PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35430075-8	2022	Taken together, these data suggest nootkatone toxicity in D. melanogaster is mediated through GABA receptor antagonism.	nootkatone	35-45	Resistant to dieldrin	Drosophila melanogaster	94-107
34492535-0	2021	Nootkatone protects cartilage against degeneration in mice by inhibiting NF-kappaB signaling pathway.	nootkatone	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-82
34492535-8	2021	The cellular mechanism of the protective effect of nootkatone in osteoarthritis and associated signaling pathway was identified as the NF-kappaB signaling pathway.	nootkatone	51-61	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
34480883-0	2021	Nootkatone confers antifibrotic effect by regulating the TGF-beta/Smad signaling pathway in mouse model of unilateral ureteral obstruction.	nootkatone	0-10	transforming growth factor alpha	Mus musculus	57-65
34480883-8	2021	Administration of NTK (10 mg/kg) prevented the activation of the TGF-beta/Smad signaling, expression of ECM components, markedly attenuated the renal tubular injury and fibrosis area (% area: 6.66 +- 1.45% vs UUO: 26.33 +- 2.90%).	nootkatone	18-21	transforming growth factor alpha	Mus musculus	65-73
34480883-9	2021	Administration of NTK at 10 mg/kg significantly restored the endogenous antioxidants and prevented the reactive oxygen species generation (25.31 +- 1.65% vs UUO: 45.01 +- 4.85%) and reduced the level of tumor necrosis factor (TNF)-alpha (95.22 +- 12.39 vs UUO: 215.57 +- 60.45 pg/mg protein) in the kidneys.	nootkatone	18-21	tumor necrosis factor	Mus musculus	203-236
33270352-5	2021	NKT (5 mg/kg) co-treatment remarkably ameliorates D-GalN-induced anxiety- and depression-like behaviors as evident from the results of sucrose preference test, forced swimming test, tail suspension test, and novelty suppressed feeding test.	nootkatone	0-3	galanin and GMAP prepropeptide	Mus musculus	52-56
35631492-8	2022	In silico docking analysis demonstrated that nootkatone efficiently bound to the active site of AMPK.	nootkatone	45-55	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	96-100
32392744-5	2020	In the acute inflammation models, NTK demonstrated antiedematogenic effects and inhibited leukocyte recruitment, which was associated with decreased vascular permeability, inhibition of myeloperoxidase (MPO), interleukin (IL)1-beta, and tumor necrosis factor (TNF)-alpha production.	nootkatone	34-37	myeloperoxidase	Mus musculus	186-201
33460769-0	2021	NQO1 mediates the anti-inflammatory effects of nootkatone in lipopolysaccharide-induced neuroinflammation by modulating the AMPK signaling pathway.	nootkatone	47-57	NAD(P)H dehydrogenase, quinone 1	Mus musculus	0-4
32709324-2	2020	In this demonstrative study, a design approach for high process throughput is applied for the trapping MDM separation of a target component, nootkatone (NK), initially comprising 16.7% of an industrial side stream mixture with over 90 impurities.	nootkatone	141-151	secreted LY6/PLAUR domain containing 1	Homo sapiens	103-106
32392744-5	2020	In the acute inflammation models, NTK demonstrated antiedematogenic effects and inhibited leukocyte recruitment, which was associated with decreased vascular permeability, inhibition of myeloperoxidase (MPO), interleukin (IL)1-beta, and tumor necrosis factor (TNF)-alpha production.	nootkatone	34-37	myeloperoxidase	Mus musculus	203-206
32392744-5	2020	In the acute inflammation models, NTK demonstrated antiedematogenic effects and inhibited leukocyte recruitment, which was associated with decreased vascular permeability, inhibition of myeloperoxidase (MPO), interleukin (IL)1-beta, and tumor necrosis factor (TNF)-alpha production.	nootkatone	34-37	interleukin 1 alpha	Mus musculus	209-231
32392744-5	2020	In the acute inflammation models, NTK demonstrated antiedematogenic effects and inhibited leukocyte recruitment, which was associated with decreased vascular permeability, inhibition of myeloperoxidase (MPO), interleukin (IL)1-beta, and tumor necrosis factor (TNF)-alpha production.	nootkatone	34-37	tumor necrosis factor	Mus musculus	237-270
32392744-8	2020	In conclusion, NTK exerted anti-inflammatory effects that are associated with inhibition of IL1-beta and TNF-alpha production, possibly due to inhibition of COX-2 activity and antagonism of the H1 receptor.	nootkatone	15-18	interleukin 1 alpha	Mus musculus	92-100
32392744-8	2020	In conclusion, NTK exerted anti-inflammatory effects that are associated with inhibition of IL1-beta and TNF-alpha production, possibly due to inhibition of COX-2 activity and antagonism of the H1 receptor.	nootkatone	15-18	tumor necrosis factor	Mus musculus	105-114
32392744-8	2020	In conclusion, NTK exerted anti-inflammatory effects that are associated with inhibition of IL1-beta and TNF-alpha production, possibly due to inhibition of COX-2 activity and antagonism of the H1 receptor.	nootkatone	15-18	cytochrome c oxidase II, mitochondrial	Mus musculus	157-162
29351455-11	2018	Likewise, heme oxygenase-1 was increased in mice treated with nootkatone + DEPs compared with those treated with DEPs or nootkatone + saline.	nootkatone	62-72	heme oxygenase 1	Mus musculus	10-26
32013959-10	2020	Our results showed that the short-chain dehydrogenase/reductase (SDR) superfamily dehydrogenases ZSD1 of Zingiber zerumbet and ABA2 of Citrus sinensis were capable of effectively catalyzing beta-nootkatol oxidation to (+)-nootkatone.	nootkatone	218-232	short chain alcohol dehydrogenase	Citrus sinensis	127-131
32013959-11	2020	The yield of (+)-nootkatone increased to 59.78 mg/L and 53.48 mg/L by additional overexpression of ZSD1 and ABA2, respectively.	nootkatone	13-27	short chain alcohol dehydrogenase	Citrus sinensis	108-112
32129354-0	2020	Synergistic neuroprotective effect of schisandrin and nootkatone on regulating inflammation, apoptosis and autophagy via the PI3K/AKT pathway.	nootkatone	54-64	AKT serine/threonine kinase 1	Rattus norvegicus	130-133
32277665-1	2020	PURPOSE: The main aim of the present study was to determine the antiproliferative effects induced by nootkatone-a plant sesquiterpene ketone along with determining its effects on autophagy, reactive oxygen species (ROS) production, cell cycle, cell migration and NF-kappaB signalling pathway.	nootkatone	101-111	nuclear factor kappa B subunit 1	Homo sapiens	263-272
32277665-8	2020	Nootkatone led to an increase of LC3B-II and LC3B-I but also led to inhibition of p62 expression.	nootkatone	0-10	microtubule associated protein 1 light chain 3 beta	Homo sapiens	33-37
32277665-8	2020	Nootkatone led to an increase of LC3B-II and LC3B-I but also led to inhibition of p62 expression.	nootkatone	0-10	nucleoporin 62	Homo sapiens	82-85
32277665-10	2020	Nootkatone also led to inhibition of cell migration along with inhibiting NF-kappaB signalling pathway.	nootkatone	0-10	nuclear factor kappa B subunit 1	Homo sapiens	74-83
32277665-11	2020	CONCLUSIONS: In conclusion, nootkatone molecule inhibits retinoblastoma by inhibiting Nf-kappaB signalling pathway and cell migration, autophagy induction, ROS generation and S-phase cell cycle arrest.	nootkatone	28-38	nuclear factor kappa B subunit 1	Homo sapiens	86-95
31341528-10	2019	Nootkatone also significantly mitigated the decrease in testosterone, androgen-binding protein, and estradiol concentrations in the plasma induced by WPS.	nootkatone	0-10	secretoglobin, family 1B, member 29	Mus musculus	70-94
29351455-9	2018	Nootkatone inhibited the increase of plasma concentration of fibrinogen, plasminogen activator inhibitor-1, interleukin-6, and lipid peroxidation induced by DEPs.	nootkatone	0-10	interleukin 6	Mus musculus	108-121
29351455-10	2018	Immunohistochemically, hearts showed an analogous increase in glutathione and nuclear factor erythroid-derived 2-like 2 expression by cardiac myocytes and endothelial cells after DEP exposure, and these effects were enhanced in mice treated with nootkatone + DEPs.	nootkatone	246-256	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-119
29351455-11	2018	Likewise, heme oxygenase-1 was increased in mice treated with nootkatone + DEPs compared with those treated with DEPs or nootkatone + saline.	nootkatone	121-131	heme oxygenase 1	Mus musculus	10-26
29351455-15	2018	Nootkatone-induced boosting of nuclear factor erythroid-derived 2-like 2 and heme oxygenase-1 levels in the heart of mice exposed to diesel exhaust particles suggests that its protective effect is, at least partly, mediated through nuclear factor erythroid-derived 2-like 2 and heme oxygenase-1 activation.	nootkatone	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	31-72
29351455-15	2018	Nootkatone-induced boosting of nuclear factor erythroid-derived 2-like 2 and heme oxygenase-1 levels in the heart of mice exposed to diesel exhaust particles suggests that its protective effect is, at least partly, mediated through nuclear factor erythroid-derived 2-like 2 and heme oxygenase-1 activation.	nootkatone	0-10	heme oxygenase 1	Mus musculus	77-93
29351455-15	2018	Nootkatone-induced boosting of nuclear factor erythroid-derived 2-like 2 and heme oxygenase-1 levels in the heart of mice exposed to diesel exhaust particles suggests that its protective effect is, at least partly, mediated through nuclear factor erythroid-derived 2-like 2 and heme oxygenase-1 activation.	nootkatone	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	232-273
29351455-15	2018	Nootkatone-induced boosting of nuclear factor erythroid-derived 2-like 2 and heme oxygenase-1 levels in the heart of mice exposed to diesel exhaust particles suggests that its protective effect is, at least partly, mediated through nuclear factor erythroid-derived 2-like 2 and heme oxygenase-1 activation.	nootkatone	0-10	heme oxygenase 1	Mus musculus	278-294
29495362-0	2018	In Vivo Protective Effects of Nootkatone against Particles-Induced Lung Injury Caused by Diesel Exhaust Is Mediated via the NF-kappaB Pathway.	nootkatone	30-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	124-133
29495362-13	2018	Similarly, nootkatone prevented DEP-induced DNA damage and prevented the proteolytic cleavage of caspase-3.	nootkatone	11-21	caspase 3	Mus musculus	97-106
29495362-14	2018	Moreover, nootkatone inhibited nuclear factor-kappaB (NF-kappaB) induced by DEP.	nootkatone	10-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	31-52
29495362-14	2018	Moreover, nootkatone inhibited nuclear factor-kappaB (NF-kappaB) induced by DEP.	nootkatone	10-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	54-63
29495362-15	2018	We conclude that nootkatone prevented the DEP-induced increase in airway resistance, lung inflammation, oxidative stress, and the subsequent DNA damage and apoptosis through a mechanism involving inhibition of NF-kappaB activation.	nootkatone	17-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	210-219
29214688-1	2018	In this study, the hepatoprotective and anti-fibrotic actions of nootkatone (NTK) were investigated using carbon tetrachloride (CCl4 )-induced liver fibrosis in mice.	nootkatone	65-75	chemokine (C-C motif) ligand 4	Mus musculus	128-132
29214688-1	2018	In this study, the hepatoprotective and anti-fibrotic actions of nootkatone (NTK) were investigated using carbon tetrachloride (CCl4 )-induced liver fibrosis in mice.	nootkatone	77-80	chemokine (C-C motif) ligand 4	Mus musculus	128-132
26614990-6	2015	The IC50 (concentration that inhibits enzyme activity by 50%) values of plumbagin and nootkatone (selective inhibitor) for CYP2C19 were (0.78 +- 0.01) and (27.31 +- 0.66) muM, respectively.	nootkatone	86-96	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	123-130
26614990-6	2015	The IC50 (concentration that inhibits enzyme activity by 50%) values of plumbagin and nootkatone (selective inhibitor) for CYP2C19 were (0.78 +- 0.01) and (27.31 +- 0.66) muM, respectively.	nootkatone	86-96	latexin	Homo sapiens	171-174
24704449-0	2014	(+)-Nootkatone inhibits tumor necrosis factor alpha/interferon gamma-induced production of chemokines in HaCaT cells.	nootkatone	0-14	tumor necrosis factor	Homo sapiens	24-51
24704449-0	2014	(+)-Nootkatone inhibits tumor necrosis factor alpha/interferon gamma-induced production of chemokines in HaCaT cells.	nootkatone	0-14	interferon gamma	Homo sapiens	52-68
24704449-4	2014	The purpose of this study was to investigate the effect of (+)-nootkatone on tumor necrosis factor alpha (TNF-alpha)/interferon gamma (IFN-gamma)-induced expression of Th2 chemokines in HaCaT cells.	nootkatone	59-73	tumor necrosis factor	Homo sapiens	77-104
24704449-4	2014	The purpose of this study was to investigate the effect of (+)-nootkatone on tumor necrosis factor alpha (TNF-alpha)/interferon gamma (IFN-gamma)-induced expression of Th2 chemokines in HaCaT cells.	nootkatone	59-73	tumor necrosis factor	Homo sapiens	106-115
24704449-4	2014	The purpose of this study was to investigate the effect of (+)-nootkatone on tumor necrosis factor alpha (TNF-alpha)/interferon gamma (IFN-gamma)-induced expression of Th2 chemokines in HaCaT cells.	nootkatone	59-73	interferon gamma	Homo sapiens	117-144
24704449-5	2014	We found that (+)-nootkatone inhibited the TNF-alpha/IFN-gamma-induced expression of TARC/CCL17 and MDC/CCL22 mRNA in HaCaT cells.	nootkatone	14-28	tumor necrosis factor	Homo sapiens	43-52
24704449-5	2014	We found that (+)-nootkatone inhibited the TNF-alpha/IFN-gamma-induced expression of TARC/CCL17 and MDC/CCL22 mRNA in HaCaT cells.	nootkatone	14-28	interferon gamma	Homo sapiens	53-62
24704449-5	2014	We found that (+)-nootkatone inhibited the TNF-alpha/IFN-gamma-induced expression of TARC/CCL17 and MDC/CCL22 mRNA in HaCaT cells.	nootkatone	14-28	C-C motif chemokine ligand 17	Homo sapiens	85-89
24704449-5	2014	We found that (+)-nootkatone inhibited the TNF-alpha/IFN-gamma-induced expression of TARC/CCL17 and MDC/CCL22 mRNA in HaCaT cells.	nootkatone	14-28	C-C motif chemokine ligand 17	Homo sapiens	90-95
24704449-5	2014	We found that (+)-nootkatone inhibited the TNF-alpha/IFN-gamma-induced expression of TARC/CCL17 and MDC/CCL22 mRNA in HaCaT cells.	nootkatone	14-28	C-C motif chemokine ligand 22	Homo sapiens	100-103
24704449-5	2014	We found that (+)-nootkatone inhibited the TNF-alpha/IFN-gamma-induced expression of TARC/CCL17 and MDC/CCL22 mRNA in HaCaT cells.	nootkatone	14-28	C-C motif chemokine ligand 22	Homo sapiens	104-109
24704449-8	2014	Taken together, these results suggest that (+)-nootkatone may suppress TNF-alpha/IFN-gamma-induced TARC/CCL17 and MDC/CCL22 expression in HaCaT cells by inhibiting of PKCzeta and p38 MAPK signaling pathways that lead to activation of NF-kappaB.	nootkatone	43-57	tumor necrosis factor	Homo sapiens	71-80
24704449-8	2014	Taken together, these results suggest that (+)-nootkatone may suppress TNF-alpha/IFN-gamma-induced TARC/CCL17 and MDC/CCL22 expression in HaCaT cells by inhibiting of PKCzeta and p38 MAPK signaling pathways that lead to activation of NF-kappaB.	nootkatone	43-57	interferon gamma	Homo sapiens	81-90
24704449-8	2014	Taken together, these results suggest that (+)-nootkatone may suppress TNF-alpha/IFN-gamma-induced TARC/CCL17 and MDC/CCL22 expression in HaCaT cells by inhibiting of PKCzeta and p38 MAPK signaling pathways that lead to activation of NF-kappaB.	nootkatone	43-57	C-C motif chemokine ligand 17	Homo sapiens	99-103
24704449-8	2014	Taken together, these results suggest that (+)-nootkatone may suppress TNF-alpha/IFN-gamma-induced TARC/CCL17 and MDC/CCL22 expression in HaCaT cells by inhibiting of PKCzeta and p38 MAPK signaling pathways that lead to activation of NF-kappaB.	nootkatone	43-57	C-C motif chemokine ligand 17	Homo sapiens	104-109
24704449-8	2014	Taken together, these results suggest that (+)-nootkatone may suppress TNF-alpha/IFN-gamma-induced TARC/CCL17 and MDC/CCL22 expression in HaCaT cells by inhibiting of PKCzeta and p38 MAPK signaling pathways that lead to activation of NF-kappaB.	nootkatone	43-57	C-C motif chemokine ligand 22	Homo sapiens	114-117
24704449-8	2014	Taken together, these results suggest that (+)-nootkatone may suppress TNF-alpha/IFN-gamma-induced TARC/CCL17 and MDC/CCL22 expression in HaCaT cells by inhibiting of PKCzeta and p38 MAPK signaling pathways that lead to activation of NF-kappaB.	nootkatone	43-57	C-C motif chemokine ligand 22	Homo sapiens	118-123
24704449-8	2014	Taken together, these results suggest that (+)-nootkatone may suppress TNF-alpha/IFN-gamma-induced TARC/CCL17 and MDC/CCL22 expression in HaCaT cells by inhibiting of PKCzeta and p38 MAPK signaling pathways that lead to activation of NF-kappaB.	nootkatone	43-57	protein kinase C zeta	Homo sapiens	167-174
24704449-8	2014	Taken together, these results suggest that (+)-nootkatone may suppress TNF-alpha/IFN-gamma-induced TARC/CCL17 and MDC/CCL22 expression in HaCaT cells by inhibiting of PKCzeta and p38 MAPK signaling pathways that lead to activation of NF-kappaB.	nootkatone	43-57	mitogen-activated protein kinase 14	Homo sapiens	179-182
24704449-8	2014	Taken together, these results suggest that (+)-nootkatone may suppress TNF-alpha/IFN-gamma-induced TARC/CCL17 and MDC/CCL22 expression in HaCaT cells by inhibiting of PKCzeta and p38 MAPK signaling pathways that lead to activation of NF-kappaB.	nootkatone	43-57	nuclear factor kappa B subunit 1	Homo sapiens	234-243
25149566-5	2014	Of 17 reported mOR-EG ligands tested, including eugenol, its analogs, and structurally dissimilar compounds (mousse cristal, nootkatone, orivone), some equally activated both signaling pathways, some differentially activated both signaling pathways, and some had no noticeable effect even at 1-5mM.	nootkatone	125-135	olfactory receptor family 5 subfamily D member 18	Mus musculus	15-21
21843620-0	2011	(+)-Nootkatone and (+)-valencene from rhizomes of Cyperus rotundus increase survival rates in septic mice due to heme oxygenase-1 induction.	nootkatone	0-14	heme oxygenase 1	Mus musculus	113-129
21843620-8	2011	Nootkatone and valencene (sesquiterpenes) significantly inhibited iNOS expression and NO production in LPS-simulated RAW264.7 cells.	nootkatone	0-10	nitric oxide synthase 2, inducible	Mus musculus	66-70
21843620-9	2011	Inhibition of iNOS expression by nootkatone, valencene, and ECR were significantly reduced in siHO-1 RNA transfected cells.	nootkatone	33-43	nitric oxide synthase 2, inducible	Mus musculus	14-18
21843620-11	2011	CONCLUSIONS: Taken together, we concluded that possible anti-inflammatory mechanism of ECR is, at least, due to HO-1 induction, in which sesquiterpenes such as nootkatone and valencene play a crucial role.	nootkatone	160-170	heme oxygenase 1	Mus musculus	112-116
20501876-0	2010	Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK.	nootkatone	0-10	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	133-137
20501876-2	2010	Here, we identified and characterized nootkatone, a constituent of grapefruit, as a naturally occurring AMPK activator.	nootkatone	38-48	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	104-108
20501876-3	2010	Nootkatone induced an increase in AMPKalpha1 and -alpha2 activity along with an increase in the AMP/ATP ratio and an increase the phosphorylation of AMPKalpha and the downstream target acetyl-CoA carboxylase (ACC), in C(2)C(12) cells.	nootkatone	0-10	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	34-56
20501876-4	2010	Nootkatone-induced activation of AMPK was possibly mediated both by LKB1 and Ca(2+)/calmodulin-dependent protein kinase kinase.	nootkatone	0-10	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	33-37
20501876-4	2010	Nootkatone-induced activation of AMPK was possibly mediated both by LKB1 and Ca(2+)/calmodulin-dependent protein kinase kinase.	nootkatone	0-10	serine/threonine kinase 11	Mus musculus	68-72
20501876-5	2010	Nootkatone also upregulated PPARgamma coactivator-1alpha in C(2)C(12) cells and C57BL/6J mouse muscle.	nootkatone	0-10	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	28-56
20501876-6	2010	In addition, administration of nootkatone (200 mg/kg body wt) significantly enhanced AMPK activity, accompanied by LKB1, AMPK, and ACC phosphorylation in the liver and muscle of mice.	nootkatone	31-41	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	85-89
20501876-6	2010	In addition, administration of nootkatone (200 mg/kg body wt) significantly enhanced AMPK activity, accompanied by LKB1, AMPK, and ACC phosphorylation in the liver and muscle of mice.	nootkatone	31-41	serine/threonine kinase 11	Mus musculus	115-119
20501876-6	2010	In addition, administration of nootkatone (200 mg/kg body wt) significantly enhanced AMPK activity, accompanied by LKB1, AMPK, and ACC phosphorylation in the liver and muscle of mice.	nootkatone	31-41	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	121-125
20501876-10	2010	These findings indicate that long-term intake of nootkatone is beneficial toward preventing obesity and improving physical performance and that these effects are due, at least in part, to enhanced energy metabolism through AMPK activation in skeletal muscle and liver.	nootkatone	49-59	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	223-227