PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32464592-2	2020	Herein we evaluate binding of androstenedione, testosterone, and 7-hydroxyflavone to CYP19A1, also known as aromatase, in phospholipid nanodiscs by stopped-flow UV-vis spectroscopy.	7-hydroxyflavone	65-81	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	85-92
35193476-8	2022	Further, the molecular docking and molecular dynamics simulation studies result shows that 7-hydroxy flavone has the better binding ability with anti-apoptotic Bcl-2 protein with the estimated free energy of binding of -6.3 kcal/mol.	7-hydroxyflavone	91-108	BCL2 apoptosis regulator	Homo sapiens	160-165
33201683-4	2020	In V79-hCYP1A1 and C3A cells, all compounds induced double-strand DNA breaks and micronuclei formation, which were blocked/significantly attenuated by 1-aminobenzotriazole (CYP inhibitor) or 7-hydroxyflavone (selective CYP1A1 inhibitor).	7-hydroxyflavone	191-207	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	7-14
32464592-6	2020	In addition, 7-hydroxyflavone binds to CYP19A1 nanodiscs with comparable affinity to the substrates and induces an unusual spectral response likely attributable to hydrogen bonding to, rather than displacement of the heme-coordinated water molecule.	7-hydroxyflavone	13-29	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	39-46
23611783-7	2013	Surprisingly, 3-hydroxyflavone was sulfated only by AtSULT202A1 while 7-hydroxyflavone was highly sulfated by AtSULT202E1 and AtSULT202B1.	7-hydroxyflavone	70-86	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	110-121
24664133-6	2014	7-hydroxyflavone (HF) and its phosphate ester(FIP) were predicted to bind with EV71 3Cpro.In an in vitro protease inhibition assay, FIP inhibited EV71 3Cpro protease activity.	7-hydroxyflavone	0-16	upstream transcription factor 2, c-fos interacting	Homo sapiens	132-135
28640852-5	2017	Our data clearly demonstrates, for the first time, that while both 3HF and 7HF protect renal cells from NIC-associated cytotoxicity, the mechanism of their action is different: 3HF elicits protective activity via the PKA/CREB/MnSOD pathway while 7HF does so via the ERK/Nrf2/HO-1 pathway.	7-hydroxyflavone	75-78	cAMP responsive element binding protein 1	Rattus norvegicus	221-225
28640852-5	2017	Our data clearly demonstrates, for the first time, that while both 3HF and 7HF protect renal cells from NIC-associated cytotoxicity, the mechanism of their action is different: 3HF elicits protective activity via the PKA/CREB/MnSOD pathway while 7HF does so via the ERK/Nrf2/HO-1 pathway.	7-hydroxyflavone	75-78	superoxide dismutase 2	Rattus norvegicus	226-231
28640852-5	2017	Our data clearly demonstrates, for the first time, that while both 3HF and 7HF protect renal cells from NIC-associated cytotoxicity, the mechanism of their action is different: 3HF elicits protective activity via the PKA/CREB/MnSOD pathway while 7HF does so via the ERK/Nrf2/HO-1 pathway.	7-hydroxyflavone	75-78	Eph receptor B1	Rattus norvegicus	266-269
28640852-5	2017	Our data clearly demonstrates, for the first time, that while both 3HF and 7HF protect renal cells from NIC-associated cytotoxicity, the mechanism of their action is different: 3HF elicits protective activity via the PKA/CREB/MnSOD pathway while 7HF does so via the ERK/Nrf2/HO-1 pathway.	7-hydroxyflavone	75-78	NFE2 like bZIP transcription factor 2	Rattus norvegicus	270-274
28640852-5	2017	Our data clearly demonstrates, for the first time, that while both 3HF and 7HF protect renal cells from NIC-associated cytotoxicity, the mechanism of their action is different: 3HF elicits protective activity via the PKA/CREB/MnSOD pathway while 7HF does so via the ERK/Nrf2/HO-1 pathway.	7-hydroxyflavone	75-78	heme oxygenase 1	Rattus norvegicus	275-279
28640852-6	2017	Molecular docking and dynamics simulations with two major signaling pathway proteins showed significant differences in the binding energies of 3HF (-5.67 and -7.39 kcal.mol-1) compared to 7HF (-5.41 and -8.55 kcal.mol-1) in the matrices of CREB and Keap1-Nrf2 proteins respectively, which corroborate with the observed differences in their protective properties in the renal cells.	7-hydroxyflavone	188-191	cAMP responsive element binding protein 1	Rattus norvegicus	240-244
28640852-6	2017	Molecular docking and dynamics simulations with two major signaling pathway proteins showed significant differences in the binding energies of 3HF (-5.67 and -7.39 kcal.mol-1) compared to 7HF (-5.41 and -8.55 kcal.mol-1) in the matrices of CREB and Keap1-Nrf2 proteins respectively, which corroborate with the observed differences in their protective properties in the renal cells.	7-hydroxyflavone	188-191	NFE2 like bZIP transcription factor 2	Rattus norvegicus	255-259
28587286-3	2017	The aim of this work was to analyze the improvement of the anticancer effect of rhsTRAIL (recombinant human soluble TRAIL) by nine flavones: 5-Hydroxyflavone, 6-Hydroxyflavone, 7-Hydroxyflavone and their new synthetic derivatives 5-acetoxyflavone, 5-butyryloxyflavone, 6-acetoxyflavone, 6-butyryloxyflavone, 7-acetoxyflavone and 7-butyryloxyflavone.	7-hydroxyflavone	177-193	TNF superfamily member 10	Homo sapiens	83-88
25388478-4	2015	Apigenin, wogonin, flavone, 3-hydroxyflavone, 5-hydroxyflavone, 6-hydroxyflavone, and 7-hydroxyflavone effectively inhibited PKM2, with IC50 in the range of 0.99-2.120 muM.	7-hydroxyflavone	86-102	pyruvate kinase M1/2	Homo sapiens	125-129
24795772-5	2014	The results showed that 6-hydroxyflavone (6-OH-F) and 7-hydroxyflavone (7-OH-F) stimulated ALP activity.	7-hydroxyflavone	54-70	alopecia, recessive	Mus musculus	91-94
23611783-7	2013	Surprisingly, 3-hydroxyflavone was sulfated only by AtSULT202A1 while 7-hydroxyflavone was highly sulfated by AtSULT202E1 and AtSULT202B1.	7-hydroxyflavone	70-86	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	126-137
17624765-1	2007	Previous studies have shown chrysin, 7-hydroxyflavone and 7,4"-dihydroxyflavone to be the most potent flavonoid inhibitors of aromatase.	7-hydroxyflavone	37-53	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	126-135
19074529-1	2009	This article describes an in vitro investigation of the inhibition of cytochrome P450 (P450) 2C9 by a series of flavonoids made up of flavones (flavone, 6-hydroxyflavone, 7-hydroxyflavone, chrysin, baicalein, apigenin, luteolin, scutellarein, and wogonin) and flavonols (galangin, fisetin, kaempferol, morin, and quercetin).	7-hydroxyflavone	171-187	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-96
18552875-6	2008	Among flavonoids with a more restricted distribution in nature, the two most active toward FAAH were 7-hydroxyflavone (IC(50) value of 0.5-1 microM depending on the solvent used) and 3,7-dihydroxyflavone (IC(50) value 2.2 microM).	7-hydroxyflavone	101-117	fatty-acid amide hydrolase-like	Rattus norvegicus	91-95
11595503-2	2001	Several flavonoids such as 7-hydroxyflavone and chrysin (5,7-dihydroxyflavone) were shown to inhibit the formation of 3H-17beta-estradiol from 3H-androstenedione (IC(50)<1.0 microM) in human choriocarcinoma JEG-3 cells and in human embryonic kidney cells HEK 293 transfected with human aromatase gene (Arom+HEK 293).	7-hydroxyflavone	27-43	PARP1 binding protein	Homo sapiens	305-309
9929167-5	1998	We found that 7-hydroxyflavone and apigenin are the most effective aromatase and 17beta-hydroxysteroid dehydrogenase inhibitors, respectively.	7-hydroxyflavone	14-30	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	67-76
9929167-5	1998	We found that 7-hydroxyflavone and apigenin are the most effective aromatase and 17beta-hydroxysteroid dehydrogenase inhibitors, respectively.	7-hydroxyflavone	14-30	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	81-116
9763404-5	1998	For CYP1A1, 7-hydroxyflavone exhibited a competitive mode of inhibition, with a Ki value of 0.015 microM and 6-fold selectivity for CYP1A1 over CYP1A2.	7-hydroxyflavone	12-28	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	4-10
9763404-5	1998	For CYP1A1, 7-hydroxyflavone exhibited a competitive mode of inhibition, with a Ki value of 0.015 microM and 6-fold selectivity for CYP1A1 over CYP1A2.	7-hydroxyflavone	12-28	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-138
9763404-5	1998	For CYP1A1, 7-hydroxyflavone exhibited a competitive mode of inhibition, with a Ki value of 0.015 microM and 6-fold selectivity for CYP1A1 over CYP1A2.	7-hydroxyflavone	12-28	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	144-150