PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35432723-9	2022	Furthermore, GDN treatment notably dose-dependently decreased the mRNA and protein expression of iNOS in LPS-induced macrophages.	gedunin	13-16	inositol-3-phosphate synthase 1	Homo sapiens	97-101
22605339-8	2012	Subsequent biochemical screening of 21 limonoids revealed that some of them, such as 8beta-hydroxycarapin-3,8-hemiacetal and gedunin, which exhibits anti-cancer activity, inhibited SM biosynthesis and CERT-mediated extraction of Cer from membranes.	gedunin	125-132	ceramide transporter 1	Homo sapiens	201-205
33634871-9	2021	PRACTICAL APPLICATIONS: Bisdemethoxycurcumin from C. longa and limonoids, namely, azadiradione and gedunin, from A. indica are potent inhibitors of the antidiabetic target human pancreatic alpha-amylase.	gedunin	99-106	amylase alpha 2A	Homo sapiens	178-202
29471019-7	2018	Administration of the p23 inhibitor gedunin was also neuroprotective in these cells as well as in human induced pluripotent stem cell (iPSC)-derived neurons.	gedunin	36-43	prostaglandin E synthase 3	Homo sapiens	22-25
33490651-6	2021	A significant restoration of activities of cellular antioxidant enzymes; superoxide dismutase, catalase and glutathione peroxidase in the presence of Gedunin revealed its ability to reduce oxidative stress.	gedunin	150-157	catalase	Homo sapiens	95-103
33490651-7	2021	These results substantiated Gedunin as a bona fide inhibitor of human NOX5 and a ROS scavenging antioxidant with promising therapeutic attributes including its natural origin and inhibition of multiple diabetic targets.	gedunin	28-35	NADPH oxidase 5	Homo sapiens	70-74
33100613-8	2020	The study identified that gedunin, epoxyazadiradione, nimbin and ginsenosides have potential to inhibit Mpro activity and their binding energies are - 9.51 kcal/mol, - 8.47 kcal/mol, - 8.66 kcal/mol and - 9.63 kcal/mol respectively.	gedunin	26-33	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	104-108
32585246-12	2020	Moreover, Hsp90 inhibition by gedunin did not cause upregulation of Hsp70 expression.	gedunin	30-37	heat shock protein 90 alpha family class A member 1	Homo sapiens	10-15
32585246-13	2020	SIGNIFICANCE: Gedunin induces apoptosis in lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and autophagy downregulation, thus making gedunin a good drug lead for targeting lung cancer.	gedunin	14-21	heat shock protein 90 alpha family class A member 1	Homo sapiens	75-80
32585246-13	2020	SIGNIFICANCE: Gedunin induces apoptosis in lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and autophagy downregulation, thus making gedunin a good drug lead for targeting lung cancer.	gedunin	14-21	beclin 1	Homo sapiens	81-89
32585246-13	2020	SIGNIFICANCE: Gedunin induces apoptosis in lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and autophagy downregulation, thus making gedunin a good drug lead for targeting lung cancer.	gedunin	14-21	BCL2 apoptosis regulator	Homo sapiens	90-95
32585246-13	2020	SIGNIFICANCE: Gedunin induces apoptosis in lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and autophagy downregulation, thus making gedunin a good drug lead for targeting lung cancer.	gedunin	150-157	beclin 1	Homo sapiens	81-89
32585246-13	2020	SIGNIFICANCE: Gedunin induces apoptosis in lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and autophagy downregulation, thus making gedunin a good drug lead for targeting lung cancer.	gedunin	150-157	BCL2 apoptosis regulator	Homo sapiens	90-95
26227505-6	2015	Recently, several plant-derived small molecules have been discovered exhibiting inhibitory activity towards Hsp90, such as epigallocatechin gallate, gedunin, lentiginosine, celastrol, and deguelin.	gedunin	149-156	heat shock protein 90 alpha family class A member 1	Homo sapiens	108-113