PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
6321999-4	1984	The defective locus of one LDL receptor-negative CHO mutant (clone 7a-1) is apparently the structural gene for the LDL receptor (D. Kingsley, M. Segal and M.K., unpublished data).	cho	49-52	low density lipoprotein receptor	Homo sapiens	27-39
6321999-4	1984	The defective locus of one LDL receptor-negative CHO mutant (clone 7a-1) is apparently the structural gene for the LDL receptor (D. Kingsley, M. Segal and M.K., unpublished data).	cho	49-52	low density lipoprotein receptor	Homo sapiens	115-127
6139093-3	1983	Permanently repressed levels of both HMG CoA synthase and HMG CoA reductase activities are observed in another CHO mutant, phenotypically a mevalonate auxotroph.	cho	111-114	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Cricetulus griseus	58-75
6139093-5	1983	Incubation of CHO cells with sublethal concentrations of mevinolin produces an inhibition of the conversion of [14C]acetate to cholesterol and results in elevated levels of both HMG CoA synthase and HMG CoA reductase activities.	cho	14-17	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Cricetulus griseus	199-216
6865996-4	1983	The relationship between O6-methylguanine and induced mutations in CHO cells is similar to that previously reported in CHO cells for O6-ethylguanine and mutations (Heflich et al., 1982) and indicates that alkylation-induced mutations at the HGPRT locus in CHO cells are primarily associated with O6-alkylguanine formation.	cho	67-70	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	241-246
6308636-4	1983	CHO-produced Hu IFN-gamma migrates as two bands corresponding to molecular weights of 25,000 and 21,000 on NaDodSO4/polyacrylamide gels.	cho	0-3	interferon gamma	Homo sapiens	16-25
6807556-7	1982	Furthermore, the time-course for killing CHO cells deficient in HGPRTase was different from that in wild-type cells containing the enzyme.	cho	41-44	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	64-72
6835209-5	1983	Hybridization complementation tests revealed that the two-step CHO cell emetine resistance mutants were members of the same complementation group defined by one-step CHO cell mutants, EmtB.	cho	63-66	40S ribosomal protein S14	Cricetulus griseus	184-188
14582155-5	1982	The binding of [125I]ricin to AR10, AR100-6, AR100-9, and AR100-13 cells was decreased to about 30% of that of CHO.	cho	111-114	ricin	Ricinus communis	21-26
6286144-2	1982	Similar analyses of CHO cells that were treated with colcemid show the presence of at least two to three additional, more acidic, phosphorylated vimentin isoelectric variants.	cho	20-23	vimentin	Cricetulus griseus	145-153
6286144-5	1982	CHO cells enriched in mitotic cells without antimitotic drugs demonstrate the same alteration in the isoelectric focusing pattern of phosphorylated vimentin.	cho	0-3	vimentin	Cricetulus griseus	148-156
7191425-10	1980	These results suggest that the HeLa and CHO cages include intermediate filaments of the vimentin type.	cho	40-43	vimentin	Homo sapiens	88-96
489015-2	1979	Cycloheximide(CHM)-resistant mutant Chinese hamster ovary (CHO) and human cells were induced with N-nitrosomethylurea (NMU) and ethyl methanesulfonate (EMS); the mutants were viable and showed unlimited growth in the presence of CHM (7 X 10(-7) M), whereas this concentration inhibits protein synthesis in vivo as well as in vitro.	cho	59-62	rab proteins geranylgeranyltransferase component A 1	Cricetulus griseus	14-17
7410492-4	1980	The growth inhibitory effects of alanosine, or alanosine and guanine, on CHO cells are completely reverted by the addition of adenine to the culture medium, and the synergistic effect of guanine is not observed in mutants which lack the enzyme hypoxanthine-guanine phosphoribosyl transferase.	cho	73-76	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	244-291
7360155-13	1980	The rapid expression of mutations for both markers, particularly AAr, combined with the advantage that large inocula can be plated for selection of mutants, make this CHO strain an attractive system for the simultaneous measurement of mutations at the autosomal aprt and X-linked hprt loci.	cho	167-170	adenine phosphoribosyltransferase	Cricetulus griseus	262-266
7360155-13	1980	The rapid expression of mutations for both markers, particularly AAr, combined with the advantage that large inocula can be plated for selection of mutants, make this CHO strain an attractive system for the simultaneous measurement of mutations at the autosomal aprt and X-linked hprt loci.	cho	167-170	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	280-284
397622-6	1979	The specific activity of HPRT in transformant extracts ranged from 0.5 to 5 times the CHO level.	cho	86-89	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	25-29
30837228-0	2019	Simultaneous expression of ClopHensor and SLC26A3 reveals the nature of endogenous oxalate transport in CHO cells.	cho	104-107	chloride anion exchanger	Cricetulus griseus	42-49
287027-6	1979	When CHO cells are grown conventionally on plastic substrata or in suspension, insulin has little effect on cell growth at 4% serum concentration.	cho	5-8	insulin	Cricetulus griseus	79-86
32864736-12	2020	Conversely, CNO-mediated inhibition of the hypothalamic-vagal oxytocinergic neurocircuitry prevented the CHo-induced adaptation in gastric emptying, and increase in gastric tone and motility.	cho	105-108	biogenesis of lysosomal organelles complex 1 subunit 4	Rattus norvegicus	12-15
31116974-4	2019	We show that the loss of Pericardin, a major constituent of the ChO ECM, alters the mechanical properties of the ChO resulting in short-wavelength buckling of the accessory cells upon muscle contraction and low compressive strain within the organ.	cho	64-67	pericardin	Drosophila melanogaster	25-35
31116974-4	2019	We show that the loss of Pericardin, a major constituent of the ChO ECM, alters the mechanical properties of the ChO resulting in short-wavelength buckling of the accessory cells upon muscle contraction and low compressive strain within the organ.	cho	113-116	pericardin	Drosophila melanogaster	25-35
31292678-6	2019	Stable overexpression of miR-106b in CHO cells promoted CHO cell viability and subsequent antibody expression in transient transfection assay.	cho	37-40	microRNA 106b	Cricetulus griseus	25-33
31292678-6	2019	Stable overexpression of miR-106b in CHO cells promoted CHO cell viability and subsequent antibody expression in transient transfection assay.	cho	56-59	microRNA 106b	Cricetulus griseus	25-33
31292678-9	2019	Taken together, our findings highlight the effect of miR-106b inhibition in CYLD synthesis and its function in antibody expression as a new target for improving CHO manufacturing cells.	cho	161-164	microRNA 106b	Cricetulus griseus	53-61
31292678-9	2019	Taken together, our findings highlight the effect of miR-106b inhibition in CYLD synthesis and its function in antibody expression as a new target for improving CHO manufacturing cells.	cho	161-164	ubiquitin carboxyl-terminal hydrolase CYLD	Cricetulus griseus	76-80
31309323-8	2019	IL-6 serum levels were lower at the analysed postoperative time points in the CHO group (p < 0.001).	cho	78-81	interleukin 6	Homo sapiens	0-4
31419796-12	2019	In GBM, the mean T/N ratio in the IDH-wt group was significantly higher than that in the IDH-mut group for both MET (p = 0.034) and CHO (p = 0.01).	cho	132-135	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	34-37
30610443-10	2019	Effect size increase in serum creatine kinase (CK) activity, CK-MB and C-reactive protein concentrations was less in PRO than CHO (Cohen"s d mean +- SD, PRO: 2.91 +- 2.07; CHO: 7.56 +- 4.81, p = 0.046).	cho	126-129	C-reactive protein	Homo sapiens	71-89
30845767-6	2019	G2-beta-CD attenuated dysfunction of intercellular cholesterol trafficking and lysosome volume in Npc1 deficient CHO cells in a concentration dependent manner.	cho	113-116	beta-carotene oxygenase 1	Mus musculus	3-10
30845767-6	2019	G2-beta-CD attenuated dysfunction of intercellular cholesterol trafficking and lysosome volume in Npc1 deficient CHO cells in a concentration dependent manner.	cho	113-116	NPC intracellular cholesterol transporter 1	Cricetulus griseus	98-102
30726723-4	2019	Here, we report that piezo-like (pzl), a homolog for mammalian piezo1 and 2, is essential for Cho"s function in locomotion.	cho	94-97	piezo type mechanosensitive ion channel component 1	Homo sapiens	63-75
28576848-6	2017	The glycan profiles of CHO expressed FcgammaRI and FcgammaRIIIaPhe158/Val158 were compared with the glycan profiles of the receptors expressed in NS0 and HEK293 cells and we show that the glycan type and abundance differs significantly between the receptors and that these glycan differences lead to the observed differences in the respective FcgammaR binding patterns with rituximab.	cho	23-26	Fc receptor, IgG, high affinity I	Mus musculus	37-46
29987891-3	2018	In this study, we have comparatively characterized AAT expression in untransfected and monoclonal antibody (MAb)-producing CHO cells using transcriptome analysis by RNA-seq, and mechanistically dissected AAT function using a variety of transporter-specific chemical inhibitors, comparing their effect on cell proliferation, recombinant protein production, and amino acid transport.	cho	123-126	serpin family A member 1	Homo sapiens	51-54
29689305-7	2018	We also observed glycoforms of the Fab produced from P. pastoris, while Fab secreted from CHO was the most homogeneous despite a much longer culture time and slightly higher estimated cost of goods.	cho	90-93	FA complementation group B	Homo sapiens	72-75
29368032-5	2018	The overall production yield of the antibody anti-PD1 increased approximately 82% in CHO cells co-transfected with Bcl-x L , and 34% in CHO cells co-transfected with Mcl-1.	cho	136-139	induced myeloid leukemia cell differentiation protein Mcl-1	Cricetulus griseus	166-171
30519645-8	2019	It was demonstrated that P38B exerted antitumor activity against the mouse xenograft model using CHO/dPDPN.	cho	97-100	mitogen-activated protein kinase 11	Mus musculus	25-29
29915899-0	2018	Stable expression of infliximab in CRISPR/Cas9-mediated BAK1-deficient CHO cells.	cho	71-74	bcl-2 homologous antagonist/killer	Cricetulus griseus	56-60
29698406-3	2018	Due to the low production of gp120 proteins in CHO cells (2-20 mg/L), cleavage sites in V1V2 loops (A244) and V3 loop (MN) causing heterogeneous antigen products, it was an urgent need to generate CHO cells harboring A244 gp120 with high production yields and an additional, homogenous and uncleaved subtype B gp120 protein to replace MN used in RV144 for the future clinical trials.	cho	47-50	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	29-34
28828541-8	2017	Moreover, uptake in OATP-transfected CHO cells was reduced by OATP inhibitors.	cho	37-40	solute carrier organic anion transporter family member 1A2	Homo sapiens	20-24
28828541-8	2017	Moreover, uptake in OATP-transfected CHO cells was reduced by OATP inhibitors.	cho	37-40	solute carrier organic anion transporter family member 1A2	Homo sapiens	62-66
28165157-8	2017	We hence demonstrate that ATF6beta-based cell line engineering is a promising strategy to improve the productivity of CHO producer cells by activating an optimally balanced UPR program.	cho	118-121	cyclic AMP-dependent transcription factor ATF-6 beta	Cricetulus griseus	26-34
28371547-0	2017	miR-143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult-to-express proteins.	cho	25-28	microRNA 143	Cricetulus griseus	0-7
28371547-0	2017	miR-143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult-to-express proteins.	cho	25-28	mitogen-activated protein kinase 7	Cricetulus griseus	16-21
28371547-8	2017	Both transient and stable overexpression of miR-143 significantly improved protein production without negatively affecting cell growth and viability of different recombinant CHO cells.	cho	174-177	microRNA 143	Cricetulus griseus	44-51
28418635-7	2017	Combined with MTX selection, CRISPRi-mediated repression of dhfr imparted extra selective pressure to force CHO cells to coamplify more copies of dhfr and egfp genes.	cho	108-111	dihydrofolate reductase	Cricetulus griseus	60-64
28418635-7	2017	Combined with MTX selection, CRISPRi-mediated repression of dhfr imparted extra selective pressure to force CHO cells to coamplify more copies of dhfr and egfp genes.	cho	108-111	dihydrofolate reductase	Cricetulus griseus	146-150
28763459-5	2017	In the present work, we over-expressed the yeast cytosolic pyruvate carboxylase (PYC2) enzyme in CHO cells to augment pyruvate flux towards the TCA cycle.	cho	97-100	pyruvate carboxylase, mitochondrial	Cricetulus griseus	59-79
28763459-5	2017	In the present work, we over-expressed the yeast cytosolic pyruvate carboxylase (PYC2) enzyme in CHO cells to augment pyruvate flux towards the TCA cycle.	cho	97-100	pyruvate carboxylase 2	Saccharomyces cerevisiae S288C	81-85
28769797-0	2017	Over-expression of a Codon Optimized Yeast Cytosolic Pyruvate Carboxylase (PYC2) in CHO Cells for an Augmented Lactate Metabolism.	cho	84-87	pyruvate carboxylase 2	Saccharomyces cerevisiae S288C	75-79
28161763-6	2017	Six CHO and HuH-7 cell lines that transiently produced FSD-inducible variant fibrinogen presented the fibrous (3.2-22.7 and 2.1-24.5%, respectively) and large granular (5.4-25.5 and 7.7-23.9%) forms of intracellular inclusion bodies.	cho	4-7	fibrinogen beta chain	Homo sapiens	77-87
28344453-1	2017	The purpose of the study was to examine the effect of high-intensity exercise and carbohydrate supplementation (CHO) on plasma visfatin.	cho	112-115	nicotinamide phosphoribosyltransferase	Homo sapiens	127-135
27943242-0	2017	Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations.	cho	34-37	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	57-75
28088541-0	2017	Secretory pathway optimization of CHO producer cells by co-engineering of the mitosRNA-1978 target genes CerS2 and Tbc1D20.	cho	34-37	ceramide synthase 2	Cricetulus griseus	105-110
28088541-0	2017	Secretory pathway optimization of CHO producer cells by co-engineering of the mitosRNA-1978 target genes CerS2 and Tbc1D20.	cho	34-37	TBC1 domain family member 20	Cricetulus griseus	115-122
27493197-1	2016	The capacity to match carbohydrate (CHO) utilization with availability is impaired in insulin-resistant, obese adults at rest.	cho	36-39	insulin	Homo sapiens	86-93
27877136-8	2016	Conversely, pretreatment of CHO cells with 4-Phenyl butyric acid, the ERs inhibitor reduced the MC-LR-induced apoptotic cell death and cellular autophagy as evidenced by the reduced expression of Beclin1 and LC3II.	cho	28-31	beclin-1	Cricetulus griseus	196-203
26989081-6	2016	Most importantly, when CpD expression was knocked out by CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology, C-terminal lysine cleavage was completely abolished in CpD knockout cells based on mass spectrometry analysis, demonstrating that CpD is the only endogenous carboxypeptidase that cleaves antibody heavy chain C-terminal lysine in CHO cells.	cho	365-368	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	23-26
26989081-6	2016	Most importantly, when CpD expression was knocked out by CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology, C-terminal lysine cleavage was completely abolished in CpD knockout cells based on mass spectrometry analysis, demonstrating that CpD is the only endogenous carboxypeptidase that cleaves antibody heavy chain C-terminal lysine in CHO cells.	cho	365-368	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	191-194
26989081-6	2016	Most importantly, when CpD expression was knocked out by CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology, C-terminal lysine cleavage was completely abolished in CpD knockout cells based on mass spectrometry analysis, demonstrating that CpD is the only endogenous carboxypeptidase that cleaves antibody heavy chain C-terminal lysine in CHO cells.	cho	365-368	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	191-194
26989081-7	2016	Hence, our work showed for the first time that the cleavage of antibody heavy chain C-terminal lysine is solely mediated by the carboxypeptidase D in CHO cells and our finding provides one solution to eliminating C-terminal lysine heterogeneity for therapeutic antibody production by knocking out CpD gene expression.	cho	150-153	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	128-146
26989081-7	2016	Hence, our work showed for the first time that the cleavage of antibody heavy chain C-terminal lysine is solely mediated by the carboxypeptidase D in CHO cells and our finding provides one solution to eliminating C-terminal lysine heterogeneity for therapeutic antibody production by knocking out CpD gene expression.	cho	150-153	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	297-300
27565667-5	2016	Inhibition of N-glycosylation by tunicamycin indicated that N-glycosylation of S2-expressed hFIX had occurred to a similar extent as in the CHO-produced hFIX.	cho	140-143	coagulation factor IX	Homo sapiens	92-96
27565667-5	2016	Inhibition of N-glycosylation by tunicamycin indicated that N-glycosylation of S2-expressed hFIX had occurred to a similar extent as in the CHO-produced hFIX.	cho	140-143	coagulation factor IX	Homo sapiens	153-157
27397543-0	2016	Over-expressed human TREK-1 inhibits CHO cell proliferation via inhibiting PKA and p38 MAPK pathways and subsequently inducing G1 arrest.	cho	37-40	potassium two pore domain channel subfamily K member 2	Homo sapiens	21-27
26661088-0	2016	Adaptation of CHO cells in serum-free conditions for erythropoietin production: Application of EVOP technique for process optimization.	cho	14-17	erythropoietin	Cricetulus griseus	53-67
27547109-9	2016	CONCLUSION: The results obtained in this study indicate successful development of the improved CHO host cells through CERT S132A overexpression.	cho	95-98	ceramide transfer protein	Cricetulus griseus	118-122
27016581-6	2016	The release of OXT onto CHO cells in the DMNX was blunted in rats exposed to 21 days of CIH/H.	cho	24-27	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	15-18
27016581-7	2016	Chronic activation of PVN OXT neurons in vivo, using designer receptors exclusively activated by designer drugs, restored the release of OXT onto CHO cells in the DMNX.	cho	146-149	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	26-29
27016581-7	2016	Chronic activation of PVN OXT neurons in vivo, using designer receptors exclusively activated by designer drugs, restored the release of OXT onto CHO cells in the DMNX.	cho	146-149	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	137-140
27006333-4	2016	In CHO cells glycan-deficient PrP also interacts with glycosaminoglycan (GAG) and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in VEGFR2 activation and enhanced Akt phosphorylation.	cho	3-6	major prion protein	Cricetulus griseus	30-33
26461143-7	2016	Functional validation experiments revealed that introduction of miR-483 mimics led to a significant increase in both rAAV and mAB production in HeLa and CHO cells, respectively.	cho	153-156	microRNA 483	Homo sapiens	64-71
27214792-8	2016	In relation to a previous independent CHO study miR-183 may be the most promising target to enhance qp by stable overexpression.	cho	38-41	microRNA 183	Cricetulus griseus	48-55
27468258-7	2016	RESULTS: There were similar decrements in 1RM squat strength and isokinetic peak torque measures in the BCAA-CHO and CHO groups.	cho	109-112	AT-rich interaction domain 4B	Homo sapiens	104-108
27468258-9	2016	A group*time interaction was observed for monocyte percentages (p = 0.01) whereby BCAA-CHO supplementation attenuated increases in this variable over the duration of the protocol compared to CHO supplementation.	cho	87-90	AT-rich interaction domain 4B	Homo sapiens	82-86
26523469-3	2016	Human IGF-1 variants negatively impacted CHO cell growth via the IGF-1 receptor (IGF-1R).	cho	41-44	insulin like growth factor 1	Homo sapiens	6-11
26523469-3	2016	Human IGF-1 variants negatively impacted CHO cell growth via the IGF-1 receptor (IGF-1R).	cho	41-44	insulin-like growth factor 1 receptor	Cricetulus griseus	65-79
26523469-3	2016	Human IGF-1 variants negatively impacted CHO cell growth via the IGF-1 receptor (IGF-1R).	cho	41-44	insulin-like growth factor 1 receptor	Cricetulus griseus	81-87
27089415-6	2016	RESULTS: In L341A/A342L-CB1-CHO cells, cannabinoid agonists significantly stimulated cAMP accumulation over vehicle; (-)-3-[2-hydroxyl-4-(1,1-dimethylheptyl)phenyl]-4-[3-hydroxyl propyl] cyclohexan-1-ol (CP55940)-stimulated [35S]GTPgammaS binding to Gi1/2/3 was reversed, whereas binding to Gs was not different from CB1R.	cho	28-31	cannabinoid receptor 1 (brain)	Mus musculus	24-27
26471004-6	2016	Our data demonstrate that inactivating Slc35c1 gene represents an alternative approach to generate CHO cells for production of fucose-free antibodies.	cho	99-102	GDP-fucose transporter 1	Cricetulus griseus	39-46
25881267-11	2015	The automated assay showed the expected dose-dependent reduction in binding to CHO cells when blocking with soluble chondroitin sulfate A or anti-CD36 antibody.	cho	79-82	platelet glycoprotein 4	Cricetulus griseus	146-150
26538438-4	2016	A second intracellular compartment was also evident in the multicompartmental kinetics of efflux of the prototypic OC [(3)H]1-methyl-4-phenylpyridinium (MPP) from MATE1-expressing CHO cells.	cho	180-183	solute carrier family 47 member 1	Homo sapiens	163-168
26024551-7	2016	RESULTS: Short-serve accuracy was improved after the ingestion of CHO and C+C compared with PLA (P = .001, eta(p)(2) = .50).	cho	66-69	endothelin receptor type A	Homo sapiens	107-110
26475607-10	2015	CONCLUSIONS: Peptide amidation was increased over endogenous levels by exogenous PAM, and targeting PAM to the endoplasmic reticulum or trans-Golgi network increased peptide amidation compared to endogenous CHO PAM.	cho	207-210	peptidyl-glycine alpha-amidating monooxygenase	Cricetulus griseus	100-103
26475607-10	2015	CONCLUSIONS: Peptide amidation was increased over endogenous levels by exogenous PAM, and targeting PAM to the endoplasmic reticulum or trans-Golgi network increased peptide amidation compared to endogenous CHO PAM.	cho	207-210	peptidyl-glycine alpha-amidating monooxygenase	Cricetulus griseus	100-103
25149286-4	2015	Subcultivation of CHO cells in suspension culture using the commercial serum-free medium EX-CELL 302, which contained an IGF-1 analog, supplemented with LPA resulted in gradually increasing specific growth rate comparable to the serum-containing medium and in almost the same high antibody production regardless of the number of generations.	cho	18-21	insulin-like growth factor I	Cricetulus griseus	121-126
26788249-4	2016	Preincubation of the CHO cells with 0.5 mg/mL of plant extracts showed increased expression level of antioxidant genes (SOD2, CAT, and GPx).	cho	21-24	superoxide dismutase [Mn], mitochondrial	Cricetulus griseus	120-124
25716287-9	2015	In CHO cells lacking NPC1 (A101 cells), SM level was lower in the plasma membrane, while it was higher in late endosomes/lysosomes.	cho	3-6	NPC intracellular cholesterol transporter 1	Cricetulus griseus	21-25
25798458-1	2015	Choline dioctylsulfosuccinate [Cho][AOT] (a surface active ionic liquid) has been found to induce all-alpha to alpha + beta conformational transition in the secondary structure of enzyme cytochrome c (Cyt c) with an enhanced peroxidase activity in its aqueous vesicular phase at pH 7.0.	cho	0-3	cytochrome c, somatic	Homo sapiens	187-199
25798458-1	2015	Choline dioctylsulfosuccinate [Cho][AOT] (a surface active ionic liquid) has been found to induce all-alpha to alpha + beta conformational transition in the secondary structure of enzyme cytochrome c (Cyt c) with an enhanced peroxidase activity in its aqueous vesicular phase at pH 7.0.	cho	0-3	cytochrome c, somatic	Homo sapiens	201-206
25798458-2	2015	[Cho][AOT] interacted with Cyt c distinctly at three critical concentrations (aggregation C1, saturation C2 and vesicular C3) as detected from isothermal titration calorimetric analysis.	cho	1-4	cytochrome c, somatic	Homo sapiens	27-32
25798458-2	2015	[Cho][AOT] interacted with Cyt c distinctly at three critical concentrations (aggregation C1, saturation C2 and vesicular C3) as detected from isothermal titration calorimetric analysis.	cho	1-4	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	90-124
25798458-3	2015	Oxidation of heme iron was observed from the disappearance of the Q band in the UV-vis spectra of Cyt c upon [Cho][AOT] binding above C3.	cho	110-113	cytochrome c, somatic	Homo sapiens	98-103
25798458-5	2015	Loss in both the secondary and tertiary structure has been observed in the post-vesicular regime with the change in Cyt c conformation from all-alpha to alpha + beta which is similar to the conformational changes of Cyt c upon binding with mitochondrial membrane (Biochemistry 1998, 37, 6402-6409), thus citing the potential utility of [Cho][AOT] membranes as an artificial analog for in vitro bio-mimicking.	cho	337-340	cytochrome c, somatic	Homo sapiens	116-121
25798458-5	2015	Loss in both the secondary and tertiary structure has been observed in the post-vesicular regime with the change in Cyt c conformation from all-alpha to alpha + beta which is similar to the conformational changes of Cyt c upon binding with mitochondrial membrane (Biochemistry 1998, 37, 6402-6409), thus citing the potential utility of [Cho][AOT] membranes as an artificial analog for in vitro bio-mimicking.	cho	337-340	cytochrome c, somatic	Homo sapiens	216-221
25798458-8	2015	[Cho][AOT] has been found to enhance the peroxidase activity of Cyt c with maximum activity at C3, observed using 2,2"-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt as the substrate in the presence of hydrogen peroxide.	cho	1-4	cytochrome c, somatic	Homo sapiens	64-69
24018795-9	2014	The combination of expression vector and optimized CHO cell extracts enables the production of approximately 50 microg/mL active firefly luciferase within 4 h. The batch-type cell-free coupled transcription-translation system has the potential to perform post-translational modifications, as shown by the glycosylation of erythropoietin.	cho	51-54	erythropoietin	Cricetulus griseus	322-336
24611935-6	2014	The insulinotropic properties of protein co-ingestion were evident in nearly all patients, with 58 out of 60 patients responding >10% when compared with the insulin response following carbohydrate ingestion only (CHO).	cho	216-219	insulin	Homo sapiens	4-11
25572287-6	2015	We then cultured various cell lines using CHO- or CHO-IDO-conditioned medium.	cho	50-53	indoleamine 2,3-dioxygenase 1	Homo sapiens	54-57
25650413-8	2015	Furthermore, application of voriconazole to CHO cells expressing TRPM3, a closely related channel to TRPM1, showed that voriconazole reversibly blocked pregnenolone sulfate-stimulated TRPM3 currents in transfected cells.	cho	44-47	transient receptor potential cation channel, subfamily M, member 3	Mus musculus	65-70
24604007-6	2014	When VIG-1 was transiently expressed in GAR-3/CHO cells, carbachol-stimulated ERK1/2 activation was substantially reduced.	cho	46-49	HABP4_PAI-RBP1 domain-containing protein	Caenorhabditis elegans	5-10
23648861-7	2013	Human alpha2,3-sialyltransferase (alpha2,3-ST) was introduced into EPO-producing CHO cells in order to compensate for the reduced sialylation during supplementation with NAC.	cho	81-84	erythropoietin	Cricetulus griseus	67-70
23676904-5	2013	Overexpression of CERT S132A increased the specific productivity of t-PA-producing CHO cells up to 35%.	cho	83-86	ceramide transfer protein	Cricetulus griseus	18-22
24338886-6	2013	In summary, the mass spectrometric analyses revealed that rhEPO derived from glycoengineered Pichia has a highly uniform bi-antennary N-linked glycan composition and preserves the orthogonal O-linked glycosylation site present on endogenous human EPO and CHO-derived rhEPO.	cho	255-258	erythropoietin	Homo sapiens	60-63
23636490-8	2013	RESULTS: The labeled peptides retained high binding affinity to CXCR4 and showed much higher uptake in CXCR4-positive CHO cells than in CXCR4-negative cells in vitro.	cho	118-121	C-X-C chemokine receptor type 4	Cricetulus griseus	64-69
23636490-8	2013	RESULTS: The labeled peptides retained high binding affinity to CXCR4 and showed much higher uptake in CXCR4-positive CHO cells than in CXCR4-negative cells in vitro.	cho	118-121	C-X-C chemokine receptor type 4	Cricetulus griseus	103-108
23636490-8	2013	RESULTS: The labeled peptides retained high binding affinity to CXCR4 and showed much higher uptake in CXCR4-positive CHO cells than in CXCR4-negative cells in vitro.	cho	118-121	C-X-C chemokine receptor type 4	Cricetulus griseus	103-108
23596182-10	2013	Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P < 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group.	cho	141-144	insulin	Homo sapiens	0-7
23596182-10	2013	Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P < 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group.	cho	161-164	insulin	Homo sapiens	0-7
23589924-9	2013	Compared with cyclin G1-transfected CHO cells, exogenous cyclin G1 protein expression was low in Ishikawa and HEC-1-B cells, and was undetectable in KLE cells.	cho	36-39	cyclin-G1	Cricetulus griseus	14-23
23634230-6	2013	Furthermore, Mek1/2 inhibitors reduce ABCG1 protein levels in ABCG1 overexpressing CHO cells (CHO-ABCG1) and human embryonic kidney 293 (HEK293) cells treated with LXR agonist.	cho	83-86	dual specificity mitogen-activated protein kinase kinase 1	Cricetulus griseus	13-19
23634230-6	2013	Furthermore, Mek1/2 inhibitors reduce ABCG1 protein levels in ABCG1 overexpressing CHO cells (CHO-ABCG1) and human embryonic kidney 293 (HEK293) cells treated with LXR agonist.	cho	83-86	ATP-binding cassette sub-family G member 1	Cricetulus griseus	38-43
23634230-6	2013	Furthermore, Mek1/2 inhibitors reduce ABCG1 protein levels in ABCG1 overexpressing CHO cells (CHO-ABCG1) and human embryonic kidney 293 (HEK293) cells treated with LXR agonist.	cho	83-86	ATP-binding cassette sub-family G member 1	Cricetulus griseus	62-67
22992838-6	2012	In the morphine-treated CHO cells, the hMOR-1 mRNA levels remained the same as the untreated control.	cho	24-27	opioid receptor mu 1	Homo sapiens	39-45
23090292-1	2013	The aim of this study was to observe the intracellular heat shock protein 72 (HSP72) and heme oxygenase-1 (HSP32) response to prolonged interval cycling following the ingestion of carbohydrates (CHO) and sodium bicarbonate (NaHCO(3)).	cho	195-198	heat shock protein family A (Hsp70) member 1A	Homo sapiens	55-76
23090292-1	2013	The aim of this study was to observe the intracellular heat shock protein 72 (HSP72) and heme oxygenase-1 (HSP32) response to prolonged interval cycling following the ingestion of carbohydrates (CHO) and sodium bicarbonate (NaHCO(3)).	cho	195-198	heme oxygenase 1	Homo sapiens	89-105
23090292-1	2013	The aim of this study was to observe the intracellular heat shock protein 72 (HSP72) and heme oxygenase-1 (HSP32) response to prolonged interval cycling following the ingestion of carbohydrates (CHO) and sodium bicarbonate (NaHCO(3)).	cho	195-198	heme oxygenase 1	Homo sapiens	107-112
23607698-7	2013	RESULTS: ATP7B truncations all showed a diffuse and homogenous distribution pattern within the cytosol of CHO and SH-SY5Y cells, whereas its wild-type proteins and T935M mutation were clustered in the Golgi apparatus.	cho	106-109	copper-transporting ATPase 2	Cricetulus griseus	9-14
22968712-2	2013	A competitive binding assay using CHO membranes showed that GM (IC(50) = 0.034 muM) more strongly inhibited the binding of the radioligand [(3)H] LSD to 5-HT(7) receptor than the other alkaloids, suggesting that GM is bound to 5-HT(7) receptor.	cho	34-37	latexin	Homo sapiens	79-82
22783407-5	2012	Reults of the MTT assay revealed that the growth rate of CHO(PDGFRA(L839P)) cells decreased to approximately 60% when exposed to 1 muM imatinib and to approximately 50% with 5 muM imatinib.	cho	57-60	platelet-derived growth factor receptor alpha	Cricetulus griseus	61-67
22919056-3	2012	Ligand selectivity studies indicated that elephant shark MC2R-transfected CHO cells produced cAMP in a dose-dependent manner when stimulated with either human ACTH (1-24) or [Nle(4), d-Phe(7)]-MSH.	cho	74-77	proopiomelanocortin	Homo sapiens	159-163
22919056-3	2012	Ligand selectivity studies indicated that elephant shark MC2R-transfected CHO cells produced cAMP in a dose-dependent manner when stimulated with either human ACTH (1-24) or [Nle(4), d-Phe(7)]-MSH.	cho	74-77	proopiomelanocortin	Homo sapiens	193-196
22492235-3	2012	Here we report a novel Chinese hamster ovary (CHO) mutant, CHO-gmt5, generated by the zinc-finger nuclease technology, in which the Slc35c1 gene was knocked out from a previously reported CHO mutant that has a dysfunctional CMP-sialic acid transporter (CST) gene (Slc35a1).	cho	46-49	GDP-fucose transporter 1	Cricetulus griseus	132-139
22492235-3	2012	Here we report a novel Chinese hamster ovary (CHO) mutant, CHO-gmt5, generated by the zinc-finger nuclease technology, in which the Slc35c1 gene was knocked out from a previously reported CHO mutant that has a dysfunctional CMP-sialic acid transporter (CST) gene (Slc35a1).	cho	46-49	CMP-sialic acid transporter	Cricetulus griseus	224-251
22492235-3	2012	Here we report a novel Chinese hamster ovary (CHO) mutant, CHO-gmt5, generated by the zinc-finger nuclease technology, in which the Slc35c1 gene was knocked out from a previously reported CHO mutant that has a dysfunctional CMP-sialic acid transporter (CST) gene (Slc35a1).	cho	46-49	CMP-sialic acid transporter	Cricetulus griseus	253-256
22492235-3	2012	Here we report a novel Chinese hamster ovary (CHO) mutant, CHO-gmt5, generated by the zinc-finger nuclease technology, in which the Slc35c1 gene was knocked out from a previously reported CHO mutant that has a dysfunctional CMP-sialic acid transporter (CST) gene (Slc35a1).	cho	46-49	CMP-sialic acid transporter	Cricetulus griseus	264-271
22492235-4	2012	Consequently, CHO-gmt5 harbors double genetic defects in Slc35a1 and Slc35c1 and produces N-glycans deficient in both sialic acid and fucose.	cho	14-17	CMP-sialic acid transporter	Cricetulus griseus	57-64
22492235-4	2012	Consequently, CHO-gmt5 harbors double genetic defects in Slc35a1 and Slc35c1 and produces N-glycans deficient in both sialic acid and fucose.	cho	14-17	GDP-fucose transporter 1	Cricetulus griseus	69-76
22230329-5	2012	In comparison to the CHO-derived scFv, the E. coli-derived scFv was found trapped in a misfolded, but monomeric state that was stable for months at 4  C. The misfolded state bound antigen in a heterogeneous fashion that included non-specific binding, which made functional characterization challenging.	cho	21-24	immunglobulin heavy chain variable region	Homo sapiens	33-37
22230329-5	2012	In comparison to the CHO-derived scFv, the E. coli-derived scFv was found trapped in a misfolded, but monomeric state that was stable for months at 4  C. The misfolded state bound antigen in a heterogeneous fashion that included non-specific binding, which made functional characterization challenging.	cho	21-24	immunglobulin heavy chain variable region	Homo sapiens	59-63
22492235-8	2012	We also showed that the conserved glycine residues at positions 180 and 277 of SLC35C1 have significant impacts on AAL binding to CHO-gmt5 cells, suggesting that these conserved glycine residues are required for the transport activity of Slc35 proteins.	cho	130-133	GDP-fucose transporter 1	Cricetulus griseus	79-86
22783407-9	2012	Although the treatment of CHO(PDGFRA(D842V)) and CHO(PDGFRA(Wild)) cells with 5 muM imatinib resulted in a slight increase in the number of apoptotic cells, the percentage of apoptotic cells remained approximately 10% of the total population.	cho	26-29	platelet-derived growth factor receptor alpha	Cricetulus griseus	30-36
22783407-9	2012	Although the treatment of CHO(PDGFRA(D842V)) and CHO(PDGFRA(Wild)) cells with 5 muM imatinib resulted in a slight increase in the number of apoptotic cells, the percentage of apoptotic cells remained approximately 10% of the total population.	cho	49-52	platelet-derived growth factor receptor alpha	Cricetulus griseus	53-59
22068567-4	2012	Currently, there are two main CHO expression systems, dihydrofolate reductase (DHFR)-based methotrexate (MTX) selection and glutamine synthetase (GS)-based methionine sulfoximine (MSX) selection, that have been in wide industrial use.	cho	30-33	dihydrofolate reductase	Cricetulus griseus	54-77
21293890-5	2012	Significant increases in [free IGF-I] and [leucine] were observed in the EAA/CHO group only.	cho	77-80	insulin like growth factor 1	Homo sapiens	31-36
22068567-4	2012	Currently, there are two main CHO expression systems, dihydrofolate reductase (DHFR)-based methotrexate (MTX) selection and glutamine synthetase (GS)-based methionine sulfoximine (MSX) selection, that have been in wide industrial use.	cho	30-33	dihydrofolate reductase	Cricetulus griseus	79-83
22123309-9	2012	DDD.Cg-A(y) showed a low CHO level, although it had Apoa2(b), which was a CHO-increasing allele at the Apoa2 locus.	cho	74-77	apolipoprotein A-II	Mus musculus	52-57
22123309-9	2012	DDD.Cg-A(y) showed a low CHO level, although it had Apoa2(b), which was a CHO-increasing allele at the Apoa2 locus.	cho	74-77	apolipoprotein A-II	Mus musculus	103-108
24198583-13	2012	TNF-alpha concentrations were only significantly (P = 0.045) elevated post-exercise with the CHO-alone solution.	cho	93-96	tumor necrosis factor	Homo sapiens	0-9
24198583-14	2012	A significant (P < 0.05) elevation of IL-6 was seen immediately post-exercise and 12 hours post-exercise with both the CHO-alone and 4:1 CHO/PRO solutions.	cho	122-125	interleukin 6	Homo sapiens	41-45
24198583-14	2012	A significant (P < 0.05) elevation of IL-6 was seen immediately post-exercise and 12 hours post-exercise with both the CHO-alone and 4:1 CHO/PRO solutions.	cho	140-143	interleukin 6	Homo sapiens	41-45
22204782-5	2012	A phosphatidylinositol 3-kinase inhibitor, wortmannin, attenuated the third phase of AR change in CHO cells expressing wild-type EGFR.	cho	98-101	epidermal growth factor receptor	Cricetulus griseus	129-133
21692749-7	2011	Furthermore, either PLCzeta-transfected CHO cells or derived cell extracts could specifically cause cytoplasmic Ca2+ oscillations when microinjected into mouse eggs.	cho	40-43	phospholipase C zeta 1	Homo sapiens	20-27
22031472-10	2012	In CHO cells, this coincident signaling mechanism is involved in DOR-induced glucose uptake.	cho	3-6	tumor protein p53 inducible nuclear protein 2	Homo sapiens	65-68
21862943-1	2011	OBJECTIVE: The biological significance of [11C]choline (CHO) uptake in human tumours is unclear and probably linked to choline kinase-alpha (CHKalpha) expression and cell proliferation.	cho	56-59	choline kinase alpha	Homo sapiens	119-139
21862943-1	2011	OBJECTIVE: The biological significance of [11C]choline (CHO) uptake in human tumours is unclear and probably linked to choline kinase-alpha (CHKalpha) expression and cell proliferation.	cho	56-59	choline kinase alpha	Homo sapiens	141-149
21862943-9	2011	A statistically significant association was found between CHO-PET variables and categorical scores of cytoplasmic CHKalpha intensity and between FLT-PET and LIKi67 (P<0.05, one-way analysis of variance).	cho	58-61	choline kinase alpha	Homo sapiens	114-122
21862943-11	2011	CHO uptake was also found to be related to cytoplasmic CHKalpha expression.	cho	0-3	choline kinase alpha	Homo sapiens	55-63
21843500-6	2011	Treatment of menadione increased the expressions of iNOS and qp91 phox, enhanced the activities of SOD and catalase in the wild-type CHO cells but inhibited the activity of glutathione peroxidase in the cholesterol accumulated CHO cells.	cho	133-136	catalase	Cricetulus griseus	107-115
21569553-7	2011	In CHO cells, the deletion of the C-terminal calmodulin-binding site of TRPV1 resulted in greater association with AKAP150, and increased channel activity.	cho	3-6	LOC100759184	Cricetulus griseus	45-55
22121778-4	2011	Similarly in co-expressing CHO or HEK293 cells, HA-KOR and Myc-ORL1 were almost exclusively confined to the membranes, revealing extensive colocalization.	cho	27-30	opioid receptor kappa 1	Homo sapiens	51-54
22121778-4	2011	Similarly in co-expressing CHO or HEK293 cells, HA-KOR and Myc-ORL1 were almost exclusively confined to the membranes, revealing extensive colocalization.	cho	27-30	opioid related nociceptin receptor 1	Homo sapiens	63-67
21917155-9	2011	RESULTS: IDO transgenic CHO cells yielded high levels of IDO enzymatic activity, resulting in complete depletion of tryptophan from the culture medium.	cho	24-27	indoleamine 2,3-dioxygenase 1	Homo sapiens	9-12
21917155-9	2011	RESULTS: IDO transgenic CHO cells yielded high levels of IDO enzymatic activity, resulting in complete depletion of tryptophan from the culture medium.	cho	24-27	indoleamine 2,3-dioxygenase 1	Homo sapiens	57-60
21445860-2	2011	CHO cells transformed with the rat 4S PAH receptor/GNMT expression vector had twice the induction level of luciferase activity with respect to wild-type CHO cells in concert with previously published reports that the 4S PAH receptor/GNMT mediates benzo[a]pyrene induction of CYP1A1 gene expression.	cho	0-3	glycine N-methyltransferase	Rattus norvegicus	51-55
21445860-2	2011	CHO cells transformed with the rat 4S PAH receptor/GNMT expression vector had twice the induction level of luciferase activity with respect to wild-type CHO cells in concert with previously published reports that the 4S PAH receptor/GNMT mediates benzo[a]pyrene induction of CYP1A1 gene expression.	cho	0-3	glycine N-methyltransferase	Cricetulus griseus	233-237
21795794-3	2011	Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry-based analysis of the extracellular region of the cytotoxic T-lymphocyte antigen 4 (CTLA-4; CD152) homodimer expressed in long-term CHO cell cultures in the presence of kifunensine revealed that the inhibitor restricted CTLA-4 glycan processing to Man9GlcNAc2 and Man5GlcNAc2 structures.	cho	209-212	cytotoxic T-lymphocyte protein 4	Cricetulus griseus	127-159
21795794-3	2011	Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry-based analysis of the extracellular region of the cytotoxic T-lymphocyte antigen 4 (CTLA-4; CD152) homodimer expressed in long-term CHO cell cultures in the presence of kifunensine revealed that the inhibitor restricted CTLA-4 glycan processing to Man9GlcNAc2 and Man5GlcNAc2 structures.	cho	209-212	cytotoxic T-lymphocyte protein 4	Cricetulus griseus	161-167
21525007-6	2011	Most strikingly, Mek1/2 inhibition promotes SR-BI degradation in SR-BI-overexpressing CHO cells and human HuH7 hepatocytes, which is associated with reduced uptake of radiolabeled and 1,1"-dioctadecyl-3,3,3",3"-tetramethylindocarbocyane-labeled HDL.	cho	86-89	dual specificity mitogen-activated protein kinase kinase 1	Cricetulus griseus	17-23
21525007-6	2011	Most strikingly, Mek1/2 inhibition promotes SR-BI degradation in SR-BI-overexpressing CHO cells and human HuH7 hepatocytes, which is associated with reduced uptake of radiolabeled and 1,1"-dioctadecyl-3,3,3",3"-tetramethylindocarbocyane-labeled HDL.	cho	86-89	scavenger receptor class B member 1	Cricetulus griseus	44-49
21525007-6	2011	Most strikingly, Mek1/2 inhibition promotes SR-BI degradation in SR-BI-overexpressing CHO cells and human HuH7 hepatocytes, which is associated with reduced uptake of radiolabeled and 1,1"-dioctadecyl-3,3,3",3"-tetramethylindocarbocyane-labeled HDL.	cho	86-89	scavenger receptor class B member 1	Cricetulus griseus	65-70
21569553-7	2011	In CHO cells, the deletion of the C-terminal calmodulin-binding site of TRPV1 resulted in greater association with AKAP150, and increased channel activity.	cho	3-6	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	72-77
21095135-7	2011	CHO ingestion significantly reduced post-exercise IL-6 (p<.05) but this had no effect on plasma hepcidin or iron concentration.	cho	0-3	interleukin 6	Homo sapiens	50-54
21144647-9	2011	Univariate statistical analysis revealed greater 1H-MRS-detected Cho content (P=0.0444) and lower normalized NAA/Cho ratio (P=0.0203) in tumors with MIB-1 index 5% and more.	cho	65-68	MIB E3 ubiquitin protein ligase 1	Homo sapiens	149-154
21144647-9	2011	Univariate statistical analysis revealed greater 1H-MRS-detected Cho content (P=0.0444) and lower normalized NAA/Cho ratio (P=0.0203) in tumors with MIB-1 index 5% and more.	cho	113-116	MIB E3 ubiquitin protein ligase 1	Homo sapiens	149-154
20506567-5	2011	Val195 type GPR55 appeared to induce less phosphorylated ERK than Gly195 type GPR55 when CHO cells were treated with anandamide and lysophosphatidylinositol (LPI).	cho	89-92	G-protein coupled receptor 55	Cricetulus griseus	12-17
20506567-5	2011	Val195 type GPR55 appeared to induce less phosphorylated ERK than Gly195 type GPR55 when CHO cells were treated with anandamide and lysophosphatidylinositol (LPI).	cho	89-92	G-protein coupled receptor 55	Cricetulus griseus	78-83
20091739-5	2010	Functional analysis (by siRNA) of five of these candidates identified the valosin-containing protein (VCP) as having a substantial impact on CHO cell growth and viability.	cho	141-144	transitional endoplasmic reticulum ATPase	Cricetulus griseus	74-100
20952497-4	2011	Akt and GSK-3beta phosphorylation mediated via CHO-expressed hD(2L) and hD3 receptors was prevented by pertussis toxin and by inhibitors of insulin-like growth factor-1 receptors as well as phosphatidylinositol 3-kinase and Src.	cho	47-50	AKT serine/threonine kinase 1	Homo sapiens	0-3
20952497-4	2011	Akt and GSK-3beta phosphorylation mediated via CHO-expressed hD(2L) and hD3 receptors was prevented by pertussis toxin and by inhibitors of insulin-like growth factor-1 receptors as well as phosphatidylinositol 3-kinase and Src.	cho	47-50	glycogen synthase kinase 3 beta	Homo sapiens	8-17
20952497-4	2011	Akt and GSK-3beta phosphorylation mediated via CHO-expressed hD(2L) and hD3 receptors was prevented by pertussis toxin and by inhibitors of insulin-like growth factor-1 receptors as well as phosphatidylinositol 3-kinase and Src.	cho	47-50	insulin like growth factor 1	Homo sapiens	140-168
20952497-4	2011	Akt and GSK-3beta phosphorylation mediated via CHO-expressed hD(2L) and hD3 receptors was prevented by pertussis toxin and by inhibitors of insulin-like growth factor-1 receptors as well as phosphatidylinositol 3-kinase and Src.	cho	47-50	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	224-227
20364347-10	2010	IL-1beta increased (P = 0.05) 24 h post-exercise in the high compared to the low CHO condition.	cho	81-84	interleukin 1 beta	Homo sapiens	0-8
20364347-11	2010	There was a trend (P = 0.06) for IL-6 to be elevated in the high compared to the low CHO condition.	cho	85-88	interleukin 6	Homo sapiens	33-37
20043005-3	2010	We hypothesized that the prefrontal levels of N-acetyl-aspartate (NAA), a neuronal marker, and choline-containing compound (Cho), which are related to membrane turnover, would increase with CDP-choline treatment in MA-dependent patients.	cho	124-127	cut like homeobox 1	Homo sapiens	190-193
20043005-7	2010	Generalized estimating equation regression analyses showed that the rate of change in prefrontal NAA (p=0.005) and Cho (p=0.03) levels were greater with CDP-choline treatment than with placebo.	cho	115-118	cut like homeobox 1	Homo sapiens	153-156
20879789-7	2010	Studies in CHO cells specifically expressing LDL-R and SR-BI confirmed CERM-[(3)H]CE uptake by both receptors.	cho	11-14	low-density lipoprotein receptor	Cricetulus griseus	45-50
20708636-5	2010	When intrachromosomal, mitotic recombination was assayed in WRN-depleted CHO cells, a hyperrecombination phenotype was observed, and a small number of aberrant recombinants were generated.	cho	73-76	Werner syndrome ATP-dependent helicase	Cricetulus griseus	60-63
20708636-6	2010	Targeted homologous recombination was also examined in WRN-depleted CHO cells using a plasmid-chromosome targeting assay.	cho	68-71	Werner syndrome ATP-dependent helicase	Cricetulus griseus	55-58
20091739-5	2010	Functional analysis (by siRNA) of five of these candidates identified the valosin-containing protein (VCP) as having a substantial impact on CHO cell growth and viability.	cho	141-144	transitional endoplasmic reticulum ATPase	Cricetulus griseus	102-105
20625486-0	2010	Enhancement of human prolactin synthesis by sodium butyrate addition to serum-free CHO cell culture.	cho	83-86	prolactin	Homo sapiens	21-30
19832729-10	2010	CHO cells transfected with expression plasmids for KCNQ1 and KCNE1 showed an outward rectifying current that was maximal at equimolar plasmids for KCNQ1-KCNE1 and decreased at higher KCNE1 levels.	cho	0-3	potassium voltage-gated channel subfamily KQT member 1	Cricetulus griseus	51-56
19832729-10	2010	CHO cells transfected with expression plasmids for KCNQ1 and KCNE1 showed an outward rectifying current that was maximal at equimolar plasmids for KCNQ1-KCNE1 and decreased at higher KCNE1 levels.	cho	0-3	potassium voltage-gated channel subfamily E member 1	Cricetulus griseus	61-66
19832729-10	2010	CHO cells transfected with expression plasmids for KCNQ1 and KCNE1 showed an outward rectifying current that was maximal at equimolar plasmids for KCNQ1-KCNE1 and decreased at higher KCNE1 levels.	cho	0-3	potassium voltage-gated channel subfamily KQT member 1	Cricetulus griseus	147-152
19832729-10	2010	CHO cells transfected with expression plasmids for KCNQ1 and KCNE1 showed an outward rectifying current that was maximal at equimolar plasmids for KCNQ1-KCNE1 and decreased at higher KCNE1 levels.	cho	0-3	potassium voltage-gated channel subfamily E member 1	Cricetulus griseus	153-158
19832729-10	2010	CHO cells transfected with expression plasmids for KCNQ1 and KCNE1 showed an outward rectifying current that was maximal at equimolar plasmids for KCNQ1-KCNE1 and decreased at higher KCNE1 levels.	cho	0-3	potassium voltage-gated channel subfamily E member 1	Cricetulus griseus	153-158
21364639-4	2010	In CHO cells, it inhibited apoptosis induced by the overexpression of human proapoptotic proteins, Bim and Bax.	cho	3-6	BCL2 like 11	Homo sapiens	99-102
21364639-4	2010	In CHO cells, it inhibited apoptosis induced by the overexpression of human proapoptotic proteins, Bim and Bax.	cho	3-6	BCL2 associated X, apoptosis regulator	Homo sapiens	107-110
21364639-5	2010	alphaA-crystallin inhibited doxorubicin-mediated activation of human procaspase-3 in CHO cells and it activated the PI3K/Akt cell survival pathway by promoting the phosphorylation of PDK1, Akt and phosphatase tensin homologue in HeLa cells.	cho	85-88	caspase 3	Homo sapiens	69-81
19557832-7	2009	Final selection of CHO-specific HKGs include Actr5, Eif3i, Hirip3, Pabpn1, Vezt, Cog1, and Yaf2.	cho	19-22	actin-related protein 5	Cricetulus griseus	45-50
19557832-7	2009	Final selection of CHO-specific HKGs include Actr5, Eif3i, Hirip3, Pabpn1, Vezt, Cog1, and Yaf2.	cho	19-22	eukaryotic translation initiation factor 3 subunit I	Cricetulus griseus	52-57
19557832-7	2009	Final selection of CHO-specific HKGs include Actr5, Eif3i, Hirip3, Pabpn1, Vezt, Cog1, and Yaf2.	cho	19-22	HIRA-interacting protein 3	Cricetulus griseus	59-65
19557832-7	2009	Final selection of CHO-specific HKGs include Actr5, Eif3i, Hirip3, Pabpn1, Vezt, Cog1, and Yaf2.	cho	19-22	LOW QUALITY PROTEIN: polyadenylate-binding protein 2	Cricetulus griseus	67-73
19557832-7	2009	Final selection of CHO-specific HKGs include Actr5, Eif3i, Hirip3, Pabpn1, Vezt, Cog1, and Yaf2.	cho	19-22	vezatin	Cricetulus griseus	75-79
19448142-6	2009	In MOR-CHO membranes, DAMGO caused a 501 +/- 29% stimulation of the basal activity, which was inhibited to 456 +/- 22% by 10 microM SR141716.	cho	7-10	opioid receptor, mu 1	Mus musculus	3-6
19914853-2	2009	Besides carbohydrate counting (CHO), it requires the use of algorithms to adjust prandial insulin doses to the number of CHO portions.	cho	121-124	insulin	Homo sapiens	90-97
19470663-10	2009	To investigate mucin O-GalNAc glycans as substrates of Large, a new CHO mutant Lec15.Lec1 that lacked O-mannose and complex N-glycans was isolated and characterized.	cho	68-71	adhesion G protein-coupled receptor L2	Homo sapiens	79-83
19759354-5	2009	The apparent efficacies of UDP and UDP-glucose were similar, and the EC50 values (74, 33, and 29 nM) for UDP-dependent activation of the P2Y14 receptor in HEK293, CHO, and C6 glioma cells, respectively, were similar to the EC50 values (323, 132, and 72 nM) observed for UDP-glucose.	cho	163-166	purinergic receptor P2Y14	Homo sapiens	137-151
19706823-3	2009	EXPERIMENTAL DESIGN: CHO positron emission tomography was done in 32 individuals with primary or metastatic ER-positive breast cancer.	cho	21-24	estrogen receptor 1	Homo sapiens	3-5
19551877-7	2009	Altogether, the expression of Mcl-1 represents a promising alternative cell engineering strategy to delay apoptosis and increase recombinant protein production in CHO cells.	cho	163-166	induced myeloid leukemia cell differentiation protein Mcl-1	Cricetulus griseus	30-35
19254961-6	2009	In CHO-677 cells deficient in HS biosynthesis, heparin enhanced FGF-2-induced phosphorylation of ERK1/2.	cho	3-6	fibroblast growth factor 2	Cricetulus griseus	64-69
19129463-7	2009	Using online intracellular pH measurements in OATP/Oatp-transfected Chinese Hamster Ovary (CHO)-K1 cells, we could demonstrate the presence of a 4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid-sensitive chloride/bicarbonate exchanger in CHO-K1 cells and that OATP/Oatp-mediated substrate transport is paralleled by bicarbonate efflux.	cho	91-94	solute carrier organic anion transporter family member 1A2	Homo sapiens	46-50
18590515-3	2009	To enhance EPO sialylation, we introduced human alpha2,3-ST (alpha2,3-sialyltransferase) and CMP-SAS (CMP-sialic acid synthase) into recombinant human EPO-producing CHO cells.	cho	165-168	erythropoietin	Homo sapiens	151-154
19507259-0	2009	Enhanced IFNgamma production in adenosine-treated CHO cells: a mechanistic study.	cho	50-53	interferon gamma	Homo sapiens	9-17
19175565-10	2009	Stable CHO cells co-transfected with pcNDA3.1-FVII and pcNDA3.1-hepsin expressed FVII and hepsin mRNA, but there was no expression in the CHO cells transfected with insert free pcDNA3.1.	cho	7-10	LOW QUALITY PROTEIN: serine protease hepsin	Cricetulus griseus	64-70
19175565-10	2009	Stable CHO cells co-transfected with pcNDA3.1-FVII and pcNDA3.1-hepsin expressed FVII and hepsin mRNA, but there was no expression in the CHO cells transfected with insert free pcDNA3.1.	cho	7-10	LOW QUALITY PROTEIN: serine protease hepsin	Cricetulus griseus	90-96
19129463-7	2009	Using online intracellular pH measurements in OATP/Oatp-transfected Chinese Hamster Ovary (CHO)-K1 cells, we could demonstrate the presence of a 4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid-sensitive chloride/bicarbonate exchanger in CHO-K1 cells and that OATP/Oatp-mediated substrate transport is paralleled by bicarbonate efflux.	cho	91-94	solute carrier organic anion transporter family member 1A2	Homo sapiens	51-55
19129463-7	2009	Using online intracellular pH measurements in OATP/Oatp-transfected Chinese Hamster Ovary (CHO)-K1 cells, we could demonstrate the presence of a 4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid-sensitive chloride/bicarbonate exchanger in CHO-K1 cells and that OATP/Oatp-mediated substrate transport is paralleled by bicarbonate efflux.	cho	91-94	solute carrier organic anion transporter family member 1A2	Homo sapiens	262-266
19129463-7	2009	Using online intracellular pH measurements in OATP/Oatp-transfected Chinese Hamster Ovary (CHO)-K1 cells, we could demonstrate the presence of a 4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid-sensitive chloride/bicarbonate exchanger in CHO-K1 cells and that OATP/Oatp-mediated substrate transport is paralleled by bicarbonate efflux.	cho	91-94	solute carrier organic anion transporter family member 1A2	Homo sapiens	267-271
19073604-2	2009	In this study, we investigated CL-P1-mediated binding and ingestion of yeast-derived zymosan bioparticles using Chinese hamster ovary (CHO) cells stably expressing human CL-P1 (CHO/CL-P1) and human vascular endothelial cells constitutively expressed CL-P1.	cho	135-138	cleavage factor polyribonucleotide kinase subunit 1	Homo sapiens	31-36
19269599-7	2009	Simultaneous supplementation with insulin and bFGF synergistically promoted the growth of CHO cells and recombinant M-CSF synthesis in basal DMEM/F12 medium.	cho	90-93	insulin	Cricetulus griseus	34-41
18980580-8	2009	CCTalpha translocation to the NE and intranuclear tubules in CHO-SCAP D443N cells was complete after 1 h exposure to 25OH compared with only partial translocation by 4-6 h in CHO-Mock cells.	cho	61-64	choline-phosphate cytidylyltransferase A	Cricetulus griseus	0-8
18980580-8	2009	CCTalpha translocation to the NE and intranuclear tubules in CHO-SCAP D443N cells was complete after 1 h exposure to 25OH compared with only partial translocation by 4-6 h in CHO-Mock cells.	cho	61-64	sterol regulatory element-binding protein cleavage-activating protein	Cricetulus griseus	65-69
19073604-3	2009	The uptake of zymosan by CHO/CL-P1 was dependent upon the level of CL-P1 expressed on the membrane and was inhibited by cytochalasin D and wortmannin.	cho	25-28	cleavage factor polyribonucleotide kinase subunit 1	Homo sapiens	67-72
18726138-0	2008	SNAP-25 genotype influences NAA/Cho in left hippocampus.	cho	32-35	synaptosome associated protein 25	Homo sapiens	0-7
18442831-11	2008	In conclusion, TRPM2 channels were constitutively activated by H(2)O(2) although we could not detect any inhibitory effect of the antioxidants on H(2)O(2)-induced TRPM2 cation channel currents in CHO cells.	cho	196-199	transient receptor potential cation channel subfamily M member 2	Cricetulus griseus	15-20
18671644-7	2008	RESULTS: In 16 patients harboring macroadenomas without hemorrhage, there was a strong positive linear correlation between metabolite concentrations of Cho and the MIB-1 proliferative cell index (R = 0.819, p < 0.001).	cho	152-155	E3 ubiquitin-protein ligase MIB1	Cricetulus griseus	164-169
18239077-4	2008	Results demonstrated that rat groups provided with any of the three nutritional supplements (CHO, Pro, CP) transiently increased the phosphorylation states of mTOR, 4E-BP1, rpS6, and p70(S6K) compared with EX rats.	cho	93-96	mechanistic target of rapamycin kinase	Rattus norvegicus	159-163
18239077-4	2008	Results demonstrated that rat groups provided with any of the three nutritional supplements (CHO, Pro, CP) transiently increased the phosphorylation states of mTOR, 4E-BP1, rpS6, and p70(S6K) compared with EX rats.	cho	93-96	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	165-171
18239077-4	2008	Results demonstrated that rat groups provided with any of the three nutritional supplements (CHO, Pro, CP) transiently increased the phosphorylation states of mTOR, 4E-BP1, rpS6, and p70(S6K) compared with EX rats.	cho	93-96	ribosomal protein S6	Rattus norvegicus	173-177
18239077-4	2008	Results demonstrated that rat groups provided with any of the three nutritional supplements (CHO, Pro, CP) transiently increased the phosphorylation states of mTOR, 4E-BP1, rpS6, and p70(S6K) compared with EX rats.	cho	93-96	ribosomal protein S6 kinase B1	Rattus norvegicus	187-190
18239077-5	2008	Although CHO, Pro, and CP supplements phosphorylated mTOR and p70(S6K) after exercise, only CP elevated the phosphorylation of rpS6 above all other supplements 30 min postexercise and 4E-BP1 30 and 90 min postexercise.	cho	9-12	mechanistic target of rapamycin kinase	Rattus norvegicus	53-57
18239077-5	2008	Although CHO, Pro, and CP supplements phosphorylated mTOR and p70(S6K) after exercise, only CP elevated the phosphorylation of rpS6 above all other supplements 30 min postexercise and 4E-BP1 30 and 90 min postexercise.	cho	9-12	ribosomal protein S6 kinase B1	Rattus norvegicus	62-65
17703360-4	2008	We showed that Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVM), a specific agonist for FPRL-1, stimulated Ca2+ influx in both U87 and FPRL-1/CHO cells.	cho	130-133	formyl peptide receptor 2	Homo sapiens	76-82
18045853-4	2008	Short-term activation of MOR in Chinese hamster ovary (CHO) cells stably transfected with MOR (MOR-CHO) inhibits AC activity.	cho	55-58	opioid receptor mu 1	Homo sapiens	25-28
18045853-4	2008	Short-term activation of MOR in Chinese hamster ovary (CHO) cells stably transfected with MOR (MOR-CHO) inhibits AC activity.	cho	55-58	opioid receptor mu 1	Homo sapiens	90-93
18045853-4	2008	Short-term activation of MOR in Chinese hamster ovary (CHO) cells stably transfected with MOR (MOR-CHO) inhibits AC activity.	cho	55-58	opioid receptor mu 1	Homo sapiens	90-93
18045853-9	2008	Altered overexpression of AC protein per se was not a confounding factor because MOR-CHO overexpressing AC1, which is inhibited by short-term MOR activation, manifested adaptations to long-term morphine treatment qualitatively identical with those of MOR-CHO.	cho	85-88	opioid receptor mu 1	Homo sapiens	81-84
18045853-9	2008	Altered overexpression of AC protein per se was not a confounding factor because MOR-CHO overexpressing AC1, which is inhibited by short-term MOR activation, manifested adaptations to long-term morphine treatment qualitatively identical with those of MOR-CHO.	cho	85-88	opioid receptor mu 1	Homo sapiens	142-145
18045853-9	2008	Altered overexpression of AC protein per se was not a confounding factor because MOR-CHO overexpressing AC1, which is inhibited by short-term MOR activation, manifested adaptations to long-term morphine treatment qualitatively identical with those of MOR-CHO.	cho	85-88	opioid receptor mu 1	Homo sapiens	142-145
17660385-5	2007	[3H]A-778317 labeled a single class of binding sites in hTRPV1-expressing CHO cell membranes with high affinity (KD = 3.4 nM; Bmax = 4.0 pmol/mg protein).	cho	74-77	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-62
17660385-6	2007	Specific binding of 2 nM [3H]A-778317 to hTRPV1-expressing CHO cell membranes was reversible.	cho	59-62	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-47
17329552-4	2007	SB-612111 and (+/-)J-113397 competitively antagonized the effects of N/OFQ on GTPgamma[(35)S] binding in CHO(hNOP) cell membranes (pK(B), 9.70 and 8.71, respectively) and on cAMP accumulation in CHO(hNOP) cells (pK(B), 8.63 and 7.95, respectively), being per se inactive.	cho	105-108	prepronociceptin	Mus musculus	69-74
17805088-7	2007	Coingestion of CAF/CHO significantly attenuated epinephrine (P<0.05) and IL-6 (P<0.05) responses that occurred after ingestion of CAF alone (CAF/PLA) and significantly attenuated the transient alterations in circulating leukocyte (P<0.05) and neutrophil (P<0.01) counts.	cho	19-22	interleukin 6	Homo sapiens	76-80
17805088-7	2007	Coingestion of CAF/CHO significantly attenuated epinephrine (P<0.05) and IL-6 (P<0.05) responses that occurred after ingestion of CAF alone (CAF/PLA) and significantly attenuated the transient alterations in circulating leukocyte (P<0.05) and neutrophil (P<0.01) counts.	cho	19-22	lysine acetyltransferase 2B	Homo sapiens	136-139
17805088-7	2007	Coingestion of CAF/CHO significantly attenuated epinephrine (P<0.05) and IL-6 (P<0.05) responses that occurred after ingestion of CAF alone (CAF/PLA) and significantly attenuated the transient alterations in circulating leukocyte (P<0.05) and neutrophil (P<0.01) counts.	cho	19-22	lysine acetyltransferase 2B	Homo sapiens	147-154
17295238-11	2007	Following incubation with 1.2 microM PhIP, DNA adduct levels were significantly (P < 0.05) higher in CHO cells transfected with CYP1A2/NAT2*4 versus CYP1A2/NAT2*5B.	cho	104-107	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	131-137
17295238-11	2007	Following incubation with 1.2 microM PhIP, DNA adduct levels were significantly (P < 0.05) higher in CHO cells transfected with CYP1A2/NAT2*4 versus CYP1A2/NAT2*5B.	cho	104-107	arylamine N-acetyltransferase 2	Cricetulus griseus	138-142
17658284-9	2007	These results suggest that caspase-8 and -9 are possibly involved in the apoptotic cell death in batch and fed-batch cultures of CHO cells, whereas caspase-2 is not.	cho	129-132	caspase-8	Cricetulus griseus	27-43
17329552-4	2007	SB-612111 and (+/-)J-113397 competitively antagonized the effects of N/OFQ on GTPgamma[(35)S] binding in CHO(hNOP) cell membranes (pK(B), 9.70 and 8.71, respectively) and on cAMP accumulation in CHO(hNOP) cells (pK(B), 8.63 and 7.95, respectively), being per se inactive.	cho	195-198	prepronociceptin	Mus musculus	69-74
17351017-10	2007	The pathways identified in CHO- and HEK-transfected cells were also used in the murine SN56 neuronal cell line, suggesting that these pathways are also important for RXFP3-mediated signaling in the brain.	cho	27-30	relaxin family peptide receptor 3	Mus musculus	166-171
17220308-5	2007	Here we used SP-A1 (6A(2), 6A(4)) and SP-A2 (1A(0), 1A(1)) allele variants expressed by CHO (Chinese hamster ovary) mammalian cells to study their effect on association and/or internalization of P. aeruginosa by rAMs and/or human AMs (hAMs) and to study if phagocytosis can be modulated differentially and/or more effectively by CHO cell-expressed SP-A variants than by insect-cell expressed SP-A variants.	cho	88-91	surfactant protein A1	Homo sapiens	13-18
17336294-3	2007	Western blot analysis of transfected CHO homogenates showed the same band using both patient purified IgG and anti-GABA(B)R1 antibody.	cho	37-40	gamma-aminobutyric acid (GABA) B receptor, 1	Mus musculus	115-124
17314402-4	2007	The surface GPI-APs isolated from the PGAP2 and -3 double-mutant Chinese hamster ovary (CHO) cells had unsaturated chains, such as oleic, arachidonic, and docosatetraenoic acids in the sn-2 position, whereas those from wild-type CHO cells had exclusively stearic acid, a saturated chain, indicating that the sn-2 chain is exchanged to a saturated chain.	cho	88-91	post-GPI attachment to proteins factor 2	Cricetulus griseus	38-50
17417683-5	2007	The encapsulated endostatin-expressing CHO cells can inhibit the growth of primary tumors in a subcutaneous B16 tumor model when injected into the abdominal cavity of mouse.	cho	39-42	collagen type XVIII alpha 1 chain	Homo sapiens	17-27
17314402-4	2007	The surface GPI-APs isolated from the PGAP2 and -3 double-mutant Chinese hamster ovary (CHO) cells had unsaturated chains, such as oleic, arachidonic, and docosatetraenoic acids in the sn-2 position, whereas those from wild-type CHO cells had exclusively stearic acid, a saturated chain, indicating that the sn-2 chain is exchanged to a saturated chain.	cho	229-232	post-GPI attachment to proteins factor 2	Cricetulus griseus	38-50
17318500-10	2007	However, in CHO cells, PDE4 blunts the cAMP signals of both (-)-noradrenaline and (-)-CGP12177.	cho	12-15	phosphodiesterase 4A	Homo sapiens	23-27
17084093-4	2007	The biotinylation of recombinant Itch in transiently transfected CHO Tet-On cells required biotin supplementation and coexpression of BirA, occurred quantitatively and specifically on the lysine residue of the BioTag, and enabled detection of Itch by Western blot in as little as 10ng of total lysate protein.	cho	65-68	E3 ubiquitin-protein ligase Itchy homolog	Cricetulus griseus	33-37
17084093-4	2007	The biotinylation of recombinant Itch in transiently transfected CHO Tet-On cells required biotin supplementation and coexpression of BirA, occurred quantitatively and specifically on the lysine residue of the BioTag, and enabled detection of Itch by Western blot in as little as 10ng of total lysate protein.	cho	65-68	E3 ubiquitin-protein ligase Itchy homolog	Cricetulus griseus	243-247
17084093-6	2007	Biotinylated Gla-RTK was detectable in as little as 5ng of total lysate protein from transiently transfected CHO Tet-On cells, and exhibited pronounced tyrosine phosphorylation.	cho	109-112	alpha-galactosidase A	Cricetulus griseus	13-16
17220308-5	2007	Here we used SP-A1 (6A(2), 6A(4)) and SP-A2 (1A(0), 1A(1)) allele variants expressed by CHO (Chinese hamster ovary) mammalian cells to study their effect on association and/or internalization of P. aeruginosa by rAMs and/or human AMs (hAMs) and to study if phagocytosis can be modulated differentially and/or more effectively by CHO cell-expressed SP-A variants than by insect-cell expressed SP-A variants.	cho	88-91	surfactant protein A2	Homo sapiens	38-43
17220308-5	2007	Here we used SP-A1 (6A(2), 6A(4)) and SP-A2 (1A(0), 1A(1)) allele variants expressed by CHO (Chinese hamster ovary) mammalian cells to study their effect on association and/or internalization of P. aeruginosa by rAMs and/or human AMs (hAMs) and to study if phagocytosis can be modulated differentially and/or more effectively by CHO cell-expressed SP-A variants than by insect-cell expressed SP-A variants.	cho	88-91	surfactant protein A2	Homo sapiens	13-17
17220308-5	2007	Here we used SP-A1 (6A(2), 6A(4)) and SP-A2 (1A(0), 1A(1)) allele variants expressed by CHO (Chinese hamster ovary) mammalian cells to study their effect on association and/or internalization of P. aeruginosa by rAMs and/or human AMs (hAMs) and to study if phagocytosis can be modulated differentially and/or more effectively by CHO cell-expressed SP-A variants than by insect-cell expressed SP-A variants.	cho	88-91	surfactant protein A2	Homo sapiens	38-42
17220308-11	2007	(iv) CHO cell-expressed SP-A was considerably more active than insect cell-expressed variants.	cho	5-8	surfactant protein A2	Homo sapiens	24-28
16807357-6	2006	In CHO-eNOS cells, NOSTRIN-mediated translocation of eNOS involves caveolin in a process most likely representing caveolar trafficking.	cho	3-6	nostrin	Cricetulus griseus	19-26
16857314-9	2006	Valinomycin-treated CHO cells underwent several apoptotic events, including phosphatidylserine (PS) membrane translocation, caspase-3 activation, and mitochondrial membrane depolarization during the first few hours of exposure.	cho	20-23	caspase-3	Cricetulus griseus	124-133
17014689-3	2006	We determined whether depolymerization of microtubules by Colcemid, which prevents melatonin-induced outgrowths in MT1-expressing CHO cells, also prevents MT1 receptor desensitization by affecting G(alpha)-GTP exchange on G-proteins.	cho	130-133	metallothionein-1	Cricetulus griseus	115-118
16860584-7	2006	CHO cells with both Bax and Bak genes knocked down displayed an extended lifespan as well as higher viable cell densities in fed-batch cultures, both in adherent form on microcarrier beads and in suspension.	cho	0-3	apoptosis regulator BAX	Cricetulus griseus	20-23
16860584-7	2006	CHO cells with both Bax and Bak genes knocked down displayed an extended lifespan as well as higher viable cell densities in fed-batch cultures, both in adherent form on microcarrier beads and in suspension.	cho	0-3	BCL2-antagonist/killer 1	Rattus norvegicus	28-31
17018620-6	2006	In vivo injection of PRL-3-expressing CHO cells into nude mice to form local tumors resulted in the recruitment of host endothelial cells into the tumors and initiation of angiogenesis.	cho	38-41	protein tyrosine phosphatase 4A3	Homo sapiens	21-26
16765324-4	2006	The CHO cells overexpressing NQO2 and mouse keratinocytes expressing or deficient in NQO2 were treated with varying concentrations of mitomycin C (MMC), CB1954, MMC analog BMY25067, EO9, menadione and BP-3,6-quinone, in the absence and presence of NRH.	cho	4-7	ribosyldihydronicotinamide dehydrogenase [quinone]	Cricetulus griseus	29-33
16765324-6	2006	The CHO cells overexpressing higher levels of mouse NQO2 showed significantly increased cytotoxicity to menadione, BP-3,6-quinone and to the anti-tumor drugs MMC and CB1954 when compared to CHO cells expressing endogenous NQO2.	cho	4-7	N-ribosyldihydronicotinamide quinone reductase 2	Mus musculus	52-56
16505160-4	2006	The majority of the KOR in the placenta and FLAG-hKOR in CHO cells, determined by [3H]diprenorphine binding and/or immunoblotting with an anti-FLAG antibody, was present in low-density fractions, coinciding with high levels of caveolin-1 and cholesterol, markers of lipid rafts, which indicated that the KOR is localized in lipid rafts.	cho	57-60	opioid receptor kappa 1	Homo sapiens	20-23
16765324-6	2006	The CHO cells overexpressing higher levels of mouse NQO2 showed significantly increased cytotoxicity to menadione, BP-3,6-quinone and to the anti-tumor drugs MMC and CB1954 when compared to CHO cells expressing endogenous NQO2.	cho	4-7	ribosyldihydronicotinamide dehydrogenase [quinone]	Cricetulus griseus	222-226
16546225-1	2006	SB-616234-A possesses high affinity for human 5-HT1B receptors stably expressed in Chinese hamster ovary (CHO) cells (pKi 8.3+/-0.2), and is over 100-fold selective for a range of molecular targets except h5-HT1) receptors (pKi 6.6+/-0.1).	cho	106-109	5-hydroxytryptamine receptor 1B	Homo sapiens	46-52
16433632-4	2006	Interestingly, Src-family kinase inhibitors prevented beta2-integrin-mediated (i) homotypic PMN adhesion triggered by E-selectin-IgG, (ii) heterotypic CHO-E/PMN adhesion in mixed-cell suspensions, and (iii) firm adhesion of PMN to CHO-E monolayers under physiological flow.	cho	151-154	proto-oncogene tyrosine-protein kinase Src	Cricetulus griseus	15-18
16433632-4	2006	Interestingly, Src-family kinase inhibitors prevented beta2-integrin-mediated (i) homotypic PMN adhesion triggered by E-selectin-IgG, (ii) heterotypic CHO-E/PMN adhesion in mixed-cell suspensions, and (iii) firm adhesion of PMN to CHO-E monolayers under physiological flow.	cho	151-154	hemoglobin, beta adult minor chain	Mus musculus	54-59
16433632-5	2006	Similarly to PMN treated with Src-family kinase inhibitors, PMN from hck-/-fgr-/- and hck-/-fgr-/-lyn-/- mice showed significant impairment of beta2-integrin-mediated adhesion to CHO-E.	cho	179-182	hemoglobin, beta adult minor chain	Mus musculus	143-148
16596397-10	2006	In CHO(hUT) cells hU-II stimulates calcium release from intracellular stores (pEC(50) 8.80) and calcium influx in a PTx-insensitive manner.	cho	3-6	urotensin 2	Homo sapiens	18-23
16505160-4	2006	The majority of the KOR in the placenta and FLAG-hKOR in CHO cells, determined by [3H]diprenorphine binding and/or immunoblotting with an anti-FLAG antibody, was present in low-density fractions, coinciding with high levels of caveolin-1 and cholesterol, markers of lipid rafts, which indicated that the KOR is localized in lipid rafts.	cho	57-60	opioid receptor kappa 1	Homo sapiens	49-53
16505160-4	2006	The majority of the KOR in the placenta and FLAG-hKOR in CHO cells, determined by [3H]diprenorphine binding and/or immunoblotting with an anti-FLAG antibody, was present in low-density fractions, coinciding with high levels of caveolin-1 and cholesterol, markers of lipid rafts, which indicated that the KOR is localized in lipid rafts.	cho	57-60	opioid receptor kappa 1	Homo sapiens	50-53
16091017-1	2005	We prepared CHO (Chinese hamster ovary) cells expressing both IR (insulin receptor) and A1R (A1 adenosine receptor).	cho	12-15	insulin receptor	Cricetulus griseus	62-64
16477370-6	2006	Accordingly, basal PP2A contributed to the phosphorylation of Shc Tyr317 in ErbB4 expressing CHO cells, nevertheless it had been reported that PP2A negatively regulates Shc tyrosine phosphorylation in the EGF- or IGF-I-induced signalling pathways.	cho	93-96	protein phosphatase 2 phosphatase activator	Homo sapiens	19-23
16477370-6	2006	Accordingly, basal PP2A contributed to the phosphorylation of Shc Tyr317 in ErbB4 expressing CHO cells, nevertheless it had been reported that PP2A negatively regulates Shc tyrosine phosphorylation in the EGF- or IGF-I-induced signalling pathways.	cho	93-96	SHC adaptor protein 1	Homo sapiens	62-65
16477370-6	2006	Accordingly, basal PP2A contributed to the phosphorylation of Shc Tyr317 in ErbB4 expressing CHO cells, nevertheless it had been reported that PP2A negatively regulates Shc tyrosine phosphorylation in the EGF- or IGF-I-induced signalling pathways.	cho	93-96	receptor tyrosine-protein kinase erbB-4	Cricetulus griseus	76-81
16477370-6	2006	Accordingly, basal PP2A contributed to the phosphorylation of Shc Tyr317 in ErbB4 expressing CHO cells, nevertheless it had been reported that PP2A negatively regulates Shc tyrosine phosphorylation in the EGF- or IGF-I-induced signalling pathways.	cho	93-96	SHC adaptor protein 1	Homo sapiens	169-172
16530514-8	2006	Cysteine protease-deficient trophozoites could not overcome a protective intact mucus barrier and disrupt LS 174T or HT-29F Cl.16 cell monolayers; however, they readily adhere to and disrupt CHO monolayers devoid of a mucus barrier.	cho	191-194	cathepsin B	Homo sapiens	0-17
16412100-6	2006	Furthermore, wild-type CHO cells showed enhanced secretion of the APP metabolites upon ST6Gal-I overexpression, whereas Lec-2 cells did not, indicating that the secretion enhancement requires sialylation of cellular protein(s).	cho	23-26	beta galactoside alpha 2,6 sialyltransferase 1	Mus musculus	87-95
16324696-6	2005	The antagonist potency was measured in functional assays, i.e., in blocking the bradykinin induced inositolphosphates (IP) accumulation at the human (CHO: pKB 10.3) and guinea pig (colonic myocytes: pKB 10.3) B2 receptor, or in antagonizing the bradykinin induced contractile responses in human (detrusor smooth muscle: pKB 9.9) and guinea pig (ileum longitudinal smooth muscle: pKB 10.1) tissues.	cho	150-153	kininogen 1	Homo sapiens	80-90
16091017-1	2005	We prepared CHO (Chinese hamster ovary) cells expressing both IR (insulin receptor) and A1R (A1 adenosine receptor).	cho	12-15	insulin receptor	Cricetulus griseus	66-82
16226271-8	2005	One of these CIS, designated 00/572, containing CHO cell-derived IFN-beta and formulated with both bovine casein and human serum albumin, could be assigned a potency, consistent for all assay types, of 40,000 international units (IU) per ampoule relative to the IU of the 2nd IS of IFN-beta, Gb23-902-531.	cho	48-51	interferon beta 1	Homo sapiens	65-73
16226271-14	2005	CIS 00/572, containing CHO cell-derived, glycosylated IFN-beta, was clearly shown to be suitable to serve as a primary standard for glycosylated forms of IFN-beta, especially clinical grade IFN-beta-1a products.	cho	23-26	interferon beta 1	Homo sapiens	54-62
16293244-2	2005	A similar blockade was obtained with the human neuropeptide Y Y1 receptor (in CHO or SK-N-MC cells).	cho	78-81	neuropeptide Y	Rattus norvegicus	47-61
15993844-8	2005	vW together with transmembrane domains of TEM-8 (CHO(vW/TM)) and full-length CHO(FL) showed formation of tubule-like structure in CHO cells, whereas the other domains showed no effect.	cho	49-52	ANTXR cell adhesion molecule 1	Homo sapiens	42-47
15383320-8	2004	In CHO cells, recruitment of MAGI-1 to cell contacts required the presence of ESAM.	cho	3-6	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1	Cricetulus griseus	29-35
16002803-9	2005	RESULTS: Plasma insulin responses were higher by 299 +/- 64% and 132 +/- 63% in the CHO+PRO trial than in the CHO trial in the diabetic patients and the matched control subjects, respectively (P < 0.001).	cho	84-87	insulin	Homo sapiens	16-23
16002803-9	2005	RESULTS: Plasma insulin responses were higher by 299 +/- 64% and 132 +/- 63% in the CHO+PRO trial than in the CHO trial in the diabetic patients and the matched control subjects, respectively (P < 0.001).	cho	110-113	insulin	Homo sapiens	16-23
15972493-7	2005	The CHO-produced recombinant 5C12 (r5C12) showed similar specificity and binding affinity to Stx2 as the parent hybridoma-produced 5C12.	cho	4-7	syntaxin-2	Cricetulus griseus	93-97
15585822-6	2004	A PhLP-myc-His construct was purified and phosphorylated by serum-stimulated CHO extract.	cho	77-80	phosducin-like protein	Cricetulus griseus	2-6
15936756-7	2005	Both monoclonal antibody L235 and truncated sMTf inhibited mMTf-stimulated CHO cell motility, migration and invasion.	cho	75-78	melanotransferrin	Mus musculus	59-63
15708852-8	2005	In this study we show the unique association of SHP2 with EGFR in response to IR, with up to a 2.5-fold increase in the direct association of endogenous SHP2 with EGFR-wt in response to 2 gray of IR in both CHO and A431 cells.	cho	207-210	epidermal growth factor receptor	Cricetulus griseus	163-167
15383320-8	2004	In CHO cells, recruitment of MAGI-1 to cell contacts required the presence of ESAM.	cho	3-6	endothelial cell-selective adhesion molecule	Cricetulus griseus	78-82
15296748-7	2004	The differential positioning of Cho organs between the thorax and abdomen is known to be regulated by Hox genes, and we show that the essential Hox cofactor Homothorax, represses Robo2 expression in the abdominal visceral mesoderm.	cho	32-35	tinman	Drosophila melanogaster	102-105
15524322-10	2004	Unfortunately, development of RCA during treatment with CHO cell-derived recombinant erythropoietin proteins was not eliminated as a serious safety concern, even for this feline-specific preparation.	cho	56-59	erythropoietin	Cricetulus griseus	85-99
15284836-3	2004	During a 12:12 light-dark cycle, as compared to control CHO cells, the implantation of encapsulated hANP-producing CHO cells was associated with an increase in the net excretion of water, sodium and potassium, and with a reversal of the advanced circadian phases related to renovascular hypertension in 2K1C rats.	cho	56-59	natriuretic peptide A	Homo sapiens	100-104
15284836-3	2004	During a 12:12 light-dark cycle, as compared to control CHO cells, the implantation of encapsulated hANP-producing CHO cells was associated with an increase in the net excretion of water, sodium and potassium, and with a reversal of the advanced circadian phases related to renovascular hypertension in 2K1C rats.	cho	115-118	natriuretic peptide A	Homo sapiens	100-104
15296748-7	2004	The differential positioning of Cho organs between the thorax and abdomen is known to be regulated by Hox genes, and we show that the essential Hox cofactor Homothorax, represses Robo2 expression in the abdominal visceral mesoderm.	cho	32-35	tinman	Drosophila melanogaster	144-147
15296748-7	2004	The differential positioning of Cho organs between the thorax and abdomen is known to be regulated by Hox genes, and we show that the essential Hox cofactor Homothorax, represses Robo2 expression in the abdominal visceral mesoderm.	cho	32-35	roundabout 2	Drosophila melanogaster	179-184
12849725-2	2003	The toxicity of menadione was significantly reduced in CHO+NQO1 cells compared to wild-type CHO cells, validating the NQO1-overexpression in the CHO+NQO1 transfectant.	cho	55-58	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	59-63
15078871-5	2004	TAF7-deficient cells had decreased capacity for polyamine uptake (20% of CHO cells), decreased AP-1 activation, as well as resistance to MGBG-induced apoptosis.	cho	73-76	transcription initiation factor TFIID subunit 7	Cricetulus griseus	0-4
15078871-6	2004	Stable expression of TAF7 in TAF7-deficient cells restored transport activity (55% of CHO cells), AP-1 gene transactivation (100% of CHO cells), and sensitivity to MGBG-induced apoptosis.	cho	86-89	transcription initiation factor TFIID subunit 7	Cricetulus griseus	21-25
15078871-6	2004	Stable expression of TAF7 in TAF7-deficient cells restored transport activity (55% of CHO cells), AP-1 gene transactivation (100% of CHO cells), and sensitivity to MGBG-induced apoptosis.	cho	86-89	transcription initiation factor TFIID subunit 7	Cricetulus griseus	29-33
15078871-6	2004	Stable expression of TAF7 in TAF7-deficient cells restored transport activity (55% of CHO cells), AP-1 gene transactivation (100% of CHO cells), and sensitivity to MGBG-induced apoptosis.	cho	133-136	transcription initiation factor TFIID subunit 7	Cricetulus griseus	21-25
15078871-6	2004	Stable expression of TAF7 in TAF7-deficient cells restored transport activity (55% of CHO cells), AP-1 gene transactivation (100% of CHO cells), and sensitivity to MGBG-induced apoptosis.	cho	133-136	transcription initiation factor TFIID subunit 7	Cricetulus griseus	29-33
15068397-6	2004	Furthermore, apoptosis in CHO cells induced by the DNA-damaging agent, etoposide, is associated with a fall in the levels of the anti-apoptotic Bcl-2 protein.	cho	26-29	apoptosis regulator Bcl-2	Cricetulus griseus	144-149
12939263-7	2003	In CHO-MR cells, EGFR-expression is up-regulated by aldosterone and inhibited by spironolactone.	cho	3-6	nuclear receptor subfamily 3 group C member 2	Homo sapiens	7-9
12939263-7	2003	In CHO-MR cells, EGFR-expression is up-regulated by aldosterone and inhibited by spironolactone.	cho	3-6	epidermal growth factor receptor	Homo sapiens	17-21
12939263-8	2003	CHO-MR cells but not CHO-GR cells respond with ERK1/2 phosphorylation to EGF exposure.	cho	0-3	nuclear receptor subfamily 3 group C member 2	Homo sapiens	4-6
12939263-8	2003	CHO-MR cells but not CHO-GR cells respond with ERK1/2 phosphorylation to EGF exposure.	cho	0-3	mitogen-activated protein kinase 3	Homo sapiens	47-53
14642351-8	2003	In contrast, wild-type Bcl-x(L) expressing CHO cells were found to arrest growth but maintain viability following serum withdrawal.	cho	43-46	BCL2 like 1	Homo sapiens	23-31
12969637-7	2003	CHO supernatant containing equine recombinant (eqr) IL-5, like the human ortholog (hrIL-5), induced concentration dependent equine eosinophil adherence to autologous serum-coated plastic (9.7+/-1.5% with a 1:100 dilution of eqrIL-5 and 9.1+/-1.6% adherence with 1 nM hrIL-5; n = 4).	cho	0-3	interleukin 5	Equus caballus	52-56
12941902-6	2003	By contrast, dextran sulfate inhibited gp46-Fc binding to GAG-negative cells such as CHO 2244, CHO 2241, and Jurkat T cells weakly or not at all.	cho	85-88	serpin family H member 1	Homo sapiens	39-43
15235331-8	2004	Peak postexercise plasma CPK levels, indicative of muscle damage, were 83% lower after the CHO+P trial (216.3 +/- 122.0 U x L) than the CHO trial (1318.1 +/- 1935.6 U x L).	cho	91-94	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	25-28
15379248-10	2004	The results demonstrate that HA-NTM is expressed on the surface of CHO cells and could strengthen the aggregation of CHO-NTM cells.	cho	67-70	neurotrimin	Cricetulus griseus	32-35
14967869-1	2003	The effect of carbohydrate supplementation (CHO) on interleukin 2 (IL-2) and interleukin 5 (IL-5) secretion following acute resistance exercise was examined in 9 resistance-trained males.	cho	44-47	interleukin 2	Homo sapiens	52-65
14967869-1	2003	The effect of carbohydrate supplementation (CHO) on interleukin 2 (IL-2) and interleukin 5 (IL-5) secretion following acute resistance exercise was examined in 9 resistance-trained males.	cho	44-47	interleukin 2	Homo sapiens	67-71
14967869-7	2003	IL-2 secretion was significantly decreased at POST for both the PLC and CHO groups.	cho	72-75	interleukin 2	Homo sapiens	0-4
12915534-6	2003	Nonpermissive CHO cells were rendered permissive to Ad11 infection upon transfection with CD46-cDNA.	cho	14-17	membrane cofactor protein	Cricetulus griseus	90-94
12974619-7	2003	These results indicate that TC induces apoptosis of CHO cell by activating the mitochondrion-mediated apoptotic pathway involving the proteins of Bcl-2 family and cytochrome c.	cho	52-55	apoptosis regulator Bcl-2	Cricetulus griseus	146-151
12974619-7	2003	These results indicate that TC induces apoptosis of CHO cell by activating the mitochondrion-mediated apoptotic pathway involving the proteins of Bcl-2 family and cytochrome c.	cho	52-55	cytochrome c	Cricetulus griseus	163-175
12849725-5	2003	Altogether, these results can be explained by the hypothesis that both wild-type CHO and CHO+NQO1 cells contain sufficient NQO1 activity for optimal protection against the pro-oxidant effect of quercetin on cell proliferation.	cho	81-84	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	123-127
12849725-5	2003	Altogether, these results can be explained by the hypothesis that both wild-type CHO and CHO+NQO1 cells contain sufficient NQO1 activity for optimal protection against the pro-oxidant effect of quercetin on cell proliferation.	cho	89-92	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	93-97
12849725-5	2003	Altogether, these results can be explained by the hypothesis that both wild-type CHO and CHO+NQO1 cells contain sufficient NQO1 activity for optimal protection against the pro-oxidant effect of quercetin on cell proliferation.	cho	89-92	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	123-127
12849725-2	2003	The toxicity of menadione was significantly reduced in CHO+NQO1 cells compared to wild-type CHO cells, validating the NQO1-overexpression in the CHO+NQO1 transfectant.	cho	55-58	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	118-122
12849725-2	2003	The toxicity of menadione was significantly reduced in CHO+NQO1 cells compared to wild-type CHO cells, validating the NQO1-overexpression in the CHO+NQO1 transfectant.	cho	55-58	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	118-122
12739005-6	2003	Forced expression of NADE in CHO (Chinese hamster ovary) cells and MDA-MB-231 human breast cancer cells had little effect on the growth of the cells in vitro, while it dramatically suppressed cellular growth in vivo.	cho	29-32	brain expressed X-linked 3	Mus musculus	21-25
12801231-8	2003	For example, the Ant-4,4,4-tetraamine conjugate displayed IC(50) values of 11 microM in CHO cells and 33 microM in CHO-MG cells, a PAT-deficient cell line.	cho	88-91	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31	Mus musculus	17-22
12473645-7	2003	The (125)I-AGE-BSA binding to CHO-FEEL-1 and CHO-FEEL-2 cells was effectively inhibited by Ac-LDL and polyanionic SR-A inhibitors such as fucoidan, polyinosinic acids, and dextran sulfate but not by native LDL, oxidized LDL, or HDL.	cho	30-33	stabilin 1	Homo sapiens	34-40
12731067-4	2003	In addition, interaction of lipid A and CD55 was shown by co-immuno-precipitation of these molecules from CHO-CD55 cells after incubation with lipid A and anti-lipid A monoclonal antibody, as well as by fluorescence resonance energy transfer (FRET) analysis in human monocytes.	cho	106-109	CD55 molecule (Cromer blood group)	Homo sapiens	40-44
12731067-4	2003	In addition, interaction of lipid A and CD55 was shown by co-immuno-precipitation of these molecules from CHO-CD55 cells after incubation with lipid A and anti-lipid A monoclonal antibody, as well as by fluorescence resonance energy transfer (FRET) analysis in human monocytes.	cho	106-109	CD55 molecule (Cromer blood group)	Homo sapiens	110-114
12610012-7	2003	RESULTS: Insulin responses were dramatically increased in the CHO+PRO trial in both the type 2 diabetic and control groups (189 and 114%, respectively) compared with the CHO trial (P < 0.01).	cho	62-65	insulin	Homo sapiens	9-16
12628486-4	2003	Exposure of CHO-MT(1) cells to melatonin (400 pM) for 0.5, 1, 2, 4, and 8 hr significantly increased specific 2-[125I]iodomelatonin (500 pM) binding to hMT(1) melatonin receptors upon 16-hr withdrawal.	cho	12-15	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	16-21
12628486-4	2003	Exposure of CHO-MT(1) cells to melatonin (400 pM) for 0.5, 1, 2, 4, and 8 hr significantly increased specific 2-[125I]iodomelatonin (500 pM) binding to hMT(1) melatonin receptors upon 16-hr withdrawal.	cho	12-15	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	152-157
12604667-6	2003	In contrast, short exposure of CHO-MT(1) cells to melatonin induced a small decrease in specific 2-[(125)I]iodomelatonin binding (34.2 +/- 13.0%, n = 5) without either desensitization or receptor internalization.	cho	31-34	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	35-40
12177211-7	2002	Neuronal Kir3 channels and NCAM isoforms are associated with cholesterol-rich microdomains (lipid rafts) in CHO cells and in isolated brain membranes.	cho	108-111	neural cell adhesion molecule 1	Mus musculus	27-31
12453879-7	2002	Furthermore, our data showed that the EC2 sequence (173)LETFTVKSCPDAIKEVFDNK(192) was largely responsible for the CD9-mediated CHO cell phenotype.	cho	127-130	CD9 antigen	Cricetulus griseus	114-117
12429349-3	2002	The level of NQO1 over-expression ranged from 14 to 29 times the NQO1 activity in the wild-type CHO cells.	cho	96-99	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	13-17
12414302-2	2002	We hypothesized that the probable glial markers myo-inositol [MI] and choline compounds [CHO] would correlate with cognitive function, CD4 count, and viral loads, but not with serum lipids.	cho	89-92	CD4 molecule	Homo sapiens	135-138
12208049-7	2002	Immunoprecipitation with an anti-GFP monoclonal antibody of a 78 kD a protein from conditioned medium of CHO transfectants confirmed that the CD40(e)-EGFP was secreted in the supernatant.	cho	105-108	CD40 antigen	Mus musculus	142-146
12209096-8	2002	The attachment of CBDBs to CHO cells was blocked by mAbs directed against E-selectin, P-selectin, and VCAM-1, whereas attachment of PBBs was blocked by E-selectin and P-selectin mAbs.	cho	27-30	selectin E	Homo sapiens	74-84
12209096-8	2002	The attachment of CBDBs to CHO cells was blocked by mAbs directed against E-selectin, P-selectin, and VCAM-1, whereas attachment of PBBs was blocked by E-selectin and P-selectin mAbs.	cho	27-30	vascular cell adhesion protein 1	Cricetulus griseus	102-108
12621157-6	2003	In addition, AGE-BSA significantly inhibited the efflux of [3H] cholesterol from CHO-SR-BI cells to HDL.	cho	81-84	scavenger receptor class B member 1	Cricetulus griseus	85-90
12378612-4	2002	Overall, the death-protective impact of bcl-2 and bcl-x(L) in engineered CHO-DG44 was not significant under typical batch-mode operation, an observation that was confirmed by clonal analysis.	cho	73-76	apoptosis regulator Bcl-2	Cricetulus griseus	40-45
12378612-4	2002	Overall, the death-protective impact of bcl-2 and bcl-x(L) in engineered CHO-DG44 was not significant under typical batch-mode operation, an observation that was confirmed by clonal analysis.	cho	73-76	bcl-2-like protein 1	Cricetulus griseus	50-57
12453638-7	2002	On a diet of 10% of CHO and FO, a significant increase in glutathione peroxidase (GPx) and glutathione reductase (GR) activities appears.	cho	20-23	glutathione-disulfide reductase	Rattus norvegicus	91-112
12453638-7	2002	On a diet of 10% of CHO and FO, a significant increase in glutathione peroxidase (GPx) and glutathione reductase (GR) activities appears.	cho	20-23	glutathione-disulfide reductase	Rattus norvegicus	114-116
12453638-8	2002	This combined relationship between the decreased glutathione content and the increased GPx and GR activities in rats fed on CHO and FO confirms the participation of the glutathione redox system in the detoxifying reactions of continuously accumulated peroxides.	cho	124-127	glutathione-disulfide reductase	Rattus norvegicus	95-97
11802796-10	2002	The results demonstrate a biological effect of C2-ceramide in CHO cells by decreasing ARF-1 and PKC-alpha binding to Golgi-enriched membranes, thereby preventing COP1 vesicle formation.	cho	62-65	ADP-ribosylation factor 1	Cricetulus griseus	86-91
12006544-8	2002	CONCLUSIONS: These data demonstrate that CHENSpm is detoxified in PAO-expressing CHO cells, but not in PAO-deficient HCT116 cells, by a mechanism yielding products containing free primary amine groups and implicate PAO as the detoxification enzyme.	cho	81-84	polyamine oxidase	Homo sapiens	66-69
11923102-7	2002	Overexpression of SR-BI in CHO cells resulted in increased cholesterol uptake that was blocked by micromolar concentrations of ezetimibe.	cho	27-30	scavenger receptor class B member 1	Cricetulus griseus	18-23
11935499-5	2002	In CHO cells, production of cAMP with hCG-C was significantly higher than that with other preparations.	cho	3-6	chorionic gonadotropin subunit beta 5	Homo sapiens	38-41
11742535-7	2002	However, when using a CHO mutant defective in the second step of GPI biosynthesis as host, the expression level of GPI-PLD in stable transfectants was increased by 2.5-fold compared with untransfected or empty-vector-transfected cells.	cho	22-25	glycosylphosphatidylinositol specific phospholipase D1	Bos taurus	115-122
12203407-12	2002	DBP-induced CHO cell cytotoxicity was not related to mutagenic potency in S. typhimurium.	cho	12-15	D site-binding protein	Cricetulus griseus	0-3
12081328-10	2002	Finally, when Pc 4-loaded CHO cells were exposed to activating red light, apoptosis was induced; Pc 4-PDT was less effective in causing apoptosis in a companion cell line overexpressing the antiapoptotic protein Bcl-2.	cho	26-29	apoptosis regulator Bcl-2	Cricetulus griseus	212-217
11801723-7	2002	Importantly, introduction of permeabilized post-ODP, but not pre-ODP, CHO nuclei into licensing-deficient Xenopus egg extracts resulted in the preservation of a significant degree of DHFR origin specificity, implying that the previously documented lack of specific origin selection in permeabilized nuclei is at least partially due to the licensing of new initiation sites by proteins in the Xenopus egg extracts.	cho	70-73	dihydrofolate reductase L homeolog	Xenopus laevis	183-187
11473122-6	2001	They also inhibited 125I-FGF2 binding to FGFR1-overexpressing HSPG-bearing CHO cells and adult bovine aortic endothelial cells.	cho	75-78	fibroblast growth factor 2	Cricetulus griseus	25-29
11600432-5	2001	Up to 1 nM ET-1, the level of the formation of inositol phosphates (IPs) was low and similar in both cell types, but, at 10 nM ET-1, it was far greater in CHO-ET(A) than in CHO-ET(B).	cho	155-158	endothelin-1	Cricetulus griseus	127-131
11600432-6	2001	These results show that, in CHO-ET(A) and CHO-ET(B), ET-1 up to 10 nM activated the same Ca(2+) entry channels: 0.1 nM ET-1 activated NSCC-1, and ET-1 > or = 1 nM activated NSCC-1 and NSCC-2.	cho	28-31	endothelin-1	Cricetulus griseus	53-57
11600432-6	2001	These results show that, in CHO-ET(A) and CHO-ET(B), ET-1 up to 10 nM activated the same Ca(2+) entry channels: 0.1 nM ET-1 activated NSCC-1, and ET-1 > or = 1 nM activated NSCC-1 and NSCC-2.	cho	28-31	endothelin-1	Cricetulus griseus	119-123
11600432-6	2001	These results show that, in CHO-ET(A) and CHO-ET(B), ET-1 up to 10 nM activated the same Ca(2+) entry channels: 0.1 nM ET-1 activated NSCC-1, and ET-1 > or = 1 nM activated NSCC-1 and NSCC-2.	cho	28-31	endothelin-1	Cricetulus griseus	119-123
11600432-6	2001	These results show that, in CHO-ET(A) and CHO-ET(B), ET-1 up to 10 nM activated the same Ca(2+) entry channels: 0.1 nM ET-1 activated NSCC-1, and ET-1 > or = 1 nM activated NSCC-1 and NSCC-2.	cho	42-45	endothelin-1	Cricetulus griseus	53-57
11600432-6	2001	These results show that, in CHO-ET(A) and CHO-ET(B), ET-1 up to 10 nM activated the same Ca(2+) entry channels: 0.1 nM ET-1 activated NSCC-1, and ET-1 > or = 1 nM activated NSCC-1 and NSCC-2.	cho	42-45	endothelin-1	Cricetulus griseus	119-123
11600432-6	2001	These results show that, in CHO-ET(A) and CHO-ET(B), ET-1 up to 10 nM activated the same Ca(2+) entry channels: 0.1 nM ET-1 activated NSCC-1, and ET-1 > or = 1 nM activated NSCC-1 and NSCC-2.	cho	42-45	endothelin-1	Cricetulus griseus	119-123
11740152-6	2001	We also demonstrated that VEGF was involved in CHO-ET-1-mediated angiogenesis, by using a specific inhibitor of VEGF tyrosine kinase receptor activity (PTK787/ZK 222584), which abolished CHO-ET-1 nodule formation and CAM neovascularization.	cho	47-50	vascular endothelial growth factor A	Gallus gallus	26-30
11740152-6	2001	We also demonstrated that VEGF was involved in CHO-ET-1-mediated angiogenesis, by using a specific inhibitor of VEGF tyrosine kinase receptor activity (PTK787/ZK 222584), which abolished CHO-ET-1 nodule formation and CAM neovascularization.	cho	47-50	endothelin-1	Cricetulus griseus	51-55
11740152-6	2001	We also demonstrated that VEGF was involved in CHO-ET-1-mediated angiogenesis, by using a specific inhibitor of VEGF tyrosine kinase receptor activity (PTK787/ZK 222584), which abolished CHO-ET-1 nodule formation and CAM neovascularization.	cho	47-50	vascular endothelial growth factor A	Gallus gallus	112-116
11740152-6	2001	We also demonstrated that VEGF was involved in CHO-ET-1-mediated angiogenesis, by using a specific inhibitor of VEGF tyrosine kinase receptor activity (PTK787/ZK 222584), which abolished CHO-ET-1 nodule formation and CAM neovascularization.	cho	47-50	endothelin-1	Cricetulus griseus	191-195
11740152-6	2001	We also demonstrated that VEGF was involved in CHO-ET-1-mediated angiogenesis, by using a specific inhibitor of VEGF tyrosine kinase receptor activity (PTK787/ZK 222584), which abolished CHO-ET-1 nodule formation and CAM neovascularization.	cho	187-190	vascular endothelial growth factor A	Gallus gallus	26-30
11740152-6	2001	We also demonstrated that VEGF was involved in CHO-ET-1-mediated angiogenesis, by using a specific inhibitor of VEGF tyrosine kinase receptor activity (PTK787/ZK 222584), which abolished CHO-ET-1 nodule formation and CAM neovascularization.	cho	187-190	endothelin-1	Cricetulus griseus	51-55
11740152-6	2001	We also demonstrated that VEGF was involved in CHO-ET-1-mediated angiogenesis, by using a specific inhibitor of VEGF tyrosine kinase receptor activity (PTK787/ZK 222584), which abolished CHO-ET-1 nodule formation and CAM neovascularization.	cho	187-190	vascular endothelial growth factor A	Gallus gallus	112-116
11831870-4	2001	We describe a CHO subline capable of delivering potent CD28-independent costimulation to murine T cells and the generation of monoclonal antibodies against these CHO cells that inhibited this costimulatory activity.	cho	14-17	CD28 antigen	Mus musculus	55-59
11473122-6	2001	They also inhibited 125I-FGF2 binding to FGFR1-overexpressing HSPG-bearing CHO cells and adult bovine aortic endothelial cells.	cho	75-78	fibroblast growth factor receptor 1	Cricetulus griseus	41-46
11473122-6	2001	They also inhibited 125I-FGF2 binding to FGFR1-overexpressing HSPG-bearing CHO cells and adult bovine aortic endothelial cells.	cho	75-78	LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein	Cricetulus griseus	62-66
11488908-6	2001	When CHO cells were transfected with C-terminal truncated EGFR lacking three NPXY motifs responsible for direct binding to phosphotyrosine-binding domains of IRSs, no effect of EGF could be observed.	cho	5-8	epidermal growth factor receptor	Homo sapiens	58-62
11692231-3	2001	Using the two-electrode voltage-clamp technique in Xenopus oocytes and the patch-clamp technique (whole cell configuration) in CHO cells, hKv1.5 was inhibited by S9947 with IC50 values of 0.65 microM and 0.42 microM, respectively.	cho	127-130	potassium voltage-gated channel subfamily A member 5	Homo sapiens	138-144
11340077-11	2001	Expression of Elk-1 converts CHO cells into a phenotype in which prolactin gene expression is increased by insulin treatment.	cho	29-32	ETS domain-containing protein Elk-1	Cricetulus griseus	14-19
11340077-11	2001	Expression of Elk-1 converts CHO cells into a phenotype in which prolactin gene expression is increased by insulin treatment.	cho	29-32	insulin	Cricetulus griseus	107-114
11402249-9	2001	Plasma glucose was significantly increased POST in CHO compared to PLC.	cho	51-54	solute carrier family 35 member G1	Homo sapiens	43-47
11488908-6	2001	When CHO cells were transfected with C-terminal truncated EGFR lacking three NPXY motifs responsible for direct binding to phosphotyrosine-binding domains of IRSs, no effect of EGF could be observed.	cho	5-8	LOW QUALITY PROTEIN: pro-epidermal growth factor	Cricetulus griseus	58-61
11018749-6	2000	In addition, we observed that the AP-d/tPRP probe bound to the surface of Chinese hamster ovary (CHO) cells but not to heparan sulfate-deficient CHO-pgsD-677 cells.	cho	97-100	prolactin family 8, subfamily A, member 2	Rattus norvegicus	37-43
11325803-14	2001	Membranes from NPFFR expressing CHO cells bound GTP gamma[(35)S] in the presence of SQA-NPFF.	cho	32-35	pro-FMRFamide-related neuropeptide FF	Cricetulus griseus	15-19
11358332-2	2001	Agonist binding affinities were regulated more robustly by sodium and guanine nucleotide in W284L/CHO than in hDOR/ CHO cell membranes.	cho	116-119	tumor protein p53 inducible nuclear protein 2	Homo sapiens	110-114
11113155-6	2001	SLP-76 expression increased lamellipodia formation induced by Syk and Vav1 in adherent CHO cells (p < 0.001).	cho	87-90	lymphocyte cytosolic protein 2	Mus musculus	0-6
11113155-6	2001	SLP-76 expression increased lamellipodia formation induced by Syk and Vav1 in adherent CHO cells (p < 0.001).	cho	87-90	proto-oncogene vav	Cricetulus griseus	70-74
11115407-7	2001	20-30-fold less potent than S1P for the displacement of [(3)H]S1P binding and inositol phosphate response in Edg-5-expressing CHO cells, as was the case for AoSMCs.	cho	126-129	sphingosine-1-phosphate receptor 2	Rattus norvegicus	109-114
11511814-3	2000	Normal CHO cells primarily produced hIFN-gamma having biantennary sugar chains, whereas a CHO clone, designated IM4/Vh, transfected with GnT-V, primarily produced hIFN-gamma having GlcNAcbeta1-6 branched triantennary sugar chains when sialylation was incomplete and an increase in poly-N-acetyllactosamine (Galbeta1-4GlcNAcbeta1-3)n was observed.	cho	90-93	immunoregulatory 4	Mus musculus	112-115
11511814-3	2000	Normal CHO cells primarily produced hIFN-gamma having biantennary sugar chains, whereas a CHO clone, designated IM4/Vh, transfected with GnT-V, primarily produced hIFN-gamma having GlcNAcbeta1-6 branched triantennary sugar chains when sialylation was incomplete and an increase in poly-N-acetyllactosamine (Galbeta1-4GlcNAcbeta1-3)n was observed.	cho	90-93	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A	Cricetulus griseus	137-142
11511814-3	2000	Normal CHO cells primarily produced hIFN-gamma having biantennary sugar chains, whereas a CHO clone, designated IM4/Vh, transfected with GnT-V, primarily produced hIFN-gamma having GlcNAcbeta1-6 branched triantennary sugar chains when sialylation was incomplete and an increase in poly-N-acetyllactosamine (Galbeta1-4GlcNAcbeta1-3)n was observed.	cho	90-93	interferon gamma	Homo sapiens	163-173
11062164-7	2000	Using a cyt c-specific monoclonal antibody, we observed a dose-dependent release of mitochondrial cyt c in cytosolic extracts of CHO cells exposed to apoptogenic doses of sodium chromate.	cho	129-132	cytochrome c	Cricetulus griseus	8-13
11062164-7	2000	Using a cyt c-specific monoclonal antibody, we observed a dose-dependent release of mitochondrial cyt c in cytosolic extracts of CHO cells exposed to apoptogenic doses of sodium chromate.	cho	129-132	cytochrome c	Cricetulus griseus	98-103
11091196-0	2000	CHO expression of a novel human recombinant IgG1 anti-RhD antibody isolated by phage display.	cho	0-3	Rh blood group D antigen	Homo sapiens	54-57
16233043-7	2001	Consequently, the suppression of apoptosis through the maintenance of the membrane potential of mitochondria by VCP or GSH resulted in a marked increase in tPA production by CHO cells in the serum-free and low-serum cultures.	cho	174-177	transitional endoplasmic reticulum ATPase	Cricetulus griseus	112-115
11113626-5	2000	Similar results were seen with SLS keratinocytes, whereas FALDH-deficient CHO cells showed a more profound reduction in radioactive fatty acid to 12+/-2% of normal.	cho	74-77	aldehyde dehydrogenase 3 family member A2	Homo sapiens	58-63
11062734-9	2000	When injected into the tail vein, however, the number of metastatic nodules in the lungs of CHO/IL-17-injected mice was significantly smaller than that of CHO- or CHO/neo-injected mice.	cho	92-95	interleukin 17A	Homo sapiens	96-101
11027159-7	2000	Therefore, in attached CHO cultures, IGF-I alone does not stimulate cell proliferation but is a requirement for growth in serum-free medium in cooperation with transferrin.	cho	23-26	insulin-like growth factor I	Cricetulus griseus	37-42
11011072-7	2000	In many brain diseases, the variation in the Cho signal intensity can be correlated with a stimulation or inhibition of the phospholipase A(2) activity.	cho	45-48	phospholipase A2 group IB	Homo sapiens	124-142
10956365-3	2000	The increase in serum insulin was no different when the protein-CHO and high-CHO treatments were compared, but both were greater than the response recorded for the low-CHO treatment (both P < 0.05).	cho	64-67	insulin	Homo sapiens	22-29
10956365-3	2000	The increase in serum insulin was no different when the protein-CHO and high-CHO treatments were compared, but both were greater than the response recorded for the low-CHO treatment (both P < 0.05).	cho	77-80	insulin	Homo sapiens	22-29
10956365-3	2000	The increase in serum insulin was no different when the protein-CHO and high-CHO treatments were compared, but both were greater than the response recorded for the low-CHO treatment (both P < 0.05).	cho	77-80	insulin	Homo sapiens	22-29
10956365-6	2000	It is concluded, first, that the ingestion of creatine in conjunction with approximately 50 g of protein and CHO is as effective at potentiating insulin release and creatine retention as ingesting creatine in combination with almost 100 g of CHO.	cho	109-112	insulin	Homo sapiens	145-152
10996427-3	2000	In CHO cells treated with GH, a rapid association of tyrosine and serine phosphorylated Stat5a with activated Erk2 is observed.	cho	3-6	signal transducer and activator of transcription 5A	Cricetulus griseus	88-94
10903509-2	2000	Structural analyses by lectin immunoassays and fast atom bombardment mass spectrometry showed that recombinant human glycodelin produced in CHO cells contains only typical CHO-type glycans and is devoid of any of the N, N"-diacetyllactosediamine (lacdiNAc)-based chains previously identified in glycodelin-A (GdA).	cho	140-143	progestagen associated endometrial protein	Homo sapiens	117-127
10825465-2	2000	CHO cells permanently expressing various levels of cDNA-derived P450 reductase and NQO1 were produced.	cho	0-3	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	83-87
10825465-4	2000	In a similar experiment, overexpression of NQO1 significantly protected CHO cells against the cytotoxicity of these quinones.	cho	72-75	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	43-47
10833408-8	2000	Metabolic labeling experiments showed that the recombinant alpha-N-acetylglucosaminidase secreted by CHO cells had only a trace of mannose 6-phosphate, probably derived from contaminating endogenous CHO enzyme.	cho	101-104	alpha-N-acetylglucosaminidase	Cricetulus griseus	59-88
10779678-7	2000	Interferon-gamma purified from the universal host carried 40.4% alpha2,6- and 59.6% alpha2,3-sialic acid residues and showed improved pharmacokinetics in clearance studies when compared to interferon-gamma produced by normal CHO cells.	cho	225-228	interferon gamma	Cricetulus griseus	0-16
10727402-9	2000	Moreover, these experiments provide confirmation that the transfected human 5-HT(1A) receptor induces the production of ROS (superoxide and hydrogen peroxide) in CHO cells, and support the possibility that an NAD(P)H oxidase-like enzyme might be involved in the 5-HT-mediated generation of both superoxide and hydrogen peroxide.	cho	162-165	5-hydroxytryptamine receptor 1A	Homo sapiens	76-93
10658039-8	2000	CHO attenuated (P < 0.05) the decrease in plasma glucose and insulin and the increase in plasma free fatty acids, tryptophan, epinephrine, and cortisol observed during Pl for both phases.	cho	0-3	insulin	Homo sapiens	64-71
10748265-2	2000	The most potent agonist for Chinese hamster ovary (CHO) cells stably expressing recombinant human bradykinin B(1) receptors were Des-Arg(9)-bradykinin (EC(50)=7.9 nM) and Des-Arg(10)-kallidin (EC(50)=8.6 nM), while the most potent agonist for CHO cells expressing human bradykinin B(2) receptors was bradykinin (EC(50)=2.0 nM).	cho	51-54	kininogen 1	Homo sapiens	98-108
10748265-2	2000	The most potent agonist for Chinese hamster ovary (CHO) cells stably expressing recombinant human bradykinin B(1) receptors were Des-Arg(9)-bradykinin (EC(50)=7.9 nM) and Des-Arg(10)-kallidin (EC(50)=8.6 nM), while the most potent agonist for CHO cells expressing human bradykinin B(2) receptors was bradykinin (EC(50)=2.0 nM).	cho	51-54	kininogen 1	Homo sapiens	140-150
10748265-2	2000	The most potent agonist for Chinese hamster ovary (CHO) cells stably expressing recombinant human bradykinin B(1) receptors were Des-Arg(9)-bradykinin (EC(50)=7.9 nM) and Des-Arg(10)-kallidin (EC(50)=8.6 nM), while the most potent agonist for CHO cells expressing human bradykinin B(2) receptors was bradykinin (EC(50)=2.0 nM).	cho	51-54	kininogen 1	Homo sapiens	140-150
10748265-2	2000	The most potent agonist for Chinese hamster ovary (CHO) cells stably expressing recombinant human bradykinin B(1) receptors were Des-Arg(9)-bradykinin (EC(50)=7.9 nM) and Des-Arg(10)-kallidin (EC(50)=8.6 nM), while the most potent agonist for CHO cells expressing human bradykinin B(2) receptors was bradykinin (EC(50)=2.0 nM).	cho	51-54	kininogen 1	Homo sapiens	140-150
10764830-4	2000	The parental CHO cells produced IFN-gamma with biantennary sugar chains mainly.	cho	13-16	interferon gamma	Homo sapiens	32-41
10755521-6	2000	RESULTS: Flowcytometric profiles of the stable CHO and SEC transfectants with C1-INH-PI showed a medium level of expression of these molecules.	cho	47-50	serpin family G member 1	Homo sapiens	78-87
10567027-5	1999	In the CHO experiments, positive results were obtained with Trp-P-1 and PhIP, whereas the other compounds were devoid of activity under all experimental conditions.	cho	7-10	polycystin 1, transient receptor potential channel interacting	Homo sapiens	60-67
10740976-4	2000	In the CHO cells, both fMLP and PAF directly triggered GLUT1 translocation from the intracellular pool to the cell surface, and stimulated glucose uptake.	cho	7-10	solute carrier family 2, facilitated glucose transporter member 1	Cricetulus griseus	55-60
10679247-5	2000	In Edg-6-transfected CHO cells, an increase in cytosolic Ca(2+) concentration in response to S1P or SPC was clearly enhanced without change in the LPA-induced action as compared with the vector-transfected cells.	cho	21-24	sphingosine-1-phosphate receptor 4	Homo sapiens	3-8
19002966-7	2000	These findings indicate, in these serum-containing CHO cell cultures, that overexpression of Bcl-2 results in desirable modifications in culture physiology.	cho	51-54	apoptosis regulator Bcl-2	Cricetulus griseus	93-98
10488073-13	1999	Similarly, in CHO cells MPB compounds have no effect on the intracellular levels of cAMP and ATP or on the activity of various protein phosphatases (PP1, PP2A, PP2C, or alkaline phosphatase).	cho	14-17	AFA1	Homo sapiens	24-27
10484609-8	1999	HL protein mass and enzyme activity were also recovered from the media of a CHO-derivative cell line genetically deficient in ER glucosidase I activity (Lec23) that was transiently transfected with a human HL cDNA.	cho	76-79	lipase C, hepatic type	Homo sapiens	0-2
10471321-8	1999	Our observations show that CD9 dramatically influences CHO cell interactions with Fn and suggest that CD9 has an important role in modulating cell-extracellular matrix interactions.	cho	55-58	CD9 antigen	Cricetulus griseus	27-30
10510460-3	1999	2 E-1 displaced [3H]-diprenorphine ([3H]-DPN) binding in CHO micro and SH-SY5Y membranes with pKi values of 8.02+/-0.09 and 8.54+/-0.13 respectively.	cho	57-60	small nucleolar RNA, H/ACA box 73A	Homo sapiens	2-5
10484609-8	1999	HL protein mass and enzyme activity were also recovered from the media of a CHO-derivative cell line genetically deficient in ER glucosidase I activity (Lec23) that was transiently transfected with a human HL cDNA.	cho	76-79	mannosyl-oligosaccharide glucosidase	Homo sapiens	129-142
10438575-7	1999	Both p27 and bcl-2 appear to be involved in the resumption of growth control accompanying cell adhesion in DMSO-exposed CHO cells.	cho	120-123	apoptosis regulator Bcl-2	Cricetulus griseus	13-18
10423427-2	1999	The 16-kb cDNA encoding the full-length RyR2 was introduced into CHO cells using lipofectAmine and electroporation methods.	cho	65-68	ryanodine receptor 2	Cricetulus griseus	40-44
10456333-2	1999	Human cMOAT was mainly localized in the plasma membrane of CHO/cMOAT and in the apical membrane of LLC/cMOAT.	cho	59-62	ATP binding cassette subfamily C member 2	Homo sapiens	6-11
10420002-8	1999	With extracellular Ca2+, Na+ and Mg2+, the store-operated currents of CHO(CCE1) rectified inwardly in the presence of internal Cs+.	cho	70-73	transient receptor potential cation channel, subfamily C, member 4	Rattus norvegicus	74-78
10400674-7	1999	In CHO cells transfected with mutant Epo-R in which phenylalanine was substituted for individual tyrosines, a significant increase in [Ca]i was observed with mutants Epo-R Y443F and Epo-R Y464F.	cho	3-6	erythropoietin receptor	Cricetulus griseus	37-42
10400674-7	1999	In CHO cells transfected with mutant Epo-R in which phenylalanine was substituted for individual tyrosines, a significant increase in [Ca]i was observed with mutants Epo-R Y443F and Epo-R Y464F.	cho	3-6	erythropoietin receptor	Cricetulus griseus	166-171
10400674-7	1999	In CHO cells transfected with mutant Epo-R in which phenylalanine was substituted for individual tyrosines, a significant increase in [Ca]i was observed with mutants Epo-R Y443F and Epo-R Y464F.	cho	3-6	erythropoietin	Cricetulus griseus	37-40
10429970-3	1999	In mitotic CHO cells, the N protein localized to the perichromosomal sheath and the cytoplasm, as is typical for nucleolin.	cho	11-14	nucleolin	Cricetulus griseus	113-122
10480490-6	1999	SB 203347 (at 0.1-10 microM final concentration) inhibited PLA2 enzymatic activity released by Zn++ -activated CHO cells by up to 60% (P<0.0001).	cho	111-114	phospholipase A2 group IB	Homo sapiens	59-63
10339587-8	1999	Finally, gene transfer of Ly-49DB6 into BALB/c NK cells conferred cytotoxic capacity against CHO cells, thus establishing that the Ly-49D receptor is sufficient to activate NK cells to lyse this target.	cho	93-96	killer cell lectin-like receptor, subfamily A, member 4	Mus musculus	26-32
10228028-5	1999	Under serum-free conditions, CHO and U373 cells expressing mCD14 responded to as little as 0.1 ng/ml of LPS, as measured by NF-kappaB activation as well as ICAM and IL-6 production.	cho	29-32	CD14 antigen	Mus musculus	59-64
10323786-8	1999	However, when incubated with SR-BI-transfected CHO cells, P-HDL showed a 2-fold increase in selective uptake compared with C-HDL.	cho	47-50	scavenger receptor class B member 1	Cricetulus griseus	29-34
10228028-5	1999	Under serum-free conditions, CHO and U373 cells expressing mCD14 responded to as little as 0.1 ng/ml of LPS, as measured by NF-kappaB activation as well as ICAM and IL-6 production.	cho	29-32	interleukin 6	Homo sapiens	165-169
10087037-4	1999	VACV uptake was significantly greater in CHO cells transfected with hPEPT1 than in cells transfected with only the vector, pcDNA3.	cho	41-44	solute carrier family 15 member 1	Homo sapiens	68-74
10037692-5	1999	Our studies demonstrate that the partial receptor complex (GPIb-IX) supports CHO cell tethering and rolling on a bovine or human vWf matrix under flow.	cho	77-80	von Willebrand factor	Homo sapiens	129-132
10102419-8	1999	Subcortical NAA correlated with performance on a variety of neuropsychological tests but not with Centers for Disease Control clinical stage, whereas high-thalamic Cho was associated with low CD4 lymphocyte counts.	cho	164-167	CD4 molecule	Homo sapiens	192-195
10068448-5	1999	It was found that such treatment of CHO cells resulted in a decrease of ADP-ribosyl cyclase activity, as well as immunofluorescence of CD38 on the cell surface.	cho	36-39	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	Cricetulus griseus	135-139
10073666-6	1999	When CHO cells were exposed to 10 microM sodium vanadate, an inhibitor of tyrosine phosphatase, for 24 h before heat shock, the binding of HSF1 to HSE was reduced by a factor of 2 and the level of HSP72 was greatly reduced.	cho	5-8	heat shock factor protein 1	Cricetulus griseus	139-143
10092084-7	1999	Activation of the classical pathway on CHO and CHO.CD46 cells, using factor B-depleted human serum and anti-CHO antibodies, resulted in almost identical single-peak C3b deposition profiles.	cho	39-42	membrane cofactor protein	Cricetulus griseus	51-55
10092084-7	1999	Activation of the classical pathway on CHO and CHO.CD46 cells, using factor B-depleted human serum and anti-CHO antibodies, resulted in almost identical single-peak C3b deposition profiles.	cho	47-50	membrane cofactor protein	Cricetulus griseus	51-55
10092084-7	1999	Activation of the classical pathway on CHO and CHO.CD46 cells, using factor B-depleted human serum and anti-CHO antibodies, resulted in almost identical single-peak C3b deposition profiles.	cho	47-50	membrane cofactor protein	Cricetulus griseus	51-55
9766671-3	1998	We show that treatment of CHO cells with hydrogen peroxide (H2O2) or sodium hypochlorite (NaOCl) increases the levels of APE mRNA and protein.	cho	26-29	DNA-(apurinic or apyrimidinic site) endonuclease	Cricetulus griseus	121-124
10400383-3	1999	Test results showed that 17 had an EC30 value of 2.6 microM, comparable to 2.9 microM of LY295427, in the CHO cell-based LDLR/Luc assay in the presence of 25-hydroxycholesterol.	cho	106-109	low-density lipoprotein receptor	Cricetulus griseus	121-125
10334302-9	1999	Whereas CHO cells expressing the growth hormone receptor showed marked downregulation of ligand binding after exposure to dexamethasone (DEX) or phorbol myristic acid (PMA), PMA had no effect on expression of ObRa or ObRb, and DEX reduced binding to cells expressing ObRb by 15%.	cho	8-11	growth hormone receptor	Cricetulus griseus	33-56
10071773-5	1999	Similarly, CHO cells stably transfected with a cAMP responsive Renilla luciferase reporter were further transfected with the human beta 2-adrenoceptor.	cho	11-14	adrenoceptor beta 2	Homo sapiens	131-150
9837919-5	1998	In contrast, all of the TSHRs synthesized in mutant CHO-Lec1, 2, and 8 cells (mannose-rich, sialic acid-deficient, and galactose-deficient oligosaccharides, respectively) bound TSH and produced cAMP in response to TSH with an affinity and an EC50 similar to those in TSHR expressed in parental CHO cells (CHO-TSHR; sialylated oligosaccharides).	cho	52-55	thyrotropin receptor	Cricetulus griseus	24-28
9838208-6	1998	Human Epo from singly transfected Pro-5 CHO cells induced significant reticulocytosis (7.00+/-1.58%; mean+/-S.D.	cho	40-43	erythropoietin	Homo sapiens	6-9
9804848-8	1998	However, this metabolite inhibited StAR promoter activity in CV-1, COS-1 and CHO cells.	cho	77-80	steroidogenic acute regulatory protein	Homo sapiens	35-39
9820169-8	1998	The truncated ETA receptor-transfected CHO cells did not show binding affinity to endothelin 1 (ET-1) or endothelin 3 (ET-3).	cho	39-42	endothelin receptor type A	Homo sapiens	14-17
9886834-6	1999	NEM exposure of CHO cells, expressing hGHRtr, resulted in a dose-dependent increase in GHBP generation, but only a moderate decrease in cellular hGHRtr.	cho	16-19	growth hormone receptor	Homo sapiens	87-91
9869656-5	1999	Closer examination of one of these clones (CHO-OSBP cells) revealed a >8.5-fold stimulation of sphingomyelin synthesis after a 6-h treatment with 25-hydroxycholesterol compared to 3.5-fold in controls, slightly higher basal levels of sphingomyelin synthesis, and a more rapid response to 25-hydroxycholesterol.	cho	43-46	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	47-51
9799507-8	1998	Reduction of intact CHO cells with tributylphosphine resulted in the rapid release of ACE-JMEGF (but not wild-type ACE) into the medium, suggesting that a proportion of membrane-bound ACE-JMEGF is cleaved but remains cell-associated via disulfide tethering.	cho	20-23	angiotensin-converting enzyme	Cricetulus griseus	86-89
19003411-0	1998	Recombinant insulin-like growth factor-I (IGF-I) production in Super-CHO results in the expression of IGF-I receptor and IGF binding protein 3.	cho	69-72	insulin-like growth factor I	Cricetulus griseus	12-40
19003411-0	1998	Recombinant insulin-like growth factor-I (IGF-I) production in Super-CHO results in the expression of IGF-I receptor and IGF binding protein 3.	cho	69-72	insulin-like growth factor I	Cricetulus griseus	42-47
19003411-0	1998	Recombinant insulin-like growth factor-I (IGF-I) production in Super-CHO results in the expression of IGF-I receptor and IGF binding protein 3.	cho	69-72	insulin-like growth factor I	Cricetulus griseus	102-107
9738646-8	1998	Incubation of purified monocytes with ICAM-1-transfected CHO cells increased PCA from 1.2+/-0.2 to 81.9+/-3.3 mU/10(5) cells (P<0.001 compared with incubation with untransfected CHO cells) after 6 hours.	cho	57-60	intercellular adhesion molecule 1	Cricetulus griseus	38-44
9645940-8	1998	FPR-mediated chemotaxis of the CHO transfectants was partly inhibited by a tyrosine kinase inhibitor, herbimycin A, and blocked by a phosphoinositide 3-kinase inhibitor, wortmannin.	cho	31-34	formyl peptide receptor 1	Homo sapiens	0-3
9698230-7	1998	Finally, sialylation and antennarity structure percentages at the two glycosylation sites were chosen as the quality indicators in process monitoring of interferon-gamma production from a serum-free suspension-batch CHO culture.	cho	216-219	interferon gamma	Cricetulus griseus	153-169
9645940-9	1998	These data suggest that stimulation of CHO FPR transfectants with a gradient of fMLP results in phosphoinositide 3-kinase-dependent chemotactic migration, which is enhanced by binding of activated alpha5beta1 to fibronectin.	cho	39-42	formyl peptide receptor 1	Homo sapiens	43-46
9645940-9	1998	These data suggest that stimulation of CHO FPR transfectants with a gradient of fMLP results in phosphoinositide 3-kinase-dependent chemotactic migration, which is enhanced by binding of activated alpha5beta1 to fibronectin.	cho	39-42	formyl peptide receptor 1	Homo sapiens	80-84
9698071-8	1998	Treatment with 50 microM of reduced polymer of spermine and glutaraldehyde, a selective blocker of the polyamine transport system, reduced MDR activity in mdr-1-transfected CHO cells and restored cellular accumulation of etoposide and taxol to control levels, effects not observed in mdr-1-transfected CHOMGBG cells.	cho	173-176	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	155-160
9717172-1	1998	We isolated and characterized the ERCC1 coding sequence from three Chinese hamster ovary (CHO) parental (CHO-AA8, CHO-AT3-2 and CHO-9) and 10 ERCC1 mutant cell lines.	cho	90-93	DNA excision repair protein ERCC-1	Cricetulus griseus	34-39
9717172-1	1998	We isolated and characterized the ERCC1 coding sequence from three Chinese hamster ovary (CHO) parental (CHO-AA8, CHO-AT3-2 and CHO-9) and 10 ERCC1 mutant cell lines.	cho	105-108	DNA excision repair protein ERCC-1	Cricetulus griseus	34-39
9717172-1	1998	We isolated and characterized the ERCC1 coding sequence from three Chinese hamster ovary (CHO) parental (CHO-AA8, CHO-AT3-2 and CHO-9) and 10 ERCC1 mutant cell lines.	cho	105-108	DNA excision repair protein ERCC-1	Cricetulus griseus	34-39
9611129-12	1998	Finally, ICAM-1-transfected CHO cells were exposed to activated PMNs from a patient with chronic granulomatous disease that caused significant cell lysis, equivalent to that of PMNs from normal donors.	cho	28-31	intercellular adhesion molecule 1	Cricetulus griseus	9-15
9618196-3	1998	In pooled transfectants of CHO, tetracycline induced the expression of beta-galactosidase in 10-30% of cells.	cho	27-30	beta-galactosidase	Cricetulus griseus	71-89
9592397-6	1998	Because activation of apoptosis response is a possible complication in a proliferation-arrested culture, the survival gene bcl-xL was coexpressed with another CDI, p27, found to enable CHO cell-cycle arrest predominantly in G1 phase.	cho	185-188	bcl-2-like protein 1	Cricetulus griseus	123-129
9578554-5	1998	Galanin inhibited forskolin-stimulated cAMP production in GalR1/CHO cells by 70% and in GalR2/CHO cells by 30%, suggesting a strong coupling of GalR1 to Gi and a more modest coupling between GalR2 and Gi.	cho	64-67	galanin peptides	Cricetulus griseus	0-7
9578554-5	1998	Galanin inhibited forskolin-stimulated cAMP production in GalR1/CHO cells by 70% and in GalR2/CHO cells by 30%, suggesting a strong coupling of GalR1 to Gi and a more modest coupling between GalR2 and Gi.	cho	64-67	Galanin receptor type 1	Cricetulus griseus	58-63
9578554-5	1998	Galanin inhibited forskolin-stimulated cAMP production in GalR1/CHO cells by 70% and in GalR2/CHO cells by 30%, suggesting a strong coupling of GalR1 to Gi and a more modest coupling between GalR2 and Gi.	cho	94-97	galanin peptides	Cricetulus griseus	0-7
9450955-4	1998	C-mannosylation of Trp-7 was reduced 10-fold in CHO (Chinese hamster ovary) Lec15 cells, which are deficient in dolichyl-phosphate-mannose (Dol-P-Man) synthase activity, compared with wild-type cells.	cho	48-51	transient receptor potential cation channel subfamily C member 7	Homo sapiens	19-24
9528972-2	1998	In CHO cells expressing wild-type GHR(GHR(1-638)), GH stimulated the expression of c-fos and egr-1, and stimulated 2-deoxyglucose uptake, responses also mediated by endogenous GHR in 3T3-F442A cells.	cho	3-6	growth hormone receptor	Cricetulus griseus	34-37
9528972-2	1998	In CHO cells expressing wild-type GHR(GHR(1-638)), GH stimulated the expression of c-fos and egr-1, and stimulated 2-deoxyglucose uptake, responses also mediated by endogenous GHR in 3T3-F442A cells.	cho	3-6	growth hormone receptor	Cricetulus griseus	38-41
9528972-2	1998	In CHO cells expressing wild-type GHR(GHR(1-638)), GH stimulated the expression of c-fos and egr-1, and stimulated 2-deoxyglucose uptake, responses also mediated by endogenous GHR in 3T3-F442A cells.	cho	3-6	growth hormone receptor	Cricetulus griseus	38-41
9514198-7	1998	In transiently transfected CHO cells, a 5:1 ratio of p75LNTR:trkA cDNAs produced the greatest change in NGF-induced acid secretion.	cho	27-30	beta-nerve growth factor	Cricetulus griseus	104-107
9486409-7	1998	A significant decreased expression of TNF-alpha transgene, endogenous mouse TNF-alpha and IL-1 mRNA was observed in splenocytes of mice treated for 3 or 4 weeks with CHO/IL-4 and CHO/IL-13, and, to a lesser extent, with CHO/IL-10, compared with controls.	cho	166-169	tumor necrosis factor	Mus musculus	38-47
9486409-7	1998	A significant decreased expression of TNF-alpha transgene, endogenous mouse TNF-alpha and IL-1 mRNA was observed in splenocytes of mice treated for 3 or 4 weeks with CHO/IL-4 and CHO/IL-13, and, to a lesser extent, with CHO/IL-10, compared with controls.	cho	166-169	tumor necrosis factor	Mus musculus	76-85
9486409-7	1998	A significant decreased expression of TNF-alpha transgene, endogenous mouse TNF-alpha and IL-1 mRNA was observed in splenocytes of mice treated for 3 or 4 weeks with CHO/IL-4 and CHO/IL-13, and, to a lesser extent, with CHO/IL-10, compared with controls.	cho	166-169	interleukin 1 complex	Mus musculus	90-94
9486409-7	1998	A significant decreased expression of TNF-alpha transgene, endogenous mouse TNF-alpha and IL-1 mRNA was observed in splenocytes of mice treated for 3 or 4 weeks with CHO/IL-4 and CHO/IL-13, and, to a lesser extent, with CHO/IL-10, compared with controls.	cho	166-169	interleukin 10	Mus musculus	224-229
9486409-7	1998	A significant decreased expression of TNF-alpha transgene, endogenous mouse TNF-alpha and IL-1 mRNA was observed in splenocytes of mice treated for 3 or 4 weeks with CHO/IL-4 and CHO/IL-13, and, to a lesser extent, with CHO/IL-10, compared with controls.	cho	179-182	tumor necrosis factor	Mus musculus	38-47
9486409-7	1998	A significant decreased expression of TNF-alpha transgene, endogenous mouse TNF-alpha and IL-1 mRNA was observed in splenocytes of mice treated for 3 or 4 weeks with CHO/IL-4 and CHO/IL-13, and, to a lesser extent, with CHO/IL-10, compared with controls.	cho	179-182	tumor necrosis factor	Mus musculus	76-85
9486409-7	1998	A significant decreased expression of TNF-alpha transgene, endogenous mouse TNF-alpha and IL-1 mRNA was observed in splenocytes of mice treated for 3 or 4 weeks with CHO/IL-4 and CHO/IL-13, and, to a lesser extent, with CHO/IL-10, compared with controls.	cho	179-182	interleukin 1 complex	Mus musculus	90-94
9486409-7	1998	A significant decreased expression of TNF-alpha transgene, endogenous mouse TNF-alpha and IL-1 mRNA was observed in splenocytes of mice treated for 3 or 4 weeks with CHO/IL-4 and CHO/IL-13, and, to a lesser extent, with CHO/IL-10, compared with controls.	cho	179-182	interleukin 13	Mus musculus	183-188
9499380-12	1998	Thus, the overexpression of human alpha-Gal A in CHO cells resulted in different oligosaccharide structures on the secreted and intracellular glycoforms, the highly heterogeneous secreted forms presumably due to the high level expression and impaired glycosylation in the trans- Golgi network, and the predominately Man5-7GlcNAc2 cellular glycoforms resulting from carbohydrate trimming in the lysosome.	cho	49-52	galactosidase alpha	Homo sapiens	34-45
9449617-4	1998	At 37 C, insulin-stimulated insulin receptor substrate-1 (IRS-1) phosphorylation is inhibited by 50% in CHO-IRC860S, whereas Shc phosphorylation remains unaffected.	cho	104-107	insulin receptor	Cricetulus griseus	28-44
9449617-4	1998	At 37 C, insulin-stimulated insulin receptor substrate-1 (IRS-1) phosphorylation is inhibited by 50% in CHO-IRC860S, whereas Shc phosphorylation remains unaffected.	cho	104-107	insulin receptor substrate 1	Cricetulus griseus	58-63
9369956-5	1997	Medium from the transfected CHO cells contained only active monomeric cystatin C indicating that the cystatin C dimer, formed during intracellular trafficking, is converted to monomer at or before secretion.	cho	28-31	cystatin-C	Cricetulus griseus	70-80
9446605-3	1998	Insulin (10(-9)-10(-7) M) inhibited apoptosis induced by serum withdrawal in CHO-R cells in a concentration-dependent manner.	cho	77-80	insulin	Cricetulus griseus	0-7
9369956-5	1997	Medium from the transfected CHO cells contained only active monomeric cystatin C indicating that the cystatin C dimer, formed during intracellular trafficking, is converted to monomer at or before secretion.	cho	28-31	cystatin-C	Cricetulus griseus	101-111
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	65-68	NK3 homeobox 1	Homo sapiens	132-137
9376682-3	1997	Since the compositions and structures of CHOs are important in determining the chemistry, efficiency, and extent of conjugation, the sequences of the CH1-appended CHOs were determined by exoglycosidase digestions and fluorophore-assisted CHO electrophoresis (FACE).	cho	41-44	SUN domain containing ossification factor	Homo sapiens	150-153
9376682-4	1997	The CHO species attached at HCN1 and HCN5 sites in hLL2HCN1 and hLL2HCN5, respectively, were distinct from each other, heterogeneous, and extensively processed.	cho	4-7	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	28-32
9261130-8	1997	Western blot analysis indicated the expression of significant levels of the 4 S protein in the stably transfected CHO cells (CHO-GNMT).	cho	114-117	glycine N-methyltransferase	Cricetulus griseus	129-133
9261130-9	1997	Cytosolic preparations from the CHO-GNMT showed high benzo[a]pyrene (B[a]P) binding but no 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) binding activity when compared with clones transfected with the pMAMneo vector alone (CHO-neo) or the parental CHO cells.	cho	32-35	glycine N-methyltransferase	Cricetulus griseus	36-40
9261130-13	1997	B[a]P-treated CHO-GNMT, expressing the 4 S protein, also showed CYP1A1 protein by Western blotting and exhibited ethoxyresorufin-O-deethylase activity; neither the CHO-neo or parental CHO cells were positive for any of these measures.	cho	14-17	glycine N-methyltransferase	Cricetulus griseus	18-22
9261130-13	1997	B[a]P-treated CHO-GNMT, expressing the 4 S protein, also showed CYP1A1 protein by Western blotting and exhibited ethoxyresorufin-O-deethylase activity; neither the CHO-neo or parental CHO cells were positive for any of these measures.	cho	14-17	cytochrome P450 1A1	Cricetulus griseus	64-70
9242449-7	1997	Mice bearing CHO/TNF tumors that were injected with PTHrP had significantly higher calcium concentrations, increased committed osteoclast progenitors, and mature osteoclasts as well as enhanced bone resorption compared with mice bearing CHO/TNF tumors injected with vehicle or those bearing CHO/- tumors injected with PTHrP or vehicle.	cho	13-16	parathyroid hormone-like peptide	Mus musculus	52-57
9242449-7	1997	Mice bearing CHO/TNF tumors that were injected with PTHrP had significantly higher calcium concentrations, increased committed osteoclast progenitors, and mature osteoclasts as well as enhanced bone resorption compared with mice bearing CHO/TNF tumors injected with vehicle or those bearing CHO/- tumors injected with PTHrP or vehicle.	cho	13-16	parathyroid hormone-like peptide	Mus musculus	318-323
9271353-7	1997	CHO cells with elevated NQO1 generated and maintained higher levels of TQH2 after treatment with TQ relative to NQO1-deficient CHO cells.	cho	0-3	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	24-28
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	65-68	tachykinin receptor 2	Homo sapiens	59-64
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	65-68	tachykinin receptor 2	Homo sapiens	145-150
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	65-68	tachykinin receptor 1	Homo sapiens	230-235
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	65-68	tachykinin receptor 1	Homo sapiens	230-235
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	79-82	tachykinin receptor 1	Homo sapiens	73-78
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	79-82	NK3 homeobox 1	Homo sapiens	132-137
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	79-82	tachykinin receptor 2	Homo sapiens	145-150
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	79-82	tachykinin receptor 1	Homo sapiens	230-235
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	79-82	tachykinin receptor 1	Homo sapiens	230-235
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	79-82	tachykinin receptor 1	Homo sapiens	73-78
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	79-82	NK3 homeobox 1	Homo sapiens	132-137
9145920-7	1997	In CHO cells, 125I-Tyr14-OFQ detected a single affinity state with an intermediate Kd value of 54 pM.	cho	3-6	prepronociceptin	Homo sapiens	25-28
8940341-9	1996	Iodinated CHO-rPL-Iv showed minimal binding to Nb2 lymphoma cells, but at a 500-fold protein concentration rPL-I was able to displace [125I]rPL-I from the lymphoma cell PRL receptor.	cho	10-13	prolactin family 3, subfamily D, member 4	Rattus norvegicus	14-20
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	79-82	tachykinin receptor 2	Homo sapiens	145-150
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	79-82	tachykinin receptor 1	Homo sapiens	230-235
9191956-6	1997	Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding Ki = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding Ki = > 100 microM).	cho	79-82	tachykinin receptor 1	Homo sapiens	230-235
9701054-8	1997	When the CHO cells were given 10 repetitive 20 mM DEA/NO exposures (3 min each), HGPRT mutant frequency was 4.1 x control.	cho	9-12	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	81-86
9079688-14	1997	Additionally, covalent modification of the CHO enzyme by [3H]bromoenol lactone is dependent on active enzyme as is the P388D1 iPLA2.	cho	43-46	phospholipase A2, group VI	Mus musculus	126-131
9287241-8	1997	Comparison with results from other studies suggests that CHO-derived IFN-beta 1a induces less neutralizing antibody than IFN-beta 1b produced in E. coli.	cho	57-60	interferon beta 1	Homo sapiens	69-77
9016877-6	1997	Attachment of S. flexneri to CHO cells can elicit tyrosine phosphorylation of pp125FAK and paxillin, localized accumulation of F-actin, vinculin, and talin, and activation of protein kinase C, which were all blocked by the treatment with C3 transferase.	cho	29-32	vinculin	Cricetulus griseus	136-144
9094218-4	1997	Analysis of this peptide by MS indicated that the recombinant IFN-gamma polypeptide secreted by CHO cells was truncated by at least ten amino acids, initially at Gln133-Met134.	cho	96-99	interferon gamma	Homo sapiens	62-71
8940341-9	1996	Iodinated CHO-rPL-Iv showed minimal binding to Nb2 lymphoma cells, but at a 500-fold protein concentration rPL-I was able to displace [125I]rPL-I from the lymphoma cell PRL receptor.	cho	10-13	prolactin family 3, subfamily D, member 1	Rattus norvegicus	14-19
8940341-9	1996	Iodinated CHO-rPL-Iv showed minimal binding to Nb2 lymphoma cells, but at a 500-fold protein concentration rPL-I was able to displace [125I]rPL-I from the lymphoma cell PRL receptor.	cho	10-13	prolactin family 3, subfamily D, member 1	Rattus norvegicus	107-112
8940341-10	1996	Using recombinant CHO-derived rPL-Iv as standard and antisera against the Bac-rPL-Iv fusion protein, a RIA was developed for rPL-Iv.	cho	18-21	prolactin family 3, subfamily D, member 4	Rattus norvegicus	30-36
8910546-6	1996	CHO.2N-10 and CHO.T (overexpress wild-type insulin receptor) cells have similar insulin binding characteristics, insulin-stimulated autokinase and peptide phosphorylation, and insulin-stimulated pp185/IRS-1 phosphorylation.	cho	0-3	insulin receptor	Cricetulus griseus	43-59
8910546-6	1996	CHO.2N-10 and CHO.T (overexpress wild-type insulin receptor) cells have similar insulin binding characteristics, insulin-stimulated autokinase and peptide phosphorylation, and insulin-stimulated pp185/IRS-1 phosphorylation.	cho	14-17	insulin receptor	Cricetulus griseus	43-59
8895321-3	1996	Similarly, [125I]TSH cross-linking to the surface of intact CHO cells revealed a progressive increase in TSH-binding sites with dihydrofolate reductase minigene amplification, with a 12.8-fold increase in TSHR in TSHR-10,000 vs. TSHR-0 cells.	cho	60-63	thyrotropin receptor	Cricetulus griseus	205-209
8895321-3	1996	Similarly, [125I]TSH cross-linking to the surface of intact CHO cells revealed a progressive increase in TSH-binding sites with dihydrofolate reductase minigene amplification, with a 12.8-fold increase in TSHR in TSHR-10,000 vs. TSHR-0 cells.	cho	60-63	thyrotropin receptor	Cricetulus griseus	213-217
8895321-3	1996	Similarly, [125I]TSH cross-linking to the surface of intact CHO cells revealed a progressive increase in TSH-binding sites with dihydrofolate reductase minigene amplification, with a 12.8-fold increase in TSHR in TSHR-10,000 vs. TSHR-0 cells.	cho	60-63	thyroid stimulating hormone receptor	Homo sapiens	213-217
8620508-5	1996	A dose of O6-bG, which inactivated human AGT, markedly sensitized human MGMT-transfected CHO cells to 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU), whereas mouse MGMT-transfected CHO cells were much more resistant.	cho	89-92	O-6-methylguanine-DNA methyltransferase	Homo sapiens	72-76
8831731-10	1996	Reversible inhibition of cellular CHO [hPGHS-1] and CHO [hPGHS-2] was observed with the nonselective NSAIDs ibuprofen and indomethacin, whereas inhibition by the selective PGHS-2 inhibitor DuP-697 was reversible against hPGHS-1 but irreversible against hPGHS-2.	cho	34-37	prostaglandin-endoperoxide synthase 1	Homo sapiens	39-46
8831731-10	1996	Reversible inhibition of cellular CHO [hPGHS-1] and CHO [hPGHS-2] was observed with the nonselective NSAIDs ibuprofen and indomethacin, whereas inhibition by the selective PGHS-2 inhibitor DuP-697 was reversible against hPGHS-1 but irreversible against hPGHS-2.	cho	52-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	57-64
8831731-10	1996	Reversible inhibition of cellular CHO [hPGHS-1] and CHO [hPGHS-2] was observed with the nonselective NSAIDs ibuprofen and indomethacin, whereas inhibition by the selective PGHS-2 inhibitor DuP-697 was reversible against hPGHS-1 but irreversible against hPGHS-2.	cho	52-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-64
8863849-5	1996	Furthermore, purinergic receptor-mediated PLA2 activation as well as direct activation of PLA2 with melittin reduced CHO/5-HT1B responsiveness.	cho	117-120	phospholipase A2	Cricetulus griseus	90-94
8812832-9	1996	From these studies with CHO-K1 transfectants, we conclude that (i) cysteines 135 and 175 are both necessary for efficient secretion of a biologically active N-terminal BPI fragment, presumably through the formation of a disulfide bond, (ii) cysteine 132 is responsible for dimer formation, and (iii) only the C132A modification yields a stable, biologically active, N-terminal BPI fragment (designated rBPI21) that is free of dimeric species.	cho	24-27	bactericidal permeability increasing protein	Homo sapiens	168-171
8609397-4	1996	Both B7-1- and B7-2-transfected CHO cells, but not CHO control transfectants, were able to costimulate IL-4 production.	cho	32-35	interleukin-4	Cricetulus griseus	103-107
8592004-3	1996	CHO cells, even when acutely acidified, showed higher intracellular pH (pHi) values in a suspension assay than OvCa cells, which confirmed the danger of comparing absolute values of pHi between cell lines.	cho	0-3	glucose-6-phosphate isomerase	Cricetulus griseus	68-70
8592004-3	1996	CHO cells, even when acutely acidified, showed higher intracellular pH (pHi) values in a suspension assay than OvCa cells, which confirmed the danger of comparing absolute values of pHi between cell lines.	cho	0-3	glucose-6-phosphate isomerase	Cricetulus griseus	72-75
8592004-3	1996	CHO cells, even when acutely acidified, showed higher intracellular pH (pHi) values in a suspension assay than OvCa cells, which confirmed the danger of comparing absolute values of pHi between cell lines.	cho	0-3	glucose-6-phosphate isomerase	Cricetulus griseus	182-185
7669585-4	1995	Histological examination of the site of injection of CHO clones transfected with hu-IL-8, hu-MIP-1 alpha or mu-MIP-1 alpha showed predominantly neutrophilic infiltration.	cho	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
7583579-3	1995	In [14C]lyso-PC-labeled or [14C]choline (Cho)-labeled cells, a biphasic activation of PC-specific phospholipase D (PLD) with peak maxima 30 to 60 seconds and 5 to 7 minutes after stimulation with 20 micrograms/mL HDL3 was shown by (1) a 1.5- to 3-fold increase in Cho release, and (3) transphosphatidylation of PC to phosphatidylbutanol in the presence of 0.3% butanol.	cho	41-44	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	115-118
7583579-3	1995	In [14C]lyso-PC-labeled or [14C]choline (Cho)-labeled cells, a biphasic activation of PC-specific phospholipase D (PLD) with peak maxima 30 to 60 seconds and 5 to 7 minutes after stimulation with 20 micrograms/mL HDL3 was shown by (1) a 1.5- to 3-fold increase in Cho release, and (3) transphosphatidylation of PC to phosphatidylbutanol in the presence of 0.3% butanol.	cho	41-44	HDL3	Homo sapiens	213-217
7583579-3	1995	In [14C]lyso-PC-labeled or [14C]choline (Cho)-labeled cells, a biphasic activation of PC-specific phospholipase D (PLD) with peak maxima 30 to 60 seconds and 5 to 7 minutes after stimulation with 20 micrograms/mL HDL3 was shown by (1) a 1.5- to 3-fold increase in Cho release, and (3) transphosphatidylation of PC to phosphatidylbutanol in the presence of 0.3% butanol.	cho	264-267	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	115-118
8719789-4	1995	GR203040 potently inhibited [3H]-substance P binding to human NK1 receptors expressed in Chinese hamster ovary (CHO) and U373 MG astrocytoma cells, and NK1 receptors in ferret and gerbil cortex (pKi values of 10.3, 10.5, 10.1 and 10.1 respectively).	cho	112-115	tachykinin precursor 1	Homo sapiens	33-44
7592623-4	1995	FGF-2-dependent attachment of 32D-flg cells was prevented by inclusion of 10 micrograms/ml heparin in the incubation medium and was diminished when CHO mutants in glycosaminoglycan synthesis or wild-type CHO cells treated with heparinase were used, indicating that the attachment occurred through FGF-2 interactions with heparan sulfates on the CHO cells.	cho	148-151	fibroblast growth factor 2	Cricetulus griseus	0-5
7592623-4	1995	FGF-2-dependent attachment of 32D-flg cells was prevented by inclusion of 10 micrograms/ml heparin in the incubation medium and was diminished when CHO mutants in glycosaminoglycan synthesis or wild-type CHO cells treated with heparinase were used, indicating that the attachment occurred through FGF-2 interactions with heparan sulfates on the CHO cells.	cho	204-207	fibroblast growth factor 2	Cricetulus griseus	0-5
7592623-4	1995	FGF-2-dependent attachment of 32D-flg cells was prevented by inclusion of 10 micrograms/ml heparin in the incubation medium and was diminished when CHO mutants in glycosaminoglycan synthesis or wild-type CHO cells treated with heparinase were used, indicating that the attachment occurred through FGF-2 interactions with heparan sulfates on the CHO cells.	cho	204-207	fibroblast growth factor 2	Cricetulus griseus	0-5
7592623-8	1995	We conclude that attachment is due to FGF-2 binding simultaneously to receptors on the 32D-flg cells and heparan sulfates on the CHO monolayers; thus, the FGF-2 acts as a bridge between receptor-expressing cells and heparan sulfate-bearing cells.	cho	129-132	fibroblast growth factor 2	Cricetulus griseus	155-160
7592623-9	1995	In addition, induction of DNA synthesis in 32D-flg cells in response to FGF-2 was potentiated by the CHO-associated heparan sulfates to the same extent as by soluble heparin, indicating that this interaction has functional significance.	cho	101-104	fibroblast growth factor 2	Cricetulus griseus	72-77
7669585-4	1995	Histological examination of the site of injection of CHO clones transfected with hu-IL-8, hu-MIP-1 alpha or mu-MIP-1 alpha showed predominantly neutrophilic infiltration.	cho	53-56	chemokine (C-C motif) ligand 3	Mus musculus	111-122
7594823-2	1995	Chinese hamster ovary 10B2 (CHO) cells do not stain well with indo-1, so a CHO mutant cell line (CHO IS1) isolated in our laboratory with much-improved stainability for indo-1 was used to study CA++i changes in heated CHO cells.	cho	75-78	IS1	Homo sapiens	101-104
7481839-5	1995	In contrast, a CHO mutant deficient in deoxycytidine kinase, and thus unable to accumulate dFdCTP, maintained its CTP pools under identical conditions, suggesting that the CTP pool depletion was dependent on dFdC phosphorylation.	cho	15-18	deoxycytidine kinase	Cricetulus griseus	39-59
7638730-5	1995	Fluorescence-activated cell sorter analysis revealed 62% CHO cell surface expression of ICAM-1.	cho	57-60	intercellular adhesion molecule 1	Cricetulus griseus	88-94
7542655-2	1995	Purification of CHO-CFTR was achieved using a combination of alkali stripping, alpha-lysophosphatidylcholine extraction, DEAE ion-exchange, and immunoaffinity chromatography.	cho	16-19	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	20-24
7592670-3	1995	Equilibrium binding data with 125I-LPL revealed the presence of a class of high affinity binding sites with a KD of 7.8 nM in CHO cells, whereas no high affinity binding was observed for proteoglycan-deficient cells.	cho	126-129	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	35-38
7542655-6	1995	Both the purified CHO-CFTR and Sf9-CFTR when reconstituted into planar lipid bilayers exhibited a low pS, chloride-selective ion channel activity that was protein kinase A- and ATP-dependent.	cho	18-21	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	22-26
7542655-6	1995	Both the purified CHO-CFTR and Sf9-CFTR when reconstituted into planar lipid bilayers exhibited a low pS, chloride-selective ion channel activity that was protein kinase A- and ATP-dependent.	cho	18-21	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	35-39
7542655-7	1995	Both the purified CHO-CFTR and Sf9-CFTR were able to interact specifically with the nucleotide photoanalogue 8-N3-[alpha-32P]ATP with half-maximal binding at 25 and 50 microM, respectively.	cho	18-21	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	22-26
7542655-7	1995	Both the purified CHO-CFTR and Sf9-CFTR were able to interact specifically with the nucleotide photoanalogue 8-N3-[alpha-32P]ATP with half-maximal binding at 25 and 50 microM, respectively.	cho	18-21	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	35-39
8834000-4	1995	In agreement with this hypothesis, we find that the heterologous expression of human Kv1.3 resets the resting potential of CHO cells, setting it to the threshold of activation of Kv1.3.	cho	123-126	potassium voltage-gated channel subfamily A member 3	Homo sapiens	85-90
7588568-7	1995	Soluble uPAR, synthesized by CHO cells (corresponding to amino acids 1-277 of human uPAR), was isolated by ligand (uPA) affinity chromatography.	cho	29-32	urokinase plasminogen activator surface receptor	Cricetulus griseus	8-12
7588568-7	1995	Soluble uPAR, synthesized by CHO cells (corresponding to amino acids 1-277 of human uPAR), was isolated by ligand (uPA) affinity chromatography.	cho	29-32	plasminogen activator, urokinase	Homo sapiens	8-11
7605368-7	1995	Heparan sulfate-deficient CHO cells show a low capacity to bind and degrade LPL, about 10%-20% that of the wild type cells.	cho	26-29	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	76-79
7706300-12	1995	Furthermore, coexpression of beta-galactoside alpha 2,6-sialyltransferase with CD22 in the CHO cells abrogates sialic acid-dependent binding to cytokine-activated HEC.	cho	91-94	B-cell receptor CD22	Cricetulus griseus	79-83
7774670-5	1995	The Kd values of PACAP-27, PACAP-38, vasoactive intestinal peptide (VIP), PACAP-27 fragments and analogues evaluated by binding competition curves, were higher in CHO 2-10 than in CHO 4-12, whereas the Kd for PACAP-38 fragments did not differ.	cho	163-166	VIP peptides	Cricetulus griseus	37-66
7774670-5	1995	The Kd values of PACAP-27, PACAP-38, vasoactive intestinal peptide (VIP), PACAP-27 fragments and analogues evaluated by binding competition curves, were higher in CHO 2-10 than in CHO 4-12, whereas the Kd for PACAP-38 fragments did not differ.	cho	163-166	VIP peptides	Cricetulus griseus	68-71
7774670-5	1995	The Kd values of PACAP-27, PACAP-38, vasoactive intestinal peptide (VIP), PACAP-27 fragments and analogues evaluated by binding competition curves, were higher in CHO 2-10 than in CHO 4-12, whereas the Kd for PACAP-38 fragments did not differ.	cho	180-183	VIP peptides	Cricetulus griseus	37-66
7530251-5	1995	Unexpectedly, the association and degradation of 125I-labeled AcLDL by these CHO cells were not inhibited by dextran sulfate, fucoidan, and polyinosinic acid, competitors of macrophage scavenger receptors, but were completely inhibited by maleylated bovine serum albumin.	cho	77-80	albumin	Cricetulus griseus	257-270
7840143-7	1995	In CHO cells, the osmotically induced delta pHi was only weakly sensitive to amiloride, suggesting that osmotic forces may activate an H+ transport system other than Na+/H+ exchange.	cho	3-6	glucose-6-phosphate isomerase	Cricetulus griseus	44-47
7840143-8	1995	In the presence of 10 mM HCO3-, osmotically induced delta pHi decreased by 60% in VSM cells but increased by 50% in CHO cells compared with the delta pHi in HCO(3-)-free medium.	cho	116-119	glucose-6-phosphate isomerase	Cricetulus griseus	58-61
8717231-6	1995	The HPAEC profiles of oligosaccharides of these EPO products indicated that there were some differences in the carbohydrate moieties between CHO rh-EPO and BHK rh-EPO.	cho	141-144	erythropoietin	Cricetulus griseus	48-51
8717231-6	1995	The HPAEC profiles of oligosaccharides of these EPO products indicated that there were some differences in the carbohydrate moieties between CHO rh-EPO and BHK rh-EPO.	cho	141-144	erythropoietin	Cricetulus griseus	148-151
8717231-6	1995	The HPAEC profiles of oligosaccharides of these EPO products indicated that there were some differences in the carbohydrate moieties between CHO rh-EPO and BHK rh-EPO.	cho	141-144	erythropoietin	Cricetulus griseus	148-151
8834000-4	1995	In agreement with this hypothesis, we find that the heterologous expression of human Kv1.3 resets the resting potential of CHO cells, setting it to the threshold of activation of Kv1.3.	cho	123-126	potassium channel, voltage gated shaker related subfamily A, member 3 S homeolog	Xenopus laevis	179-184
7991602-3	1994	CHO mutant cells lacking heparan sulfate proteoglycans (HSPG) bind EGF equally well to wild-type cells and EGF binding is not affected by exogenous heparin.	cho	0-3	LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein	Cricetulus griseus	56-60
7991602-3	1994	CHO mutant cells lacking heparan sulfate proteoglycans (HSPG) bind EGF equally well to wild-type cells and EGF binding is not affected by exogenous heparin.	cho	0-3	LOW QUALITY PROTEIN: pro-epidermal growth factor	Cricetulus griseus	67-70
7526899-5	1994	In mutant CHO cells (pgsD-677) lacking HSPG, the level of 125I-lactoferrin binding was approximately 50% that seen with wild-type CHO cells; thus, about one half of lactoferrin binding appears to be mediated through cell-surface HSPG.	cho	10-13	LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein	Cricetulus griseus	39-43
7982995-4	1994	In both NMuMG and CHO cells expressing wild-type PDGF beta-receptors, PDGF B/B activated the amiloride-sensitive Na+/H+ exchanger.	cho	18-21	LOW QUALITY PROTEIN: platelet-derived growth factor subunit B	Cricetulus griseus	49-58
7982995-4	1994	In both NMuMG and CHO cells expressing wild-type PDGF beta-receptors, PDGF B/B activated the amiloride-sensitive Na+/H+ exchanger.	cho	18-21	LOW QUALITY PROTEIN: platelet-derived growth factor subunit B	Cricetulus griseus	70-76
7875042-7	1994	Loading of a second calcium fluorescent probe fluo-3AM was improved in CHO cells by P-gp inhibition, whereas the structurally related pH probe BCECF-AM was minimally affected.	cho	71-74	phosphoglycolate phosphatase	Homo sapiens	84-88
11725000-5	1994	Similar phenomena were also observed, in that insulin regulated pRSVLTR-betagal and pMLSV(2)HBsAg in these three CHO lines.	cho	113-116	insulin	Cricetulus griseus	46-53
7530460-11	1994	Under optimum conditions, penetration of large quantities of FITC-dextran (70 kDa) and beta-galactosidase into 90%-95% of CHO cells while preserving their viability has been observed.	cho	122-125	beta-galactosidase	Cricetulus griseus	87-105
7521361-5	1994	We have expressed human rCD58 and rCD59 molecules in Chinese hamster oocytes (CHO), and tested paraformaldehyde-treated transfectants for the ability to promote proliferation of and IL-2 secretion from PBMC and human purified T cells.	cho	78-81	CD59 molecule	Rattus norvegicus	34-39
7521363-9	1994	Reverse transcriptase-PCR analysis of Jurkat cells stimulated with staphylococcal enterotoxin E and the different CHO transfectants revealed that the cooperative effect of B7 and LFA-3 on IL-2 production was also seen at the mRNA level.	cho	114-117	CD58 molecule	Homo sapiens	179-184
7521363-9	1994	Reverse transcriptase-PCR analysis of Jurkat cells stimulated with staphylococcal enterotoxin E and the different CHO transfectants revealed that the cooperative effect of B7 and LFA-3 on IL-2 production was also seen at the mRNA level.	cho	114-117	interleukin 2	Homo sapiens	188-192
8063815-7	1994	In CHO cells expressing mutated GHR, GH-dependent tyrosyl phosphorylation of cellular proteins (p121, p97, p42, and p39) was dependent on the ability to activate JAK2.	cho	3-6	growth hormone receptor	Cricetulus griseus	32-35
8063815-7	1994	In CHO cells expressing mutated GHR, GH-dependent tyrosyl phosphorylation of cellular proteins (p121, p97, p42, and p39) was dependent on the ability to activate JAK2.	cho	3-6	tyrosine-protein kinase JAK2	Cricetulus griseus	162-166
8079344-4	1994	Exposure of wild-type (CHO/WT) or CHO/AADC cultures to L-dopa (62 to 500 microM) resulted in intracellular accumulation of L-dopa or L-dopa and dopamine, respectively, that was concentration-dependent.	cho	34-37	dopa decarboxylase	Bos taurus	38-42
8074647-4	1994	VIP induced increases in intracellular cAMP levels ([cAMP]i) dose-dependently with an EC50 of 0.2 nM in 293 and CHO stable transfectants and concurrently evoked dose-dependent increases in intracellular calcium concentrations ([Ca2+]i), as determined by fluorescence-dye spectroscopy.	cho	112-115	vasoactive intestinal peptide	Homo sapiens	0-3
7530070-5	1994	The two major glycoforms determined using this methodology correspond to those determined previously for CHO-produced G-CSF using NMR.	cho	105-108	granulocyte colony-stimulating factor	Cricetulus griseus	118-123
8135848-4	1994	In CHO/ETB cells, the ET-1 response was mimicked by 4AlaET-1 which could be blocked partially by PD 145065, a nonselective antagonist of ETA and ETB.	cho	3-6	endothelin receptor type B	Homo sapiens	7-10
8007958-8	1994	In this study, we show that eIF-2B activity was inhibited in parental CHO cell extracts upon addition of purified reticulocyte heme-regulated inhibitor (HRI), an eIF-2 alpha kinase that phosphorylates Ser-51.	cho	70-73	eukaryotic translation initiation factor 2A	Cricetulus griseus	162-173
7950365-4	1994	The highest expressing CHO cell line contained 1400-6000 units of alpha-L-iduronidase per milligram of protein, or 0.6-2.4% of total cell protein.	cho	23-26	alpha-L-iduronidase	Cricetulus griseus	66-85
8156904-7	1994	Stimulation of the CHO-TSHR cells with TSH did not result in a desensitization toward a second TSH stimulation, nor did it reduce the binding of [125I]TSH.	cho	19-22	thyroid stimulating hormone receptor	Homo sapiens	23-27
8035823-2	1994	The CHO PAF-1 comprised 304 amino acids, one residue shorter than rat or human PAF-1, and showed high homology to rat and human PAF-1: 90 and 86% at the nucleotide sequence level and 92 and 90% in amino acid sequence, respectively.	cho	4-7	PAF1 homolog, Paf1/RNA polymerase II complex component	Rattus norvegicus	8-13
8185634-5	1994	MoAbs to N-domain of CEA markedly inhibited the liver metastasis of CHO/CEA cells, while a MoAb to domain III of the antigen did not.	cho	68-71	carcinoembryonic antigen gene family	Mus musculus	21-24
8185634-5	1994	MoAbs to N-domain of CEA markedly inhibited the liver metastasis of CHO/CEA cells, while a MoAb to domain III of the antigen did not.	cho	68-71	carcinoembryonic antigen gene family	Mus musculus	72-75
8135848-4	1994	In CHO/ETB cells, the ET-1 response was mimicked by 4AlaET-1 which could be blocked partially by PD 145065, a nonselective antagonist of ETA and ETB.	cho	3-6	endothelin-1	Cricetulus griseus	22-26
8135848-4	1994	In CHO/ETB cells, the ET-1 response was mimicked by 4AlaET-1 which could be blocked partially by PD 145065, a nonselective antagonist of ETA and ETB.	cho	3-6	endothelin receptor type A	Homo sapiens	137-140
8135848-4	1994	In CHO/ETB cells, the ET-1 response was mimicked by 4AlaET-1 which could be blocked partially by PD 145065, a nonselective antagonist of ETA and ETB.	cho	3-6	endothelin receptor type B	Homo sapiens	145-148
8131857-6	1994	A similar effect of vanadate on MAP kinase tyrosyl phosphorylation and activation was also observed in CHO cells over-expressing a protein tyrosine kinase-deficient insulin receptor (CHO-1018).	cho	103-106	insulin receptor	Cricetulus griseus	165-181
7508445-5	1994	A CHO cell line overexpressing the mutant insulin receptor, substituting Ala960 for Tyr960 and which was known to exhibit impaired tyrosine phosphorylation of IRS-1 and biological effects evoked by insulin, showed severely impaired insulin-dependent tyrosine phosphorylation of Shc and moderately impaired activation of Ras.	cho	2-5	insulin receptor	Cricetulus griseus	42-58
7508445-5	1994	A CHO cell line overexpressing the mutant insulin receptor, substituting Ala960 for Tyr960 and which was known to exhibit impaired tyrosine phosphorylation of IRS-1 and biological effects evoked by insulin, showed severely impaired insulin-dependent tyrosine phosphorylation of Shc and moderately impaired activation of Ras.	cho	2-5	insulin receptor substrate 1	Cricetulus griseus	159-164
7508445-5	1994	A CHO cell line overexpressing the mutant insulin receptor, substituting Ala960 for Tyr960 and which was known to exhibit impaired tyrosine phosphorylation of IRS-1 and biological effects evoked by insulin, showed severely impaired insulin-dependent tyrosine phosphorylation of Shc and moderately impaired activation of Ras.	cho	2-5	insulin	Cricetulus griseus	42-49
7508445-5	1994	A CHO cell line overexpressing the mutant insulin receptor, substituting Ala960 for Tyr960 and which was known to exhibit impaired tyrosine phosphorylation of IRS-1 and biological effects evoked by insulin, showed severely impaired insulin-dependent tyrosine phosphorylation of Shc and moderately impaired activation of Ras.	cho	2-5	insulin	Cricetulus griseus	198-205
8305414-3	1994	CHO-LPL constitutively produced a high level of LPL, whereas CHO-anti-LPL produced a minimal level.	cho	0-3	lipoprotein lipase	Homo sapiens	4-7
8305414-3	1994	CHO-LPL constitutively produced a high level of LPL, whereas CHO-anti-LPL produced a minimal level.	cho	0-3	lipoprotein lipase	Homo sapiens	48-51
8305414-5	1994	CHO-LPL took up and degraded 125I-VLDL at 37 degrees C four times more strongly than did CHO-anti-LPL.	cho	0-3	lipoprotein lipase	Homo sapiens	4-7
8305414-7	1994	Furthermore, we found that binding at 4 degrees C of VLDL and LDL to CHO-LPL was greater than to CHO-anti-LPL, and this binding difference was abolished by washing the cells with heparin.	cho	69-72	lipoprotein lipase	Homo sapiens	73-76
8011427-1	1994	We previously reported that Chinese hamster ovary (CHO) cell lines overexpressing mutated human insulin receptors (hIRs) in which the tyrosine residues 1162 and 1163 were replaced by phenylalanines (CHO-Y2) exhibited a marked defect in hormone-induced receptor internalization as compared to CHO transfectants overexpressing wild-type hIRs (CHO-R).	cho	51-54	insulin	Cricetulus griseus	96-103
8299584-8	1994	Squirrel monkey CBG is produced by CHO cells as a dimer, and its subunit size heterogeneity is similar to that associated with CBG in serum.	cho	35-38	serpin family A member 6	Homo sapiens	16-19
8299584-9	1994	In addition, the cortisol-binding affinity of squirrel monkey CBG produced by CHO cells is similar to that of the natural protein and is 5- to 8-fold lower than that of natural or recombinant human CBG.	cho	78-81	serpin family A member 6	Homo sapiens	62-65
8299584-10	1994	Mutants in which a threonine at position 144 was either added to human CBG or subtracted from squirrel monkey CBG were also expressed in CHO cells.	cho	137-140	serpin family A member 6	Homo sapiens	110-113
8299716-7	1994	Heat-shocked CHO cells also accumulated transiently high levels of J6 mRNA between 2 and 7 h following 10 min at 45 degrees C. These induction kinetics are similar to those for GP50 labeling with D-[3H]mannose and to the activation of major heat shock genes, e.g., hsp70.	cho	13-16	serpin H1	Cricetulus griseus	177-181
8011427-1	1994	We previously reported that Chinese hamster ovary (CHO) cell lines overexpressing mutated human insulin receptors (hIRs) in which the tyrosine residues 1162 and 1163 were replaced by phenylalanines (CHO-Y2) exhibited a marked defect in hormone-induced receptor internalization as compared to CHO transfectants overexpressing wild-type hIRs (CHO-R).	cho	199-202	insulin	Cricetulus griseus	96-103
8253769-4	1993	The mechanism of ACE release in CHO cells involves a post-translational proteolytic cleavage occurring in the carboxyl-terminal region.	cho	32-35	angiotensin-converting enzyme	Cricetulus griseus	17-20
7504269-7	1993	Affinity chromatography of 125I-labeled CHO cell membrane proteins, using IGFBP-1 coupled to agarose, identified the alpha 5 beta 1 integrin (fibronectin receptor) as the only cell surface molecule capable of binding IGFBP-1 in an RGD-dependent manner.	cho	40-43	insulin-like growth factor-binding protein 1	Cricetulus griseus	74-81
7504269-9	1993	These studies demonstrate that IGFBP-1 stimulates CHO cell migration and binds to the alpha 5 beta 1 integrin receptor, both by an RGD-dependent mechanism.	cho	50-53	insulin-like growth factor-binding protein 1	Cricetulus griseus	31-38
8400241-7	1993	When expressed in wild-type CHO cells and analyzed on Western blots, each of the four mutants had a faster electrophoretic mobility than wild-type glycophorin A, corresponding to a difference of approximately 4 Kd.	cho	28-31	glycophorin A (MNS blood group)	Homo sapiens	147-160
8216232-5	1993	Thus the main pathway for ODC degradation in a reticulocyte lysate was essentially the same as that characterized previously in extracts of HTC and CHO cells, namely an ATP- and antizyme-dependent 26 S proteasome-catalysed pathway that is presumed to be responsible for ODC degradation in whole cells.	cho	148-151	ornithine decarboxylase 1	Rattus norvegicus	26-29
8364905-4	1993	In addition, CHO-IL10 cells suppressed the growth of equal numbers of coinjected but not of contralaterally injected CHO cells.	cho	13-16	interleukin-10	Cricetulus griseus	17-21
8333551-4	1993	Acute survival during paraquat exposure (0-500 microM) was significantly improved in CHO cells expressing human Mn SOD, with 71% of recombinant CHO cells surviving at the 50% lethal dose (LD50) for wild-type CHO controls.	cho	85-88	superoxide dismutase 2	Homo sapiens	112-118
7763906-11	1993	These observations seemed to indicate that the interaction between serum factors and cell surface, i.e., AeS, is an important parameter of the growth of CHO cells.	cho	153-156	TLE family member 5	Cricetulus griseus	105-108
7686165-5	1993	In CHO cells, on the other hand, overexpression of either IGF-I or insulin receptors increased the sensitivity of thymidine incorporation to ligand, but maximal responsiveness was unchanged or decreased.	cho	3-6	insulin-like growth factor I	Cricetulus griseus	58-63
7686165-5	1993	In CHO cells, on the other hand, overexpression of either IGF-I or insulin receptors increased the sensitivity of thymidine incorporation to ligand, but maximal responsiveness was unchanged or decreased.	cho	3-6	insulin	Cricetulus griseus	67-74
8099750-5	1993	Significant increases in the Cho/Cr ratios were seen in patients with low CD4 lymphocyte counts and abnormal magnetic resonance (MR) images.	cho	29-32	CD4 molecule	Homo sapiens	74-77
8349705-5	1993	Both CCK-8 and gastrin I markedly augmented phosphoinositide hydrolysis and cytosolic free calcium levels in the CHO transfectants, indicating that the cloned CCK-B receptor could functionally couple with intracellular signaling molecules.	cho	113-116	cholecystokinin	Homo sapiens	5-8
8349705-5	1993	Both CCK-8 and gastrin I markedly augmented phosphoinositide hydrolysis and cytosolic free calcium levels in the CHO transfectants, indicating that the cloned CCK-B receptor could functionally couple with intracellular signaling molecules.	cho	113-116	gastrin	Homo sapiens	15-22
8349705-5	1993	Both CCK-8 and gastrin I markedly augmented phosphoinositide hydrolysis and cytosolic free calcium levels in the CHO transfectants, indicating that the cloned CCK-B receptor could functionally couple with intracellular signaling molecules.	cho	113-116	cholecystokinin B receptor	Homo sapiens	159-173
8349705-6	1993	Moreover, CCK-8 and gastrin I dose-dependently increased [3H]thymidine incorporation of the CHO transfectants in serum-free medium and promoted cell growth.	cho	92-95	cholecystokinin	Homo sapiens	10-13
8349705-6	1993	Moreover, CCK-8 and gastrin I dose-dependently increased [3H]thymidine incorporation of the CHO transfectants in serum-free medium and promoted cell growth.	cho	92-95	gastrin	Homo sapiens	20-27
8506307-10	1993	These results demonstrate that the ability of CHO cells to modify glutamic acid residues to gamma-carboxyglutamic acid in secreted factor IX is not limited by the expression of the vitamin K-dependent gamma-carboxylase alone.	cho	46-49	vitamin K-dependent gamma-carboxylase	Cricetulus griseus	181-218
21573527-2	1993	In this study, we examine the effect of MIS-transfection on the growth characteristics of Chinese hamster ovary (CHO) and human ocular melanoma (OM431) cells, compared to wild-type lines and a CHO line transfected with a noncleavable, inactive MIS mutant.	cho	113-116	anti-Mullerian hormone	Homo sapiens	40-43
7682233-7	1993	Cell-surface expression of CD28, but not CD2 or CD3, decreased by 12 to 24 h after addition of B7+ CHO cells, but returned to initial levels or higher by 48 h. The ability of CD28 cross-linking on PMA-activated CD4+ cells to trigger calcium mobilization was also reduced by treatment with B7+ CHO cells, and remained reduced even after cell-surface expression of CD28 returned to normal levels.	cho	99-102	T-cell-specific surface glycoprotein CD28	Cricetulus griseus	27-31
7682233-7	1993	Cell-surface expression of CD28, but not CD2 or CD3, decreased by 12 to 24 h after addition of B7+ CHO cells, but returned to initial levels or higher by 48 h. The ability of CD28 cross-linking on PMA-activated CD4+ cells to trigger calcium mobilization was also reduced by treatment with B7+ CHO cells, and remained reduced even after cell-surface expression of CD28 returned to normal levels.	cho	99-102	T-cell surface antigen CD2	Cricetulus griseus	27-30
7682233-7	1993	Cell-surface expression of CD28, but not CD2 or CD3, decreased by 12 to 24 h after addition of B7+ CHO cells, but returned to initial levels or higher by 48 h. The ability of CD28 cross-linking on PMA-activated CD4+ cells to trigger calcium mobilization was also reduced by treatment with B7+ CHO cells, and remained reduced even after cell-surface expression of CD28 returned to normal levels.	cho	99-102	T-cell-specific surface glycoprotein CD28	Cricetulus griseus	175-179
7682233-7	1993	Cell-surface expression of CD28, but not CD2 or CD3, decreased by 12 to 24 h after addition of B7+ CHO cells, but returned to initial levels or higher by 48 h. The ability of CD28 cross-linking on PMA-activated CD4+ cells to trigger calcium mobilization was also reduced by treatment with B7+ CHO cells, and remained reduced even after cell-surface expression of CD28 returned to normal levels.	cho	99-102	T-cell-specific surface glycoprotein CD28	Cricetulus griseus	175-179
7682233-7	1993	Cell-surface expression of CD28, but not CD2 or CD3, decreased by 12 to 24 h after addition of B7+ CHO cells, but returned to initial levels or higher by 48 h. The ability of CD28 cross-linking on PMA-activated CD4+ cells to trigger calcium mobilization was also reduced by treatment with B7+ CHO cells, and remained reduced even after cell-surface expression of CD28 returned to normal levels.	cho	293-296	T-cell-specific surface glycoprotein CD28	Cricetulus griseus	27-31
7682233-7	1993	Cell-surface expression of CD28, but not CD2 or CD3, decreased by 12 to 24 h after addition of B7+ CHO cells, but returned to initial levels or higher by 48 h. The ability of CD28 cross-linking on PMA-activated CD4+ cells to trigger calcium mobilization was also reduced by treatment with B7+ CHO cells, and remained reduced even after cell-surface expression of CD28 returned to normal levels.	cho	293-296	T-cell surface antigen CD2	Cricetulus griseus	27-30
7682233-7	1993	Cell-surface expression of CD28, but not CD2 or CD3, decreased by 12 to 24 h after addition of B7+ CHO cells, but returned to initial levels or higher by 48 h. The ability of CD28 cross-linking on PMA-activated CD4+ cells to trigger calcium mobilization was also reduced by treatment with B7+ CHO cells, and remained reduced even after cell-surface expression of CD28 returned to normal levels.	cho	293-296	T-cell-specific surface glycoprotein CD28	Cricetulus griseus	175-179
7682233-7	1993	Cell-surface expression of CD28, but not CD2 or CD3, decreased by 12 to 24 h after addition of B7+ CHO cells, but returned to initial levels or higher by 48 h. The ability of CD28 cross-linking on PMA-activated CD4+ cells to trigger calcium mobilization was also reduced by treatment with B7+ CHO cells, and remained reduced even after cell-surface expression of CD28 returned to normal levels.	cho	293-296	T-cell surface glycoprotein CD4	Cricetulus griseus	211-214
7682233-7	1993	Cell-surface expression of CD28, but not CD2 or CD3, decreased by 12 to 24 h after addition of B7+ CHO cells, but returned to initial levels or higher by 48 h. The ability of CD28 cross-linking on PMA-activated CD4+ cells to trigger calcium mobilization was also reduced by treatment with B7+ CHO cells, and remained reduced even after cell-surface expression of CD28 returned to normal levels.	cho	293-296	T-cell-specific surface glycoprotein CD28	Cricetulus griseus	175-179
8436180-8	1993	In CHO cells, labeling by GTPoxi took place only when CD3-gamma was associated with CD3-epsilon, whereas labeling could not be established upon association of CD3-gamma with CD3-delta or TcR alpha.	cho	3-6	CD3 gamma subunit of T-cell receptor complex	Homo sapiens	54-63
8379190-5	1993	The GLUT2 content in the plasma membrane fraction of insulin-treated CHO cells expressing GLUT2 increased 3.8-fold compared to that of the control group.	cho	69-72	insulin	Cricetulus griseus	53-60
21573527-3	1993	MIS-transfection inhibited proliferation of CHO cells in double-layer agarose, tumor spheroid, and murine subrenal capsule assays, as well as growth of CHO and OM431 cells in pulmonary metastasis studies.	cho	44-47	anti-Mullerian hormone	Homo sapiens	0-3
1461145-1	1992	It is commonly believed that high-carbohydrate (CHO) diets improve peripheral insulin sensitivity; however, this concept is based on anecdotal evidence.	cho	48-51	insulin	Homo sapiens	78-85
1461145-2	1992	Furthermore, it has been demonstrated that in non-insulin-dependent diabetic patients treated with insulin, a high-monounsaturated-fat (MUFA) diet is more effective than a high-complex-CHO diet in reducing blood glucose levels.	cho	185-188	insulin	Homo sapiens	99-106
1461145-3	1992	The aim of our study was to compare the effect of a high-MUFA diet and a high-CHO diet on peripheral insulin sensitivity and metabolic control in non-insulin-dependent diabetic patients.	cho	78-81	insulin	Homo sapiens	101-108
1711565-4	1991	A cDNA construct encoding a transmembrane version of DAF (DAF-TM) protects CHO transfectants from cytotoxicity with equal efficiency to DAF.	cho	75-78	CD55 molecule (Cromer blood group)	Homo sapiens	53-56
8429264-1	1993	The ability of lipid-free human apoA-I expressed by transfected Chinese hamster ovary (CHO) cells to form apoA-I-lipid complexes extracellularly when incubated with CHO cell monolayers was investigated.	cho	87-90	apolipoprotein A1	Homo sapiens	32-38
8429264-1	1993	The ability of lipid-free human apoA-I expressed by transfected Chinese hamster ovary (CHO) cells to form apoA-I-lipid complexes extracellularly when incubated with CHO cell monolayers was investigated.	cho	87-90	apolipoprotein A1	Homo sapiens	106-112
1400872-6	1992	The product was secreted normally but proportionally less of it (54%) bound to concanavalin A when compared to normal SHBG produced by CHO cells (85%), or SHBG in the serum of either a normal individual or those who produce an electrophoretic variant (98%).	cho	135-138	sex hormone-binding globulin	Cricetulus griseus	118-122
1724918-3	1991	Two new CHO mutants possessing alpha(1,3)Fuc-T activity (LEC29 and LEC30) have now been isolated after treatment of a CHO cell population with 5-azacytidine (5-AzaC), ethylnitrosourea (ENU), or 5-AzaC followed by N-methyl-N"-nitro-N-nitrosoguanidine (MNNG).	cho	8-11	adrenoceptor alpha 1D	Homo sapiens	31-40
1718983-10	1991	In addition, they both caused CHO transfectants to synthesize the Lex determinant Gal beta(1,4)[Fuc alpha(1,3)]GlcNAc beta 1 but not the alpha(2,3)-sialyl-Lex determinant.	cho	30-33	fucosyltransferase 4	Homo sapiens	66-69
1718983-10	1991	In addition, they both caused CHO transfectants to synthesize the Lex determinant Gal beta(1,4)[Fuc alpha(1,3)]GlcNAc beta 1 but not the alpha(2,3)-sialyl-Lex determinant.	cho	30-33	fucosyltransferase 4	Homo sapiens	155-158
1918997-6	1991	The stimulatory capacity of both natural and full-length CHO cell-derived gp120 was eliminated by heating at 100 degrees C, and could be blocked with excess CHO cell-derived gp120 fusion protein.	cho	57-60	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	74-79
1918997-6	1991	The stimulatory capacity of both natural and full-length CHO cell-derived gp120 was eliminated by heating at 100 degrees C, and could be blocked with excess CHO cell-derived gp120 fusion protein.	cho	57-60	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	174-179
1723489-5	1991	In addition, when SHBG produced by CHO cells was separated into two fractions by Con-A chromatography and analyzed by polyacrylamide gel electrophoresis, SHBG that did not interact with Con-A migrated with a slightly larger apparent mol wt than that of SHBG that binds Con-A; this can be explained by the presence of triantennary, rather than biantennary, N-linked oligosaccharide chains.	cho	35-38	sex hormone-binding globulin	Cricetulus griseus	18-22
1723489-5	1991	In addition, when SHBG produced by CHO cells was separated into two fractions by Con-A chromatography and analyzed by polyacrylamide gel electrophoresis, SHBG that did not interact with Con-A migrated with a slightly larger apparent mol wt than that of SHBG that binds Con-A; this can be explained by the presence of triantennary, rather than biantennary, N-linked oligosaccharide chains.	cho	35-38	sex hormone-binding globulin	Cricetulus griseus	154-158
1723489-5	1991	In addition, when SHBG produced by CHO cells was separated into two fractions by Con-A chromatography and analyzed by polyacrylamide gel electrophoresis, SHBG that did not interact with Con-A migrated with a slightly larger apparent mol wt than that of SHBG that binds Con-A; this can be explained by the presence of triantennary, rather than biantennary, N-linked oligosaccharide chains.	cho	35-38	sex hormone-binding globulin	Cricetulus griseus	154-158
1915369-9	1991	Mutant CHO cells, deficient in peroxisomes, lack nsLTP.	cho	7-10	sterol carrier protein 2	Rattus norvegicus	49-54
1742081-4	1991	Cytotoxicity of sCD4-PE40 for CHO-env in the presence or absence of added human serum was quantitated spectrophometrically following enzymatic reduction of a tetrazolium bromide within the mitochondria of viable cells (MTT assay).	cho	30-33	stearoyl-CoA desaturase 5	Homo sapiens	16-20
1742081-4	1991	Cytotoxicity of sCD4-PE40 for CHO-env in the presence or absence of added human serum was quantitated spectrophometrically following enzymatic reduction of a tetrazolium bromide within the mitochondria of viable cells (MTT assay).	cho	30-33	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	34-37
1385518-6	1992	The response of CD4-8+T3.70+ cells to T3.70/B7+CHO or to male DC stimulation were inhibited by CTLA4Ig, a fusion protein comprising the extracellular portion of CTLA4 and human IgG C gamma 1.	cho	47-50	cytotoxic T-lymphocyte protein 4	Cricetulus griseus	95-100
1429568-4	1992	The internalization of bFGF through the heparin-resistant pathway in CHO cells was efficiently competed by addition of unlabeled bFGF, was proportional to the number of receptors expressed, and approached saturation, suggesting that the heparin-resistant internalization was due to high affinity receptors.	cho	69-72	fibroblast growth factor 2	Bos taurus	23-27
1429568-4	1992	The internalization of bFGF through the heparin-resistant pathway in CHO cells was efficiently competed by addition of unlabeled bFGF, was proportional to the number of receptors expressed, and approached saturation, suggesting that the heparin-resistant internalization was due to high affinity receptors.	cho	69-72	fibroblast growth factor 2	Bos taurus	129-133
1429568-7	1992	Internalization of bFGF in the parental CHO cells was inhibited at the same concentrations of heparin that block binding to cell-surface heparan sulfates.	cho	40-43	fibroblast growth factor 2	Bos taurus	19-23
1429568-8	1992	Finally, inhibition of the sulfation of CHO cell heparan sulfates by the addition of chlorate or digestion of CHO cell heparan sulfates with heparinase inhibited bFGF internalization in the parental CHO cells.	cho	40-43	fibroblast growth factor 2	Bos taurus	162-166
1618780-6	1992	When CHO cells transfected with F/Y CT2 (CHO-F/Y CT2) were stimulated with insulin, autophosphorylation of the beta-subunit of the insulin receptor and the phosphorylation of an endogenous substrate (pp185) in the intact cell were normal compared with cells expressing HIR (CHO-HIR).	cho	5-8	insulin	Cricetulus griseus	75-82
1618780-6	1992	When CHO cells transfected with F/Y CT2 (CHO-F/Y CT2) were stimulated with insulin, autophosphorylation of the beta-subunit of the insulin receptor and the phosphorylation of an endogenous substrate (pp185) in the intact cell were normal compared with cells expressing HIR (CHO-HIR).	cho	5-8	insulin	Cricetulus griseus	131-138
1627362-6	1992	This was done by cotransfecting plasmids pZIPNeo and pSV2dhfr into DHFR-CHO cells followed by isolation of a Neo + DHFR + CHO donor colony and radiation-fusion-hybridization (RFH) to EMT-6 cells.	cho	72-75	dihydrofolate reductase	Homo sapiens	67-71
1367984-0	1992	A CHO strain producing high-level human IL-6 with the 3" deletion construct.	cho	2-5	interleukin 6	Homo sapiens	40-44
1370512-5	1992	3) Double transfected CD58+CD59+ CHO cells formed up to 80% of rosettes, largely exceeding the sum of rosettes formed by single transfectants, thus disclosing at least an additive and possibly a synergic action of both molecules in mediating adhesion to T cells.	cho	33-36	CD59 glycoprotein	Cricetulus griseus	27-31
1370512-6	1992	Culturing purified human T cells in the presence of fixed CHO transfectants and submitogenic doses of PHA + rIL-1 alpha showed that: 1) CD59+ CHO transfectants induced sevenfold T cell proliferation enhancement, demonstrating the direct involvement of the CD59 molecule in T cell activation; 2) CD58+ CHO transfectants induced 20-fold T cell proliferation increase; and 3) the enhancement induced by CD58+CD59+ CHO cells was more than 40-fold.	cho	58-61	CD59 molecule (CD59 blood group)	Homo sapiens	136-140
1370512-6	1992	Culturing purified human T cells in the presence of fixed CHO transfectants and submitogenic doses of PHA + rIL-1 alpha showed that: 1) CD59+ CHO transfectants induced sevenfold T cell proliferation enhancement, demonstrating the direct involvement of the CD59 molecule in T cell activation; 2) CD58+ CHO transfectants induced 20-fold T cell proliferation increase; and 3) the enhancement induced by CD58+CD59+ CHO cells was more than 40-fold.	cho	142-145	interleukin 1 alpha	Rattus norvegicus	108-119
1370512-6	1992	Culturing purified human T cells in the presence of fixed CHO transfectants and submitogenic doses of PHA + rIL-1 alpha showed that: 1) CD59+ CHO transfectants induced sevenfold T cell proliferation enhancement, demonstrating the direct involvement of the CD59 molecule in T cell activation; 2) CD58+ CHO transfectants induced 20-fold T cell proliferation increase; and 3) the enhancement induced by CD58+CD59+ CHO cells was more than 40-fold.	cho	142-145	CD59 glycoprotein	Cricetulus griseus	256-260
1370512-6	1992	Culturing purified human T cells in the presence of fixed CHO transfectants and submitogenic doses of PHA + rIL-1 alpha showed that: 1) CD59+ CHO transfectants induced sevenfold T cell proliferation enhancement, demonstrating the direct involvement of the CD59 molecule in T cell activation; 2) CD58+ CHO transfectants induced 20-fold T cell proliferation increase; and 3) the enhancement induced by CD58+CD59+ CHO cells was more than 40-fold.	cho	142-145	CD59 molecule (CD59 blood group)	Homo sapiens	256-260
1370512-6	1992	Culturing purified human T cells in the presence of fixed CHO transfectants and submitogenic doses of PHA + rIL-1 alpha showed that: 1) CD59+ CHO transfectants induced sevenfold T cell proliferation enhancement, demonstrating the direct involvement of the CD59 molecule in T cell activation; 2) CD58+ CHO transfectants induced 20-fold T cell proliferation increase; and 3) the enhancement induced by CD58+CD59+ CHO cells was more than 40-fold.	cho	142-145	interleukin 1 alpha	Rattus norvegicus	108-119
1370512-6	1992	Culturing purified human T cells in the presence of fixed CHO transfectants and submitogenic doses of PHA + rIL-1 alpha showed that: 1) CD59+ CHO transfectants induced sevenfold T cell proliferation enhancement, demonstrating the direct involvement of the CD59 molecule in T cell activation; 2) CD58+ CHO transfectants induced 20-fold T cell proliferation increase; and 3) the enhancement induced by CD58+CD59+ CHO cells was more than 40-fold.	cho	142-145	CD59 glycoprotein	Cricetulus griseus	256-260
1370512-6	1992	Culturing purified human T cells in the presence of fixed CHO transfectants and submitogenic doses of PHA + rIL-1 alpha showed that: 1) CD59+ CHO transfectants induced sevenfold T cell proliferation enhancement, demonstrating the direct involvement of the CD59 molecule in T cell activation; 2) CD58+ CHO transfectants induced 20-fold T cell proliferation increase; and 3) the enhancement induced by CD58+CD59+ CHO cells was more than 40-fold.	cho	142-145	CD59 molecule (CD59 blood group)	Homo sapiens	256-260
1370512-6	1992	Culturing purified human T cells in the presence of fixed CHO transfectants and submitogenic doses of PHA + rIL-1 alpha showed that: 1) CD59+ CHO transfectants induced sevenfold T cell proliferation enhancement, demonstrating the direct involvement of the CD59 molecule in T cell activation; 2) CD58+ CHO transfectants induced 20-fold T cell proliferation increase; and 3) the enhancement induced by CD58+CD59+ CHO cells was more than 40-fold.	cho	142-145	interleukin 1 alpha	Rattus norvegicus	108-119
1370512-6	1992	Culturing purified human T cells in the presence of fixed CHO transfectants and submitogenic doses of PHA + rIL-1 alpha showed that: 1) CD59+ CHO transfectants induced sevenfold T cell proliferation enhancement, demonstrating the direct involvement of the CD59 molecule in T cell activation; 2) CD58+ CHO transfectants induced 20-fold T cell proliferation increase; and 3) the enhancement induced by CD58+CD59+ CHO cells was more than 40-fold.	cho	142-145	CD59 glycoprotein	Cricetulus griseus	256-260
1370512-6	1992	Culturing purified human T cells in the presence of fixed CHO transfectants and submitogenic doses of PHA + rIL-1 alpha showed that: 1) CD59+ CHO transfectants induced sevenfold T cell proliferation enhancement, demonstrating the direct involvement of the CD59 molecule in T cell activation; 2) CD58+ CHO transfectants induced 20-fold T cell proliferation increase; and 3) the enhancement induced by CD58+CD59+ CHO cells was more than 40-fold.	cho	142-145	CD59 molecule (CD59 blood group)	Homo sapiens	256-260
1615470-5	1992	By SDS-agarose gel electrophoresis, the percentage of high molecular weight forms of vWF varied from 39 to 49% relative to normal plasma for BHK, CHO, 143B and chicken cells but was less than 10% for L cells.	cho	146-149	von Willebrand factor	Mesocricetus auratus	85-88
1615470-8	1992	By SDS-PAGE of reduced samples, pro-vWF was present in similar quantity to the fully processed vWF subunit in L cells, present in moderate amounts in BHK and CHO and in very low amounts in 143B and chicken cells.	cho	158-161	von Willebrand factor	Homo sapiens	36-39
1711565-4	1991	A cDNA construct encoding a transmembrane version of DAF (DAF-TM) protects CHO transfectants from cytotoxicity with equal efficiency to DAF.	cho	75-78	CD55 molecule (Cromer blood group)	Homo sapiens	58-64
1711565-4	1991	A cDNA construct encoding a transmembrane version of DAF (DAF-TM) protects CHO transfectants from cytotoxicity with equal efficiency to DAF.	cho	75-78	CD55 molecule (Cromer blood group)	Homo sapiens	58-61
1645354-6	1991	In the intact CHO cells, insulin-stimulated serine and threonine phosphorylation of the IR delta ct was reduced 20%, suggesting that most Ser/Thr phosphorylation sites are located outside of the C terminus.	cho	14-17	insulin	Cricetulus griseus	25-32
1848554-4	1991	The cells transfected with the wild-type cDNA (CHO-ACE) express a membrane-bound ectoenzyme with an intracellular C terminus, as shown by indirect immunofluorescence using an antiserum (28A7) raised against a synthetic peptide corresponding to the deduced C terminus of ACE.	cho	47-50	angiotensin I converting enzyme	Homo sapiens	51-54
1848554-4	1991	The cells transfected with the wild-type cDNA (CHO-ACE) express a membrane-bound ectoenzyme with an intracellular C terminus, as shown by indirect immunofluorescence using an antiserum (28A7) raised against a synthetic peptide corresponding to the deduced C terminus of ACE.	cho	47-50	angiotensin I converting enzyme	Homo sapiens	270-273
1848554-8	1991	On the other hand, the transfected cells expressing the C-terminally truncated mutant (CHO-ACE delta COOH) do not retain ACE in the plasma membrane, but secrete it into the medium.	cho	87-90	angiotensin I converting enzyme	Homo sapiens	91-94
2250023-2	1990	We now provide evidence that insulin stimulation of myristoyl-diacylglycerol (DAG) production is also markedly impaired in CHO-Y2 cells; this is manifested as a decreased responsiveness and sensitivity to insulin as compared with CHO-R and parental CHO cells.	cho	123-126	insulin	Cricetulus griseus	29-36
1848818-6	1991	It is therefore likely that the pattern of ligand binding and adenylate cyclase activation, mediated by the new beta 3 AR in CHO cells, also reflects the yet-undetermined pharmacological profile in humans.	cho	125-128	adrenoceptor beta 3	Homo sapiens	112-121
2250023-2	1990	We now provide evidence that insulin stimulation of myristoyl-diacylglycerol (DAG) production is also markedly impaired in CHO-Y2 cells; this is manifested as a decreased responsiveness and sensitivity to insulin as compared with CHO-R and parental CHO cells.	cho	123-126	insulin	Cricetulus griseus	205-212
2250023-2	1990	We now provide evidence that insulin stimulation of myristoyl-diacylglycerol (DAG) production is also markedly impaired in CHO-Y2 cells; this is manifested as a decreased responsiveness and sensitivity to insulin as compared with CHO-R and parental CHO cells.	cho	230-233	insulin	Cricetulus griseus	29-36
2096010-5	1990	We selected a high expressing recombinant TPO positive cell population (CHO-TPO) by Northern blot analysis, then fluorescence laser flow cytometry using both human polyclonal and murine monoclonal anti-TPO antibodies.	cho	72-75	thyroid peroxidase	Homo sapiens	42-45
2096010-5	1990	We selected a high expressing recombinant TPO positive cell population (CHO-TPO) by Northern blot analysis, then fluorescence laser flow cytometry using both human polyclonal and murine monoclonal anti-TPO antibodies.	cho	72-75	thyroid peroxidase	Homo sapiens	76-79
2096010-5	1990	We selected a high expressing recombinant TPO positive cell population (CHO-TPO) by Northern blot analysis, then fluorescence laser flow cytometry using both human polyclonal and murine monoclonal anti-TPO antibodies.	cho	72-75	thyroid peroxidase	Homo sapiens	76-79
2306248-7	1990	beta 2-3 and beta 2-5 were resistant to 1.4- and 3.0-fold higher doses of CDDP than CHO, respectively, but beta 1-1 was not.	cho	84-87	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-8
2141816-2	1990	Here, we determined the in vitro and in vivo bioactivity of recombinant FSH produced by CHO mutant cells deficient in the glycosylation enzyme N-acetylglucosamine transferase-I (NAGT-), resulting in glycoproteins with asparagine-linked (GlcNAc)2(Mannose)5 oligosaccharides, or mutant cells defective in sialic acid transport into the Golgi (ST-).	cho	88-91	solute carrier family 5 member 1	Homo sapiens	178-182
2356282-1	1990	Average intracellular pH (pHi) was measured in Chinese hamster ovary (CHO) and murine NG 108-15 neuroblastoma cells by the weak acid, [14C]5,5-dimethyl-2,4-oxazolidinedione-2 [( 14C]-DMO).	cho	70-73	glucose-6-phosphate isomerase	Cricetulus griseus	26-29
2274058-5	1990	In pulse-chase experiments, CHO cells expressing the truncated hTPO protein secreted immunoprecipitable TPO into the culture medium after 4 h of chase, with levels accumulating progressively over a 24-h period.	cho	28-31	thyroid peroxidase	Homo sapiens	63-67
2274058-5	1990	In pulse-chase experiments, CHO cells expressing the truncated hTPO protein secreted immunoprecipitable TPO into the culture medium after 4 h of chase, with levels accumulating progressively over a 24-h period.	cho	28-31	LOW QUALITY PROTEIN: thyroid peroxidase	Cricetulus griseus	64-67
2164219-7	1990	Transfected COS cells expressing the B7/BB-1 antigen adhered to CD28+ CHO cells; this adhesion was blocked by mAbs to CD28 and B7/BB-1.	cho	70-73	T-cell-specific surface glycoprotein CD28	Cricetulus griseus	64-68
2164219-7	1990	Transfected COS cells expressing the B7/BB-1 antigen adhered to CD28+ CHO cells; this adhesion was blocked by mAbs to CD28 and B7/BB-1.	cho	70-73	T-cell-specific surface glycoprotein CD28	Cricetulus griseus	118-122
2306248-7	1990	beta 2-3 and beta 2-5 were resistant to 1.4- and 3.0-fold higher doses of CDDP than CHO, respectively, but beta 1-1 was not.	cho	84-87	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	13-21
3128350-1	1988	In this cooperative study, we explored the role of the carbohydrate moiety (CHO) of von Willebrand factor (vWF) in supporting platelet adhesion.	cho	76-79	von Willebrand factor	Homo sapiens	84-105
2677679-9	1989	Treatment of the transfected CHO cells with weak bases (NH4Cl and chloroquine), or a monovalent ionophore (monensin), prevented proteolytic processing of the TGF-beta 1 precursor indicating that cleavage occurs by proteases in an acidic cellular compartment.	cho	29-32	transforming growth factor beta-1 proprotein	Cricetulus griseus	158-168
2206555-5	1990	Analysis of serum- and cell-free media from recombinant CHO cells metabolically labeled with [3H]glucosamine and [32P]orthophosphate indicated that pro-TGF-beta 2 was glycosylated and phosphorylated.	cho	56-59	transforming growth factor beta-2 proprotein	Cricetulus griseus	152-162
2715185-6	1989	Glucose uptake in both CHO and CIR-0 was significantly enhanced by exogenous insulin, but not in Monr-31, MIR-2, and MIR-15.	cho	23-26	insulin	Cricetulus griseus	77-84
2715185-7	1989	The beta-subunits of insulin receptor in CHO, CIR-0, Monr-31, and MIR-2 were similarly phosphorylated.	cho	41-44	insulin	Cricetulus griseus	21-28
3128350-1	1988	In this cooperative study, we explored the role of the carbohydrate moiety (CHO) of von Willebrand factor (vWF) in supporting platelet adhesion.	cho	76-79	von Willebrand factor	Homo sapiens	107-110
3128350-3	1988	Under our conditions, CHO-modified vWF preparations contained less than 5% of the initial sialic acid ([Neu]-ase-vWF) and less than 45% ([Neu-Gal]-ase-vWF) or 21% ([Neu-Gal-eF]-ase-vWF) of the D-galactose.	cho	22-25	von Willebrand factor	Homo sapiens	35-38
3128350-3	1988	Under our conditions, CHO-modified vWF preparations contained less than 5% of the initial sialic acid ([Neu]-ase-vWF) and less than 45% ([Neu-Gal]-ase-vWF) or 21% ([Neu-Gal-eF]-ase-vWF) of the D-galactose.	cho	22-25	von Willebrand factor	Homo sapiens	113-116
3128350-3	1988	Under our conditions, CHO-modified vWF preparations contained less than 5% of the initial sialic acid ([Neu]-ase-vWF) and less than 45% ([Neu-Gal]-ase-vWF) or 21% ([Neu-Gal-eF]-ase-vWF) of the D-galactose.	cho	22-25	galanin and GMAP prepropeptide	Homo sapiens	142-145
3128350-3	1988	Under our conditions, CHO-modified vWF preparations contained less than 5% of the initial sialic acid ([Neu]-ase-vWF) and less than 45% ([Neu-Gal]-ase-vWF) or 21% ([Neu-Gal-eF]-ase-vWF) of the D-galactose.	cho	22-25	von Willebrand factor	Homo sapiens	113-116
3128350-3	1988	Under our conditions, CHO-modified vWF preparations contained less than 5% of the initial sialic acid ([Neu]-ase-vWF) and less than 45% ([Neu-Gal]-ase-vWF) or 21% ([Neu-Gal-eF]-ase-vWF) of the D-galactose.	cho	22-25	galanin and GMAP prepropeptide	Homo sapiens	169-172
3128350-3	1988	Under our conditions, CHO-modified vWF preparations contained less than 5% of the initial sialic acid ([Neu]-ase-vWF) and less than 45% ([Neu-Gal]-ase-vWF) or 21% ([Neu-Gal-eF]-ase-vWF) of the D-galactose.	cho	22-25	von Willebrand factor	Homo sapiens	113-116
2835663-10	1988	ERCC2 corrects only the first of the five CHO complementation groups of incision-defective mutants.	cho	42-45	general transcription and DNA repair factor IIH helicase subunit XPD	Cricetulus griseus	0-5
3106525-2	1986	One preparation of CHO-derived IFN-gamma showed three bands, with the middle band being a doublet, in a SDS-polyacrylamide gel.	cho	19-22	interferon gamma	Homo sapiens	31-40
3805025-8	1987	Addition of exogenous LDL to culture medium down-regulates the LDL receptor activity of CHO, hyb-2, and hyb-3 cells, whereas no such down-regulation is seen in Monr-31 cells.	cho	88-91	low-density lipoprotein receptor	Cricetulus griseus	63-75
2842659-7	1987	The two mutant hIRs mediate very different physiological responses in transfected cells: the membrane-anchored, but not the cytosolic, hIR TPK mediates a constitutively elevated (135% the maximum insulin-stimulated response in CHO cells) insulin-independent uptake of 2-deoxyglucose.	cho	227-230	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	15-18
2842659-7	1987	The two mutant hIRs mediate very different physiological responses in transfected cells: the membrane-anchored, but not the cytosolic, hIR TPK mediates a constitutively elevated (135% the maximum insulin-stimulated response in CHO cells) insulin-independent uptake of 2-deoxyglucose.	cho	227-230	insulin	Cricetulus griseus	196-203
2842659-7	1987	The two mutant hIRs mediate very different physiological responses in transfected cells: the membrane-anchored, but not the cytosolic, hIR TPK mediates a constitutively elevated (135% the maximum insulin-stimulated response in CHO cells) insulin-independent uptake of 2-deoxyglucose.	cho	227-230	insulin	Cricetulus griseus	238-245
3308456-8	1987	On Day 4 plasma insulin was higher (p less than 0.05) on the high CHO diet than on the low CHO diet and declined progressively on both diets.	cho	66-69	insulin	Homo sapiens	16-23
3308456-8	1987	On Day 4 plasma insulin was higher (p less than 0.05) on the high CHO diet than on the low CHO diet and declined progressively on both diets.	cho	91-94	insulin	Homo sapiens	16-23
3106525-5	1986	The circular dichroic (CD) spectra showed that conformation of the CHO-derived IFN-gamma is similar in the native state, in acid, and after renaturation from acid to the E. coli-derived IFN-gamma.	cho	67-70	interferon gamma	Homo sapiens	79-88
3106525-5	1986	The circular dichroic (CD) spectra showed that conformation of the CHO-derived IFN-gamma is similar in the native state, in acid, and after renaturation from acid to the E. coli-derived IFN-gamma.	cho	67-70	interferon gamma	Homo sapiens	186-195
3017977-2	1986	A functional human EGF-receptor is expressed on the surface of heterologous CHO cells with the following properties: it exhibits typical high affinity (10%; Kd = 3 X 10(-10) M) and low affinity (90%; Kd = 3 X 10(-9) M) binding sites for 125I-EGF; it is expressed as a polypeptide of 170,000 molecular weight with intrinsic protein tyrosine kinase activity.	cho	76-79	epidermal growth factor receptor	Homo sapiens	19-31
3017977-2	1986	A functional human EGF-receptor is expressed on the surface of heterologous CHO cells with the following properties: it exhibits typical high affinity (10%; Kd = 3 X 10(-10) M) and low affinity (90%; Kd = 3 X 10(-9) M) binding sites for 125I-EGF; it is expressed as a polypeptide of 170,000 molecular weight with intrinsic protein tyrosine kinase activity.	cho	76-79	LOW QUALITY PROTEIN: pro-epidermal growth factor	Cricetulus griseus	19-22
6391490-3	1984	Furthermore, two CHO cell glycosylation mutants, B4-2-1, lacking high mannose containing glycoproteins, and Lec 1.3c, lacking complex carbohydrate containing glycoproteins, bind insulin with a much higher and lower affinity respectively than wild type cells.	cho	17-20	insulin	Cricetulus griseus	178-185
6089204-5	1984	Complementation tests between CHO cells and human fibroblasts suggested that the defects in mutants of the ldlA complementation group are analogous to those in a patient with homozygous familial hypercholesterolemia.	cho	30-33	low-density lipoprotein receptor	Cricetulus griseus	107-111
6371028-11	1984	The cellular uptake of 2-[3H]deoxyglucose into CHO cells was significantly enhanced in the presence of insulin, but only slight, if any, increase was observed in MonR cells.	cho	47-50	insulin	Cricetulus griseus	103-110