol-targeted RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling for the treatment of hepatic fibrosis.	curcumol	64-72	mitogen-activated protein kinase 8	Mus musculus	202-208
30237126-12	2018	In summary, our study results reveal the molecular mechanism of curcumol-induced HSC necroptosis, and suggest a potential clinical use of curcumol-targeted RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling for the treatment of hepatic fibrosis.	curcumol	138-146	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	156-161
30237126-12	2018	In summary, our study results reveal the molecular mechanism of curcumol-induced HSC necroptosis, and suggest a potential clinical use of curcumol-targeted RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling for the treatment of hepatic fibrosis.	curcumol	138-146	receptor-interacting serine-threonine kinase 3	Mus musculus	162-167
30237126-12	2018	In summary, our study results reveal the molecular mechanism of curcumol-induced HSC necroptosis, and suggest a potential clinical use of curcumol-targeted RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling for the treatment of hepatic fibrosis.	curcumol	138-146	mitogen-activated protein kinase 8	Mus musculus	202-208
30237126-0	2018	Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.	curcumol	0-8	receptor-interacting serine-threonine kinase 3	Mus musculus	23-28
30237126-0	2018	Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.	curcumol	0-8	mitogen-activated protein kinase 8	Mus musculus	63-69
30237126-4	2018	We found that curcumol ameliorated the carbon tetrachloride (CCl4)-induced mice liver fibrosis and suppressed HSC proliferation and activation, which was associated with regulating HSC necroptosis through increasing the phosphorylation of receptor-interacting protein kinase 1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3).	curcumol	14-22	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	239-276
30237126-4	2018	We found that curcumol ameliorated the carbon tetrachloride (CCl4)-induced mice liver fibrosis and suppressed HSC proliferation and activation, which was associated with regulating HSC necroptosis through increasing the phosphorylation of receptor-interacting protein kinase 1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3).	curcumol	14-22	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	278-283
30237126-4	2018	We found that curcumol ameliorated the carbon tetrachloride (CCl4)-induced mice liver fibrosis and suppressed HSC proliferation and activation, which was associated with regulating HSC necroptosis through increasing the phosphorylation of receptor-interacting protein kinase 1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3).	curcumol	14-22	receptor-interacting serine-threonine kinase 3	Mus musculus	286-323
30237126-4	2018	We found that curcumol ameliorated the carbon tetrachloride (CCl4)-induced mice liver fibrosis and suppressed HSC proliferation and activation, which was associated with regulating HSC necroptosis through increasing the phosphorylation of receptor-interacting protein kinase 1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3).	curcumol	14-22	receptor-interacting serine-threonine kinase 3	Mus musculus	325-330
30237126-5	2018	Moreover, curcumol promoted the migration of RIPK1 and RIPK3 into necrosome in HSCs.	curcumol	10-18	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	45-50
30237126-5	2018	Moreover, curcumol promoted the migration of RIPK1 and RIPK3 into necrosome in HSCs.	curcumol	10-18	receptor-interacting serine-threonine kinase 3	Mus musculus	55-60
30237126-6	2018	RIPK3 depletion impaired the anti-fibrotic effect of curcumol.	curcumol	53-61	receptor-interacting serine-threonine kinase 3	Mus musculus	0-5
30237126-7	2018	Importantly, we showed that curcumol-induced RIPK3 up-regulation significantly increased mitochondrial reactive oxygen species (ROS) production and mitochondrial depolarization.	curcumol	28-36	receptor-interacting serine-threonine kinase 3	Mus musculus	45-50
30237126-9	2018	In addition, our study also identified that the activation of c-Jun N-terminal kinase1/2 (JNK1/2) was regulated by RIPK3, which mediated curcumol-induced ROS production.	curcumol	137-145	mitogen-activated protein kinase 8	Mus musculus	62-88
30237126-9	2018	In addition, our study also identified that the activation of c-Jun N-terminal kinase1/2 (JNK1/2) was regulated by RIPK3, which mediated curcumol-induced ROS production.	curcumol	137-145	mitogen-activated protein kinase 8	Mus musculus	90-96
30237126-9	2018	In addition, our study also identified that the activation of c-Jun N-terminal kinase1/2 (JNK1/2) was regulated by RIPK3, which mediated curcumol-induced ROS production.	curcumol	137-145	receptor-interacting serine-threonine kinase 3	Mus musculus	115-120
30237126-11	2018	The use of specific JNK1/2 inhibitor (SP600125) resulted in the suppression of curcumol-induced ROS production and mitochondrial depolarization, which in turn, contributed to the inhibition of curcumol-triggered necroptosis.	curcumol	79-87	mitogen-activated protein kinase 8	Mus musculus	20-26
30237126-11	2018	The use of specific JNK1/2 inhibitor (SP600125) resulted in the suppression of curcumol-induced ROS production and mitochondrial depolarization, which in turn, contributed to the inhibition of curcumol-triggered necroptosis.	curcumol	193-201	mitogen-activated protein kinase 8	Mus musculus	20-26
30237126-12	2018	In summary, our study results reveal the molecular mechanism of curcumol-induced HSC necroptosis, and suggest a potential clinical use of curcumol-targeted RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling for the treatment of hepatic fibrosis.	curcumol	64-72	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	156-161
30237126-12	2018	In summary, our study results reveal the molecular mechanism of curcumol-induced HSC necroptosis, and suggest a potential clinical use of curcumol-targeted RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling for the treatment of hepatic fibrosis.	curcumol	64-72	receptor-interacting serine-threonine kinase 3	Mus musculus	162-167
29852354-0	2018	Anti-proliferative benefit of curcumol on human bladder cancer cells via inactivating EZH2 effector.	curcumol	30-38	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	86-90
29852354-9	2018	In addition, suppression of EZH2 enhanced the inhibitory effects of curcumol on cell growth and colony formation and increased curcumol-induced apoptosis.	curcumol	68-76	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	28-32
29852354-9	2018	In addition, suppression of EZH2 enhanced the inhibitory effects of curcumol on cell growth and colony formation and increased curcumol-induced apoptosis.	curcumol	127-135	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	28-32
29852354-10	2018	Conversely, enforced expression of EZH2 ameliorated the inhibitory effects of curcumol on cell growth and colony formation and decreased curcumol-induced apoptosis in EJ and T24 cells.	curcumol	78-86	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	35-39
29852354-10	2018	Conversely, enforced expression of EZH2 ameliorated the inhibitory effects of curcumol on cell growth and colony formation and decreased curcumol-induced apoptosis in EJ and T24 cells.	curcumol	137-145	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	35-39
29852354-13	2018	Our data indicate that curcumol inhibits proliferation and induces apoptosis by targeting EZH2 and modulating the mitochondrial apoptosis pathway.	curcumol	23-31	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	90-94
29620189-0	2018	Curcumol attenuates epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via TGF-beta1.	curcumol	0-8	transforming growth factor beta 1	Homo sapiens	92-101
29684682-0	2018	Identification and validation nucleolin as a target of curcumol in nasopharyngeal carcinoma cells.	curcumol	55-63	nucleolin	Homo sapiens	30-39
29684682-6	2018	Chemical proteomics capturing uncovered that NCL is a target of curcumol in NPC cells, Molecular docking showed that curcumol bound to NCL with an -7.8 kcal/mol binding free energy.	curcumol	64-72	nucleolin	Homo sapiens	45-48
29684682-6	2018	Chemical proteomics capturing uncovered that NCL is a target of curcumol in NPC cells, Molecular docking showed that curcumol bound to NCL with an -7.8 kcal/mol binding free energy.	curcumol	64-72	nucleolin	Homo sapiens	135-138
29684682-6	2018	Chemical proteomics capturing uncovered that NCL is a target of curcumol in NPC cells, Molecular docking showed that curcumol bound to NCL with an -7.8 kcal/mol binding free energy.	curcumol	117-125	nucleolin	Homo sapiens	45-48
29684682-6	2018	Chemical proteomics capturing uncovered that NCL is a target of curcumol in NPC cells, Molecular docking showed that curcumol bound to NCL with an -7.8 kcal/mol binding free energy.	curcumol	117-125	nucleolin	Homo sapiens	135-138
29684682-7	2018	Cell function analysis found that curcumol"s treatment leads to a degradation of NCL in NPC cells, and it showed slight effects on NP69 cells.	curcumol	34-42	nucleolin	Homo sapiens	81-84
29684682-8	2018	In conclusion, our results providing evidences that NCL is a target protein of curcumol.	curcumol	79-87	nucleolin	Homo sapiens	52-55
29684682-9	2018	We revealed that the anti-cancer effects of curcumol in NPC cells are mediated, at least in part, by NCL inhibition.	curcumol	44-52	nucleolin	Homo sapiens	101-104
29684682-15	2018	Curcumol, has shown effective inhibition on Nasopharyngeal Carcinoma (NPC) Cells, interacted with NCL and then initiated the anti-tumor biological effect.	curcumol	0-8	nucleolin	Homo sapiens	98-101
29620189-11	2018	Curcumol also regulated the secretion of protein markers in the serum that were associated with EMT and TGF-beta1 in the 5-8F xenograft mouse model.	curcumol	0-8	transforming growth factor, beta 1	Mus musculus	104-113
29620189-12	2018	Thus, the results indicated that Curcumol induced TGF-beta1-mediated EMT arrest by regulating E-cadherin and N-cadherin, which may prevent further development of NPC.	curcumol	33-41	transforming growth factor beta 1	Homo sapiens	50-59
29620189-12	2018	Thus, the results indicated that Curcumol induced TGF-beta1-mediated EMT arrest by regulating E-cadherin and N-cadherin, which may prevent further development of NPC.	curcumol	33-41	cadherin 1	Homo sapiens	94-104
29620189-12	2018	Thus, the results indicated that Curcumol induced TGF-beta1-mediated EMT arrest by regulating E-cadherin and N-cadherin, which may prevent further development of NPC.	curcumol	33-41	cadherin 2	Homo sapiens	109-119
29615928-0	2018	Curcumol Exerts Anticancer Effect in Cholangiocarcinoma Cells via Down-Regulating CDKL3.	curcumol	0-8	cyclin dependent kinase like 3	Homo sapiens	82-87
29615928-4	2018	In our current research, we tested the effect of curcumol in cholangiocarcinoma cells, and using two-dimensional electrophoresis, proteomics and bioinformatics, we identified cyclin-dependent kinase like 3 (CDKL3) as a potential target for curcumol.	curcumol	49-57	cyclin dependent kinase like 3	Homo sapiens	175-205
29615928-4	2018	In our current research, we tested the effect of curcumol in cholangiocarcinoma cells, and using two-dimensional electrophoresis, proteomics and bioinformatics, we identified cyclin-dependent kinase like 3 (CDKL3) as a potential target for curcumol.	curcumol	49-57	cyclin dependent kinase like 3	Homo sapiens	207-212
29615928-4	2018	In our current research, we tested the effect of curcumol in cholangiocarcinoma cells, and using two-dimensional electrophoresis, proteomics and bioinformatics, we identified cyclin-dependent kinase like 3 (CDKL3) as a potential target for curcumol.	curcumol	240-248	cyclin dependent kinase like 3	Homo sapiens	175-205
29615928-4	2018	In our current research, we tested the effect of curcumol in cholangiocarcinoma cells, and using two-dimensional electrophoresis, proteomics and bioinformatics, we identified cyclin-dependent kinase like 3 (CDKL3) as a potential target for curcumol.	curcumol	240-248	cyclin dependent kinase like 3	Homo sapiens	207-212
29615928-7	2018	These effects could be largely attributed to the inhibition of CDKL3 by curcumol.	curcumol	72-80	cyclin dependent kinase like 3	Homo sapiens	63-68
29615928-9	2018	Given the high level of CDKL3 expression in human cholangiocarcinoma tissues and cell lines, we speculated that CDKL3 may constitute a potential biological target for curcumol in cholangiocarcinoma.	curcumol	167-175	cyclin dependent kinase like 3	Homo sapiens	24-29
29615928-9	2018	Given the high level of CDKL3 expression in human cholangiocarcinoma tissues and cell lines, we speculated that CDKL3 may constitute a potential biological target for curcumol in cholangiocarcinoma.	curcumol	167-175	cyclin dependent kinase like 3	Homo sapiens	112-117
28684297-0	2018	Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3beta/cyclin D1 pathway.	curcumol	0-8	AKT serine/threonine kinase 1	Homo sapiens	89-92
29363667-0	2018	Curcumol Controls Choriocarcinoma Stem-Like Cells Self-Renewal via Repression of DNA Methyltransferase (DNMT)- and Histone Deacetylase (HDAC)-Mediated Epigenetic Regulation.	curcumol	0-8	DNA methyltransferase 1	Homo sapiens	81-102
29363667-0	2018	Curcumol Controls Choriocarcinoma Stem-Like Cells Self-Renewal via Repression of DNA Methyltransferase (DNMT)- and Histone Deacetylase (HDAC)-Mediated Epigenetic Regulation.	curcumol	0-8	DNA methyltransferase 1	Homo sapiens	104-108
29363667-0	2018	Curcumol Controls Choriocarcinoma Stem-Like Cells Self-Renewal via Repression of DNA Methyltransferase (DNMT)- and Histone Deacetylase (HDAC)-Mediated Epigenetic Regulation.	curcumol	0-8	histone deacetylase 9	Homo sapiens	115-134
29363667-0	2018	Curcumol Controls Choriocarcinoma Stem-Like Cells Self-Renewal via Repression of DNA Methyltransferase (DNMT)- and Histone Deacetylase (HDAC)-Mediated Epigenetic Regulation.	curcumol	0-8	histone deacetylase 9	Homo sapiens	136-140
28684297-0	2018	Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3beta/cyclin D1 pathway.	curcumol	0-8	glycogen synthase kinase 3 beta	Homo sapiens	94-102
28684297-0	2018	Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3beta/cyclin D1 pathway.	curcumol	0-8	cyclin D1	Homo sapiens	103-112
28684297-13	2018	RT-qPCR and Western blot data showed that curcumol enhanced the expression of GSK3beta, P27, p21 and P16, and decreased the levels of PI3K, phosphorylated Akt (p-Akt), cyclin D1, CDK4, cyclin E and CDK2.	curcumol	42-50	glycogen synthase kinase 3 beta	Homo sapiens	78-86
28684297-13	2018	RT-qPCR and Western blot data showed that curcumol enhanced the expression of GSK3beta, P27, p21 and P16, and decreased the levels of PI3K, phosphorylated Akt (p-Akt), cyclin D1, CDK4, cyclin E and CDK2.	curcumol	42-50	dynactin subunit 6	Homo sapiens	88-91
28684297-13	2018	RT-qPCR and Western blot data showed that curcumol enhanced the expression of GSK3beta, P27, p21 and P16, and decreased the levels of PI3K, phosphorylated Akt (p-Akt), cyclin D1, CDK4, cyclin E and CDK2.	curcumol	42-50	H3 histone pseudogene 16	Homo sapiens	93-96
28684297-13	2018	RT-qPCR and Western blot data showed that curcumol enhanced the expression of GSK3beta, P27, p21 and P16, and decreased the levels of PI3K, phosphorylated Akt (p-Akt), cyclin D1, CDK4, cyclin E and CDK2.	curcumol	42-50	cyclin dependent kinase inhibitor 2A	Homo sapiens	101-104
28684297-13	2018	RT-qPCR and Western blot data showed that curcumol enhanced the expression of GSK3beta, P27, p21 and P16, and decreased the levels of PI3K, phosphorylated Akt (p-Akt), cyclin D1, CDK4, cyclin E and CDK2.	curcumol	42-50	AKT serine/threonine kinase 1	Homo sapiens	155-158
28684297-13	2018	RT-qPCR and Western blot data showed that curcumol enhanced the expression of GSK3beta, P27, p21 and P16, and decreased the levels of PI3K, phosphorylated Akt (p-Akt), cyclin D1, CDK4, cyclin E and CDK2.	curcumol	42-50	AKT serine/threonine kinase 1	Homo sapiens	162-165
28684297-13	2018	RT-qPCR and Western blot data showed that curcumol enhanced the expression of GSK3beta, P27, p21 and P16, and decreased the levels of PI3K, phosphorylated Akt (p-Akt), cyclin D1, CDK4, cyclin E and CDK2.	curcumol	42-50	cyclin D1	Homo sapiens	168-177
28684297-13	2018	RT-qPCR and Western blot data showed that curcumol enhanced the expression of GSK3beta, P27, p21 and P16, and decreased the levels of PI3K, phosphorylated Akt (p-Akt), cyclin D1, CDK4, cyclin E and CDK2.	curcumol	42-50	cyclin dependent kinase 4	Homo sapiens	179-183
28684297-13	2018	RT-qPCR and Western blot data showed that curcumol enhanced the expression of GSK3beta, P27, p21 and P16, and decreased the levels of PI3K, phosphorylated Akt (p-Akt), cyclin D1, CDK4, cyclin E and CDK2.	curcumol	42-50	cyclin dependent kinase 2	Homo sapiens	198-202
28684297-15	2018	Besides, curcumol also prevented the growth of human colon cancer cells xenografts in nude mouse, accompanied by the reduction of PI3K, Akt, cyclin D1, CDK4, cycln E and significant increase of GSK3beta.	curcumol	9-17	thymoma viral proto-oncogene 1	Mus musculus	136-139
28684297-15	2018	Besides, curcumol also prevented the growth of human colon cancer cells xenografts in nude mouse, accompanied by the reduction of PI3K, Akt, cyclin D1, CDK4, cycln E and significant increase of GSK3beta.	curcumol	9-17	cyclin D1	Mus musculus	141-150
28684297-15	2018	Besides, curcumol also prevented the growth of human colon cancer cells xenografts in nude mouse, accompanied by the reduction of PI3K, Akt, cyclin D1, CDK4, cycln E and significant increase of GSK3beta.	curcumol	9-17	cyclin-dependent kinase 4	Mus musculus	152-156
28684297-15	2018	Besides, curcumol also prevented the growth of human colon cancer cells xenografts in nude mouse, accompanied by the reduction of PI3K, Akt, cyclin D1, CDK4, cycln E and significant increase of GSK3beta.	curcumol	9-17	glycogen synthase kinase 3 beta	Mus musculus	194-202
28684297-16	2018	CONCLUSIONS: Curcumol caused cell cycle arrest at the G0/G1 phase by ROS production and Akt/ GSK3beta/cyclin D1 pathways inactivation, indicating the potential of curcumol in the prevention of colon cancer carcinogenesis.	curcumol	13-21	AKT serine/threonine kinase 1	Homo sapiens	88-91
28684297-16	2018	CONCLUSIONS: Curcumol caused cell cycle arrest at the G0/G1 phase by ROS production and Akt/ GSK3beta/cyclin D1 pathways inactivation, indicating the potential of curcumol in the prevention of colon cancer carcinogenesis.	curcumol	13-21	glycogen synthase kinase 3 beta	Homo sapiens	93-101
28684297-16	2018	CONCLUSIONS: Curcumol caused cell cycle arrest at the G0/G1 phase by ROS production and Akt/ GSK3beta/cyclin D1 pathways inactivation, indicating the potential of curcumol in the prevention of colon cancer carcinogenesis.	curcumol	13-21	cyclin D1	Homo sapiens	102-111
28684297-16	2018	CONCLUSIONS: Curcumol caused cell cycle arrest at the G0/G1 phase by ROS production and Akt/ GSK3beta/cyclin D1 pathways inactivation, indicating the potential of curcumol in the prevention of colon cancer carcinogenesis.	curcumol	163-171	glycogen synthase kinase 3 beta	Homo sapiens	93-101
28684297-16	2018	CONCLUSIONS: Curcumol caused cell cycle arrest at the G0/G1 phase by ROS production and Akt/ GSK3beta/cyclin D1 pathways inactivation, indicating the potential of curcumol in the prevention of colon cancer carcinogenesis.	curcumol	163-171	cyclin D1	Homo sapiens	102-111
29151904-0	2017	Inhibition of autophagy attenuated curcumol-induced apoptosis in MG-63 human osteosarcoma cells via Janus kinase signaling pathway.	curcumol	35-43	mitogen-activated protein kinase 8	Homo sapiens	100-112
29383179-6	2017	Additionally, either celecoxib alone or in combination with curcumol inhibited NSCLC cell migration and invasion by suppressing FAK and matrix metalloproteinase-9 activities.	curcumol	60-68	protein tyrosine kinase 2	Homo sapiens	128-131
29383179-6	2017	Additionally, either celecoxib alone or in combination with curcumol inhibited NSCLC cell migration and invasion by suppressing FAK and matrix metalloproteinase-9 activities.	curcumol	60-68	matrix metallopeptidase 9	Homo sapiens	136-162
29151904-12	2017	Of note, pretreatment with the JNK inhibitor, SP600125, decreased the rates of autophagy and apoptosis, suggesting a crucial role served by the JNK signaling pathway in the activation of autophagy by curcumol.	curcumol	200-208	mitogen-activated protein kinase 8	Homo sapiens	31-34
29151904-12	2017	Of note, pretreatment with the JNK inhibitor, SP600125, decreased the rates of autophagy and apoptosis, suggesting a crucial role served by the JNK signaling pathway in the activation of autophagy by curcumol.	curcumol	200-208	mitogen-activated protein kinase 8	Homo sapiens	144-147
29151904-13	2017	Taken together, the results of the present study suggested that activation of the JNK signaling pathway was involved in curcumol-induced autophagy.	curcumol	120-128	mitogen-activated protein kinase 8	Homo sapiens	82-85
29039582-0	2017	Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1.	curcumol	0-8	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	98-102
29039582-5	2017	The results of the Annexin V/propidium iodide (PI) staining followed by fluorescence activated cell sorting (FACS) analysis demonstrated that the cell cycle was arrested in the G2/M phase by curcumol.	curcumol	191-199	annexin A5	Homo sapiens	19-28
29039582-6	2017	Annexin V-FITC/PI double staining followed by FACS analysis revealed that curcumol induced apoptosis of MGC-803 cells.	curcumol	74-82	annexin A5	Homo sapiens	0-9
29039582-9	2017	Furthermore, the downregulation of isocitrate dehydrogenase 1 (IDH1) was observed in the MGC-803 cells after being treated with curcumol as determined by western blotting and RT-qPCR.	curcumol	128-136	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	35-61
29039582-9	2017	Furthermore, the downregulation of isocitrate dehydrogenase 1 (IDH1) was observed in the MGC-803 cells after being treated with curcumol as determined by western blotting and RT-qPCR.	curcumol	128-136	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	63-67
29039582-10	2017	In conclusion, we elucidated the antitumor effect of curcumol on MGC-803 cells and the involved mechanisms related to the induction of apoptosis, the increase of ROS, the decrease of MMP and the downregulation of IDH1.	curcumol	53-61	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	213-217
29151904-11	2017	Compared with the curcumol treatment alone group, the GFP-LC3-transfected green fluorescence plasmids and the LC3II/LC3I levels in cells of the curcumol and chloroquine (CQ) treatment group were upregulated, and the apoptotic ratio was downregulated following pretreatment with autophagy inhibitor CQ for 1 h. Furthermore, curcumol treatment induced phosphorylation of the JNK signaling pathway.	curcumol	18-26	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	58-61
28436443-7	2017	Finally, mutations at the beta2 or gamma2 subunit predominantly eliminated modulation of recombinant GABAARs by curcumol and menthol, or diazepam, respectively.	curcumol	112-120	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	26-31
28693277-0	2017	Curcumol triggers apoptosis of p53 mutant triple-negative human breast cancer MDA-MB 231 cells via activation of p73 and PUMA.	curcumol	0-8	tumor protein p53	Homo sapiens	31-34
28693277-0	2017	Curcumol triggers apoptosis of p53 mutant triple-negative human breast cancer MDA-MB 231 cells via activation of p73 and PUMA.	curcumol	0-8	tumor protein p73	Homo sapiens	113-116
28693277-6	2017	The present study aimed to investigate the anticancer effects of curcumol in the human p53 mutant TNBC MDA-MB-231 cell line and its underlying mechanisms.	curcumol	65-73	tumor protein p53	Homo sapiens	87-90
28693277-12	2017	Curcumol treatment also resulted in the suppression of xenograft growth in vivo (100 or 200 microg/kg for 21 days), as well as G1 phase arrest and an apoptotic response, which were accompanied by the upregulation of p73 expression and the activation of the expression of p53 upregulated modulator of apoptosis (PUMA) and Bcl-2 antagonistic killer (Bak).	curcumol	0-8	tumor protein p73	Homo sapiens	216-219
28693277-12	2017	Curcumol treatment also resulted in the suppression of xenograft growth in vivo (100 or 200 microg/kg for 21 days), as well as G1 phase arrest and an apoptotic response, which were accompanied by the upregulation of p73 expression and the activation of the expression of p53 upregulated modulator of apoptosis (PUMA) and Bcl-2 antagonistic killer (Bak).	curcumol	0-8	tumor protein p53	Homo sapiens	271-274
28693277-14	2017	To the best of our knowledge, the present data demonstrate for the first time that curcumol inhibits the growth of MDA-MB-231 cells and triggers p53-independent apoptosis, which may be mediated by the p73-PUMA/Bak signaling pathway.	curcumol	83-91	tumor protein p53	Homo sapiens	145-148
28693277-14	2017	To the best of our knowledge, the present data demonstrate for the first time that curcumol inhibits the growth of MDA-MB-231 cells and triggers p53-independent apoptosis, which may be mediated by the p73-PUMA/Bak signaling pathway.	curcumol	83-91	tumor protein p73	Homo sapiens	201-204
28436443-7	2017	Finally, mutations at the beta2 or gamma2 subunit predominantly eliminated modulation of recombinant GABAARs by curcumol and menthol, or diazepam, respectively.	curcumol	112-120	tryptophanyl-tRNA synthetase 1	Homo sapiens	35-41
28345336-0	2017	Proteomic Identification of eEF1A1 as a Molecular Target of Curcumol for Suppressing Metastasis of MDA-MB-231 Cells.	curcumol	60-68	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	28-34
28345336-6	2017	Curcumol decreased eEF1A1 expression at both mRNA and protein levels.	curcumol	0-8	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	19-25
28345336-8	2017	Importantly, overexpression of eEF1A1 significantly reversed the inhibition of curcumol regarding the invasion and adhesion of MDA-MB-231 cells (p &lt; 0.05).	curcumol	79-87	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	31-37
28345336-9	2017	Together, our data suggest that eEF1A1 may be a potential molecular target underlying the antimetastatic effect of curcumol.	curcumol	115-123	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	32-38
28138126-0	2017	Curcumol Promotes Vascular Endothelial Growth Factor (VEGF)-Mediated Diabetic Wound Healing in Streptozotocin-Induced Hyperglycemic Rats.	curcumol	0-8	vascular endothelial growth factor A	Rattus norvegicus	18-52
28138126-0	2017	Curcumol Promotes Vascular Endothelial Growth Factor (VEGF)-Mediated Diabetic Wound Healing in Streptozotocin-Induced Hyperglycemic Rats.	curcumol	0-8	vascular endothelial growth factor A	Rattus norvegicus	54-58
28138126-13	2017	CONCLUSIONS Our analyses clearly suggested that the observed enhancement in wound healing as a result of curcumol administration was attributable to VEGF-mediated angiogenesis.	curcumol	105-113	vascular endothelial growth factor A	Rattus norvegicus	149-153
27819177-8	2016	Neural cell adhesion molecule (NCAM)/focal adhesion kinase (FAK) but not extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling was repressed by curcumol exposure in differentiated PC12 cells.	curcumol	156-164	neural cell adhesion molecule 1	Rattus norvegicus	0-29
27819177-8	2016	Neural cell adhesion molecule (NCAM)/focal adhesion kinase (FAK) but not extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling was repressed by curcumol exposure in differentiated PC12 cells.	curcumol	156-164	neural cell adhesion molecule 1	Rattus norvegicus	31-35
27819177-10	2016	These findings suggest that curcumol might be a developmental neurotoxicant and NCAM/FAK signaling pathway may play an important role in curcumol-evoked inhibition of neurite outgrowth.	curcumol	137-145	neural cell adhesion molecule 1	Rattus norvegicus	80-84
27125675-0	2016	Curcumol Suppresses Breast Cancer Cell Metastasis by Inhibiting MMP-9 Via JNK1/2 and Akt-Dependent NF-kappaB Signaling Pathways.	curcumol	0-8	matrix metallopeptidase 9	Homo sapiens	64-69
30641012-14	2016	Curcumol down-regulated the expression of osteogenic differentiation related gene RANKL, and up-regulated the expression of OPG.	curcumol	0-8	TNF superfamily member 11	Homo sapiens	82-87
30641012-14	2016	Curcumol down-regulated the expression of osteogenic differentiation related gene RANKL, and up-regulated the expression of OPG.	curcumol	0-8	TNF receptor superfamily member 11b	Homo sapiens	124-127
30641012-16	2016	Curcumol up-regulated the expression of OPG as well as down-regulated the expression of RANKL.	curcumol	0-8	TNF receptor superfamily member 11b	Homo sapiens	40-43
30641012-16	2016	Curcumol up-regulated the expression of OPG as well as down-regulated the expression of RANKL.	curcumol	0-8	TNF superfamily member 11	Homo sapiens	88-93
27125675-8	2016	Moreover, curcumol inhibited the activation of c-Jun N-terminal kinase (JNK) 1/2 and Akt (Ser473).	curcumol	10-18	AKT serine/threonine kinase 1	Homo sapiens	85-88
27125675-10	2016	Furthermore, JNK inhibitor SP600125 and Akt (Ser473) inhibitor LY294002 enhanced the inhibition of curcumol on NF-kappaB p65 nuclear translocation.	curcumol	99-107	mitogen-activated protein kinase 8	Homo sapiens	13-16
27125675-10	2016	Furthermore, JNK inhibitor SP600125 and Akt (Ser473) inhibitor LY294002 enhanced the inhibition of curcumol on NF-kappaB p65 nuclear translocation.	curcumol	99-107	AKT serine/threonine kinase 1	Homo sapiens	40-43
27125675-10	2016	Furthermore, JNK inhibitor SP600125 and Akt (Ser473) inhibitor LY294002 enhanced the inhibition of curcumol on NF-kappaB p65 nuclear translocation.	curcumol	99-107	nuclear factor kappa B subunit 1	Homo sapiens	111-120
27125675-11	2016	Finally, supplementation with SP600125, LY294002, or NF-kappaB inhibitor Ammonium pyrrolidinedithiocarbamate (PDTC) significantly enhanced the inhibitory effect of curcumol on MMP-9 expression and cell migration, invasion, and adhesion in MDA-MB-231 cells.	curcumol	164-172	nuclear factor kappa B subunit 1	Homo sapiens	53-62
27125675-11	2016	Finally, supplementation with SP600125, LY294002, or NF-kappaB inhibitor Ammonium pyrrolidinedithiocarbamate (PDTC) significantly enhanced the inhibitory effect of curcumol on MMP-9 expression and cell migration, invasion, and adhesion in MDA-MB-231 cells.	curcumol	164-172	matrix metallopeptidase 9	Homo sapiens	176-181
27125675-12	2016	Our findings provide evidence for the suppression of breast cancer cell metastasis by curcumol and suggest that the inhibition of MMP-9 via JNK1/2 and Akt (Ser473)-dependent NF-kappaB signaling pathways may be the underlying mechanisms.	curcumol	86-94	matrix metallopeptidase 9	Homo sapiens	130-135
27125675-0	2016	Curcumol Suppresses Breast Cancer Cell Metastasis by Inhibiting MMP-9 Via JNK1/2 and Akt-Dependent NF-kappaB Signaling Pathways.	curcumol	0-8	mitogen-activated protein kinase 8	Homo sapiens	74-80
27125675-0	2016	Curcumol Suppresses Breast Cancer Cell Metastasis by Inhibiting MMP-9 Via JNK1/2 and Akt-Dependent NF-kappaB Signaling Pathways.	curcumol	0-8	AKT serine/threonine kinase 1	Homo sapiens	85-88
27125675-0	2016	Curcumol Suppresses Breast Cancer Cell Metastasis by Inhibiting MMP-9 Via JNK1/2 and Akt-Dependent NF-kappaB Signaling Pathways.	curcumol	0-8	nuclear factor kappa B subunit 1	Homo sapiens	99-108
27125675-7	2016	Further investigations revealed that curcumol decreased the enzyme activity and protein expression of matrix metalloproteinase (MMP-9) in MDA-MB-231 cells.	curcumol	37-45	matrix metallopeptidase 9	Homo sapiens	128-133
27125675-8	2016	Moreover, curcumol inhibited the activation of c-Jun N-terminal kinase (JNK) 1/2 and Akt (Ser473).	curcumol	10-18	mitogen-activated protein kinase 9	Homo sapiens	47-80
25824755-0	2015	Curcumol induces apoptosis in SPC-A-1 human lung adenocarcinoma cells and displays anti-neoplastic effects in tumor bearing mice.	curcumol	0-8	proline rich protein gene cluster	Homo sapiens	30-33
26307972-0	2015	Curcumol Inhibits Growth and Induces Apoptosis of Colorectal Cancer LoVo Cell Line via IGF-1R and p38 MAPK Pathway.	curcumol	0-8	insulin like growth factor 1 receptor	Homo sapiens	87-93
26307972-0	2015	Curcumol Inhibits Growth and Induces Apoptosis of Colorectal Cancer LoVo Cell Line via IGF-1R and p38 MAPK Pathway.	curcumol	0-8	mitogen-activated protein kinase 14	Homo sapiens	98-101
26307972-6	2015	Immunohistochemical and Western blot analysis revealed that curcumol could decrease the expression of ki-67, Bcl-2 as well as CREB1, and increase the expression of Bax and the phosphorylation of p38, which were consistent with our in vitro study.	curcumol	60-68	BCL2 apoptosis regulator	Homo sapiens	109-114
26307972-6	2015	Immunohistochemical and Western blot analysis revealed that curcumol could decrease the expression of ki-67, Bcl-2 as well as CREB1, and increase the expression of Bax and the phosphorylation of p38, which were consistent with our in vitro study.	curcumol	60-68	cAMP responsive element binding protein 1	Homo sapiens	126-131
26307972-6	2015	Immunohistochemical and Western blot analysis revealed that curcumol could decrease the expression of ki-67, Bcl-2 as well as CREB1, and increase the expression of Bax and the phosphorylation of p38, which were consistent with our in vitro study.	curcumol	60-68	BCL2 associated X, apoptosis regulator	Homo sapiens	164-167
26307972-6	2015	Immunohistochemical and Western blot analysis revealed that curcumol could decrease the expression of ki-67, Bcl-2 as well as CREB1, and increase the expression of Bax and the phosphorylation of p38, which were consistent with our in vitro study.	curcumol	60-68	mitogen-activated protein kinase 14	Homo sapiens	195-198
26307972-7	2015	Overall, our in vitro and in vivo data confirmed the anti-cancer activity of curcumol, which was related to a significant inhibition of IGF-1R and activation of p38 MAPKs, indicating that curcumol may be a potential anti-tumor agent for colorectal carcinoma therapy.	curcumol	77-85	insulin like growth factor 1 receptor	Homo sapiens	136-142
26307972-7	2015	Overall, our in vitro and in vivo data confirmed the anti-cancer activity of curcumol, which was related to a significant inhibition of IGF-1R and activation of p38 MAPKs, indicating that curcumol may be a potential anti-tumor agent for colorectal carcinoma therapy.	curcumol	77-85	mitogen-activated protein kinase 14	Homo sapiens	161-164
26307972-7	2015	Overall, our in vitro and in vivo data confirmed the anti-cancer activity of curcumol, which was related to a significant inhibition of IGF-1R and activation of p38 MAPKs, indicating that curcumol may be a potential anti-tumor agent for colorectal carcinoma therapy.	curcumol	188-196	insulin like growth factor 1 receptor	Homo sapiens	136-142
26307972-7	2015	Overall, our in vitro and in vivo data confirmed the anti-cancer activity of curcumol, which was related to a significant inhibition of IGF-1R and activation of p38 MAPKs, indicating that curcumol may be a potential anti-tumor agent for colorectal carcinoma therapy.	curcumol	188-196	mitogen-activated protein kinase 14	Homo sapiens	161-164
25824755-4	2015	It was found that curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses.	curcumol	18-26	proline rich protein gene cluster	Homo sapiens	101-104
25869249-8	2015	The results indicated that apigenin (Api), curcumol (Cur) and praeruptorin A (Pra A) were identified as potent activators of hPXR, and Pra A was also a ligand of <protein-id="761">hCAR.	curcumol	43-51	nuclear receptor subfamily 1 group I member 2	Homo sapiens	125-129
24855828-8	2014	Isoalantolactone and schisandrin A are potent inhibitors of CYP2C19, while curcumol is a moderate potent inhibitor of CYP2C19.	curcumol	75-83	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	118-125
25220584-0	2014	Curcumol induces HSC-T6 cell death through suppression of Bcl-2: involvement of PI3K and NF-kappaB pathways.	curcumol	0-8	BCL2, apoptosis regulator	Rattus norvegicus	58-63
25220584-4	2014	The aim of this study is to test the hypothesis that the interruption of the phosphatidylinositol 3 kinase (PI3K)/nuclear factor-kappaB (NF-kappaB) signaling pathway by curcumol might induce apoptosis of activated HSCs.	curcumol	169-177	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	77-106
25220584-5	2014	Our results indicated that curcumol-induced growth inhibition correlated with apoptosis induction as evidenced by Annexin V staining, and cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in HSC-T6.	curcumol	27-35	annexin A5	Rattus norvegicus	114-123
25220584-5	2014	Our results indicated that curcumol-induced growth inhibition correlated with apoptosis induction as evidenced by Annexin V staining, and cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in HSC-T6.	curcumol	27-35	caspase 3	Rattus norvegicus	150-192
25220584-7	2014	Suppression of the NF-kappaB translocation via inhibition of IkappaB-alpha phosphorylation by the curcumol led to the inhibition of expression of NF-kappaB-regulated gene, e.g. Bcl-xL and Bcl-2, in a PI3K-dependent manner, which is upstream of NF-kappaB activation.	curcumol	98-106	NFKB inhibitor alpha	Rattus norvegicus	61-74
25220584-7	2014	Suppression of the NF-kappaB translocation via inhibition of IkappaB-alpha phosphorylation by the curcumol led to the inhibition of expression of NF-kappaB-regulated gene, e.g. Bcl-xL and Bcl-2, in a PI3K-dependent manner, which is upstream of NF-kappaB activation.	curcumol	98-106	Bcl2-like 1	Rattus norvegicus	177-183
25220584-7	2014	Suppression of the NF-kappaB translocation via inhibition of IkappaB-alpha phosphorylation by the curcumol led to the inhibition of expression of NF-kappaB-regulated gene, e.g. Bcl-xL and Bcl-2, in a PI3K-dependent manner, which is upstream of NF-kappaB activation.	curcumol	98-106	BCL2, apoptosis regulator	Rattus norvegicus	188-193
24877754-0	2014	The molecular mechanism of curcumol on inducing cell growth arrest and apoptosis in Jurkat cells, a model of CD4+ T cells.	curcumol	27-35	CD4 molecule	Homo sapiens	109-112
24877754-9	2014	The study results showed that curcumol could inhibit the IL-2-induced Jurkat cell proliferation in a concentration- and time-dependent manner in vitro.	curcumol	30-38	interleukin 2	Homo sapiens	57-61
24877754-10	2014	Curcumol could cause cell cycle arrest at the S phase, induce cell apoptosis, and inhibit the expression of Bcl-2 in a dose-dependent manner.	curcumol	0-8	BCL2 apoptosis regulator	Homo sapiens	108-113
24877754-11	2014	Curcumol at 50mug/mL and Jak3 inhibitor ZM39923 could inhibit the phosphorylation of Jak3 and STAT5a.	curcumol	0-8	Janus kinase 3	Homo sapiens	85-89
24877754-11	2014	Curcumol at 50mug/mL and Jak3 inhibitor ZM39923 could inhibit the phosphorylation of Jak3 and STAT5a.	curcumol	0-8	signal transducer and activator of transcription 5A	Homo sapiens	94-100
24877754-12	2014	In conclusion, the underlying mechanism of curcumol on suppressing CD4(+) T cell proliferation and inducing apoptosis might partly be mediated by inhibition of Jak3-STAT5-related molecular activities and Bcl-2 expression, respectively; further studies are required in vivo to test the use of curcumol as a promising therapeutic option for RA.	curcumol	43-51	CD4 molecule	Homo sapiens	67-70
24877754-12	2014	In conclusion, the underlying mechanism of curcumol on suppressing CD4(+) T cell proliferation and inducing apoptosis might partly be mediated by inhibition of Jak3-STAT5-related molecular activities and Bcl-2 expression, respectively; further studies are required in vivo to test the use of curcumol as a promising therapeutic option for RA.	curcumol	43-51	Janus kinase 3	Homo sapiens	160-164
24877754-12	2014	In conclusion, the underlying mechanism of curcumol on suppressing CD4(+) T cell proliferation and inducing apoptosis might partly be mediated by inhibition of Jak3-STAT5-related molecular activities and Bcl-2 expression, respectively; further studies are required in vivo to test the use of curcumol as a promising therapeutic option for RA.	curcumol	43-51	signal transducer and activator of transcription 5A	Homo sapiens	165-170
24877754-12	2014	In conclusion, the underlying mechanism of curcumol on suppressing CD4(+) T cell proliferation and inducing apoptosis might partly be mediated by inhibition of Jak3-STAT5-related molecular activities and Bcl-2 expression, respectively; further studies are required in vivo to test the use of curcumol as a promising therapeutic option for RA.	curcumol	43-51	BCL2 apoptosis regulator	Homo sapiens	204-209
24732351-0	2014	Curcumol suppresses RANKL-induced osteoclast formation by attenuating the JNK signaling pathway.	curcumol	0-8	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	20-25
24732351-2	2014	In the present study, we demonstrate that curcumol, one of the major components of the essential oil of Rhizoma Curcumae, exhibits an inhibitory effect on receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclast differentiation with both bone marrow-derived macrophages and RAW264.7 cells in a dose-dependent manner.	curcumol	42-50	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	155-205
24732351-2	2014	In the present study, we demonstrate that curcumol, one of the major components of the essential oil of Rhizoma Curcumae, exhibits an inhibitory effect on receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclast differentiation with both bone marrow-derived macrophages and RAW264.7 cells in a dose-dependent manner.	curcumol	42-50	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	207-212
24732351-3	2014	In addition, RANKL-induced mRNA expression of osteoclast-specific genes, such as tartrate-resistant acid phosphatase, calcitonin receptor, and cathepsin K, is prominently reduced in the presence of curcumol.	curcumol	198-206	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	13-18
24732351-3	2014	In addition, RANKL-induced mRNA expression of osteoclast-specific genes, such as tartrate-resistant acid phosphatase, calcitonin receptor, and cathepsin K, is prominently reduced in the presence of curcumol.	curcumol	198-206	calcitonin receptor	Mus musculus	118-137
24732351-3	2014	In addition, RANKL-induced mRNA expression of osteoclast-specific genes, such as tartrate-resistant acid phosphatase, calcitonin receptor, and cathepsin K, is prominently reduced in the presence of curcumol.	curcumol	198-206	cathepsin K	Mus musculus	143-154
24732351-4	2014	Furthermore, the molecular mechanism of action was investigated, and curcumol inhibited osteoclastogenesis by specifically impairing RANKL-induced c-Jun N-terminal kinase (JNK)/activator protein-1 (AP-1) signaling, which was further identified in rescue studies by means of anisomycin, a JNK signaling-specific activator.	curcumol	69-77	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	133-138
24732351-4	2014	Furthermore, the molecular mechanism of action was investigated, and curcumol inhibited osteoclastogenesis by specifically impairing RANKL-induced c-Jun N-terminal kinase (JNK)/activator protein-1 (AP-1) signaling, which was further identified in rescue studies by means of anisomycin, a JNK signaling-specific activator.	curcumol	69-77	jun proto-oncogene	Mus musculus	198-202
24732351-5	2014	Taken together, these findings suggest that curcumol suppresses RANKL-induced osteoclast differentiation through the JNK/AP-1 signaling pathway, and may be useful as a therapeutic treatment for bone resorption-associated diseases.	curcumol	44-52	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	64-69
24732351-5	2014	Taken together, these findings suggest that curcumol suppresses RANKL-induced osteoclast differentiation through the JNK/AP-1 signaling pathway, and may be useful as a therapeutic treatment for bone resorption-associated diseases.	curcumol	44-52	jun proto-oncogene	Mus musculus	121-125
24269960-0	2014	Curcumol exhibits anti-inflammatory properties by interfering with the JNK-mediated AP-1 pathway in lipopolysaccharide-activated RAW264.7 cells.	curcumol	0-8	mitogen-activated protein kinase 8	Mus musculus	71-74
24269960-5	2014	Moreover, curcumol inhibits LPS-induced production of TNF-alpha, IL-1beta and IL-6 at both the transcriptional and translational levels.	curcumol	10-18	tumor necrosis factor	Mus musculus	54-63
24269960-4	2014	We show that curcumol inhibits LPS-induced NO production by suppressing iNOS mRNA expression and protein level but not iNOS activity.	curcumol	13-21	nitric oxide synthase 2, inducible	Mus musculus	72-76
24269960-5	2014	Moreover, curcumol inhibits LPS-induced production of TNF-alpha, IL-1beta and IL-6 at both the transcriptional and translational levels.	curcumol	10-18	interleukin 1 beta	Mus musculus	65-73
24269960-5	2014	Moreover, curcumol inhibits LPS-induced production of TNF-alpha, IL-1beta and IL-6 at both the transcriptional and translational levels.	curcumol	10-18	interleukin 6	Mus musculus	78-82
22474524-3	2012	To explore the anti-cell proliferation mechanism of curcumol, a pure monomer extracted from Chinese medical plant zedoary rhizome, the changes of Jak2-STAT1/3 signal pathway-related molecules in synoviocytes were observed in vitro.	curcumol	52-60	signal transducer and activator of transcription 1	Homo sapiens	151-156
22474524-9	2012	Furthermore, the different concentration curcumol could downregulate the DNA binding activities of STAT1 and STAT3 (P &lt; 0.05) and inhibit the phosphorylation of Jak2 while it had no effect on the protein expressions of STAT1 and STAT3.	curcumol	41-49	signal transducer and activator of transcription 1	Homo sapiens	99-104
22474524-9	2012	Furthermore, the different concentration curcumol could downregulate the DNA binding activities of STAT1 and STAT3 (P &lt; 0.05) and inhibit the phosphorylation of Jak2 while it had no effect on the protein expressions of STAT1 and STAT3.	curcumol	41-49	signal transducer and activator of transcription 3	Homo sapiens	109-114
22474524-9	2012	Furthermore, the different concentration curcumol could downregulate the DNA binding activities of STAT1 and STAT3 (P &lt; 0.05) and inhibit the phosphorylation of Jak2 while it had no effect on the protein expressions of STAT1 and STAT3.	curcumol	41-49	Janus kinase 2	Homo sapiens	164-168
22474524-9	2012	Furthermore, the different concentration curcumol could downregulate the DNA binding activities of STAT1 and STAT3 (P &lt; 0.05) and inhibit the phosphorylation of Jak2 while it had no effect on the protein expressions of STAT1 and STAT3.	curcumol	41-49	signal transducer and activator of transcription 1	Homo sapiens	222-227
22474524-9	2012	Furthermore, the different concentration curcumol could downregulate the DNA binding activities of STAT1 and STAT3 (P &lt; 0.05) and inhibit the phosphorylation of Jak2 while it had no effect on the protein expressions of STAT1 and STAT3.	curcumol	41-49	signal transducer and activator of transcription 3	Homo sapiens	232-237
22474524-11	2012	In conclusion, curcumol might suppress the FLS proliferation and DNA synthesis induced by PDGF-BB through attenuating Jak2 phosphorylation, downregulating STAT1 and STAT3 DNA-binding activities, which could provide theoretical foundation for clinical treatment of RA.	curcumol	15-23	Janus kinase 2	Homo sapiens	118-122
22474524-11	2012	In conclusion, curcumol might suppress the FLS proliferation and DNA synthesis induced by PDGF-BB through attenuating Jak2 phosphorylation, downregulating STAT1 and STAT3 DNA-binding activities, which could provide theoretical foundation for clinical treatment of RA.	curcumol	15-23	signal transducer and activator of transcription 1	Homo sapiens	155-160
22474524-11	2012	In conclusion, curcumol might suppress the FLS proliferation and DNA synthesis induced by PDGF-BB through attenuating Jak2 phosphorylation, downregulating STAT1 and STAT3 DNA-binding activities, which could provide theoretical foundation for clinical treatment of RA.	curcumol	15-23	signal transducer and activator of transcription 3	Homo sapiens	165-170
24010301-9	2013	CONCLUSION: Curcumol can inhibit the proliferation of HepG2 cells in vitro and induce G1 arrest of cell cycle through mechanisms activating p53 and pRB pathways that involve genes of cyclin A1, CDK2, CDK8, p21WAF1 and p27KIP1.	curcumol	12-20	tumor protein p53	Homo sapiens	140-143
24010301-9	2013	CONCLUSION: Curcumol can inhibit the proliferation of HepG2 cells in vitro and induce G1 arrest of cell cycle through mechanisms activating p53 and pRB pathways that involve genes of cyclin A1, CDK2, CDK8, p21WAF1 and p27KIP1.	curcumol	12-20	RB transcriptional corepressor 1	Homo sapiens	148-151
24010301-9	2013	CONCLUSION: Curcumol can inhibit the proliferation of HepG2 cells in vitro and induce G1 arrest of cell cycle through mechanisms activating p53 and pRB pathways that involve genes of cyclin A1, CDK2, CDK8, p21WAF1 and p27KIP1.	curcumol	12-20	cyclin A1	Homo sapiens	183-192
24010301-9	2013	CONCLUSION: Curcumol can inhibit the proliferation of HepG2 cells in vitro and induce G1 arrest of cell cycle through mechanisms activating p53 and pRB pathways that involve genes of cyclin A1, CDK2, CDK8, p21WAF1 and p27KIP1.	curcumol	12-20	cyclin dependent kinase 2	Homo sapiens	194-198
24010301-9	2013	CONCLUSION: Curcumol can inhibit the proliferation of HepG2 cells in vitro and induce G1 arrest of cell cycle through mechanisms activating p53 and pRB pathways that involve genes of cyclin A1, CDK2, CDK8, p21WAF1 and p27KIP1.	curcumol	12-20	cyclin dependent kinase 8	Homo sapiens	200-204
24010301-9	2013	CONCLUSION: Curcumol can inhibit the proliferation of HepG2 cells in vitro and induce G1 arrest of cell cycle through mechanisms activating p53 and pRB pathways that involve genes of cyclin A1, CDK2, CDK8, p21WAF1 and p27KIP1.	curcumol	12-20	cyclin dependent kinase inhibitor 1B	Homo sapiens	218-225
22474524-0	2012	Inhibitory Effect of Curcumol on Jak2-STAT Signal Pathway Molecules of Fibroblast-Like Synoviocytes in Patients with Rheumatoid Arthritis.	curcumol	21-29	Janus kinase 2	Homo sapiens	33-37
22474524-3	2012	To explore the anti-cell proliferation mechanism of curcumol, a pure monomer extracted from Chinese medical plant zedoary rhizome, the changes of Jak2-STAT1/3 signal pathway-related molecules in synoviocytes were observed in vitro.	curcumol	52-60	Janus kinase 2	Homo sapiens	146-150
21722536-1	2011	AIM: To investigate the effect of curcumol on the proliferation, apoptosis and the expression NF-kappaB in nasopharyngeal carcinoma cell line CNE-2.	curcumol	34-42	nuclear factor kappa B subunit 1	Homo sapiens	94-103
21722536-2	2011	METHODS: CNE-2 cells were treated with curcumol at different concentration(12.5, 25, 50, 100 mg/L) and the control group; the effect of proliferation was detected by MTT method; the apoptosis was analyzed by hoechst 33342 flourescence staning and flow cytometry; the expression of NF-kappaB was detected with western blotting.	curcumol	39-47	nuclear factor kappa B subunit 1	Homo sapiens	281-290
21722536-4	2011	CONCLUSION: Curcumol is capable of significantly inhibiting proliferation and inducing apoptosis of CNE-2" cells in vitro, the mechanism of curcumol anti-tumor may be related to the down regulated of the NF-kappaB protein level.	curcumol	12-20	nuclear factor kappa B subunit 1	Homo sapiens	204-213
21722536-4	2011	CONCLUSION: Curcumol is capable of significantly inhibiting proliferation and inducing apoptosis of CNE-2" cells in vitro, the mechanism of curcumol anti-tumor may be related to the down regulated of the NF-kappaB protein level.	curcumol	140-148	nuclear factor kappa B subunit 1	Homo sapiens	204-213