PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34921739-10	2022	Further study showed that compounds 3h, 3r, and 3s displayed superb antibacterial activity against E. carotorora with the EC50 values of 2.65, 4.24 and 4.29 mug/mL respectively, which were superior to streptomycin sulfate (EC50 = 5.96 mug/mL).	3r	40-42	thrombopoietin	Mus musculus	161-163
35563887-0	2022	Multifaceted and Intricate Oncogenic Mechanisms of NDRG1 in Head and Neck Cancer Depend on Its C-Terminal 3R-Motif.	3r	106-108	N-myc downstream regulated 1	Homo sapiens	51-56
12057909-8	2002	In contrast, soluble tau was composed of normal 4R/3R-tau ratios indicating no gross abnormality in tau splicing.	3r	51-53	microtubule associated protein tau	Homo sapiens	21-24
34679739-6	2021	Among them, compounds 3n, 3r, and 3u-w showed >70% inhibition of MAO-B and IC50 values of 1.41, 0.91, 1.20, 0.66, and 2.41 microM, respectively.	3r	26-28	monoamine oxidase B	Rattus norvegicus	65-70
34921739-10	2022	Further study showed that compounds 3h, 3r, and 3s displayed superb antibacterial activity against E. carotorora with the EC50 values of 2.65, 4.24 and 4.29 mug/mL respectively, which were superior to streptomycin sulfate (EC50 = 5.96 mug/mL).	3r	40-42	thrombopoietin	Mus musculus	239-241
34874917-4	2022	In this study, we observed strong colocalization of 4R tau within reactive astrocytes and increased expression of pan-reactive and neurotoxic genes following 3R to 4R tau splicing ASO treatment in hTau mice.	3r	158-160	microtubule associated protein tau	Homo sapiens	55-58
34874917-4	2022	In this study, we observed strong colocalization of 4R tau within reactive astrocytes and increased expression of pan-reactive and neurotoxic genes following 3R to 4R tau splicing ASO treatment in hTau mice.	3r	158-160	microtubule associated protein tau	Homo sapiens	167-170
34874917-4	2022	In this study, we observed strong colocalization of 4R tau within reactive astrocytes and increased expression of pan-reactive and neurotoxic genes following 3R to 4R tau splicing ASO treatment in hTau mice.	3r	158-160	microtubule associated protein tau	Homo sapiens	197-201
28019685-2	2018	Tau pathology is characterized as 3R (repeat) or 4R predominant or mixed 3R and 4R type.	3r	34-36	microtubule associated protein tau	Homo sapiens	0-3
28691164-6	2017	Double-labeling immunofluorescence demonstrated that 3R tau was hardly accumulated in 4R tau-positive inclusions.	3r	53-55	microtubule associated protein tau	Homo sapiens	56-59
28053030-10	2017	These findings suggest that changes in 3R:4R tau ratio has an impact on the regulation of axonal transport and specifically in APP dynamics, which might link tau isoform imbalances with APP abnormal metabolism in neurodegenerative processes.	3r	39-41	microtubule associated protein tau	Homo sapiens	45-48
33316691-4	2021	Subsequently, the enzymatic assay, molecular docking, and molecular dynamics (MD) simulations were carried out for validating that 3r could bind to Fam20C.	3r	131-133	FAM20C golgi associated secretory pathway kinase	Homo sapiens	148-154
33316691-7	2021	Taken together, these results suggest that 3r may be a novel Fam20C inhibitor with anti-proliferative and apoptosis-inducing activities, which would shed light on discovering more small-molecule drugs for the future TNBC therapy.	3r	43-45	FAM20C golgi associated secretory pathway kinase	Homo sapiens	61-67
28053030-10	2017	These findings suggest that changes in 3R:4R tau ratio has an impact on the regulation of axonal transport and specifically in APP dynamics, which might link tau isoform imbalances with APP abnormal metabolism in neurodegenerative processes.	3r	39-41	microtubule associated protein tau	Homo sapiens	158-161
24323931-9	2013	Pick bodies in PiD are immunopositive for 3R-tau.	3r	42-44	protein interacting with PRKCA 1	Homo sapiens	0-4
21807765-7	2011	miR-132 overexpression or PTBP2 knockdown similarly affected endogenous 4R:3R-tau ratios in neuronal cells.	3r	75-77	microRNA 132	Homo sapiens	0-7