PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18762714-3	2008	Urinary excretion of L-FABP increased after administration of cephaloridine in most of the Tg mice, whereas glomerular filtration markers such as blood-urea-nitrogen (BUN) and plasma creatinine (CRE) were almost unchanged.	Cephaloridine	62-75	fatty acid binding protein 1, liver	Mus musculus	21-27
24988337-6	2014	The fractional bleaching of tPA-cerulean (tPA-cer) was greater when subsequently probed with TIR excitation than with epifluorescence, indicating that tPA-cer mobility was low.	Cephaloridine	32-35	plasminogen activator, tissue type	Bos taurus	28-31
24988337-6	2014	The fractional bleaching of tPA-cerulean (tPA-cer) was greater when subsequently probed with TIR excitation than with epifluorescence, indicating that tPA-cer mobility was low.	Cephaloridine	32-35	plasminogen activator, tissue type	Bos taurus	42-45
24988337-6	2014	The fractional bleaching of tPA-cerulean (tPA-cer) was greater when subsequently probed with TIR excitation than with epifluorescence, indicating that tPA-cer mobility was low.	Cephaloridine	32-35	plasminogen activator, tissue type	Bos taurus	42-45
20831193-3	2010	A second objective was to assess two high renal clearance drugs that interact with OCTN2 in vitro (cetirizine and cephaloridine) for possible OCTN2-mediated drug-drug interactions.	Cephaloridine	114-127	solute carrier family 22 member 5	Homo sapiens	83-88
20831193-3	2010	A second objective was to assess two high renal clearance drugs that interact with OCTN2 in vitro (cetirizine and cephaloridine) for possible OCTN2-mediated drug-drug interactions.	Cephaloridine	114-127	solute carrier family 22 member 5	Homo sapiens	142-147
19220985-2	2009	The purpose of the present study was to elucidate the involvement of OCTN2 in renal disposition of a beta-lactam antibiotic, cephaloridine (CER), based on experiments with juvenile visceral steatosis (jvs) mice, which have a functional deficiency of the octn2 gene.	Cephaloridine	125-138	solute carrier family 22 (organic cation transporter), member 5	Mus musculus	69-74
19220985-2	2009	The purpose of the present study was to elucidate the involvement of OCTN2 in renal disposition of a beta-lactam antibiotic, cephaloridine (CER), based on experiments with juvenile visceral steatosis (jvs) mice, which have a functional deficiency of the octn2 gene.	Cephaloridine	140-143	solute carrier family 22 (organic cation transporter), member 5	Mus musculus	69-74
18426979-5	2008	Because cisplatin activates acid sphingomyelinase (ASMase), we investigate here the role of the ASMase/ceramide (Cer) pathway in mediating these morphological changes.	Cephaloridine	113-116	sphingomyelin phosphodiesterase 1	Homo sapiens	96-102
16997449-2	2006	p-Aminohippurate uptake exhibited similar kinetics as published values, was inhibited by cephaloridine, cimetidine, methotrexate, and urate, consistent with function of both organic anion transporter 1 (OAT1) and OAT3.	Cephaloridine	89-102	solute carrier family 22 member 6	Homo sapiens	203-207
16154539-3	2005	We have already demonstrated that cephaloridine, a nephrotoxic antibiotic, leads to extracellular signal-regulated protein kinase (ERK) activation in the rat kidney, which probably contributes to cephaloridine-induced renal dysfunction.	Cephaloridine	34-47	Eph receptor B1	Rattus norvegicus	84-129
16239287-4	2005	RESULTS: Clavulanic acid, cefoxitin and cefaloridine were the most potent inhibitors of IFN-gamma activity, followed by cefotaxime, ceftriaxone and phenoxymethylpenicillin.	Cephaloridine	40-52	interferon gamma	Homo sapiens	88-97
16272694-2	2005	In the present study, we examined the effect of FTS on cephaloridine (CER)-induced nephrotoxicity in vivo and in vitro.	Cephaloridine	55-68	AKT interacting protein	Rattus norvegicus	48-51
16154539-3	2005	We have already demonstrated that cephaloridine, a nephrotoxic antibiotic, leads to extracellular signal-regulated protein kinase (ERK) activation in the rat kidney, which probably contributes to cephaloridine-induced renal dysfunction.	Cephaloridine	34-47	Eph receptor B1	Rattus norvegicus	131-134
16272694-2	2005	In the present study, we examined the effect of FTS on cephaloridine (CER)-induced nephrotoxicity in vivo and in vitro.	Cephaloridine	70-73	AKT interacting protein	Rattus norvegicus	48-51
16154539-3	2005	We have already demonstrated that cephaloridine, a nephrotoxic antibiotic, leads to extracellular signal-regulated protein kinase (ERK) activation in the rat kidney, which probably contributes to cephaloridine-induced renal dysfunction.	Cephaloridine	196-209	Eph receptor B1	Rattus norvegicus	84-129
16154539-3	2005	We have already demonstrated that cephaloridine, a nephrotoxic antibiotic, leads to extracellular signal-regulated protein kinase (ERK) activation in the rat kidney, which probably contributes to cephaloridine-induced renal dysfunction.	Cephaloridine	196-209	Eph receptor B1	Rattus norvegicus	131-134
15991025-7	2005	Citrate synthase and glutamine synthetase activities were also inhibited by cephaloridine, but to a much lesser extent.	Cephaloridine	76-89	citrate synthase, mitochondrial	Oryctolagus cuniculus	0-16
16272694-10	2005	In vitro treatment of the established cell line, LLC-PK1 cells, with FTS significantly ameliorated CER-induced cell injury, as measured by lactate dehydrogenase (LDH) leakage.	Cephaloridine	99-102	AKT interacting protein	Mus musculus	69-72
16098483-7	2005	The uptake of cephaloridine, cefdinir and cefotiam by HEK-hOAT3 was 35-50-fold greater than that by control cells.	Cephaloridine	14-27	solute carrier family 22 member 8	Homo sapiens	58-63
16098483-1	2005	We examined the substrate specificity of human organic anion transporter (hOAT) 1 and hOAT3 for various cephalosporin antibiotics, cephaloridine, cefdinir, cefotiam, ceftibuten, cefaclor, ceftizoxime, cefoselis and cefazolin by using HEK293 cells stably transfected with hOAT1 or hOAT3 cDNA (HEK-hOAT1, HEK-hOAT3).	Cephaloridine	131-144	solute carrier family 22 member 6	Homo sapiens	47-81
16098483-1	2005	We examined the substrate specificity of human organic anion transporter (hOAT) 1 and hOAT3 for various cephalosporin antibiotics, cephaloridine, cefdinir, cefotiam, ceftibuten, cefaclor, ceftizoxime, cefoselis and cefazolin by using HEK293 cells stably transfected with hOAT1 or hOAT3 cDNA (HEK-hOAT1, HEK-hOAT3).	Cephaloridine	131-144	solute carrier family 22 member 8	Homo sapiens	86-91
12749822-0	2003	Involvement of MEK/ERK pathway in cephaloridine-induced injury in rat renal cortical slices.	Cephaloridine	34-47	Eph receptor B1	Rattus norvegicus	19-22
15879677-0	2005	Cephaloridine induces translocation of protein kinase C delta into mitochondria and enhances mitochondrial generation of free radicals in the kidney cortex of rats causing renal dysfunction.	Cephaloridine	0-13	protein kinase C, delta	Rattus norvegicus	39-61
15879677-1	2005	We have previously reported that the enhancement of free radical generation in mitochondria isolated from the kidney cortex of rats exposed to cephaloridine (CER) is probably mediated by the activation of protein kinase C (PKC).	Cephaloridine	143-156	protein kinase C, delta	Rattus norvegicus	223-226
15879677-1	2005	We have previously reported that the enhancement of free radical generation in mitochondria isolated from the kidney cortex of rats exposed to cephaloridine (CER) is probably mediated by the activation of protein kinase C (PKC).	Cephaloridine	158-161	protein kinase C, delta	Rattus norvegicus	223-226
15722450-2	2005	The G262S point mutation distinguishing the metallo-beta-lactamase IMP-1 from IMP-6 has no effect on the hydrolysis of the drugs cephalothin and cefotaxime, but significantly improves catalytic efficiency toward cephaloridine, ceftazidime, benzylpenicillin, ampicillin, and imipenem.	Cephaloridine	212-225	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	67-72
8584014-1	1995	The alteration of Ca(2+)-binding protein regucalcin mRNA expression in the kidney cortex of rats administered cisplatin and cephaloridine, which can induce kidney damage, was investigated.	Cephaloridine	124-137	regucalcin	Rattus norvegicus	41-51
12650826-8	2003	Cephaloridine significantly decreased the viability of cells stably expressing human-OAT2, human-OAT1, human-OAT3 and human-OAT4.	Cephaloridine	0-13	solute carrier family 22 member 7	Homo sapiens	85-89
12650826-8	2003	Cephaloridine significantly decreased the viability of cells stably expressing human-OAT2, human-OAT1, human-OAT3 and human-OAT4.	Cephaloridine	0-13	solute carrier family 22 member 6	Homo sapiens	97-101
12650826-8	2003	Cephaloridine significantly decreased the viability of cells stably expressing human-OAT2, human-OAT1, human-OAT3 and human-OAT4.	Cephaloridine	0-13	solute carrier family 22 member 8	Homo sapiens	109-113
12650826-8	2003	Cephaloridine significantly decreased the viability of cells stably expressing human-OAT2, human-OAT1, human-OAT3 and human-OAT4.	Cephaloridine	0-13	solute carrier family 22 member 11	Homo sapiens	124-128
12005172-0	2002	Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1.	Cephaloridine	58-71	solute carrier family 22 member 8	Rattus norvegicus	19-46
12005172-0	2002	Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1.	Cephaloridine	58-71	solute carrier family 22 member 8	Rattus norvegicus	48-53
12005172-1	2002	This study was performed to elucidate the possible involvement of organic anion transporter 3 (OAT3) in cephaloridine (CER)-induced nephrotoxicity and compare the substrate specificity between rOAT3 and rat OAT1 (rOAT1) for various cephalosporin antibiotics, using proximal tubule cells stably expressing rOAT3 (S2 rOAT3) and rOAT1 (S2 rOAT1).	Cephaloridine	104-117	solute carrier family 22 member 8	Rattus norvegicus	66-93
12005172-1	2002	This study was performed to elucidate the possible involvement of organic anion transporter 3 (OAT3) in cephaloridine (CER)-induced nephrotoxicity and compare the substrate specificity between rOAT3 and rat OAT1 (rOAT1) for various cephalosporin antibiotics, using proximal tubule cells stably expressing rOAT3 (S2 rOAT3) and rOAT1 (S2 rOAT1).	Cephaloridine	104-117	solute carrier family 22 member 8	Rattus norvegicus	95-99
12005172-1	2002	This study was performed to elucidate the possible involvement of organic anion transporter 3 (OAT3) in cephaloridine (CER)-induced nephrotoxicity and compare the substrate specificity between rOAT3 and rat OAT1 (rOAT1) for various cephalosporin antibiotics, using proximal tubule cells stably expressing rOAT3 (S2 rOAT3) and rOAT1 (S2 rOAT1).	Cephaloridine	119-122	solute carrier family 22 member 8	Rattus norvegicus	66-93
12005172-1	2002	This study was performed to elucidate the possible involvement of organic anion transporter 3 (OAT3) in cephaloridine (CER)-induced nephrotoxicity and compare the substrate specificity between rOAT3 and rat OAT1 (rOAT1) for various cephalosporin antibiotics, using proximal tubule cells stably expressing rOAT3 (S2 rOAT3) and rOAT1 (S2 rOAT1).	Cephaloridine	119-122	solute carrier family 22 member 8	Rattus norvegicus	95-99
11327855-0	2001	Structures of the acyl-enzyme complexes of the Staphylococcus aureus beta-lactamase mutant Glu166Asp:Asn170Gln with benzylpenicillin and cephaloridine.	Cephaloridine	137-150	beta-lactamase	Staphylococcus aureus	69-83
11327855-10	2001	The interactions of the cephaloridine resemble those seen in the structure of the acyl-enzyme of beta-lactamase from Escherichia coli with benzylpenicillin.	Cephaloridine	24-37	beta-lactamase	Escherichia coli	97-111
10636865-5	2000	The beta-lactam antibiotics cephaloridine, cefoselis, cefepime, and cefluprenam were found to inhibit OCTN2-mediated carnitine transport.	Cephaloridine	28-41	solute carrier family 22 member 5	Homo sapiens	102-107
10636865-8	2000	The interaction of cephaloridine with OCTN2 is competitive with respect to carnitine.	Cephaloridine	19-32	solute carrier family 22 member 5	Homo sapiens	38-43
10636865-10	2000	In contrast, cephaloridine, cefoselis, cefepime, and cefluprenam, which were recognized by OCTN2, did not interact with PEPT1 and PEPT2.	Cephaloridine	13-26	solute carrier family 22 member 5	Homo sapiens	91-96
10636865-12	2000	Furthermore, the Na(+)-dependent, OCTN2-mediated cellular uptake of cephaloridine could be demonstrated by direct uptake measurements.	Cephaloridine	68-81	solute carrier family 22 member 5	Homo sapiens	34-39
10636865-13	2000	These studies show that OCTN2 plays a crucial role in the pharmacokinetics and therapeutic efficacy of certain beta-lactam antibiotics such as cephaloridine and that cephaloridine-induced carnitine deficiency is likely to be due to inhibition of carnitine reabsorption in the kidney.	Cephaloridine	143-156	solute carrier family 22 member 5	Homo sapiens	24-29
10594788-0	1999	Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.	Cephaloridine	46-59	solute carrier family 22 member 6	Rattus norvegicus	8-35
10594788-0	1999	Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.	Cephaloridine	46-59	solute carrier family 22 member 6	Rattus norvegicus	37-41
10594788-0	1999	Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.	Cephaloridine	61-64	solute carrier family 22 member 6	Rattus norvegicus	8-35
10594788-0	1999	Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.	Cephaloridine	61-64	solute carrier family 22 member 6	Rattus norvegicus	37-41
10594788-1	1999	UNLABELLED: Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.	Cephaloridine	58-71	solute carrier family 22 member 6	Rattus norvegicus	20-47
10594788-1	1999	UNLABELLED: Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.	Cephaloridine	58-71	solute carrier family 22 member 6	Rattus norvegicus	49-53
10594788-1	1999	UNLABELLED: Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.	Cephaloridine	73-76	solute carrier family 22 member 6	Rattus norvegicus	20-47
10594788-1	1999	UNLABELLED: Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.	Cephaloridine	73-76	solute carrier family 22 member 6	Rattus norvegicus	49-53
10594788-8	1999	RESULTS: S3 rOAT1 expressed a functional organic anion transporter in the cytoplasmic membrane, and exhibited CER uptake activity.	Cephaloridine	110-113	solute carrier family 22 member 6	Rattus norvegicus	12-17
10411577-3	1999	Penicillin G, carbenicillin, cephaloridine, cephalothin, cefazolin, and cephalexin inhibited [(14)C]PAH uptake via OAT1 in a competitive manner (K(i) = 0.29-2.33 mM).	Cephaloridine	29-42	solute carrier family 22 member 6	Rattus norvegicus	115-119
10411577-8	1999	Cells expressing OAT1 showed higher susceptibility to cephaloridine (a potentially nephrotoxic beta-lactam antibiotic) toxicity than did control cells.	Cephaloridine	54-67	solute carrier family 22 member 6	Rattus norvegicus	17-21
11909604-7	2002	The inhibition constant (K(i)) values of cefoperazone, cefazolin, ceftriaxone and cephaloridine for human-OAT1 were much lower than those for human-OAT3 and human-OAT4, whereas the K(i) values of cephalothin and cefotaxime for human-OAT3 were much lower than those for human-OAT1 and human-OAT4.	Cephaloridine	82-95	solute carrier family 22 member 6	Homo sapiens	106-110
11909604-7	2002	The inhibition constant (K(i)) values of cefoperazone, cefazolin, ceftriaxone and cephaloridine for human-OAT1 were much lower than those for human-OAT3 and human-OAT4, whereas the K(i) values of cephalothin and cefotaxime for human-OAT3 were much lower than those for human-OAT1 and human-OAT4.	Cephaloridine	82-95	solute carrier family 22 member 8	Homo sapiens	233-237
11909604-7	2002	The inhibition constant (K(i)) values of cefoperazone, cefazolin, ceftriaxone and cephaloridine for human-OAT1 were much lower than those for human-OAT3 and human-OAT4, whereas the K(i) values of cephalothin and cefotaxime for human-OAT3 were much lower than those for human-OAT1 and human-OAT4.	Cephaloridine	82-95	solute carrier family 22 member 6	Homo sapiens	275-279
11909604-7	2002	The inhibition constant (K(i)) values of cefoperazone, cefazolin, ceftriaxone and cephaloridine for human-OAT1 were much lower than those for human-OAT3 and human-OAT4, whereas the K(i) values of cephalothin and cefotaxime for human-OAT3 were much lower than those for human-OAT1 and human-OAT4.	Cephaloridine	82-95	solute carrier family 22 member 11	Homo sapiens	290-294
11909604-10	2002	Since the K(i) value of cephaloridine for human-OAT4-mediated organic uptake was much higher than that for human-OAT1, the results indicate the possibility that human-OAT4 limits the efflux of cephaloridine, leading to the accumulation of cephaloridine and the induction of nephrotoxicity.	Cephaloridine	24-37	solute carrier family 22 member 11	Homo sapiens	48-52
11909604-10	2002	Since the K(i) value of cephaloridine for human-OAT4-mediated organic uptake was much higher than that for human-OAT1, the results indicate the possibility that human-OAT4 limits the efflux of cephaloridine, leading to the accumulation of cephaloridine and the induction of nephrotoxicity.	Cephaloridine	24-37	solute carrier family 22 member 11	Homo sapiens	167-171
11909604-10	2002	Since the K(i) value of cephaloridine for human-OAT4-mediated organic uptake was much higher than that for human-OAT1, the results indicate the possibility that human-OAT4 limits the efflux of cephaloridine, leading to the accumulation of cephaloridine and the induction of nephrotoxicity.	Cephaloridine	193-206	solute carrier family 22 member 11	Homo sapiens	48-52
11909604-10	2002	Since the K(i) value of cephaloridine for human-OAT4-mediated organic uptake was much higher than that for human-OAT1, the results indicate the possibility that human-OAT4 limits the efflux of cephaloridine, leading to the accumulation of cephaloridine and the induction of nephrotoxicity.	Cephaloridine	193-206	solute carrier family 22 member 6	Homo sapiens	113-117
11909604-10	2002	Since the K(i) value of cephaloridine for human-OAT4-mediated organic uptake was much higher than that for human-OAT1, the results indicate the possibility that human-OAT4 limits the efflux of cephaloridine, leading to the accumulation of cephaloridine and the induction of nephrotoxicity.	Cephaloridine	193-206	solute carrier family 22 member 11	Homo sapiens	167-171
11909604-10	2002	Since the K(i) value of cephaloridine for human-OAT4-mediated organic uptake was much higher than that for human-OAT1, the results indicate the possibility that human-OAT4 limits the efflux of cephaloridine, leading to the accumulation of cephaloridine and the induction of nephrotoxicity.	Cephaloridine	193-206	solute carrier family 22 member 11	Homo sapiens	48-52
11909604-10	2002	Since the K(i) value of cephaloridine for human-OAT4-mediated organic uptake was much higher than that for human-OAT1, the results indicate the possibility that human-OAT4 limits the efflux of cephaloridine, leading to the accumulation of cephaloridine and the induction of nephrotoxicity.	Cephaloridine	193-206	solute carrier family 22 member 6	Homo sapiens	113-117
11909604-10	2002	Since the K(i) value of cephaloridine for human-OAT4-mediated organic uptake was much higher than that for human-OAT1, the results indicate the possibility that human-OAT4 limits the efflux of cephaloridine, leading to the accumulation of cephaloridine and the induction of nephrotoxicity.	Cephaloridine	193-206	solute carrier family 22 member 11	Homo sapiens	167-171
9034621-3	1996	This paper reports a comparative study of the response to cephaloridine exposure of two established cell lines from pig (LLC-PK1) and rabbit (LLC-RK1) kidneys and primary cultures of rat and rabbit proximal tubule cells.	Cephaloridine	58-71	pyruvate kinase L/R	Rattus norvegicus	125-128
8679682-3	1996	The small-angle diffraction curve of the CHOL/CER(1 + 2) mixture at a molar ratio of 0.4 revealed the presence of only one peak at a spacing of 6.7 nm.	Cephaloridine	46-49	CHOL	Sus scrofa	41-45
8679682-13	1996	However, in the CHOL/CER mixtures a lower relative amount of CHOL was required to acquire these lamellar phases, indicating that at low CHOL contents, CER 3, 4, 5 and 6 play a crucial role in the formation of the lamellar phases.	Cephaloridine	21-24	CHOL	Sus scrofa	61-65
8679682-13	1996	However, in the CHOL/CER mixtures a lower relative amount of CHOL was required to acquire these lamellar phases, indicating that at low CHOL contents, CER 3, 4, 5 and 6 play a crucial role in the formation of the lamellar phases.	Cephaloridine	21-24	CHOL	Sus scrofa	61-65
8679682-15	1996	When palmitic acid (PA) was included, the phase behaviour of the CHOL/CER(1 + 2)/PA mixture was more complex.	Cephaloridine	70-73	CHOL	Sus scrofa	65-69
8679682-20	1996	These findings indicate that the lateral packing of mixtures of CHOL/CER(1 + 2) is more complex than that of the CHOL/CER mixtures that reveals a hexagonal lateral packing.	Cephaloridine	69-72	CHOL	Sus scrofa	64-68
8579607-2	1996	Murine IL-2-dependent T lymphocyte CTLL cells metabolize exogenously added Sph to GlcCer through Cer within 30 min, whereas fibroblast BALB/C A31 cells required more than 2 h. Thus, CTLL cells exhibiting the active conversion were used as recipient cells, whereas A31 cells where the conversion was slow and fumonisin B1 (inhibition of Cer biosynthesis)-treated CTLL cells being donor cells.	Cephaloridine	85-88	interleukin 2	Mus musculus	7-11
8584014-5	1995	The expression of regucalcin mRNA in the kidney cortex was markedly reduced by the administration of cisplatin or cephaloridine in rats, when the mRNA levels were analyzed by Northern blotting using rat liver regucalcin cDNA (0.9 kb).	Cephaloridine	114-127	regucalcin	Rattus norvegicus	18-28
8262865-8	1993	These beta-lactamase-related inhibition zone differentials and inoculum effects for the inhibitor combinations resemble previous observations for first-generation cephalosporins, notably cephazolin and cephaloridine.	Cephaloridine	202-215	beta-lactamase	Staphylococcus aureus	6-20
1499375-3	1992	Aztreonam showed a high affinity to chromosomal-mediated cephalosporinase P99, its Ki for inhibition of P99 with cephaloridine as substrate was 0.0159 microns.	Cephaloridine	113-126	protein phosphatase 1 regulatory subunit 10	Homo sapiens	74-77
1499375-3	1992	Aztreonam showed a high affinity to chromosomal-mediated cephalosporinase P99, its Ki for inhibition of P99 with cephaloridine as substrate was 0.0159 microns.	Cephaloridine	113-126	protein phosphatase 1 regulatory subunit 10	Homo sapiens	104-107
35504072-4	2022	The crystallization kinetics showed that at lower cooling rate, the LEC/CER co-assembled crystals grew at 2-3 dimensions by one step crystallization process.	Cephaloridine	72-75	C-C motif chemokine ligand 16	Homo sapiens	68-71
1354458-3	1992	Urine analysis on day 3, after two doses of cephaloridine showed dose-related increases in glucose, total protein, N-acetyl beta-D-glucosaminidase, gamma-glutamyltranspeptidase, alkaline phosphatase and lactate dehydrogenase.	Cephaloridine	44-57	O-GlcNAcase	Rattus norvegicus	115-146
2159880-2	1990	Spatial structures of the oligosaccharide parts of globotriaosylceramide, Gal(alpha 1-4)Gal(beta 1-4)Glc(beta 1-1)Cer (Cer = ceramide) and isoglobotriaosylceramide, Gal(alpha 1-3)Gal(beta 1-4)Glc(beta 1-1)Cer were investigated in (C2H3)2SO solution by means of laboratory and rotating frame NOE, hydroxyl protons being used as long-range sensors defining the distance constraints.	Cephaloridine	114-117	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	92-98
2159880-2	1990	Spatial structures of the oligosaccharide parts of globotriaosylceramide, Gal(alpha 1-4)Gal(beta 1-4)Glc(beta 1-1)Cer (Cer = ceramide) and isoglobotriaosylceramide, Gal(alpha 1-3)Gal(beta 1-4)Glc(beta 1-1)Cer were investigated in (C2H3)2SO solution by means of laboratory and rotating frame NOE, hydroxyl protons being used as long-range sensors defining the distance constraints.	Cephaloridine	114-117	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	105-113
2159880-2	1990	Spatial structures of the oligosaccharide parts of globotriaosylceramide, Gal(alpha 1-4)Gal(beta 1-4)Glc(beta 1-1)Cer (Cer = ceramide) and isoglobotriaosylceramide, Gal(alpha 1-3)Gal(beta 1-4)Glc(beta 1-1)Cer were investigated in (C2H3)2SO solution by means of laboratory and rotating frame NOE, hydroxyl protons being used as long-range sensors defining the distance constraints.	Cephaloridine	114-117	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	105-111
34813948-5	2022	In Acsl1-/- mice, epidermal ceramide (EOS) (Cer(EOS)) containing omega-O-esterified linoleic acid, a lipid essential for the skin barrier, was significantly reduced.	Cephaloridine	44-47	acyl-CoA synthetase long-chain family member 1	Mus musculus	3-8
2930580-7	1989	Cephaloridine depleted GSH and elevated GSSG in renal cortex, inhibited glutathione reductase, and increased both MDA in whole cortex and CDs in cortical microsomes and mitochondria.	Cephaloridine	0-13	glutathione-disulfide reductase	Homo sapiens	72-93
7065646-2	1982	It was shown that sensitivity of NAG-vibrio to chloramphenicol, ampicillin, cephaloridine and streptomycin decreased.	Cephaloridine	76-89	NBAS subunit of NRZ tethering complex	Homo sapiens	33-36
3190753-5	1988	CPH-treatment induced a polypeptide with an apparent molecular weight of 44,000 and decreased the content of cytochrome P-450 isoenzymes in the microsomal fraction.	Cephaloridine	0-3	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	109-125
3178892-0	1988	Depletion of cytochrome P-450 and alterations in activities of drug metabolizing enzymes induced by cephaloridine in the rat kidney cortex.	Cephaloridine	100-113	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	13-29
2986254-5	1985	Conversely, cephaloridine inhibited brush border transport of PAH and NMN in the rat but not in the rabbit.	Cephaloridine	12-25	phenylalanine hydroxylase	Rattus norvegicus	62-65
3967656-4	1985	By the use of high performance liquid chromatography, the three simplest components were isolated and their chemical structures determined: Glc(beta 1-1)Cer, Man(beta 1-4)-Glc(beta 1-1)Cer [with minor component Gal(beta 1-4)Glc(beta 1-1)Cer] and GlcNAc(beta 1-3)Man(beta 1-4)Glc(beta 1-1)-Cer.	Cephaloridine	153-156	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	144-152
6335045-9	1984	Antibiotic resistance to Ampicillin, Cephaloridine, Cephalexine and Cefazolin observed in receiving strains after conjugation is not only due to beta-lactamase transfer.	Cephaloridine	37-50	beta-lactamase	Escherichia coli	145-159
6200139-0	1984	The reversible deactivation of beta-lactamase from Staphylococcus aureus by quinacillin and cephaloridine and its modification by antibodies.	Cephaloridine	92-105	beta-lactamase	Staphylococcus aureus	31-45
6200139-1	1984	The effect of antibody on the reversible deactivation of the beta-lactamase (penicillin amino-beta-lactamhydrolase, EC 3.5.2.6) from Staphylococcus aureus has been studied using quinacillin and cephaloridine as substrates.	Cephaloridine	194-207	beta-lactamase	Staphylococcus aureus	61-75
7130143-6	1982	The structures were identified by partial acid hydrolysis, sequential enzymatic hydrolysis, chromium trioxide oxidation and methylation analysis as: Glc beta (1-1)Cer, Man beta (1-4)Glc beta (1-1)Cer, GlcNAc beta (1-3)Man beta (1-4)Glc beta (1-1)Cer and GalNAc beta (1-4)GlcNAc beta (1-3)Man beta (1-4)Glc(1-1)Cer.	Cephaloridine	163-166	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	153-162
6182073-3	1982	Beta 2-Microglobulin (beta 2-M) was purified from the urine of rats treated with cephaloridine by a combination of ammonium sulfate precipitation, gel chromatography, ion exchange chromatography, zone electrophoresis, and isoelectric focusing.	Cephaloridine	81-94	beta-2 microglobulin	Rattus norvegicus	0-20
6182073-3	1982	Beta 2-Microglobulin (beta 2-M) was purified from the urine of rats treated with cephaloridine by a combination of ammonium sulfate precipitation, gel chromatography, ion exchange chromatography, zone electrophoresis, and isoelectric focusing.	Cephaloridine	81-94	beta-2 microglobulin	Rattus norvegicus	22-30
2752493-7	1989	These results suggest that the rise in the urinary excretion of GAA on the 1st day was ascribable to an inhibitory effect of cephaloridine on renal reabsorption of GAA, and that the fall in its urinary excretion on the 3rd day was ascribable to the suppression in the renal GAA formation system including GAT, arginine and so on.	Cephaloridine	125-138	alpha glucosidase	Rattus norvegicus	64-67
2752493-7	1989	These results suggest that the rise in the urinary excretion of GAA on the 1st day was ascribable to an inhibitory effect of cephaloridine on renal reabsorption of GAA, and that the fall in its urinary excretion on the 3rd day was ascribable to the suppression in the renal GAA formation system including GAT, arginine and so on.	Cephaloridine	125-138	alpha glucosidase	Rattus norvegicus	164-167
2752493-7	1989	These results suggest that the rise in the urinary excretion of GAA on the 1st day was ascribable to an inhibitory effect of cephaloridine on renal reabsorption of GAA, and that the fall in its urinary excretion on the 3rd day was ascribable to the suppression in the renal GAA formation system including GAT, arginine and so on.	Cephaloridine	125-138	alpha glucosidase	Rattus norvegicus	164-167
2724682-0	1989	Changes in lipid peroxidation and activities of xanthine oxidase, superoxide dismutase and catalase in kidneys of cephaloridine-administered rats.	Cephaloridine	114-127	catalase	Rattus norvegicus	91-99
2907014-1	1988	The incidence of cephaloridine resistance (minimum inhibitory concentration, MIC greater than 8 mg L-1) in isolates from urinary tract infections was 45.1% in Glasgow, 22.6% in Dundee and 25.9% in Edinburgh.	Cephaloridine	17-30	immunoglobulin kappa variable 1-16	Homo sapiens	99-102
3190346-1	1988	The effect of various doses of benzylpenicillin, streptomycin, cephaloridine (ceporin) and exogenic lysozyme on stability of lysozyme binding to lysosomal membranes of human blood monocytes was studied with the procedure developed by the authors which included estimation of the secreted and total lysozyme and evaluation of the stability index of the lysosomal membranes (SILM).	Cephaloridine	63-76	lysozyme	Homo sapiens	125-133
3190346-1	1988	The effect of various doses of benzylpenicillin, streptomycin, cephaloridine (ceporin) and exogenic lysozyme on stability of lysozyme binding to lysosomal membranes of human blood monocytes was studied with the procedure developed by the authors which included estimation of the secreted and total lysozyme and evaluation of the stability index of the lysosomal membranes (SILM).	Cephaloridine	63-76	lysozyme	Homo sapiens	125-133
3190346-1	1988	The effect of various doses of benzylpenicillin, streptomycin, cephaloridine (ceporin) and exogenic lysozyme on stability of lysozyme binding to lysosomal membranes of human blood monocytes was studied with the procedure developed by the authors which included estimation of the secreted and total lysozyme and evaluation of the stability index of the lysosomal membranes (SILM).	Cephaloridine	78-85	lysozyme	Homo sapiens	125-133
3190346-1	1988	The effect of various doses of benzylpenicillin, streptomycin, cephaloridine (ceporin) and exogenic lysozyme on stability of lysozyme binding to lysosomal membranes of human blood monocytes was studied with the procedure developed by the authors which included estimation of the secreted and total lysozyme and evaluation of the stability index of the lysosomal membranes (SILM).	Cephaloridine	78-85	lysozyme	Homo sapiens	125-133
3190346-6	1988	Cephaloridine had the labilizing effect by inhibition of the lysozyme intracellular synthesis.	Cephaloridine	0-13	lysozyme	Homo sapiens	61-69
3571286-6	1987	In addition, small amounts of lactotetraosylceramide, a blood group H-active triglycosylceramide with the structure of Fuc alpha 1-2Gal-Hex-Cer (where Fuc is fucose, Hex is hexose, and Cer is ceramide), and dihexosylceramides were identified in some cases.	Cephaloridine	140-143	hematopoietically expressed homeobox	Homo sapiens	136-139
3029897-9	1987	Direct addition of CPH to microsomal suspensions inhibited G6Pase activity in a concentration-dependent fashion.	Cephaloridine	19-22	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	59-65
3029897-11	1987	CPH increased the Km and decreased the Vmax of G6Pase, indicating mixed competitive and noncompetitive inhibition.	Cephaloridine	0-3	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	47-53
3029897-12	1987	These data indicate that the profound inhibition of renal cortical slice gluconeogenesis by CPH is mediated by inhibition of microsomal G6Pase activity.	Cephaloridine	92-95	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	136-142
3829983-0	1986	Vasopressin-resistant polyuria induced by cephaloridine administration in rats.	Cephaloridine	42-55	arginine vasopressin	Rattus norvegicus	0-11
4012797-12	1985	Cobalt chloride, known for its ability to decrease cellular concentration of cytochrome P-450, effectively decreased cephaloridine-induced lipid peroxidation.	Cephaloridine	117-130	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	77-93
2986707-4	1985	Cephaloridine-induced lipid peroxidation was inhibited by a combination of superoxide dismutase and catalase, by the hydroxyl radical scavengers, mannitol, (+)-cyanidanol-3 and by the singlet oxygen scavenger histidine in a concentration-dependent manner.	Cephaloridine	0-13	catalase	Rattus norvegicus	100-108
2986254-4	1985	Cephaloridine on the other hand inhibited PAH and NMN transport across rabbit basolateral membranes while it showed a lack of interaction with transport systems in rat basolateral membranes.	Cephaloridine	0-13	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	42-45
2986254-1	1985	The effects of cephaloridine and cephalothin on prototypical organic anion (p-aminohippurate, PAH) and cation (N-methylnicotinamide, NMN) transport were observed in brush border and basolateral membrane vesicles prepared from rat and rabbit renal cortex.	Cephaloridine	15-28	phenylalanine hydroxylase	Rattus norvegicus	94-97
1239674-41	1975	In cephaloridine cases, the tendency was observed, that which, as concentration of the drug in CSF increased, cell count and protein decreased, and, as concentration of the drug decreased, cell count and protein increased.	Cephaloridine	3-16	colony stimulating factor 2	Homo sapiens	95-98
6100830-3	1982	Thus, it was of interest to determine the effects of PBB, TSO and BNF on cephaloridine toxicity in Fischer 344 rats.	Cephaloridine	73-86	natriuretic peptide B	Rattus norvegicus	66-69
646349-2	1978	However, we have found that such a strain susceptible to 0.06 mug of penicillin per ml and 0.56 mug of methicillin per ml produces beta-lactamase(s) which hydrolyzes penicillin G, methicillin, 6-aminopenicillanic acid, and probably cephaloridine.	Cephaloridine	232-245	beta-lactamase	Staphylococcus aureus	131-145
339827-3	1977	A decrease in the fibrinogen level was found in the mastitis patients treated with semi-synthetic penicillins and cephaloridin.	Cephaloridine	114-126	fibrinogen beta chain	Homo sapiens	18-28
883788-3	1977	However, lower titers of alpha-antitoxin, lysine levels and C-reactive protein content were registered in the mastitis patients treated with cephaloridin.	Cephaloridine	141-153	C-reactive protein	Homo sapiens	60-78
857425-1	1977	A human antibody which preferentially agglutinates p erythrocytes is inhibited specifically by the glycolipid sialosylparagloboside, NeuNAc (alpha,2 leads to 3)Gal(beta,1 leads t0 4)GlcNAc(beta,1 leads to 3)Gal(beta,1 leads to 4)Glc-Cer and forms a precipitin band with this compound in agarose gel.	Cephaloridine	233-236	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	164-170
857425-1	1977	A human antibody which preferentially agglutinates p erythrocytes is inhibited specifically by the glycolipid sialosylparagloboside, NeuNAc (alpha,2 leads to 3)Gal(beta,1 leads t0 4)GlcNAc(beta,1 leads to 3)Gal(beta,1 leads to 4)Glc-Cer and forms a precipitin band with this compound in agarose gel.	Cephaloridine	233-236	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	189-195
857425-1	1977	A human antibody which preferentially agglutinates p erythrocytes is inhibited specifically by the glycolipid sialosylparagloboside, NeuNAc (alpha,2 leads to 3)Gal(beta,1 leads t0 4)GlcNAc(beta,1 leads to 3)Gal(beta,1 leads to 4)Glc-Cer and forms a precipitin band with this compound in agarose gel.	Cephaloridine	233-236	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	189-195
20165397-2	1976	Expansion coefficients in the -150-300 degrees C temperature range are shown for Owens-Illinois Cer-Vit C-101, Corning ULE 7971 (titanium silicate) and fused silica 7940, Heraeus-Schott Zerodur low-expansion material and Homosil fused silica, Universal Cyclops Invar LR-35, and Simonds Saw and Steel Super Invar.	Cephaloridine	96-99	vitrin	Homo sapiens	100-103
1239674-42	1975	CSF/serum concentration ratio of Cephaloridine increased, when time passed, in intramuscular, 3 minutes intravenous, and 1 hour-intravenous drip group.	Cephaloridine	33-46	colony stimulating factor 2	Homo sapiens	0-3
1239674-45	1975	In Cephaloridine group, mean value of CSF/serum ratio showed.	Cephaloridine	3-16	colony stimulating factor 2	Homo sapiens	38-41
234666-5	1975	Acute renal failure of comparable or greater severity to that induced by angiotensin II was produced by intramuscular cephaloridine, and was not associated with cardiac lesions.	Cephaloridine	118-131	angiotensinogen	Homo sapiens	73-87
163847-6	1975	With E. coli cephaloridine was a poorer inducer of beta-lactamase than were the antagonized antibiotic and 6-aminopenicillanic acid.	Cephaloridine	13-26	beta-lactamase	Escherichia coli	51-65
32575028-13	2020	We found that PRS induced apoptosis by interfering with bile acid-mediated sphingolipid metabolic pathway and Cer/SM balance in CLI.	Cephaloridine	110-113	PRS	Homo sapiens	14-17
32575028-18	2020	Both in vivo and in vitro, PRS induced Cer/SM imbalance which promoted lipid metabolism disorder and apoptosis.	Cephaloridine	39-42	PRS	Homo sapiens	27-30
30090852-8	2018	In the hippocampus, confocal microscopy revealed tPA-Cerulean (tPA-Cer) puncta localized to giant mossy fiber boutons (MFBs) and astrocytes in stratum lucidum.	Cephaloridine	53-56	plasminogen activator, tissue	Mus musculus	49-52
30090852-8	2018	In the hippocampus, confocal microscopy revealed tPA-Cerulean (tPA-Cer) puncta localized to giant mossy fiber boutons (MFBs) and astrocytes in stratum lucidum.	Cephaloridine	53-56	plasminogen activator, tissue	Mus musculus	63-66
27263077-2	2016	This study evaluated delivery of recombinant human apolipoprotein A-I (apoA-I) containing HDL mimetic CER-001 in carotid plaques in patients.	Cephaloridine	102-105	apolipoprotein A1	Homo sapiens	51-69
32789982-6	2021	Taking into account the relative abundance of complex [Cer + Li]+ at 572.8 m/z, it can be considered as a stable ion and therefore be used for the analysis of C18 -ceramide at low concentrations.	Cephaloridine	55-58	Bardet-Biedl syndrome 9	Homo sapiens	159-162
31991291-9	2020	In conclusion, Cer/Pom-PEG@GNPs can degrade intracellular ALK fusion proteins with minor off-target toxicity and can be applied in patients resistant to ALK inhibitors.	Cephaloridine	15-18	ALK receptor tyrosine kinase	Homo sapiens	58-61
31991291-9	2020	In conclusion, Cer/Pom-PEG@GNPs can degrade intracellular ALK fusion proteins with minor off-target toxicity and can be applied in patients resistant to ALK inhibitors.	Cephaloridine	15-18	ALK receptor tyrosine kinase	Homo sapiens	153-156
28714882-9	2017	After 6 months, vitamin D supplementation significantly enhanced plasma C18dihydroceramide (dhCer; N-stearoyl-sphinganine (d18:0/18:0)) and C18ceramide (Cer; N-stearoyl-sphingosine (d18:1/18:0)) levels were observed in the verum group compared to the placebo group.	Cephaloridine	94-97	Bardet-Biedl syndrome 9	Homo sapiens	72-75
27263077-2	2016	This study evaluated delivery of recombinant human apolipoprotein A-I (apoA-I) containing HDL mimetic CER-001 in carotid plaques in patients.	Cephaloridine	102-105	apolipoprotein A1	Homo sapiens	71-77
26708635-5	2016	Correlation studies showed that in GD the alpha-Syn dimer/monomer ratio is positively correlated with the levels of glucosylceramide (GlcCer) and the glucosylceramide/ceramide (GlcCer/Cer) ratio and negatively with the levels of malonyldialdehyde (MDA) and plasmalogens.	Cephaloridine	137-140	synuclein alpha	Homo sapiens	42-51